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Title: Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine

In this study, blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.
Authors:
 [1] ;  [2] ;  [2] ;  [2] ;  [3] ;  [2] ;  [3] ;  [4] ;  [4] ;  [2] ;  [5] ;  [2]
  1. Osaka Univ., Osaka (Japan)
  2. Basel Univ., Basel (Switzerland); Basel Univ. Hospital, Basel (Switzerland)
  3. Basel Univ. Hospital, Basel (Switzerland)
  4. Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (Switzerland)
  5. Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne (Switzerland); Univ. of Chicago, Chicago, IL (United States); Argonne National Lab., Argonne, IL (United States)
Publication Date:
OSTI Identifier:
1225190
Grant/Contract Number:
AC02-06CH11357
Type:
Accepted Manuscript
Journal Name:
Frontiers in Bioengineering and Biotechnology
Additional Journal Information:
Journal Volume: 3; Journal Issue: 3; Journal ID: ISSN 2296-4185
Publisher:
Frontiers Research Foundation
Research Org:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES angiogenesis; growth factors; extracellular matrix; fibrin; protein engineering