Biological responses to engineered nanomaterials: Needs for the next decade
Abstract
In this study, the interaction of nanomaterials with biomolecules, cells, and organisms is an enormously vital area of current research, with applications in nanoenabled diagnostics, imaging agents, therapeutics, and contaminant removal technologies. Yet the potential for adverse biological and environmental impacts of nanomaterial exposure is considerable and needs to be addressed to ensure sustainable development of nanomaterials. In this Outlook four research needs for the next decade are outlined: (i) measurement of the chemical nature of nanomaterials in dynamic, complex aqueous environments; (ii) real-time measurements of nanomaterial-biological interactions with chemical specificity; (iii) delineation of molecular modes of action for nanomaterial effects on living systems as functions of nanomaterial properties; and (iv) an integrated systems approach that includes computation and simulation across orders of magnitude in time and space.
- Authors:
-
- Univ. of Illinois, Urbana-Champaign, IL (United States)
- Northwestern Univ., Evanston, IL (United States)
- Univ. of Wisconsin, Madison, WI (United States)
- Univ. of Minnesota, Minneapolis, MN (United States)
- Georgia Inst. of Technology, Atlanta, GA (United States)
- Univ. of Wisconsin, Milwaukee, WI (United States)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Univ. of Maryland, Baltimore, MD (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1224506
- Report Number(s):
- PNNL-SA-113908
Journal ID: ISSN 2374-7943; 47975; KP1704020
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- ACS Central Science
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 3; Journal ID: ISSN 2374-7943
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY; nanomaterials; biomolecules; cells; organisms; biological interactions; Environmental Molecular Sciences Laboratory
Citation Formats
Murphy, Catherine J., Vartanian, Ariane M., Geiger, Franz M., Hamers, Robert J., Pedersen, Joel A., Cui, Qiang, Haynes, Christy L., Carlson, Erin E., Hernandez, Rigoberto, Klaper, Rebecca D., Orr, Galya, and Rosenzweig, Ze'ev. Biological responses to engineered nanomaterials: Needs for the next decade. United States: N. p., 2015.
Web. doi:10.1021/acscentsci.5b00182.
Murphy, Catherine J., Vartanian, Ariane M., Geiger, Franz M., Hamers, Robert J., Pedersen, Joel A., Cui, Qiang, Haynes, Christy L., Carlson, Erin E., Hernandez, Rigoberto, Klaper, Rebecca D., Orr, Galya, & Rosenzweig, Ze'ev. Biological responses to engineered nanomaterials: Needs for the next decade. United States. https://doi.org/10.1021/acscentsci.5b00182
Murphy, Catherine J., Vartanian, Ariane M., Geiger, Franz M., Hamers, Robert J., Pedersen, Joel A., Cui, Qiang, Haynes, Christy L., Carlson, Erin E., Hernandez, Rigoberto, Klaper, Rebecca D., Orr, Galya, and Rosenzweig, Ze'ev. Tue .
"Biological responses to engineered nanomaterials: Needs for the next decade". United States. https://doi.org/10.1021/acscentsci.5b00182. https://www.osti.gov/servlets/purl/1224506.
@article{osti_1224506,
title = {Biological responses to engineered nanomaterials: Needs for the next decade},
author = {Murphy, Catherine J. and Vartanian, Ariane M. and Geiger, Franz M. and Hamers, Robert J. and Pedersen, Joel A. and Cui, Qiang and Haynes, Christy L. and Carlson, Erin E. and Hernandez, Rigoberto and Klaper, Rebecca D. and Orr, Galya and Rosenzweig, Ze'ev},
abstractNote = {In this study, the interaction of nanomaterials with biomolecules, cells, and organisms is an enormously vital area of current research, with applications in nanoenabled diagnostics, imaging agents, therapeutics, and contaminant removal technologies. Yet the potential for adverse biological and environmental impacts of nanomaterial exposure is considerable and needs to be addressed to ensure sustainable development of nanomaterials. In this Outlook four research needs for the next decade are outlined: (i) measurement of the chemical nature of nanomaterials in dynamic, complex aqueous environments; (ii) real-time measurements of nanomaterial-biological interactions with chemical specificity; (iii) delineation of molecular modes of action for nanomaterial effects on living systems as functions of nanomaterial properties; and (iv) an integrated systems approach that includes computation and simulation across orders of magnitude in time and space.},
doi = {10.1021/acscentsci.5b00182},
journal = {ACS Central Science},
number = 3,
volume = 1,
place = {United States},
year = {Tue Jun 09 00:00:00 EDT 2015},
month = {Tue Jun 09 00:00:00 EDT 2015}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 107 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Nanotechnology: Societal Implications
book, January 2007
- Roco, Mihail C.; Bainbridge, William Sims
- Springer Dordrecht
Semiconductor Clusters, Nanocrystals, and Quantum Dots
journal, February 1996
- Alivisatos, A. P.
- Science, Vol. 271, Issue 5251, p. 933-937
The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment
journal, January 2003
- Kelly, K. Lance; Coronado, Eduardo; Zhao, Lin Lin
- The Journal of Physical Chemistry B, Vol. 107, Issue 3
Chemistry and Properties of Nanocrystals of Different Shapes
journal, April 2005
- Burda, Clemens; Chen, Xiaobo; Narayanan, Radha
- Chemical Reviews, Vol. 105, Issue 4
Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
journal, October 1995
- Liversidge, Gary G.; Cundy, Kenneth C.
- International Journal of Pharmaceutics, Vol. 125, Issue 1
Environmental Risks of Nanotechnology: National Nanotechnology Initiative Funding, 2000−2004
journal, March 2006
- Dunphy Guzmán, Katherine A.; Taylor, Margaret R.; Banfield, Jillian F.
- Environmental Science & Technology, Vol. 40, Issue 5
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
journal, March 2000
- Maeda, H.; Wu, J.; Sawa, T.
- Journal of Controlled Release, Vol. 65, Issue 1-2
Nanoparticle therapeutics: an emerging treatment modality for cancer
journal, September 2008
- Davis, Mark E.; Chen, Zhuo; Shin, Dong M.
- Nature Reviews Drug Discovery, Vol. 7, Issue 9
Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
journal, February 2014
- Bertrand, Nicolas; Wu, Jun; Xu, Xiaoyang
- Advanced Drug Delivery Reviews, Vol. 66
Mixed-Charge Nanoparticles for Long Circulation, Low Reticuloendothelial System Clearance, and High Tumor Accumulation
journal, February 2014
- Liu, Xiangsheng; Li, Huan; Chen, Yangjun
- Advanced Healthcare Materials, Vol. 3, Issue 9
Immunotargeted Nanoshells for Integrated Cancer Imaging and Therapy
journal, April 2005
- Loo, Christopher; Lowery, Amanda; Halas, Naomi
- Nano Letters, Vol. 5, Issue 4
Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
journal, February 2006
- Huang, Xiaohua; El-Sayed, Ivan H.; Qian, Wei
- Journal of the American Chemical Society, Vol. 128, Issue 6, p. 2115-2120
In vivo cancer targeting and imaging with semiconductor quantum dots
journal, July 2004
- Gao, Xiaohu; Cui, Yuanyuan; Levenson, Richard M.
- Nature Biotechnology, Vol. 22, Issue 8
Multifunctional magnetic nanoparticles for targeted imaging and therapy☆
journal, August 2008
- Mccarthy, J.; Weissleder, R.
- Advanced Drug Delivery Reviews, Vol. 60, Issue 11
Nanosilver as a new generation of nanoproduct in biomedical applications
journal, November 2010
- Chaloupka, Karla; Malam, Yogeshkumar; Seifalian, Alexander M.
- Trends in Biotechnology, Vol. 28, Issue 11
Theranostic nanoparticles for future personalized medicine
journal, September 2014
- Ryu, Ju Hee; Lee, Sangmin; Son, Sohee
- Journal of Controlled Release, Vol. 190
Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis
journal, April 2013
- Rehman, Zia ur; Hoekstra, Dick; Zuhorn, Inge S.
- ACS Nano, Vol. 7, Issue 5
Nanoparticle albumin-bound paclitaxel: a novel Cremphor-EL ® -free formulation of paclitaxel
journal, August 2007
- Stinchcombe, Thomas E.
- Nanomedicine, Vol. 2, Issue 4
Toxicology and clinical potential of nanoparticles
journal, December 2011
- Yildirimer, Lara; Thanh, Nguyen T. K.; Loizidou, Marilena
- Nano Today, Vol. 6, Issue 6
Gold nanoparticles as novel agents for cancer therapy
journal, February 2012
- Jain, S.; Hirst, D. G.; O'Sullivan, J. M.
- The British Journal of Radiology, Vol. 85, Issue 1010
Development of cathode materials for lithium ion rechargeable batteries based on the system Li(Ni1/3Mn1/3Co(1/3-x)Mx)O2, (M=Mg, Fe, Al and x=0.00 to 0.33)
journal, December 2014
- Samarasingha, Pushpaka B.; Wijayasinghe, Athula; Behm, Mårten
- Solid State Ionics, Vol. 268
Science and technology for water purification in the coming decades
journal, March 2008
- Shannon, Mark A.; Bohn, Paul W.; Elimelech, Menachem
- Nature, Vol. 452, Issue 7185, p. 301-310
A review on nanomaterials for environmental remediation
journal, January 2012
- Khin, Mya Mya; Nair, A. Sreekumaran; Babu, V. Jagadeesh
- Energy & Environmental Science, Vol. 5, Issue 8
Quantum dot light-emitting devices
journal, September 2013
- Talapin, Dmitri V.; Steckel, Jonathan
- MRS Bulletin, Vol. 38, Issue 9
The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
journal, November 2012
- Fröhlich, Eleonore
- International Journal of Nanomedicine
Implementation of alternative test strategies for the safety assessment of engineered nanomaterials
journal, July 2013
- Nel, A. E.
- Journal of Internal Medicine, Vol. 274, Issue 6
Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants
journal, January 2007
- Pulskamp, K.; Diabate, S.; Krug, H.
- Toxicology Letters, Vol. 168, Issue 1
Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects
journal, March 2009
- Alkilany, Alaaldin M.; Nagaria, Pratik K.; Hexel, Cole R.
- Small, Vol. 5, Issue 6
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
journal, September 2008
- Lundqvist, M.; Stigler, J.; Elia, G.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 38
Nanoparticle-induced surface reconstruction of phospholipid membranes
journal, November 2008
- Wang, B.; Zhang, L.; Bae, S. C.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 47
Role of Nanoparticle Surface Functionality in the Disruption of Model Cell Membranes
journal, September 2012
- Moghadam, Babak Y.; Hou, Wen-Che; Corredor, Charlie
- Langmuir, Vol. 28, Issue 47
Electrical Method to Quantify Nanoparticle Interaction with Lipid Bilayers
journal, January 2013
- Carney, Randy P.; Astier, Yann; Carney, Tamara M.
- ACS Nano, Vol. 7, Issue 2
Direct Probes of 4 nm Diameter Gold Nanoparticles Interacting with Supported Lipid Bilayers
journal, December 2014
- Troiano, Julianne M.; Olenick, Laura L.; Kuech, Thomas R.
- The Journal of Physical Chemistry C, Vol. 119, Issue 1
In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice
journal, February 2007
- Tada, Hiroshi; Higuchi, Hideo; Wanatabe, Tomonobu M.
- Cancer Research, Vol. 67, Issue 3
Simultaneous Single-Particle Superlocalization and Rotational Tracking
journal, January 2013
- Gu, Yan; Wang, Gufeng; Fang, Ning
- ACS Nano, Vol. 7, Issue 2
Enzyme-Directed Assembly of Nanoparticles in Tumors Monitored by in Vivo Whole Animal Imaging and ex Vivo Super-Resolution Fluorescence Imaging
journal, December 2013
- Chien, Miao-Ping; Carlini, Andrea S.; Hu, Dehong
- Journal of the American Chemical Society, Vol. 135, Issue 50
Probing Rotational and Translational Diffusion of Nanodoublers in Living Cells on Microsecond Time Scales
journal, April 2014
- Macias-Romero, Carlos; Didier, Marie E. P.; Zubkovs, Vitalijs
- Nano Letters, Vol. 14, Issue 5
Biomolecular Imaging with Coherent Nonlinear Vibrational Microscopy
journal, April 2013
- Chung, Chao-Yu; Potma, Eric O.
- Annual Review of Physical Chemistry, Vol. 64, Issue 1
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?
journal, April 2010
- Alkilany, Alaaldin M.; Murphy, Catherine J.
- Journal of Nanoparticle Research, Vol. 12, Issue 7
Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
journal, June 2013
- Bondarenko, Olesja; Juganson, Katre; Ivask, Angela
- Archives of Toxicology, Vol. 87, Issue 7
Molecular interactions of nanomaterials and organisms: defining biomarkers for toxicity and high-throughput screening using traditional and next-generation sequencing approaches
journal, January 2014
- Klaper, Rebecca; Arndt, Devrah; Bozich, Jared
- The Analyst, Vol. 139, Issue 5
Interlaboratory Evaluation of in Vitro Cytotoxicity and Inflammatory Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium
journal, June 2013
- Xia, Tian; Hamilton, Raymond F.; Bonner, James C.
- Environmental Health Perspectives, Vol. 121, Issue 6
Are Quantum Dots Toxic? Exploring the Discrepancy Between Cell Culture and Animal Studies
journal, July 2012
- Tsoi, Kim M.; Dai, Qin; Alman, Benjamin A.
- Accounts of Chemical Research, Vol. 46, Issue 3
Adsorption of Cellular Proteins to Polyelectrolyte-Functionalized Gold Nanorods: A Mechanism for Nanoparticle Regulation of Cell Phenotype?
journal, February 2014
- Sisco, Patrick N.; Wilson, Christopher G.; Chernak, Davin
- PLoS ONE, Vol. 9, Issue 2
NanoMiner — Integrative Human Transcriptomics Data Resource for Nanoparticle Research
journal, July 2013
- Kong, Lingjia; Tuomela, Soile; Hahne, Lauri
- PLoS ONE, Vol. 8, Issue 7
Assessing the Effect of Surface Chemistry on Gold Nanorod Uptake, Toxicity, and Gene Expression in Mammalian Cells
journal, January 2008
- Hauck, Tanya S.; Ghazani, Arezou A.; Chan, Warren C. W.
- Small, Vol. 4, Issue 1
Zebrafish High-Throughput Screening to Study the Impact of Dissolvable Metal Oxide Nanoparticles on the Hatching Enzyme, ZHE1
journal, November 2012
- Lin, Sijie; Zhao, Yan; Ji, Zhaoxia
- Small, Vol. 9, Issue 9-10
Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles
journal, May 2014
- Albanese, Alexandre; Walkey, Carl D.; Olsen, Jonathan B.
- ACS Nano, Vol. 8, Issue 6
Understanding the Toxicity of Carbon Nanotubes
journal, July 2012
- Liu, Ying; Zhao, Yuliang; Sun, Baoyun
- Accounts of Chemical Research, Vol. 46, Issue 3
Core Structure and Surface Functionalization of Carbon Nanomaterials Alter Impacts to Daphnid Mortality, Reproduction, and Growth: Acute Assays Do Not Predict Chronic Exposure Impacts
journal, July 2013
- Arndt, Devrah A.; Moua, Maika; Chen, Jian
- Environmental Science & Technology, Vol. 47, Issue 16
Mechanism of Silver Nanoparticle Toxicity Is Dependent on Dissolved Silver and Surface Coating in Caenorhabditis elegans
journal, December 2011
- Yang, Xinyu; Gondikas, Andreas P.; Marinakos, Stella M.
- Environmental Science & Technology, Vol. 46, Issue 2
Toxicity of CeO2 nanoparticles at different trophic levels – Effects on diatoms, chironomids and amphibians
journal, February 2015
- Bour, Agathe; Mouchet, Florence; Verneuil, Laurent
- Chemosphere, Vol. 120
Molecularly stabilised ultrasmall gold nanoparticles: synthesis, characterization and bioactivity
journal, January 2013
- Leifert, Annika; Pan-Bartnek, Yu; Simon, Ulrich
- Nanoscale, Vol. 5, Issue 14
Size-Dependent Electrocatalytic Reduction of CO 2 over Pd Nanoparticles
journal, March 2015
- Gao, Dunfeng; Zhou, Hu; Wang, Jing
- Journal of the American Chemical Society, Vol. 137, Issue 13
Ab-initio simulations of materials using VASP: Density-functional theory and beyond
journal, October 2008
- Hafner, Jürgen
- Journal of Computational Chemistry, Vol. 29, Issue 13
Advances in Correlated Electronic Structure Methods for Solids, Surfaces, and Nanostructures
journal, May 2008
- Huang, Patrick; Carter, Emily A.
- Annual Review of Physical Chemistry, Vol. 59, Issue 1
Constant pH Molecular Dynamics in Explicit Solvent with λ-Dynamics
journal, May 2011
- Donnini, Serena; Tegeler, Florian; Groenhof, Gerrit
- Journal of Chemical Theory and Computation, Vol. 7, Issue 6
An Explicit Consideration of Desolvation is Critical to Binding Free Energy Calculations of Charged Molecules at Ionic Surfaces
journal, October 2013
- Mori, Toshifumi; Hamers, Robert J.; Pedersen, Joel A.
- Journal of Chemical Theory and Computation, Vol. 9, Issue 11
Equilibrium Sampling in Biomolecular Simulations
journal, June 2011
- Zuckerman, Daniel M.
- Annual Review of Biophysics, Vol. 40, Issue 1
Multiple branched adaptive steered molecular dynamics
journal, August 2014
- Ozer, Gungor; Keyes, Thomas; Quirk, Stephen
- The Journal of Chemical Physics, Vol. 141, Issue 6
Adaptive Steered Molecular Dynamics of the Long-Distance Unfolding of Neuropeptide Y
journal, September 2010
- Ozer, Gungor; Valeev, Edward F.; Quirk, Stephen
- Journal of Chemical Theory and Computation, Vol. 6, Issue 10
A New Coarse-Grained Force Field for Membrane–Peptide Simulations
journal, October 2011
- Wu, Zhe; Cui, Qiang; Yethiraj, Arun
- Journal of Chemical Theory and Computation, Vol. 7, Issue 11
Perspective on the Martini model
journal, January 2013
- Marrink, Siewert J.; Tieleman, D. Peter
- Chemical Society Reviews, Vol. 42, Issue 16
Penetration of lipid bilayers by nanoparticles with environmentally-responsive surfaces: simulations and theory
journal, January 2011
- Van Lehn, Reid C.; Alexander-Katz, Alfredo
- Soft Matter, Vol. 7, Issue 24
Cationic Au Nanoparticle Binding with Plasma Membrane-like Lipid Bilayers: Potential Mechanism for Spontaneous Permeation to Cells Revealed by Atomistic Simulations
journal, May 2014
- Heikkilä, Elena; Martinez-Seara, Hector; Gurtovenko, Andrey A.
- The Journal of Physical Chemistry C, Vol. 118, Issue 20
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics
journal, May 2013
- Zhao, Gongpu; Perilla, Juan R.; Yufenyuy, Ernest L.
- Nature, Vol. 497, Issue 7451
Super-resolved Fluorescence Microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner
journal, November 2014
- Möckl, Leonhard; Lamb, Don C.; Bräuchle, Christoph
- Angewandte Chemie International Edition, Vol. 53, Issue 51
Fast, three-dimensional super-resolution imaging of live cells
journal, May 2011
- Jones, Sara A.; Shim, Sang-Hee; He, Jiang
- Nature Methods, Vol. 8, Issue 6
Emerging Techniques in Proteomics for Probing Nano–Bio Interactions
journal, November 2012
- Lai, Zon W.; Yan, Yan; Caruso, Frank
- ACS Nano, Vol. 6, Issue 12
Nanoproteomics: a new sprout from emerging links between nanotechnology and proteomics
journal, February 2013
- Jia, Lee; Lu, Yusheng; Shao, Jingwei
- Trends in Biotechnology, Vol. 31, Issue 2
Super-resolved Fluorescence Microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner
journal, November 2014
- Möckl, Leonhard; Lamb, Don C.; Bräuchle, Christoph
- Angewandte Chemie International Edition, Vol. 53, Issue 51
Ab-initio simulations of materials using VASP: Density-functional theory and beyond
journal, October 2008
- Hafner, Jürgen
- Journal of Computational Chemistry, Vol. 29, Issue 13
Assessing the Effect of Surface Chemistry on Gold Nanorod Uptake, Toxicity, and Gene Expression in Mammalian Cells
journal, January 2008
- Hauck, Tanya S.; Ghazani, Arezou A.; Chan, Warren C. W.
- Small, Vol. 4, Issue 1
Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects
journal, March 2009
- Alkilany, Alaaldin M.; Nagaria, Pratik K.; Hexel, Cole R.
- Small, Vol. 5, Issue 6
Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
journal, June 2013
- Bondarenko, Olesja; Juganson, Katre; Ivask, Angela
- Archives of Toxicology, Vol. 87, Issue 7
Toxicity of CeO2 nanoparticles at different trophic levels – Effects on diatoms, chironomids and amphibians
journal, February 2015
- Bour, Agathe; Mouchet, Florence; Verneuil, Laurent
- Chemosphere, Vol. 120
Nanosilver as a new generation of nanoproduct in biomedical applications
journal, November 2010
- Chaloupka, Karla; Malam, Yogeshkumar; Seifalian, Alexander M.
- Trends in Biotechnology, Vol. 28, Issue 11
Nanoproteomics: a new sprout from emerging links between nanotechnology and proteomics
journal, February 2013
- Jia, Lee; Lu, Yusheng; Shao, Jingwei
- Trends in Biotechnology, Vol. 31, Issue 2
Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants
journal, January 2007
- Pulskamp, K.; Diabate, S.; Krug, H.
- Toxicology Letters, Vol. 168, Issue 1
Understanding the Toxicity of Carbon Nanotubes
journal, July 2012
- Liu, Ying; Zhao, Yuliang; Sun, Baoyun
- Accounts of Chemical Research, Vol. 46, Issue 3
Chemistry and Properties of Nanocrystals of Different Shapes
journal, April 2005
- Burda, Clemens; Chen, Xiaobo; Narayanan, Radha
- Chemical Reviews, Vol. 105, Issue 4
A New Coarse-Grained Force Field for Membrane–Peptide Simulations
journal, October 2011
- Wu, Zhe; Cui, Qiang; Yethiraj, Arun
- Journal of Chemical Theory and Computation, Vol. 7, Issue 11
Correction to Constant pH Molecular Dynamics in Explicit Solvent with λ-Dynamics
journal, June 2013
- Donnini, Serena; Tegeler, Florian; Groenhof, Gerrit
- Journal of Chemical Theory and Computation, Vol. 9, Issue 7
Mechanism of Silver Nanoparticle Toxicity Is Dependent on Dissolved Silver and Surface Coating in Caenorhabditis elegans
journal, December 2011
- Yang, Xinyu; Gondikas, Andreas P.; Marinakos, Stella M.
- Environmental Science & Technology, Vol. 46, Issue 2
Core Structure and Surface Functionalization of Carbon Nanomaterials Alter Impacts to Daphnid Mortality, Reproduction, and Growth: Acute Assays Do Not Predict Chronic Exposure Impacts
journal, July 2013
- Arndt, Devrah A.; Moua, Maika; Chen, Jian
- Environmental Science & Technology, Vol. 47, Issue 16
Enzyme-Directed Assembly of Nanoparticles in Tumors Monitored by in Vivo Whole Animal Imaging and ex Vivo Super-Resolution Fluorescence Imaging
journal, December 2013
- Chien, Miao-Ping; Carlini, Andrea S.; Hu, Dehong
- Journal of the American Chemical Society, Vol. 135, Issue 50
Cationic Au Nanoparticle Binding with Plasma Membrane-like Lipid Bilayers: Potential Mechanism for Spontaneous Permeation to Cells Revealed by Atomistic Simulations
journal, May 2014
- Heikkilä, Elena; Martinez-Seara, Hector; Gurtovenko, Andrey A.
- The Journal of Physical Chemistry C, Vol. 118, Issue 20
Immunotargeted Nanoshells for Integrated Cancer Imaging and Therapy
journal, April 2005
- Loo, Christopher; Lowery, Amanda; Halas, Naomi
- Nano Letters, Vol. 5, Issue 4
Probing Rotational and Translational Diffusion of Nanodoublers in Living Cells on Microsecond Time Scales
journal, April 2014
- Macias-Romero, Carlos; Didier, Marie E. P.; Zubkovs, Vitalijs
- Nano Letters, Vol. 14, Issue 5
Electrical Method to Quantify Nanoparticle Interaction with Lipid Bilayers
journal, January 2013
- Carney, Randy P.; Astier, Yann; Carney, Tamara M.
- ACS Nano, Vol. 7, Issue 2
Emerging Techniques in Proteomics for Probing Nano–Bio Interactions
journal, November 2012
- Lai, Zon W.; Yan, Yan; Caruso, Frank
- ACS Nano, Vol. 6, Issue 12
Simultaneous Single-Particle Superlocalization and Rotational Tracking
journal, January 2013
- Gu, Yan; Wang, Gufeng; Fang, Ning
- ACS Nano, Vol. 7, Issue 2
Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles
journal, May 2014
- Albanese, Alexandre; Walkey, Carl D.; Olsen, Jonathan B.
- ACS Nano, Vol. 8, Issue 6
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics
journal, May 2013
- Zhao, Gongpu; Perilla, Juan R.; Yufenyuy, Ernest L.
- Nature, Vol. 497, Issue 7451
Fast, three-dimensional super-resolution imaging of live cells
journal, May 2011
- Jones, Sara A.; Shim, Sang-Hee; He, Jiang
- Nature Methods, Vol. 8, Issue 6
Nanoparticle therapeutics: an emerging treatment modality for cancer
journal, September 2008
- Davis, Mark E.; Chen, Zhuo; Shin, Dong M.
- Nature Reviews Drug Discovery, Vol. 7, Issue 9
Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies
journal, January 2011
- Khlebtsov, Nikolai; Dykman, Lev
- Chem. Soc. Rev., Vol. 40, Issue 3
Association rule mining of cellular responses induced by metal and metal oxide nanoparticles
journal, January 2014
- Liu, Rong; France, Bryan; George, Saji
- The Analyst, Vol. 139, Issue 5
Perspective on the Martini model
journal, January 2013
- Marrink, Siewert J.; Tieleman, D. Peter
- Chemical Society Reviews, Vol. 42, Issue 16
Molecularly stabilised ultrasmall gold nanoparticles: synthesis, characterization and bioactivity
journal, January 2013
- Leifert, Annika; Pan-Bartnek, Yu; Simon, Ulrich
- Nanoscale, Vol. 5, Issue 14
Global transcriptomic analysis of model human cell lines exposed to surface-modified gold nanoparticles: the effect of surface chemistry
journal, January 2015
- Grzincic, E. M.; Yang, J. A.; Drnevich, J.
- Nanoscale, Vol. 7, Issue 4
Multiple branched adaptive steered molecular dynamics
journal, August 2014
- Ozer, Gungor; Keyes, Thomas; Quirk, Stephen
- The Journal of Chemical Physics, Vol. 141, Issue 6
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
journal, September 2008
- Lundqvist, M.; Stigler, J.; Elia, G.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 38
Nanoparticle-induced surface reconstruction of phospholipid membranes
journal, November 2008
- Wang, B.; Zhang, L.; Bae, S. C.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 47
Equilibrium Sampling in Biomolecular Simulations
journal, June 2011
- Zuckerman, Daniel M.
- Annual Review of Biophysics, Vol. 40, Issue 1
Biomolecular Imaging with Coherent Nonlinear Vibrational Microscopy
journal, April 2013
- Chung, Chao-Yu; Potma, Eric O.
- Annual Review of Physical Chemistry, Vol. 64, Issue 1
Advances in Correlated Electronic Structure Methods for Solids, Surfaces, and Nanostructures
journal, May 2008
- Huang, Patrick; Carter, Emily A.
- Annual Review of Physical Chemistry, Vol. 59, Issue 1
Gold nanoparticles as novel agents for cancer therapy
journal, February 2012
- Jain, S.; Hirst, D. G.; O'Sullivan, J. M.
- The British Journal of Radiology, Vol. 85, Issue 1010
Nano GO Consortium—A Team Science Approach to Assess Engineered Nanomaterials: Reliable Assays and Methods
journal, June 2013
- Schug, Thaddeus T.; Nadadur, Srikanth S.; Johnson, Anne F.
- Environmental Health Perspectives, Vol. 121, Issue 6
NanoMiner — Integrative Human Transcriptomics Data Resource for Nanoparticle Research
journal, July 2013
- Kong, Lingjia; Tuomela, Soile; Hahne, Lauri
- PLoS ONE, Vol. 8, Issue 7
Adsorption of Cellular Proteins to Polyelectrolyte-Functionalized Gold Nanorods: A Mechanism for Nanoparticle Regulation of Cell Phenotype?
journal, February 2014
- Sisco, Patrick N.; Wilson, Christopher G.; Chernak, Davin
- PLoS ONE, Vol. 9, Issue 2
Nanostructure-mediated thermal therapy – the path from bench to clinic
journal, June 2006
- Hauck, Tanya; CW Chan, Warren
- Nanomedicine, Vol. 1, Issue 1
Nanoparticle albumin-bound paclitaxel: a novel Cremphor-EL ® -free formulation of paclitaxel
journal, August 2007
- Stinchcombe, Thomas E.
- Nanomedicine, Vol. 2, Issue 4
Works referencing / citing this record:
Corona Isolation Method Matters: Capillary Electrophoresis Mass Spectrometry Based Comparison of Protein Corona Compositions Following On-Particle versus In-Solution or In-Gel Digestion
journal, June 2019
- Faserl, Klaus; Chetwynd, Andrew J.; Lynch, Iseult
- Nanomaterials, Vol. 9, Issue 6
Recent progress on the development of anisotropic gold nanoparticles: Design strategies and growth mechanism
journal, January 2017
- Jones, Stacy; Pramanik, Avijit; Sweet, Carrie
- Journal of Environmental Science and Health, Part C, Vol. 35, Issue 1
Fifteen years of nanoEHS research advances science and fosters a vibrant community
journal, November 2019
- Friedersdorf, Lisa E.; Bjorkland, Rhema; Klaper, Rebecca D.
- Nature Nanotechnology, Vol. 14, Issue 11
Counting charges on membrane-bound peptides
journal, January 2018
- McGeachy, Alicia C.; Caudill, Emily R.; Liang, Dongyue
- Chemical Science, Vol. 9, Issue 18
Nanoparticles and organized lipid assemblies: from interaction to design of hybrid soft devices
journal, January 2019
- Mendozza, Marco; Caselli, Lucrezia; Salvatore, Annalisa
- Soft Matter, Vol. 15, Issue 44
Metal Telluride Nanomaterials: Facile Synthesis, Properties and Applications for Third Generation Devices.
journal, February 2019
- Jamwal, Deepika; Mehta, Surinder Kumar
- ChemistrySelect, Vol. 4, Issue 6
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
journal, January 2019
- Silva, Catarina Oliveira; Pinho, Jacinta Oliveira; Lopes, Joana Margarida
- Pharmaceutics, Vol. 11, Issue 1
Preferential interactions of primary amine-terminated quantum dots with membrane domain boundaries and lipid rafts revealed with nanometer resolution
journal, January 2020
- Mensch, Arielle C.; Melby, Eric S.; Laudadio, Elizabeth D.
- Environmental Science: Nano, Vol. 7, Issue 1
Supramolecular Self‐Assembly and Organization of Collagen at Solid/Liquid Interface: Effect of Spheroid‐ and Rod‐Shaped TiO 2 Nanocrystals
journal, May 2019
- Beauvais, Mathieu; Degabriel, Thomas; Aissaoui, Nesrine
- Advanced Materials Interfaces, Vol. 6, Issue 14
QM/MM free energy simulations: recent progress and challenges
journal, July 2016
- Lu, Xiya; Fang, Dong; Ito, Shingo
- Molecular Simulation, Vol. 42, Issue 13
Biofabrication of Cubic Phase Silver Nanoparticles Loaded with Phytochemicals from Solanum nigrum Leaf Extracts for Potential Antibacterial, Antibiofilm and Antioxidant Activities Against MDR Human Pathogens
journal, November 2016
- Jinu, U.; Jayalakshmi, N.; Sujima Anbu, A.
- Journal of Cluster Science, Vol. 28, Issue 1
Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design
journal, February 2019
- Singh, Ajay Vikram; Laux, Peter; Luch, Andreas
- Toxicology Mechanisms and Methods, Vol. 29, Issue 5
Molecular engineering solutions for therapeutic peptide delivery
journal, January 2017
- Acar, Handan; Ting, Jeffrey M.; Srivastava, Samanvaya
- Chemical Society Reviews, Vol. 46, Issue 21
Gold nanoparticles with patterned surface monolayers for nanomedicine: current perspectives
journal, September 2017
- Pengo, Paolo; Şologan, Maria; Pasquato, Lucia
- European Biophysics Journal, Vol. 46, Issue 8
Imaging Flow Cytometry Assays for Quantifying Pigment Grade Titanium Dioxide Particle Internalisation and Interactions with Immune Cells in Whole Blood.
journalarticle, January 2017
- Hewitt, Re; Vis, B.; Pele, Lc
- Wiley
Organoid Technology: A Reliable Developmental Biology Tool for Organ-Specific Nanotoxicity Evaluation
journal, September 2021
- Prasad, Minakshi; Kumar, Rajesh; Buragohain, Lukumoni
- Frontiers in Cell and Developmental Biology, Vol. 9
Designing Dendrimer and Miktoarm Polymer Based Multi-Tasking Nanocarriers for Efficient Medical Therapy
journal, September 2015
- Sharma, Anjali; Kakkar, Ashok
- Molecules, Vol. 20, Issue 9
Corona Isolation Method Matters: Capillary Electrophoresis Mass Spectrometry Based Comparison of Protein Corona Compositions Following On-Particle versus In-Solution or In-Gel Digestion
journal, June 2019
- Faserl, Klaus; Chetwynd, Andrew J.; Lynch, Iseult
- Nanomaterials, Vol. 9, Issue 6
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
journal, January 2019
- Silva, Catarina Oliveira; Pinho, Jacinta Oliveira; Lopes, Joana Margarida
- Pharmaceutics, Vol. 11, Issue 1