Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity
Abstract
Our design, fabrication, and characterization of a label-free Mach–Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the slow light photonic crystal region. The numerically simulated sensitivity of a MZI sensor with a 16 μm long slow light region is 115,000 rad/RIU-cm, which is sevenfold higher than traditional MZI biosensors with millimeter-length sensing regions. Moreover, the experimental bulk refractive index detection sensitivity of 84,000 rad/RIU-cm is realized and nucleic acid detection is also demonstrated.
- Authors:
-
- Vanderbilt Univ., Nashville, TN (United States)
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Publication Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1237162
- Grant/Contract Number:
- AC05-00OR22725
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Optics Letters
- Additional Journal Information:
- Journal Volume: 41; Journal Issue: 4; Journal ID: ISSN 0146-9592
- Publisher:
- Optical Society of America (OSA)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION; 59 BASIC BIOLOGICAL SCIENCES; biological sensing and sensors; photonic bandgap materials; subwavelength structures; nanostructures; interference
Citation Formats
Qin, Kun, Hu, Shuren, Retterer, Scott T., Kravchenko, Ivan I., and Weiss, Sharon M. Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity. United States: N. p., 2016.
Web. doi:10.1364/OL.41.000753.
Qin, Kun, Hu, Shuren, Retterer, Scott T., Kravchenko, Ivan I., & Weiss, Sharon M. Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity. United States. https://doi.org/10.1364/OL.41.000753
Qin, Kun, Hu, Shuren, Retterer, Scott T., Kravchenko, Ivan I., and Weiss, Sharon M. Fri .
"Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity". United States. https://doi.org/10.1364/OL.41.000753. https://www.osti.gov/servlets/purl/1237162.
@article{osti_1237162,
title = {Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity},
author = {Qin, Kun and Hu, Shuren and Retterer, Scott T. and Kravchenko, Ivan I. and Weiss, Sharon M.},
abstractNote = {Our design, fabrication, and characterization of a label-free Mach–Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the slow light photonic crystal region. The numerically simulated sensitivity of a MZI sensor with a 16 μm long slow light region is 115,000 rad/RIU-cm, which is sevenfold higher than traditional MZI biosensors with millimeter-length sensing regions. Moreover, the experimental bulk refractive index detection sensitivity of 84,000 rad/RIU-cm is realized and nucleic acid detection is also demonstrated.},
doi = {10.1364/OL.41.000753},
journal = {Optics Letters},
number = 4,
volume = 41,
place = {United States},
year = {Fri Feb 05 00:00:00 EST 2016},
month = {Fri Feb 05 00:00:00 EST 2016}
}
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