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Title: Modern plant metabolomics: Advanced natural product gene discoveries, improved technologies, and future prospects

Plant metabolomics has matured and modern plant metabolomics has accelerated gene discoveries and the elucidation of a variety of plant natural product biosynthetic pathways. This study highlights specific examples of the discovery and characterization of novel genes and enzymes associated with the biosynthesis of natural products such as flavonoids, glucosinolates, terpenoids, and alkaloids. Additional examples of the integration of metabolomics with genome-based functional characterizations of plant natural products that are important to modern pharmaceutical technology are also reviewed. This article also provides a substantial review of recent technical advances in mass spectrometry imaging, nuclear magnetic resonance imaging, integrated LC-MS-SPE-NMR for metabolite identifications, and x-ray crystallography of microgram quantities for structural determinations. The review closes with a discussion on the future prospects of metabolomics related to crop species and herbal medicine.
Authors:
 [1] ;  [1] ;  [2] ;  [3]
  1. The Samuel Roberts Noble Foundation, Ardmore, OK (United States)
  2. Iowa State Univ., Ames, IA (United States); Ames Lab., Ames, IA (United States)
  3. RIKEN Center for Sustainable Resource Science, Tsurumi-ku (Japan); Chiba Univ., Chuo-ku (Japan)
Publication Date:
OSTI Identifier:
1227150
Report Number(s):
IS-J--8609
Journal ID: ISSN 0265-0568; NPRRDF
Grant/Contract Number:
AC02-07CH11358
Type:
Accepted Manuscript
Journal Name:
Natural Product Reports
Additional Journal Information:
Journal Volume: 32; Journal Issue: 2; Journal ID: ISSN 0265-0568
Publisher:
Royal Society of Chemistry
Research Org:
Ames Laboratory (AMES), Ames, IA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES