Small-angle neutron scattering reveals the assembly of alpha-synuclein in lipid membranes
- Authors:
- Publication Date:
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER); USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1251905
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Biochimica et Biophysica Acta. Proteins and Proteomics
- Additional Journal Information:
- Journal Name: Biochimica et Biophysica Acta. Proteins and Proteomics Journal Volume: 1854 Journal Issue: 12; Journal ID: ISSN 1570-9639
- Publisher:
- Elsevier
- Country of Publication:
- France
- Language:
- English
Citation Formats
Anunciado, Divina, Rai, Durgesh K., Qian, Shuo, Urban, Volker, and O'Neill, Hugh. Small-angle neutron scattering reveals the assembly of alpha-synuclein in lipid membranes. France: N. p., 2015.
Web. doi:10.1016/j.bbapap.2015.08.009.
Anunciado, Divina, Rai, Durgesh K., Qian, Shuo, Urban, Volker, & O'Neill, Hugh. Small-angle neutron scattering reveals the assembly of alpha-synuclein in lipid membranes. France. https://doi.org/10.1016/j.bbapap.2015.08.009
Anunciado, Divina, Rai, Durgesh K., Qian, Shuo, Urban, Volker, and O'Neill, Hugh. Tue .
"Small-angle neutron scattering reveals the assembly of alpha-synuclein in lipid membranes". France. https://doi.org/10.1016/j.bbapap.2015.08.009.
@article{osti_1251905,
title = {Small-angle neutron scattering reveals the assembly of alpha-synuclein in lipid membranes},
author = {Anunciado, Divina and Rai, Durgesh K. and Qian, Shuo and Urban, Volker and O'Neill, Hugh},
abstractNote = {},
doi = {10.1016/j.bbapap.2015.08.009},
journal = {Biochimica et Biophysica Acta. Proteins and Proteomics},
number = 12,
volume = 1854,
place = {France},
year = {Tue Dec 01 00:00:00 EST 2015},
month = {Tue Dec 01 00:00:00 EST 2015}
}
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https://doi.org/10.1016/j.bbapap.2015.08.009
https://doi.org/10.1016/j.bbapap.2015.08.009
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Cited by: 18 works
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Works referenced in this record:
Folding and misfolding of alpha-synuclein on membranes
journal, April 2012
- Dikiy, Igor; Eliezer, David
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1818, Issue 4
Single Molecule Characterization of α-Synuclein in Aggregation-Prone States
journal, November 2010
- Trexler, Adam J.; Rhoades, Elizabeth
- Biophysical Journal, Vol. 99, Issue 9
α‐Synuclein and Parkinson's disease
journal, February 2004
- Recchia, Alessandra; Debetto, Patrizia; Negro, Alessandro
- The FASEB Journal, Vol. 18, Issue 6
Sol–gel entrapped light harvesting antennas: immobilization and stabilization of chlorosomes for energy harvesting
journal, January 2012
- O'Dell, William B.; Beatty, Kayla J.; Kuo-Hsiang Tang, Joseph
- Journal of Materials Chemistry, Vol. 22, Issue 42
Lipids of synaptic vesicles: relevance to the mechanism of membrane fusion
journal, January 1981
- Deutsch, James W.; Kelly, Regis B.
- Biochemistry, Vol. 20, Issue 2
Identification of two distinct synucleins from human brain
journal, May 1994
- Jakes, Ross; Spillantini, Maria Grazia; Goedert, Michel
- FEBS Letters, Vol. 345, Issue 1
Adult rat brain synaptic vesicles II. Lipid composition
journal, October 1973
- Breckenridge, W. C.; Morgan, I. G.; Zanetta, J. P.
- Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 320, Issue 3
Temperature-Dependent Structural Changes of Parkinson's Alpha-Synuclein Reveal the Role of Pre-Existing Oligomers in Alpha-Synuclein Fibrillization
journal, January 2013
- Ariesandi, Winny; Chang, Chi-Fon; Chen, Tseng-Erh
- PLoS ONE, Vol. 8, Issue 1
α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles
journal, June 2013
- Varkey, Jobin; Mizuno, Naoko; Hegde, Balachandra G.
- Journal of Biological Chemistry, Vol. 288, Issue 24
Amyloids of Alpha-Synuclein Affect the Structure and Dynamics of Supported Lipid Bilayers
journal, June 2014
- Iyer, Aditya; Petersen, Nils O.; Claessens, Mireille M. A. E.
- Biophysical Journal, Vol. 106, Issue 12
Small angle neutron scattering study of deuterated sodium dodecylsulfate micellization in dilute poly((2–dimethylamino)ethyl methacrylate) solutions
journal, June 2010
- Lee, Wonjoo; Kofinas, Peter; Briber, R. M.
- Polymer, Vol. 51, Issue 13
The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by β-amyloid: is NAC a common trigger or target in neurodegenerative disease?
journal, March 1995
- Han, Hogyu; Weinreb, Paul H.; Lansbury, Peter T.
- Chemistry & Biology, Vol. 2, Issue 3
Molecular-weight Determination by Light Scattering.
journal, January 1947
- Debye, P.
- The Journal of Physical and Colloid Chemistry, Vol. 51, Issue 1
α-Synuclein Is Expressed in Different Tissues During Human Fetal Development
journal, January 2004
- Baltic, Svetlana; Perovic, Milka; Mladenovic, Aleksandra
- Journal of Molecular Neuroscience, Vol. 22, Issue 3
Interplay of -synuclein binding and conformational switching probed by single-molecule fluorescence
journal, March 2009
- Ferreon, A. C. M.; Gambin, Y.; Lemke, E. A.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 14
α-Synuclein-synaptosomal membrane interactions: Implications for fibrillogenesis
journal, July 2004
- Jo, Euijung; Darabie, Audrey A.; Han, Kyung
- European Journal of Biochemistry, Vol. 271, Issue 15
The new mutation, E46K, of α-synuclein causes parkinson and Lewy body dementia: New α-Synuclein Gene Mutation
journal, December 2003
- Zarranz, Juan J.; Alegre, Javier; Gómez-Esteban, Juan C.
- Annals of Neurology, Vol. 55, Issue 2
Biophysics of Parkinsons Disease: Structure and Aggregation of α- Synuclein
journal, October 2009
- Uversky, Vladimir; Eliezer, David
- Current Protein & Peptide Science, Vol. 10, Issue 5
Structural Characterization of Flexible Proteins Using Small-Angle X-ray Scattering
journal, May 2007
- Bernadó, Pau; Mylonas, Efstratios; Petoukhov, Maxim V.
- Journal of the American Chemical Society, Vol. 129, Issue 17
Linking folding and binding
journal, February 2009
- Wright, Peter E.; Dyson, H. Jane
- Current Opinion in Structural Biology, Vol. 19, Issue 1
The Aggregation and Fibrillation of α-Synuclein
journal, September 2006
- Fink, Anthony L.
- Accounts of Chemical Research, Vol. 39, Issue 9
Neurobiology of α-Synuclein
journal, January 2004
- Vekrellis, Kostas; Rideout, Hardy J.; Stefanis, Leonidas
- Molecular Neurobiology, Vol. 30, Issue 1
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
journal, February 2013
- Kiely, Aoife P.; Asi, Yasmine T.; Kara, Eleanna
- Acta Neuropathologica, Vol. 125, Issue 5
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution
journal, August 2007
- Putnam, Christopher D.; Hammel, Michal; Hura, Greg L.
- Quarterly Reviews of Biophysics, Vol. 40, Issue 3
Structure Determination of Functional Membrane Proteins using Small-Angle Neutron Scattering (SANS) with Small, Mixed-Lipid Liposomes: Native Beef Heart Mitochondrial Cytochrome c Oxidase Forms Dimers
journal, November 2012
- Rubinson, Kenneth A.; Pokalsky, Christine; Krueger, Susan
- The Protein Journal, Vol. 32, Issue 1
Lipids do influence protein function—the hydrophobic matching hypothesis revisited
journal, November 2004
- Jensen, Morten Ø.; Mouritsen, Ole G.
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1666, Issue 1-2
The role of lipid–protein interactions in amyloid-type protein fibril formation
journal, June 2006
- Gorbenko, Galyna P.; Kinnunen, Paavo K. J.
- Chemistry and Physics of Lipids, Vol. 141, Issue 1-2
Alpha-synuclein: from secretion to dysfunction and death
journal, July 2012
- Marques, O.; Outeiro, T. F.
- Cell Death & Disease, Vol. 3, Issue 7
α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease
journal, November 2010
- Auluck, Pavan K.; Caraveo, Gabriela; Lindquist, Susan
- Annual Review of Cell and Developmental Biology, Vol. 26, Issue 1
Irena : tool suite for modeling and analysis of small-angle scattering
journal, February 2009
- Ilavsky, Jan; Jemian, Peter R.
- Journal of Applied Crystallography, Vol. 42, Issue 2
Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease
journal, June 1997
- Polymeropoulos, M. H.
- Science, Vol. 276, Issue 5321
How random is a highly denatured protein?
journal, December 1994
- Calmettes, P.; Durand, D.; Desmadril, M.
- Biophysical Chemistry, Vol. 53, Issue 1-2
How Random are Intrinsically Disordered Proteins? A Small Angle Scattering Perspective
journal, February 2012
- Receveur-Brechot, Veronique; Durand, Dominique
- Current Protein & Peptide Science, Vol. 13, Issue 1
Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy
journal, July 2009
- Bodner, Christina R.; Dobson, Christopher M.; Bax, Ad
- Journal of Molecular Biology, Vol. 390, Issue 4
Understanding protein non-folding
journal, June 2010
- Uversky, Vladimir N.; Dunker, A. Keith
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1804, Issue 6
Mass fractal dimension and the compactness of proteins
journal, January 2005
- Enright, Matthew B.; Leitner, David M.
- Physical Review E, Vol. 71, Issue 1
Determination of branch fraction and minimum dimension of mass-fractal aggregates
journal, September 2004
- Beaucage, G.
- Physical Review E, Vol. 70, Issue 3
Reassessing random-coil statistics in unfolded proteins
journal, August 2004
- Fitzkee, N. C.; Rose, G. D.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 34
In vivo demonstration that -synuclein oligomers are toxic
journal, February 2011
- Winner, B.; Jappelli, R.; Maji, S. K.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 10
A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
journal, September 2014
- Pasanen, Petra; Myllykangas, Liisa; Siitonen, Maija
- Neurobiology of Aging, Vol. 35, Issue 9
A Stable Lipid-Induced Aggregate of α-Synuclein
journal, March 2010
- Drescher, Malte; Rooijen, Bart D. van; Veldhuis, Gertjan
- Journal of the American Chemical Society, Vol. 132, Issue 12
Estimation of Protein Secondary Structure from Circular Dichroism Spectra: Comparison of CONTIN, SELCON, and CDSSTR Methods with an Expanded Reference Set
journal, December 2000
- Sreerama, Narasimha; Woody, Robert W.
- Analytical Biochemistry, Vol. 287, Issue 2, p. 252-260
Quantitative investigations of aggregate systems
journal, July 2012
- Rai, D. K.; Beaucage, G.; Jonah, E. O.
- The Journal of Chemical Physics, Vol. 137, Issue 4
Explaining the Structural Plasticity of α-Synuclein
journal, December 2011
- Ullman, Orly; Fisher, Charles K.; Stultz, Collin M.
- Journal of the American Chemical Society, Vol. 133, Issue 48
Small-Angle Scattering from Polymeric Mass Fractals of Arbitrary Mass-Fractal Dimension
journal, April 1996
- Beaucage, G.
- Journal of Applied Crystallography, Vol. 29, Issue 2
A new method for purification of recombinant human α-synuclein in Escherichia coli
journal, July 2005
- Huang, Chunjuan; Ren, Guoping; Zhou, Hui
- Protein Expression and Purification, Vol. 42, Issue 1
Mechanism of thioflavin T binding to amyloid fibrils
journal, September 2005
- Khurana, Ritu; Coleman, Chris; Ionescu-Zanetti, Cristian
- Journal of Structural Biology, Vol. 151, Issue 3
Membrane Lipid Co-Aggregation with α-Synuclein Fibrils
journal, October 2013
- Hellstrand, Erik; Nowacka, Agnieszka; Topgaard, Daniel
- PLoS ONE, Vol. 8, Issue 10
Depth of α-Synuclein in a Bilayer Determined by Fluorescence, Neutron Reflectometry, and Computation
journal, February 2012
- Pfefferkorn, Candace M.; Heinrich, Frank; Sodt, Alexander J.
- Biophysical Journal, Vol. 102, Issue 3
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour
journal, May 2014
- Fusco, Giuliana; De Simone, Alfonso; Gopinath, Tata
- Nature Communications, Vol. 5, Issue 1
Intrinsically unstructured proteins
journal, October 2002
- Tompa, Peter
- Trends in Biochemical Sciences, Vol. 27, Issue 10
Deducing conformational variability of intrinsically disordered proteins from infrared spectroscopy with Bayesian statistics
journal, August 2013
- Sethi, Anurag; Anunciado, Divina; Tian, Jianhui
- Chemical Physics, Vol. 422
The Influence of Vesicle Size and Composition on α-Synuclein Structure and Stability
journal, April 2009
- Kjaer, Lars; Giehm, Lise; Heimburg, Thomas
- Biophysical Journal, Vol. 96, Issue 7
Structural and functional characterization of two alpha-synuclein strains
journal, October 2013
- Bousset, Luc; Pieri, Laura; Ruiz-Arlandis, Gemma
- Nature Communications, Vol. 4, Issue 1
Mechanism of Membrane Interaction and Disruption by α-Synuclein
journal, December 2011
- Reynolds, Nicholas P.; Soragni, Alice; Rabe, Michael
- Journal of the American Chemical Society, Vol. 133, Issue 48
Surface-induced phase separation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Aβ oligomerization
journal, June 2010
- Mao, Yanli; Shang, Zhiguo; Imai, Yosuke
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1798, Issue 6
Approximations Leading to a Unified Exponential/Power-Law Approach to Small-Angle Scattering
journal, December 1995
- Beaucage, G.
- Journal of Applied Crystallography, Vol. 28, Issue 6
Biophysical Properties of the Synucleins and Their Propensities to Fibrillate
journal, April 2002
- Uversky, Vladimir N.; Li, Jie; Souillac, Pierre
- Journal of Biological Chemistry, Vol. 277, Issue 14
α-Synuclein Membrane Interactions and Lipid Specificity
journal, November 2000
- Jo, Euijung; McLaurin, JoAnne; Yip, Christopher M.
- Journal of Biological Chemistry, Vol. 275, Issue 44
A Broken α-Helix in Folded α-Synuclein
journal, April 2003
- Chandra, Sreeganga; Chen, Xiaocheng; Rizo, Josep
- Journal of Biological Chemistry, Vol. 278, Issue 17
Structural insights on physiological functions and pathological effects of α-synuclein
journal, February 2009
- Bisaglia, Marco; Mammi, Stefano; Bubacco, Luigi
- The FASEB Journal, Vol. 23, Issue 2
Missing pieces in the Parkinson's disease puzzle
journal, May 2010
- Obeso, Jose A.; Rodriguez-Oroz, Maria C.; Goetz, Christopher G.
- Nature Medicine, Vol. 16, Issue 6
Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region
journal, October 2008
- Herrera, Fernando E.; Chesi, Alessandra; Paleologou, Katerina E.
- PLoS ONE, Vol. 3, Issue 10
Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation
journal, January 2011
- Arce, Fernando Terán; Jang, Hyunbum; Ramachandran, Srinivasan
- Soft Matter, Vol. 7, Issue 11
The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding
journal, October 2010
- Bartels, Tim; Ahlstrom, Logan S.; Leftin, Avigdor
- Biophysical Journal, Vol. 99, Issue 7
Intrinsically disordered proteins from A to Z
journal, August 2011
- Uversky, Vladimir N.
- The International Journal of Biochemistry & Cell Biology, Vol. 43, Issue 8
Small-angle scattering of biological structures
journal, October 1978
- Stuhrmann, H. B.; Miller, A.
- Journal of Applied Crystallography, Vol. 11, Issue 5
Persistence Length of Isotactic Poly(hydroxy butyrate)
journal, July 1997
- Beaucage, G.; Rane, S.; Sukumaran, S.
- Macromolecules, Vol. 30, Issue 14
Conformational characterization of a protein complex involving intrinsically disordered protein by small-angle neutron scattering using the inverse contrast matching method: a case study of interaction between α-synuclein and PbaB tetramer as a model chaperone
journal, January 2014
- Sugiyama, Masaaki; Yagi, Hirokazu; Yamaguchi, Takumi
- Journal of Applied Crystallography, Vol. 47, Issue 1
Particle size distributions from small-angle scattering using global scattering functions
journal, July 2004
- Beaucage, G.; Kammler, H. K.; Pratsinis, S. E.
- Journal of Applied Crystallography, Vol. 37, Issue 4
Mechanistic aspects of Parkinson’s disease: α-synuclein and the biomembrane
journal, April 2007
- Beyer, Klaus
- Cell Biochemistry and Biophysics, Vol. 47, Issue 2
Probing the interplay between amyloidogenic proteins and membranes using lipid monolayers and bilayers
journal, May 2014
- Relini, Annalisa; Marano, Nadia; Gliozzi, Alessandra
- Advances in Colloid and Interface Science, Vol. 207
NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded †
journal, January 1996
- Weinreb, Paul H.; Zhen, Weiguo; Poon, Anna W.
- Biochemistry, Vol. 35, Issue 43
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease: α- Synuclein p.H50q, A Novel Mutation For Pd
journal, March 2013
- Appel-Cresswell, Silke; Vilarino-Guell, Carles; Encarnacion, Mary
- Movement Disorders, Vol. 28, Issue 6
The Bio-SANS instrument at the High Flux Isotope Reactor of Oak Ridge National Laboratory
journal, June 2014
- Heller, William T.; Urban, Volker S.; Lynn, Gary W.
- Journal of Applied Crystallography, Vol. 47, Issue 4
Membrane Association and Protein Conformation of α-Synuclein in Intact Neurons
journal, March 2000
- McLean, Pamela J.; Kawamata, Hibiki; Ribich, Scott
- Journal of Biological Chemistry, Vol. 275, Issue 12
Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level
journal, January 2008
- Sandal, Massimo; Valle, Francesco; Tessari, Isabella
- PLoS Biology, Vol. 6, Issue 1
Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes
journal, April 1998
- Davidson, W. Sean; Jonas, Ana; Clayton, David F.
- Journal of Biological Chemistry, Vol. 273, Issue 16
SAXS Study of the PIR Domain from the Grb14 Molecular Adaptor: A Natively Unfolded Protein with a Transient Structure Primer?
journal, December 2004
- Moncoq, K.; Broutin, I.; Craescu, C. T.
- Biophysical Journal, Vol. 87, Issue 6
Adsorption of α-Synuclein to Supported Lipid Bilayers: Positioning and Role of Electrostatics
journal, July 2013
- Hellstrand, Erik; Grey, Marie; Ainalem, Marie-Louise
- ACS Chemical Neuroscience, Vol. 4, Issue 10