Quantifying the impact of decay in bed-net efficacy on malaria transmission

Ngonghala, Calistus N.; Del Valle, Sara Y.; Zhao, Ruijun; Mohammed-Awel, Jemal

doi:10.1016/j.jtbi.2014.08.018

Title: Quantifying the impact of decay in bed-net efficacy on malaria transmission

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Abstract

Insecticide-treated nets (ITNs) are at the forefront of malaria control programs and even though the percentage of households in sub-Saharan Africa that owned nets increased from 3% in 2000 to 53% in 2012, many children continue to die from malaria. The potential impact of ITNs on reducing malaria transmission is limited due to inconsistent or improper use, as well as physical decay in effectiveness. Most mathematical models for malaria transmission have assumed a fixed effectiveness rate for bed-nets, which can overestimate the impact of nets on malaria control. We develop a model for malaria spread that captures the decrease in ITN effectiveness due to physical and chemical decay, as well as human behavior as a function of time. We perform uncertainty and sensitivity analyses to identify and rank parameters that play a critical role in malaria transmission. These analyses show that the basic reproduction number R₀, and the infectious human population are most sensitive to bed-net coverage and the biting rate of mosquitoes. Our results show the existence of a backward bifurcation for the case in which ITN efficacy is constant over time, which occurs for some range of parameters and is characterized by high malaria mortality in humans. Thismore »« less

Authors:

; Del Valle, Sara Y.;

;

Publication Date:: Mon Dec 01 00:00:00 EST 2014

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1226836

Alternate Identifier(s):: OSTI ID: 1212143

Grant/Contract Number:: AC52-06NA25396; U01-GM097658-01

Resource Type:: Published Article

Journal Name:: Journal of Theoretical Biology

Additional Journal Information:: Journal Name: Journal of Theoretical Biology Journal Volume: 363 Journal Issue: C; Journal ID: ISSN 0022-5193

Publisher:: Elsevier

Country of Publication:: United Kingdom

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; malaria control; insecticide-treated nets; backward bifurcation; human behavior; sensitivity analysis

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                    Ngonghala, Calistus N., Del Valle, Sara Y., Zhao, Ruijun, and Mohammed-Awel, Jemal. Quantifying the impact of decay in bed-net efficacy on malaria transmission.  United Kingdom: N. p., 2014. 
Web.  doi:10.1016/j.jtbi.2014.08.018.

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                    Ngonghala, Calistus N., Del Valle, Sara Y., Zhao, Ruijun, & Mohammed-Awel, Jemal. Quantifying the impact of decay in bed-net efficacy on malaria transmission.  United Kingdom.  https://doi.org/10.1016/j.jtbi.2014.08.018

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                    Ngonghala, Calistus N., Del Valle, Sara Y., Zhao, Ruijun, and Mohammed-Awel, Jemal. Mon .  
"Quantifying the impact of decay in bed-net efficacy on malaria transmission".  United Kingdom.  https://doi.org/10.1016/j.jtbi.2014.08.018.

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@article{osti_1226836,

  title        = {Quantifying the impact of decay in bed-net efficacy on malaria transmission},

  author       = {Ngonghala, Calistus N. and Del Valle, Sara Y. and Zhao, Ruijun and Mohammed-Awel, Jemal},

  abstractNote = {Insecticide-treated nets (ITNs) are at the forefront of malaria control programs and even though the percentage of households in sub-Saharan Africa that owned nets increased from 3% in 2000 to 53% in 2012, many children continue to die from malaria. The potential impact of ITNs on reducing malaria transmission is limited due to inconsistent or improper use, as well as physical decay in effectiveness. Most mathematical models for malaria transmission have assumed a fixed effectiveness rate for bed-nets, which can overestimate the impact of nets on malaria control. We develop a model for malaria spread that captures the decrease in ITN effectiveness due to physical and chemical decay, as well as human behavior as a function of time. We perform uncertainty and sensitivity analyses to identify and rank parameters that play a critical role in malaria transmission. These analyses show that the basic reproduction number R0, and the infectious human population are most sensitive to bed-net coverage and the biting rate of mosquitoes. Our results show the existence of a backward bifurcation for the case in which ITN efficacy is constant over time, which occurs for some range of parameters and is characterized by high malaria mortality in humans. This result implies that bringing R0 to less than one is not enough for malaria elimination but rather additional efforts will be necessary to control the disease. For the case in which ITN efficacy decays over time, we determine coverage levels required to control malaria for different ITN efficacies and demonstrate that ITNs with longer useful lifespans perform better in malaria control. We conclude that malaria control programs should focus on increasing bed-net coverage, which can be achieved by enhancing malaria education and increasing bed-net distribution in malaria endemic regions.},

  doi          = {10.1016/j.jtbi.2014.08.018},

  journal      = {Journal of Theoretical Biology},

  number       = C,

  volume       = 363,

  place        = {United Kingdom},

  year         = {Mon Dec 01 00:00:00 EST 2014},

  month        = {Mon Dec 01 00:00:00 EST 2014}

}

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