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Title: Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture

Osteoporosis can profoundly affect the aged as a consequence of progressive bone loss; high-dose ionizing radiation can cause similar changes, although less is known about lower doses (≤100 cGy). We hypothesized that exposure to relatively low doses of gamma radiation accelerates structural changes characteristic of skeletal aging. Mice (C57BL/6J-10 wk old, male) were irradiated (total body; 0-sham, 1, 10 or 100 cGy 137 Cs) and tissues harvested on the day of irradiation, 1 or 4 months later. Microcomputed tomography was used to quantify microarchitecture of high turnover, cancellous bone. Irradiation at 100 cGy caused transient microarchitectural changes over one month that were only evident at longer times in controls (4 months). Ex vivo bone cell differentiation from the marrow was unaffected by gamma radiation. In conclusion, acute ionizing gamma irradiation at 100 cGy (but not at 1 cGy or 10 cGy) exacerbated microarchitectural changes normally found during progressive, postpubertal aging prior to the onset of age-related osteoporosis.
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [2] ;  [1]
  1. Bone and Signaling Laboratory, NASA Ames Research Center, Mail Stop 236-7, Moffett Field, CA 94035, USA
  2. Department of Radiation Oncology, University of California Irvine, Irvine, CA 92697, USA
Publication Date:
OSTI Identifier:
1198309
Grant/Contract Number:
SC0001507
Type:
Published Article
Journal Name:
Journal of Aging Research
Additional Journal Information:
Journal Volume: 2012; Related Information: CHORUS Timestamp: 2016-08-02 16:03:06; Journal ID: ISSN 2090-2204
Publisher:
Hindawi Publishing Corporation
Sponsoring Org:
USDOE
Country of Publication:
Country unknown/Code not available
Language:
English