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This content will become publicly available on January 5, 2017

Title: Shock wave induced damage of a protein by void collapse

In this study, we report on a series of molecular dynamics simulations that were used to examine the effects of shockwaves on a membrane bound ion channel. A planar shockwave was found to compress the ion channel upon impact but the protein geometry resembles the initial structure as soon as the solvent density begins to dissipate. When a void was placed in close proximity to the membrane, the shockwave proved to be much more destructive to the protein due to formation of a nanojet that results from the asymmetric collapse of the void. The nanojet was able to cause significant structural changes to the protein even at low particle velocities that are not able to directly cause poration of the membrane.
Authors:
 [1] ;  [2] ;  [1]
  1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  2. Univ. of North Carolina, Chapel Hill, NC (United States)
Publication Date:
OSTI Identifier:
1241952
Report Number(s):
LLNL--JRNL-671538
Journal ID: ISSN 0006-3495
Grant/Contract Number:
AC52-07NA27344
Type:
Accepted Manuscript
Journal Name:
Biophysical Journal
Additional Journal Information:
Journal Volume: 110; Journal Issue: 1; Journal ID: ISSN 0006-3495
Publisher:
Elsevier
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES