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Title: Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network

The spatial correlations between the brain's default mode network (DMN) and the brain regions known to develop pathophysiology in Alzheimer's disease (AD) have recently attracted much attention. In this paper, we compare results of different functional and structural imaging modalities, including MRI and PET, and highlight different patterns of anomalies observed within the DMN. Multitracer PET imaging in subjects with and without dementia has demonstrated that [C-11]PIB- and [F-18]FDDNP-binding patterns in patients with AD overlap within nodes of the brain's default network including the prefrontal, lateral parietal, lateral temporal, and posterior cingulate cortices, with the exception of the medial temporal cortex (especially, the hippocampus) where significant discrepancy between increased [F-18]FDDNP binding and negligible [C-11]PIB-binding was observed. [F-18]FDDNP binding in the medial temporal cortex—a key constituent of the DMN—coincides with both the presence of amyloid and tau pathology, and also with cortical areas with maximal atrophy as demonstrated by T1-weighted MR imaging of AD patients.
Authors:
 [1] ;  [2] ;  [3] ;  [2] ;  [2]
  1. Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon 405-760, Republic of Korea, Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, The University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095-6948, USA, Department of Molecular and Medical Pharmacology, The University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095-6948, USA
  2. Department of Molecular and Medical Pharmacology, The University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095-6948, USA
  3. Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, The University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095-6948, USA
Publication Date:
OSTI Identifier:
1198463
Grant/Contract Number:
FC03-87-ER60615
Type:
Published Article
Journal Name:
International Journal of Alzheimer's Disease
Additional Journal Information:
Journal Volume: 2011; Related Information: CHORUS Timestamp: 2016-08-04 13:47:03; Journal ID: ISSN 2090-0252
Publisher:
Hindawi Publishing Corporation
Sponsoring Org:
USDOE
Country of Publication:
Country unknown/Code not available
Language:
English