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Title: Tracking single-particle rotation during macrophage uptake

We investigated the rotational dynamics of single microparticles during their internalization by macrophage cells. The microparticles used were triblock patchy particles that display two fluorescent patches on their two poles. The optical anisotropy made it possible to directly visualize and quantify the orientation and rotation of the particles. We show that particles exhibit a mixture of fast and slow rotation as they are uptaken by macrophages and transiently undergo directional rotation during their entry into the cell. As a result, the size of the particles and the surface presentation of ligands exerted a negligible influence on this heterogeneity of particle rotation.
Authors:
 [1] ;  [1] ;  [2] ;  [1] ;  [1]
  1. Indiana Univ., Bloomington, IN (United States)
  2. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
OSTI Identifier:
1235366
Report Number(s):
SAND--2015-3290J
Journal ID: ISSN 1744-683X; SMOABF; 583488
Grant/Contract Number:
AC04-94AL85000
Type:
Accepted Manuscript
Journal Name:
Soft Matter
Additional Journal Information:
Journal Volume: 11; Journal Issue: 26; Journal ID: ISSN 1744-683X
Publisher:
Royal Society of Chemistry
Research Org:
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
Indiana Univ., Bloomington, IN (United States)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY