Sample records for venezuela regulation induced

  1. The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis

    E-Print Network [OSTI]

    Niese, Kathryn A; Chiaramonte, Monica G; Ellies, Lesley G; Rothenberg, Marc E; Zimmermann, Nives

    2010-01-01T23:59:59.000Z

    acid transporter 2 is induced in inflammatory lung modelsand regulates lung fibrosis Respiratory Research 2010, 11:872 is induced in inflammatory lung models and regulates lung

  2. COLOMBIA GUYANA VENEZUELA FR.

    E-Print Network [OSTI]

    Columbia University

    PERU CHILE ARGENTINA PARAGUAY BOLIVIA COLOMBIA GUYANA SURINAME URUGUAY VENEZUELA FR. GUIANA POPULATION DENSITY, 2000 Population density measures the number of persons per square kilometer of land area the population grids and thus may appear coarse. Lambert Azimuthal Equal Area Projection ´ 0 500 1,000 km

  3. Hctor L. Palacios Verdes Caracas, Venezuela

    E-Print Network [OSTI]

    Palacios, Héctor

    Héctor L. Palacios Verdes Caracas, Venezuela Phone: ask Email: hectorpal@gmail.com Web page: http://www.ldc.usb.ve/~hlp Citizen: Venezuela Residence: Venezuela Education Ph. D. Informatics and Digital Communication December. Caracas, Venezuela. Thesis: Planning as Branch and Bound: a Constraint Programming implementation. Advisor

  4. E-Print Network 3.0 - acid regulates ozone-induced Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ozone-induced Search Powered by Explorit Topic List Advanced Search Sample search results for: acid regulates ozone-induced Page: << < 1 2 3 4 5 > >> 1 Plant Molecular Biology 51:...

  5. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK

    E-Print Network [OSTI]

    Sulzer, David

    Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and m protein accumulation as well as astrocyte function. In this study, we found that GFAP accumulation induces is negatively regulated by mammalian target of rapamycin (mTOR). The activation of p38 MAPK by GFAP accumulation

  6. Universidad Central de Venezuela Facultad de Ciencias

    E-Print Network [OSTI]

    Coto, Ernesto

    Universidad Central de Venezuela Facultad de Ciencias Escuela de Computación Una herramienta para. Universidad Central de Venezuela. {ecoto, hnavarro, omaira}@opalo.ciens.ucv.ve **Laboratorio TOOLS. Escuela de Computación. Facultad de Ciencias. Universidad Central de Venezuela. amatteo@isys.ciens.ucv.ve Caracas, Enero

  7. Universidad Central de Venezuela Facultad de Ciencias

    E-Print Network [OSTI]

    Coto, Ernesto

    Universidad Central de Venezuela Facultad de Ciencias Escuela de Computación Lecturas en Ciencias ecoto@strix.ciens.ucv.ve ecoto@opalo.ciens.ucv.ve Universidad Central de Venezuela. Facultad de Ciencias. Escuela de Computación. Laboratorio de Computación Gráfica (LCG) Venezuela. Caracas Apdo. 47002, 1041-A ND

  8. Universidad Central de Venezuela Facultad de Ciencias

    E-Print Network [OSTI]

    Coto, Ernesto

    Universidad Central de Venezuela Facultad de Ciencias Escuela de Computación Lecturas en Ciencias ecoto@strix.ciens.ucv.ve ecoto@opalo.ciens.ucv.ve Universidad Central de Venezuela. Facultad de Ciencias. Escuela de Computación. Laboratorio de Computación Gráfica (LCG) Venezuela. Caracas Apdo. 47002, 1041-A

  9. Universidad Central de Venezuela Facultad de Ciencias

    E-Print Network [OSTI]

    Coto, Ernesto

    Universidad Central de Venezuela Facultad de Ciencias Escuela de Computación Lecturas en Ciencias Construcción de Algoritmos Ernesto Coto ecoto@strix.ciens.ucv.ve Universidad Central de Venezuela. Facultad de Ciencias. Escuela de Computación. Laboratorio de Computación Gráfica (LCG) Venezuela. Caracas Apdo. 47002

  10. Universidad Central de Venezuela Facultad de Ciencias

    E-Print Network [OSTI]

    Coto, Ernesto

    Universidad Central de Venezuela Facultad de Ciencias Escuela de Computación Lecturas en Ciencias@opalo.ciens.ucv.ve Universidad Central de Venezuela. Facultad de Ciencias. Escuela de Computación. Laboratorio de Computación Gráfica (LCG) Venezuela. Caracas Apdo. 47002, 1041-A. ND 2003-02 Resumen Los grafos son solo abstracciones

  11. Universidad Central de Venezuela Facultad de Ciencias

    E-Print Network [OSTI]

    Astudillo, Reinaldo

    Universidad Central de Venezuela Facultad de Ciencias Escuela de Computación Lecturas en Ciencias) for some E Cn?n with E Venezuela Venezuela, Centro de C´alculo Cient´ifico y Tecnol´ogico, (zenaida.castillo@ciens.ucv.ve). 1 #12;2 R

  12. Engineered mRNA regulation using an inducible protein-RNA aptamer interaction

    E-Print Network [OSTI]

    Belmont, Brian J. (Brian Joshua)

    2012-01-01T23:59:59.000Z

    The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common regulatory mechanism uses inducible protein-RNA interactions to shape diverse aspects ...

  13. Engineering a Direct and Inducible Protein-RNA Interaction To Regulate RNA Biology

    E-Print Network [OSTI]

    Belmont, Brian Joshua

    The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common mechanism uses inducible protein?RNA interactions to shape diverse aspects of cellular ...

  14. The Importance of Regulation-Induced Innovation for Sustainable Development

    E-Print Network [OSTI]

    Ashford, Nicholas A.

    This article explores the complex relationship between environmental regulation, innovation, and sustainable development within the context of an increasingly globalizing economy. The economic development, environment, and ...

  15. MAGI-3 regulates LPA-induced activation of Erk and RhoA Huanchun Zhang a

    E-Print Network [OSTI]

    Hall, Randy A

    MAGI-3 regulates LPA-induced activation of Erk and RhoA Huanchun Zhang a , Dongsheng Wang a , Hong of Erk and Akt. In contrast, silencing of MAGI-3 expression by siRNA drastically inhibited LPA-induced Erk activation, suggesting that the lack of an effect by overexpression was due to the high endogenous

  16. Original article Regulation of inducible nitric oxide synthase

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    of the MCF- 7 human breast cancer cell line. The results showed that biochanin A treatment induced dose- and time- dependent inhibition on MCF-7 cell growth at concentrations above 20 µg.mL­1. An examination of treated MCF-7 cell morphology revealed condensation of the chromosome and dehydration of the cyto- plasm

  17. La enseanza teatral en Venezuela

    E-Print Network [OSTI]

    Rodrí guez, Orlando

    1988-04-01T23:59:59.000Z

    torias o permanentes, pero de escasa incidencia en el resultado final. La mayor parte de los estudios se ha dictado de manera vespertina, atendiendo la realidad de que el teatro en Venezuela hasta el da de hoy, y quizs con contadas excepciones... intentara recuperar el tiempo perdido y superar el retraso en relacin con otros pases del continente. Comenz entonces la entrada del pas en la moderna realidad escnica del siglo actual. Para ello, la llegada de valores originarios de Espaa, Mxico...

  18. TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension

    E-Print Network [OSTI]

    MacMillan, Andrew

    3 is the primary TIMP to regulate agonist- induced vascular remodelling and hypertension Ratnadeep Hypertension is accompanied by structural remodelling of vascular extracellular matrix (ECM). Tissue inhibitor. In response to a hypertensive stimulus, the balance between MMPs and TIMPs is altered. We examined the role

  19. Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells

    E-Print Network [OSTI]

    Linial, Michal

    Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release kinase (ERK)/mitogen-activated protein kinase (MAPK) in pardaxin-induced dopamine (DA) release DA release. Time course exper- iments indicated that PX, at nontoxic concentrations, stimu- lated ERK

  20. PI3K/AKT and ERK regulate retinoic acid-induced neuroblastoma cellular differentiation

    SciTech Connect (OSTI)

    Qiao, Jingbo [Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 (United States)] [Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Paul, Pritha; Lee, Sora [Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 (United States) [Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Qiao, Lan; Josifi, Erlena; Tiao, Joshua R. [Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 (United States)] [Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Chung, Dai H., E-mail: dai.chung@vanderbilt.edu [Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 (United States)

    2012-08-03T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Retinoic acid (RA) induces neuroblastoma cells differentiation, which is accompanied by G0/G1 cell cycle arrest. Black-Right-Pointing-Pointer RA resulted in neuroblastoma cell survival and inhibition of DNA fragmentation; this is regulated by PI3K pathway. Black-Right-Pointing-Pointer RA activates PI3K and ERK1/2 pathway; PI3K pathway mediates RA-induced neuroblastoma cell differentiation. Black-Right-Pointing-Pointer Upregulation of p21 is necessary for RA-induced neuroblastoma cell differentiation. -- Abstract: Neuroblastoma, the most common extra-cranial solid tumor in infants and children, is characterized by a high rate of spontaneous remissions in infancy. Retinoic acid (RA) has been known to induce neuroblastoma differentiation; however, the molecular mechanisms and signaling pathways that are responsible for RA-mediated neuroblastoma cell differentiation remain unclear. Here, we sought to determine the cell signaling processes involved in RA-induced cellular differentiation. Upon RA administration, human neuroblastoma cell lines, SK-N-SH and BE(2)-C, demonstrated neurite extensions, which is an indicator of neuronal cell differentiation. Moreover, cell cycle arrest occurred in G1/G0 phase. The protein levels of cyclin-dependent kinase inhibitors, p21 and p27{sup Kip}, which inhibit cell proliferation by blocking cell cycle progression at G1/S phase, increased after RA treatment. Interestingly, RA promoted cell survival during the differentiation process, hence suggesting a potential mechanism for neuroblastoma resistance to RA therapy. Importantly, we found that the PI3K/AKT pathway is required for RA-induced neuroblastoma cell differentiation. Our results elucidated the molecular mechanism of RA-induced neuroblastoma cellular differentiation, which may be important for developing novel therapeutic strategy against poorly differentiated neuroblastoma.

  1. PKC{eta} is a negative regulator of AKT inhibiting the IGF-I induced proliferation

    SciTech Connect (OSTI)

    Shahaf, Galit; Rotem-Dai, Noa; Koifman, Gabriela; Raveh-Amit, Hadas; Frost, Sigal A.; Livneh, Etta, E-mail: etta@bgu.ac.il

    2012-04-15T23:59:59.000Z

    The PI3K-AKT pathway is frequently activated in human cancers, including breast cancer, and its activation appears to be critical for tumor maintenance. Some malignant cells are dependent on activated AKT for their survival; tumors exhibiting elevated AKT activity show sensitivity to its inhibition, providing an Achilles heel for their treatment. Here we show that the PKC{eta} isoform is a negative regulator of the AKT signaling pathway. The IGF-I induced phosphorylation on Ser473 of AKT was inhibited by the PKC{eta}-induced expression in MCF-7 breast adenocarcinoma cancer cells. This was further confirmed in shRNA PKC{eta}-knocked-down MCF-7 cells, demonstrating elevated phosphorylation on AKT Ser473. While PKC{eta} exhibited negative regulation on AKT phosphorylation it did not alter the IGF-I induced ERK phosphorylation. However, it enhanced ERK phosphorylation when stimulated by PDGF. Moreover, its effects on IGF-I/AKT and PDGF/ERK pathways were in correlation with cell proliferation. We further show that both PKC{eta} and IGF-I confer protection against UV-induced apoptosis and cell death having additive effects. Although the protective effect of IGF-I involved activation of AKT, it was not affected by PKC{eta} expression, suggesting that PKC{eta} acts through a different route to increase cell survival. Hence, our studies show that PKC{eta} provides negative control on AKT pathway leading to reduced cell proliferation, and further suggest that its presence/absence in breast cancer cells will affect cell death, which could be of therapeutic value.

  2. Light-induced nuclear import of phytochrome-A:GFP fusion proteins is differentially regulated in transgenic tobacco

    E-Print Network [OSTI]

    Schfer, Eberhard

    Light-induced nuclear import of phytochrome-A:GFP fusion proteins is differentially regulated. Summary Phytochromes (phy) are a family of photoreceptors that control various aspects of light inductive light conditions and for the high irradiance response (HIR) under continuous far-red light. We

  3. The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans

    SciTech Connect (OSTI)

    Fierro-Gonzalez, Juan Carlos [Karolinska Institute, Center for Biosciences at NOVUM, Department of Biosciences and Nutrition, S-141 83 Huddinge (Sweden)] [Karolinska Institute, Center for Biosciences at NOVUM, Department of Biosciences and Nutrition, S-141 83 Huddinge (Sweden); Gonzalez-Barrios, Maria [Centro Andaluz de Biologia del Desarrollo (CABD-CSIC), Departamento de Fisiologia, Anatomia y Biologia Celular, Universidad Pablo de Olavide, E-41013 Sevilla (Spain)] [Centro Andaluz de Biologia del Desarrollo (CABD-CSIC), Departamento de Fisiologia, Anatomia y Biologia Celular, Universidad Pablo de Olavide, E-41013 Sevilla (Spain); Miranda-Vizuete, Antonio, E-mail: amirviz@upo.es [Centro Andaluz de Biologia del Desarrollo (CABD-CSIC), Departamento de Fisiologia, Anatomia y Biologia Celular, Universidad Pablo de Olavide, E-41013 Sevilla (Spain) [Centro Andaluz de Biologia del Desarrollo (CABD-CSIC), Departamento de Fisiologia, Anatomia y Biologia Celular, Universidad Pablo de Olavide, E-41013 Sevilla (Spain); Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, E-41013 Sevilla (Spain); Swoboda, Peter, E-mail: peter.swoboda@ki.se [Karolinska Institute, Center for Biosciences at NOVUM, Department of Biosciences and Nutrition, S-141 83 Huddinge (Sweden)] [Karolinska Institute, Center for Biosciences at NOVUM, Department of Biosciences and Nutrition, S-141 83 Huddinge (Sweden)

    2011-03-18T23:59:59.000Z

    Highlights: {yields} First in vivo data for thioredoxin in dietary-restriction-(DR)-induced longevity. {yields} Thioredoxin (trx-1) loss suppresses longevity of eat-2 mutant, a genetic DR model. {yields} trx-1 overexpression extends wild-type longevity, but not that of eat-2 mutant. {yields} Longevity by dietary deprivation (DD), a non-genetic DR model, requires trx-1. {yields} trx-1 expression in ASJ neurons of aging adults is increased in response to DD. -- Abstract: Dietary restriction (DR) is the only environmental intervention known to extend adult lifespan in a wide variety of animal models. However, the genetic and cellular events that mediate the anti-aging programs induced by DR remain elusive. Here, we used the nematode Caenorhabditis elegans to provide the first in vivo evidence that a thioredoxin (TRX-1) regulates adult lifespan extension induced by DR. We found that deletion of the gene trx-1 completely suppressed the lifespan extension caused by mutation of eat-2, a genetic surrogate of DR in the worm. However, trx-1 deletion only partially suppressed the long lifespan caused by mutation of the insulin-like receptor gene daf-2 or by mutation of the sensory cilia gene osm-5. A trx-1::GFP translational fusion expressed from its own promoter in ASJ neurons (Ptrx-1::trx-1::GFP) rescued the trx-1 deletion-mediated suppression of the lifespan extension caused by mutation of eat-2. This rescue was not observed when trx-1::GFP was expressed from the ges-1 promoter in the intestine. In addition, overexpression of Ptrx-1::trx-1::GFP extended lifespan in wild type, but not in eat-2 mutants. trx-1 deletion almost completely suppressed the lifespan extension induced by dietary deprivation (DD), a non-genetic, nutrient-based model of DR in the worm. Moreover, DD upregulated the expression of a trx-1 promoter-driven GFP reporter gene (Ptrx-1::GFP) in ASJ neurons of aging adults, but not that of control Pgpa-9::GFP (which is also expressed in ASJ neurons). We propose that DR activates TRX-1 in ASJ neurons during aging, which in turn triggers TRX-1-dependent mechanisms to extend adult lifespan in the worm.

  4. Study Abroad in Venezuela ON-SITE GUIDE 201415

    E-Print Network [OSTI]

    Minnesota, University of

    Study Abroad in Venezuela ON-SITE GUIDE 2014­15 S T U D Y A B R O A D THE AMERICAS #12;2 Important and can contact the on-site director if needed. In Venezuela VENUSA College 49-49 Avenida Urdaneta Edificio Guilam Mérida, Venezuela Phone: 58.274.263.7631 Fax: 58.274.263.3525 www.VENUSAcollege.org Francy

  5. alto orinoco venezuela: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Venezuela, aerial view looking north. important area of natural hazard research Eaton, L. Scott 118 Different methodologies for obtaining a permeability distribution in...

  6. Human Glucocorticoid-Induced TNF Receptor Ligand Regulates its Signaling Activity Through Multiple Oligomerization States

    SciTech Connect (OSTI)

    Zhou,Z.; Dong, X.; Berezov, A.; Zhang, G.; Li, Y.; Zhang, H.; Murali, R.; Li, B.; Greene, M.

    2008-01-01T23:59:59.000Z

    Ligation between glucocorticoid-induced tumor necrosis factor receptor (GITR) and its ligand (GITRL) provides an undefined signal that renders CD4+CD25- effector T cells resistant to the inhibitory effects of CD4+CD25+ regulatory T cells. To understand the structural basis of GITRL function, we have expressed and purified the extracellular domain of human GITR ligand in Escherichia coli. Chromotography and cross-linking studies indicate that human GITRL (hGITRL) exists as dimers and trimers in solution and also can form a supercluster. To gain insight into the nature of GITRL oligomerization, we determined the crystallographic structures of hGITRL, which revealed a loosely associated open trimer with a deep cavity at the molecular center and a flexible C-terminal tail bent for trimerization. Moreover, a tetramer of trimers (i.e., supercluster) has also been observed in the crystal, consistent with the cross-linking analysis. Deletion of the C-terminal distal three residues disrupts the loosely assembled trimer and favors the formation of a dimer that has compromised receptor binding and signaling activity. Collectively, our studies identify multiple oligomeric species of hGITRL that possess distinct kinetics of ERK activation. The studies address the functional implications and structural models for a process by which hGITRL utilizes multiple oligomerization states to regulate GITR-mediated signaling during T cell costimulation.

  7. Venezuela: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTri Global EnergyUtility Rate HomeVela Jump to: navigation,Venezuela:

  8. Bachaquero-01 reservoir, Venezuela-increasing oil production by switching from cyclic steam injection to steamflooding using horizontal wells

    E-Print Network [OSTI]

    Rodriguez, Manuel Gregorio

    1999-01-01T23:59:59.000Z

    The Bachaquero-01 reservoir of the Lagunillas field is located in the eastern part of the Maracaibo Lake, Venezuela. The field is operated by the national oil company of Venezuela, PDVSA (Petroleos de Venezuela, S.A.). The ...

  9. Tax effects upon oil field development in Venezuela

    E-Print Network [OSTI]

    Manzano, Osmel

    2000-01-01T23:59:59.000Z

    Important reforms have been made to the oil sector tax code in Venezuela. Given its diversity of oil resources, there was a concern that some resources were not being exploited because of the structure of the tax code. ...

  10. A reservoir management strategy for multilayered reservoirs in eastern Venezuela

    E-Print Network [OSTI]

    Espinel Diaz, Arnaldo Leopoldo

    1998-01-01T23:59:59.000Z

    A reservoir management strategy has been developed for a field located in eastern Venezuela. The field contains deep, high pressure, multilayer reservoirs. A thorough formation evaluation was accomplished using the log data, core data, PVT data...

  11. An investigation of rainfall variability and distribution in Venezuela

    E-Print Network [OSTI]

    Gibson, Donald Reid

    1968-01-01T23:59:59.000Z

    America land forms (Z) the orientation of the general wind pattern with respect to the coast; and (3) polar air masses invading the country from both hemispheres. The Objective The objective of this study is to investigate monthly and daily patterns... of precipitation in the northern part of Venezuela, At the present time, precipitation patterns in Venezuela give the best indication of the weather systems. The other principal elements of climate that are observed are temper- ature, pressure, humidity, wind...

  12. La Repblica y las Letras literatura y carcter nacional en Brasil y Venezuela

    E-Print Network [OSTI]

    Oliveira, Emanuelle K. F.

    1995-01-01T23:59:59.000Z

    o mito da revoluo no Brasil (1897- francesa e a formaoy carcter nacional en Brasil y Venezuela* Introduccin LaEl adentro es la nacin (Brasil y Venezuela), pero este

  13. Residential energy use and conservation in Venezuela: Results and implications of a household survey in Caracas

    SciTech Connect (OSTI)

    Figueroa, M.J.; Ketoff, A.; Masera, O.

    1992-10-01T23:59:59.000Z

    This document presents the final report of a study of residential energy use in Caracas, the capital of Venezuela. It contains the findings of a household energy-use survey held in Caracas in 1988 and examines options for introducing energy conservation measures in the Venezuelan residential sector. Oil exports form the backbone of the Venezuelan economy. Improving energy efficiency in Venezuela will help free domestic oil resources that can be sold to the rest of the world. Energy conservation will also contribute to a faster recovery of the economy by reducing the need for major investments in new energy facilities, allowing the Venezuelan government to direct its financial investments towards other areas of development. Local environmental benefits will constitute an important additional by-product of implementing energy-efficiency policies in Venezuela. Caracas`s residential sector shows great potential for energy conservation. The sector is characterized by high saturation levels of major appliances, inefficiency of appliances available in the market, and by careless patterns of energy use. Household energy use per capita average 6.5 GJ/per year which is higher than most cities in developing countries; most of this energy is used for cooking. Electricity accounts for 41% of all energy use, while LPG and natural gas constitute the remainder. Specific options for inducing energy conservation and energy efficiency in Caracas`s residential sector include energy-pricing policies, fuel switching, particularly from electricity to gas, improving the energy performance of new appliances and customer information. To ensure the accomplishment of an energy-efficiency strategy, a concerted effort by energy users, manufacturers, utility companies, government agencies, and research institutions will be needed.

  14. Inhibition of the ERK phosphorylation plays a role in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells

    SciTech Connect (OSTI)

    Ho, P.-Y. [Graduate Institute of Cell and Molecular Biology, Taipei Medical University, Taipei, Taiwan (China); Hsu, S.-P. [Institute of Physiology, College of Medicine, National Taiwan University, Taiwan (China); Liang, Y.-C. [Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan (China); Kuo, M.-L. [Institute of Toxicology, College of Medicine, National Taiwan University, Taiwan (China); Ho, Y.-S. [Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan (China); Lee, W.-S. [Graduate Institute of Neuroscience, Taipei Medical University, Taipei, Taiwan (China); Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan (China); Department of Physiology, Medical College, Taipei Medical University, Taipei, Taiwan (China)], E-mail: wslee@tmu.edu.tw

    2008-05-15T23:59:59.000Z

    Previously, we showed that terbinafine (TB) induces cell-cycle arrest in cultured human umbilical vein endothelial cells (HUVEC) through an up-regulation of the p21 protein. The aim of this study is to delineate the molecular mechanisms underlying TB-induced increase of p21 protein. RT-PCR analysis demonstrated that the mRNA levels of p21 and p53 were increased in the TB-treated HUVEC. The p21 promoter activity was also increased by TB treatment. Transfection of HUVEC with p53 dominant negative (DN) abolished the TB-induced increases of p21 promoter activity and protein level, suggesting that the TB-induced increase of p21 is p53-dependent. Western blot analysis demonstrated that TB decreased the levels of phosphorylated extracellular signal-regulated kinase (ERK). Over-expression of mitogen-activated protein kinase (MEK)-1, the immediate upstream activator kinase of ERK, abolished the TB-induced increases of p21 and p53 protein and decrease of thymidine incorporation. The ERK inhibitor (PD98059) enhanced the TB-induced inhibition of thymidine incorporation into HUVEC. Taken together, these data suggest that the decrease of ERK activity plays a role in the TB-induced up-regulation of p21 in HUVEC. On the other hand, pretreatment of the cells with geranylgeraniol (GGOH), farnesol (FOH), or Ras inhibitor peptide did not affect the TB-induced decrease of thymidine incorporation. Taken together, our results suggest that TB might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21 expression and cell-cycle arrest.

  15. Re-Regulating the Mexican Gulf

    E-Print Network [OSTI]

    Zalik, Anna

    2006-01-01T23:59:59.000Z

    energy sovereignty as manifest in Venezuelas recent endorsement of Petroleo Caribe as well as in Bolivia

  16. TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways

    SciTech Connect (OSTI)

    Fang, Ling, E-mail: fangling_1984@126.com; Zhan, Shuxiang; Huang, Cheng; Cheng, Xi; Lv, Xiongwen; Si, Hongfang; Li, Jun, E-mail: lj@ahmu.edu.cn

    2013-11-01T23:59:59.000Z

    TRPM7, a non-selective cation channel of the TRP channel superfamily, is implicated in diverse physiological and pathological processes including cell proliferation. Recently, TRPM7 has been reported in hepatic stellate cells (HSCs). Here, we investigated the contribution role of TRPM7 in activated HSC-T6 cell (a rat hepatic stellate cell line) proliferation. TRPM7 mRNA and protein were measured by RT-PCR and Western blot in rat model of liver fibrosis in vivo and PDGF-BB-activated HSC-T6 cells in vitro. Both mRNA and protein of TRPM7 were dramatically increased in CCl{sub 4}-treated rat livers. Stimulation of HSC-T6 cells with PDGF-BB resulted in a time-dependent increase of TRPM7 mRNA and protein. However, PDGF-BB-induced HSC-T6 cell proliferation was inhibited by non-specific TRPM7 blocker 2-aminoethoxydiphenyl borate (2-APB) or synthetic siRNA targeting TRPM7, and this was accompanied by downregulation of cell cycle proteins, cyclin D1, PCNA and CDK4. Blockade of TRPM7 channels also attenuated PDGF-BB induced expression of myofibroblast markers as measured by the induction of ?-SMA and Col1?1. Furthermore, the phosphorylation of ERK and AKT, associated with cell proliferation, decreased in TRPM7 deficient HSC-T6 cells. These observations suggested that TRPM7 channels contribute to perpetuated fibroblast activation and proliferation of PDGF-BB induced HSC-T6 cells via the activation of ERK and PI3K pathways. Therefore, TRPM7 may constitute a useful target for the treatment of liver fibrosis. - Highlights: Upregulation of TRPM7 mRNA and protein in the fibrotic livers from CCl{sub 4}-treated rats. Increasing expression of TRPM7 mRNA and protein during HSC activation. Blockade of TRPM7 inhibited the PDGF-BB induced proliferation of HSC-T6 cells. Blockade of TRPM7 decreased ?-SMA and Col1?1 expressions in activated HSC-T6 cells. TRPM7 up-regulation contributes to the activation of ERK and AKT pathways.

  17. Magnetically-Regulated Fragmentation Induced by Nonlinear Flows and Ambipolar Diffusion

    E-Print Network [OSTI]

    Shantanu Basu; Glenn E. Ciolek; Wolf Dapp; James Wurster

    2009-01-14T23:59:59.000Z

    We present a parameter study of simulations of fragmentation regulated by gravity, magnetic fields, ambipolar diffusion, and nonlinear flows. The thin-sheet approximation is employed with periodic lateral boundary conditions, and the nonlinear flow field ("turbulence") is allowed to freely decay. In agreement with previous results in the literature, our results show that the onset of runaway collapse (formation of the first star) in subcritical clouds is significantly accelerated by nonlinear flows in which a large-scale wave mode dominates the power spectrum. In addition, we find that a power spectrum with equal energy on all scales also accelerates collapse, but by a lesser amount. For a highly super-Alfvenic initial velocity field with most power on the largest scales, the collapse occurs promptly during the initial compression wave. However, for trans-Alfvenic perturbations, a subcritical magnetic field causes a rebound from the initial compression, and the system undergoes several oscillations before runaway collapse occurs. Models that undergo prompt collapse have highly supersonic infall motions at the core boundaries. Cores in magnetically subcritical models with trans-Alfvenic initial perturbations also pick up significant systematic speeds by inheriting motions associated with magnetically-driven oscillations. Core mass distributions are much broader than in models with small-amplitude initial perturbations, although the disturbed structure of cores that form due to nonlinear flows does not guarantee subsequent monolithic collapse. Our simulations also demonstrate that significant power can (if present initially) be maintained with negligible dissipation in large-scale compressive modes of a magnetic thin sheet, in the limit of perfect flux freezing.

  18. Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells

    SciTech Connect (OSTI)

    Zhang, Chi; Yuan, Xian-rui; Li, Hao-yu; Zhao, Zi-jin; Liao, Yi-wei; Wang, Xiang-yu; Su, Jun; Sang, Shu-shan; Liu, Qing, E-mail: xiangyaliuqing@163.com

    2014-01-03T23:59:59.000Z

    Highlights: Downregulation of Drp-1 attenuates glutamate-induced excitotoxicity. Downregulation of Drp-1 inhibits glutamate-induced apoptosis. Downregulation of Drp-1 reduces glutamate-induced mitochondrial dysfunction. Downregulation of Drp-1 preserves intracellular calcium homeostasis. -- Abstract: Glutamate-mediated excitotoxicity is involved in many acute and chronic brain diseases. Dynamin related protein 1 (Drp-1), one of the GTPase family of proteins that regulate mitochondrial fission and fusion balance, is associated with apoptotic cell death in cancer and neurodegenerative diseases. Here we investigated the effect of downregulating Drp-1 on glutamate excitotoxicity-induced neuronal injury in HT22 cells. We found that downregulation of Drp-1 with specific small interfering RNA (siRNA) increased cell viability and inhibited lactate dehydrogenase (LDH) release after glutamate treatment. Downregulation of Drp-1 also inhibited an increase in the Bax/Bcl-2 ratio and cleavage of caspase-9 and caspase-3. Drp-1 siRNA transfection preserved the mitochondrial membrane potential (MMP), reduced cytochrome c release, enhanced ATP production, and partly prevented mitochondrial swelling. In addition, Drp-1 knockdown attenuated glutamate-induced increases of cytoplasmic and mitochondrial Ca{sup 2+}, and preserved the mitochondrial Ca{sup 2+} buffering capacity after excitotoxicity. Taken together, these results suggest that downregulation of Drp-1 protects HT22 cells against glutamate-induced excitatory damage, and this neuroprotection may be dependent at least in part on the preservation of mitochondrial function through regulating intracellular calcium homeostasis.

  19. astrobiology caracas venezuela: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    astrobiology caracas venezuela First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 UNIVERSIDAD SIMN BOLVAR...

  20. Human p38{delta} MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14

    SciTech Connect (OSTI)

    Ozawa, Shigeyuki [Oral Health Science Research Center (Japan) [Oral Health Science Research Center (Japan); Department of Biochemistry and Molecular Biology (Japan); Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka 238-8580 (Japan); Ito, Shin; Kato, Yasumasa [Oral Health Science Research Center (Japan) [Oral Health Science Research Center (Japan); Department of Biochemistry and Molecular Biology (Japan); Kubota, Eiro [Department of Biochemistry and Molecular Biology (Japan) [Department of Biochemistry and Molecular Biology (Japan); Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka 238-8580 (Japan); Hata, Ryu-Ichiro, E-mail: ryuhata@gmail.com [Oral Health Science Research Center (Japan) [Oral Health Science Research Center (Japan); Department of Biochemistry and Molecular Biology (Japan)

    2010-06-11T23:59:59.000Z

    The mitogen-activated protein kinase (MAPK) family comprises ERK, JNK, p38 and ERK5 (big-MAPK, BMK1). UV irradiation of squamous cell carcinoma cells induced up-regulation of gene expression of chemokine BRAK/CXCL14, stimulated p38 phosphorylation, and down-regulated the phosphorylation of ERK. Human p38 MAPKs exist in 4 isoforms: p38{alpha}, {beta}, {gamma} and {delta}. The UV stimulation of p38 phosphorylation was not inhibited by the presence of SB203580 or PD169316, inhibitors of p38{alpha} and {beta}, suggesting p38 phosphorylation was not dependent on these 2 isoforms and that p38{gamma} and/or {delta} was responsible for the phosphorylation. In fact, inhibition of each of these 4 p38 isoforms by the introduction of short hairpin (sh) RNAs for respective isoforms revealed that only shRNA for p38{delta} attenuated the UV-induced up-regulation of BRAK/CXCL14 gene expression. In addition, over-expression of p38 isoforms in the cells showed the association of p38{delta} with ERK1 and 2, concomitant with down-regulation of ERK phosphorylation. The usage of p38{delta} isoform by UV irradiation is not merely due to the abundance of this p38 isoform in the cells. Because serum deprivation of the cells also induced an increase in BRAK/CXCL14 gene expression, and in this case p38{alpha} and/or {beta} isoform is responsible for up-regulation of BRAK/CXCL14 gene expression. Taken together, the data indicate that the respective stress-dependent action of p38 isoforms is responsible for the up-regulation of the gene expression of the chemokine BRAK/CXCL14.

  1. Hypochlorous acid and hydrogen peroxide-induced negative regulation of Salmonella enterica serovar Typhimurium ompW by the response regulator ArcA

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    Hypochlorous acid and hydrogen peroxide-induced negative5. Thomas E: Myeloperoxidase: Hydrogen Peroxide, ChlorideUse the Myeloperoxidase-Hydrogen Peroxide-Chloride System to

  2. Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-{beta}1 up-regulation in proximal tubular epithelial cells

    SciTech Connect (OSTI)

    Yang, Won Seok; Chang, Jai Won [Division of Nephrology, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul (Korea, Republic of)] [Division of Nephrology, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul (Korea, Republic of); Han, Nam Jeong [Department of Cell Biology, Asan Institute for Life Sciences, Seoul (Korea, Republic of)] [Department of Cell Biology, Asan Institute for Life Sciences, Seoul (Korea, Republic of); Lee, Sang Koo [Division of Nephrology, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul (Korea, Republic of)] [Division of Nephrology, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul (Korea, Republic of); Park, Su-Kil, E-mail: skpark@amc.seoul.kr [Division of Nephrology, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul (Korea, Republic of)] [Division of Nephrology, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul (Korea, Republic of)

    2012-09-10T23:59:59.000Z

    The role of spleen tyrosine kinase (Syk) in high glucose-induced intracellular signal transduction has yet to be elucidated. We investigated whether Syk is implicated in high glucose-induced transforming growth factor-{beta}1 (TGF-{beta}1) up-regulation in cultured human proximal tubular epithelial cells (HK-2 cell). High glucose increased TGF-{beta}1 gene expression through Syk, extracellular signal-regulated kinase (ERK), AP-1 and NF-{kappa}B. High glucose-induced AP-1 DNA binding activity was decreased by Syk inhibitors and U0126 (an ERK inhibitor). Syk inhibitors suppressed high glucose-induced ERK activation, whereas U0126 had no effect on Syk activation. High glucose-induced NF-{kappa}B DNA binding activity was also decreased by Syk inhibitors. High glucose increased nuclear translocation of p65 without serine phosphorylation of I{kappa}B{alpha} and without degradation of I{kappa}B{alpha}, but with an increase in tyrosine phosphorylation of I{kappa}B{alpha} that may account for the activation of NF-{kappa}B. Both Syk inhibitors and Syk-siRNA attenuated high glucose-induced I{kappa}B{alpha} tyrosine phosphorylation and p65 nuclear translocation. Depletion of p21-activated kinase 2 (Pak2) by transfection of Pak2-siRNA abolished high glucose-induced Syk activation. In summary, high glucose-induced TGF-{beta}1 gene transcription occurred through Pak2, Syk and subsequent ERK/AP-1 and NF-{kappa}B pathways. This suggests that Syk might be implicated in the diabetic kidney disease.

  3. DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation

    SciTech Connect (OSTI)

    Li, C.-C.; Lii, C.-K.; Liu, K.-L. [Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan (China); Yang, J.-J. [School of Dentistry, Chung Shan Medical University, Taichung, Taiwan (China); Chen, H.-W. [Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan (China)], E-mail: hawwen@csmu.edu.tw

    2007-12-15T23:59:59.000Z

    The constitutive androstane receptor (CAR) plays an important role in regulating the expression of detoxifying enzymes, including cytochrome P450 2B (CYP 2B). Phenobarbital (PB) induction of human CYP 2B6 and mouse CYP 2b10 has been shown to be mediated by CAR. Our previous study showed that PB-induced CYP 2B1 expression in rat primary hepatocytes is down-regulated by both n-6 and n-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA); however, the mechanism for this down-regulation by DHA was previously unknown. The objective of the present study was to determine whether change in CAR translocation is involved in the down-regulation by n-6 and n-3 PUFAs of PB-induced CYP 2B1 expression in rat primary hepatocytes. We used 100 {mu}M arachidonic acid, linoleic acid, eicosapentaenoic acid, and DHA to test this hypothesis. PB triggered the translocation of CAR from the cytosol into the nucleus in a dose-dependent and time-dependent manner in our hepatocyte system, and the CAR distribution in rat primary hepatocytes was significantly affected by DHA. DHA treatment decreased PB-inducible accumulation of CAR in the nuclear fraction and increased it in the cytosolic fraction in a dose-dependent manner. The down-regulation of CYP 2B1 expression by DHA occurred in a dose-dependent manner, and a similar pattern was found for the nuclear accumulation of CAR. The results of immunoprecipitation showed a CAR/RXR heterodimer bound to nuclear receptor binding site 1 (NR-1) of the PB-responsive enhancer module (PBREM) of the CYP 2B1gene. The EMSA results showed that PB-induced CAR binding to NR-1 was attenuated by DHA. Taken together, these results suggest that attenuation of CAR translocation and decreased subsequent binding to NR-1 are involved in DHA's down-regulation of PB-induced CYP 2B1 expression.

  4. Sesin 3 -Sistemas Distribuidos y Aplicaciones Mdicas 89 Escuela de Computacin Universidad Central de Venezuela UCV

    E-Print Network [OSTI]

    Coto, Ernesto

    Central de Venezuela UCV #12;II Simposio Científico y Tecnológico en Computación 201290 Escuela de Computación Universidad Central de Venezuela UCV #12;Sesión 3 - Sistemas Distribuidos y Aplicaciones Médicas 91 Escuela de Computación Universidad Central de Venezuela UCV #12;II Simposio Científico y

  5. E-Print Network 3.0 - aragua state venezuela Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Grosso State in Brazil (Fig. 3; Cabrera 1957; Eisenberg and Redford 1999; Jones... , in Suriname, Peru, and Venezuela (Guerrero 1996; Wenzel 1976). BEHAVIOR. In French Guiana,...

  6. E-Print Network 3.0 - amazonas state venezuela Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: Fig. 6).--VENEZUELA: Amazonas, BuenaVista, RioCasiquiare (Sanborn, 1937). SURINAME: Para, Zanderij... . Marginal localities of record (South America only, see Fig....

  7. Bachaquero-01 reservoir, Venezuela-increasing oil production by switching from cyclic steam injection to steamflooding using horizontal wells

    E-Print Network [OSTI]

    Rodriguez, Manuel Gregorio

    1999-01-01T23:59:59.000Z

    The Bachaquero-01 reservoir of the Lagunillas field is located in the eastern part of the Maracaibo Lake, Venezuela. The field is operated by the national oil company of Venezuela, PDVSA (Petroleos de Venezuela, S.A.). The Bachaquero-01 heavy oil...

  8. Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3

    SciTech Connect (OSTI)

    Tu, Yihui [Department of Orthopaedics, Yangpu District Central Hospital Affiliated to Tongji University School of Medicine, 450 Tengyue Road, Shanghai (China)] [Department of Orthopaedics, Yangpu District Central Hospital Affiliated to Tongji University School of Medicine, 450 Tengyue Road, Shanghai (China); Xue, Huaming [Department of Orthopaedics, Yangpu District Central Hospital Affiliated to Tongji University School of Medicine, 450 Tengyue Road, Shanghai (China) [Department of Orthopaedics, Yangpu District Central Hospital Affiliated to Tongji University School of Medicine, 450 Tengyue Road, Shanghai (China); Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom); Francis, Wendy [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom)] [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom); Davies, Andrew P. [Department of Orthopaedics and Trauma, Moriston Hospital, Swansea (United Kingdom)] [Department of Orthopaedics and Trauma, Moriston Hospital, Swansea (United Kingdom); Pallister, Ian; Kanamarlapudi, Venkateswarlu [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom)] [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom); Xia, Zhidao, E-mail: zhidao.xia@gmail.com [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom)] [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom)

    2013-11-08T23:59:59.000Z

    Highlights: Dex exerts dose-dependant inhibition of HACs viability and induction of apoptosis. Dex-induced impairment of chondrocytes was attenuated by rhLF. ERK and FASL/FAS signaling are involved in the effects of rhLF. OA patients with glucocorticoid-induced cartilage damage may benefit from treatment with rhLF. -- Abstract: Dexamethasone (Dex) is commonly used for osteoarthritis (OA) with excellent anti-inflammatory and analgesic effect. However, Dex also has many side effects following repeated use over prolonged periods mainly through increasing apoptosis and inhibiting proliferation. Lactoferrin (LF) exerts significantly anabolic effect on many cells and little is known about its effect on OA chondrocytes. Therefore, the aim of this study is to investigate whether LF can inhibit Dex-induced OA chondrocytes apoptosis and explore its possible molecular mechanism involved in. MTT assay was used to determine the optimal concentration of Dex and recombinant human LF (rhLF) on chondrocytes at different time and dose points. Chondrocytes were then stimulated with Dex in the absence or presence of optimal concentration of rhLF. Cell proliferation and viability were evaluated using MTT and LIVE/DEAD assay, respectively. Cell apoptosis was evaluated by multi-parameter apoptosis assay kit using both confocal microscopy and flow cytometry, respectively. The expression of extracellular signal-regulated kinase (ERK), FAS, FASL, and Caspase-3 (CASP3) at the mRNA and protein levels were examined by real-time polymerase chain reaction (PCR) and immunocytochemistry, respectively. The optimal concentration of Dex (25 ?g/ml) and rhLF (200 ?g/ml) were chosen for the following experiments. rhLF significantly reversed the detrimental effect of Dex on chondrocytes proliferation, viability, and apoptosis. In addition, rhLF significantly prevented Dex-induced down-regulation of ERK and up-regulation of FAS, FASL, and CASP3. These findings demonstrated that rhLF acts as an anabolic effect on chondrocytes through significantly reversing Dex-induced chondrocytes apoptosis. This study may contribute to further investigating the clinical application of LF on OA.

  9. Library Regulations Library Regulations

    E-Print Network [OSTI]

    Birmingham, University of

    Library Regulations 2012-13 Library Regulations UNIVERSITY OF BIRMINGHAM REGULATIONS LIBRARY REGULATIONS Preamble: The Library Regulations apply to all users of library facilities managed on behalf of the University by Library Services, and thus there are sections that apply also to non- members of the University

  10. Identification and characterization of Hydraulic Flow Units in the San Juan Formation, Orocual Field, Venezuela

    E-Print Network [OSTI]

    Deghirmandjian, Odilia

    2001-01-01T23:59:59.000Z

    This thesis focuses on the integration of core and well log data in order to provide a petrophysical characterization of the Hydraulic Flow Units (HFU) in the San Juan Formation, Orocual Field, Venezuela. We used three ...

  11. Fertility and rate of growth in a beef cattle herd in the 0rient of Venezuela

    E-Print Network [OSTI]

    Gonzalez Crespo, Justo Nicolas

    1978-01-01T23:59:59.000Z

    to express his utmost gratitude to Venezuela for giving him the opportunity to work toward the Master of Science degree through a scholarship of the Consejo Nacional de Investigaciones Cientzficas (CONICIT) and the Universidad de Oriente. Special...

  12. Characterization of Habitat for Hawksbill Turtle (Eretmochelys imbricata) in Los Roques Archipelago National Park, Venezuela

    E-Print Network [OSTI]

    Hunt, Luciana E.

    2010-10-12T23:59:59.000Z

    , VENEZUELA A Thesis by LUCIANA ESTELA HUNT Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, William D. Heyman... Roques Archipelago National Park, Venezuela. (August 2009) Luciana Estela Hunt, B.S., Universidad Nacional Agraria la Molina, Peru Chair of Advisory Committee: Dr. William D. Heyman Information on the locations for feeding, reproductions...

  13. Roles of Sensory Nerves in the Regulation of Radiation-Induced Structural and Functional Changes in the Heart

    SciTech Connect (OSTI)

    Sridharan, Vijayalakshmi; Tripathi, Preeti [Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Sharma, Sunil [Department of Radiation Oncology, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Moros, Eduardo G. [Department of Radiation Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida (United States); Zheng, Junying [Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Hauer-Jensen, Martin [Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Surgical Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas (United States); Boerma, Marjan, E-mail: mboerma@uams.edu [Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States)

    2014-01-01T23:59:59.000Z

    Purpose: Radiation-induced heart disease (RIHD) is a chronic severe side effect of radiation therapy of intrathoracic and chest wall tumors. The heart contains a dense network of sensory neurons that not only are involved in monitoring of cardiac events such as ischemia and reperfusion but also play a role in cardiac tissue homeostasis, preconditioning, and repair. The purpose of this study was to examine the role of sensory nerves in RIHD. Methods and Materials: Male Sprague-Dawley rats were administered capsaicin to permanently ablate sensory nerves, 2 weeks before local image-guided heart x-ray irradiation with a single dose of 21 Gy. During the 6 months of follow-up, heart function was assessed with high-resolution echocardiography. At 6 months after irradiation, cardiac structural and molecular changes were examined with histology, immunohistochemistry, and Western blot analysis. Results: Capsaicin pretreatment blunted the effects of radiation on myocardial fibrosis and mast cell infiltration and activity. By contrast, capsaicin pretreatment caused a small but significant reduction in cardiac output 6 months after irradiation. Capsaicin did not alter the effects of radiation on cardiac macrophage number or indicators of autophagy and apoptosis. Conclusions: These results suggest that sensory nerves, although they play a predominantly protective role in radiation-induced cardiac function changes, may eventually enhance radiation-induced myocardial fibrosis and mast cell activity.

  14. Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3{beta}

    SciTech Connect (OSTI)

    Choi, Cheol-Hee [Research Center for Resistant Cells, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of) [Research Center for Resistant Cells, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of); Department of Pharmacology, College of Medicine, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of); Lee, Byung-Hoon [College of Pharmacy and Multiscreening Center for Drug Development, Seoul National University, Seoul 151-742 (Korea, Republic of)] [College of Pharmacy and Multiscreening Center for Drug Development, Seoul National University, Seoul 151-742 (Korea, Republic of); Ahn, Sang-Gun [Department of Pathology, College of Dentistry, Chosun University, Gwangju 501-759 (Korea, Republic of)] [Department of Pathology, College of Dentistry, Chosun University, Gwangju 501-759 (Korea, Republic of); Oh, Seon-Hee, E-mail: oshccw@hanmail.net [Research Center for Resistant Cells, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of)] [Research Center for Resistant Cells, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of)

    2012-02-24T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer MG132 induces the phosphorylation of GSK3{beta}{sup Ser9} and, to a lesser extent, of GSK3{beta}{sup Thr390}. Black-Right-Pointing-Pointer MG132 induces dephosphorylation of p70S6K{sup Thr389} and phosphorylation of p70S6K{sup Thr421/Ser424}. Black-Right-Pointing-Pointer Inactivation of p38 dephosphorylates GSK3{beta}{sup Ser9} and phosphorylates GSK3{beta}{sup Thr390}. Black-Right-Pointing-Pointer Inactivation of p38 phosphorylates p70S6K{sup Thr389} and increases the phosphorylation of p70S6K{sup Thr421/Ser424}. Black-Right-Pointing-Pointer Inactivation of p38 decreases autophagy and increases apoptosis induced by MG132. -- Abstract: Proteasome inhibition is a promising approach for cancer treatment; however, the underlying mechanisms involved have not been fully elucidated. Here, we show that proteasome inhibition-induced p38 mitogen-activated protein kinase regulates autophagy and apoptosis by modulating the phosphorylation status of glycogen synthase kinase 3{beta} (GSK3{beta}) and 70 kDa ribosomal S6 kinase (p70S6K). The treatment of MDA-MB-231 cells with MG132 induced endoplasmic reticulum stress through the induction of ATF6a, PERK phosphorylation, and CHOP, and apoptosis through the cleavage of Bax and procaspase-3. MG132 caused the phosphorylation of GSK3{beta} at Ser{sup 9} and, to a lesser extent, Thr{sup 390}, the dephosphorylation of p70S6K at Thr{sup 389}, and the phosphorylation of p70S6K at Thr{sup 421} and Ser{sup 424}. The specific p38 inhibitor SB203080 reduced the p-GSK3{beta}{sup Ser9} and autophagy through the phosphorylation of p70S6K{sup Thr389}; however, it augmented the levels of p-ERK, p-GSK3{beta}{sup Thr390}, and p-70S6K{sup Thr421/Ser424} induced by MG132, and increased apoptotic cell death. The GSK inhibitor SB216763, but not lithium, inhibited the MG132-induced phosphorylation of p38, and the downstream signaling pathway was consistent with that in SB203580-treated cells. Taken together, our data show that proteasome inhibition regulates p38/GSK{sup Ser9}/p70S6K{sup Thr380} and ERK/GSK3{beta}{sup Thr390}/p70S6K{sup Thr421/Ser424} kinase signaling, which is involved in cell survival and cell death.

  15. Regulation XVI: GENERAL UNIVERSITY REGULATIONS

    E-Print Network [OSTI]

    Regulation XVI: GENERAL UNIVERSITY REGULATIONS APPLICATION AND INTERPRETATION 1. Unless stated otherwise, these and the following Regulations apply to students in all Faculties, including the International Faculty: General Regulations for First Degrees; General Regulations for Higher Degrees

  16. Regulating energy transfer of excited carriers and the case for...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulating energy transfer of excited carriers and the case for excitation-induced hydrogen dissociation on hydrogenated Regulating energy transfer of excited carriers and the case...

  17. From Saudi Arabia to Venezuela: Energy Resources, Market Factors & ConflictsEnergy Resources, Market Factors & Conflicts

    E-Print Network [OSTI]

    O'Donnell, Tom

    (Brazil, Russia, India and China) will end U.S. supremacy in the dollar based oil market? Lastly, weFrom Saudi Arabia to Venezuela: Energy Resources, Market Factors & ConflictsEnergy Resources, Market Factors & Conflicts Dr. Tom O'Donnell Friday, 12:00 2:48 PM Room 125, Mendenhall Laboratory

  18. BREEDING BIOLOGY AND NATURAL HISTORY OF THE SLATE-THROATED WHITESTART IN VENEZUELA

    E-Print Network [OSTI]

    Martin, Thomas E.

    BREEDING BIOLOGY AND NATURAL HISTORY OF THE SLATE-THROATED WHITESTART IN VENEZUELA ROMA N A. RUGGERA1,2,3 AND THOMAS E. MARTIN1 ABSTRACT.--We provide details on the breeding biology of the Slate 5 93) was the smallest recorded for the Slate-throated Whitestart. Incubation and nestling period

  19. Analysis of reservoir performance and forecasting for the eastern area of the C-2 Reservoir, Lake Maracaibo, Venezuela

    E-Print Network [OSTI]

    Urdaneta Anez, Jackeline C

    2001-01-01T23:59:59.000Z

    This research developed a numerical simulation based on the latest reservoir description to evaluate the feasibility of new infill wells to maximize the recovery specifically in the eastern region of the reservoir operated by Petroleos de Venezuela...

  20. Risk prevention and policy formulation : responding to the 1999 mud-floods catastrophe in El Litoral Central, Venezuela

    E-Print Network [OSTI]

    Parisca-Blanco, Sonia

    2005-01-01T23:59:59.000Z

    Fifteen days of constant and intense rainfall in Venezuela culminated on December 16 1999, in catastrophic landslides and flooding along 25 miles of the Vargas State coastal strip. This catastrophe ravaged the Caracas ...

  1. Misin Madres Del Barrio: A Bolivarian Social Program Recognizing Housework and Creating A Caring Economy in Venezuela

    E-Print Network [OSTI]

    Fischer-Hoffman, Cory

    2008-08-20T23:59:59.000Z

    , economic, social, and cultural history. The economic crisis stimulated by the debt crisis and neo-liberal reforms in Venezuela led to the recognition of unpaid housework as an esential 2 contribution to poverty reduction, especialy among the many... of Feminist-Marxism. These two camps diverge primarily in their strategies; one advocates for the socialization of housework and the other demands wages for housework. While these histories inform the struggle for the recognition for housework in Venezuela...

  2. Household energy use in urban Venezuela: Implications from surveys in Maracaibo, Valencia, Merida, and Barcelona-Puerto La Cruz

    SciTech Connect (OSTI)

    Figueroa, M.J.; Sathaye, J.

    1993-08-01T23:59:59.000Z

    This report identifies the most important results of a comparative analysis of household commercial energy use in Venezuelan urban cities. The use of modern fuels is widespread among all cities. Cooking consumes the largest share of urban household energy use. The survey documents no use of biomass and a negligible use of kerosene for cooking. LPG, natural gas, and kerosene are the main fuels available. LPG is the fuel choice of low-income households in all cities except Maracaibo, where 40% of all households use natural gas. Electricity consumption in Venezuela`s urban households is remarkably high compared with the levels used in households in comparable Latin American countries and in households of industrialized nations which confront harsher climatic conditions and, therefore, use electricity for water and space heating. The penetration of appliances in Venezuela`s urban households is very high. The appliances available on the market are inefficient, and there are inefficient patterns of energy use among the population. Climate conditions and the urban built form all play important roles in determining the high level of energy consumption in Venezuelan urban households. It is important to acknowledge the opportunities for introducing energy efficiency and conservation in Venezuela`s residential sector, particularly given current economic and financial constraints, which may hamper the future provision of energy services.

  3. Estradiol-Induced Object Memory Consolidation in Middle-Aged Female Mice Requires Dorsal Hippocampal Extracellular Signal-Regulated Kinase and Phosphatidylinositol 3-Kinase Activation

    E-Print Network [OSTI]

    Lewis, Michael C.

    We previously demonstrated that dorsal hippocampal extracellular signal-regulated kinase (ERK) activation is necessary for 17?[beta]-estradiol (E2[E subscript 2]) to enhance novel object recognition in young ovariectomized ...

  4. Carbachol ameliorates lipopolysaccharide-induced intestinal epithelial tight junction damage by down-regulating NF-{kappa}{beta} and myosin light-chain kinase pathways

    SciTech Connect (OSTI)

    Zhang, Ying [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China); Li, Jianguo, E-mail: 2010lijianguo@sina.cn [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)

    2012-11-16T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Carbachol reduced the lipopolysaccharide-induced intestinal barrier breakdown. Black-Right-Pointing-Pointer Carbachol ameliorated the lipopolysaccharide-induced ileal tight junction damage. Black-Right-Pointing-Pointer Carbachol prevented the LPS-induced NF-{kappa}{beta} and myosin light-chain kinase activation. Black-Right-Pointing-Pointer Carbachol exerted its beneficial effects in an {alpha}7 nicotinic receptor-dependent manner. -- Abstract: Carbachol is a cholinergic agonist that protects the intestines after trauma or burn injury. The present study determines the beneficial effects of carbachol and the mechanisms by which it ameliorates the lipopolysaccharide (LPS)-induced intestinal barrier breakdown. Rats were injected intraperitoneally with 10 mg/kg LPS. Results showed that the gut barrier permeability was reduced, the ultrastructural disruption of tight junctions (TJs) was prevented, the redistribution of zonula occludens-1 and claudin-2 proteins was partially reversed, and the nuclear factor-kappa beta (NF-{kappa}{beta}) and myosin light-chain kinase (MLCK) activation in the intestinal epithelium were suppressed after carbachol administration in LPS-exposed rats. Pretreatment with the {alpha}7 nicotinic acetylcholine receptor ({alpha}7nAchR) antagonist {alpha}-bungarotoxin blocked the protective action of carbachol. These results suggested that carbachol treatment can protect LPS-induced intestinal barrier dysfunction. Carbachol exerts its beneficial effect on the amelioration of the TJ damage by inhibiting the NF-{kappa}{beta} and MLCK pathways in an {alpha}7nAchR-dependent manner.

  5. {gamma}-aminobutyric acid{sub A} (GABA{sub A}) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of Methyl Tert-Butyl Ether (MTBE)-induced impairment of spatial memory

    SciTech Connect (OSTI)

    Zheng Gang; Zhang Wenbin [Department of Occupational and Environmental Health, School of Public Health and Military Preventive Medicine, Fourth Military Medical University, Xi'an 710032 (China); Zhang Yun [465 Hospital, Jilin Medical College, Jilin 132001 (China); Chen Yaoming; Liu Mingchao; Yao Ting; Yang Yanxia; Zhao Fang [Department of Occupational and Environmental Health, School of Public Health and Military Preventive Medicine, Fourth Military Medical University, Xi'an 710032 (China); Li Jingxia; Huang Chuanshu [Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987 (United States); Luo Wenjing [Department of Occupational and Environmental Health, School of Public Health and Military Preventive Medicine, Fourth Military Medical University, Xi'an 710032 (China)], E-mail: luowenj@fmmu.edu.cn; Chen Jingyuan [Department of Occupational and Environmental Health, School of Public Health and Military Preventive Medicine, Fourth Military Medical University, Xi'an 710032 (China)], E-mail: jy_chen@fmmu.edu.cn

    2009-04-15T23:59:59.000Z

    Experimental and occupational exposure to Methyl Tert-Butyl Ether (MTBE) has been reported to induce neurotoxicological and neurobehavioral effects, such as headache, nausea, dizziness, and disorientation, etc. However, the molecular mechanisms involved in MTBE-induced neurotoxicity are still not well understood. In the present study, we investigated the effects of MTBE on spatial memory and the expression and function of GABA{sub A} receptor in the hippocampus. Our results demonstrated that intraventricular injection of MTBE impaired the performance of the rats in a Morris water maze task, and significantly increased the expression of GABA{sub A} receptor {alpha}1 subunit in the hippocampus. The phosphorylation of ERK1/2 decreased after the MTBE injection. Furthermore, the decreased ability of learning and the reduction of phosphorylated ERK1/2 level of the MTBE-treated rats was partly reversed by bicuculline injected 30 min before the training. These results suggested that MTBE exposure could result in impaired spatial memory. GABA{sub A} receptor may play an important role in the MTBE-induced impairment of learning and memory by regulating the phosphorylation of ERK in the hippocampus.

  6. Fertility and rate of growth in a beef cattle herd in the 0rient of Venezuela

    E-Print Network [OSTI]

    Gonzalez Crespo, Justo Nicolas

    1978-01-01T23:59:59.000Z

    status upon pregnancy rate in Venezuela. They calculated adjusted means of lactating and nonlactating cows to be 54. 3~~ and 89. 2~ respect. ively. Such results have been re- ported by . , everal authors in Bolivia (Plasse et aL. , 1975 and Bauer et a... and Huertas, 1974, in Colombia and Bauer, 1973, in Bolivia). Thc negative effect of lactation upon ferti. lity seems to be related to the plane of nutrition (IViltbank et al. , 1961, 1964; Villar et al, 1975; Stonaker et al, 1975 and Bazan et al. , 1975...

  7. Regulation XVII: GENERAL REGULATIONS FOR FIRST DEGREES

    E-Print Network [OSTI]

    Regulation XVII: GENERAL REGULATIONS FOR FIRST DEGREES SCOPE OF THESE REGULATIONS4 1. These Regulations apply, subject to any different provision in the Regulations for a particular programme of study programme of study is designated as a non-modular programme, Regulation 14 and subsequent Regulations

  8. The Long-Run Relationship between Money, Nominal GDP, and the Price Level in Venezuela: 1950 to 1996

    E-Print Network [OSTI]

    Ahmad, Sajjad

    The Long-Run Relationship between Money, Nominal GDP, and the Price Level in Venezuela: 1950 that structural breaks may be important. Since the economy depends heavily on oil revenue, oil price shocks have whether a significant long-run relationship exists between money and nominal GDP and between money

  9. Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate

    E-Print Network [OSTI]

    Wriggers, Willy

    , Instituto Venezolano de Investigaciones Científicas, Apdo. 20632, Caracas 1020A, Venezuela 2 University

  10. Alternative Regulation (Vermont)

    Broader source: Energy.gov [DOE]

    Utility regulators, including the Public Service Board, have applied a new type of regulation, often called "alternative regulation" or "incentive regulation." There are many variants of this type...

  11. The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1{alpha} expression

    SciTech Connect (OSTI)

    Xu, Wei [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China) [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China); Department of cardiology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150081 (China); Guo, Ting; Zhang, Yan; Jiang, Xiaohong; Zhang, Yongxian [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)] [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China); Zen, Ke, E-mail: kzen@nju.edu.cn [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)] [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China); Yu, Bo, E-mail: yubodr@163.com [Department of cardiology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150081 (China)] [Department of cardiology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150081 (China); Zhang, Chen-Yu, E-mail: cyzhang@nju.edu.cn [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)] [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)

    2011-05-01T23:59:59.000Z

    Dexamethasone has been shown to inhibit vascular smooth muscle cell (VSMC) migration, which is required for preventing restenosis. However, the mechanism underlying effect of dexamethasone remains unknown. We have previously demonstrated that peroxisome proliferator-activated receptor gamma (PPAR{gamma}) coactivator-1 alpha (PGC-1{alpha}) can inhibit VSMC migration and proliferation. Here, we investigated the role of PGC-1{alpha} in dexamethasone-reduced VSMC migration and explored the possible mechanism. We first examined PGC-1{alpha} expression in cultured rat aortic VSMCs. The results revealed that incubation of VSMCs with dexamethasone could significantly elevate PGC-1{alpha} mRNA expression. In contrast, platelet-derived growth factor (PDGF) decreased PGC-1{alpha} expression while stimulating VSMC migration. Mechanistic study showed that suppression of PGC-1{alpha} by small interfering RNA strongly abrogated the inhibitory effect of dexamethasone on VSMC migration, whereas overexpression of PGC-1{alpha} had the opposite effect. Furthermore, an analysis of MAPK signal pathways showed that dexamethasone inhibited ERK and p38 MAPK phosphorylation in VSMCs. Overexpression of PGC-1{alpha} decreased both basal and PDGF-induced p38 MAPK phosphorylation, but it had no effect on ERK phosphorylation. Finally, inhibition of PPAR{gamma} activation by a PPAR{gamma} antagonist GW9662 abolished the suppressive effects of PGC-1{alpha} on p38 MAPK phosphorylation and VSMC migration. These effects of PGC-1{alpha} were enhanced by a PPAR{gamma} agonist troglitazone. Collectively, our data indicated for the first time that one of the anti-migrated mechanisms of dexamethasone is due to the induction of PGC-1{alpha} expression. PGC-1{alpha} suppresses PDGF-induced VSMC migration through PPAR{gamma} coactivation and, consequently, p38 MAPK inhibition.

  12. Government Regulation

    E-Print Network [OSTI]

    Ashford, Nicholas

    2005-01-01T23:59:59.000Z

    Abstract. Interest in the use of so-called voluntary approaches to supplement or replace formal environmental regulation is on the rise, both in Europe and in the United States. These approaches fall into two general ...

  13. Late Quaternary climate change from delta 13O records of multiple species of planktonic foraminifera: High-resolution records from the Anoxic Cariaco Basin, Venezuela

    E-Print Network [OSTI]

    Lin, Hui-Ling; Peterson, Larry C; Overpeck, Jonathan T; Trumbore, Susan E; Murray, David W

    1997-01-01T23:59:59.000Z

    252, 149-158. , 1954. waters of eastern Venezuela, Bol.C. Urey, Revised carbonate-water isotopic temperature scale,Atlantic-Mediterranean water H. -L. Lin, Institute of Marine

  14. Settlement patterns in the eastern coast of Maracaibo Lake, Venezuela : evaluation of existing settlements and model for a low income sector of El Menito new town

    E-Print Network [OSTI]

    Rodriguez Navas, Humberto Jos

    1983-01-01T23:59:59.000Z

    This thesis is divided in two parts; The First part is the physical analysis of residential settlements in the Eastern Coast of Maracaibo Lake, Venezuela. The work is based on surveys, evaluations and comparisons of four ...

  15. Sedimentological characterization of the C2' sequence, Block Lamar field, Maracaibo basin, Venezuela

    SciTech Connect (OSTI)

    Gustavo, F.B.; Gonzales, C. (INTEVEP, S.A., Caracas (Venezuela))

    1991-03-01T23:59:59.000Z

    Through the study of 2,109 ft of core from the Block V-Lamar field, central Maracaibo basin, Venezuela, the environments of deposition were established. The studied interval corresponds to the informal C2 sands of the Misoa Formation (Eocene). Seven different lithofacies were identified and later grouped into three sedimentary units deposited in a general, fluvial-dominated deltaic environment. The organization of the different lithofacies along with palynological data permitted the assignment of lower delta plain, upper delta plain, and, again, lower delta plain for the sedimentary units. The main subenvironments encountered include amalgamated distributary channel bars and related interdistributary bays. The distributary channels are thicker in the upper delta plain unit owing to a higher degree of stacking. Furthermore, sandstone thickness decreases in a southwest-northwest sense which indicates the direction of regression. This can be documented also with petrophysical characteristics of the reservoir reflected as a continuous decrease in porosity from 25 to 18%.

  16. Regulation 29: Other Regulations concerning the University site and buildings, Computing Regulations and Miscellaneous Administrative Regulations

    E-Print Network [OSTI]

    Sussex, University of

    Regulations and Miscellaneous Administrative Regulations 190 nuisance to occupants, except in designated (Vehicle Operators and Penalty Notices) Regulations; (iii) allow smoking in designated study bedroomsRegulation 29: Other Regulations concerning the University site and buildings, Computing

  17. Nuclear apoJ: A low dose radiation inducible regulator of cell death. Final report for period September 15, 1998 - September 14, 2001

    SciTech Connect (OSTI)

    Aronow, Bruce J.

    2002-04-19T23:59:59.000Z

    This project was based on preliminary data that was published by Dr. Boothman (Yang et al. 2000) which indicated a strong induction of apoJ gene expression, increased secretion of the protein, and accumulation of an apparently somewhat different form of the apoJ protein in the nucleus of MCF-7 breast carcinoma cells undergoing response to DNA damage. A clone expressing apoJ protein was isolated that was capable of interacting with Ku80, a component of the double strand break repair complex that is essential for the successful repair of rearranging immunoglobulin and T-cell receptor genes as evidenced by failure to produce mature B and T cells in the absence of Ku70. ApoJ clones isolated and characterized by Dr. Boothman bound strongly to a Ku-70 ''bait'' protein. Over-expression of these same clones in a cell line was capable of killing the cell. ApoJ is very strongly induced in many instances of programmed cell death and has been proposed repeatedly to play some sort of effector role in the process. Our principle hypothesis for this study was that the strong induction of the apoJ gene and the particular expression of a nuclear form of the protein was potentially a causal factor in the decision point made by the cell as it attempts to repair double-strand breakage based DNA damage. The hypothesis was that if sufficiently high damage occurred, it would be deleterious to maintain the cell's viability through continued DNA repair. One method to inhibit DNA repair might be by inhibiting proteins such as Ku-70 that are necessary for double-strand break repair. If apoJ does play a critical role in tipping the decision balance over to cell death, we reasoned that deficiency of apoJ would cause increased accumulation of cells with DNA damage and that this might decrease cell death in response to DNA damage and increase tumor occurrence rates. To test this hypothesis and its potential implications, we exposed wildtype and apoJ deficient animals that we constructed through gene targeting to increasing levels of ionizing radiation from a Cesium source. Data gathered under the support of this grant application initially indicated that apoJ deficient animals were more resistant to radiation, but as we accumulated more and more data points and covered a tighter exposure range, the genotype-based differences became insignificant. However, the possibility existed that because mortality based radiation-resistance could be attributable to mechanism for which nuclear apoJ was not rate determining, we maintained a very large of colony of apoJ knockout and wildtype animals in both the C57/B16 and Cv129 strain backgrounds that were exposed to sub-lethal levels of ionizing radiation to monitor for the occurrence of tumors. These animals were allowed to fully recover and age normally in either germ free or normal animal housing. Our results demonstrated no significant differences between wildtype and apoJ knockout animals over a period that extended up to 30 months for individual animals. We recorded similar weight gain, a relatively low mortality rate, and a similar mixture and rate of sarcoma and adenocarcinomas after surviving the initial ionizing radiation exposures. Thus we conclude that apoJ gene function, which was totally eliminated by our gene targeting, did not influence radiation sensitivity or serve as a tumor suppressor in response to DNA damage.

  18. A study of beef cattle marketing in Venezuela and the marketing margins between the farm and retail levels of prices

    E-Print Network [OSTI]

    Acosta, Sady Ines Borjas-Paez

    1975-01-01T23:59:59.000Z

    "Venezuela Beef Cattle Industry" comprises that sector of the agricultural economy which produces and sells cattle for beef and the agencies and firms involved in marketing of this product. Characteristics of Beef Cattle Production The peculiar ecosystem... savanna type veg- etation, mainly of the trachypogon species. The rest is covered by semi-decidious and gallery forest types includ ? . g b ) pp* ) d) t d ~b'' )b tt ) d) d savannas of PPaspalum fasciculatum" (Figure 3). Mean 0 0 annual temperature...

  19. Regulation XVIII: GENERAL REGULATIONS FOR HIGHER DEGREES,

    E-Print Network [OSTI]

    Regulation XVIII: GENERAL REGULATIONS FOR HIGHER DEGREES, POSTGRADUATE DIPLOMAS AND POSTGRADUATE CERTIFICATES SCOPE OF THESE REGULATIONS 1. These Regulations apply to the Degree of PhD in all Faculties in all Faculties Postgraduate Certificates in all Faculties. 2. These Regulations are subject

  20. Regulation 28: Library REGULATION 28: LIBRARY

    E-Print Network [OSTI]

    Sussex, University of

    Regulation 28: Library 180 REGULATION 28: LIBRARY The purpose of this Regulation is to safeguard the common interests of all Library users. All persons are admitted on the understanding that they have read and agreed to observe the Library Regulations. Breach of this Regulation could result in membership being

  1. E-Print Network 3.0 - apoptotic mechanisms induced Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cells induced... Ab with nave apoptotic T cells induced robust immunity. The infusion of large numbers of apoptotic cells has... Regulation of Immune ... Source: Iowa...

  2. Charge regulation circuit

    DOE Patents [OSTI]

    Ball, Don G. (Livermore, CA)

    1992-01-01T23:59:59.000Z

    A charge regulation circuit provides regulation of an unregulated voltage supply in the range of 0.01%. The charge regulation circuit is utilized in a preferred embodiment in providing regulated voltage for controlling the operation of a laser.

  3. Modelling regulations Completing an incomplete regulation

    E-Print Network [OSTI]

    van der Torre, Leon

    Objectives Modelling regulations Completing an incomplete regulation Examples Discussion Consistency and Completeness of Regulations Laurence Cholvy1 Stephanie Roussel1,2 1ONERA Centre de Toulouse 2ISAE, Toulouse NorMAS 2008, Luxembourg, July 2008 cholvy Consistency and Completeness of Regulations

  4. Diagenesis and reservoir characterization of the Block V-Lamar field, Maracaibo basin, Venezuela

    SciTech Connect (OSTI)

    Gonzales, C.; Gustavo, F. (INTEVEP, S.A., Caracas (Venezuela))

    1991-03-01T23:59:59.000Z

    The Block V-Lamar field, located in the central portion of Maracaibo basin, Venezuela, is the subject of this study. The sedimentary section corresponds to a section of the Misoa Formation of early to middle Eocene age. These sediments were deposited in the upper delta plain as stacked distributary channel bars and associated facies and consist of relatively clean sandstones, fine to medium grained, with a sublitharenitic to subarkosic composition. The clay mineral assemblage is mainly composed of kaolinite, followed by chlorite and subordinate amounts of discrete smectite, discrete illite, and mixed-layer illite/smectite with order stratification with 20-30% of expandable layers, all of diagenetic origin. Even though there is a remnant of primary porosity reduced by silica cement, most porosity is secondary as a result of cement, matrix, and unstable grain dissolution. The petrographic XRD and SEM data obtained allow the authors to define the following paragenetic sequences: (1) mechanical compaction; (2) silica cementation; (3) patchy calcite cementation; (4) dissolution of matrix, cements, feldspars, and rock fragments; (5) kaolinite precipitation at or near feldspar intragranular pores; (6) matrix recrystallization to chlorite; (7) precipitation of second generation of kaolinite; and (8) precipitation of smectite. The porosity and permeability distribution in the reservoirs is the result of the net effect of the different diagenetic events that include early diagenesis, medium to late diagenesis, and telodiagenesis, mainly in response to basinwide tectonism.

  5. Geological evaluation of San Diego Norte Pilot Project, Zuata area, Orinoco Oil Belt, Venezuela

    SciTech Connect (OSTI)

    De Rojas, I.

    1987-10-01T23:59:59.000Z

    The San Diego Norte Pilot Project consists of twelve inclined wells (7 producing wells 300 m (984 ft) apart, plus 5 observation wells) drilled from a cluster, to study the production and compaction behavior under steam soak (huff and puff) of the Tertiary heavy crude oil reservoirs of the Zuata area. This area is located within the Orinoco Heavy Oil belt of Venezuela. A geological model was needed as a base for the reservoir studies and to understand the geological setting. This model was constructed from extensive log information, seismic lines, well samples, and cores. The reservoir sands are friable with an average porosity of 34% and permeabilities ranging from 1 to 7 ..mu..m/sup 2/ (1 to 7 darcys). The sands were deposited in meander belts that stacked up forming multistory bodies. Point bars and channel fills account for 80-90% of the total sand. These sands are internally heterogeneous, sinuous and elongated, and larger than the 1 km/sup 2/ area covered by the project. The topmost two productive sands, which together average 22 m (72 ft), show the best porosities and permeabilities and are isolated by thick clays that make them suitable for selective steam injection. In the project, the oil has a density of about 1.0 g/cm/sup 3/ (10/sup 0/ API) and fills all the sands down to the oil-water contact. The depth of this contact is controlled by regional faults. Based on core compressibility tests, compaction is expected to be the principal production mechanism that could increase the expected primary recovery of 4 to 12% by huff and puff steam injection, leading to a possible recovery of 0.64 x 10/sup 6/ m/sup 3/ (4 million bbl) in six years with four cycles of steam injection. 16 figures, 2 tables.

  6. Studies on gene expression profiling in JB6 cells susceptible and resistant to tumor promoter induced neoplastic transformation and regulation of gene expression at the AP-1 DNA binding site

    E-Print Network [OSTI]

    Samuel, Shaija

    2005-11-01T23:59:59.000Z

    Gene expression underlies all important biological processes in a cell and mis-regulated gene expression plays a causal or contributory role in several diseases including cancers. Towards identifying molecular determinants ...

  7. California Energy Commission REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission REGULATIONS FINAL STATEMENT OF REASONS ENFORCEMENT PROCEDURES by Government Code section 11346.9(a) for the California Energy Commission (Energy Commission) regulations 399.30 (l) directs the Energy Commission to adopt regulations specifying procedures

  8. California Energy Commission REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission REGULATIONS NONRESIDENTIAL BUILDING ENERGY Disclosure Program California Code of Regulations Title 20. Public Utilities and Energy Division 2. State USE DISCLOSURE PROGRAM California Code of Regulations, Title 20, Division 2

  9. Forest Road Building Regulations

    Broader source: Energy.gov [DOE]

    The Wisconsin Department of Natural Resources has regulations for building a forest road, if development requires one. Regulations include zoning ordinances and permits for stream crossing, grading...

  10. Venezuela-MEM/USA-DOE Fossil Energy Report IV-11: Supporting technology for enhanced oil recovery - EOR thermal processes

    SciTech Connect (OSTI)

    Venezuela

    2000-04-06T23:59:59.000Z

    This report contains the results of efforts under the six tasks of the Tenth Amendment anti Extension of Annex IV, Enhanced Oil Recovery Thermal Processes of the Venezuela/USA Energy Agreement. This report is presented in sections (for each of the six Tasks) and each section contains one or more reports that were prepared to describe the results of the effort under each of the Tasks. A statement of each Task, taken from the Agreement Between Project Managers, is presented on the first page of each section. The Tasks are numbered 68 through 73. The first through tenth report on research performed under Annex IV Venezuela MEM/USA-DOE Fossil Energy Report Number IV-1, IV-2, IV-3, IV-4, IV-5, IV-6, IV-7, IV-8, IV-9, IV-10 contain the results of the first 67 Tasks. These reports are dated April 1983, August 1984, March 1986, July 1987, November 1988, December 1989, October 1991, February 1993, March 1995, and December 1997, respectively.

  11. UNIVERSITY STANDARDS AND REGULATIONS

    E-Print Network [OSTI]

    Royer, Dana

    20142015 UNIVERSITY STANDARDS AND REGULATIONS #12;Wesleyan University does not discriminate STANDARDS OF CONDUCT

  12. UNIVERSITY STANDARDS AND REGULATIONS

    E-Print Network [OSTI]

    Royer, Dana

    20132014 UNIVERSITY STANDARDS AND REGULATIONS #12;Wesleyan University does not discriminate STANDARDS OF CONDUCT

  13. Studies on gene expression profiling in JB6 cells susceptible and resistant to tumor promoter induced neoplastic transformation and regulation of gene expression at the AP-1 DNA binding site

    E-Print Network [OSTI]

    Samuel, Shaija

    2005-11-01T23:59:59.000Z

    and resistance to tumor promoter induced neoplastic transformation, we analyzed the gene expression profile differences among tumor promoter TPA treated and untreated mouse epidermal JB6 cells by means of cDNA microarray analyses. The expression patterns...

  14. Natural Gas Regulations (Kentucky)

    Broader source: Energy.gov [DOE]

    Kentucky Administrative Regulation title 805 promulgates the rules and regulations pertaining to natural gas production in Kentucky. In addition to KAR title 405, chapter 30, which pertains to any...

  15. Computer Use Regulation Introduction

    E-Print Network [OSTI]

    Liu, Paul

    Computer Use Regulation #12;Introduction · The following training materials will reference the contents of the Computer Use Regulations, but should not serve as a substitute for reading the actual responsibilities NCSU employees have under the regulations. · North Carolina State University's computer networks

  16. Emotion Regulation CONCEPTUAL FOUNDATIONS

    E-Print Network [OSTI]

    Gross, James J.

    CHAPTER 1 Emotion Regulation CONCEPTUAL FOUNDATIONS JAMES J. GROSS ROSS A. THOMPSON Standing, paper or plastic are made. Quotidian acts of emotion regulation such as this constitute one important- changes that require us to regulate how emotions are experienced and expressed. But what do people do

  17. 3 Library Regulations Definitions

    E-Print Network [OSTI]

    Mottram, Nigel

    3 Library Regulations Definitions In Regulation 3: 'Library' means the University Library as defined in Regulation 3.1; 'Library staff' means the staff of the University Library; 'Librarian' means the University Librarian and Head of Information Resources Directorate or nominee; `Library Committee' means

  18. Emotion Regulation and Vulnerability to Depression: Spontaneous Versus Instructed Use of Emotion Suppression and Reappraisal

    E-Print Network [OSTI]

    Gross, James J.

    Emotion Regulation and Vulnerability to Depression: Spontaneous Versus Instructed Use of Emotion vulnerability is related to difficulties with emotion regulation by comparing recovered-depressed and never of emotion regulation strategies. In the second phase, sad mood was induced using a film clip, and the degree

  19. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan ...........................................................................................................................................................................1 2. The need for regulating IDPs.................................................................................................................................................1 3. General principles of IDP regulation

  20. Load regulating expansion fixture

    DOE Patents [OSTI]

    Wagner, Lawrence M. (San Jose, CA); Strum, Michael J. (San Jose, CA)

    1998-01-01T23:59:59.000Z

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located therebetween. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components.

  1. Load regulating expansion fixture

    DOE Patents [OSTI]

    Wagner, L.M.; Strum, M.J.

    1998-12-15T23:59:59.000Z

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils is disclosed. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located therebetween. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components. 1 fig.

  2. CUTTING EDGE Cutting Edge: Essential Role of Hypoxia Inducible

    E-Print Network [OSTI]

    Nizet, Victor

    CUTTING EDGE IMMUNOLOGY THE OF JOURNAL Cutting Edge: Essential Role of Hypoxia Inducible Factor-1 raises the level of the transcriptional regu- lator hypoxia-inducible factor-1 (HIF-1 ) in macro- phages recently identified novel and essential roles of the transcriptional regulator hypox- ia-inducible factor

  3. Coal Mining Regulations (Kentucky)

    Broader source: Energy.gov [DOE]

    Kentucky Administrative Regulation Title 405 chapters 1, 2, 3, 5, 7, 8, 10, 12, 16, 18 and 20 establish the laws governing coal mining in the state.

  4. Regulation of natural monopolies

    E-Print Network [OSTI]

    Joskow, Paul L.

    2005-01-01T23:59:59.000Z

    This chapter provides a comprehensive overview of the theoretical and empirical literature on the regulation of natural monopolies. It covers alternative definitions of natural monopoly, regulatory goals, alternative ...

  5. Regulations of Wells (Florida)

    Broader source: Energy.gov [DOE]

    The Department of Environmental Protection regulates the construction, repair, and abandonment of wells, as well as the persons and businesses undertaking such practices. Governing boards of water...

  6. Tidal Wetlands Regulations (Connecticut)

    Broader source: Energy.gov [DOE]

    Most activities occurring in or near tidal wetlands are regulated, and this section contains information on such activities and required permit applications for proposed activities. Applications...

  7. Utility Regulation (Indiana)

    Broader source: Energy.gov [DOE]

    The Indiana Utility Regulatory Commission enforces regulations in this legislation that apply to all individuals, corporations, companies, and partnerships that may own, operate, manage, or control...

  8. alpha-related apoptosis-inducing ligand: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    c release channel MAC, mitochondrial apoptosis-induced channel CiteSeer Summary: Bcl-2 family proteins regulate apoptosis, in part, by controlling formation of the mitochondrial...

  9. Venezuela-MEM/USA-DOE Fossil Energy Report XIII-1, Supporting Technology for Enhanced Oil Recovery, Microbial EOR

    SciTech Connect (OSTI)

    Ziritt, Jose Luis

    1999-11-03T23:59:59.000Z

    The results from Annex XIII of the Cooperative Agreement between the United States Department of Energy (DOE) and the Ministry of Energy and Mines of the Republic of Venezuela (MEMV) have been documented and published with many researchers involved. Integrate comprehensive research programs in the area of Microbial Enhanced Oil Recovery (MEOR) ranged from feasibility laboratory studies to full-scale multi-well field pilots. The objective, to cooperate in a technical exchange of ideas and information was fully met throughout the life of the Annex. Information has been exchanged between the two countries through published reports and technical meetings between experts in both country's research communities. The meetings occurred every two years in locations coincident with the International MEOR conferences & workshops sponsored by DOE (June 1990, University of Oklahoma, September 1992, Brookhaven, September 1995, National Institute of Petroleum and Energy Research). Reports and publications produced during these years are listed in Appendix B. Several Annex managers have guided the exchange through the years. They included Luis Vierma, Jose Luis Zirritt, representing MEMV and E. B. Nuckols, Edith Allison, and Rhonda Lindsey, representing the U.S. DOE. Funding for this area of research remained steady for a few years but decreased in recent years. Because both countries have reduced research programs in this area, future exchanges on this topic will occur through ANNEX XV. Informal networks established between researchers through the years should continue to function between individuals in the two countries.

  10. Approaches to identifying reservoir heterogeneity and reserve growth opportunities from subsurface data: The Oficina Formation, Budare field, Venezuela

    SciTech Connect (OSTI)

    Hamilton, D.S.; Raeuchle, S.K.; Holtz, M.H. [Bureau of Economic Geology, Austin, TX (United States)] [and others

    1997-08-01T23:59:59.000Z

    We applied an integrated geologic, geophysical, and engineering approach devised to identify heterogeneities in the subsurface that might lead to reserve growth opportunities in our analysis of the Oficina Formation at Budare field, Venezuela. The approach involves 4 key steps: (1) Determine geologic reservoir architecture; (2) Investigate trends in reservoir fluid flow; (3) Integrate fluid flow trends with reservoir architecture; and (4) Estimate original oil-in-place, residual oil saturation, and remaining mobile oil, to identify opportunities for reserve growth. There are three main oil-producing reservoirs in the Oficina Formation that were deposited in a bed-load fluvial system, an incised valley-fill, and a barrier-strandplain system. Reservoir continuity is complex because, in addition to lateral facies variability, the major Oficina depositional systems were internally subdivided by high-frequency stratigraphic surfaces. These surfaces define times of intermittent lacustrine and marine flooding events that punctuated the fluvial and marginal marine sedimentation, respectively. Syn and post depositional faulting further disrupted reservoir continuity. Trends in fluid flow established from initial fluid levels, response to recompletion workovers, and pressure depletion data demonstrated barriers to lateral and vertical fluid flow caused by a combination of reservoir facies pinchout, flooding shale markers, and the faults. Considerable reserve growth potential exists at Budare field because the reservoir units are highly compartment by the depositional heterogeneity and structural complexity. Numerous reserve growth opportunities were identified in attics updip of existing production, in untapped or incompletely drained compartments, and in field extensions.

  11. REGULATION I: Responsibility for Creation and Amendment of Regulations

    E-Print Network [OSTI]

    REGULATION I: Responsibility for Creation and Amendment of Regulations 1. In accordance with Article 14 of the Charter, the Council shall have the power to make, amend or repeal Regulations. 2 of the Regulations and the delegation of such power pursuant to Regulation II (7.2) by the Council to Senate

  12. Workshop in Regulation &

    E-Print Network [OSTI]

    Lin, Xiaodong

    Smart Grid and Regulatory Issues April 1, 2011 K&L Gates LLP, 1601 K Street, NW, Washington, DC Viable Regulation." Victor Glass, NECA, Comments January 14, 2011 Smart Grid and Regulatory Issues Location: Rutgers, The Brattle Group, "Smart Grid/Smart Regulation" John Caldwell, EEI, "Economic Efficiency and the Smart Grid

  13. Post-translational regulation enables robust p53 regulation

    E-Print Network [OSTI]

    Shin, Yong-Jun; Chen, Kai-Yuan; Sayed, Ali H; Hencey, Brandon; Shen, Xiling

    2013-01-01T23:59:59.000Z

    PS, Elowitz MB: Gene regulation at the single-cell level.JC, Song B, Kudo K, Chu E: Regulation of p53 expression inChen L, Li Z, et al: Regulation of MDM2 E3 ligase activity

  14. Army Regulation 690600 Civilian Personnel

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 690600 Civilian Personnel Equal Employment Opportunity Discrimination Complaints Civilian Personnel Equal Employment Opportunity Discrimination Complaints *Army Regulation 690600 Effective 9 March 2004 History. This publication is a major revision. Summary. This regulation establishes

  15. California Energy Commission PROPOSED REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission PROPOSED REGULATIONS ENFORCEMENT PROCEDURES on concepts for the proposed regulations. Energy Commission staff held additional public workshops on March regulations. Throughout this process, the Energy Commission received and considered comments from

  16. California Energy Commission PROPOSED REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission PROPOSED REGULATIONS MARCH 2012 CEC-400-2010-004-SD3 NONRESIDENTIAL BUILDING ENERGY USE DISCLOSURE PROGRAM Proposed Regulations Title 20, Division 2, Chapter 4 PREFACE The California Energy Commission is releasing proposed regulations for implementing Assembly

  17. Dam Safety Regulation (Mississippi)

    Broader source: Energy.gov [DOE]

    The purpose of the Dam Safety Regulation is to ensure that all dams constructed in the state of Mississippi are permitted and thus do not potentially harm wildlife, water supplies and property. ...

  18. Dam Safety Regulations (Connecticut)

    Broader source: Energy.gov [DOE]

    All dams, except those owned by the U.S., are under the jurisdiction of these regulations. These dams will be classified by hazard rating, and may be subject to periodic inspections. The...

  19. Of Refrigerators & Regulations

    Broader source: Energy.gov [DOE]

    Editor's Note: This entry has been cross-posted from The White House Blog. The President took a moment during his speech to put the debate over regulation in a different perspective.

  20. Sulfur Dioxide Regulations (Ohio)

    Broader source: Energy.gov [DOE]

    This chapter of the law establishes that the Ohio Environmental Protection Agency provides sulfur dioxide emission limits for every county, as well as regulations for the emission, monitoring and...

  1. Underground Storage Tank Regulations

    Broader source: Energy.gov [DOE]

    The Underground Storage Tank Regulations is relevant to all energy projects that will require the use and building of pipelines, underground storage of any sorts, and/or electrical equipment. The...

  2. Cenozoic oblique collision of South American and Caribbean plates: New evidence in the Coastal Cordillera of Venezuela and Trinidad

    SciTech Connect (OSTI)

    Speed, R.C. (Northwestern Univ., Evanston, IL (United States)); Russo, R.M. (Carnegie Institute of Washington (United States)); Foland, K.A. (Ohio State Univ., Columbus (United States))

    1993-02-01T23:59:59.000Z

    The hinterland of the Caribbean Mts. orogen in Trinidad and Venezuela contains schist and gneiss whole protoliths are wholly or partly of continental provenance. The hinterland lies between the foreland thrust belt and terranes. The terranes are alien to continental South America (SA) and may have proto-Caribbean or Caribbean plate origins. The hinterland rocks were widely thought to come from sediments and granitoids of Mesozoic protolithic ages and to be of Cretaceous metamorphic age. Such rocks are now know to be of at least two or more types, as follows: (1) low grade, protoliths of pre-Mesozoic basement and shelfal cover of uncertain age range, inboard locus, Oligocene to mid-Miocene metamorphic ages younging eastward (Caracas, Paria, and Northern Range belts), and (2) higher grade including high P/T, varies protoliths of uncertain age range, Cretaceous and ( )early Paleogene metamorphic ages (Tacagua, Araya, Margarita). The geometry, protoliths, structures, and metamorphic ages of type 1 parautochthoneity and an origin as a thickened wedge of crust-cored passive margin cover. The wedge grew by accretion between about 35 and 20 Ma during oblique transport toward the foreland. The diachroneity of metamorphism implies, as does the timing of foreland deformation, that the wedge evolved in a right-oblique collision between northern SA and terranes moving wholly or partly with the Caribbean plate since the Eocene. Type 2 rocks probably came with the terranes and are products of convergent zone tectonics, either in the proto-Caribbean plate. The hinterland boundaries are brittle thrusts that are out of sequence and imply progressive contraction from mid-Cenozoic to the present.

  3. Regulation 2: Student Discipline REGULATION 2: STUDENT DISCIPLINE

    E-Print Network [OSTI]

    Sussex, University of

    Regulation 2: Student Discipline 6 REGULATION 2: STUDENT DISCIPLINE 1. Definitions In this Regulation: The University means the University of Sussex. Council means Council of the University. Senate to the regulations of the affiliated institution, and excluding students in attendance at the Brighton and Sussex

  4. SB 4 Well Stimulation Treatment Regulations Text of Proposed Regulations

    E-Print Network [OSTI]

    surveys; routine activities that do not affect the integrity of the well or the formation; the removal SB 4 Well Stimulation Treatment Regulations Text of Proposed Regulations Page 1 of 13 SB 4 WELL STIMULATION TREATMENT REGULATIONS TEXT OF PROPOSED REGULATIONS Added text is shown in underline

  5. The inverted Lamar sub-basin, Lake Maracaibo, Venezuela: Tectonic evolution and hydrocarbon habitat

    SciTech Connect (OSTI)

    Arminio, J.F. [Maraven S.A., Caracas (Venezuela); Growcott, A.M. [Intera Information Technologies, Henley-Upon-Thames, Oxfordshire, (United Kingdom)

    1996-08-01T23:59:59.000Z

    In the central part of the Maracaibo basin, integration of recently acquired 3-D seismic and existing geological data has led to the definition of the Lamar sub-basin as an array of partially inverted half grabens which formed during Late Cretaceous and Early to Middle Eocene times as a result of transtensional episodes along older rift structures. This integration exercise has also led to the addition of new reserves in a mature oil province. Six major tectonic phases can be distinguished: (a.) Extension of the existing Paleozoic substrate during Jurassic rifting; (b.) Passive margin tectonic quiescence from Middle to Late Cretaceous; (c.) Paleocene uplift and erosion; (d.) Eocene transtension along reactivated Jurassic lineaments; (e.) Late Eocene to Mid Miocene inversion; (f.) Late Miocene to Recent post inversion and regional tilt. Distinctive tectonically induced unconformities within the Eocene sedimentary fill imply tectonic overprint rather than eustatic controls. The Eocene extensional structures were inverted in a selective manner depending upon their orientation relative to the dominant compressional vector. This in turn resulted in significant hydrocarbon re-migration and a rather complex fluid distribution throughout the area.

  6. Price regulation for waste hauling franchises in California: an examination of how regulators regulate pricing and the effects of competition on regulated markets

    E-Print Network [OSTI]

    Seltzer, Steven A.

    2011-01-01T23:59:59.000Z

    and popular recent incentive regulation alternatives,if costs increase. Incentive regulation most particularly

  7. MINIREVIEW / MINISYNTHE` SE The role of chromatin structure in regulating

    E-Print Network [OSTI]

    Krebs, Jocelyn E.

    within many stress-induced promoters, such as stress re- sponse elements and heat shock elements, allow. Key words: chromatin, transcription, stress response, heat shock. Resume : Toutes les cellules, quMINIREVIEW / MINISYNTHE` SE The role of chromatin structure in regulating stress

  8. Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

    E-Print Network [OSTI]

    Dinner, Aaron

    analyses have led to the formulation of a ``kinetic control'' model for the regulation of B cell-f results support a model of ``kinetic control'' in which signaling-induced dynamics of IRF4 in activated BImmunity Article Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical

  9. The availability of purine nucleotides regulates natural competence by controlling translation of the competence

    E-Print Network [OSTI]

    Redfield, Rosemary J. "Rosie"

    The availability of purine nucleotides regulates natural competence by controlling translation that the depletion of purine nucleotides under competence- inducing conditions activates the CRP-dependent competence-specific regulator Sxy. Depletion of extra- or intra-cellular purine nucleotides activates Sxy translation, while

  10. Workshop in Regulation &

    E-Print Network [OSTI]

    Lin, Xiaodong

    Consulting "Pipeline - A Reincarnation of Stranded Costs" Sean K. Collins, Federal Energy Regulatory Industries November 16, 2012 Rutgers Business School, 1 Washington Park Newark, NJ Regulation, Smart Grid and Reliability January 11, 2013 Rutgers Business School, 1 Washington Park Newark, NJ Generation and Demand

  11. Design of Optimal Regulators

    E-Print Network [OSTI]

    Alexander Bolonkin; Robert Sierakowski

    2007-01-19T23:59:59.000Z

    Current research suggests the use of a liner quadratic performance index for optimal control of regulators in various applications. Some examples include correcting the trajectory of rocket and air vehicles, vibration suppression of flexible structures, and airplane stability. In all these cases, the focus is in suppressing/decreasing system deviations rapidly. However, if one compares the Linear Quadratic Regulator (LQR) solution with optimal solutions (minimum time), it is seen that the LQR solution is less than optimal in some cases indeed (3-6) times that obtained using a minimum time solution. Moreover, the LQR solution is sometimes unacceptable in practice due to the fact that values of control extend beyond admissible limits and thus the designer must choose coefficients in the linear quadratic form, which are unknown. The authors suggest methods which allow finding a quasi-optimal LQR solution with bounded control which is closed to the minimum time solution. They also remand the process of the minimum time decision. Keywords: Optimal regulator, minimum time controller, Linear Quadratic Regulator (LQR). -- This paper is declared a work of the U.S. Government and not subject to copyright protection in the USA. The manuscript is accepted as paper AIAA-2003-6638 by 2nd AIAA Unmanned Unlimited Systems, Technologies, and Operations-Aerospace, Land, and See Conference and Workshop - Exhibit, San Diego, California, USA, 15-18 Sep. 2003.

  12. Regulation 8: Responsibility for Creation and Amendment of Regulations: REGULATION 8: RESPONSIBILITY FOR CREATION AND AMENDMENT OF

    E-Print Network [OSTI]

    Sussex, University of

    Regulation 8: Responsibility for Creation and Amendment of Regulations: 36 REGULATION 8: RESPONSIBILITY FOR CREATION AND AMENDMENT OF REGULATIONS This Regulation may only be amended at a meeting and revoke Regulations. Regulations may be created, amended and revoked at any meeting of Council. 2

  13. Oleic AcidDependent Modulation of NITRIC OXIDE ASSOCIATED1 Protein Levels Regulates Nitric

    E-Print Network [OSTI]

    Kachroo, Pradeep

    of AgricultureAgricultural Research Service, Washington State University, Prosser, Washington 99350 acid, which induces anti-inflammatory effects (Denys et al., 2001). FAs also serve as alarm molecules also regulate salt, drought, and heavy metal tolerance as well as wounding-induced responses

  14. Interrelationship of Program Regulations and Financial Assistance Regulations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1980-04-24T23:59:59.000Z

    The purpose of this Order is to set forth the interrelationship between all program regulations which will result in assistance awards (Program Regulations) and the Department of Energy Assistance Regulations (DOE-AR, 10 CRF Part 600), including procedures for exceptions, deviations or waivers.

  15. Surface Coal Mining Regulations (Mississippi)

    Broader source: Energy.gov [DOE]

    The Surface Coal Mining Regulations are a combination of permitting requirements and environmental regulations that limit how, where and when coal can be mined. It protects lands that are under...

  16. Corporate governance and banking regulation

    E-Print Network [OSTI]

    Alexander, Kern

    The globalisation of banking markets has raised important issues regarding corporate governance regulation for banking institutions. This research paper addresses some of the major issues of corporate governance as it relates to banking regulation...

  17. Hazardous Waste Management Regulations (Mississippi)

    Broader source: Energy.gov [DOE]

    The Hazardous Waste Management Regulations follow the EPA's definitions and guidelines for the most part, which are listed in 40 CFR parts 260-282. In addition to these federal regulations the...

  18. California Energy Commission PROPOSED REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission PROPOSED REGULATIONS INITIAL STATEMENT OF REASONS FOR ENFORCEMENT CEC3002013004 CALIFORNIA ENERGY COMMISSION Edmund G. Brown, Jr., Governor #12;#12;1 INITIAL STATEMENT OF REASONS PROPOSED REGULATIONS ENFORCEMENT PROCEDURES FOR THE RENEWABLES PORTFOLIO STANDARD

  19. Land Use Regulation with Durable Capital

    E-Print Network [OSTI]

    Quigley, John M.; Swoboda, Aaron

    2009-01-01T23:59:59.000Z

    Manhattan so expensive? Regulation and the rise of housingmotive for restrictive regulation by local home owners.the impacts of these regulations vary across owner- occupied

  20. Prenatal maternal stress programs infant stress regulation.

    E-Print Network [OSTI]

    Davis, Elysia Poggi; Glynn, Laura M; Waffarn, Feizal; Sandman, Curt A

    2011-01-01T23:59:59.000Z

    Programs Infant Stress Regulation Elysia Poggi Davis, PhDglucocorticoids disrupts the regulation of physiological andstress alters circadian regulation and laboratory levels of

  1. Price regulation for waste hauling franchises in California: an examination of how regulators regulate pricing and the effects of competition on regulated markets

    E-Print Network [OSTI]

    Seltzer, Steven A.

    2011-01-01T23:59:59.000Z

    Thomadakis, Stavros. Price Regulation Under Uncertainty inin the Theory of Regulation. Handbook of IndustrialMark and David Sappington. Regulation, Competition and

  2. Essays on the politics of regulation

    E-Print Network [OSTI]

    Weymouth, Stephen

    2010-01-01T23:59:59.000Z

    F. , 2002: Does entry regulation hinder job creation? evi-Macroeconomic effects of regulation and dereg- ulation inand Shleifer, A. , 2004: The regulation of labor. Quarterly

  3. Nanotechnology Regulation: A Study in Claims Making

    E-Print Network [OSTI]

    Malloy, Timothy F.

    2011-01-01T23:59:59.000Z

    Nanomaterials: Principles, Regulation, and Renegotiating theJoseph Rees, Industry Self-Regulation: An InstitutionalDarren Sinclair, Self-Regulation Versus Command and Control?

  4. Regulation, Unemployment, and Cost-Benefit Analysis

    E-Print Network [OSTI]

    Posner, Eric; Masur, Jonathan S.

    2011-01-01T23:59:59.000Z

    and Eric A. Posner, Regulation, Unemployment, and Cost-effects of environmental regulations for other industries.PaperCollection. Regulation, Unemployment, and Cost-

  5. Energy Efficiency in Regulated and Deregulated Markets

    E-Print Network [OSTI]

    Rotenberg, Edan

    2005-01-01T23:59:59.000Z

    establishing what energy efficiency, regulation, and der-policy justifications for energy efficiency regulations. Thesector. ENERGY EFFICIENCY UNDER REGULATION This section

  6. Regulation of Meiotic Recombination

    SciTech Connect (OSTI)

    Gregory p. Copenhaver

    2011-11-09T23:59:59.000Z

    Meiotic recombination results in the heritable rearrangement of DNA, primarily through reciprocal exchange between homologous chromosome or gene conversion. In plants these events are critical for ensuring proper chromosome segregation, facilitating DNA repair and providing a basis for genetic diversity. Understanding this fundamental biological mechanism will directly facilitate trait mapping, conventional plant breeding, and development of genetic engineering techniques that will help support the responsible production and conversion of renewable resources for fuels, chemicals, and the conservation of energy (1-3). Substantial progress has been made in understanding the basal recombination machinery, much of which is conserved in organisms as diverse as yeast, plants and mammals (4, 5). Significantly less is known about the factors that regulate how often and where that basal machinery acts on higher eukaryotic chromosomes. One important mechanism for regulating the frequency and distribution of meiotic recombination is crossover interference - or the ability of one recombination event to influence nearby events. The MUS81 gene is thought to play an important role in regulating the influence of interference on crossing over. The immediate goals of this project are to use reverse genetics to identify mutants in two putative MUS81 homologs in the model plant Arabidopsis thaliana, characterize those mutants and initiate a novel forward genetic screen for additional regulators of meiotic recombination. The long-term goal of the project is to understand how meiotic recombination is regulated in higher eukaryotes with an emphasis on the molecular basis of crossover interference. The ability to monitor recombination in all four meiotic products (tetrad analysis) has been a powerful tool in the arsenal of yeast geneticists. Previously, the qrt mutant of Arabidopsis, which causes the four pollen products of male meiosis to remain attached, was developed as a facile system for assaying recombination using tetrad analysis in a higher eukaryotic system (6). This system enabled the measurement of the frequency and distribution of recombination events at a genome wide level in wild type Arabidopsis (7), construction of genetic linkage maps which include positions for each centromere (8), and modeling of the strength and pattern of interference (9). This proposal extends the use of tetrad analysis in Arabidopsis by using it as the basis for assessing the phenotypes of mutants in genes important for recombination and the regulation of crossover interference and performing a novel genetic screen. In addition to broadening our knowledge of a classic genetic problem - the regulation of recombination by crossover interference - this proposal also provides broader impact by: generating pedagogical tools for use in hands-on classroom experience with genetics, building interdisciplinary collegial partnerships, and creating a platform for participation by junior scientists from underrepresented groups. There are three specific aims: (1) Isolate mutants in Arabidopsis MUS81 homologs using T-DNA and TILLING (2) Characterize recombination levels and interference in mus81 mutants (3) Execute a novel genetic screen, based on tetrad analysis, for genes that regulate meiotic recombination

  7. Cogeneration and its regulations

    SciTech Connect (OSTI)

    Casten, T.R.; Ross, H.E.

    1981-03-26T23:59:59.000Z

    In the near term, regulators, utility managements, and legislators will grapple with numerous issues surrounding the development of cogeneration projects as sources of electric power. The Federal Energy Regulatory Commission predicts that 12,000 MW of new cogeneration plants will be constructed during the 1980s, and all 50 states are in the process of implementing new regulations pursuant to the Public Utility Regulatory Policies Act. The US utility system's overall fuel efficiency of 29% offers rich opportunities to conserve fuel, reduce costs, and decrease pollution via cogeneration. Policymakers should stop viewing utilities simply as efficiency tax collectors on the one hand and opponents of innovation on the other. In addition to mothballing inefficient central utility stations, the US must rapidly deploy district heating with cogenerated heat; policymakers should look beyond the obsolete stream systems and encourage development of the high-temperature hot-water systems so successful in Europe.

  8. Temperature controlled high voltage regulator

    DOE Patents [OSTI]

    Chiaro, Jr., Peter J. (Clinton, TN); Schulze, Gerald K. (Knoxville, TN)

    2004-04-20T23:59:59.000Z

    A temperature controlled high voltage regulator for automatically adjusting the high voltage applied to a radiation detector is described. The regulator is a solid state device that is independent of the attached radiation detector, enabling the regulator to be used by various models of radiation detectors, such as gas flow proportional radiation detectors.

  9. Emotion Regulation JAMES J. GROSS

    E-Print Network [OSTI]

    Gross, James J.

    CHAPTER 31 Emotion Regulation JAMES J. GROSS Have you ever gotten so angry that you've done). Although the topic of emotion regulation is a relatively late addition to the field of emotion, a concern with emotion regulation is anything but new. Emotion regu lation has been a focus in the study of psycho

  10. Army Regulation 2001 Environmental Quality

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 2001 Environmental Quality Environmental Protection and Enhancement Headquarters Environmental Protection and Enhancement *Army Regulation 2001 Effective 27 December 2007 History in the summary of change. Summary. This regulation covers envi- ronmental protection and enhancement and provides

  11. REGULATION AND DISTRUST Philippe AGHION

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    REGULATION AND DISTRUST Philippe AGHION Yann ALGAN Pierre CAHUC Andrei SHLEIFER January 2009 Cahier://www.enseignement.polytechnique.fr/economie/ mailto:chantal.poujouly@polytechnique.edu hal-00396268,version1-17Jun2009 #12;REGULATION AND DISTRUST1: In a cross-section of countries, government regulation is strongly negatively correlated with social capital

  12. Improving CS regulations.

    SciTech Connect (OSTI)

    Nesse, R.J.; Scheer, R.M.; Marasco, A.L.; Furey, R.

    1980-10-01T23:59:59.000Z

    President Carter issued Executive Order 12044 (3/28/78) that required all Federal agencies to distinguish between significant and insignificant regulations, and to determine whether a regulation will result in major impacts. This study gathered information on the impact of the order and the guidelines on the Office of Conservation and Solar Energy (CS) regulatory practices, investigated problems encountered by the CS staff when implementing the order and guidelines, and recommended solutions to resolve these problems. Major tasks accomplished and discussed are: (1) legislation, Executive Orders, and DOE Memoranda concerning Federal administrative procedures relevant to the development and analysis of regulations within CS reviewed; (2) relevant DOE Orders and Memoranda analyzed and key DOE and CS staff interviewed in order to accurately describe the current CS regulatory process; (3) DOE staff from the Office of the General Counsel, the Office of Policy and Evaluation, the Office of the Environment, and the Office of the Secretary interviewed to explore issues and problems encountered with current CS regulatory practices; (4) the regulatory processes at five other Federal agencies reviewed in order to see how other agencies have approached the regulatory process, dealt with specific regulatory problems, and responded to the Executive Order; and (5) based on the results of the preceding four tasks, recommendations for potential solutions to the CS regulatory problems developed. (MCW)

  13. certification, compliance and enforcement regulations for Commercial...

    Office of Environmental Management (EM)

    certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) certification, compliance and enforcement regulations for Commercial...

  14. Self-regulating valve

    DOE Patents [OSTI]

    Humphreys, D.A.

    1982-07-20T23:59:59.000Z

    A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.

  15. Nebraska Air Quality Regulations (Nebraska)

    Broader source: Energy.gov [DOE]

    These regulations, promulgated by the Department of Environmental Quality, contain provisions pertaining to ambient air quality standards, pollution source operating permits, emissions reporting,...

  16. Regulations For Gas Companies (Tennessee)

    Broader source: Energy.gov [DOE]

    The Regulations for Gas Companies, implemented by the Tennessee Regulatory Authority (Authority) outline the standards for metering, distribution and electricity generation for utilities using gas....

  17. Environmental Regulation, Globalization, and Innovation

    E-Print Network [OSTI]

    Ashford, Nicholas

    2009-01-01T23:59:59.000Z

    This essay explores the complex relationship between environmental regulation, innovation, and sustainable development within the context of an increasingly globalizing economy. It will be argued that industrial policy, ...

  18. Nebraska Hazardous Waste Regulations (Nebraska)

    Broader source: Energy.gov [DOE]

    These regulations, promulgated by the Department of Environmental Quality, contain provisions pertaining to hazardous waste management, waste standards, permitting requirements, and land disposal...

  19. The next restructuring: Environmental regulation

    SciTech Connect (OSTI)

    Ellerman, A.D. (Massachusetts Inst. of Tech., Cambridge, MA (United States). Center for Energy and Environmental Policy Research)

    1999-01-01T23:59:59.000Z

    From oil, to natural gas, and now electricity, the regulation of energy markets has been successively restructured to allow greater scope to market forces. The likely next domain for restructuring, environmental regulation, may seem far-fetched now, but it is no more so than the restructuring of electric utility regulation would have seemed to be twenty years ago. The grand experiment with emissions trading under the US acid rain program has set a propitious example by showing that markets in environmental goods can be constructed and that the explicit recognition of property rights in the use of the environment is compatible with effective and non-intrusive environmental regulation.

  20. Underground Injection Control Regulations (Kansas)

    Broader source: Energy.gov [DOE]

    This article prohibits injection of hazardous or radioactive wastes into or above an underground source of drinking water, establishes permit conditions and states regulations for design,...

  1. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms,...

  2. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wednesday, 29 August 2007 00:00 The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms,...

  3. REGULATION POLITIQUE ET REGULATION D'USAGE DANS LE TEMPS DE TRAVAIL1

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    1 REGULATION POLITIQUE ET REGULATION D'USAGE DANS LE TEMPS DE TRAVAIL1 : par G. de Terssac, J REGULATION AND REGULATION OF USE OVER WORKING TIME In this paper we discuss social regulations as defined by Reynaud (1999). These regulations, in our case (working)-time regulations, are multiple. Their combination

  4. TABLE OF CONTENTS CALIFORNIA CODE OF REGULATIONS ADMINISTRATIVE REGULATIONS

    E-Print Network [OSTI]

    #12;#12;i TABLE OF CONTENTS CALIFORNIA CODE OF REGULATIONS ADMINISTRATIVE REGULATIONS Section 10............................................. Admin-7 Section 10-106 -- Locally Adopted Energy Standards Product U-Values, Solar Heat Gain Coefficient, and Air Leakage....... Admin-12 Section 10-112 -- Criteria

  5. Advanced Workshop in Regulation and

    E-Print Network [OSTI]

    Lin, Xiaodong

    Advanced Workshop in Regulation and Competition 2011-2012 Conflicting Technological and Competitive Forces in Regulated Industries January 13, 2012 Smart Grid and Rates Location: Rutgers Business School 1:40pm "Smart Grid in Maryland" Kurt Strunk, NERA Economic Consulting, 1:40pm-2:05pm "Gas Pipeline Rates

  6. Dysregulation of nuclear factor kappa B activity and osteopontin expression in oxidant-induced atherogenesis

    E-Print Network [OSTI]

    Williams, Edward Spencer

    2004-09-30T23:59:59.000Z

    NF-?B activity is critical in the regulation of atherosclerotic vascular smooth muscle cell (vSMC) phenotypes induced following oxidative injury by allylamine. The present studies were designed to detail dysregulation of ...

  7. Competitive niche: Way of population regulation

    E-Print Network [OSTI]

    Meszna, Gza

    1 / 27 Competitive niche: Way of population regulation Geza Meszena1, Andras Szilagyi1, Kalle of coexistence Theory Regulating loop Results Examples Spatial segregation Functional & spatial segregation Regulating loop y Results Examples Conclusions 7 / 27 #12;Regulating loop Introduction Theory y Regulating

  8. NOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005

    E-Print Network [OSTI]

    Wu, Shin-Tson

    , Deputy Director of Florida Solar Energy Center COMMENTS CONCERNING THE PROPOSED REGULATION AMENDMENTNOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005 REGULATION TITLE: REGULATION NO OF REGULATION AMENDMENT: This regulation is revised significantly to reflect updated naming conventions

  9. CO{sub 2} emissions from developing countries: Better understanding the role of Energy in the long term. Volume 2, Argentina, Brazil, Mexico, and Venezuela

    SciTech Connect (OSTI)

    Ketoff, A.; Sathaye, J.; Goldman, N. [eds.

    1991-07-01T23:59:59.000Z

    Recent years have witnessed a growing recognition of the link between emissions of carbon dioxide (CO{sub 2}) and changes in the global climate. Of all anthropogenic activities, energy production and use generate the single largest portion of these greenhouse gases. Although developing countries currently account for a small share of global carbon emissions, their contribution is increasing rapidly. Due to the rapid expansion of energy demand in these nations, the developing world`s share in global modern energy use rose from 16 to 27 percent between 1970 and 1990. If the growth rates observed over the past 20 years persist energy demand in developing will surpass that in the countries of the Organization for Economic Cooperation and Development (OECD) early in the 21st century. The study seeks to examine the forces that galvanize the growth of energy use and carbon emissions, to assess the likely future levels of energy and CO{sub 2} in selected developing nations and to identify opportunities for restraining this growth. The purpose of this report is to provide the quantitative information needed to develop effective policy options, not to identify the options themselves. These individual studies were conducted fro Argentina, Brazil, Mexico and Venezuela in Latin America.

  10. Multidrug resistant protein-three gene regulation

    E-Print Network [OSTI]

    Mahaffey, Christopher M.

    2010-01-01T23:59:59.000Z

    H. R. ;Mulcahy, R. T. Up-regulation of the human gamma-H. R. ; Mulcahy, R. T. Regulation of gamma- glutamylcysteine19] Gerk, P. M. ; Vore, M. Regulation of expression of the

  11. MANEUVER REGULATION, TRANSVERSE FEEDBACK LINEARIZATION, AND ZERO

    E-Print Network [OSTI]

    Maggiore, Manfredi

    MANEUVER REGULATION, TRANSVERSE FEEDBACK LINEARIZATION, AND ZERO DYNAMICS Chris Nielsen,1 Manfredi focus is on output maneuver regulation where stabilizing transverse dynamics is a key requirement. Keywords: Maneuver regulation, path following, feedback linearization, zero dynamics, non-square systems

  12. Army Regulation 2550 Information Management: Records

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 2550 Information Management: Records Management Preparing and Managing Information Management: Records Management Preparing and Managing Correspondence *Army Regulation 25. This regulation on the prepa- ration and management of Army corre- spondence has been revised. This revision

  13. Post regulation circuit with energy storage

    DOE Patents [OSTI]

    Ball, Don G. (Livermore, CA); Birx, Daniel L. (Oakley, CA); Cook, Edward G. (Livermore, CA)

    1992-01-01T23:59:59.000Z

    A charge regulation circuit provides regulation of an unregulated voltage supply and provides energy storage. The charge regulation circuit according to the present invention provides energy storage without unnecessary dissipation of energy through a resistor as in prior art approaches.

  14. Regulating competitive markets: How to proceed?

    SciTech Connect (OSTI)

    Santa, D.F. Jr.

    1995-12-31T23:59:59.000Z

    This paper describes the regulation of electricity and natural gas market. The prerequisites for market-based rates, regulating potentially competitive markets, regulating services where market power exists, and electronic communications and trading systems are discussed.

  15. The Nuclear Installations (Dangerous Occurrences) Regulations 1965

    E-Print Network [OSTI]

    Lee, Fred; Ross, William

    1965-01-01T23:59:59.000Z

    STATUTORY INSTRUMENTS 1965 No. 1824 ATOMIC ENERGY AND RADIOACTIVE SUBSTANCES LICENSING AND REGULATION OF SITES The Nuclear Installations (Dangerous Occurrences) Regulations 1965...

  16. Aquifer Protection Area Land Use Regulations (Connecticut)

    Broader source: Energy.gov [DOE]

    These regulations describe allowable activities within aquifer protection areas, the procedure by which such areas are delineated, and relevant permit requirements. The regulations also describe...

  17. International Electricity Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation International Electricity Regulation U.S. trade in electric energy with Canada and Mexico is rising, bringing economic and reliability benefits to the United States and...

  18. Vermont Hazardous Waste Management Regulations (Vermont)

    Broader source: Energy.gov [DOE]

    These regulations are intended to protect public health and the environment by comprehensively regulating the generation, storage, collection, transport, treatment, disposal, use, reuse, and...

  19. Searchable Electronic Department of Energy Acquisition Regulation...

    Office of Environmental Management (EM)

    Searchable Electronic Department of Energy Acquisition Regulation Searchable Electronic Department of Energy Acquisition Regulation Updated July 2, 2013. The EDEAR is current...

  20. Virginia Electric Utility Regulation Act (Virginia)

    Broader source: Energy.gov [DOE]

    The Virginia Electric Utility Regulation Act constitutes the main legislation in Virginia that pertains to the regulation of the state's electric utilities. The Act directs the State Corporation...

  1. State Water Permit Regulation (Arkansas)

    Broader source: Energy.gov [DOE]

    It is the purpose of this regulation to adopt standards applicable to the storage, discharge, or disposal of any waste which, if unregulated, will cause pollution of waters of the state or result...

  2. DISPLAY SCREEN EQUIPMENT REGULATIONS 1992

    E-Print Network [OSTI]

    , charts or computer-generated graphics are included. Screens whose main use is to show television or film the standards required by the Regulations. 4 RISKS FROM USING DISPLAY SCREENS The principal risk associated when

  3. Water Quality Regulations (Rhode Island)

    Broader source: Energy.gov [DOE]

    The purpose of these regulations is to establish water quality standards for the state's surface waters. These standards are intended to restore, preserve and enhance the physical, chemical and...

  4. Kansas Air Quality Regulations (Kansas)

    Broader source: Energy.gov [DOE]

    All new air contaminant emission sources or alterations to emission sources that are required to be reported shall be in compliance with all applicable emission control regulations at the time that...

  5. Private Regulation of Consumer Arbitration

    E-Print Network [OSTI]

    Drahozal, Christopher R.; Zyontz, Samantha

    2012-01-01T23:59:59.000Z

    Arbitration providers, such as the American Arbitration Association (AAA) and JAMS, have promulgated due process protocols to regulate the fairness of consumer and employment arbitration agreements. A common criticism of these due process...

  6. Ground Water Management Regulations (Louisiana)

    Broader source: Energy.gov [DOE]

    The rules and regulations apply to the management of the state's ground water resources. In addition, the Commissioner of Conservation has recommended that oil and gas operators with an interest...

  7. Modellering og regulering af affaldsforbrnding

    E-Print Network [OSTI]

    deals with the regulation of a Danish waste incineration plant. It is tested if the flame front can on the Waste Incineration Plant, Haderslev Kraftvar- meværk in Denmark. Concurrently the position of the flame

  8. Negative feedback regulation of Homer 1a on norepinephrine-dependent cardiac hypertrophy

    SciTech Connect (OSTI)

    Chiarello, Carmelina; Bortoloso, Elena; Carpi, Andrea; Furlan, Sandra; Volpe, Pompeo, E-mail: pompeo.volpe@unipd.it

    2013-07-15T23:59:59.000Z

    Homers are scaffolding proteins that modulate diverse cell functions being able to assemble signalling complexes. In this study, the presence, sub-cellular distribution and function of Homer 1 was investigated. Homer 1a and Homer 1b/c are constitutively expressed in cardiac muscle of both mouse and rat and in HL-1 cells, a cardiac cell line. As judged by confocal immunofluorescence microscopy, Homer 1a displays sarcomeric and peri-nuclear localization. In cardiomyocytes and cultured HL-1 cells, the hypertrophic agonist norepinephrine (NE) induces ?{sub 1}-adrenergic specific Homer 1a over-expression, with a two-to-three-fold increase within 1 h, and no up-regulation of Homer 1b/c, as judged by Western blot and qPCR. In HL-1 cells, plasmid-driven over-expression of Homer 1a partially antagonizes activation of ERK phosphorylation and ANF up-regulation, two well-established, early markers of hypertrophy. At the morphometric level, NE-induced increase of cell size is likewise and partially counteracted by exogenous Homer 1a. Under the same experimental conditions, Homer 1b/c does not have any effect on ANF up-regulation nor on cell hypertrophy. Thus, Homer 1a up-regulation is associated to early stages of cardiac hypertrophy and appears to play a negative feedback regulation on molecular transducers of hypertrophy. -- Highlights: Homer 1a is constitutively expressed in cardiac tissue. In HL-1 cells, norepinephrine activates signaling pathways leading to hypertrophy. Homer 1a up-regulation is an early event of norepinephrine-induced hypertrophy. Homer 1a plays a negative feedback regulation modulating pathological hypertrophy. Over-expression of Homer 1a per se does not induce hypertrophy.

  9. OUTPUT REGULATION OF NONLINEAR NEUTRAL SYSTEMS

    E-Print Network [OSTI]

    Fridman, Emilia

    OUTPUT REGULATION OF NONLINEAR NEUTRAL SYSTEMS Emilia Fridman1 Department of Electrical Engineering, Tel-Aviv University Ramat-Aviv, Tel-Aviv 69978, Israel emilia@eng.tau.ac.il Summary. Output regulation regulation, regulator equations, center manifold 1 Introduction One of the most important problems in control

  10. Advanced Clean Cars Zero Emission Vehicle Regulation

    E-Print Network [OSTI]

    California at Davis, University of

    Advanced Clean Cars Zero Emission Vehicle Regulation ZEV #12;Advanced Clean Cars ZEV Program 2020 2021 2022 2023 2024 2025 Current Regulation -ZEVs Current Regulation -PHEVs Projected: PHEVs 15 infrastructure, the cars won't come Complementary Policies to support ZEV regulation Clean Fuels Outlet

  11. ,/ t"tSlifornla Energy Building Regulations

    E-Print Network [OSTI]

    J ,/ t"tSlifornla 'IOt'nergy Commission Energy Building Regulations for New Residential and Nonre (Energy Building Regulations) 1-1 #12;#12;Section TABLE OF CONTENTS Title Page 1401 1402 General.--ENERGY BUILDING REGULATIONS Section 1401. General. This article contains administrative regulations

  12. NOTICE OF REGULATION REPEAL Date: August 6, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: August 6, 2009 REGULATION TITLE: REGULATION NO.: Purchase and Sale of Real Property 6C7-7.202 SUMMARY OF REGULATION REPEAL: This regulation is not necessary and does REGULATION REPEAL: Regulations Administrator COMMENTS CONCERNING THE REGULATION REPEAL SHOULD BE SUBMITTED

  13. NOTICE OF REGULATION REPEAL Date: June 9, 2014

    E-Print Network [OSTI]

    Pattanaik, Sumanta N.

    NOTICE OF REGULATION REPEAL Date: June 9, 2014 REGULATION TITLE: REGULATION NO.: Tenure UCF-3.011 SUMMARY OF REGULATION REPEAL: This regulation is proposed for repeal because the material contained in this regulation has been moved to regulation UCF-3.015. AUTHORITY: BOG Regulations 1.001 NAME OF PERSON WHO

  14. NOTICE OF REGULATION REPEAL Date: May 24, 2010

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: May 24, 2010 REGULATION TITLE: REGULATION NO.: Conflict of Interest 6C7-3.008 SUMMARY OF REGULATION REPEAL: This regulation is proposed for repeal, because the material contained in this regulation has been moved to regulation UCF-3.018 AUTHORITY: BOG Regulation 1

  15. The Transcription Factor WIN1/SHN1 Regulates Cutin Biosynthesis in Arabidopsis thaliana W

    E-Print Network [OSTI]

    Pauly, Markus

    influence on its ability to protect the plant against various forms of biotic and abiotic stress. WAX INDUCER1 (WIN1) and related transcription factors have recently been shown to trigger wax production of genes associated with wax biosynthesis, suggesting that the regulation of cutin and wax production

  16. Administrative Regulation 9:1 Page 1 of 6 Administrative Regulation 9:1

    E-Print Network [OSTI]

    MacAdam, Keith

    Administrative Regulation 9:1 Page 1 of 6 Administrative Regulation 9:1 Responsible Office: Vice/3/1985 Regulations Governing Time, Place, and Manner of Meetings, Demonstrations, and Other Assemblies Regulation of their exercise and the rights of others in the effective use of University facilities, the following regulations

  17. NOTICE OF PROPOSED REGULATION AMENDMENT Date: April 15, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    REGULATION AMENDMENT: Philip Fairey, Deputy Director, Florida Solar Energy Center COMMENTS CONCERNINGNOTICE OF PROPOSED REGULATION AMENDMENT Date: April 15, 2009 REGULATION TITLE: REGULATION NO.: Solar Thermal Collector and PV Module Certification UCF-8.003 SUMMARY OF REGULATION AMENDMENT

  18. NOTICE OF PROPOSED REGULATION AMENDMENT Date: April 15, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    , Florida Solar Energy Center COMMENTS CONCERNING THE PROPOSED REGULATION AMENDMENT SHOULD BE SUBMITTEDNOTICE OF PROPOSED REGULATION AMENDMENT Date: April 15, 2009 REGULATION TITLE: REGULATION NO.: Solar Thermal and Photovoltaic System Standards UCF-8.005 and Certification SUMMARY OF REGULATION

  19. NOTICE OF PROPOSED REGULATION AMENDMENT Date: April 15, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    REGULATION AMENDMENT: Philip Fairey, Deputy Director, Florida Solar Energy Center COMMENTS CONCERNINGNOTICE OF PROPOSED REGULATION AMENDMENT Date: April 15, 2009 REGULATION TITLE: REGULATION NO.: Solar Thermal Collector and PV Module Testing Standards UCF-8.002 SUMMARY OF REGULATION AMENDMENT

  20. Improving Regulation Through Incremental Adjustment

    E-Print Network [OSTI]

    Glicksman, Robert L.; Shapiro, Sidney A.

    2004-03-01T23:59:59.000Z

    category or subcategory" to take account of data that EPA never considered in issuing the regulations and that render a particular discharger's situation fundamentally different from the ones EPA considered in the rulemaking. 40 C.F.R. 125.30(b) (2003...-77 (1986). 67. 42 U.S.c. 6921(a), (b)(1) (2000). 68. [d. 6922-6924. 69. [d. 6921(f)(1). 70. 40 c.F.R. 260.22(a)(1) (2003). EPA regulations also provide a mechanism for the filing of petitions to add a hazardous waste to the list. [d. 260...

  1. Genomic neighbourhood and the regulation of gene expression Genomic neighbourhood and transcriptional regulation

    E-Print Network [OSTI]

    Babu, M. Madan

    Genomic neighbourhood and the regulation of gene expression Genomic neighbourhood and transcriptional regulation Subhajyoti De and M. Madan Babu MRC Laboratory of Molecular Biology, Hills Road..................................................................................................................................................................................1 2. Genomic neighbourhood and its influence on gene regulation

  2. Naturalistic emotion regulation: The measurement and social consequences of spontaneous emotion regulation during marital conflict.

    E-Print Network [OSTI]

    Bloch, Lian Michal

    2011-01-01T23:59:59.000Z

    On the Nature of Emotion Regulation. Child Development, 75(2011). Reconceptualizing emotion regulation. Emotion Review.L.L. (2007). Emotion regulation and aging. In J.J. Gross (

  3. Implementation Regulations 3TU MSc Sustainable Energy Technology Delft, 2014-2015 THE IMPLEMENTATION REGULATIONS

    E-Print Network [OSTI]

    Implementation Regulations 3TU MSc Sustainable Energy Technology Delft, 2014-2015 THE IMPLEMENTATION REGULATIONS 2014 - 2015 3TU MASTER'S DEGREE PROGRAMME Sustainable Energy Technology - Delft (SET) DELFT UNIVERSITY OF TECHNOLOGY #12;Implementation Regulations MSc Sustainable Energy Technology SET

  4. Emotion Regulation as Situated Conceptualizations 1 RUNNING HEAD: EMOTION REGULATION AS SITUATED CONCEPTUALIZATIONS

    E-Print Network [OSTI]

    Barsalou, Lawrence W.

    Emotion Regulation as Situated Conceptualizations 1 RUNNING HEAD: EMOTION REGULATION AS SITUATED CONCEPTUALIZATIONS TITLE: A psychological construction account of emotion regulation and dysregulation: The role of situated conceptualizations Lisa Feldman Barrett Northeastern University; Massachusetts General Hospital

  5. Cavitation-resistant inducer

    DOE Patents [OSTI]

    Dunn, Charlton (Calabasas, CA); Subbaraman, Maria R. (Canoga Park, CA)

    1989-01-01T23:59:59.000Z

    An improvement in an inducer for a pump wherein the inducer includes a hub, a plurality of radially extending substantially helical blades and a wall member extending about and encompassing an outer periphery of the blades. The improvement comprises forming adjacent pairs of blades and the hub to provide a substantially rectangular cross-sectional flow area which cross-sectional flow area decreases from the inlet end of the inducer to a discharge end of the inducer, resulting in increased inducer efficiency improved suction performance, reduced susceptibility to cavitation, reduced susceptibility to hub separation and reduced fabrication costs.

  6. Cavitation-resistant inducer

    DOE Patents [OSTI]

    Dunn, C.; Subbaraman, M.R.

    1989-06-13T23:59:59.000Z

    An improvement in an inducer for a pump is disclosed wherein the inducer includes a hub, a plurality of radially extending substantially helical blades and a wall member extending about and encompassing an outer periphery of the blades. The improvement comprises forming adjacent pairs of blades and the hub to provide a substantially rectangular cross-sectional flow area which cross-sectional flow area decreases from the inlet end of the inducer to a discharge end of the inducer, resulting in increased inducer efficiency improved suction performance, reduced susceptibility to cavitation, reduced susceptibility to hub separation and reduced fabrication costs. 11 figs.

  7. Advanced Workshop in Regulation and

    E-Print Network [OSTI]

    Lin, Xiaodong

    Forces in Regulated Industries January 14, 2010 Smart Grid and Regulatory Issues Rutgers University 1, "Utility DR in Deregulated Markets" 11:50-12:20 James Reitzes, The Brattle Group, "Smart Grid/Smart and the Smart Grid" 1:50 ­ 2:20 Howard Spinner, Virginia State Corporation Commission, "Smart Grid in Virginia

  8. REGULATION SCOPING Alternative and Renewable

    E-Print Network [OSTI]

    guidelines, definitions, and other provisions necessary for the administration of the Program Assessment · Fuel and Vehicle Technology Definitions · Sustainability Goals · Revenue Streams · Measure Program Results · AntiBacksliding Guidelines (Regulations developed by the Air Resources Board [ARB

  9. California Energy Commission PROPOSED REGULATIONS

    E-Print Network [OSTI]

    the amount of electricity generated and procured from nonrenewable energy sources, such as fossil fuelbased of fossil fuels and the associated environmental impacts and by reducing instate fossil fuel consumptionCalifornia Energy Commission PROPOSED REGULATIONS SUPPORTING MATERIAL FOR THE ECONOMIC

  10. REGULATIONS OF UNIVERSITY OF FLORIDA

    E-Print Network [OSTI]

    Pilyugin, Sergei S.

    REGULATIONS OF UNIVERSITY OF FLORIDA 6C1-3.0051 Lost or Abandoned Property. (1) For the purposes and Archer Road on the south, along with any other educational or residential facilities occupied as the date on which an identified owner of lost or abandoned property is notified by the Property Custodian

  11. Regulation of DNA repair by parkin

    SciTech Connect (OSTI)

    Kao, Shyan-Yuan, E-mail: shyan-yuan_kao@meei.harvard.edu [Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114 (United States)] [Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114 (United States)

    2009-05-01T23:59:59.000Z

    Mutation of parkin is one of the most prevalent causes of autosomal recessive Parkinson's disease (PD). Parkin is an E3 ubiquitin ligase that acts on a variety of substrates, resulting in polyubiquitination and degradation by the proteasome or monoubiquitination and regulation of biological activity. However, the cellular functions of parkin that relate to its pathological involvement in PD are not well understood. Here we show that parkin is essential for optimal repair of DNA damage. Parkin-deficient cells exhibit reduced DNA excision repair that can be restored by transfection of wild-type parkin, but not by transfection of a pathological parkin mutant. Parkin also protects against DNA damage-induced cell death, an activity that is largely lost in the pathological mutant. Moreover, parkin interacts with the proliferating cell nuclear antigen (PCNA), a protein that coordinates DNA excision repair. These results suggest that parkin promotes DNA repair and protects against genotoxicity, and implicate DNA damage as a potential pathogenic mechanism in PD.

  12. NOTICE OF REGULATION REPEAL Date: May 5, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: May 5, 2009 REGULATION TITLE: REGULATION NO.: Student Rights and Responsibilities 6C7-5.003 SUMMARY OF REGULATION REPEAL: This regulation is being repealed. New regulations OF PERSON WHO INITIATED REGULATION REPEAL: Patricia MacKown, Director, Office of Student Rights

  13. NOTICE OF REGULATION REPEAL Date: August 6, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: August 6, 2009 REGULATION TITLE: REGULATION NO.: Rental Rates 6C7-7.219 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal because the subject matter of the regulation is not needed and is out of date. Florida Board of Governors Regulation 17.001 requires

  14. NOTICE OF REGULATION REPEAL Date: June 9, 2014

    E-Print Network [OSTI]

    Pattanaik, Sumanta N.

    NOTICE OF REGULATION REPEAL Date: June 9, 2014 REGULATION TITLE: REGULATION NO.: Promotion of Tenured and Tenure-earning faculty UCF-3.017 SUMMARY OF REGULATION REPEAL: This regulation is proposed for repeal because the material contained in this regulation has been moved to regulation UCF-3

  15. Petroleum: The Petroleum (Production) (Amendment) Regulations, 1957

    E-Print Network [OSTI]

    Her Majesty's Stationary Office

    1957-01-01T23:59:59.000Z

    These Regulations amend the Petroleum (Production) Regulations, 1935, which set out the requirements for applications for, and the model clauses to be incorporated in, prospecting and mining licences issued under the Petroleum (Production) Act, 1934...

  16. Stream Flow Standards and Regulations (Connecticut)

    Broader source: Energy.gov [DOE]

    These regulations apply to all rivers and streams in Connecticut. Dam owners need to comply with these regulations unless the dam is principally used for hydroelectric power generation and is under...

  17. Solid Waste and Infectious Waste Regulations (Ohio)

    Broader source: Energy.gov [DOE]

    This chapter of the law that establishes the Ohio Environmental Protection Agency establishes the rules and regulations regarding solid waste.

  18. Allele-specific gene regulation in humans

    E-Print Network [OSTI]

    Maynard, Nathaniel David

    2008-01-01T23:59:59.000Z

    regulation. 4.4 Acknowledgements Professor Zhiping Wang and Hualin Xi of Boston University and University of Massachusetts,

  19. Reformulating Competition? Gasoline Content Regulation and Wholesale Gasoline Prices

    E-Print Network [OSTI]

    Brown, Jennifer; Hastings, Justine; Mansur, Erin T.; Villas-Boas, Sofia B

    2007-01-01T23:59:59.000Z

    Regulation and Arbitrage in Wholesale Gasoline Markets,Content Regulation and Wholesale Gasoline Prices JenniferCONTENT REGULATION AND WHOLESALE GASOLINE PRICES by Jennifer

  20. Regulation of Tidal and Wave Energy Projects (Maine)

    Broader source: Energy.gov [DOE]

    State regulation of tidal and wave energy projects is covered under the Maine Waterway Development and Conservation Act (MWDCA), and complements regulation by the Federal Energy Regulation...

  1. Regulation and the High Cost of Housing in California

    E-Print Network [OSTI]

    Quigley, John M.; Raphael, Steven

    2006-01-01T23:59:59.000Z

    C. Tsuriel. Land Use Regulations and New Construc- tion. local government land use regulation. Cam- The Effects offrequently the target of regulation. REFERENCES Glickfeld,

  2. Land use regulation and intraregional population-employment interaction

    E-Print Network [OSTI]

    Kim, JH; Hewings, GJD

    2013-01-01T23:59:59.000Z

    Levine J (2006) Zoned out: Regulation, markets, and choicesprices, externalities, and regulation in U.S. metropolitanCT (2000) Land use regulation and new construction. Regional

  3. A Computational Model for Adaptive Emotion Regulation

    E-Print Network [OSTI]

    Treur, Jan

    A Computational Model for Adaptive Emotion Regulation Tibor Bosse, Matthijs Pontier, and Jan Treur} Abstract. Emotion regulation describes how a subject can use certain strategies to affect emotion response levels. Usually, models for emotion regulation as- sume mechanisms based on feedback loops that indicate

  4. Army Regulation 2555 Information Management: Records

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 2555 Information Management: Records Management The Department of the Army Freedom Incorporates the Interim Change No. I01, which expires 30 June 1996 into the baseline regulation dated 10 of Information Act Program *Army Regulation 2555 Effective 1 December 1997 History. This revision was originally

  5. 2013-2014 Case Summaries Regulation 1

    E-Print Network [OSTI]

    Royer, Dana

    2013-2014 Case Summaries Regulation 1 Disturbance of the Peace the infringement upon the right that repeated violation of this regulation could result in administrative reassignment to another residential violated Section II, Regulations 1 and 14 of the Code of Non-Academic Conduct. The board found the group

  6. Regulation of Hydraulic Fracturing in California

    E-Print Network [OSTI]

    Kammen, Daniel M.

    APRIL 2013 Regulation of Hydraulic Fracturing in California: A WAsteWAteR And WAteR QuAlity Pe | Regulation of Hydraulic Fracturing in California Wheeler Institute for Water Law & Policy Center for Law #12;Regulation of Hydraulic Fracturing in California | 3Berkeley law | wheeler InstItute for water law

  7. California Energy Commission REVISED DRAFT REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission REVISED DRAFT REGULATIONS AUGUST, 2011 CEC-400-2010-004-SD2 Nonresidential Building Energy Use Disclosure Program Draft Regulations Title 20, Division 2, Chapter 4 of the California Energy Commission is releasing draft regulations for implementing Assembly Bill (AB) 1103 (Saldaa

  8. NARUC: Regulation at the crossroads

    SciTech Connect (OSTI)

    Not Available

    1990-01-04T23:59:59.000Z

    This article reports on the review of changes during the last decade of the regulation of industries by the federal government. The state commissioners that make up the National Association of Regulatory Utility Commissioners discuss the changing regulatory climate for a competitive industry, changes in the federal-state relationship, proposed changes in jurisdictional boundaries, acid rain legislation and emissions trading, and Senator J. Bennet Johnson's amendment to the Public Utilities Holding Company Act.

  9. Frequency regulator for synchronous generators

    DOE Patents [OSTI]

    Karlicek, R.F.

    1982-08-10T23:59:59.000Z

    The present invention is directed to a novel frequency regulator which controls a generator output frequency for variations in both the input power to the generator and the power supplied to an uncontrolled external load. The present invention further includes over current and current balance protection devices which are relatively inexpensive to manufacture, which may be encapsulated to provide protection from the operating environment and which respond more quickly than previously known electromechanical devices. 11 figs.

  10. Final Report for Regulation of Embryonic Development in Higher Plants

    SciTech Connect (OSTI)

    Harada, John J. [University of California, Davis] [University of California, Davis

    2013-10-22T23:59:59.000Z

    The overall goal of the project was to define the cellular processes that underlie embryo development in plants at a mechanistic level. Our studies focused on a critical transcriptional regulator, Arabidopsis LEAFY COTYLEDON (LEC1), that is necessary and sufficient to induce processes required for embryo development. Because LEC1 regulates lipid accumulation during the maturation phase of embryo development, information about LEC1 may be useful in designing approaches to enhance biofuel production in plants. During the tenure of this project, we determined the molecular mechanisms by which LEC1 acts as a transcription factor in embryos. We also identified genes directly regulated by LEC1 and showed that many of these genes are involved in maturation processes. This information has been useful in dissecting the gene regulatory networks controlling embryo development. Finally, LEC1 is a novel isoform of a transcription factor that is conserved among eukaryotes, and LEC1 is active primarily in seeds. Therefore, we determined that the LEC1-type transcription factors first appeared in lycophytes during land plant evolution. Together, this study provides basic information that has implications for biofuel production.

  11. TL1A induces the expression of TGF-b-inducible gene h3 (big-h3) through PKC, PI3K, and ERK in THP-1 cells

    E-Print Network [OSTI]

    Lee, Won-Ha

    TL1A induces the expression of TGF-b-inducible gene h3 (big-h3) through PKC, PI3K, and ERK in THP-1 of protein kinase C (PKC), extracellular signal-regulated kinase (ERK), phosphoinositide kinase-3 (PI3K blocked the phos- phorylation of AKT without affecting ERK phosphorylation. On the other hand, suppression

  12. DEPARTMENT OF PESTICIDE REGULATION http://www.clemson.edu/public/regulatory/pesticide_regulation/

    E-Print Network [OSTI]

    Stuart, Steven J.

    DEPARTMENT OF PESTICIDE REGULATION http://www.clemson.edu/public/regulatory/pesticide_regulation/ The Department of Pesticide Regulation (DPR) is the South Carolina regulatory and investigative agency Westinghouse Road Pendleton, SC 29670 TEL: 864-646-2151 FAX: 864-646-2179 Department of Pesticide Regulation

  13. Assessing Emotion Regulation in Social Anxiety Disorder: The Emotion Regulation Interview

    E-Print Network [OSTI]

    Gross, James J.

    Assessing Emotion Regulation in Social Anxiety Disorder: The Emotion Regulation Interview Kelly H dysregulation in SAD has not been well characterized. In the present study, the Emotion Regulation Interview (ERI) was developed to quantify the frequency and self-efficacy of five emotion regulation strategies

  14. IMPLICIT EVALUATION OF EMOTION REGULATION 1 Running Head: IMPLICIT EVALUATION OF EMOTION REGULATION

    E-Print Network [OSTI]

    Gross, James J.

    IMPLICIT EVALUATION OF EMOTION REGULATION 1 Running Head: IMPLICIT EVALUATION OF EMOTION REGULATION How to Bite Your Tongue without Blowing Your Top: Implicit Evaluation of Emotion Regulation Predicts EVALUATION OF EMOTION REGULATION 2 Abstract People frequently have to control their emotions to function

  15. Administrative Regulation 6:4 Page 1 of 6 Administrative Regulation 6:4

    E-Print Network [OSTI]

    MacAdam, Keith

    Administrative Regulation 6:4 Page 1 of 6 Administrative Regulation 6:4 Responsible Office: EVPFA. Introduction This regulation establishes the University's policies and procedures for using, serving, local ordinances, and University regulations. All members of the University community shall abide

  16. Friction Induced Skin Tags

    E-Print Network [OSTI]

    Allegue, Francisco; Fachal, Carmen; Prez-Prez, Lidia

    2008-01-01T23:59:59.000Z

    Duplantis KL, Jones BH. Friction blisters. Pathophysiology,Friction Induced Skin Tags Francisco Allegue MD 1 , Carmenetiopathogenic role for friction. Introduction Skin tags (

  17. Forms Supplement page -1 Export Administration Regulations January 2001

    E-Print Network [OSTI]

    Bernstein, Daniel

    Forms Supplement page - 1 Export Administration Regulations January 2001 #12;Forms Supplement page - 2 Export Administration Regulations January 2001 #12;Forms Supplement page - 3 Export Administration Regulations January 2001 #12;Forms Supplement page - 4 Export Administration Regulations January 2001 #12

  18. Dynamics of the Oil Transition: Modeling Capacity, Costs, and Emissions

    E-Print Network [OSTI]

    Brandt, Adam R.; Farrell, Alexander E.

    2008-01-01T23:59:59.000Z

    entirely from steam-induced heavy oil production in Cali-from Venezuelas extra-heavy oil reached about 0.6 Mbbl/d inliquid fuels. Heavy and extra-heavy oil are very viscous and

  19. Comparing Emissions Benefits from Regulating Heavy Vehicle Idling...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from Regulating Heavy Vehicle Idling Comparing Emissions Benefits from Regulating Heavy Vehicle Idling 2005 Diesel Engine Emissions Reduction (DEER) Conference...

  20. Systems analysis of multiple regulator perturbations allows discoveryo...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems analysis of multiple regulator perturbations allows discoveryof virulence factors in Salmonella. Systems analysis of multiple regulator perturbations allows discoveryof...

  1. Frequency Regulation Basics and Trends

    SciTech Connect (OSTI)

    Kirby, BJ

    2005-05-06T23:59:59.000Z

    The electric power system must address two unique requirements: the need to maintain a near real-time balance between generation and load, and the need to adjust generation (or load) to manage power flows through individual transmission facilities. These requirements are not new: vertically integrated utilities have been meeting them for a century as a normal part of conducting business. With restructuring, however, the services needed to meet these requirements, now called ''ancillary services'', are being more clearly defined. Ancillary services are those functions performed by the equipment and people that generate, control, and transmit electricity in support of the basic services of generating capacity, energy supply, and power delivery. The Federal Energy Regulatory Commission (FERC) has defined such services as those ''necessary to support the transmission of electric power from seller to purchaser given the obligations of control areas and transmitting utilities within those control areas to maintain reliable operations of the interconnected transmission system''. This statement recognizes the importance of ancillary services for both bulk-power reliability and support of commercial transactions. Balancing generation and load instantaneously and continuously is difficult because loads and generators are constantly fluctuating. Minute-to-minute load variability results from the random turning on and off of millions of individual loads. Longer-term variability results from predictable factors such as the daily and seasonal load patterns as well as more random events like shifting weather patterns. Generators also introduce unexpected fluctuations because they do not follow their generation schedules exactly and they trip unexpectedly due to a range of equipment failures. The output from wind generators varies with the wind. Storage technologies should be ideal suppliers of several ancillary services, including regulation, contingency reserves (spinning reserve, supplemental reserve, replacement reserve), and voltage support. These services are not free; in regions with energy markets, generators are paid to supply these services. In vertically integrated utilities (without energy markets) the utility incurs significant costs to supply these services. Supplying these services may be a significant business opportunity for emerging storage technologies. This report briefly explores the various ancillary services that may be of interest to storage. It then focuses on regulation, the most expensive ancillary service. It also examines the impact that increasing amounts of wind generation may have on regulation requirements, decreasing conventional regulation supplies, and the implications for energy storage.

  2. Federal Regulations | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you sure you want toworldPowerHome |CookingFAQsFacilityFederal Regulations

  3. NOTICE OF REGULATION REPEAL Date: August 6, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: August 6, 2009 REGULATION TITLE: REGULATION NO.: Certification of Compliance - Leases 6C7-7.216 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal because the subject matter of the regulation is not needed and is out of date. AUTHORITY: BOG Resolution dated January

  4. NOTICE OF REGULATION REPEAL Date: August 6, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: August 6, 2009 REGULATION TITLE: REGULATION NO.: Code Compliance in Lease Space 6C7-7.207 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal due to the inclusion of the relevant information in the proposed amendment to regulation UCF-7.203. AUTHORITY: BOG

  5. NOTICE OF REGULATION REPEAL Date: August 6, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: August 6, 2009 REGULATION TITLE: REGULATION NO.: Approval of Real Property Leases 6C7-7.205 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal due to the inclusion of the relevant information in the proposed amendment to regulation UCF-7.203. AUTHORITY: BOG

  6. NOTICE OF REGULATION REPEAL Date: July 9, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: July 9, 2009 REGULATION TITLE: REGULATION NO.: Grievance Procedures for Non-unit Faculty and UCF-3.0132 A&P Staff Members SUMMARY OF REGULATION REPEAL: This regulation is being repealed. New regulations are being adopted that will cover the subject matter. AUTHORITY

  7. NOTICE OF REGULATION REPEAL Date: February 26, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: February 26, 2009 REGULATION TITLE: REGULATION NO.: Space Allocation 6C7-7.218 SUMMARY OF REGULATION REPEAL: This regulation is being repealed. The subject matter of regulation 6C7-7.218 is addressed by the Board of Governors. AUTHORITY: BOG Resolution dated January 7, 2003

  8. NOTICE OF REGULATION REPEAL Date: July 31, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: July 31, 2009 REGULATION TITLE: REGULATION NO.: Exception to Competitive Bidding for Leased Space 6C7-7.220 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal due to the inclusion of the relevant information in the proposed amendment to regulation UCF-7

  9. NOTICE OF REGULATION REPEAL Date: July 31, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: July 31, 2009 REGULATION TITLE: REGULATION NO.: Evaluation of Lease Proposals 6C7-7.212 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal due to the inclusion of the relevant information in the proposed amendment to regulation UCF-7.209. AUTHORITY: BOG

  10. NOTICE OF REGULATION REPEAL Date: August 6, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: August 6, 2009 REGULATION TITLE: REGULATION NO.: Standard Lease Agreement Form 6C7-7.206 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal due to the inclusion of the relevant information in the proposed amendment to regulation UCF-7.203. AUTHORITY: BOG

  11. NOTICE OF REGULATION REPEAL Date: May 8, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: May 8, 2009 REGULATION TITLE: REGULATION NO.: Confidential Information Policy for Faculty 6C73.030 SUMMARY OF REGULATION REPEAL: This regulation is being repealed NAME OF PERSON WHO INITIATED REGULATION REPEAL: Mark Roberts, Director, Human Resources COMMENTS

  12. NOTICE OF REGULATION REPEAL Date: July 31, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: July 31, 2009 REGULATION TITLE: REGULATION NO.: Proposals to Lease 6C7-7.211 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal due to the inclusion of the relevant information in the proposed amendment to regulation UCF-7.209. AUTHORITY: BOG Resolution dated

  13. NOTICE OF REGULATION REPEAL Date: August 6, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: August 6, 2009 REGULATION TITLE: REGULATION NO.: Space Measurement 6C7-7.217 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal due to the inclusion of the relevant information in the proposed amendment to regulation UCF-7.203. AUTHORITY: BOG Resolution dated

  14. NOTICE OF REGULATION REPEAL Date: August 6, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    NOTICE OF REGULATION REPEAL Date: August 6, 2009 REGULATION TITLE: REGULATION NO.: Definitions 6C7-7.204 SUMMARY OF REGULATION REPEAL: This regulation is noticed for repeal due to the inclusion of the relevant information in the proposed amendment to regulation UCF-7.203. AUTHORITY: BOG Resolution dated January 7, 2003

  15. NOTICE OF REGULATION REPEAL Date: July 1, 2010

    E-Print Network [OSTI]

    Wu, Shin-Tson

    . James Fenton, Director, Florida Solar Energy Center COMMENTS CONCERNING THE REGULATION REPEAL SHOULDNOTICE OF REGULATION REPEAL Date: July 1, 2010 REGULATION TITLE: REGULATION NO.: Solar Thermal Collector and PV Module UCF-8.002 Testing Standards SUMMARY OF REGULATION REPEAL: This regulation

  16. NOTICE OF REGULATION REPEAL Date: July 1, 2010

    E-Print Network [OSTI]

    Wu, Shin-Tson

    , Florida Solar Energy Center COMMENTS CONCERNING THE REGULATION REPEAL SHOULD BE SUBMITTED WITHIN 14 DAYSNOTICE OF REGULATION REPEAL Date: July 1, 2010 REGULATION TITLE: REGULATION NO.: Solar Thermal Collector and PV Module UCF-8.003 Certification SUMMARY OF REGULATION REPEAL: This regulation is proposed

  17. NOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005

    E-Print Network [OSTI]

    Wu, Shin-Tson

    Director of Florida Solar Energy Center COMMENTS CONCERNING THE PROPOSED REGULATION AMENDMENT SHOULDNOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005 REGULATION TITLE: REGULATION NO.: Testing Fees, Testing, Inspection, Services 6C7-8.004 SUMMARY OF REGULATION AMENDMENT: This regulation has

  18. NOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005

    E-Print Network [OSTI]

    Wu, Shin-Tson

    PROPOSED REGULATION AMENDMENT: Philip Fairey, Deputy Director of Florida Solar Energy Center COMMENTSNOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005 REGULATION TITLE: REGULATION NO.: Solar Collector Certification 6C7-8.003 SUMMARY OF REGULATION AMENDMENT: This regulation is revised

  19. NOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005

    E-Print Network [OSTI]

    Wu, Shin-Tson

    PROPOSED REGULATION AMENDMENT: Philip Fairey, Deputy Director of Florida Solar Energy Center COMMENTSNOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005 REGULATION TITLE: REGULATION NO.: Solar Collector Testing Standards 6C7-8.002 SUMMARY OF REGULATION AMENDMENT: This regulation is revised

  20. NOTICE OF REGULATION REPEAL Date: July 1, 2010

    E-Print Network [OSTI]

    Wu, Shin-Tson

    . James Fenton, Director, Florida Solar Energy Center COMMENTS CONCERNING THE REGULATION REPEAL SHOULDNOTICE OF REGULATION REPEAL Date: July 1, 2010 REGULATION TITLE: REGULATION NO.: Solar Thermal and Photovoltaic System UCF-8.005 Standards and Certification SUMMARY OF REGULATION REPEAL: This regulation

  1. NOTICE OF REGULATION REPEAL Date: July 1, 2010

    E-Print Network [OSTI]

    Wu, Shin-Tson

    Fenton, Director, Florida Solar Energy Center COMMENTS CONCERNING THE REGULATION REPEAL SHOULDNOTICE OF REGULATION REPEAL Date: July 1, 2010 REGULATION TITLE: REGULATION NO.: Fees for Testing, Certification, Inspection and UCF-8.004 Services SUMMARY OF REGULATION REPEAL: This regulation is proposed

  2. Radiation-induced gene responses

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.; Shearin-Jones, P.; Oryhon, J.

    1996-12-31T23:59:59.000Z

    In the process of identifying genes that are differentially regulated in cells exposed to ultraviolet radiation (UV), we identified a transcript that was repressed following the exposure of cells to a combination of UV and salicylate, a known inhibitor of NF-kappaB. Sequencing this band determined that it has identify to lactate dehydrogenase, and Northern blots confirmed the initial expression pattern. Analysis of the sequence of the LDH 5` region established the presence of NF-kappaB, Sp1, and two Ap-2 elements; two partial AP- 1; one partial RE, and two halves of E-UV elements were also found. Electromobility shift assays were then performed for the AP-1, NF- kappaB, and E-UV elements. These experiments revealed that binding to NF-kappaB was induced by UV but repressed with salicylic acid; UV did not affect AP-1 binding, but salicylic acid inhibited it alone or following UV exposure; and E-UV binding was repressed by UV, and salicylic acid had little effect. Since the binding of no single element correlated with the expression pattern of LDH, it is likely that multiple elements govern UV/salicylate-mediated expression.

  3. Endocrine regulation of placental phenotype

    E-Print Network [OSTI]

    Fowden, A.L.; Forhead, A.J.; Sferruzzi-Perri, A.N.; Burton, G. J.; Vaughan, O.R.

    2014-12-03T23:59:59.000Z

    acids (131, 132). The 221 hormonally induced changes in trophoblast surface area, thickness and vascularity will also 222 influence the passive diffusion properties of the placenta and, hence, transport by simple 223 diffusion of oxygen and waste... 455 pregnancy in the ewe: rates of protein secretion and synthesis and nuclear and cytosol 456 steroid hormone receptor levels. J Endocrinol 1983; 96:137-146. 457 25 Ogle TF Characteristics of high affinity progesterone binding to rat placental...

  4. The Arabidopsis blue light receptor cryptochrome 2 is a nuclear protein regulated by a blue light-dependent post-

    E-Print Network [OSTI]

    Lin, Chentao

    The Arabidopsis blue light receptor cryptochrome 2 is a nuclear protein regulated by a blue light Charles E. Young Dr. South, Los Angeles, CA 90095-1606, USA Summary Cryptochrome 2 is a ¯avin-type blue light receptor mediating ¯oral induction in response to photoperiod and a blue light-induced hypocotyl

  5. Un teatro campesino en Venezuela

    E-Print Network [OSTI]

    Korn, Guillermo

    1976-10-01T23:59:59.000Z

    Universidad Central que hace observaciones de campo en Sabaneta. Los que fuimos desde Caracas. Se colman todos los asientos: bancos, sillas. Se anuncia que se va a representar El viejo Los actores ocupan sus puestos. El Coro cubre la escalera. Ya es de... noche. Dos focos elctricos situados a la derecha, en el muro de la casa iluminan lateralmente la escena. Coro: Aqu est el Grupo Sabaneta! Todos unidos como una cadena! Unidos venceremos! Primera escena: El Viejo, sentado conversa con la hija...

  6. UNIVERSIDAD SIMN BOLVAR Caracas -Venezuela

    E-Print Network [OSTI]

    Vsquez, Carlos

    .............................................................. Desarrollo Estudiantil Programas de Bienestar Social Programa de Salud Programa de Orientacin y

  7. UNIVERSIDAD SIMN BOLVAR Caracas -Venezuela

    E-Print Network [OSTI]

    Vsquez, Carlos

    .............................................................. Desarrollo Estudiantil Programas de Bienestar Social Programa de Orientacin y Asesoramiento

  8. Dynamic Voltage Regulation Using Distributed Energy Resources

    SciTech Connect (OSTI)

    Xu, Yan [ORNL; Rizy, D Tom [ORNL; Li, Fangxing [ORNL; Kueck, John D [ORNL

    2007-01-01T23:59:59.000Z

    Many distributed energy resources (DE) are near load centres and equipped with power electronics converters to interface with the grid, therefore it is feasible for DE to provide ancillary services such as voltage regulation, nonactive power compensation, and power factor correction. A synchronous condenser and a microturbine with an inverter interface are implemented in parallel in a distribution system to regulate the local voltage. Voltage control schemes of the inverter and the synchronous condenser are developed. The experimental results show that both the inverter and the synchronous condenser can regulate the local voltage instantaneously, while the dynamic response of the inverter is faster than the synchronous condenser; and that integrated voltage regulation (multiple DE perform voltage regulation) can increase the voltage regulation capability, increase the lifetime of the equipment, and reduce the capital and operation costs.

  9. Inland Wetlands and Water Courses Regulations (Connecticut)

    Broader source: Energy.gov [DOE]

    Regulated activities in or near inland wetlands and water courses include the removal or depositing of material, land or water obstruction or alteration, construction, pollution, or water diversion...

  10. Air Quality Regulations (Pennsylvania) | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    as pollution control devices, boilers, fuels and paints at 3,650 facilities that produce air pollution in Pennsylvania. The program administers the rules and regulations of the...

  11. Massachusetts Endangered Species Act Regulations (Massachusetts)

    Broader source: Energy.gov [DOE]

    The regulations that accompany the Massachusetts Endangered Species Act list three categories of animals and plants in need of protection: endangered, threatened, and species of special concern....

  12. Gas and Electric Utilities Regulation (South Dakota)

    Broader source: Energy.gov [DOE]

    This legislation contains provisions for gas and electric utilities. As part of these regulations, electric utilities are required to file with the Public Utilities Commission a document regarding...

  13. Council on Environmental Quality - Regulations for Implementing...

    Open Energy Info (EERE)

    OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Council on Environmental Quality - Regulations for Implementing the Procedural Provisions of the NEPALegal...

  14. Water Pollution Control Permit Regulations (Vermont)

    Broader source: Energy.gov [DOE]

    These regulations outline the permits and permitting processes for point discharges to surface waters and outline the monitoring and reporting requirements.

  15. Rhode Island Pretreatment Regulations (Rhode Island)

    Broader source: Energy.gov [DOE]

    These regulations set standards for water pretreatment prior to release to Publicly Owned Treatment Works (POTWs), and require effluent data including the identity, amount, frequency, concentration...

  16. Regulations for Air Quality (Quebec, Canada)

    Broader source: Energy.gov [DOE]

    This Regulation establishes emission standards for particulates and gases, emission opacity standards, standards of air quality and control measures to prevent, eliminate or reduce the emission of...

  17. 2011 Revised Regulation FCOI Webinar for Grantees

    E-Print Network [OSTI]

    Bandettini, Peter A.

    2011 Revised Regulation FCOI Webinar for Grantees Provided by the National Institutes of Health Overview of Other Changes Grantee Institution Responsibilities Noncompliance Submitting FCOI Reports

  18. Exporting licensing regulations affecting US geothermal firms

    SciTech Connect (OSTI)

    Not Available

    1988-08-01T23:59:59.000Z

    This document presents a brief introduction and overview of the Department of Commerce's Export Administration Regulations which might affect potential US geothermal goods exporters. It is intended to make US geothermal firms officials aware of the existence of such regulations and to provide them with references, contacts and phone numbers where they can obtain specific and detailed information and assistance. It must be stressed however, that the ultimate responsibility for complying with the above mentioned regulations lies with the exporter who must consult the complete version of the regulations.

  19. Solid Waste Regulations (Nova Scotia, Canada)

    Broader source: Energy.gov [DOE]

    Nova Scotia Environment administers waste management for the province. Regulations include specific rules and standards for landfills, establish a Resource Recovery Fund, and guidelines for...

  20. Chk2 regulates transcription-independent p53-mediated apoptosis in response to DNA damage

    SciTech Connect (OSTI)

    Chen Chen [Department of Geriatric Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522 (Japan); Shimizu, Shigeomi [Department of Post-Genomics Diseases, Osaka University Medical School, Suita, Osaka 565-0871 (Japan); Tsujimoto, Yoshihide [Department of Post-Genomics Diseases, Osaka University Medical School, Suita, Osaka 565-0871 (Japan); Motoyama, Noboru [Department of Geriatric Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522 (Japan)]. E-mail: motoyama@nils.go.jp

    2005-07-29T23:59:59.000Z

    The tumor suppressor protein p53 plays a central role in the induction of apoptosis in response to genotoxic stress. The protein kinase Chk2 is an important regulator of p53 function in mammalian cells exposed to ionizing radiation (IR). Cells derived from Chk2-deficient mice are resistant to the induction of apoptosis by IR, and this resistance has been thought to be a result of the defective transcriptional activation of p53 target genes. It was recently shown, however, that p53 itself and histone H1.2 translocate to mitochondria and thereby induces apoptosis in a transcription-independent manner in response to IR. We have now examined whether Chk2 also regulates the transcription-independent induction of apoptosis by p53 and histone H1.2. The reduced ability of IR to induce p53 stabilization in Chk2-deficient thymocytes was associated with a marked impairment of p53 and histone H1 translocation to mitochondria. These results suggest that Chk2 regulates the transcription-independent mechanism of p53-mediated apoptosis by inducing stabilization of p53 in response to IR.

  1. Law, Justice and Regulation at UEA law-justice-regulation@uea.ac.uk

    E-Print Network [OSTI]

    Everest, Graham R

    .dewing@uea.ac.uk Ivan Diaz-Rainey (NBS) Regulation of energy and environmental markets http://www.uea.ac.uk/nbs/people/People/Academic/Ivan+Diaz- Rainey i.diaz-rainey@uea.ac.uk Catherine Wad- dams (NBS/CCP) Economic regulation, competition, energy1 Network on Law, Justice and Regulation at UEA law-justice-regulation@uea.ac.uk 21 October 2010

  2. Self-regulation in Self-Propelled Nematic Fluids

    E-Print Network [OSTI]

    Aparna Baskaran; M. Cristina Marchetti

    2012-04-15T23:59:59.000Z

    We consider the hydrodynamic theory of an active fluid of self-propelled particles with nematic aligning interactions. This class of materials has polar symmetry at the microscopic level, but forms macrostates of nematic symmetry. We highlight three key features of the dynamics. First, as in polar active fluids, the control parameter for the order-disorder transition, namely the density, is dynamically convected by active currents, resulting in a generic, model independent dynamical self-regulation that destabilizes the uniform nematic state near the mean-field transition. Secondly, curvature driven currents render the system unstable deep in the nematic state, as found previously. Finally, and unique to self-propelled nematics, nematic order induces local polar order that in turn leads to the growth of density fluctuations. We propose this as a possible mechanism for the smectic order of polar clusters seen in numerical simulations.

  3. Scope of the Export Administration Regulations Part 734-page 1 Export Administration Regulations August 2001

    E-Print Network [OSTI]

    Bernstein, Daniel

    Scope of the Export Administration Regulations Part 734-page 1 Export Administration Regulations August 2001 734.1 INTRODUCTION (a) In this part, references to the Export Adminis- tration Regulations (EAR) are references to 15 CFR chapter VII, subchapter C. This part de- scribes the scope of the Export

  4. PA Nutrient Management Regulations: Act 38 of 2005 Summary of Regulations

    E-Print Network [OSTI]

    Guiltinan, Mark

    PA Nutrient Management Regulations: Act 38 of 2005 Summary of Regulations Effective October 1, 2006 are the regulated farms required to do: o Develop and implement approved nutrient management plans o For newly of manure generated on the operation Use actual production records or calculated amount o The nutrient

  5. Engineer Regulation 1110-2-1150

    E-Print Network [OSTI]

    US Army Corps of Engineers

    CECW-EP Engineer Regulation 1110-2-1150 Department of the Army U.S. Army Corps of Engineers Washington, DC 20314-1000 ER 1110-2-1150 31 August 1999 Engineering and Design ENGINEERING AND DESIGN 1110-2-1150 U.S. Army Corps of Engineers CECW-EP Washington, D.C. 20314-1000 Regulation No. 1110

  6. Code of Regulations State of California

    E-Print Network [OSTI]

    , Regulation, and Conservation of Oil and Gas Resources (includes Subchapter 4. Statewide Geothermal DEPARTMENT OF CONSERVATION DEREK CHERNOW, Acting Director #12;Department of Conservation Division of Oil, Gas, and Geothermal Resources Elena M. Miller, State Oil and Gas Supervisor #12;CALIFORNIA CODE OF REGULATIONS

  7. Regulation mechanisms in spatial stochastic development models

    E-Print Network [OSTI]

    Dmitri Finkelshtein; Yuri Kondratiev

    2008-09-04T23:59:59.000Z

    The aim of this paper is to analyze different regulation mechanisms in spatial continuous stochastic development models. We describe the density behavior for models with global mortality and local establishment rates. We prove that the local self-regulation via a competition mechanism (density dependent mortality) may suppress a unbounded growth of the averaged density if the competition kernel is superstable.

  8. RULES AND REGULATIONS ENVIRONMENTAL QUALITY BOARD

    E-Print Network [OSTI]

    Guiltinan, Mark

    Department of Environmental Protection (Department) regulations to the revised Federal regulations may use the AT&T Relay Service, (800) 654-5984 (TDD users) or (800) 654- 5988 (voice users ''appropriate vegetated buffers and setbacks . . . to protect and maintain water quality.'' The final Chapter 91

  9. Master of Science in Development and Regulation

    E-Print Network [OSTI]

    Dennett, Daniel

    Master of Science in Development and Regulation of Medicines and Devices Program Director: Paul I pursue an MS in Development and Regulation of Medicines and Devices? This degree program and Professional Degree Programs 136 Harrison Avenue Boston, Massachusetts 02111 MASTER OF SCIENCE IN Development

  10. NBER WORKING PAPER SERIES REGULATION AND DISTRUST

    E-Print Network [OSTI]

    Boyer, Edmond

    NBER WORKING PAPER SERIES REGULATION AND DISTRUST Philippe Aghion Yann Algan Pierre Cahuc Andrei Massachusetts Avenue Cambridge, MA 02138 January 2009 The authors thank for their very useful comments Alberto,version1-3Apr2014 #12;Regulation and Distrust Philippe Aghion, Yann Algan, Pierre Cahuc, and Andrei

  11. REGULATION OF TELOMERASE BY TELOMERIC PROTEINS

    E-Print Network [OSTI]

    de Lange, Titia

    REGULATION OF TELOMERASE BY TELOMERIC PROTEINS Agata Smogorzewska1 and Titia de Lange2 1 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02115; email: asmogorzewska@partners.org 2, and Sm proteins in budding yeast). Telomerase is regulated in cis by proteins that bind to telomeric DNA

  12. Molecular Cell Negative Regulation of Vps34

    E-Print Network [OSTI]

    Molecular Cell Article Negative Regulation of Vps34 by Cdk Mediated Phosphorylation Tsuyoshi Furuya Hughes Medical Institute Massachusetts Institute of Technology, Cambridge, MA 02139, USA 5Haldeman interacts with Beclin 1, an ortholog of Atg6 in yeast, to regulate the production of PtdIns3P and autophagy

  13. Markets versus Regulation: The Efficiency and Distributional

    E-Print Network [OSTI]

    Markets versus Regulation: The Efficiency and Distributional Impacts of U.S. Climate Policy: Massachusetts Institute of Technology 77 Massachusetts Avenue, E19-411 Cambridge, MA 02139 (USA) Location: globalchange@mit.edu Website: http://globalchange.mit.edu/ #12;1 Markets versus Regulation: The Efficiency

  14. Student Regulations and Procedures Academic Division

    E-Print Network [OSTI]

    Student Regulations and Procedures Academic Division 2007/2008 3 RULES FOR STUDENT CONDUCT fees, award ceremonies and other matters www.mmu.ac.uk/academic/student_regulations.php #12;RULES of Governors in accordance with the following Articles of Government: 7.1.6 Subject to the responsibilities

  15. University Library AMSTERDAM UNIVERSITY LIBRARY USER REGULATIONS

    E-Print Network [OSTI]

    van Rooij, Robert

    University Library AMSTERDAM UNIVERSITY LIBRARY USER REGULATIONS Regulations for the users of the libraries of the University of Amsterdam General 1. The Amsterdam University Library (from hereon: the library) is understood to mean the whole body of faculty libraries and facilities of the Library

  16. Oklahoma State University RULES AND REGULATIONS

    E-Print Network [OSTI]

    Veiga, Pedro Manuel Barbosa

    Oklahoma State University RULES AND REGULATIONS Effective date: 8/1/2013 through 8/31/2014 What page i) Effective May 6, 2013 OrangeRide Bicycle Rental and Repair (see page 52) #12;OKLAHOMA STATE UNIVERSITY PARKING RULES AND REGULATIONS 2014 Department of Parking and Transportation Services Oklahoma

  17. REVIEW ARTICLE Redox regulation of intercellular transport

    E-Print Network [OSTI]

    Jackson, David

    REVIEW ARTICLE Redox regulation of intercellular transport Yoselin Benitez-Alfonso & David Jackson research has suggested the participa- tion of ROS in the regulation of PD transport. The study of several in cell redox homeostasis and PD transport, and the histological detection of hydrogen peroxide

  18. Activins and inhibins: Novel regulators of thymocyte development

    SciTech Connect (OSTI)

    Licona-Limon, Paula; Aleman-Muench, German [Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Escolar s/n, Mexico, DF 04510 (Mexico); Chimal-Monroy, Jesus [Departamento de Medicina Genomica y Toxicologia Ambiental, Instituto de Investigaciones Biomedicas, UNAM, Mexico, DF (Mexico); Macias-Silva, Marina [Departmento de Biologia Celular, Instituto de Fisiologia Celular, UNAM, Mexico, DF (Mexico); Garcia-Zepeda, Eduardo A. [Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Escolar s/n, Mexico, DF 04510 (Mexico); Matzuk, Martin M. [Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (United States); Fortoul, Teresa I. [Departamento de Biologia Celular y Tisular, Facultad de Medicina, UNAM, Mexico, DF (Mexico); Soldevila, Gloria [Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Escolar s/n, Mexico, DF 04510 (Mexico)], E-mail: soldevi@servidor.unam.mx

    2009-04-03T23:59:59.000Z

    Activins and inhibins are members of the transforming growth factor-{beta} superfamily that act on different cell types and regulate a broad range of cellular processes including proliferation, differentiation, and apoptosis. Here, we provide the first evidence that activins and inhibins regulate specific checkpoints during thymocyte development. We demonstrate that both activin A and inhibin A promote the DN3-DN4 transition in vitro, although they differentially control the transition to the DP stage. Whereas activin A induces the accumulation of a CD8{sup +}CD24{sup hi}TCR{beta}{sup lo} intermediate subpopulation, inhibin A promotes the differentiation of DN4 to DP. In addition, both activin A and inhibin A appear to promote CD8{sup +}SP differentiation. Moreover, inhibin {alpha} null mice have delayed in vitro T cell development, showing both a decrease in the DN-DP transition and reduced thymocyte numbers, further supporting a role for inhibins in the control of developmental signals taking place during T cell differentiation in vivo.

  19. CHAPTER 11: CONTROLLING MANAGERS' `BECOMING': THE PRACTICE OF IDENTITY REGULATION

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    1 CHAPTER 11: CONTROLLING MANAGERS' `BECOMING': THE PRACTICE OF IDENTITY REGULATION Stphan Pez regulation. My focus is on how identity regulation is performed through individuals' concrete actions regulation discourses are performed through micro- practices showing that identity regulation is far from

  20. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: April 29, 2008 REGULATION TITLE approval FAU Regulation 4.013, Exceptional Circumstance Withdrawals. This regulation outlines the process, and staff when it is appropriate to use this regulation. The committee, composed of representatives from all

  1. NOTICE OF PROPOSED REGULATION AMENDMENT Date: November 8, 2011

    E-Print Network [OSTI]

    Richardson, Martin C.

    REGULATION AMENDMENT: Dr. James Fenton, Director, Florida Solar Energy Center COMMENTS CONCERNING.: Solar Thermal Collector and PV Module Certification UCF-8.008 SUMMARY OF REGULATION: This regulation-mail: regulations@mail.ucf.edu FULL TEXT OF THE PROPOSED REGULATION AMENDMENT: UCF-8.008 Solar Thermal Collector

  2. Geometrically induced magnetic catalysis and critical dimensions

    E-Print Network [OSTI]

    Antonino Flachi; Kenji Fukushima; Vincenzo Vitagliano

    2015-02-21T23:59:59.000Z

    We discuss the combined effect of magnetic fields and geometry in interacting fermionic systems. At leading order in the heat-kernel expansion, the infrared singularity (that in flat space leads to the magnetic catalysis) is regulated by the chiral gap effect and the catalysis is deactivated by effect of the curvature. We discover that an infrared singularity may reappear from higher-order terms in the heat kernel expansion leading to a novel form of geometrically induced magnetic catalysis (absent in flat space). The dynamical mass squared is then modified not only due to the chiral gap effect by an amount proportional to the curvature, but also by a magnetic shift $\\propto (4-D)eB$ where $D$ represents the number of space-time dimensions. We argue that $D=4$ is a critical dimension across which the behaviour of the magnetic shift changes qualitatively.

  3. Geometrically induced magnetic catalysis and critical dimensions

    E-Print Network [OSTI]

    Flachi, Antonino; Vitagliano, Vincenzo

    2015-01-01T23:59:59.000Z

    We discuss the combined effect of magnetic fields and geometry in interacting fermionic systems. At leading order in the heat-kernel expansion, the infrared singularity (that in flat space leads to the magnetic catalysis) is regulated by the chiral gap effect and the catalysis is deactivated by effect of the curvature. We discover that an infrared singularity may reappear from higher-order terms in the heat kernel expansion leading to a novel form of geometrically induced magnetic catalysis (absent in flat space). The dynamical mass squared is then modified not only due to the chiral gap effect by an amount proportional to the curvature, but also by a magnetic shift $\\propto (4-D)eB$ where $D$ represents the number of space-time dimensions. We argue that $D=4$ is a critical dimension across which the behaviour of the magnetic shift changes qualitatively.

  4. Geometrically induced magnetic catalysis and critical dimensions

    E-Print Network [OSTI]

    Antonino Flachi; Kenji Fukushima; Vincenzo Vitagliano

    2015-04-27T23:59:59.000Z

    We discuss the combined effect of magnetic fields and geometry in interacting fermionic systems. At leading order in the heat-kernel expansion, the infrared singularity (that in flat space leads to the magnetic catalysis) is regulated by the chiral gap effect, and the catalysis is deactivated by the effect of the scalar curvature. We discover that an infrared singularity is found in higher-order terms that mix the magnetic field with curvature, and these lead to a novel form of geometrically induced magnetic catalysis. The dynamical mass squared is then modified not only due to the chiral gap effect by an amount proportional to the curvature, but also by a magnetic shift $\\propto (4-D)eB$, where $D$ represents the number of space-time dimensions. We argue that $D=4$ is a critical dimension across which the behavior of the magnetic shift changes qualitatively.

  5. ERK2: a logical AND gate critical for drug-induced plasticity? Truncated title

    E-Print Network [OSTI]

    1 Title: ERK2: a logical AND gate critical for drug-induced plasticity? Truncated title: ERK2 signal-regulated kinase (ERK) plays an important role in the underlying molecular mechanisms. ERK. Blockade of ERK activation prevents long- lasting behavioral changes, including psychomotor sensitization

  6. Regulation of Notch by Itch AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Regulation of Notch by Itch 1 AIP4/Itch Regulates Notch Receptor Degradation in the AbsenceS ONE 3, 7 (2008) e2735" #12;Regulation of Notch by Itch 2 ABSTRACT Background. The regulation of Notch of ubiquitin-ligases, has been described as a negative regulator of Notch signaling, acting on the post

  7. Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes

    E-Print Network [OSTI]

    Babu, M. Madan

    Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes Sarath. Although it is known that eukaryotic transcriptional regulation is complex and requires an intricate-order organization of genes across and within chromosomes that is constrained by transcriptional regulation

  8. Self-Regulation as Two-Stage Rent-Seeking

    E-Print Network [OSTI]

    von Wangemheim, Georg

    2009-01-01T23:59:59.000Z

    interests and self-regulation; an economic approach (pp.Jose; Llobet, Gerard (2007): Regulation, Corporate SocialA Signaling Motive for Self-Regulation in the Shadow of

  9. Emotion Regulation and Attachment: Unpacking Two Constructs and Their Association

    E-Print Network [OSTI]

    Waters, Sara F.; Virmani, Elita A.; Thompson, Ross A.; Meyer, Sara; Raikes, H. Abigail; Jochem, Rachel

    2010-01-01T23:59:59.000Z

    The socialization of emotion regulation in the family. In J.Handbook of emotion regulation (pp. 249268). New York:J. L. (2002). Anger regulation in disadvantaged preschool

  10. Business or Pleasure? Utilitarian Versus Hedonic Considerations in Emotion Regulation

    E-Print Network [OSTI]

    Gross, James J.

    Business or Pleasure? Utilitarian Versus Hedonic Considerations in Emotion Regulation Maya Tamir, it is typically assumed that individuals regulate emotions to obtain hedonic, rather than utilitarian, benefits predicted motives for emotion regulation. When anticipating a threatening task, participants who viewed

  11. Emotion Regulation in Children and Adolescents With Autism Spectrum Disorder

    E-Print Network [OSTI]

    Gross, James J.

    Emotion Regulation in Children and Adolescents With Autism Spectrum Disorder Andrea C. Samson group- matched typically developing (TD) controls completed a Reactivity and Regulation Situation Task. This task assesses emotional reactivity and spontaneous use of emotion regulation strategies (problem

  12. Interacting models of cooperative gene regulation Debopriya Das*, Nilanjana Banerjee*

    E-Print Network [OSTI]

    Interacting models of cooperative gene regulation Debopriya Das*, Nilanjana Banerjee* , and Michael, especially mammals, where cooperative control of gene regulation is absolutely essential. cooperativity control in gene regulation networks. It requires cooperative binding of multiple transcription factors

  13. Regulation and Moral Hazard in Forest Concessions in Brazil

    E-Print Network [OSTI]

    Balbinotto Neto, Gicomo; Tillmann, Eduardo A; Ratnieks, Ianes

    2012-01-01T23:59:59.000Z

    E. M. Designing incentive regulation. Review of IndustrialAgent approach for incentive regulation can be defined,the theory of incentive regulation as a tool to solve the

  14. Shrouded inducer pump

    DOE Patents [OSTI]

    Meng, S.Y.

    1989-08-08T23:59:59.000Z

    An improvement in a pump is described including a shrouded inducer, the improvement comprising first and second sealing means which cooperate with a first vortex cell and a series of secondary vortex cells to remove any tangential velocity components from the recirculation flow. 3 figs.

  15. The procedures and regulation pertaining to the internal examiner First: Aim of the regulation pertaining to the internal examiner

    E-Print Network [OSTI]

    The procedures and regulation pertaining to the internal examiner First: Aim of the regulation pertaining to the internal examiner: The aims of the internal examiner regulation is: 1- To ensure meticulous

  16. Air Pollution Control Regulations: No. 13 - Particulate Emissions...

    Broader source: Energy.gov (indexed) [DOE]

    Environmental Regulations Provider Department of Environmental Management The purpose of this regulation is to limit emissions of particulate matter from fossil fuel fired and...

  17. Technical Demonstration of 2010 Emissions Regulations over Transient...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Demonstration of 2010 Emissions Regulations over Transient Operation Technical Demonstration of 2010 Emissions Regulations over Transient Operation Presentation given at DEER 2006,...

  18. POLICY FLASH 2015-22 - Federal Acquisition Regulation Class Deviation...

    Energy Savers [EERE]

    POLICY FLASH 2015-22 - Federal Acquisition Regulation Class Deviation POLICY FLASH 2015-22 - Federal Acquisition Regulation Class Deviation DATE: May 8, 2015 TO: Procurement...

  19. EO 13211: Regulations That Significantly Affect Energy Supply...

    Energy Savers [EERE]

    1: Regulations That Significantly Affect Energy Supply, Distribution, or Use EO 13211: Regulations That Significantly Affect Energy Supply, Distribution, or Use I am requiring that...

  20. Air Emissions Operating Permit Regulations for the Purposes of...

    Broader source: Energy.gov (indexed) [DOE]

    Environmental Regulations Provider Department of Environmental Quality The Air Emissions Operating Permit Regulations for the Purpose of Title V of the Federal Clean Air Act...

  1. The Nuclear Installations (Dangerous Occurrences )(Amendment) Regulations 1963

    E-Print Network [OSTI]

    Wood, Richard; Noble, Michael

    1963-01-01T23:59:59.000Z

    STATUTORY INSTRUMENTS 1963 No. 1358 ATOMIC ENERGY AND RADIOACTIVE SUBSTANCES LICENSING AND REGULATION OF SITES The Nuclear Installations (Dangerous Occurrences) (Amendment) Regulations 1963...

  2. Update on Diesel Exhaust Emission Control Technology and Regulations...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Control Technology and Regulations Update on Diesel Exhaust Emission Control Technology and Regulations 2004 Diesel Engine Emissions Reduction (DEER) Conference Presentation:...

  3. Guide to Federal Regulation of Sales of Imported Electricity...

    Broader source: Energy.gov (indexed) [DOE]

    Group on January 2005 Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States More Documents & Publications North America: Regulation...

  4. EA-1631: Beacon Power Corporation Frequency Regulation Facility...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1: Beacon Power Corporation Frequency Regulation Facility in Stephentown, NY EA-1631: Beacon Power Corporation Frequency Regulation Facility in Stephentown, NY February 2, 2009...

  5. Contacts for the Deputy General Counsel for Litigation, Regulation...

    Energy Savers [EERE]

    Litigation, Regulation and Enforcement (GC-30) Contacts for the Deputy General Counsel for Litigation, Regulation and Enforcement (GC-30) Anne Harkavy, Deputy General Counsel for...

  6. Transport Regulation from Theory to Practice: General Observations...

    Open Energy Info (EERE)

    Transport Regulation from Theory to Practice: General Observations and a Case Study Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Transport Regulation from Theory to...

  7. Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus

    SciTech Connect (OSTI)

    Banerjee, Chaitali [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Goswami, Ramansu [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Centre for Environmental Studies, Visva-Bharati University, Santiniketan 731 235 (India); Datta, Soma [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Rajagopal, R. [Gut Biology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India); Mazumder, Shibnath, E-mail: shibnath1@yahoo.co.in [Immunobiology Laboratory, Department of Zoology, University of Delhi, Delhi 110 007 (India)

    2011-10-01T23:59:59.000Z

    We had earlier shown that exposure to arsenic (0.50 {mu}M) caused caspase-3 mediated head kidney macrophage (HKM) apoptosis involving the p38-JNK pathway in Clarias batrachus. Here we examined the roles of calcium (Ca{sup 2+}) and extra-cellular signal-regulated protein kinase (ERK), the other member of MAPK-pathway on arsenic-induced HKM apoptosis. Arsenic-induced HKM apoptosis involved increased expression of ERK and calpain-2. Nifedipine, verapamil and EGTA pre-treatment inhibited the activation of calpain-2, ERK and reduced arsenic-induced HKM apoptosis as evidenced from reduced caspase-3 activity, Annexin V-FITC-propidium iodide and Hoechst 33342 staining. Pre-incubation with ERK inhibitor U 0126 inhibited the activation of calpain-2 and interfered with arsenic-induced HKM apoptosis. Additionally, pre-incubation with calpain-2 inhibitor also interfered with the activation of ERK and inhibited arsenic-induced HKM apoptosis. The NADPH oxidase inhibitor apocynin and diphenyleneiodonium chloride also inhibited ERK activation indicating activation of ERK in arsenic-exposed HKM also depends on signals from NADPH oxidase pathway. Our study demonstrates the critical role of Ca{sup 2+} homeostasis on arsenic-induced HKM apoptosis. We suggest that arsenic-induced alteration in intracellular Ca{sup 2+} levels initiates pro-apoptotic ERK and calpain-2; the two pathways influence each other positively and induce caspase-3 mediated HKM apoptosis. Besides, our study also indicates the role of ROS in the activation of ERK pathway in arsenic-induced HKM apoptosis in C. batrachus. - Highlights: > Altered Ca{sup 2+} homeostasis leads to arsenic-induced HKM apoptosis. > Calpain-2 plays a critical role in the process. > ERK is pro-apoptotic in arsenic-induced HKM apoptosis. > Arsenic-induced HKM apoptosis involves cross talk between calpain-2 and ERK.

  8. NONPROLIFERATION PROMOTED BY INDUSTRY SELF-REGULATION

    E-Print Network [OSTI]

    and institutional procedures and accountability. This analysis is based on reviewing several case studies of other industries that have pursued a self-regulation approach.2 These case studies were dissected to understand

  9. Essays on entry regulation, institutions, and development

    E-Print Network [OSTI]

    Bruhn, Miriam

    2007-01-01T23:59:59.000Z

    This thesis is a collection of three essays on entry regulation, institutions, and development.Chapter 1 examines the effect of a business registration reform in Mexico on economic activity. This reform made registration ...

  10. The effect of praying on emotion regulation

    E-Print Network [OSTI]

    Kossurok, Anke

    2012-11-28T23:59:59.000Z

    , and is associated with experiencing a greater purpose in life. Similarly, the present study examined whether praying affects peoples ability to regulate emotions. Participants were randomly assigned to a prayer, coping and control group. They completed the Emotion...

  11. State Natural Gas Regulation Act (Nebraska)

    Broader source: Energy.gov [DOE]

    This act gives the Nebraska Public Service Commission authority to regulate natural gas utilities and pipelines within the state, except as provided for in the Nebraska Natural Gas Pipeline Safety...

  12. Regulation of geothermal energy development in Colorado

    SciTech Connect (OSTI)

    Coe, B.A.; Forman, N.A.

    1980-01-01T23:59:59.000Z

    The regulatory system is presented in a format to help guide geothermal energy development. State, local, and federal agencies, legislation, and regulations are presented. Information sources are listed. (MHR)

  13. Comprehensive Everglades Restoration Plan Regulation Act (Florida)

    Broader source: Energy.gov [DOE]

    This Act enacts the Comprehensive Everglades Restoration Plan, which is a joint state and federal effort to provide for the conservation of the Everglades region. The plan regulates land and water...

  14. Hazardous Waste Management Standards and Regulations (Kansas)

    Broader source: Energy.gov [DOE]

    This act states the standards and regulations for the management of hazardous waste. No person shall construct, modify or operate a hazardous waste facility or otherwise dispose of hazardous waste...

  15. Regulating new construction in historic areas

    E-Print Network [OSTI]

    Sellers-Garcia, Oliver

    2006-01-01T23:59:59.000Z

    This study is an examination of how the restrictiveness of different design regulations impacts the process of new construction in historic areas. The North End, South End, and Back Bay neighborhoods of Boston were identified ...

  16. Micah Allred Psychology, Lottery Marketing, and Regulation

    E-Print Network [OSTI]

    Jarvis, Tyler J.

    Micah Allred HonP 342R Dr. Jarvis Psychology, Lottery Marketing, and Regulation Marketing is below, and does not include their payouts [11]. In an advertising campaign in 1996, the Massachusetts

  17. Is Conservation a Legitimate Goal of Regulation?

    E-Print Network [OSTI]

    Goble, G. L.

    1984-01-01T23:59:59.000Z

    Conservation of energy is a frequently cited goal of utility rate regulation. Implementing this goal through modification of consumer behavior has been achieved with varying degrees of success through rate design, incentive programs, direct load...

  18. Module 9: Acts, Codes, Regulations and Guidelines

    Broader source: Energy.gov [DOE]

    This course covers the mandating of alternative fuel vehicles in the US, the codes, regulations, and guidelines concerning the use of hydrogen, where to look for additional information on hydrogen standards

  19. Issues paper on radiation site cleanup regulations

    SciTech Connect (OSTI)

    Not Available

    1993-09-01T23:59:59.000Z

    EPA prepared the document to present issues, approaches, and preliminary analyses related to its development of radiation site cleanup regulations. It focuses exclusively on issues and approaches related to developing cleanup regulations; it does not address issues specific to waste management regulations, which will be addressed in a separate document. The first three chapters discuss Significant Issues, Regulatory Approaches, and Summary and Next Steps. Appendix A presents background information on radioactive waste and provides additional details of EPA coordination of its rulemaking effort. Appendix B discusses statutory authorities upon which EPA may base its cleanup regulations. Appendix C is a copy of the EPA/NRC MOU. Appendix D discusses the issues raised in NRC's Enhanced Participatory Rulemaking on Radiological Criteria for Decommissioning, in which EPA participated. Appendix E is a list of acronyms, and Appendix F is a glossary of terms used throughout the document.

  20. Use of geostatistic techniques to describe a reservoir to be submitted into a secondary recovery process field case: {open_quotes}Eocene B-Inferior/VLG-3659, Ceuta, Venezuela{close_quotes}

    SciTech Connect (OSTI)

    Hernandez, T.; Poquioma, W. [Maraven, S.A., Caracas (Venezuela)

    1997-08-01T23:59:59.000Z

    This study presents the results of an integrated reservoir study of the Eocene B-Inferior/VLG-3659, Area 7, Ceuta filed. This field located in the Maracaibo Lake in the western side of Venezuela. The objective was to evaluating the feasibility to implement a secondary recovery project by means of water flooding. Core information was used for this study (194 ft), PVT analysis, RFI, build-up and statistic`s pressure analysis, modem logs and production history data. Using geostatistical techniques (Kriging) it was defined a low uncertainty geological model that was validated by means of a black oil simulator (Eclipse). The results showed a good comparison of historical pressure of the reservoir against those obtained from the model, without the need of {open_quotes}history matching{close_quotes}. It means without modifying neither the initial rock properties nor reservoir fluids. The results of this study recommended drilling in two new locations, also the reactivation of four producing wells and water flooding under peripherical array by means of four injection wells, with the recovery of an additional 30.2 MMSTB. The economical evaluation shows an internal return rate of 31.4%.

  1. Allostery through protein-induced DNA bubbles

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Traverso, Joseph J.; Manoranjan, Valipuram S.; Bishop, A. R.; Rasmussen, Kim .; Voulgarakis, Nikolaos K.

    2015-03-12T23:59:59.000Z

    Allostery through DNA is increasingly recognized as an important modulator of DNA functions. Here, we show that the coalescence of protein-induced DNA bubbles can mediate allosteric interactions that drive protein aggregation. We propose that such allostery may regulate DNA's flexibility and the assembly of the transcription machinery. Mitochondrial transcription factor A (TFAM), a dual-function protein involved in mitochondrial DNA (mtDNA) packaging and transcription initiation, is an ideal candidate to test such a hypothesis owing to its ability to locally unwind the double helix. Numerical simulations demonstrate that the coalescence of TFAM-induced bubbles can explain experimentally observed TFAM oligomerization. The resultingmoremelted DNA segment, approximately 10 base pairs long, around the joints of the oligomers act as flexible hinges, which explains the efficiency of TFAM in compacting DNA. Since mitochondrial polymerase (mitoRNAP) is involved in melting the transcription bubble, TFAM may use the same allosteric interaction to both recruit mitoRNAP and initiate transcription.less

  2. Regulation of the genes involved in nitrification.

    SciTech Connect (OSTI)

    Arp, D.J.; Sayavedra-Soto, L.A.

    2003-08-14T23:59:59.000Z

    OAK-B135 This project focuses on the characterization of the regulation of the genes involved in nitrification in the bacterium Nitrosomonas europaea. The key genes in the nitrification pathway, amo and hao, are present in multiple copies in the genome. The promoters for these genes were identified and characterized. It was shown that there were some differences in the transcriptional regulation of the copies of these genes.

  3. REGULATIONS ON PHOTOVOLTAIC MODULE DISPOSAL AND RECYCLING.

    SciTech Connect (OSTI)

    FTHENAKIS,V.

    2001-01-29T23:59:59.000Z

    Environmental regulations can have a significant impact on product use, disposal, and recycling. This report summarizes the basic aspects of current federal, state and international regulations which apply to end-of-life photovoltaic (PV) modules and PV manufacturing scrap destined for disposal or recycling. It also discusses proposed regulations for electronics that may set the ground of what is to be expected in this area in the near future. In the US, several states have started programs to support the recycling of electronic equipment, and materials destined for recycling often are excepted from solid waste regulations during the collection, transfer, storage and processing stages. California regulations are described separately because they are different from those of most other states. International agreements on the movement of waste between different countries may pose barriers to cross-border shipments. Currently waste moves freely among country members of the Organization of Economic Cooperation and Development (OECD), and between the US and the four countries with which the US has bilateral agreements. However, it is expected, that the US will adopt the rules of the Basel Convention (an agreement which currently applies to 128 countries but not the US) and that the Convection's waste classification system will influence the current OECD waste-handling system. Some countries adopting the Basel Convention consider end-of-life electronics to be hazardous waste, whereas the OECD countries consider them to be non-hazardous. Also, waste management regulations potentially affecting electronics in Germany and Japan are mentioned in this report.

  4. Moving from self-regulation to external regulation of Department of Energy facilities

    SciTech Connect (OSTI)

    Wishau, R.J.; Dawson, J.; Lee, D.W.

    1999-03-01T23:59:59.000Z

    This paper discusses the initiative to transfer the regulation of Department of Energy (DOE) nuclear facilities to the US Nuclear Regulatory Commission (NRC). The paper gives an overview of some of the major technical, policy and legal issues that accompany this initiative. The paper focuses on specific issues and how they may be affected by external regulation of occupational radiation protection at DOE facilities. Differences between the NRC and the DOE approach to regulating nuclear safety are compared and contrasted. Some projected impacts from this transition are examined. Finally, recommendations are provided that may enhance the transition, increasing the likelihood of successful external NRC regulation.

  5. Smart Grid Newsletter ? The Regulators Role in Grid Modernization...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Title: "The Regulator's Role in Grid Modernization" Sponsor: The Modern Grid Strategy is a DOE-funded project conducted by the National Energy Technology Laboratory Leadership from...

  6. Laser-Induced Breakdown Spectroscopy

    E-Print Network [OSTI]

    Nizkorodov, Sergey

    LIBS-1 Laser-Induced Breakdown Spectroscopy LIBS ANALYSIS OF METAL SURFACES Last updated: June 17, 2014 #12;LIBS-2 LaserInduced Breakdown Spectroscopy (LIBS) LIBS ANALYSIS OF METAL SURFACES of species at a distance or in hardtoreach or hazardous environments. LaserInduced Breakdown Spectroscopy

  7. Environment induced incoherent controllability

    E-Print Network [OSTI]

    Raffaele Romano; Domenico D'Alessandro

    2005-11-08T23:59:59.000Z

    We prove that the environment induced entanglement between two non interacting, two-dimensional quantum systems S and P can be used to control the dynamics of S by means of the initial state of P. Using a simple, exactly solvable model, we show that both accessibility and controllability of S can be achieved under suitable conditions on the interaction of S and P with the environment.

  8. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: October 9, 2007 REGULATION Board of Governors ("BOG") promulgated new regulations that relate to new program termination (6C-8.012, Academic Program Termination). The Regulations require that each university board of trustees adopt

  9. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: October 13, 2011 REGULATION-support organizations (DSOs) are governed by Florida Statute s. 1004.28 and Board of Governors Regulation 6 conditions, controls and requirements as each board deems appropriate for oversight. The proposed regulation

  10. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: February 11, 2011 REGULATION.009). SUMMARY: The University administration seeks approval to amend FAU Regulation 4.009, Major Medical Insurance Requirements for Foreign Students. This proposed amended regulation, renamed Health Insurance

  11. Vohs.indb 407 The Effects of Self-Regulation

    E-Print Network [OSTI]

    Reber, Paul J.

    Vohs.indb 407 The Effects of Self-Regulation on Social Relationships GRAINNE M. FITZSIMONS ELI J consequences of self-regulation? A large body of research within personality, organizational, and social psychology has demonstrated that self-regulation has significant consequences for the individual. Good self-regulators

  12. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: October 9, 2007 REGULATION: At its March 2007 meeting, the Florida Board of Governors ("BOG") promulgated new regulations that relate to new program authorization (6C-8.011, Academic Program Authorization). The Regulations require

  13. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: April 29, 2008 REGULATION TITLE for the proposed FAU Regulation 4.014, Medical Advisory Committee. This committee will advise and make to themselves or others in the University. Approval of this proposed regulation allows the University to have

  14. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: June 18, 2009 REGULATION TITLE of Governors is required to promulgate a regulation to implement the Textbook Affordability Act of 2008. The BOG promulgated Regulation 8.003 on March 26, 2009, which requires each Board of Trustees

  15. CAPTURE OR CONTRACT?: THE EARLY YEARS OF ELECTRIC UTILITY REGULATION

    E-Print Network [OSTI]

    Lyon, Thomas P.

    CAPTURE OR CONTRACT?: THE EARLY YEARS OF ELECTRIC UTILITY REGULATION Thomas P. Lyon Nathan Wilson prices rose in states that adopted state regulation before 1917, suggesting that regulators were "captured" by the interests of the regulated electric utilities. An alternative explanation is that state

  16. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    -1- FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: April 5, 2010 REGULATION of Academic Affairs seeks approval of the proposed FAU Regulation 4.002, Student Academic Grievance Procedures for Grade Reviews. Approval is dependent on the repeal of the current FAU Regulation 4.002 and the approval

  17. Regulation and Execution of Meiosis in Drosophh Males

    E-Print Network [OSTI]

    9 Regulation and Execution of Meiosis in Drosophh Males lean Maines and Steven Wasserm. Identification of Male Meiotic Mutant\\ IT. Regulation of the Meiotic Cell Divisions A. Entry into Meiosis B. Regulation of the Cell Cycle Machinery C. Coordination of Meio\\i\\ with Diflerentiation D. Regulation

  18. Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease

    E-Print Network [OSTI]

    Levenson, Robert W.

    Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease Madeleine instructed and spontaneous emotion regulation in patients with frontotemporal lobar degeneration (FTLD, N 32) unwarned without instructions to down-regulate, (b) warned without instructions to down-regulate, and (c

  19. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: April 14, 2011 REGULATION TITLE College of Medicine seeks approval of the proposed FAU Regulation 9.001, Faculty Practice Plan and administration of the Faculty Practice Plan. FULL TEXT OF THE REGULATION: The full text of the proposed

  20. FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION

    E-Print Network [OSTI]

    Richman, Fred

    FLORIDA ATLANTIC UNIVERSITY NOTICE OF PROPOSED NEW REGULATION Date: April 16, 2009 REGULATION TITLE AND NUMBER: Institutes and Centers (2.006). SUMMARY: Board of Governors Regulation 10.015(3), University with Board of Governors criteria. Proposed Regulation 2.006 responds to this requirement and provides

  1. Modeling and Analysis of Heterogeneous Regulation in Biological Networks.

    E-Print Network [OSTI]

    Shamir, Ron

    Modeling and Analysis of Heterogeneous Regulation in Biological Networks. Irit Gat-Viks Amos Tanay of an integrative approach to the modeling and learning of regulation. In this work we study steady state behavior (metabolites may regulate transcription, enzymes may regulate metabolic reactions). We show how such models can

  2. Deviational analyses for validating regulations on real systems

    E-Print Network [OSTI]

    Kelly, Tim

    Deviational analyses for validating regulations on real systems Fiona Polack, Thitima Srivatanakul to the validation of reg- ulations, in the sense of their application of regulations to real systems. Keyword: deviational analysis, dependability, regulation validation 1 Background Regulations are intended to control

  3. NOTICE OF PROPOSED REGULATION AMENDMENT Date: November 8, 2011

    E-Print Network [OSTI]

    Richardson, Martin C.

    PROPOSED REGULATION AMENDMENT: Dr. James Fenton, Director, Florida Solar Energy Center COMMENTS CONCERNING.: Solar Thermal and Photovoltaic System Standards UCF-8.010 and Certification SUMMARY OF REGULATION-mail: regulations@mail.ucf.edu FULL TEXT OF THE PROPOSED REGULATION AMENDMENT: UCF-8.010 Solar Thermal

  4. NOTICE OF PROPOSED REGULATION AMENDMENT Date: November 8, 2011

    E-Print Network [OSTI]

    Richardson, Martin C.

    .: Florida Solar Energy Center Operations UCF-8.006 SUMMARY OF REGULATION: This regulation is an updated-mail: regulations@mail.ucf.edu FULL TEXT OF THE PROPOSED REGULATION AMENDMENT: UCF-8.006 Florida Solar Energy Center AMENDMENT: Dr. James Fenton, Director, Florida Solar Energy Center COMMENTS CONCERNING THE PROPOSED

  5. May 22, 2002 Advanced Workshop in Regulation and Competition

    E-Print Network [OSTI]

    Lin, Xiaodong

    %Restructuring &Strategies under Competition and Deregulation %Incentive Regulation %Market Innovation Who should

  6. Advanced Workshop in Regulation and Competition Annual Western Conference

    E-Print Network [OSTI]

    Lin, Xiaodong

    and Deregulation %Incentive Regulation %Auctions Who should attend: &Industry Economists %Marketing and Regulatory

  7. Rules and Regulations for Hazardous Waste Management (Rhode Island)

    Broader source: Energy.gov [DOE]

    These regulations establish permitting and operational requirements for hazardous waste facilities. They are designed to minimize...

  8. NOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005

    E-Print Network [OSTI]

    Wu, Shin-Tson

    .: Florida Solar Energy Center Operations 6C7-8.001 SUMMARY OF REGULATION AMENDMENT: This regulation is revised to update the location of the Florida Solar Energy Center. This regulation is amended also of Florida Solar Energy Center COMMENTS CONCERNING THE PROPOSED REGULATION AMENDMENT SHOULD BE SUBMITTED

  9. NOTICE OF PROPOSED REGULATION AMENDMENT Date: April 15, 2009

    E-Print Network [OSTI]

    Wu, Shin-Tson

    .: Florida Solar Energy Center Operations UCF-8.001 SUMMARY OF REGULATION AMENDMENT: The regulation Director, Florida Solar Energy Center COMMENTS CONCERNING THE PROPOSED REGULATION AMENDMENT SHOULD TEXT OF THE PROPOSED REGULATION AMENDMENT: UCF6C7-8.001 Florida Solar Energy Center Operations. (1

  10. IKK{epsilon} modulates RSV-induced NF-{kappa}B-dependent gene transcription

    SciTech Connect (OSTI)

    Bao Xiaoyong; Indukuri, Hemalatha; Liu Tianshuang; Liao Suiling [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Tian, Bing; Brasier, Allan R. [Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX (United States); Garofalo, Roberto P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States); Casola, Antonella, E-mail: ancasola@utmb.ed [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States)

    2010-12-20T23:59:59.000Z

    Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-{kappa}B (NF-{kappa}B). In this study we have investigated the role of the non canonical I{kappa}B kinase (IKK){epsilon} in modulating RSV-induced NF-{kappa}B activation. Our results show that inhibition of IKK{epsilon} activation results in significant impairment of viral-induced NF-{kappa}B-dependent gene expression, through a reduction in NF-{kappa}B transcriptional activity, without changes in nuclear translocation or DNA-binding activity. Absence of IKK{epsilon} results in a significant decrease of RSV-induced NF-{kappa}B phosphorylation on serine 536, a post-translational modification important for RSV-induced NF-{kappa}B-dependent gene expression, known to regulate NF-{kappa}B transcriptional activity without affecting nuclear translocation. This study identifies a novel mechanism by which IKK{epsilon} regulates viral-induced cellular signaling.

  11. Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation

    SciTech Connect (OSTI)

    Reed, J.C.; Tsujimoto, Y.; Alpers, J.D.; Croce, C.M.; Nowell, P.C.

    1987-06-05T23:59:59.000Z

    The bcl-2 and c-myc proto-oncogenes are brought into juxtaposition with the immuno-globulin heavy chain locus in particular B-cell lymphomas, resulting in high levels of constitutive accumulation of their messenger RNAs. Precisely how the products of the bcl-2 and c-myc genes contribute to tumorigenesis is unknown, but observations that c-myc expression is rapidly induced in nonneoplastic lymphocytes upon stimulation of proliferation raise the possibility that this proto-oncogene is involved in the control of normal cellular growth. In addition to c-myc, the bcl-2 proto-oncogene also was expressed in normal human B and T lymphocytes after stimulation with appropriate mitogens. Comparison of the regulation of the expression of these proto-oncogenes demonstrated marked differences and provided evidence that, in contrast to c-myc, levels of bcl-2 messenger RNA are regulated primarily though transcriptional mechanisms. 10 references, 3 figures.

  12. Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent

    SciTech Connect (OSTI)

    Majkova, Zuzana [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536-0200 (United States); Smart, Eric [Department of Pediatrics, University of Kentucky, Lexington, KY 40536-0200 (United States); Toborek, Michal [Departmet of Neurosurgery, University of Kentucky, Lexington, KY 40536-0200 (United States); Hennig, Bernhard [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536-0200 (United States); Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40536-0200 (United States)], E-mail: bhennig@email.uky.edu

    2009-05-15T23:59:59.000Z

    Atherosclerosis, the primary cause of heart disease and stroke is initiated in the vascular endothelium, and risk factors for its development include environmental exposure to persistent organic pollutants. Caveolae are membrane microdomains involved in regulation of many signaling pathways, and in particular in endothelial cells. We tested the hypothesis that intact caveolae are required for coplanar PCB77-induced up-regulation of monocyte chemoattractant protein-1 (MCP-1), an endothelium-derived chemokine that attracts monocytes into sub-endothelial space in early stages of the atherosclerosis development. Atherosclerosis-prone LDL-R{sup -/-} mice (control) or caveolin-1{sup -/-}/LDL-R{sup -/-} mice were treated with PCB77. PCB77 induced aortic mRNA expression and plasma protein levels of MCP-1 in control, but not caveolin-1{sup -/-}/LDL-R{sup -/-} mice. To study the mechanism of this effect, primary endothelial cells were used. PCB77 increased MCP-1 levels in endothelial cells in a time- and concentration-dependent manner. This effect was abolished by caveolin-1 silencing using siRNA. Also, MCP-1 up-regulation by PCB77 was prevented by inhibiting p38 and c-Jun N-terminal kinase (JNK), but not ERK1/2, suggesting regulatory functions via p38 and JNK MAPK pathways. Finally, pre-treatment of endothelial cells with the aryl hydrocarbon receptor (AhR) inhibitor {alpha}-naphthoflavone ({alpha}-NF) partially blocked MCP-1 up-regulation. Thus, our data demonstrate that coplanar PCB77 can induce MCP-1 expression by endothelial cells and that this effect is mediated by AhR, as well as p 38 and JNK MAPK pathways. Intact caveolae are required for these processes both in vivo and in vitro. This further supports a key role for caveolae in vascular inflammation induced by persistent organic pollutants.

  13. I kappa B Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity

    E-Print Network [OSTI]

    Christoffel, Daniel J.

    The neurobiological underpinnings of mood and anxiety disorders have been linked to the nucleus accumbens (NAc), a region important in processing the rewarding and emotional salience of stimuli. Using chronic social defeat ...

  14. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival

    E-Print Network [OSTI]

    Brown, Myles

    for post-menopausal osteoporosis (Sambrook and Cooper, 2006). Estrogen and ERs are important for bone and Musculoskeletal Biology, Wyeth Research, Collegeville, PA, USA Estrogen deficiency in menopause is a major cause of osteoporosis in women. Estrogen acts to maintain the appropriate ratio between bone-forming osteoblasts

  15. A DNA Damage-Induced, SOS-Independent Checkpoint Regulates Cell Division in Caulobacter crescentus

    E-Print Network [OSTI]

    Modell, Joshua W.

    Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the ...

  16. RESEARCH ARTICLE Effectiveness of pulse flows in a regulated river for inducing

    E-Print Network [OSTI]

    Hinch, Scott G.

    ) in a reach of the Puntledge River where water is diverted for power generation, resulting in stable low flows (i.e., turbine out flows), and/or the presence of non-optimal environmental conditions (i.e., cold, Courtenay, BC V9N 2Z5, Canada B. Mossop BC Hydro, 6911 Southpoint Drive, Burnaby, BC V3N 4X8, Canada S. G

  17. Method for inducing hypothermia

    DOE Patents [OSTI]

    Becker, Lance B.; Hoek, Terry Vanden; Kasza, Kenneth E.

    2005-11-08T23:59:59.000Z

    Systems for phase-change particulate slurry cooling equipment and methods to induce hypothermia in a patient through internal and external cooling are provided. Subcutaneous, intravascular, intraperitoneal, gastrointestinal, and lung methods of cooling are carried out using saline ice slurries or other phase-change slurries compatible with human tissue. Perfluorocarbon slurries or other slurry types compatible with human tissue are used for pulmonary cooling. And traditional external cooling methods are improved by utilizing phase-change slurry materials in cooling caps and torso blankets.

  18. Method for inducing hypothermia

    DOE Patents [OSTI]

    Becker, Lance B. (Chicago, IL); Hoek, Terry Vanden (Chicago, IL); Kasza, Kenneth E. (Palos Park, IL)

    2003-04-15T23:59:59.000Z

    Systems for phase-change particulate slurry cooling equipment and methods to induce hypothermia in a patient through internal and external cooling are provided. Subcutaneous, intravascular, intraperitoneal, gastrointestinal, and lung methods of cooling are carried out using saline ice slurries or other phase-change slurries compatible with human tissue. Perfluorocarbon slurries or other slurry types compatible with human tissue are used for pulmonary cooling. And traditional external cooling methods are improved by utilizing phase-change slurry materials in cooling caps and torso blankets.

  19. Method for inducing hypothermia

    DOE Patents [OSTI]

    Becker, Lance B. (Chicago, IL); Hoek, Terry Vanden (Chicago, IL); Kasza, Kenneth E. (Palos Park, IL)

    2008-09-09T23:59:59.000Z

    Systems for phase-change particulate slurry cooling equipment and methods to induce hypothermia in a patient through internal and external cooling are provided. Subcutaneous, intravascular, intraperitoneal, gastrointestinal, and lung methods of cooling are carried out using saline ice slurries or other phase-change slurries compatible with human tissue. Perfluorocarbon slurries or other slurry types compatible with human tissue are used for pulmonary cooling. And traditional external cooling methods are improved by utilizing phase-change slurry materials in cooling caps and torso blankets.

  20. Coherence-induced entanglement

    E-Print Network [OSTI]

    Li, F. L.; Xiong, H.; Zubairy, M. Suhail

    2005-01-01T23:59:59.000Z

    . These include correlated spontaneous emission laser #3;2#4;, lasing without in- version #3;3#4;, electromagnetically induced transparence #3;4#4; and spontaneous emission cancellation #3;5#4;. Atomic coherence has recently been shown to play a key role...;9#4;. In this paper we discuss an important application where atomic coherence plays a crucial role in creating entangle- ment between two modes of the electromagnetic field inside a doubly resonant cavity at temperature T, which are coupled to two transitions...

  1. Electromagnetic Induced Gravitational Perturbations

    E-Print Network [OSTI]

    T. M. Adamo; E. T. Newman

    2008-07-23T23:59:59.000Z

    We study the physical consequences of two diffferent but closely related perturbation schemes applied to the Einstein-Maxwell equations. In one case the starting space-time is flat while in the other case it is Schwarzschild. In both cases the perturbation is due to a combined electric and magnetic dipole field. We can see, within the Einstein-Maxwell equations a variety of physical consequences. They range from induced gravitational energy-momentum loss, to a well defined spin angular momentum with its loss and a center-of-mass with its equations of motion.

  2. Environmental regulations handbook for enhanced oil recovery

    SciTech Connect (OSTI)

    Madden, M.P. [National Inst. for Petroleum and Energy Research, Bartlesville, OK (United States); Blatchford, R.P.; Spears, R.B. [Spears and Associates, Inc., Tulsa, OK (United States)

    1991-12-01T23:59:59.000Z

    This handbook is intended to assist owners and operators of enhanced oil recovery (EOR) operations in acquiring some introductory knowledge of the various state agencies, the US Environmental Protection Agency, and the many environmental laws, rules and regulations which can have jurisdiction over their permitting and compliance activities. It is a compendium of summarizations of environmental rules. It is not intended to give readers specific working details of what is required from them, nor can it be used in that manner. Readers of this handbook are encouraged to contact environmental control offices nearest to locations of interest for current regulations affecting them.

  3. Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK

    SciTech Connect (OSTI)

    Souza, Sandra C. [Translational Sciences - Translational Medicine, Novartis Institutes for Biomedical Research, Inc., 220 Massachusetts Avenue, Cambridge, MA 02139 (United States)] [Translational Sciences - Translational Medicine, Novartis Institutes for Biomedical Research, Inc., 220 Massachusetts Avenue, Cambridge, MA 02139 (United States); Chau, Mary D.L.; Yang, Qing [Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139 (United States)] [Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139 (United States); Gauthier, Marie-Soleil [Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02140 (United States)] [Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02140 (United States); Clairmont, Kevin B.; Wu, Zhidan; Gromada, Jesper [Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139 (United States)] [Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Inc., 100 Technology Square, Cambridge, MA 02139 (United States); Dole, William P., E-mail: bill.dole@novartis.com [Translational Sciences - Translational Medicine, Novartis Institutes for Biomedical Research, Inc., 220 Massachusetts Avenue, Cambridge, MA 02139 (United States)

    2011-07-08T23:59:59.000Z

    Highlights: {yields} Treatment of differentiated human adipocytes with atrial natriuretic peptide (ANP) increased lipolysis and oxygen consumption by activating AMP-activated protein kinase (AMPK). {yields} ANP stimulated lipid mobilization by selective activation of the alpha2 subunit of AMPK and increased energy utilization through activation of both the alpha1 and alpha2 subunits of AMPK. {yields} ANP enhanced adipocyte mitochondrial oxidative capacity as evidenced by induction of oxidative mitochondrial genes and increase in oxygen consumption. {yields} Exposure of human adipocytes to fatty acids and (TNF{alpha}) induced insulin resistance and decreased expression of mitochondrial genes which was restored to normal by ANP. -- Abstract: Atrial natriuretic peptide (ANP) has been shown to regulate lipid and carbohydrate metabolism providing a possible link between cardiovascular function and metabolism by mediating the switch from carbohydrate to lipid mobilization and oxidation. ANP exerts a potent lipolytic effect via cGMP-dependent protein kinase (cGK)-I mediated-stimulation of AMP-activated protein kinase (AMPK). Activation of the ANP/cGK signaling cascade also promotes muscle mitochondrial biogenesis and fat oxidation. Here we demonstrate that ANP regulates lipid metabolism and oxygen utilization in differentiated human adipocytes by activating the alpha2 subunit of AMPK. ANP treatment increased lipolysis by seven fold and oxygen consumption by two fold, both of which were attenuated by inhibition of AMPK activity. ANP-induced lipolysis was shown to be mediated by the alpha2 subunit of AMPK as introduction of dominant-negative alpha2 subunit of AMPK attenuated ANP effects on lipolysis. ANP-induced activation of AMPK enhanced mitochondrial oxidative capacity as evidenced by a two fold increase in oxygen consumption and induction of mitochondrial genes, including carnitine palmitoyltransferase 1A (CPT1a) by 1.4-fold, cytochrome C (CytC) by 1.3-fold, and peroxisome proliferator-activated receptor-{gamma} coactivator-1{alpha} (PGC-1{alpha}) by 1.4-fold. Treatment of human adipocytes with fatty acids and tumor necrosis factor {alpha} (TNF{alpha}) induced insulin resistance and down-regulation of mitochondrial genes, which was restored by ANP treatment. These results show that ANP regulates lipid catabolism and enhances energy dissipation through AMPK activation in human adipocytes.

  4. The cAMP Response Element Binding protein (CREB) is activated by Insulin-like Growth Factor-1 (IGF-1) and regulates myostatin gene expression in skeletal myoblast

    SciTech Connect (OSTI)

    Zuloaga, R. [Facultad de Ciencias Biolgicas, Universidad Andres Bello, Santiago (Chile)] [Facultad de Ciencias Biolgicas, Universidad Andres Bello, Santiago (Chile); Fuentes, E.N.; Molina, A. [Facultad de Ciencias Biolgicas, Universidad Andres Bello, Santiago (Chile) [Facultad de Ciencias Biolgicas, Universidad Andres Bello, Santiago (Chile); Interdisciplinary Center for Aquaculture Research (INCAR), Vctor Lamas 1290, PO Box 160-C, Concepcin (Chile); Valds, J.A., E-mail: jvaldes@unab.cl [Facultad de Ciencias Biolgicas, Universidad Andres Bello, Santiago (Chile); Interdisciplinary Center for Aquaculture Research (INCAR), Vctor Lamas 1290, PO Box 160-C, Concepcin (Chile)

    2013-10-18T23:59:59.000Z

    Highlights: IGF-1 induces the activation of CREB via IGF-1R/PI3K/PLC signaling pathway. Calcium dependent signaling pathways regulate myostatin gene expression. IGF-1 regulates myostatin gene expression via CREB transcription in skeletal myoblast. -- Abstract: Myostatin, a member of the Transforming Growth Factor beta (TGF-?) superfamily, plays an important role as a negative regulator of skeletal muscle growth and differentiation. We have previously reported that IGF-1 induces a transient myostatin mRNA expression, through the activation of the Nuclear Factor of Activated T cells (NFAT) in an IP{sub 3}/calcium-dependent manner. Here we examined the activation of CREB transcription factor as downstream targets of IGF-1 during myoblast differentiation and its role as a regulator of myostatin gene expression. In cultured skeletal myoblast, IGF-1 induced the phosphorylation and transcriptional activation of CREB via IGF-1 Receptor/Phosphatidylinositol 3-Kinase (PI3K)/Phospholipase C gamma (PLC ?), signaling pathways. Also, IGF-1 induced calcium-dependent molecules such as Calmodulin Kinase II (CaMK II), Extracellular signal-regulated Kinases (ERK), Protein Kinase C (PKC). Additionally, we examined myostatin mRNA levels and myostatin promoter activity in differentiated myoblasts stimulated with IGF-1. We found a significant increase in mRNA contents of myostatin and its reporter activity after treatment with IGF-1. The expression of myostatin in differentiated myoblast was downregulated by the transfection of siRNACREB and by pharmacological inhibitors of the signaling pathways involved in CREB activation. By using pharmacological and genetic approaches together these data demonstrate that IGF-1 regulates the myostatin gene expression via CREB transcription factor during muscle cell differentiation.

  5. Regulation of apoptosis in human cancer cells

    E-Print Network [OSTI]

    Lloyd, S. Julie-Ann (Simone Julie-Ann)

    2005-01-01T23:59:59.000Z

    Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis ...

  6. The accumulations of HIF-1? and HIF-2? by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells

    SciTech Connect (OSTI)

    Xu, Yuan; Li, Yuan [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Li, Huiqiao [Qujing Center for Disease Control and Prevention, Qujing 655000, Yunnan (China)] [Qujing Center for Disease Control and Prevention, Qujing 655000, Yunnan (China); Pang, Ying; Zhao, Yue; Jiang, Rongrong; Shen, Lu [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Zhou, Jianwei; Wang, Xinru [The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China)] [The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); Liu, Qizhan, E-mail: drqzliu@hotmail.com [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China) [Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China); The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, Jiangsu (China)

    2013-01-15T23:59:59.000Z

    The biphasic effects of arsenite, in which low levels of arsenite induce cell proliferation and high levels of arsenite induce DNA damage and apoptosis, apparently contribute to arsenite-induced carcinogenesis. However, the mechanisms underlying this phenomenon are not well understood. In this study, we investigated the effects of different levels of arsenite on cell proliferation, DNA damage and apoptosis as well as on signal transduction pathways in human bronchial epithelial (HBE) cells. Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2? (HIF-2?) in HBE cells. ERK inhibition blocks cell proliferation induced by a low level of arsenite, in part via HIF-2?. In contrast, a high level of arsenite activates c-Jun N-terminal kinases (JNK), which provoke a response to suppress ubiquitinated HIF-1? degradation. Down-regulation of HIF-1? by inhibiting JNK, however, increases the DNA damage but decreases the apoptosis induced by a high level of arsenite. Thus, data in the present study suggest that the accumulations of HIF-1? and HIF-2? by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells. -- Highlights: ? Biphasic effects induced by different concentrations of arsenite. ? Different regulation of ERK or JNK signal pathway by arsenite. ? Different regulation of HIF1? or HIF 2? by arsenite.

  7. Fibroblast growth factor-2 up-regulates the expression of nestin through the RasRafERKSp1 signaling axis in C6 glioma cells

    SciTech Connect (OSTI)

    Chang, Kai-Wei [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China)] [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China); Huang, Yuan-Li [Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan (China)] [Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan (China); Wong, Zong-Ruei; Su, Peng-Han [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China)] [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China); Huang, Bu-Miin [Department of Cell Biology and Anatomy, National Cheng-Kung University, Tainan 701, Taiwan (China)] [Department of Cell Biology and Anatomy, National Cheng-Kung University, Tainan 701, Taiwan (China); Ju, Tsai-Kai [Instrumentation Center, National Taiwan University, Taipei 106, Taiwan (China) [Instrumentation Center, National Taiwan University, Taipei 106, Taiwan (China); Technology Commons, College of Life Science, National Taiwan University, Taipei 106, Taiwan (China); Yang, Hsi-Yuan, E-mail: hyhy@ntu.edu.tw [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China)] [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China)

    2013-05-17T23:59:59.000Z

    Highlights: Nestin expression in C6 glioma cells is induced by FGF-2. Nestin expression is induced by FGF-2 via de novo RNA and protein synthesis. The FGFR inhibitor SU5402 blocks the FGF-2-induced nestin expression. The mRNA of FGFR1 and 3 are detected in C6 glioma cells. RasRafERKSp1 signaling pathway is responsibe for FGF-2-induced nestin expression. -- Abstract: Nestin is a 240-kDa intermediate filament protein expressed mainly in neural and myogenic stem cells. Although a substantial number of studies have focused on the expression of nestin during development of the central nervous system, little is known about the factors that induce and regulate its expression. Fibroblast growth factor-2 (FGF-2) is an effective mitogen and stimulates the proliferation and differentiation of a subset of nestin-expressing cells, including neural progenitor cells, glial precursor cells, and smooth muscle cells. To assess whether FGF-2 is a potent factor that induces the expression of nestin, C6 glioma cells were used. The results showed that nestin expression was up-regulated by FGF-2 via de novo RNA and protein synthesis. Our RT-PCR results showed that C6 glioma cells express FGFR1/3, and FGFRs is required for FGF-2-induced nestin expression. Further signaling analysis also revealed that FGF-2-induced nestin expression is mediated through FGFRMAPKERK signaling axis and the transcriptional factor Sp1. These findings provide new insight into the regulation of nestin in glial system and enable the further studies on the function of nestin in glial cells.

  8. Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration

    SciTech Connect (OSTI)

    Samarzija, Ivana [Ecole Polytechnique Federale Lausanne (EPFL), Department of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne (Switzerland)] [Ecole Polytechnique Federale Lausanne (EPFL), Department of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne (Switzerland); Beard, Peter, E-mail: peter.beard@epfl.ch [Ecole Polytechnique Federale Lausanne (EPFL), Department of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne (Switzerland)] [Ecole Polytechnique Federale Lausanne (EPFL), Department of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne (Switzerland)

    2012-08-17T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Unknown cellular mutations complement papillomavirus-induced carcinogenesis. Black-Right-Pointing-Pointer Hedgehog pathway components are expressed by cervical cancer cells. Black-Right-Pointing-Pointer Hedgehog pathway activators and inhibitors regulate cervical cancer cell biology. Black-Right-Pointing-Pointer Cell immortalization by papillomavirus and activation of Hedgehog are independent. -- Abstract: Human papillomavirus (HPV) infection is considered to be a primary hit that causes cervical cancer. However, infection with this agent, although needed, is not sufficient for a cancer to develop. Additional cellular changes are required to complement the action of HPV, but the precise nature of these changes is not clear. Here, we studied the function of the Hedgehog (Hh) signaling pathway in cervical cancer. The Hh pathway can have a role in a number of cancers, including those of liver, lung and digestive tract. We found that components of the Hh pathway are expressed in several cervical cancer cell lines, indicating that there could exists an autocrine Hh signaling loop in these cells. Inhibition of Hh signaling reduces proliferation and survival of the cervical cancer cells and induces their apoptosis as seen by the up-regulation of the pro-apoptotic protein cleaved caspase 3. Our results indicate that Hh signaling is not induced directly by HPV-encoded proteins but rather that Hh-activating mutations are selected in cells initially immortalized by HPV. Sonic Hedgehog (Shh) ligand induces proliferation and promotes migration of the cervical cancer cells studied. Together, these results indicate pro-survival and protective roles of an activated Hh signaling pathway in cervical cancer-derived cells, and suggest that inhibition of this pathway may be a therapeutic option in fighting cervical cancer.

  9. Regulation of Branching by Phytochrome and Phytohormones

    E-Print Network [OSTI]

    Krishnareddy, Srirama R.

    2012-07-16T23:59:59.000Z

    ratios (R:FR) perceived by phytochromes serve as a warning signal about impending competition for light resources and lead to shade avoidance responses (SARs), including reduced branching. The R:FR regulates branching in both a bud autonomous and non...

  10. Denman Forestry Issues Series: Washington's Forest Regulations

    E-Print Network [OSTI]

    Borenstein, Elhanan

    Denman Forestry Issues Series: Washington's Forest Regulations and Their Impacts on The Private College of Forest Resources continued its Denman Forestry Issues Series on May 30, 2001. Alumni landowners. Policy analysts and speakers representing the Washington Farm Forestry Assn., Washington Forest

  11. Regulation No. Department of the Army

    E-Print Network [OSTI]

    US Army Corps of Engineers

    AREAS IN CONNECTION WITH DREDGING Distribution Restriction Statement Approved for public release ESTABLISHMENT OF WETLAND AREAS IN CONNECTION WITH DREDGING 1. Purpose. This regulation provides guidance for the establishment of wetland areas in connection with dredging required as part of water resources development

  12. Method for regulation of plant lignin composition

    DOE Patents [OSTI]

    Chapple, Clint (West Lafayette, IN)

    1999-01-01T23:59:59.000Z

    A method is disclosed for the regulation of lignin composition in plant tissue. Plants are transformed with a gene encoding an active F5H gene. The expression of the F5H gene results in increased levels of syringyl monomer providing a lignin composition more easily degraded with chemicals and enzymes.

  13. Effects of caseinomacropeptide (CMP) on digestion regulation

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Effects of caseinomacropeptide (CMP) on digestion regulation M Yvon S Beucher P Guilloteau2 I Le sums up the knowledge concerning its effects on the digestive function. Part 1 recalls the origin to be defined accurately. Part 2 summarizes the effects of CMP on digestive secretions. The major effect

  14. RULES AND REGULATIONS Title 7--AGRICULTURE

    E-Print Network [OSTI]

    Guiltinan, Mark

    RULES AND REGULATIONS Title 7--AGRICULTURE DEPARTMENT OF AGRICULTURE [7 PA. CODE CH. 130b] Nutrient Management Certification [35 Pa.B. 6504] The Department of Agriculture (Department), under section 7(a or the Senate or House Agricultural and Rural Affairs Committees regarding the proposed rulemaking

  15. Einstein Room Reservations Rules and Regulations

    E-Print Network [OSTI]

    Yates, Andrew

    Einstein Room Reservations Rules and Regulations Before Reservation: Requests are not confirmed Activities, Joan Junger, (718) 430-2105 or student.activities@einstein.yu.edu. A meeting or conversation in accordance to Albert Einstein College of Medicine's Alcohol Policy. Before your request is confirmed you must

  16. Neurofibromin Regulation of ERK Signaling Modulates

    E-Print Network [OSTI]

    Silva, Alcino

    Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning Yijun Cui,1 Rui M@mednet.ucla.edu DOI 10.1016/j.cell.2008.09.060 SUMMARY We uncovered a role for ERK signaling in GABA re- lease, long demonstrate that neurofibromin modulates ERK/synapsin I-dependent GABA re- lease, which in turn modulates

  17. AwardRegulations 152 2012 Calendar

    E-Print Network [OSTI]

    Hickman, Mark

    of Bachelor of Engineering. 8. Concurrent Enrolment in BE(Hons) and BCom Degrees A candidate who enrols concurrently for the Degree of Bachelor of Commerce and Bachelor of Engineering with Honours shall, in order of Engineering with Honours (BE(Hons)) See also General Course and Examination Regulations. 1. Requirements

  18. Regulation of phosphate starvation response in Arabidopsis

    E-Print Network [OSTI]

    Thomas, Beth Elene Armstrong

    2007-04-25T23:59:59.000Z

    Biochemical Responses of Plants to Phosphate Starvation???. 3 Metabolic Adaptations to Decrease Plant Pi Requirements???. 9 Pi Starvation Regulated Gene Expression in Plants??????. 11... x LIST OF FIGURES FIGURE Page 1.1 Some known components and their relationship in the Pi starvation...

  19. Energy Regulation and the Environment (Spring 2006)

    E-Print Network [OSTI]

    Kammen, Daniel M.

    since so many energy choicesthe use of oil, natural gas, coal, nuclear, the green alternatives the greatest threats to the global environment. This course introduces students to the legal, economic problems. The course focuses primarily on the regulation and design of electricity systems and markets

  20. Energy Regulation and the Environment (Spring 2008

    E-Print Network [OSTI]

    Kammen, Daniel M.

    , since so many energy choicesthe use of oil, natural gas, coal, nuclear, the green alternatives the greatest threats to the global environment. This course introduces students to the legal, economic problems. The course focuses primarily on the regulation and design of electricity systems and markets

  1. Empirical Multiscale Networks of Cellular Regulation

    E-Print Network [OSTI]

    de Bivort, Benjamin

    Empirical Multiscale Networks of Cellular Regulation Benjamin de Bivort1* , Sui Huang2,3,4 , Yaneer Bar-Yam5 1 Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, Boston, Massachusetts, United States of America, 3 Department of Pathology, Children's Hospital

  2. COMPUTATIONAL COMPARATIVE GENOMICS: GENES, REGULATION, EVOLUTION

    E-Print Network [OSTI]

    Kellis, Manolis

    COMPUTATIONAL COMPARATIVE GENOMICS: GENES, REGULATION, EVOLUTION by Manolis (Kellis) Kamvysselis B.S. Electrical Engineering and Computer Science; M. Eng. Computer Science and Engineering Massachusetts Institute at the Massachusetts Institute of Technology June 2003 2003 Massachusetts Institute of Technology All rights reserved

  3. RULES AND REGULATIONS GOVERNING PUBLIC USE

    E-Print Network [OSTI]

    US Army Corps of Engineers

    .12 Restrictions. 327.13 Explosives, firearms, other weapons and fireworks. 327.14 Public property. 327 of Engineers. ALL OTHER FEDERAL, STATE AND LOCAL LAWS AND REGULATIONS REMAIN IN FULL FORCE AND EFFECT WHERE force and effect on project lands or waters which are outgranted by the District Commander by lease

  4. Student Regulations and Procedures Academic Division

    E-Print Network [OSTI]

    Student Regulations and Procedures Academic Division 2007/2008 11 Students Union Code information regarding their course, tuition fees, award ceremonies and other matters www.mmu.ac.uk/academic's Articles of Government (Article 1.1). As prescribed in the Articles of Government (Article 12

  5. Voltage regulation in linear induction accelerators

    DOE Patents [OSTI]

    Parsons, William M. (Santa Fe, NM)

    1992-01-01T23:59:59.000Z

    Improvement in voltage regulation in a Linear Induction Accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance.

  6. LIBRARY REGULATIONS 1. THE LIBRARY POLICY COMMITTEE

    E-Print Network [OSTI]

    Schellekens, Michel P.

    1 LIBRARY REGULATIONS 1. THE LIBRARY POLICY COMMITTEE 1.1 The Library Policy Committee shall shall be: [i] to formulate proposals in regard to policy matters relating to the Library for consideration by the Academic Council and the Governing Body; [ii] to monitor the implementation of Library

  7. Voltage regulation in linear induction accelerators

    DOE Patents [OSTI]

    Parsons, W.M.

    1992-12-29T23:59:59.000Z

    Improvement in voltage regulation in a linear induction accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core is disclosed. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance. 4 figs.

  8. FLORIDA BOARD OF GOVERNORS Regulation Development Procedure

    E-Print Network [OSTI]

    Wu, Shin-Tson

    be any natural person with an interest within the zone of interest protected or regulated who suffers. A substantially affected person shall also mean any association with a majority of natural persons as members, amendment or repeal shall include publication on a clearly marked area on the university's internet website

  9. REGULATIONS OF THE UNIVERSITY OF FLORIDA

    E-Print Network [OSTI]

    Pilyugin, Sergei S.

    and official recognition that the behavior has violated the Student Conduct Code. #12;2 (b) Loss of University1 REGULATIONS OF THE UNIVERSITY OF FLORIDA 4.047 Student Honor Code and Student Conduct Code Code or the Student Conduct Code shall be subject to sanctions commensurate with the offense

  10. Jitter Regulation for Multiple Streams (Extended Abstract)

    E-Print Network [OSTI]

    Hay, David

    Jitter Regulation for Multiple Streams (Extended Abstract) David Hay and Gabriel Scalosub Computer as possible; the smoothness of a traffic is typically captured by its delay jitter, i.e., the difference between the maximal and minimal end-to-end delays. The task of minimizing the jitter is done by jitter

  11. Regional Focus on GM Crop Regulation

    E-Print Network [OSTI]

    Church, George M.

    Regional Focus on GM Crop Regulation THE RECENT MEDIA COVERAGE OF THE DEVEL- opments in Brazil for com- mercial genetically modified (GM) crops in both the scientific and regulatory arena. The release of GM crops in these coun- tries might result in the unintentional entry of GM seeds into neighboring

  12. Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries

    SciTech Connect (OSTI)

    Yoshikawa, Yukitaka; Miyashita, Taishi; Higuchi, Satonori [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920?1192 (Japan)] [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920?1192 (Japan); Tsuneyama, Koichi [Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Sugitani, Toyama 930?0194 (Japan)] [Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Sugitani, Toyama 930?0194 (Japan); Endo, Shinya [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920?1192 (Japan)] [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920?1192 (Japan); Tsukui, Tohru [Research Center for Genomic Medicine, Saitama Medical University, Yamane, Hidaka 350?1241 (Japan)] [Research Center for Genomic Medicine, Saitama Medical University, Yamane, Hidaka 350?1241 (Japan); Toyoda, Yasuyuki; Fukami, Tatsuki; Nakajima, Miki [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920?1192 (Japan)] [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920?1192 (Japan); Yokoi, Tsuyoshi, E-mail: tyokoi@p.kanazawa-u.ac.jp [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920?1192 (Japan)] [Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920?1192 (Japan)

    2012-10-01T23:59:59.000Z

    Although estrogen receptor (ER)? agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury caused by hepatotoxicants as well as ischemiareperfusion. The functional mechanisms of ER? have yet to be elucidated in drug-induced or chemical-induced liver injury. The present study investigated the effects of an ER? agonist, selective ER modulators (SERMs) and an ER antagonist on drug-induced and chemical-induced liver injuries caused by acetaminophen, bromobenzene, diclofenac, and thioacetamide (TA). We observed hepatoprotective effects of EE2, tamoxifen (TAM) and raloxifene pretreatment in female mice that were exposed to a variety of hepatotoxic compounds. In contrast, the ER antagonist did not show any hepatoprotective effects. DNA microarray analyses suggested that monocyte to macrophage differentiation-associated 2 (Mmd2) protein, which has an unknown function, is commonly increased by TAM and RAL pretreatment, but not by pretreatment with the ER antagonist. In ER?-knockout mice, the hepatoprotective effects of TAM and the increased expression of Mmd2 mRNA were not observed in TA-induced liver injury. To investigate the function of Mmd2, the expression level of Mmd2 mRNA was significantly knocked down to approximately 30% in mice by injection of siRNA for Mmd2 (siMmd2). Mmd2 knockdown resulted in a reduction of the protective effects of TAM on TA-induced liver injury in mice. This is the first report of the involvement of ER? in drug-induced or chemical-induced liver injury. Upregulation of Mmd2 protein in the liver was suggested as the mechanism of the hepatoprotective effects of EE2 and SERMs. -- Highlights: ? Liver injury induced by drugs or chemicals was investigated in mice. ? Liver injury was suppressed by pretreatment with tamoxifen in female mice. ? Mmd2, whose function was unknown, could be a candidate gene for liver protection. ? Tamoxifen up-regulated Mmd2 mRNA expression via ER?.

  13. Preferences for change: Do individuals prefer voluntary actions, soft regulations, or hard regulations to

    E-Print Network [OSTI]

    Indiana University

    ' environmental attitudes (as assessed using the New Ecological Paradigm scale) had a strong positive relationship states sued the EPA to force the agency to regulate carbon dioxide and other green- house gases (GHGs

  14. SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation

    E-Print Network [OSTI]

    Zainabadi, Kayvan

    2009-01-01T23:59:59.000Z

    As mammals age, osteoblast numbers decrease while osteoclast numbers increase, resulting in age-related or post-menopausal osteoporosis. SirT1, the mammalian orthologue of yeast Sir2, has been shown to be a negative regulator ...

  15. Atomic Energy and Radioactive Substances: Licensing and Regulation of Sites: The Nuclear Installations Regulations, 1962

    E-Print Network [OSTI]

    Wood, Richard; Maclay, John. S.

    1962-01-01T23:59:59.000Z

    These regulations, made by the Minister of Power and the Secretary of State for Scotland acting jointly, prescribe for the purpose of subsection (1)(b) of section one of the Nuclear Installations (Licensing and Insurance) Act, 1959, certain classes...

  16. Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway

    SciTech Connect (OSTI)

    Wang, Yi-Fen; Shyu, Huey-Wen [Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan (China)] [Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan (China); Chang, Yi-Chuang [Department of Nursing, Fooyin University, Kaohsiung, Taiwan (China)] [Department of Nursing, Fooyin University, Kaohsiung, Taiwan (China); Tseng, Wei-Chang [Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan (China)] [Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan (China); Huang, Yeou-Lih [Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan (China)] [Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Lin, Kuan-Hua; Chou, Miao-Chen; Liu, Heng-Ling [Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan (China)] [Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan (China); Chen, Chang-Yu, E-mail: mt037@mail.fy.edu.tw [Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan (China)] [Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan (China)

    2012-03-01T23:59:59.000Z

    Nickel compounds are known to be toxic and carcinogenic in kidney and lung. In this present study, we investigated the roles of reactive oxygen species (ROS) and mitochondria in nickel (II) acetate-induced cytotoxicity and apoptosis in the HK-2 human renal cell line. The results showed that the cytotoxic effects of nickel (II) involved significant cell death and DNA damage. Nickel (II) increased the generation of ROS and induced a noticeable reduction of mitochondrial membrane potential (MMP). Analysis of the sub-G1 phase showed a significant increase in apoptosis in HK-2 cells after nickel (II) treatment. Pretreatment with N-acetylcysteine (NAC) not only inhibited nickel (II)-induced cell death and DNA damage, but also significantly prevented nickel (II)-induced loss of MMP and apoptosis. Cell apoptosis triggered by nickel (II) was characterized by the reduced protein expression of Bcl-2 and Bcl-xL and the induced the protein expression of Bad, Bcl-Xs, Bax, cytochrome c and caspases 9, 3 and 6. The regulation of the expression of Bcl-2-family proteins, the release of cytochrome c and the activation of caspases 9, 3 and 6 were inhibited in the presence of NAC. These results suggest that nickel (II) induces cytotoxicity and apoptosis in HK-2 cells via ROS generation and that the mitochondria-mediated apoptotic signaling pathway may be involved in the positive regulation of nickel (II)-induced renal cytotoxicity.

  17. Induced Currents, Eddy Currents and

    E-Print Network [OSTI]

    Tobar, Michael

    Lecture 11 Induced Currents, Eddy Currents and Maxwell's Equations 1 Faraday Disk Dynamo F = q Eddy Currents We have learnt that changing magnetic fields can induce electric fields in conductors 108 ms-1 16 #12;In this lecture and the next Eddy Currents: We have covered Sect. 29

  18. Effortful control and spontaneous regulation of emotional behavior in children

    E-Print Network [OSTI]

    Kieras, Jessica E

    2013-02-22T23:59:59.000Z

    The development of Effortful Control and Regulation of Emotion in children was examined in this study. Of particular interest was the relationship between self-regulation and responses to social norms. Participants were between ages three and five...

  19. A Dynamic Hobbesian Approach to Aggression and Self-Regulation

    E-Print Network [OSTI]

    Geldhof, Gordon John

    2008-06-18T23:59:59.000Z

    solid theoretical framework for examining self-regulation, aggression, and resource control. This paradigm encourages researchers to consider the functions of aggression (reactive vs. instrumental) and forms of self-regulation (active vs. automatic...

  20. Regulation Indentifier Number Title/Subject/Purpose Rule Type

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of a specific rule, please see the Federal Register at https:www.regulations.gov. Regulation Indentifier Number TitleSubjectPurpose Rule Type Status 1991-AB82 Acquisition...

  1. Understanding regulation of mRNA by RNA binding proteins

    E-Print Network [OSTI]

    Robertson, Alexander De Jong

    2014-01-01T23:59:59.000Z

    Posttranscriptional regulation of mRNA by RNA-binding proteins plays key roles in regulating the transcriptome over the course of development, between tissues and in disease states. The specific interactions between mRNA ...

  2. Oil and Gas Commission General Rules and Regulations (Arkansas)

    Broader source: Energy.gov [DOE]

    The Oil and Gas Commission General Rules and Regulations are the body of rules and regulations that relate to natural gas production in Arkansas. The statutory law is found Arkansas Code Annotated...

  3. FLORIDA ATLANTIC UNVIERSITY NOTICE OF PROPOSED REGULATION REPEAL

    E-Print Network [OSTI]

    Richman, Fred

    TITLE AND NUMBER: Statutory References (1.004). SUMMARY: Regulation 1.004 was last amended in 1987 OF REGULATIONS IS: Myrlande Dessalines, Paralegal, Office of the General Counsel, 777 Glades Road, Boca Raton

  4. acid base regulation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The adipocyte fatty acid-binding protein aP2 regulates systemic glucose (more) Shum, Bennett Oh Vic 2007-01-01 3 Stabilized epoxygenated fatty acids regulate inflammation, pain,...

  5. Amino acid regulation of mTORC1

    E-Print Network [OSTI]

    Bar-Peled, Liron

    2013-01-01T23:59:59.000Z

    Mammalian target of rapamycin complex I (mTORC1) is an atypical Ser/Thr kinase that regulates cellular and organismal growth. Accordingly, mTORC1 has substantial roles in regulating insulin sensitivity and lifespan, and ...

  6. Energy storage for frequency regulation on the electric grid

    E-Print Network [OSTI]

    Leitermann, Olivia

    2012-01-01T23:59:59.000Z

    Ancillary services such as frequency regulation are required for reliable operation of the electric grid. Currently, the same traditional thermal generators that supply bulk power also perform nearly all frequency regulation. ...

  7. NNSA Updates Export Control Regulation | National Nuclear Security...

    National Nuclear Security Administration (NNSA)

    Updates Export Control Regulation | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation...

  8. The London Gas Undertakings (Regulations) Act 1939 (Modification) Order 1965

    E-Print Network [OSTI]

    Lee, Fred

    1965-01-01T23:59:59.000Z

    STATUTORY INSTRUMENTS 1965 No. 1560 LONDON GOVERNMENT The London Gas Undertakings (Regulations) Act 1939 (Modification) Order 1965...

  9. The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells

    SciTech Connect (OSTI)

    Jiang, Yue; Hu, Yali; Zhao, Jing; Zhen, Xin [Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008 (China)] [Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008 (China); Yan, Guijun, E-mail: yanguijun33@gmail.com [Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008 (China)] [Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008 (China); Sun, Haixiang, E-mail: stevensunz@163.com [Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008 (China)] [Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008 (China)

    2011-01-14T23:59:59.000Z

    Research highlights: {yields} Decidually produced PRL plays a key role during pregnancy. {yields} Overexpression of Nur77 increased PRL mRNA expression and enhanced decidual PRL promoter activity. {yields} Knockdown of Nur77 decreased decidual PRL secretion induced by 8-Br-cAMP and MPA. {yields} Nur77 is a novel transcription factor that plays an active role in decidual prolactin expression. -- Abstract: Prolactin (PRL) is synthesized and released by several extrapituitary tissues, including decidualized stromal cells. Despite the important role of decidual PRL during pregnancy, little is understood about the factors involved in the proper regulation of decidual PRL expression. Here we present evidence that the transcription factor Nur77 plays an active role in decidual prolactin expression in human endometrial stromal cells (hESCs). Nur77 mRNA expression in hESCs was significantly increased after decidualization stimulated by 8-Br-cAMP and medroxyprogesterone acetate (MPA). Adenovirus-mediated overexpression of Nur77 in hESCs markedly increased PRL mRNA expression and enhanced decidual PRL promoter (dPRL/-332Luc) activity in a concentration-dependent manner. Furthermore, knockdown of Nur77 in hESCs significantly decreased decidual PRL promoter activation and substantially attenuated PRL mRNA expression and PRL secretion (P < 0.01) induced by 8-Br-cAMP and MPA. These results demonstrate that Nur77 is a novel transcription factor that contributes significantly to the regulation of prolactin gene expression in human endometrial stromal cells.

  10. RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line

    SciTech Connect (OSTI)

    Poch, Enric [Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera-CEU, Valencia (Spain); Minambres, Rebeca [Laboratorio de Patologia Celular, Centro de Investigacion Principe Felipe, Valencia (Spain); Mocholi, Enric [Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera-CEU, Valencia (Spain); Ivorra, Carmen [Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera-CEU, Valencia (Spain); Perez-Arago, Amparo [Laboratorio de Patologia Celular, Centro de Investigacion Principe Felipe, Valencia (Spain); Guerri, Consuelo [Laboratorio de Patologia Celular, Centro de Investigacion Principe Felipe, Valencia (Spain); Perez-Roger, Ignacio [Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera-CEU, Valencia (Spain)]. E-mail: iperez@uch.ceu.es; Guasch, Rosa M. [Laboratorio de Patologia Celular, Centro de Investigacion Principe Felipe, Valencia (Spain)]. E-mail: guasch@cipf.es

    2007-02-15T23:59:59.000Z

    Rho GTPases are important regulators of actin cytoskeleton, but they are also involved in cell proliferation, transformation and oncogenesis. One of this proteins, RhoE, inhibits cell proliferation, however the mechanism that regulates this effect remains poorly understood. Therefore, we undertook the present study to determine the role of RhoE in the regulation of cell proliferation. For this purpose we generated an adenovirus system to overexpress RhoE in U87 glioblastoma cells. Our results show that RhoE disrupts actin cytoskeleton organization and inhibits U87 glioblastoma cell proliferation. Importantly, RhoE expressing cells show a reduction in Rb phosphorylation and in cyclin D1 expression. Furthermore, RhoE inhibits ERK activation following serum stimulation of quiescent cells. Based in these findings, we propose that RhoE inhibits ERK activation, thereby decreasing cyclin D1 expression and leading to a reduction in Rb inactivation, and that this mechanism is involved in the RhoE-induced cell growth inhibition. Moreover, we also demonstrate that RhoE induces apoptosis in U87 cells and also in colon carcinoma and melanoma cells. These results indicate that RhoE plays an important role in the regulation of cell proliferation and survival, and suggest that this protein may be considered as an oncosupressor since it is capable to induce apoptosis in several tumor cell lines.

  11. Regulation and Property Values in the United States: The High Cost of Monopoly

    E-Print Network [OSTI]

    Quigley, John M.

    2007-01-01T23:59:59.000Z

    F. T. Ventre. 1971. Local regulation of building: Agencies,local government land use regulation. Cambridge, MA: LincolnManhattan so expensive? Regulation and the rise in housing

  12. Beyond control - The Uncertainties and Diverging Images of Swedish Chemicals Regulation

    E-Print Network [OSTI]

    Haikola, Simon

    2015-01-01T23:59:59.000Z

    and European chemicals regulation. Journal of EuropeanSwedish chemicals regulation: An overview and analysis. Riskprinciple in chemical regulation: A constructive critique.

  13. The Regulation of E-learning: New National and International Policy Perspectives

    E-Print Network [OSTI]

    Harley, Diane; Lawrence, Shannon

    2007-01-01T23:59:59.000Z

    Colleges (WASC) THE REGULATION OF E-LEARNING: NEW NATIONALcshe.berkeley.edu/research/regulation/documents/dla_interim_and institutional norms. Regulation is generally driven by

  14. Energy Regulation, Roll Call Votes and Regional Resources: Evidence from Russia

    E-Print Network [OSTI]

    Grigoriadis, Theocharis N; Torgler, Benno

    2007-01-01T23:59:59.000Z

    Problems of the North 20. Regulation and Work organizationV. "Reform and Regulation of Natural Monopolies." (InEnergy Regulation, Roll Call Votes and Regional Resources:

  15. Shaping the terms of competition : environmental regulation and corporate strategies to reduce diesel vehicle emissions

    E-Print Network [OSTI]

    Ng, Christine Bik-Kay, 1979-

    2006-01-01T23:59:59.000Z

    Environmental regulations are typically portrayed as an outside force stimulating development of environmental technologies in regulated industries. In reality, firms influence regulation by communicating their technological ...

  16. The Regulation of District Energy Systems Peter Ostergaard, Smart Planning for Communities

    E-Print Network [OSTI]

    Pedersen, Tom

    The Regulation of District Energy Systems Peter Ostergaard, Smart Planning for Communities ...................................................................................... 6 4. District Energy Systems BCUC-Regulated.....................................................................11 5. District Energy Systems Local Government Regulated

  17. Update on adipocyte hormones - Regulation of energy balance and carbohydrate/lipid metabolism

    E-Print Network [OSTI]

    Havel, Peter J. D.V.M., Ph.D.

    2004-01-01T23:59:59.000Z

    ghrelin and the regulation of energy balance: a hypothalamicfree fatty acid. regulation of energy homeostasis is forfor leptin in the regulation of energy balance in humans (

  18. Rethinking Downstream Regulation: California's Opportunity to Engage Households in Reducing Greenhouse Gases

    E-Print Network [OSTI]

    2008-01-01T23:59:59.000Z

    D. , et al. , Rethinking downstream regulation: CaliforniasD. , et al. , Rethinking downstream regulation: Californiaslocate/enpol Rethinking downstream regulation: Californias

  19. Environmental radiation exposure: Regulation, monitoring, and assessment

    SciTech Connect (OSTI)

    Chen, S.Y.; Yu, C.; Hong, K.J.

    1991-01-01T23:59:59.000Z

    Radioactive releases to the environment from nuclear facilities constitute a public health concern. Protecting the public from such releases can be achieved through the establishment and enforcement of regulatory standards. In the United States, numerous standards have been promulgated to regulate release control at nuclear facilities. Most recent standards are more restrictive than those in the past and require that radioactivity levels be as low as reasonably achievable (ALARA). Environmental monitoring programs and radiological dose assessment are means of ensuring compliance with regulations. Environmental monitoring programs provide empirical information on releases, such as the concentrations of released radioactivity in environmental media, while radiological dose assessment provides the analytical means of quantifying dose exposures for demonstrating compliance.

  20. Diffusion, dimensionality and noise in transcriptional regulation

    E-Print Network [OSTI]

    Gasper Tkacik; William Bialek

    2007-12-12T23:59:59.000Z

    The precision of biochemical signaling is limited by randomness in the diffusive arrival of molecules at their targets. For proteins binding to the specific sites on the DNA and regulating transcription, the ability of the proteins to diffuse in one dimension by sliding along the length of the DNA, in addition to their diffusion in bulk solution, would seem to generate a larger target for DNA binding, consequently reducing the noise in the occupancy of the regulatory site. Here we show that this effect is largely cancelled by the enhanced temporal correlations in one dimensional diffusion. With realistic parameters, sliding along DNA has surprisingly little effect on the physical limits to the precision of transcriptional regulation.

  1. Development of EPA radiation site cleanup regulations

    SciTech Connect (OSTI)

    Burnett, J.

    1994-12-31T23:59:59.000Z

    This paper summarizes the EPA program to develop radiation site cleanup and identifies many of the issues related to that effort. The material is drawn from portions of the Agency`s Issues Paper on Radiation Site Cleanup Regulations (EPA 402-R-93-084). The site cleanup regulations will be designed to protect human health and the environment and to facilitate the cleanup of sites. EPA believes that developing specific cleanup standards for radionuclides will ensure consistent, protective, and cost-effective site remediation. They will apply to all Federal facilities such as those operated by the US Department of Energy (DOE), the US Department of Defense (DoD), and sites licensed by the US Nuclear Regulatory Commission (NRC) and its Agreement States.

  2. Regelsysteme 1 10. Tutorial LQ Regulator und Kalman Filter

    E-Print Network [OSTI]

    Lygeros, John

    Regelsysteme 1 10. Tutorial LQ Regulator und Kalman Filter Dave Ochsenbein Institut fur Automatik ETH Zurich HS 2013 Dave Ochsenbein Regelsysteme 1 HS 2013 #12;10. Tutorial LQ Regulator und Kalman Filter Gliederung 10.1. Varia 10.2. LQ-Regulator 10.3. Kalman-Bucy Filter 10.4. Eigenschaften des

  3. Computational Molecular Biology of Genome Expression and Regulation

    E-Print Network [OSTI]

    Computational Molecular Biology of Genome Expression and Regulation Michael Q. Zhang, Ph.D. Cold in genome expression and regulation network in which better modern statistical and machine learning referring to the cellular processes that lead to pro- tein production, is controlled and regulated

  4. Emotion Regulation Choice: A Conceptual Framework and Supporting Evidence

    E-Print Network [OSTI]

    Gross, James J.

    Emotion Regulation Choice: A Conceptual Framework and Supporting Evidence Gal Sheppes Tel Aviv that remains virtually unexplored is that of emotion regulation. This is surprising given that healthy adaptation requires flexibly choosing between regulation strategies in a manner that is responsive

  5. From Biophysics to Evolutionary Genetics: Statistical Aspects of Gene Regulation

    E-Print Network [OSTI]

    Lssig, Michael

    From Biophysics to Evolutionary Genetics: Statistical Aspects of Gene Regulation Michael L.e., if the protein produced from it is present in the cell. Genes interact by regulation: the protein of one gene can influence the production of protein from another gene. Gene regulation can take place during transcription

  6. Supply Regulation Techniques for Phase-Locked Loops

    E-Print Network [OSTI]

    Palermo, Sam

    Supply Regulation Techniques for Phase-Locked Loops Vivekananth Gurumoorthy and Samuel Palermo-- Phase-locked loops (PLLs) which employ voltage regulators for low supply-noise sensitivity often rely. This paper compares various supply regulation techniques on the basis of their ability to reject noise from

  7. Regulation and controlled synchronization for complex dynamical systems

    E-Print Network [OSTI]

    Eindhoven, Technische Universiteit

    Regulation and controlled synchronization for complex dynamical systems H.J.C. Huijberts #3; H of controlled synchronization as a regulator problem. In controlled synchronization one is given autonomous of the problem where the standard solvability assumptions for the regulator problem are not met turn out to have

  8. Density regulation in annual plant communities under variable resource levels

    E-Print Network [OSTI]

    Novoplansky, Ariel

    Density regulation in annual plant communities under variable resource levels Hagit Shilo. E. and Turkington, R. 2005. Density regulation in annual plant communities under variable resource levels. / Oikos 108: 241/252. Density regulation is assumed to be common, but is very rarely tested

  9. hal-00154748,version1-14Jun2007 Attenuation Regulation

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    hal-00154748,version1-14Jun2007 Attenuation Regulation as a Term Rewriting System Eugene Asarin1,lyubetsk@iitp.ru Abstract The classical attenuation regulation of gene expression in bac- teria is considered. We propose a probabilistic term rewriting system modeling the whole process of such a regulation. 1 Introduction Modeling

  10. Is My Operation Affected By This New Regulation?

    E-Print Network [OSTI]

    Bolding, M. Chad

    Is My Operation Affected By This New Regulation? This provision applies to all livestock operations that feed ruminants. The regulation applies to "establishments and individuals that are responsible operations, are subject to the regulation. ! Examples include dairies, cattle feedlots, calf and lamb raising

  11. Metabolic Regulation and Anticancer Drug Resistance in the Yeast

    E-Print Network [OSTI]

    Metabolic Regulation and Anticancer Drug Resistance in the Yeast Saccharomyces cerevisiae Mattias-91-576-8059-4 2014 Mattias Carlsson, Uppsala Print: SLU Service/Repro, Uppsala 2014 #12;Metabolic Regulation regulation by the yeast Rph1p protein, a zinc finger transcription factor which also contains a jmjC domain

  12. FISHERY REGULATION VIA OPTIMAL CONTROL THEORY1 WILLIAM J. PALM'

    E-Print Network [OSTI]

    FISHERY REGULATION VIA OPTIMAL CONTROL THEORY1 WILLIAM J. PALM' ABSTRACT This paper attempts such a feedback scheme for fishery regulation. A single-variable logistic model is used to introduce the basic regulation. The Linear-Quadratic Optimal Control Problem, which has been widely applied in engineering

  13. Cognitive Emotion Regulation Insights From Social Cognitive and Affective Neuroscience

    E-Print Network [OSTI]

    Ochsner, Kevin

    . Imaging studies have con- tributed to the development of a multilevel model of emo- tion regulation in emotional control. In this article, we review imaging studies of one type of cognitive emotion regulation understanding of cognitive emotion regulation. MULTILEVEL MODELS One tenet of SCAN research is that behavior

  14. Output regulation problem for differentiable families of linear systems

    E-Print Network [OSTI]

    Politècnica de Catalunya, Universitat

    The output regulation problem arose as one of the main research topics in linear control theory in the 1970s regulation when modeled by a global or a local differentiable family. Partially supported by DGICYT n.PB97Output regulation problem for differentiable families of linear systems Albert Compta and Marta Pe

  15. Self-Regulation and Negotiated Agreements: Complements or Substitutes?

    E-Print Network [OSTI]

    Lyon, Thomas P.

    a general model of the two tools, in which the firm can self-regulate both before and after negotiations, and industry self-regulation all have become more prominent as command-and-control reg- ulation, and evenSelf-Regulation and Negotiated Agreements: Complements or Substitutes? Thomas P. Lyon and John W

  16. REVISED 3/27/01 Advanced Workshop in Regulation

    E-Print Network [OSTI]

    Lin, Xiaodong

    NETWORK INDUSTRIES November 17, 2000 AUCTIONS IN NETWORK INDUSTRIES January 19, 2001 INCENTIVE REGULATION" January 19, 2001 INCENTIVE REGULATION: MAKING IT WORK Michael A. Crew (Rutgers University) and Paul R. Kleindorfer (University of Pennsylvania) "Incentive Regulation: Theory and Practice" Karl McDermot (NERA

  17. Frequency Regulation from Flexible Loads: Potential, Economics, and Implementation

    E-Print Network [OSTI]

    Sanandaji, Borhan M.

    regulation procurement by as much as 40% [4]. This issue has been recognized in the power and energy system energy capacity into the day-ahead regulation market, and CAISO will dispatch these resources soFrequency Regulation from Flexible Loads: Potential, Economics, and Implementation He Hao1,, Borhan

  18. 01.03 1 Policy & Regulation Manuals REGENTS' POLICY

    E-Print Network [OSTI]

    Pantaleone, Jim

    01.03 1 Policy & Regulation Manuals REGENTS' POLICY PART I ­ MISSION AND GENERAL PROVISIONS Chapter 01.03 ­ Policy and Regulation Manuals P01.03.010. Policies and Regulations; Manuals. A. Policies by the President of the University. Adopted policies shall be maintained in the form of a Policy Manual and set out

  19. Control of Wind Turbines for Power Regulation and

    E-Print Network [OSTI]

    Control of Wind Turbines for Power Regulation and Load Reduction Juan Jose Garcia Quirante Kongens regulation and load reduction and their ensemble in a variable-speed wind turbine. The power regulation aspects of mathematical modelling of wind turbines, and especially the control methods suited for power

  20. MicroRNA Regulation of IGF-1

    E-Print Network [OSTI]

    McEnery, Kayla Anne Filan

    2013-02-04T23:59:59.000Z

    as UNDERGRADUATE RESEARCH SCHOLAR Approved by Research Advisor: Dr. Farida Sohrabji May 2013 Major: Biochemistry Genetics 1 TABLE OF CONTENTS Page TABLE OF CONTENTS??????????????????????????.1 ABSTRACT... an incredible learning experience. Finally, I would like to thank my friends and family for their continuous love and support. 4 ABSTRACT MicroRNA Regulation of IGF. (May 2013) Kayla Anne Filan McEnery Department of Biochemistry & Biophysics Texas A...

  1. CALCIUM SULFATE-INDUCED ACCELERATED CORROSION

    E-Print Network [OSTI]

    Akuezue, Hilary Chikezie

    2013-01-01T23:59:59.000Z

    INDUCED ACCELERATED CORROSION Hilary Chikezie Akuezue (M. S.deposit on Caso 4-induced corrosion. This will involve poreAlso, Caso 4 deposit-induced corrosion will be compared with

  2. Energy-conserving development regulations: current practice

    SciTech Connect (OSTI)

    Not Available

    1980-05-01T23:59:59.000Z

    Almost every aspect of land development has an effect on energy use, from minute architectural details to broad considerations of urban density. Energy-efficiency depends in part on how development is planned and carried out. Conventional development regulations, such as zoning ordinances and subdivision regulations, can be adapted in many ways to promote energy conservation at the community level. This report is about energy-efficient site and neighborhood design. It examines recent experiences of local governments that have adopted new development regulations or amended existing ones to promote energy conservation, more efficient generation and distribution, or a switch to alternative, renewable sources. Although much has been written in recent years about saving energy through community design, actual experience in applying these new ideas is still limited. To date, most communities have focused their efforts on studying the problem, documenting consumption patterns, and writing reports and plans. Only a handful have amended their land-use controls for the express purpose of saving energy. This study identifies 13 of these pioneering communities, after undertaking a survey of over 1400 local, regional, and state planning agencies. It takes a look at their experiences, to learn what has been done, how well it has worked, and what problems have been encountered.

  3. Positive feedback and temperature mediated molecular switch controls differential gene regulation in Bordetella pertussis

    E-Print Network [OSTI]

    Arnab Bandyopadhyay; Suman K. Banik

    2012-08-17T23:59:59.000Z

    Based on the phosphorelay kinetics operative within BvgAS two component system we propose a mathematical framework for signal transduction and gene regulation of phenotypic phases in Bordetella pertussis. The proposed model identifies a novel mechanism of transcriptional interference between two promoters present in the bvg locus. To understand the system behavior under elevated temperature, the developed model has been studied in two different ways. First, a quasi-steady state analysis has been carried out for the two component system, comprising of sensor BvgS and response regulator BvgA. The quasi-steady state analysis reveals temperature induced sharp molecular switch, leading to amplification in the output of BvgA. Accumulation of a large pool of BvgA thus results into differential regulation of the downstream genes, including the gene encoding toxin. Numerical integration of the full network kinetics is then carried out to explore time dependent behavior of different system components, that qualitatively capture the essential features of experimental results performed in vivo. Furthermore, the developed model has been utilized to study mutants that are impaired in their ability to phosphorylate the transcription factor, BvgA, of the signaling network.

  4. INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells

    SciTech Connect (OSTI)

    Min, Joong Won [Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)] [Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Kwang Il [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)] [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Hyun-Ah; Kim, Eun-Kyu; Noh, Woo Chul [Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)] [Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Jeon, Hong Bae [Biomedical Research Institute, MEDIPOST Co., Ltd., Seoul (Korea, Republic of)] [Biomedical Research Institute, MEDIPOST Co., Ltd., Seoul (Korea, Republic of); Cho, Dong-Hyung [Graduate School of East-West Medical Science, Kyung Hee University, Gyeonggi-do (Korea, Republic of)] [Graduate School of East-West Medical Science, Kyung Hee University, Gyeonggi-do (Korea, Republic of); Oh, Jeong Su [Department of Genetic Engineering, Sungkyunkwan University, Suwon (Korea, Republic of)] [Department of Genetic Engineering, Sungkyunkwan University, Suwon (Korea, Republic of); Park, In-Chul; Hwang, Sang-Gu [Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)] [Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Jae-Sung, E-mail: jaesung@kirams.re.kr [Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)] [Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2013-10-11T23:59:59.000Z

    Highlights: HIF-1?-regulated INPP4B enhances glycolysis. INPP4B regulates aerobic glycolysis by inducing HK2 via Akt-mTOR pathway. Blockage of INPP4B and HK2 sensitizes radioresistant laryngeal cancer cells to radiation and anticancer drug. INPP4B is associated with HK2 in human laryngeal cancer tissues. -- Abstract: Inositol polyphosphate 4-phosphatase type II (INPP4B) was recently identified as a tumor resistance factor in laryngeal cancer cells. Herein, we show that INPP4B-mediated resistance is associated with increased glycolytic phenotype. INPP4B expression was induced by hypoxia and irradiation. Intriguingly, overexpression of INPP4B enhanced aerobic glycolysis. Of the glycolysis-regulatory genes, hexokinase 2 (HK2) was mainly regulated by INPP4B and this regulation was mediated through the Akt-mTOR pathway. Notably, codepletion of INPP4B and HK2 markedly sensitized radioresistant laryngeal cancer cells to irradiation or anticancer drug. Moreover, INPP4B was significantly associated with HK2 in human laryngeal cancer tissues. Therefore, these results suggest that INPP4B modulates aerobic glycolysis via HK2 regulation in radioresistant laryngeal cancer cells.

  5. Junction Plasmon-Induced Molecular Reorientation. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Junction Plasmon-Induced Molecular Reorientation. Junction Plasmon-Induced Molecular Reorientation. Abstract: Time and frequency dependent intensity variations in sequences of...

  6. The future of financial markets and regulation: What Strategy for Europe? The Future of Financial Markets and Regulation

    E-Print Network [OSTI]

    Boyer, Edmond

    The future of financial markets and regulation: What Strategy for Europe? 1 The Future of Financial Markets and Regulation: What Strategy for Europe? Jean-Baptiste Goss1 Dominique Plihon2 Abstract This article provides insight into the future of financial markets and regulation in order to define what would

  7. AgriculturAl lAnd ApplicAtion of Biosolids in VirginiA: regulAtions

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    AgriculturAl lAnd ApplicAtion of Biosolids in VirginiA: regulAtions Introduction As required.1-164.5 of the Code of Virginia), which regulate the agricultural use of biosolids in Virginia, were developed to owners of wastewater treatment facilities that land apply their own biosolids. Local governments may

  8. Cell, Vol. 106, 697--708, September 21, 2001, Copyright #2001 by Cell Press Serial Regulation of Transcriptional Regulators

    E-Print Network [OSTI]

    Gifford, David K.

    Cambridge, Massachusetts 02142 extrapolate to regulation of all cell cycle genes. Microarray analysis hasCell, Vol. 106, 697--708, September 21, 2001, Copyright #2001 by Cell Press Serial Regulation of Transcriptional Regulators in the Yeast Cell Cycle (a complex of Swi4 and Swi6) control late G1 genes. Mcm1

  9. Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion

    E-Print Network [OSTI]

    Yandell, Brian S.

    Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin, Boston, Massachusetts, United States of America, 5 Department of Integrative Biology and Physiology participated in the regulation of plasma insulin. We developed a novel ranking scheme based on cross- loci

  10. Evolving Role of the Power Sector Regulator: A Clean Energy Regulators Initiative Report

    SciTech Connect (OSTI)

    Zinaman, O.; Miller, M.; Bazilian, M.

    2014-04-01T23:59:59.000Z

    This paper seeks to briefly characterize the evolving role of power sector regulation. Given current global dynamics, regulation of the power sector is undergoing dramatic changes. This transformation is being driven by various factors including technological advances and cost reductions in renewable energy, energy efficiency, and demand management; increasing air pollution and climate change concerns; and persistent pressure for ensuring sustainable economic development and increased access to energy services by the poor. These issues add to the already complex task of power sector regulation, of which the fundamental remit remains to objectively and transparently ensure least-cost service delivery at high quality. While no single regulatory task is trivial to undertake, it is the prioritization and harmonization of a multitude of objectives that exemplifies the essential challenge of power sector regulation. Evolving regulatory roles can be understood through the concept of existing objectives and an additional layer of emerging objectives. Following this categorization, we describe seven existing objectives of power sector regulators and nine emerging objectives, highlighting key challenges and outlining interdependencies. This essay serves as a preliminary installment in the Clean Energy Regulatory Initiative (CERI) series, and aims to lay the groundwork for subsequent reports and case studies that will explore these topics in more depth.

  11. PES1 regulates sensitivity of colorectal cancer cells to anticancer drugs

    SciTech Connect (OSTI)

    Xie, Wei [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing 100142 (China)] [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing 100142 (China); Qu, Like, E-mail: qulike@bjcancer.org [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing 100142 (China)] [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing 100142 (China); Meng, Lin; Liu, Caiyun; Wu, Jian [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing 100142 (China)] [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing 100142 (China); Shou, Chengchao, E-mail: scc@bjcancer.org [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing 100142 (China)] [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing 100142 (China)

    2013-02-15T23:59:59.000Z

    Highlights: ? PES1 was overexpressed in diverse cancer cell lines. ? PES1-ablation enhances DNA damage response by decreasing DNA repair. ? PES1-ablation increases the sensitivity of HCT116 cells to chemotherapeutic agents. ? PES1-ablation is associated with diminished nuclear entry of RAD51. -- Abstract: PES1 (also known as Pescadillo), a nucleolar protein, was involved in biogenesis of ribosomal RNA. Up-regulation of PES1 has been documented in some human cancers, indicating that PES1 may play some crucial roles in tumorigenesis. In our previous study, it was found that silencing of PES1 resulted in decreased proliferation of colorectal cancer cells. We also noticed that depletion of PES1 altered expression profiles of diverse genes. In the present study, we validated the expression changes of a subset of genotoxic stress-related genes in PES1-silenced HCT116 cells by quantitative RT-PCR. The steady and etoposide-induced phosphorylated H2AX (?-H2AX) were higher in PES1-silenced cells than in control cells. Besides, etoposide-induced ?-H2AX persisted longer in PES1-silenced cells after removing the etoposide. Next, results of comet assay revealed decreased DNA repair after PES1-ablation. PES1-ablated cells were more sensitive to chemotherapeutic agents, which could be reversed by reconstitution with exogenous PES1. Furthermore, deletion of PES1 diminished steady and DNA damage-induced levels of nuclear RAD51. Our results uncover a potential role of PES1 in chemoresistance by regulating DNA damage response in colorectal cancer cells.

  12. Economic Inducement Financing Program (Connecticut)

    Broader source: Energy.gov [DOE]

    Companies relocating to or expanding within the state are eligible for CDA direct loans up to $5 million through its Economic Inducement Financing Program. proceeds may be used for working capital...

  13. Porcine circovirus type 2 replication is impaired by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway

    SciTech Connect (OSTI)

    Wei Li [Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, No.9 Shuguang Garden Central Road, Haidian District, Beijing 100097 (China); Liu Jue [Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, No.9 Shuguang Garden Central Road, Haidian District, Beijing 100097 (China)], E-mail: liujue@263.net

    2009-03-30T23:59:59.000Z

    Postweaning multisystemic wasting syndrome, which is primarily caused by porcine circovirus type 2 (PCV2), is an emerging and important swine disease. We have recently shown that PCV2 induces nuclear factor kappa B activation and its activation is required for active replication, but the other cellular factors involved in PCV2 replication are not well defined. The extracellular signal-regulated kinase (ERK) which served as an important component of cellular signal transduction pathways has been shown to regulate many viral infections. In this report, we show that PCV2 activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication. The PCV2-induced ERK1/2 leads to phosphorylation of the ternary complex factor Elk-1, which kinetically paralleled ERK1/2 activation. Inhibition of ERK activation with U0126, a specific MEK1/2 inhibitor, significantly reduced viral progeny release. Investigations into the mechanism of ERK1/2 regulation revealed that inhibition of ERK activation leads to decreased viral transcription and lower virus protein expression. These data indicate that the ERK signaling pathway is involved in PCV2 infection and beneficial to PCV2 replication in the cultured cells.

  14. Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells

    SciTech Connect (OSTI)

    Kim, Sangmin [Department of Biochemistry, Division of Life Science, College of Natural Sciences, Graduate School of Applied Life Science, Gyeongsang National University, Jinju 660-701 (Korea, Republic of); Pak, Yunbae [Department of Biochemistry, Division of Life Science, College of Natural Sciences, Graduate School of Applied Life Science, Gyeongsang National University, Jinju 660-701 (Korea, Republic of)]. E-mail: ybpak@nongae.gsnu.ac.kr

    2005-04-29T23:59:59.000Z

    The regulatory function of caveolin-2 in cell cycle regulation by insulin was investigated in human insulin receptor-overexpressed rat 1 fibroblast (Hirc-B) cells. Insulin increased induction of the caveolin-2 gene in a time-dependent manner. Direct interaction between ERK and caveolin-2 was confirmed by immunoprecipitation and phosphorylated ERK increased the specific interaction in response to insulin. That insulin induced their nuclear co-localization over time was demonstrated by immunofluorescence microscopy. Insulin increased the S phase in the cell cycle by 6-fold. When recombinant caveolin-1 was transiently expressed, a decrease in the S phase was detected by flow-cytometry. The results indicate that the up-regulation of caveolin-2 in response to insulin activates the downstream signal cascades in the cell cycle, chiefly the increased phosphorylation of ERK, the nuclear translocation of phosphorylated ERK, and the subsequent activation of G0/G1 to S phase transition of the cell cycle. The results also suggest that DNA synthesis and the activation of the cell cycle by insulin are achieved concomitantly with an increase in the interaction between caveolin-2 and phosphorylated ERK, and the nuclear translocation of that complex. Taken together, we conclude that caveolin-2 positively regulates the insulin-induced cell cycle through activation of and direct interaction with ERK in Hirc-B cells.

  15. Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice

    SciTech Connect (OSTI)

    Wang, Jian-Qing [School of Pharmacy, Anhui Medical University, Hefei, 230032 (China) [School of Pharmacy, Anhui Medical University, Hefei, 230032 (China); Second Affiliated Hospital, Anhui Medical University, Hefei 230601 (China); Chen, Xi [First Affiliated Hospital, Anhui Medical University, Hefei 230022 (China)] [First Affiliated Hospital, Anhui Medical University, Hefei 230022 (China); Zhang, Cheng [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China)] [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China); Tao, Li [First Affiliated Hospital, Anhui Medical University, Hefei 230022 (China)] [First Affiliated Hospital, Anhui Medical University, Hefei 230022 (China); Zhang, Zhi-Hui; Liu, Xiao-Qian [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China)] [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China); Xu, Yuan-Bao [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China) [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China); First Affiliated Hospital, Anhui Medical University, Hefei 230022 (China); Wang, Hua [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China)] [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China); Li, Jun, E-mail: lijun@ahmu.edu.cn [School of Pharmacy, Anhui Medical University, Hefei, 230032 (China)] [School of Pharmacy, Anhui Medical University, Hefei, 230032 (China); Xu, De-Xiang, E-mail: xudex@126.com [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China)] [Department of Toxicology, Anhui Medical University, Hefei, 230032 (China)

    2013-01-15T23:59:59.000Z

    A recent report showed that the unfolded protein response (UPR) signaling was activated in the pathogenesis of carbon tetrachloride (CCl{sub 4})-induced hepatic fibrosis. Phenylbutyric acid (PBA) is a well-known chemical chaperone that inhibits endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling. In the present study, we investigated the effects of PBA on CCl{sub 4}-induced hepatic fibrosis in mice. All mice were intraperitoneally (i.p.) injected with CCl{sub 4} (0.15 ml/kg BW, twice per week) for 8 weeks. In CCl{sub 4} + PBA group, mice were i.p. injected with PBA (150 mg/kg, twice per day) from the beginning of CCl{sub 4} injection to the end. As expected, PBA significantly attenuated CCl{sub 4}-induced hepatic ER stress and UPR activation. Although PBA alleviated, only to a less extent, hepatic necrosis, it obviously inhibited CCl{sub 4}-induced tumor necrosis factor alpha (TNF-?) and transforming growth factor beta (TGF-?). Moreover, PBA inhibited CCl{sub 4}-induced hepatic nuclear factor kappa B (NF-?B) p65 translocation and extracellular signal-regulated kinase (ERK) and c-Jun N-terminal Kinase (JNK) phosphorylation. Interestingly, CCl{sub 4}-induced ?-smooth muscle actin (?-SMA), a marker for the initiation phase of HSC activation, was significantly attenuated in mice pretreated with PBA. Correspondingly, CCl{sub 4}-induced hepatic collagen (Col)1?1 and Col1?2, markers for the perpetuation phase of HSC activation, were inhibited in PBA-treated mice. Importantly, CCl{sub 4}-induced hepatic fibrosis, as determined using Sirius red staining, was obviously attenuated by PBA. In conclusion, PBA prevents CCl{sub 4}-induced hepatic fibrosis through inhibiting hepatic inflammatory response and HSC activation. Highlights: ? CCl{sub 4} induces hepatic ER stress, inflammation, HSC activation and hepatic fibrosis. ? PBA alleviates CCl{sub 4}-induced hepatic ER stress and UPR signaling activation. ? PBA inhibits CCl{sub 4}-induced hepatic NF-?B activation and ERK and JNK phosphorylation. ? PBA effectively protects against CCl{sub 4}-induced HSC activation and hepatic fibrosis. ? ER stress is involved in CCl{sub 4}-induced hepatic inflammation and fibrogenesis.

  16. Mechano-growth factor induces migration of rat mesenchymal stem cells by altering its mechanical properties and activating ERK pathway

    SciTech Connect (OSTI)

    Wu, Jiamin; Wu, Kewen; Lin, Feng; Luo, Qing; Yang, Li; Shi, Yisong [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China)] [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Song, Guanbin, E-mail: song@cqu.edu.cn [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China)] [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Sung, Kuo-Li Paul [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China) [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412 (United States)

    2013-11-08T23:59:59.000Z

    Highlights: MGF induced the migration of rat MSC in a concentration-dependent manner. MGF enhanced the mechanical properties of rMSC in inducing its migration. MGF activated the ERK 1/2 signaling pathway of rMSC in inducing its migration. rMSC mechanics may synergy with ERK 1/2 pathway in MGF-induced rMSC migration. -- Abstract: Mechano-growth factor (MGF) generated by cells in response to mechanical stimulation has been identified as a mechano effector molecule, playing a key role in regulating mesenchymal stem cell (MSC) function, including proliferation and migration. However, the mechanism(s) underlying how MGF-induced MSC migration occurs is still unclear. In the present study, MGF motivated migration of rat MSCs (rMSCs) in a concentration-dependent manner and optimal concentration of MGF at 50 ng/mL (defined as MGF treatment in this paper) was demonstrated. Notably, enhancement of mechanical properties that is pertinent to cell migration, such as cell traction force and cell stiffness were found to respond to MGF treatment. Furthermore, MGF increased phosphorylation of extracellular signal-regulated kinase (ERK), ERK inhibitor (i.e., PD98059) suppressed ERK phosphorylation, and abolished MGF-induced rMSC migration were found, demonstrating that ERK is involved molecule for MGF-induced rMSC migration. These in vitro evidences of MGF-induced rMSC migration and its direct link to altering rMSC mechanics and activating the ERK pathway, uncover the underlying biomechanical and biological mechanisms of MGF-induced rMSC migration, which may help find MGF-based application of MSC in clinical therapeutics.

  17. Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells

    SciTech Connect (OSTI)

    Liu, Xiao-Yun; Yang, Yue-Feng; Wu, Chu-Tse; Xiao, Feng-Jun; Zhang, Qun-Wei [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Ma, Xiao-Ni [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Li, Qing-Fang; Yan, Jun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Hua, E-mail: wanghualjh@gmail.com [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Li-Sheng, E-mail: wangls@nic.bmi.ac.cn [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)

    2010-03-19T23:59:59.000Z

    Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are involved in hematogenesises, allergic disorders and tumourigenesis. However, their role in hematologic neoplasms is largely unknown. Possible effects of Spreds on other signal pathways closely related to Ras-ERK have been poorly investigated. In this study, we investigated the in vitro effects of Spred2 on chronic myeloid leukemia (CML) cells. In addition to inhibiting the well-established Ras-ERK cascade, adenovirus-mediated Spred2 over-expression inhibits constitutive and stem cell factor (SCF)-stimulated sphingosine kinase-1 (SPHK1) and Mcl-1 expression, as well as inhibiting proliferation and inducing apoptosis in CML cells. In K562 cells and primary CML cells, imatinib induces endogenous Spred2 expression. Spred2 silencing by stable RNA interference partly protects K562 cells against imatinib-induced apoptosis. Together, these data implicate Spred2 in imatinib-induced cytotoxicity in CML cells, possibly by inhibiting the Ras-ERK cascade and the pro-survival signaling molecules SPHK1 and Mcl-1. These findings reveal potential targets for selective therapy of CML.

  18. Self-regulated gravitational accretion in protostellar discs

    E-Print Network [OSTI]

    E. I. Vorobyov; S. Basu

    2007-09-13T23:59:59.000Z

    We present a numerical model for the evolution of a protostellar disc that has formed self-consistently from the collapse of a molecular cloud core. The global evolution of the disc is followed for several million years after its formation. The capture of a wide range of spatial and temporal scales is made possible by use of the thin-disc approximation. We focus on the role of gravitational torques in transporting mass inward and angular momentum outward during different evolutionary phases of a protostellar disc with disc-to-star mass ratio of order 0.1. In the early phase, when the infall of matter from the surrounding envelope is substantial, mass is transported inward by the gravitational torques from spiral arms that are a manifestation of the envelope-induced gravitational instability in the disc. In the late phase, when the gas reservoir of the envelope is depleted, the distinct spiral structure is replaced by ongoing irregular nonaxisymmetric density perturbations. The amplitude of these density perturbations decreases with time, though this process is moderated by swing amplification aided by the existence of the disc's sharp outer edge. Our global modelling of the protostellar disc reveals that there is typically a residual nonzero gravitational torque from these density perturbations, i.e. their effects do not exactly cancel out in each region. In particular, the net gravitational torque in the inner disc tends to be negative during first several million years of the evolution, while the outer disc has a net positive gravitational torque. Our global model of a self-consistently formed disc shows that it is also self-regulated in the late phase, so that it is near the Toomre stability limit, with a near-uniform Toomre parameter Q\\approx 1.5-2.0. (Abstract abridged).

  19. Regulation changes create opportunities for pipeline manufacturers

    SciTech Connect (OSTI)

    Santon, J.

    1999-09-01T23:59:59.000Z

    The US Department of Transportation`s (DOT) Research and Special Programs Administration (RSPA) is proposing to change its safety standards for the repair of corroded or damaged steel pipe in gas and hazardous liquid pipelines. For pipeline operators, the expected revisions will allow new flexibility in approaches to pipeline repair. Less costly and less disruptive procedures will be acceptable. For manufacturers, the changes will open opportunities for development of corrosion repair technology. A highly competitive market in new repair technology can be expected to arise. Current regulations, new technologies, and proposed safety standards are described.

  20. Self-regulating flow control device

    DOE Patents [OSTI]

    Humphreys, Duane A. (Pittsburgh, PA)

    1984-01-01T23:59:59.000Z

    A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.

  1. Environmental Regulation Impacts on Eastern Interconnection Performance

    SciTech Connect (OSTI)

    Markham, Penn N [ORNL; Liu, Yilu [ORNL; Young II, Marcus Aaron [ORNL

    2013-07-01T23:59:59.000Z

    In the United States, recent environmental regulations will likely result in the removal of nearly 30 GW of oil and coal-fired generation from the power grid, mostly in the Eastern Interconnection (EI). The effects of this transition on voltage stability and transmission line flows have previously not been studied from a system-wide perspective. This report discusses the results of power flow studies designed to simulate the evolution of the EI over the next few years as traditional generation sources are replaced with environmentally friendlier ones such as natural gas and wind.

  2. Property:Regulations | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I GeothermalPotentialBiopowerSolidGenerationMethod Jump to:This property is set byis aRegulations Property

  3. Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism

    SciTech Connect (OSTI)

    Ma, Xiao-Ni [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Liu, Xiao-Yun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China) [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Center for Disease Control and Prevention, Lanzhou Military Command, Lanzhou 730020 (China); Yang, Yue-Feng [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Xiao, Feng-Jun [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Li, Qing-Fang [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Yan, Jun [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Zhang, Qun-Wei; Wang, Li-Sheng [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Li, Xue-Yan, E-mail: llglixueyan@163.com [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Wang, Hua, E-mail: wanghua@bmi.ac.cn [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)

    2011-07-15T23:59:59.000Z

    Highlights: {yields} Hepatocellular carcinoma is inhibited by Spred2 through as yet unclear mechanisms. {yields} We studied the overexpression of Spred2 in cell line and murine tumor models of HCC. {yields} Spred2 inhibited cell proliferation and migration via attenuating ERK signaling. {yields} Spred2 overexpression induced apoptosis via caspase-3 and downregulated Mcl-1. {yields} A Spred2 knockdown markedly induced tumor growth in vivo. -- Abstract: Members of the Spred gene family are negative regulators of the Ras/Raf-1/ERK pathway, which has been associated with several features of the tumor malignancy. However, the effect of Spred genes on hepatocellular carcinoma (HCC) remains uninvestigated. In the present work, we analyzed the in vitro and in vivo effects of Spred2 expression on the hepatic carcinoma cell line, SMMC-7721. In addition to attenuated ERK activation, which inhibited the proliferation and migration of unstimulated and HGF-stimulated SMMC-7721 cells. Adenovirus-mediated Spred2 overexpression induced the activation of caspase-3 and apoptosis, as well as reduced the expression level of Mcl-1. Most importantly, the knockdown of Spred2 markedly enhanced tumor growth in vivo. In conclusion, these results suggest that Spred2 could qualify as a potential therapeutic target in HCC.

  4. Review: Endocrine regulation of placental phenotype

    E-Print Network [OSTI]

    Fowden, A.L.; Forhead, A.J.; Sferruzzi-Perri, A.N.; Burton, G.J.; Vaughan, O.R.

    2014-12-03T23:59:59.000Z

    acids (131, 132). The 221 hormonally induced changes in trophoblast surface area, thickness and vascularity will also 222 influence the passive diffusion properties of the placenta and, hence, transport by simple 223 diffusion of oxygen and waste... 455 pregnancy in the ewe: rates of protein secretion and synthesis and nuclear and cytosol 456 steroid hormone receptor levels. J Endocrinol 1983; 96:137-146. 457 25 Ogle TF Characteristics of high affinity progesterone binding to rat placental...

  5. Regulation of indoor air quality: The last frontier of environmental regulation

    SciTech Connect (OSTI)

    Dickson, R.B. [Paul, Hastings, Janofsky & Walker, Washington, DC (United States)

    1994-12-31T23:59:59.000Z

    Indoor air pollution (IAP) is ranked by the Environmental Protection Agency (EPA) among the top five environmental risks to human health. The World Health Organization estimates that nearly one in every six commercial buildings in the United States suffers from sick-building syndrome and that occupants of another one in twelve suffer from building-related illnesses. Indoor air quality (IAQ) problems cost American business $10 billion per year through lowered productivity, absenteeism, and medical costs. Yet despite the importance and high cost of IAQ problems, indoor air is not yet specifically addressed in any federal regulatory program. The reason probably is because indoor air is a quanitatively different environment in which traditional modes of regulation, based on pollutant-by pollutant risk assessments, are of limited utility. This paper covers the following topics: four factors influencing IAQ regulation; EPA regulation of indoor air; the role of the consumer product safety commission; OSHA and IAQ issues; state regulation and economic concerns; the pressure for legislation.

  6. University Computing Regulations The University of Edinburgh has adopted a set of Regulations to cover the

    E-Print Network [OSTI]

    Koehn, Philipp

    applicable to investigating breaches or suspected breaches are in Regulation 6 below. 2. Private education. All other use is private. Private use is allowed, as a privilege and not a right, but if abused. Damage of computing facilities No person shall, unless appropriately authorised, take any action which

  7. Utility downsizings pose a dilemma for regulators

    SciTech Connect (OSTI)

    Cross, P.S.

    1993-08-01T23:59:59.000Z

    A utility's job-generating potential is critical to most local economies. At the same time, however, high utility employment levels maintain an upward pressure on rates, an effect that does not escape regulators' notice, especially during an economic slowdown. More than on regulator has been heard to say that hard-hit ratepayers should not be called on to support what some may seen as a bloated utility workforce scaled to better times. To complicate things even more, popular cost-cutting goals that include improving productivity and relying more on conservation could mean fewer jobs, at least at the utility. What's more, utility rates play a significant role in how local industries and businesses respond to an economic slowdown. This interplay of economic forces has complicated the ratemaking process. The size of a utility's workforce is an issue of growing significance in rate hearings. Forecasts for test-period salary and wage expenses are less reliable. Early retirement plans promise future savings for ratepayers, but at a cost today.

  8. Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells

    SciTech Connect (OSTI)

    Zeng, Fu-Yue; Dong, Hanqing; Cui, Jimmy; Liu, Lingling [Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 (United States)] [Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 (United States); Chen, Taosheng, E-mail: taosheng.chen@stjude.org [Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 (United States)] [Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 (United States)

    2010-01-01T23:59:59.000Z

    Patients with alveolar rhabdomyosarcoma (ARMS) have poorer response to conventional chemotherapy and lower survival rates than those with embryonal RMS (ERMS). To identify compounds that preferentially block the growth of ARMS, we conducted a small-scale screen of 160 kinase inhibitors against the ARMS cell line Rh30 and ERMS cell line RD and identified inhibitors of glycogen synthase kinase 3 (GSK3), including TWS119 as ARMS-selective inhibitors. GSK3 inhibitors inhibited cell proliferation and induced apoptosis more effectively in Rh30 than RD cells. Ectopic expression of fusion protein PAX3-FKHR in RD cells significantly increased their sensitivity to TWS119. Down-regulation of GSK3 by GSK3 inhibitors or siRNA significantly reduced the transcriptional activity of PAX3-FKHR. These results suggest that GSK3 is directly involved in regulating the transcriptional activity of PAX3-FKHR. Also, GSK3 phosphorylated PAX3-FKHR in vitro, suggesting that GSK3 might regulate PAX3-FKHR activity via phosphorylation. These findings support a novel mechanism of PAX3-FKHR regulation by GSK3 and provide a novel strategy to develop GSK inhibitors as anti-ARMS therapies.

  9. Regulation of methane genes and genome expression

    SciTech Connect (OSTI)

    John N. Reeve

    2009-09-09T23:59:59.000Z

    At the start of this project, it was known that methanogens were Archaeabacteria (now Archaea) and were therefore predicted to have gene expression and regulatory systems different from Bacteria, but few of the molecular biology details were established. The goals were then to establish the structures and organizations of genes in methanogens, and to develop the genetic technologies needed to investigate and dissect methanogen gene expression and regulation in vivo. By cloning and sequencing, we established the gene and operon structures of all of the methane genes that encode the enzymes that catalyze methane biosynthesis from carbon dioxide and hydrogen. This work identified unique sequences in the methane gene that we designated mcrA, that encodes the largest subunit of methyl-coenzyme M reductase, that could be used to identify methanogen DNA and establish methanogen phylogenetic relationships. McrA sequences are now the accepted standard and used extensively as hybridization probes to identify and quantify methanogens in environmental research. With the methane genes in hand, we used northern blot and then later whole-genome microarray hybridization analyses to establish how growth phase and substrate availability regulated methane gene expression in Methanobacterium thermautotrophicus ?H (now Methanothermobacter thermautotrophicus). Isoenzymes or pairs of functionally equivalent enzymes catalyze several steps in the hydrogen-dependent reduction of carbon dioxide to methane. We established that hydrogen availability determine which of these pairs of methane genes is expressed and therefore which of the alternative enzymes is employed to catalyze methane biosynthesis under different environmental conditions. As were unable to establish a reliable genetic system for M. thermautotrophicus, we developed in vitro transcription as an alternative system to investigate methanogen gene expression and regulation. This led to the discovery that an archaeal protein, designated TFE, that had sequences in common with the eukaryotic general transcription factor TFIIE, stimulated archaeal transcription initiation and that the archaeal TATA-box binding protein (TBP) remained attached to the promoter region whereas the transcription factor TFB dissociated from the template DNA following initiation. DNA sequences that directed the localized assembly of archaeal histones into archaeal nucleosomes were identified, and we established that transcription by an archaeal RNA polymerase was slowed but not blocked by archaeal nucleosomes. We developed a new protocol to purify archaeal RNA polymerases and with this enzyme and additional improvements to the in vitro transcription system, we established the template requirements for archaeal transcription termination, investigated the activities of proteins predicted to be methane gene regulators, and established how TrpY, a novel archaeal regulator of expression of the tryptophan biosynthetic operon functions in M. thermautotrophicus. This also resulted in the discovery that almost all M. thermautotrophicus mutants isolated as spontaneously resistant to 5-methyl tryptophan (5MTR) had mutations in trpY and were therefore 5MTR through de-repressed trp operon expression. This established a very simple, practical procedure to determine and quantify the DNA sequence changes that result from exposure of this Archaeon to any experimental mutagenesis protocol. Following the discovery that the Thermococcus kodakaraensis was amenable to genetic manipulation, we established this technology at OSU and subsequently added plasmid expression, a reporter system and additional genetic selections to the T. kodakaraensis genetic toolbox. We established that transcription and translation are coupled in this Archaeon, and by combining in vitro transcription and in vivo genetics, we documented that both TFB1 and TFB2 support transcription initiation in T. kodakaraensis. We quantified the roles of ribosome binding sequences and alternative initiation codons in translation initiation, established that polarity e

  10. Control and regulation of modern distribution system, ForskEL...

    Open Energy Info (EERE)

    system, ForskEL (Smart Grid Project) Jump to: navigation, search Project Name Control and regulation of modern distribution system, ForskEL Country Denmark Coordinates...

  11. administration regulations based: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    regulation when damages vary across sources: What are the gains from differentiation? Power Transmission, Distribution and Plants Websites Summary: For much of the air pollution...

  12. Air Pollution Control Regulations: No. 7 - Emission of Air Contaminant...

    Broader source: Energy.gov (indexed) [DOE]

    with the enjoyment of life and property. The criteria for determining compliance is listed in the regulations, and is based on other air pollution and ambient air standards...

  13. Effective Regulatory Institutions: The Regulator's Role in the...

    Open Energy Info (EERE)

    Institutions: The Regulator's Role in the Policy Process, Including Issues of Regulatory Independence Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Effective...

  14. Goodyear's Self-Regulating Tires Save Fuel, Improve Safety, Win...

    Energy Savers [EERE]

    on the environment. Addthis Related Articles This graphic shows how Goodyear's new Air Maintenance Technology -- also called the self-regulating tire -- works. | Graphic...

  15. Evolutionary-Economic Principles as Regulators of Soil Enzyme Production

    E-Print Network [OSTI]

    German, Donovan P.

    Chapter 12 Evolutionary-Economic Principles as Regulators of Soil Enzyme Production and Ecosystem (chitinases), organic phosphates (phosphatases), and lignins (oxidases, peroxidases) (Burns 1978; Allison et

  16. automatic regulator voltage: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rouzbahan 2013-01-01 12 Optimal Distributed Voltage Regulation in Power Distribution Networks CERN Preprints Summary: In this paper, we address the problem of voltage...

  17. Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A - General Provisions Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A - General Provisions The...

  18. The regulation of internet interconnection : assessing network market power

    E-Print Network [OSTI]

    Maida, Elisabeth M. (Elisabeth Marigo)

    2013-01-01T23:59:59.000Z

    Interconnection agreements in the telecommunications industry have always been constrained by regulation. Internet interconnection has not received the same level of scrutiny. Recent debates regarding proposed mergers, ...

  19. Standards for Municipal Small Wind Regulations and Model Ordinance

    Broader source: Energy.gov [DOE]

    In July 2008, New Hampshire enacted legislation designed to prevent municipalities from adopting ordinances or regulations that place unreasonable limits on or hinder the performance of wind energy...

  20. Council on Environmental Quality (CEQ) NEPA Regulations: 40 CFR...

    Open Energy Info (EERE)

    to library Legal Document- Secondary Legal SourceSecondary Legal Source: Council on Environmental Quality (CEQ) NEPA Regulations: 40 CFR 1500 - 1518Legal Author CEQ Published NA...