Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
- Authors:
- more »
- Publication Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Inst. of Allergy and Infectious Diseases (NIAID); National Inst. of Health
- OSTI Identifier:
- 1255622
- Alternate Identifier(s):
- OSTI ID: 1243357; OSTI ID: 1245875
- Grant/Contract Number:
- W-31-109-Eng-38; AI037526; AI072529; AI0678501; P01 AI094419; P01 AI100148; P01 AI104722; 1UM1 AI100663; UM1 AI100645
- Resource Type:
- Published Article
- Journal Name:
- Cell
- Additional Journal Information:
- Journal Name: Cell Journal Volume: 161 Journal Issue: 6; Journal ID: ISSN 0092-8674
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Zhou, Tongqing, Lynch, Rebecca M., Chen, Lei, Acharya, Priyamvada, Wu, Xueling, Doria-Rose, Nicole A., Joyce, M. Gordon, Lingwood, Daniel, Soto, Cinque, Bailer, Robert T., Ernandes, Michael J., Kong, Rui, Longo, Nancy S., Louder, Mark K., McKee, Krisha, O’Dell, Sijy, Schmidt, Stephen D., Tran, Lillian, Yang, Zhongjia, Druz, Aliaksandr, Luongo, Timothy S., Moquin, Stephanie, Srivatsan, Sanjay, Yang, Yongping, Zhang, Baoshan, Zheng, Anqi, Pancera, Marie, Kirys, Tatsiana, Georgiev, Ivelin S., Gindin, Tatyana, Peng, Hung-Pin, Yang, An-Suei, Mullikin, James C., Gray, Matthew D., Stamatatos, Leonidas, Burton, Dennis R., Koff, Wayne C., Cohen, Myron S., Haynes, Barton F., Casazza, Joseph P., Connors, Mark, Corti, Davide, Lanzavecchia, Antonio, Sattentau, Quentin J., Weiss, Robin A., West, Jr., Anthony P., Bjorkman, Pamela J., Scheid, Johannes F., Nussenzweig, Michel C., Shapiro, Lawrence, Mascola, John R., and Kwong, Peter D. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. United States: N. p., 2015.
Web. doi:10.1016/j.cell.2015.05.007.
Zhou, Tongqing, Lynch, Rebecca M., Chen, Lei, Acharya, Priyamvada, Wu, Xueling, Doria-Rose, Nicole A., Joyce, M. Gordon, Lingwood, Daniel, Soto, Cinque, Bailer, Robert T., Ernandes, Michael J., Kong, Rui, Longo, Nancy S., Louder, Mark K., McKee, Krisha, O’Dell, Sijy, Schmidt, Stephen D., Tran, Lillian, Yang, Zhongjia, Druz, Aliaksandr, Luongo, Timothy S., Moquin, Stephanie, Srivatsan, Sanjay, Yang, Yongping, Zhang, Baoshan, Zheng, Anqi, Pancera, Marie, Kirys, Tatsiana, Georgiev, Ivelin S., Gindin, Tatyana, Peng, Hung-Pin, Yang, An-Suei, Mullikin, James C., Gray, Matthew D., Stamatatos, Leonidas, Burton, Dennis R., Koff, Wayne C., Cohen, Myron S., Haynes, Barton F., Casazza, Joseph P., Connors, Mark, Corti, Davide, Lanzavecchia, Antonio, Sattentau, Quentin J., Weiss, Robin A., West, Jr., Anthony P., Bjorkman, Pamela J., Scheid, Johannes F., Nussenzweig, Michel C., Shapiro, Lawrence, Mascola, John R., & Kwong, Peter D. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. United States. https://doi.org/10.1016/j.cell.2015.05.007
Zhou, Tongqing, Lynch, Rebecca M., Chen, Lei, Acharya, Priyamvada, Wu, Xueling, Doria-Rose, Nicole A., Joyce, M. Gordon, Lingwood, Daniel, Soto, Cinque, Bailer, Robert T., Ernandes, Michael J., Kong, Rui, Longo, Nancy S., Louder, Mark K., McKee, Krisha, O’Dell, Sijy, Schmidt, Stephen D., Tran, Lillian, Yang, Zhongjia, Druz, Aliaksandr, Luongo, Timothy S., Moquin, Stephanie, Srivatsan, Sanjay, Yang, Yongping, Zhang, Baoshan, Zheng, Anqi, Pancera, Marie, Kirys, Tatsiana, Georgiev, Ivelin S., Gindin, Tatyana, Peng, Hung-Pin, Yang, An-Suei, Mullikin, James C., Gray, Matthew D., Stamatatos, Leonidas, Burton, Dennis R., Koff, Wayne C., Cohen, Myron S., Haynes, Barton F., Casazza, Joseph P., Connors, Mark, Corti, Davide, Lanzavecchia, Antonio, Sattentau, Quentin J., Weiss, Robin A., West, Jr., Anthony P., Bjorkman, Pamela J., Scheid, Johannes F., Nussenzweig, Michel C., Shapiro, Lawrence, Mascola, John R., and Kwong, Peter D. Mon .
"Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors". United States. https://doi.org/10.1016/j.cell.2015.05.007.
@article{osti_1255622,
title = {Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors},
author = {Zhou, Tongqing and Lynch, Rebecca M. and Chen, Lei and Acharya, Priyamvada and Wu, Xueling and Doria-Rose, Nicole A. and Joyce, M. Gordon and Lingwood, Daniel and Soto, Cinque and Bailer, Robert T. and Ernandes, Michael J. and Kong, Rui and Longo, Nancy S. and Louder, Mark K. and McKee, Krisha and O’Dell, Sijy and Schmidt, Stephen D. and Tran, Lillian and Yang, Zhongjia and Druz, Aliaksandr and Luongo, Timothy S. and Moquin, Stephanie and Srivatsan, Sanjay and Yang, Yongping and Zhang, Baoshan and Zheng, Anqi and Pancera, Marie and Kirys, Tatsiana and Georgiev, Ivelin S. and Gindin, Tatyana and Peng, Hung-Pin and Yang, An-Suei and Mullikin, James C. and Gray, Matthew D. and Stamatatos, Leonidas and Burton, Dennis R. and Koff, Wayne C. and Cohen, Myron S. and Haynes, Barton F. and Casazza, Joseph P. and Connors, Mark and Corti, Davide and Lanzavecchia, Antonio and Sattentau, Quentin J. and Weiss, Robin A. and West, Jr., Anthony P. and Bjorkman, Pamela J. and Scheid, Johannes F. and Nussenzweig, Michel C. and Shapiro, Lawrence and Mascola, John R. and Kwong, Peter D.},
abstractNote = {},
doi = {10.1016/j.cell.2015.05.007},
journal = {Cell},
number = 6,
volume = 161,
place = {United States},
year = {Mon Jun 01 00:00:00 EDT 2015},
month = {Mon Jun 01 00:00:00 EDT 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1016/j.cell.2015.05.007
https://doi.org/10.1016/j.cell.2015.05.007
Other availability
Cited by: 231 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
journal, October 2014
- Pancera, Marie; Zhou, Tongqing; Druz, Aliaksandr
- Nature, Vol. 514, Issue 7523
Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope
journal, September 2004
- Ofek, G.; Tang, M.; Sambor, A.
- Journal of Virology, Vol. 78, Issue 19
Free energy determinants of tertiary structure and the evaluation of protein models
journal, January 2000
- Petrey, Donald; Honig, Barry
- Protein Science, Vol. 9, Issue 11
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
journal, September 2012
- Huang, Jinghe; Ofek, Gilad; Laub, Leo
- Nature, Vol. 491, Issue 7424
Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design
journal, October 2011
- Diskin, R.; Scheid, J. F.; Marcovecchio, P. M.
- Science, Vol. 334, Issue 6060
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
journal, January 2008
- Tiller, Thomas; Meffre, Eric; Yurasov, Sergey
- Journal of Immunological Methods, Vol. 329, Issue 1-2
Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies
journal, May 2013
- Diskin, Ron; Klein, Florian; Horwitz, Joshua A.
- The Journal of Experimental Medicine, Vol. 210, Issue 6
Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization
journal, May 2013
- Georgiev, I. S.; Doria-Rose, N. A.; Zhou, T.
- Science, Vol. 340, Issue 6133
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
journal, July 2011
- Scheid, J. F.; Mouquet, H.; Ueberheide, B.
- Science, Vol. 333, Issue 6049
A New Clustering of Antibody CDR Loop Conformations
journal, February 2011
- North, Benjamin; Lehmann, Andreas; Dunbrack, Roland L.
- Journal of Molecular Biology, Vol. 406, Issue 2
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
journal, June 1998
- Kwong, Peter D.; Wyatt, Richard; Robinson, James
- Nature, Vol. 393, Issue 6686
Crystal structure of an HIV-binding recombinant fragment of human CD4
journal, November 1990
- Ryu, Seong-Eon; Kwong, Peter D.; Truneh, Alemseged
- Nature, Vol. 348, Issue 6300
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
journal, November 1994
- Burton, D.; Pyati, J.; Koduri, R.
- Science, Vol. 266, Issue 5187
Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
journal, October 2013
- Julien, J. -P.; Cupo, A.; Sok, D.
- Science, Vol. 342, Issue 6165
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
journal, March 2013
- Jardine, J.; Julien, J. -P.; Menis, S.
- Science, Vol. 340, Issue 6133
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains
journal, November 1990
- Wang, Jiahuai; Yan, Youwei; Garrett, Thomas P. J.
- Nature, Vol. 348, Issue 6300
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
journal, October 2013
- Lyumkis, D.; Julien, J. -P.; de Val, N.
- Science, Vol. 342, Issue 6165
Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme
journal, September 1996
- Desmyter, Aline; Transue, Thomas R.; Ghahroudi, Mehdi Arbabi
- Nature Structural & Molecular Biology, Vol. 3, Issue 9
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
journal, July 2010
- Wu, X.; Yang, Z. -Y.; Li, Y.
- Science, Vol. 329, Issue 5993
Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.
journal, August 1989
- Padlan, E. A.; Silverton, E. W.; Sheriff, S.
- Proceedings of the National Academy of Sciences, Vol. 86, Issue 15
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection
journal, April 2015
- Wu, Xueling; Zhang, Zhenhai; Schramm, Chaim A.
- Cell, Vol. 161, Issue 3
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
journal, April 2013
- Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing
- Nature, Vol. 496, Issue 7446
HIV infection of primate lymphocytes and conservation of the CD4 receptor
journal, December 1987
- McClure, Myra O.; Sattentau, Quentin J.; Beverley, Peter C. L.
- Nature, Vol. 330, Issue 6147
The Development of CD4 Binding Site Antibodies during HIV-1 Infection
journal, May 2012
- Lynch, R. M.; Tran, L.; Louder, M. K.
- Journal of Virology, Vol. 86, Issue 14
Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C
journal, September 2008
- Binley, J. M.; Lybarger, E. A.; Crooks, E. T.
- Journal of Virology, Vol. 82, Issue 23
Somatic populations of PGT135–137 HIV-1-neutralizing antibodies identified by 454 pyrosequencing and bioinformatic
journal, January 2012
- Zhu, Jiang
- Frontiers in Microbiology, Vol. 3
A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals
journal, August 2010
- Walker, Laura M.; Simek, Melissa D.; Priddy, Frances
- PLoS Pathogens, Vol. 6, Issue 8
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
journal, July 2010
- Zhou, T.; Georgiev, I.; Wu, X.
- Science, Vol. 329, Issue 5993
Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo
journal, August 2014
- Rudicell, R. S.; Kwon, Y. D.; Ko, S. -Y.
- Journal of Virology, Vol. 88, Issue 21
Frequency and Phenotype of Human Immunodeficiency Virus Envelope-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies
journal, October 2008
- Doria-Rose, N. A.; Klein, R. M.; Manion, M. M.
- Journal of Virology, Vol. 83, Issue 1
Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1
journal, November 1994
- Braden, Bradford C.; Souchon, Hélène; Eiselé, Jean-Luc
- Journal of Molecular Biology, Vol. 243, Issue 4
Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition
journal, June 2003
- Calarese, D. A.
- Science, Vol. 300, Issue 5628
Coot model-building tools for molecular graphics
journal, November 2004
- Emsley, Paul; Cowtan, Kevin
- Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41
journal, February 2005
- Cardoso, Rosa M. F.; Zwick, Michael B.; Stanfield, Robyn L.
- Immunity, Vol. 22, Issue 2
Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
journal, January 2010
- Corti, Davide; Langedijk, Johannes P. M.; Hinz, Andreas
- PLoS ONE, Vol. 5, Issue 1
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
journal, March 2013
- McGuire, Andrew T.; Hoot, Sam; Dreyer, Anita M.
- The Journal of Experimental Medicine, Vol. 210, Issue 4
A method for identification of HIV gp140 binding memory B cells in human blood
journal, April 2009
- Scheid, Johannes F.; Mouquet, Hugo; Feldhahn, Niklas
- Journal of Immunological Methods, Vol. 343, Issue 2
Broad HIV-1 neutralization mediated by CD4-binding site antibodies
journal, August 2007
- Li, Yuxing; Migueles, Stephen A.; Welcher, Brent
- Nature Medicine, Vol. 13, Issue 9
PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010
- Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops
journal, March 2012
- Kwon, Y. D.; Finzi, A.; Wu, X.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 15
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
journal, February 2014
- West, Anthony P.; Scharf, Louise; Scheid, Johannes F.
- Cell, Vol. 156, Issue 4
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
journal, October 2011
- Pejchal, R.; Doores, K. J.; Walker, L. M.
- Science, Vol. 334, Issue 6059
Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
journal, March 2013
- Klein, Florian; Diskin, Ron; Scheid, Johannes F.
- Cell, Vol. 153, Issue 1
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
journal, May 2013
- Kong, Leopold; Lee, Jeong Hyun; Doores, Katie J.
- Nature Structural & Molecular Biology, Vol. 20, Issue 7
Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies
journal, September 2012
- Kwong, Peter D.; Mascola, John R.
- Immunity, Vol. 37, Issue 3
Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120
journal, June 2012
- West, Anthony P.; Diskin, Ron; Nussenzweig, Michel C.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 30
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection
journal, January 2014
- Hraber, Peter; Seaman, Michael S.; Bailer, Robert T.
- AIDS, Vol. 28, Issue 2
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
journal, August 2011
- Wu, X.; Zhou, T.; Zhu, J.
- Science, Vol. 333, Issue 6049
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
journal, September 2010
- Mouquet, Hugo; Scheid, Johannes F.; Zoller, Markus J.
- Nature, Vol. 467, Issue 7315
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
journal, August 2013
- Zhou, Tongqing; Zhu, Jiang; Wu, Xueling
- Immunity, Vol. 39, Issue 2
De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts
journal, October 2013
- Zhu, J.; Wu, X.; Zhang, B.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 43
Structural definition of a conserved neutralization epitope on HIV-1 gp120
journal, February 2007
- Zhou, Tongqing; Xu, Ling; Dey, Barna
- Nature, Vol. 445, Issue 7129
Phaser crystallographic software
journal, July 2007
- McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
- Journal of Applied Crystallography, Vol. 40, Issue 4
Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120
journal, November 2009
- Chen, L.; Do Kwon, Y.; Zhou, T.
- Science, Vol. 326, Issue 5956