National Library of Energy BETA

Sample records for unicem usa il

  1. IL

    Office of Legacy Management (LM)

    :; / 2. ' b-:-"y .",...4 * .-.a 2 IL !< :. 34 --' -, ' ' < I ,-. g Tvo"l r . . .-i- :- " .1-. . . . . NC0 /L ' J,, ' ;.' , -_I( + ? CENTRAL FILES c -&' { ' c;$y ;;j*' E ,J): ' i' Z, 1; p -^ r-raL-r.nuzT".Fn., , ,..-y - -' -ie .". iJ.&:~e!ct.;;' sf ' ;;i_is ,trip ' JG,' go f-Jj;~ey~ 2123 -:s<j .-&;.z ;y1y rrc&ed recr!p!~-,da.a .b ,&.j.,& .:*3;.. F-Y ' __ ,,,.x+; PC l;ealti: :.2,.i CCI ;et y. tirlr.&g t;1c oy-er at ion c.f sei;a~xl

  2. Vestas USA | Open Energy Information

    Open Energy Info (EERE)

    USA Jump to: navigation, search Name: Vestas USA Place: Rolling Meadows, Illinois Zip: IL 60008-4030 Sector: Wind energy Product: Vestas Wind Systems American arm. References:...

  3. Offshore Wind Power USA

    Broader source: Energy.gov [DOE]

    The Offshore Wind Power USA conference provides the latest offshore wind market updates and forecasts.

  4. DOE - Office of Legacy Management -- Granite City IL Site - IL...

    Office of Legacy Management (LM)

    Contamination from rubbing off of oxidized uranium during handling. IL.28-3 IL.28-5 ... Aerial photograph of the Granite City, Illinois, Site IL.28-1 - DOE Memo; Wagoner to Price...

  5. IL FS Ecosmart Ltd | Open Energy Information

    Open Energy Info (EERE)

    Services Product: IL&FS Ecosmart Ltd., a subsidiary of the Infrastructure Leasing & Financial Services (IL&FS) Group, provides environmental services. References: IL&FS...

  6. AIR M A IL

    Office of Legacy Management (LM)

    MEMORlAL DRIVE AIR M A IL ._~ AtFx=b.-zf .7.-i- M r. s. .II. Gown -~ Gentlemen: Re: A.E.C. Contract No. We assume the weight of the 9-l/2" biscuits will:be 107'poutids approximately; i.e. 100 pounds of thorium per biscuit. A four biscuit charge is not feasible because of crucible dimensions, availability, etc. A three biscuit charge will, when molten, fill the proposed crucible half full. This condition is un- desirable because, due to the low heat of fusion of thorium and the

  7. Solar Unlimited USA | Open Energy Information

    Open Energy Info (EERE)

    USA Jump to: navigation, search Logo: Solar Unlimited USA Name: Solar Unlimited USA Address: 2353 Park Ave. Place: Cedar City, Utah Zip: 84721 Region: Rockies Area Sector: Solar...

  8. Geo processors USA | Open Energy Information

    Open Energy Info (EERE)

    processors USA Jump to: navigation, search Name: Geo-processors USA Place: California Zip: 91204 Sector: Carbon Product: California based Geo-procesors USA has developed an...

  9. Category:Chicago, IL | Open Energy Information

    Open Energy Info (EERE)

    74 KB SVHospital Chicago IL Commonwealth Edison Co.png SVHospital Chicago IL ... 68 KB SVLargeHotel Chicago IL Commonwealth Edison Co.png SVLargeHotel Chicago I... 75 KB...

  10. Category:Springfield, IL | Open Energy Information

    Open Energy Info (EERE)

    Springfield IL Commonwealth Edison Co.png SVQuickServiceRestaura... 75 KB SVFullServiceRestaurant Springfield IL Commonwealth Edison Co.png...

  11. LAPD Madison, Wisconsin USA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 th LAPD Madison, Wisconsin USA Sunday, 22 September 2013 Varsity Hall III, Union South 18:00-20:00 Reception and Registration Monday, 23 September 2013 Session I (8:30-12:30) Varsity Hall III, Union South Chairs: J-P. Booth, E. E. Scime Time Speaker Title Index 7:30-8:30 Continental Breakfast 8:30-8:45 D. J. Den Hartog Welcome 8:45-9:35 N. C. Luhmann, Jr. Millimeter Wave and THz Plasma Diagnostic Development AK (1) 9:35-10:00 L. Lin Laser-Based Faraday-Effect Measurement of Magnetic

  12. Arlington, VA 22209 USA

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    22209 USA Phone: (703) 522-0086 * Fax: (703) 522-0548 Email: governmentaffairs@hpba.org Web Site: www.hpba.org Before the Department of Energy Docket No. EERE-2014-BT-STD-0036 RIN 1904-AD35 Hearth, Patio, and Barbecue Association's Supplemental Request for Extension of Comment Period on Proposed Energy Conservation Standard for "Hearth Products" 80 Fed. Reg. 7082 (February 9, 2015) March 31, 2015 The Hearth, Patio & Barbecue Association ("HPBA") has already requested

  13. Worldwide Energy and Manufacturing USA Inc formerly Worldwide...

    Open Energy Info (EERE)

    and Manufacturing USA Inc formerly Worldwide Manufacturing USA Jump to: navigation, search Name: Worldwide Energy and Manufacturing USA Inc (formerly Worldwide Manufacturing USA)...

  14. Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex

    SciTech Connect (OSTI)

    Kennedy, M.K.; Park, L.S.

    1996-05-01

    IL-15 interacts with a heterotrimeric receptor that consists of the {beta} and {gamma} subunits of the IL-2 receptor (IL-2R) as well as a specific, high-affinity IL-15-binding subunit, which is designated IL-15R{alpha}. Since both the {beta} and the {gamma} subunits of the IL-2R are required for signaling by either IL-2 or IL-15, it is not surprising that these cytokines share many activities in vitro. However, the differential expression of these cytokines and the {alpha} chains of their receptors within various tissues and cell types suggests that IL-2 and IL-15 may perform at least partially distinct physiological functions. The production of IL-15 by macrophages, and possibly other cell types, in response to environmental stimuli and infectious agents suggests that IL-15 may play a role in protective immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. 56 refs.

  15. Scheuten Solar USA Inc | Open Energy Information

    Open Energy Info (EERE)

    USA Inc Jump to: navigation, search Name: Scheuten Solar USA, Inc. Place: Rancho Santa Margarita, California Zip: 92688 Sector: Solar Product: Manufacturer of Solar PV systems...

  16. Energy Pro USA | Open Energy Information

    Open Energy Info (EERE)

    Pro USA Jump to: navigation, search Name: Energy Pro USA Place: Chesterfield, Missouri Zip: MO 63017 Product: Energy Pro funds and implements demand side energy savings programs to...

  17. Windkraft Nord USA | Open Energy Information

    Open Energy Info (EERE)

    Nord USA Jump to: navigation, search Name: Windkraft Nord USA Place: San Diego, California Zip: 92122 Product: Subsidiary of WKN AG based in North America. References: Windkraft...

  18. Solar Millennium LLC USA | Open Energy Information

    Open Energy Info (EERE)

    LLC USA Jump to: navigation, search Name: Solar Millennium LLC (USA) Place: Berkeley, California Sector: Solar Product: California-based STEG power plant developer, parabolic...

  19. Coaltec Energy USA Inc | Open Energy Information

    Open Energy Info (EERE)

    Coaltec Energy USA Inc Jump to: navigation, search Name: Coaltec Energy USA, Inc. Place: Carterville, Illinois Zip: 62918 Sector: Biomass Product: Coaltec Energy provides energy...

  20. Think Solar USA | Open Energy Information

    Open Energy Info (EERE)

    Solar USA Jump to: navigation, search Name: Think Solar USA Product: Maker, installer and distributor of parabolic trough STEG power and hot water systems. References: Think Solar...

  1. Energy Optimizers USA | Open Energy Information

    Open Energy Info (EERE)

    Optimizers USA Jump to: navigation, search Name: Energy Optimizers USA Address: 6 S. 3rd Street Place: Tipp City, Ohio Zip: 45371 Sector: Biomass, Carbon, Geothermal energy,...

  2. AREA USA LLC | Open Energy Information

    Open Energy Info (EERE)

    AREA USA LLC Jump to: navigation, search Name: AREA USA LLC Place: Washington, DC Zip: 20004 Sector: Services Product: Washington, D.C.-based division of Fabiani & Company...

  3. Usina Santo Angelo USA | Open Energy Information

    Open Energy Info (EERE)

    Santo Angelo USA Jump to: navigation, search Name: Usina Santo Angelo (USA) Place: Pirajuba, Minas Gerais, Brazil Product: Minas Gerais-based ethanol and energy producer company....

  4. BROAD USA Inc | Open Energy Information

    Open Energy Info (EERE)

    BROAD USA Inc Jump to: navigation, search Name: BROAD USA, Inc Place: Hackensack, New Jersey Zip: 7601 Product: BROAD manufactures absorption chillers powered by clean and...

  5. Norvento USA LLC | Open Energy Information

    Open Energy Info (EERE)

    USA LLC Jump to: navigation, search Name: Norvento USA LLC Place: Boston, Massachusetts Product: Boston-based engineering consultancy and division of Norvento SA. Coordinates:...

  6. Sharp Electronics Corporation USA | Open Energy Information

    Open Energy Info (EERE)

    Electronics Corporation USA Jump to: navigation, search Name: Sharp Electronics Corporation (USA) Place: Huntington Beach, California Zip: 92647 Product: North American division of...

  7. IL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power ...

  8. Il.-'",.'

    Office of Legacy Management (LM)

    ... D&D STATUS REPORT NEW BRUNSWICK LABORATORY NEW JERSEY SITE R. A. Wynveen V. R. Veluri W. H. Smith M. J. Robinet H. J. Moe DECEMBER 1981 INDEX Text D&D ......

  9. Structural and Biophysical Studies of the Human IL-7/IL-7R[alpha] Complex

    SciTech Connect (OSTI)

    McElroy, Craig A.; Dohm, Julie A.; Walsh, Scott T.R.; (OSU); (UPENN)

    2009-03-06

    IL-7 and IL-7R{alpha} bind the {gamma}{sub c} receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7R{alpha} ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the {gamma}{sub c} family. IL-7 binds glycosylated IL-7R{alpha} 300-fold more tightly than unglycosylated IL-7R{alpha}, and the enhanced affinity is attributed primarily to an accelerated on rate. Structural comparison of IL-7 in complex to both forms of IL-7R{alpha} reveals that glycosylation does not participate directly in the binding interface. The SCID mutations of IL-7R{alpha} locate outside the binding interface with IL-7, suggesting that the expressed mutations cause protein folding defects in IL-7R{alpha}. The IL-7/IL-7R{alpha} structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases.

  10. DOE - Office of Legacy Management -- Fansteel Metallurgical Corp - IL 16

    Office of Legacy Management (LM)

    Fansteel Metallurgical Corp - IL 16 FUSRAP Considered Sites Site: Fansteel Metallurgical Corp. (IL.16 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Chicago , Illinois IL.16-1 Evaluation Year: 1987 IL.16-3 Site Operations: Sole producer and supplier of tantalum and columbium metals to the MED. IL.16-1 IL.16-3 Site Disposition: Eliminated - No radioactive materials handled at this site IL.16-2 IL.16-3 Radioactive Materials

  11. Absolute Energy USA | Open Energy Information

    Open Energy Info (EERE)

    USA Jump to: navigation, search Name: Absolute Energy (USA) Place: St. Ansgar, Iowa Zip: 50472 Product: Absolute Energy has built a 100 million gallon per year ethanol plant on the...

  12. PNE Wind USA Inc | Open Energy Information

    Open Energy Info (EERE)

    USA Inc Jump to: navigation, search Name: PNE Wind USA Inc Place: Chicago, Illinois Zip: 60601 Sector: Wind energy Product: Chicago-based subsidiary of wind farm project developer,...

  13. Hisense USA: Order (2010-CE-1211)

    Office of Energy Efficiency and Renewable Energy (EERE)

    DOE issued an Order after entering into a Compromise Agreement with Hisense USA Corp. after finding Hisense USA had failed to certify that certain models of residential refrigerators, refrigerator-freezers, and freezers comply with the applicable energy conservation standards.

  14. OTB USA Inc | Open Energy Information

    Open Energy Info (EERE)

    OTB USA Inc Jump to: navigation, search Name: OTB USA Inc Address: 1871 Suffolk Rd. Place: Columbus, Ohio Zip: 43221 Sector: Solar Product: Other:Capital Equipment Phone Number:...

  15. USA Manufacturing: Order (2013-CE-5336)

    Broader source: Energy.gov [DOE]

    DOE ordered USA Manufacturing to pay a $8,000 civil penalty after finding USA Manufacturing had failed to certify that certain models of walk-in cooler and freezer components comply with the applicable energy conservation standards.

  16. FRONIUS USA LLC | Open Energy Information

    Open Energy Info (EERE)

    48116 USA, Michigan Sector: Solar Product: Focused on welding machines and solar inverters. References: FRONIUS USA LLC1 This article is a stub. You can help OpenEI by...

  17. Euro Chef USA: Order (2014-CE-23004)

    Broader source: Energy.gov [DOE]

    DOE ordered Euro Chef USA Inc. to pay a $8,000 civil penalty after finding Euro Chef USA had failed to certify that certain models of cooking products comply with the applicable energy conservation standards.

  18. DOE - Office of Legacy Management -- Kankakee Ordnance Plant - IL 32

    Office of Legacy Management (LM)

    Kankakee Ordnance Plant - IL 32 FUSRAP Considered Sites Site: KANKAKEE ORDNANCE PLANT (IL.32 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Kankakee , Illinois IL.32-1 Evaluation Year: 1991 IL.32-1 Site Operations: Kankakee Ordnance Plant was cited as a possible location for the disposal of radioactive waste material. There is no indication that any radioactive waste was brought to Kankakee. IL.32-1 IL.32-2 Site Disposition:

  19. DOE - Office of Legacy Management -- Swenson Evaporator Co - IL 23

    Office of Legacy Management (LM)

    Swenson Evaporator Co - IL 23 FUSRAP Considered Sites Site: SWENSON EVAPORATOR CO. (IL.23 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Harvey , Illinois IL.23-1 Evaluation Year: 1987 IL.23-1 Site Operations: Scheduled a raffinate spray drying test that was later cancelled. IL.23-1 Site Disposition: Eliminated - No indication that radioactive materials were handled at this site IL.23-1 Radioactive Materials Handled: None

  20. DOE - Office of Legacy Management -- Vapofier Corp - IL 25

    Office of Legacy Management (LM)

    Vapofier Corp - IL 25 FUSRAP Considered Sites Site: Vapofier Corp. (IL.25) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: Therm-A-Shield Co. IL.25-1 Location: 11957 Vincennes Avenue , Blue Island , Illinois IL.25-2 Evaluation Year: 1990 IL.25-1 Site Operations: Vapofier Corporation was a subcontractor to the MED during a nine month period in 1944. There is no indication that radioactive materials were handled. IL.25-1 Site Disposition:

  1. DOE - Office of Legacy Management -- Podbeilniac Corp - IL 22

    Office of Legacy Management (LM)

    Podbeilniac Corp - IL 22 FUSRAP Considered Sites Site: PODBEILNIAC CORP. (IL.22) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Chicago , Illinois IL.22-1 Evaluation Year: 1990 IL.22-2 Site Operations: MED used equipment for a uranium extraction experiment in 1957. IL.22-1 Site Disposition: Eliminated - Potential for contamination considered remote due to limited scope of activities performed at the site IL.22-2 IL.22-3 IL.22-4

  2. H2USA | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    USA H2USA In 2013 many auto manufacturers announced fuel cell electric vehicle (FCEV) commercialization plans; Toyota, Hyundai, General Motors, Honda, Mercedes/Daimler, and others have committed to putting FCEVs on the road, some as early as the 2015-2017 timeframe. While the cars are coming, hydrogen infrastructure remains the greatest challenge to commercialization of FCEVs. To address this challenge, in 2013 DOE, along with automakers and other key stakeholders, launched H2USA, a new

  3. DOE - Office of Legacy Management -- Armour Research Foundation - IL 17

    Office of Legacy Management (LM)

    Research Foundation - IL 17 FUSRAP Considered Sites Site: Armour Research Foundation of the Illinois Institute of Technology (IL.17 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: Illinois Institute of Technology IL.17-1 Location: Technological Center, 10 West 35th Street , Chicago , Illinois IL.17-1 Evaluation Year: 1985 IL.17-3 Site Operations: Facility operated a research reactor and conducted associated research for the AEC beginning in

  4. DOE - Office of Legacy Management -- Blockson Chemical Co - IL 07

    Office of Legacy Management (LM)

    Blockson Chemical Co - IL 07 FUSRAP Considered Sites Site: Blockson Chemical Co. (IL.07) Eliminated from consideration under FUSRAP - Referred to US EPA Region V and the State of Illinios Designated Name: Not Designated Alternate Name: Olin Corporation IL.07-1 Location: Patterson Road , Joliet , Illinois IL.07-2 Evaluation Year: 1985 IL.07-1 Site Operations: Process development studies and pilot plant testing of uranium recovery from phosphoric acid during the 1950s. Site Disposition: Eliminated

  5. DOE - Office of Legacy Management -- Kaiser Aluminum Corp - IL 19

    Office of Legacy Management (LM)

    Kaiser Aluminum Corp - IL 19 FUSRAP Considered Sites Site: KAISER ALUMINUM CORP. (IL.19 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Dolton , Illinois IL.19-2 Evaluation Year: 1987 IL.19-2 Site Operations: Performed limited duration work extruding uranium billets into three CP-5 fuel elements, circa 1959. IL.19-2 Site Disposition: Eliminated - Potential for contamination considered remote due to limited scope of activities

  6. DOE - Office of Legacy Management -- Precision Extrusion Co - IL 20

    Office of Legacy Management (LM)

    Precision Extrusion Co - IL 20 FUSRAP Considered Sites Site: PRECISION EXTRUSION CO. (IL.20) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 720 East Green Avenue , Bensenville , Illinois IL.20-1 Evaluation Year: 1987 IL.20-2 Site Operations: 1956-1959, metal fabrication - extruded uranium billets. IL.20-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited quantities of materials handled

  7. Sol-Up USA, LLC | Open Energy Information

    Open Energy Info (EERE)

    Sol-Up USA, LLC Jump to: navigation, search Logo: Sol-Up USA, LLC Name: Sol-Up USA, LLC Address: 3355 West Spring Mountain Road, Suite 3 Place: Las Vegas, NV Zip: 89102 Sector:...

  8. China Solar Clean Energy Solutions Inc formerly Deli Solar USA...

    Open Energy Info (EERE)

    Inc formerly Deli Solar USA Inc Jump to: navigation, search Name: China Solar & Clean Energy Solutions Inc ( formerly Deli Solar (USA) Inc) Place: Connecticut Zip: 6039 Sector:...

  9. Mitsubishi Electric and Electronics USA Inc | Open Energy Information

    Open Energy Info (EERE)

    and Electronics USA Inc Jump to: navigation, search Name: Mitsubishi Electric and Electronics USA Inc Place: Cypress, California Zip: 90630 Sector: Solar Product: Markets and...

  10. E ON Climate Renewables North America formerly Airtricity USA...

    Open Energy Info (EERE)

    Climate Renewables North America formerly Airtricity USA Jump to: navigation, search Name: E.ON Climate & Renewables North America (formerly Airtricity USA) Place: Chicago,...

  11. FRV USA formerly Fotowatio Renewable Ventures LLC | Open Energy...

    Open Energy Info (EERE)

    USA formerly Fotowatio Renewable Ventures LLC Jump to: navigation, search Name: FRV USA (formerly Fotowatio Renewable Ventures LLC) Place: San Francisco, California Zip: 94104...

  12. Calyxo USA Solar Fields LLC | Open Energy Information

    Open Energy Info (EERE)

    USA Solar Fields LLC Jump to: navigation, search Name: Calyxo USA (Solar Fields LLC) Place: Perrysburg, Ohio Zip: 43551 Sector: Solar Product: Producer of cadmium telluride...

  13. USA Science and Engineering Festival: Inspiring and Educating...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    USA Science and Engineering Festival: Inspiring and Educating the Clean Energy Workforce of Tomorrow USA Science and Engineering Festival: Inspiring and Educating the Clean Energy...

  14. Acciona Wind Energy USA LLC | Open Energy Information

    Open Energy Info (EERE)

    USA LLC Jump to: navigation, search Name: Acciona Wind Energy USA LLC Place: Chicago, Illinois Zip: 60631 Sector: Wind energy Product: US wind farms developer subsidiary of Acciona...

  15. MOU signed between CIAE and Jefferson National Lab, USA. (China...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MOU signed between CIAE and Jefferson National Lab, USA. (China Nuclear Industry News, ... of Jefferson National Lab, USA visited the China Institute of Atomic Energy (CIAE). ...

  16. Macquarie Funds Management USA Inc | Open Energy Information

    Open Energy Info (EERE)

    Macquarie Funds Management USA Inc Jump to: navigation, search Name: Macquarie Funds Management (USA) Inc. Place: Carlsbad, California Zip: 92008 Product: Fund of funds arm of...

  17. MOU signed between CIAE and Jefferson National Lab, USA. (China...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    https:www.jlab.orgnewsarticlesmou-signed-between-cia...-and-jefferson-national-lab-usa-china-nuclear-industry-news-ge... ... USA visited the China Institute of Atomic Energy (CIAE). ...

  18. Naturener USA LLC formerly Great Plains Wind Energy | Open Energy...

    Open Energy Info (EERE)

    USA LLC formerly Great Plains Wind Energy Jump to: navigation, search Name: Naturener USA, LLC (formerly Great Plains Wind & Energy) Place: San Francisco, California Zip: 94111...

  19. HERA USA Inc formerly Ergenics Inc | Open Energy Information

    Open Energy Info (EERE)

    USA Inc (formerly Ergenics Inc) Place: Ringwood, New Jersey Zip: 7456 Sector: Hydro, Hydrogen Product: Ergenics is a USA based company with extensive experience in the development...

  20. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    SciTech Connect (OSTI)

    Forward, Nicholas A.; Conrad, David M.; Power Coombs, Melanie R.; Doucette, Carolyn D.; Furlong, Suzanne J.; Lin, Tong-Jun; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia ; Hoskin, David W.

    2011-04-22

    Highlights: {yields} Curcumin inhibits CD4{sup +} T-lymphocyte proliferation. {yields} Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4{sup +} T-lymphocytes. {yields} Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. {yields} IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4{sup +} T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 ({alpha} chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca{sup 2+} release to inhibit I{kappa}B phosphorylation, which is required for nuclear translocation of the transcription factor NF{kappa}B. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4{sup +}CD25{sup +} regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  1. DOE - Office of Legacy Management -- Heavy Minerals Inc - IL 14

    Office of Legacy Management (LM)

    Heavy Minerals Inc - IL 14 FUSRAP Considered Sites Site: Heavy Minerals, Inc. ( IL.14 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: W.R. Grace Company IL.14-1 Location: 836 South Michigan Avenue , Chicago , Illinois IL.14-2 Evaluation Year: 1990 IL.14-1 Site Operations: Submitted a proposal to supply thorium hydroxide to the AEC; no indication that the bid was accepted. IL.14-2 Site Disposition: Eliminated - No indication of work done with

  2. Solar Systems USA | Open Energy Information

    Open Energy Info (EERE)

    up":"","inlineLabel":"","visitedicon":"" Hide Map References: Solar Systems USA Online Solar Panel Retailer1 This article is a stub. You can help OpenEI by expanding it. Solar...

  3. Hisense USA: Proposed Penalty (2010-CE-1211)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that Hisense USA Corp. failed to certify a variety of residential refrigerators, refrigerator-freezers, and freezers as compliant with the applicable energy conservation standards.

  4. USA Manufacturing: Proposed Penalty (2013-CE-5336)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that USA Manufacturing failed to certify walk-in cooler or freezer components as compliant with the energy conservation standards.

  5. DOE - Office of Legacy Management -- Chicago North IL Site -...

    Office of Legacy Management (LM)

    IL.05-1 - DOE Letter; Whitman to Wallo; Subject: Authority decisions regarding several sites; October 28, 1985 IL.05-2 - DOE Letter; DeLaney to Holesinger; Subject: Radiological ...

  6. DOE - Office of Legacy Management -- Rock Island Arsenal - IL...

    Office of Legacy Management (LM)

    to DOD Designated Name: Not Designated Alternate Name: None Location: Rock Island , Illinois IL.09-1 Evaluation Year: 1987 IL.09-2 Site Operations: Site located on a DOD ...

  7. Il Woong Jung | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Il Woong Jung Assistant Scientist Education Ph.D., Electrical Engineering, Stanford University Research Summary Research interests are in photonic applications for micro- and nano-mechanical devices. Current research focuses on the manipulation of light-matter interaction at the nanoscale, specifically using micro- and nano-mechanical devices to control the optical properties of photonic nanostructures. The aim is to integrate optical nanostructures and nanomechanical devices to create novel

  8. DOE - Office of Legacy Management -- International Register - IL 15

    Office of Legacy Management (LM)

    Register - IL 15 Site ID (CSD Index Number): IL.15 Site Name: International Register Site Summary: Site Link: External Site Link: Alternate Name(s): Intermatic Inc. Alternate Name Documents: Location: Chicago, Illinois Location Documents: IL.15-1 Historical Operations (describe contaminants): Limited testing of centerless grinding techniques for uranium metal for the AEC. Historical Operations Documents: IL.15-2 Eligibility Determination: Eliminated - Potential for contamination considered

  9. LES' URENCO-USA Facility | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    LES' URENCO-USA Facility LES' URENCO-USA Facility PowerPoint slides on LES's URENCO-USA Facility LES' URENCO-USA Facility (581.43 KB) More Documents & Publications 2014 Review of the Potential Impact of DOE Excess Uranium Inventory On the Commercial Markets Memorandum Memorializing Ex Parte Communication Report on the Effect the Low Enriched Uranium Delivered Under the Highly Enriched Uranium Agreement Between the USA and the Russian Federation has on the Domestic Uranium Mining, Conversion,

  10. DOE - Office of Legacy Management -- Crane Co - IL 13

    Office of Legacy Management (LM)

    Crane Co - IL 13 FUSRAP Considered Sites Site: Crane Co. (IL.13 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Chicago , Illinois IL.13-2 Evaluation Year: 1987 IL.13-2 Site Operations: MED activities during late-1940s to early/mid-1950s included the development of valves and possibly the use of test quantities of normal uranium in the development process. IL.13-4 Site Disposition: Eliminated - Potential for contamination remote due to

  11. DOE - Office of Legacy Management -- GSA 39th Street Warehouse - IL 02

    Office of Legacy Management (LM)

    GSA 39th Street Warehouse - IL 02 FUSRAP Considered Sites Site: GSA 39TH STREET WAREHOUSE (IL.02 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 1716 West Pershing Road , Chicago , Illinois IL.02-1 Evaluation Year: 1985 IL.02-2 IL.02-3 Site Operations: Stored radioactive materials. IL.02-1 IL.02-2 Site Disposition: Eliminated - Radiation levels below criteria IL.02-1 Radioactive Materials Handled: Yes Primary Radioactive Materials

  12. Ultra Soy of America DBA USA Biofuels | Open Energy Information

    Open Energy Info (EERE)

    Ultra Soy of America DBA USA Biofuels Jump to: navigation, search Name: Ultra Soy of America (DBA USA Biofuels) Place: Fort Wayne, Indiana Zip: 46898 Sector: Biofuels Product: An...

  13. DuraLamp USA: Order (2010-CE-0912)

    Broader source: Energy.gov [DOE]

    DOE ordered DuraLamp USA, Inc. to pay a $2,500 civil penalty after finding DuraLamp USA had failed to certify that model PAR 30, an incandescent reflector lamp, complies with the applicable energy conservation standards.

  14. Smeg USA: Order (2011-CE-14/1909)

    Office of Energy Efficiency and Renewable Energy (EERE)

    DOE ordered Smeg USA, Inc. to pay a $6,000 civil penalty after finding Smeg USA had failed to certify that certain models of dishwashers and refrigerators comply with the applicable energy conservation standards.

  15. DOE - Office of Legacy Management -- Madison - IL 26

    Office of Legacy Management (LM)

    Historical Operations: Conducted experimental work in natural uranium metal extrusion. ... 1992 IL.26-2 - DOE Memorandum; Wagoner to Price (OR); Authorization for Remedial Action at ...

  16. EA-332 Nexen Marketing U.S.A. Inc. | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Nexen Marketing U.S.A. Inc. EA-332 Nexen Marketing U.S.A. Inc. Order authorizing Nexen Marketing U.S.A. Inc. to export electric energy to Canada EA-332 Nexen Marketing U.S.A. Inc. ...

  17. DOE - Office of Legacy Management -- American Machine and Metals Inc - IL

    Office of Legacy Management (LM)

    24 Metals Inc - IL 24 FUSRAP Considered Sites Site: American Machine and Metals Inc (IL.24 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: E. Moline , Illinois IL.24-1 Evaluation Year: 1994 IL.24-2 IL.24-3 Site Operations: Tested process for dewatering green salt by centrifugation. IL.24-1 IL.24-2 Site Disposition: Eliminated - Potential for contamination considered remote due to limited amount of radioactive materials handled

  18. DOE - Office of Legacy Management -- Lindsay Light and Chemical Co - IL 10

    Office of Legacy Management (LM)

    Lindsay Light and Chemical Co - IL 10 FUSRAP Considered Sites Site: LINDSAY LIGHT AND CHEMICAL CO. ( IL.10 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: West Chicago , Illinois IL.10-3 Evaluation Year: 1995 IL.10-4 Site Operations: Processed thorium ores - chiefly monazite sands - for thorium and rare earth metals. IL.10-1 IL.10-2 Site Disposition: Eliminated - No Authority - NRC licensed operation IL.10-4 Radioactive Materials

  19. DOE Analysis Related to H2USA | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Analysis Related to H2USA DOE Analysis Related to H2USA Download presentation slides from the DOE Fuel Cell Technologies Office webinar "DOE Analysis Related to H2USA" held on July 24, 2013. DOE Analysis Related to H2USA Webinar Slides (4.8 MB) More Documents & Publications National Fuel Cell and Hydrogen Energy Overview: Total Energy USA 2012 Fuel Cell Technologies Program Overview: 2012 DOE Polymer and Composite Materials Meetings Hydrogen and Fuel Cells Program Overview: 2014

  20. DOE - Office of Legacy Management -- W E Pratt Manufacturing Co - IL 12

    Office of Legacy Management (LM)

    E Pratt Manufacturing Co - IL 12 FUSRAP Considered Sites Site: W.E. PRATT MANUFACTURING CO. (IL.12) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: William E. Pratt Manufacturing Co. Klassing Handbrake Company IL.12-1 IL.12-2 Location: 18 Henderson Street , Joliet , Illinois IL.12-3 Evaluation Year: 1990 IL.12-4 IL.12-5 Site Operations: Performed metal fabrication tasks (machining and grinding). IL.12-1 IL.12-4 Site Disposition: Eliminated - Radiation

  1. Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation

    SciTech Connect (OSTI)

    Zuniga-Pfluecker, J.C.K.; Kruisbeek, A.M. )

    1990-05-15

    Sublethally irradiated mice undergo thymic regeneration which follows a phenotypic pattern of events similar to that observed during normal fetal development. Thymic regeneration after irradiation is the product of a limited pool of intrathymic radioresistant stem cells undergoing simultaneous differentiation. We show that in this model of T cell development, thymic regeneration follows a pathway in which the IL-2R is transiently expressed on CD4-/CD8- cells. IL-2R expression occurred during the exponential growth period of thymic regeneration, and IL-2R blocking prevented this explosive growth. Flow cytometry analysis revealed that the IL-2R blockade affected primarily the development of the immature CD3-/CD4-/CD8- (triple negative) cells and their ability to generate CD3+/CD4+/CD8+ or CD3+/CD4+/CD8- and CD3+/CD4-/CD8+ thymocytes. Thus, our findings demonstrate that blocking of the IL-2R resulted in an arrest in proliferation and differentiation by intrathymic radioresistant stem cells, indicating that the IL-2/IL-2R pathway is necessary for the expansion of immature triple negative T cells.

  2. DOE - Office of Legacy Management -- Great Lakes Carbon Corp - IL 21

    Office of Legacy Management (LM)

    Great Lakes Carbon Corp - IL 21 FUSRAP Considered Sites Site: GREAT LAKES CARBON CORP. ( IL.21 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 333 North Michigan Avenue , Chicago , Illinois IL.21-1 Evaluation Year: 1987 IL.21-1 Site Operations: Facility performed a limited amount of nuclear fuel fabrication in the 1950s. Facility also developed graphite production under an AEC contract. IL.21-1 IL.21-3 Site Disposition:

  3. DOE - Office of Legacy Management -- Chicago South IL Site -...

    Office of Legacy Management (LM)

    This site is managed by the U.S. Department of Energy Office of Legacy Management. IL.06-1 - DOE Memorandum; Coffman to LaGrone; Subject: Designation of the University of Chicago ...

  4. USA Biomass Power Producers Alliance | Open Energy Information

    Open Energy Info (EERE)

    Biomass Power Producers Alliance Jump to: navigation, search Name: USA Biomass Power Producers Alliance Place: Sacramento, California Sector: Biomass Product: National trade...

  5. International Energy Services USA Inc | Open Energy Information

    Open Energy Info (EERE)

    Inc Jump to: navigation, search Name: International Energy Services USA Inc Place: Washington, Washington, DC Sector: Renewable Energy Product: Owns various renewable energy...

  6. File:INL-geothermal-west-usa.pdf | Open Energy Information

    Open Energy Info (EERE)

    INL-geothermal-west-usa.pdf Jump to: navigation, search File File history File usage Western United States Geothermal Resources Size of this preview: 653 599 pixels. Other...

  7. Euro Chef USA: Proposed Penalty (2014-CE-23004)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that Euro Chef USA Inc. failed to certify cooking products as compliant with the applicable energy conservation standards.

  8. Ormat Technologies Inc. North Brawley, California USA | Open...

    Open Energy Info (EERE)

    Not Provided DOI Not Provided Check for DOI availability: http:crossref.org Online Internet link for Ormat Technologies Inc. North Brawley, California USA Citation Ormat...

  9. Origin State>> CA ID ID IL IL KY NM NM NV NY OH TN TN TN, WA,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    IL IL KY NM NM NV NY OH TN TN TN, WA, CA TN TN TN TN Total Shipments by Route Lawrence Livermore National Laboratory Batelle Energy Alliance Idaho National Laboratory Energx Argonne National Laboratory Argonne National Laboratory Paducah Gaseous Diffusion Plant Sandia National Laboratory Los Alamos National Laboratory National Security Technologies West Valley Environmental Services Portsmouth Gaseous Diffusion Plant Duratek/Energy Solutions Babcox & Wilcox Technical Services Y-12 Plant

  10. Interleukin-2 (IL-2) dependent expression of biologically relevant IL-2 receptors: uncoupling of anti-T3 induced receptor expression with cyclosporin

    SciTech Connect (OSTI)

    Gitter, A.B.D.; Labus, J.M.; Butler, L.D.

    1986-03-01

    Human peripheral blood T cell expression of IL-2 receptors (IL-2R), detected by both immunocytofluorometry and /sup 125/I-IL-2 binding, was studied using lymphocytes stimulated with monoclonal anti-T3 antibodies (Leu-4, OKT3). Lymphocytes, isolated from healthy individuals, were prescreened and classified as Leu-4 responders or non-responders according to 72 h /sup 3/H-thymidine incorporation experiments. Leu-4 non-responder lymphocytes, though capable of normal IL-2R expression and IL-2 secretion when cultured with OKT3 (IgG2a), expressed little to no IL-2R nor secreted IL-2 when stimulated with Leu-4 (IgG1). In addition, the amount of IL-2 secreted by Leu-4 stimulated, Leu-4 responder cells, was one-third- to one-fifth of that detected when OKT3 was used as the stimulant. The addition of recombinant IL-2 (rIL-2) to a Leu-4 stimulated, Leu-4 non-responder lymphocyte culture, resulted in the expression of IL-2R and cellular proliferation, indicating that IL-2 upregulated its biologically relevant receptor. As expected, cyclosporin-A (CSA) inhibited the secretion of IL-2 and subsequent proliferation of Leu-4 stimulated, Leu-4 responder cells. Unexpectedly, however, the expression of IL-2R was also blocked. Exogenous rIL-2 partially reversed the effect of CSA on IL-2R expression and proliferation. The results indicate that IL-2 may provide an additional, required signal for optimal IL-2R expression.

  11. ENG-Canada-USA Government Procurement (clean 11 Feb 2010 printed...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ENG-Canada-USA Government Procurement (clean 11 Feb 2010 printed) ENG-Canada-USA Government Procurement (clean 11 Feb 2010 printed) ENG-Canada-USA Government Procurement (clean 11 ...

  12. EA-332-A Nexen Marketing U.S.A. Inc. | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    -A Nexen Marketing U.S.A. Inc. EA-332-A Nexen Marketing U.S.A. Inc. Order authorizing Nexen Marketing U.S.A. Inc. to export electric energy to Canada EA-332-A Nexen Marketing ...

  13. Reply Comments of T-Mobile USA, Inc. | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    T-Mobile USA, Inc. Reply Comments of T-Mobile USA, Inc. T-Mobile USA, Inc. ("T-Mobile") hereby submits these reply comments in response to the above-captioned Request for ...

  14. Deputy Secretary Daniel Poneman USA Today Op-Ed September 13...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Deputy Secretary Daniel Poneman USA Today Op-Ed September 13, 2011 Deputy Secretary Daniel Poneman USA Today Op-Ed September 13, 2011 PDF icon 091411Poneman USA Today op-ed.pdf...

  15. DOE - Office of Legacy Management -- Quality Hardware and Machine Co - IL

    Office of Legacy Management (LM)

    11 Quality Hardware and Machine Co - IL 11 FUSRAP Considered Sites Site: QUALITY HARDWARE AND MACHINE CO. (IL.11) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Ravenswood Venture Marden Manufacturing Co. IL.11-1 IL.11-2 Location: 5823/5849 North Ravenswood Avenue , Chicago , Illinois IL.11-3 Evaluation Year: 1990 IL.11-4 IL.11-5 Site Operations: From 1944 to 1945, entered into subcontracts with the University of Chicago to furnish personnel,

  16. DOE - Office of Legacy Management -- C-B Tool Products Co - IL 31

    Office of Legacy Management (LM)

    C-B Tool Products Co - IL 31 FUSRAP Considered Sites Site: C-B Tool Products Co. (IL.31 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 956 East 58th Street , Chicago , Illinois IL.31-1 Evaluation Year: 1990 IL.31-2 Site Operations: Provided personnel, facilities, and equipment to produce special machining of parts for special equipment from materials furnished by the University. IL.31-4 Site Disposition: Eliminated - Potential for

  17. DOE - Office of Legacy Management -- Era Tool and Engineering Co - IL 29

    Office of Legacy Management (LM)

    Era Tool and Engineering Co - IL 29 FUSRAP Considered Sites Site: Era Tool and Engineering Co. (IL.29 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Audi-Tex Industries, Incorporated IL.29-1 Location: 4555 West Addison Street , Chicago , Illinois IL.29-2 Evaluation Year: 1989 IL.29-3 Site Operations: From February 1944 through June 1944, provided personnel, facilities, and equipment to produce machined parts for special equipment, tools, jigs,

  18. DOE - Office of Legacy Management -- Max Zuckerman and Sons - IL 30

    Office of Legacy Management (LM)

    - IL 30 FUSRAP Considered Sites Site: MAX ZUCKERMAN & SONS (IL.30 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 1925 N. Kenmore Avenue , Chicago , Illinois IL.30-1 Evaluation Year: 1994 IL.30-2 Site Operations: Sample sized quantities of radioactive materials were shipped through this location; broker arranged purchases of materials for third party buyers. IL.30-2 Site Disposition: Eliminated - Potential for contamination

  19. DOE - Office of Legacy Management -- Museum of Science and Industry - IL 03

    Office of Legacy Management (LM)

    Museum of Science and Industry - IL 03 FUSRAP Considered Sites Site: MUSEUM OF SCIENCE AND INDUSTRY ( IL.03 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 57th Street and Lake Shore Drive , Chicago , Illinois IL.03-1 Evaluation Year: 1985 IL.03-2 IL.03-3 Site Operations: The Metallurgical Laboratory and Argonne National Laboratory occupied space in the Museum of Science and Industry from August 15, 1946 to July 15, 1953. Some handling

  20. Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells

    SciTech Connect (OSTI)

    Kamide, Yosuke; Ishizuka, Tamotsu; Tobo, Masayuki; Tsurumaki, Hiroaki; Aoki, Haruka; Mogi, Chihiro; Nakakura, Takashi; Yatomi, Masakiyo; Ono, Akihiro; Koga, Yasuhiko; Sato, Koichi; Hisada, Takeshi; Dobashi, Kunio; Yamada, Masanobu; Okajima, Fumikazu

    2015-08-28

    Although blood pH is maintained in a narrow range of around pH 7.4 in living organisms, inflammatory loci are characterized by acidic conditions. Mast cells tend to reside close to the surface of the body in areas such as the mucosa and skin where they may be exposed to exogenous acids, and they play an important role in immune responses. However, little is known about the effects of extracellular acidification on the functions of mast cell. Here, we found that extracellular acidification increased the dinitrophenyl-conjugated human serum albumin (DNP-HSA)-induced production of interleukin (IL)-6 and IL-13 in MC/9 cells or bone marrow-derived mouse mast cells sensitized with anti-DNP IgE. Extracellular acidification also inhibited migration of MC/9 cells toward DNP-HSA. In addition, acidic pH stimulated antigen-induced activation of p38 mitogen-activated protein kinase (MAPK) and protein kinase B (Akt). These findings suggest that extracellular acidification augmented antigen/IgE-induced and FcεRI-mediated production of IL-6 and IL-13 in mast cells, and that this was associated with the enhancement of p38 MAPK and Akt activation. - Highlights: • Antigen-induced IL-6 and IL-13 production was augmented by acidic pH in mast cells. • Acidic pH-induced actions were associated with activation of p38 MAPK and Akt. • Inhibition of p38 MAPK and Akt attenuated cytokine responses to acidic pH. • Acidic pH effects are not attributable to actions of known proton-sensing GPCRs.

  1. DuraLamp USA: Proposed Penalty (2010-CE-0912)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that DuraLamp USA, Inc. failed to certify a variety of general service fluorescent lamps as compliant with the applicable energy conservation standards.

  2. Smeg USA: Proposed Penalty (2011-CE-14/1909)

    Office of Energy Efficiency and Renewable Energy (EERE)

    DOE alleged in a Notice of Proposed Civil Penalty that Smeg USA, Inc. failed to certify a variety of dishwashers and refrigerators as compliant with the applicable energy conservation standards.

  3. De'Longhi USA: Order (2010-CE-2114)

    Broader source: Energy.gov [DOE]

    DOE issued an Order after entering into a Compromise Agreement with De'Longhi USA, Inc. to resolve a case involving the failure to certify that a variety of dehumidifiers comply with the applicable energy conservation standards.

  4. De'Longhi USA: Proposed Penalty (2010-CE-2114)

    Broader source: Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that De'Longhi USA, Inc. failed to certify a variety of dehumidifiers as compliant with the applicable energy conservation standards.

  5. Chevron U.S.A. Inc.- 14-119-LNG

    Broader source: Energy.gov [DOE]

    The Office of Fossil Energy gives notice of receipt of an Application filed August 27, 2014 by Chevron U.S.A. Inc. (Chevron), requesting blanket authorization to export liquefied natural gas (LNG)...

  6. TianRun USA Inc | Open Energy Information

    Open Energy Info (EERE)

    Minnesota Sector: Wind energy Product: Minnesota-based investment arm of Goldwind Science & Technology, Beijing Tianrun invested USD 3m to set up the TianRun USA subsidiary in...

  7. DOE - Office of Legacy Management -- Eimco Corp - IL 0-01

    Office of Legacy Management (LM)

    Eimco Corp - IL 0-01 FUSRAP Considered Sites Site: Eimco Corp. (IL.0-01 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Palatine , Illinois IL.0-01-1 Evaluation Year: 1987 IL.0-01-1 Site Operations: Conducted laboratory leaf filtration tests IL.0-01-1 Site Disposition: Eliminated - Potential for contamination considered remote based on the limited scope of activities at the site IL.0-01-1 Radioactive Materials Handled: Yes Primary

  8. DOE - Office of Legacy Management -- Granite City Army Depot - IL 0-02

    Office of Legacy Management (LM)

    Granite City Army Depot - IL 0-02 FUSRAP Considered Sites Site: GRANITE CITY ARMY DEPOT ( IL.0-02 ) Eliminated from consideration under FUSRAP - Referred to DOD Designated Name: Not Designated Alternate Name: None Location: Granite City , Illinois IL.0-02-1 Evaluation Year: 1987 IL.0-02-1 Site Operations: Site was used for storage of GSA thorium residues until circa 1964. IL.0-02-1 Site Disposition: Eliminated - Referred to DOD IL.0-02-1 Radioactive Materials Handled: Yes Primary Radioactive

  9. DOE - Office of Legacy Management -- Midwest Manufacturing Co - IL 0-04

    Office of Legacy Management (LM)

    Midwest Manufacturing Co - IL 0-04 FUSRAP Considered Sites Site: MIDWEST MANUFACTURING CO (IL.0-04 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Evaluation Year: 1987 IL.0-04-3 Site Operations: Research and development on deep drawing of sheet metal in the mid- 1940s. IL.0-04-3 Site Disposition: Site Disposition IL.0-04-1 IL.0-04-3 Radioactive Materials Handled: None Indicated Primary Radioactive Materials Handled: None Indicated

  10. DOE - Office of Legacy Management -- Sciaky Brothers Inc - IL 0-06

    Office of Legacy Management (LM)

    Sciaky Brothers Inc - IL 0-06 FUSRAP Considered Sites Site: SCIAKY BROTHERS, INC (IL.0-06 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 4915 West 67th Street , Chicago , Illinois IL.0-06-1 Evaluation Year: 1987 IL.0-06-2 Site Operations: One time operation involving stitch welding of uranium in 1953. IL.0-06-1 IL.0-06-2 Site Disposition: Eliminated - Potential for contamination considered remote based on limited operations at the site

  11. H2USA Accomplishments Push Hydrogen Infrastructure Forward | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy H2USA Accomplishments Push Hydrogen Infrastructure Forward H2USA Accomplishments Push Hydrogen Infrastructure Forward April 21, 2015 - 4:47pm Addthis A fuel cell electric vehicle (FCEV) at a fueling station in California. A fuel cell electric vehicle (FCEV) at a fueling station in California. Sunita Satyapal Director, Fuel Cell Technologies Office In 2013, auto manufacturers started announcing fuel cell electric vehicle (FCEV) commercialization plans. Since then, Toyota, Hyundai,

  12. Director of Maintenance for USA Jet Airlines, Inc. | National Nuclear

    National Nuclear Security Administration (NNSA)

    Security Administration | (NNSA) Director of Maintenance for USA Jet Airlines, Inc. Rick A. Wilson Rick Wilson July 2009 U.S. General Services Administration (GSA) Aviation Maintenance Professional of the Year Rick A. Wilson has received the U.S. General Services Administration (GSA) Aviation Maintenance Professional of the Year award. Wilson is the director of maintenance for USA Jet Airlines, Inc., in Albuquerque. He manages the maintenance activity of seven different fleet aircraft for

  13. PROJECT PROFILE: Fraunhofer USA, Center for Sustainable Energy Systems CSE

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (SHINES) | Department of Energy Fraunhofer USA, Center for Sustainable Energy Systems CSE (SHINES) PROJECT PROFILE: Fraunhofer USA, Center for Sustainable Energy Systems CSE (SHINES) Title: SunDial - An Integrated SHINES System to Enable High-Penetration Feeder-Level Photovoltaics Fraunhofer logo.png Funding Opportunity: Sustainable and Holistic Integration of Energy Storage and Solar PV SunShot Subprogram: Systems Integration Location: Boston, Massachusetts Partners: National Grid, EnerNOC

  14. DOE - Office of Legacy Management -- Morse Chemical Co - IL 0-05

    Office of Legacy Management (LM)

    Morse Chemical Co - IL 0-05 FUSRAP Considered Sites Site: MORSE CHEMICAL CO. (IL.0-05 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 8 South Michigan Avenue , Chicago , Illinois IL.05-1 Evaluation Year: 1987 IL.05-3 Site Operations: Submitted a bid to AEC for thorium work; proposal was not accepted; no indication work done for a DOE predecessor at this site. IL.05-3 Site Disposition: Eliminated - No Authority - No work for a DOE

  15. #iWNCD W ONTAININO Il@MQWm;

    Office of Legacy Management (LM)

    decontmlmtlon proceam takee longer than originally anticipated 'U&e order .are urgently required to prevent a shutdown. "Z, mo-1 ' 2lda.p - from 4a6-55 to a possible 4-5-55 based on the receipt of vendor's plantby 1-22-55. #iWNCD W ONTAININO Il@MQWm; ;g hours worked; Hours worked will be observed and under the control of . . M%-.'E.Section . (Copy of Vendorts letter of quotation dated l/5/55 is VAWNWWXlINALORDEt :Y $ u(,507.60 upoDRpuiI9APPROPAk &movND* 0 3375.00 (rllaxlmum) Field

  16. FUJIFILM Hunt Chemicals U.S.A. Achieves Compressed Air System...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    FUJIFILM Hunt Chemicals U.S.A. Achieves Compressed Air System Energy-Reduction Goals with a Three-Phased Strategy FUJIFILM Hunt Chemicals U.S.A. Achieves Compressed Air System ...

  17. Solar World USA not SolarWorld AG | Open Energy Information

    Open Energy Info (EERE)

    World USA not SolarWorld AG Jump to: navigation, search Name: Solar World USA (not SolarWorld AG) Place: Colorado Springs, Colorado Zip: 80907 Sector: Solar Product: Solar World...

  18. SEMI-ANNUAL REPORTS FOR GASFIN DEVELOPMENT USA, LLC - FE DKT...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    GASFIN DEVELOPMENT USA, LLC - FE DKT. NO. 13-06-LNG - ORDER 3253 SEMI-ANNUAL REPORTS FOR GASFIN DEVELOPMENT USA, LLC - FE DKT. NO. 13-06-LNG - ORDER 3253 PDF icon April 2013 PDF ...

  19. Eni USA Gas Marketing LLC- FE Dkt. No.- 15-13-LNG

    Broader source: Energy.gov [DOE]

    The Office of Fossil Energy gives notice of receipt of an Application filed January 21, 2015 by Eni USA Gas Marketing LLC (ENI USA Gas Marketing), requesting blanket authorization to export...

  20. SEMI-ANNUAL REPORTS FOR PIERIDAE ENERGY (USA), LTD - DKT. NO...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PIERIDAE ENERGY (USA), LTD - DKT. NO. 14-179-LNG - ORDER 3639 SEMI-ANNUAL REPORTS FOR PIERIDAE ENERGY (USA), LTD - DKT. NO. 14-179-LNG - ORDER 3639 October 2015 (1.1 MB) April 2016 ...

  1. Upcoming H2USA Workshop: Hydrogen Fueling Station Component Listings

    Broader source: Energy.gov [DOE]

    H2USA will host an online workshop about hydrogen fueling station component listings on April 22 from 2 to 3:30 p.m. Eastern Daylight Time. This workshop will focus on the need for components for hydrogen fueling stations to be listed by Nationally Recognized Testing Laboratories (NRTLs).

  2. National Fuel Cell and Hydrogen Energy Overview: Total Energy USA 2012

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation by Sunita Satyapal at the Total Energy USA 2012 meeting in Houston, Texas, on November 27, 2012.

  3. Association study of schizophrenia and IL-2 receptor {beta} chain gene

    SciTech Connect (OSTI)

    Nimgaonkar, V.L.; Yang, Z.W.; Zhang, X.R.; Brar, J.S.

    1995-10-09

    A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2RP chain gene, were examined in both groups. No significant differences in IL-2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2RP gene locus, contrary to the suggestive evidence from linkage analysis in multicase families. 17 refs., 2 tabs.

  4. ENVIRONMENTAL IlONITORING REPORT FOR THE NEVADA TEST SITE AND...

    Office of Legacy Management (LM)

    IlONITORING REPORT FOR THE NEVADA TEST SITE AND OTHER TEST AREAS USED FOR UNDERGROUND NUCLEAR DETONATIONS January through December 1975 Nonitoring Operations Division Environmental ...

  5. 2012 USA Science & Engineering Festival | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    USA Science & Engineering Festival View larger image IMG 0658 View larger image IMG 0659 View larger image IMG 0664 View larger image IMG 0667 View larger image IMG 0682 View larger image IMG 0688 View larger image IMG 0698 View larger image IMG 0701 View larger image IMG 0696 View larger image IMG 0700 View larger image IMG 0712 View larger image IMG 0720 View larger image IMG 0729 View larger image IMG 0738 View larger image IMG 0735

  6. Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction

    SciTech Connect (OSTI)

    Fujii, Hodaka . E-mail: hodaka@med.nyu.edu

    2007-03-16

    Binding of interleukin-2 (IL-2) to its specific receptor induces activation of two members of Jak family protein tyrosine kinases, Jak1 and Jak3. An IL-2 receptor (IL-2R)-reconstituted NIH 3T3 fibroblast cell line proliferates in response to IL-2 only when hematopoietic lineage-specific Jak3 is ectopically expressed. However, the mechanism of Jak3-dependent proliferation in the fibroblast cell line is not known. Here, I showed that Jak3 expression is dispensable for IL-2-induced activation of Jak1 and Stat proteins and expression of nuclear proto-oncogenes in the IL-2R-reconstituted fibroblast cell line. Jak3 expression markedly enhanced these IL-2-induced signaling events. In contrast, Jak3 expression was essential for induction of cyclin genes involved in the G1-S transition. These data suggest a critical role of Jak3 in IL-2 signaling in the fibroblast cell line and may provide further insight into the cell type-specific mechanism of cytokine signaling.

  7. Irreversible inhibition of RANK expression as a possible mechanism for IL-3 inhibition of RANKL-induced osteoclastogenesis

    SciTech Connect (OSTI)

    Khapli, Shruti M.; Tomar, Geetanjali B.; Barhanpurkar, Amruta P.; Gupta, Navita; Yogesha, S.D.; Pote, Satish T.; Wani, Mohan R.

    2010-09-03

    Research highlights: {yields} IL-3 inhibits receptor activator of NF-{kappa}B ligand (RANKL)-induced osteoclastogenesis. {yields} IL-3 inhibits RANKL-induced JNK activation. {yields} IL-3 down-regulates expression of c-Fos and NFATc1 transcription factors. {yields} IL-3 down-regulates RANK expression posttranscriptionally and irreversibly. {yields} IL-3 inhibits in vivo RANK expression. -- Abstract: IL-3, a cytokine secreted by activated T lymphocytes, stimulates the proliferation, differentiation and survival of pluripotent hematopoietic stem cells. In this study, we investigated the mechanism of inhibitory action of IL-3 on osteoclast differentiation. We show here that IL-3 significantly inhibits receptor activator of NF-{kappa}B (RANK) ligand (RANKL)-induced activation of c-Jun N-terminal kinase (JNK). IL-3 down-regulates expression of c-Fos and nuclear factor of activated T cells (NFATc1) transcription factors. In addition, IL-3 down-regulates RANK expression posttranscriptionally in both purified osteoclast precursors and whole bone marrow cells. Furthermore, the inhibitory effect of IL-3 on RANK expression was irreversible. Interestingly, IL-3 inhibits in vivo RANK expression in mice. Thus, we provide the first evidence that IL-3 irreversibly inhibits RANK expression that results in inhibition of important signaling molecules induced by RANKL.

  8. Spin Hall effects in metallic antiferromagnets - perspectives...

    Office of Scientific and Technical Information (OSTI)

    60439, USA, Department of Physics and Astronomy, Northwestern University, Evanston IL ... IL 60616, USA Department of Physics and Astronomy, Northwestern University, Evanston IL ...

  9. EXS-16-0012 - In the Matter of Siemens Medical Solutions USA Inc., Siemens

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Healthcare Diagnostics Inc. | Department of Energy 12 - In the Matter of Siemens Medical Solutions USA Inc., Siemens Healthcare Diagnostics Inc. EXS-16-0012 - In the Matter of Siemens Medical Solutions USA Inc., Siemens Healthcare Diagnostics Inc. On July 5, 2016, OHA granted an Application for Stay filed by Siemens Medical Solutions USA Inc. and Siemens Healthcare Diagnostics Inc. (Siemens) in which the firm requested a stay of enforcement of the applicable provisions of DOE's Energy

  10. MOU signed between CIAE and Jefferson National Lab, USA. (China Nuclear

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Industry News, General News) | Jefferson Lab MOU signed between CIAE and Jefferson National Lab, USA. (China Nuclear Industry News, General News) External Link: https://www.jlab.org/news/articles/mou-signed-between-ciae-and-jefferson-nationa... MOU signed between CIAE and Jefferson National Lab, USA. (News) Recently, the deputy director of Jefferson National Lab, USA visited the China Institute of Atomic Energy (CIAE). An MOU on the collaboration between the two institutions were signed

  11. Join us at the Inaugural USA Science and Engineering Festival! | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy us at the Inaugural USA Science and Engineering Festival! Join us at the Inaugural USA Science and Engineering Festival! October 22, 2010 - 12:00pm Addthis Director Brinkman Director Brinkman Director of the Office of Science What do smart windows and biofuels, climate models and gravity accelerators all have in common? They'll all be part of the Energy Department's exhibits at the inaugural USA Science and Engineering Festival on the National Mall this weekend. The festival

  12. Recent Photovoltaic Performance Data in the USA (Presentation)

    SciTech Connect (OSTI)

    Jordan, D.

    2014-03-01

    This paper presents performance data from nearly 50,000 Photovoltaic systems totaling 1.7 Gigawatts installed capacity in the USA from 2009 to 2012. 90% of the systems performed to within 10% or better of expected performance. Only 2-4% of the data indicate issues significantly affecting the system performance. Special causes of underperformance and their impacts are delineated by reliability category. Delays and interconnections dominate project-related issues particularly in the first year, but total less than 0.5% of all systems. Hardware-related issues are dominated by inverter problems totaling less than 0.4% and underperforming modules to less than 0.1%.

  13. DOW CHEMICAL U.S.A. + WESTERN DIVISION

    Office of Legacy Management (LM)

    DOW CHEMICAL U.S.A. + WESTERN DIVISION 2855 MITCHELL DRIVE WALNUT CREEK. CtyLlFORNlA 94598 October 29,1976 415 944-2300 (., L,'; ! - J. 022 . William J. Thornton Health Protection Branch Safety and Environmental Control Division U.S. Energy Research and Development Administration Oak Ridge Operations P. 0. Box E Oak Ridge, Tennessee 37830 Dear Mr. Thornton: This letter is in response to your request of September 24,1976 for information on records of radiological condition of the laboratories at

  14. OMAE2014 June 8-13, 2014, San Francisco, California, USA OMAE2014-24175

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Proceedings of the ASME 2014 33rd International Conference on Ocean, Offshore and Arctic Engineering OMAE2014 June 8-13, 2014, San Francisco, California, USA OMAE2014-24175 Hydrodynamic Module Coupling in the Offshore Wind Energy Simulation (OWENS) Toolkit Matthew J. Fowler University of Maine Orono, Maine, U.S.A. Andrew J. Goupee University of Maine Orono, Maine, U.S.A. Brian Owens Sandia National Laboratories Albuquerque, New Mexico, U.S.A. John Hurtado Texas A&M University College

  15. Comparison of the ENERGYGAUGE USA and BEopt Building Energy Simulation Programs

    SciTech Connect (OSTI)

    Parker, Danny S.; Cummings, Jamie E.

    2009-08-01

    This report compares two hourly energy simulation softwares, BEopt and Energy Gauge USA, to ensure accuracy and evaluate agreement on the impact of various energy efficiency improvements.

  16. File:USDA-CE-Production-GIFmaps-IL.pdf | Open Energy Information

    Open Energy Info (EERE)

    IL.pdf Jump to: navigation, search File File history File usage Illinois Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  17. DOE - Office of Legacy Management -- Hydroblast Corp - IL 0-03

    Office of Legacy Management (LM)

    FUSRAP Also see Documents Related to HYDROBLAST CORP. IL.0-03-1 - AEC Memorandum; Smith to Malone; Subject: Shipment of Bethlehem Rods, Reference NYC-504; June 22, 1951 ...

  18. IL-33 inhibits RANKL-induced osteoclast formation through the regulation of Blimp-1 and IRF-8 expression

    SciTech Connect (OSTI)

    Kiyomiya, Hiroyasu; Ariyoshi, Wataru; Okinaga, Toshinori; Kaneuji, Takeshi; Mitsugi, Sho; Sakurai, Takuma; Habu, Manabu; Yoshioka, Izumi; Tominaga, Kazuhiro; and others

    2015-05-01

    Interleukin (IL)-33 is a recently discovered proinflammatory cytokine that belongs to the IL-1 family. Several studies have reported that IL-33 inhibits osteoclast differentiation. However, the mechanism of IL-33 regulation of osteoclastogenesis remains unclear. In the present study, we examined the effect of IL-33 on osteoclast formation in vitro. IL-33 suppressed osteoclast formation in both mouse bone marrow cells and monocyte/macrophage cell line RAW264.7 cells induced by receptor activator of NF-κB ligand (RANKL) and/or macrophage stimulating factor (M-CSF). IL-33 also inhibited the expression of RANKL-induced nuclear factor of activated T-cell cytoplasmic 1 (NFATc1), thereby decreasing the expression of osteoclastogenesis-related marker genes, including Cathepsin K, Osteoclast stimulatory transmembrane protein (Oc-stamp) and Tartrate-resistant acid phosphatase (Trap). Blockage of IL-33-ST2 binding suppressed the IL-33-mediated inhibition of NFATc1. RANKL-induced B-lymphocyte-induced maturation protein-1 (Blimp-1) expression was also suppressed by IL-33, which was followed by the stimulation of anti-osteoclastic genes such as interferon regulatory factor-8 (IRF-8). These results suggest that IL-33-ST2 interactions down-regulate both RANKL-induced NFATc1 activation and osteoclast differentiation via the regulation of Blimp-1 and IRF-8 expression. - Highlights: • IL-33 inhibits RANKL-induced osteoclast formation. • IL-33 has inhibitory effect on the RANKL-induced NFATc1 expression. • IL-33-induced NFATc1 suppression depends on the regulation of Blimp-1 and IRF-8.

  19. Webinar: DOE Analysis Related to H2USA | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Analysis Related to H2USA Webinar: DOE Analysis Related to H2USA Below is the text version of the webinar titled "DOE Analysis Related to H2USA," originally presented on July 24, 2013. In addition to this text version of the audio, you can access the presentation slides. Sunita Satyapal: [Audio starts mid-sentence] ...companies typically have internal models that cannot be shared publically while the focus of the DOE model is on transparency and accessibility of the analysis as well as

  20. Secretary Chu Announces Agreement on FutureGen Project in Mattoon, IL |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Agreement on FutureGen Project in Mattoon, IL Secretary Chu Announces Agreement on FutureGen Project in Mattoon, IL June 12, 2009 - 12:00am Addthis Washington, D.C. - U.S. Secretary of Energy Steven Chu today announced an agreement with the FutureGen Alliance that advances the construction of the first commercial scale, fully integrated, carbon capture and sequestration project in the country in Mattoon, Illinois. "This important step forward for FutureGen reflects

  1. NATIONAL GEODATABASE OF TIDAL STREAM POWER RESOURCE IN USA

    SciTech Connect (OSTI)

    Smith, Brennan T; Neary, Vincent S; Stewart, Kevin M

    2012-01-01

    A geodatabase of tidal constituents is developed to present the regional assessment of tidal stream power resource in the USA. Tidal currents are numerically modeled with the Regional Ocean Modeling System (ROMS) and calibrated with the available measurements of tidal current speeds and water level surfaces. The performance of the numerical model in predicting the tidal currents and water levels is assessed by an independent validation. The geodatabase is published on a public domain via a spatial database engine with interactive tools to select, query and download the data. Regions with the maximum average kinetic power density exceeding 500 W/m2 (corresponding to a current speed of ~1 m/s), total surface area larger than 0.5 km2 and depth greater than 5 m are defined as hotspots and documented. The regional assessment indicates that the state of Alaska (AK) has the largest number of locations with considerably high kinetic power density, followed by, Maine (ME), Washington (WA), Oregon (OR), California (CA), New Hampshire (NH), Massachusetts (MA), New York (NY), New Jersey (NJ), North and South Carolina (NC, SC), Georgia (GA), and Florida (FL).

  2. FUJIFILM Hunt Chemicals U.S.A. Achieves Compressed Air System...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    FUJIFILM Hunt Chemicals U.S.A. Achieves Compressed Air System Energy-Reduction Goals with a Three-Phased Strategy In an attempt to eliminate equipment failures and downtime issues ...

  3. Advanced Li-Ion Polymer Battery Cell Manufacturing Plant in USA...

    Broader source: Energy.gov (indexed) [DOE]

    MB) More Documents & Publications Advanced Li-Ion Polymer Battery Cell Manufacturing Plant in USA Li-Ion Battery Cell Manufacturing 2010 DOE, Li-Ion Battery Cell Manufacturing

  4. Energy Efficiency is Beautiful! L'Oréal USA Joins Better Plants...

    Broader source: Energy.gov (indexed) [DOE]

    Johnson280x210.jpg The Department of Energy welcomed L'Oral USA to the Better Buildings, Better Plants Program (Better Plants) and it is a beautiful partnership. As the nation's ...

  5. Global Economic Effects of USA Biofuel Policy and the Potential Contribution from Advanced Biofuels

    SciTech Connect (OSTI)

    Gbadebo Oladosu; Keith Kline; Paul Leiby; Rocio Uria-Martinez; Maggie Davis; Mark Downing; Laurence Eaton

    2012-01-01

    This study evaluates the global economic effects of the USA renewable fuel standards (RFS2), and the potential contribution from advanced biofuels. Our simulation results imply that these mandates lead to an increase of 0.21 percent in the global gross domestic product (GDP) in 2022, including an increase of 0.8 percent in the USA and 0.02 percent in the rest of the world (ROW); relative to our baseline, no-RFS scenario. The incremental contributions to GDP from advanced biofuels in 2022 are estimated at 0.41 percent and 0.04 percent in the USA and ROW, respectively. Although production costs of advanced biofuels are higher than for conventional biofuels in our model, their economic benefits result from reductions in oil use, and their smaller impacts on food markets compared with conventional biofuels. Thus, the USA advanced biofuels targets are expected to have positive economic benefits.

  6. Pieridae Energy (USA) Ltd. FE Dkt. No. 14-179-LNG

    Broader source: Energy.gov [DOE]

    The Office of Fossil Energy gives notice of receipt of an application filed on October 24, 2014, by Pieridae Energy (USA) Ltd (Pieridae) requesting long-term, multi-contract authority as further...

  7. M.; Weaver, J.N.; Wiedemann, H. (Stanford Univ., CA (USA). Stanford

    Office of Scientific and Technical Information (OSTI)

    the 2 MeV microwave gun for the SSRL 150 MeV linac Borland, M.; Weaver, J.N.; Wiedemann, H. (Stanford Univ., CA (USA). Stanford Synchrotron Radiation Lab.); Green, M.C.; Nelson,...

  8. EXS-16-0009- In the Matter of Alcatel-Lucent USA

    Broader source: Energy.gov [DOE]

    On February 23, 2016, OHA granted an Application for Stay filed by Alcatel-Lucent USA (Alcatel).  Alcatel requested a stay of enforcement of DOE's February 2014 Energy Conservation Standards for...

  9. USA Science and Engineering Festival: Inspiring and Educating the Clean Energy Workforce of Tomorrow

    Broader source: Energy.gov [DOE]

    The Energy Department is helping the nation's future STEM workforce (science, technology, engineering, and mathematics) explore energy literacy at the USA Science and Engineering Festival in Washington, D.C. Learn more about the event and how you can participate.

  10. Overview of Station Analysis Tools Developed in Support of H2USA

    Broader source: Energy.gov [DOE]

    Access the recording and download presentation slides from the Fuel Cell Technologies Office webinar "Overview of Station Analysis Tools Developed in Support of H2USA" held on May 12, 2015.

  11. Waste-to-energy: A review of the status and benefits in USA

    SciTech Connect (OSTI)

    Psomopoulos, C.S. Bourka, A.; Themelis, N.J.

    2009-05-15

    The USA has significant experience in the field of municipal solid waste management. The hierarchy of methodologies for dealing with municipal solid wastes consists of recycling and composting, combustion with energy recovery (commonly called waste-to-energy) and landfilling. This paper focuses on waste-to-energy and especially its current status and benefits, with regard to GHG, dioxin and mercury emissions, energy production and land saving, on the basis of experience of operating facilities in USA.

  12. INDUSTRIAL USES OF GEOTHERMAL ENERGY IN THE USA Dr. John W. Lund, PE

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    USES OF GEOTHERMAL ENERGY IN THE USA Dr. John W. Lund, PE Emeritus Director Geo-Heat Center Oregon Institute of Technology Klamath Falls, OR, USA INTRODUCTION  Industrial applications & agricultural drying  Few in number in the U.S.  Large scale operations dominate - Gold ore heap leaching - Onion dehydration  Many small scale operations: - Milk pasteurization, laundry, beer production, alcohol production and mushroom growing. ENERGY USE  Installed capacity = 38 MWt  Annual

  13. Jacob P. Fugal, Scott Spuler Earth Observing Laboratory NCAR, Boulder, CO USA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    airborne digital holographic instrument for measuring the spatial distribution and local size distributions of cloud particles: Holographic Detector for Clouds 2 (HOLODEC 2) Jacob P. Fugal, Scott Spuler Earth Observing Laboratory NCAR, Boulder, CO USA & Raymond A. Shaw Physics Department, michigan Tech Houghton, MI USA C-130 Hercules Q HIAPER Gulfstream GV HOLODEC (Holographic Detector for Clouds) is an airborne instrument that measures the size, shape, and relative 3D position of cloud

  14. Preliminary Analysis of Modules Deployed at PV-USA for 18-24 Years |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Preliminary Analysis of Modules Deployed at PV-USA for 18-24 Years Preliminary Analysis of Modules Deployed at PV-USA for 18-24 Years Presented at the PV Module Reliability Workshop, February 26 - 27 2013, Golden, Colorado pvmrw13_ps1_pvusa_pineda.pdf (417.45 KB) More Documents & Publications Cost of Capital Firearms Qualifications Courses Protective Force Firearms Qualifications Courses, July 2011

  15. 2007-2009 USA Emission Solutions for Heavy-Duty Diesel Engines | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy -2009 USA Emission Solutions for Heavy-Duty Diesel Engines 2007-2009 USA Emission Solutions for Heavy-Duty Diesel Engines 2002 DEER Conference Presentation: Southwest Research Institute 2002_deer_leet.pdf (429.05 KB) More Documents & Publications Low Emisssions Potential of EGR-SCR-DPF and Advanced Fuel Formulations - A Progress Report State-of-the-Art and Emergin Truck Engine Technologies Variable Charge Motion for 2007-2010 Heavy Duty Diesel Engines

  16. Listeriosis Prevention Knowledge Among Pregnant Women in the USA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ogunmodede, Folashade; Jones, Jeffery L.; Scheftel, Joni; Kirkland, Elizabeth; Schulkin, Jay; Lynfield, Ruth

    2005-01-01

    Background: Listeriosis is a food-borne disease often associated with ready-to-eat foods. It usually causes mild febrile gastrointestinal illness in immunocompetent persons. In pregnant women, it may cause more severe infection and often crosses the placenta to infect the fetus, resulting in miscarriage, fetal death or neonatal morbidity. Simple precautions during pregnancy can prevent listeriosis. However, many women are unaware of these precautions and listeriosis education is often omitted from prenatal care. Methods: Volunteer pregnant women were recruited to complete a questionnaire to assess their knowledge of listeriosis and its prevention, in two separate studies. One study was a nationalmore » survey of 403 women from throughout the USA, and the other survey was limited to 286 Minnesota residents. Results: In the multi-state survey, 74 of 403 respondents (18%) had some knowledge of listeriosis, compared with 43 of 286 (15%) respondents to the Minnesota survey. The majority of respondents reported hearing about listeriosis from a medical professional. In the multi-state survey, 33% of respondents knew listeriosis could be prevented by not eating delicatessen meats, compared with 17% in the Minnesota survey ( p = 0.01). Similarly, 31% of respondents to the multi-state survey compared with 19% of Minnesota survey respondents knew listeriosis could be prevented by avoiding unpasteurized dairy products (p = 0.05). As for preventive behaviors, 18% of US and 23% of Minnesota respondents reported avoiding delicatessen meats and ready-to-eat foods during pregnancy, whereas 86% and 88%, respectively, avoided unpasteurized dairy products. Conclusions: Most pregnant women have limited knowledge of listeriosis prevention. Even though most respondents avoided eating unpasteurized dairy products, they were unaware of the risk associated with ready-to-eat foods. Improved education of pregnant women regarding the risk and sources of listeriosis in pregnancy is needed.« less

  17. Crosswell seismic imaging in the Permian Basin, West Texas, USA

    SciTech Connect (OSTI)

    Langan, R.T.; Harris, J.M.; Jensen, T.L.

    1995-12-31

    Crosswell seismic imaging technology has advanced rapidly over the last three years as the processing methods have become more robust, the cost of data acquisition has fallen, and the interwell distances of operation have increased. The Permian Basin of west Texas, USA is proving to be an ideal environment in which to develop this technology because of the relatively low seismic attenuation of the carbonate-dominated lithology, the moderate well spacings in the large number of mature fields, and the unusually high number of reflecting horizons. Current technology permits us to operate in carbonates at well spacings on the order of 2000 ft (650 m) and to image P- and S-wave reflecting horizons on a scale of 8 to 25 ft (2.4 to 7.6 m). Crosswell technology is not limited to carbonates, although the majority of recent applications have been in this environment. We are involved in three separate crosswell experiments in the Permian Basin, each with unique objectives. The first experiment involves a CO{sub 2} pilot project in a Grayburg Formation reservoir on the eastern edge of the Central Basin Platform. Here we are attempting to characterize the reservoir at a scale unobtainable from 3-D surface seismic data and to image CO{sub 2} fronts directly. The second experiment deals with a waterflood in a Middle Clearfork Formation reservoir on the Eastern Shelf, where we are trying to explain the erratic response of adjacent wells to water injection. In the third project we are trying to image the structure and stratigraphy of subtle {open_quotes}anomalies{close_quotes} in 3-D surface seismic images of the Wolfcamp Formation.

  18. IL.26

    Office of Legacy Management (LM)

    ... by the AEC Health and Safety Laboratory; (4) establishment of a program for area clearance after each cycle; (5) supply of the uranium billets allocated for a work cycle ...

  19. DOE Zero Energy Ready Home Case Study: StreetScape Development, LLC, Libertyville, IL, Custom

    Broader source: Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready Home in Libertyville, IL, that scored HERS 45 without PV. This 2,763-square-foot custom home has advanced framed walls with R-20 of open-cell spray foam, R-49 open-cell spray-foam sealed attic, an HRV, and a tankless water heater for hydro coil furnace with high-velocity, small-diameter ducts.

  20. USA RS Basic Contract - Contract No.: DE-RW0000005 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    USA RS Basic Contract - Contract No.: DE-RW0000005 USA RS Basic Contract - Contract No.: DE-RW0000005 This document describes the Statement of Work (SOW) of the Management and Operating Contractor (M&O) Contract for the U.S. Department of Energy (DOE), Office of Civilian Radioactive Waste Management (OCRWM) Program's Yucca Mountain Project (YMP). An M&O contract is defined at Federal Acquisition Regulation (FAR) 17.6 and Department of Energy Acquisition Regulation (DEAR) 970. Inasmuch as

  1. SEMI-ANNUAL REPORTS FOR PIERIDAE ENERGY (USA), LTD - DKT. NO. 14-179-LNG -

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ORDER 3639 | Department of Energy PIERIDAE ENERGY (USA), LTD - DKT. NO. 14-179-LNG - ORDER 3639 SEMI-ANNUAL REPORTS FOR PIERIDAE ENERGY (USA), LTD - DKT. NO. 14-179-LNG - ORDER 3639 October 2015 (1.1 MB) April 2016 (1.05 MB) More Documents & Publications SEMI-ANNUAL REPORTS FOR COMMONWEALTH LNG, LLC (FORMERLY WALLER LNG SERVICES, LLC D/B/A WALLER POINT LNG) - FE DKT. NO. 12-152-LNG - ORDER 3211 SEMI-ANNUAL REPORTS FOR GULF COAST LNG EXPORT, LLC - FE DKT. NO. 12-05-LNG - ORDER 3163

  2. ORDER 3770: BEAR HEAD LNG CORPORATION and BEAR HEAD LNG (USA), LLC |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 3770: BEAR HEAD LNG CORPORATION and BEAR HEAD LNG (USA), LLC ORDER 3770: BEAR HEAD LNG CORPORATION and BEAR HEAD LNG (USA), LLC OPINION AND ORDER GRANTING LONG-TERM, MULTI-CONTRACT AUTHORIZATION TO EXPORT U.S.-SOURCED NATURAL GAS BY PIPELINE TO CANADA FOR LIQUEFACTION AND RE-EXPORT IN THE FORM OF LIQUEFIED NATURAL GAS TO NON-FREE TRADE AGREEMENT COUNTRIES On February 5, 2016, the Energy Department issued an authorization to Bear Head LNG Corporation and Bear Head LNG

  3. Demonstration Assessment of Light-Emitting Diode (LED) Accent Lighting at the Field Museum in Chicago, IL

    SciTech Connect (OSTI)

    Myer, Michael; Kinzey, Bruce R.

    2010-12-10

    This report reviews a demonstration of light-emitting diode (LED) accent lighting compared to halogen (typical) accent lighting in a gallery of the Field Museum in Chicago, IL.

  4. Delivery of human NKG2D-IL-15 fusion gene by chitosan nanoparticles to enhance antitumor immunity

    SciTech Connect (OSTI)

    Yan, Chen; Jie, Leng; Yongqi, Wang; Weiming, Xiao; Juqun, Xi; Yanbing, Ding; Li, Qian; Xingyuan, Pan; Mingchun, Ji; Weijuan, Gong

    2015-07-31

    Nanoparticles are becoming promising carriers for gene delivery because of their high capacity in gene loading and low cell cytotoxicity. In this study, a chitosan-based nanoparticle encapsulated within a recombinant pcDNA3.1-dsNKG2D-IL-15 plasmid was generated. The fused dsNKG2D-IL-15 gene fragment consisted of double extracellular domains of NKG2D with IL-15 gene at downstream. The average diameter of the gene nanoparticles ranged from 200 nm to 400 nm, with mean zeta potential value of 53.8 ± 6.56 mV. The nanoparticles which were loaded with the dsNKG2D-IL-15 gene were uptaken by tumor cells with low cytotoxicity. Tumor cells pre-transfected by gene nanopartilces stimulated NK and T cells in vitro. Intramuscular injection of gene nanoparticles suppressed tumor growth and prolonged survival of tumor-bearing mice through activation of NK and CD8{sup +} T cells. Thus, chitosan-based nanoparticle delivery of dsNKG2D-IL-15 gene vaccine can be potentially used for tumor therapy. - Highlights: • Generation of a nanoparticle for delivery of dsNKG2D-IL-15 gene. • Characterization of the gene nanoparticle. • Antitumor activity mediated by the gene nanoparticle.

  5. U.S. Department of Energy Awards a Contract to USA Repository Services for Management and Operating Contractor Support for the Yucca Mountain Project

    Broader source: Energy.gov [DOE]

    Washington, D.C. -- The U.S. Department of Energy (DOE) today awarded a $2.5 billion management and operating (M&O) contract to USA Repository Services (USA-RS), a wholly-owned subsidiary of...

  6. LG Electronics U.S.A. v. DOE, Stipulation of Voluntary Dismissal

    Broader source: Energy.gov [DOE]

    LG Electronics U.S.A., Inc. v. U.S. Dept. of Energy, Civil Action Number 1:09-cv-02297-JDB - LG voluntarily dismissed its claims against the DOE and agrees to remove the ENERGY STAR labels from various refrigerator-freezers.

  7. DFPARThIl!NT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA DETERlIfiNATION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    s DFPARThIl!NT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA DETERlIfiNATION Page 1 of3 RECIPIENT :State of Hawaii DBEOT STATE : HI PROJECf TITLE: Loan Loss Reserve Funding Opportunity Announc~ment Number DE-FOA-0000052 Procurement Inslrument Number DE-EEOOOO216 NEPA Control Number em Number GF0-0000216-001 GO Based on my review ofthe informalion concerning the proposed aClion, as NEPA Compliance Officer (authorized under DOE Order 451.1A), I have made the following determination: ex, EA, EIS

  8. Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors

    SciTech Connect (OSTI)

    Jin, Sun Hee; Choi, Dalwoong; Chun, Young-Jin; Noh, Minsoo

    2014-10-15

    Keratinocytes are the major cellular components of human epidermis and play a key role in the modulating cutaneous inflammation and toxic responses. In human chronic skin diseases, the common skin inflammatory phenotypes like skin barrier disruption and epidermal hyperplasia are manifested in epidermal keratinocytes by interactions with T helper (Th) cells. To find a common gene expression signature of human keratinocytes in chronic skin diseases, we performed a whole genome microarray analysis on normal human epidermal keratinocytes (NHKs) treated with IFNγ, IL-4, IL-17A or IL-22, major cytokines from Th1, Th2, Th17 or Th22 cells, respectively. The microarray results showed that the four genes, IL-24, PDZK1IP1, H19 and filaggrin, had common expression profiles in NHKs exposed to Th cell cytokines. In addition, the acute phase pro-inflammatory cytokines, IL-1β, IL-6 and TNFα, also change the gene transcriptional profile of IL-24, PDZK1IP1, H19, and filaggrin in NHKs as those of Th cytokines. Therefore, the signature gene set, consisting of IL-24, PDZK1IP1, H19, and filaggrin, provides essential insights for understanding the process of cutaneous inflammation and toxic responses. We demonstrate that environmental toxic stressors, such as chemical irritants and ultraviolet irradiation stimulate the production of IL-24 in NHKs. IL-24 stimulates the JAK1-STAT3 and MAPK pathways in NHKs, and promotes the secretion of pro-inflammatory mediators IL-8, PGE2, and MMP-1. These results suggest that keratinocyte-derived IL-24 participates in the positive feedback regulation of epidermal inflammation in response to both endogenous and environmental toxic stressors. - Highlights: • Cutaneous inflammatory gene signature consists of PDZK1IP1, IL-24, H19 and filaggrin. • Pro-inflammatory cytokines increase IL-24 production in human keratinocytes. • Environmental toxic stressors increase IL-24 production in human keratinocytes. • IL-24 stimulates human keratinocytes to

  9. Google Earth locations of USA and seafloor hydrothermal vents with associated rare earth element data

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Andrew Fowler

    2016-02-10

    Google Earth .kmz files that contain the locations of geothermal wells and thermal springs in the USA, and seafloor hydrothermal vents that have associated rare earth element data. The file does not contain the actual data, the actual data is available through the GDR website in two tier 3 data sets entitled "Compilation of Rare Earth Element Analyses from US Geothermal Fields and Mid Ocean Ridge (MOR) Hydrothermal Vents" and "Rare earth element content of thermal fluids from Surprise Valley, California"

  10. Advanced Li-Ion Polymer Battery Cell Manufacturing Plant in USA |

    Broader source: Energy.gov (indexed) [DOE]

    Department of Energy 2 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting arravt001_es_koo_2012_p.pdf (2.94 MB) More Documents & Publications Advanced Li-Ion Polymer Battery Cell Manufacturing Plant in USA Li-Ion Battery Cell Manufacturing 2010 DOE, Li-Ion Battery Cell Manufacturing

  11. Webinar May 12: Overview of Station Analysis Tools Developed in Support of H2USA

    Broader source: Energy.gov [DOE]

    The Fuel Cell Technologies Office will present a live webinar entitled "Overview of Station Analysis Tools Developed in Support of H2USA" on Tuesday, May 12, from 12 to 1 p.m. Eastern Daylight Time. This webinar will provide a basic introduction to two new models—the Hydrogen Refueling Station Analysis Model (HRSAM) and the Hydrogen Financial Analysis Scenario Tool (H2FAST)—developed by Argonne National Laboratory and the National Renewable Energy Laboratory, respectively.

  12. C. Benedetti BELLA Center, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Efficient modeling of laser-plasma accelerators using the ponderomotive-based code INF&RNO C. Benedetti BELLA Center, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA Laser plasma accelerators (LPAs) can produce accelerating gradients on the order of tens to hundreds of GV/m, making them attractive as compact particle accelerators for radiation production or as drivers for future high-energy colliders. [1, 2] In a laser plasma accelerator, a short and intense laser

  13. Bear Head LNG Corporation and Bear Head LNG (USA), LLC- FE Dkt No. 15-14-NG

    Broader source: Energy.gov [DOE]

    On January 23, 2015, Bear Head LNG Corporation and Bear Head LNG (USA), LLC (together, “Bear Head LNG”), filed an application for long-term, multi-contract authorization to engage in imports from,...

  14. Energy Efficiency is Beautiful! L'Oréal USA Joins Better Plants with Aggressive Energy Efficiency Commitment

    Broader source: Energy.gov [DOE]

    The Department of Energy welcomed L'Oréal USA to the Better Buildings, Better Plants Program (Better Plants) and it is a beautiful partnership. As the nation’s largest cosmetics manufacturer, L...

  15. Estimates of the Global Indirect Energy-Use Emission Impacts of USA Biofuel Policy

    SciTech Connect (OSTI)

    Oladosu, Gbadebo A

    2012-01-01

    This paper evaluates the indirect energy-use emission implications of increases in the use of biofuels in the USA between 2001 and 2010 as mandates within a dynamic global computable general equilibrium model. The study incorporates explicit markets for biofuels, petroleum and other fossil fuels, and accounts for interactions among all sectors of an 18-region global economy. It considers bilateral trade, as well as the dynamics of capital allocation and investment. Simulation results show that the biofuel mandates in the USA generate an overall reduction in global energy use and emissions over the simulation period from 2001 to 2030. Consequently, the indirect energy-use emission change or emission leakage under the mandate is negative. That is, global emission reductions are larger than the direct emission savings from replacing petroleum with biofuels under the USA RFS2 over the last decade. Under our principal scenario this enhanced the direct emission reduction from biofuels by about 66%. The global change in lifecycle energy-use emissions for this scenario was estimated to be about 93 million tons of CO2e in 2010, 45 million tons of CO2e in 2020, and an increase of 5 million tons of CO2e in 2030, relative to the baseline scenario. Sensitivity results of six alternative scenarios provided additional insights into the pattern of the regional and global effects of biofuel mandates on energy-use emissions.

  16. IL1{beta}-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells

    SciTech Connect (OSTI)

    Zhu, Yingting; Tissue Tech Inc, Miami, FL 33173 ; Zhu, Min; Lance, Peter

    2012-11-15

    COX-2 is a major inflammatory mediator implicated in colorectal inflammation and cancer. However, the exact origin and role of COX-2 on colorectal inflammation and carcinogenesis are still not well defined. Recently, we reported that COX-2 and iNOS signalings interact in colonic CCD18Co fibroblasts. In this article, we investigated whether activation of COX-2 signaling by IL1{beta} in primary colonic fibroblasts obtained from normal and cancer patients play a critical role in regulation of proliferation and invasiveness of human colonic epithelial cancer cells. Our results demonstrated that COX-2 level was significantly higher in cancer associated fibroblasts than that in normal fibroblasts with or without stimulation of IL-1{beta}, a powerful stimulator of COX-2. Using in vitro assays for estimating proliferative and invasive potential, we discovered that the proliferation and invasiveness of the epithelial cancer cells were much greater when the cells were co-cultured with cancer associated fibroblasts than with normal fibroblasts, with or without stimulation of IL1{beta}. Further analysis indicated that the major COX-2 product, prostaglandin E{sub 2}, directly enhanced proliferation and invasiveness of the epithelial cancer cells in the absence of fibroblasts. Moreover, a selective COX-2 inhibitor, NS-398, blocked the proliferative and invasive effect of both normal and cancer associate fibroblasts on the epithelial cancer cells, with or without stimulation of IL-1{beta}. Those results indicate that activation of COX-2 signaling in the fibroblasts plays a major role in promoting proliferation and invasiveness of the epithelial cancer cells. In this process, PKC is involved in the activation of COX-2 signaling induced by IL-1{beta} in the fibroblasts.

  17. Expression of low-, intermediate-, and high-affinity IL-2 receptors on B cell lines derived from patients with undifferentiated lymphoma of Burkitt's and non-Burkitt's types

    SciTech Connect (OSTI)

    Benjamin, D.; Rosolen, A.; Wormsley, S.B.; DeBault, L.E.; Colamonici, O.R. )

    1990-08-01

    IL-2 receptors on T cells exist in at least three forms which differ in their ligand-binding affinity. The low-affinity IL-2 receptor (IL-2R) consists of the 55-kDa Tac protein (p55 alpha), the intermediate-affinity site corresponds to the 70-kDa molecule (p70 beta), and the high-affinity IL-2R consists of a noncovalent heterodimeric structure involving both p55 alpha and p70 beta. We studied 24 B cell lines (8 EBV-negative and 16 EBV-positive) for IL-2R expression in the presence or absence of the tumor promoter, teleocidin. 125I-IL-2 radioreceptor binding assays and crosslinking studies demonstrated the sole expression of p55 alpha in EBV-negative cell lines only, whereas p55 alpha present in EBV-positive cell lines was always associated with p70 beta to construct high-affinity IL-2R. p70 beta was not detected in any of the EBV-negative cell lines, but was expressed on most of the EBV-positive cell lines (13 of 16). Our data also indicate that the expression of p55 alpha and p70 beta by radiolabeling correlates with their expression in flow cytometry, and that a large excess of p55 alpha is required to construct high-affinity IL-2R. Coexpression of p55 alpha and p70 beta on human B cells contributed to constructing high-affinity IL-2R hybrid complex as shown by rapid association rate contributed by p55 alpha and slow dissociation rate by p70 beta; teleocidin's ability to induce p55 alpha on cell lines which express p70 beta only, resulting in appearance of high-affinity IL-2R; and blocking p55 alpha by anti-Tac mAb in cell lines which constitutively express high-affinity IL-2R eliminated both high- and low-affinity components. The existence of low, intermediate, and high IL-2R on human B cells bears important future implications for understanding the mechanism of IL-2 signaling and the role of IL-2 in B cell activation, proliferation, and differentiation.

  18. Eu3+ as a dual probe for the determination of IL anion donor power: A combined luminescence spectroscopic and electrochemical approach

    SciTech Connect (OSTI)

    Babai, Arash; Kopiec, Gabriel; Lackmann, Anastasia; Mallick, Bert; Pitula, Slawomir; Tang, Sifu; Mudring, Anja-Verena

    2014-04-01

    This work is aimed at giving proof that Eu(Tf2N)(3) (Tf2N = bis(trifluoromethanesulfonyl)amide) can act as both an optical and electrochemical probe for the determination of the Lewis acidity of an ionic liquid anion. For that reason the luminescence spectra and cyclic voltammograms of dilute solutions of Eu(Tf2N)(3) in various ionic liquids were investigated. The Eu2+/3+ redox potential in the investigated ILs can be related to the Lewis basicity of the IL anion. The IL cation had little influence. The lower the determined halfwave potential, the higher the IL anion basicity. The obtained ranking can be confirmed by luminescence spectroscopy where a bathochromic shift of the D-5(0) -> F-7(4) transition indicates a stronger Lewis basicity of the IL anion. (C) 2014 Published by Elsevier B.V.

  19. WM2015 Conference, March, 15-19, 2015, Phoenix, Arizona, USA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    March, 15-19, 2015, Phoenix, Arizona, USA † Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. This research is funded by WIPP programs administered by the Office of Environmental Management (EM) of the U.S Department of Energy. Impacts of an Additional Exhaust Shaft on WIPP

  20. Overview of Station Analysis Tools Developed in Support of H2USA

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    5/12/2015 U.S. DEPARTMENT OF ENERGY FUEL CELL TECHNOLOGIES OFFICE Overview of Station Analysis Tools Developed in Support of H2USA Presenter(s): Amgad Elgowainy, PhD Marc Melaina, PhD 5/12/2015 Fuel Cell Technologies Office | 2 5/12/2015 Question and Answer * Please type your questions into the question box hydrogenandfuelcells.energy.gov Fuel Cell Technologies Office | 3 5/12/2015 * Welcome and House Keeping - 5 minutes * Hydrogen Refueling Station Analysis Model (HRSAM) - 20 minutes - Amgad

  1. C E N T R A L F IL E S

    Office of Legacy Management (LM)

    ;zJy, y J l . T;? : Tflj~j : - ..- ":'cyi$:T,;L . . :z*:, 0 , _ _ : 7 r;-2 :: '7 .' . A 1 :- :-; '3 s:s:a *;iy,:;.~ ~ r.3 , :,& . fJ . A . -y& ~ :.-, ;,!*3 , J. -. v :+ tn g C E N T R A L F IL E S ~ > m cTpnz '3 F T E iP T h e o b ;ectl'.'e o f th e ? = r i ~ ';lila to d 9 c u s s th e h e a l th a n d s a fe ty a s p e c ts o f a - p r O p O S e d O f? -31'te te s t involving electro n b e a m m e l tin g o f s o l & 2 a m n l u m n e tal a t th e S ta u ffer-Temescal C o m

  2. Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling

    SciTech Connect (OSTI)

    Zhang, Bing; Liu, Caini; Qian, Wen; Han, Yue; Li, Xiaoxia; Deng, Junpeng

    2014-05-01

    Crystal structure of the SEFIR domain from human IL-17 receptor A provides new insights into IL-17 signaling. Interleukin 17 (IL-17) cytokines play a crucial role in mediating inflammatory and autoimmune diseases. A unique intracellular signaling domain termed SEFIR is found within all IL-17 receptors (IL-17Rs) as well as the key adaptor protein Act1. SEFIR-mediated protein–protein interaction is a crucial step in IL-17 cytokine signaling. Here, the 2.3 Å resolution crystal structure of the SEFIR domain of IL-17RA, the most commonly shared receptor for IL-17 cytokine signaling, is reported. The structure includes the complete SEFIR domain and an additional α-helical C-terminal extension, which pack tightly together to form a compact unit. Structural comparison between the SEFIR domains of IL-17RA and IL-17RB reveals substantial differences in protein topology and folding. The uniquely long insertion between strand βC and helix αC in IL-17RA SEFIR is mostly well ordered, displaying a helix (αCC′{sub ins}) and a flexible loop (CC′). The DD′ loop in the IL-17RA SEFIR structure is much shorter; it rotates nearly 90° with respect to the counterpart in the IL-17RB SEFIR structure and shifts about 12 Å to accommodate the αCC′{sub ins} helix without forming any knots. Helix αC was identified as critical for its interaction with Act1 and IL-17-stimulated gene expression. The data suggest that the heterotypic SEFIR–SEFIR association via helix αC is a conserved and signature mechanism specific for IL-17 signaling. The structure also suggests that the downstream motif of IL-17RA SEFIR together with helix αC could provide a composite ligand-binding surface for recruiting Act1 during IL-17 signaling.

  3. Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33 secreted from impaired vessels in the skin compared to fractionated irradiation

    SciTech Connect (OSTI)

    Lee, Eun-Jung; Kim, Jun Won; Yoo, Hyun; Kwak, Woori; Choi, Won Hoon; Cho, Seoae; Choi, Yu Jeong; Lee, Yoon-Jin; Cho, Jaeho

    2015-08-14

    We have revealed in a porcine skin injury model that eosinophil recruitment was dose-dependently enhanced by a single high-dose irradiation. In this study, we investigated the underlying mechanism of eosinophil-associated skin fibrosis and the effect of high-dose-per-fraction radiation. The dorsal skin of a mini-pig was divided into two sections containing 4-cm{sup 2} fields that were irradiated with 30 Gy in a single fraction or 5 fractions and biopsied regularly over 14 weeks. Eosinophil-related Th2 cytokines such as interleukin (IL)-4, IL-5, and C–C motif chemokine-11 (CCL11/eotaxin) were evaluated by quantitative real-time PCR. RNA-sequencing using 30 Gy-irradiated mouse skin and functional assays in a co-culture system of THP-1 and irradiated-human umbilical vein endothelial cells (HUVECs) were performed to investigate the mechanism of eosinophil-mediated radiation fibrosis. Single high-dose-per-fraction irradiation caused pronounced eosinophil accumulation, increased profibrotic factors collagen and transforming growth factor-β, enhanced production of eosinophil-related cytokines including IL-4, IL-5, CCL11, IL-13, and IL-33, and reduced vessels compared with 5-fraction irradiation. IL-33 notably increased in pig and mouse skin vessels after single high-dose irradiation of 30 Gy, as well as in irradiated HUVECs following 12 Gy. Blocking IL-33 suppressed the migration ability of THP-1 cells and cytokine secretion in a co-culture system of THP-1 cells and irradiated HUVECs. Hence, high-dose-per-fraction irradiation appears to enhance eosinophil-mediated fibrotic responses, and IL-33 may be a key molecule operating in eosinophil-mediated fibrosis in high-dose-per fraction irradiated skin. - Highlights: • Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33. • Vascular endothelial cells damaged by high-dose radiation secrete IL-33. • Blocking IL-33 suppressed migration of inflammatory cells and cytokine secretion. • IL

  4. USA National Phenology Network: Plant and Animal Life-Cycle Data Related to Climate Change

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Phenology refers to recurring plant and animal life cycle stages, such as leafing and flowering, maturation of agricultural plants, emergence of insects, and migration of birds. It is also the study of these recurring plant and animal life cycle stages, especially their timing and relationships with weather and climate. Phenology affects nearly all aspects of the environment, including the abundance and diversity of organisms, their interactions with one another, their functions in food webs, and their seasonable behavior, and global-scale cycles of water, carbon, and other chemical elements. Phenology records can help us understand plant and animal responses to climate change; it is a key indicator. The USA-NPN brings together citizen scientists, government agencies, non-profit groups, educators, and students of all ages to monitor the impacts of climate change on plants and animals in the United States. The network harnesses the power of people and the Internet to collect and share information, providing researchers with far more data than they could collect alone.[Extracts copied from the USA-NPN home page and from http://www.usanpn.org/about].

  5. Switchgrass Cultivar/Ecotype Selection and Management for Biofuels in the Upper Southeast USA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lemus, Rocky; Parrish, David J.; Wolf, Dale D.

    2014-01-01

    Switchgrass ( Panicum virgatum L.), a perennial warm-season grass indigenous to the eastern USA, has potential as a biofuels feedstock. The objective of this study was to investigate the performance of upland and lowland switchgrass cultivars under different environments and management treatments. Four cultivars of switchgrass were evaluated from 2000 to 2001 under two management regimes in plots established in 1992 at eight locations in the upper southeastern USA. Two management treatments included 1) a single annual harvest (in late October to early November) and a single application of 50 kg N/ha/yr and 2) two annual harvests (in midsummer andmore » November) and a split application of 100 kg N/ha/yr. Biomass yields averaged 15 Mg/ha/yr and ranged from 10 to 22 Mg/ha/yr across cultivars, managements, locations, and years. There was no yield advantage in taking two harvests of the lowland cultivars (Alamo and Kanlow). When harvested twice, upland cultivars (Cave-in-Rock and Shelter) provided yields equivalent to the lowland ecotypes. Tiller density was 36% lower in stands cutting only once per year, but the stands appeared vigorous after nine years of such management. Lowland cultivars and a one-cutting management (after the tops have senesced) using low rates of applied N (50 kg/ha) are recommended.« less

  6. Comparison of Daytime and Nighttime Populations Adjacent to Interstate Highways in Metropolitan Areas Using LandScan USA

    SciTech Connect (OSTI)

    Johnson, Paul E

    2007-01-01

    An article of similar title was published in the International Journal of Radioactive Materials Transport in 1999. The study concluded that the daytime and nighttime populations are not substantially different for the metropolitan areas examined. This study revisits the issue, but using the LandScan USA high resolution population distribution data, which includes daytime and night-time population. Segments of Interstate highway beltways, along with the direct route through the city, for Atlanta, St. Louis, and Kansas City are examined with an 800m buffer from either side of the highways. The day/night ratio of population is higher using the LandScan USA data. LandScan USA daytime and night-time data will be incorporated into the TRAGIS routing model in future.

  7. HIA 2015 DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Evolutionary Home Builders The Adaptation Home Geneva, IL DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies

  8. DOE Zero Energy Ready Home Case Study 2013: Weiss Building & Development, LLC., Custom Home, Downer Grove, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    LLC Custom Home Downers Grove, IL BUILDING TECHNOLOGIES OFFICE The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR for Homes Version 3 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to give you

  9. DOE Zero Energy Ready Home Case Study: 2013 Weiss Building & Development, LLC., System Home, River Forest, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    LLC System Home River Forest, IL BUILDING TECHNOLOGIES OFFICE The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR for Homes Version 3 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to give you superior

  10. Facile fabrication of rutile monolayer films consisting of well crystalline nanorods by following an IL-assisted hydrothermal route

    SciTech Connect (OSTI)

    Peng Peng; Liu Xiaodi; Sun, Chuansheng; Ma Jianmin; Zheng Wenjun

    2009-05-15

    In this study, rutile films consisting of rectangular nanorods were facilely deposited on glass substrates from strongly acid solution of TiCl{sub 4}. The highly ordered array of nanorods was realized in presence of ionic liquid (IL) of [Bmim]Br by following a hydrothermal process. In this process, Degussa P25 nanoparticles served as seeds that were pre-deposited on the substrates to facilitate the array of rutile nanorods. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Raman spectrum were used to characterize the obtained nanorod films. The measurements showed that the nanorods were rectangular with width of 100-200 nm and length of more than 1 {mu}m, and grew up typically along c-axis to form the arrays against the substrate. The presence of IL was found vital for the formation of rutile nanorods, and the suitable molar ratio of [Bmim]Br to TiCl{sub 4} ranged from 500:1 to 1500:1. The excessive [Bmim]Br may hinder the precipitation of rutile particles. - Graphical abstract: The rutile film consisting of rectangular nanorods is successfully deposited on glass substrate in presence of ionic liquid (IL) of [Bmim]Br. The nanorods were rectangular with width of 100-200 nm and length of more than 1 {mu}m, which grew up typically along c-axis to form the arrays against the substrate.

  11. IL-2R{gamma} gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease

    SciTech Connect (OSTI)

    Henthorn, P.S.; Fimiani, V.M.; Patterson, D.F.

    1994-09-01

    X-linked severe combined immunodeficiency (SCID) is characterized by profound defects in cellular and humoral immunity and, in humans, is associated with mutations in the gene for the {gamma} chain of the IL-2 receptor (IL-2R{gamma}). We have examined this gene in a colony of dogs established from a single X-linked SCID carrier female. Affected dogs have a 4-bp deletion in the first exon of the IL-2R{gamma} gene, which precludes the production of a functional protein, demonstrating that the canine disease is a true homologue of human X-linked SCID. 37 refs., 3 figs.

  12. Intermittent Elevated Radium Concentrations in Coastal Plain Groundwater of South Carolina, U.S.A.

    SciTech Connect (OSTI)

    Denham, Miles; Millings, Margaret; Noonkester, Jay

    2005-09-22

    To learn the cause of intermittent radium concentrations in groundwater of Coastal Plain aquifers, 31 groundwater wells in South Carolina, U.S.A. were sampled for radium and other geochemical parameters. Sediments cored from near the well screens were also sampled to examine any relationship between sediment properties and radium concentration in the groundwater. Elevated radium concentrations only occurred in groundwater with low electrical conductivity and pH values below 6.3. The adsorption edge for radium on hematite--a major surface active mineral in these aquifers--is at a pH value of about 6. Near this value, small changes in pH can result in significant adsorption or desorption of radium. In groundwater with initially low alkalinity, small intermittent decreases in partial pressure of carbon dioxide in groundwater cause decreases in pH and desorption of radium. The result is intermittent elevated radium concentrations.

  13. Risk Assessment of Geologic Formation Sequestration in The Rocky Mountain Region, USA

    SciTech Connect (OSTI)

    Lee, Si-Yong; McPherson, Brian

    2013-08-01

    The purpose of this report is to describe the outcome of a targeted risk assessment of a candidate geologic sequestration site in the Rocky Mountain region of the USA. Specifically, a major goal of the probabilistic risk assessment was to quantify the possible spatiotemporal responses for Area of Review (AoR) and injection-induced pressure buildup associated with carbon dioxide (CO₂) injection into the subsurface. Because of the computational expense of a conventional Monte Carlo approach, especially given the likely uncertainties in model parameters, we applied a response surface method for probabilistic risk assessment of geologic CO₂ storage in the Permo-Penn Weber formation at a potential CCS site in Craig, Colorado. A site-specific aquifer model was built for the numerical simulation based on a regional geologic model.

  14. HIA 2015 DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    BrightLeaf Homes McCormick Avenue Brookfield, IL DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are

  15. Activation of IL-2 receptor {alpha}-chain gene by individual members of the rel oncogene family in association with serum response factor

    SciTech Connect (OSTI)

    Pierce, J.W.; Jamieson, C.A.; Ross, J.L.

    1995-08-15

    Expression of the IL-2R{alpha} gene is regulated by members of the c-Rel/NF-{kappa}B family of transcription factors binding to the {kappa}B site in the promoter. Previous work has not defined the role of individual members of the c-Rel family in the activation of the IL-2R{alpha} gene. Using the COS cell system, we were able to reconstitute the regulation of the IL-2R{alpha} promoter by expressing cloned Rel family members with serum response factor (SRF). We found that c-rel alone activated the IL-2R{alpha} promoter only weakly but worked with the p50 subunit of NF-{kappa}B (NFKB1) to give a higher level of expression. We showed that c-rel heterodimerizes with p50 and the amount of this heterodimer correlated with the level of IL-2R{alpha} gene expression. Our results provide evidence that c-rel/p50 heterodimers activate gene expression in the context of a cellular promoter. We show that c-rel or p65 can cooperate with SRF in the activation of this promoter and the transactivation by c-rel with SRF was enhanced by p50. Synergistic activation required both {kappa}B an CArG sites, and binding studies show that these that these adjacent sites can be occupied simultaneously. The transactivation observed with cloned transcription factors mimics the physiologic induction of the IL-2R{alpha} gene since multiple sequence elements cooperate to give gene activation. The data support the model that c-rel/p50 or p65 can cooperate with SRF to specifically target the expression of the IL-2R{alpha} gene in activated T cells.

  16. Enhancing Disaster Management: Development of a Spatial Database of Day Care Centers in the USA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Singh, Nagendra; Tuttle, Mark A.; Bhaduri, Budhendra L.

    2015-07-30

    Children under the age of five constitute around 7% of the total U.S. population and represent a segment of the population, which is totally dependent on others for day-to-day activities. A significant proportion of this population spends time in some form of day care arrangement while their parents are away from home. Accounting for those children during emergencies is of high priority, which requires a broad understanding of the locations of such day care centers. As concentrations of at risk population, the spatial location of day care centers is critical for any type of emergency preparedness and response (EPR). However,more » until recently, the U.S. emergency preparedness and response community did not have access to a comprehensive spatial database of day care centers at the national scale. This paper describes an approach for the development of the first comprehensive spatial database of day care center locations throughout the USA utilizing a variety of data harvesting techniques to integrate information from widely disparate data sources followed by geolocating for spatial precision. In the context of disaster management, such spatially refined demographic databases hold tremendous potential for improving high resolution population distribution and dynamics models and databases.« less

  17. Life history and demography of the common mud turtle Kinosternon subrubrum in South Carolina, USA

    SciTech Connect (OSTI)

    Frazier, N.B. ); Gibbons, J.W.; Greene, J.L. )

    1992-01-01

    This paper presents a life table for the common mud turtle, Kinosternon subrubrum, in a fluctuating aquatic habitat on the Upper Coastal Plain of South Carolina, USA, using data gathered in a 20-yr mark-recapture study. Data on survivorship and fecundity were assessed and compared to previously published life table statistics for the slider turtle, Trachemys scripta, in the same body of water and for the yellow mud turtle, K. flavscens, in Nebraska. The annual survival rate for adult female Kinosternon is significantly higher than that of adult female Trachemys. Similarly, male Kinosternon exhibit an annual survival rate significantly higher than that of male Trachemys. The mean annual proportion of female Kinosternon that are reproductively active also is significantly higher than that of Trachemys. In addition, survival rate from the time eggs are laid by Kinosternon until the hatchlings enter the aquatic environment is significantly higher than that for Trachemys. Comparisons of findings with those for K. flavesens indicate that these geographically separate populations of congeneric species also differ substantially in age at maturity, mean generation time, and the mean proportion of females that are reproductively active in any given year. Differences were also apparent in mean clutch frequencies and adult survival rates.

  18. Three-Dimensional Geologic Characterization of Geothermal Systems: Astor Pass, Nevada, USA

    SciTech Connect (OSTI)

    Siler, Drew L; Mayhew, Brett; Faulds, James E

    2012-09-30

    Geothermal systems in the Great Basin, USA, are controlled by a variety of fault intersection and fault interaction areas. Understanding the specific geometry of the structures most conducive to geothermal circulation is crucial in order to both mitigate the costs of geothermal exploration (especially drilling) and to identify blind geothermal systems (no surface expression). Astor Pass, Nevada, one such blind geothermal system, lies near the boundary between two distinct structural domains, the Walker Lane and the Basin and Range, and exhibits characteristics of each setting. Both northwest-striking, left-stepping dextral faults of the Walker Lane and kinematically linked northerly striking normal faults associated with the Basin and Range are present at Astor Pass. Previous studies identified a blind geothermal system controlled by the intersection of northwest-striking dextral and north-northwest-striking normal faults. Wells drilled into the southwestern quadrant of the fault intersection yielded 94˚C fluids, with geothermometers suggesting significantly higher maximum temperatures. Additional data, including reprocessed 2D seismic data and petrologic analysis of well cuttings, were integrated with existing and reinterpreted geologic maps and cross-sections to aid construction of a 3D geologic model. This comprehensive 3D integration of multiple data sets allows characterization of the structural setting of the Astor Pass blind geothermal system at a level of detail beyond what independent data interpretation can provide. Our analysis indicates that the blind geothermal system is controlled by two north- to northwest-plunging fault intersections.

  19. Sluiceway Operations for Adult Steelhead Downstream Passage at The Dalles Dam, Columbia River, USA

    SciTech Connect (OSTI)

    Khan, Fenton; Royer, Ida M.; Johnson, Gary E.; Tackley, Sean C.

    2013-10-01

    This study evaluated adult steelhead (Oncorhynchus mykiss; fallbacks and kelts) downstream passage at The Dalles Dam in the Columbia River, USA, during the late fall, winter, and early spring months between 2008 and 2011. The purpose of the study was to determine the efficacy of operating the dam’s ice-and-trash sluiceway during non-spill months to provide a relatively safe, non-turbine, surface outlet for overwintering steelhead fallbacks and downstream migrating steelhead kelts. We applied the fixed-location hydroacoustic technique to estimate fish passage rates at the sluiceway and turbines of the dam. The spillway was closed during our sampling periods, which generally occurred in late fall, winter, and early spring. The sluiceway was highly used by adult steelhead (91–99% of total fish sampled passing the dam) during all sampling periods. Turbine passage was low when the sluiceway was not operated. This implies that lack of a sluiceway route did not result in increased turbine passage. However, when the sluiceway was open, adult steelhead used it to pass through the dam. The sluiceway may be operated during late fall, winter, and early spring to provide an optimal, non-turbine route for adult steelhead (fallbacks and kelts) downstream passage at The Dalles Dam.

  20. Enhancing Disaster Management: Development of a Spatial Database of Day Care Centers in the USA

    SciTech Connect (OSTI)

    Singh, Nagendra; Tuttle, Mark A.; Bhaduri, Budhendra L.

    2015-07-30

    Children under the age of five constitute around 7% of the total U.S. population and represent a segment of the population, which is totally dependent on others for day-to-day activities. A significant proportion of this population spends time in some form of day care arrangement while their parents are away from home. Accounting for those children during emergencies is of high priority, which requires a broad understanding of the locations of such day care centers. As concentrations of at risk population, the spatial location of day care centers is critical for any type of emergency preparedness and response (EPR). However, until recently, the U.S. emergency preparedness and response community did not have access to a comprehensive spatial database of day care centers at the national scale. This paper describes an approach for the development of the first comprehensive spatial database of day care center locations throughout the USA utilizing a variety of data harvesting techniques to integrate information from widely disparate data sources followed by geolocating for spatial precision. In the context of disaster management, such spatially refined demographic databases hold tremendous potential for improving high resolution population distribution and dynamics models and databases.

  1. Reliability and Geographic Trends of 50,000 Photovoltaic Systems in the USA: Preprint

    SciTech Connect (OSTI)

    Jordan, D. C.; Kurtz, S. R.

    2014-09-01

    This paper presents performance and reliability data from nearly 50,000 photovoltaic (PV) systems totaling 1.7 gigawatts installed capacity in the USA from 2009 to 2012 and their geographic trends. About 90% of the normal systems and about 85% of all systems, including systems with known issues, performed to within 10% or better of expected performance. Although considerable uncertainty may exist due to the nature of the data, hotter climates appear to exhibit some degradation not seen in the more moderate climates. Special causes of underperformance and their impacts are delineated by reliability category. Hardware-related issues are dominated by inverter problems (totaling less than 0.5%) and underperforming modules (totaling less than 0.1%). Furthermore, many reliability categories show a significant decrease in occurrence from year 1 to subsequent years, emphasizing the need for higher-quality installations but also the need for improved standards development. The probability of PV system damage because of hail is below 0.05%. Singular weather events can have a significant impact such as a single lightning strike to a transformer or the impact of a hurricane. However, grid outages are more likely to have a significant impact than PV system damage when extreme weather events occur.

  2. Enhancing Disaster Management: Development of a Spatial Database of Day Care Centers in the USA

    SciTech Connect (OSTI)

    Singh, Nagendra; Tuttle, Mark A; Bhaduri, Budhendra L

    2015-01-01

    Children under the age of five constitute around 7% of the total U.S. population and represent a segment of the population, which is totally dependent on others for day-to-day activities. A significant proportion of this population spends time in some form of day care arrangement while their parents are away from home. Accounting for those children during emergencies is of high priority, which requires a broad understanding of the locations of such day care centers. As concentrations of at risk population, the spatial location of day care centers is critical for any type of emergency preparedness and response (EPR). However, until recently, the U.S. emergency preparedness and response community did not have access to a comprehensive spatial database of day care centers at the national scale. This paper describes an approach for the development of the first comprehensive spatial database of day care center locations throughout the USA utilizing a variety of data harvesting techniques to integrate information from widely disparate data sources followed by geolocating for spatial precision. In the context of disaster management, such spatially refined demographic databases hold tremendous potential for improving high resolution population distribution and dynamics models and databases.

  3. Recovery Act: ArcelorMittal USA Blast Furnace Gas Flare Capture

    SciTech Connect (OSTI)

    Seaman, John

    2013-01-14

    The U.S. Department of Energy (DOE) awarded a financial assistance grant under the American Recovery and Reinvestment Act of 2009 (Recovery Act) to ArcelorMittal USA, Inc. (ArcelorMittal) for a project to construct and operate a blast furnace gas recovery boiler and supporting infrastructure at ArcelorMittal’s Indiana Harbor Steel Mill in East Chicago, Indiana. Blast furnace gas (BFG) is a by-product of blast furnaces that is generated when iron ore is reduced with coke to create metallic iron. BFG has a very low heating value, about 1/10th the heating value of natural gas. BFG is commonly used as a boiler fuel; however, before installation of the gas recovery boiler, ArcelorMittal flared 22 percent of the blast furnace gas produced at the No. 7 Blast Furnace at Indiana Harbor. The project uses the previously flared BFG to power a new high efficiency boiler which produces 350,000 pounds of steam per hour. The steam produced is used to drive existing turbines to generate electricity and for other requirements at the facility. The goals of the project included job creation and preservation, reduced energy consumption, reduced energy costs, environmental improvement, and sustainability.

  4. Rare earth elements in chloride-rich groundwater, Palo Duro Basin, Texas, USA

    SciTech Connect (OSTI)

    Gosselin, D.C. ); Smith, M.R.; Lepel, E.A. ); Laul, J.C. )

    1992-04-01

    Rare earth element (REE) data for groundwater samples from the Deep-Basin Brine aquifer of the Palo Duro Basin, Texas, USA, illustrates the potential use of REE for inferring groundwater flow paths through different geologic materials. The REE content of the groundwaters range over 2.5 orders of magnitude and are depleted by 10{sup 2} to 10{sup 5} relative to aquifer materials. The shale-normalized REE patterns for groundwater that have primarily interacted with arkosic sandstones (granite wash) are flat with similar heavy REE (HREE) enrichments ((Lu/La){sub n} = 0.60 to 0.80). The samples with highest REE contents and REE patterns, which are enriched in the intermediate REEs (IREEs; Sm-Tb) reflect variable degrees of interaction with carbonate rocks. The IREE enrichment is the result of fluid interaction with Fe-Mn coatings on carbonate minerals and/or secondary minerals in fractures and vugs. The chloride complex. (LnCl{sup 2+}), and free-ions are the predominant REE species, accounting for over 95% of the REEs. Carbonate and sulfate species account for the other 5% and have very little influence on the behavior of the REEs. Although this study indicates a potentially important role for the REEs in understanding geochemical transport and groundwater movement, it also indicates the necessity for developing a better understanding of REE speciation in high ionic strength solutions.

  5. Spin valve with non-collinear magnetization configuration imprinted...

    Office of Scientific and Technical Information (OSTI)

    Material Science Division, Argonne National Laboratory, Argonne, IL 60439, USA, Department of Physics and Astronomy, Texas A&M University, College Station, TX 77843-4242, USA ...

  6. EA-1188: Chevron U.S.A., Inc. and Santa Fe Energy Resources, Inc. Midway Valley 3D Seismic Project, Kern County, California

    Broader source: Energy.gov [DOE]

    This EA evaluates the environmental impacts for the proposed Midway Valley 3D Geophysical Exploration Project. Chevron U.S.A., Inc. and Santa Fe Energy Resources are proposing to conduct seismic...

  7. Immunosuppressive effect of the anti-IL-2-receptor monoclonal antibody, AMT-13, on organ-cultured fetal pancreas allograft survival

    SciTech Connect (OSTI)

    Burkhardt, K.; Loughnan, M.S.; Diamantstein, T.; Mandel, T.E.

    1988-11-01

    Recently, prolongation of cardiac allograft survival in mice was reported using a rat anti-IL-2R mAb (AMT-13). However, its immunosuppressive action in vivo, alone and in combination with other immunosuppressants, and its effect on other organ transplants has not been extensively studied. We grafted cultured fetal pancreas from CBA (H-2k) donors to Balb/c (H-2d) mice. Recipients were treated with 10 consecutive daily injections each of 20 micrograms AMT-13 only, or with an additional mild immunosuppression of 350 rads irradiation. Control groups received rat immunoglobulin or 350 rads irradiation. Graft survival and the phenotype of infiltrating cells were assessed histologically and immunocytochemically on days 12, 17, and 21, and soluble IL-2R levels were measured in the serum with a quantitative ELISA in all recipients. Two of five grafts in the AMT-13-treated group had islets on day 12 posttransplantation despite lymphocytic infiltration in all grafts, while at this time all grafts of rat Ig treated control mice were completely rejected with only scar tissue and a few lymphocytes remaining. Additional immunosuppression with 350 rads irradiation had a marked additive effect with AMT-13. Soluble IL-2R levels in the serum of untreated recipients were not elevated compared with normal serum levels, but recipients injected with AMT-13 had multifold increased soluble IL-2R levels. The percentage of IL-2R+ cells in the grafts of AMT-13-treated animals was either normal (less than 5%) or increased (20%) in the additionally irradiated mice, providing strong evidence that the immunosuppressive effect of AMT-13 is not due to a depletion of activated IL-2R+ lymphocytes.

  8. Thermal spray removal of lead-based paint from the viaduct bridge at Rock Island Arsenal, IL. Final report

    SciTech Connect (OSTI)

    Boy, J.H.; Weber, R.A.; Kumar, A.

    1998-06-01

    This report documents a field demonstration at the Rock Island Arsenal, IL, that validated the thermal spray vitrification (TSV) process as a safe and effective technique for removing lead-based paint from a steel bridge. Specially formulated glass was applied in a molten state to painted steel using a conventional thermal spray application system. The molten glass reacts with the paint, and encapsulates the lead. The cooled glass readily cracks and falls off, removing the paint. After onsite remelting of the glass waste to complete the encapsulation process, the final waste product is chemically inert and may be disposed of in a regular landfill. The Illinois Environmental Protection Agency, Division of Air Pollution Control determined that the glass remelt process could be considered a paint-removal operation for which no air quality permit was required.

  9. Identification of multiple mercury sources to stream sediments near Oak Ridge, TN, USA

    SciTech Connect (OSTI)

    Donovan, Patrick M.; Blum, Joel D.; Demers, Jason D.; Gu, Baohua; Brooks, Scott C.; Peryam, John

    2014-03-03

    In this paper, sediments were analyzed for total Hg concentration (THg) and isotopic composition from streams and rivers in the vicinity of the Y-12 National Security Complex (Y12) in Oak Ridge, TN (USA). In the stream directly draining Y12, where industrial releases of mercury (Hg) have been documented, high THg (3.26 to 60.1 μg/g) sediments had a distinct Hg isotopic composition (δ202Hg of 0.02 ± 0.15‰ and Δ199Hg of -0.07 ± 0.03‰; mean ± 1SD, n=12) compared to sediments from relatively uncontaminated streams in the region (δ202Hg = -1.40 ± 0.06‰ and Δ199Hg of –0.26 ± 0.03‰; mean ± 1SD, n=6). Additionally, several streams that are nearby but do not drain Y12 had sediments with intermediate THg (0.06 to 0.21 μg/g) and anomalous δ202Hg (as low as -5.07‰). We suggest that the low δ202Hg values in these sediments provide evidence for the contribution of an additional Hg source to sediments, possibly derived from atmospheric deposition. In sediments directly downstream of Y12 this third Hg source is not discernible and the Hg isotopic composition can be largely explained by the mixing of low THg sediments with high THg sediments contaminated by Y12 discharges.

  10. Mineralogic Investigation into Occurrence of High Uranium Well Waters in Upstate South Carolina USA

    SciTech Connect (OSTI)

    R Warner; J Meadows; S Sojda; V Price; T Temples; Y Arai; C Fleisher; B Crawford; P Stone

    2011-12-31

    High levels of U (up to 5570 {micro}g/L) have been discovered in well waters near Simpsonville, South Carolina, USA. In order to characterize the mineralogical source of the U and possible structural controls on its presence, a deep (214 m) well was cored adjacent to one of the enriched wells. The highest gamma-ray emissions in the recovered core occur in coarse biotite granite at a depth just below 52 m. A slickenlined fault plane at 48.6 m and narrow pegmatite layers at depths of 113, 203 and 207 m also yield high gamma-ray counts. Thin sections were made from the above materials and along several subvertical healed fractures. Uraninite and coffinite are the principal U-rich minerals in the core. Other U-bearing minerals include thorite and thorogummite, monazite, zircon and allanite. Primary uraninite occurs in the biotite granite and in pegmatite layers. Secondary coffinite is present as tiny (<5 {micro}m) crystals dispersed along fractures in the granite and pegmatites. Coffinite also occurs along the slickenlined fault plane, where it is associated with calcite and calcic zeolite and also replaces allanite. Coffinite lacks radiogenic Pb, hence is considerably younger than the uraninite. Dissolution of partially oxidized Ca-rich uraninite occurring in the surficial biotite granite (or secondary coffinite in fracture zones) is likely the main source for the current high levels of U in nearby area wells. The high-U well waters have a carbonate signature, consistent with pervasive calcite vein mineralization in the core. Aqueous speciation calculations suggest U transport as an uranyl (U{sup 6+}) hydroxyl-carbonate complex. Later reduction resulted in secondary precipitation along fractures as a U{sup 4+} mineral (i.e., coffinite).

  11. Refining the site conceptual model at a former uranium mill site in Riverton, Wyoming, USA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dam, William; Campbell, Sam; Johnson, Ray; Looney, Brian; Denham, Miles E.; Eddy-Dilek, Carol A.; Babits, Steven J.

    2015-07-07

    Milling activities at a former uranium mill site near Riverton, Wyoming, USA, contaminated the shallow groundwater beneath and downgradient of the site. Although the mill operated for <6 years (1958-1963), its impact remains an environmental liability. Groundwater modeling predicted that contaminant concentrations were declining steadily, which confirmed the conceptual site model (CSM). However, local flooding in 2010 mobilized contaminants that migrated downgradient from the Riverton site and resulted in a dramatic increase in groundwater contaminant concentrations. This observation indicated that the original CSM was inadequate to explain site conditions and needed to be refined. In response to the new observationsmore » after the flood, a collaborative investigation to better understand site conditions and processes commenced. This investigation included installing 103 boreholes to collect soil and groundwater samples, sampling and analysis of evaporite minerals along the bank of the Little Wind River, an analysis of evaportranspiration in the shallow aquifer, and sampling naturally organic-rich sediments near groundwater discharge areas. The enhanced characterization revealed that the existing CSM did not account for high uranium concentrations in groundwater remaining on the former mill site and groundwater plume stagnation near the Little Wind River. Observations from the flood and subsequent investigations indicate that additional characterization is still needed to continue refining the CSM and determine the viability of the natural flushing compliance strategy. Additional sampling, analysis, and testing of soil and groundwater are necessary to investigate secondary contaminant sources, mobilization of contaminants during floods, geochemical processes, contaminant plume stagnation, distribution of evaporite minerals and organic-rich sediments, and mechanisms and rates of contaminant transfer from soil to groundwater. Future data collection will be used to

  12. A retrospective tiered environmental assessment of the Mount Storm Wind Energy Facility, West Virginia,USA

    SciTech Connect (OSTI)

    Efroymson, Rebecca Ann; Day, Robin; Strickland, M. Dale

    2012-11-01

    Bird and bat fatalities from wind energy projects are an environmental and public concern, with post-construction fatalities sometimes differing from predictions. Siting facilities in this context can be a challenge. In March 2012 the U.S. Fish and Wildlife Service (USFWS) released Land-based Wind Energy Guidelines to assess collision fatalities and other potential impacts to species of concern and their habitats to aid in siting and management. The Guidelines recommend a tiered approach for assessing risk to wildlife, including a preliminary site evaluation that may evaluate alternative sites, a site characterization, field studies to document wildlife and habitat and to predict project impacts, post construction studies to estimate impacts, and other post construction studies. We applied the tiered assessment framework to a case study site, the Mount Storm Wind Energy Facility in Grant County, West Virginia, USA, to demonstrate the use of the USFWS assessment approach, to indicate how the use of a tiered assessment framework might have altered outputs of wildlife assessments previously undertaken for the case study site, and to assess benefits of a tiered ecological assessment framework for siting wind energy facilities. The conclusions of this tiered assessment for birds are similar to those of previous environmental assessments for Mount Storm. This assessment found risk to individual migratory tree-roosting bats that was not emphasized in previous preconstruction assessments. Differences compared to previous environmental assessments are more related to knowledge accrued in the past 10 years rather than to the tiered structure of the Guidelines. Benefits of the tiered assessment framework include good communication among stakeholders, clear decision points, a standard assessment trajectory, narrowing the list of species of concern, improving study protocols, promoting consideration of population-level effects, promoting adaptive management through post

  13. Refining the site conceptual model at a former uranium mill site in Riverton, Wyoming, USA

    SciTech Connect (OSTI)

    Dam, William; Campbell, Sam; Johnson, Ray; Looney, Brian; Denham, Miles E.; Eddy-Dilek, Carol A.; Babits, Steven J.

    2015-07-07

    Milling activities at a former uranium mill site near Riverton, Wyoming, USA, contaminated the shallow groundwater beneath and downgradient of the site. Although the mill operated for <6 years (1958-1963), its impact remains an environmental liability. Groundwater modeling predicted that contaminant concentrations were declining steadily, which confirmed the conceptual site model (CSM). However, local flooding in 2010 mobilized contaminants that migrated downgradient from the Riverton site and resulted in a dramatic increase in groundwater contaminant concentrations. This observation indicated that the original CSM was inadequate to explain site conditions and needed to be refined. In response to the new observations after the flood, a collaborative investigation to better understand site conditions and processes commenced. This investigation included installing 103 boreholes to collect soil and groundwater samples, sampling and analysis of evaporite minerals along the bank of the Little Wind River, an analysis of evaportranspiration in the shallow aquifer, and sampling naturally organic-rich sediments near groundwater discharge areas. The enhanced characterization revealed that the existing CSM did not account for high uranium concentrations in groundwater remaining on the former mill site and groundwater plume stagnation near the Little Wind River. Observations from the flood and subsequent investigations indicate that additional characterization is still needed to continue refining the CSM and determine the viability of the natural flushing compliance strategy. Additional sampling, analysis, and testing of soil and groundwater are necessary to investigate secondary contaminant sources, mobilization of contaminants during floods, geochemical processes, contaminant plume stagnation, distribution of evaporite minerals and organic-rich sediments, and mechanisms and rates of contaminant transfer from soil to groundwater. Future data collection will be used to

  14. Identification of multiple mercury sources to stream sediments near Oak Ridge, TN, USA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Donovan, Patrick M.; Blum, Joel D.; Demers, Jason D.; Gu, Baohua; Brooks, Scott C.; Peryam, John

    2014-03-03

    In this paper, sediments were analyzed for total Hg concentration (THg) and isotopic composition from streams and rivers in the vicinity of the Y-12 National Security Complex (Y12) in Oak Ridge, TN (USA). In the stream directly draining Y12, where industrial releases of mercury (Hg) have been documented, high THg (3.26 to 60.1 μg/g) sediments had a distinct Hg isotopic composition (δ202Hg of 0.02 ± 0.15‰ and Δ199Hg of -0.07 ± 0.03‰; mean ± 1SD, n=12) compared to sediments from relatively uncontaminated streams in the region (δ202Hg = -1.40 ± 0.06‰ and Δ199Hg of –0.26 ± 0.03‰; mean ± 1SD,more » n=6). Additionally, several streams that are nearby but do not drain Y12 had sediments with intermediate THg (0.06 to 0.21 μg/g) and anomalous δ202Hg (as low as -5.07‰). We suggest that the low δ202Hg values in these sediments provide evidence for the contribution of an additional Hg source to sediments, possibly derived from atmospheric deposition. In sediments directly downstream of Y12 this third Hg source is not discernible and the Hg isotopic composition can be largely explained by the mixing of low THg sediments with high THg sediments contaminated by Y12 discharges.« less

  15. Solute concentrations influence microbial methanogenesis in coal-bearing strata of the Cherokee basin, USA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kirk, Matthew F.; Wilson, Brien H.; Marquart, Kyle A.; Zeglin, Lydia H.; Vinson, David S.; Flynn, Theodore M.

    2015-11-18

    In this study, microorganisms have contributed significantly to subsurface energy resources by converting organic matter in hydrocarbon reservoirs into methane, the main component of natural gas. In this study, we consider environmental controls on microbial populations in coal-bearing strata of the Cherokee basin, an unconventional natural gas resource in southeast Kansas, USA. Pennsylvanian-age strata in the basin contain numerous thin (0.4–1.1 m) coalbeds with marginal thermal maturities (0.5–0.7% Ro) that are interbedded with shale and sandstone. We collected gas, water, and microbe samples from 16 commercial coalbed methane wells for geochemical and microbiological analysis. The water samples were Na–Cl typemore » with total dissolved solids (TDS) content ranging from 34.9 to 91.3 g L–1. Gas dryness values [C1/(C2 + C3)] averaged 2640 and carbon and hydrogen isotope ratios of methane differed from those of carbon dioxide and water, respectively, by an average of 65 and 183‰. These values are thought to be consistent with gas that formed primarily by hydrogenotrophic methanogenesis. Results from cultivation assays and taxonomic analysis of 16S rRNA genes agree with the geochemical results. Cultivable methanogens were present in every sample tested, methanogen sequences dominate the archaeal community in each sample (avg 91%), and few archaeal sequences (avg 4.2%) were classified within Methanosarcinales, an order of methanogens known to contain methylotrophic methanogens. Although hydrogenotrophs appear dominant, geochemical and microbial analyses both indicate that the proportion of methane generated by acetoclastic methanogens increases with the solute content of formation water, a trend that is contrary to existing conceptual models. Consistent with this trend, beta diversity analyses show that archaeal diversity significantly correlates with formation water solute content. In contrast, bacterial diversity more strongly correlates with location

  16. ROS and NF-{kappa}B are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes

    SciTech Connect (OSTI)

    Ye Shefang Wu Yihui; Hou Zhenqing; Zhang Qiqing

    2009-02-06

    Carbon nanotubes (CNTs) have potential applications in biosensors, tissue engineering, and biomedical devices because of their unique physico-chemical, electronic and mechanical properties. However, there is limited literature data available concerning the biological properties and toxicity of CNTs. This study aimed to assess the toxicity exhibited by multi-walled CNTs (MWCNTs) and to elucidate possible molecular mechanisms underlying the biological effects of MWCNTs in A549 cells. Exposing A549 cells to MWCNTs led to cell death, changes in cell size and complexity, reactive oxygen species (ROS) production, interleukin-8 (IL-8) gene expression and nuclear factor (NF)-{kappa}B activation. Treatment of A549 cells with antioxidants prior to adding MWCNTs decreased ROS production and abrogated expression of IL-8 mRNA. Pretreatment of A549 cells with NF-{kappa}B inhibitors suppressed MWCNTs-induced IL-8 mRNA expression. These results indicate that MWCNTs are able to induce expression of IL-8 in A549 cells, at least in part, mediated by oxidative stress and NF-{kappa}B activation.

  17. Microclimatic performance of a free-air warming and CO₂ enrichment experiment in windy Wyoming, USA

    SciTech Connect (OSTI)

    LeCain, Daniel; Smith, David; Morgan, Jack; Kimball, Bruce A.; Pendall, Elise; Miglietta, Franco; Liang, Wenju

    2015-02-06

    In order to plan for global changing climate experiments are being conducted in many countries, but few have monitored the effects of the climate change treatments (warming, elevated CO₂) on the experimental plot microclimate. During three years of an eight year study with year-round feedback-controlled infra-red heater warming (1.5/3.0°C day/night) and growing season free-air CO₂ enrichment (600 ppm) in the mixed-grass prairie of Wyoming, USA, we monitored soil, leaf, canopy-air, above-canopy-air temperatures and relative humidity of control and treated experimental plots and evaluated ecologically important temperature differentials. Leaves were warmed somewhat less than the target settings (1.1 & 1.5°C day/night) but soil was warmed more creating an average that matched the target settings extremely well both during the day and night plus the summer and winter. The site typically has about 50% bare or litter covered soil, therefore soil heat transfer is more critical than in dense canopy ecosystems. The Wyoming site commonly has strong winds (5 ms⁻¹ average) and significant daily and seasonal temperature fluctuations (as much as 30°C daily) but the warming system was nearly always able to maintain the set temperatures regardless of abiotic variation. The within canopy-air was only slightly warmed and above canopy-air was not warmed by the system, therefore convective warming was minor. Elevated CO₂ had no direct effect nor interaction with the warming treatment on microclimate. Relative humidity within the plant canopy was only slightly reduced by warming. Soil water content was reduced by warming but increased by elevated CO₂. This study demonstrates the importance of monitoring the microclimate in manipulative field global change experiments so that critical physiological and ecological conclusions can be determined. Highly variable energy demand fluctuations showed that passive IR heater warming systems will not maintain desired warming for much

  18. Solute concentrations influence microbial methanogenesis in coal-bearing strata of the Cherokee basin, USA

    SciTech Connect (OSTI)

    Kirk, Matthew F.; Wilson, Brien H.; Marquart, Kyle A.; Zeglin, Lydia H.; Vinson, David S.; Flynn, Theodore M.

    2015-11-18

    In this study, microorganisms have contributed significantly to subsurface energy resources by converting organic matter in hydrocarbon reservoirs into methane, the main component of natural gas. In this study, we consider environmental controls on microbial populations in coal-bearing strata of the Cherokee basin, an unconventional natural gas resource in southeast Kansas, USA. Pennsylvanian-age strata in the basin contain numerous thin (0.4–1.1 m) coalbeds with marginal thermal maturities (0.5–0.7% Ro) that are interbedded with shale and sandstone. We collected gas, water, and microbe samples from 16 commercial coalbed methane wells for geochemical and microbiological analysis. The water samples were Na–Cl type with total dissolved solids (TDS) content ranging from 34.9 to 91.3 g L–1. Gas dryness values [C1/(C2 + C3)] averaged 2640 and carbon and hydrogen isotope ratios of methane differed from those of carbon dioxide and water, respectively, by an average of 65 and 183‰. These values are thought to be consistent with gas that formed primarily by hydrogenotrophic methanogenesis. Results from cultivation assays and taxonomic analysis of 16S rRNA genes agree with the geochemical results. Cultivable methanogens were present in every sample tested, methanogen sequences dominate the archaeal community in each sample (avg 91%), and few archaeal sequences (avg 4.2%) were classified within Methanosarcinales, an order of methanogens known to contain methylotrophic methanogens. Although hydrogenotrophs appear dominant, geochemical and microbial analyses both indicate that the proportion of methane generated by acetoclastic methanogens increases with the solute content of formation water, a trend that is contrary to existing conceptual models. Consistent with this trend, beta diversity analyses show that archaeal diversity significantly correlates with formation water solute content. In contrast

  19. Microclimatic performance of a free-air warming and CO₂ enrichment experiment in windy Wyoming, USA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    LeCain, Daniel; Smith, David; Morgan, Jack; Kimball, Bruce A.; Pendall, Elise; Miglietta, Franco; Liang, Wenju

    2015-02-06

    In order to plan for global changing climate experiments are being conducted in many countries, but few have monitored the effects of the climate change treatments (warming, elevated CO₂) on the experimental plot microclimate. During three years of an eight year study with year-round feedback-controlled infra-red heater warming (1.5/3.0°C day/night) and growing season free-air CO₂ enrichment (600 ppm) in the mixed-grass prairie of Wyoming, USA, we monitored soil, leaf, canopy-air, above-canopy-air temperatures and relative humidity of control and treated experimental plots and evaluated ecologically important temperature differentials. Leaves were warmed somewhat less than the target settings (1.1 & 1.5°C day/night)more » but soil was warmed more creating an average that matched the target settings extremely well both during the day and night plus the summer and winter. The site typically has about 50% bare or litter covered soil, therefore soil heat transfer is more critical than in dense canopy ecosystems. The Wyoming site commonly has strong winds (5 ms⁻¹ average) and significant daily and seasonal temperature fluctuations (as much as 30°C daily) but the warming system was nearly always able to maintain the set temperatures regardless of abiotic variation. The within canopy-air was only slightly warmed and above canopy-air was not warmed by the system, therefore convective warming was minor. Elevated CO₂ had no direct effect nor interaction with the warming treatment on microclimate. Relative humidity within the plant canopy was only slightly reduced by warming. Soil water content was reduced by warming but increased by elevated CO₂. This study demonstrates the importance of monitoring the microclimate in manipulative field global change experiments so that critical physiological and ecological conclusions can be determined. Highly variable energy demand fluctuations showed that passive IR heater warming systems will not maintain desired warming

  20. Safety Analysis Report for Packaging (SARP): Models AL-M3 and AL-M6 nuclear packaging (DOE C of C No. USA/5790/BLF and No. USA/5791/BLF)

    SciTech Connect (OSTI)

    Coleman, H.L.; Whitney, M.A.; Williams, M.A.; Alexander, B.M.; Shapiro, A.

    1987-11-24

    This revised Safety Analysis Report for Packaging (SARP) satisfies the requirement of the US Department of Energy (DOE) for an updated formal safety analysis of the two insulated drum shipping containers identified as USA/5790/BLF and USA/5791/BLF. The report makes available to all potential users the technical information and limits pertinent to the construction and use of the shipping containers. This SARP includes discussions of structural integrity, thermal resistance, radiation shielding and radiological safety, nuclear criticality safety, and quality control. Complete physical and technical descriptions of the packages are presented. Each package consists of a cylindrical steel inner container centered within an insulating steel drum assembly. The contents may be any radioactive materials that satisfy the requirements established in this SARP. A shipment of plutonium-238 in the form of a solid oxide is evaluated in this SARP as an example. Design and development considerations, the tests and evaluations required to prove the ability of the containers to withstand normal transportation conditions, and the sequence of four hypothetical accident conditions (free drop, puncture, thermal, and water immersion) are discussed. Tables, graphs, dimensional sketches, photographs, technical references, loading and shipping procedures, Mound Facility experience in using the containers, and copies of the DOE Certificates of Compliance are included.

  1. Epizootic ulcerative syndrome caused by Aphanomyces invadans in captive bullseye snakehead Channa marulius collected from south Florida, USA

    SciTech Connect (OSTI)

    Saylor, Ryan; Miller, Debra; Vandersea, Mark; Bevelhimer, Mark S; Schofield, Pamela; Bennett, Wayne

    2010-02-01

    Epizootic ulcerative syndrome (EUS) caused by the oomycete Aphanomyces invadans is an invasive, opportunistic disease of both freshwater and estuarine fishes. Originally documented as the cause of mycotic granulomatosis of ornamental fishes in Japan and as the cause of EUS of fishes in southeast Asia and Australia, this pathogen is also present in estuaries and freshwater bodies of the Atlantic and gulf coasts of the USA. We describe a mass mortality event of 343 captive juvenile bullseye snakehead Channa marulius collected from freshwater canals in Miami-Dade County, Florida. Clinical signs appeared within the first 2 d of captivity and included petechiae, ulceration, erratic swimming, and inappetence. Histological examination revealed hyphae invading from the skin lesions deep into the musculature and internal organs. Species identification was confirmed using a species-specific PCR assay. Despite therapeutic attempts, 100% mortality occurred. This represents the first documented case of EUS in bullseye snakehead fish collected from waters in the USA. Future investigation of the distribution and prevalence of A. invadans within the bullseye snakehead range in south Florida may give insight into this pathogen-host system.

  2. Venezuela-MEM/USA-DOE Fossil Energy Report IV-11: Supporting technology for enhanced oil recovery - EOR thermal processes

    SciTech Connect (OSTI)

    Venezuela

    2000-04-06

    This report contains the results of efforts under the six tasks of the Tenth Amendment anti Extension of Annex IV, Enhanced Oil Recovery Thermal Processes of the Venezuela/USA Energy Agreement. This report is presented in sections (for each of the six Tasks) and each section contains one or more reports that were prepared to describe the results of the effort under each of the Tasks. A statement of each Task, taken from the Agreement Between Project Managers, is presented on the first page of each section. The Tasks are numbered 68 through 73. The first through tenth report on research performed under Annex IV Venezuela MEM/USA-DOE Fossil Energy Report Number IV-1, IV-2, IV-3, IV-4, IV-5, IV-6, IV-7, IV-8, IV-9, IV-10 contain the results of the first 67 Tasks. These reports are dated April 1983, August 1984, March 1986, July 1987, November 1988, December 1989, October 1991, February 1993, March 1995, and December 1997, respectively.

  3. XL-A A.&lx A!i' X!Ii?Z IL';;i'

    Office of Legacy Management (LM)

    -- :I 9 .a # ** ,. . . m . . pJ;-,L' ,' i:-t.T .)r' yjs JzZ~ J~~;L,;.~;r 1:). 2 . m I;S~X:T ?I?. ::.:-25-::%-I.:.Glu~ XL-A A.&lx A!i' X!Ii?Z IL';;i' , X2,-d c i.XZEA?, th At3Ac Z:r.zr.~ f4z22s343n >q3 pquask$ tL,..- psg zd of &,-cc b&ldjmms: >UAeT; :,:,. &&;j L' *r: ! 3 ..m 3CCU"pxy &jJdbc ' Au ..3* 6u, I;..:; ' 2. CL&51, 1;; *-- l - l &j-2+; z5 a?, ft . IALP !13. f&%-i;& 2$&J 3;. ft.1 sq, ft.; &ii+ m* i.3. $+, hZE2X, it >a tmn

  4. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

    2013-11-15

    Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: Arsenite evokes IL-6 secretion. IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. Inflammation is involved in arsenite-induced EMT.

  5. IL Wted States Government

    Office of Legacy Management (LM)

    the building slab and small amounts of residual uranium in soil outside the building. ... EM-42 3. Wagoner, EM-421 W. A. Williams, EM-421 L. Price, OR -.- .-.. . .i y:-.

  6. Canada-USA Salmon Shelf Survival Study, 2007-2008 Annual Report.

    SciTech Connect (OSTI)

    Trudel, Marc; Tucker, Strahan; Morris, John

    2009-03-09

    Historically, salmon stocks from the Columbia River and Snake River formed one of the most valuable fisheries on the west coast of North America. However, salmon and steelhead returns sharply declined during the 1980s and 1990s to reach nearly 1 million fish. Although several factors may be responsible for the decline of Columbia River salmon and steelhead, there is increasing evidence that these drastic declines were primarily attributable to persistently unfavorable ocean conditions. Hence, an understanding of the effects of ocean conditions on salmon production is required to forecast the return of salmon to the Columbia River basin and to assess the efficacy of mitigation measures such as flow regulation on salmon resources in this system. The Canadian Program on High Seas Salmon has been collecting juvenile salmon and oceanographic data off the west coast of British Columbia and Southeast Alaska since 1998 to assess the effects of ocean conditions on the distribution, migration, growth, and survival of Pacific salmon. Here, we present a summary of the work conducted as part of the Canada-USA Salmon Shelf Survival Study during the 2008 fiscal year and compare these results with those obtained from previous years. The working hypothesis of this research is that fast growth enhances the marine survival of salmon, either because fast growing fish quickly reach a size that is sufficient to successfully avoid predators, or because they accumulate enough energy reserves to better survive their first winter at sea, a period generally considered critical in the life cycle of salmon. Sea surface temperature decreased from FY05 to FY08, whereas, the summer biomass of phytoplankton increased steadily off the west coast of Vancouver Island from FY05 to FY08. As in FY07, zooplankton biomass was generally above average off the west coast of Vancouver Island in FY08. Interestingly, phytoplankton and zooplankton biomass were higher in FY08 than was expected from the observed

  7. A Ten Step Protocol and Plan for CCS Site Characterization, Based on an Analysis of the Rocky Mountain Region, USA

    SciTech Connect (OSTI)

    McPherson, Brian; Matthews, Vince

    2013-09-15

    This report expresses a Ten-Step Protocol for CO2 Storage Site Characterization, the final outcome of an extensive Site Characterization analysis of the Rocky Mountain region, USA. These ten steps include: (1) regional assessment and data gathering; (2) identification and analysis of appropriate local sites for characterization; (3) public engagement; (4) geologic and geophysical analysis of local site(s); (5) stratigraphic well drilling and coring; (6) core analysis and interpretation with other data; (7) database assembly and static model development; (8) storage capacity assessment; (9) simulation and uncertainty assessment; (10) risk assessment. While the results detailed here are primarily germane to the Rocky Mountain region, the intent of this protocol is to be portable or generally applicable for CO2 storage site characterization.

  8. Superfund Record of Decision (EPA Region 3): USA Aberdeen, Operable Unit One, Michaelsville, MD. (Second remedial action), June 1992

    SciTech Connect (OSTI)

    Not Available

    1992-06-30

    The 20-acre USA Aberdeen Michaelsville Landfill is a municipal landfill located along the Chesapeake Bay in Harford County, Maryland. The site is in the northern portion of the Aberdeen Proving Ground (APG) in the Aberdeen Area (AA) between Michaelsville Road and Trench Warfare Road. The majority of materials reportedly disposed of at the site included domestic trash, trash from nonindustrial sources at APG, solvents, waste motor oils, PCB transformer oils, wastewater treatment sludges, pesticides containing thallium, insecticides containing selenium, and rodenticides containing antimony. The ROD addresses protection of the ground water by minimizing leachate flow and preventing current or future exposure to waste materials as the first of two OUs planned for the site. The primary contaminants of concern affecting the soil are organics, including pesticides; and metals, including chromium and lead.

  9. FUJIFILM Hunt Chemicals U.S.A. Achieves Compressed Air System Energy-Reduction Goals with a Three-Phased Strategy

    Broader source: Energy.gov [DOE]

    This case study describes how FUJIFILM Hunt Chemicals U.S.A. implemented a comprehensive, compressed air system energy-reduction strategy at its Dayton, Tennessee, manufacturing facility and saved more than 1,240,000 kilowatt hours of energy between 2008 and 2011.

  10. Celecoxib offsets the negative renal influences of cyclosporine via modulation of the TGF-?1/IL-2/COX-2/endothelin ET{sub B} receptor cascade

    SciTech Connect (OSTI)

    El-Gowelli, Hanan M.; Helmy, Maged W.; Ali, Rabab M.; El-Mas, Mahmoud M.

    2014-03-01

    Endothelin (ET) signaling provokes nephrotoxicity induced by the immunosuppressant drug cyclosporine A (CSA). We tested the hypotheses that (i): celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, counterbalances renal derangements caused by CSA in rats and (ii) the COX-2/endothelin ET{sub B} receptor signaling mediates the CSA-celecoxib interaction. Ten-day treatment with CSA (20 mg/kg/day) significantly increased biochemical indices of renal function (serum urea, creatinine), inflammation (interleukin-2, IL-2) and fibrosis (transforming growth factor-?{sub 1}, TGF-?{sub 1}). Histologically, CSA caused renal tubular atrophy along with interstitial fibrosis. These detrimental renal effects of CSA were largely reduced in rats treated concurrently with celecoxib (10 mg/kg/day). We also report that cortical glomerular and medullary tubular protein expressions of COX-2 and ET{sub B} receptors were reduced by CSA and restored to near-control values in rats treated simultaneously with celecoxib. The importance of ET{sub B} receptors in renal control and in the CSA-celecoxib interaction was further verified by the findings (i) most of the adverse biochemical, inflammatory, and histopathological profiles of CSA were replicated in rats treated with the endothelin ET{sub B} receptor antagonist BQ788 (0.1 mg/kg/day, 10 days), and (ii) the BQ788 effects, like those of CSA, were alleviated in rats treated concurrently with celecoxib. Together, the data suggest that the facilitation of the interplay between the TGF-?1/IL-2/COX-2 pathway and the endothelin ET{sub B} receptors constitutes the cellular mechanism by which celecoxib ameliorates the nephrotoxic manifestations of CSA in rats. - Highlights: Celecoxib abolishes nephrotoxic manifestations of CSA in rats. Blockade of ETB receptors by BQ788 mimicked the nephrotoxic effects of CSA. CSA or BQ788 reduces renal protein expression of COX-2 and endothelin ETB receptors. Enhanced TGF?1/IL-2/COX2/ETB signaling

  11. Effects of overstory composition and prescribed fire on fuel loading across a heterogeneous managed landscape in the southeastern USA.

    SciTech Connect (OSTI)

    Parresol, Bernard, R.; Scott, Joe, H.; Andreu, Anne; Prichard, Susan; Kurth, Laurie

    2012-01-01

    In the southeastern USA, land use history, forest management and natural geomorphic features have created heterogeneous fuel loads. This apparent temporal and spatial variation in fuel loads make it difficult to reliably assess potential fire behavior from remotely sensed canopy variables to determine risk and to prescribe treatments. We examined this variation by exploring the relationships between overstory forest vegetation attributes, recent fire history, and selected surface fuel components across an 80,000 ha contiguous landscape. Measurements of dead and live vegetation components of surface fuels were obtained from 624 permanent plots, or about 1 plot per 100 ha of forest cover. Within forest vegetation groups, we modeled the relationship between individual surface fuel components and overstory stand age, basal area, site quality and recent fire history, then stochastically predicted fuel loads across the landscape using the same linkage variables. The fraction of the plot variation, i.e., R2, explained by predictive models for individual fuel components ranged from 0.05 to 0.66 for dead fuels and 0.03 to 0.97 for live fuels in pine dominated vegetation groups. Stand age and basal area were generally more important than recent fire history for predicting fuel loads. Mapped fuel loads using these regressor variables showed a very heterogeneous landscape even at the scale of a few square kilometers. The mapped patterns corresponded to stand based forest management disturbances that are reflected in age, basal area, and fire history. Recent fire history was significant in explaining variation in litter and duff biomass. Stand basal area was positively and consistently related to dead fuel biomass in most groups and was present in many predictive equations. Patterns in live fuel biomass were related to recent fire history, but the patterns were not consistent among forest vegetation groups. Age and basal area were related to live fuels in a complex manner that

  12. Compatibility issues of potential payloads for the USA/9904/B(U)F-85 RTG transportation system (RTGTS) for the 'Pluto Express' mission

    SciTech Connect (OSTI)

    Miller, Roger G.; Barklay, Chadwick D.; Howell, Edwin I.; Frazier, Timothy A.

    1997-01-10

    The specific electric power system for the 'Pluto Express' mission has yet to be specified. However, electric power will be provided by either radioisotopic thermoelectric generators (RTG), radioisotope thermophotovoltaic systems (RTPV), alkali metal thermal to electrical conversion (AMTEC) systems, radioisotope Stirling systems, or a combination of these. The selected radioisotopic power system will also be transported using the USA/9904/B(U)F-85, Radioisotope Thermoelectric Generator (RTG) Transportation System (RTGTS). As a result, all of the potential payloads present uniquely different environmental and physical configuration requirements. This paper presents the major compatibility issues of the potential payloads for the USA/9904/B(U)F-85 RTG Transportation System for the 'Pluto Express' mission.

  13. Logistical concepts associated with international shipments using the USA/9904/B(U)F RTG Transportation System (RTGTS)

    SciTech Connect (OSTI)

    Barklay, C.D.; Miller, R.G.; Pugh, B.K.; Howell, E.I.

    1997-01-01

    Over the last 30 years, radioisotopes have provided heat from which electrical power is generated. For space missions, the isotope of choice has generally been {sup 238}PuO{sub 2}, its long half-life making it ideal for supplying power to remote satellites and spacecraft like the Voyager, Pioneer, and Viking missions, as well as the recently launched Galileo and Ulysses missions, and the presently planned Cassini mission. Electric power for future space missions will be provided by either radioisotopic thermoelectric generators (RTG), radioisotope thermophotovoltaic systems (RTPV), alkali metal thermal to electrical conversion (AMTEC) systems, radioisotope Stirling systems, or a combination of these. The type of electrical power system has yet to be specified for the {open_quotes}Pluto Express{close_quotes} mission. However, the current plan does incorporate the use of Russian launch platforms for the spacecraft. The implied tasks associated with this plan require obtaining international certification for the transport of the radioisotopic power system, and resolving any logistical issues associated with the actual shipment of the selected radioisotopic power system. This paper presents a conceptual summary of the logistical considerations associated with shipping the selected radioisotopic power system using the USA/9904/B(U)F-85, Radioisotope Thermoelectric Generator Transportation System (RTGTS). {copyright} {ital 1997 American Institute of Physics.}

  14. Logistical concepts associated with international shipments using the USA/9904/B(U)F RTG Transportation System (RTGTS)

    SciTech Connect (OSTI)

    Barklay, Chadwick D.; Miller, Roger G.; Pugh, Barry K.; Howell, Edwin I.

    1997-01-10

    Over the last 30 years, radioisotopes have provided heat from which electrical power is generated. For space missions, the isotope of choice has generally been {sup 238}PuO{sub 2}, its long half-life making it ideal for supplying power to remote satellites and spacecraft like the Voyager, Pioneer, and Viking missions, as well as the recently launched Galileo and Ulysses missions, and the presently planned Cassini mission. Electric power for future space missions will be provided by either radioisotopic thermoelectric generators (RTG), radioisotope thermophotovoltaic systems (RTPV), alkali metal thermal to electrical conversion (AMTEC) systems, radioisotope Stirling systems, or a combination of these. The type of electrical power system has yet to be specified for the 'Pluto Express' mission. However, the current plan does incorporate the use of Russian launch platforms for the spacecraft. The implied tasks associated with this plan require obtaining international certification for the transport of the radioisotopic power system, and resolving any logistical issues associated with the actual shipment of the selected radioisotopic power system. This paper presents a conceptual summary of the logistical considerations associated with shipping the selected radioisotopic power system using the USA/9904/B(U)F-85, Radioisotope Thermoelectric Generator Transportation System (RTGTS)

  15. Modeling of In-stream Tidal Energy Development and its Potential Effects in Tacoma Narrows, Washington, USA

    SciTech Connect (OSTI)

    Yang, Zhaoqing; Wang, Taiping; Copping, Andrea E.; Geerlofs, Simon H.

    2014-10-01

    Understanding and providing proactive information on the potential for tidal energy projects to cause changes to the physical system and to key water quality constituents in tidal waters is a necessary and cost-effective means to avoid costly regulatory involvement and late stage surprises in the permitting process. This paper presents a modeling study for evaluating the tidal energy extraction and its potential impacts on the marine environment in a real world site - Tacoma Narrows of Puget Sound, Washington State, USA. An unstructured-grid coastal ocean model, fitted with a module that simulates tidal energy devices, was applied to simulate the tidal energy extracted by different turbine array configurations and the potential effects of the extraction at local and system-wide scales in Tacoma Narrows and South Puget Sound. Model results demonstrated the advantage of an unstructured-grid model for simulating the far-field effects of tidal energy extraction in a large model domain, as well as assessing the near-field effect using a fine grid resolution near the tidal turbines. The outcome shows that a realistic near-term deployment scenario extracts a very small fraction of the total tidal energy in the system and that system wide environmental effects are not likely; however, near-field effects on the flow field and bed shear stress in the area of tidal turbine farm are more likely. Model results also indicate that from a practical standpoint, hydrodynamic or water quality effects are not likely to be the limiting factor for development of large commercial-scale tidal farms. Results indicate that very high numbers of turbines are required to significantly alter the tidal system; limitations on marine space or other environmental concerns are likely to be reached before reaching these deployment levels. These findings show that important information obtained from numerical modeling can be used to inform regulatory and policy processes for tidal energy development.

  16. Hydraulic Geometry and Microtopography of Tidal Freshwater Forested Wetlands and Implications for Restoration, Columbia River, U.S.A.

    SciTech Connect (OSTI)

    Diefenderfer, Heida L.; Coleman, Andre M.; Borde, Amy B.; Sinks, Ian A.

    2008-01-01

    The hydrologic reconnection of tidal channels, riverine floodplains, and main stem channels are among responses by ecological restoration practitioners to the increasing fragmentation and land conversion occurring in coastal and riparian zones. Design standards and monitoring of such ecological restoration depend upon the characterization of reference sites that vary within and among regions. Few locales, such as the 235 km tidal portion of the Columbia River on the West Coast U.S.A., remain in which the reference conditions and restoration responses of tidal freshwater forested wetlands on temperate zone large river floodplains can be compared. This study developed hydraulic geometry relationships for Picea sitchensis (Sitka spruce) dominated tidal forests (swamps) in the vicinity of Grays Bay on the Columbia River some 37 km from the Pacific Coast using field surveys and Light Detection and Ranging (LiDAR) data. Scaling relationships between catchment area and the parameters of channel cross-sectional area at outlet and total channel length were comparable to tidally influenced systems of San Francisco Bay and the United Kingdom. Dike breaching, culvert replacement, and tide gate replacement all affected channel cross-sectional geometry through changes in the frequency of over-marsh flows. Radiocarbon dating of buried wood provided evidence of changes in sedimentation rates associated with diking, and restoration trajectories may be confounded by historical subsidence behind dikes rendering topographical relationships with water level incomparable to reference conditions. At the same time, buried wood is influencing the development of channel morphology toward characteristics resembling reference conditions. Ecological restoration goals and practices in tidal forested wetland regions of large river floodplains should reflect the interactions of these controlling factors.

  17. Quantification of total mercury in liver and heart tissue of Harbor Seals (Phoca vitulina) from Alaska USA

    SciTech Connect (OSTI)

    Marino, Kady B. [Department of Chemistry, Roger Williams University, Bristol, RI 02809 (United States)] [Department of Chemistry, Roger Williams University, Bristol, RI 02809 (United States); Hoover-Miller, Anne; Conlon, Suzanne; Prewitt, Jill [Alaska SeaLife Center, City of Seward, AK (United States)] [Alaska SeaLife Center, City of Seward, AK (United States); O'Shea, Stephen K., E-mail: soshea@rwu.edu [Department of Chemistry, Roger Williams University, Bristol, RI 02809 (United States)

    2011-11-15

    This study quantified the Hg levels in the liver (n=98) and heart (n=43) tissues of Harbor Seals (Phoca vitulina) (n=102) harvested from Prince William Sound and Kodiak Island Alaska. Mercury tissue dry weight (dw) concentrations in the liver ranged from 1.7 to 393 ppm dw, and in the heart from 0.19 to 4.99 ppm dw. Results of this study indicate liver and heart tissues' Hg ppm dw concentrations significantly increase with age. Male Harbor Seals bioaccumulated Hg in both their liver and heart tissues at a significantly faster rate than females. The liver Hg bioaccumulation rates between the harvest locations Kodiak Island and Prince William Sound were not found to be significantly different. On adsorption Hg is transported throughout the Harbor Seal's body with the partition coefficient higher for the liver than the heart. No significant differences in the bio-distribution (liver:heart Hg ppm dw ratios (n=38)) values were found with respect to either age, sex or geographic harvest location. In this study the age at which Hg liver and heart bioaccumulation levels become significantly distinct in male and female Harbor Seals were identified through a Tukey's analysis. Of notably concern to human health was a male Harbor Seal's liver tissue harvested from Kodiak Island region. Mercury accumulation in this sample tissue was determined through a Q-test to be an outlier, having far higher Hg concentrarion (liver 392 Hg ppm dw) than the general population sampled. - Highlights: Black-Right-Pointing-Pointer Mercury accumulation in the liver and heart of seals exceed food safety guidelines. Black-Right-Pointing-Pointer Accumulation rate is greater in males than females with age. Black-Right-Pointing-Pointer Liver mercury accumulation is greater than in the heart tissues. Black-Right-Pointing-Pointer Mercury determination by USA EPA Method 7473 using thermal decomposition.

  18. An evaluation of health risk to the public as a consequence of in situ uranium mining in Wyoming, USA

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ruedig, Elizabeth; Johnson, Thomas E.

    2015-08-30

    In the United States there is considerable public concern regarding the health effects of in situ recovery uranium mining. These concerns focus principally on exposure to contaminants mobilized in groundwater by the mining process. However, the risk arising as a result of mining must be viewed in light of the presence of naturally occurring uranium ore and other constituents which comprise a latent hazard. The United States Environmental Protection Agency recently proposed new guidelines for successful restoration of an in situ uranium mine by limiting concentrations of thirteen groundwater constituents: arsenic, barium, cadmium, chromium, lead, mercury, selenium, silver, nitrate (asmore » nitrogen), molybdenum, radium, total uranium, and gross α activity. We investigated the changes occurring to these constituents at an ISR uranium mine in Wyoming, USA by comparing groundwater quality at baseline measurement to that at stability (post-restoration) testing. Of the groundwater constituents considered, only uranium and radium-226 showed significant (p < 0.05) deviation from site-wide baseline conditions in matched-wells. Uranium concentrations increased by a factor of 5.6 (95% CI 3.6–8.9 times greater) while radium-226 decreased by a factor of about one half (95% CI 0.42–0.75 times less). Change in risk was calculated using the RESRAD (onsite) code for an individual exposed as a resident-farmer; total radiation dose to a resident farmer decreased from pre-to post-mining by about 5.2 mSv y–1. As a result, higher concentrations of uranium correspond to increased biomarkers of nephrotoxicity, however the clinical significance of this increase is unclear.« less

  19. The Navajo scrubber project -- Start up and performance testing of the largest FGD system in the USA

    SciTech Connect (OSTI)

    Lusko, J.; Massion, R.; Sekhar, N.

    1998-07-01

    The Navajo Scrubber Project located in Page, Arizona is the largest Flue Gas Desulfurization (FGD) system in the USA. Limestone based FGD system producing disposable grade gypsum is being installed on Units 1,2 and 3 (3 x 750 MWe) at the Navajo Generating Station (NGS) to comply with an EPA ruling mandating SO{sub 2} emission reduction to improve visibility in the Grand Canyon National Park. Compliance will be phased-in by unit in 1997, 1998 and 1999. The NGS burns low-sulfur coal with a sulfur content of approximately 0.5%. The FGD system is designed to treat a total flue gas flow of 11.25 million acfm, at an SO{sub 2} removal efficiency of 92% for an emission of 0.1 lb. per million BTU. Unique features of the FGD system include, a totally closed loop water balance system, 775 ft. chimney with C-276 alloy clad designed to handle both wet and hot dry gas, solid C-276 alloy absorber vessels and the use of existing ID fans, with suitable modification, to overcome the additional pressure drop of the FGD system. The start-up sequence/operation and performance tests of Unit 3 of this unique FGD system is described in this paper. Performance tests include, removal efficiency determination at 0.6 and 0.8% sulfur coal at normal and 60,000 PPM chloride in the slurry, particulate carry over determination under normal as well as upset ESP conditions, and determination of mist eliminator carry-over using Video Droplet Analyzer.

  20. Energy Research Abstracts; (USA)

    SciTech Connect (OSTI)

    Rutkowski, R.W.; Henline, D.M.

    1991-01-01

    Energy Research Abstracts (ERA) provides abstracting and indexing coverage of all scientific and technical reports and patent applications originated by the US Department of Energy, its laboratories, energy centers, and contractors, as well as theses and conference papers and proceedings issued by these organizations in report form. Audiovisual materials, computer media (magnetic tapes, diskettes, etc.), and engineering drawings are included in this definition. ERA also covers other energy information prepared in report form by federal and state government organizations, foreign governments, and domestic and foreign universities and research organizations, provided that the full text of the document has been received by OSTI. Foreign report information is obtained through the International Energy Agency's fourteen nation Energy Technology Data Exchange, the International Atomic Energy Agency's International Nuclear Information System, or nation-to-nation agreements. The purpose of this publication is to announce documents produced or obtained by DOE that are not so readily available as journal articles, books, or patents. ERA does not cover nonreport literature. The scope of ERA encompasses DOE's research, development, demonstration, and technology programs resulting from its broad charter for energy sources, supplies, safety, environmental impacts, and regulation.

  1. Geothermal Energy; (USA)

    SciTech Connect (OSTI)

    Raridon, M.H.; Hicks, S.C.

    1991-01-01

    Geothermal Energy (GET) announces on a bimonthly basis the current worldwide information available on the technologies required for economic recovery of geothermal energy and its use as direct heat or for electric power production. This publication contains the abstracts of DOE reports, journal article, conference papers, patents, theses, and monographs added to the Energy Science and Technology Database (EDB) during the past two months. Also included are US information obtained through acquisition programs or interagency agreements and international information obtained through the International Energy Agency's Energy Technology Data Exchange or government-to-government agreements.

  2. Arlington, VA 22209 USA

    Office of Environmental Management (EM)

    Order 13563 should be to repeal its energy conservation standards for direct heating ... and industry support in education, statistics, government relations, marketing, ...

  3. Comparing large scale CCS deployment potential in the USA and China: a detailed analysis based on country-specific CO2 transport & storage cost curves

    SciTech Connect (OSTI)

    Dahowski, Robert T.; Davidson, Casie L.; Dooley, James J.

    2011-04-18

    The United States and China are the two largest emitters of greenhouse gases in the world and their projected continued growth and reliance on fossil fuels, especially coal, make them strong candidates for CCS. Previous work has revealed that both nations have over 1600 large electric utility and other industrial point CO2 sources as well as very large CO2 storage resources on the order of 2,000 billion metric tons (Gt) of onshore storage capacity. In each case, the vast majority of this capacity is found in deep saline formations. In both the USA and China, candidate storage reservoirs are likely to be accessible by most sources with over 80% of these large industrial CO2 sources having a CO2 storage option within just 80 km. This suggests a strong potential for CCS deployment as a meaningful option to efforts to reduce CO2 emissions from these large, vibrant economies. However, while the USA and China possess many similarities with regards to the potential value that CCS might provide, including the range of costs at which CCS may be available to most large CO2 sources in each nation, there are a number of more subtle differences that may help us to understand the ways in which CCS deployment may differ between these two countries in order for the USA and China to work together - and in step with the rest of the world - to most efficiently reduce greenhouse gas emissions. This paper details the first ever analysis of CCS deployment costs in these two countries based on methodologically comparable CO2 source and sink inventories, economic analysis, geospatial source-sink matching and cost curve modeling. This type of analysis provides a valuable insight into the degree to which early and sustained opportunities for climate change mitigation via commercial-scale CCS are available to the two countries, and could facilitate greater collaboration in areas where those opportunities overlap.

  4. Bioreduction and immobilization of uranium in situ: a case study at a USA Department of Energy radioactive waste site, Oak Ridge, Tennessee

    SciTech Connect (OSTI)

    Wu, Weimin; Carley, Jack M; Watson, David B; Gu, Baohua; Brooks, Scott C; Kelly, Shelly D; Kemner, Kenneth M; Van Nostrand, Joy; Wu, Liyou; Zhou, Jizhong; Luo, Jian; Cardenas, Erick; Fields, Matthew Wayne; Marsh, Terence; Tiedje, James; Green, Stefan; Kostka, Joel; Kitanidis, Peter K.; Jardine, Philip; Criddle, Craig

    2011-01-01

    Bioremediation of uranium contaminated groundwater was tested by delivery of ethanol as an electron donor source to stimulate indigenous microbial bioactivity for reduction and immobilization of uranium in situ, followed by tests of stability of uranium sequestration in the bioreduced area via delivery of dissolved oxygen or nitrate at the US Department of energy's Integrated Field Research Challenge site located at Oak Ridge, Tennessee, USA. After long term treatment that spanned years, uranium in groundwater was reduced from 40-60 mg {center_dot} L{sup -1} to <0.03 mg {center_dot} L{sup -1}, below the USA EPA standard for drinking water. The bioreduced uranium was stable under anaerobic or anoxic conditions, but addition of DO and nitrate to the bioreduced zone caused U remobilization. The change in the microbial community and functional microorganisms related to uranium reduction and oxidation were characterized. The delivery of ethanol as electron donor stimulated the activities of indigenous microorganisms for reduction of U(VI) to U(IV). Results indicated that the immobilized U could be partially remobilized by D0 and nitrate via microbial activity. An anoxic environmental condition without nitrate is essential to maintain the stability of bioreduced uranium.

  5. The form, distribution and mobility of arsenic in soilscontaminated by arsenic trioxide, at sites in southeast USA

    SciTech Connect (OSTI)

    Yang, Li; Donahoe, Rona J.

    2005-03-04

    Soils from many industrial sites in southeastern USA arecontaminated with As because of the application of herbicide containingAs2O3. Among those contaminated sites, two industrial sites, FW and BH,which are currently active and of most serious environmental concerns,were selected to characterize the occurrence of As in the contaminatedsoils and to evaluate its environmental leachability. The soils are bothsandy loams with varying mineralogical and organic matter contents.Microwave-assisted acid digestion (EPA method 3051) of the contaminatedsoils indicated As levels of up to 325 mg/kg and 900 mg/kg (dry weightbasis) for FW and BH soils, respectively. However, bulk X-ray powderdiffraction (XRD) analysis failed to find any detectable As-bearingphases in either of the studied soil samples. Most of the soil As wasobserved by scanning electron microscopy, coupled with energy dispersiveX-ray spectroscopy (SEM/EDX), to be disseminated on the surfaces offine-grained soil particles in close association with Al and Fe. A fewAs-bearing particles were detected in BH soil using electron microprobeanalysis (EMPA). Synchrotron micro-XRD and X-ray absorption near-edgestructure (XANES) analyses indicated that these As-rich particles werepossibly phaunouxite, a mineral similar to calcium arsenate, which couldhave been formed by natural weathering after the application of As2O3.However, the scarcity of those particles eliminated them from playing anyimportant role in Assequestration.Synthetic acid rain sequential batchleaching experiments showed distinct As leaching behaviors of the twostudied soil samples: BH soil, which has the higher As content, showed aslow, steady release of As, while FW soil, with a lower As content,showed a much quicker release and lower overall retention of As uponleaching. Sequential chemical extraction experiments were carried outusing a simplified 4-step sequential chemical extraction procedure (SCEP)previously developed to characterize the fractionation

  6. TGF-{beta}1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-{kappa}B/IL-6/MMP-2

    SciTech Connect (OSTI)

    Binker, Marcelo G.; CBRHC Research Center, Buenos Aires ; Binker-Cosen, Andres A.; Gaisano, Herbert Y.; Cosen, Rodica H. de; Cosen-Binker, Laura I.

    2011-02-04

    Research highlights: {yields} Rac1 mediates TGF-{beta}1-induced SW1990 invasion through MMP-2 secretion and activation. {yields} NADPH-generated ROS act downstream of Rac1 in TGF-{beta}1-challenged SW1990 cells. {yields} TGF-{beta}1-stimulated ROS activate NF-{kappa}B in SW1990 cells. {yields} NF{kappa}B-induced IL-6 release is required for secretion and activation of MMP-2 in SW1990 cells. -- Abstract: Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-{beta}1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic cancer cell types. In the present study, we investigated the signaling pathway involved in TGF-{beta}1-promoted MMP-2 secretion and invasion by human pancreatic cancer cells SW1990. Using specific inhibitors, we found that stimulation of these tumor cells with TGF-{beta}1 induced secretion and activation of the collagenase MMP-2, which was required for TGF-{beta}1-stimulated invasion. Our results also indicate that signaling events involved in TGF-{beta}1-enhanced SW1990 invasiveness comprehend activation of Rac1 followed by generation of reactive oxygen species through nicotinamide adenine dinucleotide phosphate-oxidase, activation of nuclear factor-kappa beta, release of interleukin-6, and secretion and activation of MMP-2.

  7. Microsoft Word - IAEA moment paper-1.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of California, Los Angeles, CA USA 3) Wheaton College, Wheaton, IL USA email: scprager@wisc.edu Abstract. In the MST reversed field pinch the radial profile of the plasma rotation...

  8. SREL Reprint #3288

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 Retention and chemical speciation of uranium in an oxidized wetland sediment from the ... Chicago, IL 60637, USA Abstract: Uranium speciation and retention mechanisms onto ...

  9. SREL Reprint #3242

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Participation, Environmental and Occupational Health Sciences Institute, Piscataway, ... IL, USA 4Environmental and Community Medicine, UMDNJ-Robert Wood Johnson Medical ...

  10. Overview of the integration and operation of the USA/9904/B(U)F-85 RTG transportation system (RTGTS) for Cassini and future missions

    SciTech Connect (OSTI)

    Miller, R.G.

    1997-01-01

    The USA/9904/B(U)F-85, Radioisotope Thermoelectric Generator (RTG) Transportation System (RTGTS) was designed and tested by Westinghouse Hanford Company but was transferred to EG&G Mound Applied Technologies to transport Radioisotope Thermoelectric Generators (RTGs) in support of the Cassini mission. EG&G Mound Applied Technologies is also the RTGTS custodian. Since the RTGTS is a new system, careful scrutiny must be applied not only to the integration of the system into Mound{close_quote}s operations but also the operation of the system so as to prevent any adverse affects to the performance of the RTGs. This paper details specific precautions that have been applied to the integration and operation of the RTGTS to protect the Cassini RTGs during loading, onloading, transportation, offloading, and unloading. {copyright} {ital 1997 American Institute of Physics.}