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Title: Laser machined plastic laminates. Towards portable diagnostic devices for use in low resource environments

Despite significant progress in development of bioanalytical devices cost, complexity, access to reagents and lack of infrastructure have prevented use of these technologies in resource-limited regions. To provide a sustainable tool in the global effort to combat infectious diseases the diagnostic device must be low cost, simple to operate and read, robust, and have sensitivity and specificity comparable to laboratory analysis. Thus, in this mini-review we describe recent work using laser machined plastic laminates to produce diagnostic devices that are capable of a wide variety of bioanalytical measurements and show great promise towards future use in low-resource environments.
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1]
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
OSTI Identifier:
1237655
Report Number(s):
SAND--2015-4078J
Journal ID: ISSN 1040-0397; 584060
Grant/Contract Number:
AC04-94AL85000
Type:
Accepted Manuscript
Journal Name:
Electroanalysis
Additional Journal Information:
Journal Volume: 27; Journal Issue: 11; Journal ID: ISSN 1040-0397
Publisher:
Wiley
Research Org:
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA)
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION low-resource environment bioanalytics; laser ablated plastic laminates; electrode arrays; DNA detection; orthogonal biosensor