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Title: Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention

This report describes the viability of a strategy for manipulating the assembly/disassembly processes of DNA-Au nanoparticles by molecular intervention. Using the temperature-induced assembly and disassembly processes of DNAs and gold nanoparticles as a model system, the introduction of a molecular recognition probe is demonstrated to lead to the intervention of the assembly/disassembly processes depending on its specific biorecognition. This process can be detected by monitoring the change in the optical properties of gold nanoparticles and their DNA assemblies. Implications of the preliminary results to exploration of the resulting nanostructures for fine-tuning of the interfacial reactivities in DNA-based bioassays and biomaterial engineering are also discussed.
Authors:
 [1] ;  [1] ;  [2] ;  [2] ;  [1]
  1. Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902-6000, USA
  2. Department of Biological Sciences, State University of New York at Binghamton, Binghamton, NY 13902-6000, USA
Publication Date:
OSTI Identifier:
1198270
Grant/Contract Number:
FG02-06ER64281
Type:
Published Article
Journal Name:
Research Letters in Nanotechnology
Additional Journal Information:
Journal Volume: 2008; Related Information: CHORUS Timestamp: 2016-08-11 10:37:05; Journal ID: ISSN 1687-6849
Publisher:
Hindawi Publishing Corporation
Sponsoring Org:
USDOE
Country of Publication:
Country unknown/Code not available
Language:
English