Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection
Abstract
Controlled integration of features that enhance the analytical performance of a sensor chip is a challenging task in the development of paper sensors. A critical issue in the fabrication of low-cost biosensor chips is the activation of the device surface in a reliable and controllable manner compatible with large-scale production. Here, we report stable, well-adherent, and repeatable site-selective deposition of bioreactive amine functionalities and biorepellant polyethylene glycol-like (PEG) functionalities on paper sensors by aerosol-assisted, atmospheric-pressure, plasma-enhanced chemical vapor deposition. This approach requires only 20 s of deposition time, compared to previous reports on cellulose functionalization, which takes hours. We present a detailed analysis of the near-edge X-ray absorption fine structure (NEXAFS) and its sensitivity to the local electronic structure of the carbon and nitrogen functionalities. σ*, π*, and Rydberg transitions in C and N K-edges. Lastly, application of the plasma-processed paper sensors in DNA detection is also demonstrated.
- Authors:
-
- NASA Ames Research Center, Moffett Field, California 94035, United States
- Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States
- Publication Date:
- Research Org.:
- SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Aeronautics and Space Administration (NASA); National Institutes of Health (NIH)
- OSTI Identifier:
- 1165085
- Alternate Identifier(s):
- OSTI ID: 1295338
- Grant/Contract Number:
- AC02-76SF00515; P41GM103393
- Resource Type:
- Published Article
- Journal Name:
- ACS Applied Materials and Interfaces
- Additional Journal Information:
- Journal Name: ACS Applied Materials and Interfaces Journal Volume: 6 Journal Issue: 24; Journal ID: ISSN 1944-8244
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; cellulose functionalization; DNA detection; NEXAFS; paper sensors; X-ray absorption
Citation Formats
Gandhiraman, Ram P., Nordlund, Dennis, Jayan, Vivek, Meyyappan, M., and Koehne, Jessica E. Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection. United States: N. p., 2014.
Web. doi:10.1021/am5069003.
Gandhiraman, Ram P., Nordlund, Dennis, Jayan, Vivek, Meyyappan, M., & Koehne, Jessica E. Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection. United States. https://doi.org/10.1021/am5069003
Gandhiraman, Ram P., Nordlund, Dennis, Jayan, Vivek, Meyyappan, M., and Koehne, Jessica E. Fri .
"Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection". United States. https://doi.org/10.1021/am5069003.
@article{osti_1165085,
title = {Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection},
author = {Gandhiraman, Ram P. and Nordlund, Dennis and Jayan, Vivek and Meyyappan, M. and Koehne, Jessica E.},
abstractNote = {Controlled integration of features that enhance the analytical performance of a sensor chip is a challenging task in the development of paper sensors. A critical issue in the fabrication of low-cost biosensor chips is the activation of the device surface in a reliable and controllable manner compatible with large-scale production. Here, we report stable, well-adherent, and repeatable site-selective deposition of bioreactive amine functionalities and biorepellant polyethylene glycol-like (PEG) functionalities on paper sensors by aerosol-assisted, atmospheric-pressure, plasma-enhanced chemical vapor deposition. This approach requires only 20 s of deposition time, compared to previous reports on cellulose functionalization, which takes hours. We present a detailed analysis of the near-edge X-ray absorption fine structure (NEXAFS) and its sensitivity to the local electronic structure of the carbon and nitrogen functionalities. σ*, π*, and Rydberg transitions in C and N K-edges. Lastly, application of the plasma-processed paper sensors in DNA detection is also demonstrated.},
doi = {10.1021/am5069003},
journal = {ACS Applied Materials and Interfaces},
number = 24,
volume = 6,
place = {United States},
year = {Fri Dec 05 00:00:00 EST 2014},
month = {Fri Dec 05 00:00:00 EST 2014}
}
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