Structural Formation of Huntingtin Exon 1 Aggregates Probed by Small-Angle Neutron Scattering

Stanley, Christopher B.; Perevozchikova, Tatiana; Berthelier, Valerie

doi:10.1016/j.bpj.2011.04.022

Title: Structural Formation of Huntingtin Exon 1 Aggregates Probed by Small-Angle Neutron Scattering

Authors:: Stanley, Christopher B.; Perevozchikova, Tatiana; Berthelier, Valerie

Publication Date:: Sun May 01 00:00:00 EDT 2011

Sponsoring Org.:: USDOE

OSTI Identifier:: 1198423

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Published Article

Journal Name:: Biophysical Journal

Additional Journal Information:: Journal Name: Biophysical Journal Journal Volume: 100 Journal Issue: 10; Journal ID: ISSN 0006-3495

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Citation Formats


                    Stanley, Christopher B., Perevozchikova, Tatiana, and Berthelier, Valerie. Structural Formation of Huntingtin Exon 1 Aggregates Probed by Small-Angle Neutron Scattering.  United States: N. p., 2011. 
Web.  doi:10.1016/j.bpj.2011.04.022.

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                    Stanley, Christopher B., Perevozchikova, Tatiana, & Berthelier, Valerie. Structural Formation of Huntingtin Exon 1 Aggregates Probed by Small-Angle Neutron Scattering.  United States.  https://doi.org/10.1016/j.bpj.2011.04.022

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                    Stanley, Christopher B., Perevozchikova, Tatiana, and Berthelier, Valerie. Sun .  
"Structural Formation of Huntingtin Exon 1 Aggregates Probed by Small-Angle Neutron Scattering".  United States.  https://doi.org/10.1016/j.bpj.2011.04.022.

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@article{osti_1198423,

  title        = {Structural Formation of Huntingtin Exon 1 Aggregates Probed by Small-Angle Neutron Scattering},

  author       = {Stanley, Christopher B. and Perevozchikova, Tatiana and Berthelier, Valerie},

  abstractNote = {},

  doi          = {10.1016/j.bpj.2011.04.022},

  journal      = {Biophysical Journal},

  number       = 10,

  volume       = 100,

  place        = {United States},

  year         = {Sun May 01 00:00:00 EDT 2011},

  month        = {Sun May 01 00:00:00 EDT 2011}

}

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Similar Records

Title: Structural Formation of Huntingtin Exon 1 Aggregates Probed by Small-Angle Neutron Scattering

Citation Formats

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo journal, May 2010

Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool journal, July 2010

Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts journal, November 2005

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Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism journal, March 2009

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Secondary Structure of Huntingtin Amino-Terminal Region journal, September 2009

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity journal, August 2001

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CRYSOL – a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates journal, December 1995

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A Two-Step Path to Inclusion Formation of Huntingtin Peptides Revealed by Number and Brightness Analysis journal, June 2010

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Atomic structures of amyloid cross-β spines reveal varied steric zippers journal, April 2007

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Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin journal, June 2006

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Polyglutamine diseases: emerging concepts in pathogenesis and therapy journal, July 2007

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer journal, November 2004

Protein Misfolding, Functional Amyloid, and Human Disease journal, June 2006

Solution Structure of an Amyloid-Forming Protein During Photoinitiated Hexamer−Dodecamer Transitions Revealed through Small-Angle Neutron Scattering journal, June 2007

Aggregation of β-lactoglobulin and influence of D 2 O journal, January 1998

Polyglutamine homopolymers having 8-45 residues form slablike β-crystallite assemblies journal, August 2005

Huntingtin aggregates may not predict neuronal death in Huntington's disease journal, December 1999

On volume changes accompanying conformational transitions of biopolymers journal, November 1996

Huntingtin Spheroids and Protofibrils as Precursors in Polyglutamine Fibrilization journal, October 2002

Reassessing random-coil statistics in unfolded proteins journal, August 2004

Amyloid fibers are water-filled nanotubes journal, April 2002

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid -peptide of amyloid plaques journal, April 2002

Analysis of small-angle scattering data from colloids and polymer solutions: modeling and least-squares fitting journal, July 1997

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo
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Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool
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Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts
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Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
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A universal pathway for amyloid nucleus and precursor formation for insulin
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Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism
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New Model for Crystalline Polyglutamine Assemblies and Their Connection with Amyloid Fibrils
journal, December 2004

Secondary Structure of Huntingtin Amino-Terminal Region
journal, September 2009

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity
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A Helical Structural Nucleus Is the Primary Elongating Unit of Insulin Amyloid Fibrils
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CRYSOL – a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates
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A Two-Step Path to Inclusion Formation of Huntingtin Peptides Revealed by Number and Brightness Analysis
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Atomic structures of amyloid cross-β spines reveal varied steric zippers
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Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils
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Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions
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Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin
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Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington's disease pathology
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Polyglutamine diseases: emerging concepts in pathogenesis and therapy
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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer
journal, November 2004

Protein Misfolding, Functional Amyloid, and Human Disease
journal, June 2006

Solution Structure of an Amyloid-Forming Protein During Photoinitiated Hexamer−Dodecamer Transitions Revealed through Small-Angle Neutron Scattering
journal, June 2007

Aggregation of β-lactoglobulin and influence of D ₂ O
journal, January 1998

Polyglutamine homopolymers having 8-45 residues form slablike β-crystallite assemblies
journal, August 2005

Huntingtin aggregates may not predict neuronal death in Huntington's disease
journal, December 1999

On volume changes accompanying conformational transitions of biopolymers
journal, November 1996

Huntingtin Spheroids and Protofibrils as Precursors in Polyglutamine Fibrilization
journal, October 2002

Reassessing random-coil statistics in unfolded proteins
journal, August 2004

Amyloid fibers are water-filled nanotubes
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Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid -peptide of amyloid plaques
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Analysis of small-angle scattering data from colloids and polymer solutions: modeling and least-squares fitting
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