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Title: Analysis of biosurfaces by neutron reflectometry: From simple to complex interfaces

Because of its high sensitivity for light elements and the scattering contrast manipulation via isotopic substitutions, neutron reflectometry (NR) is an excellent tool for studying the structure of soft-condensed material. These materials include model biophysical systems as well as in situ living tissue at the solid–liquid interface. The penetrability of neutrons makes NR suitable for probing thin films with thicknesses of 5–5000 Å at various buried, for example, solid–liquid, interfaces [J. Daillant and A. Gibaud, Lect. Notes Phys. 770, 133 (2009); G. Fragneto-Cusani, J. Phys.: Condens. Matter 13, 4973 (2001); J. Penfold, Curr. Opin. Colloid Interface Sci. 7, 139 (2002)]. Over the past two decades, NR has evolved to become a key tool in the characterization of biological and biomimetic thin films. Highlighted In the current report are some of the authors' recent accomplishments in utilizing NR to study highly complex systems, including in-situ experiments. Such studies will result in a much better understanding of complex biological problems, have significant medical impact by suggesting innovative treatment, and advance the development of highly functionalized biomimetic materials.
Authors:
 [1] ;  [2] ;  [3] ;  [1] ;  [4] ;  [5] ;  [6] ;  [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States) Center for Integrated Nanotechnologies (MPA-CINT), Lujan Neutron Scattering Center
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Los Alamos Neutron Science Center (LANSCE), Lujan Neutron Scattering Center; Inst. Laue-Langevin (ILL), Grenoble (France)
  3. Inst. Laue-Langevin (ILL), Grenoble (France)
  4. Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Biosciences Division, Bioenergy and Biome Sciences
  5. California Inst. of Technology (CalTech), Pasadena, CA (United States). Dept. of Applied Physics
  6. Univ. of Pittsburgh, PA (United States). Department of Surgery
Publication Date:
OSTI Identifier:
1248580
Report Number(s):
LA-UR--14-29503
Journal ID: ISSN 1934-8630; BJIOBN
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Biointerphases
Additional Journal Information:
Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 1934-8630
Publisher:
AIP
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS; 36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY neutron scattering, neutron reflectometry, model membranes, lipid bilayers, live cells