National Library of Energy BETA

Sample records for y1 submitted a1

  1. Submitting PDSF Jobs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    This means that if you load a module on a login node and then submit a job with the "-V" ... Instead, you should load the modules in the script you are submitting to the batch system ...

  2. Submitting Jobs To Mendel+

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Jobs To Mendel+ Submitting Jobs To Mendel+ New compute nodes ("Mendel+") have been installed at NERSC's new CRT building, and they are available for JGI staff. This document...

  3. DATE SUBMITTED: GRADE LEVEL:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    two total hours per visit. For more students than that, please plan a visit on another date. To make a request, please complete the form below and submit it to...

  4. Submit CSES Proposals

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submit Proposals Submit CSES Proposals High quality, cutting-edge science in the areas of astrophysics, space physics, solid planetary geoscience, and climate science. Contact Director Reiner Friedel (505) 665-1936 Email Professional Staff Assistant Georgia D. Sanchez (505) 665-0855 Email FY16 Call for Proposals period is now closed. The Center for Space and Earth Science (CSES) at Los Alamos National Laboratory (LANL) annually solicits proposals in the disciplines of geoscience, climate,

  5. Submitting Batch Jobs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submitting Batch Jobs Submitting Batch Jobs Debug Jobs Short jobs requesting less than 30 minutes and requiring 512 nodes (2,048 cores) or fewer can run in the debug queue. From 5am-6pm Pacific Time, 256 nodes are reserved for debugging and interactive use. See also, running Interactive Jobs. Sample Batch Scripts The following batch script requests 8 cores on 2 nodes with a 10 minute wall clock limit in the debug queue. Torque directive lines tell the batch system how to run a job and begin with

  6. ABSTRACTS FOR PAPERS SUBMITTED

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FOR PAPERS SUBMITTED April 1, 2001 - March 31, 2002 Mid-rapidity and Λ Λ Production in Au+Au Collisions at NN S = 103 GeV STAR Collaboration Phys. Rev. Lett. (submitted) We report the first measurement of strange ( and anti-strange ) Λ ) Λ ( baryon production from NN S = 130 GeV Au + Au collisions at the Relativistic Heavy Ion Collider (RHIC). Rapidity density and transverse mass distributions at mid-rapidity are presented as a function of centrality. The yield of ( and ) Λ ) (Λ hyperons

  7. User Submitted Research Citations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    User Submitted Research Citations User Submitted Research Citations Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category Picture1 Miro Conjugation-Driven "Reverse Mars-van Krevelen"-Type Radical Mechanism for Low-Temperature C-O Bond Activation June 9, 2016 | Author(s): Alexander V. Mironenko. Dionisios G. Vlachos | Source: Mironenko, Alexander V., and Dionisios G. Vlachos. "Conjugation-driven "Reverse Mars-van Krevelen"-type Radical Mechanism

  8. FINAL Submitted to NREL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Submitted to NREL 10-21-11 City of Naperville Case Study 1 An example of an automated switch used in Naperville's distribution automation systems. At the Forefront of the Smart Grid: Empowering Consumers in Naperville, Illinois Naperville, Illinois, is a suburban community located outside of Chicago. Typical in many ways, Naperville is the fifth largest city in Illnois and an active, engaged citizenry that is environmentally conscious and technically savvy. In fact, the National Renewable Energy

  9. Submitting Comments via Email

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Submitting Comments via Email Any contact information provided in your e-mail submission will not be publicly viewable except for your first and last names, organization name (if any), and submitter representative name (if any). Your contact information will be publicly viewable if you include it in the comment itself or in any documents attached to your comment. Any information that you do not want to be publicly viewable should not be included in your comment, nor in any document attached to

  10. ARM - Submitting Proposals : Guideline Overview

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    govField CampaignsSubmitting Proposals : Guideline Overview Guidelines Overview Annual Facility Call Proposal Deadline Guidance Small Field Campaigns Review Criteria Expectations for Principal Investigators Forms Propose a Campaign Instrument Support Request (ISR) Form (Word, 89KB) Unmanned Aerial System (UAS) Mission Request Form (Word, 72KB) Documentation Submitting Field Campaign Data and Metadata Field Campaign Guidelines (PDF, 574KB) Unmanned Aerial System Operation Safety at ARM Sites

  11. Submitting Work | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submitting Work Customers may directly contact the supervisor of the required service area to discuss the technical details of proposed projects. Iowa State University requestors need to bring an Intramural Purchase Order (IPO) with them from their departmental office to request services. After the technical details of the project are known, a cost estimate is prepared. Ames Laboratory operations work less than $1,000 is submitted directly to the shop using the Engineering Services Shop -

  12. NNSA Personnel Appointments Announced Administrator Gordon Submits...

    National Nuclear Security Administration (NNSA)

    Personnel Appointments Announced Administrator Gordon Submits Organizational Plan to Congress | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People...

  13. Historical - Submitting Environmental Impact Statements (EPA, 2011) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Historical - Submitting Environmental Impact Statements (EPA, 2011) Historical - Submitting Environmental Impact Statements (EPA, 2011) Guidance from the Environmental Protection Agency's Office of Federal Activities on the filing of EISs. Submitting Environmental Impact Statements (41.64 KB) More Documents & Publications Partially Superceded - Frequently Asked Questions on Filing EISs with EPA's Office of Federal Activities (EPA, 1994) EIS-0470: EPA Amended Notice

  14. ARM - Submitting Field Campaign Data and Metadata

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Field Campaign Data and Metadata Guidelines Overview Annual Facility Call Proposal Deadline Guidance Small Field Campaigns Review Criteria Expectations for Principal Investigators Forms Propose a Campaign Instrument Support Request (ISR) Form (Word, 89KB) Unmanned Aerial System (UAS) Mission Request Form (Word, 72KB) Documentation Submitting Field Campaign Data and Metadata Field Campaign Guidelines (PDF, 574KB) Unmanned Aerial System Operation Safety at ARM Sites (PDF, 639KB) Submitting Field

  15. Submitting Organization Hongyou Fan Sandia National Laboratories

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

     2007 R&D 100 Award Entry Form  Submitting Organization Hongyou Fan Sandia National Laboratories Advanced Materials Laboratory 1001 University Boulevard SE Albuquerque, NM 87106, USA 505-272-7128 (phone) 505-272-7336 (fax) hfan@sandia.gov AFFIRMATION: I affirm that all information submitted as a part of, or supplemental to, this entry is a fair and accurate represen- tation of this product. Submitter's signature_______________________________ Earl Stromberg Lockheed Martin

  16. Fermilab Office of General Counsel - Ethics Program - Submit...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ask the Ethicist Questions & Answers Submit a Question Annual Reminders Reporting Fraud Holiday Parties Fermilab employees can complete the form below to submit a question to...

  17. Radiation Exposure Monitoring Systems Program Policy for Submitting...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Program Policy for Submitting of PII information Radiation Exposure Monitoring Systems ... Guide. PDF icon Radiation Exposure Monitoring Systems Program Policy for Submitting ...

  18. How to Submit a 2016 ERCAP (Allocations) Request

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submit a 2016 ERCAP Request How to Submit a 2016 ERCAP (Allocations) Request September 1, 2015 Last edited: 2016-04-29 11:34:25

  19. Video Tutorial for Submitting a 2014 ERCAP Request available

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Video Tutorial for Submitting a 2014 ERCAP Request available Video Tutorial for Submitting a 2014 ERCAP Request available September 17, 2013 Rushing to meet the September 22nd...

  20. Microsoft Word - 45201 Submitted Dec 2003.doc

    Office of Legacy Management (LM)

    30 Long-term Monitoring Plan for the Central Nevada Test Area Prepared by Ahmed E. Hassan submitted to Nevada Site Office National Nuclear Security Administration U.S. Department of Energy Las Vegas, Nevada SEPTEMBER 2003 Publication No. 45201 Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any

  1. NOVA Portal: Submit VASP Jobs to Carver via the Web

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NOVA Portal: Submit VASP Jobs to Carver via the Web NOVA Portal: Submit VASP Jobs to Carver via the Web May 11, 2012 by Francesca Verdier NOVA is an experimental web application ...

  2. Radiation Exposure Monitoring Systems Program Policy for Submitting of PII

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    information | Department of Energy Exposure Monitoring Systems Program Policy for Submitting of PII information Radiation Exposure Monitoring Systems Program Policy for Submitting of PII information ‎December 17, ‎2015 The REMS Program Policy for submitting of PII information in accordance with the Office of Environment, Health, Safety and Security (EHSS) under DOE Order 231.1B and the REMS Reporting Guide. Radiation Exposure Monitoring Systems Program Policy for Submitting of PII

  3. Video Tutorial for Submitting a 2014 ERCAP Request available

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Video Tutorial for Submitting a 2014 ERCAP Request available Video Tutorial for Submitting a 2014 ERCAP Request available September 17, 2013 Rushing to meet the September 22nd deadline for submitting your 2014 ERCAP renewal request? Would you spend sixteen and a half minutes to possibly save hours of frustration? Then check out the new video tutorial on How to Submit a 2014 ERCAP Request and get the information you need to speed through your ERCAP submission and save yourself time and

  4. Strategic Plan Submitted to the Secretary | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Strategic Plan Submitted to the Secretary Strategic Plan Submitted to the Secretary Strategic Plan Submitted to the Secretary (813.64 KB) More Documents & Publications Secretary Directs FPO to Prepare Strategic Plan Welcome to the Cultural Resources Newsletter Microsoft Word - April06.doc

  5. SUBMITTED TO IDMS 03/29/2016.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SUBMITTED TO IDMS 03/29/2016. PAPERWORK REDUCTION ACT STATEMENT: Public nreoft burden fmr lIhe clW00" 0 Ifft R1rma1 I h aehnd to average-.0 hours per tesicnae hiduding "h Ibne for reiewing ini~rciormn, seawihNg exisig dale source, gallwbi mcd montaknki ft das neeaded, and aim"&*r and revavfti the =Aec~a n hd maln seid conmeen = di burden extirns or anV cow a-"dt of V*t coaeciin of kIformdr~on. hkdud~e suftaslona lot reducing V*~ burden, to U.S. GsswW Serd*ft Adminlsrafio,

  6. NOVA Portal: Submit VASP Jobs to Carver via the Web

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NOVA Portal: Submit VASP Jobs to Carver via the Web NOVA Portal: Submit VASP Jobs to Carver via the Web May 11, 2012 by Francesca Verdier NOVA is an experimental web application that enables users to submit VASP jobs to NERSC resources. You must be a licensed VASP user in order to submit jobs through NOVA. This initial version of NOVA runs only on Carver. Most input files can be prepared either by manipulating graphical controls, or by copying and pasting text and editing in the browser. NOVA

  7. Radiation Exposure Monitoring Systems Program Policy for Submitting...

    Broader source: Energy.gov (indexed) [DOE]

    Reporting Guide. Radiation Exposure Monitoring Systems Program Policy for Submitting of PII information (11.69 KB) More Documents & Publications Radiation Exposure Monitoring ...

  8. New Procedures for Submitting Clause or Template Changes

    Broader source: Energy.gov [DOE]

    Attached are the new procedures for submitting requests for clause or template changes to the official versions of the clauses and templates contained in STRIPES

  9. REMS Program Policy for submitting of Personally Identifiable...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Office of Environment, Health, Safety and Security (AU) systems has identified that the radiation exposure records submitted to the Radiation Exposure Monitoring System (REMS)...

  10. EPA Tier2 Submit Software Webpage | Open Energy Information

    Open Energy Info (EERE)

    Not Provided DOI Not Provided Check for DOI availability: http:crossref.org Online Internet link for EPA Tier2 Submit Software Webpage Citation United States Environmental...

  11. Spin and orbital ordering in Y1-xLaxVO₃

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yan, J.-Q.; Zhou, J.-S.; Cheng, J. G.; Goodenough, J. B.; Ren, Y.; Llobet, A.; McQueeney, R. J.

    2011-12-02

    The spin and orbital ordering in Y1-xLaxVO₃ (0.30 ≤ x ≤ 1.0) has been studied to map out the phase diagram over the whole doping range 0 ≤ x ≤ 1. The phase diagram is compared with that for RVO₃ (R = rare earth or Y) perovskites without A-site variance. For x > 0.20, no long-range orbital ordering was observed above the magnetic ordering temperature TN; the magnetic order is accompanied by a lattice anomaly at a Tt ≤ TN as in LaVO₃. The magnetic ordering below Tt ≤ TN is G type in the compositional range 0.20 ≤ xmore » ≤ 0.40 and C type in the range 0.738 ≤ x ≤ 1.0. Magnetization and neutron powder diffraction measurements point to the coexistence below TN of the two magnetic phases in the compositional range 0.4 < x < 0.738. Samples in the compositional range 0.20 < x ≤ 1.0 are characterized by an additional suppression of a glasslike thermal conductivity in the temperature interval TN < T < T* and a change in the slope of 1/χ(T). We argue that T* represents a temperature below which spin and orbital fluctuations couple together via λL∙S.« less

  12. DOE Warns Manufacturers Who Submitted Incomplete Certification Reports

    Broader source: Energy.gov [DOE]

    Washington, DC - The Department of Energy’s Office of General Counsel has sent warning letters to 9 manufacturers or trade associations that submitted incomplete energy-efficiency test data to...

  13. Submit Your Home Energy Efficiency Questions Now for Earth Day...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Saver for tips and advice on ways to save energy and money. Addthis Related Articles This Earth Day, Get Your Energy-Saving Questions Answered Submit Your Home Energy ...

  14. Instructions for Submitting Document to OpenNet | Department...

    Energy Savers [EERE]

    Requesting an account to submit documents to OpenNet If you plan to load documents to OpenNet, you must have an OpenNet Logon Name and Password. If you don't already have one, go ...

  15. DOE Marks Milestone in Submitting Yucca Mountain License Application |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Milestone in Submitting Yucca Mountain License Application DOE Marks Milestone in Submitting Yucca Mountain License Application June 3, 2008 - 12:51pm Addthis WASHINGTON, DC - The U.S. Department of Energy (DOE) today announced submittal of a license application (LA) to the U.S. Nuclear Regulatory Commission (NRC) seeking authorization to construct America's first repository for spent nuclear fuel and high-level radioactive waste at Yucca Mountain, Nevada. The 8,600 page

  16. Comment submitted by Traulsen regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by Traulsen regarding the Energy Star Verification Testing Program

  17. Comment submitted by Whirlpool Corporation regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by Whirlpool Corporation regarding the Energy Star Verification Testing Program

  18. Comment submitted by Consumers Union regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by Consumers Union regarding the Energy Star Verification Testing Program

  19. Comment submitted by Earthjustice regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by Earthjustice regarding the Energy Star Verification Testing Program

  20. Attachment A1

    Office of Environmental Management (EM)

    A1 CONTAINER STORAGE Waste Isolation Pilot Plant Hazardous Waste Permit October 2013 (This page intentionally blank) Waste Isolation Pilot Plant Hazardous Waste Permit October 2013 ...

  1. Appendix A-1

    Broader source: Energy.gov (indexed) [DOE]

    A-1 Table -1 This scale is created to provide a guide for the physician determination of ability to work for HRP certified persons with certain conditions and while taking certain ...

  2. How to Apply – Step 2: Complete and Submit Your Application

    Broader source: Energy.gov [DOE]

    To submit an application for Office of Energy Efficiency and Renewable Energy Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) grant you will need to provide a Letter of Intent (LOI) prior to submitting your full application.

  3. How to Submit an ERCAP (allocations) Request (Allocation Year 2013 version)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submitting an ERCAP Request (2013) How to Submit an ERCAP (allocations) Request (Allocation Year 2013 version) September 6, 2012 Last edited: 2016-04-28 15:17:23

  4. How to Submit a Request for a PARS II Account | Department of...

    Energy Savers [EERE]

    How to Submit a Request for a PARS II Account How to Submit a Request for a PARS II Account The account access process for PARS II relies on the Department of Energy's iManage...

  5. Submit Your Ideas for the NY Energy Data Jam | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Submit Your Ideas for the NY Energy Data Jam Submit Your Ideas for the NY Energy Data Jam June 19, 2013 - 11:03am Q&A What idea would you present at the Data Jam? Join the...

  6. Aerosys Agrees to Pay Civil Penalty and Submit Test Data in Settlement...

    Office of Environmental Management (EM)

    Aerosys Agrees to Pay Civil Penalty and Submit Test Data in Settlement with DOE Aerosys Agrees to Pay Civil Penalty and Submit Test Data in Settlement with DOE July 6, 2010 - ...

  7. Comment submitted by Energizer Battery Manufacturing, Inc. regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by Energizer Battery Manufacturing, Inc. regarding the Energy Star Verification Testing Program

  8. Comment submitted by CertainTeed Corporation regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by CertainTeed Corporation regarding the Energy Star Verification Testing Program

  9. Comment submitted by Ingersoll Rand Residential Solutions regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by Ingersoll Rand Residential Solutions regarding the Energy Star Verification Testing Program

  10. Comment submitted by United Lighting, Inc. regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by United Lighting, Inc. regarding the Energy Star Verification Testing Program

  11. Comment submitted by BSH Home Appliances Corporation regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by BSH Home Appliances Corporation regarding the Energy Star Verification Testing Program

  12. Comment submitted by InterMetro Industries Corp. regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by InterMetro Industries Corp. regarding the Energy Star Verification Testing Program

  13. Comment submitted by Hobart/ITW Food Equipment Group regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by Hobart/ITW Food Equipment Group regarding the Energy Star Verification Testing Program

  14. Comment submitted by Hoshizaki America, Inc. regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by Hoshizaki America, Inc. regarding the Energy Star Verification Testing Program

  15. Comment submitted by the Bradford White Corporation (BWC) regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by the Bradford White Corporation (BWC) regarding the Energy Star Verification Testing Program

  16. Comment submitted by the Natural Resources Defense Council (NRDC) regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by the Natural Resources Defense Council (NRDC) regarding the Energy Star Verification Testing Program

  17. Comment submitted by A. O. Smith Corporation regarding the Energy Star Verification Testing Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    This document is a comment submitted by A. O. Smith Corporation regarding the Energy Star Verification Testing Program

  18. Comment submitted by the Alliance for Water Efficiency (AWE) regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by the Alliance for Water Efficiency (AWE) regarding the Energy Star Verification Testing Program

  19. For Individual Lab Researchers - Submit metadata to your lab's internal

    Office of Scientific and Technical Information (OSTI)

    STI system or your lab's STI Manager | OSTI, US Dept of Energy Office of Scientific and Technical Information Individual Lab Researchers DataCite | Contact DOE Data ID Service Call or email your organization's Scientific and Technical Information (STI) Manager. Explain your need to submit a dataset to support a publication and/or to receive a DOI. Ask if your lab has been assigned a unique DOI prefix. The answer should be "yes." If it is not, the STI Manager will need to contact

  20. Submitting a Proposal to DOE | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Submitting a Proposal to DOE Visiting Faculty Program (VFP) VFP Home Eligibility Benefits Participant Obligations How to Apply Selecting a Host DOE Laboratory Developing a Research Proposal Recommender Information Student Participants Submitting a Proposal to DOE Application Selection Process and Notification Key Dates Frequently Asked Questions Contact WDTS Home How to Apply Submitting a Proposal to DOE Print Text Size: A A A FeedbackShare Page Through direct collaboration with research staff

  1. Submit Your Comment for the Quadrennial Energy Review by July 1 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Submit Your Comment for the Quadrennial Energy Review by July 1 Submit Your Comment for the Quadrennial Energy Review by July 1 June 17, 2016 - 9:21am Addthis A series of seven public stakeholder meetings was recently held throughout the United States to gather public comments. Submit your comment by July 1. A series of seven public stakeholder meetings was recently held throughout the United States to gather public comments. Submit your comment by July 1. Help

  2. Submit Your Comments for the Quadrennial Energy Review by July 1 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Submit Your Comments for the Quadrennial Energy Review by July 1 Submit Your Comments for the Quadrennial Energy Review by July 1 June 21, 2016 - 1:40pm Addthis A series of seven public stakeholder meetings was recently held throughout the United States to gather public comments. Submit your comment by July 1. A series of seven public stakeholder meetings was recently held throughout the United States to gather public comments. Submit your comment by July 1. Learn More

  3. Deadline for Submitting Comments to the Second Installment of the QER Is

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    July 1 | Department of Energy Deadline for Submitting Comments to the Second Installment of the QER Is July 1 Deadline for Submitting Comments to the Second Installment of the QER Is July 1 June 22, 2016 - 1:25pm Addthis If you haven't submitted comments yet to the second installment of the Quadrennial Energy Review, you only have a few days left to do so. The deadline for submitting comments is July 1, 2016 - less than two weeks away. The Quadrennial Energy Review (QER) process, which has

  4. How to Submit a Freedom of Information Act Request | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    to Submit a Freedom of Information Act Request How to Submit a Freedom of Information Act Request How to Submit a Freedom of Information Act Request, from the U.S. Department of Energy's Golden Field Office. How to Submit a FOIA (67.71 KB) More Documents & Publications FIA-12-0063 - In the Matter of Native Hawaiian Legal Corporation. FIA-13-0013 - In the Matter of Taras Lyssenko FIA-12-0056 - In the Matter of Torres Consulting & Law Group, LLC

  5. Preparing to Submit a License Application for Yucca Mountain

    SciTech Connect (OSTI)

    W.J. Arthur; M.D. Voegele

    2005-03-14

    In 1982, the U.S. Congress passed the Nuclear Waste Policy Act, a Federal law that established U.S. policy for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Congress amended the Act in 1987, directing the Department of Energy to study only Yucca Mountain, Nevada as the site for a permanent geologic repository. As the law mandated, the Department evaluated Yucca Mountain to determine its suitability as the site for a permanent geologic repository. Decades of scientific studies demonstrated that Yucca Mountain would protect workers, the public, and the environment during the time that a repository would be operating and for tens of thousands of years after closure of the repository. A repository at this remote site would also: preserve the quality of the environment; allow the environmental cleanup of Cold War weapons facilities; provide the nation with additional protection from acts of terrorism; and support a sound energy policy. Throughout the scientific evaluation of Yucca Mountain, there has been no evidence to disqualify Yucca Mountain as a suitable site for the permanent disposal of spent nuclear fuel and high-level radioactive waste. Upon completion of site characterization, the Secretary of Energy considered the results and concluded that a repository at Yucca Mountain would perform in a manner that protects public health and safety. The Secretary recommended the site to the President in February 2002; the President agreed and recommended to Congress that the site be approved. The Governor of Nevada submitted a notice of disapproval, and both houses of Congress acted to override the disapproval. In July 2002, the President's approval allowed the Department to begin the process of submittal of a license application for Yucca Mountain as the site for the nation's first repository for spent nuclear fuel and high-level radioactive waste. Yucca Mountain is located on federal land in Nye County in southern Nevada, an arid region

  6. Idaho Request for Extension of Time to Submit Proof of Beneficial...

    Open Energy Info (EERE)

    Request for Extension of Time to Submit Proof of Beneficial Use (DWR Form 204) Jump to: navigation, search OpenEI Reference LibraryAdd to library Form: Idaho Request for Extension...

  7. Top U.S. Nuclear Official Commends Industry for Submitting 3rd...

    Office of Environmental Management (EM)

    Commission (NRC) for construction of a new nuclear power plant in the United States. ... "As the third complete license application for a new nuclear power plant submitted in less ...

  8. DOE Submits Its Defense-Related Uranium Mines Report to Congress

    Broader source: Energy.gov [DOE]

    Dr. Ernest Moniz, the U.S. Secretary of Energy, submitted the U.S. Department of Energy (DOE) Defense-Related Uranium Mines Report to Congress on September 2, 2014. Section 3151 of the National...

  9. Top U.S. Nuclear Official Commends Industry for Submitting 3rd Combined

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Construction & Operating License Application to the NRC | Department of Energy Nuclear Official Commends Industry for Submitting 3rd Combined Construction & Operating License Application to the NRC Top U.S. Nuclear Official Commends Industry for Submitting 3rd Combined Construction & Operating License Application to the NRC November 28, 2007 - 4:45pm Addthis RICHMOND, VA - The U.S. Department of Energy (DOE) Assistant Secretary for Nuclear Energy Dennis Spurgeon today commended

  10. How to Submit a FOIA Request | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    About » Field Operations » ISC Home » Freedom of Information Act (FOIA) » How to Submit a FOIA Request Integrated Support Center (ISC) ISC Home About Services Freedom of Information Act (FOIA) Privacy Act Advisory Exemptions How to Submit a FOIA Request FOIA Request Form Fee Waiver and Reduction Criteria Electronic Reading Room ISC Conventional Reading Rooms Reference Links Privacy Act NEPA Documents Contact Information Integrated Support Center Roxanne Purucker U.S. Department of Energy

  11. Instructions for Submitting Small Business Subcontracting Reports through the Electronic Subcontracting Reporting System (eSRS)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submitting Small Business Subcontracting Reports through the Electronic Subcontracting Reporting System (eSRS) All subcontractors who have Small Business Subcontracting Plans with the National Renewable Energy Laboratory (NREL) must submit their Individual Subcontract Reports (ISR) and Summary Subcontract Reports (SSR) through the Electronic Subcontracting Reporting System (eSRS). The eSRS is an electronic, web-based system for subcontract reporting that has replaced the SF 294 and SF 295 paper

  12. Predicting the future could win a $1,000 California or Illinois scholarship

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Predicting The Future Could Win California Or Illinois Scholarship Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue: September 1, 2016 all issues All Issues » submit Predicting the future could win a $1,000 California or Illinois scholarship To qualify, students need to post the answer to this question on their blog or website: "Where do you see the Internet in 10 years?" September 1, 2012 dummy image Read our archives

  13. Comment submitted by the North American Association of Food Equipment Manufacturers (NAFEM) regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by the North American Association of Food Equipment Manufacturers (NAFEM) regarding the Energy Star Verification Testing Program

  14. Comment submitted by the Association of Home Appliance Manufacturers (AHAM) regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by the Association of Home Appliance Manufacturers (AHAM) regarding the Energy Star Verification Testing Program

  15. Comment submitted by the Air Conditioning, Heating and Refrigeration Institute (AHRI) regarding the Energy Star Verification Testing Program

    Broader source: Energy.gov [DOE]

    This document is a comment submitted by the Air Conditioning, Heating and Refrigeration Institute (AHRI) regarding the Energy Star Verification Testing Program

  16. Submitting Jobs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    memory needed by your application. Use of a program like memtime during your benchmarking ahead of production may be informative. Specify a time limit for your job qsub -l...

  17. Submitted to:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    this is accomplished primarily by controlling the condenser fans to cool the compressed refrigerant below the factory-set standard operating pressure. Operation at lower head...

  18. Improved Thermoelectric Performance of p-type Skutterudite YbxFe4-yPtySb12 (0.8 x 1, y = 1 and 0.5)

    SciTech Connect (OSTI)

    Cho, Jung Y; Ye, Zuxin; Tessema, Misle; Salvador, James R.; Waldo, Richard; Yang, Jiong; Zhang, Weiqing; Yang, Jihui; Cai, Wei; Wang, Hsin

    2013-01-01

    Thermoelectric performance of p-type skutterudites currently lags that of the corresponding n-type materials and improvement of this important class of materials have become the focus of considerable research effort world-wide. Recent calculations find promising band structural features in p-type skutterudite materials of the type AeFe3NiSb12 ( Ae = Ca, Sr, or Ba) which could potentially lead to excellent thermoelectric properties. Recent work on the Yb- filled analog of the these formulations (YbFe3NiSb12) however finds that the onset of intrinsic conduction at lower than expected temperatures deteriorates the performance above 500 K leading to poor performance in the temperature range of interest for automotive waste heat recovery applications. We therefore seek a way to increase the band gap in order to find a way to minimize the deleterious effects of intrinsic conduction. Here we present ab initio band structure calculations and the synthesis and thermoelectric properties of YbxFe4-yPtySb12 (0.8 x 1, y = 1 and 0.5). Ab initio calculations find that the band gap increases for YbFe3PtSb12 as compared to the Ni-containing analog, though no such increase in the band gap energy was found for as compared to YbFe3.5Ni0.5Sb12. The y = 1 samples shows a characteristic transition to intrinsic conduction with a decrease in the Seebeck coefficient at temperatures above 700 K. The increased carrier concentration in y = 0.5 virtually eliminates any evidence of intrinsic conduction and the Seebeck coefficients for these samples increase monotonically up to 750 K, resulting in power factors approaching 27 W/cm K2 at 750 K. These power factors combined with low thermal conductivity result in a ZT = 0.9 at 750 K for Yb0.95Fe3.5Pt0.5Sb12.

  19. Microstructure and properties of rapidly solidified beryllium-transition metal alloys. [With small amounts of Ti, Zr and Y (1-3 wt %)

    SciTech Connect (OSTI)

    Jacobson, L.A.; Richardson, S.

    1988-01-01

    Alloys of beryllium with small amounts of Ti, Zr and Y (1-3 wt %) were rapidly solidified using an arc hammer splat technique. Each of these elements forms a dilute eutectic with beryllium, and has very low solid solubility in the alpha phase. In the case of Ti, the Be-rich compound is TiBe/sub 12/, and for Zr and Y, the compound is MBe. The objective of the work was to achieve a fine, uniform dispersion of particles of the intermetallic compound. Since these compounds have very high melting points, it was expected that rapidly solidified microstructures would be relatively stable at elevated temperatures. This microstructural stability should result in improved high temperature properties for the alloys. Microstructures have been characterized using optical, scanning and transmission electron microscopy. Microhardness measurements have been made in order to determine the effects of rapid solidification and to evaluate the effects of high temperature exposure on microstructural stability and property retention. The results will be presented in light of the potential of these alloys for intermediate temperature application. 12 refs., 8 figs.

  20. DOE and FERC Jointly Submit Implementation Proposal for The National Action Plan on Demand Response to Congress

    Office of Energy Efficiency and Renewable Energy (EERE)

    The U.S. Department of Energy and the Federal Energy Regulatory Commission (FERC) jointly submitted to Congress a required “Implementation Proposal for The National Action Plan on Demand Response.”

  1. Appendix A-1 Contract Performance Reports ARRA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A-1 Contract Performance Reports ARRA December 2011 CHPRC-2011-12, Rev. 0 Contract DE-AC06-08RL14788 Deliverable C.3.1.3.1 - 1 Format 1 - Work Breakdown Structure Format 3 -...

  2. Microsoft Word - 7A1.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 Figure 1 Crystal structure of the 7A1 Fab' cocaine complex with the secondary structure of the antibody light (L) and heavy (H) chains colored in cyan. Substrate cocaine is also shown in spheres with yellow carbons, blue nitrogen, and red oxygens in the active site. High Resolution Snapshots for the Complete Reaction Cycle of a Cocaine Catalytic Antibody Xueyong Zhu 1 , Tobin J. Dickerson 2,3 , Claude J. Rogers 2,3 , Gunnar F. Kaufmann 2,3 , Jenny M. Mee 2,3 , Kathleen M. McKenzie 2,3 , Kim D.

  3. Insulating and metallic spin glass in KxFe2-?-yNiySe2 (0.06 ? y ? 1.44 ) single crystals

    SciTech Connect (OSTI)

    Ryu, Hyejin; Abeykoon, Milinda; Wang, Kefeng; Lei, Hechang; Lazarevic, N.; Warren, J. B.; Bozin, E. S.; Popovic, Z. V.; Petrovic, C.

    2015-05-04

    We report electron doping effects by Ni in KxFe2-?-yNiySe? (0.06 ? y ? 1.44) single crystal alloys. A rich ground state phase diagram is observed. Thus, a small amount of Ni (~ 4%) suppressed superconductivity below 1.8 K, inducing insulating spin glass magnetic ground state for higher Ni content. With further Ni substitution, metallic resistivity is restored. For high Ni concentration in the lattice the unit cell symmetry is high symmetry I4/mmm with no phase separation whereas both I4/m + I4/mmm space groups were detected in the phase separated crystals when concentration of Ni < Fe. The absence of superconductivity coincides with the absence of crystalline Fe vacancy order.

  4. Decommissioning Project of Bohunice A1 NPP

    SciTech Connect (OSTI)

    Stubna, M.; Pekar, A.; Moravek, J.; Spirko, M.

    2002-02-26

    The first (pilot) nuclear power plant A1 in the Slovak Republic, situated on Jaslovske Bohunice site (60 km from Bratislava) with the capacity of 143 MWel, was commissioned in 1972 and was running with interruptions till 1977. A KS 150 reactor (HWGCR) with natural uranium as fuel, D2O as moderator and gaseous CO2 as coolant was installed in the A1 plant. Outlet steam from primary reactor coolant system with the temperature of 410 C was led to 6 modules of steam generators and from there to turbine generators. Refueling was carried out on-line at plant full power. The first serious incident associated with refueling occurred in 1976 when a locking mechanism at a fuel assembly failed. The core was not damaged during that incident and following a reconstruction of the damaged technology channel, the plant continued in operation. However, serious problems were occurring with the integrity of steam generators (CO2 gas on primary side, water and steam on secondary side) when the plant had to be shut down frequently due to failures and subsequent repairs. The second serious accident occurred in 1977 when a fuel assembly was overheated with a subsequent release of D2O into gas cooling circuit due to a human failure in the course of replacement of a fuel assembly. Subsequent rapid increase in humidity of the primary system resulted in damages of fuel elements in the core and the primary system was contaminated by fission products. In-reactor structures had been damaged, too. Activity had penetrated also into certain parts of the secondary system via leaking steam generators. Radiation situation in the course of both events on the plant site and around it had been below the level of limits specified. Based on a technical and economical justification of the demanding character of equipment repairs for the restoration of plant operation, and also due to a decision made not to continue with further construction of gas cooled reactors in Czechoslovakia, a decision was made in

  5. EIS-0396: Notice of Extension of Time to Submit Scoping Comments |

    Office of Environmental Management (EM)

    Statement | Department of EnergyA> 1: EPA Notice of Availability of the Draft Environmental Impact Statement EIS-0391: EPA Notice of Availability of the Draft Environmental Impact Statement Tank Closure and Waste Management for the Hanford Site, Richland, WA EIS-0391-DEA-NOA-2009.pdf (134.82 KB) More Documents & Publications EIS-0387: EPA Notice of Availability of the Draft Environmental Impact Statement EIS-0527: EPA Notice of Availability of a Draft Programmatic Environmental Impact

  6. A 1-D dusty plasma photonic crystal

    SciTech Connect (OSTI)

    Mitu, M. L.; Ticoş, C. M.; Toader, D.; Banu, N.; Scurtu, A.; Department of Physics, University of Bucharest, 077125 Bucharest

    2013-09-21

    It is demonstrated numerically that a 1-D plasma crystal made of micron size cylindrical dust particles can, in principle, work as a photonic crystal for terahertz waves. The dust rods are parallel to each other and arranged in a linear string forming a periodic structure of dielectric-plasma regions. The dispersion equation is found by solving the waves equation with the boundary conditions at the dust-plasma interface and taking into account the dielectric permittivity of the dust material and plasma. The wavelength of the electromagnetic waves is in the range of a few hundred microns, close to the interparticle separation distance. The band gaps of the 1-D plasma crystal are numerically found for different types of dust materials, separation distances between the dust rods and rod diameters. The distance between levitated dust rods forming a string in rf plasma is shown experimentally to vary over a relatively wide range, from 650 μm to about 1350 μm, depending on the rf power fed into the discharge.

  7. {sup 151}Eu-Moessbauer spectroscopic and X-ray diffraction study on Eu {sub y}M{sub 1-y}O{sub 2-x} (0 {<=} y {<=} 1.0) (M = Th, U)

    SciTech Connect (OSTI)

    Masaki, Nobuyuki M. . E-mail: masaki@analchem.tokai.jaeri.go.jp; Otobe, Haruyoshi; Nakamura, Akio; Harada, Daijitsu; Hinatsu, Yukio

    2005-04-20

    {sup 151}Eu-Moessbauer spectroscopic and powder X-ray diffraction (XRD) study has been performed for the Eu {sub y}M{sub 1-y}O{sub 2-x} (M = Th and U) systems over the entire composition range of 0 {<=} y {<=} 1.0. The XRD results of the Eu-Th system showed that a very wide defect-fluorite (DF) type phase in which oxygen vacancies (V {sub O}) are disordered (x = y/2) is formed for 0 {<=} y < 0.5 and that two-phase regions sandwitching a narrow C-type (C) single phase around y {approx} 0.8 appear for 0.5 < y < 0.8 (DF + C) and 0.82 < y < 1.0 (C + B-type (monoclinic) Eu{sub 2}O{sub 3}). The Moessbauer results show that the isomer shifts (ISs) of Eu{sup 3+} in this system smoothly increase with Eu composition, y. The decrease of average coordination number (CN) of O{sup 2-} around Eu{sup 3+} with increasing y (CN = 8 - 2y) (x = y/2) results in the decrease of the average Eu-O bond length, which is due to the decrease of repulsion force between O{sup 2-} anions. This result confirms that the IS of Eu{sup 3+} correlates well with the average Eu-O bond length in oxide systems. For the Eu-U system, the lattice parameter, a {sub 0}, of the system decreases almost linearly with y, in accordance with the calculated a {sub 0} versus y curve for the oxygen-stoichiometric (i.e. x = 0) fluorite-type dioxide (CN = 8). The ISs of Eu{sup 3+} in this composition range remain almost constant around 0.5 mm/s, which is comparable to those of pyrochlore oxides (Eu{sub 2}Zr{sub 2}O{sub 7} and Eu{sub 2}Hf{sub 2}O{sub 7} (y = 0.5)) with O{sup 2-}-eight-fold coordinated Eu{sup 3+}(CN = 8)

  8. Microsoft Word - luo-y1.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1996, Randall 2003). Large-scale forcing data produced by the Atmospheric Radiation Measurement (ARM; Stokes and Schwartz 1994, Ackerman and Stokes 2003) program at the Southern...

  9. Recoverable degradation of blue InGaN-based light emitting diodes submitted to 3?MeV proton irradiation

    SciTech Connect (OSTI)

    De Santi, C.; Meneghini, M. Trivellin, N.; Gerardin, S.; Bagatin, M.; Paccagnella, A.; Meneghesso, G.; Zanoni, E.

    2014-11-24

    This paper reports on the degradation and recovery of two different series of commercially available InGaN-based blue light emitting diodes submitted to proton irradiation at 3?MeV and various fluences (10{sup 11}, 10{sup 13}, and 10{sup 14}?p{sup +}/cm{sup 2}). After irradiation, we detected (i) an increase in the series resistance, in the sub-turn-on current and in the ideality factor, (ii) a spatially uniform drop of the output optical power, proportional to fluence, and (iii) a reduction of the capacitance of the devices. These results suggest that irradiation induced the generation of non-radiative recombination centers near the active region. This hypothesis is further confirmed by the results of the recovery tests carried out at low temperature (150?C)

  10. U Isotopic Compositions and Concentrations of Rocky Flats Water Samples Collected Over the Period 4/1/15 to 6/16/15 and Submitted to LBNL

    Office of Legacy Management (LM)

    U Isotopic Compositions and Concentrations of Rocky Flats Water Samples Collected Over the Period 4/1/15 to 6/16/15 and Submitted to LBNL John N. Christensen Data Report date 12/30/15 Twenty-one water samples were submitted by SM Stoller to Lawrence Berkeley National Laboratory (LBNL) for uranium (U) isotopic analysis. The sample set includes four composite samples from the WALPOC location, one composite sample from GS10, one composite sample from the SW093 location, and one sample each from

  11. File:FormA1.pdf | Open Energy Information

    Open Energy Info (EERE)

    FormA1.pdf Jump to: navigation, search File File history File usage File:FormA1.pdf Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full resolution...

  12. Crystal structure, characterization and thermoelectric properties of the type-I clathrate Ba{sub 8-y}Sr{sub y}Al{sub 14}Si{sub 32} (0.6{<=}y{<=}1.3) prepared by aluminum flux

    SciTech Connect (OSTI)

    Roudebush, John H.; Toberer, Eric S.; Hope, Hakon; Jeffrey Snyder, G.; Kauzlarich, Susan M.

    2011-05-15

    The title compound was prepared as single crystals using an aluminum flux technique. Single crystal and powder X-ray diffraction indicate that this composition crystallizes in the clathrate type-I structure, space group Pm3-bar n. Electron microprobe characterization indicates the composition to be Ba{sub 8-y}Sr{sub y}Al{sub 14.2(2)}Si{sub 31.8(2)} (0.77<y<1.3). Single-crystal X-ray diffraction data (90 and 12 K) were refined with the Al content fixed at the microprobe value (12 K data: R{sub 1}=0.0233, wR{sub 2}=0.0441) on a crystal of compositions Ba. The Sr atom preferentially occupies the 2a position; mixed Al/Si occupancy was found on all framework sites. These refinements are consistent with a fully occupied framework and nearly fully occupied cation guest sites as found by microprobe analysis. Temperature dependent electrical resistivity and thermal conductivity have been measured from room temperature to 1200 K on a hot-pressed pellet. Electrical resistivity reveals metallic behavior. The negative Seebeck coefficient indicates transport processes dominated by electrons as carriers. Thermal conductivity is between 22 and 25 mW/cm K. The sample shows n-type conductivity with a maximum figure of merit, zT of 0.3 at 1200 K. A single parabolic band model predicts a five-fold increase in zT at 800 K if carrier concentration is lowered. -- Graphical abstract: The inorganic type-I clathrate phase with nominal composition Ba{sub 7}Sr{sub 1}Al{sub 14}Si{sub 32} has been prepared by Al flux. Single crystal diffraction at 90 and 12 K reveal that the framework is fully occupied with the cation sites nearly fully occupied. The lattice thermal conductivity is low thereby suggesting further optimization of the carrier concentration will lead to a high zT. Display Omitted Highlights: {yields} Ba{sub 7}Sr{sub 1}Al{sub 14}Si{sub 32} is a light element phase ideal for thermoelectric power generation. {yields} Ba{sub 7}Sr{sub 1}Al{sub 14}Si{sub 32} is a high melting point cubic

  13. Near-infrared spectroscopy of the Y0 WISEP J173835.52+273258.9 and the Y1 WISE J035000.32–565830.2: The importance of non-equilibrium chemistry

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Leggett, Sandy K.; Tremblin, Patrick; Saumon, Didier; Marley, Mark S.; Morley, Caroline V.; Amundsen, David S.; Baraffe, Isabelle; Chabrier, Gilles

    2016-06-03

    Here, we present new near-infrared spectra, obtained at Gemini Observatory, for two Y dwarfs: WISE J035000.32–565830.2 (W0350) and WISEP J173835.52+273258.9 (W1738). A FLAMINGOS-2 R = 540 spectrum was obtained for W0350, coveringmore » $$1.0\\lt \\lambda \\;\\mu {\\rm{m}}$$ $$\\lt \\;1.7$$, and a cross-dispersed Gemini near-infrared spectrograph R = 2800 spectrum was obtained for W1738, covering 0.993–1.087 μm, 1.191–1.305 μm, 1.589–1.631 μm, and 1.985–2.175 μm, in four orders. We also present revised YJH photometry for W1738, using new NIRI Y and J imaging, and a re-analysis of the previously published NIRI H-band images. We compare these data, together with previously published data for late-T and Y dwarfs, to cloud-free models of solar metallicity, calculated both in chemical equilibrium and with disequilibrium driven by vertical transport. We find that for the Y dwarfs, the non-equilibrium models reproduce the near-infrared data better than the equilibrium models. The remaining discrepancies suggest that fine-tuning the CH4/CO and NH3/N2 balance is needed. Improved trigonometric parallaxes would improve the analysis. Despite the uncertainties and discrepancies, the models reproduce the observed near-infrared spectra well. We find that for the Y0, W1738, $${T}_{{\\rm{eff}}}=425\\pm 25\\;{\\rm{K}}$$, and log $$g=4.0\\pm 0.25$$, and for the Y1, W0350, $${T}_{{\\rm{eff}}}=350\\pm 25\\;{\\rm{K}}$$, and log $$g=4.0\\pm 0.25$$. W1738 may be metal-rich. Based on evolutionary models, these temperatures and gravities correspond to a mass range for both Y dwarfs of 3–9 Jupiter masses, with W0350 being a cooler, slightly older, version of W1738; the age of W0350 is 0.3–3 Gyr, and the age of W1738 is 0.15–1 Gyr.« less

  14. FINAL Submitted to NREL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Geynisman, "The result is a more flexible and capable workforce with better training to maintain our modernized grid." Smart Metering Recovery Act funding has also positioned ...

  15. User Submitted Research Citations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Investigation into electron cloud effects in the International Linear Collider positron damping ring March 17, 2014 | Author(s): J. A. Crittenden, J. Conway, G. F. Dugan, M. A. Palmer, D. L. Rubin, J. Shanks, K. G. Sonnad, L. Boon, K. Harkay, T. Ishibashi, M. A. Furman, S. Guiducci, M. T. F. Pivi, and L. Wang | Source: Phys. Rev. ST Accel. Beams | URL: http://journals.aps.org/prstab/abstract/10.1103/PhysRevSTAB.17.031002 Dalt Trans 2014 cover page Mechanistic insights into hydride transfer for

  16. User Submitted Research Citations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... in mimicking the functionality of the proton pathway in the hydrogenase enzymes. ... We show that their finding that the 3D magnetic field scales approximately as density0.65 can ...

  17. Submitting Organization Sandia National ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Summary Any product that advances the state of the art for small form factor, self-charging, wireless power sources has the potential to affect millions of people by enabling new ...

  18. abs.submitted.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

  19. User Submitted Research Citations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... NERSC repository: m2217 NERSC Resources Used Edison - Cray XC30, Hopper - Cray XE6, Carver Linux Cluster Brennan ChemComm 01 12 2016 Molecular Titanium-Hydroxamate Complexes as ...

  20. Submit IGPPS Proposals

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Staff Assistant Georgia D. Sanchez (505) 665-0855 Email The Institute of Geophysics, Planetary Physics and Signatures (IGPPS) at Los Alamos National Laboratory (LANL)...

  1. Submitting Organization Sandia National ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ...PS-PVP). 2-(4'-Hydroxybenzeneazo)benzoic acid (HBBA) was used as the HA. For a typical synthesis, we added a 2 wt % solution of HBBA in dioxane to a 2-4 wt % solution of PS-PVP in ...

  2. Submitting Organization Sandia National ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... of care and at lower cost than with the current diagnostic technologies, will ... In these devices an acoustic wave is launched from an interdig- ital transducer (IDT) on ...

  3. ABSTRACTS FOR PAPERS SUBMITTED

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Partonic Effects on Pion Interferometry in Relativistic Heavy Ion Collisions Z. W. Lin, C. ... we study the pion interferometry at the Relativistic Heavy Ion Collider (RHIC). ...

  4. Submitting Batch Jobs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The following batch script requests 8 cores on 2 nodes with a 10 minute wall clock limit ... runs since it is the user's intention to exceed wall clock limit for the first job. ...

  5. Submitting Batch Jobs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... PBSOHOST Hostname of system on which qsub was executed. This is typically a Carver login node. PBSJOBID Unique identifier for this job; important for tracking job status. ...

  6. Submitting Organization Sandia National ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... CANARY is a software package that performs on-line, ... physical and cyber components of water distribution systems robust ... chlorine levels, pH, electrical conductivity, etc.). ...

  7. Energy and Water Development Appropriation Bill, 1985. Report submitted by Committee on Appropriations, House of Representatives, Ninety-Eighth Congress, Second Session

    SciTech Connect (OSTI)

    Not Available

    1984-01-01

    The House Committee on Appropriations summarizes the status of 1984 appropriations for 1984 and submits its estimates and recommendations for 1985 appropriations for the Departments of Defense (Civil), Interior, and Energy and for independent agencies. The estimated budget for Title I through IV items is $15.9 trillion, compared to $14.5 trillion in 1984. The committee recommends $15.5 trillion. The report reviews the budgets in each category and summarizes the hearings.

  8. Categorical Exclusion Determinations: A1 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Categorical Exclusion Determinations: A1 Existing Regulations A1: Routine DOE business actions Routine actions necessary to support the normal conduct of DOE business limited to administrative, financial, and personnel actions. Previous Regulations Categorical Exclusion Determinations dated before November 14th, 2011 were issued under previous DOE NEPA regulations. See the Notice of Final Rulemaking (76 FR 63763, 10/13/2011) for information changes to this categorical exclusion. DOCUMENTS

  9. Consumer Refrigerators-Freezers (Appendix A1) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Refrigerators-Freezers (Appendix A1) Consumer Refrigerators-Freezers (Appendix A1) The Department of Energy (DOE) develops standardized data templates for reporting the results of tests conducted in accordance with current DOE test procedures. Templates may be used by third-party laboratories under contract with DOE that conduct testing in support of ENERGY STAR® verification, DOE rulemakings, and enforcement of the federal energy conservation standards. Consumer Refrigerators-Freezers Appendix

  10. Evaluation of LLTR Series II tests A-1A and A-1B test results. [Large Leak Test Rig

    SciTech Connect (OSTI)

    Shoopak, B F; Amos, J C; Norvell, T J

    1980-03-01

    The standard methodology, with minor modifications provides conservative yet realistic predictions of leaksite and other sodium system pressures in the LLTR Series II vessel and piping. The good agreement between predicted and measured pressures indicates that the TRANSWRAP/RELAP modeling developed from the Series I tests is applicable to larger scale units prototypical of the Clinch River steam generator design. Calculated sodium system pressures are sensitive to several modeling parameters including rupture disc modeling, acoustic velocity in the test vessel, and flow rate from the rupture tube. The acoustic velocity which produced best agreement with leaksite pressures was calculated based on the shroud diameter and shroud wall thickness. The corresponding rupture tube discharge coefficient was that of the standard design methodology developed from Series I testing. As found in Series I testing, the Series II data suggests that the leading edge of the flow in the relief line is two phase for a single, doubled-ended guillotine tube rupture. The steam generator shroud acts as if it is relatively transparent to the transmission of radial pressures to the vessel wall. Slightly lower sodium system maximum pressures measured during Test A-1b compared to Test A-1a are attributed to premature failure (failure at a lower pressure) of the rupture disc in contact with the sodium for test A-1b. The delay in failure of the second disc in Test A-1b, which was successfully modeled with TRANSWRAP, is attributed to the limited energy in the nitrogen injection.

  11. Submitting MIGS, MIMS, MIENS Information to EMBL and Standards and the Sequencing Pipelines of the Gordon and Betty Moore Foundation (GSC8 Meeting)

    ScienceCinema (OSTI)

    Vaughan, Bob [EMBL]; Kaye, Jon [Gordon and Betty Moore Foundation

    2011-04-29

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Bob Vaughan of EMBL on submitting MIGS/MIMS/MIENS information to EMBL-EBI's system, followed by a brief talk from Jon Kaye of the Gordon and Betty Moore Foundation on standards and the foundation's sequencing pipelines at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 9, 2009

  12. A 1-Joule laser for a 16-fiber injection system

    SciTech Connect (OSTI)

    Honig, J

    2004-04-06

    A 1-J laser was designed to launch light down 16, multi-mode fibers (400-{micro}m-core dia.). A diffractive-optic splitter was designed in collaboration with Digital Optics Corporation (DOC), and was delivered by DOC. Using this splitter, the energy injected into each fiber varied <1%. The spatial profile out of each fiber was such that there were no ''hot spots,'' a flyer could successfully be launched and a PETN pellet could be initiated. Preliminary designs of the system were driven by system efficiency where a pristine TEM{sub 00} laser beam would be required. The laser is a master oscillator, power amplifier (MOPA) consisting of a 4-mm-dia. Nd:YLF rod in the stable, q-switched oscillator and a 9.5-mm-dia. Nd:YLF rod in the double-passed amplifier. Using a TEM{sub 00} oscillator beam resulted in excellent transmission efficiencies through the fibers at lower energies but proved to be quite unreliable at higher energies, causing premature fiber damage, flyer plate rupture, stimulated Raman scattering (SRS), and stimulated Brillouin scattering (SBS). Upon further investigation, it was found that both temporal and spatial beam formatting of the laser were required to successfully initiate the PETN. Results from the single-mode experiments, including fiber damage, SRS and SBS losses, will be presented. In addition, results showing the improvement that can be obtained by proper laser beam formatting will also be presented.

  13. A Proposal submitted to Biological Systems Science Division of DOE requesting Participant Support Costs for the Fifth International Conference on Polar and Alpine Microbiology

    SciTech Connect (OSTI)

    Priscu, John

    2012-11-20

    The 5th International Conference on Polar and Alpine Microbiology (PAM5) was held in Big Sky, Montana (USA) from 8-12 September 2013. This meeting is a continuation of the highly successful meetings previously held in Rovaniemi, Finland (2004), Innsbruck, Austria (2006), Banff, Canada (2008) and Ljubljana, Slovenia (2011), which brought together leading international researchers and students in this field. The objectives of the Big Sky meeting were to bring together scientists, students and professionals to discuss all aspects of cold-adapted microorganisms and the roles they play in polar and alpine environments, to understand the role of these organisms in our search for life on other icy worlds, to address recent developments, and to exchange ideas and experiences on an international scale. The conference provided a multi-disciplinary forum to explore emerging areas in the field and as always, will have a wealth of opportunities for the exchange of ideas and building of collaborations. Funds were requested to help defray registration fees and travel costs of 13 early career scientists. Distribution of the funds were based on the quality of the abstracts submitted.

  14. To be submitted to: Rev

    Office of Scientific and Technical Information (OSTI)

    ... Figure 1 illustrates the CSAF surface with three components in red, green and blue with a ... these channels are marked with red circles in Figure 6. The conversion values ...

  15. Submitted to Acta Cryst. E

    Office of Scientific and Technical Information (OSTI)

    Division of Lawrence Berkeley, National Laboratory, University of California, Berke- ley, California 94720, and b College of Chemistry, University of California at Berkeley, ...

  16. Submitting Organization Sandia National Laboratories

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    P.O. Box 5800 Albuquerque, NM 87185 Susan Brozik Address: P.O. Box 5800, MS 0892 City/State: Albuquerque, NM Zip/Postal Code: 87185 Country: USA Phone: 505-844-5105 Fax: 505-845-8161 smbrozi@sandia.gov Contact Person Glenn Kubiak Sandia National Laboratories Director, Biological and Materials Science Center Address: 7011 East Avenue, MS 9405 City/State: Livermore, CA Zip/Postal Code: 94551 Country: USA Phone: 925-294-3375 Fax: 925-294-3403 Email: kubiak@sandia.gov Joint Entry University of New

  17. Submitting Organization Sandia National Laboratories

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hongyou Fan Advanced Materials Laboratory 1001 University Boulevard SE Albuquerque, NM 87106 Country: USA Phone: 505-272-7128 Fax: 505-272-7336 hfan@sandia.gov Contact Person Glenn D. Kubiak, Director Sandia National Laboratories PO Box 969 Mail Stop 9405 Livermore, CA 94551-0969 USA Phone: 925-294-3375 Fax: 925- 294-3403 kubiak@sandia.gov Joint Entry Lockheed Martin Aeronautics Mail Zone 2893, PO Box 748 City: Fort Worth, Texas 76101 USA Earl Stromberg Phone: (817) 763-7376 Fax: (817) 762-6911

  18. Submitting Organization Sandia National Laboratories

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Todd Bauer Sandia National Laboratories. P.O. Box 5800, MS 1077 Albuquerque, NM 87185-1077 USA Phone:: (505)-845-0086 Fax:: (505) 844-7833 tmbaue@sandia.gov Contact Person Glenn D. Kubiak, Director, Biological and Materials Sciences Center Sandia National Laboratories PO Box 969 Mail Stop 9405 Livermore, CA 94551-0969, USA Phone:: 925-294-3375 Fax:: 925-294-3403 kubiak@sandia.gov Joint Entry: Front Edge Technology, Inc. 13455 Brooks Drive Baldwin Park, CA 91706 Submitter Simon Nieh Front Edge

  19. Submitting Organization Sandia National Laboratories

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sean A. McKenna, PhD Distinguished Member of the Technical Staff P.O. Box 5800 MS 0751 Albuquerque, NM 87185-0185 Phone (505) 844-2450 Fax (505) 844-7354 samcken@sandia.gov Contact Person Glenn D. Kubiak Director, Biological and Materials Sciences Center Sandia National Laboratories PO Box 969 MS 9405 Livermore, CA 94551-0969 USA Phone (925) 294-3375 Fax (925) 294-3403 kubiak@sandia.gov Joint Entry with U. S. Environmental Protection Agency 26 W Martin Luther King Dr. (NG 16) Cincinnati, Ohio

  20. To be submitted to Appl

    Office of Scientific and Technical Information (OSTI)

    retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide ...

  1. AARP submits the following comments on consumers and smart grid issues in response to the Request for Information (Request or RFI) on smart grid policy and logistical challenges, published by the Department of Energy (DOE) on September 16, 2010

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AARP, National Consumer Law Center, and Public Citizen Comments to: DEPARTMENT OF ENERGY Smart Grid RFI: Addressing Policy and Logistical Challenges David Certner Legislative Counsel and Legislative Policy Director AARP Government Relations and Advocacy Olivia Wein, Staff Attorney National Consumer Law Center Tyson Slocum, Director Public Citizen's Energy Program November 1, 2010 2 CONSUMER COMMENTERS: AARP, National Consumer Law Center, and Public Citizen submit the following comments on

  2. Wave-Energy/-Device Modeling: Developing A 1:17 Scaled Model

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... News & Events, Renewable Energy, Research & Capabilities, Systems Analysis, Water PowerWave-Energy-Device Modeling: Developing A 1:17 Scaled Model Wave-Energy-Device Modeling: ...

  3. Table A1. Refiner/Reseller Motor Gasoline Prices by Grade, PAD...

    U.S. Energy Information Administration (EIA) Indexed Site

    Information Administration Petroleum Marketing Annual 1995 Table A1. RefinerReseller Motor Gasoline Prices by Grade, PAD District and State, 1984-Present (Cents per Gallon...

  4. Table A1. Refiner/Reseller Motor Gasoline Prices by Grade, PAD...

    U.S. Energy Information Administration (EIA) Indexed Site

    AdministrationPetroleum Marketing Annual 1999 401 Table A1. RefinerReseller Motor Gasoline Prices by Grade, PAD District and State, 1984-Present (Cents per Gallon...

  5. ,"Table 3A.1. January Monthly Peak Hour Demand, by North American...

    U.S. Energy Information Administration (EIA) Indexed Site

    A.1. January Monthly Peak Hour Demand, by North American Electric Reliability Corporation ... February Monthly Peak Hour Demand, by North American Electric Reliability Corporation ...

  6. Axial resonances a$$_{1}$$(1260), b$$_{1}$$(1235) and their decays from the lattice

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lang, C. B.; Leskovec, Luka; Mohler, Daniel; Prelovsek, Sasa

    2014-04-28

    The light axial-vector resonancesmore » $a_1(1260)$ and $b_1(1235)$ are explored in Nf=2 lattice QCD by simulating the corresponding scattering channels $$\\rho\\pi$$ and $$\\omega\\pi$$. Interpolating fields $$\\bar{q} q$$ and $$\\rho\\pi$$ or $$\\omega\\pi$$ are used to extract the s-wave phase shifts for the first time. The $$\\rho$$ and $$\\omega$$ are treated as stable and we argue that this is justified in the considered energy range and for our parameters $$m_\\pi\\simeq 266~$$MeV and $$L\\simeq 2~$$fm. We neglect other channels that would be open when using physical masses in continuum. Assuming a resonance interpretation a Breit-Wigner fit to the phase shift gives the $a_1(1260)$ resonance mass $$m_{a1}^{res}=1.435(53)(^{+0}_{-109})$$ GeV compared to $$m_{a1}^{exp}=1.230(40)$$ GeV. The $a_1$ width $$\\Gamma_{a1}(s)=g^2 p/s$$ is parametrized in terms of the coupling and we obtain $$g_{a_1\\rho\\pi}=1.71(39)$$ GeV compared to $$g_{a_1\\rho\\pi}^{exp}=1.35(30)$$ GeV derived from $$\\Gamma_{a1}^{exp}=425(175)$$ MeV. In the $b_1$ channel, we find energy levels related to $$\\pi(0)\\omega(0)$$ and $b_1(1235)$, and the lowest level is found at $$E_1 \\gtrsim m_\\omega+m_\\pi$$ but is within uncertainty also compatible with an attractive interaction. Lastly, assuming the coupling $$g_{b_1\\omega\\pi}$$ extracted from the experimental width we estimate $$m_{b_1}^{res}=1.414(36)(^{+0}_{-83})$$.« less

  7. A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin...

    Office of Scientific and Technical Information (OSTI)

    Ion-binding Step Citation Details In-Document Search Title: A 1.3- Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates Potential Early Ion-binding Step Authors: ...

  8. Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human...

    Office of Scientific and Technical Information (OSTI)

    human HepG2 hepatoma cell line Citation Details In-Document Search Title: Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line Diterpenoid ...

  9. File:FormA1-R.pdf | Open Energy Information

    Open Energy Info (EERE)

    link to this file. Retrieved from "http:en.openei.orgwindex.php?titleFile:FormA1-R.pdf&oldid532769" Feedback Contact needs updating Image needs updating Reference...

  10. Refrigerators and Refrigerator-Freezers (Appendix A1 after May 2, 2011) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Refrigerators and Refrigerator-Freezers (Appendix A1 after May 2, 2011) Refrigerators and Refrigerator-Freezers (Appendix A1 after May 2, 2011) The Department of Energy (DOE) develops standardized data templates for reporting the results of tests conducted in accordance with current DOE test procedures. Templates may be used by third-party laboratories under contract with DOE that conduct testing in support of ENERGY STAR® verification, DOE rulemakings, and enforcement

  11. Table A1. Refiner/Reseller Motor Gasoline Prices by Grade, PAD...

    U.S. Energy Information Administration (EIA) Indexed Site

    71.6 92.3 78.2 101.8 83.6 87.5 74.7 See footnotes at end of table. A1. RefinerReseller Motor Gasoline Prices by Grade, PAD District, and State, 1984-Present 452 Energy Information...

  12. Higgs Coupling Measurements at a 1 TeV Linear Collider

    SciTech Connect (OSTI)

    Barklow, T

    2003-12-18

    Methods for extracting Higgs boson signals at a 1 TeV center-of-mass energy e{sup +}e{sup -} linear collider are described. In addition, estimates are given for the accuracy with which branching fractions can be measured for Higgs boson decays to b{bar b} WW, gg, and {gamma}{gamma}.

  13. Neutron dosimetry and damage calculations for the ATR-A1 irradiation

    SciTech Connect (OSTI)

    Greenwood, L.R.; Ratner, R.T.

    1998-09-01

    Neutron fluence measurements and radiation damage calculations are reported for the collaborative US/Japan ATR-A1 irradiation in the Advanced Test Reactor (ATR) at Idaho National Engineering Laboratory (INEL). The maximum total neutron fluence at midplane was 9.4 {times} 10{sup 21} n/cm{sup 2} (5.5 {times} 10{sup 21} n/cm{sup 2} above 0.1 MeV), resulting in about 4.6 dpa in vanadium.

  14. Active site proton delivery and the lyase activity of human CYP17A1

    SciTech Connect (OSTI)

    Khatri, Yogan; Gregory, Michael C.; Grinkova, Yelena V.; Denisov, Ilia G.; Sligar, Stephen G.

    2014-01-03

    Highlights: The disruption of PREG/PROG hydroxylation activity by T306A showed the participation of Cpd I. T306A supports the involvement of a nucleophilic peroxo-anion during lyase activity. The presence of cytochrome b{sub 5} augments CC lyase activity. ?5-Steroids are preferred substrates for CYP17 catalysis. -- Abstract: Cytochrome P450 CYP17A1 catalyzes a series of reactions that lie at the intersection of corticoid and androgen biosynthesis and thus occupies an essential role in steroid hormone metabolism. This multifunctional enzyme catalyzes the 17?-hydroxylation of ?4- and ?5-steroids progesterone and pregnenolone to form the corresponding 17?-hydroxy products through its hydroxylase activity, and a subsequent 17,20-carboncarbon scission of pregnene-side chain produce the androgens androstenedione (AD) and dehydroepiandrosterone (DHEA). While the former hydroxylation reaction is believed to proceed through a conventional Compound I rebound mechanism, it has been suggested that the latter carbon cleavage is initiated by an iron-peroxy intermediate. We report on the role of Thr306 in CYP17 catalysis. Thr306 is a member of the conserved acid/alcohol pair thought to be essential for the efficient delivery of protons required for hydroperoxoanion heterolysis and formation of Compound I in the cytochromes P450. Wild type and T306A CYP17A1 self-assembled in Nanodiscs were used to quantitate turnover and coupling efficiencies of CYP17s physiological ?4- and ?5-substrates. We observed that T306A co-incorporated in Nanodiscs with its redox partner cytochrome P450 oxidoreductase, coupled NADPH only by 0.9% and 0.7% compared to the wild type (97% and 22%) during the conversion of pregnenolone and progesterone, respectively, to the corresponding 17-OH products. Despite increased oxidation of pyridine nucleotide, hydroxylase activity was drastically diminished in the T306A mutant, suggesting a high degree of uncoupling in which reducing equivalents and protons

  15. Measurement of velocity deficit at the downstream of a 1:10 axial hydrokinetic turbine model

    SciTech Connect (OSTI)

    Gunawan, Budi; Neary, Vincent S; Hill, Craig; Chamorro, Leonardo

    2012-01-01

    Wake recovery constrains the downstream spacing and density of turbines that can be deployed in turbine farms and limits the amount of energy that can be produced at a hydrokinetic energy site. This study investigates the wake recovery at the downstream of a 1:10 axial flow turbine model using a pulse-to-pulse coherent Acoustic Doppler Profiler (ADP). In addition, turbine inflow and outflow velocities were measured for calculating the thrust on the turbine. The result shows that the depth-averaged longitudinal velocity recovers to 97% of the inflow velocity at 35 turbine diameter (D) downstream of the turbine.

  16. How to Submit Forms: Exclusionary List:

    U.S. Energy Information Administration (EIA) Indexed Site

    See PART 3 of the instructions. 2 4 Permanently ceased operation. See PART 3 of the ... Comments: (To separate one comment from another, press ALT+ENTER) In operation Temporarily ...

  17. Submitting Organization Hongyou Fan Sandia National Laboratories

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... for instance, fabrication of the gold nanoparticlesilica nanocomposite (see ... involving hopping of electrons from one gold nanocrystal to another within the coating, ...

  18. ARM - Instructions for Submitting Extended Abstracts

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Graphics should be sent as individual graphic files in their original software and NOT placed within the abstract. Createsize graphics to fit the image area. Make sure that any...

  19. Microsoft Word - Dissertation_CMH_submit.docx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    under most similar environmental condition to the current test. 11 1.5.3. Sparse Array Signal Processing In designing a sensor system to acquire UGW data from a structure,...

  20. To be submitted to (Science, Nature Materials)

    Office of Scientific and Technical Information (OSTI)

    ... effect in correlated oxide systems. Nature 424, 1015-1018 (2003). 24 Ievlev, A. V. et al. ... Nature Communication (in press). 28 Hardle, W. & Simar, L. Applied Multivariate ...

  1. UTILITY Submit to BPA: Upload Template

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    achieved. (mmddyyyy) Was measure installed in a federal facility? (Dropdown box below) Utility assigned end user account or member number. Maximum length 50 characters....

  2. Property:Date Submitted | Open Energy Information

    Open Energy Info (EERE)

    + 20150925 + MHK TechnologiesCentipod + 02:03.7 + MHK TechnologiesClosed Cycle OTEC + 02:50.8 + MHK TechnologiesCoRMaT + 15:58.3 + (previous 25) (next 25) Retrieved from...

  3. Strategic Plan Submitted to the Secretary

    Broader source: Energy.gov (indexed) [DOE]

    Exploration | Department of Energy Stochastic Joint Inversion for Integrated Data Interpretation in Geothermal Exploration presentation at the April 2013 peer review meeting held in Denver, Colorado. mellors_peer2013.pdf (607.26 KB) More Documents & Publications track 2: hydrothermal | geothermal 2015 peer review Imaging, Characterizing, and Modeling of Fracture Networks and Fluid Flow in EGS Reservoirs Use of Geophysical Techniques to Characterize Fluid Flow in a Geothermal Reservoir

  4. Microsoft Word - Final Report-submitted.docx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    component of the Starbucks mission and in reported energy saving behavior. Key Lessons Learned Clear predictors of store success were supportive management, a strong...

  5. WIPP - How to submit a FOIA request

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Liaison U.S. Department of Energy Carlsbad Field Office P.O. Box 3090 4021 National Parks Highway Carlsbad, New Mexico 88221-3090 foialiaison@ FOIA requests may be mailed or...

  6. Overview of Remote Handling Equipment Used for the NPP A1 Decommissioning - 12141

    SciTech Connect (OSTI)

    Kravarik, K.; Medved, J.; Pekar, A.; Stubna, M.; Michal, V.; Vargovcik, L.

    2012-07-01

    The first Czechoslovak NPP A1 was in operation from 1972 to 1977 and it was finally shutdown due to an accident (level 4 according to the INES). The presence of radioactive, toxic or hazardous materials limits personnel access to facilities and therefore it is necessary to use remote handling technologies for some most difficult characterization, retrieval, decontamination and dismantling tasks. The history of remote handling technologies utilization started in nineties when the spent nuclear fuel, including those fuel assemblies damaged during the accident, was prepared for the transport to Russia. Subsequent significant development of remote handling equipment continued during implementation of the NPP A1 decommissioning project - Stage I and ongoing Stage II. Company VUJE, Inc. is the general contractor for both mentioned stages of the decommissioning project. Various remote handling manipulators and robotics arms were developed and used. It includes remotely controlled vehicle manipulator MT-15 used for characterisation tasks in hostile and radioactive environment, special robust manipulator DENAR-41 used for the decontamination of underground storage tanks and multi-purposes robotics arms MT-80 and MT-80A developed for variety of decontamination and dismantling tasks. The heavy water evaporator facility dismantling is the current task performed remotely by robotics arm MT-80. The heavy water evaporator is located inside the main production building in the room No. 220 where loose surface contamination varies from 10 Bq/cm{sup 2} to 1x10{sup 3} Bq/cm{sup 2}, dose rate is up to 1.5 mGy/h and the feeding pipeline contained liquid RAW with high tritium content. Presented manipulators have been designed for broad range of decommissioning tasks. They are used for recognition, sampling, waste retrieval from large underground tanks, decontamination and dismantling of technological equipments. Each of the mentioned fields claims specific requirements on design of

  7. Test of a 1.8 Tesla, 400 Hz Dipole for a Muon Synchrotron

    SciTech Connect (OSTI)

    Summers, D.J.; Cremaldi, L.M.; Hart, T.L.; Perera, L.P.; Reep, M.; Witte, H.; Hansen, S.; Lopes, M.L.; Reidy Jr., J.; /Oxford High School

    2012-05-01

    A 1.8 T dipole magnet using thin grain oriented silicon steel laminations has been constructed as a prototype for a muon synchrotron ramping at 400 Hz. Following the practice in large 3 phase transformers and our own Opera-2d simulations, joints are mitred to take advantage of the magnetic properties of the steel which are much better in the direction in which the steel was rolled. Measurements with a Hysteresigraph 5500 and Epstein frame show a high magnetic permeability which minimizes stored energy in the yoke allowing the magnet to ramp quickly with modest voltage. Coercivity is low which minimizes hysteresis losses. A power supply with a fast Insulated Gate Bipolar Transistor (IGBT) switch and a capacitor was constructed. Coils are wound with 12 gauge copper wire. Thin wire and laminations minimize eddy current losses. The magnetic field was measured with a peak sensing Hall probe.

  8. Laser photodetachment diagnostics of a 1/3-size negative hydrogen ion source for NBI

    SciTech Connect (OSTI)

    Geng, S.; Tsumori, K.; Nakano, H.; Kisaki, M.; Ikeda, K.; Takeiri, Y.; Osakabe, M.; Nagaoka, K.; Kaneko, O.

    2015-04-08

    To investigate the flows of charged particles in front of the plasma grid (PG) in a negative hydrogen ion source, the information of the local densities of electrons and negative hydrogen ions (H-) are necessary. For this purpose, the laser photodetachment is applied for pure hydrogen plasmas and Cs-seeded plasma in a 1/3-size negative hydrogen ion source in NIFS-NBI test stand. The H- density obtained by photodetachment is calibrated by the results from cavity ring-down (CRD). The pressure dependence and PG bias dependence of the local H- density are presented and discussed. The results show that H- density increases significantly by seeding Cs into the plasma. In Cs-seeded plasma, relativity exists between the H- ion density and plasma potential.

  9. Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism

    SciTech Connect (OSTI)

    Shields, P.G.; Bowman, E.D.; Weston, A.; Harris, C.C.; Sugimura, H.; Caporaso, N.E.; Petruzzelli, S.F. ); Trump, B.F. )

    1992-11-01

    Human cancer risk assessment at a genetic level involves the investigation of carcinogen metabolism and DNA adduct formation. Wide interindividual differences in metabolism result in different DNA adduct levels. For this and other reasons, many laboratories have considered DNA adducts to be a measure of the biologically effective dose of a carcinogen. Techniques for studying DNA adducts using chemically specific assays are becoming available. A modification of the [sup 32]P-postlabeling assay for polycyclic aromatic hydrocarbon DNA adducts described here provides potential improvements in quantification. DNA adducts, however, reflect only recent exposure to carcinogens; in contrast, genetic testing for metabolic capacity indicates the extent to which carcinogens can be activated and exert genotoxic effects. Such studies may reflect both separate and integrated risk factors together with DNA adduct levels. A recently described restriction fragment length polymorphism for the CYP1A1, which codes for the cytochrome P450 enzyme primarily responsible for the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons, has been found to be associated with lung cancer risk in a Japanese population. In a subset of individuals enrolled in a US lung cancer case-control study, no association with lung cancer was found. 17 refs., 3 figs.

  10. Daymet: Daily Surface Weather Data on a 1-km Grid for North America, Version 2.

    SciTech Connect (OSTI)

    Thornton, Peter E; Thornton, Michele M; Mayer, Benjamin W; Wilhelmi, Nate; Wei, Yaxing; Devarakonda, Ranjeet; Cook, Robert B

    2014-01-01

    More information: http://daymet.ornl.gov Presenter: Ranjeet Devarakonda Environmental Sciences Division Oak Ridge National Laboratory (ORNL) Daymet: Daily Surface Weather Data and Climatological Summaries provides gridded estimates of daily weather parameters for North America, including daily continuous surfaces of minimum and maximum temperature, precipitation occurrence and amount, humidity, shortwave radiation, snow water equivalent, and day length. The current data product (Version 2) covers the period January 1, 1980 to December 31, 2013 [1]. The prior product (Version 1) only covered from 1980-2008. Data are available on a daily time step at a 1-km x 1-km spatial resolution in Lambert Conformal Conic projection with a spatial extent that covers the conterminous United States, Mexico, and Southern Canada as meteorological station density allows. Daymet data can be downloaded from 1) the ORNL Distributed Active Archive Center (DAAC) search and order tools (http://daac.ornl.gov/cgi-bin/cart/add2cart.pl?add=1219) or directly from the DAAC FTP site (http://daac.ornl.gov/cgi-bin/dsviewer.pl?ds_id=1219) and 2) the Single Pixel Tool [2] and THREDDS (Thematic Real-time Environmental Data Services) Data Server [3]. The Single Pixel Data Extraction Tool allows users to enter a single geographic point by latitude and longitude in decimal degrees. A routine is executed that translates the (lon, lat) coordinates into projected Daymet (x,y) coordinates. These coordinates are used to access the Daymet database of daily-interpolated surface weather variables. Daily data from the nearest 1 km x 1 km Daymet grid cell are extracted from the database and formatted as a table with one column for each Daymet variable and one row for each day. All daily data for selected years are returned as a single (long) table, formatted for display in the browser window. At the top of this table is a link to the same data in a simple comma-separated text format, suitable for import into a

  11. Experimental results from pressure testing a 1:6-scale nuclear power plant containment

    SciTech Connect (OSTI)

    Horschel, D.S.

    1992-01-01

    This report discusses the testing of a 1:6-scale, reinforced-concrete containment building at Sandia National Laboratories, in Albuquerque, New Mexico. The scale-model, Light Water Reactor (LWR) containment building was designed and built to the American Society of Mechanical Engineers (ASME) code by United Engineers and Constructors, Inc., and was instrumented with over 1200 transducers to prepare for the test. The containment model was tested to failure to determine its response to static internal overpressurization. As part of the US Nuclear Regulatory Commission`s program on containment integrity, the test results will be used to assess the capability of analytical methods to predict the performance of containments under severe-accident loads. The scaled dimensions of the cylindrical wall and hemispherical dome were typical of a full-size containment. Other typical features included in the heavily reinforced model were equipment hatches, personnel air locks, several small piping penetrations, and a ihin steel liner that was attached to the concrete by headed studs. In addition to the transducers attached to the model, an acoustic detection system and several video and still cameras were used during testing to gather data and to aid in the conduct of the test. The model and its instrumentation are briefly discussed, and is followed by the testing procedures and measured response of the containment model. A summary discussion is included to aid in understanding the significance of the test as it applies to real world reinforced concrete containment structures. The data gathered during SIT and overpressure testing are included as an appendix.

  12. An early look of comet C/2013 A1 (Siding Spring): Breathtaker or nightmare?

    SciTech Connect (OSTI)

    Ye, Quan-Zhi; Hui, Man-To

    2014-06-01

    The dynamically new comet, C/2013 A1 (Siding Spring), is to make a close approach to Mars on 2014 October 19 at 18:30 UT at a distance of 40 1 Martian radii. Such an extremely rare event offers a precious opportunity for the spacecrafts on Mars to closely study a dynamically new comet itself as well as the planet-comet interaction. Meanwhile, the high-speed meteoroids released from C/Siding Spring also pose a threat to physically damage the spacecrafts. Here we present our observations and modeling results of C/Siding Spring to characterize the comet and assess the risk posed to the spacecrafts on Mars. We find that the optical tail of C/Siding Spring is dominated by larger particles at the time of the observation. Synchrone simulation suggests that the comet was already active in late 2012 when it was more than 7 AU from the Sun. By parameterizing the dust activity with a semi-analytic model, we find that the ejection speed of C/Siding Spring is comparable to comets such as the target of the Rosetta mission, 67P/Churyumov-Gerasimenko. Under a nominal situation, the simulated dust cone will miss the planet by about 20 Martian radii. At the extreme ends of uncertainties, the simulated dust cone will engulf Mars, but the meteoric influx at Mars is still comparable to the nominal sporadic influx, seemly indicating that an intense and enduring meteoroid bombardment due to C/Siding Spring is unlikely. Further simulation also suggests that gravitational disruption of the dust tail may be significant enough to be observable at Earth.

  13. MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1

    SciTech Connect (OSTI)

    Ziaei, Samira; The Graduate School and University Center of CUNY, New York, NY ; Shimada, Naoko; Kucharavy, Herman; Hubbard, Karen; The Graduate School and University Center of CUNY, New York, NY

    2012-03-10

    Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an RNA-binding protein that modulates splice site usage, polyadenylation, and cleavage efficiency. This protein has also been implicated in mRNA stability and transport from the nucleus. We have previously demonstrated that hnRNP A1 had diminished protein levels and showed cytoplasmic accumulation in senescent human diploid fibroblasts. Furthermore, we have shown that inhibition of p38 MAPK, a key regulator of cellular senescence, elevated hnRNP A1 protein levels and inhibited hnRNP A1 cytoplasmic localization. In this study, we have explored the possible involvement of MNK1, one of the downstream effector of p38 MAPK, in the regulation of hnRNP A1. We have demonstrated that pharmacological inhibition of MNK1 by CGP 57380 decreased the phosphorylation levels of hnRNP A1 in young and senescent fibroblast cells and blocked the cytoplasmic accumulation of hnRNP A1 in senescent cells. In addition, MNK1 formed a complex with hnRNP A1 in vivo. The expression levels of MNK1, phospho-MNK1, and phospho-eIF4E proteins were found to be elevated in senescent cells. These data suggest that MNK1 regulates the phosphorylation and the subcellular distribution of hnRNP A1 and that MNK1 may play a role in the induction of senescence. -- Highlights: Black-Right-Pointing-Pointer MNK1 and not MAPKAPK2 phosphorylates hnRNP A1. Black-Right-Pointing-Pointer MNK1 has elevated levels in senescent cells, this has not been reported previously. Black-Right-Pointing-Pointer MNK1 activity induces cytoplasmic accumulation of hnRNP A1 in senescent cells. Black-Right-Pointing-Pointer Altered cytoplasmic localization of hnRNP A1 may alter gene expression patterns. Black-Right-Pointing-Pointer Our studies may increase our understanding of RNA metabolism during cellular aging.

  14. Review of the Y-1-12 Implementation Verification Review Processes...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    B-1 ii Acronyms AMOM Assistant Manager for Operations Management CAAS Criticality Accident ... by the Readiness Assurance Group within the Production Facilities Department. ...

  15. acs_nn_nn-2015-01170y 1..8

    Office of Scientific and Technical Information (OSTI)

    ... Phys. 2007, 102, 024913. 17. Arcenegui, J. J.; Garcia-Sanchez, P.; Morgan, H.; Ramos, A. Phys. Rev. E 2013, 88, 063018. 18. Jones, T. B. Electromechanics of Particles; Cambridge ...

  16. a1.xls

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    2003 Commercial Buildings Energy Consumption Survey Detailed Tables October 2006 Energy Information Administration 2003 Commercial Buildings Energy Consumption Survey Detailed...

  17. a1.xls

    U.S. Energy Information Administration (EIA) Indexed Site

    Principal Building Activity Education ...... 7.1 6.0 ... Principal Building Activity Education ...... 7.1 15.1 ...

  18. a1.xls

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    See "Guide to the Tables" or "Glossary" for further explanations of the terms used in this table. Both can be accessed from the CBECS web site http:www.eia.doe.govemeucbecs. ...

  19. a1.xls

    Gasoline and Diesel Fuel Update (EIA)

    Both can be accessed from the CBECS web site http:www.eia.doe.govemeucbecs. Note: Due ... Both can be accessed from the CBECS web site http:www.eia.doe.govemeucbecs. QData ...

  20. Microstructural examination of V-(3-6%)Cr-(3-5%)Ti irradiated in the ATR-A1 experiment

    SciTech Connect (OSTI)

    Gelles, D.S.

    1998-09-01

    Microstructural examination results are reported for four heats of V-(3-6%)Cr-(3-5%)Ti irradiated in the ATR-A1 experiment to {approximately}4 dpa at {approximately}200 and 300 C to provide an understanding of the microstructural evolution that may be associated with degradation of mechanical properties. Fine precipitates were observed in high density intermixed with small defect clusters for all conditions examined following the irradiation. The irradiation-induced precipitation does not appear to be affected by preirradiation heat treatment or composition.

  1. Osteogenesis imperfecta type I: Molecular heterogeneity for COL1A1 null alleles of type I collagen

    SciTech Connect (OSTI)

    Willing, M.C.; Deschenes, S.P.; Pitts, S.H.; Arikat, H.; Roberts, E.J.; Scott, D.A.; Slayton, R.L.; Byers, P.H.

    1994-10-01

    Osteogenesis imperfecta (OI) type I is the mildest form of inherited brittle-bone disease. Dermal fibroblasts from most affected individuals produce about half the usual amount of type I procollagen, as a result of a COL1A1 {open_quotes}null{close_quotes} allele. Using PCR amplification of genomic DNA from affected individuals, followed by denaturing gradient gel electrophoresis (DGGE) and SSCP, we identified seven different COL1A1 gene mutations in eight unrelated families with OI type I. Three families have single nucleotide substitutions that alter 5{prime} donor splice sites; two of these unrelated families have the same mutation. One family has a point mutation, in an exon, that creates a premature termination codon, and four have small deletions or insertions, within exons, that create translational frameshifts and new termination codons downstream of the mutation sites. Each mutation leads to both marked reduction in steady-state levels of mRNA from the mutant allele and a quantitative decrease in type I procollagen production. Our data demonstrate that different molecular mechanisms that have the same effect on type I collagen production result in the same clinical phenotype. 58 refs., 4 figs., 1 tab.

  2. Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wright, Aaron T.; Magnaldo, Thierry; Sontag, Ryan L.; Anderson, Lindsey N.; Sadler, Natalie C.; Piehowski, Paul D.; Gache, Yannick; Weber, Thomas J.

    2013-11-27

    Human phenotypes that are highly susceptible to radiation carcinogenesis have been identified. Sensitive phenotypes often display robust regulation of molecular features that modify biological response, which can facilitate identification of relevant pathways/networks. Here we interrogate primary dermal fibroblasts isolated from Gorlin syndrome patients (GDFs), who display a pronounced tumorigenic response to radiation, in comparison to normal human dermal fibroblasts (NHDFs). Our approach exploits newly developed thiol-reactive probes with a flexible click chemistry functional group to define changes in protein thiol profiles in live cell studies, which minimizes artifacts associated with cell lysis. We observe qualitative differences in protein thiol profilesmore » by SDS-PAGE analysis when detection by iodoacetamide vs maleimide probe chemistries are compared, and pretreatment of cells with hydrogen peroxide eliminates detection of the majority of SDS-PAGE bands. Redox probes revealed deficient expression of an apparent 55 kDa protein thiol in GDFs from independent donors, compared with NHDFs. Proteomics tentatively identified this protein as aldehyde dehydrogenase 1A1 (ALDH1A1), a key enzyme regulating retinoic acid synthesis, and this deficiency was confirmed by Western blot. Redox probes revealed additional protein thiol differences between GDFs and NHDFs, including radiation responsive annexin family members. Our results indicate a multifactorial basis for the unusual sensitivity of Gorlin syndrome to radiation carcinogenesis, and the pathways identified have plausible implications for radiation health effects.« less

  3. Measurements of the Neutron Longitudinal Spin Asymmetry A1n and Flavor Decomposition in the Valence Quark Region

    SciTech Connect (OSTI)

    Flay, David J.

    2014-08-01

    The current data for the nucleon-virtual photon longitudinal spin asymmetry A1 on the proton and neutron have shown that the ratio of the polarized-to-unpolarized down-quarkparton distribution functions,Dd=d, tends towards -1/2 at large x, in disagreement with the perturbative QCD prediction that Dd/d approaches 1 but more in line with constituent quark models. As a part of experiment E06-014 in Hall A of Jefferson Lab, double-spin asymmetries were measured in the scattering of a longitudinally polarized electron beam of energies 4.74 and 5.89 GeV from a longitudinally and transversely polarized 3He target in the deep inelastic scattering and resonance region, allowing for the extraction of the neutron asymmetry An1 and the ratios Dd/d and Du/u. We will discuss our analysis of the data and present results for A1 and g1/F1 on both 3He and the neutron, and the resulting quark ratios for the up and down quarks in the kinematic range of 0.2

  4. Extreme Climate Event Trends: The Data Mining and Evaluation of the A1FI Scenario for 2000???2100

    SciTech Connect (OSTI)

    Erickson III, David J; Ganguly, Auroop R; Steinhaeuser, Karsten J K; Branstetter, Marcia L; Oglesby, Robert; Hoffman, Forrest M; Buja, Lawrence

    2008-01-01

    The authors discuss the implications and resulting alterations of the hydrologic cycle as Earth climate evolves from 2000-2100. Climate simulations based on the assumptions implicit in the A1F1 scenario for the period 2000-2100 using CCSM3 are analyzed. In particular, we will assess the changes in the surface latent and sensible heat energy budget, the Indian regional water budgets including trends in the timing and duration of the Indian monsoon and the resulting impacts on mean river flow and hydroelectric power generation potential. These analyses will also be examined within the context of heat index, droughts, floods and related estimates of societal robustness and resiliency. We will interpret these new A1F1 results within the context of the previous climate simulations based on the SRES A2 and B1 scenarios forced with land cover and atmospheric CO2. Analyses of historical records in the context of the Indian Monsoon Rainfall (IMR) have suggested an evolving relation of IMR with natural climate variability caused by El Nino events. We will report on the combined effects of natural climate variability and global warming on IMR and assess the trend of extreme rain and temperature events in a warming environment.

  5. Quantum lattice fluctuations in a 1-dimensional charge-density-wave material: Luminescence and resonance Raman studies

    SciTech Connect (OSTI)

    Long, F.H.; Love, S.P.; Swanson, B.I.

    1993-12-31

    Luminescence spectra, both emission and excitation, and the excitation dependence of the resonance Raman (RR) spectra have been measured for a 1-dimensional charge-density-wave solid, [Pt(L)CI{sub 2}][Pt(L)](CIO{sub 4}){sub 4}; L=1,2-diaminoethane. The luminescence experiments support the existence of tail states in the band gap region, which indicate the presence of disorder. In contrast, the RR measurements conclusively demonstrate that the effects of static structural disorder on the vibrational spectroscopy can be neglected. This apparently paradoxical result can be explained by considering the zero-point motion of the lattice. The experimental results are compared to recent theoretical models.

  6. Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells

    SciTech Connect (OSTI)

    Chen, Yue; Zhang, Shunfen; Zhou, Tianyan; Huang, Chaoqun; McLaughlin, Alicia; Chen, Guangping

    2013-04-15

    Cytosolic sulfotransferases are one of the major families of phase II drug metabolizing enzymes. Sulfotransferase-catalyzed sulfonation regulates hormone activities, metabolizes drugs, detoxifies xenobiotics, and bioactivates carcinogens. Human dehydroepiandrosterone sulfotransferase (hSULT2A1) plays important biological roles by sulfating endogenous hydroxysteroids and exogenous xenobiotics. Genistein, mainly existing in soy food products, is a naturally occurring phytoestrogen with both chemopreventive and chemotherapeutic potential. Our previous studies have shown that genistein significantly induces hSULT2A1 in Hep G2 and Caco-2 cells. In this study, we investigated the roles of liver X receptor (LXRα) in the genistein induction of hSULT2A1. LXRs have been shown to induce expression of mouse Sult2a9 and hSULT2A1 gene. Our results demonstrate that LXRα mediates the genistein induction of hSULT2A1, supported by Western blot analysis results, hSULT2A1 promoter driven luciferase reporter gene assay results, and mRNA interference results. Chromatin immunoprecipitation (ChIP) assay results demonstrate that genistein increase the recruitment of hLXRα binding to the hSULT2A1 promoter. These results suggest that hLXRα plays an important role in the hSULT2A1 gene regulation. The biological functions of phytoestrogens may partially relate to their induction activity toward hydroxysteroid SULT. - Highlights: ► Liver X receptor α mediated genistein induction of hSULT2A1 in Hep G2 cells. ► LXRα and RXRα dimerization further activated this induction. ► Western blot results agreed well with luciferase reporter gene assay results. ► LXRs gene silencing significantly decreased hSULT2A1 expression. ► ChIP analysis suggested that genistein enhances hLXRα binding to the hSULT2A1 promoter.

  7. Wake of the MOD-0A1 wind turbine at two rotor diameters downwind on December 3, 1981

    SciTech Connect (OSTI)

    Connell, J.R.; George, R.L.

    1982-11-01

    The wake of the MOD-0A1 wind turbine at Clayton, New Mexico has been measured using a vertical plane array of anemometers in a crosswind plane at a distance of two rotor diameters directly downwind of the turbine. Rotor blade vortices were well mixed into the wake turbulence and were not separately detectable. Wake swirl about the along-wind axis had a value not greater than 0.025 rad/s. Extra turbulence energy existed in the edge of the wake at a frequency of about n=0.025 Hz. The cross-wake plane analyses of wind speeds revealed a nearly circular inner portion and a strongly elliptical portion. The elliptical portion major axis was horizontal. An estimate of the average rate of reenergizing of the wake, using measurements of mean wind energy flow and turbine power, suggests that entrainment with ambient air may have been rapid. Some wake characteristics were compared with the corresponding ones for several simple wake models based upon concepts of mixing of ambient air into a wake or an equivalent coaxial jet. (LEW)

  8. A method distinguishing expressed vs. null mutations of the Col1A1 gene in osteogenesis imperfecta

    SciTech Connect (OSTI)

    Redford-Badwal, D.A.; Stover, M.L.; McKinstry, M.

    1994-09-01

    Osteogenesis imperfecta (OI) is a heterogeneous group of heritable disorders of bone characterized by increased susceptibility to fracture. Most of the causative mutations were identified in patients with the lethal form of the disease. Attention is now shifting to the milder forms of OI where glycine substitutions and null producing mutations have been found. Single amino acid substitutions can be identified by RT/PCR of total cellular RNA, but this approach does not work well for null mutations since the defective transcript does not accumulate in the cytoplasm. We have altered our RNA extraction method to separate RNA from the nuclear and cytoplasmic compartments of cultured fibroblasts. Standard methods of mutation identification (RT/PCR followed by SSCP) is applied to each RNA fraction. DNA from an abnormal band on the SSCP gel is eluted and amplified by PCR for cloning and sequencing. Using this approach we have identified an Asp to Asn change in exon 50 (type II OI) and a Gly to Arg in exon 11 (type I OI) of the COL1A1 gene. These changes were found in both nuclear and cytoplasmic compartments. These putative mutations are currently being confirmed by protein studies. In contrast, three patients with mild OI associated with reduced {proportional_to}(I)mRNA, had distinguishing SSCP bands present in the nuclear but not the cytoplasmic compartment. In one case a frame shift mutation was observed, while the other two revealed polymorphisms. The compartmentalization of the mutant allele has directed us to look elsewhere in the transcript for the causative mutation. This approach to mutation identification is capable of distinguishing these fundamentally different types of mutations and allows for preferential cloning and sequencing of the abnormal allele.

  9. Thermal regulation of tightly packed solid-state photodetectors in a 1 mm{sup 3} resolution clinical PET system

    SciTech Connect (OSTI)

    Freese, D. L.; Vandenbroucke, A.; Innes, D.; Lau, F. W. Y.; Hsu, D. F. C.; Reynolds, P. D.; Levin, Craig S.

    2015-01-15

    Purpose: Silicon photodetectors are of significant interest for use in positron emission tomography (PET) systems due to their compact size, insensitivity to magnetic fields, and high quantum efficiency. However, one of their main disadvantages is fluctuations in temperature cause strong shifts in gain of the devices. PET system designs with high photodetector density suffer both increased thermal density and constrained options for thermally regulating the devices. This paper proposes a method of thermally regulating densely packed silicon photodetectors in the context of a 1 mm{sup 3} resolution, high-sensitivity PET camera dedicated to breast imaging. Methods: The PET camera under construction consists of 2304 units, each containing two 8 × 8 arrays of 1 mm{sup 3} LYSO crystals coupled to two position sensitive avalanche photodiodes (PSAPD). A subsection of the proposed camera with 512 PSAPDs has been constructed. The proposed thermal regulation design uses water-cooled heat sinks, thermoelectric elements, and thermistors to measure and regulate the temperature of the PSAPDs in a novel manner. Active cooling elements, placed at the edge of the detector stack due to limited access, are controlled based on collective leakage current and temperature measurements in order to keep all the PSAPDs at a consistent temperature. This thermal regulation design is characterized for the temperature profile across the camera and for the time required for cooling changes to propagate across the camera. These properties guide the implementation of a software-based, cascaded proportional-integral-derivative control loop that controls the current through the Peltier elements by monitoring thermistor temperature and leakage current. The stability of leakage current, temperature within the system using this control loop is tested over a period of 14 h. The energy resolution is then measured over a period of 8.66 h. Finally, the consistency of PSAPD gain between independent

  10. Data:00cdded9-47a1-49b6-a217-10941ffbefc6 | Open Energy Information

    Open Energy Info (EERE)

    cdded9-47a1-49b6-a217-10941ffbefc6 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading......

  11. Data:F9109623-5e77-4c82-a1f5-019fc4f4d029 | Open Energy Information

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    Open Energy Info (EERE)

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  15. Microsoft Word - Sibener Final Technical Report for DOE Submitted...

    Office of Scientific and Technical Information (OSTI)

    ... activated chemisorption on single crystal surfaces - at this time one cannot ... We have succeeded in growing relatively high quality graphene on Rh(111) using ethylene in ...

  16. How to Submit Forms: Exclusionary List: For the PC Electronic...

    U.S. Energy Information Administration (EIA) Indexed Site

    See PART 3 of the instructions. 2 4 Permanently ceased operation. See PART 3 of the ... Comments: (To separate one comment from another, press ALT+ENTER) In operation Temporarily ...

  17. Instructions for Submitting Document to OpenNet | Department...

    Energy Savers [EERE]

    an OpenNet Logon Name and Password. If you don't already have one, go to the OpenNet web site at: http:www.osti.govopennet. Click on the LOGIN link on the top right. Read...

  18. How to Submit a 2014 ERCAP (allocations) Request

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to Make a Battery in 7 Steps How to Make a Battery in 7 Steps May 24, 2016 - 11:30am Addthis See how batteries are assembled at PNNL's Advanced Battery Facility. | Video by PNNL. Franny White Pacific Northwest National Laboratory From smartphones to electric cars and even the Tesla Powerwall, rechargeable batteries power our modern lives. But have you ever stopped to wonder what's inside these devices that allow us to send emojis, drive around town and so much more? If so, check out the Advanced

  19. REMS Program Policy for submitting of Personally Identifiable...

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    Concerns: Total collective dose for the project *Pre-job collective dose estimate: person-mrem *Actual collective dose measured: person-mrem Effect on dose rates, airborne and...

  1. When to submit a certification application | Department of Energy

    Energy Savers [EERE]

    What's Your PEV Readiness Score? What's Your PEV Readiness Score? February 14, 2013 - 10:30am Addthis PEV readiness is a community-wide effort that requires charging infrastructure, planning, regulations and support services. The new PEV Scorecard helps communities determine their PEV friendliness. | Photo courtesy of IKEA Orlando. PEV readiness is a community-wide effort that requires charging infrastructure, planning, regulations and support services. The new PEV Scorecard helps communities

  2. Submit a Buy American Complaint | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Resources Section 1605 of the American Recovery and Reinvestment Act of 2009 sets forth the Buy American requirements for recipients of Recovery Act financial assistance,...

  3. Organization Name Date Submitted File Name ACEEE Steve Nadel

    Broader source: Energy.gov (indexed) [DOE]

    Association of Public and Land Grant Universities Jim Turner 4152011 Association of Public and Land Grant Universities 4.15.2011 Babcock & Wilcox Company Kip Alexander 4152011 ...

  4. Instructions for Submitting Documents to OpenNet

    Energy Savers [EERE]

    If you don't already have one, go to the OpenNet web site at: http:www.osti.govopennet. ... and document images: through a 475.1 web form which gets information for one ...

  5. How do I submit challenge materials? | OpenEI Community

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    Groups Menu You must login in order to post into this group. Recent content Travis Brown and Kamran Baksh, Final Submission For various reasons, you may w... How can I view...

  6. How can I view submitted materials? | OpenEI Community

    Open Energy Info (EERE)

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  7. AARP submits the following comments on consumers and smart grid...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... How should insights about consumer decision-making be incorporated into federal-state collaborative efforts such as the FERC National Action Plan on Demand Response? Consumer ...

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    National Nuclear Security Administration (NNSA)

    was added to M&O contracts as a savings tool made available by the NNSA-wide Business Management Advisory Council, chartered specifically to implement enterprise-level...

  9. Truck fire Corrective Action Plan submitted to Carlsbad Field...

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    fire Accident Investigation Board report. On February 5, an underground mine fire involving a salt haul truck occurred in WIPP's underground mine. The DOE-appointed Accident ...

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    Typical Grid computing scenarios involve many distributed hardware and software components. The more components that are involved, the more likely it is that one of them may fail. In order for Grid computing to succeed, there must be a simple mechanism to determine which component failed and why. Instrumentation of all Grid applications and middleware is an important part of the solution to this problem. However, it must be possible to control and adapt the amount of instrumentation data

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    an ERCAP Request Clayton B agwell NERSC A ccount S upport --- 1 --- September 6 , 2 012 ERCAP --- 2 --- "Energy R esearch Compu;ng A lloca;ons Process" h=p://www.nersc.gov/users/ accounts/alloca;ons/deadlines --- 3 --- ERCAP A pplica;on D eadlines --- 4 --- h=ps://www.nersc.gov/users/ accounts/alloca;ons/overview/ --- 5 --- Who c an a pply? A nyone w ho's work s upports t he D OE O ffice o f Science M issions --- 6 --- h=p://www.nersc.gov/users/accounts/ alloca;ons/first---alloca;on

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  1. Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis

    SciTech Connect (OSTI)

    Buchko, Garry W.; Robinson, Howard; Abendroth, Jan; Clitfon, Mathew C.; Zhang, Yanfeng; Hewitt, Stephen N.; Staker, Bart L.; Van Voorhis, Wesley C.; Mylera, Peter J.

    2015-05-01

    Cryptosporidiosis is an infectious disease caused by protozoan parasites from the Cryptosporidium species. Infection is associated with mild to severe diarrhea that usually resolves spontaneously in healthy human adults, but may lead to severe complications in young children and in immunocompromised patients. The genome of Cryptosporidium parvum contains a gene, CUTA_CRYPI, that may play a role in regulating the intracellular concentration of copper, a toxic element if left unchecked. Here we report the crystal structure for this CutA1 protein, Cp-CutA1, is reported at 2.0 resolution (4E98). As observed for other CutA1 structures, the 117-residue protein is a trimer with a core ferrodoxin-like fold. Circular dichroism spectroscopy shows little unfolding of Cp-CutA1 up to 353 K. This robustness is corroborated by H-?N HSQC spectra at 333 K that is characteristic of a folded protein, suggesting NMR spectroscopy may be a useful tool to further probe the function of the CutA1 proteins. While robust, Cp-CutA1 is not as stable as the homologous protein from a hyperthermophile, perhaps due to a wide ?-bulgein ?2 that protrudes P48 and S49 outside the ?-sheet.

  2. Caffeic acid phenethyl ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible factor-1α

    SciTech Connect (OSTI)

    Kim, Hyung Gyun; Han, Eun Hee; Im, Ji Hye; Lee, Eun Ji; Jin, Sun Woo; Jeong, Hye Gwang

    2015-09-25

    Caffeic acid phenethyl ester (CAPE), a natural component of propolis, is reported to have anticarcinogenic properties, although its precise chemopreventive mechanism remains unclear. In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. CAPE reduced the formation of the benzo[a]pyrene-DNA adduct. Moreover, CAPE inhibited 3-MC-induced CYP1A1 activity, mRNA expression, protein level, and promoter activity. CAPE treatment also decreased 3-MC-inducible xenobiotic-response element (XRE)-linked luciferase, aryl hydrocarbons receptor (AhR) transactivation and nuclear localization. CAPE induced hypoxia inducible factor-1α (HIF-1α) protein level and HIF-1α responsible element (HRE) transcriptional activity. CAPE-mediated HIF-1α reduced 3-MC-inducible CYP1A1 protein expression. Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR and HIF-1α induction. - Highlights: • CAPE reduced the formation of the benzo[a]pyrene-DNA adduct. • CAPE inhibited 3-MC-induced CYP1A1 expression. • CAPE induced HIF-1α induction. • CAPE-mediated HIF-1α reduced 3-MC-inducible CYP1A1 expression.

  3. The R6A-1 peptide binds to switch II of G{alpha}{sub i1} but is not a GDP-dissociation inhibitor

    SciTech Connect (OSTI)

    Willard, Francis S. . E-mail: fwillard@med.unc.edu; Siderovski, David P.

    2006-01-27

    Heterotrimeric G-proteins are molecular switches that convert signals from membrane receptors into changes in intracellular physiology. Recently, several peptides that bind heterotrimeric G-protein {alpha} subunits have been isolated including the novel G{alpha}{sub i1} . GDP binding peptides R6A and KB-752. The R6A peptide and its minimized derivative R6A-1 interact with G{alpha}{sub i1} . GDP. Based on spectroscopic analysis of BODIPYFL-GTP{gamma}S binding to G{alpha}{sub i1}, it has been reported that R6A-1 has guanine nucleotide dissociation inhibitor (GDI) activity against G{alpha}{sub i1} [W.W. Ja, R.W. Roberts, Biochemistry 43 (28) (2004) 9265-9275]. Using radioligand binding, we show that R6A-1 is not a GDI for G{alpha}{sub i1} subunits. Furthermore, we demonstrate that R6A-1 reduces the fluorescence quantum yield of the G{alpha}{sub i1}-BODIPYFL-GTP{gamma}S complex, thus explaining the previously reported GDI activity as a fluorescence artifact. We further show that R6A-1 has significant sequence similarity to the guanine nucleotide exchange factor peptide KB-752 that binds to switch II of G{alpha}{sub i1}. We use competitive binding analysis to show that R6A-1 also binds to switch II of G{alpha} subunits.

  4. Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Buchko, Garry W.; Robinson, Howard; Abendroth, Jan; Clitfon, Mathew C.; Zhang, Yanfeng; Hewitt, Stephen N.; Staker, Bart L.; Van Voorhis, Wesley C.; Mylera, Peter J.

    2015-05-01

    Cryptosporidiosis is an infectious disease caused by protozoan parasites from the Cryptosporidium species. Infection is associated with mild to severe diarrhea that usually resolves spontaneously in healthy human adults, but may lead to severe complications in young children and in immunocompromised patients. The genome of Cryptosporidium parvum contains a gene, CUTA_CRYPI, that may play a role in regulating the intracellular concentration of copper, a toxic element if left unchecked. Here we report the crystal structure for this CutA1 protein, Cp-CutA1, is reported at 2.0 Å resolution (4E98). As observed for other CutA1 structures, the 117-residue protein is a trimer withmore » a core ferrodoxin-like fold. Circular dichroism spectroscopy shows little unfolding of Cp-CutA1 up to 353 K. This robustness is corroborated by ¹H-¹⁵N HSQC spectra at 333 K that is characteristic of a folded protein, suggesting NMR spectroscopy may be a useful tool to further probe the function of the CutA1 proteins. While robust, Cp-CutA1 is not as stable as the homologous protein from a hyperthermophile, perhaps due to a wide β-bulgein β2 that protrudes P48 and S49 outside the β-sheet.« less

  5. Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression

    SciTech Connect (OSTI)

    Do, Minh Truong; Kim, Hyung Gyun; Tran, Thi Thu Phuong; Khanal, Tilak; Choi, Jae Ho; Chung, Young Chul; Jeong, Tae Cheon; Jeong, Hye Gwang

    2014-10-01

    Induction of cytochrome P450 (CYP) 1A1 and CYP1B1 by environmental xenobiotic chemicals or endogenous ligands through the activation of the aryl hydrocarbon receptor (AhR) has been implicated in a variety of cellular processes related to cancer, such as transformation and tumorigenesis. Here, we investigated the effects of the anti-diabetes drug metformin on expression of CYP1A1 and CYP1B1 in breast cancer cells under constitutive and inducible conditions. Our results indicated that metformin down-regulated the expression of CYP1A1 and CYP1B1 in breast cancer cells under constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced conditions. Down-regulation of AhR expression was required for metformin-mediated decreases in CYP1A1 and CYP1B1 expression, and the metformin-mediated CYP1A1 and CYP1B1 reduction is irrelevant to estrogen receptor α (ERα) signaling. Furthermore, we found that metformin markedly down-regulated Sp1 protein levels in breast cancer cells. The use of genetic and pharmacological tools revealed that metformin-mediated down-regulation of AhR expression was mediated through the reduction of Sp1 protein. Metformin inhibited endogenous AhR ligand-induced CYP1A1 and CYP1B1 expression by suppressing tryptophan-2,3-dioxygenase (TDO) expression in MCF-7 cells. Finally, metformin inhibits TDO expression through a down-regulation of Sp1 and glucocorticoid receptor (GR) protein levels. Our findings demonstrate that metformin reduces CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating AhR signaling. Metformin would be able to act as a potential chemopreventive agent against CYP1A1 and CYP1B1-mediated carcinogenesis and development of cancer. - Graphical abstract: Schematic of the CYP1A1 and CYP1B1 gene regulation by metformin. - Highlights: • Metformin inhibits CYP1A1 and CYP1B1 expression. • Metformin down-regulates the AhR signaling. • Metformin reduces Sp1 protein expression. • Metformin suppresses TDO expression.

  6. Search for a light Higgs resonance in radiative decays of the Y(1S) with a charm tag

    SciTech Connect (OSTI)

    Lees, J. P.

    2015-04-10

    In this study, a search is presented for the decay Υ(1S)→γA0, A0 → cc¯, where A0 is a candidate for the CP-odd Higgs boson of the next-to-minimal supersymmetric standard model. The search is based on data collected with the BABAR detector at the Υ(2S) resonance. A sample of Υ(1S) mesons is selected via the decay Υ(2S) → π+π Υ(1S). The A0 → cc¯ decay is identified through the reconstruction of hadronic D0, D+, and D*(2010)+ meson decays. No significant signal is observed. The measured 90% confidence-level upper limits on the product branching fraction B(Υ(1S) → γA0)×B(A0 → cc¯) range from 7.4×10–5 to 2.4×10–3 for A0 masses from 4.00 to 8.95 GeV/c2 and 9.10 to 9.25 GeV/c2, where the region between 8.95 and 9.10 GeV/c2 is excluded because of background from Υ(2S) → γχbJ(1P), χbJ(1P) → γΥ(1S) decays.

  7. Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro

    SciTech Connect (OSTI)

    Yang, Fangxing; Zhuang, Shulin; Zhang, Chao; Dai, Heping; Liu, Weiping

    2013-06-15

    Increasing environmental pollution by carcinogens such as some of persistent organic pollutants (POPs) has prompted growing interest in searching for chemopreventive compounds which are readily obtainable. Sulforaphane (SFN) is isolated from cruciferous vegetables and has the potentials to reduce carcinogenesis through various pathways. In this study, we studied the effects of SFN on CYP1A1 activity and genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, probably through binding to aryl hydrocarbon receptor and/or CYP1A1 revealed by molecular docking. However, SFN promoted TCDD-induced DNA damage in yeast cells and reduced the viability of initiated yeast cells. Besides, it is surprising that SFN also failed to reduce genotoxicity induced by other genotoxic reagents which possess different mechanisms to lead to DNA damage. Currently, it is difficult to predict whether SFN has the potentials to reduce the risk of TCDD based on the conflicting observations in the study. Therefore, further studies should be urgent to reveal the function and mechanism of SFN in the stress of such POPs on human health. - Highlights: Sulforaphane inhibited TCDD-induced CYP1A1 activity in H4IIE cells. Sulforaphane may bind to aryl hydrocarbon receptor and/or CYP1A1. Sulforaphane promoted TCDD-induced DNA damage in yeast cells. Sulforaphane may promote DNA damage by DNA strand breaks or DNA alkylation.

  8. Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles

    SciTech Connect (OSTI)

    Peretz, Jackye; Flaws, Jodi A.

    2013-09-01

    Bisphenol A (BPA) is the backbone of polycarbonate plastic products and the epoxy resin lining of aluminum cans. Previous studies have shown that exposure to BPA decreases sex steroid hormone production in mouse antral follicles. The current study tests the hypothesis that BPA first decreases the expression levels of the steroidogenic enzyme cytochrome P450 side-chain cleavage (Cyp11a1) and steroidogenic acute regulatory protein (StAR) in mouse antral follicles, leading to a decrease in sex steroid hormone production in vitro. Further, the current study tests the hypothesis that these effects are acute and reversible after removal of BPA. Exposure to BPA (10 μg/mL and 100 μg/mL) significantly decreased expression of Cyp11a1 and StAR beginning at 18 h and 72 h, respectively, compared to controls. Exposure to BPA (10 μg/mL and 100 μg/mL) significantly decreased progesterone levels beginning at 24 h and decreased androstenedione, testosterone, and estradiol levels at 72 h and 96 h compared to controls. Further, after removing BPA from the culture media at 20 h, expression of Cyp11a1 and progesterone levels were restored to control levels by 48 h and 72 h, respectively. Additionally, expression of StAR and levels of androstenedione, testosterone, and estradiol never decreased compared to controls. These data suggest that BPA acutely decreases expression of Cyp11a1 as early as 18 h and this reduction in Cyp11a1 may lead to a decrease in progesterone production by 24 h, followed by a decrease in androstenedione, testosterone, and estradiol production and expression of StAR at 72 h. Therefore, BPA exposure likely targets Cyp11a1 and steroidogenesis, but these effects are reversible with removal of BPA exposure. - Highlights: • BPA may target Cyp11a1 to inhibit steroidogenesis in antral follicles. • BPA may decrease the expression of Cyp11a1 prior to inhibiting steroidogenesis. • The adverse effects of BPA on steroidogenesis in antral follicles are reversible.

  9. Linkage mapping of the gene for Type III collagen (COL3A1) to human chromosome 2q using a VNTR polymorphism

    SciTech Connect (OSTI)

    Tiller, G.E.; Polumbo, P.A.; Summar, M.L. )

    1994-03-15

    The gene for the [alpha]1(III) chain of type III collagen, COL3A1, has been previously mapped to human chromosome 2q24.3-q31 by in situ hybridization. Physical mapping by pulsed-field gel electrophoresis has demonstrated that COL3A1 lies within 35 kb of COL5A2. The authors genotyped the CEPH families at the COL3A2 locus using a pentanucleotide repeat polymorphism within intron 25. They demonstrated significant linkage to 18 anonymous markers as well as the gene for carbamyl phosphate synthetase (CPSI), which had been previously mapped to this region. No recombination was seen between COL3A1 and COL5A2 (Z = 9.93 at [theta] = 0) or D2S24 (Z = 10.55 at [theta] = 0). The locus order is (D2S32-D2S138-D2S148)-(D2S24-COL5A2-COL3A1)-(D2S118-D2S161), with odds of 1:2300 for the next most likely order. These relationships are consistent with the physical mapping of COL3A1 to the distal portion of 2q and place it proximal to CPSI by means of multipoint analysis. These linkage relationships should prove useful in further studies of Ehlers-Danlos syndrome type IV and carbamyl phosphate synthetase I deficiency and provide an additional framework for localizing other genes in this region. 13 refs., 2 figs., 1 tab.

  10. bnw32a1.tmp

    Office of Scientific and Technical Information (OSTI)

    Raw materials are shipped in by truck. or rail. A detailed analysis of the economic estimates for the baseline process is given in Appendix 4. The total capital investment for...

  11. bnw32a1.tmp

    Office of Scientific and Technical Information (OSTI)

    herein do not necessarily state or reflect those of the ... 5.2 Preparation and Testing of Polymer ... evaporator to a damp solid, which was mixed with ...

  12. uth93a1.tmp

    National Nuclear Security Administration (NNSA)

    ... Worman, F. C. V., 1969. Archeological inveigations at the U.S. Atomic Energy Commission's ... Emory's bacchari; Iittleleafmountain mahogany rabbitbrush green rabbitbmsh blackbrush ...

  13. Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample

    SciTech Connect (OSTI)

    Lind, Lars; Penell, Johanna; Syvänen, Anne-Christine; Axelsson, Tomas; Ingelsson, Erik; Morris, Andrew P.; Lindgren, Cecilia; Salihovic, Samira; Bavel, Bert van; Lind, P. Monica

    2014-08-15

    Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. We evaluated if circulating levels of PCBs in a population sample were related to genetic variation in the genes encoding these CYPs. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), 21 SNPs in the CYP1A1, CYP1A2 and CYP1B1 genes were genotyped. Sixteen PCB congeners were analysed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS). Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). However, there were several additional SNPs in the CYP1A2 and CYP1B1 that showed nominally significant associations with PCB118 levels (p-values in the 0.003–0.05 range). Further, several SNPs in the CYP1B1 gene were related to both PCB156 and PCB206 with p-values in the 0.005–0.05 range. Very few associations with p<0.05 were seen for PCB126, PCB169 or PCB170. Genetic variation in the CYP1A1 was related to circulating PCB118 levels in the general elderly population. Genetic variation in CYP1A2 and CYP1B1 might also be associated with other PCBs. - Highlights: • We studied the relationship between PCBs and the genetic variation in the CYP genes. • Cross sectional data from a cohort of elderly were analysed. • The PCB levels were evaluated versus 21 SNPs in three CYP genes. • PCB 118 was related to variation in the CYP1A1 gene.

  14. Draft Genome Sequence of thermoalkaliphilic Caldalkalibacillus thermarum strain TA2.A1 Reveals Molecular Adaptations to Extreme pH and Temperature

    SciTech Connect (OSTI)

    Kalamorz, Falk; Keis, Stefanie; Stanton, Jo-Ann; Brown, Steven D; Klingeman, Dawn Marie; Land, Miriam L; Han, Cliff; Martin, S L.; Morgan, Hugh; Cook, Greg

    2011-01-01

    The genes and molecular machines that allow for a thermoalkaliphilic lifestyle have not been defined. To address this goal, we report on the improved high-quality draft genome sequence of Caldalkalibacillus thermarum strain TA2.A1, an obligately aerobic bacterium that grows optimally at pH 9.5 and 65 to 70 C on a wide variety of carbon and energy sources.

  15. Premature chain termination is a unifying mechanism for COL1A1 null alleles in osteogenesis imperfecta type I cell strains

    SciTech Connect (OSTI)

    Willing, M.C.; Deschenes, S.P.; Roberts, E.J.

    1996-10-01

    Nonsense and frameshift mutations, which predict premature termination of translation, often cause a dramatic reduction in the amount of transcript from the mutant allele (nonsense-mediated mRNA decay). In some genes, these mutations also influence RNA splicing and induce skipping of the exon that contains the nonsense codon. To begin to dissect how premature termination alters the metabolism of RNA from the COL1A1 gene, we studied nonsense and frameshift mutations distributed over exons 11-49 of the gene. These mutations were originally identified in 10 unrelated families with osteogenesis imperfecta (OI) type I. We observed marked reduction in steady-state amounts of mRNA from the mutant allele in both total cellular and nuclear RNA extracts of cells from affected individuals, suggesting that nonsense-mediated decay of COL1A1 RNA is a nuclear phenomenon. Position of the mutation within the gene did not influence this observation. None of the mutations induced skipping of either the exon containing the mutation or, for the frameshifts, the downstream exons with the new termination sites. Our data suggest that nonsense and frameshift mutations throughout most of the COL1A1 gene result in a null allele, which is associated with the predictable mild clinical phenotype, OI type I. 42 refs., 6 figs., 1 tab.

  16. A second mutation in the type II procollagen gene (COL2A1) causing Stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon

    SciTech Connect (OSTI)

    Ahmad, N.N.; Knowlton, R.G.; DiMascio, J.; Prockop, D.J. ); McDonald-McGinn, D.M.; Zackai, E.H.; LaRossa, D. )

    1993-01-01

    Genetic linkage analyses suggest that mutations in type II collagen may be responsible for Stickler syndrome, or arthro-ophthalmopathy (AO), in many families. In the present study oligonucleotide primers were developed to amplify and directly sequence eight of the first nine exons of the gene for type II procollagen (COL2A1). Analysis of the eight exons in 10 unrelated probands with AO revealed that one had a single-base mutation in one allele that changed the codon of -CGA- for arginine at amino acid position [alpha]1-9 in exon 7 to a premature termination signal for translation. The second mutation found to cause AO was, therefore, similar to the first in that both created premature termination signals in the COL2A1 gene. Since mutations producing premature termination signals have not previously been detected in genes for fibrillar collagens, the results raise the possibility that such mutations in the COL2A1 gene are a common cause of AO. 33 refs., 4 figs., 2 tabs.

  17. Assessment of Hard-to-Detect Radionuclide Levels in Decommissioning Waste From the Bohunice NPP-A1, Slovakia, for Clearance and Disposal Purposes

    SciTech Connect (OSTI)

    Slavik, O.; Moravek, J.; Stubna, M.

    2002-02-26

    For assessments of hard-to-detect radionuclides (HD-RN) contents in various type of radwastes at the NPP-A1, available empirical data referenced to 137Cs (actinides, 90Sr, 99Tc, 63Ni, 14C) and the theoretical assessment for the remaining HD-RN using calculated RN inventory and a simple model with effective relative (137Cs) spent fuel release fractions was applied. The analytical data of extended radiochemical analysis for the existing available operational radwaste forms have been reviewed for this purpose. 137Cs, 90Sr and 241Am were set up as release markers for partial spent fuel release groups of HD-RNs within which the total fractions of HD-RN released to the operational radwastes were assumed to be constant. It was shown by the assessment carried out that 137Cs and HD-RNs 129I, 99Tc, and partly 79Se and 14C are the main contributors to the disposal dose limit for the radioactive concentrate at NPP A-1. In the case of the radioactive sludge from the operational radwaste system the role of predominant dose contributors belongs to actinides 239,240Pu and 241Am. In the case of clearance of radioactive material from the NPP-A1 site, only the reference radionuclide, 137Cs was predicted to be the most dominant dose contributor. In all of these cases the estimated contributions of other hard-to-detect radionuclides to respective disposal or release dose limit are lower by 2 and more orders of magnitude. As a lesson learned, the most attention is proposed to focus on the control and measurement of the critical HD-RNs indicated by the assessment. For the control of less important HD-RNs, the developed release coefficient method is sufficient to be applied.

  18. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines

    SciTech Connect (OSTI)

    Vorrink, Sabine U.; Severson, Paul L.; Kulak, Mikhail V.; Futscher, Bernard W.; Domann, Frederick E.

    2014-02-01

    The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs). Activation of AhR responsive genes requires AhR dimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT), a heterodimeric partner also shared by the hypoxia-inducible factor-1α (HIF-1α) protein. TCDD-stimulated AhR transcriptional activity can be influenced by hypoxia; however, it less well known whether hypoxia interferes with AhR transcriptional transactivation in the context of PCB-mediated AhR activation in human cells. Elucidation of this interaction is important in liver hepatocytes which extensively metabolize ingested PCBs and experience varying degrees of oxygen tension during normal physiologic function. This study was designed to assess the effect of hypoxia on AhR transcriptional responses after exposure to 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126). Exposure to 1% O{sub 2} prior to PCB 126 treatment significantly inhibited CYP1A1 mRNA and protein expression in human HepG2 and HaCaT cells. CYP1A1 transcriptional activation was significantly decreased upon PCB 126 stimulation under conditions of hypoxia. Additionally, hypoxia pre-treatment reduced PCB 126 induced AhR binding to CYP1 target gene promoters. Importantly, ARNT overexpression rescued cells from the inhibitory effect of hypoxia on XRE-luciferase reporter activity. Therefore, the mechanism of interference of the signaling crosstalk between the AhR and hypoxia pathways appears to be at least in part dependent on ARNT availability. Our results show that AhR activation and CYP1A1 expression induced by PCB 126 were significantly inhibited by hypoxia and hypoxia might therefore play an important role in PCB metabolism and toxicity. - Highlights: • Significant crosstalk exists between AhR and HIF-1α signaling. • Hypoxia perturbs PCB 126 induced AhR function and

  19. Test and demonstration of a 1-MW wellhead generator: helical screw expander power plant, Model 76-1. Final report to the International Energy Agency

    SciTech Connect (OSTI)

    Not Available

    1985-07-04

    A 1-MW geothermal wellhead power plant incorporating a Lysholm or helical screw expander (HSE) was field tested between 1980 and 1983 by Mexico, Italy, and New Zealand with technical assistance from the United States. The objectives were to provide data on the reliability and performance of the HSE and to assess the costs and benefits of its use. The range of conditions under which the HSE was tested included loads up to 933 kW, mass flowrates of 14,600 to 395, 000 lbs/hr, inlet pressures of 64 to 220 psia, inlet qualities of 0 to 100%, exhaust pressures of 3.1 to 40 psia, total dissolved solids up to 310,000 ppM, and noncondensible gases up to 38% of the vapor mass flow. Typical machine efficiencies of 40 to 50% were calculated. For most operations efficiency increased approximately logarithmically with shaft power, while inlet quality and rotor speed had only small effects. The HSE was designed with oversized internal clearances in the expectation that adherent scale would form during operation. Improvements in machine efficiency of 3.5 to 4 percentage points were observed over some test periods with some scale deposition. A comparison with a 1-MW back-pressure turbine showed that the HSE can compete favorably under certain conditions. The HSE was found to be a rugged energy conversion machine for geothermal applications, but some subsystems were found to require further development. 7 refs., 28 figs., 5 tabs.

  20. Location of the spinal cerebellar ataxia 2 locus to a 1 cM interval on chromsome 12q23-24.1

    SciTech Connect (OSTI)

    Allotey, R.; Twells, R.; Orozco, G.

    1994-09-01

    Spinocerebellar ataxia 2 (SCA2) is a dominantly inherited neurodegenerative disorder characterised by progressive ataxia, dysarthria, dysmetria and dysdiadochokinesia. We have previously assigned the disease locus to chromosome 12q23-24.1 in a population from the Holguin province, Cuba, within a 31 cM interval flanked by the anonymous marker D12S53 and the phospholipase A2 gene (PLA2). Clinical as much as genealogical and geographical evidence indicate that the Cuban pedigrees are homogeneous and descend from a common ancestor. We now report fine genetic mapping of the disease locus with fourteen microsatellite loci known to span this region, which positions SCA2 in a 1 cM interval defined by the loci D12S84-AFM291xe9. Observation of a common haplotype segregating with the disease supports the existence of a founder effect in the Holguin pedigrees.

  1. Synthesis, selected coordination chemistry and extraction behavior of a (phosphinoylmethyl)pyridyl N-oxide-functionalized ligand based upon a 1,4-diazepane platform

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ouizem, Sabrina; Rosario Amorin, Daniel; Dickie, Diane A.; Cramer, Roger E.; Campana, Charles F.; Hay, Benjamin P.; Podair, Julien; Delmau, Laetitia H.; Paine, Robert T.

    2015-05-09

    For syntheses of new multidentate chelating ligands ((6,6'4(1,4-diazepane-1,4-diyl)bis(methylene))bis(pyridine-6,2-diyl))bis(methylene))bis(diphenylphosphine oxide) (2) and 6,6'-((1,4-diazepane1,4-diyl)bis(methylene))bis(2-((diphenylphosphoryl)methyl)pyridine 1-oxide) (3), based upon a 1,4-diazepane platform functionalized with 2-(diphenylphosphinoylmethyl)pyridine P-oxide and 2-(diphenylphosphinoylmethyl)pyridine NP-dioxide fragments, respectively, the results are reported. Our results from studies of the coordination chemistry of the ligands with selected lanthanide nitrates and Cu(BF4)(2) are outlined, and crystal structures for two complexes, [Cu(2)](BF4)2 and [Cu(3)](BF4)2, are described along with survey Eu(III) and Am(III) solvent extraction analysis, for 3.

  2. Synthesis, selected coordination chemistry and extraction behavior of a (phosphinoylmethyl)pyridyl N-oxide-functionalized ligand based upon a 1,4-diazepane platform

    SciTech Connect (OSTI)

    Ouizem, Sabrina; Rosario Amorin, Daniel; Dickie, Diane A.; Cramer, Roger E.; Campana, Charles F.; Hay, Benjamin P.; Podair, Julien; Delmau, Laetitia H.; Paine, Robert T.

    2015-05-09

    For syntheses of new multidentate chelating ligands ((6,6'4(1,4-diazepane-1,4-diyl)bis(methylene))bis(pyridine-6,2-diyl))bis(methylene))bis(diphenylphosphine oxide) (2) and 6,6'-((1,4-diazepane1,4-diyl)bis(methylene))bis(2-((diphenylphosphoryl)methyl)pyridine 1-oxide) (3), based upon a 1,4-diazepane platform functionalized with 2-(diphenylphosphinoylmethyl)pyridine P-oxide and 2-(diphenylphosphinoylmethyl)pyridine NP-dioxide fragments, respectively, the results are reported. Our results from studies of the coordination chemistry of the ligands with selected lanthanide nitrates and Cu(BF4)(2) are outlined, and crystal structures for two complexes, [Cu(2)](BF4)2 and [Cu(3)](BF4)2, are described along with survey Eu(III) and Am(III) solvent extraction analysis, for 3.

  3. Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1

    SciTech Connect (OSTI)

    Katsuki, Yuko; Sakamoto, Kei; Minamizato, Tokutaro; Makino, Hatsune; Umezawa, Akihiro; Ikeda, Masa-aki; Perbal, Bernard; Amagasa, Teruo; Yamaguchi, Akira; Katsube, Ken-ichi

    2008-04-11

    CCN3/NOV activates the Notch signal through the carboxyl terminal cysteine-rich (CT) domain. CCN3 transfection to Kusa-A1 inhibited osteogenic differentiation and cell proliferation, which is accompanied by upregulation of Hes/Hey, Notch downstream targets, and p21, a CDK inhibitor. Upregulation of Hes/Hey and p21 was abrogated by the deletion of CT domain. Anti-proliferative activity of CCN3 was also abrogated by CT domain deletion whereas anti-osteogenic activity was not completely abrogated. We found that CT domain-deleted CCN3 still possesses antagonistic effect on BMP-2. These results suggest that CCN3 employs Notch and BMP pathways in anti-osteogenic activity while it inhibits cell proliferation uniquely by Notch/p21 pathway.

  4. Biophysical Analysis of Anopheles gambiae Leucine-Rich Repeat Proteins APL1A1, APL1B and APL1C and Their Interaction with LRIM1

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Williams, Marni; Summers, Brady J.; Baxter, Richard H. G.; Kobe, Bostjan

    2015-03-16

    Natural infection of Anopheles gambiae by malaria-causing Plasmodium parasites is significantly influenced by the APL1 genetic locus. The locus contains three closely related leucine-rich repeat (LRR) genes, APL1A, APL1B and APL1C. Multiple studies have reported the participation of APL1A—C in the immune response of A. gambiae to invasion by both rodent and human Plasmodium isolates. APL1C forms a heterodimer with the related LRR protein LRIM1 via a C-terminal coiled-coil domain that is also present in APL1A and APL1B. The LRIM1/APL1C heterodimer protects A. gambiae from infection by binding the complement-like protein TEP1 to form a stable and active immune complex.more » We report solution x-ray scatting data for the LRIM1/APL1C heterodimer, the oligomeric state of LRIM1/APL1 LRR domains in solution and the crystal structure of the APL1B LRR domain. The LRIM1/APL1C heterodimeric complex has a flexible and extended structure in solution. In contrast to the APL1A, APL1C and LRIM1 LRR domains, the APL1B LRR domain is a homodimer. The crystal structure of APL1B-LRR shows that the homodimer is formed by an N-terminal helix that complements for the absence of an N-terminal capping motif in APL1B, which is a unique distinction within the LRIM1/APL1 protein family. Full-length APL1A1 and APL1B form a stable complex with LRIM1. Our results support a model in which APL1A1, APL1B and APL1C can all form an extended, flexible heterodimer with LRIM1, providing a repertoire of functional innate immune complexes to protect A. gambiae from a diverse array of pathogens.« less

  5. Light hadron spectra in the constituent quark model with the Kobayashi-Kondo-Maskawa-'t Hooft effective U {sub A} (1) symmetry breaking interaction

    SciTech Connect (OSTI)

    Dmitrasinovic, V. . E-mail: dmitrasin@yahoo.com; Toki, H.

    2006-02-15

    We make a critical comparison of several versions of instanton-induced interactions present in the literature, all based on ITEP group's extension to three colours and flavours of 't Hooft's effective lagrangian, with the predictions of the phenomenological Kobayashi-Kondo-Maskawa (KKM) chiral quark lagrangian. We analyze the effects of all versions of the effective U {sub A} (1) symmetry breaking interactions on light hadron spectra in the non-relativistic constituent quark model. We show that the KKMT force, when used as a residual hyperfine interaction reproduces the correct ordering of pseudoscalar and vector mesons even without explicitly taking chiral symmetry into account. Moreover, the nucleon spectra are also correctly reproduced, only the Roper resonance remains too high, albeit lower than usual, at 1660 MeV. The latter's lower than expected mass is not due to a small excitation energy, as in the Glozman-Riska (GR) model, but to a combination of colour, flavour, and spatial wave function properties that enhance the relevant matrix elements. The KKMT interaction explicitly depends on flavour and spin of the quarks, but unlike the GR flavour-spin one it has a firm footing in QCD. In the process we provide several technical advances, in particular we show the first explicit derivation of the three-body Fierz transformation and apply it to the KKM interaction. We also discuss the ambiguities associated with the colour degree of freedom.

  6. An N-terminal glycine to cysteine mutation in the collagen COL1A1 gene produces moderately severe osteogenesis imperfecta

    SciTech Connect (OSTI)

    Wilcox, W.; Scott, L.; Cohn, D.

    1994-09-01

    Osteogenesis imperfecta (OI) is usually due to mutations in the type I procollagen genes COL1A1 and COL1A2. Point mutations close to the N-terminus are generally milder than those near the C-terminus of the molecule (the gradient hypothesis of collagen mutations). We describe a patient with moderately severe OI due to a mutation in the N-terminal portion of the triple helical domain of the {alpha}1(I) chain. Electrophoretic analysis of collagen isolated from fibroblast cultures suggested the abnormal presence of a cysteine in the N-terminal portion of the {alpha}1(I) chain. Five overlapping DNA fragments amplified from fibroblast RNA were screened for mutations using single strand conformational polymorphism (SSCP) and heteroduplex analyses. Direct DNA sequence analysis of the single positive fragment demonstrated a G to T transversion, corresponding to a glycine to cysteine substitution at position 226 of the triple helical domain of the {alpha}1(I) chain. The mutation was confirmed by restriction enzyme analysis of amplified genomic DNA. The mutation was not present in fibroblasts from either phenotypically normal parent. Combining this mutation with other reported mutations, glycine to cysteine substitutions at positions 205, 211, 223, and 226 produce a moderately severe phenotype whereas flanking mutations at positions 175 and 382 produce a mild phenotype. This data supports a regional rather than a gradient model of the relationship between the nature and location of type I collagen mutations and OI phenotype.

  7. THE DEVELOPMENT OF A 1990 GLOBAL INVENTORY FOR SO(X) AND NO(X) ON A 1(DEGREE) X 1(DEGREE) LATITUDE-LONGITUDE GRID.

    SciTech Connect (OSTI)

    VAN HEYST,B.J.

    1999-10-01

    Sulfur and nitrogen oxides emitted to the atmosphere have been linked to the acidification of water bodies and soils and perturbations in the earth's radiation balance. In order to model the global transport and transformation of SO{sub x} and NO{sub x}, detailed spatial and temporal emission inventories are required. Benkovitz et al. (1996) published the development of an inventory of 1985 global emissions of SO{sub x} and NO{sub x} from anthropogenic sources. The inventory was gridded to a 1{degree} x 1{degree} latitude-longitude grid and has served as input to several global modeling studies. There is now a need to provide modelers with an update of this inventory to a more recent year, with a split of the emissions into elevated and low level sources. This paper describes the development of a 1990 update of the SO{sub x} and NO{sub x} global inventories that also includes a breakdown of sources into 17 sector groups. The inventory development starts with a gridded global default EDGAR inventory (Olivier et al, 1996). In countries where more detailed national inventories are available, these are used to replace the emissions for those countries in the global default. The gridded emissions are distributed into two height levels (0-100m and >100m) based on the final plume heights that are estimated to be typical for the various sectors considered. The sources of data as well as some of the methodologies employed to compile and develop the 1990 global inventory for SO{sub x} and NO{sub x} are discussed. The results reported should be considered to be interim since the work is still in progress and additional data sets are expected to become available.

  8. A:\\1FRONT(REVISED).PDF

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... and traffic management, patents law, real and personal property management, ... Report (1995), and DOE's Contract Reform Team Report (1994) all have one thing in common. ...

  9. Microsoft Word - table_A1.doc

    U.S. Energy Information Administration (EIA) Indexed Site

    These differences may be due to quantities lost or to the effects of differences in company accounting systems in terms of scope and definition. A positive "unaccounted for" volume ...

  10. Diagnostics from a 1-D atmospheric column

    SciTech Connect (OSTI)

    Flatley, J.M.; Mace, G.

    1996-04-01

    Various diagnostics were computed from an array of radiosondes during an intensive field operation arranged by the Atmospheric Radiation Measurement Program. The network data was centered around the site at Lamont, Oklahoma. The apparent heat source and apparent moisture sink were computed and compared to the kinematic vertical velocity for both real data and the mesoscale analysis and prediction system. Three different case studies of various weathe regimes were examined.

  11. A1.5 Fusion Performance

    SciTech Connect (OSTI)

    Amendt, P

    2011-03-31

    Analysis and radiation hydrodynamics simulations for expected high-gain fusion target performance on a demonstration 1-GWe Laser Inertial Fusion Energy (LIFE) power plant in the mid-2030s timeframe are presented. The required laser energy driver is 2.2 MJ at a 0.351-{micro}m wavelength, and a fusion target gain greater than 60 at a repetition rate of 16 Hz is the design goal for economic and commercial attractiveness. A scaling-law analysis is developed to benchmark the design parameter space for hohlraum-driven central hot-spot ignition. A suite of integrated hohlraum simulations is presented to test the modeling assumptions and provide a basis for a near-term experimental resolution of the key physics uncertainties on the National Ignition Facility (NIF). The NIF is poised to demonstrate ignition by 2012 based on the central hot spot (CHS) mode of ignition and propagating thermonuclear burn [1]. This immediate prospect underscores the imperative and timeliness of advancing inertial fusion as a carbon-free, virtually limitless source of energy by the mid-21st century to substantially offset fossil fuel technologies. To this end, an intensive effort is underway to leverage success at the NIF and to provide the foundations for a prototype 'LIFE.1' engineering test facility by {approx}2025, followed by a commercially viable 'LIFE.2' demonstration power plant operating at 1 GWe by {approx}2035. The current design goal for LIFE.2 is to accommodate {approx}2.2 MJ of laser energy (entering the high-Z radiation enclosure or 'hohlraum') at a 0.351-{micro}m wavelength operating at a repetition rate of 16 Hz and to provide a fusion target yield of 132 MJ. To achieve this design goal first requires a '0-d' analytic gain model that allows convenient exploration of parameter space and target optimization. This step is then followed by 2- and 3-dimensional radiation-hydrodynamics simulations that incorporate laser beam transport, x-ray radiation transport, atomic physics, and thermonuclear burn [2]. These simulations form the basis for assessing the susceptibility to hydrodynamic instability growth, target performance margins, laser backscatter induced by plasma density fluctuations within the hohlraum, and the threat spectrum emerging from the igniting capsule, e.g., spectra, fluences and anisotropy of the x rays and ions, for input into the chamber survivability calculations. The simulations follow the guidelines of a 'point design' methodology, which formally designates a well-defined milestone in concept development that meets established criteria for experimental testing. In Section 2, the 0-d analytic gain model to survey gain versus laser energy parameter space is discussed. Section 3 looks at the status of integrated hohlraum simulations and the needed improvements in laser-hohlraum coupling efficiency to meet the LIFE.2 threshold (net) target gain of {approx}60. Section 4 considers advanced hohlraum designs to well exceed the LIFE.2 design goal for satisfactory performance margins. We summarize in Sec. 5.

  12. Residential Refrigerators-Freezers (Appendix A1)

    Broader source: Energy.gov [DOE]

    The Department of Energy (DOE) develops standardized data templates for reporting the results of tests conducted in accordance with current DOE test procedures. Templates may be used by third-party laboratories under contract with DOE that conduct testing in support of ENERGY STAR® verification, DOE rulemakings, and enforcement of the federal energy conservation standards.

  13. G to A substitution in 5{prime} donor splice site of introns 18 and 48 of COL1A1 gene of type I collagen results in different splicing alternatives in osteogenesis imperfecta type I cell strains

    SciTech Connect (OSTI)

    Willing, M.; Deschenes, S.

    1994-09-01

    We have identified a G to A substitution in the 5{prime} donor splice site of intron 18 of one COL1A1 allele in two unrelated families with osteogenesis imperfecta (OI) type I. A third OI type I family has a G to A substitution at the identical position in intron 48 of one COL1A1 allele. Both mutations abolish normal splicing and lead to reduced steady-state levels of mRNA from the mutant COL1A1 allele. The intron 18 mutation leads to both exon 18 skipping in the mRNA and to utilization of a single alternative splice site near the 3{prime} end of exon 18. The latter results in deletion of the last 8 nucleotides of exon 18 from the mRNA, a shift in the translational reading-frame, and the creation of a premature termination codon in exon 19. Of the potential alternative 5{prime} splice sites in exon 18 and intron 18, the one utilized has a surrounding nucleotide sequence which most closely resembles that of the natural splice site. Although a G to A mutation was detected at the identical position in intron 48 of one COL1A1 allele in another OI type I family, nine complex alternative splicing patterns were identified by sequence analysis of cDNA clones derived from fibroblast mRNA from this cell strain. All result in partial or complete skipping of exon 48, with in-frame deletions of portions of exons 47 and/or 49. The different patterns of RNA splicing were not explained by their sequence homology with naturally occuring 5{prime} splice sites, but rather by recombination between highly homologous exon sequences, suggesting that we may not have identified the major splicing alternative(s) in this cell strain. Both G to A mutations result in decreased production of type I collagen, the common biochemical correlate of OI type I.

  14. Microsoft Word - Final Scientific - Technical Report_DE-EE0005390_Cooper_Tire_Submitted

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Final Scientific/Technical Report Federal Agency: U.S. DOE/NETL Award No.: DE-EE0005390 Project Title: Demonstration of improved vehicle fuel efficiency through innovative tire design, materials, and weight reduction technologies PD/PI: Tim Donley, Lead Engineer Consortium/Teaming Members: NREL tmdonley@coopertire.com Phone: 419-429-7229 Submission Date: March 31, 2015 DUNS Number: 005037601 Recipient Organization: Cooper Tire & Rubber Company 701 Lima Ave. Findlay, OH 45840 Project/Grant

  15. This form may be submitted to the EIA by mail, fax, e-mail, or...

    U.S. Energy Information Administration (EIA) Indexed Site

    month." " since the last report, enter an ""X"" in the block:" " ",,,..."Mo",,,"Yea... "If this is a resubmission, enter an ""X"" in the block:",,,...

  16. This form may be submitted to the EIA by mail, fax, e-mail, or...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,,," Version No: 2014.001" "ANNUAL REPORT OF THE ORIGIN OF NATURAL GAS LIQUIDS PRODUCTION" "FORM EIA-64A" "REPORT YEAR 2014" "This report is...

  17. Sandia Research on PV Arc-Fault Detection Submitted for US Patent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Predictive Simulation of Engines Transportation Energy Consortiums Engine Combustion ... The 2011 National Electrical Code requires PV DC series arc-fault protection, but does ...

  18. M3FT-15OR0202212: SUBMIT SUMMARY REPORT ON THERMODYNAMIC EXPERIMENT AND MODELING

    SciTech Connect (OSTI)

    McMurray, Jake W.; Brese, Robert G.; Silva, Chinthaka M.; Besmann, Theodore M.

    2015-09-01

    Modeling the behavior of nuclear fuel with a physics-based approach uses thermodynamics for key inputs such as chemical potentials and thermal properties for phase transformation, microstructure evolution, and continuum transport simulations. Many of the lanthanide (Ln) elements and Y are high-yield fission products. The U-Y-O and U-Ln-O ternaries are therefore key subsystems of multi-component high-burnup fuel. These elements dissolve in the dominant urania fluorite phase affecting many of its properties. This work reports on an effort to assess the thermodynamics of the U-Pr-O and U-Y-O systems using the CALPHAD (CALculation of PHase Diagrams) method. The models developed within this framework are capable of being combined and extended to include additional actinides and fission products allowing calculation of the phase equilibria, thermochemical and material properties of multicomponent fuel with burnup.

  19. This form may be submitted to the EIA by mail, fax, e-mail, or...

    U.S. Energy Information Administration (EIA) Indexed Site

    under the Federal Energy Administration Act of 1974 (Public Law 93-275). Failure to comply may result in criminal fines, civil penalties and other sanctions as provided by law. ...

  20. This form may be submitted to the EIA by mail, fax, e-mail, or...

    U.S. Energy Information Administration (EIA) Indexed Site

    Failure to comply may result in criminal fines, civil penalties and other sanctions as provided by law. Title 18 USC 1001 makes it a criminal offense for any person knowingly and ...

  1. This form may be submitted to the EIA by mail, fax, e-mail, or...

    U.S. Energy Information Administration (EIA) Indexed Site

    "REPORT YEAR 2011" "This report is mandatory under Public Law 93-275. Failure to comply may result in criminal fines, civil penalties and other sanctions as provided by law. ...

  2. Alternative Compliance: Guidelines for Preparing and Submitting a Waiver Request Application and Other Documentation Requirements (Book)

    SciTech Connect (OSTI)

    Not Available

    2010-11-01

    This document is designed to assist covered fleets interested in taking advantage of more flexible compliance options and to facilitate the transition from Standard Compliance to Alternative Compliance. It is designed to help fleets better understand the Alternative Compliance option and successfully complete the waiver application process.

  3. This form may be submitted to the EIA by mail, fax, e-mail, or...

    U.S. Energy Information Administration (EIA) Indexed Site

    business on the web.) To use this service, we recommend the use of Microsoft Internet Explorer 5.5 or later or Netscape 4.77 or later. Send your surveys using this secure...

  4. Petrography study of two siliceous limestones submitted to alkali-silica reaction

    SciTech Connect (OSTI)

    Monnin, Y. . E-mail: monnin@ensm-douai.fr; Degrugilliers, P.; Bulteel, D.; Garcia-Diaz, E.

    2006-08-15

    This study presents the contribution of petrography to the comprehension of the alkali-silica reaction mechanism applied to two siliceous limestones. A petrography study was made on the two aggregates before reaction to define their relative proportions and types of reactive silica and to observe their distribution in the microstructure. Then a model reactor, constituted by the reactive siliceous limestone aggregate, portlandite and NaOH, was used to measure the swelling due to reaction of the silica with alkalis and the free expansion of the aggregates. The volume evolution between both aggregates was very different and could be explained by the preliminary petrographic study. It appears that the swelling of the aggregates is conditioned by the microstructure of the carbonated matrix, the quantity and the distribution of the reactive silica.

  5. Submit Your Ideas for the NY Energy Data Jam | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Applications powered by open energy data were on display at the Energy Datapalooza in June 2012. | Photo by Sarah Gerrity, Energy Department. Applications powered by open energy ...

  6. Alternative Compliance: Guidelines for Preparing and Submitting a Waiver Request Application and Other Documentation Requirements (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2014-06-01

    This document is designed to assist covered fleets interested in taking advantage of more flexible compliance options and to facilitate the transition from Standard Compliance to Alternative Compliance. It is designed to help fleets better understand the Alternative Compliance option and successfully complete the waiver application process.

  7. Alternative Compliance: Guidelines for Preparing and Submitting a Waiver Request Application and Other Documentation Requirements

    SciTech Connect (OSTI)

    Not Available

    2013-03-01

    This document is designed to assist covered fleets interested in taking advantage of more flexible compliance options and to facilitate the transition from Standard Compliance to Alternative Compliance. It is designed to help fleets better understand the Alternative Compliance option and successfully complete the waiver application process.

  8. Alternative Compliance: Guidelines for Preparing and Submitting a Waiver Request Application and Other Documentation Requirements (Book)

    SciTech Connect (OSTI)

    Sears, T.

    2014-01-01

    This document is designed to assist covered fleets interested in taking advantage of more flexible compliance options and to facilitate the transition from Standard Compliance to Alternative Compliance. It is designed to help fleets better understand the Alternative Compliance option and successfully complete the waiver application process.

  9. Development of a Progeny Marker for Steelhead; A Thesis submitted to Oregon State University.

    SciTech Connect (OSTI)

    Shippentower, Gene E.

    2009-04-15

    This study was undertaken to determine if strontium chloride could be used to create a trans-generational otolith mark in steelhead (Oncorhynchus mykiss). I completed two strontium injection trials and a survey of juvenile steelhead from various steelhead hatcheries. The two trials measured Sr:Ca ratios in otoliths in response to injections and the survey measured the natural variation in Sr:Ca ratios in otoliths of juvenile hatchery steelhead in response to the natural variation. In 2003, adult female Wallowa River, Oregon O. mykiss, were captured at the hatchery and evenly divided between a control group and two treatment groups. These females received an intraperitoneal injection of 1cc/500 g of body weight of a physiologically isotonic solution (0.9% saline) containing concentrations of 0 (control), 1000, or 5000 parts per million (ppm) of strontium chloride hexahydrate (SrCl{sub 2}* 6H{sub 2}O). Females were housed in a single outdoor tank until spawned artificially, and a distinct external tag identified each female within each treatment group. In 2004, female steelhead were captured throughout the duration of the adult returns to the Umatilla River basin and injected with 0, 1000, 5000, or 20,000-ppm strontium. In both trials, progeny of fish treated with strontium had significantly higher Sr:Ca ratios in the primordial region of their otoliths as measured using an electron wavelength dispersive microprobe. There was no difference in fertilization rates of eggs and survival rates of fry among treatment groups. Progeny from treated mothers were on average larger than progeny of untreated mothers. The Sr:Ca ratios in otoliths collected from various populations of steelhead were greater than the control values measured in both injections studies. This study suggests that the marking technique works and the utility for such a technique could be used for empirical observations in determining the relative fitness of progeny of adult hatchery origin fish that spawn naturally. The variation in Sr:Ca ratios found among steelhead hatcheries suggests that care must be taken if the technique is employed where fish from more than one hatchery could potentially be involved.

  10. This form may be submitted to the EIA by mail, fax, e-mail, or...

    U.S. Energy Information Administration (EIA) Indexed Site

    ...www.eia.govsurveyformeia782alist782a.pdf" "Phone No.:",,,..."Ex... you are reporting:" "Type of Report (Check One):" ,,"Original",,,..."Mo",,,"Da...