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Title: Understanding mutagenesis through delineation of mutational signatures in human cancer

Each individual cell within a human body acquires a certain number of somatic mutations during a course of its lifetime. These mutations originate from a wide spectra of both endogenous and exogenous mutational processes that leave distinct patterns of mutations, termed mutational signatures, embedded within the genomes of all cells. In recent years, the vast amount of data produced by sequencing of cancer genomes was coupled with novel mathematical models and computational tools to generate the first comprehensive map of mutational signatures in human cancer. Up to date, >30 distinct mutational signatures have been identified, and etiologies have been proposed for many of them. This paper provides a brief historical background on examination of mutational patterns in human cancer, summarizes the knowledge accumulated since introducing the concept of mutational signatures and discusses their future potential applications and perspectives within the field.
Authors:
 [1] ;  [2]
  1. Wellcome Trust Sanger Institute, Cambridge (United Kingdom)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of New Mexico Cancer Center, Albuquerque, NM (United States)
Publication Date:
OSTI Identifier:
1256297
Report Number(s):
LA-UR--16-22533
Journal ID: ISSN 0143-3334
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Carcinogenesis
Additional Journal Information:
Journal Volume: 37; Journal Issue: 6; Journal ID: ISSN 0143-3334
Publisher:
Oxford University Press
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES Biological Science