Permeability barrier of Gram-negative cell envelopes and approaches to bypass it
Abstract
Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This article summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.
- Authors:
-
- Univ. of Oklahoma, Norman, OK (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1234255
- Report Number(s):
- LA-UR-15-27220
Journal ID: ISSN 2373-8227
- Grant/Contract Number:
- AI052293; HDTRA1-14-1-0019; AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Infectious Diseases
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 11; Journal ID: ISSN 2373-8227
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; gram-negative resistance; permeability barrier; outer membrane; multi-drug efflux
Citation Formats
Zgurskaya, Helen I., López, Cesar A., and Gnanakaran, Sandrasegaram. Permeability barrier of Gram-negative cell envelopes and approaches to bypass it. United States: N. p., 2015.
Web. doi:10.1021/acsinfecdis.5b00097.
Zgurskaya, Helen I., López, Cesar A., & Gnanakaran, Sandrasegaram. Permeability barrier of Gram-negative cell envelopes and approaches to bypass it. United States. https://doi.org/10.1021/acsinfecdis.5b00097
Zgurskaya, Helen I., López, Cesar A., and Gnanakaran, Sandrasegaram. Fri .
"Permeability barrier of Gram-negative cell envelopes and approaches to bypass it". United States. https://doi.org/10.1021/acsinfecdis.5b00097. https://www.osti.gov/servlets/purl/1234255.
@article{osti_1234255,
title = {Permeability barrier of Gram-negative cell envelopes and approaches to bypass it},
author = {Zgurskaya, Helen I. and López, Cesar A. and Gnanakaran, Sandrasegaram},
abstractNote = {Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This article summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.},
doi = {10.1021/acsinfecdis.5b00097},
journal = {ACS Infectious Diseases},
number = 11,
volume = 1,
place = {United States},
year = {Fri Sep 18 00:00:00 EDT 2015},
month = {Fri Sep 18 00:00:00 EDT 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 341 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Antibacterial resistance worldwide: causes, challenges and responses
journal, November 2004
- Levy, Stuart B.; Marshall, Bonnie
- Nature Medicine, Vol. 10, Issue S12
Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010
journal, January 2013
- Sievert, Dawn M.; Ricks, Philip; Edwards, Jonathan R.
- Infection Control & Hospital Epidemiology, Vol. 34, Issue 1
The need for new antibiotics
journal, January 2004
- Livermore, D. M.
- Clinical Microbiology and Infection, Vol. 10
Mechanisms of Resistance and Clinical Relevance of Resistance to β-Lactams, Glycopeptides, and Fluoroquinolones
journal, February 2012
- Rice, Louis B.
- Mayo Clinic Proceedings, Vol. 87, Issue 2
Emerging Issues in Gram-Negative Bacterial Resistance
journal, March 2015
- Vasoo, Shawn; Barreto, Jason N.; Tosh, Pritish K.
- Mayo Clinic Proceedings, Vol. 90, Issue 3
Challenges of Antibacterial Discovery
journal, January 2011
- Silver, L. L.
- Clinical Microbiology Reviews, Vol. 24, Issue 1
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
journal, March 2001
- Lipinski, Christopher A.; Lombardo, Franco; Dominy, Beryl W.
- Advanced Drug Delivery Reviews, Vol. 46, Issue 1-3
Guest editor introduction
journal, May 2009
- Zgurskaya, Helen I.
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1794, Issue 5
Multidrug Resistance in Bacteria
journal, June 2009
- Nikaido, Hiroshi
- Annual Review of Biochemistry, Vol. 78, Issue 1
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
journal, March 2015
- Li, Xian-Zhi; Plésiat, Patrick; Nikaido, Hiroshi
- Clinical Microbiology Reviews, Vol. 28, Issue 2
Outer membrane permeability and antibiotic resistance
journal, May 2009
- Delcour, Anne H.
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1794, Issue 5
Waltzing transporters and 'the dance macabre' between humans and bacteria
journal, December 2006
- Lomovskaya, Olga; Zgurskaya, Helen I.; Totrov, Maxim
- Nature Reviews Drug Discovery, Vol. 6, Issue 1
Multicomponent drug efflux complexes: architecture and mechanism of assembly
journal, September 2009
- Zgurskaya, Helen I.
- Future Microbiology, Vol. 4, Issue 7
In Vivo Emergence of Multidrug-Resistant Mutants of Pseudomonas aeruginosa Overexpressing the Active Efflux System MexA-MexB-OprM
journal, February 1999
- Ziha-Zarifi, Isabelle; Llanes, Catherine; Köhler, Thilo
- Antimicrobial Agents and Chemotherapy, Vol. 43, Issue 2
Expression of Multidrug Efflux Pump Genes acrAB-tolC , mdfA , and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance
journal, November 2010
- Swick, Michelle C.; Morgan-Linnell, Sonia K.; Carlson, Kimberly M.
- Antimicrobial Agents and Chemotherapy, Vol. 55, Issue 2
Klebsiella pneumoniae AcrAB Efflux Pump Contributes to Antimicrobial Resistance and Virulence
journal, January 2010
- Padilla, Emma; Llobet, Enrique; Doménech-Sánchez, Antonio
- Antimicrobial Agents and Chemotherapy, Vol. 54, Issue 1
Mechanisms of resistance to ciprofloxacin, ampicillin/sulbactam and imipenem in Acinetobacter baumannii clinical isolates in Taiwan
journal, April 2010
- Chiu, Cheng-Hsun; Lee, Hao-Yuan; Tseng, Li-Yun
- International Journal of Antimicrobial Agents, Vol. 35, Issue 4
Structure of bacterial lipopolysaccharides
journal, November 2003
- Caroff, Martine; Karibian, Doris
- Carbohydrate Research, Vol. 338, Issue 23
Structural diversity of the core oligosaccharide domain of Pseudomonas aeruginosa lipopolysaccharide
journal, July 2011
- Kocincova, D.; Lam, J. S.
- Biochemistry (Moscow), Vol. 76, Issue 7
Pseudomonas aeruginosa lipopolysaccharide: A major virulence factor, initiator of inflammation and target for effective immunity
journal, September 2007
- Pier, G.
- International Journal of Medical Microbiology, Vol. 297, Issue 5
Unique Lipid A Modifications in Pseudomonas aeruginosa Isolated from the Airways of Patients with Cystic Fibrosis
journal, October 2007
- Ernst, Robert K.; Moskowitz, Samuel M.; Emerson, Julia C.
- The Journal of Infectious Diseases, Vol. 196, Issue 7
Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4
journal, December 2003
- Ernst, Robert K.; Hajjar, Adeline M.; Tsai, Jeff H.
- Journal of Endotoxin Research, Vol. 9, Issue 6
Review: Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides
journal, June 2008
- De Soyza, Anthony; Silipo, Alba; Lanzetta, Rosa
- Innate Immunity, Vol. 14, Issue 3
Phosphoethanolamine Modification of Lipid A in Colistin-Resistant Variants of Acinetobacter baumannii Mediated by the pmrAB Two-Component Regulatory System
journal, May 2011
- Beceiro, Alejandro; Llobet, Enrique; Aranda, Jesús
- Antimicrobial Agents and Chemotherapy, Vol. 55, Issue 7
Outer membranes of Gram-negative bacteria are permeable to steroid probes
journal, May 1992
- Plésiat, Patrick; Nikaido, Hiroshi
- Molecular Microbiology, Vol. 6, Issue 10
Use of steroids to monitor alterations in the outer membrane of Pseudomonas aeruginosa
journal, November 1997
- Plesiat, P.; Aires, J. R.; Godard, C.
- Journal of Bacteriology, Vol. 179, Issue 22
Conserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosa
journal, December 2006
- Knirel, Yuriy A.; Bystrova, Olga V.; Kocharova, Nina A.
- Journal of Endotoxin Research, Vol. 12, Issue 6
Full Structure of the Lipopolysaccharide of Pseudomonas aeruginosa Immunotype 5
journal, February 2004
- Bystrova, O. V.; Lindner, B.; Moll, H.
- Biochemistry (Moscow), Vol. 69, Issue 2
Structure of the core-oligosaccharide with a characteristic d-glycero-α-d-talo-oct-2-ulosylonate-(2→4)-3-deoxy-d-manno-oct-2-ulosonate [α-Ko-(2→4)-Kdo] disaccharide in the lipopolysaccharide from Burkholderia cepacia
journal, November 2003
- Isshiki, Yasunori; Zähringer, Ulrich; Kawahara, Kazuyoshi
- Carbohydrate Research, Vol. 338, Issue 23
Structural Investigation of the Lipopolysaccharide from Acinetobacter Haemolyticus Strain NCTC 10305 (ATCC 17906, DNA Group 4)
journal, July 1997
- Vinogradov, Evgeny V.; Muller-Loennies, Sven; Petersen, Bent O.
- European Journal of Biochemistry, Vol. 247, Issue 1
Review: Lipopolysaccharide of Burkholderia cepacia complex
journal, August 2003
- Vinion-Dubiel, Arlene D.; Goldberg, Joanna B.
- Journal of Endotoxin Research, Vol. 9, Issue 4
PhoPQ-Mediated Regulation Produces a More Robust Permeability Barrier in the Outer Membrane of Salmonella enterica Serovar Typhimurium
journal, October 2007
- Murata, Takeshi; Tseng, Will; Guina, Tina
- Journal of Bacteriology, Vol. 189, Issue 20
Lipid A Modification Systems in Gram-Negative Bacteria
journal, June 2007
- Raetz, Christian R. H.; Reynolds, C. Michael; Trent, M. Stephen
- Annual Review of Biochemistry, Vol. 76, Issue 1
Regulation of Lipid A Modifications by Salmonella typhimurium Virulence Genes phoP-phoQ
journal, April 1997
- Guo, L.
- Science, Vol. 276, Issue 5310
Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria
journal, November 2014
- Olaitan, Abiola O.; Morand, Serge; Rolain, Jean-Marc
- Frontiers in Microbiology, Vol. 5
The membranes of Gram-negative bacteria: progress in molecular modelling and simulation
journal, April 2015
- Khalid, Syma; Berglund, Nils A.; Holdbrook, Daniel A.
- Biochemical Society Transactions, Vol. 43, Issue 2
Modeling the electrostatic potential of asymmetric lipopolysaccharide membranes: The MEMPOT algorithm implemented in DelPhi
journal, May 2014
- Dias, Roberta P.; Li, Lin; Soares, Thereza A.
- Journal of Computational Chemistry, Vol. 35, Issue 19
Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes
journal, January 2014
- Nascimento, Agrinaldo; Pontes, Frederico J. S.; Lins, Roberto D.
- Chem. Commun., Vol. 50, Issue 2
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria
journal, March 2012
- Nikaido, Hiroshi; Pagès, Jean-Marie
- FEMS Microbiology Reviews, Vol. 36, Issue 2
The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
journal, November 2008
- Pagès, Jean-Marie; James, Chloë E.; Winterhalter, Mathias
- Nature Reviews Microbiology, Vol. 6, Issue 12
On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein: Role of TolC in multidrug efflux
journal, January 2013
- Krishnamoorthy, Ganesh; Tikhonova, Elena B.; Dhamdhere, Girija
- Molecular Microbiology, Vol. 87, Issue 5
AcrA suppressor alterations reverse the drug hypersensitivity phenotype of a TolC mutant by inducing TolC aperture opening
journal, March 2010
- Weeks, Jon W.; Celaya-Kolb, Teresa; Pecora, Sara
- Molecular Microbiology, Vol. 75, Issue 6
OmpA Is the Principal Nonspecific Slow Porin of Acinetobacter baumannii
journal, August 2012
- Sugawara, Etsuko; Nikaido, Hiroshi
- Journal of Bacteriology, Vol. 194, Issue 15
Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii
journal, February 2007
- Vila, Jordi; Martí, Sara; Sánchez-Céspedes, Javier
- Journal of Antimicrobial Chemotherapy, Vol. 59, Issue 6
Alternative folding pathways of the major porin OprF of Pseudomonas aeruginosa: Alternative folding pathways
journal, February 2012
- Sugawara, Etsuko; Nagano, Keiji; Nikaido, Hiroshi
- FEBS Journal, Vol. 279, Issue 6
Pseudomonas aeruginosa Porin OprF Exists in Two Different Conformations
journal, June 2006
- Sugawara, Etsuko; Nestorovich, Ekaterina M.; Bezrukov, Sergey M.
- Journal of Biological Chemistry, Vol. 281, Issue 24
Toward Understanding the Outer Membrane Uptake of Small Molecules by Pseudomonas aeruginosa
journal, April 2013
- Eren, Elif; Parkin, Jamie; Adelanwa, Ayodele
- Journal of Biological Chemistry, Vol. 288, Issue 17
Role of the Novel OprD Family of Porins in Nutrient Uptake in Pseudomonas aeruginosa
journal, January 2006
- Tamber, Sandeep; Ochs, Martina M.; Hancock, Robert E. W.
- Journal of Bacteriology, Vol. 188, Issue 1
Structural Basis for Outer Membrane Sugar Uptake in Pseudomonads
journal, November 2012
- van den Berg, Bert
- Journal of Biological Chemistry, Vol. 287, Issue 49
Small-Molecule Transport by CarO, an Abundant Eight-Stranded β-Barrel Outer Membrane Protein from Acinetobacter baumannii
journal, July 2015
- Zahn, Michael; D'Agostino, Tommaso; Eren, Elif
- Journal of Molecular Biology, Vol. 427, Issue 14
Acquisition of Resistance to Carbapenems in Multidrug-Resistant Clinical Strains of Acinetobacter baumannii : Natural Insertional Inactivation of a Gene Encoding a Member of a Novel Family of β-Barrel Outer Membrane Proteins
journal, April 2005
- Mussi, María A.; Limansky, Adriana S.; Viale, Alejandro M.
- Antimicrobial Agents and Chemotherapy, Vol. 49, Issue 4
The Outer Membrane of Acinetobacter: Structure-Function Relationships
book, January 1991
- Borneleit, P.; Kleber, H. -P.
- The Biology of Acinetobacter
Expression and refolding of Omp38 from Burkholderia pseudomallei and Burkholderia thailandensis, and its function as a diffusion porin
journal, December 2004
- Siritapetawee, Jaruwan; Prinz, Heino; Krittanai, Chartchai
- Biochemical Journal, Vol. 384, Issue 3
Molecular analysis of antimicrobial agent translocation through the membrane porin BpsOmp38 from an ultraresistant Burkholderia pseudomallei strain
journal, June 2011
- Suginta, Wipa; Mahendran, Kozhinjampara R.; Chumjan, Watcharin
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1808, Issue 6
Functional reconstitution, gene isolation and topology modelling of porins from Burkholderia pseudomallei and Burkholderia thailandensis
journal, February 2004
- Siritapetawee, Jaruwan; Prinz, Heino; Samosornsuk, Worada
- Biochemical Journal, Vol. 377, Issue 3
Kinetic control of TolC recruitment by multidrug efflux complexes
journal, September 2009
- Tikhonova, E. B.; Dastidar, V.; Rybenkov, V. V.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 38
Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-TolC
journal, April 2011
- Tikhonova, Elena B.; Yamada, Yoichi; Zgurskaya, Helen I.
- Chemistry & Biology, Vol. 18, Issue 4
AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex
journal, July 2004
- Tikhonova, Elena B.; Zgurskaya, Helen I.
- Journal of Biological Chemistry, Vol. 279, Issue 31
Antibiotic efflux mechanisms
journal, January 1999
- Nikaido, Hiroshi; Zgurskaya, Helen I.
- Current Opinion in Infectious Diseases, Vol. 12, Issue 6
A data-driven approach to modeling the tripartite structure of multidrug resistance efflux pumps: Modeling of Multidrug Resistance Efflux Pumps
journal, November 2014
- Phillips, Joshua L.; Gnanakaran, S.
- Proteins: Structure, Function, and Bioinformatics, Vol. 83, Issue 1
Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
journal, June 1999
- Zgurskaya, H. I.; Nikaido, H.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 13
Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump
journal, May 2003
- Yu, E. W.
- Science, Vol. 300, Issue 5621
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
journal, August 2006
- Murakami, Satoshi; Nakashima, Ryosuke; Yamashita, Eiki
- Nature, Vol. 443, Issue 7108
Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations
journal, November 2012
- Vargiu, A. V.; Nikaido, H.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 50
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
journal, November 2011
- Nakashima, Ryosuke; Sakurai, Keisuke; Yamasaki, Seiji
- Nature, Vol. 480, Issue 7378, p. 565-569
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli
journal, March 2009
- Nagano, K.; Nikaido, H.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 14
Multidrug Efflux in Pseudomonas aeruginosa Components, Mechanisms and Clinical Significance
journal, May 2001
- Poole, Keith; Srikumar, Ramakrishnan
- Current Topics in Medicinal Chemistry, Vol. 1, Issue 1
Two Efflux Systems Expressed Simultaneously in Multidrug-Resistant Pseudomonas aeruginosa
journal, October 2000
- Pumbwe, Lilian; Piddock, Laura J. V.
- Antimicrobial Agents and Chemotherapy, Vol. 44, Issue 10
Efflux-mediated multiresistance in Gram-negative bacteria
journal, January 2004
- Poole, K.
- Clinical Microbiology and Infection, Vol. 10, Issue 1
The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication
journal, April 2005
- Aendekerk, Séverine; Diggle, Stephen P.; Song, Zhijun
- Microbiology, Vol. 151, Issue 4
Multidrug Efflux Systems Play an Important Role in the Invasiveness of Pseudomonas aeruginosa
journal, July 2002
- Hirakata, Yoichi; Srikumar, Ramakrishnan; Poole, Keith
- Journal of Experimental Medicine, Vol. 196, Issue 1
Efflux pump-mediated drug resistance in Burkholderia
journal, April 2015
- Podnecky, Nicole L.; Rhodes, Katherine A.; Schweizer, Herbert P.
- Frontiers in Microbiology, Vol. 06
Efflux-Mediated Antibiotic Resistance in Acinetobacter spp
journal, March 2011
- Coyne, Sébastien; Courvalin, Patrice; Périchon, Bruno
- Antimicrobial Agents and Chemotherapy, Vol. 55, Issue 3
Contribution of Resistance-Nodulation-Cell Division Efflux Systems to Antibiotic Resistance and Biofilm Formation in Acinetobacter baumannii
journal, May 2015
- Yoon, Eun-Jeong; Nait Chabane, Yassine; Goussard, Sylvie
- mBio, Vol. 6, Issue 2
Antibiotic Susceptibility Profiles ofEscherichia coli Strains Lacking Multidrug Efflux Pump Genes
journal, April 2001
- Sulavik, Mark C.; Houseweart, Chad; Cramer, Christina
- Antimicrobial Agents and Chemotherapy, Vol. 45, Issue 4
A coordinated network of transporters with overlapping specificities provides a robust survival strategy
journal, May 2009
- Tal, N.; Schuldiner, S.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 22
Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance
journal, June 2000
- Lee, A.; Mao, W.; Warren, M. S.
- Journal of Bacteriology, Vol. 182, Issue 11
Mechanistic Parallels in Bacterial and Human Multidrug Efflux Transporters
journal, October 2002
- Zgurskaya, H. I.; Nikaido, H.
- Current Protein & Peptide Science, Vol. 3, Issue 5
Bacterial multidrug transport through the lens of the major facilitator superfamily
journal, May 2009
- Fluman, Nir; Bibi, Eitan
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1794, Issue 5
EmrE, a model for studying evolution and mechanism of ion-coupled transporters
journal, May 2009
- Schuldiner, Shimon
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1794, Issue 5
Multidrug efflux transporters in the MATE family
journal, May 2009
- Kuroda, Teruo; Tsuchiya, Tomofusa
- Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1794, Issue 5
Prospects for new antibiotics: a molecule-centered perspective
journal, June 2013
- Walsh, Christopher T.; Wencewicz, Timothy A.
- The Journal of Antibiotics, Vol. 67, Issue 1
Polymyxins and their novel derivatives
journal, October 2010
- Vaara, Martti
- Current Opinion in Microbiology, Vol. 13, Issue 5
Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’
journal, March 2014
- Velkov, Tony; Roberts, Kade D.; Nation, Roger L.
- ACS Chemical Biology, Vol. 9, Issue 5
Investigational Antimicrobial Agents of 2013
journal, October 2013
- Pucci, Michael J.; Bush, Karen
- Clinical Microbiology Reviews, Vol. 26, Issue 4
Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa
journal, April 2015
- Isabella, Vincent M.; Campbell, Arthur J.; Manchester, John
- Chemistry & Biology, Vol. 22, Issue 4
Recent insights into iron import by bacteria
journal, April 2011
- Braun, Volkmar; Hantke, Klaus
- Current Opinion in Chemical Biology, Vol. 15, Issue 2
Metallome of P seudomonas aeruginosa : a role for siderophores: Metallome of Pseudomonas aeruginosa
journal, August 2015
- Cunrath, Olivier; Geoffroy, Valérie A.; Schalk, Isabelle J.
- Environmental Microbiology, Vol. 18, Issue 10
Siderophore conjugates: Siderophore conjugates
journal, January 2013
- Page, Malcolm G. P.
- Annals of the New York Academy of Sciences, Vol. 1277, Issue 1
In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli
journal, June 2010
- Page, Malcolm G. P.; Dantier, Clothilde; Desarbre, Eric
- Antimicrobial Agents and Chemotherapy, Vol. 54, Issue 6
Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation.
journal, January 1989
- Chen, Randal H.; Buko, Alexander M.; Whittern, David N.
- The Journal of Antibiotics, Vol. 42, Issue 4
Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. III. Microbiologic profile.
journal, January 1989
- Fernandes, Prabhavathi B.; Swanson, Robert N.; Hardy, Dwight J.
- The Journal of Antibiotics, Vol. 42, Issue 4
Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. I. Taxonomy of the producing organism and fermentation.
journal, January 1989
- Karwowski, J. P.; Jackson, M.; Theriault, R. J.
- The Journal of Antibiotics, Vol. 42, Issue 4
High-Level Pacidamycin Resistance in Pseudomonas aeruginosa Is Mediated by an Opp Oligopeptide Permease Encoded by the opp-fabI Operon
journal, August 2013
- Mistry, Anita; Warren, Mark S.; Cusick, John K.
- Antimicrobial Agents and Chemotherapy, Vol. 57, Issue 11
Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery
journal, May 2008
- O’Shea, Rosemarie; Moser, Heinz E.
- Journal of Medicinal Chemistry, Vol. 51, Issue 10
A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans
journal, May 2010
- Burns, Andrew R.; Wallace, Iain M.; Wildenhain, Jan
- Nature Chemical Biology, Vol. 6, Issue 7
General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria
journal, September 2014
- Davis, Tony D.; Gerry, Christopher J.; Tan, Derek S.
- ACS Chemical Biology, Vol. 9, Issue 11
Thinking Outside the “Bug”: A Unique Assay To Measure Intracellular Drug Penetration in Gram-Negative Bacteria
journal, March 2015
- Zhou, Ying; Joubran, Camil; Miller-Vedam, Lakshmi
- Analytical Chemistry, Vol. 87, Issue 7
Molecular Determinants of AcrB-Mediated Bacterial Efflux Implications for Drug Discovery: Miniperspective
journal, January 2012
- Manchester, John I.; Buurman, Ed T.; Bisacchi, Gregory S.
- Journal of Medicinal Chemistry, Vol. 55, Issue 6
Molecular Simulations of Gram-Negative Bacterial Membranes: A Vignette of Some Recent Successes
journal, August 2015
- Parkin, Jamie; Chavent, Matthieu; Khalid, Syma
- Biophysical Journal, Vol. 109, Issue 3
Interaction of the Antimicrobial Peptide Polymyxin B1 with Both Membranes of E. coli: A Molecular Dynamics Study
journal, April 2015
- Berglund, Nils A.; Piggot, Thomas J.; Jefferies, Damien
- PLOS Computational Biology, Vol. 11, Issue 4
Selected Arylpiperazines Are Capable of Reversing Multidrug Resistance in Escherichia coli Overexpressing RND Efflux Pumps
journal, February 2005
- Bohnert, Jürgen A.; Kern, Winfried V.
- Antimicrobial Agents and Chemotherapy, Vol. 49, Issue 2
Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa
journal, August 2003
- Renau, Thomas E.; Léger, Roger; Filonova, Lubov
- Bioorganic & Medicinal Chemistry Letters, Vol. 13, Issue 16
The relationship between physicochemical properties, In vitro activity and pharmacokinetic profiles of analogues of diamine-Containing efflux pump inhibitors
journal, December 2003
- Watkins, William J.; Landaverry, Yakira; Léger, Roger
- Bioorganic & Medicinal Chemistry Letters, Vol. 13, Issue 23
Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy
journal, January 2001
- Lomovskaya, Olga; Warren, Mark S.; Lee, Angela
- Antimicrobial Agents and Chemotherapy, Vol. 45, Issue 1
Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization
journal, May 2007
- Watkins, William J.; Chong, Lee; Cho, Aesop
- Bioorganic & Medicinal Chemistry Letters, Vol. 17, Issue 10
3-Arylpiperidines as potentiators of existing antibacterial agents
journal, July 2001
- Thorarensen, Atli; Presley-Bodnar, Alice L.; Marotti, Keith R.
- Bioorganic & Medicinal Chemistry Letters, Vol. 11, Issue 14
Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli
journal, November 2013
- Opperman, Timothy J.; Kwasny, Steven M.; Kim, Hong-Suk
- Antimicrobial Agents and Chemotherapy, Vol. 58, Issue 2
MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization
journal, December 2003
- Nakayama, Kiyoshi; Ishida, Yohei; Ohtsuka, Masami
- Bioorganic & Medicinal Chemistry Letters, Vol. 13, Issue 23
Structural basis for the inhibition of bacterial multidrug exporters
journal, June 2013
- Nakashima, Ryosuke; Sakurai, Keisuke; Yamasaki, Seiji
- Nature, Vol. 500, Issue 7460, p. 102-106
Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa
journal, June 1999
- Lomovskaya, Olga; Lee, Angela; Hoshino, Kazuki
- Antimicrobial Agents and Chemotherapy, Vol. 43, Issue 6
Structure of the AcrAB–TolC multidrug efflux pump
journal, April 2014
- Du, Dijun; Wang, Zhao; James, Nathan R.
- Nature, Vol. 509, Issue 7501
Works referencing / citing this record:
Development of a nebramine-cyclam conjugate as an antibacterial adjuvant to potentiate β-lactam antibiotics against multidrug-resistant P. aeruginosa
journal, August 2019
- Ammeter, Derek; Idowu, Temilolu; Zhanel, George G.
- The Journal of Antibiotics, Vol. 72, Issue 11
Structure-function analysis of the Escherichia coli β–barrel assembly enhancing protease BepA suggests a role for a self-inhibitory state
posted_content, July 2019
- Bryant, Jack A.; Cadby, Ian T.; Chong, Zhi-Soon
- BioRxiv
Bifurcation kinetics of drug uptake by Gram-negative bacteria
journal, September 2017
- Westfall, David A.; Krishnamoorthy, Ganesh; Wolloscheck, David
- PLOS ONE, Vol. 12, Issue 9
Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux
journal, January 2019
- Stone, M. Rhia L.; Masi, Muriel; Phetsang, Wanida
- MedChemComm, Vol. 10, Issue 6
Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm
journal, December 2018
- Dumont, Estelle; Vergalli, Julia; Pajovic, Jelena
- Life Science Alliance, Vol. 2, Issue 1
Polybasic peptide–levofloxacin conjugates potentiate fluoroquinolones and other classes of antibiotics against multidrug-resistant Gram-negative bacteria
journal, January 2019
- Berry, Liam; Domalaon, Ronald; Brizuela, Marc
- MedChemComm, Vol. 10, Issue 4
Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria
journal, January 2019
- Nasim, Muhammad Jawad; Witek, Karolina; Kincses, Annamária
- New Journal of Chemistry, Vol. 43, Issue 15
Ironing out pyoverdine’s chromophore structure: serendipity or design?
journal, June 2019
- Cézard, Christine; Sonnet, Pascal; Bouvier, Benjamin
- JBIC Journal of Biological Inorganic Chemistry, Vol. 24, Issue 5
Genome-wide discovery of epistatic loci affecting antibiotic resistance using evolutionary couplings
journal, June 2018
- Schubert, Benjamin; Maddamsetti, Rohan; Nyman, Jackson
- Nature Microbiology
Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria
journal, January 2019
- Patel, Pooja; Joshi, Chinmayi; Kothari, Vijay
- Advances in Pharmacological Sciences, Vol. 2019
Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria
journal, December 2019
- Vergalli, Julia; Bodrenko, Igor V.; Masi, Muriel
- Nature Reviews Microbiology, Vol. 18, Issue 3
Increasing the permeability of Escherichia coli using MAC13243
journal, December 2017
- Muheim, Claudio; Götzke, Hansjörg; Eriksson, Anna U.
- Scientific Reports, Vol. 7, Issue 1
The Concept of an Ideal Antibiotic: Implications for Drug Design
journal, March 2019
- Gajdács, Márió
- Molecules, Vol. 24, Issue 5
Can Biofilm Be Reversed Through Quorum Sensing in Pseudomonas aeruginosa?
journal, July 2019
- Yan, Shaomin; Wu, Guang
- Frontiers in Microbiology, Vol. 10
Spectrofluorimetric quantification of antibiotic drug concentration in bacterial cells for the characterization of translocation across bacterial membranes
journal, May 2018
- Vergalli, Julia; Dumont, Estelle; Pajović, Jelena
- Nature Protocols, Vol. 13, Issue 6
Antimicrobial activity of trans -cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates
journal, October 2018
- Yilmaz, S.; Sova, M.; Ergün, S.
- Journal of Applied Microbiology, Vol. 125, Issue 6
Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis
journal, January 2018
- Cloutier, Maude; Muru, Kevin; Ravicoularamin, Gokulakrishnan
- Natural Product Reports, Vol. 35, Issue 12
Mechanistic insight into the effect of BT‐benzo‐29 on the Z‐ring in Bacillus subtilis
journal, May 2020
- Kunal, Kishore; Tiwari, Rishu; Dhaked, Hemendra P. S.
- IUBMB Life, Vol. 72, Issue 5
Towards the Evolution of Artificial Metalloenzymes—A Protein Engineer's Perspective
journal, February 2019
- Markel, Ulrich; Sauer, Daniel F.; Schiffels, Johannes
- Angewandte Chemie International Edition, Vol. 58, Issue 14
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice
journal, August 2019
- Mourtada, Rida; Herce, Henry D.; Yin, Daniel J.
- Nature Biotechnology, Vol. 37, Issue 10
The cyclic peptide labaditin does not alter the outer membrane integrity of Salmonella enterica serovar Typhimurium
journal, February 2019
- Barbosa, Simone C.; Nobre, Thatyane M.; Volpati, Diogo
- Scientific Reports, Vol. 9, Issue 1
A simple phenotypic test for detecting the contribution of outer membrane permeability to carbapenem resistance
journal, January 2020
- Pinet, Elizabeth; Franceschi, Christine; Collin, Valérie
- Journal of Medical Microbiology, Vol. 69, Issue 1
Gram-negative synergy and mechanism of action of alkynyl bisbenzimidazoles
journal, October 2019
- Chamberlin, Jordan; Story, Sandra; Ranjan, Nihar
- Scientific Reports, Vol. 9, Issue 1
The characteristics of antibiotic resistance and phenotypes in 29 outer‐membrane protein mutant strains in Aeromonas hydrophila
journal, August 2019
- Li, Zeqi; Wang, Yuqian; Li, Xiaoyan
- Environmental Microbiology, Vol. 21, Issue 12
Sideromycins as Pathogen-Targeted Antibiotics
book, January 2017
- Wencewicz, Timothy A.; Miller, Marvin J.
- Topics in Medicinal Chemistry
Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens
journal, April 2019
- Bhagirath, Anjali Y.; Li, Yanqi; Patidar, Rakesh
- International Journal of Molecular Sciences, Vol. 20, Issue 7
Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria
journal, February 2017
- Masi, Muriel; Réfregiers, Matthieu; Pos, Klaas M.
- Nature Microbiology, Vol. 2, Issue 3
A Small-Molecule Inhibitor of trans -Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus
journal, January 2019
- Huang, Yueyang; Alumasa, John N.; Callaghan, Lauren T.
- Antimicrobial Agents and Chemotherapy, Vol. 63, Issue 4
Siderophore–Antibiotic Conjugate Design: New Drugs for Bad Bugs?
journal, September 2019
- Negash, Kokob H.; Norris, James K. S.; Hodgkinson, James T.
- Molecules, Vol. 24, Issue 18, p. 3314
Auf dem Weg zur Evolution artifizieller Metalloenzyme – aus einem Protein‐Engineering‐Blickwinkel
journal, February 2019
- Markel, Ulrich; Sauer, Daniel F.; Schiffels, Johannes
- Angewandte Chemie, Vol. 131, Issue 14
Synthetic ionophores as non-resistant antibiotic adjuvants
journal, January 2019
- Patel, Mohit B.; Garrad, Evan; Meisel, Joseph W.
- RSC Advances, Vol. 9, Issue 4
Bactericidal Properties of Plants-Derived Metal and Metal Oxide Nanoparticles (NPs)
journal, June 2018
- Teow, Sin-Yeang; Wong, Magdelyn; Yap, Hooi-Yeen
- Molecules, Vol. 23, Issue 6
De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa
journal, January 2019
- Zhang, Jian; Zhao, Tianhu; Yang, Rongwen
- Chemical Science, Vol. 10, Issue 27
Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA
journal, August 2018
- Alexander, Mary Kate; Miu, Anh; Oh, Angela
- Antimicrobial Agents and Chemotherapy, Vol. 62, Issue 11
Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?
journal, March 2018
- Domalaon, Ronald; Idowu, Temilolu; Zhanel, George G.
- Clinical Microbiology Reviews, Vol. 31, Issue 2
TonB-Dependent Transporters in Sphingomonads: Unraveling Their Distribution and Function in Environmental Adaptation
journal, March 2020
- Samantarrai, Devyani; Lakshman Sagar, Annapoorni; Gudla, Ramurthy
- Microorganisms, Vol. 8, Issue 3
Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome
journal, July 2018
- Helfrich, Eric J. N.; Vogel, Christine M.; Ueoka, Reiko
- Nature Microbiology, Vol. 3, Issue 8
Perspective on Antibacterial Lead Identification Challenges and the Role of Hypothesis-Driven Strategies
journal, March 2019
- McDowell, Laura L.; Quinn, Cheryl L.; Leeds, Jennifer A.
- SLAS DISCOVERY: Advancing the Science of Drug Discovery, Vol. 24, Issue 4
Outer Membrane Porins
book, January 2019
- Masi, Muriel; Winterhalter, Mathias; Pagès, Jean-Marie
- Subcellular Biochemistry
Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance
journal, July 2019
- Davin-Regli, Anne; Lavigne, Jean-Philippe; Pagès, Jean-Marie
- Clinical Microbiology Reviews, Vol. 32, Issue 4
Overcoming problems of poor drug penetration into bacteria: challenges and strategies for medicinal chemists
journal, March 2018
- Benedetto Tiz, Davide; Kikelj, Danijel; Zidar, Nace
- Expert Opinion on Drug Discovery, Vol. 13, Issue 6
The outer membrane is an essential load-bearing element in Gram-negative bacteria
journal, July 2018
- Rojas, Enrique R.; Billings, Gabriel; Odermatt, Pascal D.
- Nature, Vol. 559, Issue 7715
Nitro sulfonyl fluorides are a new pharmacophore for the development of antibiotics
journal, January 2018
- Sadlowski, Corinne; Park, Bora; Araujo Borges, Clarissa
- Molecular Systems Design & Engineering, Vol. 3, Issue 4
Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells
journal, October 2017
- Brunati, Cristina; Thomsen, Thomas T.; Gaspari, Eleonora
- Journal of Antimicrobial Chemotherapy, Vol. 73, Issue 2
Bifunctional antimicrobial conjugates and hybrid antimicrobials
journal, January 2017
- Klahn, P.; Brönstrup, M.
- Natural Product Reports, Vol. 34, Issue 7
Antimicrobial Activity of Several Cineole-Rich Western Australian Eucalyptus Essential Oils
journal, December 2018
- Aldoghaim, Fahad; Flematti, Gavin; Hammer, Katherine
- Microorganisms, Vol. 6, Issue 4
The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics: Challenges in developing broad-spectrum antibiotics
journal, February 2018
- Richter, Michelle F.; Hergenrother, Paul J.
- Annals of the New York Academy of Sciences, Vol. 1435, Issue 1
Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance
journal, December 2018
- Shriram, Varsha; Khare, Tushar; Bhagwat, Rohit
- Frontiers in Microbiology, Vol. 9
Reversing resistance to counter antimicrobial resistance in the World Health Organisation’s critical priority of most dangerous pathogens
journal, April 2019
- Venter, Henrietta
- Bioscience Reports, Vol. 39, Issue 4
Enhancing uptake of antibiotics into Gram-negative bacteria using nonribosome-targeting aminoglycoside-based adjuvants
journal, July 2019
- Schweizer, Frank
- Future Medicinal Chemistry, Vol. 11, Issue 13
Type 9 secretion system structures reveal a new protein transport mechanism
journal, November 2018
- Lauber, Frédéric; Deme, Justin C.; Lea, Susan M.
- Nature, Vol. 564, Issue 7734
Antibacterial and potentiation properties of charge-optimized polyrotaxanes for combating opportunistic bacteria
journal, January 2018
- Qiao, Jing; Liu, Zhi; Purro, Max
- Journal of Materials Chemistry B, Vol. 6, Issue 33
Surfactant-enhanced DNA accessibility to nuclease accelerates phenotypic β-lactam antibiotic susceptibility testing of Neisseria gonorrhoeae
journal, March 2020
- Savela, Emily S.; Schoepp, Nathan G.; Cooper, Matthew M.
- PLOS Biology, Vol. 18, Issue 3
Better living through chemistry: Addressing emerging antibiotic resistance
journal, February 2018
- Coussens, Nathan P.; Molinaro, Ashley L.; Culbertson, Kayla J.
- Experimental Biology and Medicine, Vol. 243, Issue 6
Microbiology: Peeling Back the Layers of Bacterial Envelope Mechanics
journal, October 2018
- Shaevitz, Joshua W.
- Current Biology, Vol. 28, Issue 20
Direct visualization of a molecular handshake that governs kin recognition and tissue formation in myxobacteria
journal, July 2019
- Cao, Pengbo; Wall, Daniel
- Nature Communications, Vol. 10, Issue 1
Fluoroquinolone structure and translocation flux across bacterial membrane
journal, August 2017
- Vergalli, Julia; Dumont, Estelle; Cinquin, Bertrand
- Scientific Reports, Vol. 7, Issue 1
A cAMP/CRP-controlled mechanism for the incorporation of extracellular ADP-glucose in Escherichia coli involving NupC and NupG nucleoside transporters
journal, October 2018
- Almagro, Goizeder; Viale, Alejandro M.; Montero, Manuel
- Scientific Reports, Vol. 8, Issue 1
The cyclic peptide labaditin does not alter the outer membrane integrity of Salmonella enterica serovar Typhimurium
journal, February 2019
- Barbosa, Simone C.; Nobre, Thatyane M.; Volpati, Diogo
- Scientific Reports, Vol. 9, Issue 1
Functional characterization of a putative DNA methyltransferase, EadM, in Xanthomonas axonopodis pv. glycines by proteomic and phenotypic analyses
journal, February 2019
- Park, Hye-Jee; Jung, Boknam; Lee, Jungkwan
- Scientific Reports, Vol. 9, Issue 1
Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells
journal, October 2017
- Brunati, Cristina; Thomsen, Thomas T.; Gaspari, Eleonora
- Journal of Antimicrobial Chemotherapy, Vol. 73, Issue 2
Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-β-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance
journal, April 2020
- Wachino, Jun-ichi; Jin, Wanchun; Kimura, Kouji
- mBio, Vol. 11, Issue 2
Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria
journal, January 2019
- Patel, Pooja; Joshi, Chinmayi; Kothari, Vijay
- Advances in Pharmacological Sciences, Vol. 2019
Better living through chemistry: Addressing emerging antibiotic resistance
journal, February 2018
- Coussens, Nathan P.; Molinaro, Ashley L.; Culbertson, Kayla J.
- Experimental Biology and Medicine, Vol. 243, Issue 6
Surfactant-enhanced DNA accessibility to nuclease accelerates phenotypic β-lactam antibiotic susceptibility testing of Neisseria gonorrhoeae
journal, March 2020
- Savela, Emily S.; Schoepp, Nathan G.; Cooper, Matthew M.
- PLOS Biology, Vol. 18, Issue 3
Polydim-I antimicrobial activity against MDR bacteria and its model membrane interaction
journal, June 2017
- Rangel, Marisa; Castro, Fabíola Fernandes dos Santos; Mota-Lima, Lilian Daiene
- PLOS ONE, Vol. 12, Issue 6
Bifurcation kinetics of drug uptake by Gram-negative bacteria
journal, September 2017
- Westfall, David A.; Krishnamoorthy, Ganesh; Wolloscheck, David
- PLOS ONE, Vol. 12, Issue 9
Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm
journal, December 2018
- Dumont, Estelle; Vergalli, Julia; Pajovic, Jelena
- Life Science Alliance, Vol. 2, Issue 1
E. coli Group 1 Capsular Polysaccharide Exportation Nanomachinary as a Plausible Antivirulence Target in the Perspective of Emerging Antimicrobial Resistance
journal, January 2017
- Sachdeva, Shivangi; Palur, Raghuvamsi V.; Sudhakar, Karpagam U.
- Frontiers in Microbiology, Vol. 8
Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance
journal, December 2018
- Shriram, Varsha; Khare, Tushar; Bhagwat, Rohit
- Frontiers in Microbiology, Vol. 9
In vitro Antimicrobial Activity of Robenidine, Ethylenediaminetetraacetic Acid and Polymyxin B Nonapeptide Against Important Human and Veterinary Pathogens
journal, April 2019
- Khazandi, Manouchehr; Pi, Hongfei; Chan, Wei Yee
- Frontiers in Microbiology, Vol. 10
Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens
journal, April 2019
- Bhagirath, Anjali Y.; Li, Yanqi; Patidar, Rakesh
- International Journal of Molecular Sciences, Vol. 20, Issue 7
Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones
journal, October 2017
- Polaquini, Carlos; Torrezan, Guilherme; Santos, Vanessa
- Molecules, Vol. 22, Issue 10
Bactericidal Properties of Plants-Derived Metal and Metal Oxide Nanoparticles (NPs)
journal, June 2018
- Teow, Sin-Yeang; Wong, Magdelyn; Yap, Hooi-Yeen
- Molecules, Vol. 23, Issue 6
The Concept of an Ideal Antibiotic: Implications for Drug Design
journal, March 2019
- Gajdács, Márió
- Molecules, Vol. 24, Issue 5
Siderophore–Antibiotic Conjugate Design: New Drugs for Bad Bugs?
journal, September 2019
- Negash, Kokob H.; Norris, James K. S.; Hodgkinson, James T.
- Molecules, Vol. 24, Issue 18, p. 3314