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Title: A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging

New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)]2O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)]2O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)]2O to melanoma tissues transplanted into the tails of mice using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)]2O was visualized by MRI. Thus, [Fe(salen)]2O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [5] ;  [6] ;  [5] ;  [7] ;  [8] ;  [9] ;  [5] ;  [5] ;  [10] ;  [6] ;  [2] ;  [11] ;  [12] ;  [13] ;  [5]
  1. IHI Corp., Yokohama (Japan)
  2. Japan Synchrotron Radiation Research Institute, Hyogo (Japan)
  3. Yamagata Univ. (Japan)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  5. Yokohama City Univ. (Japan)
  6. Yokohama National Univ. (Japan)
  7. Univ. of Tokyo (Japan)
  8. Kyoto Univ. (Japan)
  9. Konan Univ., Kobe (Japan)
  10. Aichi Medical Univ., Aichi(Japan)
  11. National Inst. of Radiological Sciences, Chiba (Japan)
  12. Tohoku Univ., Sendai (Japan)
  13. International Graduate School of Arts and Sciences, Yokohama (Japan)
Publication Date:
OSTI Identifier:
1185340
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 5; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES