Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis
Abstract
The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of cerium oxide nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of cerium oxide nanoparticle demonstrate that concentration of cerium oxide nanoparticles below 1 mg/ml did not significantly influence cell survival as determined by the MTT assay.
- Authors:
- Publication Date:
- Research Org.:
- Marshall Univ., Huntington, WV (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1198693
- Alternate Identifier(s):
- OSTI ID: 1629799
- Grant/Contract Number:
- PS02-09ER-01; SC0008104
- Resource Type:
- Published Article
- Journal Name:
- Data in Brief
- Additional Journal Information:
- Journal Name: Data in Brief Journal Volume: 4 Journal Issue: C; Journal ID: ISSN 2352-3409
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Sepsis; LPS; Sprague Dawley rat; MTT; Raw 264.7; Cerium oxide nanoparticles
Citation Formats
Selvaraj, Vellaisamy, Nepal, Niraj, Rogers, Steven, Manne, Nandini D. P. K., Arvapalli, Ravikumar, Rice, Kevin M., Asano, Shinichi, Fankenhanel, Erin, Ma, J. Y., Shokuhfar, Tolou, Maheshwari, Mani, and Blough, Eric R. Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis. United States: N. p., 2015.
Web. doi:10.1016/j.dib.2015.04.023.
Selvaraj, Vellaisamy, Nepal, Niraj, Rogers, Steven, Manne, Nandini D. P. K., Arvapalli, Ravikumar, Rice, Kevin M., Asano, Shinichi, Fankenhanel, Erin, Ma, J. Y., Shokuhfar, Tolou, Maheshwari, Mani, & Blough, Eric R. Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis. United States. https://doi.org/10.1016/j.dib.2015.04.023
Selvaraj, Vellaisamy, Nepal, Niraj, Rogers, Steven, Manne, Nandini D. P. K., Arvapalli, Ravikumar, Rice, Kevin M., Asano, Shinichi, Fankenhanel, Erin, Ma, J. Y., Shokuhfar, Tolou, Maheshwari, Mani, and Blough, Eric R. Tue .
"Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis". United States. https://doi.org/10.1016/j.dib.2015.04.023.
@article{osti_1198693,
title = {Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis},
author = {Selvaraj, Vellaisamy and Nepal, Niraj and Rogers, Steven and Manne, Nandini D. P. K. and Arvapalli, Ravikumar and Rice, Kevin M. and Asano, Shinichi and Fankenhanel, Erin and Ma, J. Y. and Shokuhfar, Tolou and Maheshwari, Mani and Blough, Eric R.},
abstractNote = {The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of cerium oxide nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of cerium oxide nanoparticle demonstrate that concentration of cerium oxide nanoparticles below 1 mg/ml did not significantly influence cell survival as determined by the MTT assay.},
doi = {10.1016/j.dib.2015.04.023},
journal = {Data in Brief},
number = C,
volume = 4,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 2015},
month = {Tue Sep 01 00:00:00 EDT 2015}
}
https://doi.org/10.1016/j.dib.2015.04.023