Identification of a novel nematotoxic protein by challenging the model mushroom Coprinopsis cinerea with a fungivorous nematode
Abstract
The dung of herbivores, the natural habitat of the model mushroom Coprinopsis cinerea, is a nutrient-rich but also very competitive environment for a saprophytic fungus. Previously we showed that C. cinerea expresses constitutive, tissue-specific armories against antagonists such as animal predators and bacterial competitors. In order to dissect the inducible armories against such antagonists, we sequenced the poly(A)-positive transcriptome of C. cinerea vegetative mycelium upon challenge with fungivorous and bacterivorous nematodes, Gram-negative and Gram-positive bacteria and mechanical damage. As a response to the fungivorous nematode Aphelenchus avenae, C. cinerea was found to specifically induce the transcription of several genes encoding previously characterized nematotoxic lectins. In addition, a previously not characterized gene encoding a cytoplasmic protein with several predicted Ricin B-fold domains, was found to be strongly up-regulated under this condition. Functional analysis of the recombinant protein revealed a high toxicity towards the bacterivorous nematode Caenorhabditis elegans. Challenge of the mycelium with A. avenae also lead to the induction of several genes encoding putative antibacterial proteins. Some of these genes were also induced upon challenge of the mycelium with the bacteria Escherichia coli and Bacillus subtilis. Lastly, these results suggest that fungi have the ability to induce specific innate defense responsesmore »
- Authors:
-
- ETH Zurich, Zurich (Switzerland)
- Joint Genome Institute, Walnut Creek, California (United States)
- Publication Date:
- Research Org.:
- Univ. of California (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1239250
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- G3
- Additional Journal Information:
- Journal Volume: 6; Journal Issue: 1; Journal ID: ISSN 2160-1836
- Publisher:
- Genetics Society of America
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; basidiomycete; fungal defense; RNA sequencing; CCTX2; transcriptomics
Citation Formats
Plaza, David Fernando, Schmieder, Stefanie Sofia, Lipzen, Anna, Lindquist, Erika, and Künzler, Markus. Identification of a novel nematotoxic protein by challenging the model mushroom Coprinopsis cinerea with a fungivorous nematode. United States: N. p., 2015.
Web. doi:10.1534/g3.115.023069.
Plaza, David Fernando, Schmieder, Stefanie Sofia, Lipzen, Anna, Lindquist, Erika, & Künzler, Markus. Identification of a novel nematotoxic protein by challenging the model mushroom Coprinopsis cinerea with a fungivorous nematode. United States. https://doi.org/10.1534/g3.115.023069
Plaza, David Fernando, Schmieder, Stefanie Sofia, Lipzen, Anna, Lindquist, Erika, and Künzler, Markus. Thu .
"Identification of a novel nematotoxic protein by challenging the model mushroom Coprinopsis cinerea with a fungivorous nematode". United States. https://doi.org/10.1534/g3.115.023069. https://www.osti.gov/servlets/purl/1239250.
@article{osti_1239250,
title = {Identification of a novel nematotoxic protein by challenging the model mushroom Coprinopsis cinerea with a fungivorous nematode},
author = {Plaza, David Fernando and Schmieder, Stefanie Sofia and Lipzen, Anna and Lindquist, Erika and Künzler, Markus},
abstractNote = {The dung of herbivores, the natural habitat of the model mushroom Coprinopsis cinerea, is a nutrient-rich but also very competitive environment for a saprophytic fungus. Previously we showed that C. cinerea expresses constitutive, tissue-specific armories against antagonists such as animal predators and bacterial competitors. In order to dissect the inducible armories against such antagonists, we sequenced the poly(A)-positive transcriptome of C. cinerea vegetative mycelium upon challenge with fungivorous and bacterivorous nematodes, Gram-negative and Gram-positive bacteria and mechanical damage. As a response to the fungivorous nematode Aphelenchus avenae, C. cinerea was found to specifically induce the transcription of several genes encoding previously characterized nematotoxic lectins. In addition, a previously not characterized gene encoding a cytoplasmic protein with several predicted Ricin B-fold domains, was found to be strongly up-regulated under this condition. Functional analysis of the recombinant protein revealed a high toxicity towards the bacterivorous nematode Caenorhabditis elegans. Challenge of the mycelium with A. avenae also lead to the induction of several genes encoding putative antibacterial proteins. Some of these genes were also induced upon challenge of the mycelium with the bacteria Escherichia coli and Bacillus subtilis. Lastly, these results suggest that fungi have the ability to induce specific innate defense responses similar to plants and animals.},
doi = {10.1534/g3.115.023069},
journal = {G3},
number = 1,
volume = 6,
place = {United States},
year = {Thu Nov 19 00:00:00 EST 2015},
month = {Thu Nov 19 00:00:00 EST 2015}
}
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Plant Immunity to Insect Herbivores
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Selection of reference genes for quantitative real-time PCR in a rat asphyxial cardiac arrest model
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- BMC Molecular Biology, Vol. 9, Issue 1
Caenorhabditis elegans N-glycan Core β-galactoside Confers Sensitivity towards Nematotoxic Fungal Galectin CGL2
journal, January 2010
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- PLoS Pathogens, Vol. 6, Issue 1
Plasticity of the β-Trefoil Protein Fold in the Recognition and Control of Invertebrate Predators and Parasites by a Fungal Defence System
journal, May 2012
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Overview on Plant Antimicrobial Peptides
journal, May 2010
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A lectin-mediated resistance of higher fungi against predators and parasites
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- ETH Zurich
Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to bacteria
text, January 2019
- Kombrink, Anja; Tayyrov, Annageldi; Essig, Andreas
- Nature Publishing Group
Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to bacteria
text, January 2018
- Kombrink, Anja; Tayyrov, Annageldi; Essig, Andreas
- ETH Zurich
Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to bacteria
journal, October 2018
- Kombrink, Anja; Tayyrov, Annageldi; Essig, Andreas
- The ISME Journal, Vol. 13, Issue 3
Caenorhabditis elegans as a Model Host to Monitor the Candida Infection Processes
journal, November 2018
- Elkabti, Asmaa; Issi, Luca; Rao, Reeta
- Journal of Fungi, Vol. 4, Issue 4