Some thermodynamical aspects of protein hydration water

Mallamace, Francesco; Corsaro, Carmelo; Mallamace, Domenico; Vasi, Sebastiano; Vasi, Cirino; Stanley, H. Eugene; Chen, Sow-Hsin

doi:10.1063/1.4921897

Title: Some thermodynamical aspects of protein hydration water

Authors:

Mallamace, Francesco ^[1]; Corsaro, Carmelo ^[2]; Mallamace, Domenico ^[3];

^[4]; Vasi, Cirino ^[5]; Stanley, H. Eugene ^[6]; Chen, Sow-Hsin ^[7]

Dipartimento di Fisica e Scienze della Terra, Università di Messina and CNISM, I-98168 Messina, Italy, Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA, Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215, USA
Dipartimento di Fisica e Scienze della Terra, Università di Messina and CNISM, I-98168 Messina, Italy, CNR-IPCF, Viale F. Stagno D’Alcontres 37, I-98158 Messina, Italy
Dipartimento SASTAS, Università di Messina, I-98166 Messina, Italy
Dipartimento di Fisica e Scienze della Terra, Università di Messina and CNISM, I-98168 Messina, Italy
CNR-IPCF, Viale F. Stagno D’Alcontres 37, I-98158 Messina, Italy
Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215, USA
Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

Publication Date:: Sun Jun 07 00:00:00 EDT 2015

Sponsoring Org.:: USDOE

OSTI Identifier:: 1228620

Grant/Contract Number:: FG02-90ER45429

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Journal of Chemical Physics

Additional Journal Information:: Journal Name: Journal of Chemical Physics Journal Volume: 142 Journal Issue: 21; Journal ID: ISSN 0021-9606

Publisher:: American Institute of Physics

Country of Publication:: United States

Language:: English

Citation Formats


                    Mallamace, Francesco, Corsaro, Carmelo, Mallamace, Domenico, Vasi, Sebastiano, Vasi, Cirino, Stanley, H. Eugene, and Chen, Sow-Hsin. Some thermodynamical aspects of protein hydration water.  United States: N. p., 2015. 
Web.  doi:10.1063/1.4921897.

Copy to clipboard


                    Mallamace, Francesco, Corsaro, Carmelo, Mallamace, Domenico, Vasi, Sebastiano, Vasi, Cirino, Stanley, H. Eugene, & Chen, Sow-Hsin. Some thermodynamical aspects of protein hydration water.  United States.  https://doi.org/10.1063/1.4921897

Copy to clipboard


                    Mallamace, Francesco, Corsaro, Carmelo, Mallamace, Domenico, Vasi, Sebastiano, Vasi, Cirino, Stanley, H. Eugene, and Chen, Sow-Hsin. Sun .  
"Some thermodynamical aspects of protein hydration water".  United States.  https://doi.org/10.1063/1.4921897.

Copy to clipboard


                    
@article{osti_1228620,

  title        = {Some thermodynamical aspects of protein hydration water},

  author       = {Mallamace, Francesco and Corsaro, Carmelo and Mallamace, Domenico and Vasi, Sebastiano and Vasi, Cirino and Stanley, H. Eugene and Chen, Sow-Hsin},

  abstractNote = {},

  doi          = {10.1063/1.4921897},

  journal      = {Journal of Chemical Physics},

  number       = 21,

  volume       = 142,

  place        = {United States},

  year         = {Sun Jun 07 00:00:00 EDT 2015},

  month        = {Sun Jun 07 00:00:00 EDT 2015}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1063/1.4921897

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 21 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Conductivity in Hydrated Proteins: No Signs of the Fragile-to-Strong Crossover
journal, March 2008

Pawlus, S.; Khodadadi, S.; Sokolov, A. P.
Physical Review Letters, Vol. 100, Issue 10
DOI: 10.1103/PhysRevLett.100.108103

Characterizing the secondary hydration shell on hydrated myoglobin, hemoglobin, and lysozyme powders by its vitrification behavior on cooling and its calorimetric glass-->liquid transition and crystallization behavior on reheating
journal, December 1995

Sartor, G.; Hallbrucker, A.; Mayer, E.
Biophysical Journal, Vol. 69, Issue 6
DOI: 10.1016/S0006-3495(95)80139-6

Glassy behavior of a protein
journal, April 1989

Iben, I. E. T.; Braunstein, D.; Doster, W.
Physical Review Letters, Vol. 62, Issue 16
DOI: 10.1103/PhysRevLett.62.1916

Thermodynamic determination of fragility in liquids and a fragile-to-strong liquid transition in water
journal, April 1999

Ito, Kaori; Moynihan, Cornelius T.; Angell, C. Austen
Nature, Vol. 398, Issue 6727
DOI: 10.1038/19042

Specific heat of hydrated lysozyme, water's contribution to its dynamics, and criteria for glass formation of biomaterials
journal, September 2013

Tombari, Elpidio; Johari, G. P.
The Journal of Chemical Physics, Vol. 139, Issue 10
DOI: 10.1063/1.4819791

Evidence of the existence of the low-density liquid phase in supercooled, confined water
journal, December 2006

Mallamace, F.; Broccio, M.; Corsaro, C.
Proceedings of the National Academy of Sciences, Vol. 104, Issue 2
DOI: 10.1073/pnas.0607138104

Relaxation Processes in Supercooled Confined Water and Implications for Protein Dynamics
journal, June 2006

Swenson, Jan; Jansson, Helén; Bergman, Rikard
Physical Review Letters, Vol. 96, Issue 24
DOI: 10.1103/PhysRevLett.96.247802

Observation of a dynamic crossover in RNA hydration water which triggers a dynamic transition in the biopolymer
journal, January 2008

Chu, Xiang-qiang; Fratini, Emiliano; Baglioni, Piero
Physical Review E, Vol. 77, Issue 1
DOI: 10.1103/PhysRevE.77.011908

The violation of the Stokes-Einstein relation in supercooled water
journal, August 2006

Chen, S. -H.; Mallamace, F.; Mou, C. -Y.
Proceedings of the National Academy of Sciences, Vol. 103, Issue 35
DOI: 10.1073/pnas.0603253103

The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain
journal, April 1951

Pauling, L.; Corey, R. B.; Branson, H. R.
Proceedings of the National Academy of Sciences, Vol. 37, Issue 4, p. 205-211
DOI: 10.1073/pnas.37.4.205

Transport properties of glass-forming liquids suggest that dynamic crossover temperature is as important as the glass transition temperature
journal, December 2010

Mallamace, F.; Branca, C.; Corsaro, C.
Proceedings of the National Academy of Sciences, Vol. 107, Issue 52
DOI: 10.1073/pnas.1015340107

The role of the dynamic crossover temperature and the arrest in glass-forming fluids
journal, September 2011

Mallamace, F.; Corsaro, C.; Stanley, H. E.
The European Physical Journal E, Vol. 34, Issue 9
DOI: 10.1140/epje/i2011-11094-7

Self-Diffusion of Supercooled Water to 238 K Using PGSE NMR Diffusion Measurements
journal, January 1999

Price, William S.; Ide, Hiroyuki; Arata, Yoji
The Journal of Physical Chemistry A, Vol. 103, Issue 4
DOI: 10.1021/jp9839044

Observation of high-temperature dynamic crossover in protein hydration water and its relation to reversible denaturation of lysozyme
journal, April 2009

Zhang, Yang; Lagi, Marco; Liu, Dazhi
The Journal of Chemical Physics, Vol. 130, Issue 13
DOI: 10.1063/1.3081137

Thermodynamic properties of bulk and confined water
journal, November 2014

Mallamace, Francesco; Corsaro, Carmelo; Mallamace, Domenico
The Journal of Chemical Physics, Vol. 141, Issue 18
DOI: 10.1063/1.4895548

How Soft Is a Protein? A Protein Dynamics Force Constant Measured by Neutron Scattering
journal, June 2000

Zaccai, G.
Science, Vol. 288, Issue 5471
DOI: 10.1126/science.288.5471.1604

Thermal motions and function of bacteriorhodopsin in purple membranes: effects of temperature and hydration studied by neutron scattering.
journal, October 1993

Ferrand, M.; Dianoux, A. J.; Petry, W.
Proceedings of the National Academy of Sciences, Vol. 90, Issue 20
DOI: 10.1073/pnas.90.20.9668

Role of Protein-Water Hydrogen Bond Dynamics in the Protein Dynamical Transition
journal, March 2002

Tarek, M.; Tobias, D. J.
Physical Review Letters, Vol. 88, Issue 13
DOI: 10.1103/PhysRevLett.88.138101

Appearance of a fractional Stokes–Einstein relation in water and a structural interpretation of its onset
journal, July 2009

Xu, Limei; Mallamace, Francesco; Yan, Zhenyu
Nature Physics, Vol. 5, Issue 8
DOI: 10.1038/nphys1328

Solvent dependence of dynamic transitions in protein solutions
journal, August 2000

Reat, V.; Dunn, R.; Ferrand, M.
Proceedings of the National Academy of Sciences, Vol. 97, Issue 18
DOI: 10.1073/pnas.97.18.9961

Cooperative charge fluctuations by migrating protons in globular proteins
journal, November 1998

Careri, Giorgio
Progress in Biophysics and Molecular Biology, Vol. 70, Issue 3
DOI: 10.1016/S0079-6107(98)00030-3

Physical Origin of Anharmonic Dynamics in Proteins: New Insights From Resolution-Dependent Neutron Scattering on Homomeric Polypeptides
journal, September 2012

Schiró, Giorgio; Natali, Francesca; Cupane, Antonio
Physical Review Letters, Vol. 109, Issue 12
DOI: 10.1103/PhysRevLett.109.128102

The Low-Temperature Dynamic Crossover Phenomenon in Protein Hydration Water: Simulations vs Experiments
journal, February 2008

Lagi, Marco; Chu, Xiangqiang; Kim, Chansoo
The Journal of Physical Chemistry B, Vol. 112, Issue 6
DOI: 10.1021/jp710714j

Nanosecond Relaxation Dynamics of Hydrated Proteins: Water versus Protein Contributions
journal, May 2011

Khodadadi, S.; Curtis, J. E.; Sokolov, A. P.
The Journal of Physical Chemistry B, Vol. 115, Issue 19
DOI: 10.1021/jp1122213

Role of the solvent in the dynamical transitions of proteins: The case of the lysozyme-water system
journal, July 2007

Mallamace, Francesco; Chen, Sow-Hsin; Broccio, Matteo
The Journal of Chemical Physics, Vol. 127, Issue 4
DOI: 10.1063/1.2757171

Behind the folding funnel diagram
journal, June 2011

Karplus, Martin
Nature Chemical Biology, Vol. 7, Issue 7
DOI: 10.1038/nchembio.565

Hydration-dependent dynamic crossover phenomenon in protein hydration water
journal, October 2014

Wang, Zhe; Fratini, Emiliano; Li, Mingda
Physical Review E, Vol. 90, Issue 4
DOI: 10.1103/PhysRevE.90.042705

A singular thermodynamically consistent temperature at the origin of the anomalous behavior of liquid water
journal, December 2012

Mallamace, Francesco; Corsaro, Carmelo; Stanley, H. Eugene
Scientific Reports, Vol. 2, Issue 1
DOI: 10.1038/srep00993

Calorimetric studies of the kinetic unfreezing of molecular motions in hydrated lysozyme, hemoglobin, and myoglobin
journal, January 1994

Sartor, G.; Mayer, E.; Johari, G. P.
Biophysical Journal, Vol. 66, Issue 1
DOI: 10.1016/S0006-3495(94)80774-X

Water Mediation in Protein Folding and Molecular Recognition
journal, June 2006

Levy, Yaakov; Onuchic, José N.
Annual Review of Biophysics and Biomolecular Structure, Vol. 35, Issue 1
DOI: 10.1146/annurev.biophys.35.040405.102134

Origins of Apparent Fragile-to-Strong Transitions of Protein Hydration Waters
journal, November 2008

Vogel, M.
Physical Review Letters, Vol. 101, Issue 22
DOI: 10.1103/PhysRevLett.101.225701

The protein glass transition as measured by dielectric spectroscopy and differential scanning calorimetry
journal, January 2010

Jansson, H.; Swenson, J.
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1804, Issue 1
DOI: 10.1016/j.bbapap.2009.06.026

Hydration dependence of myoglobin dynamics studied with elastic neutron scattering, differential scanning calorimetry and broadband dielectric spectroscopy
journal, January 2014

Fomina, Margarita; Schirò, Giorgio; Cupane, Antonio
Biophysical Chemistry, Vol. 185
DOI: 10.1016/j.bpc.2013.11.004

A consistent picture of protein dynamics.
journal, November 1984

Parak, F.; Knapp, E. W.
Proceedings of the National Academy of Sciences, Vol. 81, Issue 22
DOI: 10.1073/pnas.81.22.7088

Liquid polymorphism: water in nanoconfined and biological environments
journal, June 2010

Stanley, H. E.; Buldyrev, S. V.; Franzese, G.
Journal of Physics: Condensed Matter, Vol. 22, Issue 28
DOI: 10.1088/0953-8984/22/28/284101

Observation of fragile-to-strong dynamic crossover in protein hydration water
journal, June 2006

Chen, S. -H.; Liu, L.; Fratini, E.
Proceedings of the National Academy of Sciences, Vol. 103, Issue 24
DOI: 10.1073/pnas.0602474103

The Endothermic Effects during Denaturation of Lysozyme by Temperature Modulated Calorimetry and an Intermediate Reaction Equilibrium
journal, June 2002

Salvetti, G.; Tombari, E.; Mikheeva, L.
The Journal of Physical Chemistry B, Vol. 106, Issue 23
DOI: 10.1021/jp025587d

Pressure Dependence of Fragile-to-Strong Transition and a Possible Second Critical Point in Supercooled Confined Water
journal, September 2005

Liu, Li; Chen, Sow-Hsin; Faraone, Antonio
Physical Review Letters, Vol. 95, Issue 11
DOI: 10.1103/PhysRevLett.95.117802

Experimental evidence of fragile-to-strong dynamic crossover in DNA hydration water
journal, November 2006

Chen, S. -H.; Liu, L.; Chu, X.
The Journal of Chemical Physics, Vol. 125, Issue 17
DOI: 10.1063/1.2372491

Crystalline ribonuclease A loses function below the dynamical transition at 220 K
journal, June 1992

Rasmussen, Bjarne F.; Stock, Ann M.; Ringe, Dagmar
Nature, Vol. 357, Issue 6377
DOI: 10.1038/357423a0

Hydrogen Bonding in Biological Structures
book, January 1991

Jeffrey, George A.; Saenger, Wolfram
DOI: 10.1007/978-3-642-85135-3

Communication: Protein dynamical transition vs. liquid-liquid phase transition in protein hydration water
journal, September 2013

Schirò, Giorgio; Fomina, Margarita; Cupane, Antonio
The Journal of Chemical Physics, Vol. 139, Issue 12
DOI: 10.1063/1.4822250

The liquid water polymorphism
journal, September 2009

Mallamace, F.
Proceedings of the National Academy of Sciences, Vol. 106, Issue 36
DOI: 10.1073/pnas.0908198106

Connections of activated hopping processes with the breakdown of the Stokes-Einstein relation and with aspects of dynamical heterogeneities
journal, October 2008

Chong, Song-Ho
Physical Review E, Vol. 78, Issue 4
DOI: 10.1103/PhysRevE.78.041501

Glass Transition Thermodynamics and Kinetics
journal, April 2013

Stillinger, Frank H.; Debenedetti, Pablo G.
Annual Review of Condensed Matter Physics, Vol. 4, Issue 1
DOI: 10.1146/annurev-conmatphys-030212-184329

A Possible Role of Water in the Protein Folding Process
journal, December 2011

Mallamace, Francesco; Corsaro, Carmelo; Mallamace, Domenico
The Journal of Physical Chemistry B, Vol. 115, Issue 48
DOI: 10.1021/jp205285t

Multiple relaxation processes versus the fragile-to-strong transition in confined water
journal, January 2011

Bruni, F.; Mancinelli, R.; Ricci, M. A.
Physical Chemistry Chemical Physics, Vol. 13, Issue 44
DOI: 10.1039/c1cp22029b

Similar Records in DOE PAGES and OSTI.GOV collections:

Some thermodynamical aspects of protein hydration water

Journal Article Mallamace, Francesco ; Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 ; Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215 ; ... - Journal of Chemical Physics

We study by means of nuclear magnetic resonance the self-diffusion of protein hydration water at different hydration levels across a large temperature range that includes the deeply supercooled regime. Starting with a single hydration shell (h = 0.3), we consider different hydrations up to h = 0.65. Our experimental evidence indicates that two phenomena play a significant role in the dynamics of protein hydration water: (i) the measured fragile-to-strong dynamic crossover temperature is unaffected by the hydration level and (ii) the first hydration shell remains liquid at all hydrations, even at the lowest temperature.
https://doi.org/10.1063/1.4921897
Some Aspects of the Liquid Water Thermodynamic Behavior: From The Stable to the Deep Supercooled Regime

Journal Article Mallamace, Francesco ; Mensitieri, Giuseppe ; Mallamace, Domenico ; ... - International Journal of Molecular Sciences (Online)

Liquid water is considered to be a peculiar example of glass forming materials because of the possibility of giving rise to amorphous phases with different densities and of the thermodynamic anomalies that characterize its supercooled liquid phase. In the present work, literature data on the density of bulk liquid water are analyzed in a wide temperature-pressure range, also including the glass phases. A careful data analysis, which was performed on different density isobars, made in terms of thermodynamic response functions, like the thermal expansion αP and the specific heat differences C_P-C_V, proves, exclusively from the experimental data, the thermodynamic consistencemore »« less
https://doi.org/10.3390/ijms21197269

Full Text Available
Hydration-dependent dynamic crossover phenomenon in protein hydration water

Journal Article Wang, Zhe ; Fratini, Emiliano ; Li, Mingda ; ... - Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

We present the characteristic relaxation time τ of protein hydration water exhibits a strong hydration level h dependence. The dynamic crossover is observed when h is higher than the monolayer hydration level h_c = 0.2 –0.25 and becomes more visible as h increases. When h is lower than h_c, τ only exhibits Arrhenius behavior in the measured temperature range. The activation energy of the Arrhenius behavior is insensitive to h , indicating a local-like motion. Furthermore, the h dependence of the crossover temperature shows that the protein dynamic transition is not directly or solely induced by the dynamic crossover inmore » the hydration water.« less
Cited by 11
https://doi.org/10.1103/physreve.90.042705

Full Text Available
Dynamics of a globular protein and its hydration water studied by neutron scattering and MD simulations

Journal Article Chen, Sow-Hsin ; Lagi, Marco ; Chu, Xiang-qiang ; ... - Spectroscopy

This review article describes our neutron scattering experiments made in the past four years for the understanding of the single-particle (hydrogen atom) dynamics of a protein and its hydration water and the strong coupling between them. We found that the key to this strong coupling is the existence of a fragile-to-strong dynamic crossover (FSC) phenomenon occurring at around T _L = 225±5 K in the hydration water. On lowering of the temperature toward FSC, the structure of hydration water makes a transition from predominantly the high density form (HDL), a more fluid state, to predominantly the low density form (LDL),more »« less
https://doi.org/10.1155/2010/284639
Dynamical behaviors of structural, constrained and free water in calcium- and magnesium-silicate-hydrate gels

Journal Article Le, Peisi ; Fratini, Emiliano ; Ito, Kanae ; ... - Journal of Colloid and Interface Science

We present the hypothesis that the mechanical properties of cement pastes depend strongly on their porosities. In a saturated paste, the porosity links to the free water volume after hydration. Structural water, constrained water, and free water have different dynamical behavior. Hence, it should be possible to extract information on pore system by exploiting the water dynamics. With our experiments we investigated the slow dynamics of hydration water confined in calcium- and magnesium-silicate-hydrate (C-S-H and M-S-H) gels using high-resolution quasi-elastic neutron scattering (QENS) technique. C-S-H and M-S-H are the chemical binders present in calcium rich and magnesium rich cements. Wemore »« less
Cited by 13
https://doi.org/10.1016/j.jcis.2016.01.071

Full Text Available

Similar Records

Title: Some thermodynamical aspects of protein hydration water

Citation Formats

Conductivity in Hydrated Proteins: No Signs of the Fragile-to-Strong Crossover journal, March 2008

Characterizing the secondary hydration shell on hydrated myoglobin, hemoglobin, and lysozyme powders by its vitrification behavior on cooling and its calorimetric glass-->liquid transition and crystallization behavior on reheating journal, December 1995

Glassy behavior of a protein journal, April 1989

Thermodynamic determination of fragility in liquids and a fragile-to-strong liquid transition in water journal, April 1999

Specific heat of hydrated lysozyme, water's contribution to its dynamics, and criteria for glass formation of biomaterials journal, September 2013

Evidence of the existence of the low-density liquid phase in supercooled, confined water journal, December 2006

Relaxation Processes in Supercooled Confined Water and Implications for Protein Dynamics journal, June 2006

Observation of a dynamic crossover in RNA hydration water which triggers a dynamic transition in the biopolymer journal, January 2008

The violation of the Stokes-Einstein relation in supercooled water journal, August 2006

The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain journal, April 1951

Transport properties of glass-forming liquids suggest that dynamic crossover temperature is as important as the glass transition temperature journal, December 2010

The role of the dynamic crossover temperature and the arrest in glass-forming fluids journal, September 2011

Self-Diffusion of Supercooled Water to 238 K Using PGSE NMR Diffusion Measurements journal, January 1999

Observation of high-temperature dynamic crossover in protein hydration water and its relation to reversible denaturation of lysozyme journal, April 2009

Thermodynamic properties of bulk and confined water journal, November 2014

How Soft Is a Protein? A Protein Dynamics Force Constant Measured by Neutron Scattering journal, June 2000

Thermal motions and function of bacteriorhodopsin in purple membranes: effects of temperature and hydration studied by neutron scattering. journal, October 1993

Role of Protein-Water Hydrogen Bond Dynamics in the Protein Dynamical Transition journal, March 2002

Appearance of a fractional Stokes–Einstein relation in water and a structural interpretation of its onset journal, July 2009

Solvent dependence of dynamic transitions in protein solutions journal, August 2000

Cooperative charge fluctuations by migrating protons in globular proteins journal, November 1998

Physical Origin of Anharmonic Dynamics in Proteins: New Insights From Resolution-Dependent Neutron Scattering on Homomeric Polypeptides journal, September 2012

The Low-Temperature Dynamic Crossover Phenomenon in Protein Hydration Water: Simulations vs Experiments journal, February 2008

Nanosecond Relaxation Dynamics of Hydrated Proteins: Water versus Protein Contributions journal, May 2011

Role of the solvent in the dynamical transitions of proteins: The case of the lysozyme-water system journal, July 2007

Behind the folding funnel diagram journal, June 2011

Hydration-dependent dynamic crossover phenomenon in protein hydration water journal, October 2014

A singular thermodynamically consistent temperature at the origin of the anomalous behavior of liquid water journal, December 2012

Calorimetric studies of the kinetic unfreezing of molecular motions in hydrated lysozyme, hemoglobin, and myoglobin journal, January 1994

Water Mediation in Protein Folding and Molecular Recognition journal, June 2006

Origins of Apparent Fragile-to-Strong Transitions of Protein Hydration Waters journal, November 2008

The protein glass transition as measured by dielectric spectroscopy and differential scanning calorimetry journal, January 2010

Hydration dependence of myoglobin dynamics studied with elastic neutron scattering, differential scanning calorimetry and broadband dielectric spectroscopy journal, January 2014

A consistent picture of protein dynamics. journal, November 1984

Liquid polymorphism: water in nanoconfined and biological environments journal, June 2010

Observation of fragile-to-strong dynamic crossover in protein hydration water journal, June 2006

The Endothermic Effects during Denaturation of Lysozyme by Temperature Modulated Calorimetry and an Intermediate Reaction Equilibrium journal, June 2002

Pressure Dependence of Fragile-to-Strong Transition and a Possible Second Critical Point in Supercooled Confined Water journal, September 2005

Experimental evidence of fragile-to-strong dynamic crossover in DNA hydration water journal, November 2006

Crystalline ribonuclease A loses function below the dynamical transition at 220 K journal, June 1992

Hydrogen Bonding in Biological Structures book, January 1991

Communication: Protein dynamical transition vs. liquid-liquid phase transition in protein hydration water journal, September 2013

The liquid water polymorphism journal, September 2009

Connections of activated hopping processes with the breakdown of the Stokes-Einstein relation and with aspects of dynamical heterogeneities journal, October 2008

Glass Transition Thermodynamics and Kinetics journal, April 2013

A Possible Role of Water in the Protein Folding Process journal, December 2011

Multiple relaxation processes versus the fragile-to-strong transition in confined water journal, January 2011

Conductivity in Hydrated Proteins: No Signs of the Fragile-to-Strong Crossover
journal, March 2008

Characterizing the secondary hydration shell on hydrated myoglobin, hemoglobin, and lysozyme powders by its vitrification behavior on cooling and its calorimetric glass-->liquid transition and crystallization behavior on reheating
journal, December 1995

Glassy behavior of a protein
journal, April 1989

Thermodynamic determination of fragility in liquids and a fragile-to-strong liquid transition in water
journal, April 1999

Specific heat of hydrated lysozyme, water's contribution to its dynamics, and criteria for glass formation of biomaterials
journal, September 2013

Evidence of the existence of the low-density liquid phase in supercooled, confined water
journal, December 2006

Relaxation Processes in Supercooled Confined Water and Implications for Protein Dynamics
journal, June 2006

Observation of a dynamic crossover in RNA hydration water which triggers a dynamic transition in the biopolymer
journal, January 2008

The violation of the Stokes-Einstein relation in supercooled water
journal, August 2006

The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain
journal, April 1951

Transport properties of glass-forming liquids suggest that dynamic crossover temperature is as important as the glass transition temperature
journal, December 2010

The role of the dynamic crossover temperature and the arrest in glass-forming fluids
journal, September 2011

Self-Diffusion of Supercooled Water to 238 K Using PGSE NMR Diffusion Measurements
journal, January 1999

Observation of high-temperature dynamic crossover in protein hydration water and its relation to reversible denaturation of lysozyme
journal, April 2009

Thermodynamic properties of bulk and confined water
journal, November 2014

How Soft Is a Protein? A Protein Dynamics Force Constant Measured by Neutron Scattering
journal, June 2000

Thermal motions and function of bacteriorhodopsin in purple membranes: effects of temperature and hydration studied by neutron scattering.
journal, October 1993

Role of Protein-Water Hydrogen Bond Dynamics in the Protein Dynamical Transition
journal, March 2002

Appearance of a fractional Stokes–Einstein relation in water and a structural interpretation of its onset
journal, July 2009

Solvent dependence of dynamic transitions in protein solutions
journal, August 2000

Cooperative charge fluctuations by migrating protons in globular proteins
journal, November 1998

Physical Origin of Anharmonic Dynamics in Proteins: New Insights From Resolution-Dependent Neutron Scattering on Homomeric Polypeptides
journal, September 2012

The Low-Temperature Dynamic Crossover Phenomenon in Protein Hydration Water: Simulations vs Experiments
journal, February 2008

Nanosecond Relaxation Dynamics of Hydrated Proteins: Water versus Protein Contributions
journal, May 2011

Role of the solvent in the dynamical transitions of proteins: The case of the lysozyme-water system
journal, July 2007

Behind the folding funnel diagram
journal, June 2011

Hydration-dependent dynamic crossover phenomenon in protein hydration water
journal, October 2014

A singular thermodynamically consistent temperature at the origin of the anomalous behavior of liquid water
journal, December 2012

Calorimetric studies of the kinetic unfreezing of molecular motions in hydrated lysozyme, hemoglobin, and myoglobin
journal, January 1994

Water Mediation in Protein Folding and Molecular Recognition
journal, June 2006

Origins of Apparent Fragile-to-Strong Transitions of Protein Hydration Waters
journal, November 2008

The protein glass transition as measured by dielectric spectroscopy and differential scanning calorimetry
journal, January 2010

Hydration dependence of myoglobin dynamics studied with elastic neutron scattering, differential scanning calorimetry and broadband dielectric spectroscopy
journal, January 2014

A consistent picture of protein dynamics.
journal, November 1984

Liquid polymorphism: water in nanoconfined and biological environments
journal, June 2010

Observation of fragile-to-strong dynamic crossover in protein hydration water
journal, June 2006

The Endothermic Effects during Denaturation of Lysozyme by Temperature Modulated Calorimetry and an Intermediate Reaction Equilibrium
journal, June 2002

Pressure Dependence of Fragile-to-Strong Transition and a Possible Second Critical Point in Supercooled Confined Water
journal, September 2005

Experimental evidence of fragile-to-strong dynamic crossover in DNA hydration water
journal, November 2006

Crystalline ribonuclease A loses function below the dynamical transition at 220 K
journal, June 1992

Hydrogen Bonding in Biological Structures
book, January 1991

Communication: Protein dynamical transition vs. liquid-liquid phase transition in protein hydration water
journal, September 2013

The liquid water polymorphism
journal, September 2009

Connections of activated hopping processes with the breakdown of the Stokes-Einstein relation and with aspects of dynamical heterogeneities
journal, October 2008

Glass Transition Thermodynamics and Kinetics
journal, April 2013

A Possible Role of Water in the Protein Folding Process
journal, December 2011

Multiple relaxation processes versus the fragile-to-strong transition in confined water
journal, January 2011