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Title: The significance of macrophage phenotype in cancer and biomaterials

Macrophages have long been known to exhibit heterogeneous and plastic phenotypes. They show functional diversity with roles in homeostasis, tissue repair, immunity and disease. There exists a spectrum of macrophage phenotypes with varied effector functions, molecular determinants, cytokine and chemokine profiles, as well as receptor expression. In tumor microenvironments, the subset of macrophages known as tumor-associated macrophages generates byproducts that enhance tumor growth and angiogenesis, making them attractive targets for anti-cancer therapeutics. With respect to wound healing and the foreign body response, there is a necessity for balance between pro-inflammatory, wound healing, and regulatory macrophages in order to achieve successful implantation of a scaffold for tissue engineering. In this review, we discuss the multitude of ways macrophages are known to be important in cancer therapies and implanted biomaterials.
Authors:
 [1] ;  [1] ;  [2]
  1. Iowa State Univ., Ames, IA (United States)
  2. Iowa State Univ., Ames, IA (United States); Ames National Laboratory, Ames IA (United States)
Publication Date:
OSTI Identifier:
1214820
Grant/Contract Number:
W-7405-ENG-82
Type:
Accepted Manuscript
Journal Name:
Clinical and Translational Medicine (Online)
Additional Journal Information:
Journal Name: Clinical and Translational Medicine (Online); Journal Volume: 3; Journal Issue: 1; Journal ID: ISSN 2001-1326
Publisher:
Springer
Research Org:
Ames Laboratory (AMES), Ames, IA (United States)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES macrophage reprogramming; cancer; biomaterials; anti-angiogenic therapy; recruitment inhibition; tissue engineering; foreign body response