Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes
Abstract
The production of positron-emitting isotopes of manganese is potentially important for developing contrast agents for dual-modality positron emission tomography and magnetic resonance (PET/MR) imaging, as well as for in vivo imaging of the biodistribution and toxicity of manganese. Furthermore, the decay properties of 52Mn make it an excellent candidate for these applications, and it can easily be produced by bombardment of a chromium target with protons or deuterons from a low-energy biomedical cyclotron. There are several parameters essential to this mode of production—target thickness, beam energy, beam current, and bombardment time—depend heavily on the availability of reliable, reproducible cross-section data. Our paper contributes to the routine production of 52gMn for biomedical research by contributing experimental cross-sections for natural chromium (natCr) targets for the natCr(p,x)52gMn reaction, as well as for the production of the radiocontaminants 52m,54Mn.
- Authors:
-
- Washington Univ., St. Louis, MO (United States). Dept. of Biomedical Engineering; Washington Univ. School of Medicine, St. Louis, MO (United States). Mallinckrodt Inst. of Radiology
- Washington Univ. School of Medicine, St. Louis, MO (United States). Mallinckrodt Inst. of Radiology
- Publication Date:
- Research Org.:
- Washington Univ., St. Louis, MO (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)
- OSTI Identifier:
- 1344116
- Alternate Identifier(s):
- OSTI ID: 1250574
- Grant/Contract Number:
- NA0000979
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Applied Radiation and Isotopes
- Additional Journal Information:
- Journal Volume: 96; Journal Issue: C; Journal ID: ISSN 0969-8043
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 07 ISOTOPE AND RADIATION SOURCES; 52Mn; 52mMn; 54Mn; Cross-section; Solid target; Radiometal; PET isotopes; Isotope production
Citation Formats
Wooten, A. Lake, Lewis, Benjamin C., and Lapi, Suzanne E. Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes. United States: N. p., 2014.
Web. doi:10.1016/j.apradiso.2014.12.001.
Wooten, A. Lake, Lewis, Benjamin C., & Lapi, Suzanne E. Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes. United States. https://doi.org/10.1016/j.apradiso.2014.12.001
Wooten, A. Lake, Lewis, Benjamin C., and Lapi, Suzanne E. Thu .
"Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes". United States. https://doi.org/10.1016/j.apradiso.2014.12.001. https://www.osti.gov/servlets/purl/1344116.
@article{osti_1344116,
title = {Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes},
author = {Wooten, A. Lake and Lewis, Benjamin C. and Lapi, Suzanne E.},
abstractNote = {The production of positron-emitting isotopes of manganese is potentially important for developing contrast agents for dual-modality positron emission tomography and magnetic resonance (PET/MR) imaging, as well as for in vivo imaging of the biodistribution and toxicity of manganese. Furthermore, the decay properties of 52Mn make it an excellent candidate for these applications, and it can easily be produced by bombardment of a chromium target with protons or deuterons from a low-energy biomedical cyclotron. There are several parameters essential to this mode of production—target thickness, beam energy, beam current, and bombardment time—depend heavily on the availability of reliable, reproducible cross-section data. Our paper contributes to the routine production of 52gMn for biomedical research by contributing experimental cross-sections for natural chromium (natCr) targets for the natCr(p,x)52gMn reaction, as well as for the production of the radiocontaminants 52m,54Mn.},
doi = {10.1016/j.apradiso.2014.12.001},
journal = {Applied Radiation and Isotopes},
number = C,
volume = 96,
place = {United States},
year = {Thu Dec 11 00:00:00 EST 2014},
month = {Thu Dec 11 00:00:00 EST 2014}
}
Web of Science
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