Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention

Lim, I-Im S.; Wang, Lingyan; Chandrachud, Uma; Gal, Susannah; Zhong, Chuan-Jian

doi:10.1155/2008/527294

Title: Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention

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Abstract

This report describes the viability of a strategy for manipulating the assembly/disassembly processes of DNA-Au nanoparticles by molecular intervention. Using the temperature-induced assembly and disassembly processes of DNAs and gold nanoparticles as a model system, the introduction of a molecular recognition probe is demonstrated to lead to the intervention of the assembly/disassembly processes depending on its specific biorecognition. This process can be detected by monitoring the change in the optical properties of gold nanoparticles and their DNA assemblies. Implications of the preliminary results to exploration of the resulting nanostructures for fine-tuning of the interfacial reactivities in DNA-based bioassays and biomaterial engineering are also discussed.

Authors:

Lim, I-Im S. ^[1]; Wang, Lingyan ^[1]; Chandrachud, Uma ^[2]; Gal, Susannah ^[2]; Zhong, Chuan-Jian ^[1]

Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902-6000, USA
Department of Biological Sciences, State University of New York at Binghamton, Binghamton, NY 13902-6000, USA

Publication Date:: Tue Jan 01 00:00:00 EST 2008

Sponsoring Org.:: USDOE

OSTI Identifier:: 1198270

Grant/Contract Number:: FG02-06ER64281

Resource Type:: Published Article

Journal Name:: Research Letters in Nanotechnology

Additional Journal Information:: Journal Name: Research Letters in Nanotechnology Journal Volume: 2008; Journal ID: ISSN 1687-6849

Publisher:: Hindawi Publishing Corporation

Country of Publication:: Country unknown/Code not available

Language:: English

Citation Formats


                    Lim, I-Im S., Wang, Lingyan, Chandrachud, Uma, Gal, Susannah, and Zhong, Chuan-Jian. Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention.  Country unknown/Code not available: N. p., 2008. 
Web.  doi:10.1155/2008/527294.

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                    Lim, I-Im S., Wang, Lingyan, Chandrachud, Uma, Gal, Susannah, & Zhong, Chuan-Jian. Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention.  Country unknown/Code not available.  https://doi.org/10.1155/2008/527294

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                    Lim, I-Im S., Wang, Lingyan, Chandrachud, Uma, Gal, Susannah, and Zhong, Chuan-Jian. Tue .  
"Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention".  Country unknown/Code not available.  https://doi.org/10.1155/2008/527294.

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@article{osti_1198270,

  title        = {Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention},

  author       = {Lim, I-Im S. and Wang, Lingyan and Chandrachud, Uma and Gal, Susannah and Zhong, Chuan-Jian},

  abstractNote = {This report describes the viability of a strategy for manipulating the assembly/disassembly processes of DNA-Au nanoparticles by molecular intervention. Using the temperature-induced assembly and disassembly processes of DNAs and gold nanoparticles as a model system, the introduction of a molecular recognition probe is demonstrated to lead to the intervention of the assembly/disassembly processes depending on its specific biorecognition. This process can be detected by monitoring the change in the optical properties of gold nanoparticles and their DNA assemblies. Implications of the preliminary results to exploration of the resulting nanostructures for fine-tuning of the interfacial reactivities in DNA-based bioassays and biomaterial engineering are also discussed.},

  doi          = {10.1155/2008/527294},

  journal      = {Research Letters in Nanotechnology},

  number       = ,

  volume       = 2008,

  place        = {Country unknown/Code not available},

  year         = {Tue Jan 01 00:00:00 EST 2008},

  month        = {Tue Jan 01 00:00:00 EST 2008}

}

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