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Title: Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus

Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, in combined with bioinformatic analyses, allowed us to propose a biosynthetic pathway for terreic acid. Lastly, defining the pathway and the genes involved will facilitate the engineering of this molecule with interesting antimicrobial and antitumor bioactivities.
Authors:
 [1] ;  [1] ;  [2] ;  [3]
  1. Univ. of Southern California, Los Angeles, CA (United States). Dept. of Pharmacology and Pharmaceutical Sciences
  2. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  3. Univ. of Southern California, Los Angeles, CA (United States). Dept. of Pharmacology and Pharmaceutical Sciences; Univ. of Southern California, Los Angeles, CA (United States). Dept. of Chemistry
Publication Date:
OSTI Identifier:
1167618
Report Number(s):
PNNL-SA--102991
Journal ID: ISSN 1523-7060; BM0101020
Grant/Contract Number:
AC05-76RL01830; PO1GM084077; 1136903
Type:
Accepted Manuscript
Journal Name:
Organic Letters
Additional Journal Information:
Journal Volume: 16; Journal Issue: 20; Journal ID: ISSN 1523-7060
Publisher:
American Chemical Society
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE Office of Energy Efficiency and Renewable Energy (EERE), Bioenergy Technologies Office (EE-3B)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES Aspergillus terreus; terreic acid; natural products; quinone epoxide