Isolating Toxic Insulin Amyloid Reactive Species that Lack β-Sheets and Have Wide pH Stability
- Authors:
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1197746
- Grant/Contract Number:
- FE02-90ER14114; FE02-001ER46429
- Resource Type:
- Published Article
- Journal Name:
- Biophysical Journal
- Additional Journal Information:
- Journal Name: Biophysical Journal Journal Volume: 100 Journal Issue: 11; Journal ID: ISSN 0006-3495
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Heldt, Caryn L., Kurouski, Dmitry, Sorci, Mirco, Grafeld, Elizabeth, Lednev, Igor K., and Belfort, Georges. Isolating Toxic Insulin Amyloid Reactive Species that Lack β-Sheets and Have Wide pH Stability. United States: N. p., 2011.
Web. doi:10.1016/j.bpj.2011.04.046.
Heldt, Caryn L., Kurouski, Dmitry, Sorci, Mirco, Grafeld, Elizabeth, Lednev, Igor K., & Belfort, Georges. Isolating Toxic Insulin Amyloid Reactive Species that Lack β-Sheets and Have Wide pH Stability. United States. https://doi.org/10.1016/j.bpj.2011.04.046
Heldt, Caryn L., Kurouski, Dmitry, Sorci, Mirco, Grafeld, Elizabeth, Lednev, Igor K., and Belfort, Georges. Wed .
"Isolating Toxic Insulin Amyloid Reactive Species that Lack β-Sheets and Have Wide pH Stability". United States. https://doi.org/10.1016/j.bpj.2011.04.046.
@article{osti_1197746,
title = {Isolating Toxic Insulin Amyloid Reactive Species that Lack β-Sheets and Have Wide pH Stability},
author = {Heldt, Caryn L. and Kurouski, Dmitry and Sorci, Mirco and Grafeld, Elizabeth and Lednev, Igor K. and Belfort, Georges},
abstractNote = {},
doi = {10.1016/j.bpj.2011.04.046},
journal = {Biophysical Journal},
number = 11,
volume = 100,
place = {United States},
year = {Wed Jun 01 00:00:00 EDT 2011},
month = {Wed Jun 01 00:00:00 EDT 2011}
}
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https://doi.org/10.1016/j.bpj.2011.04.046
https://doi.org/10.1016/j.bpj.2011.04.046
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Cited by: 17 works
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Works referenced in this record:
Metal Deficiency Increases Aberrant Hydrophobicity of Mutant Superoxide Dismutases That Cause Amyotrophic Lateral Sclerosis
journal, October 2009
- Tiwari, Ashutosh; Liba, Amir; Sohn, Se Hui
- Journal of Biological Chemistry, Vol. 284, Issue 40
Conformational dynamics of insulin in solution. Circular dichroic studies
journal, October 1980
- Pocker, Y.; Biswas, Subhasis B.
- Biochemistry, Vol. 19, Issue 22
The Free-Energy Landscape of Clusters of Attractive Hard Spheres
journal, January 2010
- Meng, G.; Arkus, N.; Brenner, M. P.
- Science, Vol. 327, Issue 5965
Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers
journal, July 2010
- Ladiwala, Ali Reza A.; Lin, Jason C.; Bale, Shyam Sundhar
- Journal of Biological Chemistry, Vol. 285, Issue 31
Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy
journal, January 2000
- Bouchard, Mario; Zurdo, Jesús; Nettleton, Ewan J.
- Protein Science, Vol. 9, Issue 10
Charge Distribution and Amyloid Fibril Formation: Insights from Genetically Engineered Model Systems
journal, July 2010
- Topilina, Natalya I.; Sikirzhytsky, Vitali; Higashiya, Seiichiro
- Biomacromolecules, Vol. 11, Issue 7
Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta
journal, March 2009
- Pigino, G.; Morfini, G.; Atagi, Y.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 14
A universal pathway for amyloid nucleus and precursor formation for insulin
journal, February 2009
- Nayak, Arpan; Sorci, Mirco; Krueger, Susan
- Proteins: Structure, Function, and Bioinformatics, Vol. 74, Issue 3
An Analytical Solution to the Kinetics of Breakable Filament Assembly
journal, December 2009
- Knowles, T. P. J.; Waudby, C. A.; Devlin, G. L.
- Science, Vol. 326, Issue 5959
A Helical Structural Nucleus Is the Primary Elongating Unit of Insulin Amyloid Fibrils
journal, May 2007
- Vestergaard, Bente; Groenning, Minna; Roessle, Manfred
- PLoS Biology, Vol. 5, Issue 5
Lability Landscape and Protease Resistance of Human Insulin Amyloid: A New Insight into Its Molecular Properties
journal, February 2010
- Malisauskas, Mantas; Weise, Christoph; Yanamandra, Kiran
- Journal of Molecular Biology, Vol. 396, Issue 1
Deep-UV Raman spectrometer tunable between 193 and 205�nm for structural characterization of proteins
journal, December 2004
- Lednev, Igor K.; Ermolenkov, Vladimir V.; He, Wei
- Analytical and Bioanalytical Chemistry, Vol. 381, Issue 2
Insulin containing polyethylenimine–dextran sulfate nanoparticles
journal, April 2003
- Tiyaboonchai, Waree; Woiszwillo, James; Sims, Robert C.
- International Journal of Pharmaceutics, Vol. 255, Issue 1-2
Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
journal, June 2009
- Maji, S. K.; Perrin, M. H.; Sawaya, M. R.
- Science, Vol. 325, Issue 5938
Formation and dissolution of hen egg white lysozyme amyloid fibrils in protic ionic liquids
journal, January 2009
- Byrne, Nolene; Angell, C. Austen
- Chemical Communications, Issue 9
Effect of Surface Wettability on the Adhesion of Proteins
journal, August 2004
- Sethuraman, Ananthakrishnan; Han, Mina; Kane, Ravi S.
- Langmuir, Vol. 20, Issue 18
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
journal, April 2003
- Kayed, R.
- Science, Vol. 300, Issue 5618
Quantitative methods for structural characterization of proteins based on deep UV resonance Raman spectroscopy
journal, September 2010
- Shashilov, Victor A.; Sikirzhytski, Vitali; Popova, Ludmila A.
- Methods, Vol. 52, Issue 1
Guanidine Hydrochloride Can Induce Amyloid Fibril Formation from Hen Egg-White Lysozyme
journal, June 2004
- Vernaglia, Brian A.; Huang, Jia; Clark, Eliana D.
- Biomacromolecules, Vol. 5, Issue 4
DMSO-Related Effects in Protein Characterization
journal, December 2005
- Tjernberg, Agneta; Markova, Natalia; Griffiths, William J.
- Journal of Biomolecular Screening, Vol. 11, Issue 2
Steroid Hormones Block Amyloid Fibril-Induced 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) Formazan Exocytosis: Relationship to Neurotoxicity
journal, December 1998
- Liu, Yuanbin; Schubert, David
- Journal of Neurochemistry, Vol. 71, Issue 6
Structural Characterization of a Soluble Amyloid β-Peptide Oligomer
journal, March 2009
- Yu, Liping; Edalji, Rohinton; Harlan, John E.
- Biochemistry, Vol. 48, Issue 9
Amyloid Fibrils of Mammalian Prion Protein Are Highly Toxic to Cultured Cells and Primary Neurons
journal, May 2006
- Novitskaya, Vera; Bocharova, Olga V.; Bronstein, Igor
- Journal of Biological Chemistry, Vol. 281, Issue 19
Detection and reduction of microaggregates in insulin preparations
journal, September 2010
- Heldt, Caryn L.; Sorci, Mirco; Posada, David
- Biotechnology and Bioengineering, Vol. 108, Issue 1
Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice
journal, December 2007
- Martins, Ivo Cristiano; Kuperstein, Inna; Wilkinson, Hannah
- The EMBO Journal, Vol. 27, Issue 1
Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils
journal, June 2009
- Chatani, E.; Lee, Y. -H.; Yagi, H.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 27
Early Events in Insulin Fibrillization Studied by Time-Lapse Atomic Force Microscopy
journal, January 2006
- Podestà, Alessandro; Tiana, Guido; Milani, Paolo
- Biophysical Journal, Vol. 90, Issue 2
In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis
journal, March 2003
- Stine, W. Blaine; Dahlgren, Karie N.; Krafft, Grant A.
- Journal of Biological Chemistry, Vol. 278, Issue 13
Characterization of the nanoscale properties of individual amyloid fibrils
journal, October 2006
- Smith, J. F.; Knowles, T. P. J.; Dobson, C. M.
- Proceedings of the National Academy of Sciences, Vol. 103, Issue 43
Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway
journal, February 2007
- Lee, S.; Fernandez, E. J.; Good, T. A.
- Protein Science, Vol. 16, Issue 4
What Drives Amyloid Molecules To Assemble into Oligomers and Fibrils?
journal, January 2011
- Schmit, Jeremy D.; Ghosh, Kingshuk; Dill, Ken
- Biophysical Journal, Vol. 100, Issue 2
Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient
journal, March 1988
- Dische, F. E.; Wernstedt, C.; Westermark, G. T.
- Diabetologia, Vol. 31, Issue 3
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
journal, June 2008
- Shankar, Ganesh M.; Li, Shaomin; Mehta, Tapan H.
- Nature Medicine, Vol. 14, Issue 8
Genetic Engineering Combined with Deep UV Resonance Raman Spectroscopy for Structural Characterization of Amyloid-like Fibrils
journal, May 2008
- Sikirzhytski, Vitali; Topilina, Natalya I.; Higashiya, Seiichiro
- Journal of the American Chemical Society, Vol. 130, Issue 18
Molecular recycling within amyloid fibrils
journal, July 2005
- Carulla, Natàlia; Caddy, Gemma L.; Hall, Damien R.
- Nature, Vol. 436, Issue 7050
Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases
journal, May 2008
- Whitmore, Lee; Wallace, B. A.
- Biopolymers, Vol. 89, Issue 5, p. 392-400
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
journal, November 2002
- LaFerla, Frank M.
- Nature Reviews Neuroscience, Vol. 3, Issue 11
Asymmetric amyloid fibril elongation: A new perspective on a symmetric world
journal, October 2010
- Heldt, Caryn L.; Zhang, Shuqi; Belfort, Georges
- Proteins: Structure, Function, and Bioinformatics, Vol. 79, Issue 1
Protein denaturation with guanidine hydrochloride or urea provides a different estimate of stability depending on the contributions of electrostatic interactions
journal, November 1994
- Monera, Oscar D.; Kay, Cyril M.; Hodges, Robert S.
- Protein Science, Vol. 3, Issue 11
Amyloid ion channels: A common structural link for protein-misfolding disease
journal, July 2005
- Quist, A.; Doudevski, I.; Lin, H.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 30
Structural Classification of Toxic Amyloid Oligomers
journal, August 2008
- Glabe, Charles G.
- Journal of Biological Chemistry, Vol. 283, Issue 44
Probing the Nucleus Model for Oligomer Formation during Insulin Amyloid Fibrillogenesis
journal, December 2010
- Pease, Leonard F.; Sorci, Mirco; Guha, Suvajyoti
- Biophysical Journal, Vol. 99, Issue 12
Time-dependent insulin oligomer reaction pathway prior to fibril formation: Cooling and seeding
journal, October 2009
- Sorci, Mirco; Grassucci, Robert A.; Hahn, Ingrid
- Proteins: Structure, Function, and Bioinformatics, Vol. 77, Issue 1
Effect of Environmental Factors on the Kinetics of Insulin Fibril Formation: Elucidation of the Molecular Mechanism †
journal, May 2001
- Nielsen, Liza; Khurana, Ritu; Coats, Alisa
- Biochemistry, Vol. 40, Issue 20
Amyloid fibers provide structural integrity to Bacillus subtilis biofilms
journal, January 2010
- Romero, D.; Aguilar, C.; Losick, R.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 5
Molecular basis for insulin fibril assembly
journal, October 2009
- Ivanova, Magdalena I.; Sievers, Stuart A.; Sawaya, Michael R.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 45
Effect of Trehalose on W7FW14F Apomyoglobin and Insulin Fibrillization: New Insight into Inhibition Activity
journal, January 2008
- Vilasi, Silvia; Iannuzzi, Clara; Portaccio, Marianna
- Biochemistry, Vol. 47, Issue 6
Analysis of protein circular dichroism spectra for secondary structure using a simple matrix multiplication
journal, May 1986
- Compton, Larry A.; Johnson, W. Curtis
- Analytical Biochemistry, Vol. 155, Issue 1
Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicity
journal, January 2010
- Friedrich, Ralf P.; Tepper, Katharina; Rönicke, Raik
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 5
A colorimetric assay for viral agents that produce cytopathic effects
journal, July 2006
- Heldt, Caryn L.; Hernandez, Raquel; Mudiganti, Usharani
- Journal of Virological Methods, Vol. 135, Issue 1
ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
journal, June 2010
- Bolognesi, Benedetta; Kumita, Janet R.; Barros, Teresa P.
- ACS Chemical Biology, Vol. 5, Issue 8
Stabilization of neurotoxic Alzheimer amyloid- oligomers by protein engineering
journal, August 2010
- Sandberg, A.; Luheshi, L. M.; Sollvander, S.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 35
A Protein Caught in a Kinetic Trap: Structures and Stabilities of Insulin Disulfide Isomers
journal, November 2002
- Hua, Qing-Xin; Jia, Wenhua; Frank, Bruce H.
- Biochemistry, Vol. 41, Issue 50
The Mechanism of Amyloid Spherulite Formation by Bovine Insulin
journal, March 2005
- Krebs, M. R. H.; Bromley, E. H. C.; Rogers, S. S.
- Biophysical Journal, Vol. 88, Issue 3
Primary Steps of pH-Dependent Insulin Aggregation Kinetics are Governed by Conformational Flexibility
journal, June 2009
- Haas, Jürgen; Vöhringer-Martinez, Esteban; Bögehold, Andreas
- ChemBioChem, Vol. 10, Issue 11
Method for measuring neurotoxicity of aggregating polypeptides with the MTT assay on differentiated neuroblastoma cells
journal, December 2003
- Datki, Zsolt; Juhász, Anna; Gálfi, Márta
- Brain Research Bulletin, Vol. 62, Issue 3
A causative link between the structure of aberrant protein oligomers and their toxicity
journal, January 2010
- Campioni, Silvia; Mannini, Benedetta; Zampagni, Mariagioia
- Nature Chemical Biology, Vol. 6, Issue 2
Dissolution of 2-Microglobulin Amyloid Fibrils by Dimethylsulfoxide
journal, July 2003
- Hirota-Nakaoka, N.
- Journal of Biochemistry, Vol. 134, Issue 1
Hen egg white lysozyme fibrillation: a deep-UV resonance Raman spectroscopic study
journal, August 2008
- Xu, Ming; Ermolenkov, Vladimir V.; Uversky, Vladimir N.
- Journal of Biophotonics, Vol. 1, Issue 3
Seeded growth of -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure
journal, April 2009
- Paravastu, A. K.; Qahwash, I.; Leapman, R. D.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 18