Sample records for traumatic brain injury

  1. Traumatic brain injury with particular reference to diffuse traumatic axonal injury subpopulations 

    E-Print Network [OSTI]

    Al-Hasani, Omer Hussain

    2011-07-05T23:59:59.000Z

    Traumatic brain injury (TBI) remains an important cause of morbidity and mortality within society. TBI may result in both focal and diffuse brain injury. Diffuse traumatic axonal injury (TAI) is an important pathological substrate of TBI, and can...

  2. Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms in OEF/OIF Veterans : : A Combined Diffusion Tensor Imaging and Cortical Thickness Study

    E-Print Network [OSTI]

    Sorg, Scott Francis

    2013-01-01T23:59:59.000Z

    injury in mild traumatic brain injury: A diffusion tensoralteration after traumatic brain injury experienced duringE. (1999). Mild traumatic brain injury. Neuropsychological

  3. Understanding Why Patients Return to the Emergency Department after Mild Traumatic Brain Injury within 72 Hours

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    patients with minimal brain injury and small intracranialelements for traumatic brain injury: a population study. Intcenter for mild traumatic brain injury. Neurosurgical Focus.

  4. Quantitative Brain Electrical Activity in the Initial Screening of Mild Traumatic Brain Injuries

    E-Print Network [OSTI]

    O'Neil, Brian; Prichep, Leslie S.; Naunheim, Roseanne; Chabot, Robert

    2012-01-01T23:59:59.000Z

    investigation into mild brain injury and discriminantfrequency bands (32-64 Hz). Brain Inj. 24. Thakor NV, Tongfor accuracy traumatic brain injury. J Neuropsychiatry Clin

  5. Traumatic Brain Injury Dr Seena Fazel & Prof. Huw Williams

    E-Print Network [OSTI]

    Mumby, Peter J.

    Traumatic Brain Injury and Crime Dr Seena Fazel & Prof. Huw Williams NHS Centre for Clinical Neuropsychological Research (CCNR) #12;Traumatic Brain Injury (TBI) Moderate-Severe TBI (e.g. 30 mins + LoC) ­ insult to the brain from an external mechanical force. ­ E.g. blow to the head - "fast- stop" in a crash

  6. Computational Simulation and Visualization of Traumatic Brain Injuries

    E-Print Network [OSTI]

    Burtscher, Martin

    brain tissue oscillations shed new light on the mechanisms of Closed Head Injuries. Our results may helpComputational Simulation and Visualization of Traumatic Brain Injuries Martin Burtscher School the human brain dynamics in realistic 2D cross-sections during trau- matic scenarios corresponding

  7. Routine Repeat Head CT may not be Indicated in Patients on Anticoagulant/Antiplatelet Therapy Following Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    McCammack, Kevin C.; Sadler, Charlotte; Guo, Yueyang; Ramaswamy, Raja S; Farid, Nikdokht

    2015-01-01T23:59:59.000Z

    and an intracranial bleed. J Trauma. brain injury deaths andFollowing Mild Traumatic Brain Injury Kevin C. McCammack,after mild traumatic brain injury (TBI) are controversial.

  8. Trajectories of Life Satisfaction During the First 10 Years Following Traumatic Brain Injury

    E-Print Network [OSTI]

    Williamson, Meredith

    2014-05-23T23:59:59.000Z

    To examine the predictive relationships of functional ability, gender, and age on the longitudinal trajectories of life satisfaction across 10 years following onset of traumatic brain injury (TBI). Participants were part of the Traumatic Brain...

  9. Transcranial LED therapy for cognitive dysfunction in chronic, mild traumatic brain injury: Two case reports

    E-Print Network [OSTI]

    Hamblin, Michael R.

    Two chronic, traumatic brain injury (TBI) cases are presented, where cognitive function improved following treatment with transcranial light emitting diodes (LEDs). At age 59, P1 had closed-head injury from a motor vehicle ...

  10. Fluid-filled helmet liner concept for protection against blast-induced traumatic brain injury

    E-Print Network [OSTI]

    Yost, Allison L. (Allison Lynne)

    2012-01-01T23:59:59.000Z

    Due to changes in modem warfare threats, as well as advances in body armor, soldier survivability in combat has increased, but blast-induced Traumatic Brain Injury (TBI) has become a prevalent injury in the battlefield. ...

  11. Design of a composite combat helmet liner for prevention of blast-induced traumatic brain injury

    E-Print Network [OSTI]

    Vechart, Andrew (Andrew Peter)

    2011-01-01T23:59:59.000Z

    Air blast-induced traumatic brain injuries (TBIs) represent a significant percentage of military personnel injuries observed in Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF). Prevalence of blast-induced ...

  12. Post-Traumatic Stress Disorder (PTSD) Symptoms as Predictors of Suicide Behavior Among Veterans with and without a History of Traumatic Brain Injury (TBI)

    E-Print Network [OSTI]

    Villarreal, Edgar Javier

    2012-10-19T23:59:59.000Z

    POST-TRAUMATIC STRESS DISORDER (PTSD) SYMPTOMS AS PREDICTORS OF SUICIDE BEHAVIOR AMONG VETERANS WITH AND WITHOUT A HISTORY OF TRAUMATIC BRAIN INJURY (TBI) A Dissertation by EDGAR JAVIER VILLARREAL Submitted to the Office...-Traumatic Stress Disorder (PTSD) Symptoms as Predictors of Suicide Behavior among Veterans with and without a History of Traumatic Brain Injury (TBI) Copyright 2012 Edgar Javier Villarreal POST-TRAUMATIC STRESS DISORDER (PTSD) SYMPTOMS AS PREDICTORS...

  13. Technical Aspects of an Impact Acceleration Traumatic Brain Injury Rat Model with Potential Suitability for both Microdialysis and PtiO2

    E-Print Network [OSTI]

    Boyer, Edmond

    molecules are now conceivable to ameliorate severe head-injury treatment. Keywords: Traumatic Brain Injury of anaesthesia and/or neuroprotection, a traumatic brain injury (TBI) animal model, similar to human head injury1 Technical Aspects of an Impact Acceleration Traumatic Brain Injury Rat Model with Potential

  14. Improved Cognitive Function After Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports

    E-Print Network [OSTI]

    Naeser, Margaret A.

    Objective: Two chronic, traumatic brain injury (TBI) cases, where cognition improved following treatment with red and near-infrared light-emitting diodes (LEDs), applied transcranially to forehead and scalp areas, are ...

  15. The changing landscape of traumatic brain injury research As thisissue of The Lancet Neurology went to press, the guidelines for the management of patients in different

    E-Print Network [OSTI]

    Neurology went to press, the guidelines for the management of patients in different traumatic brain injury clinical Brain Injury Research(InTBIR).This initiative, whichwill trials. Hence, approaches to measure

  16. Computational modeling of blast-induced traumatic brain injury

    E-Print Network [OSTI]

    Nyein, Michelle K. (Michelle Kyaw)

    2010-01-01T23:59:59.000Z

    Blast-induced TBI has gained prominence in recent years due to the conflicts in Iraq and Afghanistan, yet little is known about the mechanical effects of blasts on the human head; no injury thresholds have been established ...

  17. Distinguishing Realistic Military Blasts from Firecrackers in Mitigation Studies of Blast Induced Traumatic Brain Injury

    SciTech Connect (OSTI)

    Moss, W C; King, M J; Blackman, E G

    2011-01-21T23:59:59.000Z

    In their Contributed Article, Nyein et al. (1,2) present numerical simulations of blast waves interacting with a helmeted head and conclude that a face shield may significantly mitigate blast induced traumatic brain injury (TBI). A face shield may indeed be important for future military helmets, but the authors derive their conclusions from a much smaller explosion than typically experienced on the battlefield. The blast from the 3.16 gm TNT charge of (1) has the following approximate peak overpressures, positive phase durations, and incident impulses (3): 10 atm, 0.25 ms, and 3.9 psi-ms at the front of the head (14 cm from charge), and 1.4 atm, 0.32 ms, and 1.7 psi-ms at the back of a typical 20 cm head (34 cm from charge). The peak pressure of the wave decreases by a factor of 7 as it traverses the head. The blast conditions are at the threshold for injury at the front of the head, but well below threshold at the back of the head (4). The blast traverses the head in 0.3 ms, roughly equal to the positive phase duration of the blast. Therefore, when the blast reaches the back of the head, near ambient conditions exist at the front. Because the headform is so close to the charge, it experiences a wave with significant curvature. By contrast, a realistic blast from a 2.2 kg TNT charge ({approx} an uncased 105 mm artillery round) is fatal at an overpressure of 10 atm (4). For an injury level (4) similar to (1), a 2.2 kg charge has the following approximate peak overpressures, positive phase durations, and incident impulses (3): 2.1 atm, 2.3 ms, and 18 psi-ms at the front of the head (250 cm from charge), and 1.8 atm, 2.5 ms, and 16.8 psi-ms at the back of the head (270 cm from charge). The peak pressure decreases by only a factor of 1.2 as it traverses the head. Because the 0.36 ms traversal time is much smaller than the positive phase duration, pressures on the head become relatively uniform when the blast reaches the back of the head. The larger standoff implies that the headform locally experiences a nearly planar blast wave. Also, the positive phase durations and blast impulses are much larger than those of (1). Consequently, the blast model used in (1) is spatially and temporally very different from a military blast. It would be useful to repeat the calculations using military blast parameters. Finally, (1) overlooks a significant part of (5). On page 1 and on page 3, (1) states that (5) did not consider helmet pads. But pages pages 3 and 4 of (5) present simulations of blast wave propagation across an ACH helmeted head form with and without pads. (5) states that when the pads are present, the 'underwash' of air under the helmet is blocked when compared to the case without. (1) reaches this same conclusion, but reports it as a new result rather than a confirmation of that already found in (5).

  18. Modeling and simulation of blast-induced, early-time intracranial wave physics leading to traumatic brain injury.

    SciTech Connect (OSTI)

    Ford, Corey C. (University of New Mexico, Albuquerque, NM); Taylor, Paul Allen

    2008-02-01T23:59:59.000Z

    The objective of this modeling and simulation study was to establish the role of stress wave interactions in the genesis of traumatic brain injury (TBI) from exposure to explosive blast. A high resolution (1 mm{sup 3} voxels), 5 material model of the human head was created by segmentation of color cryosections from the Visible Human Female dataset. Tissue material properties were assigned from literature values. The model was inserted into the shock physics wave code, CTH, and subjected to a simulated blast wave of 1.3 MPa (13 bars) peak pressure from anterior, posterior and lateral directions. Three dimensional plots of maximum pressure, volumetric tension, and deviatoric (shear) stress demonstrated significant differences related to the incident blast geometry. In particular, the calculations revealed focal brain regions of elevated pressure and deviatoric (shear) stress within the first 2 milliseconds of blast exposure. Calculated maximum levels of 15 KPa deviatoric, 3.3 MPa pressure, and 0.8 MPa volumetric tension were observed before the onset of significant head accelerations. Over a 2 msec time course, the head model moved only 1 mm in response to the blast loading. Doubling the blast strength changed the resulting intracranial stress magnitudes but not their distribution. We conclude that stress localization, due to early time wave interactions, may contribute to the development of multifocal axonal injury underlying TBI. We propose that a contribution to traumatic brain injury from blast exposure, and most likely blunt impact, can occur on a time scale shorter than previous model predictions and before the onset of linear or rotational accelerations traditionally associated with the development of TBI.

  19. Molecular mechanisms of traumatic brain injury; the missing link in management

    E-Print Network [OSTI]

    Veenith, Tonny; Goon, Serena H; Burnstein, Rowan M

    2009-02-02T23:59:59.000Z

    family of cysteine pro- teases [including interleukin-1? converting enzyme (ICE) and cpp32] and a family of genes that are homologous to the oncogene Bcl-2 that either promote or suppress cell death. The Bcl-2 gene family controls both caspase dependent... with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26(4):239-57. 25. Rink A, Fung KM, Trojanowski JQ, Lee VM, Neugebauer E, McIntosh TK: Evidence of apoptotic cell death after experimental trau- matic brain injury in the rat. Am J Pathol...

  20. Increased Blood Glucose is Related to Disturbed Cerebrovascular Pressure Reactivity After Traumatic Brain Injury

    E-Print Network [OSTI]

    Donnelly, Joseph; Sudhan, Nazneen; Varsos, Georgios V.; Nasr, Nathalie; Jalloh, Ibrahim; Liu, Xiuyun; Dias, Celeste; Sekhon, Mypinder; Carpenter, Keri L. H.; Menon, David K.; Hutchinson, Peter J.; Smielewski, Peter; Czosnyka, Marek

    2014-08-15T23:59:59.000Z

    of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada 6 Institute of Electronic Systems, Warsaw University of Technology, Warsaw, Poland Running title: Glucose and pressure reactivity after traumatic... acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology. J Cereb Blood Flow Metab 1981;1:297–311. 7. Diaz-Parejo P, Ståhl N, Xu W, Reinstrup P, Ungerstedt U, Nordström C-H. Cerebral energy metabolism during transient hyperglycemia...

  1. MODELING INTRACRANIAL FLUID FLOWS AND VOLUMES DURING TRAUMATIC BRAIN INJURY TO BETTER UNDERSTAND PRESSURE

    E-Print Network [OSTI]

    , and pressure associated with each intra- and extracranial compartment (arteries and arterioles, capillary bed fluid volume] + ["other" volume]) is fixed [7]. Excellent mathematical results and insights, the assumption of fixed brain volume is not ac

  2. Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings

    E-Print Network [OSTI]

    Jalloh, Ibrahim; Carpenter, Keri L. H.; Helmy, Adel; Carpenter, T. Adrian; Menon, David K.; Hutchinson, Peter J.

    2014-11-21T23:59:59.000Z

    . These reactions are essentially irreversible whereas the other enzymatic steps exist in equilibrium. Pyruvate is converted to acetyl CoA, which enters the tricarboxylic acid (TCA) cycle, within mitochondria. The TCA cycle results in the transfer of electrons (from... substrates potentially metabolised by the injured brain that would in theory account for an MR greater than 6 include lactate (see below) and ketone bodies (Prins and Giza 2006). Further non-glucose substrates for brain could include fatty acids, although a...

  3. acute traumatic spinal: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TRAUMATIC BRAIN INJURY USING 4D MODELING OF LONGITUDINAL MRI Bo and treatment efficacy in patients with traumatic brain injury (TBI). To our knowledge, the identification, School...

  4. acute traumatic brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    traumatic brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Acute Injury Phase Clinical Trials in...

  5. Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus–CSF nexus

    E-Print Network [OSTI]

    Johanson, Conrad; Stopa, Edward; Baird, Andrew; Sharma, Hari

    2011-01-01T23:59:59.000Z

    re?ects trauma sequelae in brain. S100B has also been testedhyperthermia challenges to brain when delivered to CNS viaeffectively protects the brain against edema (Naka- machi et

  6. Understanding Why Patients Return to the Emergency Department after Mild Traumatic Brain Injury within 72 hours of Discharge

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    a bleed on head computed tomography (CT) (p=0.0334). EDafter injury. A computed tomography (CT) was performed indepartment; CT, computed tomography Western Journal of

  7. alkali burn traumatic: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (TBI). The goal of the current study was to assess: Performance monitoring, traumatic brain injury, children, head injury, neuropsychology, pediatrics. Traumatic Logan, Gordon...

  8. EXCELLENTIA CoLumbIA ENgINEErINg22 eople suffering from brain diseases and conditions ranging from traumatic brain

    E-Print Network [OSTI]

    Hone, James

    HEALTH EXCELLENTIA CoLumbIA ENgINEErINg22 P eople suffering from brain diseases and conditions ranging from traumatic brain injury to brain cancer to progressive brain disorders could be helped if therapeu- tic drugs could be easily delivered to the affected areas. The blood-brain barrier (BBB

  9. Social Work Delivered Intervention for Persons with Mild Traumatic Brain Injury: Implementation and Evaluation in an Urban, Public, Trauma Center Emergency Department

    E-Print Network [OSTI]

    Moore, Megan

    2012-01-01T23:59:59.000Z

    fatal injuries. Medical advances of this magnitude areof success” (p. 3). Medical advances treat the injury orConcurrently, advances in armor and battlefield medical care

  10. acute arterial injury: Topics by E-print Network

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    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  11. acute tracheobronchial injury: Topics by E-print Network

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    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  12. acute crush injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  13. acute thermal injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  14. acute tubular injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  15. acute glomerular injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  16. acute neural injury: Topics by E-print Network

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    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  17. acute myocardial injury: Topics by E-print Network

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    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  18. acute radiation injuries: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  19. acute irradiation injury: Topics by E-print Network

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    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  20. acute phase injury: Topics by E-print Network

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    Next Page Last Page Topic Index 1 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  1. acute radiation injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  2. acute colonic injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acute kidney Bushman, Frederic 2 Acute Injury Phase Clinical Trials in Acute Traumatic Brain Injury Engineering Websites Summary: 6122013 1 Acute Injury Phase Clinical Trials in...

  3. Use of diffusion tensor imaging to assess the impact of normobaric hyperoxia within at-risk pericontusional tissue after traumatic brain injury

    E-Print Network [OSTI]

    Veenith, Tonny V.; Carter, Eleanor L.; Grossac, Julia; Newcombe, Virginia F.; Outtrim, Joanne G.; Nallapareddy, Sridhar; Lupson, Victoria; Correia, Marta M.; Mada, Marius M.; Williams, Guy B.; Menon, David K.; Coles, Jonathan P.

    2014-07-09T23:59:59.000Z

    Glamorgan, Wales, UK). Diffusion tensor imaging was obtained at each level after an equilibration period of 15min to assess the impact of oxygen therapy on normal brain. Imaging All subjects were scanned using a 3T Siemens Verio magnetic resonance imaging... scanner (Siemens AG, Erlangen, Germany) within the Wolfson Brain Imaging Centre (WBIC), University of Cambridge. During the study period there were no major changes or upgrades to the scanner or software. The sequences obtained were structural sequences...

  4. Use of diffusion tensor imaging to assess the impact of normobaric hyperoxia within at-risk pericontusional tissue following traumatic brain injury

    E-Print Network [OSTI]

    Veenith, T.V.; Carter, E.L.; Grossac, J.; Newcombe, V.F.; Outtrim, J.G.; Nallapareddy, Sridhar; Lupson, Victoria; Correia, M.M.; Mada, Marius M.; Williams, Guy B.; Menon, David K.; Coles, J.P.

    2014-07-08T23:59:59.000Z

    Glamorgan, Wales, UK). Diffusion tensor imaging was obtained at each level after an equilibration period of 15min to assess the impact of oxygen therapy on normal brain. Imaging All subjects were scanned using a 3T Siemens Verio magnetic resonance imaging... scanner (Siemens AG, Erlangen, Germany) within the Wolfson Brain Imaging Centre (WBIC), University of Cambridge. During the study period there were no major changes or upgrades to the scanner or software. The sequences obtained were structural sequences...

  5. European Society of Intensive Care Medicine study of therapeutic hypothermia (32-35degreesC) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)

    E-Print Network [OSTI]

    Andrews, Peter J D; Sinclair, Helen Louise K; Battison, Claire G; Polderman, Kees K; Citerio, Giuseppe K; Mascia, Luciana K; Harris, Bridget A; Murray, Gordon D; Stocchetti, Nino K; Menon, David K; Shakur, Haleema K; De Backer, Daniel K; Eurotherm3235Trial Collaborators

    2011-01-12T23:59:59.000Z

    >20 mmHg for ?5 minutes after first line treatments with no obvious reversible cause e.g. patient position, coughing, inadequate sedation 4) ?72 hours from the initial head injury 5) Cooling device or technique available for >48 hours 6) Core...

  6. Numerical Modeling of Brain Dynamics in Traumatic Situations -Impulsive Translations

    E-Print Network [OSTI]

    Burtscher, Martin

    .S.A. Abstract We numerically model the brain dy- namics during and after impulsive head translations using brain injuries appear among boxers and shaken babies despite minimal rotations of their heads. Modeling head translations also helps understand the brain dynamics during head rotations about an arbitrary

  7. Computational Methods for Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    Bianchi, Anthony Christopher

    2014-01-01T23:59:59.000Z

    a second craniotomy and mCCI was induced on the leftcontrolled cortical impact (mCCI) [45][6]. In the CCI model3mm posterior to bregma) and a mCCI is induced using an

  8. Skull Flexure from Blast Waves: A Mechanism for Brain Injury with Implications for Helmet Design

    SciTech Connect (OSTI)

    Moss, W C; King, M J; Blackman, E G

    2009-04-30T23:59:59.000Z

    Traumatic brain injury [TBI] has become a signature injury of current military conflicts, with debilitating, costly, and long-lasting effects. Although mechanisms by which head impacts cause TBI have been well-researched, the mechanisms by which blasts cause TBI are not understood. From numerical hydrodynamic simulations, we have discovered that non-lethal blasts can induce sufficient skull flexure to generate potentially damaging loads in the brain, even without a head impact. The possibility that this mechanism may contribute to TBI has implications for injury diagnosis and armor design.

  9. Woodpecker pecking: how woodpeckers avoid brain injury

    E-Print Network [OSTI]

    Gibson, Lorna

    Woodpeckers are capable of repeated pecking on a tree at remarkably high decelerations (on the order of 10 000 m s?2 or 1000 g). In this paper, I re-examine previous studies of pecking and scaling effects in brain injury. ...

  10. Skull flexure from blast waves: a mechanism for brain injury with implications for helmet design

    SciTech Connect (OSTI)

    Moss, W C; King, M J; Blackman, E G

    2009-04-14T23:59:59.000Z

    Traumatic brain injury [TBI] has become a signature injury of current military conflicts. The debilitating effects of TBI are long-lasting and costly. Although the mechanisms by which impacts cause TBI have been well researched, the mechanisms by which blasts cause TBI are not understood. Various possibilities have been investigated, but blast-induced deformation of the skull has been neglected. From numerical hydrodynamic simulations, we have discovered that nonlethal blasts can induce sufficient flexure of the skull to generate potentially damaging loads in the brain, even if no impact occurs. The possibility that this mechanism may contribute to TBI has implications for the diagnosis of soldiers and the design of protective equipment such as helmets.

  11. acute post-traumatic brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    post-traumatic brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Attentional functioning in...

  12. acute brain injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    acute brain injury First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Acute Injury Phase Clinical Trials...

  13. Using biomarkers to identify traumatic brain injury for soldiers...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    leaders recognized that LANL technologies such as the waveguide biosensor and associated measurement technologies might be applied to TBI. Samitaur Medical Technologies' chief...

  14. Traumatic Brain Injury Protection: Blast Pressure Sensors in Helmets -

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2,EHSS A-Z Site Map Organization Chart

  15. Using biomarkers to identify traumatic brain injury for soldiers, sports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening aTurbulence mayUndergraduateAboutUserHadoop SCP/SFTPfigures

  16. Volume 10, No. 1 Decade of the Brain

    E-Print Network [OSTI]

    Dolbow, John

    Winter 2014 Volume 10, No. 1 SHINING A LIGHT ON BRAIN INJURY Decade of the Brain #12;ALSO of traumatic brain injury in children 14 "Hypoxia in a box" may reveal hidden concussion damage 18 Diabetes Clark, MSN'11, builds hope and health in Uganda Decade of the BRAIN #12;From 1990 through 2000, the U

  17. acquired brain injuries: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    acquired brain injuries First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Students requesting...

  18. acquired brain injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    acquired brain injury First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Students requesting...

  19. ankle injuries: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and produce adequate range ofmotion in the ankle joints, such as stroke or traumatic brain injury, frequently lose gait and balance function due in part to loss of ankle...

  20. artery injury model: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Prognostic Models in Traumatic Brain Injury. Open Access Theses and Dissertations Summary: ??Background: Prognostic models...

  1. Computational modeling of primary blast effects on the human brain

    E-Print Network [OSTI]

    Nyein, Michelle K. (Michelle Kyaw)

    2013-01-01T23:59:59.000Z

    Since the beginning of the military conflicts in Iraq and Afghanistan, there have been over 250,000 diagnoses of traumatic brain injury (TBI) in the U.S. military, with the majority of incidents caused by improvised explosive ...

  2. Neuropathology Following Repeated Traumatic Brain Injury and the Influence of Inflammatory Status on Injury Outcome

    E-Print Network [OSTI]

    Donovan, Virginia

    2014-01-01T23:59:59.000Z

    controlled cortical impact (mCCI) was used to induce mTBI asBregma (Figure 2.1B), where a mCCI (4mm diameter tip, 0.5mma second craniectomy and mCCI on the opposite (left)

  3. Classification of brain compartments and head injury lesions by neural networks applied to magnetic resonance images

    E-Print Network [OSTI]

    Kischell, Eric Robert

    1993-01-01T23:59:59.000Z

    ' (Member) A. D. Patton ( ead of epartment) August 1993 Major Subject: Electrical Engineering ABSTRACT Classification of Brain Compartments and Head Injury Lesions by Neural Networks Applied to Magnetic Resonance Images. (August 1993) Eric Robert... Kischell, B. S. , Northeastern University Chair of Advisory Committee: Dr. Nasser Kehtarnavaz An automatic neural network-based approach was ap- plied to segment brain compartments and closed-head-injury lesions in magnetic resonance (MR) images Two...

  4. Devastating Brain Injuries: Assessment and Management, Part I: Overview of Brain Death

    E-Print Network [OSTI]

    Dixon, Tara D; Malinoski, Darren

    2009-01-01T23:59:59.000Z

    349:667-674. 11. Capron AM. Brain death – well settled yetWijdicks EFM. The diagnosis of brain death. NEJM. 2001; 344:AA. Organ preservation in a brain dead patient: information

  5. Preventing Concussion A concussion is a brain injury. Concussions are caused by a bump,

    E-Print Network [OSTI]

    Devoto, Stephen H.

    . But sometimes concussion can lead to long- lasting problems. The best way to protect yourself and your family to reduce the chances that you or your family members will have a concussion or more serious brain injury: Wear a seat belt every time you drive or ride in a motor vehicle. Buckle your child in the car using

  6. Computational Modeling and Optimization of a Novel Shock Tube to Study Blast Induced Traumatic Brain Injury

    E-Print Network [OSTI]

    Anumolu, Pratima

    2014-08-06T23:59:59.000Z

    CCM+ (CD-adapco, NY, USA). Assumptions used to model the flow were unsteady, inviscid, compressible, axisymmetric flow with time-step of 1e-5s. Multiple regression was run on these parameters to establish empirical relationship with pressure profile...

  7. Baroreflex Sensitivity during Positional Changes in Patients with Traumatic Brain Injury

    E-Print Network [OSTI]

    McNair, Norma Dianne

    2012-01-01T23:59:59.000Z

    UCLA School of Nursing 700 Tiverton Avenue Los Angeles, CAUCLA School of Nursing 700 Tiverton Avenue Los Angeles, CAUCLA School of Nursing, 700 Tiverton Avenue, Los Angeles, CA

  8. Matrix Metalloproteinase Expression in Contusional Traumatic Brain Injury: A Paired Microdialysis Study

    E-Print Network [OSTI]

    Guilfoyle, Matthew R.; Carpenter, Keri L. H.; Helmy, Adel; Pickard, John D.; Menon, David K.; Hutchinson, Peter J. A.

    2015-05-14T23:59:59.000Z

    .30 Dox- ycycline, at subantimicrobial doses, has been shown to be of benefit in periodontitis, likely through its effect on MMP-9 activity.31 On the same basis, doxycycline has also been suggested as a treatment to stabilize growth of abdominal aortic...

  9. G. Christina Caballero 1 Ketamine Sedation in Traumatic Brain Injury: Friend or Foe?

    E-Print Network [OSTI]

    Pillow, Jonathan

    prophylaxis for 7 days Phenytoin 15-20 mg/kg load followed by 4-5 mg/kg/day Volume Status CPP and MAP

  10. Material Modeling and Development of a Realistic Dummy Testing Blast Induced Traumatic Brain Injury

    E-Print Network [OSTI]

    Farritor, Shane

    properties: ­ Step response analysis (low-frequency screening) ­ DMA analysis under compression and shear) #12;ARAMIS video system capturing the experiment The step response test set up with gel silicone sample Step Response Experiment · Step load applied to sample by burning string suspending weight #12

  11. Adherence to Head Computed Tomography Guidelines in the Setting of Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    Jones, Landon A; Morley, Eric J; Grant, William D; Wojcik, Susan M; Paolo, William F

    2014-01-01T23:59:59.000Z

    Adherence to Head Computed Tomography Guidelines for Mildal Adherence to Head Computed Tomography Guidelines system,non-contrast head computed tomography (CT) in patients with

  12. Comparison of frequency and time domain methods of assessment of cerebral autoregulation in traumatic brain injury

    E-Print Network [OSTI]

    Liu, Xiuyun; Czosnyka, Marek; Donnelly, Joseph; Budohoski, Karol P.; Varsos, Georgios V.; Nasr, Nathalie; Brady, Ken M.; Reinhard, Matthias; Hutchinson, Peter J.; Smielewski, Peter

    2014-11-19T23:59:59.000Z

    of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures. J Neurol Neurosurg Psychiatry 1965; 28: 449–452. 37. Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D... usually as frequencies properties of such a filter can be expressed by three parameters (frequency dependent): TF phase, gain and coherence. The TF gain reflects how much...

  13. Baroreflex Sensitivity during Positional Changes in Patients with Traumatic Brain Injury

    E-Print Network [OSTI]

    McNair, Norma Dianne

    2012-01-01T23:59:59.000Z

    2004). A n introduction to PET-CT imaging. RadioGraphics,D . R. (2006). PET and PET/CT imaging: What clinicians needPET), magnetic resonance imaging (MRI) and computerized tomography (CT)

  14. Reduction in radiation-induced brain injury by use of pentobarbital or lidocaine protection

    SciTech Connect (OSTI)

    Oldfield, E.H.; Friedman, R.; Kinsella, T.; Moquin, R.; Olson, J.J.; Orr, K.; DeLuca, A.M. (National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (USA))

    1990-05-01T23:59:59.000Z

    To determine if barbiturates would protect brain at high doses of radiation, survival rates in rats that received whole-brain x-irradiation during pentobarbital- or lidocaine-induced anesthesia were compared with those of control animals that received no medication and of animals anesthetized with ketamine. The animals were shielded so that respiratory and digestive tissues would not be damaged by the radiation. Survival rates in rats that received whole-brain irradiation as a single 7500-rad dose under pentobarbital- or lidocaine-induced anesthesia was increased from between from 0% and 20% to between 45% and 69% over the 40 days of observation compared with the other two groups (p less than 0.007). Ketamine anesthesia provided no protection. There were no notable differential effects upon non-neural tissues, suggesting that pentobarbital afforded protection through modulation of ambient neural activity during radiation exposure. Neural suppression during high-dose cranial irradiation protects brain from acute and early delayed radiation injury. Further development and application of this knowledge may reduce the incidence of radiation toxicity of the central nervous system (CNS) and may permit the safe use of otherwise unsafe doses of radiation in patients with CNS neoplasms.

  15. The study of the neurophysiology of high strain rate nerve injury

    E-Print Network [OSTI]

    Yang, In Hong

    2004-09-30T23:59:59.000Z

    Theresa A. Good (Co-Chair of Committee) (Co-Chair of Committee) __________________________ _________________________ William A. Hyman... Committee: Dr. Hsin-I Wu Dr. Theresa A. Good The study of the mechanism of traumatic brain injury (TBI) processes at the cellular level is vital to obtain characterization of nerve...

  16. Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms in OEF/OIF Veterans : : A Combined Diffusion Tensor Imaging and Cortical Thickness Study

    E-Print Network [OSTI]

    Sorg, Scott Francis

    2013-01-01T23:59:59.000Z

    them from the effects of the blast wave. For instance, in athe neurotraumatic effects of the primary blast wave isextent that blast waves do have a deleterious effect on the

  17. Routine Repeat Head CT may not be Indicated in Patients on Anticoagulant/Antiplatelet Therapy Following Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    McCammack, Kevin C.; Sadler, Charlotte; Guo, Yueyang; Ramaswamy, Raja S; Farid, Nikdokht

    2015-01-01T23:59:59.000Z

    therapy is frequently employed to treat or prevent vascularare separate units which both treat this patient population,

  18. Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus–CSF nexus

    E-Print Network [OSTI]

    Johanson, Conrad; Stopa, Edward; Baird, Andrew; Sharma, Hari

    2011-01-01T23:59:59.000Z

    Intraventricularly infused S100B stimulates neurogenesis andpeptide boosting Bovine S100B infused i.c.v. (osmotic pump)post-TBI rFGF2 (human) infused i.c.v. (osmotic pump) for 1

  19. Transcranial Low-Level Laser Therapy Improves Neurological Performance in Traumatic Brain Injury in Mice: Effect of Treatment Repetition Regimen

    E-Print Network [OSTI]

    Hamblin, Michael R.

    Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest ...

  20. Routine Repeat Head CT may not be Indicated in Patients on Anticoagulant/Antiplatelet Therapy Following Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    McCammack, Kevin C.; Sadler, Charlotte; Guo, Yueyang; Ramaswamy, Raja S; Farid, Nikdokht

    2015-01-01T23:59:59.000Z

    needed when the computed tomography scan is normal. Acadof noncontrast cranial computed tomography for the emergencyMcCammack et al. Head Computed Tomography anticoagulant and

  1. Routine Repeat Head CT may not be Indicated in Patients on Anticoagulant/Antiplatelet Therapy Following Mild Traumatic Brain Injury

    E-Print Network [OSTI]

    McCammack, Kevin C.; Sadler, Charlotte; Guo, Yueyang; Ramaswamy, Raja S; Farid, Nikdokht

    2015-01-01T23:59:59.000Z

    needed when the computed tomography scan is normal. AcadMcCammack et al. Head Computed Tomography anticoagulant andof sequential computed tomography scanning in anticoagulated

  2. Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain

    SciTech Connect (OSTI)

    Lin, Anya M.Y. [Department of Physiology, National Yang-Ming University, Taipei, Taiwan (China); Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan (China); Chao, P.L.; Fang, S.F.; Chi, C.W. [Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan (China); Yang, C.H. [Department of Oncology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan (China)], E-mail: chihyang@ntu.edu.tw

    2007-10-15T23:59:59.000Z

    The mechanism underlying sodium arsenite (arsenite)-induced neurotoxicity was investigated in rat brain. Arsenite was locally infused in the substantia nigra (SN) of anesthetized rat. Seven days after infusion, lipid peroxidation in the infused SN was elevated and dopamine level in the ipsilateral striatum was reduced in a concentration-dependent manner (0.3-5 nmol). Furthermore, local infusion of arsenite (5 nmol) decreased GSH content and increased expression of heat shock protein 70 and heme oxygenase-1 in the infused SN. Aggregation of {alpha}-synuclein, a putative pathological protein involved in several CNS neurodegenerative diseases, was elevated in the arsenite-infused SN. From the breakdown pattern of {alpha}-spectrin, both necrosis and apoptosis were involved in the arsenite-induced neurotoxicity. Pyknotic nuclei, cellular shrinkage and cytoplasmic disintegration, indicating necrosis, and TUNEL-positive cells and DNA ladder, indicating apoptosis was observed in the arsenite-infused SN. Arsenite-induced apoptosis was mediated via two different organelle pathways, mitochondria and endoplasmic reticulum (ER). For mitochondrial activation, cytosolic cytochrome c and caspase-3 levels were elevated in the arsenite-infused SN. In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels. Moreover, arsenite reduced procaspase 12 levels, an ER-specific enzyme in the infused SN. Taken together, our study suggests that arsenite is capable of inducing oxidative injury in CNS. In addition to mitochondria, ER stress was involved in the arsenite-induced apoptosis. Arsenite-induced neurotoxicity clinically implies a pathophysiological role of arsenite in CNS neurodegeneration.

  3. Social Work Delivered Intervention for Persons with Mild Traumatic Brain Injury: Implementation and Evaluation in an Urban, Public, Trauma Center Emergency Department

    E-Print Network [OSTI]

    Moore, Megan

    2012-01-01T23:59:59.000Z

    the typical month) G6 G7 G8 G9 G10 Who usually looked1 If yes, tell me about it. G8 Did you see the flyer for the= 4 Not applicable = 5 G6 G7 G8 G9 Who usually looked after

  4. aircrew integrated helmet: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Injury CERN Preprints Summary: Impact induced traumatic brain injury (ITBI) describes brain injury from head impact not necessarily accompanied by skull fracture. For...

  5. In vitro models for injurious compression of bovine and human articular cartilage

    E-Print Network [OSTI]

    Patwari, Parth, 1972-

    2003-01-01T23:59:59.000Z

    Patients who have sustained a traumatic joint injury, such as a ligament rupture or cartilage fracture, are known to have an increased risk for the development of osteoarthritis (OA) in that joint. This has motivated the ...

  6. Cartilage response to in vitro models of injury in combination with growth factor and antioxidant treatments

    E-Print Network [OSTI]

    Wheeler, Cameron, 1978-

    2008-01-01T23:59:59.000Z

    Approximately one in five Americans is affected by arthritis, making it one of the most prevalent diseases and the leading cause of disability in the United States. Post-traumatic arthritis occurs after joint injury (e.g., ...

  7. arm injuries: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Page Topic Index 1 UNDERSTANDING AND TREATING ARM MOVEMENT IMPAIRMENT AFTER CHRONIC BRAIN INJURY Biology and Medicine Websites Summary: Irvine, CA 92697 2: Sensory Motor...

  8. adenomyosis tissue injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Page Last Page Topic Index 1 Statistical prediction of tissue fate in acute ischemic brain injury Biology and Medicine Websites Summary: ) and apparent diffusion coefficient...

  9. acceleration head injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 2 Head injury...

  10. Helmets Designed by Supercomputers Help Warfighters at Home

    Broader source: Energy.gov [DOE]

    These supercomputing applications are helping protect warfighters from the blast waves produced by explosions that cause traumatic brain injury (TBI).

  11. BIOSIGNAL 2004, extended abstract Complex Analysis of Intracranial Hypertension in Traumatic

    E-Print Network [OSTI]

    BIOSIGNAL 2004, extended abstract Complex Analysis of Intracranial Hypertension in Traumatic Brain from a stable state of normal ICP (hypertension (ICH; ICP > 25 mm of intracranial hypertension: (1) the difference between the minimum value in the ICH region and the maximum value

  12. Embolization Therapy for Traumatic Splenic Lacerations

    SciTech Connect (OSTI)

    Dasgupta, Niloy; Matsumoto, Alan H., E-mail: ahm4d@virginia.edu; Arslan, Bulent; Turba, Ulku C.; Sabri, Saher; Angle, John F. [University of Virginia Health System, Division of Vascular and Interventional Radiology, Department of Radiology (United States)

    2012-08-15T23:59:59.000Z

    Purpose: This study was designed to evaluate the clinical success, complications, and transfusion requirements based on the location of and agents used for splenic artery embolization in patients with splenic trauma. Methods: A retrospective study was performed of patients with splenic trauma who underwent angiography and embolization from September 2000 to January 2010 at a level I trauma center. Electronic medical records were reviewed for demographics, imaging data, technical aspects of the procedure, and clinical outcomes. Results: Fifty patients were identified (34 men and 16 women), with an average age of 48 (range, 16-80) years. Extravasation was seen on initial angiography in 27 (54%) and was absent in 23 (46%). All 27 patients with extravasation were embolized, and 18 of 23 (78.2%) without extravasation were embolized empirically. Primary clinical success was similar (>75%) across all embolization locations, embolic agents, and grades of laceration treated. Of 45 patients treated, 9 patients (20%) were embolized in the main splenic artery, 34 (75.6%) in the splenic hilum, and 2 (4.4%) were embolized in both locations. Partial splenic infarctions developed in 47.3% treated in the splenic hilum compared with 12.5% treated in the main splenic artery. There were four (8.9%) mortalities: two occurred in patients with multiple critical injuries and two from nonbleeding etiologies. Conclusions: Embolization of traumatic splenic artery injuries is safe and effective, regardless of the location of treatment. Embolization in splenic hilar branches may have a higher incidence of infarction. The grade of laceration and agents used for embolotherapy did not impact the outcomes.

  13. On the Role of a Nonlinear Stress-Strain Relation in Brain Trauma

    E-Print Network [OSTI]

    Burtscher, Martin

    head using our generalization of the viscoelastic Kelvin-Voigt brain injury model that includes of the Brain Injury Criterion, which we developed to extend the translational Head Injury CriterionOn the Role of a Nonlinear Stress-Strain Relation in Brain Trauma Igor Szczyrba School

  14. N-3 FATTY ACIDS AND JUVENILE TRAUMATIC BRAIN INJURY: EFFECTS OF DIETARY N-3 FATTY ACID CONTENT, N-3 FATTY ACID STATUS, AND ORALLY DOSED FISH OIL ON SENSORIMOTOR AND BIOCHEMICAL OUTCOMES

    E-Print Network [OSTI]

    Russell, Kristin L.

    2013-08-31T23:59:59.000Z

    MMP Matrix metalloproteinase MUFA Monounsaturated fatty acid NF-?B Nuclear factor kappa B NMDA N-methyl-D-aspartic acid NPD1 Neuroprotectin D1 xii Abbreviation Full Name PBF Phosphate buffered formalin PBS Phosphate buffered...). Transcription of a pro-MMP-2 and pro-MMP-9 is regulated by nuclear factor kappa B (NF-?B) (Gottschall and Deb, 1996). The pro- forms are cleaved to active forms by each other and other MMPs when necessary (Nagase et al., 2006). MMPs are endogenously...

  15. Computational Modeling of Brain Dynamics during Repetitive Head Motions

    E-Print Network [OSTI]

    Burtscher, Martin

    Computational Modeling of Brain Dynamics during Repetitive Head Motions Igor Szczyrba School the HIC scale to arbitrary head motions. Our simulations of the brain dynamics in sagittal and horizontal injury modeling, resonance effects 1 Introduction A rapid head motion can result in a severe brain injury

  16. anticoagulant therapy case: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  17. anticoagulation therapy mr-tomographische: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  18. anticoagulation therapy elective: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  19. anticoagulant therapy re-ly: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  20. antiplatelet therapy i prevention: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  1. anticoagulant therapy inr: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    be Indicated in Patients on AnticoagulantAntiplatelet Therapy Following Mild Traumatic Brain Injury University of California eScholarship Repository Summary: head injury and an...

  2. Traumatic Inferior Gluteal Artery Pseudoaneurysm and Arteriovenous Fistula Managed with Emergency Transcatheter Embolization

    SciTech Connect (OSTI)

    Keeling, A. N. [Beaumont Hospital, Department of Academic Radiology (Ireland); Naughton, P. A.; Leahy, A. L. [Beaumont Hospital, Department of Vascular Surgery (Ireland); Lee, M. J., E-mail: mlee@rcsi.i [Beaumont Hospital, Department of Academic Radiology (Ireland)

    2008-07-15T23:59:59.000Z

    We present a case of blunt trauma to the buttock resulting in an inferior gluteal artery pseudoaneurysm and arteriovenous fistula. The characteristic diagnostic features on CT angiography and digital subtraction angiography (DSA), along with the emergency percutaneous management of this traumatic vascular injury, are described. A review of the literature demonstrates inferior gluteal artery pseudoaneurysm is a rare condition, while successful treatment with glue embolization is previously unreported.

  3. Endovascular Treatment of Blunt Traumatic Abdominal Aortic Occlusion With Kissing Stent Placement

    SciTech Connect (OSTI)

    Idoguchi, Koji, E-mail: idoguchi@ares.eonet.ne.jp; Yamaguchi, Masato; Okada, Takuya [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan); Nomura, Yoshikatsu [Kobe University Hospital, Department of Cardiovascular Surgery (Japan); Sugimura, Kazuro [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan); Okita, Yutaka [Kobe University Hospital, Department of Cardiovascular Surgery (Japan); Sugimoto, Koji [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan)

    2012-10-15T23:59:59.000Z

    Blunt traumatic abdominal aortic dissection is extremely rare and potentially deadly. We present the case of a 62-year-old man involved in a frontal car crash. After emergency undergoing laparotomy for bowel injuries, he was referred to our hospital due to acute ischemia of bilateral lower extremities on day 3 after the trauma. Computed tomography and aortography showed an aortobiiliac dissection with complete occlusion. This injury was successfully treated by endovascular treatment with 'kissing'-technique stent placement, which appears to be a safe, effective, and minimally invasive treatment.

  4. Covered Stent-Graft Treatment of Traumatic Internal Carotid Artery Pseudoaneurysms: A Review

    SciTech Connect (OSTI)

    Maras, Dimitrios; Lioupis, Christos [Red Cross Hospital of Athens, Department of Vascular Surgery (Greece)], E-mail: lioupisC@panafonet.gr; Magoufis, George; Tsamopoulos, Nikolaos [Henry Dynant Hospital, Department of Diagnostic and Therapeutic Neuroradiology (Greece); Moulakakis, Konstantinos; Andrikopoulos, Vasilios [The Red Cross Hospital of Athens, Department of Vascular Surgery (Greece)

    2006-12-15T23:59:59.000Z

    Objective. To review the literature concerning the management with placement of covered stent-grafts of traumatic pseudoaneurysms of the extracranial internal carotid artery (ICA) resulting from penetrating craniocervical injuries or skull base fractures. Method. We have reviewed, from the Medline database, all the published cases in the English literature since 1990 and we have added a new case. Results. We identified 20 patients with traumatic extracranial ICA pseudoaneurysms due to penetrating craniocervical injuries or skull base fractures who had been treated with covered stent-graft implantation. Many discrepancies have been ascertained regarding the anticoagulation therapy. In 3 patients the ICA was totally occluded in the follow-up period, giving an overall occlusion rate 15%. No serious complication was reported as a result of the endovascular procedure. Conclusion. Preliminary results suggest that placement of stent-grafts is a safe and effective method of treating ICA traumatic pseudoaneurysms resulting from penetrating craniocervical injuries or skull base fractures. The immediate results are satisfactory when the procedure takes place with appropriate anticoagulation therapy. The periprocedural morbidity and mortality and the early patency are also acceptable. A surveillance program with appropriate interventions to manage restenosis may improve the long-term patency.

  5. Brain Imaging Findings in Neuropathic Pain

    E-Print Network [OSTI]

    Apkarian, A. Vania

    Brain Imaging Findings in Neuropathic Pain Paul Y. Geha, MD and A. Vania Apkarian, PhD* Address (posther- petic neuralgia), then the spinal cord (postspinal cord injury pain), to the brain itself mechanisms; hence, they assume implicitly or explicitly that the rest of the brain passively responds

  6. , SEYMOUR AND MacGREGOR COGNlTlYb NEUROPSYCHOLOGY. IdyslexIa. Brain. 102. 4363.

    E-Print Network [OSTI]

    Mehler, Jacques

    .T. (1980) Word-form dyslexIa. Brain. 102. 4363. REFERENCENOTES On Reducing Language to Biology I. Holmes. J. M. (1973) Dyslexia: a lIeurolinguistic study 0/ traumatic and developmental disorders 0/ reading

  7. accident-related fatal injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    using intelligent data analysis of admission variables and time series physiological brain damage in a series of 151 fatal cases of severe head injury subjected to autopsy....

  8. Detection of Early Morning Daily Activities with Static Home and Wearable Wireless Nuri Firat Ince1, 2

    E-Print Network [OSTI]

    Minnesota, University of

    or a penetrating injury to the head. In general, the frontal part of the brain is damaged in TBI cases. The frontal monitoring system for assisting patients with cognitive impairments due to traumatic brain injury (TBI tasks respectively. Keywords: Traumatic Brain Injury, Cognitively Impaired, Wearable Sensors, Wireless

  9. Optical spectroscopy for the detection of ischemic tissue injury

    DOE Patents [OSTI]

    Demos, Stavros (Livermore, CA); Fitzgerald, Jason (Sacramento, CA); Troppmann, Christoph (Sacramento, CA); Michalopoulou, Andromachi (Athens, GR)

    2009-09-08T23:59:59.000Z

    An optical method and apparatus is utilized to quantify ischemic tissue and/or organ injury. Such a method and apparatus is non-invasive, non-traumatic, portable, and can make measurements in a matter of seconds. Moreover, such a method and apparatus can be realized through optical fiber probes, making it possible to take measurements of target organs deep within a patient's body. Such a technology provides a means of detecting and quantifying tissue injury in its early stages, before it is clinically apparent and before irreversible damage has occurred.

  10. acute subtentorial hematoma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    vessel rupture is the major diagnosis have become popular research topics. For traumatic brain injury (TBI), head computed tomography Tan, Chew Lim 8 Open Access Airway Compromise...

  11. atrial septal hematoma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    vessel rupture is the major diagnosis have become popular research topics. For traumatic brain injury (TBI), head computed tomography Tan, Chew Lim 14 Fast block flow tracking of...

  12. Detrimental Effects of Uncontrollable Stimulation on Recovery After Spinal Cord Injury

    E-Print Network [OSTI]

    Hudson, Kara

    2007-07-23T23:59:59.000Z

    using a spinal contusion surgery on rats to simulate spinal cord injury, and uncontrollable shock to act as pain signals from peripheral injury. Although it is known that the brain is necessary for this destructive effect to occur, it is not known...

  13. Neuroscience/Brain & Mind For the past 40 years, some of Western University's most internationally

    E-Print Network [OSTI]

    Denham, Graham

    Neuroscience/Brain & Mind For the past 40 years, some of Western University's most internationally of the brain that bring together some of the most accomplished minds at the forefront of neuroscience research to degenerative and neuromuscular disorders, spinal injury, stroke, aneurysms and brain tumours · Uses highly

  14. Development of a helmet liner for protection against blast induced trauma

    E-Print Network [OSTI]

    Christou, George Alexander

    2010-01-01T23:59:59.000Z

    Traumatic brain injuries caused by shock waves have attracted increased medical and scientific attention due to the large percentage of combat troops that have sustained such injuries in recent conflict theatres. To this ...

  15. Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering

    E-Print Network [OSTI]

    Bolliet, Catherine

    2007-01-01T23:59:59.000Z

    Recent advances in tissue engineering, combining an extracellular matrix (ECM)-like vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis ...

  16. Injectable chemokine-releasing gelatin matrices for enhancing endogenous regenerative responses in the injured rat brain

    E-Print Network [OSTI]

    Lim, Teck Chuan

    2014-01-01T23:59:59.000Z

    Brain injuries acquired from hemorrhage, ischemic strokes and trauma affect millions worldwide each year and often cause irreversible loss of neural tissue that disrupts vital neurological functions. Cell transplantation ...

  17. Brain-Computer Interfaces

    E-Print Network [OSTI]

    Aggarwal, Khushbu

    2009-01-01T23:59:59.000Z

    I \\ November 16, 2008). CNN. ’Brain’ in a dish ?ies ?ightREFERENCES Adams, Ray. Brain Computer Interfaces: Psychologyaccessed Biever, Celeste. Brain cells in a dish ?y ?ghter

  18. MicroRNA Dysregulation Following Spinal Cord Contusion: Implications for Neural Plasticity and Neuropathic Pain

    E-Print Network [OSTI]

    Strickland, Eric

    2013-05-30T23:59:59.000Z

    Injury The central nervous system (CNS) is highly vulnerable to injury, which can result in substantial cognitive and behavioral impairment. Acute insult to the brain, such as traumatic brain injury (TBI) and ischemic stroke, is one of the most common... the vasculature through strict maintenance and modulation of the blood-brain barrier and blood-spinal cord barrier, but acute CNS injury disrupts proper blood-brain and blood-spinal cord barrier regulation triggering an inflammatory response (Perry, 1998...

  19. neuroscience / brain & mind neuroscience / brain & mind

    E-Print Network [OSTI]

    Denham, Graham

    neuroscience / brain & mind #12;neuroscience / brain & mind Investment Construction of new Centre for Brain & Mind $3.6million External funding for researchers $60million Provincial investment in a 3T and one of three 7T MRI in the world $12million #12;neuroscience / brain & mind Recruitment and Building

  20. acute brain stem: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    brain stem First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Acute Injury Phase Clinical Trials in Acute...

  1. acute brain trauma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    acute brain trauma First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Acute Injury Phase Clinical Trials...

  2. Vortices in Brain waves

    E-Print Network [OSTI]

    Freeman, Walter J III; Vitiello, Giuseppe

    2010-01-01T23:59:59.000Z

    Burke and M. D. Holmes, Human Brain Mapping 19(4), 248 7. W.20. W. J. Freeman, How Brains Make Up Their Minds (Columbiaand K. Yasue, Quantum Brain Dynamics and Consciousness (John

  3. Singing the Brain Electric

    E-Print Network [OSTI]

    Chua, Grace (Grace W. J.)

    2008-01-01T23:59:59.000Z

    Singing the Brain Electric Brain pacemakers, scientists have found, can treat depression by correcting neural circuitry gone haywire. This thesis examines how such technology - a technique known as deep-brain stimulation, ...

  4. Assessing Visuospatial Neglect in Children with Brain Injury

    E-Print Network [OSTI]

    Wahlberg, Andrea Christine

    2014-05-28T23:59:59.000Z

    . While some individual adult tests have been modified for use with children, no standardized battery to assess VSN in young children currently exists. The present study investigated the reliability and validity of a five-task neuropsychological testing...

  5. Hydrogen is Neuroprotective against Surgically Induced Brain Injury

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    as: Eckermann et al. : Hydrogen is neuroprotective againstSBI, and SBI treated with hydrogen rats. We found, however,Katayama Y, Asoh S, Ohta S: Hydrogen acts as a therapeutic

  6. Gene expression abnormalities in the autistic brain

    E-Print Network [OSTI]

    Chow, Maggie Lok Mun

    2011-01-01T23:59:59.000Z

    13 Early Brain Overgrowth13 Discontinuous brainpostmortem brain ______________________________________ 33

  7. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

  8. Study of an advanced helmet liner concept to reduce TBI : experiments & simulation using sandwich structures

    E-Print Network [OSTI]

    Goel, Rahul, S.M. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    A large percentage of combat troops suffered Traumatic Brain Injuries (TBI) due to Improvised Explosive Devices (IEDs) in recent wars in the Middle East. The majority of TBIs were caused by exposure to blast waves. Use of ...

  9. Zrich, den 31. Mai 2001 Bildungsdirektion

    E-Print Network [OSTI]

    Zürich, Universität

    in Zürich ,,The significance of Fas/Apo-1 in the pathophyisology of traumatic brain injury" Marti Lukas M-Rekonstruktion des Dickdarmes aus einem digitalen, anatomischen Datensatz" Peternac Daniel, von Neuhausen am

  10. Cell biomechanics of the central nervous system

    E-Print Network [OSTI]

    Bernick, Kristin Briana

    2011-01-01T23:59:59.000Z

    Traumatic brain injury (TBI) is a significant cause of death and morbidity in both the civilian and military populations. The major causes of TBI, such as motor vehicle accidents, falls, sports concussions, and ballistic ...

  11. artificial peptide tbi: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    QU, M.D., DUNYUE LU, M.D., PH.D., ANTON. Atorvastatin administered after traumatic brain injury (TBI) induced by controlled cortical impact promotes trauma or in the...

  12. Treatment of a Traumatic Celiac Trunk Detachment by Bridging with a Stent Graft

    SciTech Connect (OSTI)

    Choi, In Young; Chung, Hwan Hoon, E-mail: chungmic@korea.ac.kr; Lee, Seung Hwa, E-mail: yaaong@hitel.net; Cho, Sung Bum, E-mail: anglercho@gmail.com; Kim, Yun Hwan, E-mail: yhkku@korea.ac.kr; Seo, Bo Kyoung, E-mail: seoboky@korea.ac.kr; Seo, Hyung-Seok, E-mail: casebase@hanmail.net [Korea University Ansan Hospital, Korea University College of Medicine, Department of Radiology (Korea, Republic of)

    2012-04-15T23:59:59.000Z

    Traumatic detachment of the celiac trunk from the abdominal aorta is a rare clinical situation, and proper treatment options have not been established. We report a patient with traumatic separation of the celiac trunk treated by bridging with a covered stent between the celiac trunk and abdominal aorta.

  13. Mechanisms of brain ventricle development

    E-Print Network [OSTI]

    Lowery, Laura Anne

    2008-01-01T23:59:59.000Z

    The brain ventricles are a conserved system of fluid-filled cavities within the brain that form during the earliest stages of brain development. Abnormal brain ventricle development has been correlated with neurodevelopmental ...

  14. Optogenetic Brain Interfaces

    E-Print Network [OSTI]

    Pashaie, Ramin

    The brain is a large network of interconnected neurons where each cell functions as a nonlinear processing element. Unraveling the mysteries of information processing in the complex networks of the brain requires versatile ...

  15. I am John's Brain 

    E-Print Network [OSTI]

    Clark, Andy

    1995-01-01T23:59:59.000Z

    The brain and its "agent" debate the provenance of thoughts in the charming language of an old Readers Digest article.

  16. NAVIGATING THE BRAIN'S MYSTERIES

    E-Print Network [OSTI]

    C C C A A A A G A G G D D D D D F D F F F H H H E E E E FHE E B B B C E B NAVIGATING THE BRAIN of the brain-- one that shows its complex trafficking across trillions of neuronal connections. Addressing: outlining "the next great American project," the BRAIN (Brain Research through Advancing Innovative

  17. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

  18. A First-Order Mechanical Device to Model Traumatized Craniovascular

    E-Print Network [OSTI]

    . This secondary response, in turn, causes cell death and potentially permanent impairment, all of which is further exacerbated by au- toregulatory dysfunction. Recovery is unpredictable and most cognitive improvement comes, but the endpoint for partial or full recovery is unknown. Modeling of injury causation and the resulting

  19. The Brain Basis of Emotions 1 BRAIN BASIS OF EMOTION

    E-Print Network [OSTI]

    Barrett, Lisa Feldman

    The Brain Basis of Emotions 1 BRAIN BASIS OF EMOTION The brain basis of emotion: A meta, Building 149 Charlestown, MA 02129 lindqukr@nmr.mgh.harvard.edu #12;The Brain Basis of Emotions 2 Abstract Researchers have wondered how the brain creates emotions since the early days of psychological science

  20. Original Contrbution Induction of oxidative and nitrosative damage leads to cerebrovascular

    E-Print Network [OSTI]

    Farritor, Shane

    Original Contrbution Induction of oxidative and nitrosative damage leads to cerebrovascular 2013 Available online 4 March 2013 Keywords: Mild traumatic brain injury Blood­brain barrier Oxidative the hypothesis that oxidative damage of the cerebral vascular barrier interface (the blood­brain barrier, BBB

  1. RICE UNIVERSITY ACCIDENT/INJURY REPORT

    E-Print Network [OSTI]

    Natelson, Douglas

    RICE UNIVERSITY ACCIDENT/INJURY REPORT Please Print Section A: Details of incident Injury Work Exposure to radiation Mental stress factors Noise Insect/animal bite Vehicle accident Slip

  2. Portable MRI

    SciTech Connect (OSTI)

    Espy, Michelle A. [Los Alamos National Laboratory

    2012-06-29T23:59:59.000Z

    This project proposes to: (1) provide the power of MRI to situations where it presently isn't available; (2) perform the engineering required to move from lab to a functional prototype; and (3) leverage significant existing infrastructure and capability in ultra-low field MRI. The reasons for doing this: (1) MRI is the most powerful tool for imaging soft-tissue (e.g. brain); (2) Billions don't have access due to cost or safety issues; (3) metal will heat/move in high magnetic fields; (4) Millions of cases of traumatic brain injury in US alone; (5) even more of non-traumatic brain injury; (6) (e.g. stroke, infection, chemical exposure); (7) Need for early diagnostic; (8) 'Signature' wound of recent conflicts; (9) 22% of injuries; (10) Implications for post-traumatic stress disorder; and (11) chronic traumatic encephalopathy.

  3. Spatiotemporal brain imaging and modeling

    E-Print Network [OSTI]

    Lin, Fa-Hsuan, 1972-

    2004-01-01T23:59:59.000Z

    This thesis integrates hardware development, data analysis, and mathematical modeling to facilitate our understanding of brain cognition. Exploration of these brain mechanisms requires both structural and functional knowledge ...

  4. The Brain, the Broken Brain & the Neural Biology of Language

    E-Print Network [OSTI]

    Collar, Juan I.

    The Brain, the Broken Brain & the Neural Biology of Language Presenter: Steven Small Time & Date.maproom.com )1949 N. Hoyne Café Email list https://cfcpwork.uchicago.edu/mailman/listinfo/cafe #12;The Brain, the Broken Brain & the Neural Biology of Language Presenter: Steven Small Time & Date: 7-9 PM Monday

  5. CHAPTER 4: THE DEEPWATER HORIZON OIL SPILL NATURAL RESOURCE INJURY ASSESSMENT.................1 4.1 The Injury Assessment Process: Assessing Injuries in a Complex, Interconnected Ecosystem ....1

    E-Print Network [OSTI]

    .1 The Injury Assessment Process: Assessing Injuries in a Complex, Interconnected Ecosystem ....1 4.2 Injuries the public with an overview of the potential impacts to resources in the Gulf of Mexico ecosystem caused

  6. Irradiation Alters MMP-2/TIMP-2 System and Collagen Type IV Degradation in Brain

    SciTech Connect (OSTI)

    Lee, Won Hee [School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (United States); Warrington, Junie P.; Sonntag, William E. [Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (United States); Lee, Yong Woo, E-mail: ywlee@vt.edu [School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (United States); Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia (United States)

    2012-04-01T23:59:59.000Z

    Purpose: Blood-brain barrier (BBB) disruption is one of the major consequences of radiation-induced normal tissue injury in the central nervous system. We examined the effects of whole-brain irradiation on matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) and extracellular matrix (ECM) degradation in the brain. Methods and Materials: Animals received either whole-brain irradiation (a single dose of 10 Gy {gamma}-rays or a fractionated dose of 40 Gy {gamma}-rays, total) or sham-irradiation and were maintained for 4, 8, and 24 h following irradiation. mRNA expression levels of MMPs and TIMPs in the brain were analyzed by real-time reverse transcriptase-polymerase chain reaction (PCR). The functional activity of MMPs was measured by in situ zymography, and degradation of ECM was visualized by collagen type IV immunofluorescent staining. Results: A significant increase in mRNA expression levels of MMP-2, MMP-9, and TIMP-1 was observed in irradiated brains compared to that in sham-irradiated controls. In situ zymography revealed a strong gelatinolytic activity in the brain 24 h postirradiation, and the enhanced gelatinolytic activity mediated by irradiation was significantly attenuated in the presence of anti-MMP-2 antibody. A significant reduction in collagen type IV immunoreactivity was also detected in the brain at 24 h after irradiation. In contrast, the levels of collagen type IV were not significantly changed at 4 and 8 h after irradiation compared with the sham-irradiated controls. Conclusions: The present study demonstrates for the first time that radiation induces an imbalance between MMP-2 and TIMP-2 levels and suggests that degradation of collagen type IV, a major ECM component of BBB basement membrane, may have a role in the pathogenesis of brain injury.

  7. Children's Brain Development Benefits from Longer Gestation

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    Mapping of the Human Brain. NeuroImage, Sendai, Japan.2005). Regional deficits in brain volume in schizophrenia: areso- nance imaging of brain development in premature and

  8. Genomic mosaicism in the human brain

    E-Print Network [OSTI]

    Westra, Jurjen Willem

    2008-01-01T23:59:59.000Z

    Zlokovic BV (2008) The blood-brain barrier in health andmosaicism in the human brain ………………………………………. Chapter Threethe Alzheimer’s disease brain ………………………………. Chapter Five DNA

  9. MR imaging of the fetal brain

    E-Print Network [OSTI]

    Glenn, Orit A.

    2010-01-01T23:59:59.000Z

    development of the fetal brain by MRI. Semin Perinatol 33:determination in normal fetal brain: a prenatal MR imagingin intrauterine fetal brain development. In: Abstracts of

  10. Life Exposures to Traumatic Events and Chronic Strains Among Older Mexican-Origin Individuals

    E-Print Network [OSTI]

    Garcia, Marc

    2012-10-19T23:59:59.000Z

    affects the physical health outcomes of Latinos. This thesis examines the extent to which traumatic life events and chronic strains affect the physical health outcomes of foreign-born and native-born Mexican-origin individuals (age 45 an older) residing...

  11. aviation crash injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Aircraft Accident," Crash Injury Res., Phoenix, Arizona (October 18, 1961). 4. Bruggink, G. M. eta., "Injury Reduction Trends in Agricultural Aviation," A m-MnM 35,...

  12. Brain Energy Metabolism During Experimental Neonatal Seizures

    E-Print Network [OSTI]

    Wasterlain, Claude G.; Thompson, Kerry W.; Suchomelova, Lucie; Niquet, Jerome

    2010-01-01T23:59:59.000Z

    premature or term neonate, brain ATP concentrations measuredreversible energy loss in the hypoxic immature rat brain.Brain Res Dev Brain Res 73(1):99–105 20. King LJ, Lowry OH,

  13. Prior information for brain parcellation

    E-Print Network [OSTI]

    Pohl, Kilian Maria

    2005-01-01T23:59:59.000Z

    To better understand brain disease, many neuroscientists study anatomical differences between normal and diseased subjects. Frequently, they analyze medical images to locate brain structures influenced by disease. Many of ...

  14. Methods for assisting recovery of damaged brain and spinal cord using arrays of X-Ray microplanar beams

    DOE Patents [OSTI]

    Dilmanian, F. Avraham (Yaphank, NY); McDonald, III, John W. (Baltimore, MD)

    2007-12-04T23:59:59.000Z

    A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.

  15. Methods for assisting recovery of damaged brain and spinal cord using arrays of X-ray microplanar beams

    DOE Patents [OSTI]

    Dilmanian, F. Avraham; McDonald, III, John W.

    2007-01-02T23:59:59.000Z

    A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.

  16. How Minds Work Brains, Ontologies &

    E-Print Network [OSTI]

    Memphis, University of

    or software agent is a virtual machine implemented on another virtual machine · The minds of humans or animals are virtual machines implemented on brains #12;Brains, Ontologies & Virtual Machines 13 Virtual1 How Minds Work Brains, Ontologies & Virtual Machines Stan Franklin Computer Science Division

  17. Long-term Neurological Outcomes in Adults with Traumatic Intracranial Hemorrhage Admitted to ICU versus Floor

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    mechanism of injury, initial ED GCS score, initial systolic blood pressure (SBP), heart rate, and respiratory rate, revised trauma score (physiological scoring system

  18. Life Satisfaction Over the First Five Years Following Burn Injury

    E-Print Network [OSTI]

    Hoskins, Jessica Lynne

    2012-10-19T23:59:59.000Z

    Page 1 Frequency Distribution of Demographic Characteristics ........................... 33 2 Number of Observations for Measures ...................................................... 34 3 Means, SDs, and Model Abbreviations for Self... 1 (minor) to 6 (unsurvivable). In the current sample, the majority of participants (43%) had injury ratings of moderate (n = 112, injury rating of 2), followed by injury ratings of serious (25%; n = 65; injury rating of 3). The remaining...

  19. Interference Effects in the Brain

    E-Print Network [OSTI]

    Jerzy Szwed

    2008-03-14T23:59:59.000Z

    Interference effects are the most spectacular manifestation of the wave nature of phenomena. This note proposes a systematic search for such effects in the brain.

  20. Metastasis Infiltration: An Investigation of the Postoperative Brain-Tumor Interface

    SciTech Connect (OSTI)

    Raore, Bethwel [Department of Neurological Surgery, Emory University, Atlanta, GA (United States); Schniederjan, Matthew [Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA (United States); Prabhu, Roshan [Department of Radiation Oncology, Emory University, Atlanta, GA (United States); Brat, Daniel J. [Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA (United States); Shu, Hui-Kuo [Department of Radiation Oncology, Emory University, Atlanta, GA (United States); Olson, Jeffrey J., E-mail: jolson@emory.edu [Department of Neurological Surgery, Emory University, Atlanta, GA (United States)

    2011-11-15T23:59:59.000Z

    Purpose: This study aims to evaluate brain infiltration of metastatic tumor cells past the main tumor resection margin to assess the biological basis for the use of stereotactic radiosurgery treatment of the tumor resection cavity and visualized resection edge or clinical target volume. Methods and Materials: Resection margin tissue was obtained after gross total resection of a small group of metastatic lesions from a variety of primary sources. The tissue at the border of the tumor and brain tissue was carefully oriented and processed to evaluate the presence of tumor cells within brain tissue and their distance from the resection margin. Results: Microscopic assessment of the radially oriented tissue samples showed no tumor cells infiltrating the surrounding brain tissue. Among the positive findings were reactive astrocytosis observed on the brain tissue immediately adjacent to the tumor resection bed margin. Conclusions: The lack of evidence of metastatic tumor cell infiltration into surrounding brain suggests the need to target only a narrow depth of the resection cavity margin to minimize normal tissue injury and prevent treatment size-dependent stereotactic radiosurgery complications.

  1. Brain MRI Classification using the Expectation Maximization

    E-Print Network [OSTI]

    Chen, Tsuhan

    Brain MRI Classification using the Expectation Maximization made a brain magnetic resonance image (MRI) classification algorithm that uses a twostage applied to a set of normal brain MR images for further testing. We accomplished a working

  2. Vascular pathology in the aged human brain

    E-Print Network [OSTI]

    Grinberg, Lea Tenenholz; Thal, Dietmar Rudolf

    2010-01-01T23:59:59.000Z

    vascular pathology, and the AD brain. Neurology 65: 259–265brospinal ?uid from the rat brain. Acta Neuropathol (Berl)and Alzheimer’s disease in the brains of elderly individuals

  3. Injury experience in stone mining, 1992

    SciTech Connect (OSTI)

    Not Available

    1994-05-01T23:59:59.000Z

    This Mine Safety and Health Administration (MSHA) informational report reviews in detail the occupational injury and illness experience of stone mining in the United States for 1992. Data reported by operators of mining establishments concerning work injuries are summarized by work location, accident classification, part of body injured, nature of injury, occupation, and principal type of mineral. Related information on employment, worktime, and operating activity also is presented. Data reported by independent contractors performing certain work at mining locations are depicted separately in this report. For ease of comparison with other metal and nonmetallic mineral mining industries and with coal mining, summary reference tabulations are included at the end of both the operator and the contractor sections of this report.

  4. Stent-Assisted Coil Embolization of a Traumatic Wide-Necked Renal Segmental Artery Pseudoaneurysm

    SciTech Connect (OSTI)

    Schlunz-Hendann, Martin; Wetter, Axel, E-mail: axel.wetter@klinikum-duisburg.de [Duisburg Clinical Center, Clinic of Radiology and Neuroradiology (Germany); Landwehr, Peter [Hospital Henriettenstiftung, Clinic of Diagnostic and Interventional Radiology (Germany); Brassel, Friedhelm [Duisburg Clinical Center, Clinic of Radiology and Neuroradiology (Germany)

    2011-10-15T23:59:59.000Z

    We present the case of an Afghan woman with a renal segmental artery false aneurysm of the right kidney due to a shell splinter injury. Stent-assisted coil embolization of the aneurysm is described in detail.

  5. Type B Accident Investigation Board Report on the Head Injury...

    Office of Environmental Management (EM)

    on the Head Injury to a Miner at the Waste Isolation Pilot Plant, Carlsbad, New Mexico - August 25, 2004 Type B Accident Investigation Board Report on the Head Injury to a Miner at...

  6. Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, treats myocardial reperfusion injury

    E-Print Network [OSTI]

    Perry, Cynthia Nicole

    2011-01-01T23:59:59.000Z

    Transfer Enzyme, Ndi1, Treats Myocardial Reperfusion InjuryTransfer Enzyme, Ndi1, Treats Myocardial Reperfusion Injury

  7. Rapid brain scanning radiopharmaceutical

    DOE Patents [OSTI]

    Sargent, T.W. III; Shulgin, A.T.; Mathis, C.A.

    1987-03-03T23:59:59.000Z

    A method for detecting the blood flow in animals, particularly in the brain, is provided wherein a detectable amount of a novel radioactive compound of the formula 1 is administered to one animal: as given in figure in patent wherein R[sub 1] and R[sub 2] are independently alkyl of 1 to 6 carbon atoms or benzyl; R[sub 3] is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R[sub 4] is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R[sub 4] is not isopropyl and when R[sub 4] is methyl, R[sub 3] is not benzyl; and X is a radioactive halogen. 2 figs.

  8. Rapid brain scanning radiopharmaceutical

    DOE Patents [OSTI]

    Sargent, III, Thornton W. (Berkeley, CA); Shulgin, Alexander T. (Lafayette, CA); Mathis, Chester A. (Oakland, CA)

    1987-01-01T23:59:59.000Z

    A method for detecting the blood flow in animals, particularly in the brain, is provided wherein a detectable amount of a novel radioactive compound of the formula I is administered to one animal: ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R.sub.3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R.sub.4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R.sub.4 is not isopropyl and when R.sub.4 is methyl, R.sub.3 is not benzyl; and X is a radioactive halogen.

  9. To: Supervisors and Managers Subject: Computer-Related Ergonomic Injuries

    E-Print Network [OSTI]

    Knowles, David William

    To: Supervisors and Managers Subject: Computer-Related Ergonomic Injuries Date: March 14, 2007 The statistics we have collected at the Lab this year are disturbing to me in the area of ergonomic injuries from-blown injuries. Over the next seven days, all supervisors must meet with their employees, discuss good ergonomic

  10. Accident/Injury Reporting, Investigation, & Basic First Aid Plan

    E-Print Network [OSTI]

    Long, Nicholas

    Accident/Injury Reporting, Investigation, & Basic First Aid Plan Environmental Health, Safety of accidents/injuries at Stephen F. Austin State University (SFASU) and provides basic first aid practices. It is designed to help reduce injuries by reducing unsafe or hazardous conditions and discouraging accident

  11. A measure of experiences with violence and post-traumatic stress disorder

    E-Print Network [OSTI]

    Benson, Krista Nicole

    2013-02-22T23:59:59.000Z

    ABSTRACT Page ACKNOWLEDGMENTS 1V TABLE OF CONTENTS. . LIST OF TABLES INTRODUCTION V1 METHOD. DISCUSSION & CONCLUSIONS. . REFERENCES. 31 VITA LIST OF TABLES DEMOGlu PHICS Page 7 ALCOHOLIC BEVERAGES CONSUMED PER SETTING. 13 PREVALENCE OF SLt... how frequently they use alcohol, caffeine. and tobacco (from I to 9/"not at all" to "several times daily" ) and then hov' much they use in one setting. O~Ed~dt Pd p t p ddt p - ddq tt . If they had indicated 'yes' to experiencing a traumatic event...

  12. Lung injury in dimethyl sulfate poisoning

    SciTech Connect (OSTI)

    Ip, M.; Wong, K.L.; Wong, K.F.; So, S.Y.

    1989-02-01T23:59:59.000Z

    Two manual laborers were exposed to dimethyl sulfate during work and sustained mucosal injury to the eyes and respiratory tract. In one of them, noncardiogenic pulmonary edema occurred and improved with high-dose methylprednisolone. On follow-up for 10 months, this patient developed persistent productive cough with no evidence of bronchiectasis or bronchial hyperreactivity.

  13. Injury / Incident Report INSTRUCTIONS ON REVERSE

    E-Print Network [OSTI]

    Hitchcock, Adam P.

    OF INJURY NONE EMPLOYER PHYSICIAN EMERGENCY FAMILY PHYSICIAN OTHER PHYSICIAN / SPECIALIST TO YOUR. _________________________________________ Room #___________________ STATE EXACTLY - THE SEQUENCE OF EVENTS LEADING UP TO THE INCIDENT, WHERE TO USE PERSONAL PROTECTIVE DEVICES 8 NOT GUARDED OR IMPROPERLY GUARDED 9 INADEQUATE ILLUMINATION 10

  14. Injury experience in coal mining, 1991

    SciTech Connect (OSTI)

    Not Available

    1991-12-31T23:59:59.000Z

    This Mine Safety and Health Administration (MSHA) informational report reviews in detail the occupational injury and illness experience of coal mining in the United States for 1991. Data reported by operators of mining establishments concerning work injuries are summarized by work location, accident classification, part of body injured, nature of injury, occupation, and anthracite or bituminous coal. Related information on employment, worktime, and operating activity also is presented. Data reported by independent contractors performing certain work at mining locations are depicted separately in this report. For ease of comparison between coal mining and the metal and nonmetal mineral mining industries, summary reference tabulations are included at the end of both the operator and the contractor sections of this report. Data used in compiling this report were reported by operators of coal mines and preparation plants on a mandatory basis as required under the Federal Mine Safety and Health Act of 1977, Public Law 91-173,as amended by Public Law 95-164. Since January 1, 1978, operators of mines or preparation plants or both which are subject to the Act have been required under 30 CFR, Part 50, to submit reports of injuries, occupational illnesses, and related data.

  15. BU BRAIN Self Service GRADING PROCEDURES

    E-Print Network [OSTI]

    Suzuki, Masatsugu

    1 BU BRAIN Self Service GRADING PROCEDURES FOR FACULTY Updated May 2014/PD #12;2 Table of Contents BRAIN Self Service icon on left side of page: #12;4 Entering Grades: Once in BU BRAIN Self Service, go BRAIN Self Service; Registered ­ student registered through the department). Grade: Student's grade

  16. Whole-Brain Thinking in Systems Architecting

    E-Print Network [OSTI]

    Udwadia, Firdaus E.

    Whole-Brain Thinking in Systems Architecting Tony Di Carlo,1, * Behrokh Khoshnevis,2 and Firdaus, University of Southern California, Los Angeles, CA 90089 WHOLE-BRAIN THINKING IN SYSTEMS ARCHITECTING paper explores the role of whole-brain thinking in the context of systems architecting. Brain research

  17. 5 Minute Brain Teaser Old vs. New Thinking Regarding the Human Brain

    E-Print Network [OSTI]

    5 Minute Brain Teaser Old vs. New Thinking Regarding the Human Brain Please circle the statement out of each pair that reflects the most current thinking regarding the human brain. # Statement 1. A. How a brain develops depends solely on the genes you are born with. B. Brain development depends

  18. A Brain-to-Brain Interface for Real-Time Sharing of Sensorimotor Information

    E-Print Network [OSTI]

    Indiana University

    A Brain-to-Brain Interface for Real-Time Sharing of Sensorimotor Information Miguel Pais-Vieira1 Safra International Institute for Neuroscience of Natal (ELS-IINN), RN 59066-060, Natal, Brazil. A brain-to-brain the brains of two rats. In this BTBI, an ``encoder'' rat performed sensorimotor tasks that required

  19. Brain imaging methods used in experimental brain research such as Positron Emission Tomography (PET) and Functional

    E-Print Network [OSTI]

    Mueller, Klaus

    ABSTRACT Brain imaging methods used in experimental brain research such as Positron Emission and are best understood in the context of the underlying 3D brain anatomy. In this paper, we present a novel Brain Mapping, Functional Imaging 1 INTRODUCTION Although the human brain is no longer the black box

  20. Modeling of Human Brain Tissues and Head Injuries Induced by Blast and Ballistic Impact

    E-Print Network [OSTI]

    Kulkarni, Sahil G

    2013-11-07T23:59:59.000Z

    (Bilisik and Turhan, 2009). The ACH thus has a higher ballistic and impact protection capability than the PASGT helmet at a smaller weight. The ACH also has a pad system inside the helmet, replacing the nylon cord suspension system used in the PASGT... helmet with the PASGT helmet (Ivins et al., 2007) Problem Type Percentage of all ACH users (n = 535) Percentage of all PASGT users (n = 570) Loose Screws 11 1.8 Loose/Broken Straps 5.8 3.7 Hard/Loose pads 4.1 No padding Heat Retention 1.5 0...

  1. Brain glycogen - vestigial no more

    E-Print Network [OSTI]

    Swanson, RA; Swanson, RA

    2015-01-01T23:59:59.000Z

    between blood supply and energy demand in brain? Perhaps,re- sponses to the energy demands posed by the localized “energy supply to energy demand (Dienel and Cruz 2003). One

  2. Uptake of radiolabeled ions in normal and ischemia-damaged brain

    SciTech Connect (OSTI)

    Dienel, G.A.; Pulsinelli, W.A.

    1986-05-01T23:59:59.000Z

    The regional concentrations of nine radiochemicals were measured in rat brain after induction of cerebral ischemia to identify tracers concentrated by brain undergoing selective neuronal necrosis. Transient (30 minute) forebrain ischemia was produced in the rat; 24 hours after cerebral recirculation the radiochemicals were injected intravenously and allowed to circulate for 5 hours. The brain concentrations of the radiochemicals in dissected regions were determined by scintillation counting. Forebrain ischemia of this nature will produce extensive injury to striatal neurons but will spare the great majority of neocortical neurons at 24 hours. The regional concentrations of these radiochemicals varied considerably in both control and ischemic animals. In postischemic animals, 4 radionuclides (/sup 63/Ni, /sup 99/TcO/sub 4/, /sup 22/Na, and (/sup 3/H)tetracycline) were concentrated in the irreversibly damaged striatum in amounts ranging from 1.4 to 2.4 times greater than in normal tissue. The concentrations of /sup 65/Zn, /sup 59/Fe, /sup 32/PO/sub 4/, and /sup 147/Pm in postischemic brain were similar to or less than those in normal brain. The concentration of (14C)EDTA was increased in injured and uninjured brain of postischemic rats. Autoradiographic analysis of the distribution patterns of some of these ions in normal animals showed that /sup 99/TcO/sub 4/, /sup 22/Na, /sup 65/Zn, and /sup 59/Fe were distributed more uniformly throughout the brain than were /sup 32/PO/sub 4/, /sup 63/Ni, and /sup 147/Pm. At 24 or 48 hours after ischemia, /sup 63/Ni, /sup 99/TcO/sub 4/, and /sup 22/Na were preferentially concentrated in the damaged striatum and hippocampus, whereas /sup 65/Zn, /sup 59/Fe, /sup 32/PO/sub 4/, and /sup 147/Pm did not accumulate in irreversibly injured tissue. Of the radiochemicals tested to date, Ni, TcO/sub 4/, and tetracycline may be useful for diagnosing ischemic brain injury in humans, using positron emission tomography.

  3. How brain images reveal cognition : an ethnographic study of meaning-making in brain mapping practice

    E-Print Network [OSTI]

    Ala?, Morana

    2006-01-01T23:59:59.000Z

    cortical surface’, Human Brain Mapping, Volume 8, pp. 272-attention affects brain activity in Proc.Natl.Acad.Sci, USA,Atlas of the Human Brain, Stuttgart: Thieme. TOOTELL,

  4. Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors

    E-Print Network [OSTI]

    Wardak, Mirwais

    2013-01-01T23:59:59.000Z

    AB, Elson LM. The human brain coloring book. 1st ed. New21. Toga AW, Mazziotta JC. Brain mapping : the systems. SanSR, Phelps ME. Imaging Brain Function with Positron Emission

  5. Post-traumatic stress symptons, college adjustment, and drug use in response to trauma and the September 11th attacks

    E-Print Network [OSTI]

    Reck, Jennifer Kaye

    2013-02-22T23:59:59.000Z

    who are far-removed from an event can experience PTSD symptoms. Trauma has also been found to make adjustment to college more difficult and increase drug and alcohol use. Previous trauma can also adversely affect one's reaction to traumatic events...

  6. Microglial and neuronal abnormalities in the autistic brain

    E-Print Network [OSTI]

    Morgan, John T.

    2009-01-01T23:59:59.000Z

    G. , Dager, S. R. , 2002. Brain sructural abnormalities inwith autistic behavior. Brain Behav Immun 7, 97- Sparks, B.G. , Dager, S. R. , 2002. Brain sructural abnormalities in

  7. Potential Improvements in Shock-Mitigation Efficacy of a Polyurea-Augmented Advanced Combat Helmet

    E-Print Network [OSTI]

    Grujicic, Mica

    polyurea internal lining/external coating to the ACH shell. Effectiveness of different ACH designsTBI. Keywords Advanced Combat Helmet, internal lining/external coating, traumatic brain injury 1. Introduction that as advanced body armor and head protection gear have greatly reduced soldier fatalities from explosion

  8. CURRICULUM VITA Name: Jeffrey M. Love, PhD.

    E-Print Network [OSTI]

    Li, X. Rong

    ACTIVITY I. Publications Greve, K.W., Bianchini, K.J., Heinly, M.T., Love, J.M., Swift, D.A., & Ciota, M exposure to environmental and industrial toxins. Archives of Clinical Neuropsychology. Greve, K.W., Heinly Sorting Test in mild traumatic brain injury. The Clinical Neuropsychologist. Greve, K.W., Springer, S

  9. 1 USNCTAM 2010 16th US National Congress of Theoretical and Applied Mechanics

    E-Print Network [OSTI]

    Farritor, Shane

    effectiveness of helmet in mitigating early time blast induced mild traumatic brain injury. METHODOLOGY Two effectiveness of helmet. Figure 1 shows the configuration of setup. Figure 1 : Simulation setup. Frontal blast mismatch. Figure 3: Blast pressure Figure 4: Uderwash effect at air skull interface of the helmet Figure 4

  10. The estimation and use of predictions for the assessment of model performance using large samples with multiply imputed data

    E-Print Network [OSTI]

    Wood, Angela M.; Royston, Patrick; White, Ian R.

    2015-01-01T23:59:59.000Z

    outcome after traumatic brain injury: Development and international validation of prognostic scores based on admission characteristics. PLoS Medicine, 5, 1251–1261. Vergouw, D., Heymans, M.W., Peat, G.M., Kuijpers, T., Croft, P.R., de Vet, H.C.W., et...

  11. Overcoming the blood-brain barrier to taxane delivery for brain tumors and neurodegenerative diseases and brain tumors

    E-Print Network [OSTI]

    Rice, Antonie; Michaelis, Mary L.; Georg, Gunda I.; Liu, Yanbin; Turunen, Brandon; Audus, Kenneth L.

    2003-01-01T23:59:59.000Z

    vessels. After the perfusion, the rat was decapitated and the brain removed for sampling of various regions. The brain tissue was digested in Solvable for 24 hrs and the radioactivity quantified via liquid scintillation spectrometry. The capillary...

  12. BrainMap `95 workshop

    SciTech Connect (OSTI)

    NONE

    1995-12-31T23:59:59.000Z

    The fourth annual BrainMap workshop was held at La Mansion del Rio Hotel in San Antonio December 3--4, 1995. The conference title was ``Human Brain Mapping and Modeling.`` The meeting was attended by 137 registered participants and 30 observers from 82 institutions representing 12 countries. The meeting focused on the technical issues associated with brain mapping and modeling. A total of 23 papers were presented covering the following topics: spatial normalization and registration; functional image analysis; metanalysis and modeling; and new horizons in biological databases. The full program with abstracts was available on the Research Imaging Center`s web site. A book will be published by John Wiley and Sons prior to the end of 1998.

  13. A Note on Boltzmann Brains

    E-Print Network [OSTI]

    Yasunori Nomura

    2015-03-02T23:59:59.000Z

    Understanding the observed arrow of time is equivalent, under general assumptions, to explaining why Boltzmann brains do not overwhelm ordinary observers. It is usually thought that this provides a condition on the decay rate of every cosmologically accessible de Sitter vacuum, and that this condition is determined by the production rate of Boltzmann brains calculated using semiclassical theory built on each such vacuum. We argue, based on a recently developed picture of microscopic quantum gravitational degrees of freedom, that this thinking needs to be modified. In particular, depending on the structure of the fundamental theory, the decay rate of a de Sitter vacuum may not have to satisfy any condition except for the one imposed by the Poincare recurrence. The framework discussed here also addresses the question of whether a Minkowski vacuum may produce Boltzmann brains.

  14. Mind, Brain and Education as a Framework for Curricular Reform /

    E-Print Network [OSTI]

    Larrison, Abigail L.

    2013-01-01T23:59:59.000Z

    Eds. ). (2008). The educated brain. Cambridge: CambridgeM. M. & Gentile, D. A. (2011). Brains on video games. NatureA first course in mind, brain, and education. Mind, Brain, &

  15. The effects of alcohol and aspirin on neonatal brain development

    E-Print Network [OSTI]

    Beshear, Myra Dawn

    2013-02-22T23:59:59.000Z

    This study focuses on the effects of alcohol and aspirin on brain development in the neonatal rat. The period of brain development of particular interest is known as the brain growth spurt. Previous studies have shown that the developing brain...

  16. 2003 Nevada Test Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-05-23T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for the Nevada Test Site. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  17. 2007 Idaho National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-05-04T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  18. 2006 Pantex Plant Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-05-19T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  19. 2007 Hanford Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-07-16T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  20. 2007 Pantex Plant Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-07-31T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  1. 2010 Pantex Plant Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-06-29T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  2. 2010 Brookhaven National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-08-16T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  3. 2010 Savannah River Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-09-12T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  4. 2010 Argonne National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-06-20T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  5. 2006 Savannah River Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-08-20T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  6. 2010 Sandia National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-10-26T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  7. 2006 Kansas City Plant Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-06-13T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  8. 2006 Hanford Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-05-14T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  9. 2006 Brookhaven National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-03-06T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  10. 2007 Brookhaven National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-07-31T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  11. 2010 Idaho National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-09-26T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  12. 2006 Nevada Test Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-04-24T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  13. 2010 Hanford Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-10-05T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  14. 2010 Kansas City Plant Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-06-20T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  15. Type B Accident Investigation of the Subcontractor Employee Injuries...

    Broader source: Energy.gov (indexed) [DOE]

    Type B Accident Investigation of the Subcontractor Employee Injuries from a November 15, 2000, Fall Accident at the Oak Ridge National Laboratory Type B Accident Investigation of...

  16. Type B Accident Investigation of the August 22, 2000, Injury...

    Broader source: Energy.gov (indexed) [DOE]

    Type B Accident Investigation of the August 22, 2000, Injury Resulting From Violent Exothermic Chemical Reaction at the Portsmouth Gaseous Diffusion Plant, X-701B Site Type B...

  17. CORTICAL BRAIN SURFACE MAPPING FOR STUDYING PARTIAL VOLUME EFFECTS IN BRAIN FDG PET IMAGES

    E-Print Network [OSTI]

    Thompson, Paul

    CORTICAL BRAIN SURFACE MAPPING FOR STUDYING PARTIAL VOLUME EFFECTS IN BRAIN FDG PET IMAGES Hillary PET images is confounded by tissue atrophy and partial volume effects, especially in patients-based cortical brain surface mapping technique to account for partial volume effects on brain FDG PET images

  18. 5 Minute Brain Teaser Old vs. New Thinking Regarding the Human Brain*

    E-Print Network [OSTI]

    5 Minute Brain Teaser Old vs. New Thinking Regarding the Human Brain* Answer Key Answer Statement 1-B Brain development depends on the interplay between the genes you are born with and the experiences of the effects of genes and experiences on brain development. Is it the genetic make-up (nature) of a human

  19. Words in the brain: lexical determinants of word-induced brain activity

    E-Print Network [OSTI]

    Coulson, Seana

    Words in the brain: lexical determinants of word-induced brain activity Lee Osterhout*, Mark Allen Abstract Many studies have shown that open- and closed-class words elicit different patterns of brain. Introduction Is the brain response to words determined primarily by their linguistic functions

  20. Using Brain Weight to Predict Gestation in Mammals Bivariate Fit of Gestation By Brain Weight

    E-Print Network [OSTI]

    Carriquiry, Alicia

    1 Using Brain Weight to Predict Gestation in Mammals Bivariate Fit of Gestation By Brain Weight 0 100 200 300 400 500 Gestation 0 500 1000 1500 BrainWgt Linear Fit (All 50 mammals) Predicted Gestation = 85.248543 + 0.299867 Brain Weight Summary of Fit RSquare 0.372483 RSquare Adj 0.35941 Root Mean

  1. Brain-shift aware risk map for Deep Brain Stimulation Planning

    E-Print Network [OSTI]

    Boyer, Edmond

    Brain-shift aware risk map for Deep Brain Stimulation Planning Bilger Alexandre 1 , Essert Caroline / Université de Strasbourg, FRANCE Abstract. In Deep Brain Stimulation surgery, the eciency of the pro- cedure of the placement is dicult due to brain shifts occurring during and after the procedure. We propose an approach

  2. Adaptive Brain-Computer Interface Passive brain-computer interfaces are designed to use

    E-Print Network [OSTI]

    Boetticher, Gary D.

    Adaptive Brain-Computer Interface Abstract Passive brain-computer interfaces are designed to use brain activity as an additional input, allowing the adaptation of the interface in real time according to the user's mental state. While most current brain computer interface research (BCI) is designed for direct

  3. Brain imaging methods used in experimental brain research such as Positron Emission Tomography (PET) and Functional

    E-Print Network [OSTI]

    Mueller, Klaus

    ABSTRACT Brain imaging methods used in experimental brain research such as Positron Emission of methods create statistical parametric maps (SPMs) of the brain on a voxel- basis. In our approach, they are best understood in the context of the underly- ing 3-D brain anatomy. However, despite the power

  4. Playing with Your Brain: Brain-Computer Interfaces and Anton Nijholt

    E-Print Network [OSTI]

    Rajamani, Sriram K.

    Playing with Your Brain: Brain-Computer Interfaces and Games Anton Nijholt University of Twente role of brain-computer interaction in computer games and entertainment computing. The assumption is that brain activity, whether it is consciously controlled and directed by the user or just recorded in order

  5. Interspecies Avian Brain Chimeras Reveal That Large Brain Size Differences Are Influenced by Cell

    E-Print Network [OSTI]

    Jarvis, Erich D.

    Interspecies Avian Brain Chimeras Reveal That Large Brain Size Differences Are Influenced by Cell), and harvested the chimeras at later embryonic stages (between 9­12 days of incubation). The donor and host-C, Balaban E, Jarvis ED (2012) Interspecies Avian Brain Chimeras Reveal That Large Brain Size Differences

  6. Guest Editorial: Brain/Neuronal-Computer Game Interfaces and Interaction 1. Brain-Computer Games Interaction

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Guest Editorial: Brain/Neuronal-Computer Game Interfaces and Interaction 1. Brain-Computer Games are controlled through brain-computer interface (BCI) technology which requires sophisticated signal processing is a challenge being addressed by many researchers. Producing paradigms for training users to produce brain

  7. Brain Research and DLM: An overview

    E-Print Network [OSTI]

    Irby, Beverly J.; Lara-Alecio, Rafael

    2010-10-22T23:59:59.000Z

    Brain Research and DLM: An Overview Beverly J. Irby, Ed.D. Professor and Chair Sam Houston State University Rafael Lara-Alecio, Ph.D. Professor and Director Texas A&M University November 4, 2005 Basic Brain Information ? The brain research... us to ?see how mental functions map onto the brain structures? (Bruer, 1997, p. 4). Neuro- science and Education ? There are three well-established findings in developmental neurobiology: ? 1. Starting at infancy and continuing into later...

  8. Brain Surface Conformal Parameterization with Algebraic Functions

    E-Print Network [OSTI]

    Wang, Yalin

    Brain Surface Conformal Parameterization with Algebraic Functions Yalin Wang1,2 , Xianfeng Gu3 a brain surface to a multi-hole disk. The re- sulting parameterizations do not have any singularities of anatomical surfaces in MRI scans of the brain, in- cluding the hippocampi and the cerebral cortices

  9. Brain dynamics promotes function Carlos Lourenco

    E-Print Network [OSTI]

    Lisboa, Universidade Técnica de

    Brain dynamics promotes function Carlos Louren¸co 1 Faculty of Sciences of the University of Lisbon, 1049-001 Lisboa - Portugal Abstract. Dynamical structure in the brain promotes biological func- tion. Computational scientists have new opportunities to receive 'algorithmic' inspiration from brain processes

  10. Brain Organization and Computation Andreas Schierwagen

    E-Print Network [OSTI]

    Schierwagen, Andreas

    Brain Organization and Computation Andreas Schierwagen Institute for Computer Science, Intelligent://www.informatik.uni-leipzig.de/~schierwa Abstract. Theories of how the brain computes can be differentiated in three general conceptions systems approach. The discussion of key features of brain organization (i.e. structure with function

  11. Understanding complexity in the human brain

    E-Print Network [OSTI]

    Gazzaniga, Michael

    Understanding complexity in the human brain Danielle S. Bassett1 and Michael S. Gazzaniga2 1 the ultimate aim of neuroscientific enquiry is to gain an understanding of the brain and how its work- ings of mind­brain mechanisms if the cumulative findings from these neu- roscientific studies are coupled

  12. Brain Evolution Relevant to P. Thomas Schoenemann

    E-Print Network [OSTI]

    Schoenemann, P. Thomas

    Brain Evolution Relevant to Language P. Thomas Schoenemann James Madison University 1. Introduction The evolution of language obviously presupposes a brain that made language possible. At the same time, given of the human brain must have been language. Given that language is at least as much a cultural

  13. PUZZLING SYMPTOMS: EATING DISORDERS AND THE BRAIN

    E-Print Network [OSTI]

    Squire, Larry R.

    PUZZLING SYMPTOMS: EATING DISORDERS AND THE BRAIN A FAMILY GUIDE TO THE NEUROBIOLOGY OF EATING TO DO WITH THE BRAIN? Although people with eating disorders struggle to eat normally, this is only now believe that part of the problem has to do with how our brains process information about

  14. Bernard J. Baars How Brain Reveals Mind

    E-Print Network [OSTI]

    Memphis, University of

    Bernard J. Baars How Brain Reveals Mind Neural Studies Support the Fundamental Role of Conscious Experience Abstract: In the last decade, careful studies of the living brain have opened the way for human by seven cases: (1) the discovery of widespread brain activation during conscious perception; (2) high

  15. 1. Brain vs Computer Brian Whitworth

    E-Print Network [OSTI]

    Whitworth, Brian

    gates (McCulloch & Pitts, 1943) · The brain has input/output · 1012+ (thousand billion) neurons per head7/12/2011 1 1. Brain vs Computer © Brian Whitworth An Overview http://brianwhitworth.com 2 Aim Compare how computers process information vs how the brain process the senses? Define the main differences

  16. Children's Conceptions of the Brain 

    E-Print Network [OSTI]

    McColl, Judith

    2012-03-14T23:59:59.000Z

    The present study explored children’s developing conceptions of the brain in order to enhance previous research and to contribute to debates regarding the nature of children’s naïve biological theories. 56 participants aged 5, 7 and 9-years-old were...

  17. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    as: Ware et al. : Biomarkers of lung epithelial injury andN, Ware LB: Biomarkers in acute lung injury–marking forwardMA, May AK, Ware LB: Acute lung injury in patients with

  18. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury

    E-Print Network [OSTI]

    Sapru, Anil; Curley, Martha A.; Brady, Sandra; Matthay, Michael A.; Flori, Heidi

    2010-01-01T23:59:59.000Z

    pediatric patients with acute lung injury Abstract Purpose:in part at the mark of acute lung injury (ALI). Society fordistress syndrome Á Acute lung injury Á Clinical studies Á

  19. A novel strategy to activate cytoprotective genes in the injured brain

    SciTech Connect (OSTI)

    Zhao, Jing, E-mail: Jing.Zhao@uth.tmc.edu [Department of Neurobiology and Anatomy, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225 (United States)] [Department of Neurobiology and Anatomy, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225 (United States); Redell, John B., E-mail: John.B.Redell@uth.tmc.edu [Department of Neurobiology and Anatomy, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225 (United States); Moore, Anthony N., E-mail: Anthony.N.Moore@uth.tmc.edu [Department of Neurobiology and Anatomy, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225 (United States); Dash, Pramod K., E-mail: p.dash@uth.tmc.edu [Department of Neurobiology and Anatomy, The University of Texas Medical School, P.O. Box 20708, Houston, TX 77225 (United States)

    2011-04-15T23:59:59.000Z

    Highlights: {yields} A strategy to increase cytoprotective gene expression in injured tissue is outlined. {yields} A peptide containing a DEETGE motif can increase Nrf2 responsive genes in vivo. {yields} Gene expression in injured brains requires a calpain cleavage site. {yields} This peptide decreases BBB compromise when infused pre- or post-brain injury. {yields} Cleavage sites for disease-specific proteases could be used to treat that condition. -- Abstract: The transcription factor nuclear factor E2-related factor 2 (Nrf2) regulates the expression of multiple cytoprotective genes that have been shown to offer protection in response to a number of insults. The present study describes a novel strategy to increase expression of Nrf2-responsive genes in brain injured mice. Under normal conditions, the adapter protein Kelch-like ECH-associated protein 1 (Keap1) binds to Nrf2 and promotes its proteosomal degradation in the cytoplasm. The amino acid sequence DEETGE, located at amino acid 77-82 of Nrf2, is critical for Nrf2-Keap1 interaction, and synthetic peptides containing this sequence can be used to disrupt the complex in vitro. We observed that intracerebroventricular (i.c.v.) infusion of a peptide containing the DEETGE sequence along with the cell transduction domain of the HIV-TAT protein (TAT-DEETGE) into brain-injured mice did not increase the mRNA levels for Nrf2-driven genes. However, when a calpain cleavage sequence was introduced between the TAT sequence and the DEETGE sequence, the new peptide (TAT-CAL-DEETGE) increased the mRNA levels of these genes. Increased gene expression was not observed when the TAT-CAL-DEETGE peptide was injected into uninjured animals. Furthermore, injection of TAT-CAL-DEETGE peptides before or after brain injury reduced blood-brain barrier compromise, a prominent secondary pathology that negatively influences outcome. The present strategy to increase Nrf2-responsive gene expression can be adapted to treat other insults or diseases based on their underlying mechanism(s) of cellular damage.

  20. Version0109 THIS INJURY AND ILLNESS INCIDENT REPORT IS ONE

    E-Print Network [OSTI]

    Karsai, Istvan

    Version0109 THIS INJURY AND ILLNESS INCIDENT REPORT IS ONE OF THE FIRST FORMS THAT MUST BE FILLED's Form 301 ­ Injury and Illness Incident Report, should be completed as soon as possible after? ______________________ 10. Date of Accident __________________________ DESCRIPTIONOFTHEINJURY: 1. State name of machine

  1. E-Print Network 3.0 - acute hepatic injury Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: acute liver injury, inflammation, and fibrosis. During...

  2. Laminin ?2 fragments are increased in the circulation of patients with early phase acute lung injury

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    with early phase acute lung injury ing ?uids of patientsepithelial repair in acute lung injury—a translationalmatrix biology in the lung. Am J Physiol Lung Cell Mol

  3. Brain Prostheses as a Dynamic System (Immortalizing the Human Brain?)

    E-Print Network [OSTI]

    Vadim Astakhov; Tamara Astakhova

    2007-05-17T23:59:59.000Z

    Interest in development of brain prostheses, which might be proposed to recover mental functions lost due to neuron-degenerative disease or trauma, requires new methods in molecular engineering and nanotechnology to build artificial brain tissues. We develop a Dynamic Core model to analyze complexity of damaged biological neural network as well as transition and recovery of the system functionality due to changes in the system environment. We provide a method to model complexity of physical systems which might be proposed as an artificial tissue or prosthesis. Delocalization of Dynamic Core model is developed to analyze migration of mental functions in dynamic bio-systems which undergo architecture transition induced by trauma. Term Dynamic Core is used to define a set of causally related functions and Delocalization is used to describe the process of migration. Information geometry and topological formalisms are proposed to analyze information processes. A holographic model is proposed to construct dynamic environment with self-poetic Dynamic Core which preserve functional properties under transition from one host to another. We found statistical constraints for complex systems which conserve a Dynamic Core under environment transition. Also we suggest those constraints might provide recommendations for nanotechnologies and tissue engineering used in development of an artificial brain tissue.

  4. In the face of threat: neural and endocrine correlates of impaired facial emotion recognition in cocaine dependence

    E-Print Network [OSTI]

    Ersche, Karen D.; Hagan, Cindy C.; Smith, Dana G.; Jones, P. Simon; Calder, Andrew J.; Williams, Guy B.

    2015-01-01T23:59:59.000Z

    abuse. Exclusion criteria for all volunteers included a lifetime history of a psychotic disorder, neurological illness or traumatic head injury, an autoimmune or metabolic disorder, or HIV-infection. All volunteers consented in writing before being... . Participants then underwent whole brain T1-weighted MR scan at the Wolfson Brain Imaging Centre, University of Cambridge, UK. The MR images were acquired using a Siemens TIM-Trio 3T system with a magnetization-prepared rapid acquisition gradient-echo (MPRAGE...

  5. Brain Mapping Using Topology Graphs Obtained by Surface Segmentation

    E-Print Network [OSTI]

    Linsen, Lars

    Brain Mapping Using Topology Graphs Obtained by Surface Segmentation Fabien Vivodtzev1 , Lars@ucdavis.edu Summary. Brain mapping is a technique used to alleviate the tedious and time- consuming process of annotating brains by mapping existing annotations from brain atlases to individual brains. We introduce

  6. BEaST: Brain extraction using multiresolution nonlocal segmentation

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    BEaST: Brain extraction using multiresolution nonlocal segmentation Simon F. Eskildsen1 Østergaard2 , D. Louis Collins1 , and the Alzheimer's Disease Neuroimaging Initiative 1 McConnell Brain. Brain extraction is an important step in the analysis of brain images. Variability in brain morphology

  7. Center for BrainHealtH Scientific exploration at

    E-Print Network [OSTI]

    O'Toole, Alice J.

    Center for BrainHealtH #12;#12;Scientific exploration at BrainHealth is leading edge, innovative and transformative. leading tHe way in tHiS century'S greateSt ScientiFic cauSe The Center for Brain significant cause of the century: To understand, protect and heal the brain. Scientific exploration at Brain

  8. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Receptor Structures Key to Future Therapeutics Print With an aging population in America, it is more important than ever to discover ways to treat or prevent diseases...

  9. Imaging - Clearer brain scans ... | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Imaging - Clearer brain scans ... A clever signal noise reduction strategy developed by a team that includes Oak Ridge National Laboratory's Ben Lawrie could dramatically improve...

  10. Vulnerability of ex vivo ?-motor nerve terminals to hypoxia-reperfusion injury

    E-Print Network [OSTI]

    Baxter, Rebecca L.

    2010-01-01T23:59:59.000Z

    A growing body of evidence shows that presynaptic nerve terminals throughout the nervous system are vulnerable to a range of traumatic, toxic and disease-related neurodegenerative stimuli. The aim of this study was to further characterise...

  11. Reinforcement Learning in the brain Reading: Y Niv, Reinforcement learning in the brain, 2009.

    E-Print Network [OSTI]

    Seriès, Peggy

    basic types of animal conditioning animal learning) ow do these relate to RL? 20 Monday, 8 March 2010Reinforcement Learning in the brain · Reading: Y Niv, Reinforcement learning in the brain, 2009. wo Reinforcement learning and the brain: the problems we face all day · Decision making at all levels

  12. r Human Brain Mapping 000:000000 (2009) r Brain Structure and Obesity

    E-Print Network [OSTI]

    Thompson, Paul

    2009-01-01T23:59:59.000Z

    r Human Brain Mapping 000:000­000 (2009) r Brain Structure and Obesity Cyrus A. Raji,1,2y April J, School of Medicine, Pittsburgh, Pennsylvania r r Abstract: Obesity is associated with increased risk obesity and Type II diabetes, are associ- ated with specific patterns of brain atrophy. We used tensor

  13. Return of the Boltzmann brains

    SciTech Connect (OSTI)

    Page, Don N. [Institute for Theoretical Physics, Department of Physics, University of Alberta, Room 238 CEB, 11322-89 Avenue, Edmonton, Alberta, CT6G 2G7 (Canada)

    2008-09-15T23:59:59.000Z

    Linde in J. Cosmol. Astropart. Phys. 01 (2007) 022 shows that some (though not all) versions of the global (volume-weighted) description avoid the 'Boltzmann brain' problem raised by Page [Phys. Rev. D 78, 063535 (2008)] if the universe does not have a decay time less than 20 Gyr. Here I give an apparently natural version of the volume-weighted description in which the problem persists, highlighting the ambiguity of taking the ratios of infinite volumes that appear to arise from eternal inflation.

  14. Type B Accident Investigation Of The February 25, 2009 Injury...

    Energy Savers [EERE]

    To A Passenger In An Electric Cart At The Waste Isolation Pilot Plant, Carlsbad, New Mexico Type B Accident Investigation Of The February 25, 2009 Injury To A Passenger In An...

  15. Shoulder injury reduction with post-offer testing

    E-Print Network [OSTI]

    Harbina, Gary L.; Shenoy, Catherine; Garcia, Amy; Olson, John C.

    2011-06-21T23:59:59.000Z

    . Methods: A physical capacity evaluation based testing protocol was utilized to determine if each new employee had the physical work capacity to perform the job for which they were hired. Injuries to the shoulder were specifically scrutinized...

  16. Role of myeloid Hif-1? in acute lung injury 

    E-Print Network [OSTI]

    MacDuff, Andrew

    2011-07-05T23:59:59.000Z

    Acute Lung Injury, characterised clinically as the Acute Respiratory Distress Syndrome is a catastrophic response to a range of pulmonary and non-pulmonary insults. Despite much work the key mechanisms involved in generating the exaggerated immune...

  17. athletic injuries: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    stress-response research (more) Newcomer, R. Renee. 2000-01-01 3 Injuries to the Head We have all heard of athletes, particularly Physics Websites Summary: after a...

  18. Ultrasound-Enhanced Drug Transport and Distribution in the Brain

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    enhanced taxol delivery in brain tumor patients usingopening of the blood–brain barrier in rabbits. Radiology.and Distribution in the Brain Ying Liu, 1 Sumit Paliwal, 2

  19. Genetic associations with brain cortical thickness in multiple sclerosis

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    onset of multiple sclerosis. Brain 131, 808–817. Georgala,in multiple sclerosis. Brain 126, Shannon, P. , Markiel,Genes, Brain and Behavior (2015) 14: 217–227 doi:

  20. Wakate-Initiative Seminar Memory formation in the fly brain!

    E-Print Network [OSTI]

    Ejiri, Shinji

    Wakate-Initiative Seminar Memory formation in the fly brain! Dr. Hiromu Tanimoto Head is synthesized in ~280 neurons in the fly brain and involved also in other brain functions, it is important

  1. Local drug delivery for treatment of brain tumor associated edema

    E-Print Network [OSTI]

    Ong, Qunya

    2014-01-01T23:59:59.000Z

    Brain tumor associated edema, a common feature of malignant brain neoplasms, is a significant cause of morbidity from brain tumor. Systemic administration of corticosteroids, the standard of care, is highly effective but ...

  2. Intraoperative Brain Tumor Resection Cavity Characterization with Conoscopic Holography

    E-Print Network [OSTI]

    Webster III, Robert James

    Intraoperative Brain Tumor Resection Cavity Characterization with Conoscopic Holography Amber L ABSTRACT Brain shift compromises the accuracy of neurosurgical image-guided interventions if not corrected approach to correcting for brain shift. Laser range scan, instrument swabbing, and conoscopic holography

  3. A Hybrid Brain-computer Interface for Intelligent Prosthetics

    E-Print Network [OSTI]

    Cheng, Yu-Che

    2014-12-09T23:59:59.000Z

    Over the past few decades, many researcher have shown that human can use brain signals to communicate with computers or machines by using brain-computer interfaces (BCIs). BCI systems can measure the brain activity and translate them into control...

  4. ameliorates organ injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 32...

  5. attenuates hepatocellular injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 48 THE...

  6. anal sphincter injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 132...

  7. attenuate organ injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 42 THE...

  8. acid chemical injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 55...

  9. artery injury complicating: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 68...

  10. abdominal injuries: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 30 Depression...

  11. attenuates renal injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 64 THE...

  12. accidental macular injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 78 Effect of...

  13. actute kidney injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 62...

  14. airway injury effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 137 Etiology...

  15. ameliorates reperfusion injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 65...

  16. abdominal organ injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 36 Depression...

  17. ameliorates hepatocellular injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 40...

  18. abrogating liver injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 59 In vitro...

  19. ameliorates renal injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 57...

  20. attenuates oxidant injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 56 THE...

  1. alkaline chemical injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 42...

  2. ay 1 Mysteries of Brain : Come and `learn about the brain'. Have you wondered, "What is our brain like?" "How do we sense things around us?" and "How do we react to our environment?"

    E-Print Network [OSTI]

    Narayanan, H.

    of Brain : Come and `learn about the brain'. Have you wondered, "What is our brain like?" "How do we sense about `neuron' as a basic unit of the brain, structure of the brain, functions closely associated with brain lobes and hemispheres and understanding the nervous system Special Focus: Brain Hemispheres

  3. 2007 Kansas City Plant Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-07-13T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  4. 2008 Sandia National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-09-17T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  5. 2008 Nevada Test Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-10-05T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  6. 2009 Argonne National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2010-08-19T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  7. 2008 Kansas City Plant Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-09-22T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  8. 2009 Hanford Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2010-12-01T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  9. 2008 Idaho National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2010-11-23T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  10. 2009 Pantex Plant Annual Illness and Injury Surveillance

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2010-12-15T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  11. 2007 Sandia National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-02-04T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  12. 2008 Brookhaven National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-12-10T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  13. 2009 Brookhaven National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2010-11-24T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  14. 2008 Savannah River Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-09-29T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  15. 2007 Savannah River Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-05-05T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  16. 2007 Nevada Test Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-06-30T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  17. Outcomes After Whole Brain Reirradiation in Patients With Brain Metastases

    SciTech Connect (OSTI)

    Son, Christina H. [School of Medicine, Duke University, Durham, NC (United States); Jimenez, Rachel; Niemierko, Andrzej; Loeffler, Jay S.; Oh, Kevin S. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Shih, Helen A., E-mail: hshih@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States)

    2012-02-01T23:59:59.000Z

    Purpose: Patients with brain metastases are often treated with whole brain radiation therapy (WBRT) for purposes of palliation. The treatment of those who experience subsequent intracranial disease progression can include a second course of WBRT, although there is controversy surrounding its safety and efficacy. This study examines the outcomes in patients at Massachusetts General Hospital who underwent reirradiation. Patients and Methods: We examined the medical records of 17 patients at Massachusetts General Hospital with brain metastases who were initially treated with WBRT between 2002 and 2008 and were subsequently retreated with a second course of WBRT. The median dose for the first course of WBRT was 35 Gy (range, 28-40 Gy), with a fraction size of 2 to 3 Gy (median, 2.5 Gy). The median dose at reirradiation was 21.6 Gy (range, 14-30 Gy), with a fraction size of 1.5 to 2 Gy (median, 1.8 Gy). Results: The second course of WBRT was administered upon radiographic disease progression in all patients. Of 10 patients with complete follow-up data, 8 patients experienced complete or partial symptom resolution, and 2 did not show clinical improvement. The time to radiographic progression was 5.2 months. The median overall survival for all patients after diagnosis of metastases was 24.7 months. The median survival time after initiation of reirradiation was 5.2 months (95% CI, 1.3-8.7). In 6 patients with stable extracranial disease, the median survival time after retreatment was 19.8 months (95% CI, 2.7-{infinity}), compared with 2.5 months (95% CI, 0.8-5.5) for those with extracranial disease progression (p = 0.05). Acute adverse reactions occurred in 70.5% of patients but were mild to moderate in severity. Conclusion: In select patients and especially those with stable extracranial disease, reirradiation may be an appropriate and effective intervention to provide symptomatic relief and slow intracranial disease progression. Side effects were minimal and did not cause substantial changes in quality of life.

  18. STOCHASTIC GENERATION OF BIOLOGICALLY ACCURATE BRAIN NETWORKS

    E-Print Network [OSTI]

    STOCHASTIC GENERATION OF BIOLOGICALLY ACCURATE BRAIN NETWORKS A Thesis by ARAVIND ALURI Submitted OF BIOLOGICALLY ACCURATE BRAIN NETWORKS A Thesis by ARAVIND ALURI Submitted to the Office of Graduate Studies Head of Department, Valerie Taylor December 2005 Major Subject: Computer Science #12;iii ABSTRACT

  19. From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood-brain barrier?

    E-Print Network [OSTI]

    Liu, Linan; Eckert, Mark A; Riazifar, Hamidreza; Kang, Dong-Ku; Agalliu, Dritan; Zhao, Weian

    2013-01-01T23:59:59.000Z

    and function of the blood-brain barrier,” Neurobiology ofV. Zlokovic, “The blood-brain barrier in health and chroniccell biology of the blood- brain barrier,” Annual Review of

  20. arterial baroreflex sensitivity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Injury University of California eScholarship Repository Summary: minimize secondary brain injury after head trauma. Critical1996). Avoiding secondary brain injury after...

  1. Mapping protein abundance patterns in the brain using voxelation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    protein abundance patterns in the brain using voxelation combined with liquid chromatography and mass spectrometry. Mapping protein abundance patterns in the brain using voxelation...

  2. Characterization of the Mouse Brain Proteome Using Global Proteomic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brain Proteome Using Global Proteomic Analysis Complemented with Cysteinyl-Peptide Enrichment. Characterization of the Mouse Brain Proteome Using Global Proteomic Analysis...

  3. Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    with established acute lung injury. Respiratory Researchof patients with acute lung injury. Predictors of mortality.of mortality in acute lung injury during the era of lung

  4. The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    MANUSCRIPT The role of whole brain radiation therapy in themanagement of newly diagnosed brain metastases: a systematicNeurosurgery, Iowa Spine and Brain Institute, Iowa City, IA,

  5. Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals

    E-Print Network [OSTI]

    Mon, A; Durazzo, TC; Gazdzinski, S; Hutchison, KE; Pennington, DL; Meyerhoff, DJ

    2013-01-01T23:59:59.000Z

    PA Author Manuscript Genes Brain Behav. Author manuscript;TH. Association between brain-derived neurotrophic factorgene polymorphism and progressive brain volume changes in

  6. Neuronal and network computation in the brain

    SciTech Connect (OSTI)

    Babloyantz, A. [Center for Study of Non-linear Systems, Universite Libre de Bruxelles, CP 231, Boulevard du Triomphe, 1050 Brussels (Belgium); International Solvay Institutes for Physics and Chemistry, ULB-Campus Plaine-CP 231, Boulevard du Triomphe, 1050 Brussels (Belgium)

    1999-03-22T23:59:59.000Z

    The concepts and methods of non-linear dynamics have been a powerful tool for studying some gamow aspects of brain dynamics. In this paper we show how, from time series analysis of electroencepholograms in sick and healthy subjects, chaotic nature of brain activity could be unveiled. This finding gave rise to the concept of spatiotemporal cortical chaotic networks which in turn was the foundation for a simple brain-like device which is able to become attentive, perform pattern recognition and motion detection. A new method of time series analysis is also proposed which demonstrates for the first time the existence of neuronal code in interspike intervals of coclear cells.

  7. A Brain-Switch using Riemannian Geometry A. Barachant1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    A Brain-Switch using Riemannian Geometry A. Barachant1 , S. Bonnet1 , M. Congedo2 , C. Jutten2 1 the issue of asynchronous brain-switch. The detection of a specific brain pattern from the ongoing EEG-time EEG segments contain all the desired information. Such a brain-switch is valuable as it is easy to set

  8. Brain donation is one of the most important contributions to

    E-Print Network [OSTI]

    Contractor, Anis

    01-19-09 Brain donation is one of the most important contributions to research. Brain donations 200 brain tissue samples to researchers. Some of the major findings that came about through utilization of this precious gift include: In 2006, Todd Preuss and his team showed that certain brain

  9. The brain: What is critical about it? Dante R. Chialvo

    E-Print Network [OSTI]

    Chialvo, Dante R.

    The brain: What is critical about it? Dante R. Chialvo , Pablo Balenzuela and Daniel Fraiman the recent proposal that the most fascinating brain properties are related to the fact that it always stays results, as well as further implications of this view of the functioning brain. Keywords: Brain, critical

  10. Zo Rebecca Hunter Plasticity of the adult human brain

    E-Print Network [OSTI]

    Kallenrode, May-Britt

    Zoë Rebecca Hunter Plasticity of the adult human brain and motor recovery after stroke PICS © Institute of Cognitive Science #12;1 Bachelor's Thesis Plasticity of the adult human brain and motor brain and motor recovery after stroke 2 Abstract Stroke may cause a major destruction of brain tissue

  11. The Noisy Brain: Stochastic Dynamics as a Principle of

    E-Print Network [OSTI]

    Rolls, Edmund T.

    The Noisy Brain: Stochastic Dynamics as a Principle of Brain Function Edmund T. Rolls Oxford Centre random spiking times of individual neurons produce a source of noise in the brain. The aim of this book is to consider the effects of this and other noise on brain pro- cessing. We show that in cortical networks

  12. Doppler Ultrasound Driven Biomechanical Model of the Brain for

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Doppler Ultrasound Driven Biomechanical Model of the Brain for Intraoperative Brain of the target is essential to reduce mor- bidity during brain tumor removal interventions. Yet, image-guided neu- rosurgery faces an important issue for large skull openings where brain soft-tissues can exhibit large

  13. Norme Attuative della Cognitive and Brain Sciences Doctoral School

    E-Print Network [OSTI]

    1 Norme Attuative della Cognitive and Brain Sciences Doctoral School Executive Regulations of the Cognitive and Brain Sciences Doctoral School Norme Attuative della Scuola di Dottorato in Cognitive and Brain Sciences Executive Regulations of the Cognitive and Brain Sciences Doctoral School Approvate nella

  14. Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction ¿ a randomised placebo-controlled trial (KARE): study protocol

    E-Print Network [OSTI]

    Cross, Laurence JM; O’Kane, Cecilia M; McDowell, Cliona; Elborn, Jospeh J; Matthay, Michael A; McAuley, Daniel F

    2013-01-01T23:59:59.000Z

    growth factor in acute lung injury to reduce pulmonaryV, Matthay MA: Acid-induced lung injury. Protective effectof patients with acute lung injury and the acute respiratory

  15. Where Brain, Body and World Collide 

    E-Print Network [OSTI]

    Clark, Andy

    1998-01-01T23:59:59.000Z

    The brain fascinates because it is the biological organ of mindfulness itself. It is the inner engine that drives intelligent behavior. Such a depiction provides a worthy antidote to the once-popular vision of the mind as ...

  16. Nanotools for Neuroscience and Brain Activity Mapping

    E-Print Network [OSTI]

    Alivisatos, A. Paul

    Neuroscience is at a crossroads. Great effort is being invested into deciphering specific neural interactions and circuits. At the same time, there exist few general theories or principles that explain brain function. We ...

  17. Network induces burst synchronisation in cat brain

    E-Print Network [OSTI]

    Ewandson L. Lameu; Fernando S. Borges; Rafael R. Borges; Antonio M. Batista; Murilo S. Baptista; Ricardo L. Viana

    2015-03-07T23:59:59.000Z

    The brain of mammals are divided into different cortical areas that are anatomically connected forming larger networks which perform cognitive tasks. The cat cerebral cortex is composed of 65 areas organised into the visual, auditory, somatosensory-motor and frontolimbic cognitive regions. We have built a network of networks, in which networks are connected among themselves according to the connections observed in the cat cortical areas aiming to study how inputs drive the synchronous behaviour in this cat brain-like network. We show that without external perturbations it is possible to observe high level of bursting synchronisation between neurons within almost all areas, except for the auditory area. Bursting synchronisation appears between neurons in the auditory region when an external perturbation is applied in another cognitive area. This is a clear evidence that pattern formation and collective behaviour in the brain might be a process mediated by other brain areas under stimulation.

  18. BE 780: Brain Machine Interfaces Spring 2013

    E-Print Network [OSTI]

    Vajda, Sandor

    BE 780: Brain Machine Interfaces Spring 2013 Instructor: Jason Ritt the readings for an assigned class. Homework 30% Mid-semester Report 30, code, or files of any kind. Reports and final projects must

  19. Injury experience in stone mining, 1991. Information report

    SciTech Connect (OSTI)

    Not Available

    1993-10-01T23:59:59.000Z

    This Mine Safety and Health Administration (MSHA) informational report reviews in detail the occupational injury and illness experience of stone mining in the united States for 1991. Data reported by operators of mining establishments concerning work injuries are summarized by work location, accident classification, part of body injured, nature of injury, occupation, and principal type of mineral. Related information on employment, worktime, and operating activity also is presented. Data reported by independent contractors performing certain work at mining locations are depicted separately in this report. For ease of comparison with other metal and nonmetallic mineral mining industries and with coal mining, summary reference tabulations are included at the end of both the operator and the contractor sections of this report.

  20. Brain Cluster Leiden -InventoryBrain Cluster Leiden -Inventory Inventory of organizations working inInventory of organizations working in

    E-Print Network [OSTI]

    Galis, Frietson

    Brain Cluster Leiden - InventoryBrain Cluster Leiden - Inventory Inventory of organizations working brain Annelieke Hoenderkamp Leiden Bio Science Park foundation in assignment of Municipality of Leiden November 2011 #12;IntroductionIntroduction · The brain is the most complex organ in the human body. Its

  1. Abstract--Recent brain imaging studies on primates revealed that a network of brain areas is activated both during

    E-Print Network [OSTI]

    Trahanias, Panos

    9 Abstract-- Recent brain imaging studies on primates revealed that a network of brain areas and constitutes an efficient behavior of mammals. Recent brain imaging studies investigate where and how observed to this direction [23]. Additional studies [10],[16] indicate the existence of a much wider network of brain areas

  2. Brain Research and DLM: An overview 

    E-Print Network [OSTI]

    Irby, Beverly J.; Lara-Alecio, Rafael

    2010-10-22T23:59:59.000Z

    of months of age, babies can process the emotional contours of language (prosody), which means they tune in to the emotional variations in your voice. (In fact, toddlers can memorize nursery rhymes because rhymes have prosody!) As the preschool teacher... time periods (Markezich, n.d.) So, what does this mean? ? The brain knows how to developmentally scaffold itself. For example, in Broca's area, the region in the brain for language production, it has been determined that when this becomes...

  3. INTRODUCTION Acute lung injury is characterized by lesions of both lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    INTRODUCTION Acute lung injury is characterized by lesions of both lung endothelial and alveolar collagenase (Pardo et al., 1997). The latter was increased following acute lung injury induced by hyperoxia

  4. Type XVIII collagen is essential for survival during acute liver injury in mice

    E-Print Network [OSTI]

    Duncan, Michael B.

    The regenerative response to drug- and toxin-induced liver injury induces changes to the hepatic stroma, including the extracellular matrix. Although the extracellular matrix is known to undergo changes during the injury ...

  5. Understanding human-space suit interaction to prevent injury during extravehicular activity

    E-Print Network [OSTI]

    Anderson, Allison P. (Allison Paige)

    2014-01-01T23:59:59.000Z

    Extravehicular Activity (EVA) is a critical component of human spaceflight. Working in gas-pressurized space suits, however, causes fatigue, unnecessary energy expenditure, and injury. The problem of injury is particularly ...

  6. The role of stress in recovery of function after spinal cord injury

    E-Print Network [OSTI]

    Washburn, Stephanie Nicole

    2009-05-15T23:59:59.000Z

    Research has shown that exposure to just 6 minutes of uncontrollable shock 24 hours following contusion injury impairs locomotor recovery and leads to greater tissue loss at the injury epicenter. Uncontrollable shock is known to elevate...

  7. Effects of Surgical Repair or Reconstruction on Radiocarpal Mechanics from Wrists with Scapholunate Ligament Injury

    E-Print Network [OSTI]

    Johnson, Joshua

    2013-05-31T23:59:59.000Z

    Osteoarthritis as a result of injury/trauma is a significant problem, and there is still a need to develop tools for evaluating joint injuries and the effectiveness of surgical treatments. For the wrist in particular, ...

  8. Moderators of the Safety Climate-Injury Relationship: A Meta-Analytic Examination

    E-Print Network [OSTI]

    Beus, Jeremy M.

    2010-07-14T23:59:59.000Z

    This study examined the variability in the observed relationship between safety climate and injuries in the extant literature by meta-analytically examining possible moderators of the safety climate-injury relationship at both the individual...

  9. Central Nervous System Injury, Neurocognitive and Quality of Life Outcomes in Children with Brain Tumors Treated with Chemotherapy

    E-Print Network [OSTI]

    Baron Nelson, Mary Christine

    2012-01-01T23:59:59.000Z

    treatment for acute lymphoblastic leukemia. Biol Res Nurs,children with acute lymphoblastic leukemia. Biol Res Nurs,of childhood acute lymphocytic leukemia. J Pediatr Psychol,

  10. Central Nervous System Injury, Neurocognitive and Quality of Life Outcomes in Children with Brain Tumors Treated with Chemotherapy

    E-Print Network [OSTI]

    Baron Nelson, Mary Christine

    2012-01-01T23:59:59.000Z

    treatment for acute lymphoblastic leukemia. Biol Res Nurs,children with acute lymphoblastic leukemia. Biol Res Nurs,in childhood acute lymphoblastic leukemia. Journal of

  11. Systemic, local, and imaging biomarkers of brain injury: more needed, and better use of those already established?

    E-Print Network [OSTI]

    Carpenter, Keri L. H.; Czosnyka, Marek; Jalloh, Ibrahim; Newcombe, Virginia F. J.; Helmy, Adel; Shannon, Richard J.; Budohoski, Karol P.; Kolias, Angelos G.; Kirkpatrick, Peter J.; Carpenter, Thomas Adrian; Menon, David K.; Hutchinson, Peter J.

    2015-02-18T23:59:59.000Z

    anisotropy; FDG, 18F-fluorodeoxyglucose; FLAIR, fluid-attenuated inversion recovery; GABA, gamma-aminobutyric acid; GCS, Glas- gow coma scale score; GFAP, glial fibrillary acidic protein; GOS, Glasgow outcome scale score; GE, gradient echo; GRE, gradient... dehydrogenase; LPR, lac- tate/pyruvate ratio; MMP, matrix metalloprotease; MRI, magnetic resonance imag- ing; MRS, magnetic resonance spectroscopy; NAA, N -acetylaspartate; NAAG, N - acetylaspartylglutamate; NAD+, nicotine adenine dinucleotide (oxidized form...

  12. A nonlinear dynamical theory of cell injury Donald J DeGracia1

    E-Print Network [OSTI]

    DeGracia, Donald J.

    A nonlinear dynamical theory of cell injury Donald J DeGracia1 , Zhi-Feng Huang2 and Sui Huang3 1 differential equations describing a theory of cell injury dynamics. A mutual antagonism between injury-death trajectory to a pro-survival trajectory on bistable phase planes. The model plausibly explains why laboratory

  13. BRAIN, BEHAVIOUR AND NEUROIMAGING A seminar to create awareness about the mysteries of the brain

    E-Print Network [OSTI]

    Narayanan, H.

    BRAIN, BEHAVIOUR AND NEUROIMAGING A seminar to create awareness about the mysteries of the brain Srinivasan Professor & Head, Centre of Behavioural and Cognitive Sciences, University of Allahabad.D. Head of Department, Physiology, S.M.S. Medical College, Jaipur Psychology and Police investigations Mr

  14. New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc

    E-Print Network [OSTI]

    Corona, C; Pensalfini, A; Frazzini, V; Sensi, S L

    2011-01-01T23:59:59.000Z

    39;s disease: brain deregulation of calcium and zinc [39;s disease: brain deregulation of calcium and zinc39;s disease: brain deregulation of calcium and zinc Gotz

  15. Tsunami-related injury in Aceh Province, Indonesia * C. Robinsona

    E-Print Network [OSTI]

    Scharfstein, Daniel

    Tsunami-related injury in Aceh Province, Indonesia S. Doocya * C. Robinsona , C. Moodieb and G; Indonesia Introduction The 2004 Asian tsunami resulted in over 175,000 deaths, nearly 50,000 missing, and over 1.7 million people displaced in the Indian Ocean region (USAID 2005). Indonesia's Aceh Province

  16. Ankle Injuries Approved by the UHS Patient Education Committee

    E-Print Network [OSTI]

    and to lessen the chance of re-injury. Ice: Use ice (in a plastic bag, ice bag or cold pack) for 15 to 20 of fabric, such as a pillowcase, between the ice bag and your skin. After 48 hours, continue to ice 2 to 4

  17. Ankle Injuries Approved by the UHS Patient Education Committee

    E-Print Network [OSTI]

    Yener, Aylin

    bag, ice bag or cold pack) for 15 to 20 minutes every 1 to 2 hours during the first 48 hours after in activities requiring sudden movements and turns until you can run without pain. Ice: Use ice (in a plastic your injury. You should place a thin layer of fabric, such as a pillowcase, between the ice bag

  18. Childhood Agricultural Injury Prevention in the U.S.A.

    E-Print Network [OSTI]

    #12;Childhood Agricultural Injury Prevention in the U.S.A. Presentation for the Swedish University of Agricultural Sciences Barbara Lee, PhD National Farm Medicine Center National Children's Center for Rural and Agricultural Health and Safety Marshfield, WI USA October 2011 #12;#12;#12;Outline · Background · Child Ag

  19. INJURY AND ILLNESS PREVENTION PROGRAM This Injury and Illness Prevention Program has been prepared by the University of California,

    E-Print Network [OSTI]

    Guo, Ting

    methods: Standard Operating Procedures Manual (laboratory specific and available on SmartSite) Safety Data with University Policy (UCD Policy & Procedure Manual Section 290-15: Safety Management Program) and California for the implementation and maintenance of the Injury and Illness Prevention Program (IIPP) is in accordance

  20. Genetic associations with brain cortical thickness in multiple sclerosis

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    Genome Res 13, 2498–2504. Stirling, D.P. & Stys, P.K. (2010)results in axonal injury (Stirling & Stys 2010). In supe-

  1. Approaching Injury and Violence Prevention through Public Health Policy: A Window of Opportunity to Renew Our Focus

    E-Print Network [OSTI]

    Degutis, Linda C

    2011-01-01T23:59:59.000Z

    our largest external research grantees, the Injury Controland state health department grantees are actively engaged in

  2. miRNAs in brain development

    SciTech Connect (OSTI)

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan, E-mail: johan.jakobsson@med.lu.se

    2014-02-01T23:59:59.000Z

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  3. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find FindRewindParticleBorncelebrates itsBradyBrainBrain

  4. BigNeuron: Unlocking the Secrets of the Human Brain

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    BigNeuron: Unlocking the Secrets of the Human Brain BigNeuron: Unlocking the Secrets of the Human Brain Berkeley Researchers and Supercomputers to Help Create a Standard 3D Neuron...

  5. The formation and function of the brain ventricular system

    E-Print Network [OSTI]

    Chang, Jessica T. (Jessica Tzung-Min)

    2012-01-01T23:59:59.000Z

    The brain ventricular system is composed of a highly conserved set of cavities that contain cerebrospinal fluid (CSF), a protein-rich fluid essential for brain function. However, little is known about the function of ...

  6. 9.14 Brain Structure and Its Origins, Spring 2009

    E-Print Network [OSTI]

    Schneider, Gerald E.

    Outline of mammalian functional neuroanatomy, aided by studies of comparative neuroanatomy and evolution, and of brain development. Topics include early steps to a central nervous system, basic patterns of brain and spinal ...

  7. Differeneces in Brain Responses Between Lean and Obese Women to a Sweetened Drink

    E-Print Network [OSTI]

    Connolly, Lynn Shapiro

    2012-01-01T23:59:59.000Z

    Activation in brain energy regulation and reward centers byActivation in brain energy regulation and reward centers by

  8. Chemically-selective imaging of brain structures with CARS microscopy

    E-Print Network [OSTI]

    Xie, Xiaoliang Sunney

    Chemically-selective imaging of brain structures with CARS microscopy Conor L. Evans1§ , Xiaoyin Xu anti-Stokes Raman scattering (CARS) microscopy to image brain structure and pathology ex vivo. Although. Definitive diagnosis still requires brain biopsy in a significant number of cases. CARS microscopy

  9. DISCOVERING BRAIN MECHANISMS AND THE RULES OF MOLECULAR

    E-Print Network [OSTI]

    Stengel, Robert F.

    DISCOVERING BRAIN MECHANISMS AND THE RULES OF MOLECULAR BIOLOGY Paul Shapshak, PhD*1 and Robert-324-2723 ABSTRACT The human genome has approximately 30,000 genes. Brain cells express at least 15,000. The human brain is subject to many acute and chronic diseases including viral encephalitis, AIDS/HIV Associated

  10. Human brain cancer studied by resonance Raman spectroscopy

    E-Print Network [OSTI]

    Sun, Yi

    Human brain cancer studied by resonance Raman spectroscopy Yan Zhou Cheng-Hui Liu Yi Sun Yang Pu://biomedicaloptics.spiedigitallibrary.org/ on 11/16/2012 Terms of Use: http://spiedl.org/terms #12;Human brain cancer studied by resonance Raman of human brain tissues are examined using a confocal micro-Raman system with 532-nm excitation in vitro

  11. and the Brain Sound may seem a straightforward physical phenom-

    E-Print Network [OSTI]

    Hill, Wendell T.

    Hearing and the Brain Sound may seem a straightforward physical phenom- enon, whose waves can be recorded, charted and parsed. But no machines can do what the human brain does--understand a wide variety of electrical and computer engineering and member of the Institute for Systems Research, studies how the brain

  12. The brain near the edge Dante R. Chialvo

    E-Print Network [OSTI]

    Chialvo, Dante R.

    The brain near the edge Dante R. Chialvo Department of Physiology, Feinberg Medical School grain, the brain seems a relatively small dynamical system composed by a few dozen interacting areas that some of the most fundamental properties of the functioning brain are possible because

  13. Brain donation is one of the most important contributions to

    E-Print Network [OSTI]

    Contractor, Anis

    01-19-09 Brain donation is one of the most important contributions to research. As researchers work to better understand disorders that affect mental function with aging, brain donations are essential to their progress. By studying the anatomy, pathology, and chemistry of the brains of people with memory problems

  14. BRAIN AND SURFACE WARPING VIA MINIMIZING LIPSCHITZ EXTENSIONS

    E-Print Network [OSTI]

    BRAIN AND SURFACE WARPING VIA MINIMIZING LIPSCHITZ EXTENSIONS By Facundo M´emoli Guillermo Sapiro­0436 Phone: 612/624-6066 Fax: 612/626-7370 URL: http://www.ima.umn.edu #12;Brain and Surface Warping via connection with the infinity Laplacian, a computational framework for surface warping and in particular brain

  15. ELSEVIER Brain Research 712 (1996) 293-298 Research report

    E-Print Network [OSTI]

    Tepper, James M.

    BRAIN RESEARCH ELSEVIER Brain Research 712 (1996) 293-298 Research report Local infusion of brain examined the effects of local infusion of BDNF on the electrophysioiogical activity of serotonergic neurons in the rat dorsal raph6 nucleus with extracellular single unit recording in vivo. Compared with vehicle-infused

  16. Scale-Free Brain Functional Networks Victor M. Eguiluz,1

    E-Print Network [OSTI]

    Oro, Daniel

    Scale-Free Brain Functional Networks Victor M. Egui´luz,1 Dante R. Chialvo,2 Guillermo A. Cecchi,3 is used to extract functional networks connecting correlated human brain sites. Analysis of the resulting-world networks, reflect important functional information about brain states. DOI: 10.1103/PhysRevLett.94

  17. UNSUPERVISED SEGMENTATION FOR AUTOMATIC DETECTION OF BRAIN TUMORS IN MRI

    E-Print Network [OSTI]

    Lefèvre, Sébastien

    a pre-segmentation to ex- tract the brain from the head. Then, a second segmentation is done insideUNSUPERVISED SEGMENTATION FOR AUTOMATIC DETECTION OF BRAIN TUMORS IN MRI A.S. Capelle, O. Alata, C- thod for magnetic resonance images. The aim of this seg- mentation is to divide the brain

  18. XRDS summer 2010 Vol .16 No.442 From Brains

    E-Print Network [OSTI]

    Jacob, Robert J.K.

    XRDS · summer 2010 · Vol .16 · No.442 From Brains to Bytes Although most people are likely all-powerful, BCI research. In the past year, University of Wisconsin-Madison's Brain-Twitter in- terface received Time Magazine's honor as the no. 9 invention of the year. Fur- thermore, as brain

  19. Intra-operative Registration for Deep Brain Stimulation Procedures

    E-Print Network [OSTI]

    Boyer, Edmond

    Intra-operative Registration for Deep Brain Stimulation Procedures based on a Full Physics Head´e Rennes I Abstract. Brain deformation is a factor of inaccuracy during stereo- tactic neurosurgeries to update the pre-operative planning based on a physical simulation of the brain shift. A minimization

  20. ORIGINAL ARTICLE Early Brain Overgrowth in Autism Associated

    E-Print Network [OSTI]

    Utah, University of

    ORIGINAL ARTICLE Early Brain Overgrowth in Autism Associated With an Increase in Cortical Surface, PhD; Chad Chappell, MA; Rachel Gimpel Smith, BA; Clement Vachet, MS; Joseph Piven, MD Context: Brain. Objective: To investigate early growth trajectories in brain volume and cortical thickness. Design

  1. Development of an Interhemispheric Symmetry Measurement in the Neonatal Brain

    E-Print Network [OSTI]

    Development of an Interhemispheric Symmetry Measurement in the Neonatal Brain Ninah Koolen1.dereymaeker, katrien.jansen, jan.vervisch, gunnar.naulaers}@uzleuven.be Keywords: Preterm Brain, Symmetry, Channel of different brain regions will allow detecting physiologic asymmetry versus pathologic asymmetry. This can

  2. adult rodent brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adult rodent brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 RODENT BRAIN NAVIGATOR :RODENT BRAIN...

  3. POSTER PRESENTATION Open Access Spatiotemporal dynamics in the human brain

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    POSTER PRESENTATION Open Access Spatiotemporal dynamics in the human brain during rest: a virtual brain study Andreas Spiegler* , Enrique Hansen, Viktor K Jirsa From Twenty Second Annual Computational Neuroscience Meeting: CNS*2013 Paris, France. 13-18 July 2013 Over the past years the ongoing human brain

  4. Brain (1999), 122, 839854 Electrophysiological manifestations of open-and

    E-Print Network [OSTI]

    Coulson, Seana

    Brain (1999), 122, 839­854 Electrophysiological manifestations of open- and closed-class words in patients with Broca's aphasia with agrammatic comprehension An event-related brain potential study Mariken-related brain potentials were recorded from the scalp when Broca patients and non- aphasic control subjects were

  5. Probing the brain’s white matter with diffusion MRI and a tissue dependent diffusion model 

    E-Print Network [OSTI]

    Piatkowski, Jakub Przemyslaw

    2014-06-27T23:59:59.000Z

    While diffusion MRI promises an insight into white matter microstructure in vivo, the axonal pathways that connect different brain regions together can only partially be segmented using current methods. Here we present ...

  6. ANNUAL REPORT National Brain Research Centre

    E-Print Network [OSTI]

    Dhingra, Narender K.

    1 ANNUAL REPORT 2003-2004 National Brain Research Centre Manesar, India #12;2 Table of Contents in neuroscience. Promoting neuroscience in India through networking among institutions across the country. If we can fathom how children learn, our education policy could be strengthened with a new understanding

  7. Possible new wave phenomena in the brain

    E-Print Network [OSTI]

    Jerzy Szwed

    2009-08-10T23:59:59.000Z

    We propose to search for new wave phenomena in the brain by using interference effects in analogy to the well-known double slit (Young) experiment. This method is able to extend the range of oscillation frequencies to much higher values than currently accessible. It is argued that such experiments may test the hypothesis of the wave nature of information coding.

  8. Research Article Human Brain Activity Time-

    E-Print Network [OSTI]

    Zacks, Jeffrey M.

    Research Article Human Brain Activity Time- Locked to Narrative Event Boundaries Nicole K. Speer to or reading descriptions of everyday activities (e.g., reading about a person making cookies; Speer & Zacks, 2005; Speer, Zacks, & Reynolds, 2006). These findings are not altogether surprising given theories

  9. Bruce Braine VP, Strategic Policy Analysis

    E-Print Network [OSTI]

    Howat, Ian M.

    5/16/2014 1 Bruce Braine VP, Strategic Policy Analysis American Electric Power Thursday, May 15, 2014 Power Infrastructure: Improving Reliability and Resiliency 2 · 5.3 Million customers · 11 States regulations. 4 #12;5/16/2014 3 Power Infrastructure · Ongoing threats to power infrastructure and reliability

  10. Experimental Brain Research ISSN 0014-4819

    E-Print Network [OSTI]

    Rosen, Jacob

    of speeds Matt Simkins, Anne Burleigh Jacobs & Jacob Rosen #12;1 3 Exp Brain Res (2013) 229:517­524 DOI 10 of speeds Matt Simkins · Anne Burleigh Jacobs · Jacob Rosen Received: 1 April 2013 / Accepted: 9 June 2013 motion. M. Simkins (*) · J. Rosen Department of Computer Engineering, University of California, Santa

  11. Abstract -Other researchers have proposed that the brain parenchymal fraction (or brain atrophy) may be a good surrogate

    E-Print Network [OSTI]

    Orchard, Jeffery J.

    head MRI scans. An automatic segmentation method for the brain and for the cerebral spinal fluid measure of brain atrophy automatically from head MRI scans acquired as 5mm thick axial slices. We were from the head in MRI scans [5]. The brain mask is obtained by anisotropic diffusion of the T2 image

  12. In: Proceedings of SPIE Conference on Medical Imaging (4684), pp. 201-205, Feb. 2002. Robustness of the Brain Parenchymal Fraction for Measuring Brain

    E-Print Network [OSTI]

    Orchard, Jeffery J.

    -echo PD and T2-weighted head MRI scans. The robustness of the brain parenchymal fraction is evaluated of the Brain Parenchymal Fraction for Measuring Brain Atrophy M. Stella Atkins, Jeff J. Orchard, Ben Law ABSTRACT Other researchers have proposed that the brain parenchymal fraction (or brain atrophy) may

  13. 1/12/11 1:51 PMComputer-Aided Brains: Scientific American Page 1 of 3http://www.scientificamerican.com/article.cfm?id=computer-aided-brains

    E-Print Network [OSTI]

    Salvucci, Dario D.

    » Scientific American Mind » October 2005 Head Lines | Mind & Brain Computer-Aided Brains By Brad Stenger1/12/11 1:51 PMComputer-Aided Brains: Scientific American Page 1 of 3http://www.scientificamerican.com/article.cfm?id=computer-aided-brains Image: For years, innovators have tried to devise computerized gadgetry to aid the brain. Advances have

  14. ScaleScale--free Brain Functional Networksfree Brain Functional Networks victor@imedea.uib.es www.imedea.uib.es/~victor

    E-Print Network [OSTI]

    Oro, Daniel

    ScaleScale--free Brain Functional Networksfree Brain Functional Networks victor@imedea.uib.es wwwPlan Motivation: Networks & Brain How to get functional networks from fMRI Characterization of brain functional) Co-authorship of scientific papers #12;...... and the brainand the brain #12;""In catalogue" cortical

  15. Role of Family Satisfaction in Predicting Life Satisfaction Trajectories Over the First Five Years Following Acquired Disability

    E-Print Network [OSTI]

    Herna?ndez, Caitlin Louise

    2012-10-19T23:59:59.000Z

    INTRODUCTION: THE IMPORTANCE OF RESEARCH Incidence of Traumatic Injuries Traumatic injury impacts thousands of people each year, altering the course of their lives and the lives of their families physically, emotionally, socially, and economically.... The National Spinal Cord Injury Statistical Center (2008) estimates that approximately 12,000 people sustain a Spinal Cord Injury (SCI) each year in the United States, with over 200,000 people currently living with an SCI. The number of traumatic injuries...

  16. Radiation-induced esophageal injury: A spectrum from esophagitis to cancer

    SciTech Connect (OSTI)

    Vanagunas, A.; Jacob, P.; Olinger, E. (Northwestern Univ. Medical School, Chicago, IL (USA))

    1990-07-01T23:59:59.000Z

    Radiation esophagitis is a common but frequently unrecognized complication of therapeutic radiation to the neck, chest, or mediastinum. The spectrum of injury ranges from acute self-limited esophagitis to life-threatening esophageal perforation. Complications such as stricture or primary esophageal cancer may occur many years after irradiation, and their linkage to radiation may not be considered. Five cases of radiation-induced injury are described, and the spectrum of radiation-induced esophageal injury is reviewed.

  17. 2003 Oak Ridge National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-05-23T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for ORNL. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  18. 2003 Idaho National Engineering and Environmental Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-05-23T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for Idaho National Lab. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  19. 2006 Los Alamos National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-06-13T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  20. 2006 Oak Ridge National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-05-16T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  1. 2007 East Tennessee Technology Park Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2009-07-13T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  2. 2010 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-08-31T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  3. 2006 Lawrence Livermore National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-03-27T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  4. 2004 Hanford Site Annual Illness and Injury Surveillance Report, Revised October 2007

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-10-24T23:59:59.000Z

    Annual Illness and Injury Surveillance Program for 2004 for the Hanford site. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  5. 2007 Lawrence Livermore National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-05-20T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  6. 2010 East Tennessee Technology Park Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-08-16T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  7. 2010 Oak Ridge National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-07-28T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  8. 2006 Sandia National Laboratories--Albuquerque Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-05-13T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  9. 2006 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2008-04-17T23:59:59.000Z

    The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  10. 2010 Nevada National Security Site Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-07-28T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  11. 2010 Lawrence Livermore National Laboratory Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Health, Office of Health and Safety, Office of Illness and Injury Prevention Programs

    2011-08-16T23:59:59.000Z

    The U.S. Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of illness and injury surveillance activities that provide an early warning system to detect health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence, occupational injuries and illnesses, and disabilities and deaths among current workers.

  12. AMP kinase attenuates biomechanical injury induced endoplasmic reticulum stress and catabolic responses in articular chondrocytes

    E-Print Network [OSTI]

    Petursson, Freyr

    2012-01-01T23:59:59.000Z

    2: Custom Made Bioreactor…………………………………………….. 38 Figure 3:times post injury. Figure 2. Custom Made Bioreactor Custommade bioreactor is housed inside a 37°C incubator maintained

  13. E-Print Network 3.0 - acute liver injury Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: NKT-deficient mice are more susceptible to carbon...

  14. Yield and Clinical Predictors of Thoracic Spine Injury from Chest Computed Tomography for Blunt Trauma

    E-Print Network [OSTI]

    2014-01-01T23:59:59.000Z

    Injury from Chest Computed Tomography for Blunt Trauma Markthe use of chest computed tomography (CT), (CCT) in bluntinjury. 6,7 Chest computed tomography (CCT) evaluation for

  15. Plasma Proteome Response to Severe Burn Injury Revealed by 18O...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    worldwide. Here, we present the first quantitative proteomics investigation of the blood plasma proteome response to severe burn injury by comparing the plasma protein...

  16. Thermoacoustic tomography arising in brain imaging

    E-Print Network [OSTI]

    Stefanov, Plamen

    2010-01-01T23:59:59.000Z

    We study the mathematical model of thermoacoustic and photoacoustic tomography when the sound speed has a jump across a smooth surface. This models the change of the sound speed in the skull when trying to image the human brain. We derive an explicit inversion formula in the form of a convergent Neumann series under the assumptions that all singularities from the support of the source reach the boundary.

  17. Thermoacoustic tomography arising in brain imaging

    E-Print Network [OSTI]

    Plamen Stefanov; Gunther Uhlmann

    2010-09-09T23:59:59.000Z

    We study the mathematical model of thermoacoustic and photoacoustic tomography when the sound speed has a jump across a smooth surface. This models the change of the sound speed in the skull when trying to image the human brain. We derive an explicit inversion formula in the form of a convergent Neumann series under the assumptions that all singularities from the support of the source reach the boundary.

  18. Brain-Computer Interfaces and Quantum Robots

    E-Print Network [OSTI]

    Eliano Pessa; Paola zizzi

    2009-09-08T23:59:59.000Z

    The actual (classical) Brain-Computer Interface attempts to use brain signals to drive suitable actuators performing the actions corresponding to subject's intention. However this goal is not fully reached, and when BCI works, it does only in particular situations. The reason of this unsatisfactory result is that intention cannot be conceived simply as a set of classical input-output relationships. It is therefore necessary to resort to quantum theory, allowing the occurrence of stable coherence phenomena, in turn underlying high-level mental processes such as intentions and strategies. More precisely, within the context of a dissipative Quantum Field Theory of brain operation it is possible to introduce generalized coherent states associated, within the framework of logic, to the assertions of a quantum metalanguage. The latter controls the quantum-mechanical computing corresponding to standard mental operation. It thus become possible to conceive a Quantum Cyborg in which a human mind controls, through a quantum metalanguage, the operation of an artificial quantum computer.

  19. PIA - Richland Occupational Injury and Illness | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613 122Commercial602 1,39732onMakeEducation Programs Business EnclavePositive PayInjury and

  20. Injury and Illness Reporting Guide | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking of BlytheDepartment ofEnergy Information forInjury and Illness Reporting

  1. Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients

    SciTech Connect (OSTI)

    Rades, Dirk, E-mail: rades.dirk@gmx.net [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Lubeck (Germany); Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg (Germany); Evers, Jasmin N. [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Lubeck (Germany); Veninga, Theo [Department of Radiotherapy, Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Stalpers, Lukas J.A. [Department of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands); Lohynska, Radka [Department of Radiation Oncology, University Hospital, Prague (Czech Republic); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic Scottsdale, Arizona (United States)

    2011-11-15T23:59:59.000Z

    Purpose: Many patients with brain metastases receive whole-brain radiotherapy (WBRT) alone. Using 10 Multiplication-Sign 3 Gy in 2 weeks is the standard regimen in most centers. Regarding the extraordinarily poor survival prognosis of elderly patients with multiple brain metastases, a shorter WBRT regimen would be preferable. This study compared 10 Multiplication-Sign 3 Gy with 5 Multiplication-Sign 4 Gy in elderly patients ({>=}65 years). Methods and Materials: Data from 455 elderly patients who received WBRT alone for brain metastases were retrospectively analyzed. Survival and local (= intracerebral) control of 293 patients receiving 10 Multiplication-Sign 3 Gy were compared with 162 patients receiving 5 Multiplication-Sign 4 Gy. Eight additional potential prognostic factors were investigated including age, gender, Karnofsky performance score (KPS), primary tumor, number of brain metastases, interval from tumor diagnosis to WBRT, extracerebral metastases, and recursive partitioning analysis (RPA) class. Results: The 6-month overall survival rates were 29% after 5 Multiplication-Sign 4 Gy and 21% after 10 Multiplication-Sign 3 Gy (p = 0.020). The 6-month local control rates were 12% and 10%, respectively (p = 0.32). On multivariate analysis, improved overall survival was associated with KPS {>=} 70 (p < 0.001), only one to three brain metastases (p = 0.029), no extracerebral metastasis (p = 0.012), and lower RPA class (p < 0.001). Improved local control was associated with KPS {>=} 70 (p < 0.001), breast cancer (p = 0.029), and lower RPA class (p < 0.001). Conclusions: Shorter-course WBRT with 5 Multiplication-Sign 4 Gy was not inferior to 10 Multiplication-Sign 3 Gy with respect to overall survival or local control in elderly patients. 5 Multiplication-Sign 4 Gy appears preferable for the majority of these patients.

  2. The new trend in back injury prevention programs

    SciTech Connect (OSTI)

    Rummerfield, P.D.

    1996-12-31T23:59:59.000Z

    The reduction in Worker`s Compensation costs through lumbar strengthening programs is now a proven approach. This is the beginning of a new era in injury prevention. Imagine a test for muscle imbalance along with the strength of all the major muscle groups of every person on the mine site. Occupations, such as roof bolters, and operators of haul trucks, dozers, scrapers, continuous miners and shuttle cars could be tested for musculoskeletal strength of the spine and extremities. With this test data you could then compare your findings to the strength norms necessary for that person to perform his/her job task safely. Armed with this information, you could drastically reduce Workers` Compensation costs due to strains and sprains. Earl Hoerner, M.D. and Robert Wainwright, P.T. have consolidated these cutting-edge technologies that will produce the benchmark for industrial injury prevention for the next century. These technologies are available today, waiting to be used in an industrial setting by a management team with vision.

  3. Most Workers Who Suffer Head Injuries- Were Not Wearing Head Protection

    Broader source: Energy.gov [DOE]

    A survey by the U.S. Department of Labor’s Bureau of Labor Statistics (BLS) of accidents and injuries noted that most workers who suffered impact injuries to the head were not wearing head protection. In addition, the same survey showed that the majority of workers were injured while performing their normal jobs at their regular worksites.

  4. A systematic review of clinical decision rules in the management of adult minor head injury

    E-Print Network [OSTI]

    Oakley, Jeremy

    is the diagnostic standard for identifying intracranial injury. Routine CT of all minor head injury patients would or APi). Twenty-two articles, representing nineteen studies, were identified. The median prevalence.5%). Patient selection, use of reference standards and outcome definitions all varied. These variations

  5. Off-the-Job Injuries are on the Rise- and Costly

    Broader source: Energy.gov [DOE]

    Do you have an off-the-job safety program? Should you? The findings from a National Safety Council survey suggest that off-the-job injuries cost companies and society in general as much, if not more than on-the-job injuries!

  6. RESEARCH FOUNDATION -STATE UNIVERSITY OF NEW YORK REPORT OF ACCIDENT OR INJURY

    E-Print Network [OSTI]

    Suzuki, Masatsugu

    RESEARCH FOUNDATION - STATE UNIVERSITY OF NEW YORK REPORT OF ACCIDENT OR INJURY (OTHER THAN A MOTOR VEHICLE ACCIDENT) Revised: July 2008 1. Date and T ime of accident: Date: T ime: 2. Date of Report: 3. T o be completed by Safety Supervisor: YEAR: NO.: SEQUENCE: FILE ID: 4. Did accident involve personal injury? Yes

  7. Gamma Knife Radiosurgery for Brain Metastases From Primary Breast Cancer

    SciTech Connect (OSTI)

    Kased, Norbert, E-mail: Norbert.Kased@ucsf.ed [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Binder, Devin K. [Department of Neurological Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); McDermott, Michael W. [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Department of Neurological Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Nakamura, Jean L.; Huang, Kim [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Berger, Mitchel S. [Department of Neurological Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA (United States); Wara, William M.; Sneed, Penny K. [Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA (United States)

    2009-11-15T23:59:59.000Z

    Purpose: The relative roles of stereotactic radiosurgery (SRS) vs. whole brain radiotherapy (WBRT) in the treatment of patients with brain metastases from breast cancer remain undefined. In this study, we reviewed our experience with these patients. Materials and Methods: We retrospectively reviewed all patients treated between 1991 and 2005 with Gamma Knife SRS for brain metastases from breast cancer. The actuarial survival and freedom from progression endpoints were calculated using the Kaplan-Meier method. Results: Between 1991 and 2005, 176 patients underwent SRS for brain metastases from breast cancer. The median survival time was 16.0 months for 95 newly diagnosed patients and 11.7 months for 81 patients with recurrent brain metastases. In the newly diagnosed patients, omission of upfront WBRT did not significantly affect the MST (p = .20), brain freedom from progression (p = .75), or freedom from new brain metastases (p = .83). Longer survival was associated with age <50 years, Karnofsky performance score >=70, primary tumor control, estrogen receptor positivity, and Her2/neu overexpression. No association was found between the number of treated brain metastases and the survival time. Conclusion: We have described prognostic factors for breast cancer patients treated with SRS for newly diagnosed or recurrent brain metastases. Most patient subsets had a median survival time of >=11 months. Unexpectedly, upfront WBRT did not appear to improve brain freedom from progression, and a larger number of brain metastases was not associated with a shorter survival time. Breast cancer might be distinct from other primary sites in terms of prognostic factors and the roles of WBRT and SRS for brain metastases.

  8. Ergonomics and Musculoskeletal Injuries in Agriculture: Recognizing and Preventing the Industry's Most Widespread Health and Safety Problem

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    Ergonomics and Musculoskeletal Injuries in Agriculture: Recognizing and Preventing the Industry demonstrated that these potentially permanently disabling injuries are readily prevented using ergonomics that agricultural work is diverse and so agricultural ergonomics must bridge many specific problems with a flexible

  9. Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury

    E-Print Network [OSTI]

    Raczynski, Arkadiusz R. (Arkadiusz Roland)

    2011-01-01T23:59:59.000Z

    The activation of inflammatory responses, while critical for host defense, contributes to hepatic injury in numerous acute and chronic liver disease states as well as drug-induced liver injury (DILI). The interactions that ...

  10. FireStem2D A Two-Dimensional Heat Transfer Model for Simulating Tree Stem Injury in Fires

    E-Print Network [OSTI]

    FireStem2D ­ A Two-Dimensional Heat Transfer Model for Simulating Tree Stem Injury in Fires, et al. (2013) FireStem2D ­ A Two-Dimensional Heat Transfer Model for Simulating Tree Stem Injury

  11. Study of the brain connectivity in an Immersive Space Anne-Charlotte Philippe

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Study of the brain connectivity in an Immersive Space Anne-Charlotte Philippe ATHENA/INRIA Sophia of the brain connectivity. Both anatomical and functional data are attached to a mesh representing the brain the experience of the visualization of brain meshes in an immersive space for the specific study of brain con

  12. Automatic Scan Prescription for Brain MRI T. Ernst, L. Itti, L. Chang

    E-Print Network [OSTI]

    Itti, Laurent

    Automatic Scan Prescription for Brain MRI T. Ernst, L. Itti, L. Chang Harbor-UCLA Medical Center that allows the automatic prescription of brain MRI scans. This involves determination of the orientation of the current patient's brain, by matching his/her brain surface with a template brain surface. A desired

  13. Behavioural Brain Research 179 (2007) 281293 Research report

    E-Print Network [OSTI]

    Grau, James

    2007-01-01T23:59:59.000Z

    . These data imply that nociceptive input (e.g., from tissue damage) can enhance the loss of function after injury, and that potential clinical treatments, such as pretreatment with an analgesic, may protect

  14. Chaotic physics in ferroelectrics hints at brain-like computing...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Oak Ridge National Laboratory 865-574-7308 Chaotic physics in ferroelectrics hints at brain-like computing Unexpected behavior in ferroelectric materials explored by researchers...

  15. Complex Networks - A Key to Understanding Brain Function

    SciTech Connect (OSTI)

    Olaf Sporns

    2008-01-23T23:59:59.000Z

    The brain is a complex network of neurons, engaging in spontaneous and evoked activity that is thought to be the main substrate of mental life.  How this complex system works together to process information and generate coherent cognitive states, even consciousness, is not yet well understood.  In my talk I will review recent studies that have revealed characteristic structural and functional attributes of brain networks, and discuss efforts to build computational models of the brain that are informed by our growing knowledge of brain anatomy and physiology.

  16. Algorithms for enhanced spatiotemporal imaging of human brain function

    E-Print Network [OSTI]

    Krishnaswamy, Pavitra

    2014-01-01T23:59:59.000Z

    Studies of human brain function require technologies to non-invasively image neuronal dynamics with high spatiotemporal resolution. The electroencephalogram (EEG) and magnetoencephalogram (MEG) measure neuronal activity ...

  17. Complex Networks - A Key to Understanding Brain Function

    ScienceCinema (OSTI)

    Olaf Sporns

    2010-01-08T23:59:59.000Z

    The brain is a complex network of neurons, engaging in spontaneous and evoked activity that is thought to be the main substrate of mental life.  How this complex system works together to process information and generate coherent cognitive states, even consciousness, is not yet well understood.  In my talk I will review recent studies that have revealed characteristic structural and functional attributes of brain networks, and discuss efforts to build computational models of the brain that are informed by our growing knowledge of brain anatomy and physiology.

  18. abnormal brain glucose: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain...

  19. abnormal brain morphology: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain...

  20. abnormal brain processing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain...

  1. abnormal brain iron: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain...

  2. abnormal brain ct: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain...

  3. abnormal brain connection: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain...

  4. Whole Brain Irradiation With Hippocampal Sparing and Dose Escalation on Multiple Brain Metastases: A Planning Study on Treatment Concepts

    SciTech Connect (OSTI)

    Prokic, Vesna, E-mail: vesna.prokic@uniklinik-freiburg.de [Department of Radiation Oncology, University Medical Center Freiburg, Freiburg (Germany)] [Department of Radiation Oncology, University Medical Center Freiburg, Freiburg (Germany); Wiedenmann, Nicole; Fels, Franziska; Schmucker, Marianne [Department of Radiation Oncology, University Medical Center Freiburg, Freiburg (Germany)] [Department of Radiation Oncology, University Medical Center Freiburg, Freiburg (Germany); Nieder, Carsten [Department of Oncology and Palliative Medicine, Nordland Hospital, Bodo (Norway) [Department of Oncology and Palliative Medicine, Nordland Hospital, Bodo (Norway); Institute of Clinical Medicine, Faculty of Health Sciences, University of Tromso, Tromso (Norway); Grosu, Anca-Ligia [Department of Radiation Oncology, University Medical Center Freiburg, Freiburg (Germany)] [Department of Radiation Oncology, University Medical Center Freiburg, Freiburg (Germany)

    2013-01-01T23:59:59.000Z

    Purpose: To develop a new treatment planning strategy in patients with multiple brain metastases. The goal was to perform whole brain irradiation (WBI) with hippocampal sparing and dose escalation on multiple brain metastases. Two treatment concepts were investigated: simultaneously integrated boost (SIB) and WBI followed by stereotactic fractionated radiation therapy sequential concept (SC). Methods and Materials: Treatment plans for both concepts were calculated for 10 patients with 2-8 brain metastases using volumetric modulated arc therapy. In the SIB concept, the prescribed dose was 30 Gy in 12 fractions to the whole brain and 51 Gy in 12 fractions to individual brain metastases. In the SC concept, the prescription was 30 Gy in 12 fractions to the whole brain followed by 18 Gy in 2 fractions to brain metastases. All plans were optimized for dose coverage of whole brain and lesions, simultaneously minimizing dose to the hippocampus. The treatment plans were evaluated on target coverage, homogeneity, and minimal dose to the hippocampus and organs at risk. Results: The SIB concept enabled more successful sparing of the hippocampus; the mean dose to the hippocampus was 7.55 {+-} 0.62 Gy and 6.29 {+-} 0.62 Gy, respectively, when 5-mm and 10-mm avoidance regions around the hippocampus were used, normalized to 2-Gy fractions. In the SC concept, the mean dose to hippocampus was 9.8 {+-} 1.75 Gy. The mean dose to the whole brain (excluding metastases) was 33.2 {+-} 0.7 Gy and 32.7 {+-} 0.96 Gy, respectively, in the SIB concept, for 5-mm and 10-mm hippocampus avoidance regions, and 37.23 {+-} 1.42 Gy in SC. Conclusions: Both concepts, SIB and SC, were able to achieve adequate whole brain coverage and radiosurgery-equivalent dose distributions to individual brain metastases. The SIB technique achieved better sparing of the hippocampus, especially when a10-mm hippocampal avoidance region was used.

  5. Regulation of brain copper homeostasis by the brain barrier systems: Effects of Fe-overload and Fe-deficiency

    SciTech Connect (OSTI)

    Monnot, Andrew D.; Behl, Mamta; Ho, Sanna; Zheng, Wei, E-mail: wzheng@purdue.edu

    2011-11-15T23:59:59.000Z

    Maintaining brain Cu homeostasis is vital for normal brain function. The role of systemic Fe deficiency (FeD) or overload (FeO) due to metabolic diseases or environmental insults in Cu homeostasis in the cerebrospinal fluid (CSF) and brain tissues remains unknown. This study was designed to investigate how blood-brain barrier (BBB) and blood-SCF barrier (BCB) regulated Cu transport and how FeO or FeD altered brain Cu homeostasis. Rats received an Fe-enriched or Fe-depleted diet for 4 weeks. FeD and FeO treatment resulted in a significant increase (+ 55%) and decrease (- 56%) in CSF Cu levels (p < 0.05), respectively; however, neither treatment had any effect on CSF Fe levels. The FeD, but not FeO, led to significant increases in Cu levels in brain parenchyma and the choroid plexus. In situ brain perfusion studies demonstrated that the rate of Cu transport into the brain parenchyma was significantly faster in FeD rats (+ 92%) and significantly slower (- 53%) in FeO rats than in controls. In vitro two chamber Transwell transepithelial transport studies using primary choroidal epithelial cells revealed a predominant efflux of Cu from the CSF to blood compartment by the BCB. Further ventriculo-cisternal perfusion studies showed that Cu clearance by the choroid plexus in FeD animals was significantly greater than control (p < 0.05). Taken together, our results demonstrate that both the BBB and BCB contribute to maintain a stable Cu homeostasis in the brain and CSF. Cu appears to enter the brain primarily via the BBB and is subsequently removed from the CSF by the BCB. FeD has a more profound effect on brain Cu levels than FeO. FeD increases Cu transport at the brain barriers and prompts Cu overload in the CNS. The BCB plays a key role in removing the excess Cu from the CSF.

  6. Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries

    SciTech Connect (OSTI)

    Tewari-Singh, Neera, E-mail: Neera.Tewari-Singh@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States)] [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Jain, Anil K., E-mail: Anil.Jain@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Inturi, Swetha, E-mail: Swetha.Inturi@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States)] [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Ammar, David A., E-mail: David.Ammar@ucdenver.edu [Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Agarwal, Chapla, E-mail: Chapla.Agarwal@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States)] [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Tyagi, Puneet, E-mail: Puneet.Tyagi@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States)] [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Kompella, Uday B., E-mail: Uday.Kompella@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Enzenauer, Robert W., E-mail: Robert.Enzenauer@ucdenver.edu [Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Petrash, J. Mark, E-mail: Mark.Petrash@ucdenver.edu [Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Agarwal, Rajesh, E-mail: Rajesh.Agarwal@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States)] [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States)

    2012-10-01T23:59:59.000Z

    There are no effective and approved therapies against devastating ocular injuries caused by vesicating chemical agents sulfur mustard (SM) and nitrogen mustard (NM). Herein, studies were carried out in rabbit corneal cultures to establish relevant ocular injury biomarkers with NM for screening potential efficacious agents in laboratory settings. NM (100 nmol) exposure of the corneas for 2 h (cultured for 24 h), showed increases in epithelial thickness, ulceration, apoptotic cell death, epithelial detachment microbullae formation, and the levels of VEGF, cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9). Employing these biomarkers, efficacy studies were performed with agent treatments 2 h and every 4 h thereafter, for 24 h following NM exposure. Three agents were evaluated, including prescription drugs dexamethasone (0.1%; anti-inflammatory steroid) and doxycycline (100 nmol; antibiotic and MMP inhibitor) that have been studied earlier for treating vesicant-induced eye injuries. We also examined silibinin (100 ?g), a non-toxic natural flavanone found to be effective in treating SM analog-induced skin injuries in our earlier studies. Treatments of doxycycline + dexamethasone, and silibinin were more effective than doxycycline or dexamethasone alone in reversing NM-induced epithelial thickening, microbullae formation, apoptotic cell death, and MMP-9 elevation. However, dexamethasone and silibinin alone were more effective in reversing NM-induced VEGF levels. Doxycycline, dexamethasone and silibinin were all effective in reversing NM-induced COX-2 levels. Apart from therapeutic efficacy of doxycycline and dexamethasone, these results show strong multifunctional efficacy of silibinin in reversing NM-induced ocular injuries, which could help develop effective and safe therapeutics against ocular injuries by vesicants. -- Highlights: ? Established injury biomarkers in rabbit corneal culture with nitrogen mustard (NM) ? This NM model is a cost effective system to evaluate and optimize therapeutics. ? Show that doxycycline and dexamethasone reduce NM-caused ocular injuries ? Demonstrate that silibinin effectively reverses NM-caused ocular injury endpoints ? Suggest optimization of identified agents against ocular injuries by vesicants.

  7. Quantum features of consciousness, computers and brain

    E-Print Network [OSTI]

    Michael B. Mensky

    2009-10-22T23:59:59.000Z

    Many people believe that mysterious phenomenon of consciousness may be connected with quantum features of our world. The present author proposed so-called Extended Everett's Concept (EEC) that allowed to explain consciousness and super-consciousness (intuitive knowledge). Brain, according to EEC, is an interface between consciousness and super-consciousness on the one part and body on the other part. Relations between all these components of the human cognitive system are analyzed in the framework of EEC. It is concluded that technical devices improving usage of super-consciousness (intuition) may exist.

  8. Solar Brain Srl | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt LtdShawangunk, New York:SiG26588°,SocorromercurySolaire DirectBrain Srl Jump

  9. Visualizing Brain Metals in Health and Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrincetonUsing Maps1 -Visualizing Brain Metals in Health and Disease

  10. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced Materials Find FindRewindParticleBorncelebrates itsBradyBrain

  11. Brain Receptor Structures Key to Future Therapeutics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting the TWPSuccess Stories Site MapSolarAboutTaubman BradburyBradleyBrain

  12. Seasonal development of ozone-induced foliar injury on tall milkweed (Asclepias exaltata) in Great Smoky Mountains National Park

    E-Print Network [OSTI]

    Neufeld, Howard S.

    Seasonal development of ozone-induced foliar injury on tall milkweed (Asclepias exaltata) in Great by symptoms of foliar ozone injury. Abstract The goals of this study were to document the development of ozone-induced foliar injury, on a leaf-by-leaf basis, and to develop ozone exposure relationships for leaf cohorts

  13. Incidence of Leukoencephalopathy After Whole-Brain Radiation Therapy for Brain Metastases

    SciTech Connect (OSTI)

    Ebi, Junko, E-mail: junkoe@fmu.ac.jp [Department of Radiology, Fukushima Medical University, Fukushima (Japan)] [Department of Radiology, Fukushima Medical University, Fukushima (Japan); Sato, Hisashi; Nakajima, Masaru; Shishido, Fumio [Department of Radiology, Fukushima Medical University, Fukushima (Japan)] [Department of Radiology, Fukushima Medical University, Fukushima (Japan)

    2013-04-01T23:59:59.000Z

    Purpose: To evaluate the incidence of leukoencephalopathy after whole-brain radiation therapy (WBRT) in patients with brain metastases. Methods and Materials: We retrospectively reviewed 111 patients who underwent WBRT for brain metastases from April 2001 through March 2008 and had evaluable computed tomography (CT) and/or magnetic resonance imaging (MRI) at least 1 month after completion of WBRT. We evaluated the leukoencephalopathy according to the Common Terminology Criteria for Adverse Events, version 3.0. The patients who had brain tumor recurrence after WBRT were censored at the last follow-up CT or MRI without recurrence. To evaluate the risk factors for leukoencephalopathy, bivariate analysis was performed using a logistic regression analysis adjusted for follow-up time. Factors included in the analysis were age, gender, dose fractionation, 5-fluorouracil, methotrexate, cisplatin, and other chemotherapeutic agents. Results: The median age of the 111 patients was 60.0 years (range, 23-89 years). The median follow-up was 3.8 months (range, 1.0-38.1 months). Leukoencephalopathy developed in 23 of the 111 patients. Grades 1, 2, and 3 were observed in 8, 7, and 8 patients, respectively. The incidence was 34.4% (11 of 32), 42.9% (6 of 14), 66.7% (2 of 3), and 100% (2 of 2) of the patients who were followed up for ?6, ?12, ?24, and ?36 months, respectively. In the bivariate analysis, older age (?65 years) was significantly correlated with higher risk of leukoencephalopathy (odds ratio 3.31; 95% confidence interval 1.15-9.50; P=.03). Conclusions: The incidence of leukoencephalopathy after WBRT was 34.4% with ?6 months follow-up, and increased with longer follow-up. Older age was a significant risk factor. The schedule of WBRT for patients with brain metastases should be carefully determined, especially for favorable patients.

  14. Right Brain/Left Brain Dominance Are you a global thinker or an analytical thinker? Identify which of the following traits you

    E-Print Network [OSTI]

    Westfall, Peter H.

    1 Right Brain/Left Brain Dominance Are you a global thinker or an analytical thinker? Identify track of your answers. Right Brain Dominant __ When given a task or assignment, you want to know why it if you mean to be. Left Brain Dominant __ When given a task or assignment, you don't always need to know

  15. Train Your Brain Math Club Train Your Brain Math Club meets on Fridays at 4:20-5:20pm. The aim is to teach high

    E-Print Network [OSTI]

    Blokh, Alexander

    Train Your Brain Math Club Train Your Brain Math Club meets on Fridays at 4:20-5:20pm. The aim in joining Train Your Brain Math Club should call UAB Special Studies at (205)934-8263 and mention Train Your Brain Math Club. Contact information: Dr A. Blokh, Coordinator of Outreach Program Department

  16. Brain-computer interface controlled functional electrical stimulation system for ankle movement.

    E-Print Network [OSTI]

    Do, An H; Wang, Po T; King, Christine E; Abiri, Ahmad; Nenadic, Zoran

    2011-01-01T23:59:59.000Z

    N: Breaking the silence: Brain-computer interfaces (BCI) forsignal by a noninvasive brain-computer interface in humans.E: A novel P300-based brain- computer interface stimulus

  17. Brain covariance selection: better individual functional connectivity models using population prior

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Brain covariance selection: better individual functional connectivity models using population prior bertrand.thirion@inria.fr Abstract Spontaneous brain activity, as observed in functional neuroimaging, has been shown to display reproducible structure that expresses brain architecture and car- ries markers

  18. Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    SJ, Horton RW (1988) Brain GABAA/benzodiazepine bindingin depressed suicide victims. Brain Res 460: 114–123. 18.labelled with [3H]MK-801, in brain samples from drug-free

  19. Memory, brain and aging: The good, the bad and the promising

    E-Print Network [OSTI]

    Ober, Beth A.

    2010-01-01T23:59:59.000Z

    in the healthy aging brain. Neu- ropsychology 23(5):541–50.Development in the Adult Brain. New York, NY: Oxford Univinfluences on cognitive and brain plasticity during aging. J

  20. How Does the Brain Learn to Read? Guest Lecture by James R. Booth

    E-Print Network [OSTI]

    Loudon, Catherine

    How Does the Brain Learn to Read? Guest Lecture by James R that general principles of brain development are key to reaching a deeper understanding) the specialization of brain regions for different computations and (2) the interaction between

  1. The Brain, Seizures and Epilepsy Throughout Life: Understanding a Moving Target

    E-Print Network [OSTI]

    Baram, Tallie Z.

    2012-01-01T23:59:59.000Z

    SL. Why is the developing brain more susceptible to statusand relationship to epilepsy. Brain Dev 2009;31:366–371. 46.child, adult, and aging brain is crucial for optimal

  2. Nonlinear brain dynamics as macroscopic manifestation of underlying many-body field dynamics

    E-Print Network [OSTI]

    Freeman, Walter J III; Vitiello, G

    2006-01-01T23:59:59.000Z

    and should be done next. Brain dynamics and many-body fielddissipative quantum model of brain. Int J Mod Phys B14: 853-Neurotransmission and Late Brain Reorganization. New York:

  3. Growth hormone responsive neural precursor cells reside within the adult mammalian brain

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    within the adult mammalian brain. Sci. Rep. 2, 250; DOI:of neurons from adult brain stem cells during recovery afterin the adult mammalian brain. J Neurosci 17, 5046–5061 (

  4. Brain as quantum-like computer

    E-Print Network [OSTI]

    Andrei Khrennikov

    2005-03-24T23:59:59.000Z

    We present a contextualist statistical realistic model for quantum-like representations in physics, cognitive science and psychology. We apply this model to describe cognitive experiments to check quantum-like structures of mental processes. The crucial role is played by interference of probabilities for mental observables. Recently one of such experiments based on recognition of images was performed. This experiment confirmed our prediction on quantum-like behaviour of mind. In our approach ``quantumness of mind'' has no direct relation to the fact that the brain (as any physical body) is composed of quantum particles. We invented a new terminology ``quantum-like (QL) mind.'' Cognitive QL-behaviour is characterized by nonzero coefficient of interference $\\lambda.$ This coefficient can be found on the basis of statistical data. There is predicted not only $\\cos \\theta$-interference of probabilities, but also hyperbolic $\\cosh \\theta$-interference. This interference was never observed for physical systems, but we could not exclude this possibility for cognitive systems. We propose a model of brain functioning as QL-computer (there is discussed difference between quantum and QL computers).

  5. Occupational Injury Rate Estimates in Magnetic Fusion Experiments

    SciTech Connect (OSTI)

    cadwallader, lee

    2006-11-01T23:59:59.000Z

    In nuclear facilities, there are two primary aspects of occupational safety. The first aspect is radiological safety, which has rightly been treated in detail in nuclear facilities. Radiological exposure data have been collected from the existing tokamaks to serve as forecasts for ITER radiation safety. The second aspect of occupational safety, “traditional” industrial safety, must also be considered for a complete occupational safety program. Industrial safety data on occupational injury rates from the JET and TFTR tokamaks, three accelerators, and U.S. nuclear fission plants have been collected to set industrial safety goals for the ITER operations staff. The results of this occupational safety data collection and analysis activity are presented here. The data show that an annual lost workday case rate of 0.3 incidents per 100 workers is a conceivable goal for ITER operations.

  6. Monte Carlo simulation of quantum Zeno effect in the brain

    E-Print Network [OSTI]

    Danko Georgiev

    2014-12-11T23:59:59.000Z

    Environmental decoherence appears to be the biggest obstacle for successful construction of quantum mind theories. Nevertheless, the quantum physicist Henry Stapp promoted the view that the mind could utilize quantum Zeno effect to influence brain dynamics and that the efficacy of such mental efforts would not be undermined by environmental decoherence of the brain. To address the physical plausibility of Stapp's claim, we modeled the brain using quantum tunneling of an electron in a multiple-well structure such as the voltage sensor in neuronal ion channels and performed Monte Carlo simulations of quantum Zeno effect exerted by the mind upon the brain in the presence or absence of environmental decoherence. The simulations unambiguously showed that the quantum Zeno effect breaks down for timescales greater than the brain decoherence time. To generalize the Monte Carlo simulation results for any n-level quantum system, we further analyzed the change of brain entropy due to the mind probing actions and proved a theorem according to which local projections cannot decrease the von Neumann entropy of the unconditional brain density matrix. The latter theorem establishes that Stapp's model is physically implausible but leaves a door open for future development of quantum mind theories provided the brain has a decoherence-free subspace.

  7. Discriminative, Semantic Segmentation of Brain Tissue in MR Images

    E-Print Network [OSTI]

    Soatto, Stefano

    Discriminative, Semantic Segmentation of Brain Tissue in MR Images Zhao Yi1 , Antonio Criminisi2 , Jamie Shotton2 , and Andrew Blake2 1 University of California, Los Angeles, USA. zyi@ucla.edu. 2 is presented for the automatic segmentation and classification of brain tissue from 3D MR scans. It uses

  8. DISTRIBUTED, WEB-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE

    E-Print Network [OSTI]

    DISTRIBUTED, WEB-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE A Thesis by WONRYULL KOH Submitted-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE A Thesis by WONRYULL KOH Submitted to Texas A&M University in partial) __________________________ Ian S. Russell (Member) __________________________ Wei Zhao (Head of Department

  9. COMPUTATIONAL ROLE OF DISINHIBITION IN BRAIN FUNCTION A Dissertation

    E-Print Network [OSTI]

    Choe, Yoonsuck

    COMPUTATIONAL ROLE OF DISINHIBITION IN BRAIN FUNCTION A Dissertation by YINGWEI YU Submitted OF DISINHIBITION IN BRAIN FUNCTION A Dissertation by YINGWEI YU Submitted to the Office of Graduate Studies Takashi Yamauchi Head of Department, Valerie E. Taylor August 2006 Major Subject: Computer Science #12;iii

  10. aggressive brain tumor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    aggressive brain tumor First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain oxytocin correlates with...

  11. auditory brain stem implantation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    auditory brain stem implantation First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Auditory Brain Stem...

  12. alzheimer disease brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alzheimer disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

  13. adult brain tumor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    brain tumor First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Transcriptional signature of an adult brain...

  14. aging brain relevance: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    aging brain relevance First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain Evolution Relevant to P....

  15. alzheimers disease brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alzheimers disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

  16. american brain tumor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    american brain tumor First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Efficient Multilevel Brain Tumor...

  17. auditory brain stem implants: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    brain stem implants First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Auditory Brain Stem Response to...

  18. auditory brain stem: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    brain stem First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Auditory Brain Stem Response to Complex...

  19. animal brain tissues: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    animal brain tissues First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Temperature Effects on Brain...

  20. avian brain tissue: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    brain tissue First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Song recognition in the avian brain...

  1. abnormal brain mri: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    abnormal brain mri First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Improvement of MRI brain...

  2. acute brain slices: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    acute brain slices First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain Slice Chamber System Biology...

  3. auditory brain regions: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    auditory brain regions First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 930 Brain imaging Sex...

  4. amusic brain lost: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    amusic brain lost First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 doi:10.1093brainawl204 Brain...

  5. adult mice brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    mice brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Survey of Brain Variations of Young Adult...

  6. acetazolamide stress brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    acetazolamide stress brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Changes in Brain MicroRNAs...

  7. affects brain activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    affects brain activity First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain Research, 347(1985)85-93...

  8. Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 Recent advances in neuroimaging techniques provide great potentials for effective diagnosis of Alzheimer. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

  9. Spatial Mapping of Protein Abundances in the Mouse Brain by Voxelation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mapping of Protein Abundances in the Mouse Brain by Voxelation Integrated with High-Throughput Liquid Chromatography Spatial Mapping of Protein Abundances in the Mouse Brain by...

  10. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

  11. 2003 East Tennessee Technology Park Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-05-23T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for the East Tennessee Technology Park (K-25).The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The Illness and Injury Surveillance Program monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  12. Multifocal brain radionecrosis masquerading as tumor dissemination

    SciTech Connect (OSTI)

    Safdari, H.; Boluix, B.; Gros, C.

    1984-01-01T23:59:59.000Z

    The authors report on an autopsy-proven case of multifocal widespread radionecrosis involving both cerebral hemispheres and masquerading as tumor dissemination on a CT scan done 13 months after complete resection of an oligodendroglioma followed by radiation therapy. This case demonstrates that radiation damage may be present in a CT scan as a multifocal, disseminated lesion. Since the survival of brain-tumor patients who have undergone radiation therapy is prolonged by aggressive therapy, the incidence and variability of radiation-induced complications in such cases is likely to increase. For similar reasons, the radionecrosis in such cases should be taken into consideration. A short review of the CT scan findings and diagnostic and therapeutic considerations in a case of widespread radionecrosis is presented. The need for appropriate diagnosis and subsequent life-saving management is emphasized.

  13. Parallel multiscale simulations of a brain aneurysm

    SciTech Connect (OSTI)

    Grinberg, Leopold [Division of Applied Mathematics, Brown University, Providence, RI 02912 (United States)] [Division of Applied Mathematics, Brown University, Providence, RI 02912 (United States); Fedosov, Dmitry A. [Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich 52425 (Germany)] [Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Jülich 52425 (Germany); Karniadakis, George Em, E-mail: george_karniadakis@brown.edu [Division of Applied Mathematics, Brown University, Providence, RI 02912 (United States)

    2013-07-01T23:59:59.000Z

    Cardiovascular pathologies, such as a brain aneurysm, are affected by the global blood circulation as well as by the local microrheology. Hence, developing computational models for such cases requires the coupling of disparate spatial and temporal scales often governed by diverse mathematical descriptions, e.g., by partial differential equations (continuum) and ordinary differential equations for discrete particles (atomistic). However, interfacing atomistic-based with continuum-based domain discretizations is a challenging problem that requires both mathematical and computational advances. We present here a hybrid methodology that enabled us to perform the first multiscale simulations of platelet depositions on the wall of a brain aneurysm. The large scale flow features in the intracranial network are accurately resolved by using the high-order spectral element Navier–Stokes solver N??T?r. The blood rheology inside the aneurysm is modeled using a coarse-grained stochastic molecular dynamics approach (the dissipative particle dynamics method) implemented in the parallel code LAMMPS. The continuum and atomistic domains overlap with interface conditions provided by effective forces computed adaptively to ensure continuity of states across the interface boundary. A two-way interaction is allowed with the time-evolving boundary of the (deposited) platelet clusters tracked by an immersed boundary method. The corresponding heterogeneous solvers (N??T?r and LAMMPS) are linked together by a computational multilevel message passing interface that facilitates modularity and high parallel efficiency. Results of multiscale simulations of clot formation inside the aneurysm in a patient-specific arterial tree are presented. We also discuss the computational challenges involved and present scalability results of our coupled solver on up to 300 K computer processors. Validation of such coupled atomistic-continuum models is a main open issue that has to be addressed in future work.

  14. Brachial Plexus Injury from CT-Guided RF Ablation Under General Anesthesia

    SciTech Connect (OSTI)

    Shankar, Sridhar, E-mail: shankars@ummhc.org; Sonnenberg, Eric van; Silverman, Stuart G.; Tuncali, Kemal [Brigham and Women's Hospital, Department of Radiology (United States); Flanagan, Hugh L. [Brigham and Women's Hospital, Department of Anesthesia (United States); Whang, Edward E. [Brigham and Women's Hospital, Department of Surgery (United States)

    2005-06-15T23:59:59.000Z

    Brachial plexus injury in a patient under general anesthesia (GA) is not uncommon, despite careful positioning and, particularly, awareness of the possibility. The mechanism of injury is stretching and compression of the brachial plexus over a prolonged period. Positioning the patient within the computed tomography (CT) gantry for abdominal or chest procedures can simulate a surgical procedure, particularly when GA is used. The potential for brachial plexus injury is increased if the case is prolonged and the patient's arms are raised above the head to avoid CT image degradation from streak artifacts. We report a case of profound brachial plexus palsy following a CT-guided radiofrequency ablation procedure under GA. Fortunately, the patient recovered completely. We emphasize the mechanism of injury and detail measures to combat this problem, such that radiologists are aware of this potentially serious complication.

  15. Computational modeling of trabecular bone in lower extremity injuries due to impact

    E-Print Network [OSTI]

    Pino, Wendy

    2013-01-01T23:59:59.000Z

    Lower extremity injuries resulting from improvised explosive devices (IEDs) pose a serious threat to the safety of military troops. Reports from Operation Iraqi Freedom and Operation Enduring Freedom identify IEDs as the ...

  16. Influence of year and genetic factors on chilling injury susceptibility in peach (Prunus persica (L.) Batsch)

    E-Print Network [OSTI]

    Crisosto, Carlos H.

    injury (CI) or internal breakdown (IB). This disorder, triggered by exposure to cold storage temperatures losses in the fresh and processed peach and nectarine industries. This study is an important first step

  17. Transportation Time In A Rural State Following Splenic Injury: Does Time Matter

    E-Print Network [OSTI]

    Ward, Jeanette G.

    2014-05-31T23:59:59.000Z

    Background: Failure rates remain high following attempted non-operative treatment of spleen injuries despite progress made in identifying risk factors. Over the past thirty years, transportation times were excluded from ...

  18. Efficient analysis of ordinal data from clinical trials in head injury 

    E-Print Network [OSTI]

    McHugh, Gillian Stephanie

    2012-06-30T23:59:59.000Z

    Many promising Phase II trials have been carried out in head injury however to date there has been no successful translation of the positive results from these explanatory trials into improved patient outcomes in Phase ...

  19. Motor Vehicle Crash-Associated Eye Injuries Presenting to U.S. Emergency Departments

    E-Print Network [OSTI]

    Armstrong, Grayson W; Chen, Allison J; Linakis, James G; Mello, Michael J; Greenberg, Paul B

    2014-01-01T23:59:59.000Z

    morbidity associated with airbag deployment: a report ofS, Virgili A. Effects of airbag deployment: lesions,Kress TA, Porta DJ, et al. Airbag-induced eye injuries: a

  20. Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury

    E-Print Network [OSTI]

    Milwid, John Miles

    2012-01-01T23:59:59.000Z

    Acute kidney injury is a devastating syndrome that afflicts over 2,000,000 people in the US per year, with an associated mortality of greater than 70% in severe cases. Unfortunately, standard-of-care treatments are not ...

  1. Role of endothelial progenitor cells in acute vascular injury in man 

    E-Print Network [OSTI]

    Padfield, Gareth John

    2013-11-29T23:59:59.000Z

    Percutaneous coronary intervention (PCI) acutely improves coronary blood flow and myocardial perfusion but at the expense of endovascular laceration and endothelial denudation. PCI associated vascular injury is associated with intense inflammation...

  2. Dose impact in radiographic lung injury following lung SBRT: Statistical analysis and geometric interpretation

    SciTech Connect (OSTI)

    Yu, Victoria; Kishan, Amar U.; Cao, Minsong; Low, Daniel; Lee, Percy; Ruan, Dan, E-mail: druan@mednet.ucla.edu [Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024 (United States)] [Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024 (United States)

    2014-03-15T23:59:59.000Z

    Purpose: To demonstrate a new method of evaluating dose response of treatment-induced lung radiographic injury post-SBRT (stereotactic body radiotherapy) treatment and the discovery of bimodal dose behavior within clinically identified injury volumes. Methods: Follow-up CT scans at 3, 6, and 12 months were acquired from 24 patients treated with SBRT for stage-1 primary lung cancers or oligometastic lesions. Injury regions in these scans were propagated to the planning CT coordinates by performing deformable registration of the follow-ups to the planning CTs. A bimodal behavior was repeatedly observed from the probability distribution for dose values within the deformed injury regions. Based on a mixture-Gaussian assumption, an Expectation-Maximization (EM) algorithm was used to obtain characteristic parameters for such distribution. Geometric analysis was performed to interpret such parameters and infer the critical dose level that is potentially inductive of post-SBRT lung injury. Results: The Gaussian mixture obtained from the EM algorithm closely approximates the empirical dose histogram within the injury volume with good consistency. The average Kullback-Leibler divergence values between the empirical differential dose volume histogram and the EM-obtained Gaussian mixture distribution were calculated to be 0.069, 0.063, and 0.092 for the 3, 6, and 12 month follow-up groups, respectively. The lower Gaussian component was located at approximately 70% prescription dose (35 Gy) for all three follow-up time points. The higher Gaussian component, contributed by the dose received by planning target volume, was located at around 107% of the prescription dose. Geometrical analysis suggests the mean of the lower Gaussian component, located at 35 Gy, as a possible indicator for a critical dose that induces lung injury after SBRT. Conclusions: An innovative and improved method for analyzing the correspondence between lung radiographic injury and SBRT treatment dose has been demonstrated. Bimodal behavior was observed in the dose distribution of lung injury after SBRT. Novel statistical and geometrical analysis has shown that the systematically quantified low-dose peak at approximately 35 Gy, or 70% prescription dose, is a good indication of a critical dose for injury. The determined critical dose of 35 Gy resembles the critical dose volume limit of 30 Gy for ipsilateral bronchus in RTOG 0618 and results from previous studies. The authors seek to further extend this improved analysis method to a larger cohort to better understand the interpatient variation in radiographic lung injury dose response post-SBRT.

  3. Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Firouzi M, Moshayedi P, Saberi H, Mobasheri H, Abolhassaniwith material of fetal origin. Saberi et al [7] reportedtrial. Brain 2008, 7. Saberi H, Moshayedi P, Aghayan HR,

  4. acrolein-induced cell injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    21 22 23 24 25 Next Page Last Page Topic Index 1 Acrolein induces oxidative stress in brain mitochondria Jian Luo, Riyi Shi* Engineering Websites Summary: Acrolein induces...

  5. acid-induced lung injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 80...

  6. aspirin-induced gastric injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 34 Medullary...

  7. acetaminophen-induced liver injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 54 In vitro...

  8. acetaminophen-induced cell injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 54...

  9. alcohol-related injury risk: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 23 Risk...

  10. arsenic-induced renal injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 42...

  11. alcohol-induced liver injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 64 In vitro...

  12. a-induced liver injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 53 In vitro...

  13. arsenite-induced oxidative injury: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    activity in the ADRIA project concerns the performance of numerical simulations of the brain response to human head loading during car Verhoeve Bovendeerd Wismans 33...

  14. Poisson Regression Analysis of Illness and Injury Surveillance Data

    SciTech Connect (OSTI)

    Frome E.L., Watkins J.P., Ellis E.D.

    2012-12-12T23:59:59.000Z

    The Department of Energy (DOE) uses illness and injury surveillance to monitor morbidity and assess the overall health of the work force. Data collected from each participating site include health events and a roster file with demographic information. The source data files are maintained in a relational data base, and are used to obtain stratified tables of health event counts and person time at risk that serve as the starting point for Poisson regression analysis. The explanatory variables that define these tables are age, gender, occupational group, and time. Typical response variables of interest are the number of absences due to illness or injury, i.e., the response variable is a count. Poisson regression methods are used to describe the effect of the explanatory variables on the health event rates using a log-linear main effects model. Results of fitting the main effects model are summarized in a tabular and graphical form and interpretation of model parameters is provided. An analysis of deviance table is used to evaluate the importance of each of the explanatory variables on the event rate of interest and to determine if interaction terms should be considered in the analysis. Although Poisson regression methods are widely used in the analysis of count data, there are situations in which over-dispersion occurs. This could be due to lack-of-fit of the regression model, extra-Poisson variation, or both. A score test statistic and regression diagnostics are used to identify over-dispersion. A quasi-likelihood method of moments procedure is used to evaluate and adjust for extra-Poisson variation when necessary. Two examples are presented using respiratory disease absence rates at two DOE sites to illustrate the methods and interpretation of the results. In the first example the Poisson main effects model is adequate. In the second example the score test indicates considerable over-dispersion and a more detailed analysis attributes the over-dispersion to extra-Poisson variation. The R open source software environment for statistical computing and graphics is used for analysis. Additional details about R and the data that were used in this report are provided in an Appendix. Information on how to obtain R and utility functions that can be used to duplicate results in this report are provided.

  15. 2003 Y-12 National Security Complex Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-05-23T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for Y-12. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  16. 2003 Pantex Plant Annual Illness and Injury Surveillance Report, Revised September 2007

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-10-05T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for the Pantex Plant. DOE is commited to assuring the health and safety of its workers. This includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  17. 2003 Kansas City Plant Annual Illness and Injury Surveillance Report, Revised September 2007

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-10-04T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for the Kansas City Plant. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  18. 2003 Fernald Environmental Management Project Annual Illness and Injury Surveillance Report, Revised September 2007

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-10-04T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for the Fernald Environmental Management Project. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  19. 2003 Los Alamos National Laboratory Annual Illness and Injury Surveillance Report, Revised September 2007

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-10-04T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for Los Alamos National Lab. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.

  20. 2003 Sandia National Laboratories--Albuquerque Annual Illness and Injury Surveillance Report

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Illness and Injury Prevention Programs

    2007-05-23T23:59:59.000Z

    Annual Illness and Injury Surveillance Program report for 2003 for Sandia National Laboratories-Albuquerque. The U.S. Department of Energy’s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. The IISP monitors illnesses and health conditions that result in an absence of workdays, occupational injuries and illnesses, and disabilities and deaths among current workers.