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Title: Heterosis: Many Genes, Many Mechanisms—End the Search for an Undiscovered Unifying Theory

Heterosis is the increase in vigor that is observed in progenies of matings of diverse individuals from different species, isolated populations, or selected strains within species or populations. Heterosis has been of immense economic value in agriculture and has important implications regarding the fitness and fecundity of individuals in natural populations. Genetic models based on complementation of deleterious alleles, especially in the context of linkage and epistasis, are consistent with many observed manifestations of heterosis. The search for the genes and alleles that underlie heterosis, as well as for broader allele-independent, genomewide mechanisms, has encompassed many species and systems. Common themes across these studies indicate that sequence diversity is necessary but not sufficient to produce heterotic phenotypes, and that the molecular pathways that produce heterosis involve chromatin modification, transcriptional control, translation and protein processing, and interactions between and within developmental and biochemical pathways. Taken together, there are many and diverse molecular mechanisms that translate DNA into phenotype, and it is the combination of all these mechanisms across many genes that produce heterosis in complex traits.
Authors:
 [1]
  1. Department of Agronomy, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
Publication Date:
OSTI Identifier:
1198322
Grant/Contract Number:
FC02-07ER64494
Type:
Published Article
Journal Name:
ISRN Botany
Additional Journal Information:
Journal Volume: 2012; Related Information: CHORUS Timestamp: 2016-08-02 16:51:38; Journal ID: ISSN 2090-8598
Publisher:
Hindawi (International Scholarly Research Network)
Sponsoring Org:
USDOE
Country of Publication:
Country unknown/Code not available
Language:
English