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Sample records for upward regulation effect

  1. Activation of 200 MW refusegenerated CHP upward regulation effect...

    Open Energy Info (EERE)

    EU Smart Grid Projects Map1 Overview Waste CHP plants can be used in the electricity market for upward regulation by bypassing the steam turbine. The technical design for this...

  2. Activation of 200 MW refusegenerated CHP upward regulation effect...

    Open Energy Info (EERE)

    regulation effect Country Denmark Headquarters Location Thisted, Denmark Coordinates 56.959167, 8.703492 Loading map... "minzoom":false,"mappingservice":"googlemaps3","typ...

  3. Effects of Increased Upward Flux of Saline Water Caused by CO2 Storage or Other Factors

    SciTech Connect (OSTI)

    Murdoch, Lawrence; Xie, Shuang; Falta, Ronald W.; Yonkofski, Catherine MR

    2015-08-01

    Injection of CO2 in deep saline aquifers is being considered to reduce greenhouse gases in the atmosphere, and this process is expected to increase the pressure in these deep aquifers. One potential consequence of pressurization is an increase in the upward flux of saline water. Saline groundwater occurs naturally at shallow depths in many sedimentary basins, so an upward flux of solutes could degrade the quality of freshwater aquifers and threaten aquatic ecosystems. One problem could occur where saline water flowed upward along preferential paths, like faults or improperly abandoned wells. Diffuse upward flow through the natural stratigraphy could also occur in response to basin pressurization. This process would be slower, but diffuse upward flow could affect larger areas than flow through preferential paths, and this motivated us to evaluate this process. We analyzed idealized 2D and 3D geometries representing the essential details of a shallow, freshwater aquifer underlain by saline ground water in a sedimentary basin. The analysis was conducted in two stages, one that simulated the development of a freshwater aquifer by flushing out saline water, and another that simulated the effect of a pulse-like increase in the upward flux from the basin. The results showed that increasing the upward flux from a basin increased the salt concentration and mass loading of salt to streams, and decrease the depth to the fresh/salt transition. The magnitude of these effects varied widely, however, from a small, slow process that would be challenging to detect, to a large, rapid response that could be an environmental catastrophe. The magnitude of the increased flux, and the initial depth to the fresh/salt transition in groundwater controlled the severity of the response. We identified risk categories for salt concentration, mass loading, and freshwater aquifer thickness, and we used these categories to characterize the severity of the response. This showed that risks would likely be minor if the upward flux was smaller than a few tenths of the magnitude of recharge, according to the 2D analyses. The 3D analyses also show that upward flux could occur without a significant increase in the risk categories. The major contribution of this work is that it shows how a large increase in diffuse upward flux from a basin could cause significant problems, but a small increase in upward flux may occur without significantly affecting risks to the shallow freshwater flow system. This heightens the importance of understanding interactions between shallow and deep hydrologic systems when characterizing CO2 storage projects.

  4. Effect of ignition conditions on upward flame spread on a composite material in a corner configuration

    SciTech Connect (OSTI)

    Ohlemiller, T.; Cleary, T.; Shields, J.

    1996-12-31

    This paper focuses on the issue of fire growth on composite materials beyond the region immediately subjected to an ignition source. Suppression of this growth is one of the key issues in realizing the safe usage of composite structural materials. A vinyl ester/glass composite was tested in the form of a 90{degrees} comer configuration with an inert ceiling segment 2.44 m above the top of the fire source. The igniter was a propane burner, either 23 or 38 cm in width with power output varied from 30 to 150 Kw. Upward flame spread rate and heat release rate were measured mainly for a brominated vinyl ester resin but limited results were also obtained for a non-flame retarded vinyl ester and a similar composite coated with an intumescent paint. Rapid fire growth beyond the igniter region was seen for the largest igniter power case; the intumescent coating successfully prevented fire growth for this case.

  5. DOE Review of Regulations - Center for Regulatory Effectiveness Comments |

    Energy Savers [EERE]

    Department of Energy Review of Regulations - Center for Regulatory Effectiveness Comments DOE Review of Regulations - Center for Regulatory Effectiveness Comments The Center for Regulatory Effectiveness (CRE) is pleased to submit these comments to the Department of Energy (DOE) on how DOE can best review its existing regulations and to identify whether any of its existing regulations should be modified, streamlined, expanded or repealed. PDF icon

  6. A Simpler, Smarter and More Cost Effective Approach to Regulation |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy A Simpler, Smarter and More Cost Effective Approach to Regulation A Simpler, Smarter and More Cost Effective Approach to Regulation May 26, 2011 - 9:17am Addthis Sean Lev Sean Lev Acting General Counsel & Deputy General Counsel, Environment & Nuclear Programs What does this mean for me? The Department projects a more than 90% reduction in the paperwork burden imposed on recipients of the Department of Energy's financial assistance. The Department is also working

  7. Sources of biogenic methane to form marine gas hydrates: In situ production or upward migration?

    SciTech Connect (OSTI)

    Paull, C.K.; Ussler, W. III; Borowski, W.S.

    1993-09-01

    Potential sources of biogenic methane in the Carolina Continental Rise -- Blake Ridge sediments have been examined. Two models were used to estimate the potential for biogenic methane production: (1) construction of sedimentary organic carbon budgets, and (2) depth extrapolation of modern microbial production rates. While closed-system estimates predict some gas hydrate formation, it is unlikely that >3% of the sediment volume could be filled by hydrate from methane produced in situ. Formation of greater amounts requires migration of methane from the underlying continental rise sediment prism. Methane may be recycled from below the base of the gas hydrate stability zone by gas hydrate decomposition, upward migration of the methane gas, and recrystallization of gas hydrate within the overlying stability zone. Methane bubbles may also form in the sediment column below the depth of gas hydrate stability because the methane saturation concentration of the pore fluids decreases with increasing depth. Upward migration of methane bubbles from these deeper sediments can add methane to the hydrate stability zone. From these models it appears that recycling and upward migration of methane is essential in forming significant gas hydrate concentrations. In addition, the depth distribution profiles of methane hydrate will differ if the majority of the methane has migrated upward rather than having been produced in situ.

  8. Effective Regulatory Institutions: The Regulator's Role in the...

    Open Energy Info (EERE)

    Regulatory Institutions: The Regulator's Role in the Policy Process, Including Issues of Regulatory Independence Jump to: navigation, search Tool Summary LAUNCH TOOL Name:...

  9. Experimental investigation on heat transfer and frictional characteristics of vertical upward rifled tube in supercritical CFB boiler

    SciTech Connect (OSTI)

    Yang, Dong; Pan, Jie; Zhu, Xiaojing; Bi, Qincheng; Chen, Tingkuan; Zhou, Chenn Q.

    2011-02-15

    Water wall design is a key issue for supercritical Circulating Fluidized Bed (CFB) boiler. On account of the good heat transfer performance, rifled tube is applied in the water wall design of a 600 MW supercritical CFB boiler in China. In order to investigate the heat transfer and frictional characteristics of the rifled tube with vertical upward flow, an in-depth experiment was conducted in the range of pressure from 12 to 30 MPa, mass flux from 230 to 1200 kg/(m{sup 2} s), and inner wall heat flux from 130 to 720 kW/m{sup 2}. The wall temperature distribution and pressure drop in the rifled tube were obtained in the experiment. The normal, enhanced and deteriorated heat transfer characteristics were also captured. In this paper, the effects of pressure, inner wall heat flux and mass flux on heat transfer characteristics are analyzed, the heat transfer mechanism and the frictional resistance performance are discussed, and the corresponding empirical correlations are presented. The experimental results show that the rifled tube can effectively prevent the occurrence of departure from nucleate boiling (DNB) and keep the tube wall temperature in a permissible range under the operating condition of supercritical CFB boiler. (author)

  10. The effects of air pollution regulations on the US refining industry. Task 3

    SciTech Connect (OSTI)

    Not Available

    1989-06-01

    Numerous air pollution regulations affecting petroleum refineries recently have been promulgated, have been proposed, or are under consideration at the federal, state, and local level. As shown in Figure ES-1, all of these environmental regulations are intended to take effect over the relatively short time period from 1989 through 1995. In the aggregate these regulatory activities have significant implications for the US refining industry and the Nation, including: Major investment requirements; changes in industry profitability; potential closure of some refineries; and potential changes in crude oil or product import dependence. At issue is whether the cumulative effect of these regulations could so adversely affect the US refining industry that US national security would be affected. In addition to the regulations outlined in Figure ES-1, President Bush recently presented a major new plan to improve the nation`s air quality. The aspects of the President`s plan that could strongly affect US refineries are summarized below.

  11. Relativistic self-focusing of ultra-high intensity X-ray laser beams in warm quantum plasma with upward density profile

    SciTech Connect (OSTI)

    Habibi, M.; Ghamari, F.

    2014-05-15

    The results of a numerical study of high-intensity X-ray laser beam interaction with warm quantum plasma (WQP) are presented. By means of an upward ramp density profile combined with quantum factors specially the Fermi velocity, we have demonstrated significant relativistic self-focusing (RSF) of a Gaussian electromagnetic beam in the WQP where the Fermi temperature term in the dielectric function is important. For this purpose, we have considered the quantum hydrodynamics model that modifies refractive index of inhomogeneous WQPs with the inclusion of quantum correction through the quantum statistical and diffraction effects in the relativistic regime. Also, to better illustration of the physical difference between warm and cold quantum plasmas and their effect on the RSF, we have derived the envelope equation governing the spot size of X-ray laser beam in Q-plasmas. In addition to the upward ramp density profile, we have found that the quantum effects would be caused much higher oscillation and better focusing of X-ray laser beam in the WQP compared to that of cold quantum case. Our computational results reveal the importance of the use of electrons density profile and Fermi speed in enhancing self-focusing of laser beam.

  12. Market effects of environmental regulation: coal, railroads, and the 1990 Clean Air Act

    SciTech Connect (OSTI)

    Busse, M.R.; Keohane, N.O.

    2007-01-01

    Many environmental regulations encourage the use of 'clean' inputs. When the suppliers of such an input have market power, environmental regulation will affect not only the quantity of the input used but also its price. We investigate the effect of the Title IV emissions trading program for sulfur dioxide on the market for low-sulfur coal. We find that the two railroads transporting coal were able to price discriminate on the basis of environmental regulation and geographic location. Delivered prices rose for plants in the trading program relative to other plants, and by more at plants near a low-sulfur coal source.

  13. The detection of upwardly propagating waves channeling energy from the chromosphere to the low corona

    SciTech Connect (OSTI)

    Freij, N.; Nelson, C. J.; Mumford, S.; Erdlyi, R.; Scullion, E. M.; Wedemeyer, S.

    2014-08-10

    There have been ubiquitous observations of wave-like motions in the solar atmosphere for decades. Recent improvements to space- and ground-based observatories have allowed the focus to shift to smaller magnetic structures on the solar surface. In this paper, high-resolution ground-based data taken using the Swedish 1 m Solar Telescope is combined with co-spatial and co-temporal data from the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO) satellite to analyze running penumbral waves (RPWs). RPWs have always been thought to be radial wave propagation that occurs within sunspots. Recent research has suggested that they are in fact upwardly propagating field-aligned waves (UPWs). Here, RPWs within a solar pore are observed for the first time and are interpreted as UPWs due to the lack of a penumbra that is required to support RPWs. These UPWs are also observed co-spatially and co-temporally within several SDO/AIA elemental lines that sample the transition region and low corona. The observed UPWs are traveling at a horizontal velocity of around 17 0.5 km s{sup 1} and a minimum vertical velocity of 42 21 km s{sup 1}. The estimated energy of the waves is around 150 W m{sup 2}, which is on the lower bound required to heat the quiet-Sun corona. This is a new, yet unconsidered source of wave energy within the solar chromosphere and low corona.

  14. Experimental study of forced convection heat transfer during upward and downward flow of helium at high pressure and high temperature

    SciTech Connect (OSTI)

    Francisco Valentin; Narbeh Artoun; Masahiro Kawaji; Donald M. McEligot

    2015-08-01

    Fundamental high pressure/high temperature forced convection experiments have been conducted in support of the development of a Very High Temperature Reactor (VHTR) with a prismatic core. The experiments utilize a high temperature/high pressure gas flow test facility constructed for forced convection and natural circulation experiments. The test section has a single 16.8 mm ID flow channel in a 2.7 m long, 108 mm OD graphite column with four 2.3kW electric heater rods placed symmetrically around the flow channel. This experimental study presents the role of buoyancy forces in enhancing or reducing convection heat transfer for helium at high pressures up to 70 bar and high temperatures up to 873 degrees K. Wall temperatures have been compared among 10 cases covering the inlet Re numbers ranging from 500 to 3,000. Downward flows display higher and lower wall temperatures in the upstream and downstream regions, respectively, than the upward flow cases due to the influence of buoyancy forces. In the entrance region, convection heat transfer is reduced due to buoyancy leading to higher wall temperatures, while in the downstream region, buoyancyinduced mixing causes higher convection heat transfer and lower wall temperatures. However, their influences are reduced as the Reynolds number increases. This experimental study is of specific interest to VHTR design and validation of safety analysis codes.

  15. Methods and apparatus to produce stick-slip motion of logging tool attached to a wireline drawn upward by a continuously rotating wireline drum

    DOE Patents [OSTI]

    Vail, III, William Banning (Bothell, WA); Momii, Steven Thomas (Seattle, WA)

    1998-01-01

    Methods and apparatus are described to produce stick-slip motion of a logging tool within a cased well attached to a wireline that is drawn upward by a continuously rotating wireline drum. The stick-slip motion results in the periodic upward movement of the tool in the cased well described in terms of a dwell time during which time the tool is stationary, the move time during which time the tool moves, and the stroke that is upward distance that the tool translates during the "slip" portion of the stick-slip motion. This method of measurement is used to log the well at different vertical positions of the tool. Therefore, any typical "station-to-station logging tool" may be modified to be a "continuous logging tool", where "continuous" means that the wireline drum continually rotates while the tool undergoes stick-slip motion downhole and measurements are performed during the dwell times when the tool is momentarily stationary. The stick-slip methods of operation and the related apparatus are particularly described in terms of making measurements of formation resistivity from within a cased well during the dwell times when the tool is momentarily stationary during the periodic stick-slip motion of the logging tool.

  16. Methods and apparatus to produce stick-slip motion of logging tool attached to a wireline drawn upward by a continuously rotating wireline drum

    DOE Patents [OSTI]

    Vail, W.B. III; Momii, S.T.

    1998-02-10

    Methods and apparatus are described to produce stick-slip motion of a logging tool within a cased well attached to a wireline that is drawn upward by a continuously rotating wireline drum. The stick-slip motion results in the periodic upward movement of the tool in the cased well described in terms of a dwell time during which time the tool is stationary, the move time during which time the tool moves, and the stroke that is upward distance that the tool translates during the ``slip`` portion of the stick-slip motion. This method of measurement is used to log the well at different vertical positions of the tool. Therefore, any typical ``station-to-station logging tool`` may be modified to be a ``continuous logging tool,`` where ``continuous`` means that the wireline drum continually rotates while the tool undergoes stick-slip motion downhole and measurements are performed during the dwell times when the tool is momentarily stationary. The stick-slip methods of operation and the related apparatus are particularly described in terms of making measurements of formation resistivity from within a cased well during the dwell times when the tool is momentarily stationary during the periodic stick-slip motion of the logging tool. 12 figs.

  17. Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop

    SciTech Connect (OSTI)

    Lai, Serene R.; Cunningham, Amanda P.; Huynh, Vu Q.; Andrews, Lucy G.; Tollefsbol, Trygve O. . E-mail: trygve@uab.edu

    2007-01-15

    The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme telomerase which is responsible for telomeric maintenance and extension. Using RNA interference to knock down hTERT mRNA expression, we provide evidence that hTERT exerts extra-telomeric effects on the cell cycle and on its own regulatory proteins, specifically: p53 and p21. We tested our hypothesis that hTERT regulates its own expression through effects on upstream regulatory genes using transformed human embryonic kidney (HEK 293) cells, p53 and p16 {sup INK4a} null human ovarian cancer SKOV-3 cells, and p53-null MDA-MB-157 human mammary cancer cells. In HEK 293 cells, hTERT knockdown resulted in elevated p53 and p21 transcription and a decrease in cellular proliferation. Similar results were observed in the MDA-MB-157 cell line where p21 was upregulated, correlating with cell growth inhibition. In contrast, we observed a decrease in expression of p21 in SKOV-3 cells with hTERT knockdown and cell growth appeared to be unaffected. These findings suggest that hTERT may be involved in a feedback loop system, thereby playing a role in its own regulation.

  18. Regulation of brain copper homeostasis by the brain barrier systems: Effects of Fe-overload and Fe-deficiency

    SciTech Connect (OSTI)

    Monnot, Andrew D.; Behl, Mamta; Ho, Sanna; Zheng, Wei

    2011-11-15

    Maintaining brain Cu homeostasis is vital for normal brain function. The role of systemic Fe deficiency (FeD) or overload (FeO) due to metabolic diseases or environmental insults in Cu homeostasis in the cerebrospinal fluid (CSF) and brain tissues remains unknown. This study was designed to investigate how blood-brain barrier (BBB) and blood-SCF barrier (BCB) regulated Cu transport and how FeO or FeD altered brain Cu homeostasis. Rats received an Fe-enriched or Fe-depleted diet for 4 weeks. FeD and FeO treatment resulted in a significant increase (+ 55%) and decrease (- 56%) in CSF Cu levels (p < 0.05), respectively; however, neither treatment had any effect on CSF Fe levels. The FeD, but not FeO, led to significant increases in Cu levels in brain parenchyma and the choroid plexus. In situ brain perfusion studies demonstrated that the rate of Cu transport into the brain parenchyma was significantly faster in FeD rats (+ 92%) and significantly slower (- 53%) in FeO rats than in controls. In vitro two chamber Transwell transepithelial transport studies using primary choroidal epithelial cells revealed a predominant efflux of Cu from the CSF to blood compartment by the BCB. Further ventriculo-cisternal perfusion studies showed that Cu clearance by the choroid plexus in FeD animals was significantly greater than control (p < 0.05). Taken together, our results demonstrate that both the BBB and BCB contribute to maintain a stable Cu homeostasis in the brain and CSF. Cu appears to enter the brain primarily via the BBB and is subsequently removed from the CSF by the BCB. FeD has a more profound effect on brain Cu levels than FeO. FeD increases Cu transport at the brain barriers and prompts Cu overload in the CNS. The BCB plays a key role in removing the excess Cu from the CSF.

  19. AN INDIRECT SEARCH FOR WEAKLY INTERACTING MASSIVE PARTICLES IN THE SUN USING 3109.6 DAYS OF UPWARD-GOING MUONS IN SUPER-KAMIOKANDE

    SciTech Connect (OSTI)

    Tanaka, T.; Abe, K.; Hayato, Y.; Iida, T.; Kameda, J.; Koshio, Y.; Kouzuma, Y.; Miura, M.; Moriyama, S.; Nakahata, M.; Nakayama, S.; Obayashi, Y.; Sekiya, H.; Shiozawa, M.; Suzuki, Y.; Takeda, A.; Takenaga, Y.; Ueno, K.; Ueshima, K.; Yamada, S.; Collaboration: Super-Kamiokande Collaboration; and others

    2011-12-01

    We present the result of an indirect search for high energy neutrinos from Weakly Interacting Massive Particle (WIMP) annihilation in the Sun using upward-going muon (upmu) events at Super-Kamiokande. Data sets from SKI-SKIII (3109.6 days) were used for the analysis. We looked for an excess of neutrino signal from the Sun as compared with the expected atmospheric neutrino background in three upmu categories: stopping, non-showering, and showering. No significant excess was observed. The 90% C.L. upper limits of upmu flux induced by WIMPs of 100 GeV c{sup -2} were 6.4 Multiplication-Sign 10{sup -15} cm{sup -2} s{sup -1} and 4.0 Multiplication-Sign 10{sup -15} cm{sup -2} s{sup -1} for the soft and hard annihilation channels, respectively. These limits correspond to upper limits of 4.5 Multiplication-Sign 10{sup -39} cm{sup -2} and 2.7 Multiplication-Sign 10{sup -40} cm{sup -2} for spin-dependent WIMP-nucleon scattering cross sections in the soft and hard annihilation channels, respectively.

  20. Down-regulation of gibberellic acid in poplar has negligible effects on host-plant suitability and insect pest response

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Buhl, Christine; Strauss, Steven H.; Lindroth, Richard L.

    2015-01-06

    Abstract Endogenous levels and signaling of gibberellin plant hormones such as gibberellic acid (GA) have been genetically down-regulated to create semi-dwarf varieties of poplar. The potential benefits of semi-dwarf stature include reduced risk of wind damage, improved stress tolerance, and improved wood quality. Despite these benefits, modification of growth traits may have consequences for non-target traits that confer defense against insect herbivores. According to the growth-differentiation balance hypothesis, reductions in growth may shift allocation of carbon from growth to chemical resistance traits, thereby altering plant defense. To date, host-plant suitability and pest response have not been comprehensively evaluated in GAmore » down-regulated plants. We quantified chemical resistance and nitrogen (an index of protein) in GA down-regulated and wild-type poplar (Populus alba × P. tremula) genotypes. We also evaluated performance of both generalist (Lymantria dispar) and specialist (Chrysomela scripta) insect pests reared on these genotypes. Our evaluation of resistance traits in four GA down-regulated genotypes revealed increased phenolic glycosides in one modified genotype and reduced lignin in two modified genotypes relative to the non-transgenic wild type. Nitrogen levels did not vary significantly among the experimental genotypes. Generalists reared on the four GA down-regulated genotypes exhibited reduced performance on only one modified genotype relative to the wild type. Specialists, however, performed similarly across all genotypes. Results from this study indicate that although some non-target traits varied among GA down-regulated genotypes, the differences in poplar pest susceptibility were modest and highly genotype-specific.« less

  1. Down-regulation of gibberellic acid in poplar has negligible effects on host-plant suitability and insect pest response

    SciTech Connect (OSTI)

    Buhl, Christine; Strauss, Steven H.; Lindroth, Richard L.

    2015-01-06

    Abstract Endogenous levels and signaling of gibberellin plant hormones such as gibberellic acid (GA) have been genetically down-regulated to create semi-dwarf varieties of poplar. The potential benefits of semi-dwarf stature include reduced risk of wind damage, improved stress tolerance, and improved wood quality. Despite these benefits, modification of growth traits may have consequences for non-target traits that confer defense against insect herbivores. According to the growth-differentiation balance hypothesis, reductions in growth may shift allocation of carbon from growth to chemical resistance traits, thereby altering plant defense. To date, host-plant suitability and pest response have not been comprehensively evaluated in GA down-regulated plants. We quantified chemical resistance and nitrogen (an index of protein) in GA down-regulated and wild-type poplar (Populus alba P. tremula) genotypes. We also evaluated performance of both generalist (Lymantria dispar) and specialist (Chrysomela scripta) insect pests reared on these genotypes. Our evaluation of resistance traits in four GA down-regulated genotypes revealed increased phenolic glycosides in one modified genotype and reduced lignin in two modified genotypes relative to the non-transgenic wild type. Nitrogen levels did not vary significantly among the experimental genotypes. Generalists reared on the four GA down-regulated genotypes exhibited reduced performance on only one modified genotype relative to the wild type. Specialists, however, performed similarly across all genotypes. Results from this study indicate that although some non-target traits varied among GA down-regulated genotypes, the differences in poplar pest susceptibility were modest and highly genotype-specific.

  2. Effect on the condition of the metal in A K-300-3.5 turbine owing to multicycle fatigue from participation of a power generating unit in grid frequency and power regulation

    SciTech Connect (OSTI)

    Lebedeva, A. I.; Zorchenko, N. V.; Prudnikov, A. A.

    2011-09-15

    The effect on the condition of the rotor material owing to multicycle fatigue caused by variable stresses during participation of a power generating unit in grid frequency and power regulation is evaluated using the K-300-23.5 steam turbine as an example. It is shown that during normalized primary frequency regulation the safety factor is at least 50, while during automatic secondary regulation of frequency and power there is essentially no damage to the metal.

  3. Regulations | Department of Energy

    Energy Savers [EERE]

    Information Center » Regulations Regulations Personnel Security Regulations Click Here FOIA Regulations Click Here Privacy Act Regulations Click Here Whistleblower Protection Regulations Click Here Exception Regulations Click Here Procedural Regulations Click Here Browse Title 10 Energy Regulations Click Here Annual Reports Filing Information FOIA Decisions Security Hearings Decisions Whistleblower Decisions EIA Decisions Oil Refund Decisions Product Efficiency Decisions Decision Summaries

  4. Acquisition Regulation

    Energy Savers [EERE]

    6 Rev. 1 Date 09/09/2015 Department of Energy No. FAL 2015-04 Rev. 1 Date 09/09/2015 Financial Assistance Regulations ACQUISITION/FINANCIAL ASSISTANCE LETTER This Acquisition/Financial Assistance Letter is issued under the authority of the Senior Procurement Executive of DOE. It is intended for use by procurement professionals of DOE, primarily Contracting Officers, and other officials of DOE that are involved in the acquisition process. Other parties are welcome to its information, but

  5. Reviving regulation - and antitrust

    SciTech Connect (OSTI)

    Shepherd, W.G.

    1994-06-01

    The ills of utility regulation have been overstated by interested players and at least some academics. One can have the best features of both competition and regulation by a paradigm that combines some regulation with stronger antitrust enforcement. It is now obvious that the success of deregulation actually depends crucially on whether antitrust policy is effective in preventing monopoly. In fact, antitrust policies have been extremely weak since 1980, under a deliberate Reagan administration withdrawal of enforcement. Where deregulation has led to market dominance, which antitrust cannot well cure, the policy changes of the 1980`s may have created costly and irreversible mistakes in a number of major sectors. Yet fast-paced events are currently creating a frenzy of even more deregulation, supposedly to fit new {open_quotes}revolutions{close_quotes} in technology and the impacts of large mergers. Instead it is time for particular caution in electricity.

  6. Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations Regulations Security Reviews Click Here FOIA Appeals Click Here Whistleblower Protection Click Here Procedural Regulations Click Here Browse Title 10 Energy Click Here

  7. Acquisition Regulation

    Energy Savers [EERE]

    .1 * * ~, No. AL-2015-09 Date August 25, 2015 fJ~ ~* - . *--~o' 1 '.j ! t :i ?';; * ~~* ~'~"l'ES'ffito":J ACQUISITION LETTER This Acquisition Letter is issued under the authority of the Senior Procurement Executives of DOE and NNSA Subject: Conference Related Activities and Spending References: Deputy Secretary Memorandum of 8/ 17I15 When is this Acquisition Letter (AL) effective? This AL is effective immediately upon issuance. When does this AL expire? Updated Guidance on Conference-

  8. Charge regulation circuit

    DOE Patents [OSTI]

    Ball, Don G. (Livermore, CA)

    1992-01-01

    A charge regulation circuit provides regulation of an unregulated voltage supply in the range of 0.01%. The charge regulation circuit is utilized in a preferred embodiment in providing regulated voltage for controlling the operation of a laser.

  9. Acquisition Regulation

    Broader source: Energy.gov (indexed) [DOE]

    5 Date 05/12/2015 ACQUISITION LETTER This Acquisition Letter is issued under the authority of the DOE and NNSA Senior Procurement Executives. Acquisition Letters (AL) that remain in effect are identified below. All other previously issued ALs have been superseded by a formal rule-making, incorporated into other guidance, and/or canceled. ** ************** ACQUISITION LETTERS REMAINING IN EFFECT NUMBER DATE SUBJECT 93-4 04/07/1993 Displaced Workers Benefits Program 94-19 12/09/1994 Basic Labor

  10. Acquisition Regulation

    Energy Savers [EERE]

    8 August 24, 2015 ACQUISITION LETTER This Acquisition Letter is issued under the authority of the Senior Procurement Executives of DOE and NNSA. It is intended for use by procurement professionals of DOE and NNSA, primarily Contracting Officers, and other officials of DOE and NNSA that are involved in the acquisition process. Other parties are welcome to its information, but definitive interpretations of its effect on contracts, and related procedures, if any, may only be made by DOE NNSA

  11. Regulators, Requirements, Statutes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulators, Requirements, Statutes Regulators, Requirements, Statutes The Laboratory must comply with environmental laws and regulations that apply to Laboratory operations. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email Environmental laws and regulations LANL complies with more than 30 state and federal regulations and policies designed to protect human health and the environment. Regulators Regulators Environmental

  12. Guidance Regarding NEPA Regulations | Department of Energy

    Office of Environmental Management (EM)

    NEPA Regulations Guidance Regarding NEPA Regulations This document provides Council on Environmental Quality guidance on several topics: scoping, categorical exclusions, adoption procedures, contracting provisions, selection of alternatives in licensing and permitting situations, and tiering. PDF icon Guidance Regarding NEPA Regulations More Documents & Publications Final Guidance for Effective Use of Programmatic NEPA Review Forty Most Asked Questions Concerning CEQ's National Environmental

  13. Regulations for Implementing the Procedural Provisions of NEPA | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Regulations for Implementing the Procedural Provisions of NEPA Regulations for Implementing the Procedural Provisions of NEPA PDF icon CEQ Regulations for Implementing the Procedural Provisions of NEPA (40 CFR 1500-1508) More Documents & Publications Effective Public Participation Forty Most Asked Questions Concerning CEQ's National Environmental Policy Act Regulations A Citizen's Guide to the NEPA: Having Your Voice Heard

  14. Interviewee Travel Regulations Scope

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    23/2012 Interviewee Travel Regulations Scope These regulations apply to the reimbursement of round-trip travel expenses incurred by interviewees. These regulations do not apply to applicants who live within a 50-mile radius of Los Alamos based on the Rand McNally Standard Highway Mileage Guide. Reimbursement With the exception of airfare, interviewees will be reimbursed for travel expenses according to Federal travel regulations. For interviewees, airfare reimbursement is limited to the lesser

  15. ISOs: The new antitrust regulators?

    SciTech Connect (OSTI)

    Raskin, D.B.

    1998-04-01

    Fear of seller market power in emerging electricity markets has led regulators to sanction use of independent system operators as private market police. A more restrained approach is likely to yield better results without the chilling effects of private regulation. This new industry regulatory paradigm has received little critical attention to date. This is unfortunate because ISO antitrust regulation raises serious legal and policy concerns. The California and New England Power Pool (NEPOOL) plans are quite intrusive. They require the ISO to make difficult distinctions between acceptable and unacceptable market behavior. They create considerable risk that desirable competitive behavior will be chilled and that market participants will incur significant explicit and implicit costs to meet regulatory requirements.

  16. Load regulating expansion fixture

    DOE Patents [OSTI]

    Wagner, Lawrence M. (San Jose, CA); Strum, Michael J. (San Jose, CA)

    1998-01-01

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located therebetween. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components.

  17. Load regulating expansion fixture

    DOE Patents [OSTI]

    Wagner, L.M.; Strum, M.J.

    1998-12-15

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils is disclosed. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located therebetween. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components. 1 fig.

  18. Revision of Army regulation (AR) 200-2, environmental effects of Army actions, and the application of total quality mangement (TQM) principles

    SciTech Connect (OSTI)

    Merkel, H,K.; Robitaille, P.

    1995-12-01

    AR 200-2 is the Army`s implementing regulation to the National Environmental Policy Act (NEPA) and DoD`s NEPA Directive DoDD 6050.1. AR 200-2 was last revised in the late 1980s and since then the scope of Army NEPA compliance activities have significantly increased, and NEPA practice and case law are continually changing. The purpose of revising AR 200-2 is to provide Army personel with clear and Concise guidance on how to meet their NEPA compliance requirements. The revision process included reviewing the current AR 200-2 to identify areas and topics needing clarification or modification; conferring with Army NEPA personnel to obtain views on NEPA compliance practices and procedures; conducting a review and analysis of significant, recent developments in NEPA case law; reviewing other federal NEPA implementing regulations to identify useful, transferrable concepts; preparing a {open_quotes}strawman{close_quotes} version of AR 200-2 to use as a starting point in the revision process; coordinating and consolidating input from the AR 200-2 Revisions Steering Committee; and responding to review comments. A draft version of AR 200-2 has been completed and informal Army-wide comments have been addressed. Some of the issues that the AR 200-2 Revisions Steering Committee considered during the revision effort included expanding the list of categorical exclusions, determining the appropriate length for the public comment period for environmental assessments prior to approval of the finding of no significant impact, determining the appropriate level of analysis for Army actions abroad, and determining whether Comprehensive Environmental Response Compensation Liability Act (CERCLA) or Resource Conservation and Recovery Act (RCRA) actions should be addressed under NEPA. Total Quality Management (TQM) principles were applied during the revision process. GroupSystems{trademark} software was used as a vehicle to enhance total group participation from managers to practitioners.

  19. Pressure reducing regulator

    DOE Patents [OSTI]

    Whitehead, John C. (Davis, CA); Dilgard, Lemoyne W. (Willits, CA)

    1995-01-01

    A pressure reducing regulator that controls its downstream or outlet pressure to a fixed fraction of its upstream or inlet pressure. The regulator includes a housing which may be of a titanium alloy, within which is located a seal or gasket at the outlet end which may be made of annealed copper, a rod, and piston, each of which may be made of high density graphite. The regulator is insensitive to temperature by virtue of being without a spring or gas sealed behind a diaphragm, and provides a reference for a system in which it is being used. The rod and piston of the regulator are constructed, for example, to have a 1/20 ratio such that when the downstream pressure is less than 1/20 of the upstream pressure the regulator opens and when the downstream pressure exceeds 1/20 of the upstream pressure the regulator closes.

  20. Pressure reducing regulator

    DOE Patents [OSTI]

    Whitehead, J.C.; Dilgard, L.W.

    1995-10-10

    A pressure reducing regulator that controls its downstream or outlet pressure to a fixed fraction of its upstream or inlet pressure is disclosed. The regulator includes a housing which may be of a titanium alloy, within which is located a seal or gasket at the outlet end which may be made of annealed copper, a rod, and piston, each of which may be made of high density graphite. The regulator is insensitive to temperature by virtue of being without a spring or gas sealed behind a diaphragm, and provides a reference for a system in which it is being used. The rod and piston of the regulator are constructed, for example, to have a 1/20 ratio such that when the downstream pressure is less than 1/20 of the upstream pressure the regulator opens and when the downstream pressure exceeds 1/20 of the upstream pressure the regulator closes. 10 figs.

  1. Policy and Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations Policy and Regulations map-1019833_960_720.jpg

  2. Resources for Utility Regulators

    SciTech Connect (OSTI)

    SEE Action

    2012-06-01

    Provides a summary of State and Local Energy Efficiency Action Network (SEE Action) information resources available to utility regulators, organized by topic.

  3. Montana Rule 36.25.4 Geothermal Rules and Regulations | Open...

    Open Energy Info (EERE)

    Geothermal Rules and RegulationsLegal Abstract Montana regulation governing administration of geothermal resources in the state. Published NA Year Signed or Took Effect...

  4. Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA

    SciTech Connect (OSTI)

    Jiang, Jiahua; Jedinak, Andrej; Sliva, Daniel; Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN; Indiana University Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN

    2011-11-18

    Highlights: Black-Right-Pointing-Pointer Ganodermanontriol (GDNT), a Ganoderma mushroom alcohol, inhibits growth of breast cancer cells. Black-Right-Pointing-Pointer CDC20 is over-expressed in tumors but not in the tumor surrounding tissue in breast cancer patients. Black-Right-Pointing-Pointer GDNT inhibits expression of CDC20 in breast cancer cells. Black-Right-Pointing-Pointer GDNT inhibits cell adhesion, cell migration and cell invasion of breast cancer cells. Black-Right-Pointing-Pointer GDNT inhibits secretion of uPA and down-regulates expression of uPAR in breast cancer cells. -- Abstract: Ganoderma lucidum is a medicinal mushroom that has been recognized by Traditional Chinese Medicine (TCM). Although some of the direct anticancer activities are attributed to the presence of triterpenes-ganoderic and lucidenic acids-the activity of other compounds remains elusive. Here we show that ganodermanontriol (GDNT), a Ganoderma alcohol, specifically suppressed proliferation (anchorage-dependent growth) and colony formation (anchorage-independent growth) of highly invasive human breast cancer cells MDA-MB-231. GDNT suppressed expression of the cell cycle regulatory protein CDC20, which is over-expressed in precancerous and breast cancer cells compared to normal mammary epithelial cells. Moreover, we found that CDC20 is over-expressed in tumors when compared to the tissue surrounding the tumor in specimens from breast cancer patients. GDNT also inhibited invasive behavior (cell adhesion, cell migration, and cell invasion) through the suppression of secretion of urokinase-plasminogen activator (uPA) and inhibited expression of uPA receptor. In conclusion, mushroom GDNT is a natural agent that has potential as a therapy for invasive breast cancers.

  5. WIPP Documents - Federal Regulations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Federal Regulations 40 CFR Part 191 Environmental radiation protection standards for management and disposal of spent nuclear fuel, high-level and transuranic radioactive wastes. 40 CFR Part 194 Criteria for the certification and re-certification of the Waste Isolation Pilot Plant's compliance with the 40 CFR Part 191 disposal regulations.

  6. Cell cycle regulation of human immunodeficiency virus type 1 integration in T cells: antagonistic effects of nuclear envelope breakdown and chromatin condensation

    SciTech Connect (OSTI)

    Mannioui, Abdelkrim . E-mail: karim.mannioui@chu-stlouis.fr; Schiffer, Cecile . E-mail: cecile.schiffer@voila.fr; Felix, Nathalie . E-mail: nathalie.felix@chu-stlouis.fr

    2004-11-10

    We examined the influence of mitosis on the kinetics of human immunodeficiency virus type 1 integration in T cells. Single-round infection of cells arrested in G1b or allowed to synchronously proceed through division showed that mitosis delays virus integration until 18-24 h postinfection, whereas integration reaches maximum levels by 15 h in G1b-arrested cells. Subcellular fractionation of metaphase-arrested cells indicated that, while nuclear envelope disassembly facilitates docking of viral DNA to chromatin, chromosome condensation directly antagonizes and therefore delays integration. As a result of the balance between the two effects, virus integration efficiency is eventually up to threefold greater in dividing cells. At the single-cell level, using a green fluorescent protein-expressing reporter virus, we found that passage through mitosis leads to prominent asymmetric segregation of the viral genome in daughter cells without interfering with provirus expression.

  7. Of Refrigerators & Regulations

    Broader source: Energy.gov [DOE]

    Editor's Note: This entry has been cross-posted from The White House Blog. The President took a moment during his speech to put the debate over regulation in a different perspective.

  8. Title 22 California Code of Regulations | Open Energy Information

    Open Energy Info (EERE)

    Abstract Title 22 California Code of Regulations, current through August 7, 2014. Published NA Year Signed or Took Effect 2014 Legal Citation Title 22 California Code...

  9. SUBPART B - Exception Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    SUBPART B - Exception Regulations SUBPART B - Exception Regulations SUBPART B--EXCEPTIONS Sec. 1003.20 Purpose and scope. (a) This subpart establishes the procedures for applying for an exception, as provided for in § 504 (42 U.S.C. 7194) of the Department of Energy Organization Act (42 U.S.C. 7101 et seq.), from a rule, regulation or DOE action having the effect of a rule as defined by 5 U.S.C. 551(4), based on an assertion of serious hardship, gross inequity or unfair distribution of burdens,

  10. DOE Revises its NEPA Regulations, Including Categorical Exclusions |

    Office of Environmental Management (EM)

    Department of Energy Revises its NEPA Regulations, Including Categorical Exclusions DOE Revises its NEPA Regulations, Including Categorical Exclusions September 30, 2011 - 2:30pm Addthis On September 27, 2011, the Department of Energy (DOE) approved revisions to its National Environmental Policy Act (NEPA) regulations, and on September 28th, submitted the revisions to the Federal Register. The final regulations, which become effective 30 days after publication in the Federal Register, are

  11. Surface mine regulations complicate reclamation

    SciTech Connect (OSTI)

    Seltz-Patrash, A.

    1980-09-01

    The Surface Mining Control and Reclamation Act of 1977 is a landmark environmental law intended to protect U.S. lands from stripmining effects. However, coal mine operators claim that some SMCRA regulations are misguidedcosting time and money, but yielding no substantial environmental benefit. Unlike other environmental acts, SMCRA details specifically the goals of reclamation and the methods that must be implemented to meet these goals. Coal industry representatives believe that this discourages innovation, promotes inefficiency by ignoring regional differences among sites, and results in unnecessary expense to the industry. Reclamation practices and progress among western coal mining companies are evaluated. (1 map, 5 photos)

  12. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit...

  13. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Auxin Regulation Mechanism Discovered Print Wednesday, 29 August 2007 00:00 The plant hormone auxin regulates many plant growth and development processes, including shoot growth,...

  14. Historical impacts of environmental regulation of silver

    SciTech Connect (OSTI)

    Purcell, T.W.; Peters, J.J.

    1999-01-01

    Exposure to silver, and hence its possible environmental effects, has been regulated since the 1960s. Rules were first developed in the United States to protect against potential negative effects to humans due to ingestion of drinking water containing silver. As regulations for other environmental media were developed, silver was generally included because of its designation as a drinking water chemical of concern. Ambient water quality criteria were developed based on the toxic action of ionic silver. In the early 1990s the US Environmental Protection Agency`s Office of Drinking Water downgraded silver from a primary to a secondary maximum contaminant level because the effects of exposure to silver were judged to be cosmetic. Regulations pertaining to solid waste, surface waters, and occupational exposure have not been changed, but may be changed in the near future as the fate and toxic mechanisms of silver become better understood.

  15. Interrelationship of Program Regulations and Financial Assistance Regulations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1980-04-24

    The purpose of this Order is to set forth the interrelationship between all program regulations which will result in assistance awards (Program Regulations) and the Department of Energy Assistance Regulations (DOE-AR, 10 CRF Part 600), including procedures for exceptions, deviations or waivers.

  16. Self-regulating valve

    DOE Patents [OSTI]

    Humphreys, D.A.

    1982-07-20

    A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.

  17. Regulators, Boards, Councils - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulators, Boards, Councils Hanford Advisory Board Hanford Natural Resource Trustee Council Environmental Protection Agency Washington State Department of Ecology Defense...

  18. Temperature controlled high voltage regulator

    DOE Patents [OSTI]

    Chiaro, Jr., Peter J. (Clinton, TN); Schulze, Gerald K. (Knoxville, TN)

    2004-04-20

    A temperature controlled high voltage regulator for automatically adjusting the high voltage applied to a radiation detector is described. The regulator is a solid state device that is independent of the attached radiation detector, enabling the regulator to be used by various models of radiation detectors, such as gas flow proportional radiation detectors.

  19. Exceptions to DOE Rules and Regulations | Department of Energy

    Office of Environmental Management (EM)

    Exceptions to DOE Rules and Regulations Exceptions to DOE Rules and Regulations The Department of Energy (DOE) issues test procedures and regulations covering a number of products, but does provide for exceptions to these rules under certain circumstances. Any person, as defined by 10 CFR 1003.2, can apply to the DOE for an exception from a rule, regulation, or DOE action having the effect of a rule, as provided for in section 504 of 42 U.S.C. 7194 and codified in 10 CFR 1003 subpart B. The DOE

  20. Vermont Hazardous Waste Management Regulations | Open Energy...

    Open Energy Info (EERE)

    Hazardous Waste Management Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Vermont Hazardous Waste Management...

  1. OAR 632-020 - Geothermal Regulations | Open Energy Information

    Open Energy Info (EERE)

    - Geothermal RegulationsLegal Published NA Year Signed or Took Effect 1972 Legal Citation OAR 632-020 (1972) DOI Not Provided Check for DOI availability: http:crossref.org...

  2. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Unique Auxin Regulation Mechanism Discovered Print Wednesday, 29 August 2007 00:00 The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction

  3. Effects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Effects of particles with large gyroradii on resistive magnetohydrodynamic stability V. A. Svidzinski and S. C. Prager University of Wisconsin-Madison, Madison, Wisconsin 53706 ͑Received 19 September 2003; accepted 25 November 2003͒ Fast ions in tokamaks are known to have a significant influence on global plasma instabilities. In normal mode analyses for tokamaks, the perturbed electric and magnetic fields have been evaluated at the position of the particle's guiding center. The effect of

  4. certification, compliance and enforcement regulations for Commercial...

    Office of Environmental Management (EM)

    regulations for Commercial Refrigeration Equipment (CRE) certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) The current ...

  5. Litigation, Regulation and Enforcement | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Litigation, Regulation and Enforcement Litigation, Regulation and Enforcement Litigation, Regulation and Enforcement Offices of the Deputy General Counsel for Litigation, Regulation and Enforcement Office of the Assistant General Counsel for Litigation (GC-31) Office of the Assistant General Counsel for Enforcement (GC-32) Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency (GC-33) Litigation, Regulation and Enforcement Litigation Enforcement Legislation,

  6. RNA-guided transcriptional regulation

    DOE Patents [OSTI]

    Church, George M.; Mali, Prashant G.; Esvelt, Kevin M.

    2016-02-23

    Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.

  7. Upward-facing Lithium Flash Evaporator for NSTX-U

    Office of Scientific and Technical Information (OSTI)

    ... The minimal time interval between the evaporation and the start of the discharge will avoid the passivation of the lithium by residual gases and enable the study of the ...

  8. Federal Acquisition Regulation

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    3 & 2005-74 Summary of Rules FAC 2005-73 Item Subject FAR Case I Positive Law Codification of Title 41 2011-018 II Technical Amendments Item I--Positive Law Codification of Title 41 (FAR Case 2011-018) Title 41 of the United States Code, "Public Contracts" was enacted into positive law on January 4, 2011 (Pub.L 111-350). This codification reorganized and renumbered the statutes, but did not change their meaning or legal effect. This final rule amended the Federal Acquisition

  9. Side-gate modulation effects on high-quality BN-Graphene-BN nanoribbon capacitors

    SciTech Connect (OSTI)

    Wang, Yang; Chen, Xiaolong; Ye, Weiguang; Wu, Zefei; Han, Yu; Han, Tianyi; He, Yuheng; Cai, Yuan; Wang, Ning

    2014-12-15

    High-quality BN-Graphene-BN nanoribbon capacitors with double side-gates of graphene have been experimentally realized. The double side-gates can effectively modulate the electronic properties of graphene nanoribbon capacitors. By applying anti-symmetric side-gate voltages, we observed significant upward shifting and flattening of the V-shaped capacitance curve near the charge neutrality point. Symmetric side-gate voltages, however, only resulted in tilted upward shifting along the opposite direction of applied gate voltages. These modulation effects followed the behavior of graphene nanoribbons predicted theoretically for metallic side-gate modulation. The negative quantum capacitance phenomenon predicted by numerical simulations for graphene nanoribbons modulated by graphene side-gates was not observed, possibly due to the weakened interactions between the graphene nanoribbon and side-gate electrodes caused by the Ga{sup +} beam etching process.

  10. Alternative Fuels Data Center: Conversion Regulations

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Conversion Regulations to someone by E-mail Share Alternative Fuels Data Center: Conversion Regulations on Facebook Tweet about Alternative Fuels Data Center: Conversion Regulations on Twitter Bookmark Alternative Fuels Data Center: Conversion Regulations on Google Bookmark Alternative Fuels Data Center: Conversion Regulations on Delicious Rank Alternative Fuels Data Center: Conversion Regulations on Digg Find More places to share Alternative Fuels Data Center: Conversion Regulations on

  11. Environmental Regulations | Open Energy Information

    Open Energy Info (EERE)

    Regulations Jump to: navigation, search To do: add table This article is a stub. You can help OpenEI by expanding it. Retrieved from "http:en.openei.orgwindex.php?titleEnviron...

  12. APPARATUS FOR REGULATING HIGH VOLTAGE

    DOE Patents [OSTI]

    Morrison, K.G.

    1951-03-20

    This patent describes a high-voltage regulator of the r-f type wherein the modulation of the r-f voltage is accomplished at a high level, resulting in good stabilization over a large range of load conditions.

  13. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction machinery system) was identified as a receptor for auxin. Now, an

  14. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction machinery system) was identified as a receptor for auxin. Now, an

  15. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction machinery system) was identified as a receptor for auxin. Now, an

  16. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction machinery system) was identified as a receptor for auxin. Now, an

  17. Federal Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Regulations Federal Regulations NOTE: Adobe Acrobat Reader may be necessary to view PDF documents listed below. Accessibility Section 508 of the Rehabilitation Act - Electronic and Information Technology Accessibility Standards Section 504 of the Rehabilitation Act - Nondiscrimination Under Federal Grants and Programs Federal Records Act Freedom of Information Act (as amended) Freedom of Information Act Updates Privacy Act of 1974 (as amended) Privacy Act Overview Cyber Security Atomic

  18. Federal Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Regulations Federal Regulations keyboard-621831_960_720.jpg Cybersecurity Atomic Energy Act of 1954 (pdf) Computer Fraud and Abuse Act of 1986 Electronic Communications Privacy Act of 1986 Federal Information Security Management Act of 2002 (Title III of E-Gov) Homeland Security Act of 2002 (includes Cyber Security Act of 2002 and Critical Infrastructure Act of 2002) Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act Cyber

  19. Environmental regulation of coal mining, SMCRA`s second decade

    SciTech Connect (OSTI)

    McElfish, J.M.; Beier, A.E.

    1990-12-31

    This controversial book examines environmental regulation of coal mining in the United States over the 1979-1989 period. The Surface Mining Control and Reclamation Act of 1977 (SMCRA) established federal regulation of the environmental effects of coal mining. The permanent regulatory program implementing SMCRA was initiated in 1979. This book looks at the first ten years of SMCRA, seeking to draw lessons from experience that will improve regulation, so that the objectives of the law may be achieved in SMCRA`s second decade.

  20. 40 CFR 1500-1508: CEQ Regulations for Implementing the Procedural

    Energy Savers [EERE]

    Provisions of NEPA | Department of Energy 40 CFR 1500-1508: CEQ Regulations for Implementing the Procedural Provisions of NEPA 40 CFR 1500-1508: CEQ Regulations for Implementing the Procedural Provisions of NEPA PDF icon CEQ Regulations for Implementing the Procedural Provisions of NEPA (40 CFR 1500-1508) More Documents & Publications Effective Public Participation Forty Most Asked Questions Concerning CEQ's National Environmental Policy Act Regulations (CEQ, 1986) A Citizen's Guide to

  1. Post regulation circuit with energy storage

    DOE Patents [OSTI]

    Ball, Don G.; Birx, Daniel L.; Cook, Edward G.

    1992-01-01

    A charge regulation circuit provides regulation of an unregulated voltage supply and provides energy storage. The charge regulation circuit according to the present invention provides energy storage without unnecessary dissipation of energy through a resistor as in prior art approaches.

  2. Output-Based Regulations: A Handbook for Air Regulators (U.S...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Output-Based Regulations: A Handbook for Air Regulators (U.S. EPA), August 2004 Output-Based Regulations: A Handbook for Air Regulators (U.S. EPA), August 2004 The U.S....

  3. Environmental Regulation Impacts on Eastern Interconnection Performance

    SciTech Connect (OSTI)

    Markham, Penn N; Liu, Yilu; Young II, Marcus Aaron

    2013-07-01

    In the United States, recent environmental regulations will likely result in the removal of nearly 30 GW of oil and coal-fired generation from the power grid, mostly in the Eastern Interconnection (EI). The effects of this transition on voltage stability and transmission line flows have previously not been studied from a system-wide perspective. This report discusses the results of power flow studies designed to simulate the evolution of the EI over the next few years as traditional generation sources are replaced with environmentally friendlier ones such as natural gas and wind.

  4. International Electricity Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation International Electricity Regulation U.S. trade in electric energy with Canada and Mexico is rising, bringing economic and reliability benefits to the United States and ...

  5. Fish Habitat Regulations | Open Energy Information

    Open Energy Info (EERE)

    Fish Habitat Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Fish Habitat Regulations Author Alaska Department of Fish & Game Published...

  6. Alaska ADEC Wetlands Regulation | Open Energy Information

    Open Energy Info (EERE)

    Wetlands Regulation Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Alaska ADEC Wetlands Regulation Author Alaska Division of Water Published Alaska...

  7. Body temperature regulation during euthermia and hyperthermia

    SciTech Connect (OSTI)

    Shimada, S.G.; Stitt, J.T.

    1981-10-01

    In this paper we have presented a few fundamental principles which are essential for an understanding of how microwaves might affect body temperature regulation. Application of the heat balance equation requires an accounting of all heat losses and heat gains. Thus, experimental measurements of these two processes are usually required to explain any thermoregulatory response. Knowledge of the individual elements of the thermoregulatory system and their integrative operation is imperative. Without such information one cannot hope to analyze or predict the consequences of microwave irradiation, or to separate simple heating effects from possible nonthermal effects. Finally, we have tried to emphasize that hyperthermia can be produced in different ways. Thus, there may be several forms of microwave hyperthermia, differing in their causality. Deposition of microwave energy in deep tissues might produce a response similar to exercise hyperthermia.

  8. Chapter 2 of the Wyoming Public Service Commission Regulations...

    Open Energy Info (EERE)

    2 of the Wyoming Public Service Commission Regulations: General Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation:...

  9. Natural Gas Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Natural Gas Regulation Natural Gas Regulation Natural Gas Regulation The Natural Gas Act of 1938, as amended, requires any person who wishes to import and/or export natural gas, (including liquefied natural gas, compressed natural gas, compressed gas liquids, etc.) from or to a foreign country must first obtain an authorization from the Department of Energy. The authorizations are granted by the Office of Regulation and International Engagement, Division of Natural Gas Regulation. DOE grants two

  10. Frequency regulator for synchronous generators

    DOE Patents [OSTI]

    Karlicek, R.F.

    1982-08-10

    The present invention is directed to a novel frequency regulator which controls a generator output frequency for variations in both the input power to the generator and the power supplied to an uncontrolled external load. The present invention further includes over current and current balance protection devices which are relatively inexpensive to manufacture, which may be encapsulated to provide protection from the operating environment and which respond more quickly than previously known electromechanical devices. 11 figs.

  11. Frequency regulator for synchronous generators

    DOE Patents [OSTI]

    Karlicek, Robert F. (1920 Camino Centroloma, Fullerton, CA 92633)

    1982-01-01

    The present invention is directed to a novel frequency regulator which controls a generator output frequency for variations in both the input power to the generator and the power supplied to an uncontrolled external load. The present invention further includes over current and current balance protection devices which are relatively inexpensive to manufacture, which may be encapsulated to provide protection from the operating environment and which respond more quickly than previously known electromechanical devices.

  12. GP-8 LAWS AND REGULATIONS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    40-DOP (5-2011) Supersedes (7-2010) issue DECLARATION of OCCUPATIONAL MEDICINE PROVIDER GENERAL INFORMATION PURPOSE All Contractors and their lower-tier subcontractors must comply with the Department of Energy's Worker Safety and Health Program regulation, 10 CFR 851, "Worker Safety and Health Program (WSHP). The WSHP enforces worker safety and health requirements including, but not limited to, standards of the Occupational Safety and Health Administration (OSHA), American National

  13. Improving Regulation and Regulatory Review

    Office of Environmental Management (EM)

    Alton Strategic Environmental Group New Port Richey, FL charles.alton@earthlink.net April 4, 2011 Daniel Cohen, Assistant General Counsel Legislation, Regulation, and Energy Efficiency Office of the General Counsel U.S. Department of Energy 1000 Independence Avenue, SW Washington, DC 20585 Dear Mr. Cohen: I have reviewed the Request For Information regarding Reducing Regulatory Reform issued February 3, 2011 (Federal Register /Vol. 76, No. 23 /Thursday, February 3, 2011 /Notices). In the

  14. NRC - regulator of nuclear safety

    SciTech Connect (OSTI)

    1997-05-01

    The U.S. Nuclear Regulatory Commission (NRC) was formed in 1975 to regulate the various commercial and institutional uses of nuclear energy, including nuclear power plants. The agency succeeded the Atomic Energy Commission, which previously had responsibility for both developing and regulating nuclear activities. Federal research and development work for all energy sources, as well as nuclear weapons production, is now conducted by the U.S. Department of Energy. Under its responsibility to protect public health and safety, the NRC has three principal regulatory functions: (1) establish standards and regulations, (2) issue licenses for nuclear facilities and users of nuclear materials, and (3) inspect facilities and users of nuclear materials to ensure compliance with the requirements. These regulatory functions relate to both nuclear power plants and to other uses of nuclear materials - like nuclear medicine programs at hospitals, academic activities at educational institutions, research work, and such industrial applications as gauges and testing equipment. The NRC places a high priority on keeping the public informed of its work. The agency recognizes the interest of citizens in what it does through such activities as maintaining public document rooms across the country and holding public hearings, public meetings in local areas, and discussions with individuals and organizations.

  15. Output-Based Regulations: A Handbook for Air Regulators (U.S. EPA), August

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2004 | Department of Energy Output-Based Regulations: A Handbook for Air Regulators (U.S. EPA), August 2004 Output-Based Regulations: A Handbook for Air Regulators (U.S. EPA), August 2004 The U.S. Environmental Protection Agency (EPA) developed this handbook to assist state, local, and tribal regulators in developing output-based regulations. The handbook provides practical information to help regulators decide if they want to use output-based regulations and explains how to develop an

  16. Colorado Code of Regulations 4 CCR 723-3, Rules Regulating Electric...

    Open Energy Info (EERE)

    Colorado Code of Regulations 4 CCR 723-3, Rules Regulating Electric Utilities Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  17. Code of Colorado Regulations 4 CCR 723-3, Rules Regulating Electric...

    Open Energy Info (EERE)

    Code of Colorado Regulations 4 CCR 723-3, Rules Regulating Electric Utilities Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  18. Clean Water Act and Regulations (EPA)

    Broader source: Energy.gov [DOE]

    The Clean Water Act (CWA; 33 U.S.C. §1251 et seq.) establishes the basic structure for regulating discharges of pollutants into the waters of the United States and regulating quality standards for surface waters.

  19. certification, compliance and enforcement regulations for Commercial

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Refrigeration Equipment (CRE) | Department of Energy certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) The current certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) "simply makes no sense". The regulations define the basic model as any product that has a different energy use or efficiency

  20. Investment and regulation: the Dutch experience

    SciTech Connect (OSTI)

    Haffner, Robert; Helmer, Dorine; van Til, Harry

    2010-06-15

    Theoretical studies on the relationship between incentive regulation and investment in network industries generally point out that incentive regulation has a negative impact on investment. However, empirical evidence in this area is scarce. An analysis suggests that in the Dutch electricity and gas networks since 2001, incentive regulation has ensured a more rational and professional approach towards investments, with investment levels coming down somewhat at the start of the regulation but picking up later on. (author)

  1. Regulations for beneficial use changing nationwide

    SciTech Connect (OSTI)

    Goss, D.

    2008-07-01

    Regulations on the use of coal combustion products (CCPs) that are being considered by various US states are reviewed.

  2. Environmental Laws and Regulations | Department of Energy

    Office of Environmental Management (EM)

    Environmental Laws and Regulations Environmental Laws and Regulations This document defines and explains the environmental laws and regulations that direct our program. Specifically the document discusses: The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) The Resource Conservation and Recovery Act of 1976 (RCRA) The National Environmental Policy Act (NEPA) Federal Facility Agreement (FFA) Superfund Records of Decisions Removal Actions Administrative Record Files

  3. The impact of environmental regulation on productivity in the US fossil-fueled power plants

    SciTech Connect (OSTI)

    Whang, J.

    1993-12-31

    The purpose of this dissertation is to examine the impact of environmental regulation on productivity in the U.S. fossil fueled electric generating industry. With the oil shocks, environmental regulation has been considered as one of the main culprits for the apparent productivity slowdown during the 1970`s. Even though new pieces of legislation are continuously enacted to regulate hazardous pollutants emitted, it is difficult to find thorough and meaningful analyses on the effects of regulation. Without exact measurement of regulation effects, it is not easy to design socially efficient environmental policies to reconcile several conflicting goals. Using plant-level production and environmental data for the last two decades, the effects of differentiated environmental regulation are carefully examined. Since unbalanced panel data set is used, fixed-effects and random-effects models are also examined. The estimated impact of environmental regulation explains 6 to 10 percent of the variation of total factor productivity growth rates. This appears to be a relatively mild effect compared with several previous studies.

  4. Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR alpha

    SciTech Connect (OSTI)

    Genoux, Annelise; Dehondt, Helene; Helleboid-Chapman, Audrey; Duhem, Christian; Hum, Dean W.; Martin, Genevieve; Pennacchio, Len; Staels, Bart; Fruchart-Najib, Jamila; Fruchart, Jean-Charles

    2004-10-01

    Apolipoprotein A5 has recently been identified as a crucial determinant of plasma triglyceride levels. Our results showed that RORa up-regulates human APOA5 but has no effect on mouse apoa5 promoter. These data suggest an additional important physiological role for RORa in the regulation of genes involved in plasma triglyceride homeostasis in human and probably in the development of atherosclerosis

  5. Staff Listing - Office of Regulation and International Engagement, Division

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Natural Gas Regulation, Division of International Engagement | Department of Energy Staff Listing - Office of Regulation and International Engagement, Division of Natural Gas Regulation, Division of International Engagement Staff Listing - Office of Regulation and International Engagement, Division of Natural Gas Regulation, Division of International Engagement Office of Regulation and International Engagement Mailing Address: Office of Regulation and International Engagement Office of

  6. Harmonization - Two Years' of Transportation Regulation Lessons Learned

    SciTech Connect (OSTI)

    Colborn, K.

    2007-07-01

    The U.S. Department of Transportation issued modifications to the Hazardous Materials Regulations in October, 2004 as part of an ongoing effort to 'harmonize' U.S. regulations with those of the International Atomic Energy Agency. The harmonization effort had several predictable effects on low level radioactive materials shipment that were anticipated even prior to their implementation. However, after two years' experience with the new regulations, transporters have identified several effects on transportation which were not entirely apparent when the regulations were first implemented. This paper presents several case studies in the transportation of low level radioactive materials since the harmonization rules took effect. In each case, an analysis of the challenge posed by the regulatory revision is provided. In some cases, more than one strategy for compliance was considered, and the advantages and disadvantages of each are discussed. In several cases, regulatory interpretations were sought and obtained, and these are presented to clarify the legitimacy of the compliance approach. The presentation of interpretations will be accompanied by reports of clarifying discussions with the U.S. DOT about the interpretation and scope of the regulatory change. Specific transportation issues raised by the revised hazardous materials regulations are reviewed, including: The new definition of radioactive material in accordance with isotope-specific concentration and total activity limits. The new hazardous materials regulations (HMR) created a new definition for radioactive material. A case study is presented for soils contaminated with low levels of Th-230. These soils had been being shipped for years as exempt material under the old 2,000 pCi/g concentration limit. Under the new HMR, these same soils were radioactive material. Further, in rail-car quantities their activity exceeded an A2 value, so shipment of the material in gondolas appeared to require an IP-2 package. Interpretations, discussions, and an exemption were obtained to secure the continued shipment of this material. A provision to allow 'natural' radioactive materials to be exempt from the requirements of the HMR at up to 10x the listed isotopic concentrations. The revised HMR exempts certain natural materials and ores from regulation as radioactive material at concentrations up to 10x that allowed if the materials are not natural. The term 'natural' is not well defined, and initial attempts to qualify for this exemption were thwarted by concerns over what degree of material processing, if any, materials could experience and still be considered 'natural'. The presentation includes an example from a project involving post-processed tungsten ore, and includes interpretations from the US DOT as well as clarifying language from current and drafted IAEA regulation and guidance. New packaging descriptions allowing the use of cargo containers as IP-2 and IP-3 packages in some applications. The revised HMR provides an alternate certification procedure under which standard cargo containers can be used as IP-2 and IP-3 containers. There has been some confusion about how this high level of certification can apply to standard cargo containers when other sections of the regulations make this certification available only to considerably more stout containers after rigorous testing. The discussion includes interpretive guidance from the US DOT, and from the UK Department of Transport clarifying the same provision in IAEA regulations. A new definition of contamination with apparently broad impact on the shipment of empty containers and conveyances. The revised HMR presented a definition of contamination not referenced by any other part of the HMR. The preamble to the revised HMR provides confusing guidance on the application of the definition to shipment of empty containers, and subsequent interpretive guidance letters appear to conflict with the preamble as well as with each other. The definition also has the effect of regulating materials for transport as radioactive even when US

  7. Title 27 California Code of Regulations: Environmental Protection...

    Open Energy Info (EERE)

    7 California Code of Regulations: Environmental Protection Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Title 27...

  8. Rules and Regulations of the Wyoming Industrial Siting Council...

    Open Energy Info (EERE)

    Document- RegulationRegulation: Rules and Regulations of the Wyoming Industrial Siting Council - Chapter 1Legal Abstract Industrial development information and siting rules and...

  9. Advisory Council on Historic Preservation - Section 106 Regulations...

    Open Energy Info (EERE)

    OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Advisory Council on Historic Preservation - Section 106 RegulationsLegal Abstract Section 106 requires...

  10. Rules and Regulations of the Wyoming Industrial Siting Council...

    Open Energy Info (EERE)

    Document- RegulationRegulation: Rules and Regulations of the Wyoming Industrial Siting Council - Chapter 2Legal Abstract Rules of practice and proceedures of the Industrial Siting...

  11. Rules and Regulations of the Industrial Siting Council, Chapter...

    Open Energy Info (EERE)

    Industrial Siting Council, Chapter 1 Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Rules and Regulations of the...

  12. 18 CFR 380 Regulations Implementing the National Environmental...

    Open Energy Info (EERE)

    380 Regulations Implementing the National Environmental Policy Act Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 18 CFR...

  13. Chapter 9 of the Wyoming Public Service Commission Regulations...

    Open Energy Info (EERE)

    9 of the Wyoming Public Service Commission Regulations: General Forms Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation:...

  14. 2011 Air Quality Regulations Report | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Air Quality Regulations Report 2011 Air Quality Regulations Report PDF icon 2011 Air Quality Regulations Report120111.pdf More Documents & Publications 2011:...

  15. 2011: Air Quality Regulations Report | Department of Energy

    Office of Environmental Management (EM)

    : Air Quality Regulations Report 2011: Air Quality Regulations Report PDF icon 2011 Air Quality Regulations ReportA120911.pdf More Documents & Publications 2011...

  16. WAC - 173-303 Dangerous Waste Regulations | Open Energy Information

    Open Energy Info (EERE)

    03 Dangerous Waste Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC - 173-303 Dangerous Waste...

  17. Small Self-Regulating Fission Reactor System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    359 This document is approved for public release; further dissemination unlimited Small Self-Regulating Fission Reactor System ANTICIPATED IMPACT PATH FORWARD DESCRIPTION BACKGROUND & MOTIVATION INNOVATION A power system for special government applications Point of Contact: Patrick McClure, NEN-5, pmcclure@lanl.gov (505)667-9534 Small Self-Regulating Fission Reactor System A small self- regulating fission reactor made with U 235 . LANL and NASA with the support of NSTec performed a proof of

  18. Categorical Exclusion Determinations: Natural Gas Regulation | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Natural Gas Regulation Categorical Exclusion Determinations: Natural Gas Regulation Categorical Exclusion Determinations issued by Natural Gas Regulation. DOCUMENTS AVAILABLE FOR DOWNLOAD October 14, 2011 CX-006821: Categorical Exclusion Determination ConocoPhillips Company CX(s) Applied: B5.7 Date: 10/14/2011 Location(s): Quintana Island, Texas Office(s): Fossil Energy, NNSA-Headquarters July 19, 2011 CX-006219: Categorical Exclusion Determination Freeport Liquefied Natural Gas

  19. EPA Regulation Compliance | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EPA Regulation Compliance EPA Regulation Compliance OE offers technical assistance on implementing the new and pending EPA air rules affecting the electric utility industry. Examples of typical assistance include technical information on cost and performance of the various power plant pollution retrofit control technologies; technical information on generation, demand-side or transmission alternatives for any replacement power needed for retiring generating units; and assistance to regulators

  20. ACHP - Section 106 Regulations Flowchart Explanatory Material...

    Open Energy Info (EERE)

    Explanatory Material Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: ACHP - Section 106 Regulations Flowchart Explanatory Material Abstract This...

  1. Collegiate Wind Competition Rules and Regulations | Department...

    Office of Environmental Management (EM)

    More Documents & Publications Collegiate Wind Competition 2014 Rules and Regulations Team roster: Andrew Dallas, Aerospace Engineering; Mario Mondal, Aerospace Engineering; Atif ...

  2. Texas Railroad Commission - Pollution Discharge Regulations ...

    Open Energy Info (EERE)

    Not Provided DOI Not Provided Check for DOI availability: http:crossref.org Online Internet link for Texas Railroad Commission - Pollution Discharge Regulations Citation...

  3. Alaska Special Area Regulations | Open Energy Information

    Open Energy Info (EERE)

    to library Web Site: Alaska Special Area Regulations Author Alaska Department of Fish & Game Published Publisher Not Provided, 2014 DOI Not Provided Check for DOI...

  4. EPA Regulations Overview Website | Open Energy Information

    Open Energy Info (EERE)

    Overview Website Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: EPA Regulations Overview Website Abstract This website contains information about...

  5. Exporting licensing regulations affecting US geothermal firms

    SciTech Connect (OSTI)

    Not Available

    1988-08-01

    This document presents a brief introduction and overview of the Department of Commerce's Export Administration Regulations which might affect potential US geothermal goods exporters. It is intended to make US geothermal firms officials aware of the existence of such regulations and to provide them with references, contacts and phone numbers where they can obtain specific and detailed information and assistance. It must be stressed however, that the ultimate responsibility for complying with the above mentioned regulations lies with the exporter who must consult the complete version of the regulations.

  6. Regulations, Guidelines and Codes and Standards

    Broader source: Energy.gov [DOE]

    Many regulations, guidelines, and codes and standards have already been established through years of hydrogen use in industrial and aerospace applications. In addition, systems and organizations...

  7. WYDOT - Utility Accommodation Regulation Manual | Open Energy...

    Open Energy Info (EERE)

    Regulation ManualPermittingRegulatory GuidanceGuideHandbook Abstract This manual sets forth the processes and procedures for utility accommodation on WYDOT rights-of-way. Author...

  8. Council on Environmental Quality - Regulations for Implementing...

    Open Energy Info (EERE)

    Implementing the Procedural Provisions of the NEPALegal Abstract These regulations set forth the processes and procedures of the National Environmental Policy Act. Published NA...

  9. Regulation Services with Demand Response - Energy Innovation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulation Services with Demand Response Pacific Northwest National Laboratory Contact PNNL About This Technology Using grid frequency information, researchers have created ...

  10. UAC R307 - Air Quality Regulations | Open Energy Information

    Open Energy Info (EERE)

    07 - Air Quality Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: UAC R307 - Air Quality RegulationsLegal...

  11. 5 CCR 1002-62 Colorado Regulations for Effluent Limitations ...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 5 CCR 1002-62 Colorado Regulations for Effluent LimitationsLegal Abstract Regulations...

  12. Quantifying and Generalizing Hydrologic Responses to Dam Regulation using a Statistical Modeling Approach

    SciTech Connect (OSTI)

    McManamay, Ryan A

    2014-01-01

    Despite the ubiquitous existence of dams within riverscapes, much of our knowledge about dams and their environmental effects remains context-specific. Hydrology, more than any other environmental variable, has been studied in great detail with regard to dam regulation. While much progress has been made in generalizing the hydrologic effects of regulation by large dams, many aspects of hydrology show site-specific fidelity to dam operations, small dams (including diversions), and regional hydrologic regimes. A statistical modeling framework is presented to quantify and generalize hydrologic responses to varying degrees of dam regulation. Specifically, the objectives were to 1) compare the effects of local versus cumulative dam regulation, 2) determine the importance of different regional hydrologic regimes in influencing hydrologic responses to dams, and 3) evaluate how different regulation contexts lead to error in predicting hydrologic responses to dams. Overall, model performance was poor in quantifying the magnitude of hydrologic responses, but performance was sufficient in classifying hydrologic responses as negative or positive. Responses of some hydrologic indices to dam regulation were highly dependent upon hydrologic class membership and the purpose of the dam. The opposing coefficients between local and cumulative-dam predictors suggested that hydrologic responses to cumulative dam regulation are complex, and predicting the hydrology downstream of individual dams, as opposed to multiple dams, may be more easy accomplished using statistical approaches. Results also suggested that particular contexts, including multipurpose dams, high cumulative regulation by multiple dams, diversions, close proximity to dams, and certain hydrologic classes are all sources of increased error when predicting hydrologic responses to dams. Statistical models, such as the ones presented herein, show promise in their ability to model the effects of dam regulation effects at large spatial scales as to generalize the directionality of hydrologic responses.

  13. Magnet power supply regulation comments: 240 kW and 500 kW magnet power supplies

    SciTech Connect (OSTI)

    Visser, A.T.

    1993-03-01

    This note is written for users who need better than about 100 ppm regulated magnet fields in electromagnets. A magnet excitation current regulation of 100 ppm is generally specified to obtain this field regulation, but there are many other variables, in addition to magnet excitation that can change the magnet field. The effects of these other variables are often overlooked or underestimated. If things do not work out, the power supply often gets blamed. A field regulation of 100 ppm requires that the power supply regulates substantially better than 100 ppm and that the effects of other variables are limited. Before we can talk about regulation we must define what regulation is. Power supplies can be regulated for current or voltage. We will only talk about current regulation, since that is the regulation mode used to establish precisely regulated magnetic fields in electromagnets. It is assumed that the same current value will always produce the same corresponding magnetic field value. Later on we will discuss that this assumption is not correct.

  14. Rainwater harvesting state regulations and technical resources

    SciTech Connect (OSTI)

    Loper, Susan A.

    2015-06-01

    Pacific Northwest National Laboratory (PNNL) conducted in-depth research of state-level rainwater harvesting regulations for the Federal Energy Management Program (FEMP) to help federal agencies strategically identify locations conducive to rainwater harvesting projects. Currently, rainwater harvesting is not regulated by the federal government but rather it is up to individual states to regulate the collection and use of rainwater. There is no centralized information on state-level regulations on rainwater harvesting maintained by a federal agency or outside organization. To fill this information gap, PNNL performed detailed internet searches for each state, which included state agencies, universities, Cooperative Extension Offices, city governments, and related organizations. The state-by-state information on rainwater harvesting regulations was compiled and assembled into an interactive map that is color coded by state regulations. The map provides a visual representation of the general types of rainwater harvesting policies across the country as well as general information on the state programs if applicable. The map allows the user to quickly discern where rainwater harvesting is supported and regulated by the state. This map will be available on the FEMP website by September 2015.

  15. Regulation of geothermal energy development in Colorado

    SciTech Connect (OSTI)

    Coe, B.A.; Forman, N.A.

    1980-01-01

    The regulatory system is presented in a format to help guide geothermal energy development. State, local, and federal agencies, legislation, and regulations are presented. Information sources are listed. (MHR)

  16. North America: Regulation of International Electricity Trade...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Between the United States and Canada Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States EA-48-M El Paso Electric Company...

  17. Statutes, Regulations, and Directives for Classification Program |

    Energy Savers [EERE]

    Department of Energy Statutes, Regulations, and Directives for Classification Program Statutes, Regulations, and Directives for Classification Program Classification Atomic Energy Act of 1954 - Establishes Government-wide policies for classifying, safeguarding, and declassifying Restricted Data information. 10 CFR Part 1045, Nuclear Classification and Declassification - Establishes the Government-wide policies and procedures for implementing sections 141 and 142 of the Atomic Energy Act of

  18. International Electricity Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation International Electricity Regulation U.S. trade in electric energy with Canada and Mexico is rising, bringing economic and reliability benefits to the United States and its trading partners. Within the Office of Electricity Delivery & Energy Reliability, the Permitting, Siting and Analysis Division is responsible for authorizing exports of electric energy and issuing Presidential permits for the construction, operation, maintenance and connection of electric transmission

  19. Searchable Electronic Department of Energy Acquisition Regulation |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Searchable Electronic Department of Energy Acquisition Regulation Searchable Electronic Department of Energy Acquisition Regulation Updated July 2, 2013. The EDEAR is current through the Final Rule published May 3, 2013 at 78 FR 25817 If you have any questions concerning this page, please contact Barbara Binney in the Contract and Financial Assistance Policy Division, Office of Acquisition and Project Management. PDF icon EDEAR July 2 2013 final.pdf More Documents &

  20. REGULATIONS ON PHOTOVOLTAIC MODULE DISPOSAL AND RECYCLING.

    SciTech Connect (OSTI)

    FTHENAKIS,V.

    2001-01-29

    Environmental regulations can have a significant impact on product use, disposal, and recycling. This report summarizes the basic aspects of current federal, state and international regulations which apply to end-of-life photovoltaic (PV) modules and PV manufacturing scrap destined for disposal or recycling. It also discusses proposed regulations for electronics that may set the ground of what is to be expected in this area in the near future. In the US, several states have started programs to support the recycling of electronic equipment, and materials destined for recycling often are excepted from solid waste regulations during the collection, transfer, storage and processing stages. California regulations are described separately because they are different from those of most other states. International agreements on the movement of waste between different countries may pose barriers to cross-border shipments. Currently waste moves freely among country members of the Organization of Economic Cooperation and Development (OECD), and between the US and the four countries with which the US has bilateral agreements. However, it is expected, that the US will adopt the rules of the Basel Convention (an agreement which currently applies to 128 countries but not the US) and that the Convection's waste classification system will influence the current OECD waste-handling system. Some countries adopting the Basel Convention consider end-of-life electronics to be hazardous waste, whereas the OECD countries consider them to be non-hazardous. Also, waste management regulations potentially affecting electronics in Germany and Japan are mentioned in this report.

  1. EO 13211: Regulations That Significantly Affect Energy Supply, Distribution, or Use

    Office of Environmental Management (EM)

    5 Federal Register / Vol. 66, No. 99 / Tuesday, May 22, 2001 / Presidential Documents Executive Order 13211 of May 18, 2001 Actions Concerning Regulations That Significantly Affect En- ergy Supply, Distribution, or Use By the authority vested in me as President by the Constitution and the laws of the United States of America, and in order to appropriately weigh and consider the effects of the Federal Government's regulations on the supply, distribution, and use of energy, it is hereby ordered as

  2. Smart Grid Newsletter ? The Regulators Role in Grid Modernization...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Title: "The Regulator's Role in Grid Modernization" Sponsor: The Modern Grid Strategy is a DOE-funded project conducted by the National Energy Technology Laboratory Leadership from...

  3. Rules and Regulations of the Board of Land Commissioners, Chapter...

    Open Energy Info (EERE)

    Board of Land Commissioners, Chapter 3 - Easements Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Rules and Regulations of...

  4. WAC - 173-360 Underground Storage Tank Regulations | Open Energy...

    Open Energy Info (EERE)

    60 Underground Storage Tank Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC - 173-360 Underground Storage...

  5. WAC 173-400 - General Regulations for Air Pollution Sources ...

    Open Energy Info (EERE)

    400 - General Regulations for Air Pollution Sources Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC 173-400 - General...

  6. WAC - 173-400 General Regulations for Air Pollution Sources ...

    Open Energy Info (EERE)

    400 General Regulations for Air Pollution Sources Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC - 173-400 General...

  7. Form:Federal Oil and Gas Regulation | Open Energy Information

    Open Energy Info (EERE)

    Federal Oil and Gas Regulation Jump to: navigation, search Federal Oil and Gas Regulation This is the "Federal Oil and Gas Regulation" form. To create a page with this form, enter...

  8. Title 48 CFR 1 Federal Acquisition Regulations System | Open...

    Open Energy Info (EERE)

    8 CFR 1 Federal Acquisition Regulations System Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- Federal RegulationFederal Regulation: Title 48 CFR...

  9. Idaho IS 61 Public Utility Regulation | Open Energy Information

    Open Energy Info (EERE)

    Regulation (2013). Retrieved from "http:en.openei.orgwindex.php?titleIdahoIS61PublicUtilityRegulation&oldid722586" Feedback Contact needs updating Image needs...

  10. New Mexico Public Regulation Commission | Open Energy Information

    Open Energy Info (EERE)

    Public Regulation Commission Name: New Mexico Public Regulation Commission Address: 33 Plaza La Prensa Place: Santa Fe, New Mexico Zip: 87507 Website: www.nmprc.state.nm.us...

  11. Guide to Federal Regulation of Sales of Imported Electricity...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... which regulate or monitor retail sales of electricity and the nature of such regulation or monitoring. E) Statute or Public Law granting Federal agency with regulatory authority. ...

  12. Guide to Federal Regulation of Sales of Imported Electricity...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the ...

  13. Comparing Emissions Benefits from Regulating Heavy Vehicle Idling...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Emissions Benefits from Regulating Heavy Vehicle Idling Comparing Emissions Benefits from Regulating Heavy Vehicle Idling 2005 Diesel Engine Emissions Reduction (DEER) Conference...

  14. Category:Federal Oil and Gas Regulations | Open Energy Information

    Open Energy Info (EERE)

    Regulations Jump to: navigation, search Add a new Federal Oil and Gas Regulation This category currently contains no pages or media. Retrieved from "http:en.openei.orgw...

  15. 5 CCR 1002-61 Colorado Discharge Permit System Regulations |...

    Open Energy Info (EERE)

    Discharge Permit System RegulationsLegal Abstract Regulations implementing the Colorado Water Quality Control Act applying to all operations discharging to waters of the state...

  16. Synthesis of segmented silica rods by growth temperature regulation...

    Office of Scientific and Technical Information (OSTI)

    silica rods by growth temperature regulation Citation Details In-Document Search Title: Synthesis of segmented silica rods by growth temperature regulation Authors: Sharma, ...

  17. June 24 Webinar Will Discuss How Environmental Laws and Regulations...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Will Discuss How Environmental Laws and Regulations Affect Tribal Energy Projects June 24 Webinar Will Discuss How Environmental Laws and Regulations Affect Tribal Energy...

  18. SERN Policy and Regulation Database | Open Energy Information

    Open Energy Info (EERE)

    SERN Policy and Regulation Database Jump to: navigation, search Tool Summary Name: SERN Policy and Regulation Database AgencyCompany Organization: Renewable Energy and Energy...

  19. Building Codes and Regulations for Solar Water Heating Systems...

    Office of Environmental Management (EM)

    Building Codes and Regulations for Solar Water Heating Systems Building Codes and Regulations for Solar Water Heating Systems June 24, 2012 - 1:50pm Addthis Photo Credit:...

  20. Sandia Energy - Self-Regulated Fabrication of Size-Controlled...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Self-Regulated Fabrication of Size-Controlled Quantum Nanostructures Home Highlights - Energy Research Self-Regulated Fabrication of Size-Controlled Quantum Nanostructures Previous...

  1. Regulation Indentifier Number Title/Subject/Purpose Rule Type

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1991-AB73 Property Management Regulation: Update and eliminate inconsistencies and redundancies in DOE's personal property management regulations at 41 CFR 109. NOPR Drafting 1991...

  2. EO 13211: Regulations That Significantly Affect Energy Supply...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EO 13211: Regulations That Significantly Affect Energy Supply, Distribution, or Use EO 13211: Regulations That Significantly Affect Energy Supply, Distribution, or Use I am...

  3. Renewable Energy Terms of Reference: Laws, Policies and Regulations...

    Open Energy Info (EERE)

    Laws, Policies and Regulations Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Renewable Energy Terms of Reference: Laws, Policies and Regulations AgencyCompany...

  4. Natural Gas Regulation - Other Gas-Related Information Sources...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Natural Gas Regulation - Other Gas-Related Information Sources Natural Gas Regulation - Other Gas-Related Information Sources The single largest source of energy information...

  5. Using regulations.gov to find dockets and documents

    Broader source: Energy.gov (indexed) [DOE]

    regulations.gov to find dockets and documents Regulations.gov is a web-based repository of Federal regulatory documents. Publicly accessible documents associated with DOE Appliance ...

  6. Update on Diesel Exhaust Emission Control Technology and Regulations...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Control Technology and Regulations Update on Diesel Exhaust Emission Control Technology and Regulations 2004 Diesel Engine Emissions Reduction (DEER) Conference Presentation:...

  7. QB1 - Stochastic Gene Regulation (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Conference: QB1 - Stochastic Gene Regulation Citation Details In-Document Search Title: QB1 - Stochastic Gene Regulation Summaries of this presentation are: (1) Stochastic ...

  8. Memorandum: Participation of the EM SSAB, Stakeholders, and Regulators...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Participation of the EM SSAB, Stakeholders, and Regulators in EM Budget Requests Memorandum: Participation of the EM SSAB, Stakeholders, and Regulators in EM Budget Requests From:...

  9. Notification of Regulated Waste Activity | Open Energy Information

    Open Energy Info (EERE)

    Notification of Regulated Waste Activity Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: Notification of Regulated Waste...

  10. Environmental regulations handbook for enhanced oil recovery

    SciTech Connect (OSTI)

    Madden, M.P.; Blatchford, R.P.; Spears, R.B.

    1991-12-01

    This handbook is intended to assist owners and operators of enhanced oil recovery (EOR) operations in acquiring some introductory knowledge of the various state agencies, the US Environmental Protection Agency, and the many environmental laws, rules and regulations which can have jurisdiction over their permitting and compliance activities. It is a compendium of summarizations of environmental rules. It is not intended to give readers specific working details of what is required from them, nor can it be used in that manner. Readers of this handbook are encouraged to contact environmental control offices nearest to locations of interest for current regulations affecting them.

  11. Is the price squeeze doctrine still viable in fully-regulated energy markets

    SciTech Connect (OSTI)

    Spiwak, L.J.

    1993-01-01

    Simply stated, a price squeeze occurs when a firm with monopoly power on the primary, or wholesale, level engages in a prolonged price increase that drives competitors out of the secondary, or retail level, and thereby extends its monopoly power to the secondary market. A price squeeze will not be found, however, for any short-term exercise in market power. Rather, because anticompetitive effects of a price squeeze are indirect, the price squeeze must last long enough and be severe enough to produce effects on actual or potential competition in the secondary market. In regulated electric industries, a price squeeze claim usually arises from the complex relationship between the supplier, the wholesale customer, the retail customer, and the federal and state regulators. The supplier sells electric power to both wholesale and retail customers. Wholesale transactions are regulated by federal regulators, and retail transactions are regulated at the state level. The wholesale customers in turn sell power to their retail customers. Over the last several years, there have been substantial developments in the application of the price squeeze doctrine to fully-regulated electric utilities. This article will examine the current developments in this area, and attempt to highlight the burdens potential litigants, both plaintiffs and defendants, must overcome to succeed.

  12. Src regulates the activity of SIRT2

    SciTech Connect (OSTI)

    Choi, You Hee; Kim, Hangun; Lee, Sung Ho; Jin, Yun-Hye; Lee, Kwang Youl

    2014-07-25

    Highlights: Src decreases the protein levels of Sirt2. Src inhibitor and knockdown of Src increase the protein levels of Sirt2. Src interacts with and phosphorylates Sirt2. Src regulate the activity of Sirt2. - Abstract: SIRT2 is a mammalian member of the Sirtuin family of NAD{sup +}-dependent protein deacetylases. The tyrosine kinase Src is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganization. The function of SIRT2 is modulated by post-translational modifications; however, the precise molecular signaling mechanism of SIRT2 through interactions with c-Src has not yet been established. In this study, we investigated the potential regulation of SIRT2 function by c-Src. We found that the protein levels of SIRT2 were decreased by c-Src, and subsequently rescued by the addition of a Src specific inhibitor, SU6656, or by siRNA-mediated knockdown of c-Src. The c-Src interacts with and phosphorylates SIRT2 at Tyr104. c-Src also showed the ability to regulate the deacetylation activity of SIRT2. Investigation on the phosphorylation of SIRT2 suggested that this was the method of c-Src-mediated SIRT2 regulation.

  13. Voltage regulation in linear induction accelerators

    DOE Patents [OSTI]

    Parsons, William M. (Santa Fe, NM)

    1992-01-01

    Improvement in voltage regulation in a Linear Induction Accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance.

  14. Voltage regulation in linear induction accelerators

    DOE Patents [OSTI]

    Parsons, W.M.

    1992-12-29

    Improvement in voltage regulation in a linear induction accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core is disclosed. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance. 4 figs.

  15. Coping with uncertainties of mercury regulation

    SciTech Connect (OSTI)

    Reich, K.

    2006-09-15

    The thermometer is rising as coal-fired plants cope with the uncertainties of mercury regulation. The paper deals with a diagnosis and a suggested cure. It describes the state of mercury emission rules in the different US states, many of which had laws or rules in place before the Clean Air Mercury Rule (CAMR) was promulgated.

  16. Method for regulation of plant lignin composition

    DOE Patents [OSTI]

    Chapple, Clint (West Lafayette, IN)

    1999-01-01

    A method is disclosed for the regulation of lignin composition in plant tissue. Plants are transformed with a gene encoding an active F5H gene. The expression of the F5H gene results in increased levels of syringyl monomer providing a lignin composition more easily degraded with chemicals and enzymes.

  17. 49 CFR Parts 171-177: Hazardous Materials Regulations (DOT)

    Broader source: Energy.gov [DOE]

    The U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration regulates the transport of hazardous materials through Title 49 of the Code of Federal Regulations (49 CFR), Subchapter C, "Hazardous Materials Regulations." Parts 171-177 provide general information on hazardous materials and regulation for their packaging and their shipment by rail, air, vessel, and public highway.

  18. Enforcement Regulations and Directives- Worker Safety and Health

    Broader source: Energy.gov [DOE]

    Lists worker safety and health regulations, enforceable directives, and links to enforceable consensus standard organizations.

  19. Notice of 2009 Guidance on Energy Efficiency Enforcement Regulations |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 2009 Guidance on Energy Efficiency Enforcement Regulations Notice of 2009 Guidance on Energy Efficiency Enforcement Regulations Notice - DOE Guidance on Energy Efficiency Enforcement Regulations, Federal Register Vol. 74, No. 197 October 14, 2009. This notice sets forth the Department of Energy's (DOE's) interpretation of its energy efficiency enforcement regulations. These regulations provide for manufacturer submission of compliance statements and certification reports

  20. Collegiate Wind Competition 2014 Rules and Regulations | Department of

    Office of Environmental Management (EM)

    Energy 2014 Rules and Regulations Collegiate Wind Competition 2014 Rules and Regulations This document outlines the rules and regulations for the inaugural Collegiate Wind Competition in 2014. PDF icon U.S. Department of Energy Collegiate Wind Competition 2014 Rules and Regulations More Documents & Publications Collegiate Wind Competition Rules and Regulations Team roster: Andrew Dallas, Aerospace Engineering; Mario Mondal, Aerospace Engineering; Atif Salahudeen, Aerospace Engineering;

  1. ADR Provisions in Federal Acquisition Regulation (FAR) | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy ADR Provisions in Federal Acquisition Regulation (FAR) » ADR Provisions in Federal Acquisition Regulation (FAR) ADR Provisions in Federal Acquisition Regulation (FAR) ADR Provisions in Federal Acquisition Regulation (FAR) PDF icon ADR Provisions in Federal Acquisition Regulation (FAR) More Documents & Publications Microsoft Word - ADR-Provisions-FederalAcquisitionReg.doc ACQUISITION LETTER DEAR Part 933 Microsoft Word - ACQUISITION LETTER.doc

  2. Regulation of flexible arms under gravity

    SciTech Connect (OSTI)

    De Luca, A.; Siciliano, B.

    1993-08-01

    A simple controller is presented for the regulation problem of robot arms with flexible links under gravity. It consists of a joint PD feedback plus a constant feedforward. Global asymptotic stability of the reference equilibrium state is shown under a structural assumption about link elasticity and a mild condition on the proportional gain. The result holds also in the absence of internal damping of the flexible arm. A numerical case study is presented.

  3. ADR Provisions in Federal Acquisition Regulation (FAR)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ADR Provisions in Federal Acquisition Regulation (FAR) d. Alternative means of dispute resolution. Notwithstanding any other provision of this chapter, a contractor and a contracting officer may use any alternative means of dispute resolution under subchapter IV of chapter 5 of title 5, or other mutually agreeable procedures, for resolving claims. In a case in which such alternative means of dispute resolution or other mutually agreeable procedures are used, the contractor shall certify that the

  4. Harmonization of Federal and International Regulations

    Office of Environmental Management (EM)

    DOT/PHMSA Update Michael Conroy U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration Office of Hazardous Materials Safety Radioactive Materials - 2 - HM-230 (1/26/04) Harmonized with 2000 Version of IAEA's 1996 Edition - 3 - Changes to the IAEA Regulations Since 2000 2003 Amendment 2005 Edition 2009 Edition U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration Harmonization Rulemaking (HM-250) * Harmonize with 2009 Edition of

  5. How can environmental regulations promote clean coal technology adoption in APEC developing economies?

    SciTech Connect (OSTI)

    2007-11-15

    The study examines both existing and emerging regulatory frameworks in order to determine which type of regulations that would be most effective at promoting clean coal technology adoption in development Asia Pacific Economic Co-operation (APEC) economies and would be practical to implement. regulations targeting air emissions; regulations targeting water use; and regulations concerning coal combustion by-products. When considering the potential effect of existing and new environmental regulations on the adoption of clean coal the analysis of technologies was organised into three categories: environmental control technologies; high efficiency coal combustion technologies; and carbon dioxide capture and storage (CCS). To target the recommendations towards APEC economies that would benefit the most from this analysis, the study focused on developing and transition APEC economies that are expected to rely on coal for a large part of their future generating capacity. These economies include China, Indonesia, the Philippines, the Russian Federation, Thailand, and Vietnam. ACARP provided funding to this study, under Project C15078. 10 figs., 14 tabs., 10 apps.

  6. Evolving Role of the Power Sector Regulator: A Clean Energy Regulators Initiative Report

    SciTech Connect (OSTI)

    Zinaman, O.; Miller, M.; Bazilian, M.

    2014-04-01

    This paper seeks to briefly characterize the evolving role of power sector regulation. Given current global dynamics, regulation of the power sector is undergoing dramatic changes. This transformation is being driven by various factors including technological advances and cost reductions in renewable energy, energy efficiency, and demand management; increasing air pollution and climate change concerns; and persistent pressure for ensuring sustainable economic development and increased access to energy services by the poor. These issues add to the already complex task of power sector regulation, of which the fundamental remit remains to objectively and transparently ensure least-cost service delivery at high quality. While no single regulatory task is trivial to undertake, it is the prioritization and harmonization of a multitude of objectives that exemplifies the essential challenge of power sector regulation. Evolving regulatory roles can be understood through the concept of existing objectives and an additional layer of emerging objectives. Following this categorization, we describe seven existing objectives of power sector regulators and nine emerging objectives, highlighting key challenges and outlining interdependencies. This essay serves as a preliminary installment in the Clean Energy Regulatory Initiative (CERI) series, and aims to lay the groundwork for subsequent reports and case studies that will explore these topics in more depth.

  7. Colorado Parks and Wildlife Rules and Regulations | Open Energy...

    Open Energy Info (EERE)

    Rules and Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Colorado Parks and Wildlife Rules and Regulations Abstract This web page lists...

  8. Medical and biofuel advances possible with new gene regulation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Medical and biofuel advances possible with new gene regulation tool Medical and biofuel advances possible with new gene regulation tool The key is a tunable switch made from a ...

  9. 5 CCR 1002-64 Biosolids Regulation | Open Energy Information

    Open Energy Info (EERE)

    to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: 5 CCR 1002-64 Biosolids RegulationLegal Abstract Regulations implementing the Colorado...

  10. RCRA Notification of Regulated Waste Activity (EPA Form 8700...

    Open Energy Info (EERE)

    Notification of Regulated Waste Activity (EPA Form 8700-12) Jump to: navigation, search OpenEI Reference LibraryAdd to library Form: RCRA Notification of Regulated Waste Activity...

  11. Self-regulating flow control device

    DOE Patents [OSTI]

    Humphreys, Duane A. (Pittsburgh, PA)

    1984-01-01

    A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.

  12. QB1 - Stochastic Gene Regulation Munsky, Brian [Los Alamos National

    Office of Scientific and Technical Information (OSTI)

    FACILITIES; FLUCTUATIONS; GENE REGULATION; KINETICS; QUANTIZATION; SIMULATION; SWITCHES Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present...

  13. Re: Request for Information on Regulatory Burden of DOE Regulations |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Request for Information on Regulatory Burden of DOE Regulations Re: Request for Information on Regulatory Burden of DOE Regulations Comments from Edison Electric Institute on DOE's Request for Information regarding the burden of DOE regulations. PDF icon Re: Request for Information on Regulatory Burden of DOE Regulations More Documents & Publications Edison Electric Institute (EEI) Reducing Regulatory Burden RFI, 77 Fed. Reg. 28518 (May 15, 2012) Comments on Docket

  14. Method to determine transcriptional regulation pathways in organisms

    Office of Scientific and Technical Information (OSTI)

    (Patent) | SciTech Connect Method to determine transcriptional regulation pathways in organisms Citation Details In-Document Search Title: Method to determine transcriptional regulation pathways in organisms The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for

  15. Contacts for the Assistant General Counsel for Legislation, Regulation, and

    Energy Savers [EERE]

    Energy Efficiency | Department of Energy Legislation, Regulation, and Energy Efficiency Contacts for the Assistant General Counsel for Legislation, Regulation, and Energy Efficiency Office of the Assistant General Counsel for Legislation, Regulation & Energy Efficiency (GC-33) Daniel Cohen, Assistant General Counsel for Legislation, Regulation, & Energy Efficiency 202-586-9523 daniel.cohen@hq.doe.gov Catherine Goshe, Attorney-Adviser 202-586-7053 Preeti Chaudhari, Attorney-Adviser

  16. Federal Register Notices for DOE NEPA Guidelines and Regulations |

    Office of Environmental Management (EM)

    Department of Energy Notices for DOE NEPA Guidelines and Regulations Federal Register Notices for DOE NEPA Guidelines and Regulations Historical compilation of Federal Register notices for DOE NEPA guidelines and regulations. PDF icon DOE-NEPA-Guidelines-and-Regulations--1978-2011.pdf More Documents & Publications DOE NEPA Guidance and Requirements - Search Index - List of Contents EPA's Section 309 Review: The Clean Air Act and NEPA EPA's Section 309 Review: The Clean Air Act and NEPA

  17. Code of Federal Regulations NUCLEAR SAFETY MANAGEMENT | Department of

    Office of Environmental Management (EM)

    Energy NUCLEAR SAFETY MANAGEMENT Code of Federal Regulations NUCLEAR SAFETY MANAGEMENT This part governs the conduct of DOE contractors, DOE personnel, and other persons conducting activities (including providing items and services) that affect, or may affect, the safety of DOE nuclear facilities. PDF icon Code of Federal Regulations NUCLEAR SAFETY MANAGEMENT More Documents & Publications Code of Federal Regulations TRESPASSING ON DEPARTMENT OF ENERGY PROPERTY Code of Federal Regulations

  18. NARUC Releases Cybersecurity Primer for Utility Regulators (June 2012) |

    Office of Environmental Management (EM)

    Department of Energy NARUC Releases Cybersecurity Primer for Utility Regulators (June 2012) NARUC Releases Cybersecurity Primer for Utility Regulators (June 2012) June 14, 2012 - 4:50pm Addthis The National Association of Regulatory Utility Commissioners (NARUC) has released "Cybersecurity for State Regulators," a primer that explains conceptual cybersecurity basics and points to additional resources that can help regulators develop internal cybersecurity expertise, ask questions

  19. EA-1631: Beacon Power Corporation Frequency Regulation Facility in

    Office of Environmental Management (EM)

    Stephentown, NY | Department of Energy 1: Beacon Power Corporation Frequency Regulation Facility in Stephentown, NY EA-1631: Beacon Power Corporation Frequency Regulation Facility in Stephentown, NY February 2, 2009 EA-1631: Final Environmental Assessment Loan Guarantee for Beacon Power Corporation Frequency Regulation Facility in Stephentown, New York February 27, 2009 EA-1631: Finding of No Significant Impact Loan Guarantee for Beacon Power Corporation Frequency Regulation Facility in

  20. Dancing with the regulations - Part Deux

    SciTech Connect (OSTI)

    Nitschke, R.L.

    1995-12-31

    The disposal of low-level radioactive waste (LLW) in the United States has long been subjected to two very similar regulations depending upon the location. Disposal sites located on Department of Energy (DOE) Reservations are subject to DOE Order 5820.2A {open_quotes}Radioactive Waste Management,{close_quotes} while disposal sites located elsewhere are subject to the Nuclear Regulatory Commission regulation 10 CFR 61 {open_quotes}Licensing Requirements for Land Disposal of Radioactive Waste.{close_quotes} While life was not necessarily good, there was only one sheet of music to dance to. Recently a new player, named CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act), has ridden into those DOE towns, and for those whose disposal facilities lie within or adjacent to Superfund sites, she has brought along a different drum to dance to. This paper discusses the differences and similarities between the different dance partners and their associated musical scores (i.e., the performance assessment (PA) required by the DOE order and the baseline risk assessment (BRA) required by CERCLA). The paper then provides a brief discussion on the latest dancer to cut in: the Defense Nuclear Facilities Safety Board (DNFSB). This discussion should help to alleviate the confusion while dancing on the LLW disposal regulatory ballroom floor.

  1. Insight in the multilevel regulation of NER

    SciTech Connect (OSTI)

    Dijk, Madelon; Typas, Dimitris; Mullenders, Leon; Pines, Alex

    2014-11-15

    Nucleotide excision repair (NER) is a key component of the DNA damage response (DDR) and it is essential to safeguard genome integrity against genotoxic insults. The regulation of NER is primarily mediated by protein post-translational modifications (PTMs). The NER machinery removes a wide spectrum of DNA helix distorting lesions, including those induced by solar radiation, through two sub-pathways: global genome nucleotide excision repair (GG-NER) and transcription coupled nucleotide excision repair (TC-NER). Severe clinical consequences associated with inherited NER defects, including premature ageing, neurodegeneration and extreme cancer-susceptibility, underscore the biological relevance of NER. In the last two decades most of the core NER machinery has been elaborately described, shifting attention to molecular mechanisms that either facilitate NER in the context of chromatin or promote the timely and accurate interplay between NER factors and various post-translational modifications. In this review, we summarize and discuss the latest findings in NER. In particular, we focus on emerging factors and novel molecular mechanisms by which NER is regulated.

  2. Implementation plan for Title 40 Code of Federal Regulations Parts 280 and 281; Final rules for underground storage tanks

    SciTech Connect (OSTI)

    Stupka, R.C.

    1989-04-01

    This report presents the schedules and methods required to comply with the newly promulgated Underground Storage Tank (UST) Regulations Title 40 Code of Federal Regulations (CFR) 280 and 281. These rules were promulgated by the US Environmental Protection Agency (EPA) on September 23, 1988, and became effective December 22, 1988. These regulations are required by Subtitle I of the Resource Conservation and Recovery Act of 1976. Their purpose is to protect the groundwater supplies of the United States in the following ways: Closing old tanks; detecting and remediating tank leaks and spills; establishing stringent standards for new tanks; and upgrade of existing tanks to new-tank standards. 3 refs., 5 tabs.

  3. Conditions for establishing quasistable double layers in the Earth's auroral upward current region

    SciTech Connect (OSTI)

    Main, D. S.; Newman, D. L.; Ergun, R. E.

    2010-12-15

    The strength and stability of simulated double layers at the ionosphere-auroral cavity boundary have been studied as a function of cold ionospheric electron temperature and density. The simulations are performed with an open boundary one-dimensional particle-in- cell (PIC) simulation and are initialized by imposing a density cavity within the simulation domain. The PIC simulation includes H{sup +} and O{sup +} ion beams, a hot H{sup +} background population, cold ionospheric electrons, and a hot electron population. It is shown that a double layer remains quasistable for a variety of initial conditions and plasma parameters. The average potential drop of the double layer is found to increase as the cold electron temperature decreases. However, in terms of cold electron density, the average potential drop of the double layer is found to increase up to some critical cold electron density and decreases above this value. Comparisons with FAST observations are made and agreement is found between simulation results and observations in the shape and width of the double layer. This study helps put a constraint on the plasma conditions in which a DL can be expected to form and remain quasistable.

  4. Energy conversion system involving change in the density of an upwardly moving liquid

    DOE Patents [OSTI]

    Petrick, Michael (Jolliet, IL)

    1989-01-01

    A system for converting thermal energy into electrical energy includes a fluid reservoir, a relatively high boiling point fluid such as lead or a lead alloy within the reservoir, a downcomer defining a vertical fluid flow path communicating at its upper end with the reservoir and an upcomer defining a further vertical fluid flow path communicating at its upper end with the reservoir. A variable area nozzle of rectangular section may terminate the upper end of the upcomer and the lower end of the of the downcomer communicates with the lower end of the upcomer. A mixing chamber is located at the lower end portion of the upcomer and receives a second relatively low boiling point fluid such as air, the mixing chamber serving to introduce the low boiling point fluid into the upcomer so as to produce bubbles causing the resultant two-phase fluid to move at high velocity up the upcomer. Means are provided for introducing heat into the system preferably between the lower end of the downcomer and the lower end of the upcomer. Power generating means are associated with the one of the vertical fluid flow paths one such power generating means being a magneto hydrodynamic electrical generator.

  5. Do Coupled Climate Models Correctly SImulate the Upward Branch of the Deept Ocean Global Conveyor?

    SciTech Connect (OSTI)

    Sarmiento, Jorge L; Downes, Stephanie; Bianchi, Daniele

    2013-01-17

    The large-scale meridional overturning circulation (MOC) connects the deep ocean, a major reservoir of carbon, to the other components of the climate system and must therefore be accurately represented in Earth System Models. Our project aims to address the specific question of the pathways and mechanisms controlling the upwelling branch of the MOC, a subject of significant disagreement between models and observational syntheses, and among general circulation models. Observations of these pathways are limited, particularly in regions of complex hydrography such as the Southern Ocean. As such, we rely on models to examine theories of the overturning circulation, both physically and biogeochemically. This grant focused on a particular aspect of the meridional overturning circulation (MOC) where there is currently significant disagreement between models and observationally based analyses of the MOC, and amongst general circulation models. In particular, the research focused on addressing the following questions: 1. Where does the deep water that sinks in the polar regions rise to the surface? 2. What processes are responsible for this rise? 3. Do state-of-the-art coupled GCMs capture these processes? Our research had three key components: observational synthesis, model development and model analysis. In this final report we outline the key results from these areas of research for the 2007 to 2012 grant period. The research described here was carried out primarily by graduate student, Daniele Bianchi (now a Postdoc at McGill University, Canada), and Postdoc Stephanie Downes (now a Research Fellow at The Australian national University, Australia). Additional support was provided for programmers Jennifer Simeon as well as Rick Slater.

  6. Upward-facing Lithium Flash Evaporator for NSTX-U (Conference...

    Office of Scientific and Technical Information (OSTI)

    The minimal time interval between the evaporation andmore the start of the discharge will avoid the passivation of the lithium by residual gases and enable the study of the ...

  7. Is anyone regulating naturally occurring radioactive material? A state survey

    SciTech Connect (OSTI)

    Gross, E.M.; Barisas, S.G.

    1993-08-01

    As far as we know, naturally occurring radioactive material (NORM) has surrounded humankind since the beginning of time. However, recent data demonstrating that certain activities concentrate NORM have increased concern regarding its proper handling and disposal and precipitated the development of new NORM-related regulations. The regulation of NORM affects the management of government facilities as well as a broad range of industrial processes. Recognizing that NORM regulation at the federal level is extremely limited, Argonne National Laboratory (ANL) conducted a 50-state survey to determine the extent to which states have assumed the responsibility for regulating NORM as well as the NORM standards that are currently being applied at the state level. Though the survey indicates that NORM regulation comprises a broad spectrum of controls from full licensing requirements to virtually no regulation at afl, a trend is emerging toward recognition of the need for increased regulation of potential NORM hazards, particularly in the absence of federal standards.

  8. Transcriptomic analysis in the developing zebrafish embryo after compound exposure: Individual gene expression and pathway regulation

    SciTech Connect (OSTI)

    Hermsen, Sanne A.B.; Pronk, Tessa E.; Brandhof, Evert-Jan van den; Ven, Leo T.M. van der; Piersma, Aldert H.

    2013-10-01

    The zebrafish embryotoxicity test is a promising alternative assay for developmental toxicity. Classically, morphological assessment of the embryos is applied to evaluate the effects of compound exposure. However, by applying differential gene expression analysis the sensitivity and predictability of the test may be increased. For defining gene expression signatures of developmental toxicity, we explored the possibility of using gene expression signatures of compound exposures based on commonly expressed individual genes as well as based on regulated gene pathways. Four developmental toxic compounds were tested in concentration-response design, caffeine, carbamazepine, retinoic acid and valproic acid, and two non-embryotoxic compounds, D-mannitol and saccharin, were included. With transcriptomic analyses we were able to identify commonly expressed genes, which were mostly development related, after exposure to the embryotoxicants. We also identified gene pathways regulated by the embryotoxicants, suggestive of their modes of action. Furthermore, whereas pathways may be regulated by all compounds, individual gene expression within these pathways can differ for each compound. Overall, the present study suggests that the use of individual gene expression signatures as well as pathway regulation may be useful starting points for defining gene biomarkers for predicting embryotoxicity. - Highlights: The zebrafish embryotoxicity test in combination with transcriptomics was used. We explored two approaches of defining gene biomarkers for developmental toxicity. Four compounds in concentration-response design were tested. We identified commonly expressed individual genes as well as regulated gene pathways. Both approaches seem suitable starting points for defining gene biomarkers.

  9. When regulations go too far the taking of private property by environmental regulations

    SciTech Connect (OSTI)

    Plott, D.M.

    1995-12-01

    Seventy years ago Justice Oliver Wendell Homes wrote in an Opinion of the United States Supreme Court that{open_quotes}...while property may be regulated to a certain extent, if regulation goes too far it will be recognized as a taking.{close_quotes} Pennsylvania Coal Co. v. Mahon, 260 U.S. 393 (1992) The Fifth Amendment of the United States Constitution provides that private property shall not be {open_quotes}taken for public use, without just compensation{close_quotes}. After lying dormant for half a century, the {open_quotes}takings{close_quotes} clause of the United States constitution is being invoked to challenge environmental regulations throughout the country. In essence, property owners are saying that if the government wants to regulate to protect wetlands, wildlife habitat and other natural resources it must pay just compensation to the property owners for the restrictions imposed upon the use of their land. During the past ten years, the U.S. Supreme Court has decided several takings cases. While the judicial branch of government has become increasingly active in takings cases, the U.S. Congress and State legislatures have also been extremely active in efforts to protect private property rights. Typically, these legislative requires a takings impact analysis by the government to determine if its actions are likely to result in the compensable taking of private property or require compensation if property values are reduced by a certain percentage. This paper reviews the judicial standards that have been established for reviewing taking claims and sets forth a framework for analyzing when a regulation goes {open_quotes}too far{close_quotes} so as to require payment of compensation.

  10. Economics and regulation of petroleum futures markets

    SciTech Connect (OSTI)

    Not Available

    1980-08-01

    Because the futures market in petroleum products is a relatively recent phenomenon, the implications of public policies formulated for that market have not yet been fully explored. To provide the Office of Competition of the Department of Energy (DOE) with sufficient information to assess policy alternatives, Resource Planning Associates, Inc. (RPA) was asked to analyze the development of the futures market in No. 2 oil, assess the potential for futures markets in other petroleum products, and identify policy alternatives available to DOE. To perform this analysis, the criteria for a viable futures market was established first. Then, the experience to date with the 18-month-old futures market in No. 2 oil was examined, and the potential for viable futures markets in No. 6 oil, gasoline, jet fuel, and crude oil was assessed. Finally, how existing DOE regulations and prospective actions might affect petroleum futures market development was investigated.

  11. System and method for regulating resonant inverters

    DOE Patents [OSTI]

    Stevanovic, Ljubisa Dragoljub (Clifton Park, NY); Zane, Regan Andrew (Superior, CO)

    2007-08-28

    A technique is provided for direct digital phase control of resonant inverters based on sensing of one or more parameters of the resonant inverter. The resonant inverter control system includes a switching circuit for applying power signals to the resonant inverter and a sensor for sensing one or more parameters of the resonant inverter. The one or more parameters are representative of a phase angle. The resonant inverter control system also includes a comparator for comparing the one or more parameters to a reference value and a digital controller for determining timing of the one or more parameters and for regulating operation of the switching circuit based upon the timing of the one or more parameters.

  12. Educational program on potential impacts of regulated underground storage tanks

    SciTech Connect (OSTI)

    Titus, E.W.

    1995-12-01

    This paper defines a brief (three to four hours) and effective method of educating future environmental professionals, concerned citizens of the community, or local government officials about the long term residual contamination potential posed by underground storage tank sites (UST`s). The format will be designed so that the student will have a clear understanding of the function and capabilities of UST systems, the required monitoring and maintenance, and the extensive commitments necessary to remediate a contaminated site. Subject material covered will include regulation overview, system design and installation, current remediation technologies and future trends. The curriculum will be presented in lecture/workshop format, and will feature color photographs, sites studies and relevant maps. Hypothetical statistical and chemical analytical results will be supplied for interpretation. The student will synthesize, in participatory work groups, the information using some of the various types of UST evaluation systems and formats currently in use by the individual states. This approach exposes the student to participatory group planning and decision making. This type of learning experience would be of significant value because UST`s have left an indelible mark on many street corners across the country. A variety of factors, such as population shifts from urban to suburban areas, governmental regulations, and overhead costs, caused many business owners to want to close their existing UST sites and sell the property. With these closed or abandoned sites comes the potential for soil and groundwater contamination due to petroleum product spillage, or leaking UST`s still under the surface of the site. The goal of this comprehensive approach is to enable the student to make informed judgements as to both the current and long term risks of UST systems. As an additional benefit these individuals will gain a better understanding about their local environment.

  13. Colorado geothermal institutional handbook: a user's guide of agencies regulations, permits, and aids for geothermal development

    SciTech Connect (OSTI)

    Coe, B.A.; Forman, N.A.

    1980-01-01

    The following are included: principal state agencies, applicable state legislation, applicable state regulations, local agencies and regulations, federal agencies and regulations, information sources, and agencies and individuals. (MHR)

  14. Alaska - 3 AAC 48.280 Notice and Effective Date | Open Energy...

    Open Energy Info (EERE)

    OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Alaska - 3 AAC 48.280 Notice and Effective DateLegal Abstract This section outlines the notice...

  15. Title 43 CFR 1610.4-6 Estimation of Effects of Alternatives ...

    Open Energy Info (EERE)

    4-6 Estimation of Effects of Alternatives Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- Federal RegulationFederal Regulation: Title 43 CFR...

  16. Incentive regulation of investor-owned nuclear power plants by public utility regulators. Revision 1

    SciTech Connect (OSTI)

    McKinney, M.D.; Seely, H.E.; Merritt, C.R.; Baker, D.C.

    1995-04-01

    The US Nuclear Regulatory Commission (NRC) periodically surveys the Federal Energy Regulatory Commission (FERC) and state regulatory commissions that regulate utility owners of nuclear power plants. The NRC is interested in identifying states that have established economic or performance incentive programs applicable to nuclear power plants, how the programs are being implemented, and in determining the financial impact of the programs on the utilities. The NRC interest stems from the fact that such programs have the potential to adversely affect the safety of nuclear power plants. The current report is an update of NUREG/CR-5975, Incentive Regulation of Investor-Owned Nuclear Power Plants by Public Utility Regulators, published in January 1993. The information in this report was obtained from interviews conducted with each state regulatory agency that administers an incentive program and each utility that owns at least 10% of an affected nuclear power plant. The agreements, orders, and settlements that form the basis for each incentive program were reviewed as required. The interviews and supporting documentation form the basis for the individual state reports describing the structure and financial impact of each incentive program.

  17. Key Publications - Natural Gas Regulation | Department of Energy

    Energy Savers [EERE]

    Services » Natural Gas Regulation » Key Publications - Natural Gas Regulation Key Publications - Natural Gas Regulation Natural Gas Imports and Exports - Quarterly Reports February 3, 2016 Natural Gas Imports and Exports Third Quarter Report 2015 October 30, 2015 Natural Gas Imports and Exports Second Quarter Report 2015 August 13, 2015 Natural Gas Imports and Exports First Quarter Report 2015 May 28, 2015 Natural Gas Imports and Exports Fourth Quarter Report 2014 More Quarterly Reports LNG

  18. Energy Department Revises NEPA Regulations to Improve Efficiency |

    Energy Savers [EERE]

    Department of Energy Revises NEPA Regulations to Improve Efficiency Energy Department Revises NEPA Regulations to Improve Efficiency October 3, 2011 - 12:39pm Addthis Washington, D.C. -- The U.S. Department of Energy will save time and money in its environmental reviews of many proposed energy projects under revised regulations approved September 27, 2011, to implement the National Environmental Policy Act (NEPA). The revisions focus on the Department's categorical exclusion provisions, and

  19. Estrogen induced {beta}-1,4-galactosyltransferase 1 expression regulates

    Office of Scientific and Technical Information (OSTI)

    proliferation of human breast cancer MCF-7 cells (Journal Article) | SciTech Connect Estrogen induced {beta}-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells Citation Details In-Document Search Title: Estrogen induced {beta}-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells Highlights: Black-Right-Pointing-Pointer We examined the regulation and biological functions of B4GALT1 expression induced

  20. Contacts for the Deputy General Counsel for Litigation, Regulation and

    Energy Savers [EERE]

    Enforcement (GC-30) | Department of Energy Litigation, Regulation and Enforcement (GC-30) Contacts for the Deputy General Counsel for Litigation, Regulation and Enforcement (GC-30) Anne Harkavy, Deputy General Counsel for Litigation, Regulation, and Enforcement 202-586-8700 anne.harkavy@hq.doe.gov Margie L. Washington, Administrative Support Specialist 202-586-8700 202-586-3437 (fax) margie.washington@hq.doe.gov

  1. Opportunities for improving regulations governing the seismic safety of

    Office of Environmental Management (EM)

    large nuclear installations | Department of Energy Opportunities for improving regulations governing the seismic safety of large nuclear installations Opportunities for improving regulations governing the seismic safety of large nuclear installations Opportunities for Improving Regulations Governing the Seismic Safety of Large Nuclear Installations Robert J. Budnitz, Ph.D. LBNL University of California, Berkeley, CA 94720 Andrew S. Whittaker, Ph.D., S.E. MCEER University at Buffalo, Buffalo,

  2. Environmental Regulations and Changes in Petroleum Refining Operations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulations and Changes in Petroleum Refining Operations By Tancred C.M. Lidderdale Contents * Introduction * Motor Gasoline Summer Volatility (RVP) Regulations o Table 1. Summer Volatility Regulations for Motor Gasoline o Table 2. Refinery Inputs and Production of Normal Butane o Figure 1. Refinery Inputs and Production of Normal Butane o Table 3. Price Relationship Between Normal Butane and Motor Gasoline o Table 4. Market Price Premium for Low Vapor Pressure (RVP) Gasoline * Oxygenate Content

  3. Regulation-1 Wholesale Power Rate Schedule | Department of Energy

    Energy Savers [EERE]

    Regulation-1 Wholesale Power Rate Schedule Regulation-1 Wholesale Power Rate Schedule Area: Regulation Services System: Georgia-Alabama-South Carolina This rate schedule shall be available to public bodies and cooperatives (any one of whom is hereinafter called the Customer) in Georgia, Alabama, Mississippi, Florida, South Carolina, or North Carolina to whom service is provided pursuant to contracts between the Government and the Customer. This rate schedule shall be applicable to the sale of

  4. Harmonization of Federal and International Regulations | Department of

    Energy Savers [EERE]

    Energy Harmonization of Federal and International Regulations Harmonization of Federal and International Regulations Update of the U.S. Department of Transportation (DOT) Pipeline and Hazardous Materials Safety Administration (PHMSA). PDF icon Harmonization of Federal and International Regulations More Documents & Publications Department of Transportation Pipeline and Hazardous Materials Safety Administration Activities DOE-STD-5507-2013 FAQS Reference Guide - NNSA Package Certification

  5. Building Codes and Regulations for Solar Water Heating Systems | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Codes and Regulations for Solar Water Heating Systems Building Codes and Regulations for Solar Water Heating Systems Photo Credit: iStockphoto Photo Credit: iStockphoto Before installing a solar water heating system, you should investigate local building codes, zoning ordinances, and subdivision covenants, as well as any special regulations pertaining to the site. You will probably need a building permit to install a solar energy system onto an existing building. Not every

  6. Office of the Assistant General Counsel for Legislation, Regulation and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Efficiency | Department of Energy Legislation, Regulation and Energy Efficiency Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency The Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency (GC-33) provides legal support and advice on legislative matters throughout the Department. It participates in the development of DOE views on pending legislation, drafts DOE legislative proposals and supporting documents,

  7. Vehicle Technologies Office: Regulated Fleets | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Alternative Fuels » Vehicle Technologies Office: Regulated Fleets Vehicle Technologies Office: Regulated Fleets The Office of Energy Efficiency and Renewable Energy (EERE) manages several programs designed to fulfill the requirements of the original and amended versions of the Energy Policy Act of 1992 (EPAct) that regulate and guide specific types of fleets with the goal of reducing the United States' petroleum consumption. EERE's Vehicle Technologies Office (VTO) implements the EPAct

  8. Homeobox A7 stimulates breast cancer cell proliferation by up-regulating estrogen receptor-alpha

    SciTech Connect (OSTI)

    Zhang, Yu; Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4 ; Cheng, Jung-Chien; Huang, He-Feng; Leung, Peter C.K.

    2013-11-01

    Highlights: HOXA7 regulates MCF7 cell proliferation. HOXA7 up-regulates ER? expression. HOXA7 mediates estrogen-induced MCF7 cell proliferation. -- Abstract: Breast cancer is the most common hormone-dependent malignancy in women. Homeobox (HOX) transcription factors regulate many cellular functions, including cell migration, proliferation and differentiation. The aberrant expression of HOX genes has been reported to be associated with human reproductive cancers. Estradiol (E2) and its nuclear receptors, estrogen receptor (ER)-alpha and ER-beta, are known to play critical roles in the regulation of breast cancer cell growth. However, an understanding of the potential relationship between HOXA7 and ER in breast cancer cells is limited. In this study, our results demonstrate that knockdown of HOXA7 in MCF7 cells significantly decreased cell proliferation and ER? expression. In addition, HOXA7 knockdown attenuated E2-induced cell proliferation as well as progesterone receptor (PR) expression. The stimulatory effects of E2 on cell proliferation and PR expression were abolished by co-treatment with ICI 182780, a selective ER? antagonist. In contrast, overexpression of HOXA7 significantly stimulated cell proliferation and ER? expression. Moreover, E2-induced cell proliferation, as well as PR expression, was enhanced by the overexpression of HOXA7. Neither knockdown nor overexpression of HOXA7 affected the ER-beta levels. Our results demonstrate a novel mechanistic role for HOXA7 in modulating breast cancer cell proliferation via regulation of ER? expression. This finding contributes to our understanding of the role HOXA7 plays in regulating the proliferation of ER-positive cancer cells.

  9. Distribution System Voltage Regulation by Distributed Energy Resources

    SciTech Connect (OSTI)

    Ceylan, Oguzhan; Liu, Guodong; Xu, Yan; Tomsovic, Kevin

    2014-01-01

    This paper proposes a control method to regulate voltages in 3 phase unbalanced electrical distribution systems. A constrained optimization problem to minimize voltage deviations and maximize distributed energy resource (DER) active power output is solved by harmony search algorithm. IEEE 13 Bus Distribution Test System was modified to test three different cases: a) only voltage regulator controlled system b) only DER controlled system and c) both voltage regulator and DER controlled system. The simulation results show that systems with both voltage regulators and DER control provide better voltage profile.

  10. Geothermal Regulations in Colorado - Land Ownership is the Key...

    Open Energy Info (EERE)

    Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Paper: Geothermal Regulations in Colorado - Land Ownership is the Key Abstract Geothermal resources in...

  11. USACE Engineer Regulation 1110-2-1454 Corps Responsibilities...

    Open Energy Info (EERE)

    USACE Engineer Regulation 1110-2-1454 Corps Responsibilities for Non-Federal Hydroelectric Power Development under the Federal Power Act Jump to: navigation, search OpenEI...

  12. Acquisition Guide Chapter 1.1 - Acquisition Regulations System...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Documents & Publications Acquisition Guide Chapter 1.0 - Acquisition Regulations System Acquisition Guide Chapter 1.2 - Balanced Scorecard Performance Assessment Program - (March...

  13. Method to determine transcriptional regulation pathways in organisms...

    Office of Scientific and Technical Information (OSTI)

    The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory ...

  14. Applicable EPA Regulations and Description Website | Open Energy...

    Open Energy Info (EERE)

    provides information regarding EPA regulations that apply to brownfields grants. Author Environmental Protection Agency Published EPA, Date Not Provided DOI Not Provided Check...

  15. Council on Environmental Quality (CEQ) NEPA Regulations: 40 CFR...

    Open Energy Info (EERE)

    LibraryAdd to library Legal Document- Secondary Legal SourceSecondary Legal Source: Council on Environmental Quality (CEQ) NEPA Regulations: 40 CFR 1500 - 1518Legal Author CEQ...

  16. Biomass Boiler and Furnace Emissions and Safety Regulations in...

    Open Energy Info (EERE)

    in the Northeast States Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Biomass Boiler and Furnace Emissions and Safety Regulations in the Northeast States Agency...

  17. TEEIC Laws and Regulations Applicable to Energy Transmission...

    Open Energy Info (EERE)

    TEEIC Laws and Regulations Applicable to Energy Transmission Development Website Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: TEEIC Laws and...

  18. Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A - General Provisions The rules in this part establish radiation protection standards, limits, and ...

  19. Comments Received on Proposed Rulemaking for regulation implementing...

    Office of Environmental Management (EM)

    section 216(h): Coordination of Federal Transmission Permitting on Federal Lands Comments Received on Proposed Rulemaking for regulation implementing section 216(h): Coordination ...

  20. Technical Demonstration of 2010 Emissions Regulations over Transient...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    at EPA 2010 Emissions Regulations NAFTA Heavy Duty Engine and Aftertreatment Technology: Status and Outlook Integration of Control System Components for Optimum Engine Response...

  1. A Regulator's Perspective on Interpretation of Performance and...

    Office of Environmental Management (EM)

    Interpretation of Performance and Risk Assessment Results A Regulator's Perspective on Interpretation of Performance and Risk Assessment Results Presentation from the 2015 Annual...

  2. A Utility Regulator's Guide to Data Access for Commercial Building...

    Broader source: Energy.gov (indexed) [DOE]

    use data to help commercial customers manage energy costs through building energy benchmarking. A Utility Regulator's Guide to Data Access for Commercial Building Energy...

  3. Control and regulation of modern distribution system, ForskEL...

    Open Energy Info (EERE)

    system, ForskEL (Smart Grid Project) Jump to: navigation, search Project Name Control and regulation of modern distribution system, ForskEL Country Denmark Coordinates...

  4. Chapter 1 of the Wyoming Public Service Commission Regulations...

    Open Energy Info (EERE)

    of the Wyoming Public Service Commission Regulations: Rules of Practice and Procedure Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  5. Standards for Municipal Small Wind Regulations and Model Ordinance

    Broader source: Energy.gov [DOE]

    In July 2008, New Hampshire enacted legislation designed to prevent municipalities from adopting ordinances or regulations that place unreasonable limits on or hinder the performance of wind energy...

  6. Strategic Energy Management for Regulators of Ratepayer-Funded Programs

    SciTech Connect (OSTI)

    Existing Commercial Buildings Working Group

    2012-05-23

    Provides regulators with information on how to design and implement whole-building, continuous-improvement energy management programs for commercial buildings.

  7. Rules and Regulations of the Department of Transportation, Chapter...

    Open Energy Info (EERE)

    of Transportation, Chapter 13 - Access FacilitiesLegal Abstract This chapter sets forth Department of Transportation rules and regulations governing access facilities....

  8. Department of Energy Acquisition Regulation (DEAR) Subpart 903...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation (DEAR) Subpart 903.9: Whistleblower Protections for Contractor Employees Stakeholders: DOE Contractor employees Scope: This subpart of DEAR implements the DOE Contractor...

  9. 50 CFR 216 - Regulations Governing the Taking and Importing of...

    Open Energy Info (EERE)

    50 CFR 216 - Regulations Governing the Taking and Importing of Marine Mammals Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  10. Policy Flash 2013-23 Department of Energy Acquisition Regulation...

    Broader source: Energy.gov (indexed) [DOE]

    Attached is Policy Flash 2013-23 Department of Energy Acquisition Regulation (DEAR) Final Rule for changes to Parts 908, 945, 952, and 970 regarding Government Property. Questions...

  11. System Effectiveness

    SciTech Connect (OSTI)

    Powell, Danny H; Elwood Jr, Robert H

    2011-01-01

    An effective risk assessment system is needed to address the threat posed by an active or passive insider who, acting alone or in collusion, could attempt diversion or theft of nuclear material. It is critical that a nuclear facility conduct a thorough self-assessment of the material protection, control, and accountability (MPC&A) system to evaluate system effectiveness. Self-assessment involves vulnerability analysis and performance testing of the MPC&A system. The process should lead to confirmation that mitigating features of the system effectively minimize the threat, or it could lead to the conclusion that system improvements or upgrades are necessary to achieve acceptable protection against the threat. Analysis of the MPC&A system is necessary to understand the limits and vulnerabilities of the system to internal threats. Self-assessment helps the facility be prepared to respond to internal threats and reduce the risk of theft or diversion of nuclear material. MSET is a self-assessment or inspection tool utilizing probabilistic risk assessment (PRA) methodology to calculate the system effectiveness of a nuclear facility's MPC&A system. MSET analyzes the effectiveness of an MPC&A system based on defined performance metrics for MPC&A functions based on U.S. and international best practices and regulations. A facility's MC&A system can be evaluated at a point in time and reevaluated after upgrades are implemented or after other system changes occur. The total system or specific subareas within the system can be evaluated. Areas of potential performance improvement or system upgrade can be assessed to determine where the most beneficial and cost-effective improvements should be made. Analyses of risk importance factors show that sustainability is essential for optimal performance. The analyses reveal where performance degradation has the greatest detrimental impact on total system risk and where performance improvements have the greatest reduction in system risk. The risk importance factors show the amount of risk reduction achievable with potential upgrades and the amount of risk reduction actually achieved after upgrades are completed. Applying the risk assessment tool gives support to budget prioritization by showing where budget support levels must be sustained for MC&A functions most important to risk. Results of the risk assessment are also useful in supporting funding justifications for system improvements that significantly reduce system risk.

  12. 10 V.S.A. Chapter 41 Regulation of Stream Flow | Open Energy...

    Open Energy Info (EERE)

    1 Regulation of Stream Flow Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 10 V.S.A. Chapter 41 Regulation of Stream...

  13. Title 10 Chapter 41 Regulation of Stream Flow | Open Energy Informatio...

    Open Energy Info (EERE)

    41 Regulation of Stream Flow Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Title 10 Chapter 41 Regulation of Stream...

  14. 5 CCR 1002-82 401 Certification Regulation | Open Energy Information

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 5 CCR 1002-82 401 Certification RegulationLegal Abstract Implementing regulations that...

  15. Economizer control assembly for regulating the volume flow of outdoor ambient air

    SciTech Connect (OSTI)

    Michaels, D.D. Jr.

    1984-10-23

    An economizer assembly is disclosed wherein a sliding door is utilized for covering an outdoor ambient air opening allowing outdoor ambient air flow into a space to be conditioned. A motor shaft arrangement connected via a rotating drive rod is utilized to slidably displace the door to any position necessary to effectively regulate air flow. The utilization of this economizer control arrangement with a rooftop type air conditioning unit is further disclosed.

  16. 1995 revisions to the DOT/NRC transport regulations and their impact on nuclear power plants

    SciTech Connect (OSTI)

    Grella, A.W.

    1996-10-01

    On September 28, 1995, the U.S. Department of Transportation (DOT) and the U.S. Nuclear Regulatory Commission (NRC) published major amendments to the nuclear transportation regulations of the US. The amendments culminated an approximate 8-year effort of the two agencies to conform US regulations (to the extent practicable) to the international transport standards of the International Atomic Energy Agency (IAEA) Safety Series N. 6, {open_quotes}Regulations For The Safe Transport of Radioactive Material{close_quotes}, 1985 Edition (Revised 1990). This paper identifies the major revisions to the regulations which have taken place and discusses not only their probable future impacts but also identifies certain issues and early impacts which have been emerging since publication of the final rules late in 1995. The discussion is summarized with respect to these impacts and issues on transportation of radioactive material by the nuclear power industry. Many of the revisions which are more minor in nature are also identified. The generic effective date for mandatory compliance with the revised regulations was April 1, 1996, however two of the major revisions of interest to the utilities have later effective dates for mandatory compliance. The use of the so-called {open_quotes}NRC-Certified Type A LSA Packages{close_quotes} are authorized until April 1, 1999 and mandatory compliance with the new radiation protection program requirements of 49 CFR 172 Subpart I is not until October 1, 1997. This paper is based to a large extent on the EPRI report bearing the same title as this paper, which is currently in draft.

  17. Autonomous Demand Response for Primary Frequency Regulation

    SciTech Connect (OSTI)

    Donnelly, Matt; Trudnowski, Daniel J.; Mattix, S.; Dagle, Jeffery E.

    2012-02-28

    The research documented within this report examines the use of autonomous demand response to provide primary frequency response in an interconnected power grid. The work builds on previous studies in several key areas: it uses a large realistic model (i.e., the interconnection of the western United States and Canada); it establishes a set of metrics that can be used to assess the effectiveness of autonomous demand response; and it independently adjusts various parameters associated with using autonomous demand response to assess effectiveness and to examine possible threats or vulnerabilities associated with the technology.

  18. Effective Date:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    local regulations; (3) evaluating whether WIPP activities cause adverse environmental impacts; and (4) taking corrective action when an adverse impact on the environment is...

  19. Emerging Latin American air quality regulation

    SciTech Connect (OSTI)

    Hosmer, A.W.; Vitale, E.M.; Guerrero, C.R.; Solorzano-Vincent, L.

    1998-12-31

    Latin America is the most urbanized region in the developing world. In recent years, significant economic growth has resulted in population migration from rural areas to urban centers, as well as in a substantial rise in the standard of living within the Region. These changes have impacted the air quality of Latin American countries as increased numbers of industrial facilities and motor vehicles release pollutants into the air. With the advent of new free trade agreements such as MERCOSUR and NAFTA, economic activity and associated pollutant levels can only be expected to continue to expand in the future. In order to address growing air pollution problems, many Latin America countries including Argentina, Brazil, Chile, Columbia, Costa Rica, and Mexico have passed, or will soon pass, new legislation to develop and strengthen their environmental frameworks with respect to air quality. As a first step toward understanding the impacts that this increased environmental regulation will have, this paper will examine the regulatory systems in six Latin American countries with respect to ambient air quality and for each of these countries: review a short history of the air quality problems within the country; outline the legal and institutional framework including key laws and implementing institutions; summarize in brief the current status of the country in terms of program development and implementation; and identify projected future trends. In addition, the paper will briefly review the international treaties that have bearing on Latin American air quality. Finally, the paper will conclude by identifying and exploring emerging trends in individual countries and the region as a whole.

  20. Federal program for regulating highly hazardous materials finally takes off

    SciTech Connect (OSTI)

    Lessard, P.C. [Block Environmental Services Inc., Pleasant Hill, CA (United States)

    1996-11-01

    The Risk Management Program (RMP) rule, Section 112(r) of the Clean Air Act (CAA), was signed on May 24 and finalized on June 20. RMP is one of the most comprehensive, technically based regulatory programs for preventing, detecting and responding to accidental hazardous materials releases to have been issued in recent times. Although facilities have three years to comply, EPA estimates that the rule will affect an estimated 66,000 facilities that store highly hazardous or acutely toxic materials. The 1990 CAA Amendments are designed to prevent accidental releases of highly hazardous chemicals from stationary sources. Two significant regulatory programs that have emerged from the revised CAA are the Process Safety Management (PSM) standard and RMP. PSM is designed to protect employees and regulated by the Occupational Safety and Health Administration. RMP`s purpose is to protect the public and the environment from highly hazardous chemicals. It authorizes EPA to create a list of substances (distinct from the list generated under PSM) known to cause serious adverse effects and to implement a program for accidental chemical release prevention.

  1. Update on Diesel Exhaust Emission Control Technology and Regulations |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Control Technology and Regulations Update on Diesel Exhaust Emission Control Technology and Regulations 2004 Diesel Engine Emissions Reduction (DEER) Conference Presentation: Corning PDF icon 2004_deer_johnson2.pdf More Documents & Publications Light Duty Diesels in the United States - Some Perspectives Review of Diesel Emission Control Technology Update on Diesel Exhaust Emission Control

  2. Federal Regulations for Natural Gas Imports and Exports | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Federal Regulations for Natural Gas Imports and Exports Federal Regulations for Natural Gas Imports and Exports PDF icon Section 3 of the Natural Gas Act More Documents & Publications Appendix B Patent and copyright cases 42 USC 17013

  3. Immunities from the antitrust laws for regulated entities

    SciTech Connect (OSTI)

    Jones, M.B.

    1985-05-30

    Just as regulation is an ever-present and crucial factor in most of the day-to-day operating decisions of regulated natural gas transmission and distribution companies, it is also an important factor to consider in assessing the application of the antitrust laws to the conduct of these regulated entities. The legal guidelines are far from clear and are evolving. However, as regulated entities find themselves in an ever more competitive environment, it becomes necessary for their legal counsel to monitor closely the developments in the law concerning immunities from the antitrust laws by virtue of regulation imposed by government. The author hopes that this article will provide a useful starting point for that analysis.

  4. Voltage Regulator Chip: Power Supplies on a Chip

    SciTech Connect (OSTI)

    2010-09-01

    ADEPT Project: CPES at Virginia Tech is finding ways to save real estate on a computer's motherboard that could be used for other critical functions. Every computer processor today contains a voltage regulator that automatically maintains a constant level of electricity entering the device. These regulators contain bulky components and take up about 30% of a computer's motherboard. CPES at Virginia Tech is developing a voltage regulator that uses semiconductors made of gallium nitride on silicon (GaN-on-Si) and high-frequency soft magnetic material. These materials are integrated on a small, 3D chip that can handle the same amount of power as traditional voltage regulators at 1/10 the size and with improved efficiency. The small size also frees up to 90% of the motherboard space occupied by current voltage regulators.

  5. A regulator`s perspective on NRC`s participation in the operations & maintenance committees

    SciTech Connect (OSTI)

    Wessman, R.H.

    1996-12-01

    As a regulator fairly new to the American Society of Mechanical Engineers (ASME) Operations and Maintenance (O&M) Committee process, the author does not have a personal historical perspective as do many of the longer-term, and highly respected, members of the O&M Committee. However, as Branch Chief of the Mechanical Engineering Branch, Division of Engineering, in the Office of Nuclear Reactor Regulation at the NRC for just over two years, he has responsibility for the regulatory agency`s review of licensee actions involving the products that come from the efforts of the O&M Committee, as well as responsibility for portions of the activities of interest to other ASME Code groups such as Section III, Section XI, and Qualification of Mechanical Equipment. As a result, the author has learned a great deal about the code process in a short time. Here he gives his perspectives on the process and provides a few thoughts on the direction for the future.

  6. Environmental Stewardship: How Semiconductor Suppliers Help toMeet Energy-Efficiency Regulations and Voluntary Specifications inChina

    SciTech Connect (OSTI)

    Aizhen, Li; Fanara, Andrew; Fridley, David; Merriman, Louise; Ju,Jeff

    2007-01-15

    Recognizing the role that semiconductor suppliers can playin meeting energy-efficiency regulations and voluntary specifications,this paper provides an overview of Chinese policies and implementingbodies; a discussion of current programs, their goals, and effectiveness;and possible steps that can be taken tomeet these energy-efficiencyrequirements while also meeting products' high performance and costgoals.

  7. A primer on incentive regulation for electric utilities

    SciTech Connect (OSTI)

    Hill, L.J.

    1995-10-01

    In contemplating a regulatory approach, the challenge for regulators is to develop a model that provides incentives for utilities to engage in socially desirable behavior. In this primer, we provide guidance on this process by discussing (1) various models of economic regulation, (2) problems implementing these models, and (3) the types of incentives that various models of regulation provide electric utilities. We address five regulatory models in depth. They include cost-of-service regulation in which prudently incurred costs are reflected dollar-for-dollar in rates and four performance-based models: (1) price-cap regulation, in which ceilings are placed on the average price that a utility can charge its customers; (2) revenue-cap regulation, in which a ceiling is placed on revenues; (3) rate-of-return bandwidth regulation, in which a utility`s rates are adjusted if earnings fall outside a {open_quotes}band{close_quotes} around equity returns; and (4) targeted incentives, in which a utility is given incentives to improve specific components of its operations. The primary difference between cost-of-service and performance-based approaches is the latter sever the tie between costs and prices. A sixth, {open_quotes}mixed approach{close_quotes} combines two or more of the five basic ones. In the recent past, a common mixed approach has been to combine targeted incentives with cost-of-service regulation. A common example is utilities that are subject to cost-of-service regulation are given added incentives to increase the efficiency of troubled electric-generating units.

  8. State and federal regulation of OTEC plants in Hawaii

    SciTech Connect (OSTI)

    Keith, K.M.

    1980-09-01

    The advantages of ocean thermal energy conversion (OTEC) for Hawaii, its institutional support, projected contributions of OTEC in the future, and environmental concerns are discussed. Three experimental OTEC facilities in Hawaii are described, and the many regulations that must be observed and permits needed are described. Applicability of existing federal laws in regulating commercial-scale OTEC plants is examined, and applicable Coast Guard regulations and maritime laws are discussed briefly. Questions of state-federal relations, particularly regarding Hawaii's archipelagic claims and coastal zone, are addressed. (LEW)

  9. Industry Self-Regulation as a Means to Promote Nonproliferation

    SciTech Connect (OSTI)

    Hund, Gretchen; Elkhamri, Oksana O.

    2005-10-01

    Companies within numerous industries that have been early adopters of self-regulation concept, considering the environment and society alongside business issues, have realized several benefits and some competitive advantage while substantially improving their environmental performance. Given that proliferation prevention is also a public good, our premise is that the experience gained and lessons learned from the self-regulation initiative in other industries and more broadly in the arena of sustainable development provide a basis for examining the feasibility of developing self-regulation mechanisms applicable to industries involved with sensitive technologies (nuclear, radiological source, and other dual-use industries)

  10. Acquisition Guide Chapter 1.0 - Acquisition Regulations System | Department

    Energy Savers [EERE]

    of Energy 0 - Acquisition Regulations System Acquisition Guide Chapter 1.0 - Acquisition Regulations System PDF icon 1.1_Acquisition_Regulation_System_0.pdf PDF icon 1.2_Head_of_Contracting_Activity_(HCA)_Authority,_Functions,_and_Responsibilities_0.pdf PDF icon 1.2_Attachment_Tables_I-IV_0.pdf PDF icon 1.3_Balanced_Scorecard_Assessment_Program_0.pdf PDF icon 1.4_Establishing_the_Position_of_Source_Evaluation_Board_(SEB)_Secretariat_and_Knowledge_Manager More Documents & Publications

  11. Regulating for the long term: SMCRA and acid mine drainage

    SciTech Connect (OSTI)

    Shea, C.W.

    1995-12-31

    With the passage of the Surface Mining Control and Reclamation Act of 1977 (SMCRA), regulators and industry representatives expected to solve the problem of pollution of the Nation`s waterways caused by acidic discharges from coal mines. Eighteen years after the passage of SMCRA, hard issues of predicting, regulating and treating acid mine drainage remain. Acid mine drainage is most common in the coal seams of the Midwest and Appalachia: Pennsylvania, West Virginia, Maryland, Ohio, Illinois, and Tennessee. This article discusses regulation of coal mines and acid mine drainage for the long term.

  12. Evaluation of phase change materials for thermal regulation enhancement of building integrated photovoltaics

    SciTech Connect (OSTI)

    Hasan, A.; Norton, B.; McCormack, S.J.; Huang, M.J.

    2010-09-15

    Regulating the temperature of building integrated photovoltaics (BIPV) using phase change materials (PCMs) reduces the loss of temperature dependent photovoltaic (PV) efficiency. Five PCMs were selected for evaluation all with melting temperatures {proportional_to}25 {+-} 4 C and heat of fusion between 140 and 213 kJ/kg. Experiments were conducted at three insolation intensities to evaluate the performance of each PCM in four different PV/PCM systems. The effect on thermal regulation of PV was determined by changing the (i) mass of PCM and (ii) thermal conductivities of the PCM and PV/PCM system. A maximum temperature reduction of 18 C was achieved for 30 min while 10 C temperature reduction was maintained for 5 h at -1000 W/m{sup 2} insolation. (author)

  13. Regulation of Emissions from Stationary Diesel Engines (released in AEO2007)

    Reports and Publications (EIA)

    2007-01-01

    On July 11, 2006, the Environmental Protection Agency (EPA) issued regulations covering emissions from stationary diesel engines New Source Performance Standards that limit emissions of NOx, particulate matter, SO2, carbon monoxide, and hydrocarbons to the same levels required for nonroad diesel engines. The regulation affects new, modified, and reconstructed diesel engines. Beginning with model year 2007, engine manufacturers must specify that new engines less than 3,000 horsepower meet the same emissions standard as nonroad diesel engines. For engines greater than 3,000 horsepower, the standard will be fully effective in 2011. Stationary diesel engine fuel will also be subject to the same standard as nonroad diesel engine fuel, which reduces the sulfur content of the fuel to 500 parts per million by mid-2007 and 15 parts per million by mid-2010.

  14. NNSA Updates Export Control Regulation | National Nuclear Security...

    National Nuclear Security Administration (NNSA)

    Part 810 into a regulation that both meets the requirement to ensure peaceful uses of nuclear power and the expanded use of nuclear technology worldwide. The updated rule is in...

  15. Title 14 CCR, Division 2, Chapter 4 - Development, Regulation...

    Open Energy Info (EERE)

    4 CCR, Division 2, Chapter 4 - Development, Regulation, and Conservation of Oil and Gas Resources Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  16. Oak Ridge EM Program Collaborates with Regulators on Groundwater Strategy

    Broader source: Energy.gov [DOE]

    OAK RIDGE, Tenn. – The Oak Ridge EM program has joined state and federal regulators in a series of workshops to address contaminated groundwater on the Oak Ridge Reservation.

  17. Groundwater Quantity Regulation in Vermont: A Path Forward |...

    Open Energy Info (EERE)

    Groundwater Quantity Regulation in Vermont: A Path Forward Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- Secondary Legal SourceSecondary Legal...

  18. Structural Insight into the Regulation of the SNARE Assembly...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insight into the Regulation of the SNARE Assembly by the Cell Polarity Protein Sro7 The cells that comprise many tissues are polarized, meaning that they have distinct 'sides' with...

  19. Y-12 and emerging environmental regulations in 1985

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    emerging environmental regulations in 1985 In Y-12's early days of its first mission, to separate Uranium 235 from natural uranium, the peak population hit 22,482 on August 21,...

  20. Issues in federal preemption of state appliance energy efficiency regulations

    SciTech Connect (OSTI)

    Fang, J.M.; Balistocky, S.; Schaefler, A.M.

    1982-12-01

    The findings and conclusions of the analysis of the various issues involved in the federal preemption of state regulations for the DOE no standard rule on covered appliances are summarized. The covered products are: refrigerators, refrigerator-freezers, freezers, clothes dryers, kitchen ranges and ovens, water heaters (excluding heat pump water heaters), room air conditioners, central air conditioners (excluding heat pumps), and furnaces. A detailed discussion of the rationale for the positions of groups offering comment for the record is presneted. The pertinent categories of state and local regulations and programs are explained, then detailed analysis is conducted on the covered products and regulations. Issues relating to the timing of preemption of state regulations are discussed, as well as issues relating to burden of proof, contents of petitions for exemptions from preemption, criteria for evaluating petitions, and procedural and other issues. (LEW)

  1. Rules and Regulations for the Management and Control of Designated...

    Open Energy Info (EERE)

    the Management and Control of Designated Ground Water Jump to: navigation, search OpenEI Reference LibraryAdd to library Reference: Rules and Regulations for the Management and...

  2. Cascaded'' pilot regulators help reduce LPG loss in hot weather

    SciTech Connect (OSTI)

    Not Available

    1994-08-08

    Fina Oil and Chemical Co. and Fisher Controls International used engineering resourcefulness to overcome heat-induced product loss from LPG storage bullets at Fina's Port Arthur, Tex., refinery. Fina had installed Fisher's Easy Joe 399A-6365, a pilot-operated, back-pressure-type regulator, on its LPG storage facility in 1991 as part of a fuel products modernization project. The regulators helped control the accumulation of noncondensible vapors, which collect in the storage bullets above the LPG. But summer heat extremes and surges in the tanks and lines made it possible for the operating pressure to increase so that the safety relief valve was activated before the pilot regulator was able to stabilize the pressure. The installation of pilot-type regulators, in cascaded, or series, formation, reduced product venting through relief valves.

  3. Code of Federal Regulations TRESPASSING ON DEPARTMENT OF ENERGY PROPERTY

    Broader source: Energy.gov [DOE]

    The regulations in this part are issued for the protection and security of facilities, installations and real property subject to the jurisdiction or administration, or in the custody of, the Department of Energy.

  4. Staff Listing - Office of Regulation and International Engagement...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Division of Natural Gas Regulation Larine Moore, Docket Room Manager Room 3E-042 Telephone (202) 586-9478 FAX (202) 586-6050 Natalie Wood, ADS Support Contractor Room 3E-042 ...

  5. Staff Listing - Office of Regulation and International Engagement...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DC 20585 Director of the Office of Regulation and International Engagement John A. Anderson, Director Room 3E-052 Telephone (202) 586-0521 FAX (202) 586-6050 Division of...

  6. Title 40 Code of Federal Regulations Chapter I, Subchapter C...

    Open Energy Info (EERE)

    Page Edit with form History Title 40 Code of Federal Regulations Chapter I, Subchapter C - Air Programs Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal...

  7. Volume regulation by human lymphocytes. Role of calcium

    SciTech Connect (OSTI)

    Grinstein, S.; Dupre, A.; Rothstein, A.

    1982-05-01

    Human peripheral blood lymphocytes regulate their volumes in hypotonic solutions. In hypotonic media in which Na+ is the predominant cation, an initial swelling phase is followed by a regulatory volume decrease (RVD) associated with a net loss of cellular K+. In media in which K+ is the predominant cation, the rapid initial swelling is followed by a slower second swelling phase. /sup 86/Rb+ fluxes increased during RVD and returned to normal when the original volume was approximately regained. Effects similar to those induced by hypotonic stress could also be produced by raising the intracellular Ca++ level. In isotonic, Ca++-containing media cells were found to shrink upon addition of the Ca++ ionophore A23187 in K+-free media, but to swell in K+-rich media. Exposure to Ca++ plus A23187 also increased /sup 86/Rb+ fluxes. Quinine (75 microM), an inhibitor of the Ca++-activated K+ pathway in other systems blocked RVD, the associated K+ loss, and the increase in /sup 86/Rb+ efflux. Quinine also inhibited the volume changes and the increased /sup 86/Rb fluxes induced by Ca++ plus ionophore. The calmodulin inhibitors trifluoperazine, pimozide and chlorpromazine blocked RVD as well as Ca++ plus A23187-induced volume changes. Trifluoperazine also prevented the increase in /sup 86/Rb+ fluxes and K+ loss induced by hypotonicity. Chlorpromazine sulfoxide, a relatively ineffective calmodulin antagonist, was considerably less potent as an inhibitor of RVD than chlorpromazine. It is suggested than an elevation in cytoplasmic (Ca++), triggered by cell swelling, increases the plasma membrane permeability to K+, the ensuing increased efflux of K+, associated anions, and osmotically obliged water, leading to cell shrinking (RVD).

  8. Implications of a stochastic approach to air-quality regulations

    SciTech Connect (OSTI)

    Witten, A.J.; Kornegay, F.C.; Hunsaker, D.B. Jr.; Long, E.C. Jr.; Sharp, R.D.; Walsh, P.J.; Zeighami, E.A.; Gordon, J.S.; Lin, W.L.

    1982-09-01

    This study explores the viability of a stochastic approach to air quality regulations. The stochastic approach considered here is one which incorporates the variability which exists in sulfur dioxide (SO/sub 2/) emissions from coal-fired power plants. Emission variability arises from a combination of many factors including variability in the composition of as-received coal such as sulfur content, moisture content, ash content, and heating value, as well as variability which is introduced in power plant operations. The stochastic approach as conceived in this study addresses variability by taking the SO/sub 2/ emission rate to be a random variable with specified statistics. Given the statistical description of the emission rate and known meteorological conditions, it is possible to predict the probability of a facility exceeding a specified emission limit or violating an established air quality standard. This study also investigates the implications of accounting for emissions variability by allowing compliance to be interpreted as an allowable probability of occurrence of given events. For example, compliance with an emission limit could be defined as the probability of exceeding a specified emission value, such as 1.2 lbs SO/sub 2//MMBtu, being less than 1%. In contrast, compliance is currently taken to mean that this limit shall never be exceeded, i.e., no exceedance probability is allowed. The focus of this study is on the economic benefits offered to facilities through the greater flexibility of the stochastic approach as compared with possible changes in air quality and health effects which could result.

  9. Compensated gain control circuit for buck regulator command charge circuit

    DOE Patents [OSTI]

    Barrett, D.M.

    1996-11-05

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit. 5 figs.

  10. Compensated gain control circuit for buck regulator command charge circuit

    DOE Patents [OSTI]

    Barrett, David M.

    1996-01-01

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit.

  11. Regulation Indentifier Number Title/Subject/Purpose Rule Type

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    as of 10/26/2015 Regulation Indentifier Number Title/Subject/Purpose Rule Type Status 1990-AA40 Adminstrative Requirements for Other Transactions: revise requirements for technology investment agreements to broaden to support all types of other transactions. NOPR Federal Register notice drafted and under review for significance determination per EO 12866 1991-AB73 Property Management Regulation: Update and eliminate inconsistencies and redundancies in DOE's personal property management

  12. Regulations.gov - Proposed Rule Document | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations.gov - Proposed Rule Document Regulations.gov - Proposed Rule Document In response to your phone call and e-mail below the proposed rule that you reference below regarding energy efficiency standards for manufactured housing has not been issued yet by the Department of Energy (DOE) and therefore we are still in the process of drafting a proposed rule and any necessary definitions. PDF icon Proposed Rule Email More Documents & Publications ISSUANCE 2015-02-04: Energy Conservation

  13. QB1 - Stochastic Gene Regulation (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Conference: QB1 - Stochastic Gene Regulation Citation Details In-Document Search Title: QB1 - Stochastic Gene Regulation Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present in the cell - Random motion and competition between reactants, Low copy, quantization of reactants, Upstream processes; (2) Fluctuations may be very important - Cell-to-cell variability, Cell fate decisions (switches), Signal amplification or damping, stochastic resonances; and (3) Some tools

  14. Method to determine transcriptional regulation pathways in organisms

    Office of Scientific and Technical Information (OSTI)

    (Patent) | SciTech Connect Method to determine transcriptional regulation pathways in organisms Citation Details In-Document Search Title: Method to determine transcriptional regulation pathways in organisms × You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and is provided as a public service. Visit OSTI to utilize additional information resources in energy science and

  15. Regulation Indentifier Number Title/Subject/Purpose Rule Type

    Energy Savers [EERE]

    as of 3/10/2016 The information contained herein is current as of its last update. Updates are only accomplished periodically for the entire list. For the official status of a specific rule, please see the Federal Register at https://www.regulations.gov/. Regulation Indentifier Number Title/Subject/Purpose Rule Type Status 1990-AA40 Adminstrative Requirements for Other Transactions: revise requirements for technology investment agreements to broaden to support all types of other transactions.

  16. New methods for tightly regulated gene expression and highly efficient

    Office of Scientific and Technical Information (OSTI)

    chromosomal integration of cloned genes for Methanosarcina species (Journal Article) | SciTech Connect New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species Citation Details In-Document Search Title: New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species A highly efficient method for chromosomal integration of cloned DNA into

  17. DOE's Program Regulating Liquefied Natural Gas Export Applications |

    Energy Savers [EERE]

    Department of Energy DOE's Program Regulating Liquefied Natural Gas Export Applications DOE's Program Regulating Liquefied Natural Gas Export Applications June 18, 2013 - 10:15am Addthis Statement of Christopher Smith, Acting Assistant Secretary for Fossil Energy before the House Committee on Energy and Commerce Subcommittees on Energy and Power. Thank you Chairman Whitfield, Ranking Member Rush, and members of the Subcommittee; I appreciate the opportunity to be here today to discuss the

  18. Acquisition Guide Chapter 1.1 - Acquisition Regulations System - (March

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2004) | Department of Energy Guide Chapter 1.1 - Acquisition Regulations System - (March 2004) Acquisition Guide Chapter 1.1 - Acquisition Regulations System - (March 2004) Guiding Principles * Authority is delegated to the maximum practical extent. * Reviews and approvals are minimized and the layering of review is avoided. * Participants in the acquisition process work together as a team and are empowered to make decisions in the areas of responsibility. PDF icon OPAM Policy Acquisition

  19. Ligand-specific regulation of the extracellular surface of a

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    G-protein-coupled receptor (Journal Article) | SciTech Connect Journal Article: Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor Citation Details In-Document Search Title: Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor G-protein-coupled receptors (GPCRs) are seven-transmembrane proteins that mediate most cellular responses to hormones and neurotransmitters. They are the largest group of therapeutic targets for a

  20. Comparing Emissions Benefits from Regulating Heavy Vehicle Idling |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Emissions Benefits from Regulating Heavy Vehicle Idling Comparing Emissions Benefits from Regulating Heavy Vehicle Idling 2005 Diesel Engine Emissions Reduction (DEER) Conference Presentations and Posters PDF icon 2005_deer_gaines.pdf More Documents & Publications Future Diesel Engine Thermal Efficiency Improvement andn Emissions Control Technology Oil Bypass Filter and Diesel Engine Idling Wear-Rate Evaluations Diesel Trucks - Then and Now

  1. Synthesis of segmented silica rods by growth temperature regulation

    Office of Scientific and Technical Information (OSTI)

    (Journal Article) | SciTech Connect segmented silica rods by growth temperature regulation Citation Details In-Document Search Title: Synthesis of segmented silica rods by growth temperature regulation Authors: Sharma, Jaswinder K [1] ; Datskos, Panos G [1] + Show Author Affiliations ORNL Publication Date: 2014-01-01 OSTI Identifier: 1115377 DOE Contract Number: DE-AC05-00OR22725 Resource Type: Journal Article Resource Relation: Journal Name: Angewandte Chemie International Edition; Journal

  2. California Regulations on Renewble Hydrogen and Low Carbon Technologies |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Regulations on Renewble Hydrogen and Low Carbon Technologies California Regulations on Renewble Hydrogen and Low Carbon Technologies Presentation at the Renewable Hydrogen Workshop, Nov. 16, 2009, in Palm Springs, CA PDF icon renewable_hydrogen_workshop_nov16_achtelik.pdf More Documents & Publications Transportation and Stationary Power Integration Workshop: A California Perspective Vision for Rollout of Fuel Cell Vehicles and Hydrogen Fuel Stations State of the

  3. SUMMARY OF REGULATIONS IMPLEMENTING FEDERAL POWER ACT SECTION 216 |

    Energy Savers [EERE]

    Department of Energy SUMMARY OF REGULATIONS IMPLEMENTING FEDERAL POWER ACT SECTION 216 SUMMARY OF REGULATIONS IMPLEMENTING FEDERAL POWER ACT SECTION 216 The Energy Policy Act of 2005 added section 216(h) to the Federal Power Act providing for the Department of Energy to act as the lead agency for coordinating all applicable Federal authorizations and related environmental reviews required under Federal law in order to site an electric transmission facility. The Act authorized DOE to issue

  4. Technical Demonstration of 2010 Emissions Regulations over Transient

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Operation | Department of Energy Demonstration of 2010 Emissions Regulations over Transient Operation Technical Demonstration of 2010 Emissions Regulations over Transient Operation Presentation given at DEER 2006, August 20-24, 2006, Detroit, Michigan. Sponsored by the U.S. DOE's EERE FreedomCar and Fuel Partnership and 21st Century Truck Programs. PDF icon 2006_deer_aneja.pdf More Documents & Publications Heavy-Duty Engine Technology for High Thermal Efficiency at EPA 2010 Emissions

  5. Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION

    Office of Environmental Management (EM)

    Subpart A - General Provisions | Department of Energy PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A - General Provisions Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A - General Provisions The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities. PDF icon Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION

  6. Collegiate Wind Competition Rules and Regulations | Department of Energy

    Office of Environmental Management (EM)

    Rules and Regulations Collegiate Wind Competition Rules and Regulations The competition challenges interdisciplinary teams of undergraduate students from a variety of academic programs to offer unique solutions to complex wind-energy-related problems. To fulfill the requirements, each team must perform the following multifaceted tasks: Develop and deliver a market-research-supported business plan that shapes the design and development of the team's turbine and load into a marketable wind power

  7. Department of Energy Acquisition Regulation (DEAR) Subpart 903.9:

    Office of Environmental Management (EM)

    Whistleblower Protections for Contractor Employees | Department of Energy Department of Energy Acquisition Regulation (DEAR) Subpart 903.9: Whistleblower Protections for Contractor Employees Department of Energy Acquisition Regulation (DEAR) Subpart 903.9: Whistleblower Protections for Contractor Employees Stakeholders: DOE Contractor employees Scope: This subpart of DEAR implements the DOE Contractor Employee Protection Program as set forth at 10 CFR part 708. This establishes the criteria

  8. Hazardous waste identification: A guide to changing regulations

    SciTech Connect (OSTI)

    Stults, R.G. )

    1993-03-01

    The Resource Conservation and Recovery Act (RCRA) was enacting in 1976 and amended in 1984 by the Hazardous and Solid Waste Amendments (HSWA). Since then, federal regulations have generated a profusion of terms to identify and describe hazardous wastes. Regulations that5 define and govern management of hazardous wastes are codified in Title 40 of the code of Federal Regulations, Protection of the environment''. Title 40 regulations are divided into chapters, subchapters and parts. To be defined as hazardous, a waste must satisfy the definition of solid waste any discharged material not specifically excluded from regulation or granted a regulatory variance by the EPA Administrator. Some wastes and other materials have been identified as non-hazardous and are listed in 40 CFR 261.4(a) and 261.4(b). Certain wastes that satisfy the definition of hazardous waste nevertheless are excluded from regulation as hazardous if they meet specific criteria. Definitions and criteria for their exclusion are found in 40 CFR 261.4(c)-(f) and 40 CFR 261.5.

  9. Rab proteins: The key regulators of intracellular vesicle transport

    SciTech Connect (OSTI)

    Bhuin, Tanmay; Roy, Jagat Kumar

    2014-10-15

    Vesicular/membrane trafficking essentially regulates the compartmentalization and abundance of proteins within the cells and contributes in many signalling pathways. This membrane transport in eukaryotic cells is a complex process regulated by a large and diverse array of proteins. A large group of monomeric small GTPases; the Rabs are essential components of this membrane trafficking route. Most of the Rabs are ubiquitously expressed proteins and have been implicated in vesicle formation, vesicle motility/delivery along cytoskeleton elements and docking/fusion at target membranes through the recruitment of effectors. Functional impairments of Rabs affecting transport pathways manifest different diseases. Rab functions are accompanied by cyclical activation and inactivation of GTP-bound and GDP-bound forms between the cytosol and membranes which is regulated by upstream regulators. Rab proteins are characterized by their distinct sub-cellular localization and regulate a wide variety of endocytic, transcytic and exocytic transport pathways. Mutations of Rabs affect cell growth, motility and other biological processes. - Highlights: Rab proteins regulate different signalling pathways. Deregulation of Rabs is the fundamental causes of a variety of human diseases. This paper gives potential directions in developing therapeutic targets. This paper also gives ample directions for modulating pathways central to normal physiology. These are the huge challenges for drug discovery and delivery in near future.

  10. Fact #771: March 18, 2013 California Zero-Emission Vehicle Mandate is Now in Effect

    Broader source: Energy.gov [DOE]

    A waiver granted by the Environmental Protection Agency (EPA) on December 27, 2012, allowed the Amendments to the California Zero Emission Vehicle (ZEV) Regulation to become effective immediately....

  11. H.A.R. 13-171 - Designation and Regulation of Water Management...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: H.A.R. 13-171 - Designation and Regulation of Water Management AreasLegal Published NA Year...

  12. WAC 332-17 Geothermal Drilling Rules and Regulations | Open Energy...

    Open Energy Info (EERE)

    17 Geothermal Drilling Rules and Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC 332-17 Geothermal Drilling...

  13. Colorado 4 CCR 723-3001, Definitions for Rules Regulating Electric...

    Open Energy Info (EERE)

    4 CCR 723-3001, Definitions for Rules Regulating Electric Utilities Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation:...

  14. 4 Code of Colorado Regulations (CCR) 723-3 | Open Energy Information

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 4 Code of Colorado Regulations (CCR) 723-3Legal Abstract Colorado Public Utilities...

  15. NMAC 1.2.2 Public Regulations Commission Rules of Procedure ...

    Open Energy Info (EERE)

    NMAC 1.2.2 Public Regulations Commission Rules of Procedure Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: NMAC 1.2.2...

  16. 1 NMAC 2.2 - Public Regulation Commission Rules of Procedure...

    Open Energy Info (EERE)

    NMAC 2.2 - Public Regulation Commission Rules of Procedure Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 1 NMAC 2.2 -...

  17. Code of Colorado Regulations 2 CCR 601-1, State Highway Access...

    Open Energy Info (EERE)

    Code of Colorado Regulations 2 CCR 601-1, State Highway Access Code Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Code of...

  18. Colorado Code of Regulations 2 CCR 601-18, State Utility Accommodation...

    Open Energy Info (EERE)

    Colorado Code of Regulations 2 CCR 601-18, State Utility Accommodation Code Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation:...

  19. O.A.R. 340-045 - Regulations Pertaining to NPDES and WPCF Permits...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: O.A.R. 340-045 - Regulations Pertaining to NPDES and WPCF PermitsLegal Abstract These...

  20. Voltage Regulation Using a Permanent Magnet Synchronous Generator with a Series Compensator: Preprint

    SciTech Connect (OSTI)

    Hsu, Ping; Wu, Ziping; Muljadi, Eduard; Gao, Wenzhong

    2015-08-24

    A wind power plant (WPP) is often operated at unity power factor, and the utility host where the WPP connects prefers to regulate the voltage. Although this may not be an issue in a stiff grid, the connection to a weak grid can be a problematic. This paper explores the advantages of having voltage regulation capability via reactive power control. Another issue in wind power generation is that not all turbines are able to control their reactive power due to technical reasons or contractual obligations. A synchronous condenser (SC) using a permanent magnet synchronous generator (PMSG) is proposed to provide necessary reactive power for regulating voltage at a weak grid connection. A PMSG has the advantage of higher efficiency and reliability. Because of its lack of a field winding, a PMSG is typically controlled by a full-power converter, which can be costly. In the proposed system, the reactive power of the SC is controlled by a serially connected compensator operating in a closed-loop configuration. The compensator also damps the PMSGs tendency to oscillate. The compensators VA rating is only a fraction of the rating of the SC and the PMSG. In this initial investigation, the proposed scheme is shown to be effective by computer simulations.

  1. Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells

    SciTech Connect (OSTI)

    Kucharzewska, Paulina; Welch, Johanna E.; Svensson, Katrin J.; Belting, Mattias

    2010-10-01

    The polyamines are essential for cancer cell proliferation during tumorigenesis. Targeted inhibition of ornithine decarboxylase (ODC), i.e. a key enzyme of polyamine biosynthesis, by {alpha}-difluoromethylornithine (DFMO) has shown anti-neoplastic activity in various experimental models. This activity has mainly been attributed to the anti-proliferative effect of DFMO in cancer cells. Here, we provide evidence that unperturbed ODC activity is a requirement for proper microvessel sprouting ex vivo as well as the migration of primary human endothelial cells. DFMO-mediated ODC inhibition was reversed by extracellular polyamine supplementation, showing that anti-angiogenic effects of DFMO were specifically related to polyamine levels. ODC inhibition was associated with an abnormal morphology of the actin cytoskeleton during cell spreading and migration. Moreover, our data suggest that de-regulated actin cytoskeleton dynamics in DFMO treated endothelial cells may be related to constitutive activation of the small GTPase CDC42, i.e. a well-known regulator of cell motility and actin cytoskeleton remodeling. These insights into the potential role of polyamines in angiogenesis should stimulate further studies testing the combined anti-tumor effect of polyamine inhibition and established anti-angiogenic therapies in vivo.

  2. The role of MAP4K3 in lifespan regulation of Caenorhabditiselegans

    SciTech Connect (OSTI)

    Khan, Maruf H.; Hart, Matthew J.; Rea, Shane L.

    2012-08-24

    Highlights: Black-Right-Pointing-Pointer Inhibition of MAP4K3 by RNAi leads to increased mean lifespan in Caenorhabditis elegans. Black-Right-Pointing-Pointer Mutation in the citron homology domain of MAP4K3 leads to increased mean lifespan. Black-Right-Pointing-Pointer Mutation in the kinase domain of MAP4K3 has no significant effect on mean lifespan. -- Abstract: The TOR pathway is a kinase signaling pathway that regulates cellular growth and proliferation in response to nutrients and growth factors. TOR signaling is also important in lifespan regulation - when this pathway is inhibited, either naturally, by genetic mutation, or by pharmacological means, lifespan is extended. MAP4K3 is a Ser/Thr kinase that has recently been found to be involved in TOR activation. Unexpectedly, the effect of this protein is not mediated via Rheb, the more widely known TOR activation pathway. Given the role of TOR in growth and lifespan control, we looked at how inhibiting MAP4K3 in Caenorhabditiselegans affects lifespan. We used both feeding RNAi and genetic mutants to look at the effect of MAP4K3 deficiency. Our results show a small but significant increase in mean lifespan in MAP4K3 deficient worms. MAP4K3 thus represents a new target in the TOR pathway that can be targeted for pharmacological intervention to control lifespan.

  3. Prediction of epigenetically regulated genes in breast cancer cell lines

    SciTech Connect (OSTI)

    Loss, Leandro A; Sadanandam, Anguraj; Durinck, Steffen; Nautiyal, Shivani; Flaucher, Diane; Carlton, Victoria EH; Moorhead, Martin; Lu, Yontao; Gray, Joe W; Faham, Malek; Spellman, Paul; Parvin, Bahram

    2010-05-04

    Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation of CpG islands may silence associated genes. Therefore, using high-throughput microarrays to measure CpG island methylation will lead to better understanding of tumor pathobiology and progression, while revealing potentially new biomarkers. We have examined a recently developed high-throughput technology for measuring genome-wide methylation patterns called mTACL. Here, we propose a computational pipeline for integrating gene expression and CpG island methylation profles to identify epigenetically regulated genes for a panel of 45 breast cancer cell lines, which is widely used in the Integrative Cancer Biology Program (ICBP). The pipeline (i) reduces the dimensionality of the methylation data, (ii) associates the reduced methylation data with gene expression data, and (iii) ranks methylation-expression associations according to their epigenetic regulation. Dimensionality reduction is performed in two steps: (i) methylation sites are grouped across the genome to identify regions of interest, and (ii) methylation profles are clustered within each region. Associations between the clustered methylation and the gene expression data sets generate candidate matches within a fxed neighborhood around each gene. Finally, the methylation-expression associations are ranked through a logistic regression, and their significance is quantified through permutation analysis. Our two-step dimensionality reduction compressed 90% of the original data, reducing 137,688 methylation sites to 14,505 clusters. Methylation-expression associations produced 18,312 correspondences, which were used to further analyze epigenetic regulation. Logistic regression was used to identify 58 genes from these correspondences that showed a statistically signifcant negative correlation between methylation profles and gene expression in the panel of breast cancer cell lines. Subnetwork enrichment of these genes has identifed 35 common regulators with 6 or more predicted markers. In addition to identifying epigenetically regulated genes, we show evidence of differentially expressed methylation patterns between the basal and luminal subtypes. Our results indicate that the proposed computational protocol is a viable platform for identifying epigenetically regulated genes. Our protocol has generated a list of predictors including COL1A2, TOP2A, TFF1, and VAV3, genes whose key roles in epigenetic regulation is documented in the literature. Subnetwork enrichment of these predicted markers further suggests that epigenetic regulation of individual genes occurs in a coordinated fashion and through common regulators.

  4. Permits and regulations applicable to United States ocean thermal energy conversion projects

    SciTech Connect (OSTI)

    Not Available

    1982-04-01

    This guide, covering permits and regulations applicable to U.S. OTEC projects, is another step in NOAA's process of providing the tools needed for OTEC project sponsors to design, develop, and implement commercial OTEC operations in the most efficient and cost-effective way. Its purpose is to provide OTEC project sponsors with an overview of potentially required licenses, permits, and authorizations, at both the Federal and State level, to give guidance on information about the proposed project needed to determine what permits are required, and to list, in a single reference, the agencies potentially involved in project review.

  5. Federal~Regulations, Titie.10 - Atomic Energy, Chapter 1; Part LOi- Control,

    Office of Legacy Management (LM)

    _. ., ATOMIC ENERGYCOMMISSION ' " ' Y>!. :' P&s&t td"ntiAtomic~Energy Act of 1951 and Section h0.21'of the Code of Federal~Regulations, Titie.10 - Atomic Energy, Chapter 1; Part LOi- Control, by;.the at$uic @ergy ,_. Conrmission,' wikhh the l+ts, o$ ,his, l*m~e.;o ' .. :, ,..: ,: .li ,..., .,:,:,. ,.- . . ..:.; .: r . . . Thli l&xns' e' is.kbject t0.si.l t&e provisiims of the &o&c &ergy Act' of.' 195k now dti.herbaft,er. lip effect 'and to all valid

  6. Environmental regulations and changes in petroleum refining operations

    SciTech Connect (OSTI)

    Lidderdale, T.C.M.

    1996-03-01

    The U.S. petroleum industry has responded to four major new federal rules on motor gasoline product quality in the last 6 years: Phase 1 Summer Volatility (Rvp) Regulation, June 1989; Phase 2 Summer Volatility (Rvp) regulation, May 1992; oxygenated Gasoline, November 1992; and reformulated Gasoline Phase I Simple Model, December 1994. These regulations have generated significant changes in domestic refinery operations, affecting marginal production costs and market prices, refinery yields, and the seasonality of production. Some changes have been dramatic. The price of motor gasoline has increased by as much as 60 {cents}/gal due to regulations. Refinery yields of motor gasoline (refinery output of motor gasoline as a fraction of refinery inputs or total refinery output), which historically peaked in the early summer to meet high summer driving demand, now are highest during the winter months. These changes in domestic refining operations are identified and related to the vapor pressure, oxygenated and reformulated gasoline (RFG) product quality regulations. This analysis uses linear regression equations from the Energy Information Administration`s (EIA) Short-Term Integrated Forecasting System (STIFS). The STIFS model is used for producing forecasts appearing in the EIA`s Short-Term Energy Outlook.

  7. Air-flow regulation system for a coal gasifier

    DOE Patents [OSTI]

    Fasching, George E. (Morgantown, WV)

    1984-01-01

    An improved air-flow regulator for a fixed-bed coal gasifier is provided which allows close air-flow regulation from a compressor source even though the pressure variations are too rapid for a single primary control loop to respond. The improved system includes a primary controller to control a valve in the main (large) air supply line to regulate large slow changes in flow. A secondary controller is used to control a smaller, faster acting valve in a secondary (small) air supply line parallel to the main line valve to regulate rapid cyclic deviations in air flow. A low-pass filter with a time constant of from 20 to 50 seconds couples the output of the secondary controller to the input of the primary controller so that the primary controller only responds to slow changes in the air-flow rate, the faster, cyclic deviations in flow rate sensed and corrected by the secondary controller loop do not reach the primary controller due to the high frequency rejection provided by the filter. This control arrangement provides at least a factor of 5 improvement in air-flow regulation for a coal gasifier in which air is supplied by a reciprocating compressor through a surge tank.

  8. Mutations in global regulators lead to metabolic selection during adaptation to complex environments

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Saxer, Gerda; Krepps, Michael D.; Merkley, Eric D.; Ansong, Charles; Deatherage Kaiser, Brooke L.; Valovska, Marie -Thérèse; Ristic, Nikola; Yeh, Ping T.; Prakash, Vittal P.; Leiser, Owen P.; et al

    2014-12-11

    Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Unlike adaptation to a single limiting resource, adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes since many mutations are required to achieve even modest gains in fitness. Since changing complex environments are quite common in nature, we investigated how such an epistatic bottleneck can be avoided to allow rapid adaptation. We show that adaptive mutations arise repeatedly in independently evolved populations in the context of greatly increased geneticmore » and phenotypic diversity. We go on to show that weak selection requiring substantial metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single-nucleotide variants of arcA and 18 mutations in rpoS, nine of which resulted in stop codons or large deletions, suggesting that a subtle modulation of ArcA function and knockouts of rpoS are largely responsible for the metabolic shifts leading to adaptation. These mutations allow a higher order “metabolic selection” that eliminates epistatic bottlenecks, which could occur when many changes would be required. Proteomic and carbohydrate analysis of adapting E. coli populations revealed an up-regulation of enzymes associated with the TCA cycle and amino acid metabolism and an increase in the secretion of putrescine. The overall effect of adaptation across populations is to redirect and efficiently utilize uptake and catabolism of abundant amino acids. Concomitantly, there is a pronounced spread of more ecologically limited strains that results from specialization through metabolic erosion. Remarkably, the global regulators arcA and rpoS can provide a “one-step” mechanism of adaptation to a novel environment, which highlights the importance of global resource management as a powerful strategy to adaptation.« less

  9. REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: ... Title: REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW ...

  10. Feedback regulated induction heater for a flowing fluid

    DOE Patents [OSTI]

    Migliori, Albert (Santa Fe, NM); Swift, Gregory W. (Los Alamos, NM)

    1985-01-01

    A regulated induction heater for heating a stream of flowing fluid to a predetermined desired temperature. The heater includes a radiofrequency induction coil which surrounds a glass tube through which the fluid flows. A heating element consisting of a bundle of approximately 200 stainless steel capillary tubes located within the glass tube couples the output of the induction coil to the fluid. The temperature of the fluid downstream from the heating element is sensed with a platinum resistance thermometer, the output of which is applied to an adjustable proportional and integral feedback control circuit which regulates the power applied to the induction coil. The heater regulates the fluid temperature to within 0.005.degree. C. at a flow rate of 50 cm.sup.3 /second with a response time of less than 0.1 second, and can accommodate changes in heat load up to 1500 watts.

  11. Feedback regulated induction heater for a flowing fluid

    DOE Patents [OSTI]

    Migliori, A.; Swift, G.W.

    1984-06-13

    A regulated induction heater for heating a stream of flowing fluid to a predetermined desired temperature. The heater includes a radiofrequency induction coil which surrounds a glass tube through which the fluid flows. A heating element consisting of a bundle of approximately 200 stainless steel capillary tubes located within the glass tube couples the output of the induction coil to the fluid. The temperature of the fluid downstream from the heating element is sensed with a platinum resistance thermometer, the output of which is applied to an adjustable porportional and integral feedback control circuit which regulates the power applied to the induction coil. The heater regulates the fluid temperature to within 0.005/sup 0/C at a flow rate of 50 cm/sup 3//sec with a response time of less than 0.1 second, and can accommodate changes in heat load up to 1500 watts.

  12. The effect of fluid flow on coiled tubing reach

    SciTech Connect (OSTI)

    Bhalla, K.; Walton, I.C.

    1996-12-31

    A critical parameter to the success of many coiled tubing (CT) operations in highly deviated or horizontal wells is the depth penetration that can be attained before the CT buckles and locks up. Achieving a desired depth is always critical in CT operations and attaining an additional reach of a few hundred feet can be crucial. This paper addresses the effect of fluid flow in the CT and in the CT/wellbore annulus on the state of force and stress in the CT, and thereby predicts its effect on the reach attainable by the CT. The flow of fluid through the CT and annulus between the CT and borehole modifies the pressures and the effective force which governs the mechanical stability of the CT. The net force per unit length due to fluid flow in the coiled tubing and annulus between the coiled tubing casing/well is calculated in terms of the shear stress and its effect on the onset of buckling and lockup is determined. The model is then implemented in a full tubing forces calculation and the effect of flowing fluids and producing fluids on reach is analyzed. The new model is utilized in the design of commercial jobs. The exact analytic model shows that fluid flow inside the CT has zero impact on reach, that downward flow in the annulus has a favourable impact, and upward flow in the annulus reduces the maximum attainable reach. Using the full tubing forces model, a coiled tubing job can be designed taking into account the flow of a fluid with a specified rheology, density and flow rate. Thus the feasibility of attaining a given reach can be more accurately determined. Results are presented in the form of the surface weight for commercial wells and compared to field jobs.

  13. MTBreg: The Database of Conditionally Regulated Proteins in Mycobacterium Tuberculosis

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kaufman, Markus; Pal, Debnath; Eisenberg, David

    Proteins up- and down- regulated in Mycobacterium tuberculosis grown under conditions mimicking infection are included in this database. It also includes information on proteins that are regulated by selected transcription factors or other regulatory proteins. The literature data provided here is complimentary to the databases provided by Michael Strong that include recent TB computational functional linkages and the Prolinks Database by Peter Bowers. The experimental condition, the experimental dataset and a literature reference will be displayed, including links to the computationally linked proteins in the Prolinks Database and the entry in the Mycobacterium tuberculosis Structural Genomics Database.[Copied from information at http://www.doe-mbi.ucla.edu/Services/MTBreg/

  14. Emission Regulations Reduced Impact of Climate Change in CA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Emission Regulations Reduced Impact of Climate Change in CA Emission Regulations Reduced Impact of Climate Change in CA Study shows clean diesel programs slashed black carbon, a powerful short-term contributor to global warming June 13, 2013 Jon Weiner 510-486-4014 jrweiner@lbl.gov CA-BC-graphic.jpg Sacramento - Reductions in emissions of black carbon since the late 1980s, mostly from diesel engines as a result of air quality programs, have resulted in a measurable reduction of concentrations of

  15. Will regulation impede the market for emissions allowances

    SciTech Connect (OSTI)

    Anderson, B.S.; Casey, W.T.

    1994-03-15

    Title IV of the Clean Air Act Amendments of 1990 allow for trading of allowances for SO[sub 2] emissions. For this process to be efficient and to achieve the goal of reducing emissions by 10 million tons from 1980 levels, a freely functioning market in allowance trading needs to exist. This market could be threatened by some state regulations that require utilities to obtain prior approval from state commissions before selling property. There are several solutions for state regulators to employ to avoid inadvertently interfering with the allowance trading market. This article describes some of those possible solutions.

  16. Multi-Pollutant Legislation and Regulations (released in AEO2005)

    Reports and Publications (EIA)

    2005-01-01

    The 108th Congress proposed and debated a variety of bills addressing pollution control at electric power plants but did not pass any of them into law. In addition, the Environmental Protection Agency (EPA) currently is preparing two regulations-a proposed Clean Air Interstate Rule (pCAIR) and a Clean Air Mercury Rule (CAMR)-to address emissions from coal-fired power plants. Several states also have taken legislative actions to limit pollutants from power plants in their jurisdictions. This section discusses three Congressional air pollution bills and the EPA's pCAIR and CAMR regulations.

  17. Method to determine transcriptional regulation pathways in organisms

    DOE Patents [OSTI]

    Gardner, Timothy S.; Collins, James J.; Hayete, Boris; Faith, Jeremiah

    2012-11-06

    The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.

  18. DOE - Office of Legacy Management -- Minneapolis-Honeywell Regulator Co -

    Office of Legacy Management (LM)

    PA 30 Minneapolis-Honeywell Regulator Co - PA 30 FUSRAP Considered Sites Site: MINNEAPOLIS-HONEYWELL REGULATOR CO (PA.30 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: Brown Instrument Division PA.30-1 Location: Wayne and Roberts Avenue , Philadelphia , Pennsylvania PA.30-2 Evaluation Year: 1987 PA.30-3 Site Operations: Research/Development and Testing - small-scale thermal conductivity test on uranium rods - early 1950s. PA.30-1 PA.30-2

  19. State Regulators Promote Consumer Choice in Retail Gas Markets

    Reports and Publications (EIA)

    1996-01-01

    Restructuring of interstate pipeline companies has created new choices and challenges for local distribution companies (LDCs), their regulators, and their customers. The process of separating interstate pipeline gas sales from transportation service has been completed and has resulted in greater gas procurement options for LDCs.

  20. Differences in the regulation of chemicals and radionuclides

    SciTech Connect (OSTI)

    Travis, C.C.

    1993-12-01

    Government regulations limiting public exposure to radionuclides and chemicals have historically been developed by regulatory agencies using different approaches with the result that levels of protection vary for the two classes of contaminants. These differences create difficulties in determining equitable regulatory measures when both radionuclides and chemical pollutants are involved. Generally, radiation exposure is not regulated as stringently as chemical exposure (Travis et al, 1989). The International commission on Radiological Protection (ICRP) recommends limiting excess environmental radiation exposure to the general public to 100 millirem per year (mrem/yr) (ICRP, 1991), a lifetime cancer risk of about 3.5E-3. An acceptable level of risk for chemical exposures is generally considered to be below 1E-6. Differences in regulatory approach for radionuclides and chemicals evoke debate over why they are different and which regulation strategy is better. Because these pollutants often coexist (mixed waste sites, contaminated metals and facilities, etc.), it is important to analyze inconsistencies in the regulation of chemicals and radionuclides and establish a more consistent approach to defining an acceptable level of exposure for these contaminants.

  1. Cell fate regulation governed by a repurposed bacterial histidine kinase

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy; Stock, Ann M.

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interactionmore » between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.« less

  2. Marine Hydrokinetic Energy Regulators Workshop: Lessons from Wind

    SciTech Connect (OSTI)

    Baring-Gould, E. Ian

    2015-09-03

    Ian Baring-Gould presented these lessons learned from wind energy to an audience of marine hydrokinetic regulators. Lessons learned spanned the areas of technology advances, using collaborative approaches to involve key stakeholders; using baseline studies to measure and prioritize wildlife impacts, and look at avoidance and mitigation options early in the process.

  3. OSHA safety regulation calls for step-by-step approach

    SciTech Connect (OSTI)

    Bellomo, P.J. (Arthur D. Little Inc., Houston, TX (US))

    1992-06-01

    The U.S. Occupational Safety and Health Administration's long-awaited process safety management (PSM) regulation mandates the implementation of a PSM program at facilities handling highly hazardous materials, including oil refineries and petrochemical plants. This article presents a step-by-step PSM program compliance strategy, delineated and explored through practical examples.

  4. Cell fate regulation governed by a repurposed bacterial histidine kinase

    SciTech Connect (OSTI)

    Childers, W. Seth [Stanford Univ. School of Medicine, Stanford, CA (United States); Xu, Qingping [SLAC National Accelerator Laboratory, Menlo Park, CA (United States); Mann, Thomas H. [Stanford Univ. School of Medicine, Stanford, CA (United States); Mathews, Irimpan I. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States); Blair, Jimmy A. [Stanford Univ. School of Medicine, Stanford, CA (United States); Deacon, Ashley M. [SLAC National Accelerator Laboratory, Menlo Park, CA (United States); Shapiro, Lucy [Stanford Univ. School of Medicine, Stanford, CA (United States); Stock, Ann M. [Rutgers Univ., New Brunswick, NJ (United States)

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.

  5. NNSA Updates Export Control Regulation | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration Updates Export Control Regulation | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Countering Nuclear Terrorism About Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Library Bios Congressional Testimony Fact Sheets Newsletters Press Releases Photo Gallery Jobs Apply for

  6. Photoreactive synthetic regulator of protein function and methods of use thereof

    DOE Patents [OSTI]

    Trauner, Dirk; Isacoff, Ehud Y; Kramer, Richard H; Banghart, Matthew R; Fortin, Doris L; Mourot, Alexandre

    2015-03-31

    The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

  7. 49 CFR Subchapter C, Parts 171-177: Hazardous Materials Regulations

    Broader source: Energy.gov [DOE]

    The U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration regulates the transport of hazardous materials through Title 49 of the Code of Federal Regulations (49 CFR), Subchapter C, "Hazardous Materials Regulations." Parts 171-177 provide general information on hazardous materials and regulation for their packaging and their shipment by rail, air, vessel, and public highway.

  8. Effects of temperature on serrated flows of Al0.5CoCrCuFeNi high-entropy alloy

    SciTech Connect (OSTI)

    Chen, Shuying; Xie, Xie; Chen, Bilin; Qiao, Junwei; Zhang, Yong; Ren, Yang; Dahmen, Karin A.; Liaw, Peter K.

    2015-08-14

    Compression behavior of the Al0.5CoCrCuFeNi high-entropy alloy (HEA) was studied at different temperatures from 673K to 873K at a low strain rate of 5 x 10-5/s to investigate the temperature effect on the mechanical properties and serration behavior. The face-centered cubic (FCC) structure is confirmed at the lower temperature of 673 K and 773 K, and a structure of mixed FCC and body-centered cubic (BCC) is identified at a higher temperature of 873 K after compression tests using high-energy synchrotron X-ray diffraction. As a result, by comparing the stress-strain curves at different temperatures, two opposite directions of serrations types were found, named upward serrations appearing at 673 K and 773 K and downward serrations at 873 K, which may be due to dynamic strain aging.

  9. Effects of temperature on serrated flows of Al0.5CoCrCuFeNi high-entropy alloy

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chen, Shuying; Xie, Xie; Chen, Bilin; Qiao, Junwei; Zhang, Yong; Ren, Yang; Dahmen, Karin A.; Liaw, Peter K.

    2015-08-14

    Compression behavior of the Al0.5CoCrCuFeNi high-entropy alloy (HEA) was studied at different temperatures from 673K to 873K at a low strain rate of 5 x 10-5/s to investigate the temperature effect on the mechanical properties and serration behavior. The face-centered cubic (FCC) structure is confirmed at the lower temperature of 673 K and 773 K, and a structure of mixed FCC and body-centered cubic (BCC) is identified at a higher temperature of 873 K after compression tests using high-energy synchrotron X-ray diffraction. As a result, by comparing the stress-strain curves at different temperatures, two opposite directions of serrations types weremore » found, named upward serrations appearing at 673 K and 773 K and downward serrations at 873 K, which may be due to dynamic strain aging.« less

  10. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Louisiana. Preliminary background report

    SciTech Connect (OSTI)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Louisiana Public Service Commission, composed of five members elected by the general electorate and elected for six-year terms. The Commission is charged with regulating all public utilities and has such other regulatory authority as provided by law. The Commission, however, has no power to regulate a public utility owned, operated, or regulated on the effective data of this constitution (1921) by the governing authority of one or more political subdivisions unless the Commission is authorized to regulate these utilities by the electorate of the political subdivision involved. An additional statutory provision excludes all municipally-owned public utilities from Commission regulation. New Orleans has retained the regulatory authority which it held as of the effective date of the Louisiana Constitution. Therefore, the Commission exercises no regulatory powers over investor or municipally-owned utilities in New Orleans. A municipality is empowered to own and operate a revenue-producing public utility within or without its boundaries and it may sell and distribute the commodity or service of the public utility within or without its corporate limits and may establish rates, rules, and regulations with respect to the sale and distribution. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  11. Simulating 3-D Radiative Transfer Effects over the Sierra Nevada Mountains using WRF

    SciTech Connect (OSTI)

    Gu, Yu; Liou, K. N.; Lee, W- L.; Leung, Lai-Yung R.

    2012-10-30

    A surface solar radiation parameterization based on deviations between 3-D and conventional plane-parallel radiative transfer models has been incorporated into the Weather Research and Forecasting (WRF) model to understand the solar insolation over mountain/snow areas and to investigate the impact of the spatial and temporal distribution and variation of surface solar fluxes on land-surface processes. Using the Sierra-Nevada in the western United States as a testbed, we show that mountain effect could produce up to ?50 to + 50Wm?2 deviations in the surface solar fluxes over the mountain areas, resulting in a temperature increase of up to 1 C on the sunny side. Upward surface sensible and latent heat fluxes are modulated accordingly to compensate for the change in surface solar fluxes. Snow water equivalent and surface albedo both show decreases on the sunny side of the mountains, indicating more snowmelt and hence reduced snow albedo associated with more solar insolation due to mountain effect. Soil moisture increases on the sunny side of the mountains due to enhanced snowmelt, while decreases on the shaded side. Substantial differences are found in the morning hours from 8-10 a.m. and in the afternoon around 3-5 p.m., while differences around noon and in the early morning and late afternoon are comparatively smaller. Variation in the surface energy balance can also affect atmospheric processes, such as cloud fields, through the modulation of vertical thermal structure. Negative changes of up to ?40 gm?2 are found in the cloud water path, associated with reductions in the surface insolation over the cloud region. The day-averaged deviations in the surface solar flux are positive over the mountain areas and negative in the valleys, with a range between ?12~12Wm?2. Changes in sensible and latent heat fluxes and surface skin temperature follow the solar insolation pattern. Differences in the domain-averaged diurnal variation over the Sierras show that the mountain area receives more solar insolation during early morning and late afternoon, resulting in enhanced upward sensible heat and latent heat fluxes from the surface and a corresponding increase in surface skin temperature. During the middle of the day, however, the surface insolation and heat fluxes show negative changes, indicating a cooling effect. Hence overall, the diurnal variations of surface temperature and surface fluxes in the Sierra-Nevada are reduced through the interactions of radiative transfer and mountains. The hourly differences of the surface solar insolation in higher elevated regions, however, show smaller magnitude in negative changes during the middle of the day and possibly more solar fluxes received during the whole day.

  12. Legal nature of LPG (liquefied petroleum gas) regulation

    SciTech Connect (OSTI)

    Liddell, G.

    1986-08-01

    The commercial exploitation of Liquefied Petroleum Gas (LPG) in New Zealand has occurred without a particular and comprehensive concern for any legal implications. The paper in Part I examines definitional questions, assesses in Part II the ability of courts and quasi-courts to evaluate risks associated with the product, examines in Part III the utility of common law remedies for injuries or associated with or arising from LPG, analyzes in Part IV the statutory regulation of LPG, concentrating particularly on the Dangerous Goods (Class 2 - Gases) Regulations 1980, discusses in Part V recent planning case-law concerning LPG development, and concludes that some reform is necessary to produce a more-coherent and precise regulatory regime that takes into account both the needs of developers and those affected by the development of LPG.

  13. Environmental assessment for the satellite power system concept development and evaluation program: atmospheric effects

    SciTech Connect (OSTI)

    Rote, D.M.; Brubaker, K.L.; Lee, J.L.

    1980-11-01

    The US Department of Energy (DOE) has undertaken a preliminary, three-year program to investigate the impacts of the construction and operation of a satellite power system, of unprecedented scale. The Department of Energy's program, titled The Concept Development and Evaluation Program, focused its investigations on a Reference System description that calls for the use of either silicon (Si) or gallium aluminum-arsenide (GaAlAs) photovoltaic cells on 60 satellites to be constructed in GEO over a 30-yr period. Rectennas would be constructed on the ground to receive microwave energy from the satellites. Each satellite-rectenna pair is designed to produce 5 GW of power on an essentially continuous basis for use as a baseload power source for an electric power distribution system. The environmental assessment part of the program was divided into five interdependent task areas. The present document constitutes the final technical report on one of the five task areas, the Assessment of the Atmospheric Effects, and as such presents an in-depth summary of work performed during the assessment program. The issues associated with SPS activities in the troposphere are examined. These include tropospheric weather modification related to rectenna operations and rocket launches, and air quality impacts related to rocketlaunch ground clouds. Then progressing upward through the various levels of the atmosphere, the principal middle and upper atmospheric effects associated with rocket effluents are analyzed. Finally, all of the potential SPS atmospheric effects are summarized.

  14. Application of EPA regulations to low-level radioactive waste

    SciTech Connect (OSTI)

    Bowerman, B.S.; Piciulo, P.L.

    1985-01-01

    The survey reported here was conducted with the intent of identifying categories of low-level radioactive wastes which would be classified under EPA regulations 40 CFR Part 261 as hazardous due to the chemical properties of the waste. Three waste types are identified under these criteria as potential radioactive mixed wastes: wastes containing organic liquids; wastes containing lead metal; and wastes containing chromium. The survey also indicated that certain wastes, specific to particular generators, may also be radioactive mixed wastes. Ultimately, the responsibility for determining whether a facility's wastes are mixed wastes rest with the generator. However, the uncertainties as to which regulations are applicable, and the fact that no legal definition of mixed wastes exists, make such a determination difficult. In addition to identifying mixed wastes, appropriate methods for the management of mixed wastes must be defined. In an ongoing study, BNL is evaluating options for the management of mixed wastes. These options will include segregation, substitution, and treatments to reduce or eliminate chemical hazards associated with the wastes listed above. The impacts of the EPA regulations governing hazardous wastes on radioactive mixed waste cannot be assessed in detail until the applicability of these regulations is agreed upon. This issue is still being discussed by EPA and NRC and should be resolved in the near future. Areas of waste management which may affect generators of mixed wastes include: monitoring/tracking of wastes before shipment; chemical testing of wastes; permits for treatment of storage of wastes; and additional packaging requirements. 3 refs., 1 fig., 2 tabs.

  15. Self-Regulating, Nonflamable Rechargeable Lithium Batteries - Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Innovation Portal Self-Regulating, Nonflamable Rechargeable Lithium Batteries Lawrence Berkeley National Laboratory Contact LBL About This Technology Technology Marketing SummaryRechargeable lithium batteries are superior to other rechargeable batteries due to their ability to store more energy per unit size and weight and to operate at higher voltages. The performance of lithium ion batteries available today, however, has been compromised by their tendency to overheat during operation. This

  16. Regulators caught in fierce crossfire on new generation

    SciTech Connect (OSTI)

    2008-07-15

    Efforts of several utilities to construct new power plants not based on conventional coal but rather coal-gasification technology or nuclear fission are described. Several have been canceled because of rising costs. State regulators are faced with trying to protect customers from high rates and unsound investments by utilities. Critics maintain that ratepayers should not be forced to pay higher rates for plants that may never be built.

  17. Enforcement Regulations and Directives - Security | Department of Energy

    Energy Savers [EERE]

    Security Enforcement Regulations and Directives - Security Classified Information Security 10 C.F.R Part 824 - Procedural Rules for the Assessment of Civil Penalties for Classified Information Security Violations 10 C.F.R Part 1016 - Safeguarding of Restricted Data 10 C.F.R Part 1045 - Nuclear Classification and Declassification DOE Directives and NNSA Policy Letters Enforceable under 10 C.F.R. Part 824

  18. DOE's Program Regulating Liquefied Natural Gas Export Applications |

    Energy Savers [EERE]

    Department of Energy 19, 2013 - 2:52pm Addthis Statement of Christopher Smith, Acting Assistant Secretary for Fossil Energy before the House Committee on Oversight and Government Reform, Subcommittee on Energy Policy, Health Care, and Entitlements View the archived Congressional Hearing on YouTube Thank you Chairman Lankford, Ranking Member Speier, and members of the Committee; I appreciate the opportunity to be here today to discuss the Department of Energy's (DOE) program regulating the

  19. Carbon or Graphite Foam Heating Element for Regulating Engine Fluids -

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Innovation Portal Advanced Materials Advanced Materials Find More Like This Return to Search Carbon or Graphite Foam Heating Element for Regulating Engine Fluids Oak Ridge National Laboratory Contact ORNL About This Technology Technology Marketing SummaryAutomotive engines need to run hotter to meet requirements for better fuel economy and lower emissions, but devices to keep engine fluids from becoming too hot can add weight, cost, and complexity to engine designs. ORNL researchers

  20. NREL: Technology Deployment - Fleets Regulated by the Energy Policy Act

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fleets Regulated by the Energy Policy Act NREL supports the U.S. Department of Energy's (DOE) regulatory activities involving requirements under the Energy Policy Act (EPAct) for federal, state, and alternative fuel provider fleets. Congress passed EPAct in 1992 to reduce U.S. petroleum consumption through the use of alternative fuels, alternative fuel vehicles (AFVs), and other petroleum-displacement methods. DOE's primary means of achieving this goal in the transportation sector has been to

  1. Environmental regulation of coal mining. SMCRA`s Second Decade

    SciTech Connect (OSTI)

    McElfish, J.M.; Beier, A.E.

    1990-12-31

    If you find yourself involved in the workings of the Surface Mining Control and Reclamation Act of 1977 (SMCRA), let ELI`s guide take you through SMCRA`s second decade. Environmental Regulation of Coal mining: SMCRA`s Second Decade gives you a clear picture of SMCRA`s statutory and regulatory requirements, and identifies the key policy disputes and problems that will be confronted in the years ahead.

  2. Code of Federal Regulations Nuclear Activities | Department of Energy

    Office of Environmental Management (EM)

    Nuclear Activities Code of Federal Regulations Nuclear Activities April 24,2010 This part sets forth the procedures to govern the conduct of persons involved in DOE nuclear activities and, in particular, to achieve compliance with the DOE Nuclear Safety Requirements by all persons subject to those requirements. 10 C.F.R. 820, Procedural Rules for DOE Nuclear Activities, sets forth the procedures to implement the provisions of the Price-Anderson Amendments Act of 1988 (PAAA), which subjects DOE

  3. Appendix A - CEQ Regulations © Environmental Planning Strategies, Inc.

    National Nuclear Security Administration (NNSA)

    A - CEQ Regulations © Environmental Planning Strategies, Inc. 51 Appendix A 40 CFR 1500-1508-- Council On Environmental Quality 40 CFR PART 1500--PURPOSE, POLICY, AND MANDATE §1500.1 Purpose. (a) The National Environmental Policy Act (NEPA) is our basic national charter for protection of the environment. It establishes policy, sets goals (section 101), and provides means (section 102) for carrying out the policy. Section 102(2) contains "action-forcing" provisions to make sure that

  4. DC switching regulated power supply for driving an inductive load

    DOE Patents [OSTI]

    Dyer, George R. (Norris, TN)

    1986-01-01

    A power supply for driving an inductive load current from a dc power supply hrough a regulator circuit including a bridge arrangement of diodes and switching transistors controlled by a servo controller which regulates switching in response to the load current to maintain a selected load current. First and second opposite legs of the bridge are formed by first and second parallel-connected transistor arrays, respectively, while the third and fourth legs of the bridge are formed by appropriately connected first and second parallel connected diode arrays, respectively. The regulator may be operated in three "stages" or modes: (1) For current runup in the load, both first and second transistor switch arrays are turned "on" and current is supplied to the load through both transistor arrays. (2) When load current reaches the desired level, the first switch is turned "off", and load current "flywheels" through the second switch array and the fourth leg diode array connecting the second switch array in series with the load. Current is maintained by alternating between modes 1 and 2 at a suitable duty cycle and switching rate set by the controller. (3) Rapid current rundown is accomplished by turning both switch arrays "off", allowing load current to be dumped back into the source through the third and fourth diode arrays connecting the source in series opposition with the load to recover energy from the inductive load. The three operating states are controlled automatically by the controller.

  5. DC switching regulated power supply for driving an inductive load

    DOE Patents [OSTI]

    Dyer, G.R.

    1983-11-29

    A dc switching regulated power supply for driving an inductive load is provided. The regulator basic circuit is a bridge arrangement of diodes and transistors. First and second opposite legs of the bridge are formed by first and second parallel-connected transistor arrays, respectively, while the third and fourth legs of the bridge are formed by appropriately connected first and second parallel connected diode arrays, respectively. A dc power supply is connected to the input of the bridge and the output is connected to the load. A servo controller is provided to control the switching rate of the transistors to maintain a desired current to the load. The regulator may be operated in three stages or modes: (1) for current runup in the load, both first and second transistor switch arrays are turned on and current is supplied to the load through both transistor arrays. (2) When load current reaches the desired level, the first switch is turned off, and load current flywheels through the second switch array and the fourth leg diode array connecting the second switch array in series with the load. Current is maintained by alternating between modes 1 and 2 at a suitable duty cycle and switching rate set by the controller. (3) Rapid current rundown is accomplished by turning both switch arrays off, allowing load current to be dumped back into the source through the third and fourth diode arrays connecting the source in series opposition with the load to recover energy from the inductive load.

  6. Final Report for Regulation of Embryonic Development in Higher Plants

    SciTech Connect (OSTI)

    Harada, John J.

    2013-10-22

    The overall goal of the project was to define the cellular processes that underlie embryo development in plants at a mechanistic level. Our studies focused on a critical transcriptional regulator, Arabidopsis LEAFY COTYLEDON (LEC1), that is necessary and sufficient to induce processes required for embryo development. Because LEC1 regulates lipid accumulation during the maturation phase of embryo development, information about LEC1 may be useful in designing approaches to enhance biofuel production in plants. During the tenure of this project, we determined the molecular mechanisms by which LEC1 acts as a transcription factor in embryos. We also identified genes directly regulated by LEC1 and showed that many of these genes are involved in maturation processes. This information has been useful in dissecting the gene regulatory networks controlling embryo development. Finally, LEC1 is a novel isoform of a transcription factor that is conserved among eukaryotes, and LEC1 is active primarily in seeds. Therefore, we determined that the LEC1-type transcription factors first appeared in lycophytes during land plant evolution. Together, this study provides basic information that has implications for biofuel production.

  7. Comparative genomics of transcriptional regulation of methionine metabolism in proteobacteria

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Leyn, Semen A.; Suvorova, Inna A.; Kholina, Tatiana D.; Sherstneva, Sofia S.; Novichkov, Pavel S.; Gelfand, Mikhail S.; Rodionov, Dmitry A.; Kuipers, Oscar P.

    2014-11-20

    Methionine metabolism and uptake genes in Proteobacteria are controlled by a variety of RNA and DNA regulatory systems. We have applied comparative genomics to reconstruct regulons for three known transcription factors, MetJ, MetR, and SahR, and three known riboswitch motifs, SAH, SAM-SAH, and SAM_alpha, in ~200 genomes from 22 taxonomic groups of Proteobacteria. We also identified two novel regulons: a SahR-like transcription factor SamR controlling various methionine biosynthesis genes in the Xanthomonadales group, and a potential RNA regulatory element with terminator-antiterminator mechanism controlling the metX or metZ genes in beta-proteobacteria. For each analyzed regulator we identified the core, taxon-specific andmore » genome-specific regulon members. By analyzing the distribution of these regulators in bacterial genomes and by comparing their regulon contents we elucidated possible evolutionary scenarios for the regulation of the methionine metabolism genes in Proteobacteria.« less

  8. Comparative genomics of transcriptional regulation of methionine metabolism in proteobacteria

    SciTech Connect (OSTI)

    Leyn, Semen A.; Suvorova, Inna A.; Kholina, Tatiana D.; Sherstneva, Sofia S.; Novichkov, Pavel S.; Gelfand, Mikhail S.; Rodionov, Dmitry A.; Kuipers, Oscar P.

    2014-11-20

    Methionine metabolism and uptake genes in Proteobacteria are controlled by a variety of RNA and DNA regulatory systems. We have applied comparative genomics to reconstruct regulons for three known transcription factors, MetJ, MetR, and SahR, and three known riboswitch motifs, SAH, SAM-SAH, and SAM_alpha, in ~200 genomes from 22 taxonomic groups of Proteobacteria. We also identified two novel regulons: a SahR-like transcription factor SamR controlling various methionine biosynthesis genes in the Xanthomonadales group, and a potential RNA regulatory element with terminator-antiterminator mechanism controlling the metX or metZ genes in beta-proteobacteria. For each analyzed regulator we identified the core, taxon-specific and genome-specific regulon members. By analyzing the distribution of these regulators in bacterial genomes and by comparing their regulon contents we elucidated possible evolutionary scenarios for the regulation of the methionine metabolism genes in Proteobacteria.

  9. Physiology and Regulation of Calcium Channels in Stomatal Guard Cells

    SciTech Connect (OSTI)

    Schroeder, Julian I.

    2007-05-02

    Stomatal pores in the epidermis of leaves regulate the diffusion of CO2 into leaves for photosynthetic carbon fixation and control water loss of plants during drought periods. Guard cells sense CO2, water status, light and other environmental conditions to regulate stomatal apertures for optimization of CO2 intake and plant growth under drought stress. The cytosolic second messenger calcium contributes to stomatal movements by transducing signals and regulating ion channels in guard cells. Studies suggest that both plasma membrane Ca2+ influx channels and vacuolar/organellar Ca2+ release channels contribute to ABA-induced Ca2+ elevations in guard cells. Recent research in the P.I.'s laboratory has led to identification of a novel major cation-selective Ca2+-permeable influx channel (Ica) in the plasma membrane of Arabidopsis guard cells. These advances will allow detailed characterization of Ica plasma membrane Ca2+ influx channels in guard cells. The long term goal of this research project is to gain a first detailed characterization of these novel plasma membrane Ca2+-permeable channel currents in Arabidopsis guard cells. The proposed research will investigate the hypothesis that Ica represents an important Ca2+ influx pathway for ABA and CO2 signal transduction in Arabidopsis guard cells. These studies will lead to elucidation of key signal transduction mechanisms by which plants balance CO2 influx into leaves and transpirational water loss and may contribute to future strategies for manipulating gas exchange for improved growth of crop plants and for biomass production.

  10. DOE Ex Parte Memorandum - Center for Regulatory Effectiveness | Department

    Energy Savers [EERE]

    of Energy Memorandum - Center for Regulatory Effectiveness DOE Ex Parte Memorandum - Center for Regulatory Effectiveness The Center for Regulatory Effectiveness (CRE) is submitting this memorandum pursuant to the Department of Energy's (DOE) Guidance on Ex Parte Communications. PDF icon Center_for_Reg_Effectiveness.pdf More Documents & Publications DOE Review of Regulations - Center for Regulatory Effectiveness Comments Regulatory Burden RFI: Revitalization of DOE's Role as a Regulatory

  11. Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σE-regulated SPI-2 gene expression

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Jie; Overall, Christopher C.; Nakayasu, Ernesto S.; Kidwai, Afshan S.; Jones, Marcus B.; Johnson, Rudd; Nguyen, Nhu T.; McDermott, Jason E.; Ansong, Charles; Heffron, Fred; et al

    2015-02-10

    The extracytoplasmic functioning sigma factor ?E is known to play an essential role for Salmonella enterica serovar Typhimurium to survive and proliferate in macrophages and mice. However, its regulatory network is not well characterized, especially during infection. Here we used microarray to identify genes regulated by ?E in Salmonella grown in three conditions: a nutrient-rich condition and two others that mimic early and late intracellular infection. We found that in each condition ?E regulated different sets of genes, and notably, several global regulators. When comparing nutrient-rich and infection-like conditions, large changes were observed in the expression of genes involved inmoreSalmonella pathogenesis island (SPI)-1 type-three secretion system (TTSS), SPI-2 TTSS, protein synthesis, and stress responses. In total, the expression of 58% of Salmonella genes was affected by ?E in at least one of the three conditions. An important finding is that ?E up-regulates SPI-2 genes, which are essential for Salmonella intracellular survival, by up-regulating SPI-2 activator ssrB expression at the early stage of infection and down-regulating SPI-2 repressor hns expression at a later stage. Moreover, ?E is capable of countering the silencing of H-NS, releasing the expression of SPI-2 genes. This connection between ?E and SPI-2 genes, combined with the global regulatory effect of ?E, may account for the lethality of rpoE-deficient Salmonella in murine infection.less

  12. Processes regulating progressive nitrogen limitation under elevated carbon dioxide: a meta-analysis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Liang, J.; Qi, X.; Souza, L.; Luo, Y.

    2015-10-20

    Nitrogen (N) cycle has the potential to regulate climate change through its influence on carbon (C) sequestration. Although extensive researches have been done to explore whether or not progressive N limitation (PNL) occurs under CO2 enrichment, a comprehensive assessment of the processes that regulate PNL is still lacking. Here, we quantitatively synthesized the responses of all major processes and pools in terrestrial N cycle with meta-analysis of CO2 experimental data available in the literature. The results showed that CO2 enrichment significantly increased N sequestration in plant and litter pools but not in soil pool. Thus, the basis of PNL occurrencemorepartially exists. However, CO2 enrichment also significantly increased the N influx via biological N fixation, but decreased the N efflux via leaching. In addition, no general diminished CO2 fertilization effect on plant growth over time was observed. Overall, our analyses suggest that the extra N supply by the increased biological N fixation and decreased leaching may potentially alleviate PNL under elevated CO2 conditions. Moreover, our synthesis showed that CO2 enrichment increased soil ammonium (NH4+) but decreased nitrate (NO3-). The different responses of NH4+ and NO3-, and the consequent biological processes, may result in changes in soil microenvironment, community structures and above-belowground interactions, which could potentially affect the terrestrial biogeochemical cycles and the feedback to climate change.less

  13. Defining the role of mesenchymal stromal cells on the regulation of matrix metalloproteinases in skeletal muscle cells

    SciTech Connect (OSTI)

    Sassoli, Chiara; Nosi, Daniele; Tani, Alessia; Chellini, Flaminia; Mazzanti, Benedetta; Quercioli, Franco; Zecchi-Orlandini, Sandra; Formigli, Lucia

    2014-05-01

    Recent studies indicate that mesenchymal stromal cell (MSC) transplantation improves healing of injured and diseased skeletal muscle, although the mechanisms of benefit are poorly understood. In the present study, we investigated whether MSCs and/or their trophic factors were able to regulate matrix metalloproteinase (MMP) expression and activity in different cells of the muscle tissue. MSCs in co-culture with C2C12 cells or their conditioned medium (MSC-CM) up-regulated MMP-2 and MMP-9 expression and function in the myoblastic cells; these effects were concomitant with the down-regulation of the tissue inhibitor of metalloproteinases (TIMP)-1 and -2 and with increased cell motility. In the single muscle fiber experiments, MSC-CM administration increased MMP-2/9 expression in Pax-7{sup +} satellite cells and stimulated their mobilization, differentiation and fusion. The anti-fibrotic properties of MSC-CM involved also the regulation of MMPs by skeletal fibroblasts and the inhibition of their differentiation into myofibroblasts. The treatment with SB-3CT, a potent MMP inhibitor, prevented in these cells, the decrease of ?-smooth actin and type-I collagen expression induced by MSC-CM, suggesting that MSC-CM could attenuate the fibrogenic response through mechanisms mediated by MMPs. Our results indicate that growth factors and cytokines released by these cells may modulate the fibrotic response and improve the endogenous mechanisms of muscle repair/regeneration. - Highlights: MSC-CM contains paracrine factors that up-regulate MMP expression and function in different skeletal muscle cells. MSC-CM promotes myoblast and satellite cell migration, proliferation and differentiation. MSC-CM negatively interferes with fibroblast-myoblast transition in primary skeletal fibroblasts. Paracrine factors from MSCs modulate the fibrotic response and improve the endogenous mechanisms of muscle regeneration.

  14. Structure-based functional characterization of Repressor of Toxin (Rot), a central regulator of Staphylococcus aureus virulence

    SciTech Connect (OSTI)

    Killikelly, April [New York Univ. School of Medicine, NY (United States). Dept. of Biochemistry and Molecular Pharmacology; Jakoncic, Jean [Brookhaven National Laboratory (BNL), Upton, NY (United States). Photon Sciences Directorate; Benson, Meredith A. [New York Univ. School of Medicine, NY (United States). Dept. of Microbiology; Ohneck, Elizabeth A. [New York Univ. School of Medicine, NY (United States). Dept. of Microbiology; Sampson, Jared M. [New York Univ. School of Medicine, NY (United States). Dept. of Biochemistry and Molecular Pharmacology; Spurrier, Brett [New York Univ. School of Medicine, NY (United States). Dept. of Biochemistry and Molecular Pharmacology; Torres, Victoer J. [New York Univ. School of Medicine, NY (United States). Dept. of Microbiology; Kong, Xian-Peng [New York Univ. School of Medicine, NY (United States). Dept. of Biochemistry and Molecular Pharmacology

    2014-10-20

    Staphylococcus aureus is responsible for a large number of diverse infections worldwide. In order to support its pathogenic lifestyle, S. aureus has to regulate the expression of virulence factors in a coordinated fashion. One of the central regulators of the S. aureus virulence regulatory networks is the transcription factor repressor of toxin (Rot). Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors. However, the mechanism by which Rot mediates gene regulation has remained elusive. Here, we have determined the crystal structure of Rot and used this information to probe the contribution made by specific residues to Rot function. Rot was found to form a dimer, with each monomer harboring a winged helix-turn-helix (WHTH) DNA-binding motif. Despite an overall acidic pI, the asymmetric electrostatic charge profile suggests that Rot can orient the WHTH domain to bind DNA. Structure-based site-directed mutagenesis studies demonstrated that R91, at the tip of the wing, plays an important role in DNA binding, likely through interaction with the minor groove. We also found that Y66, predicted to bind within the major groove, contributes to Rot interaction with target promoters. Evaluation of Rot binding to different activated and repressed promoters revealed that certain mutations on Rot exhibit promoter-specific effects, suggesting for the first time that Rot differentially interacts with target promoters. This work provides insight into a precise mechanism by which Rot controls virulence factor regulation in S. aureus.

  15. Structure-based functional characterization of repressor of toxin (Rot), a central regulator of staphylococcus aureus virulence

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Killikelly, April; Jakoncic, Jean; Benson, Meredith A.; Ohneck, Elizabeth A.; Sampson, Jared M.; Spurrier, Brett; Torres, Victoer J.; Kong, Xian -Peng

    2014-10-20

    Staphylococcus aureus is responsible for a large number of diverse infections worldwide. In order to support its pathogenic lifestyle, S. aureus has to regulate the expression of virulence factors in a coordinated fashion. One of the central regulators of the S. aureus virulence regulatory networks is the transcription factor repressor of toxin (Rot). Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors. However, the mechanism by which Rot mediates gene regulation has remained elusive. Here, we have determined the crystal structure ofmore » Rot and used this information to probe the contribution made by specific residues to Rot function. Rot was found to form a dimer, with each monomer harboring a winged helix-turn-helix (WHTH) DNA-binding motif. Despite an overall acidic pI, the asymmetric electrostatic charge profile suggests that Rot can orient the WHTH domain to bind DNA. Structure-based site-directed mutagenesis studies demonstrated that R91, at the tip of the wing, plays an important role in DNA binding, likely through interaction with the minor groove. We also found that Y66, predicted to bind within the major groove, contributes to Rot interaction with target promoters. Evaluation of Rot binding to different activated and repressed promoters revealed that certain mutations on Rot exhibit promoter-specific effects, suggesting for the first time that Rot differentially interacts with target promoters. As a result, this work provides insight into a precise mechanism by which Rot controls virulence factor regulation in S. aureus.« less

  16. Mutations in global regulators lead to metabolic selection during adaptation to complex environments

    SciTech Connect (OSTI)

    Saxer, Gerda; Krepps, Michael D.; Merkley, Eric D.; Ansong, Charles; Deatherage Kaiser, Brooke L.; Valovska, Marie -Thrse; Ristic, Nikola; Yeh, Ping T.; Prakash, Vittal P.; Leiser, Owen P.; Nakhleh, Luay; Gibbons, Henry S.; Kreuzer, Helen W.; Shamoo, Yousif; Matic, Ivan

    2014-12-11

    Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Unlike adaptation to a single limiting resource, adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes since many mutations are required to achieve even modest gains in fitness. Since changing complex environments are quite common in nature, we investigated how such an epistatic bottleneck can be avoided to allow rapid adaptation. We show that adaptive mutations arise repeatedly in independently evolved populations in the context of greatly increased genetic and phenotypic diversity. We go on to show that weak selection requiring substantial metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single-nucleotide variants of arcA and 18 mutations in rpoS, nine of which resulted in stop codons or large deletions, suggesting that a subtle modulation of ArcA function and knockouts of rpoS are largely responsible for the metabolic shifts leading to adaptation. These mutations allow a higher order metabolic selection that eliminates epistatic bottlenecks, which could occur when many changes would be required. Proteomic and carbohydrate analysis of adapting E. coli populations revealed an up-regulation of enzymes associated with the TCA cycle and amino acid metabolism and an increase in the secretion of putrescine. The overall effect of adaptation across populations is to redirect and efficiently utilize uptake and catabolism of abundant amino acids. Concomitantly, there is a pronounced spread of more ecologically limited strains that results from specialization through metabolic erosion. Remarkably, the global regulators arcA and rpoS can provide a one-step mechanism of adaptation to a novel environment, which highlights the importance of global resource management as a powerful strategy to adaptation.

  17. Waste Cleanup: Status and Implications of Compliance Agreements Between DOE and Its Regulators

    SciTech Connect (OSTI)

    Jones, G. L.; Swick, W. R.; Perry, T. C.; Kintner-Meyer, N.K.; Abraham, C. R.; Pollack, I. M.

    2003-02-26

    This paper discusses compliance agreements that affect the Department of Energy's (DOE) cleanup program. Compliance agreements are legally enforceable documents between DOE and its regulators, specifying cleanup activities and milestones that DOE has agreed to achieve. Over the years, these compliance agreements have been used to implement much of the cleanup activity at DOE sites, which is carried our primarily under two federal laws - the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended (CERCLA) and the Resource Conservation and Recovery Act of 0f 1976, as amended (RCRA). Our objectives were to determine the types of compliance agreements in effect at DOE cleanup sites, DOE's progress in achieving the milestones contained in the agreements, whether the agreements allowed DOE to prioritize work across sites according to relative risk, and possible implications the agreements have on DOE's efforts to improve the cleanup program.

  18. "A Regulator's Privacy Guide to Third-Party Data Access for Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    "A Regulator's Privacy Guide to Third-Party Data Access for Energy Efficiency" Now Available "A Regulator's Privacy Guide to Third-Party Data Access for Energy Efficiency" Now...

  19. REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST...

    Office of Scientific and Technical Information (OSTI)

    REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW ... Title: REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW ...

  20. 2 CCR 402-10 - Rules and Regulations for Geothermal Well Permitting...

    Open Energy Info (EERE)

    2 CCR 402-10 - Rules and Regulations for Geothermal Well PermittingLegal Abstract Sets forth regulation for issuance of geothermal well permits by the Division of Water Resources....

  1. State Air Emission Regulations That Affect Electric Power Producers (Update) (released in AEO2006)

    Reports and Publications (EIA)

    2006-01-01

    Several states have recently enacted air emission regulations that will affect the electricity generation sector. The regulations govern emissions of NOx, SO2, CO2, and mercury from power plants.

  2. Subject: Proposed 216(h) Regulations To: Brian.Mills@hq.doe...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    February 12, 2012 Subject: Proposed 216(h) Regulations To: Brian.Mills@hq.doe.gov and Lot.Cooke@hq.doe.gov. We appreciate the opportunity to review the Proposed Regulation for ...

  3. Enforcement Regulations and Directives - Nuclear Safety | Department of

    Energy Savers [EERE]

    Energy Nuclear Safety Enforcement Regulations and Directives - Nuclear Safety 10 C.F.R. Part 820 and Amendments 10 C.F.R. Part 820 - Procedural Rules for DOE Nuclear Activities 10 C.F.R. Part 820 - Procedural Rules for DOE Nuclear Activities; General Statement of Enforcement Policy; Final rule; amendment of enforcement policy statement and confirmation of interim rule Enforcement Guidance Supplements 10 C.F.R. Part 830 10 C.F.R. Part 830 - Nuclear Safety Management; Final Rule Office of

  4. CEQ Regulations for Implementing the Procedural Provisions of NEPA

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Council on Environmental Quality Executive Office of the President REGULATIONS For Implementing The Procedural Provisions Of The NATIONAL ENVIRONMENTAL POLICY ACT Reprint 40 CFR Parts 1500-1508 (2005) This page is blank (inside front cover) TABLE OF CONTENTS PART 1500-PURPOSE, POLICY AND MANDATE Sec. 1500.1 Purpose. 1500.2 Policy. 1500.3 Mandate. 1500.4 Reducing paperwork. 1500.5 Reducing delay. 1500.6 Agency authority. PART 1501-NEPA AND AGENCY PLANNING Sec. 1501.1 Purpose. 1501.2 Apply NEPA

  5. Federal Supply Schedules References Federal Acquisition Regulation (FAR) Subparts

    Office of Environmental Management (EM)

    -Chapter 8.4 (June 2011) 1 Federal Supply Schedules References Federal Acquisition Regulation (FAR) Subparts 1.1 Purpose, Authority, Issuance - 1.108 FAR conventions 2.1 Definitions 5.3 Synopses of Contract Awards 5.4 Release of Information 6 Competition Requirements 8.4 Federal Supply Schedules 9.1 Responsible Prospective Contractors - 9.105 Procedures 9.4 Debarment, Suspension and Ineligibility - 9.406 Debarment and 9.407 Suspension 12 Acquisition of Commercial Items 12.4 Unique Requirements

  6. Effect of confining wall potential on charged collimated dust beam in low-pressure plasma

    SciTech Connect (OSTI)

    Kausik, S. S.; Kakati, B.; Saikia, B. K. [Centre of Plasma Physics, Institute for Plasma Research, Sonapur 782 402 (India)] [Centre of Plasma Physics, Institute for Plasma Research, Sonapur 782 402 (India)

    2013-05-15

    The effect of confining wall potential on charged collimated dust beam in low-pressure plasma has been studied in a dusty plasma experimental setup by applying electrostatic field to each channel of a multicusp magnetic cage. Argon plasma is produced by hot cathode discharge method at a pressure of 510{sup ?4} millibars and is confined by a full line cusped magnetic field confinement system. Silver dust grains are produced by gas-evaporation technique and move upward in the form of a collimated dust beam due to differential pressure maintained between the dust and plasma chambers. The charged grains in the beam after coming out from the plasma column enter into the diagnostic chamber and are deflected by a dc field applied across a pair of deflector plates at different confining potentials. Both from the amount of deflection and the floating potential, the number of charges collected by the dust grains is calculated. Furthermore, the collimated dust beam strikes the Faraday cup, which is placed above the deflector plates, and the current (?pA) so produced is measured by an electrometer at different confining potentials. The experimental results demonstrate the significant effect of confining wall potential on charging of dust grains.

  7. "Frequently Asked Questions" on the Department of Energy's NEPA Regulations

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy "Frequently Asked Questions" on the Department of Energy's NEPA Regulations "Frequently Asked Questions" on the Department of Energy's NEPA Regulations Answers to frequently asked questions regarding DOE's NEPA implementation regulations. PDF icon Revised "Frequently Asked Questions on the Department of Energy's NEPA Regulations More Documents & Publications Questions and Answers on the Secretarial Policy Statement on NEPA Benefits of

  8. Guide to Federal Regulation of Sales of Imported Electricity in Canada,

    Energy Savers [EERE]

    Mexico and the United States | Department of Energy Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States A Publication of The North American Energy Working Group on January 2005 PDF icon Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States More Documents & Publications North America: Regulation of

  9. "Cybersecurity for State Regulators" - NARUC Primer (June 2012) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy "Cybersecurity for State Regulators" - NARUC Primer (June 2012) "Cybersecurity for State Regulators" - NARUC Primer (June 2012) The National Association of Regulatory Utility Commissioners (NARUC) released "Cybersecurity for State Regulators," a primer that explains conceptual cybersecurity basics and points to additional resources that can help regulators develop internal cybersecurity expertise, ask questions of their utilities, engage in

  10. Using regulations.gov to find dockets and documents | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Using regulations.gov to find dockets and documents Using regulations.gov to find dockets and documents A document from the U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy, Building Technologies Office, explaining how to use Regulations.gov to find dockets and documents. PDF icon as_accessing_documents.pdf More Documents & Publications Regulations.gov - Proposed Rule Document ISSUANCE 2015-08-21: Energy Conservation Program for Consumer Products: Energy

  11. On-shift training of plant personnel on environmental, safety and health regulations

    SciTech Connect (OSTI)

    Miller, D.

    1996-08-01

    As one of the standing committees under the American Petroleum Institute (API) General Committee of Refining, the Central Committee on Training and Development has several goals. These include improving plant operations and maintenance, reducing occupational injuries and illnesses, reducing the incidence of fires, maintaining effective environmental controls, and improving plant security. An additional responsibility is to develop cost and resource effective training materials. One of the activities the committee uses to achieve its goal is by sponsoring a series of biannual regional training conferences that attract participants from a variety of refineries and petrochemical plants. During the 1995 Spring Conferences, conference attendees were asked if on-shift training of plant personnel on environmental, safety and health was being utilized to assist compliance efforts and to achieve cost and resource effective training. In general, use of on-shift training is increasingly finding acceptance among the sites. One west coast refiner reported that their refinery had implemented a program of on-shift training for plant personnel on all environmental, safety and health regulations, and had achieved nearly one-hundred percent compliance through the first quarter of the effort.

  12. MEIS1 functions as a potential AR negative regulator

    SciTech Connect (OSTI)

    Cui, Liang; Yang, Yutao; Hang, Xingyi; Cui, Jiajun; Gao, Jiangping

    2014-10-15

    The androgen receptor (AR) plays critical roles in human prostate carcinoma progression and transformation. However, the activation of AR is regulated by co-regulators. MEIS1 protein, the homeodomain transcription factor, exhibited a decreased level in poor-prognosis prostate tumors. In this study, we investigated a potential interaction between MEIS1 and AR. We found that overexpression of MEIS1 inhibited the AR transcriptional activity and reduced the expression of AR target gene. A potential proteinprotein interaction between AR and MEIS1 was identified by the immunoprecipitation and GST pull-down assays. Furthermore, MEIS1 modulated AR cytoplasm/nucleus translocation and the recruitment to androgen response element in prostate specific antigen (PSA) gene promoter sequences. In addition, MEIS1 promoted the recruitment of NCoR and SMRT in the presence of R1881. Finally, MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells. Taken together, our data suggests that MEIS1 functions as a novel AR co-repressor. - Highlights: A potential interaction was identified between MEIS1 and AR signaling. Overexpression of MEIS1 reduced the expression of AR target gene. MEIS1 modulated AR cytoplasm/nucleus translocation. MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells.

  13. Nickel-regulated heart rate variability: The roles of oxidative stress and inflammation

    SciTech Connect (OSTI)

    Chuang, Hsiao-Chi; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan ; Hsueh, Tzu-Wei; Chang, Chuen-Chau; Hwang, Jing-Shiang; Chuang, Kai-Jen; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan ; Yan, Yuan-Horng; Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan ; Cheng, Tsun-Jen; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan

    2013-01-15

    Heart rate variability (HRV) has been reported to be a putative marker of cardiac autonomic imbalance caused by exposure to ambient particulate matter (PM). Our objective in this study was to determine the effects on HRV from exposure to nickel, an important chemical component of ambient PM that results in oxidative stress and inflammation. HRV data were collected for 72 h before lung exposure (baseline) and 72 h after intratracheal exposure (response) to nickel sulphate (NiSO{sub 4}; 526 ?g) in Wistar Kyoto (WKY) and spontaneously hypertensive (SH) rats. The antioxidant N-acetyl-L-cysteine (NAC) and the anti-inflammatory celecoxib were intraperitoneally injected to examine post-exposure oxidative and inflammatory responses. Self-controlled experiments examined the effects of NiSO{sub 4} exposure on average normal-to-normal intervals (ANN), natural logarithm-transformed standard deviation of the normal-to-normal intervals (LnSDNN) and root mean square of successive differences of adjacent normal-to-normal intervals (LnRMSSD); the resulting data were sequentially analysed using the generalised estimating equation model. HRV effects on NiSO{sub 4}-exposed SH rats were greater than those on NiSO{sub 4}-exposed WKY rats. After adjusted the HRV responses in the WKY rats as control, ANN and LnRMSSD were found to be quadratically increased over 72 h after exposure to NiSO{sub 4}. Both NAC and celecoxib mitigated the NiSO{sub 4}-induced alterations in HRV during the exposure period. The results suggest that concurrent Ni-induced oxidative stress and inflammatory responses play important roles in regulating HRV. These findings help bridge the gap between epidemiological and clinical studies on the plausible mechanisms of the cardiovascular consequences induced by chemical components in ambient PM. -- Highlights: ? To determine the effects on HRV from exposure to nickel. ? ANN and LnRMSSD were found to be quadratically increased after exposure to Ni. ? NAC and celecoxib mitigated the Ni-induced alterations in HRV. ? Ni-induced oxidative stress and inflammation play the roles in regulating HRV.

  14. WAC - 173-401 Operating Permit Regulation | Open Energy Information

    Open Energy Info (EERE)

    Washington state air operating permit program consistent with the requirements of Title V of the Federal Clean Air Act. Published NA Year Signed or Took Effect 1993 Legal...

  15. EO 13211: Regulations That Significantly Affect Energy Supply...

    Office of Environmental Management (EM)

    Distribution, or Use I am requiring that agencies shall prepare a Statement of Energy Effects when undertaking certain agency actions. As described more fully below, such...

  16. Modeling of GE Appliances: Cost Benefit Study of Smart Appliances in Wholesale Energy, Frequency Regulation, and Spinning Reserve Markets

    SciTech Connect (OSTI)

    Fuller, Jason C.; Parker, Graham B.

    2012-12-31

    This report is the second in a series of three reports describing the potential of GE’s DR-enabled appliances to provide benefits to the utility grid. The first report described the modeling methodology used to represent the GE appliances in the GridLAB-D simulation environment and the estimated potential for peak demand reduction at various deployment levels. The third report will explore the technical capability of aggregated group actions to positively impact grid stability, including frequency and voltage regulation and spinning reserves, and the impacts on distribution feeder voltage regulation, including mitigation of fluctuations caused by high penetration of photovoltaic distributed generation. In this report, a series of analytical methods were presented to estimate the potential cost benefit of smart appliances while utilizing demand response. Previous work estimated the potential technical benefit (i.e., peak reduction) of smart appliances, while this report focuses on the monetary value of that participation. The effects on wholesale energy cost and possible additional revenue available by participating in frequency regulation and spinning reserve markets were explored.

  17. Structural basis of AMPK regulation by adenine nucleotides and glycogen

    SciTech Connect (OSTI)

    Li, Xiaodan; Wang, Lili; Zhou, X. Edward; Ke, Jiyuan; de Waal, Parker W.; Gu, Xin; Tan, M. H. Eileen; Wang, Dongye; Wu, Donghai; Xu, H. Eric; Melcher, Karsten

    2014-11-21

    AMP-activated protein kinase (AMPK) is a central cellular energy sensor and regulator of energy homeostasis, and a promising drug target for the treatment of diabetes, obesity, and cancer. Here we present low-resolution crystal structures of the human ?1?2?1 holo-AMPK complex bound to its allosteric modulators AMP and the glycogen-mimic cyclodextrin, both in the phosphorylated (4.05 ) and non-phosphorylated (4.60 ) state. In addition, we have solved a 2.95 structure of the human kinase domain (KD) bound to the adjacent autoinhibitory domain (AID) and have performed extensive biochemical and mutational studies. Together, these studies illustrate an underlying mechanism of allosteric AMPK modulation by AMP and glycogen, whose binding changes the equilibria between alternate AID (AMP) and carbohydrate-binding module (glycogen) interactions.

  18. Regulation and Function of Adult Neurogenesis. From Genes to Cognition

    SciTech Connect (OSTI)

    Aimone, J. B.; Li, Y.; Lee, S. W.; Clemenson, G. D.; Deng, W.; Gage, F. H.

    2014-10-01

    Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. Our review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. Furthermore, the increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.

  19. Federal Air Emissions Regulations (released in AEO2006)

    Reports and Publications (EIA)

    2006-01-01

    In 2005, the Environmental Protection Agency (EPA) finalized two regulations, the Clean Air Interstate Rule (CAIR) and the Clean Air Mercury Rule CAMR, that would reduce emissions from coal-fired power plants in the United States. Both CAIR and CAMR are included in the Annual Energy Outlook 2006 reference case. The EPA has received 11 petitions for reconsideration of CAIR and has provided an opportunity for public comment on reconsidering certain aspects of CAIR. Public comments were accepted until January 13, 2006. The EPA has also received 14 petitions for reconsideration of CAMR and is willing to reconsider certain aspects of the rule. Public comments were accepted for 45 days after publication of the reconsideration notice in the Federal Register. Several states and organizations have filed lawsuits against CAMR. The ultimate decision of the courts will have a significant impact on the implementation of CAMR.

  20. Regulation control and energy management scheme for wireless power transfer

    DOE Patents [OSTI]

    Miller, John M.

    2015-12-29

    Power transfer rate at a charging facility can be maximized by employing a feedback scheme. The state of charge (SOC) and temperature of the regenerative energy storage system (RESS) pack of a vehicle is monitored to determine the load due to the RESS pack. An optimal frequency that cancels the imaginary component of the input impedance for the output signal from a grid converter is calculated from the load of the RESS pack, and a frequency offset f* is made to the nominal frequency f.sub.0 of the grid converter output based on the resonance frequency of a magnetically coupled circuit. The optimal frequency can maximize the efficiency of the power transfer. Further, an optimal grid converter duty ratio d* can be derived from the charge rate of the RESS pack. The grid converter duty ratio d* regulates wireless power transfer (WPT) power level.

  1. Regulation and Function of Adult Neurogenesis. From Genes to Cognition

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Aimone, J. B.; Li, Y.; Lee, S. W.; Clemenson, G. D.; Deng, W.; Gage, F. H.

    2014-10-01

    Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. Our review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages ofmore » maturation, ultimately integrating into the adult dentate gyrus network. Furthermore, the increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.« less

  2. Structural basis of AMPK regulation by adenine nucleotides and glycogen

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Xiaodan; Wang, Lili; Zhou, X. Edward; Ke, Jiyuan; de Waal, Parker W.; Gu, Xin; Tan, M. H. Eileen; Wang, Dongye; Wu, Donghai; Xu, H. Eric; et al

    2014-11-21

    AMP-activated protein kinase (AMPK) is a central cellular energy sensor and regulator of energy homeostasis, and a promising drug target for the treatment of diabetes, obesity, and cancer. Here we present low-resolution crystal structures of the human α1β2γ1 holo-AMPK complex bound to its allosteric modulators AMP and the glycogen-mimic cyclodextrin, both in the phosphorylated (4.05 Å) and non-phosphorylated (4.60 Å) state. In addition, we have solved a 2.95 Å structure of the human kinase domain (KD) bound to the adjacent autoinhibitory domain (AID) and have performed extensive biochemical and mutational studies. Altogether, these studies illustrate an underlying mechanism of allostericmore » AMPK modulation by AMP and glycogen, whose binding changes the equilibria between alternate AID (AMP) and carbohydrate-binding module (glycogen) interactions.« less

  3. NUCLEAR REGULATOR%'-C~fiMls6N REGION I

    Office of Legacy Management (LM)

    jNrTED ST&ye ^ = I\ ) r P, NUCLEAR REGULATOR%'-C~fiMls6N REGION I 63I PIIRK AVENUE Wcs:in;kcse Elecric Coroorrzion ATTiN: 2. F:. jhaw I=-- Zivision Piant Manaaer wm.1.1 I SJeszi nszcuse PY LZC w 5:oscifeic, blew Jersey c7003 Sgkjerz: Inspection $002286/S:-01 T+is refe-s ta the s?ecf2.! s2' :ety -yi <nsoecrion conducted by Ms. M. Camobell of WI *S cSf4ce on Jenczry 29, 296; a: p2-f:; 27: co ccti vi ti es aurhorfzed by NRC Li cekse No 3ckr: tne dlsrussions of our findings he'ld by Mr. M.

  4. Extracellular calmodulin regulates growth and cAMP-mediated chemotaxis in Dictyostelium discoideum

    SciTech Connect (OSTI)

    O'Day, Danton H.; Huber, Robert J.; Suarez, Andres

    2012-09-07

    Highlights: Black-Right-Pointing-Pointer Extracellular calmodulin is present throughout growth and development in Dictyostelium. Black-Right-Pointing-Pointer Extracellular calmodulin localizes within the ECM during development. Black-Right-Pointing-Pointer Extracellular calmodulin inhibits cell proliferation and increases chemotaxis. Black-Right-Pointing-Pointer Extracellular calmodulin exists in eukaryotic microbes. Black-Right-Pointing-Pointer Extracellular calmodulin may be functionally as important as intracellular calmodulin. -- Abstract: The existence of extracellular calmodulin (CaM) has had a long and controversial history. CaM is a ubiquitous calcium-binding protein that has been found in every eukaryotic cell system. Calcium-free apo-CaM and Ca{sup 2+}/CaM exert their effects by binding to and regulating the activity of CaM-binding proteins (CaMBPs). Most of the research done to date on CaM and its CaMBPs has focused on their intracellular functions. The presence of extracellular CaM is well established in a number of plants where it functions in proliferation, cell wall regeneration, gene regulation and germination. While CaM has been detected extracellularly in several animal species, including frog, rat, rabbit and human, its extracellular localization and functions are less well established. In contrast the study of extracellular CaM in eukaryotic microbes remains to be done. Here we show that CaM is constitutively expressed and secreted throughout asexual development in Dictyostelium where the presence of extracellular CaM dose-dependently inhibits cell proliferation but increases cAMP mediated chemotaxis. During development, extracellular CaM localizes within the slime sheath where it coexists with at least one CaMBP, the matricellular CaM-binding protein CyrA. Coupled with previous research, this work provides direct evidence for the existence of extracellular CaM in the Dictyostelium and provides insight into its functions in this model amoebozoan.

  5. Discoidin domain receptor 2 (DDR2) regulates proliferation of endochondral cells in mice

    SciTech Connect (OSTI)

    Kawai, Ikuma; Hisaki, Tomoka; Sugiura, Koji; Naito, Kunihiko; Kano, Kiyoshi; Biomedical Science Center for Translational Research , The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515

    2012-10-26

    Highlights: Black-Right-Pointing-Pointer Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase. Black-Right-Pointing-Pointer DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. Black-Right-Pointing-Pointer We produced in vitro and in vivo model to better understand the role of DDR2. Black-Right-Pointing-Pointer DDR2 might play an inhibitory role in the proliferation of chondrocyte. -- Abstract: Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in murine preosteoblastic cells, but the functions of DDR2 in chondrogenic cellular proliferation remain unclear. To better understand the role of DDR2 signaling in cellular proliferation in endochondral ossification, we inhibited Ddr2 expression via the inhibitory effect of miRNA on Ddr2 mRNA (miDdr2) and analyzed the cellular proliferation and differentiation in the prechondrocyte ATDC5 cell lines. To investigate DDR2's molecular role in endochondral cellular proliferation in vivo, we also produced transgenic mice in which the expression of truncated, kinase dead (KD) DDR2 protein is induced, and evaluated the DDR2 function in cellular proliferation in chondrocytes. Although the miDdr2-transfected ATDC5 cell lines retained normal differentiation ability, DDR2 reduction finally promoted cellular proliferation in proportion to the decreasing ratio of Ddr2 expression, and it also promoted earlier differentiation to cartilage cells by insulin induction. The layer of hypertrophic chondrocytes in KD Ddr2 transgenic mice was not significantly thicker than that of normal littermates, but the layer of proliferative chondrocytes in KD-Ddr2 transgenic mice was significantly thicker than that of normal littermates. Taken together, our data demonstrated that DDR2 might play a local and essential role in the proliferation of chondrocytes.

  6. A linear MOSFET regulator for improving performance of the booster ramping power supplies at the APS.

    SciTech Connect (OSTI)

    Feng, G.; Deriy, B.; Wang, J.; Accelerator Systems Division

    2008-01-01

    The APS booster ring uses ramping power supplies to power the sextupole, quadrupole, and dipole magnets as the beam energy ramps up linearly to 7 GeV. Due to the circuit topology used, those supplies are unable to follow the linear ramp to the desired accuracy. The best regulation achieved is 0.25% while 0.1% is desired. In addition to the unsatisfying regulation, those supplies are sensitive to AC line perturbation and are not able to reject AC line noises of more than a few tens of hertz. To improve the performance, a linear MOSFET regulation system using paralleled MOSFET devices in series with the power supply is proposed. The system uses a realtime current feedback loop to force the MOSFETs to work in the linear operation mode. By using this linear MOSFET regulator, the voltage drop on MOSFETs, and hence the voltage imposed on magnets, can be regulated very quickly. As a result, the regulation of the magnet current can be improved significantly. So far the simulation results show that with the linear regulator, the current regulation can be improved to better than 0.1%. Because of the high bandwidth of the linear regulator, it can reduce the harmonic content in the output current as well as reject the AC line disturbance. This paper discusses the circuit topology, the regulation method, and the simulation results.

  7. 50 CFR 216: Subpart I - General Regulations Governing Small Takes...

    Open Energy Info (EERE)

    taking of small numbers of marine mammals by U.S. citizens who engage in a specified activity within a specified geographic region. Published NA Year Signed or Took Effect...

  8. Regulations, Policies and Strategies for LLRW Management in Bangladesh - 12368

    SciTech Connect (OSTI)

    Mollah, A.S.

    2012-07-01

    Low level radioactive waste (LLW) is generated from various nuclear applications in Bangladesh. The major sources of radioactive waste in the country are at present: (a) the 3 MW TRIGA Mark-II research reactor; (b) the radioisotope production facility; (c) the medical, industrial and research facilities that use radionuclides; and (d) the industrial facility for processing monazite sands. Radioactive waste needs to be safely managed because it is potentially hazardous to human health and the environment. According to Nuclear Safety and Radiation Control Act-93, the Bangladesh Atomic Energy Commission (BAEC) is the governmental body responsible for the receipt and final disposal of radioactive wastes in the whole country. Waste management policy has become an important environmental, social, and economical issue for LLW in Bangladesh. Policy and strategies will serve as a basic guide for radioactive waste management in Bangladesh. The waste generator is responsible for on-site collection, conditioning and temporary storage of the waste arising from his practice. The Central Waste Processing and Storage Unit (CWPSU) of BAEC is the designated national facility with the requisite facility for the treatment, conditioning and storage of radioactive waste until a final disposal facility is established and becomes operational. The Regulatory Authority is responsible for the enforcement of compliance with provisions of the waste management regulation and other relevant requirements by the waste generator and the CWPSU. The objective of this paper is to present, in a concise form, basic information about the radioactive waste management infrastructure, regulations, policies and strategies including the total inventory of low level radioactive waste in the country. For improvement and strengthening in terms of operational capability, safety and security of RW including spent radioactive sources and overall security of the facility (CWPSF), the facility is expected to serve waste management need in the country and, in the course of time, the facility may be turned into a regional level training centre. It is essential for safe conduction and culture of research and application in nuclear science and technology maintaining the relevant safety of man and environment and future generations to come. (authors)

  9. Role of a Transcriptional Regulator in Programmed Cell Death and Plant Development

    SciTech Connect (OSTI)

    Julie M. Stone

    2008-09-13

    The long-term goal of this research is to understand the role(s) and molecular mechanisms of programmed cell death (PCD) in the controlling plant growth, development and responses to biotic and abiotic stress. We developed a genetic selection scheme to identify A. thaliana FB1-resistant (fbr) mutants as a way to find genes involved in PCD (Stone et al., 2000; Stone et al., 2005; Khan and Stone, 2008). The disrupted gene in fbr6 (AtSPL14) responsible for the FB1-insensitivity and plant architecture phenotypes encodes a plant-specific SBP DNA-binding domain transcriptional regulator (Stone et al., 2005; Liang et al., 2008). This research plan is designed to fill gaps in the knowledge about the role of SPL14 in plant growth and development. The work is being guided by three objectives aimed at determining the pathways in which SPL14 functions to modulate PCD and/or plant development: (1) determine how SPL14 functions in plant development, (2) identify target genes that are directly regulated by SPL14, and (3) identify SPL14 modifications and interacting proteins. We made significant progress during the funding period. Briefly, some major accomplishments are highlighted below: (1) To identify potential AtSPL14 target genes, we identified a consensus DNA binding site for the AtSPL14 SBP DNA-binding domain using systematic evolution of ligands by exponential selection (SELEX) and site-directed mutagenesis (Liang et al., 2008). This consensus binding site was used to analyze Affymetrix microarray gene expression data obtained from wild-type and fbr6 mutant plants to find possible AtSPL14-regulated genes. These candidate AtSPL14-regulated genes are providing new information on the molecular mechanisms linking plant PCD and plant development through modulation of the 26S proteasome. (2) Transgenic plants expressing epitope-tagged versions of AtSPL14 are being used to confirm the AtSPL14 targets (by ChIP-PCR) and further dissect the molecular interactions (Nazarenus, Liang and Stone, in preparation) (3) Double mutants generated between fbr6 and various accelerated cell death (acd) mutants indicate that sphingolipid metabolism is influenced by AtSPL14 and sphingolipidomics profiling supports this conclusion (Lin, Markham and Stone, in preparation). (4) A new set of phenotypes have been uncovered in the original fbr6-1 mutant, including a short-root phenotype related to auxin signaling and altered photosynthetic parameters related to stomatal density and conductance (Lin and Stone, in preparation; Lin, Madhavan and Stone, in preparation). Additional AtSPL14-related mutants and transgenic plants have been generated to effectively dissect the functions of AtSPL14, including a dominant negative fbr6-2 allele and transgenic plants overexpressing FBR6/AtSPL14 that display an accelerated cell death (acd) phenotype.

  10. Fact Sheet: Beacon Power 20 MW Flywheel Frequency Regulation Plant (August

    Energy Savers [EERE]

    2013) | Department of Energy Beacon Power 20 MW Flywheel Frequency Regulation Plant (August 2013) Fact Sheet: Beacon Power 20 MW Flywheel Frequency Regulation Plant (August 2013) Beacon Power will design, build, and operate a utility-scale 20 MW flywheel energy storage plant at the Humboldt Industrial Park in Hazle Township, PA for Hazle Spindle LLC. The plant will provide frequency regulation services to grid operator PJM Interconnection. For more information about how OE performs research

  11. Policy Flash 2013-23 Department of Energy Acquisition Regulation (DEAR)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Final Rule for changes to Parts 908, 945, 952, and 970 regarding Government Property | Department of Energy 3 Department of Energy Acquisition Regulation (DEAR) Final Rule for changes to Parts 908, 945, 952, and 970 regarding Government Property Policy Flash 2013-23 Department of Energy Acquisition Regulation (DEAR) Final Rule for changes to Parts 908, 945, 952, and 970 regarding Government Property Attached is Policy Flash 2013-23 Department of Energy Acquisition Regulation (DEAR) Final

  12. Methods, systems and apparatus for synchronous current regulation of a five-phase machine

    DOE Patents [OSTI]

    Gallegos-Lopez, Gabriel; Perisic, Milun

    2012-10-09

    Methods, systems and apparatus are provided for controlling operation of and regulating current provided to a five-phase machine when one or more phases has experienced a fault or has failed. In one implementation, the disclosed embodiments can be used to synchronously regulate current in a vector controlled motor drive system that includes a five-phase AC machine, a five-phase inverter module coupled to the five-phase AC machine, and a synchronous current regulator.

  13. System and method for regulating EGR cooling using a rankine cycle

    DOE Patents [OSTI]

    Ernst, Timothy C.; Morris, Dave

    2015-12-22

    This disclosure relates to a waste heat recovery (WHR) system and method for regulating exhaust gas recirculation (EGR) cooling, and more particularly, to a Rankine cycle WHR system and method, including a recuperator bypass arrangement to regulate EGR exhaust gas cooling for engine efficiency improvement and thermal management. This disclosure describes other unique bypass arrangements for increased flexibility in the ability to regulate EGR exhaust gas cooling.

  14. Improving the regulation of safety at DOE nuclear facilities. Final report: Appendices

    SciTech Connect (OSTI)

    1995-12-01

    The report strongly recommends that, with the end of the Cold War, safety and health at DOE facilities should be regulated by outside agencies rather than by any regulatory scheme, DOE must maintain a strong internal safety management system; essentially all aspects of safety at DOE`s nuclear facilities should be externally regulated; and existing agencies rather than a new one should be responsible for external regulation.

  15. Study of the impacts of regulations affecting the acceptance of integrated

    Office of Scientific and Technical Information (OSTI)

    community energy systems. Final report (Technical Report) | SciTech Connect Study of the impacts of regulations affecting the acceptance of integrated community energy systems. Final report Citation Details In-Document Search Title: Study of the impacts of regulations affecting the acceptance of integrated community energy systems. Final report A detailed description is presented of the laws and programs of the State of North Carolina governing the regulation of public energy utilities, the

  16. HDAC3 regulates stability of estrogen receptor ? mRNA

    SciTech Connect (OSTI)

    Oie, Shohei; Matsuzaki, Kazuya; Yokoyama, Wataru; Murayama, Akiko; Yanagisawa, Junn

    2013-03-08

    Highlights: ? HDAC inhibitors decrease the stability of ER? mRNA in MCF-7 cells. ? HDAC3 is involved in maintaining ER? mRNA stability in MCF-7 cells. ? ER? mRNA instability by knockdown of HDAC3 reduces the estrogen-dependent proliferation of ER?-positive MCF-7 cells. ? HDAC3 specific inhibitor will be one of new drugs for ER?-positive breast cancers. -- Abstract: Estrogen receptor alpha (ER?) expression is a risk factor for breast cancer. HDAC inhibitors have been demonstrated to down-regulate ER? expression in ER?-positive breast cancer cell lines, but the molecular mechanisms are poorly understood. Here, we showed that HDAC inhibitors decrease the stability of ER? mRNA, and that knockdown of HDAC3 decreases the stability of ER? mRNA and suppresses estrogen-dependent proliferation of ER?-positive MCF-7 breast cancer cells. In the Oncomine database, expression levels of HDAC3 in ER?-positive tumors are higher than those in ER?-negative tumors, thus suggesting that HDAC3 is necessary for ER? mRNA stability, and is involved in the estrogen-dependent proliferation of ER?-positive tumors.

  17. Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σE-regulated SPI-2 gene expression

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Jie; Overall, Christopher C.; Nakayasu, Ernesto S.; Kidwai, Afshan S.; Jones, Marcus B.; Johnson, Rudd; Nguyen, Nhu T.; McDermott, Jason E.; Ansong, Charles; Heffron, Fred; et al

    2015-02-10

    The extracytoplasmic functioning sigma factor σE is known to play an essential role for Salmonella enterica serovar Typhimurium to survive and proliferate in macrophages and mice. However, its regulatory network is not well characterized, especially during infection. Here we used microarray to identify genes regulated by σE in Salmonella grown in three conditions: a nutrient-rich condition and two others that mimic early and late intracellular infection. We found that in each condition σE regulated different sets of genes, and notably, several global regulators. When comparing nutrient-rich and infection-like conditions, large changes were observed in the expression of genes involved inmore » Salmonella pathogenesis island (SPI)-1 type-three secretion system (TTSS), SPI-2 TTSS, protein synthesis, and stress responses. In total, the expression of 58% of Salmonella genes was affected by σE in at least one of the three conditions. An important finding is that σE up-regulates SPI-2 genes, which are essential for Salmonella intracellular survival, by up-regulating SPI-2 activator ssrB expression at the early stage of infection and down-regulating SPI-2 repressor hns expression at a later stage. Moreover, σE is capable of countering the silencing of H-NS, releasing the expression of SPI-2 genes. This connection between σE and SPI-2 genes, combined with the global regulatory effect of σE, may account for the lethality of rpoE-deficient Salmonella in murine infection.« less

  18. Is Tritium over-regulated by DOE? Should the TFG support NA-1 SD G 1027

    Office of Environmental Management (EM)

    tritium values? | Department of Energy over-regulated by DOE? Should the TFG support NA-1 SD G 1027 tritium values? Is Tritium over-regulated by DOE? Should the TFG support NA-1 SD G 1027 tritium values? Presentation from the 32nd Tritium Focus Group Meeting held in Germantown, Maryland on April 23-25, 2013. PDF icon Is Tritium over-regulated by DOE? Should the TFG support NA-1 SD G 1027 tritium values? More Documents & Publications Is Tritium Over-Regulated, Part 2 Should The TFG

  19. 33 CFR Part 221 USACE Regulations for Work for Others | Open...

    Open Energy Info (EERE)

    Abstract This Part of the US Army Corps of Engineers' regulations provides procedures for working with other agencies including, processes for cooperating with FERC when...

  20. New York State`s regulations for low-level radioactive waste disposal facilities

    SciTech Connect (OSTI)

    Youngberg, B.; Merges, P.; Owen, K.

    1994-12-31

    The New York State Department of Environmental Conservation`s (NYSDEC) regulations for low-level radioactive waste (LLRW) disposal facilities set primarily performance-based criteria for LLRW disposal facilities. The regulations (Part 383 of Title 6 of the New York State Codes of Rules and Regulations) set requirements for design, construction, operation, monitoring, site safety planning, financial assurance, closure, post closure monitoring and maintenance, and institutional control. The regulations are unique in their detail and in presenting specific requirements for below ground disposal units, above ground disposal units, and underground mined repositories.

  1. REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST...

    Office of Scientific and Technical Information (OSTI)

    REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW STRATEGICALLY LOCATED AMERIFLUX TOWER SITE IN MISSOURI Pallardy, Stephen G 59 BASIC BIOLOGICAL...

  2. Regulated 2-Stage (R2S) Charging Systems for Future Diesel Application...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Applications Regulated 2-Stage (R2S) Charging Systems for Future Diesel Applications 2004 Diesel Engine Emissions Reduction (DEER) Conference Presentation: BorgWarner Turbo Systms...

  3. Colorado Code of Regulations 2 CCR 601-18, State Utility Accommodation...

    Open Energy Info (EERE)

    Colorado Code of Regulations 2 CCR 601-18, State Utility Accommodation Code (Redirected from CDOT - Rules Pertaining to Accommodating Utilities in the State Highway Rights of Way)...

  4. DOE Seeks Public Views On How Best To Streamline Existing Regulations

    Broader source: Energy.gov [DOE]

    The Department of Energy today announced two immediate steps to implement the Obama Administration's Executive Order on Improving Regulation and Regulatory Review, which directs federal agencies to...

  5. Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency

    Broader source: Energy.gov [DOE]

    The Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency (GC-33) provides legal support and advice on legislative matters throughout the Department. It...

  6. Code of Colorado Regulations 5 CCR 1002-61, Colorado Discharge...

    Open Energy Info (EERE)

    Code of Colorado Regulations 5 CCR 1002-61, Colorado Discharge Permit System Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  7. 2012 CERTS LAAR Program Peer Review - Load as a Regulation Resource...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Load as a Regulation Resource Sila Kiliccote, Jason MacDonald, Livio Fenga and Dave Watson Demand Response Research Center Grid Integration Group Lawrence Berkeley National ...

  8. Designing Effective State Programs for the Industrial Sector - New SEE

    Office of Environmental Management (EM)

    Action Publication | Department of Energy Designing Effective State Programs for the Industrial Sector - New SEE Action Publication Designing Effective State Programs for the Industrial Sector - New SEE Action Publication March 24, 2014 - 12:56pm Addthis Industrial Energy Efficiency: Designing Effective State Programs for the Industrial Sector provides state regulators, utilities, and other program administrators with an overview of U.S. industrial energy efficiency programs delivered by a

  9. Smart Grid Newsletter …TheRegulators Role in Grid ModernizationŽ or Leadership from State Regulators can make the Smart G

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Title: "The Regulator's Role in Grid Modernization" Sponsor: The Modern Grid Strategy is a DOE-funded project conducted by the National Energy Technology Laboratory Leadership from state regulators can make the Smart Grid a reality In previous articles we discussed the principal characteristics that define a Modern (Smart) Grid. Armed with a much clearer understanding of what is a modern grid, and what technologies it will employ, we can now address a number of less technical issues.

  10. JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats

    SciTech Connect (OSTI)

    Guo, Xinjin [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian (China); Meng, Qiang; Liu, Qi; Wang, Changyuan; Sun, Huijun; Peng, Jinyong; Ma, Xiaochi [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian (China); Provincial Key Laboratory for Pharmacokinetics and Transport, Dalian Medical University, Liaoning (China); Kaku, Taiichi [Japan Bioproducts Industry Co. Ltd., Tomigaya, Shibuya-ku, Tokyo (Japan); Liu, Kexin, E-mail: kexinliu@dlmedu.edu.cn [Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian (China); Provincial Key Laboratory for Pharmacokinetics and Transport, Dalian Medical University, Liaoning (China)

    2013-09-01

    We investigated the effects of JBP485 (an anti-inflammatory dipeptide and a substrate of OAT) on regulation of the expression and function of renal Oat1 and Oat3, which can accelerate the excretion of accumulated uremic toxins (e.g. indoxyl sulfate) in the kidney to improve gentamicin-induced ARF in rats. JBP485 caused a significant decrease in the accumulation of endogenous substances (creatinine, blood urea nitrogen and indoxyl sulfate) in vivo, an increase in the excretion of exogenous compounds (lisinopril and inulin) into urine, and up-regulation of the expressions of renal Oat1 and Oat3 in the kidney tissues and slices via substrate induction. To determine the effect of JBP485 on the accelerated excretion of uremic toxins mediated by Oat1 and Oat3, the mRNA and protein expression levels of renal basolateral Oats were assessed by quantitative real-time PCR, western blot, immunohistochemical analysis and an immunofluorescence method. Gentamicin down-regulated the expression of Oats mRNA and protein in rat kidney, and these effects were reversed after administration of JBP485. In addition, JBP485 caused a significant decrease in MPO and MDA levels in the kidney, and improved the pathological condition of rat kidney. These results indicated that JBP485 improved acute renal failure by increasing the expression and function of Oat1 and Oat3, and by decreasing overoxidation of the kidney in gentamicin-induced ARF rats. - Highlights: JBP485 could up-regulate function and expression of Oat1 and Oat3 in kidney. Effects of JBP485 on ARF are mediated by stimulating excretion of uremic toxins. JBP485 protected against gentamicin-induced ARF by decreasing MPO and MDA.

  11. A Test Bed for Self-regulating Distribution Systems: Modeling Intergrated Renewable Energy and Demand Response in the GridLAB-D/MATLAB Environment

    SciTech Connect (OSTI)

    Wang, Dan; de Wit, Braydon; Parkinson, Simon; Fuller, Jason C.; Chassin, David P.; Crawford, Curran; Djilali, Ned

    2012-01-16

    This paper discusses the development of a simulation test bed permitting the study of integrated renewable energy generators and controlled distributed heat pumps operating within distribution systems. The test bed is demonstrated in this paper by addressing the important issue of the self-regulating effect of consumer-owned air-source heat pumps on the variability induced by wind power integration, particularly when coupled with increased access to demand response realized through a centralized load control strategy.

  12. Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and

    Office of Scientific and Technical Information (OSTI)

    hypoxia-inducible factor-1 alpha (HIF-1{alpha}) and HIF-regulated genes (Journal Article) | SciTech Connect Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1{alpha}) and HIF-regulated genes Citation Details In-Document Search Title: Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1{alpha}) and HIF-regulated genes Several metal ions that are carcinogenic affect cellular iron

  13. Division of Natural Gas Regulation (Import/Export)- E-Filing

    Broader source: Energy.gov [DOE]

    Welcome to the Division of Natural Gas Regulation Electronic Filing System. The Import/Export Office regulates the import and export of natural gas under section 3 of the Natural Gas Act and 10 C.F...

  14. Brassinosteroid regulated kinases (BRKs) that mediate brassinosteroid signal transduction and uses thereof

    DOE Patents [OSTI]

    Wang, Zhi-Yong; Tang, Wenqiang

    2013-09-24

    The present invention identifies a novel family of kinases regulated by brassinosteroids, referred to as BRKs (brassinosteroid regulated kinases) or BSKs (brassinosteroid signaling kinases). The present invention provides methods for modulating the response of a plant cell to a brassinosteroid using BRKs.

  15. Using Cost-Effectiveness Tests to Design CHP Incentive Programs

    SciTech Connect (OSTI)

    Tidball, Rick

    2014-11-01

    This paper examines the structure of cost-effectiveness tests to illustrate how they can accurately reflect the costs and benefits of CHP systems. This paper begins with a general background discussion on cost-effectiveness analysis of DER and then describes how cost-effectiveness tests can be applied to CHP. Cost-effectiveness results are then calculated and analyzed for CHP projects in five states: Arkansas, Colorado, Iowa, Maryland, and North Carolina. Based on the results obtained for these five states, this paper offers four considerations to inform regulators in the application of cost-effectiveness tests in developing CHP programs.

  16. RNA Helicase DDX5 Regulates MicroRNA Expression and Contributes to Cytoskeletal Reorganization in Basal Breast Cancer Cells

    SciTech Connect (OSTI)

    Wang, Daojing; Huang, Jing; Hu, Zhi

    2011-11-15

    RNA helicase DDX5 (also p68) is involved in all aspects of RNA metabolism and serves as a transcriptional co-regulator, but its functional role in breast cancer remains elusive. Here, we report an integrative biology study of DDX5 in breast cancer, encompassing quantitative proteomics, global MicroRNA profiling, and detailed biochemical characterization of cell lines and human tissues. We showed that protein expression of DDX5 increased progressively from the luminal to basal breast cancer cell lines, and correlated positively with that of CD44 in the basal subtypes. Through immunohistochemistry analyses of tissue microarrays containing over 200 invasive human ductal carcinomas, we observed that DDX5 was upregulated in the majority of malignant tissues, and its expression correlated strongly with those of Ki67 and EGFR in the triple-negative tumors. We demonstrated that DDX5 regulated a subset of MicroRNAs including miR-21 and miR-182 in basal breast cancer cells. Knockdown of DDX5 resulted in reorganization of actin cytoskeleton and reduction of cellular proliferation. The effects were accompanied by upregulation of tumor suppressor PDCD4 (a known miR-21 target); as well as upregulation of cofilin and profilin, two key proteins involved in actin polymerization and cytoskeleton maintenance, as a consequence of miR-182 downregulation. Treatment with miR-182 inhibitors resulted in morphologic phenotypes resembling those induced by DDX5 knockdown. Using bioinformatics tools for pathway and network analyses, we confirmed that the network for regulation of actin cytoskeleton was predominantly enriched for the predicted downstream targets of miR-182. Our results reveal a new functional role of DDX5 in breast cancer via the DDX5?miR-182?actin cytoskeleton pathway, and suggest the potential clinical utility of DDX5 and its downstream MicroRNAs in the theranostics of breast cancer.

  17. Toxicology and cellular effect of manufactured nanomaterials

    DOE Patents [OSTI]

    Chen, Fanqing

    2014-07-22

    The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.

  18. Biologically based multistage modeling of radiation effects

    SciTech Connect (OSTI)

    William Hazelton; Suresh Moolgavkar; E. Georg Luebeck

    2005-08-30

    This past year we have made substantial progress in modeling the contribution of homeostatic regulation to low-dose radiation effects and carcinogenesis. We have worked to refine and apply our multistage carcinogenesis models to explicitly incorporate cell cycle states, simple and complex damage, checkpoint delay, slow and fast repair, differentiation, and apoptosis to study the effects of low-dose ionizing radiation in mouse intestinal crypts, as well as in other tissues. We have one paper accepted for publication in ''Advances in Space Research'', and another manuscript in preparation describing this work. I also wrote a chapter describing our combined cell-cycle and multistage carcinogenesis model that will be published in a book on stochastic carcinogenesis models edited by Wei-Yuan Tan. In addition, we organized and held a workshop on ''Biologically Based Modeling of Human Health Effects of Low dose Ionizing Radiation'', July 28-29, 2005 at Fred Hutchinson Cancer Research Center in Seattle, Washington. We had over 20 participants, including Mary Helen Barcellos-Hoff as keynote speaker, talks by most of the low-dose modelers in the DOE low-dose program, experimentalists including Les Redpath (and Mary Helen), Noelle Metting from DOE, and Tony Brooks. It appears that homeostatic regulation may be central to understanding low-dose radiation phenomena. The primary effects of ionizing radiation (IR) are cell killing, delayed cell cycling, and induction of mutations. However, homeostatic regulation causes cells that are killed or damaged by IR to eventually be replaced. Cells with an initiating mutation may have a replacement advantage, leading to clonal expansion of these initiated cells. Thus we have focused particularly on modeling effects that disturb homeostatic regulation as early steps in the carcinogenic process. There are two primary considerations that support our focus on homeostatic regulation. First, a number of epidemiologic studies using multistage carcinogenesis models that incorporate the ''initiation, promotion, and malignant conversion'' paradigm of carcinogenesis are indicating that promotion of initiated cells is the most important cellular mechanism driving the shape of the age specific hazard for many types of cancer. Second, we have realized that many of the genes that are modified in early stages of the carcinogenic process contribute to one or more of four general cellular pathways that confer a promotional advantage to cells when these pathways are disrupted.

  19. Distribution of air-water mixtures in parallel vertical channels as an effect of the header geometry

    SciTech Connect (OSTI)

    Marchitto, Annalisa; Fossa, Marco; Guglielmini, Giovanni

    2009-07-15

    Uneven phase distribution in heat exchangers is a cause of severe reductions in thermal performances of refrigeration equipment. To date, no general design rules are available to avoid phase separation in manifolds with several outlet channels, and even predicting the phase and mass distribution in parallel channels is a demanding task. In the present paper, measurements of two-phase air-water distributions are reported with reference to a horizontal header supplying 16 vertical upward channels. The effects of the operating conditions, the header geometry and the inlet port nozzle were investigated in the ranges of liquid and gas superficial velocities of 0.2-1.2 and 1.5-16.5 m/s, respectively. Among the fitting devices used, the insertion of a co-axial, multi-hole distributor inside the header confirmed the possibility of greatly improving the liquid and gas flow distribution by the proper selection of position, diameter and number of the flow openings between the supplying distributor and the system of parallel channels connected to the header. (author)

  20. Structure-based functional characterization of repressor of toxin (Rot), a central regulator of staphylococcus aureus virulence

    SciTech Connect (OSTI)

    Killikelly, April; Jakoncic, Jean; Benson, Meredith A.; Ohneck, Elizabeth A.; Sampson, Jared M.; Spurrier, Brett; Torres, Victoer J.; Kong, Xian -Peng

    2014-10-20

    Staphylococcus aureus is responsible for a large number of diverse infections worldwide. In order to support its pathogenic lifestyle, S. aureus has to regulate the expression of virulence factors in a coordinated fashion. One of the central regulators of the S. aureus virulence regulatory networks is the transcription factor repressor of toxin (Rot). Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors. However, the mechanism by which Rot mediates gene regulation has remained elusive. Here, we have determined the crystal structure of Rot and used this information to probe the contribution made by specific residues to Rot function. Rot was found to form a dimer, with each monomer harboring a winged helix-turn-helix (WHTH) DNA-binding motif. Despite an overall acidic pI, the asymmetric electrostatic charge profile suggests that Rot can orient the WHTH domain to bind DNA. Structure-based site-directed mutagenesis studies demonstrated that R91, at the tip of the wing, plays an important role in DNA binding, likely through interaction with the minor groove. We also found that Y66, predicted to bind within the major groove, contributes to Rot interaction with target promoters. Evaluation of Rot binding to different activated and repressed promoters revealed that certain mutations on Rot exhibit promoter-specific effects, suggesting for the first time that Rot differentially interacts with target promoters. As a result, this work provides insight into a precise mechanism by which Rot controls virulence factor regulation in S. aureus.

  1. Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression

    SciTech Connect (OSTI)

    Wang, Lei; Kuang, Lisha; Hitron, John Andrew; Son, Young-Ok; Wang, Xin; Budhraja, Amit; Lee, Jeong-Chae; Pratheeshkumar, Poyil; Chen, Gang; Zhang, Zhuo; Luo, Jia; Shi, Xianglin

    2013-10-01

    Environmental exposure to arsenic is known to cause various cancers. There are some potential relationships between cell malignant transformation and C-X-C chemokine receptor type 4 (CXCR4) expressions. Metastasis, one of the major characteristics of malignantly transformed cells, contributes to the high mortality of cells. CXCR4 and its natural chemokine ligand C-X-C motif ligand 12 (CXCL12) play a critical role in metastasis. Therefore, identification of nutritional factors which are able to inhibit CXCR4 is important for protection from environmental arsenic-induced carcinogenesis and for abolishing metastasis of malignantly transformed cells. The present study demonstrates that apigenin (4?,5,7-trihydroxyflavone), a natural dietary flavonoid, suppressed CXCR4 expression in arsenic-transformed Beas-2B cells (B-AsT) and several other types of transformed/cancer cells in a dose- and time-dependent manner. Neither proteasome nor lysosome inhibitor had any effect in reducing the apigenin-induced down-regulation of CXCR4, indicating that apigenin-induced down-regulation of CXCR4 is not due to proteolytic degradation. The down-regulation of CXCR4 is mainly due to the inhibition of nuclear factor ?B (NF-?B) transcriptional activity. Apigenin also abolished migration and invasion of transformed cells induced by CXCL12. In a xenograft mouse model, apigenin down-regulated CXCR4 expression and suppressed tumor growth. Taken together, our results show that apigenin is a novel inhibitor of CXCR4 expression. This dietary flavonoid has the potential to suppress migration and invasion of transformed cells and prevent environmental arsenic-induced carcinogenesis. - Highlights: Apigenin has a potential in preventing environmental arsenic induced carcinogenesis. Apigenin suppresses CXCR4 in malignant transformed cells in vitro and in vivo. The down-regulation of CXCR4 is mainly due to inhibition of NF-?B activity.

  2. Coordinated Regulation of Virulence during Systemic Infection of Salmonella enterica serovar Typhimurium

    SciTech Connect (OSTI)

    Yoon, Hyunjin; McDermott, Jason E.; Porwollik, Steffen; Mcclelland, Michael; Heffron, Fred

    2009-02-20

    Salmonella must respond to a myriad of environmental cues during infection of a mouse and express specific subsets of genes in a temporal and spatial manner to subvert the host defense mechanisms but these regulatory pathways are poorly established. To unravel how micro-environmental signals are processed and integrated into coordinated action, we constructed in-frame non-polar deletions of 84 regulators inferred to play a role in Salmonella typhimurium virulence and tested them in three virulence assays (intraperitoneal (i.p.), and intragastric (i.g.) infection in BALB/c mice, and persistence in SvJ129 mice). Overall 36 regulators were identified that were less virulent in at least one assay, and of those, 15 regulators were required for systemic mouse infection in an acute infection model. As a first step towards understanding the interplay between a pathogen and its host from a systems biology standpoint we focused on these 15 genes. Transcriptional profiles were obtained for each of these 15 regulators from strains grown under four different environmental conditions. These results as well as publicly available transcriptional profiles were analyzed using both network inference and cluster analysis algorithms. The analysis predicts a regulatory network in which all 15 regulators control a specific set of genes necessary for Salmonella to cause systemic infection. We tested the regulatory model by expressing a subset of the regulators in trans and monitoring transcription of 7 known virulence factors located within Salmonella pathogenicity island 2 (SPI-2). These experiments validated the regulatory model and showed that, for these 7 genes, the response regulator SsrB and the marR type regulator SlyA co-regulate in a regulatory cascade by integrating multiple signals.

  3. Wind/PV Generation for Frequency Regulation and Oscillation Damping in the Eastern Interconnection

    SciTech Connect (OSTI)

    Liu, Yong; Gracia, Jose R; Hadley, Stanton W; Liu, Yilu

    2013-12-01

    This report presents the control of renewable energy sources, including the variable-speed wind generators and solar photovoltaic (PV) generators, for frequency regulation and inter-area oscillation damping in the U.S. Eastern Interconnection (EI). In this report, based on the user-defined wind/PV generator electrical control model and the 16,000-bus Eastern Interconnection dynamic model, the additional controllers for frequency regulation and inter-area oscillation damping are developed and incorporated and the potential contributions of renewable energy sources to the EI system frequency regulation and inter-area oscillation damping are evaluated.

  4. Update on State Air Emission Regulations That Affect Electric Power Producers (released in AEO2005)

    Reports and Publications (EIA)

    2005-01-01

    Several states have recently enacted air emission regulations that will affect the electricity generation sector. The regulations are intended to improve air quality in the states and assist them in complying with the revised 1997 National Ambient Air Quality Standards (NAAQS) for ground-level ozone and fine particulates. The affected states include Connecticut, Massachusetts, Maine, Missouri, New Hampshire, New Jersey, New York, North Carolina, Oregon, Texas, and Washington. The regulations govern emissions of NOx, SO2, CO2, and mercury from power plants.

  5. The activity of CouR, a MarR family transcriptional regulator, is modulated

    Office of Scientific and Technical Information (OSTI)

    through a novel molecular mechanism (Journal Article) | SciTech Connect The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism Citation Details In-Document Search Title: The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism CouR, a MarR-type transcriptional repressor, regulates the cou genes, encoding p-hydroxycinnamate catabolism in the soil bacterium Rhodococcus jostii RHA1.

  6. 7th Workshop on Risk Informed Regulation and Safety Culture | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy 7th Workshop on Risk Informed Regulation and Safety Culture 7th Workshop on Risk Informed Regulation and Safety Culture May 19, 2015 - 5:51pm Addthis Sarah Lennon at the Qinshann Nuclear Power Plan Museum Sarah Lennon at the Qinshann Nuclear Power Plan Museum Sarah Lennon, Acting Director of the Office of Bilateral Cooperation attended the 7th Workshop on Risk Informed Regulation and Safety Culture held in Shenzhen, China, from March 23-27. More than 70 Chinese participants attended

  7. Final Guidance for Effective Use of Programmatic NEPA Review | Department

    Office of Environmental Management (EM)

    of Energy Effective Use of Programmatic NEPA Review Final Guidance for Effective Use of Programmatic NEPA Review On December 18, 2014, CEQ published final guidance that provides clarification on when and how Federal agencies can use programmatic NEPA reviews in accordance with the National Environmental Policy Act (NEPA) and the CEQ NEPA Regulations. Guidance on programmatic NEPA reviews has been requested by the agencies and attention on programmatic NEPA reviews has increased as agencies

  8. Industrial Energy Efficiency: Designing Effective State Programs for the

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Industrial Sector | Department of Energy Energy Efficiency: Designing Effective State Programs for the Industrial Sector Industrial Energy Efficiency: Designing Effective State Programs for the Industrial Sector This report provides state regulators, utilities, and other program administrators an overview of the spectrum of U.S. industrial energy efficiency (IEE) programs delivered by a variety of entities including utilities and program administrators. The report also assesses some of the

  9. Vermont Land Use: Essentials of Local Land Use Planning and Regulation...

    Open Energy Info (EERE)

    Use: Essentials of Local Land Use Planning and Regulation Jump to: navigation, search OpenEI Reference LibraryAdd to library PermittingRegulatory Guidance - GuideHandbook:...

  10. Examining the Variability of Wind Power Output in the Regulation Time Frame: Preprint

    SciTech Connect (OSTI)

    Hodge, B. M.; Shedd, S.; Florita, A.

    2012-08-01

    This work examines the distribution of changes in wind power for different time scales in the regulation time frame as well as the correlation of changes in power output for individual wind turbines in a wind plant.

  11. Title 18 CFR 292 Regulations Under Sections 201 and 210 of the...

    Open Energy Info (EERE)

    Act of 1978 With Regard to Small Power Production and Cogeneration, Forms under Title 18: Conservation of Power and Water Resources of the U.S. Code of Federal Regulations, current...

  12. http://www.regulations.gov/#!documentDetail;D=EERE-2014-BT-STD...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    www.regulations.govdocumentDetail;DEERE-2014-BT-STD-0031-0002 EERE-2014-BT-STD-0031-0002 spreadsheet Sheet "Summary Switching" - Before ME1 19421032v.1 http:...

  13. Isolated yeast promoter sequence and a method of regulated heterologous expression

    DOE Patents [OSTI]

    Gao, Johnway; Skeen, Rodney S.; Hooker, Brian S.; Anderson, Daniel B.

    2005-05-31

    The present invention provides the promoter clone discovery of a glucoamylase gene of a starch utilizing yeast strain Schwanniomyces castellii. The isolated glucoamylase promoter is an inducible promoter, which can regulate strong gene expression in starch culture medium.

  14. IDAPA 58.01.07 - Rules Regulating Underground Storage Tank Systems...

    Open Energy Info (EERE)

    7 - Rules Regulating Underground Storage Tank Systems Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: IDAPA 58.01.07 - Rules...

  15. Is Tritium Over-Regulated, Part 2 Should The TFG Support Higher...

    Office of Environmental Management (EM)

    Threshold Values? Presentation from the 33rd Tritium Focus Group Meeting held in Aiken, South Carolina on April 22-24, 2014. PDF icon Is Tritium Over-Regulated, Part 2...

  16. DOE specification: Valve-regulated type lead-acid storage batteries

    SciTech Connect (OSTI)

    1996-08-01

    This document contains a ``fill-in-the-blanks`` guide specification for procurement of sealed valve-regulated type lead-acid storage batteries, for uninterruptible power supply applications.

  17. FOIA 10CFR, Code of Federal Regulations for the Freedom of Information Act

    Broader source: Energy.gov [DOE]

    FOIA 10CFR, Code of Federal Regulations (CFR) for the Freedom of Information Act is 10 CFR 1004, as posted on the U.S. Department of Energy website.

  18. Title 16 USC 796 Regulation of the Development of Water Power...

    Open Energy Info (EERE)

    6 Regulation of the Development of Water Power and Resources Definitions Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Title 16...

  19. ORS 517.705 Exploration Permit Regulations for Mining and Mining...

    Open Energy Info (EERE)

    .705 Exploration Permit Regulations for Mining and Mining Claims Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: ORS 517.705...

  20. Structural insight into the regulation of MOF in the male-specific...

    Office of Scientific and Technical Information (OSTI)

    Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex Citation Details In-Document Search Title: Structural insight ...

  1. Department of Energy Finalizes Regulations to Increase Energy Efficiency in New Federal Buildings by 30%

    Office of Energy Efficiency and Renewable Energy (EERE)

    WASHINGTON DC - The U.S. Department of Energy (DOE) today announced it has established regulations that require new Federal buildings to achieve at least 30% greater energy efficiency over...

  2. Insulin like growth factor 2 regulation of aryl hydrocarbon receptor in MCF-7 breast cancer cells

    SciTech Connect (OSTI)

    Tomblin, Justin K.; Salisbury, Travis B.

    2014-01-17

    Highlights: IGF-2 stimulates concurrent increases in AHR and CCND1 expression. IGF-2 promotes the binding of AHR to the endogenous cyclin D1 promoter. AHR knockdown inhibits IGF-2 stimulated increases in CCND1 mRNA and protein. AHR knockdown inhibits IGF-2 stimulated increases in MCF-7 proliferation. -- Abstract: Insulin like growth factor (IGF)-1 and IGF-2 stimulate normal growth, development and breast cancer cell proliferation. Cyclin D1 (CCND1) promotes cell cycle by inhibiting retinoblastoma protein (RB1). The aryl hydrocarbon receptor (AHR) is a major xenobiotic receptor that also regulates cell cycle. The purpose of this study was to investigate whether IGF-2 promotes MCF-7 breast cancer proliferation by inducing AHR. Western blot and quantitative real time PCR (Q-PCR) analysis revealed that IGF-2 induced an approximately 2-fold increase (P < .001) in the expression of AHR and CCND1. Chromatin immunoprecipitation (ChIP), followed by Q-PCR indicated that IGF-2 promoted (P < .001) a 7-fold increase in AHR binding on the CCND1 promoter. AHR knockdown significantly (P < .001) inhibited IGF-2 stimulated increases in CCND1 mRNA and protein. AHR knockdown cells were less (P < .001) responsive to the proliferative effects of IGF-2 than control cells. Collectively, our findings have revealed a new regulatory mechanism by which IGF-2 induction of AHR promotes the expression of CCND1 and the proliferation of MCF-7 cells. This previously uncharacterized pathway could be important for the proliferation of IGF responsive cancer cells that also express AHR.

  3. Operon Formation is Driven by Co-Regulation and Not by Horizontal Gene

    Office of Scientific and Technical Information (OSTI)

    Transfer (Journal Article) | SciTech Connect Operon Formation is Driven by Co-Regulation and Not by Horizontal Gene Transfer Citation Details In-Document Search Title: Operon Formation is Driven by Co-Regulation and Not by Horizontal Gene Transfer Although operons are often subject to horizontal gene transfer (HGT), non-HGT genes are particularly likely to be in operons. To resolve this apparent discrepancy and to determine whether HGT is involved in operon formation, we examined the

  4. REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST:

    Office of Scientific and Technical Information (OSTI)

    PROPOSING A NEW STRATEGICALLY LOCATED AMERIFLUX TOWER SITE IN MISSOURI (Technical Report) | SciTech Connect Technical Report: REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW STRATEGICALLY LOCATED AMERIFLUX TOWER SITE IN MISSOURI Citation Details In-Document Search Title: REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW STRATEGICALLY LOCATED AMERIFLUX TOWER SITE IN MISSOURI by June 14, 2004, the MOFLUX site was fully

  5. Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle

    Office of Scientific and Technical Information (OSTI)

    cells (Journal Article) | SciTech Connect Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells Citation Details In-Document Search Title: Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells Authors: Chen, Xiaorui ; Ni, Fengyun ; Kondrashkina, Elena ; Ma, Jianpeng ; Wang, Qinghua [1] ; NWU) [2] ; Rice) [2] + Show Author Affiliations Baylor ( Publication Date: 2015-12-04 OSTI Identifier: 1228088 Resource Type: Journal Article Resource

  6. Financial Management of Money Received from Persons Who Have Allegedly Violated Department of Energy Regulations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1981-05-11

    To establish the policy, objectives, procedures, and responsibilities for the financial management of monies received from persons who have allegedly violated or who have violated the Department of Energy price and allocation regulations. Cancels HQ 2100.1, Financial Management of Money Received From Persons Who Have Allegedly Violated Department of Energy Regulations, dated 2-2-1981. Cancels HQ 2100.1. Canceled by DOE O 1321.140, dated 5-20-1994.

  7. Study of the impacts of regulations affecting the acceptance of integrated

    Office of Scientific and Technical Information (OSTI)

    community energy systems. Final report (Technical Report) | SciTech Connect Study of the impacts of regulations affecting the acceptance of integrated community energy systems. Final report Citation Details In-Document Search Title: Study of the impacts of regulations affecting the acceptance of integrated community energy systems. Final report × You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and

  8. Arrangement between the Office for Nuclear Regulation of Great Britain and

    Energy Savers [EERE]

    the United States Department of Energy for the Exchange of Information and Co-operation in the Area of Nuclear Safety Matters | Department of Energy Arrangement between the Office for Nuclear Regulation of Great Britain and the United States Department of Energy for the Exchange of Information and Co-operation in the Area of Nuclear Safety Matters Arrangement between the Office for Nuclear Regulation of Great Britain and the United States Department of Energy for the Exchange of Information

  9. Hazle Spindle, LLC Beacon Power 20 MW Flywheel Frequency Regulation Plant

    Office of Environmental Management (EM)

    Hazle Spindle, LLC Beacon Power 20 MW Flywheel Frequency Regulation Plant Project Description Beacon Power will design, build, and operate a utility-scale 20MW flywheel plant at the Humboldt Industrial Park in Hazle Township, Pennsylvania for the plant owner/operator, Hazle Spindle LLC The plant will provide frequency regulation services to grid operator PJM Interconnection. The Beacon Power technology uses flywheels to recycle energy from the grid in response to changes in demand and grid

  10. http://www.regulations.gov/#!documentDetail;D=EERE-2014-BT-STD-0031-0002

    Broader source: Energy.gov (indexed) [DOE]

    http://www.regulations.gov/#!documentDetail;D=EERE-2014-BT-STD-0031-0002 EERE-2014-BT-STD-0031-0002 spreadsheet Sheet "Summary Switching" - Before ME1 19421032v.1 http://www.regulations.gov/#!documentDetail;D=EERE-2014-BT-STD-0031-0002 EERE-2014-BT-STD-0031-0002 spreadsheet Sheet "Summary Switching" - Available for download now ME1 19421032v.1

  11. Exclusions and exemptions from RCRA hazardous waste regulation. RCRA Information Brief

    SciTech Connect (OSTI)

    Powers, J.

    1993-05-01

    The provisions in 40 CFR 261 establish which solid waste and are regulated under Subtitle C of the Resource Considered hazardous waste and are regulated under Subtitle C of the Resource Conservation and Recovery Act (RCRA). These provisions also exclude or exempt certain wastes from regulation. Wastes are excluded or exempted from coverage for a variety of reasons. The original RCRA legislation excluded a number of wastes that did not present a significant threat to human health or the environment or that were managed under other environmental programs. Other wastes were excluded by EPA to encourage their recycling or reuse as feedstocks in manufacturing processes. Some exclusions or exemptions serve to establish when a waste material becomes subject to regulation or when waste quantities are too minimal to be fully covered by the Federal hazardous waste regulatory program. As new regulations have caused the universe of RCRA generators and facilities to increase, the number of exclusions and exemptions have increased as well. This information Brief provides an overview of the types of waste and hazardous waste management units/facilities that may be excluded or exempted from regulation under the Federal hazardous waste (RCRA) Subtitle C) regulatory program. These wastes and units/facilities may or may not be excluded or exempted from coverage under authorized State RCRA programs.

  12. Reciprocal regulation of LXR? activity by ASXL1 and ASXL2 in lipogenesis

    SciTech Connect (OSTI)

    Park, Ui-Hyun; Seong, Mi-ran [Department of Bioscience and Biotechnology, Institute of Bioscience, BK21 Graduate Program, Sejong University, Seoul 143-747 (Korea, Republic of)] [Department of Bioscience and Biotechnology, Institute of Bioscience, BK21 Graduate Program, Sejong University, Seoul 143-747 (Korea, Republic of); Kim, Eun-Joo; Hur, Wonhee; Kim, Sung Woo [Department of Molecular Biology, BK21 Graduate Program, Dankook University, Gyeonggi-do 448-701 (Korea, Republic of)] [Department of Molecular Biology, BK21 Graduate Program, Dankook University, Gyeonggi-do 448-701 (Korea, Republic of); Yoon, Seung Kew [The Catholic University Liver Research Center and WHO Collaborating Center of Viral Hepatitis, The Catholic University, College of Medicine, Seoul 137-701 (Korea, Republic of)] [The Catholic University Liver Research Center and WHO Collaborating Center of Viral Hepatitis, The Catholic University, College of Medicine, Seoul 137-701 (Korea, Republic of); Um, Soo-Jong, E-mail: umsj@sejong.ac.kr [Department of Bioscience and Biotechnology, Institute of Bioscience, BK21 Graduate Program, Sejong University, Seoul 143-747 (Korea, Republic of)] [Department of Bioscience and Biotechnology, Institute of Bioscience, BK21 Graduate Program, Sejong University, Seoul 143-747 (Korea, Republic of)

    2014-01-10

    Highlights: ASXL1 and ASXL2 directly interact with ligand-bound LXR?. Ligand-induced LXR? activity is repressed by ASXL1 and activated by ASXL2. ASXL1 and ASXL2 bind to the LXRE of the LXR? target promoter. ASXL1 and ASXL2 reciprocally regulate lipogenesis in liver cells. -- Abstract: Liver X receptor alpha (LXR?), a member of the nuclear receptor superfamily, plays a pivotal role in hepatic cholesterol and lipid metabolism, regulating the expression of genes associated with hepatic lipogenesis. The additional sex comb-like (ASXL) family was postulated to regulate chromatin function. Here, we investigate the roles of ASXL1 and ASXL2 in regulating LXR? activity. We found that ASXL1 suppressed ligand-induced LXR? transcriptional activity, whereas ASXL2 increased LXR? activity through direct interaction in the presence of the ligand. Chromatin immunoprecipitation (ChIP) assays showed ligand-dependent recruitment of ASXLs to ABCA1 promoters, like LXR?. Knockdown studies indicated that ASXL1 inhibits, while ASXL2 increases, lipid accumulation in H4IIE cells, similar to their roles in transcriptional regulation. We also found that ASXL1 expression increases under fasting conditions, and decreases in insulin-treated H4IIE cells and the livers of high-fat diet-fed mice. Overall, these results support the reciprocal role of the ASXL family in lipid homeostasis through the opposite regulation of LXR?.

  13. Engine control techniques to account for fuel effects

    DOE Patents [OSTI]

    Kumar, Shankar; Frazier, Timothy R.; Stanton, Donald W.; Xu, Yi; Bunting, Bruce G.; Wolf, Leslie R.

    2014-08-26

    A technique for engine control to account for fuel effects including providing an internal combustion engine and a controller to regulate operation thereof, the engine being operable to combust a fuel to produce an exhaust gas; establishing a plurality of fuel property inputs; establishing a plurality of engine performance inputs; generating engine control information as a function of the fuel property inputs and the engine performance inputs; and accessing the engine control information with the controller to regulate at least one engine operating parameter.

  14. The role of integrated resource planning, environmental externalities, and anticipation of future regulation in compliance planning under the Clean Air Act Amendments of 1990

    SciTech Connect (OSTI)

    Bernow, S.; Biewald, B.; Wulfsberg, K.

    1993-07-01

    Utilities are developing sulfur dioxide (SO{sub 2}) emission compliance plans to meet limitations of the Clean Air Act Amendments of 1990 (CAAA). Compliance plans will have long-term effects on resource selection, fuel choice, and system dispatch. Use of integrated resource planning (IRP) is necessary to ensure compliance plans are consistent with the overall societal goals. In particular, environmental externalities must be integrated with the compliance planning process. The focus of the CAAA is on air pollution reduction, specifically acid gases and toxics, and attainment of National Ambient Air Quality Standards (NAAQS) for criteria pollutants. Title IV specifically focuses on sulfur dioxide with a national allowance trading system, while further regulation of toxics and nitrogen oxides is slated for additional study. Yet, compliance planning based narrowly upon today`s environmental regulations could fail to meet the broad goals of IRP if a larger array of environmental externalities is excluded from the analysis. Compliance planning must consider a broad range of environmental effects from energy production and use to (1) protect society`s long-term stake in environmental quality, and (2) ensure that today`s plans are rich enough to accommodate potential changes in regulation and national environmental goals. The explicit recognition of environmental effects, such as those associated with CO{sub 2} release, will result in prudent compliance plans that take advantage of current opportunities for pollution avoidance and have long-term viability in the face of regulatory change. By including such considerations, the mix of resources acquired and operated (supply and demand, existing and new, conventional and renewable, fuel type and fuel quality, pollution control, and dispatch protocols) will be robust and truly least-cost.

  15. Effect of graphite properties in thermal analysis of CHTR: A parametric study

    SciTech Connect (OSTI)

    Kaushik, Ankur; Basak, Abhishek; Dulera, I. V.; Vijayan, P. K.

    2013-06-12

    Compact High Temperature Reactor (CHTR) is a {sup 233}U-Thorium fuelled, lead-bismuth cooled reactor. The CHTR core mainly consists of graphite and beryllium oxide (BeO). The CHTR core consists of nineteen prismatic beryllium oxide (BeO) moderator blocks. These 19 blocks contain centrally located graphite fuel tubes. The BeO moderator blocks are surrounded by reflector blocks (partially graphite and partially BeO). The nuclear heat from the core is removed passively by natural circulation of the coolant between top and bottom plenums, upward through the fuel tubes and returning through the downcomer tubes at the periphery. The temperature gradient in fuel tubes, downcomer tubes and BeO is very high and therefore, to take care of the differential thermal expansion, gaps are provided in the core between the tubes and other core components. These gaps affect the heat transfer through the core in radial direction. In addition, there is a large variation in thermal properties of graphite which in turn affects the thermal behaviour of the core in various operating conditions. The fuel of CHTR is TRISO coated particle fuel. These particles are packed in with graphite powder as matrix and made into cylindrical compacts these compacts are packed in the bores of fuel tube. In this study, the effect of the thermal conductivity variation of the graphite on the temperature distribution of the core and density variation of the matrix graphite material in fuel compact on the maximum fuel kernel temperature is studied along with the overall role of graphite properties variation in heat transfer.

  16. Effect of rolling motion on critical heat flux for subcooled flow boiling in vertical tube

    SciTech Connect (OSTI)

    Hwang, J. S.; Park, I. U.; Park, M. Y.; Park, G. C.

    2012-07-01

    This paper presents defining characteristics of the critical heat flux (CHF) for the boiling of R-134a in vertical tube operation under rolling motion in marine reactor. It is important to predict CHF of marine reactor having the rolling motion in order to increase the safety of the reactor. Marine Reactor Moving Simulator (MARMS) tests are conducted to measure the critical heat flux using R-134a flowing upward in a uniformly heated vertical tube under rolling motion. MARMS was rotated by motor and mechanical power transmission gear. The CHF tests were performed in a 9.5 mm I.D. test section with heated length of 1 m. Mass fluxes range from 285 to 1300 kg m{sup -2}s{sup -1}, inlet subcooling from 3 to 38 deg. C and outlet pressures from 13 to 24 bar. Amplitudes of rolling range from 15 to 40 degrees and periods from 6 to 12 sec. To convert the test conditions of CHF test using R-134a in water, Katto's fluid-to-fluid modeling was used in present investigation. A CHF correlation is presented which accounts for the effects of pressure, mass flux, inlet subcooling and rolling angle over all conditions tested. Unlike existing transient CHF experiments, CHF ratio of certain mass flux and pressure are different in rolling motion. For the mass fluxes below 500 kg m{sup -2}s{sup -1} at 13, 16 (region of relative low mass flux), CHF ratio was decreased but was increased above that mass flux (region of relative high mass flux). Moreover, CHF tend to enhance in entire mass flux at 24 bar. (authors)

  17. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect (OSTI)

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. Neogenin was identified as the target gene of miR-18a. Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  18. Engineering of a novel Ca{sup 2+}-regulated kinesin molecular motor using a calmodulin dimer linker

    SciTech Connect (OSTI)

    Shishido, Hideki; Maruta, Shinsaku

    2012-06-29

    Highlights: Black-Right-Pointing-Pointer Engineered kinesin-M13 and calmodulin involving single cysteine were prepared. Black-Right-Pointing-Pointer CaM mutant was cross-linked to dimer by bifunctional thiol reactive reagent. Black-Right-Pointing-Pointer Kinesin-M13 was dimerized via CaM dimer in the presence of calcium. Black-Right-Pointing-Pointer Function of the engineered kinesin was regulated by a Ca{sup 2+}-calmodulin dimer linker. -- Abstract: The kinesin-microtubule system holds great promise as a molecular shuttle device within biochips. However, one current barrier is that such shuttles do not have 'on-off' control of their movement. Here we report the development of a novel molecular motor powered by an accelerator and brake system, using a kinesin monomer and a calmodulin (CaM) dimer. The kinesin monomer, K355, was fused with a CaM target peptide (M13 peptide) at the C-terminal part of the neck region (K355-M13). We also prepared CaM dimers using CaM mutants (Q3C), (R86C), or (A147C) and crosslinkers that react with cysteine residues. Following induction of K355-M13 dimerization with CaM dimers, we measured K355-M13 motility and found that it can be reversibly regulated in a Ca{sup 2+}-dependent manner. We also found that velocities of K355-M13 varied depending on the type and crosslink position of the CaM dimer used; crosslink length also had a moderate effect on motility. These results suggest Ca{sup 2+}-dependent dimerization of K355-M13 could be used as a novel molecular shuttle, equipped with an accelerator and brake system, for biochip applications.

  19. Identification of NDRG1-regulated genes associated with invasive potential in cervical and ovarian cancer cells

    SciTech Connect (OSTI)

    Zhao, Gang; Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin ; Chen, Jiawei; Deng, Yanqiu; Gao, Feng; Zhu, Jiwei; Feng, Zhenzhong; Lv, Xiuhong; Zhao, Zheng

    2011-04-29

    Highlights: {yields} NDRG1 was knockdown in cervical and ovarian cancer cell lines by shRNA technology. {yields} NDRG1 knockdown resulted in increased cell invasion activities. {yields} Ninety-six common deregulated genes in both cell lines were identified by cDNA microarray. {yields} Eleven common NDRG1-regulated genes might enhance cell invasive activity. {yields} Regulation of invasion by NDRG1 is an indirect and complicated process. -- Abstract: N-myc downstream regulated gene 1 (NDRG1) is an important gene regulating tumor invasion. In this study, shRNA technology was used to suppress NDRG1 expression in CaSki (a cervical cancer cell line) and HO-8910PM (an ovarian cancer cell line). In vitro assays showed that NDRG1 knockdown enhanced tumor cell adhesion, migration and invasion activities without affecting cell proliferation. cDNA microarray analysis revealed 96 deregulated genes with more than 2-fold changes in both cell lines after NDRG1 knockdown. Ten common upregulated genes (LPXN, DDR2, COL6A1, IL6, IL8, FYN, PTP4A3, PAPPA, ETV5 and CYGB) and one common downregulated gene (CLCA2) were considered to enhance tumor cell invasive activity. BisoGenet network analysis indicated that NDRG1 regulated these invasion effector genes/proteins in an indirect manner. Moreover, NDRG1 knockdown also reduced pro-invasion genes expression such as MMP7, TMPRSS4 and CTSK. These results suggest that regulation of invasion and metastasis by NDRG1 is a highly complicated process.

  20. NMR Characterization of C3H and HCT Down-Regulated Alfalfa Lignin (Journal

    Office of Scientific and Technical Information (OSTI)

    Article) | SciTech Connect NMR Characterization of C3H and HCT Down-Regulated Alfalfa Lignin Citation Details In-Document Search Title: NMR Characterization of C3H and HCT Down-Regulated Alfalfa Lignin Authors: Yunqiao,Pu ; Fang,Chen ; Angela,Ziebell ; Brian H.,Davison ; Arthur J.,Ragauskas ; , Publication Date: 2009-12-01 OSTI Identifier: 1151964 Resource Type: Journal Article Resource Relation: Journal Name: BioEnergy Research; Journal Volume: 2; Journal Issue: 4 Research Org: BioEnergy

  1. Fnr (EtrA) acts as a fine-tuning regulator of anaerobic metabolism in

    Office of Scientific and Technical Information (OSTI)

    Shewanella oneidensis MR-1 (Journal Article) | SciTech Connect Journal Article: Fnr (EtrA) acts as a fine-tuning regulator of anaerobic metabolism in Shewanella oneidensis MR-1 Citation Details In-Document Search Title: Fnr (EtrA) acts as a fine-tuning regulator of anaerobic metabolism in Shewanella oneidensis MR-1 EtrA in Shewanella oneidensis MR-1, a model organism for study of adaptation to varied redox niches, shares 73.6% and 50.8% amino acid sequence identity with the oxygen-sensing

  2. Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by

    Office of Scientific and Technical Information (OSTI)

    phosphorylating the CDK-inhibitor Rum1 (Journal Article) | SciTech Connect Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1 Citation Details In-Document Search Title: Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1 Highlights: ► Deletion of lkh1{sup +} made cells pass the G1/S phase faster than the wild type. ► Lkh1 can interact with a cyclin-dependent kinase inhibitor (CKI) Rum1. ►

  3. Structural insight into the regulation of MOF in the male-specific lethal

    Office of Scientific and Technical Information (OSTI)

    complex and the non-specific lethal complex (Journal Article) | SciTech Connect Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex Citation Details In-Document Search Title: Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex Authors: Huang, Jing ; Wan, Bingbing ; Wu, Lipeng ; Yang, Yuting ; Dou, Yali ; Lei, Ming [1] + Show Author Affiliations (Michigan-Med)

  4. Code of Federal Regulations Procedural Rules for DOE Nuclear Activities Part II

    Broader source: Energy.gov [DOE]

    The Department of Energy (DOE) is issuing procedural rules to be used in applying its substantive regulations and orders relating to nuclear safety. These procedural rules are intended to be an essential part of the framework through which DOE deals with its contractors, subcontractors, and suppliers to ensure its nuclear facilities are operated in a manner that protects public and worker safety and the environment. In particular, this part sets forth the procedures to implement the provisions of the Price- Anderson Amendments Act of 1988 (PAAA) which subjects DOE contractors to potential civil and criminal penalties for violations of DOE rules, regulations and orders relating to nuclear safety (DOE Nuclear Safety Requirements).

  5. Acquisition Regulation

    Office of Environmental Management (EM)

  6. Acquisition Regulation

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... formats and increasing transparency of business operations. ... These clauses in many cases have lacked key information ... the email specifying: * the text of a new clause or ...

  7. July 24, 2009, Visiting Speakers Program - The Next Generation of (Safety) Regulation for HRO's by Christopher Hart

    Office of Environmental Management (EM)

    Regulating HRO's: Next Generation July 24, 2009 Federal Aviation Administration 1 Federal Aviation Administration The Next Generation of (Safety) Regulation for HRO's Presentation to: HSS Visiting Speakers Program Name: Christopher A. Hart Date: July 24, 2009 Aviation Safety Experience - Conventional Wisdom: More vigorous regulation and enforcement will result in improved safety - Lesson Learned from Experience: There is a mishap rate plateau beyond which further improvement necessitates a more

  8. The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin

    SciTech Connect (OSTI)

    Song Jin; Jie Chunfa; Polk, Paula; Shridhar, Ravi; Clair, Timothy; Zhang, Jun; Yin, Lijia; Keppler, Daniel . E-mail: dkeppl@lsuhsc.edu

    2006-02-03

    We recently coined CST6 as a novel candidate tumor suppressor gene for breast cancer. CST6 indeed is expressed in the normal human breast epithelium, but little or not at all in breast carcinomas and breast cancer cell lines. Moreover, ectopic expression of CST6 in human breast cancer cells suppressed cell proliferation, migration, invasion, and orthotopic tumor growth. To obtain insights into the molecular mechanism by which CST6 exhibits its pleiotropic effects on tumor cells, we compared global gene expression profiles in mock- and CST6-transfected human MDA-MB-435S cells. Out of 12,625 transcript species, 61 showed altered expression. These included genes for extracellular matrix components, cytokines, kinases, and phosphatases, as well as several key transcription factors. TaqMan PCR assays were used to confirm the microarray data for 7 out of 11 genes. One down-regulated gene product, secreted autotaxin/lyso-phospholipase D, was of particular interest because its down-regulation by CST6 could explain most of CST6's effect on the breast cancer cells. This study thus provides First evidence that CST6 plays a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression.

  9. Petro-Safe '91 conference papers: Volume 1 (Regulations) and Volume 2 (Management responsibility and liability)

    SciTech Connect (OSTI)

    Not Available

    1991-01-01

    This is the second International Environmental and Safety Conference and Exhibition for the oil, gas and petrochemical industries. The conference provided a forum for the exchange of ideas on the regulations, management, and responsibility and liability concerning safety and the environment. Individual papers are processed separately for inclusion in the appropriate data bases.

  10. A compilation of current regulations, standards and guidelines in remote afterloading brachytherapy

    SciTech Connect (OSTI)

    Tortorelli, J.P.; Simion, G.P.; Kozlowski, S.D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1994-10-01

    Over a dozen government and professional organizations in the United States and Europe have issued regulations and guidance concerning quality management in the practice of remote afterloading brachytherapy. Information from the publications of these organizations was collected and collated for this report. This report provides the brachytherapy licensee access to a broad field of quality management information in a single, topically organized document.

  11. Technical guidance document for environmental requirements of commercial OTEC licensing regulations (15 CFR Part 981)

    SciTech Connect (OSTI)

    Not Available

    1981-09-01

    This document provides a potential OTEC applicant with the insights believed needed to satisfy the environmental information requirements of the regulations for licensing commercial OTEC facilities and plantships. This information should be used by applicants to define the site-specific details of the needed environmental assessment, and the details should then form a basis for pre-application consultations on the environmental requirements.

  12. Collaborative jurisdiction in the regulation of electric utilities: A new look at jurisdictional boundaries

    SciTech Connect (OSTI)

    1991-12-31

    This conference is one of several activities initiated by FERC, DOE and NARUC to improve the dialogue between Federal and State regulators and policymakers. I am pleased to be here to participate in this conference and to address, with you, electricity issues of truly national significance. I would like to commend Ashley Brown and the NARUC Electricity Committee for its foresight in devising a conference on these issues at this critical juncture in the regulation of the electric utility industry. I also would like to commend Chairman Allday and the FERC for their efforts to improve communication between Federal and State electricity regulators; both through FERC`s Public Conference on Electricity Issues that was held last June, and through the FERC/NARUC workshops that are scheduled to follow this conference. These collaborative efforts are important and necessary steps in addressing successfully the many issues facing the electric utility industry those who regulate it, and those who depend upon it - in other words, about everyone.

  13. Regulating greenhouse gas 'leakage': how California can evade the impending constitutional attacks

    SciTech Connect (OSTI)

    Brian H. Potts

    2006-06-15

    Federalist greenhouse gas regulation poses many constitutional pitfalls, and some fear that California's cap-and-trade and procurement cap proposals are vulnerable to constitutional challenge. An attack under the commerce clause seems to pose the biggest threat, but the author proposes an alternative that can eliminate this threat: market participation.

  14. Valuation of carbon capture and sequestration under Greenhouse gas regulations: CCS as an offsetting activity

    SciTech Connect (OSTI)

    Lokey, Elizabeth

    2009-08-15

    When carbon capture and sequestration is conducted by entities that are not regulated, it could be counted as an offset that is fungible in the market or sold to a voluntary market. This paper addresses the complications that arise in accounting for carbon capture and sequestration as an offset, and methodologies that exist for accounting for CCS in voluntary and compliance markets. (author)

  15. Massachusetts Model Zoning Bylaw for the Regulation of Solar Energy Systems

    Broader source: Energy.gov [DOE]

    This model bylaw was established to assist cities and towns throughout Massachusetts in establishing reasonable standards to facilitate the development of small, medium, and large-scale ground mounted or roof mounted solar systems. Municipalities are encouraged to use this bylaw to amend existing portions of local regulations with the help of municipal counsel.

  16. Cloning of a yeast alpha-amylase promoter and its regulated heterologous expression

    DOE Patents [OSTI]

    Gao, Johnway [Richland, WA; Skeen, Rodney S [Pendleton, OR; Hooker, Brian S [Kennewick, WA; Anderson, Daniel B [Pasco, WA

    2003-04-01

    The present invention provides the promoter clone discovery of an alpha-amylase gene of a starch utilizing yeast strain Schwanniomyces castellii. The isolated alpha-amylase promoter is an inducible promoter, which can regulate strong gene expression in starch culture medium.

  17. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

    SciTech Connect (OSTI)

    Fairman, James Wesley; Wijerathna, Sanath Ranjan; Ahmad, Md Faiz; Xu, Hai; Nakano, Ryo; Jha, Shalini; Prendergast, Jay; Welin, R. Martin; Flodin, Susanne; Roos, Annette; Nordlund, Pr; Li, Zongli; Walz, Thomas; Dealwis, Chris Godfrey

    2011-07-25

    Ribonucleotide reductase (RR) is an {alpha}{sub n}{beta}{sub n} (RR1-RR2) complex that maintains balanced dNTP pools by reducing NDPs to dNDPs. RR1 is the catalytic subunit, and RR2 houses the free radical required for catalysis. RR is allosterically regulated by its activator ATP and its inhibitor dATP, which regulate RR activity by inducing oligomerization of RR1. Here, we report the first X-ray structures of human RR1 bound to TTP alone, dATP alone, TTP-GDP, TTP-ATP, and TTP-dATP. These structures provide insights into regulation of RR by ATP or dATP. At physiological dATP concentrations, RR1 forms inactive hexamers. We determined the first X-ray structure of the RR1-dATP hexamer and used single-particle electron microscopy to visualize the {alpha}{sub 6}-{beta}{beta}'-dATP holocomplex. Site-directed mutagenesis and functional assays confirm that hexamerization is a prerequisite for inhibition by dATP. Our data indicate a mechanism for regulating RR activity by dATP-induced oligomerization.

  18. Structural Basis for Allosteric Regulation of Human Ribonucleotide Reductase by Nucleotide-induced Oligomerization

    SciTech Connect (OSTI)

    J Fairman; S Wijerathna; M Ahmad; H Xu; R nakano; S jha; J Prendergast; R Welin; S Flodin; et al.

    2011-12-31

    Ribonucleotide reductase (RR) is an {alpha}{sub n}{beta}{sub n} (RR1-RR2) complex that maintains balanced dNTP pools by reducing NDPs to dNDPs. RR1 is the catalytic subunit, and RR2 houses the free radical required for catalysis. RR is allosterically regulated by its activator ATP and its inhibitor dATP, which regulate RR activity by inducing oligomerization of RR1. Here, we report the first X-ray structures of human RR1 bound to TTP alone, dATP alone, TTP-GDP, TTP-ATP, and TTP-dATP. These structures provide insights into regulation of RR by ATP or dATP. At physiological dATP concentrations, RR1 forms inactive hexamers. We determined the first X-ray structure of the RR1-dATP hexamer and used single-particle electron microscopy to visualize the {alpha}{sub 6}-{beta}{beta}'-dATP holocomplex. Site-directed mutagenesis and functional assays confirm that hexamerization is a prerequisite for inhibition by dATP. Our data indicate a mechanism for regulating RR activity by dATP-induced oligomerization.

  19. A Regulator's Privacy Guide to Third-Party Data Access for Energy Efficiency

    Broader source: Energy.gov [DOE]

    A Regulator's Privacy Guide to Third-Party Data Access for Energy Efficiency summarizes approaches taken by states on privacy and security issues related to third-party access to customer data and provides guidance on policy options for providing access to customer data.

  20. Method for improving voltage regulation of batteries, particularly Li/FeS/sub 2/ thermal batteries

    DOE Patents [OSTI]

    Godshall, N.A.

    1986-06-10

    Batteries are improved, especially with respect to voltage regulation properties, by employing as anode and cathode compositions, those which fall in a thermodynamically invariant region of the metallurgical phase diagram of the combination of the constituent components. The invention is especially useful in the Li/FeS/sub 2/ system.