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Title: A trinuclear oxo-chromium(III) complex containing the natural flavonoid primuletin: Synthesis, characterization, and antiradical properties

A new trinuclear oxo-centered chromium(III) complex with formula [Cr₃O(CH₃CO₂)₆(L)(H₂O)₂] (L = 5-hydroxyflavone, known as primuletin) was synthetized and characterized by ESI mass spectrometry, thermogravimetry, and ¹H-NMR, UV-Vis, and FTIR spectroscopies. In agreement with the experimental results, DFT calculations indicated that the flavonoid ligand is coordinated to one of the three Cr(III) centers in an O,O-bidentate mode through the 5-hydroxy/4-keto groups. In a comparative study involving the uncoordinated primuletin and its corresponding complex, systematic reactions with the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that antiradical activity increases upon complexation.
Authors:
 [1] ;  [2] ;  [2] ;  [2] ;  [3] ;  [2]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Univ. Presbiteriana Mackenzie, Sao Paulo (Brazil)
  3. Univ. de Sao Paulo, Sao Paulo (Brazil)
Publication Date:
OSTI Identifier:
1208875
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Molecules
Additional Journal Information:
Journal Volume: 20; Journal Issue: 4; Journal ID: ISSN 1420-3049
Publisher:
MDPI
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY antiradical activity; chromium(III) complexes; flavonoids; metal-oxo cluster; primuletin