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Title: Production of ⁶¹Cu by the natZn(p,α) reaction: Improved separation and specific activity determination by titration with three chelators

In this study, the cyclotron-based production of position-emitting ⁶¹Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched ⁶⁴Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate ⁶¹Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified ⁶¹Cu determined using ICP-MS analysis ranged from 143.3±14.3(SD) to 506.2±50.6 MBq/μg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7±0.2 to 412.5±15.3 MBq/μg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.
Authors:
 [1] ;  [2] ;  [3] ;  [3] ;  [3] ;  [4]
  1. Sir Charles Gairdner Hospital, Perth (Western Australia); Curtin Univ., Perth (Western Australia)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States)
  3. Sir Charles Gairdner Hospital, Perth (Western Australia)
  4. Sir Charles Gairdner Hospital, Perth (Western Australia); Univ. of Western Australia, Nedland (Western Australia)
Publication Date:
OSTI Identifier:
1201367
Report Number(s):
BNL--108191-2015-JA
Journal ID: ISSN 0236-5731; R&D Project: KBCH139; 00600; KB0202011
Grant/Contract Number:
SC00112704
Type:
Accepted Manuscript
Journal Name:
Journal of Radioanalytical and Nuclear Chemistry
Additional Journal Information:
Journal Volume: 6; Journal Issue: 8; Journal ID: ISSN 0236-5731
Publisher:
Springer
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY ⁶¹Cu; natZn; ⁶⁴Zn; specific activity; ICP-MS; bifunctional chelators