Genomic Perspectives of Transcriptional Regulation in Forebrain Development

Nord, Alex S.; Pattabiraman, Kartik; Visel, Axel; Rubenstein, John L. R.

doi:10.1016/j.neuron.2014.11.011

Title: Genomic Perspectives of Transcriptional Regulation in Forebrain Development

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Abstract

The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric disorders are due to genetic defects affecting forebrain development, making it imperative to understand the underlying genetic circuitry. We report that recent progress now makes it possible to begin fully elucidating the genomic regulatory mechanisms that control forebrain gene expression. Here, we discuss the current knowledge of how transcription factors drive gene expression programs through their interactions with cis-acting genomic elements, such as enhancers; how analyses of chromatin and DNA modifications provide insights into gene expression states; and how these approaches yield insights into the evolution of the human brain.

Authors:: Nord, Alex S.; Pattabiraman, Kartik; Visel, Axel; Rubenstein, John L. R.

Publication Date:: Thu Jan 01 00:00:00 EST 2015

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1234146

Alternate Identifier(s):: OSTI ID: 1257835

Grant/Contract Number:: AC02-05CH11231; GM105202; R01NS062859A; R01HG003988; R01NS34661; R01MH081880; R37MH049428; T32 GMO7618

Resource Type:: Published Article

Journal Name:: Neuron

Additional Journal Information:: Journal Name: Neuron Journal Volume: 85 Journal Issue: 1; Journal ID: ISSN 0896-6273

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

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                    Nord, Alex S., Pattabiraman, Kartik, Visel, Axel, and Rubenstein, John L. R. Genomic Perspectives of Transcriptional Regulation in Forebrain Development.  United States: N. p., 2015. 
Web.  doi:10.1016/j.neuron.2014.11.011.

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                    Nord, Alex S., Pattabiraman, Kartik, Visel, Axel, & Rubenstein, John L. R. Genomic Perspectives of Transcriptional Regulation in Forebrain Development.  United States.  https://doi.org/10.1016/j.neuron.2014.11.011

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                    Nord, Alex S., Pattabiraman, Kartik, Visel, Axel, and Rubenstein, John L. R. Thu .  
"Genomic Perspectives of Transcriptional Regulation in Forebrain Development".  United States.  https://doi.org/10.1016/j.neuron.2014.11.011.

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@article{osti_1234146,

  title        = {Genomic Perspectives of Transcriptional Regulation in Forebrain Development},

  author       = {Nord, Alex S. and Pattabiraman, Kartik and Visel, Axel and Rubenstein, John L. R.},

  abstractNote = {The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric disorders are due to genetic defects affecting forebrain development, making it imperative to understand the underlying genetic circuitry. We report that recent progress now makes it possible to begin fully elucidating the genomic regulatory mechanisms that control forebrain gene expression. Here, we discuss the current knowledge of how transcription factors drive gene expression programs through their interactions with cis-acting genomic elements, such as enhancers; how analyses of chromatin and DNA modifications provide insights into gene expression states; and how these approaches yield insights into the evolution of the human brain.},

  doi          = {10.1016/j.neuron.2014.11.011},

  journal      = {Neuron},

  number       = 1,

  volume       = 85,

  place        = {United States},

  year         = {Thu Jan 01 00:00:00 EST 2015},

  month        = {Thu Jan 01 00:00:00 EST 2015}

}

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