Design of experiments and data analysis challenges in calibration for forensics applications
Abstract
Forensic science aims to infer characteristics of source terms using measured observables. Our focus is on statistical design of experiments and data analysis challenges arising in nuclear forensics. More specifically, we focus on inferring aspects of experimental conditions (of a process to produce product Pu oxide powder), such as temperature, nitric acid concentration, and Pu concentration, using measured features of the product Pu oxide powder. The measured features, Y, include trace chemical concentrations and particle morphology such as particle size and shape of the produced Pu oxide power particles. Making inferences about the nature of inputs X that were used to create nuclear materials having particular characteristics, Y, is an inverse problem. Therefore, statistical analysis can be used to identify the best set (or sets) of Xs for a new set of observed responses Y. One can fit a model (or models) such as Υ = f(Χ) + error, for each of the responses, based on a calibration experiment and then “invert” to solve for the best set of Xs for a new set of Ys. This perspectives paper uses archived experimental data to consider aspects of data collection and experiment design for the calibration data to maximize the qualitymore »
- Authors:
-
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1221551
- Report Number(s):
- LA-UR-15-22677
Journal ID: ISSN 0169-7439; TRN: US1600507
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Chemometrics and Intelligent Laboratory Systems
- Additional Journal Information:
- Journal Volume: 149; Journal Issue: PB; Journal ID: ISSN 0169-7439
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 97 MATHEMATICS AND COMPUTING; design of experiments; measurement error; multivariate calibration; nuclear forensics
Citation Formats
Anderson-Cook, Christine M., Burr, Thomas L., Hamada, Michael S., Ruggiero, Christy E., and Thomas, Edward V.. Design of experiments and data analysis challenges in calibration for forensics applications. United States: N. p., 2015.
Web. doi:10.1016/j.chemolab.2015.07.008.
Anderson-Cook, Christine M., Burr, Thomas L., Hamada, Michael S., Ruggiero, Christy E., & Thomas, Edward V.. Design of experiments and data analysis challenges in calibration for forensics applications. United States. https://doi.org/10.1016/j.chemolab.2015.07.008
Anderson-Cook, Christine M., Burr, Thomas L., Hamada, Michael S., Ruggiero, Christy E., and Thomas, Edward V.. Wed .
"Design of experiments and data analysis challenges in calibration for forensics applications". United States. https://doi.org/10.1016/j.chemolab.2015.07.008. https://www.osti.gov/servlets/purl/1221551.
@article{osti_1221551,
title = {Design of experiments and data analysis challenges in calibration for forensics applications},
author = {Anderson-Cook, Christine M. and Burr, Thomas L. and Hamada, Michael S. and Ruggiero, Christy E. and Thomas, Edward V.},
abstractNote = {Forensic science aims to infer characteristics of source terms using measured observables. Our focus is on statistical design of experiments and data analysis challenges arising in nuclear forensics. More specifically, we focus on inferring aspects of experimental conditions (of a process to produce product Pu oxide powder), such as temperature, nitric acid concentration, and Pu concentration, using measured features of the product Pu oxide powder. The measured features, Y, include trace chemical concentrations and particle morphology such as particle size and shape of the produced Pu oxide power particles. Making inferences about the nature of inputs X that were used to create nuclear materials having particular characteristics, Y, is an inverse problem. Therefore, statistical analysis can be used to identify the best set (or sets) of Xs for a new set of observed responses Y. One can fit a model (or models) such as Υ = f(Χ) + error, for each of the responses, based on a calibration experiment and then “invert” to solve for the best set of Xs for a new set of Ys. This perspectives paper uses archived experimental data to consider aspects of data collection and experiment design for the calibration data to maximize the quality of the predicted Ys in the forward models; that is, we assume that well-estimated forward models are effective in the inverse problem. In addition, we consider how to identify a best solution for the inferred X, and evaluate the quality of the result and its robustness to a variety of initial assumptions, and different correlation structures between the responses. In addition, we also briefly review recent advances in metrology issues related to characterizing particle morphology measurements used in the response vector, Y.},
doi = {10.1016/j.chemolab.2015.07.008},
journal = {Chemometrics and Intelligent Laboratory Systems},
number = PB,
volume = 149,
place = {United States},
year = {Wed Jul 15 00:00:00 EDT 2015},
month = {Wed Jul 15 00:00:00 EDT 2015}
}
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