Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)
- Authors:
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1250600
- Grant/Contract Number:
- AC02-06CH11357
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Bioorganic and Medicinal Chemistry
- Additional Journal Information:
- Journal Name: Bioorganic and Medicinal Chemistry Journal Volume: 23 Journal Issue: 17; Journal ID: ISSN 0968-0896
- Publisher:
- Elsevier
- Country of Publication:
- United Kingdom
- Language:
- English
Citation Formats
St. John, Sarah E., Tomar, Sakshi, Stauffer, Shaun R., and Mesecar, Andrew D. Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). United Kingdom: N. p., 2015.
Web. doi:10.1016/j.bmc.2015.06.039.
St. John, Sarah E., Tomar, Sakshi, Stauffer, Shaun R., & Mesecar, Andrew D. Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). United Kingdom. https://doi.org/10.1016/j.bmc.2015.06.039
St. John, Sarah E., Tomar, Sakshi, Stauffer, Shaun R., and Mesecar, Andrew D. Tue .
"Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)". United Kingdom. https://doi.org/10.1016/j.bmc.2015.06.039.
@article{osti_1250600,
title = {Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)},
author = {St. John, Sarah E. and Tomar, Sakshi and Stauffer, Shaun R. and Mesecar, Andrew D.},
abstractNote = {},
doi = {10.1016/j.bmc.2015.06.039},
journal = {Bioorganic and Medicinal Chemistry},
number = 17,
volume = 23,
place = {United Kingdom},
year = {Tue Sep 01 00:00:00 EDT 2015},
month = {Tue Sep 01 00:00:00 EDT 2015}
}
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https://doi.org/10.1016/j.bmc.2015.06.039
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Works referenced in this record:
Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage
journal, August 2003
- Snijder, Eric J.; Bredenbeek, Peter J.; Dobbe, Jessika C.
- Journal of Molecular Biology, Vol. 331, Issue 5
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
journal, November 2012
- Zaki, Ali M.; van Boheemen, Sander; Bestebroer, Theo M.
- New England Journal of Medicine, Vol. 367, Issue 19
Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist
journal, September 2013
- Niemeyer, D.; Zillinger, T.; Muth, D.
- Journal of Virology, Vol. 87, Issue 22
Comparisons of the interactions of benzene, furan and thiophene with Lewis acids: the rotational spectrum of thiophene⋯HF
journal, July 1998
- Cooke, S. A.; Corlett, G. K.; Legon, A. C.
- Chemical Physics Letters, Vol. 291, Issue 3-4
Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs
journal, June 2003
- Anand, K.
- Science, Vol. 300, Issue 5626
Rotational spectrum of thiophene···HCl Does thiophene act as an aromatic π-type electron donor or an n-type electron donor in hydrogen-bond formation?
journal, January 1998
- Cooke, Stephen A.; Corlett, Gary K.; Legon, A. C.
- Journal of the Chemical Society, Faraday Transactions, Vol. 94, Issue 11
The p K BHX Database: Toward a Better Understanding of Hydrogen-Bond Basicity for Medicinal Chemists
journal, July 2009
- Laurence, Christian; Brameld, Ken A.; Graton, Jérôme
- Journal of Medicinal Chemistry, Vol. 52, Issue 14
Comparative Analysis of Twelve Genomes of Three Novel Group 2c and Group 2d Coronaviruses Reveals Unique Group and Subgroup Features
journal, November 2006
- Woo, Patrick C. Y.; Wang, Ming; Lau, Susanna K. P.
- Journal of Virology, Vol. 81, Issue 4
The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling
journal, January 2014
- Matthews, K. L.; Coleman, C. M.; van der Meer, Y.
- Journal of General Virology, Vol. 95, Issue Pt_4
Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia
journal, November 2013
- Memish, Ziad A.; Mishra, Nischay; Olival, Kevin J.
- Emerging Infectious Diseases, Vol. 19, Issue 11
Mechanisms and enzymes involved in SARS coronavirus genome expression
journal, September 2003
- Thiel, Volker; Ivanov, Konstantin A.; Putics, Ákos
- Journal of General Virology, Vol. 84, Issue 9
PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010
- Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model
journal, September 2012
- Greenblatt, Matthew B.; Vbranac, Vladimir; Tivey, Trevor
- PLoS ONE, Vol. 7, Issue 9
A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
journal, May 2003
- Ksiazek, Thomas G.; Erdman, Dean; Goldsmith, Cynthia S.
- New England Journal of Medicine, Vol. 348, Issue 20, p. 1953-1966
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group
journal, May 2013
- de Groot, R. J.; Baker, S. C.; Baric, R. S.
- Journal of Virology, Vol. 87, Issue 14
ESPript/ENDscript: extracting and rendering sequence and 3D information from atomic structures of proteins
journal, July 2003
- Gouet, P.
- Nucleic Acids Research, Vol. 31, Issue 13
Coronaviruses post-SARS: update on replication and pathogenesis
journal, May 2009
- Perlman, Stanley; Netland, Jason
- Nature Reviews Microbiology, Vol. 7, Issue 6
Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation
journal, February 2014
- Haagmans, Bart L.; Al Dhahiry, Said H. S.; Reusken, Chantal B. E. M.
- The Lancet Infectious Diseases, Vol. 14, Issue 2
Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26
journal, September 2014
- Wang, Qihui; Qi, Jianxun; Yuan, Yuan
- Cell Host & Microbe, Vol. 16, Issue 3
Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
journal, January 2013
- Jacobs, Jon; Grum-Tokars, Valerie; Zhou, Ya
- Journal of Medicinal Chemistry, Vol. 56, Issue 2
Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome
journal, May 2003
- Drosten, Christian; Günther, Stephan; Preiser, Wolfgang
- New England Journal of Medicine, Vol. 348, Issue 20
The rotational spectrum of thiophene⋯HBr and a comparison of the geometries of the complexes B⋯HX, where B is benzene, furan or thiophene and X is F, Cl or Br
journal, January 2004
- Legon, A. C.; Ottaviani, P.
- Phys. Chem. Chem. Phys., Vol. 6, Issue 3
ESPript: analysis of multiple sequence alignments in PostScript
journal, April 1999
- Gouet, P.; Courcelle, E.; Stuart, D.
- Bioinformatics, Vol. 15, Issue 4
The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns”
journal, July 2013
- Chan, Jasper Fuk-Woo; Lau, Susanna Kar-Pui; Woo, Patrick Chiu-Yat
- Journal of the Formosan Medical Association, Vol. 112, Issue 7
Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease
journal, March 2006
- Wu, Chung-Yi; King, Ke-Yung; Kuo, Chih-Jung
- Chemistry & Biology, Vol. 13, Issue 3
Nidovirales: Evolving the largest RNA virus genome
journal, April 2006
- Gorbalenya, Alexander E.; Enjuanes, Luis; Ziebuhr, John
- Virus Research, Vol. 117, Issue 1
Virus-encoded proteinases and proteolytic processing in the Nidovirales
journal, April 2000
- Gorbalenya, Alexander E.; Snijder, Eric J.; Ziebuhr, John
- Journal of General Virology, Vol. 81, Issue 4
Not much to malign multalin 4.0
journal, March 1993
- Cockerill, Matthew
- Trends in Biochemical Sciences, Vol. 18, Issue 3
Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease.
journal, April 1967
- McIntosh, K.; Dees, J. H.; Becker, W. B.
- Proceedings of the National Academy of Sciences, Vol. 57, Issue 4
Viral Replicase Gene Products Suffice for Coronavirus Discontinuous Transcription
journal, July 2001
- Thiel, Volker; Herold, Jens; Schelle, Barbara
- Journal of Virology, Vol. 75, Issue 14
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
journal, November 2013
- Turlington, Mark; Chun, Aspen; Tomar, Sakshi
- Bioorganic & Medicinal Chemistry Letters, Vol. 23, Issue 22