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Title: Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma

Here, primary effusion lymphoma (PEL) is a rare large B-cell neoplasm particularly affecting immunodeficient hosts with an increased incidence in young or middle-aged males infected with the HIV.1 The clinical outcome of patients with PEL is unfavorable with a median survival of <6 months.1 PEL has been closely associated with human herpes virus 8 (HHV8, previously called Kaposi sarcoma herpesvirus) infection.1 In some cases a coinfection of HHV8 with the Epstein–Barr Virus (EBV) has been described.1 HHV8 encodes various genes homologous to cellular genes that have proliferative and anti-apoptotic functions.2 Although HHV8 is supposed to be a major driver of PEL, it alone is not sufficient for a full-blown lymphomagenesis.2 PEL usually shows complex karyotypes with many chromosomal aberrations.3 This chromosomal complexity might be driven by the viral infection and lead to genetic alterations cooperating with HHV8 in PEL lymphomagenesis.4
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [1] ;  [5] ;  [1] ;  [6] ;  [6] ;  [1]
  1. Univ. Hospital Schleswig-Holstein, Christian-Albrechts-Univ., Kiel (Germany)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Univ. Hospital of Cologne, Cologne (Germany)
  4. Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Heidelberg (Germany)
  5. Leibniz-Institute DSMZ, Braunschweig (Germany)
  6. Wellcome Trust Cancer Sanger Institute, Hinxton (United Kingdom)
Publication Date:
OSTI Identifier:
1248630
Report Number(s):
LA-UR--15-20054
Journal ID: ISSN 0887-6924; leu201522
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Leukemia
Additional Journal Information:
Journal Volume: 29; Journal Issue: 7; Journal ID: ISSN 0887-6924
Publisher:
Nature Publishing Group (NPG)
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES