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Title: Genome-Scale Metabolic Reconstructions and Theoretical Investigation of Methane Conversion in Methylomicrobium buryatense Strain 5G(B1)

Methane-utilizing bacteria (methanotrophs) are capable of growth on methane and are attractive systems for bio-catalysis. However, the application of natural methanotrophic strains to large-scale production of value-added chemicals/biofuels requires a number of physiological and genetic alterations. An accurate metabolic model coupled with flux balance analysis can provide a solid interpretative framework for experimental data analyses and integration.
Authors:
 [1] ;  [1] ;  [2] ;  [3] ;  [2] ;  [3] ;  [2] ;  [1]
  1. San Diego State Univ., CA (United States)
  2. Univ. of Washington, Seattle, WA (United States)
  3. National Renewable Energy Lab. (NREL), Golden, CO (United States)
Publication Date:
OSTI Identifier:
1233694
Report Number(s):
NREL/JA--5100-65604
Journal ID: ISSN 1475-2859
Grant/Contract Number:
AC36-08GO28308
Type:
Accepted Manuscript
Journal Name:
Microbial Cell Factories
Additional Journal Information:
Journal Volume: 14; Journal Issue: 188; Related Information: Microbial Cell Factories; Journal ID: ISSN 1475-2859
Publisher:
BioMed Central
Research Org:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org:
USDOE Office of Energy Efficiency and Renewable Energy (EERE)
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; 59 BASIC BIOLOGICAL SCIENCES methane metabolism; flux balance model; Methylomicrobium buryatense; strains 5G and 5G(B1); metabolic engineering of methane utilization