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Title: A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood

Multiple interacting mechanisms control the formation and dissolution of clots to maintain blood in a state of delicate balance. In addition to a myriad of biochemical reactions, rheological factors also play a crucial role in modulating the response of blood to external stimuli. To date, a comprehensive model for clot formation and dissolution, that takes into account the biochemical, medical and rheological factors, has not been put into place, the existing models emphasizing either one or the other of the factors. In this paper, after discussing the various biochemical, physiologic and rheological factors at some length, we develop a model for clot formation and dissolution that incorporates many of the relevant crucial factors that have a bearing on the problem. The model, though just a first step towards understanding a complex phenomenon, goes further than previous models in integrating the biochemical, physiologic and rheological factors that come into play.
Authors:
 [1] ;  [2] ;  [1]
  1. Department of Mechanical Engineering, Texas A & M University, College Station, TX 77843, USA
  2. Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Publication Date:
OSTI Identifier:
1198219
Type:
Published Article
Journal Name:
Journal of Theoretical Medicine
Additional Journal Information:
Journal Volume: 5; Journal Issue: 3-4; Related Information: CHORUS Timestamp: 2016-08-23 11:49:50; Journal ID: ISSN 1027-3662
Publisher:
Hindawi Publishing Corporation
Sponsoring Org:
USDOE
Country of Publication:
Country unknown/Code not available
Language:
English