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1

Chapter 16 - Traumatic Brain Injury  

Science Journals Connector (OSTI)

Abstract Traumatic brain injury (TBI) is a major public health burden sustained by millions of people annually. The effects of TBI can be characterized based on clinical severity or underlying pathology, with both factors influencing expected recovery. Acute factors involved in the pathophysiology of TBI have been relatively well explored, but chronic effects require further investigation. Of specific interest is the relationship between TBI and neurodegenerative disease, including chronic traumatic encephalopathy (CTE). Originally found in boxers, CTE has been diagnosed in a wide variety of individuals who had been exposed to head trauma. Although the focal perivascular clusters of hyperphosphorylated tau diagnostic of CTE may be found as early as the second decade, the first clinical signs of CTE are not typically observed until one's thirties or forties. Animal models of CTE are under development, as well as in vivo diagnostic tools utilizing the clinical assessment and analysis of biomarkers.

Daniel H. Daneshvar; Ann C. McKee

2015-01-01T23:59:59.000Z

2

Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms in OEF/OIF Veterans : : A Combined Diffusion Tensor Imaging and Cortical Thickness Study  

E-Print Network (OSTI)

injury in mild traumatic brain injury: A diffusion tensoralteration after traumatic brain injury experienced duringE. (1999). Mild traumatic brain injury. Neuropsychological

Sorg, Scott Francis

2013-01-01T23:59:59.000Z

3

Neuropathology Following Repeated Traumatic Brain Injury and the Influence of Inflammatory Status on Injury Outcome  

E-Print Network (OSTI)

of traumatic brain injury." Brain Pathol 19(2): 214- Colgan,Quantitative MRI analysis of brain volume changes due toand causes of traumatic brain injury." Brain Pathol 5(4):

Donovan, Virginia

2014-01-01T23:59:59.000Z

4

Traumatic Brain Injury Protection: Blast Pressure Sensors in...  

NLE Websites -- All DOE Office Websites (Extended Search)

Find More Like This Return to Search Traumatic Brain Injury Protection: Blast Pressure Sensors in Helmets Lawrence Livermore National Laboratory Contact LLNL About This Technology...

5

The Ketamine Effect on ICP in Traumatic Brain Injury  

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Our goal was to perform a systematic review of the literature on the use of ketamine in traumatic brain injury (TBI) and its effects on intracranial pressure (ICP). All articles from MEDLINE, BIOSIS, EMBASE, G...

F. A. Zeiler; J. Teitelbaum; M. West; L. M. Gillman

2014-08-01T23:59:59.000Z

6

Exosome platform for diagnosis and monitoring of traumatic brain injury  

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...information-processing mechanisms in the brain compiled and edited by Lawrence Edelstein...for diagnosis and monitoring of traumatic brain injury Douglas D. Taylor Cicek Gercel-Taylor...information-processing mechanisms in the brain . We have previously demonstrated the release...

2014-01-01T23:59:59.000Z

7

Computational Simulation and Visualization of Traumatic Brain Injuries  

E-Print Network (OSTI)

Computational Simulation and Visualization of Traumatic Brain Injuries Martin Burtscher School the human brain dynamics in realistic 2D cross-sections during trau- matic scenarios corresponding-Voigt Partial Dif- ferential Equations that treat the brain tissue as a viscoelastic solid and on our nonlinear

Burtscher, Martin

8

Neuropathology Following Repeated Traumatic Brain Injury and the Influence of Inflammatory Status on Injury Outcome  

E-Print Network (OSTI)

A mouse model of blast-induced mild traumatic brain injury."models of mTBI have reported changes in RD at 7 and 30 days following blast injury (

Donovan, Virginia

2014-01-01T23:59:59.000Z

9

Progesterone for Traumatic Brain Injury — Resisting the Sirens' Song  

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The results of two randomized, controlled trials of the neurosteroid progesterone in patients with traumatic brain injury (TBI), now published in the Journal,, showed no benefit with respect to favorable functional outcome at 6 months, as assessed by means of the Extended Glasgow Outcome Scale (GOS-E... The results of two randomized, controlled trials of the neurosteroid progesterone in patients with traumatic brain injury (TBI), now published in the Journal, 1,2 showed no benefit with respect to favorable functional outcome at 6 months, as assessed by ...

2014-12-10T23:59:59.000Z

10

Quantitative Evaluation of NIRS Probes and Imaging Protocol for Traumatic Brain Injury (TBI)  

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Realistic head models are used to assess the information content in regions of the brain relevant to monitoring traumatic brain injury patients with commercial NIRS probes,...

Clancy, Michael; Belli, Anthony; Davies, David; Lucas, Sam; Dehghani, Hamid

11

Routine Repeat Head CT may not be Indicated in Patients on Anticoagulant/Antiplatelet Therapy Following Mild Traumatic Brain Injury  

E-Print Network (OSTI)

and an intracranial bleed. J Trauma. brain injury deaths andFollowing Mild Traumatic Brain Injury Kevin C. McCammack,after mild traumatic brain injury (TBI) are controversial.

McCammack, Kevin C.; Sadler, Charlotte; Guo, Yueyang; Ramaswamy, Raja S; Farid, Nikdokht

2015-01-01T23:59:59.000Z

12

Surgical management of the wrist in children with cerebral palsy and traumatic brain injury  

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The majority of children with hemiplegia/quadriplegia resulting from cerebral palsy or traumatic brain injury demonstrate upper extremity disability related to spasticity, weakness, movement disorders, abnorma...

L. Andrew Koman; Beth Paterson Smith

2014-12-01T23:59:59.000Z

13

A Clinical Trial of Progesterone for Severe Traumatic Brain Injury  

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...groups individually instead of the entire group, increasing the sensitivity of the analysis. The analysis used a Cochran–Mantel–Haenszel chi-square test with adjustment for geographic region. Results. Study Participants and Drug Levels. Patients were recruited from July 2010 through September 2013, with... Traumatic brain injury (TBI) is a major cause of death and disability, with large direct and indirect costs to society. In the United States, more than 1.7 million persons have a TBI annually,1 and the annual burden of TBI has been estimated at more than $...

2014-12-10T23:59:59.000Z

14

Very Early Administration of Progesterone for Acute Traumatic Brain Injury  

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.... After randomization, patients were included in the primary analysis under the intention-to-treat principle. The primary efficacy hypothesis was tested with the use of a generalized linear model relating the probability of a favorable outcome to the study treatment, with adjustment for index GCS score... More than 2.4 million emergency department visits, hospitalizations, or deaths are related to traumatic brain injury (TBI) annually, and approximately 5.3 million Americans are living with disability from TBI. The aggregate annual cost of TBI in the ...

2014-12-10T23:59:59.000Z

15

Material Modeling and Development of a Realistic Dummy Testing Blast Induced Traumatic Brain Injury  

E-Print Network (OSTI)

Material Modeling and Development of a Realistic Dummy Head for Testing Blast Induced Traumatic Brain Injury S. G. M. Hossain1, C. A. Nelson1, T. Boulet2, M. Arnoult2, L. Zhang2, A. Holmberg2, J. Hein occurrence rate of traumatic brain injury (TBI) ­ 1.4 million people in US per year ­ 50,000 deaths ­ 235

Farritor, Shane

16

In Silico Investigation of Intracranial Blast Mitigation with Relevance to Military Traumatic Brain Injury  

E-Print Network (OSTI)

Blast-induced traumatic brain injury is the most prevalent military injury in Iraq and Afghanistan, yet little is known about the mechanical effects of blasts on the human head, and still less is known about how personal ...

Nyein, Michelle K.

17

Post-Traumatic Stress Disorder (PTSD) Symptoms as Predictors of Suicide Behavior Among Veterans with and without a History of Traumatic Brain Injury (TBI)  

E-Print Network (OSTI)

POST-TRAUMATIC STRESS DISORDER (PTSD) SYMPTOMS AS PREDICTORS OF SUICIDE BEHAVIOR AMONG VETERANS WITH AND WITHOUT A HISTORY OF TRAUMATIC BRAIN INJURY (TBI) A Dissertation by EDGAR JAVIER VILLARREAL Submitted to the Office...-Traumatic Stress Disorder (PTSD) Symptoms as Predictors of Suicide Behavior among Veterans with and without a History of Traumatic Brain Injury (TBI) Copyright 2012 Edgar Javier Villarreal POST-TRAUMATIC STRESS DISORDER (PTSD) SYMPTOMS AS PREDICTORS...

Villarreal, Edgar Javier

2012-10-19T23:59:59.000Z

18

The influence of mild traumatic brain injury on the temporal distribution of attention  

Science Journals Connector (OSTI)

The purpose of this study was to examine whether the temporal dynamics of attention was deficient in participants who have recently experienced mild traumatic brain injury (mTBI). For this purpose the rapid se...

Alicia McIntire; Jeanne Langan; Charlene Halterman…

2006-09-01T23:59:59.000Z

19

Systems Biology and Theranostic Approach to Drug Discovery and Development to Treat Traumatic Brain Injury  

Science Journals Connector (OSTI)

Traumatic brain injury is a significant disease affecting 1.4 to 2 million patients every year in the USA. Currently, there are no FDA-approved therapeutic remedies to treat TBI despite the fact that there hav...

Zhiqun Zhang; Stephen F. Larner…

2010-01-01T23:59:59.000Z

20

Association of Traumatic Brain Injuries With Vomiting in Children With Blunt Head Trauma  

Science Journals Connector (OSTI)

Study objective We aimed to determine the prevalence of traumatic brain injuries in children who vomit after minor blunt head trauma, particularly when the vomiting occurs without other findings suggestive of traumatic brain injury (ie, isolated vomiting). We also aimed to determine the relationship between the timing and degree of vomiting and traumatic brain injury prevalence. Methods This was a secondary analysis of children younger than 18 years with minor blunt head trauma. Clinicians assessed for history and characteristics of vomiting at the initial evaluation. We assessed for the prevalence of clinically important traumatic brain injury and traumatic brain injury on computed tomography (CT). Results Of 42,112 children enrolled, 5,557 (13.2%) had a history of vomiting, of whom 815 of 5,392 (15.1%) with complete data had isolated vomiting. Clinically important traumatic brain injury occurred in 2 of 815 patients (0.2%; 95% confidence interval [CI] 0% to 0.9%) with isolated vomiting compared with 114 of 4,577 (2.5%; 95% CI 2.1% to 3.0%) with nonisolated vomiting (difference –2.3%, 95% CI –2.8% to –1.5%). Of patients with isolated vomiting for whom CT was performed, traumatic brain injury on CT occurred in 5 of 298 (1.7%; 95% CI 0.5% to 3.9%) compared with 211 of 3,284 (6.4%; 95% CI 5.6% to 7.3%) with nonisolated vomiting (difference –4.7%; 95% CI –6.0% to –2.4%). We found no significant independent associations between prevalence of clinically important traumatic brain injury and traumatic brain injury on CT with either the timing of onset or time since the last episode of vomiting. Conclusion Traumatic brain injury on CT is uncommon and clinically important traumatic brain injury is very uncommon in children with minor blunt head trauma when vomiting is their only sign or symptom. Observation in the emergency department before determining the need for CT appears appropriate for many of these children.

Peter S. Dayan; James F. Holmes; Shireen Atabaki; John Hoyle Jr.; Michael G. Tunik; Richard Lichenstein; Elizabeth Alpern; Michelle Miskin; Nathan Kuppermann

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Traumatic Brain Injury: The “Signature Injury” of the Iraq War  

E-Print Network (OSTI)

news/nationworld/iraq/bal- factorvii,0,2855253.storygallery?The “Signature Injury” of the Iraq War by Tania Aftandiliansremains undi- lives in Iraq; however, funding is severely

Aftandilians, Tania

2009-01-01T23:59:59.000Z

22

Tat-9c, a Tat-fusion Cysteine-rich Peptide, Attenuates Behaviour Deficits following Traumatic Brain Injury in Rats.  

E-Print Network (OSTI)

??Peroxynitrite, a highly oxidative molecule, plays a role in neuronal cell death following traumatic brain injury (TBI). A peptide comprised of the HIV-1 tat transduction… (more)

Zhang, Wen-Jia

2012-01-01T23:59:59.000Z

23

Mixing oil and water: transcending method boundaries in assistive technology for traumatic brain injury  

Science Journals Connector (OSTI)

A prototype assistive technology for traumatic brain injury has been developed using a combination of formative experiments and contextual design. Both approaches have proved to be essential to the development of a simple communication program using ... Keywords: HCI design and evaluation techniques, assistive technology, brain-body interface, contextual inquiry and design

Eamon Doherty; Gilbert Cockton; Chris Bloor; Dennis Benigno

2000-11-01T23:59:59.000Z

24

Mild Traumatic Brain Injury in U.S. Soldiers Returning from Iraq  

Science Journals Connector (OSTI)

To the Editor: We wish to express a number of concerns about the methods used in the study of mild traumatic brain injury by Hoge et al. (Jan. 31 issue). We learned through firsthand experience in the combat zone that immediately after a concussion, the soldier's reported account is most accurate... To the Editor: We wish to express a number of concerns about the methods used in the study of mild traumatic brain injury by Hoge et al. (Jan. 31 issue).1 We learned through firsthand experience in the combat zone that immediately after a concussion, the ...

2008-05-15T23:59:59.000Z

25

Assessment of traumatic brain injury degree in animal model  

Science Journals Connector (OSTI)

AbstractObjective To establish stable and controllable brain injury with accurate degree and good repeatability in rat model. Methods Controlled cortical impact (CCI) device was used to prepare for the rat brain injury model by the impact head of different model (Group A No. 4, Group B No. 5, Group C No. 6) and the impact depth (Group A: 1.5–2.0 mm, Group B: 2.5–3.0 mm, Group C: 3.5–4.0 mm) with impact time of 0.1 s and impact velocity of 2.5 m/s. Twelve rats with three months of age were used in each group (the impact depth of every two rats was added 1 mm respectively). After modeling for 1 h, magnetic resonance imaging (MRI) was received and brain histopathology was observed to assess degree of injury by model parameters of three groups. Results After modeling of Group A, MRI showed that the cortex structure was damaged with a small amount of bleeding in center and mild edema around, and the total volume of injury was (28.69±4.94) mm3. Pathology revealed the injury was confined to the superficial cortical with mild edema of nerve cell, which was assessed as mild cerebral contusion. While after modeling, MRI of Group B showed that the structure of cortex and medulla were damaged simultaneously and extended to cerebral nuclei zone, with 4 cases of hematoma in the center and larger edema range around, and the total volume of injury was (78.38±9.28) mm3. Pathology revealed the injury range was reached nuclei zone, with swell of nerve cell and mitochondria, which was assessed to moderate cerebral contusion. After modeling of Group C, MRI showed that extensive tissue injury was appeared in cortex and medulla and deep nuclei, with 9 cases of hematoma and large edema signal of surrounding tissue T2WI, while in 5 cases, lateral nucleus of injury signal was increased, and the total volume of injury was (135.89±24.80) mm3. Pathology revealed the deep cerebral nuclei was damaged, with the disappearance of neuronal structure and vacuolization of mitochondria, which was assessed as severe cerebral contusion. MRI changes were consistent with pathological changes in three groups of model, and the injury range was significantly different (Pbrain injury model, which overcomes the randomness in previous injury model and possesses highly unity in iconography and pathology changes. This can provide quantitative modeling reference for clinical research.

Jian-Qiang Chen; Cheng-Cheng Zhang; Hong Lu; Wei Wang

2014-01-01T23:59:59.000Z

26

Care of War Veterans with Mild Traumatic Brain Injury — Flawed Perspectives  

Science Journals Connector (OSTI)

...expectations exert a powerful effect on the persistence of symptoms after concussion. Widespread use of the terms "mild TBI," "signature injury," "invisible wound," and "silent epidemic," as well as patient-education materials that combine mild TBI with more serious types of TBI, are examples of poor risk... Researchers estimate that more than 300,000 U.S. veterans of the wars in Iraq and Afghanistan have sustained a mild traumatic brain injury. Dr. Charles Hoge, Herb Goldberg, and Carl Castro write that the clinical definition of “concussion/mild TBI” ...

Hoge C.W.Goldberg H.M.Castro C.A.

2009-04-16T23:59:59.000Z

27

Severe traumatic brain injury management and clinical outcome using the Lund concept  

Science Journals Connector (OSTI)

Abstract This review covers the main principles of the Lund concept for treatment of severe traumatic brain injury. This is followed by a description of results of clinical studies in which this therapy or a modified version of the therapy has been used. Unlike other guidelines, which are based on meta-analytical approaches, important components of the Lund concept are based on physiological mechanisms for regulation of brain volume and brain perfusion and to reduce transcapillary plasma leakage and the need for plasma volume expanders. There have been nine non-randomized and two randomized outcome studies with the Lund concept or modified versions of the concept. The non-randomized studies indicated that the Lund concept is beneficial for outcome. The two randomized studies were small but showed better outcome in the groups of patients treated according to the modified principles of the Lund concept than in the groups given a more conventional treatment.

L.-O.D. Koskinen; M. Olivecrona; P.O. Grände

2014-01-01T23:59:59.000Z

28

Links between traumatic brain injury and ballistic pressure waves originating in the thoracic cavity and extremities  

E-Print Network (OSTI)

Identifying patients at risk of traumatic brain injury (TBI) is important because research suggests prophylactic treatments to reduce risk of long-term sequelae. Blast pressure waves can cause TBI without penetrating wounds or blunt force trauma. Similarly, bullet impacts distant from the brain can produce pressure waves sufficient to cause mild to moderate TBI. The fluid percussion model of TBI shows that pressure impulses of 15-30 psi cause mild to moderate TBI in laboratory animals. In pigs and dogs, bullet impacts to the thigh produce pressure waves in the brain of 18-45 psi and measurable injury to neurons and neuroglia. Analyses of research in goats and epidemiological data from shooting events involving humans show high correlations (r > 0.9) between rapid incapacitation and pressure wave magnitude in the thoracic cavity. A case study has documented epilepsy resulting from a pressure wave without the bullet directly hitting the brain. Taken together, these results support the hypothesis that bullet imp...

Courtney, Amy

2007-01-01T23:59:59.000Z

29

Structural and functional effects of social isolation on the hippocampus of rats with traumatic brain injury  

Science Journals Connector (OSTI)

Abstract Social isolation has significant long-term psychological and physiological consequences. Both social isolation and traumatic brain injury (TBI) alter normal brain function and structure. However, the influence of social isolation on recovery from TBI is unclear. This study aims to evaluate if social isolation exacerbates the anatomical and functional deficits after TBI in young rats. Juvenile male rats were divided into four groups; sham operated control with social contacts, sham control with social isolation, TBI with social contacts, and TBI with social isolation. During four weeks after brain injury in juvenile rats, we evaluated the animal behaviors by T-maze and open-field tests, recorded brain activity with electrocorticograms and assessed structural changes by histological procedures in the hippocampal dentate gyrus, CA1, and CA3 areas. Our findings revealed significant memory impairments and hyperactivity conditions in rats with TBI and social isolation compared to the other groups. Histological assessments showed an increase of the mean number of dark neurons, apoptotic cells, and caspase-3 positive cells in all tested areas of the hippocampus in TBI rats with and without social isolation compared to sham rats. Furthermore, social isolation significantly increased the number of dark cells, apoptotic neurons, and caspase-3 positive cells in the hippocampal CA3 region in rats with TBI. This study indicates the harmful effect of social isolation on anatomical and functional deficits induced by TBI in juvenile rats. Prevention of social isolation may improve the outcome of TBI.

Babak Khodaie; Ahmad Ali Lotfinia; Milad Ahmadi; Mahmoud Lotfinia; Maryam Jafarian; Fariba Karimzadeh; Philippe Coulon; Ali Gorji

2015-01-01T23:59:59.000Z

30

A Thoracic Mechanism of Mild Traumatic Brain Injury Due to Blast Pressure Waves  

E-Print Network (OSTI)

The mechanisms by which blast pressure waves cause mild to moderate traumatic brain injury (mTBI) are an open question. Possibilities include acceleration of the head, direct passage of the blast wave via the cranium, and propagation of the blast wave to the brain via a thoracic mechanism. The hypothesis that the blast pressure wave reaches the brain via a thoracic mechanism is considered in light of ballistic and blast pressure wave research. Ballistic pressure waves, caused by penetrating ballistic projectiles or ballistic impacts to body armor, can only reach the brain via an internal mechanism and have been shown to cause cerebral effects. Similar effects have been documented when a blast pressure wave has been applied to the whole body or focused on the thorax in animal models. While vagotomy reduces apnea and bradycardia due to ballistic or blast pressure waves, it does not eliminate neural damage in the brain, suggesting that the pressure wave directly affects the brain cells via a thoracic mechanism. ...

Courtney, Amy; 10.1016/j.mehy.2008.08.015

2008-01-01T23:59:59.000Z

31

Reply to Moss et al.: Military and medically relevant models of blast-induced traumatic brain injury vs. ellipsoidal heads and helmets  

E-Print Network (OSTI)

Moss et al. (1) acknowledge the second main conclusion of Nyein et al. (2): that a face shield may significantly mitigate blast-induced traumatic brain injury (TBI). However, they obviate the first and most important ...

Nyein, Michelle K.

32

Use of diffusion tensor imaging to assess the impact of normobaric hyperoxia within at-risk pericontusional tissue after traumatic brain injury  

E-Print Network (OSTI)

and ischaemic pathologies. Mol Cell Biochem 1997; 174: 189–192. 30 Robertson CL. Mitochondrial dysfunction contributes to cell death following traumatic brain injury in adult and immature animals. J Bioenerg Biomembr 2004; 36: 363–368. 31 Verweij BH, Muizelaar... and ischaemic pathologies. Mol Cell Biochem 1997; 174: 189–192. 30 Robertson CL. Mitochondrial dysfunction contributes to cell death following traumatic brain injury in adult and immature animals. J Bioenerg Biomembr 2004; 36: 363–368. 31 Verweij BH, Muizelaar...

Veenith, Tonny V.; Carter, Eleanor L.; Grossac, Julia; Newcombe, Virginia F.; Outtrim, Joanne G.; Nallapareddy, Sridhar; Lupson, Victoria; Correia, Marta M.; Mada, Marius M.; Williams, Guy B.; Menon, David K.; Coles, Jonathan P.

2014-07-09T23:59:59.000Z

33

G. Christina Caballero 1 Ketamine Sedation in Traumatic Brain Injury: Friend or Foe?  

E-Print Network (OSTI)

Pharmacotherapy Education and Research Center, University of Texas Health Sciences Center at San Antonio September TBI related to secondary injury and evolves over hours to days following injury d. Improved outcomes MAP > 70 mmHg Systolic blood pressure > 90 mmHg Oxygenation The brain requires oxygen for glucose

Pillow, Jonathan

34

Modeling and simulation of blast-induced, early-time intracranial wave physics leading to traumatic brain injury.  

SciTech Connect

The objective of this modeling and simulation study was to establish the role of stress wave interactions in the genesis of traumatic brain injury (TBI) from exposure to explosive blast. A high resolution (1 mm{sup 3} voxels), 5 material model of the human head was created by segmentation of color cryosections from the Visible Human Female dataset. Tissue material properties were assigned from literature values. The model was inserted into the shock physics wave code, CTH, and subjected to a simulated blast wave of 1.3 MPa (13 bars) peak pressure from anterior, posterior and lateral directions. Three dimensional plots of maximum pressure, volumetric tension, and deviatoric (shear) stress demonstrated significant differences related to the incident blast geometry. In particular, the calculations revealed focal brain regions of elevated pressure and deviatoric (shear) stress within the first 2 milliseconds of blast exposure. Calculated maximum levels of 15 KPa deviatoric, 3.3 MPa pressure, and 0.8 MPa volumetric tension were observed before the onset of significant head accelerations. Over a 2 msec time course, the head model moved only 1 mm in response to the blast loading. Doubling the blast strength changed the resulting intracranial stress magnitudes but not their distribution. We conclude that stress localization, due to early time wave interactions, may contribute to the development of multifocal axonal injury underlying TBI. We propose that a contribution to traumatic brain injury from blast exposure, and most likely blunt impact, can occur on a time scale shorter than previous model predictions and before the onset of linear or rotational accelerations traditionally associated with the development of TBI.

Ford, Corey C. (University of New Mexico, Albuquerque, NM); Taylor, Paul Allen

2008-02-01T23:59:59.000Z

35

Traumatic brain injury induces neuroinflammation and neuronal degeneration that is associated with escalated alcohol self-administration in rats  

Science Journals Connector (OSTI)

AbstractBackground Traumatic brain injury (TBI) affects millions of people each year and is characterized by direct tissue injury followed by a neuroinflammatory response. The post-TBI recovery period can be associated with a negative emotional state characterized by alterations in affective behaviors implicated in the development of Alcohol Use Disorder in humans. The aim of this study was to test the hypothesis that post-TBI neuroinflammation is associated with behavioral dysfunction, including escalated alcohol intake. Methods Adult male Wistar rats were trained to self-administer alcohol prior to counterbalanced assignment into naďve, craniotomy, and TBI groups by baseline drinking. TBI was produced by lateral fluid percussion (LFP; >2 ATM; 25 ms). Alcohol drinking and neurobehavioral function were measured at baseline and following TBI in all experimental groups. Markers of neuroinflammation (GFAP and ED1) and neurodegeneration (FJC) were determined by fluorescence histochemistry in brains excised at sacrifice 19 days post-TBI. Results The cumulative increase in alcohol intake over the 15 days post-TBI was greater in TBI animals compared to naďve controls. A higher rate of pre-injury alcohol intake was associated with a greater increase in post-injury alcohol intake in both TBI and craniotomy animals. Immediately following TBI, both TBI and craniotomy animals exhibited greater neurobehavioral dysfunction compared to naďve animals. GFAP, IBA-1, ED1, and FJC immunoreactivity at 19 days post-TBI was significantly higher in brains from TBI animals compared to both craniotomy and naďve animals. Conclusions These results show an association between post-TBI escalation of alcohol drinking and marked localized neuroinflammation at the site of injury. Moreover, these results highlight the relevance of baseline alcohol preference in determining post-TBI alcohol drinking. Further investigation to determine the contribution of neuroinflammation to increased alcohol drinking post-TBI is warranted.

Jacques P. Mayeux; Sophie X. Teng; Paige S. Katz; Nicholas W. Gilpin; Patricia E. Molina

2015-01-01T23:59:59.000Z

36

Use of diffusion tensor imaging to assess the impact of normobaric hyperoxia within at-risk pericontusional tissue following traumatic brain injury  

E-Print Network (OSTI)

and ischaemic pathologies. Mol Cell Biochem 1997; 174: 189–192. 30 Robertson CL. Mitochondrial dysfunction contributes to cell death following traumatic brain injury in adult and immature animals. J Bioenerg Biomembr 2004; 36: 363–368. 31 Verweij BH, Muizelaar...

Veenith, T.V.; Carter, E.L.; Grossac, J.; Newcombe, V.F.; Outtrim, J.G.; Nallapareddy, Sridhar; Lupson, Victoria; Correia, M.M.; Mada, Marius M.; Williams, Guy B.; Menon, David K.; Coles, J.P.

2014-07-08T23:59:59.000Z

37

N-3 FATTY ACIDS AND JUVENILE TRAUMATIC BRAIN INJURY: EFFECTS OF DIETARY N-3 FATTY ACID CONTENT, N-3 FATTY ACID STATUS, AND ORALLY DOSED FISH OIL ON SENSORIMOTOR AND BIOCHEMICAL OUTCOMES  

E-Print Network (OSTI)

Children under five years of age are at high risk for sustaining traumatic brain injury (TBI) and tend to have poorer outcomes despite greater neuroplasticity in children. Hence, there is a great need to study TBI specifically ...

Russell, Kristin L.

2013-08-31T23:59:59.000Z

38

A Three-Year Prospective Study of Repeat Head Computed Tomography in Patients with Traumatic Brain Injury  

Science Journals Connector (OSTI)

Background A definitive consensus on the standardization of practice of a routine repeat head CT (RHCT) scan in patients with traumatic intracranial hemorrhage is lacking. We hypothesized that in examinable patients without neurologic deterioration, RHCT scan does not lead to neurosurgical intervention (craniotomy/craniectomy). Study Design This was a 3-year prospective cohort analysis of patients aged 18 years and older, without antiplatelet or anticoagulation therapy, presenting to our level 1 trauma center with intracranial hemorrhage on initial head CT and a follow-up RHCT. Neurosurgical intervention was defined by craniotomy/craniectomy. Neurologic deterioration was defined as altered mental status, focal neurologic deficits, and/or pupillary changes. Results A total of 1,129 patients were included. Routine RHCT was performed in 1,099 patients. The progression rate was 19.7% (216 of 1,099), with subsequent neurosurgical intervention in 4 patients. Four patients had an abnormal neurologic examination, with a Glasgow Coma Scale (GCS) of ?8 requiring intubation. Thirty patients had an RHCT secondary to neurologic deterioration; 53% (16 of 30) had progression on RHCT, of which 75% (12 of 16) required neurosurgical intervention. There was an association between deterioration in neurologic examination and need for neurosurgical intervention (odds ratio 3.98; 95% CI 1.7 to 9.1). The negative predictive value of a deteriorating neurologic examination in predicting the need for neurosurgical intervention was 100% in patients with GCS > 8. Conclusions Routine repeat head CT scan is not warranted in patients with normal neurologic examination. Routine repeat head CT scan does not supplement the need for neurologic examination for determining management in patients with traumatic brain injury.

Bellal Joseph; Hassan Aziz; Viraj Pandit; Narong Kulvatunyou; Ammar Hashmi; Andrew Tang; Moutamn Sadoun; Terence O’Keeffe; Gary Vercruysse; Donald J. Green; Randall S. Friese; Peter Rhee

2014-01-01T23:59:59.000Z

39

Amantadine preserves dopamine level and attenuates depression-like behavior induced by traumatic brain injury in rats  

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Abstract Traumatic brain injury (TBI) often results in multiple neuropsychiatric sequelae, including cognitive, emotional, and behavioral problems. Among them, depression is a common psychiatric symptom, and links to poorer recovery. Amantadine, as an antiparkinsonian, increases dopamine release, and blocks dopamine reuptake, but has recently received attention for its effectiveness as an antidepressant. In the present study, we first induced a post-TBI depression rat model to probe the efficacy of amantadine therapy in reducing post-TBI depression. The DA concentration in the striatum of the injured rats, as well as the degeneration and apoptosis of dopaminergic neurons in the substantia nigra (SN), were checked along with the depression-like behavior. The results showed that amantadine therapy could significantly ameliorate the depression-like behavior, improving the DA level in the striatum and decreasing the degeneration and apoptosis of dopaminergic neurons in the SN. The results indicated that the anti-depression effect may result from the increase of extracellular DA concentration in the striatum and/or the indirect neuroprotection on the dopaminergic neurons in the SN. We conclude that DA plays a critical role in post-TBI depression, and that amantadine shows its potential value in anti-depression treatment for TBI.

Liang Tan; Gongfei Ge; Jun Tang; Chuhua Fu; Wangsheng Duanmu; Yujie Chen; Rong Hu; Jianfeng Sui; Xin Liu; Hua Feng

2015-01-01T23:59:59.000Z

40

Traumatic brain injury  

Science Journals Connector (OSTI)

...logistics of clinical care delivery in the field...optimizing outcome. Clinical care has much in common with...tissue recoil. The cavity reforms and collapses several...associated with poor general health, missed workdays, increased access to medical care and somatic and post-concussive...

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Confined blasts, and the impact of shock wave reflections on a human head and the related traumatic brain injury  

Science Journals Connector (OSTI)

We examine the effects of blast waves in a confined space on a human head model. A finite element human model (FEHM) is exposed to blast waves from explosions, as well as, to the reflected waves from the confinement walls. The intensity of the travelling blast shock waves is measured computationally and compared with experimental results. We monitor the mechanical response of the brain of the FEHM at different stand-off positions, either close to, or away from the surrounding walls in interaction with the travelling blast waves. The skull pressure, brain intracranial pressure (ICP), acceleration, shear stress, and principal stresses and strains are measured as the biomechanical parameters for injury diagnosis and compared for all the situations and stand-off positions considered. The results illustrate that the additional reflected shock waves due to the surrounding walls can dramatically change the brain biomechanical parameters.

Asghar Rezaei; Mehdi Salimi Jazi; Samad Javid; Ghodrat Karami; Mariusz Ziejewski

2014-01-01T23:59:59.000Z

42

Comparison of Quantitative EEG to current clinical decision rules for Head CT use in acute mild traumatic brain injury in the ED  

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Abstract Study Objective We compared the performance of a hand-held Quantitative Electroencephalogram (QEEG) acquisition device to New Orleans Criteria (NOC), Canadian CT Head Rule (CCHR) and National Emergency X-Radiography Utilization Study II (NEXUS II) Rule in predicting intracranial lesions on Head CT in acute mild traumatic brain injury (TBI) in the Emergency Department (ED). Methods Patients between 18-80 years of age who presented to the ED with acute blunt head trauma were enrolled in this prospective observational study at two urban academic \\{EDs\\} in Detroit, Michigan. Data was collected for 10 minutes from frontal leads to determine a QEEG discriminant score that could maximally classify intracranial lesions on Head CT. Results: 152 patients were enrolled from July 2012 to February 2013. 17.1% had acute traumatic intracranial lesions on Head CT. QEEG discriminant score of ? 31 was found to be a good cut-off (AUC = 0.84, 95% CI 0.76-0.93) to classify patients with positive head CT. The sensitivity of QEEG discriminant score was 92.3 (95% CI 73.4-98.6) while the specificity was 57.1 (95% CI 48.0-65.8). The sensitivity and specificity of the decision rules were as follows: NOC 96.1 (95% CI 78.4-99.7) and 15.8 (95% CI 10.1-23.6); CCHR 46.1 (95% CI 27.1-66.2) and 86.5 (95% CI 78.9-91.7); NEXUS II 96.1 (95% CI 78.4-99.7) and 31.7 (95% CI 23.9-40.7). Conclusion At a sensitivity of greater than 90%, QEEG discriminant score had better specificity than NOC and NEXUS II. Only CCHR had better specificity than QEEG discriminant score but at the cost of low (< 50%) sensitivity.

Syed Imran Ayaz; Craig Thomas; Andrew Kulek; Rosa Tolomello; Valerie Mika; Duane Robinson; Patrick Medado; Claire Pearson; Leslie S. Prichep; Brian J. O’Neil

2014-01-01T23:59:59.000Z

43

Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus–CSF nexus  

E-Print Network (OSTI)

model Baboon Lateral head movement acceleration (diffuse injury) Rat (male Wistar) Single blast,blast waves or other TBI-induc- tion procedures (Table 1). The diffuse injury model,

Johanson, Conrad; Stopa, Edward; Baird, Andrew; Sharma, Hari

2011-01-01T23:59:59.000Z

44

Collagen scaffolds for treatment of penetrating brain injury in a rat model  

E-Print Network (OSTI)

Recovery from central nervous system (CNS) injuries is hindered by a lack of spontaneous regeneration. In injuries such as stroke and traumatic brain injury, loss of viable tissue can lead to cavitation as necrotic debris ...

Elias, Paul Z. (Paul Ziad)

2011-01-01T23:59:59.000Z

45

Glycolysis and pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-13C2 glucose  

E-Print Network (OSTI)

recorded at the bedside using ICM+ software (ICM+, University of Cambridge, UK). Microdialysate samples were stored at 4°C (or at –80°C if storage for longer than a few days was necessary) prior to NMR analysis. NMR analysis Brain microdialysate... and inhibit hydrogen peroxide-induced changes in mitochondrial transmembrane potential in Jurkat cells (a cancer cell line).25 Although these two latter studies were not performed in brain, they nevertheless illustrate the Page 18 of 34Journal of Cerebral...

Jalloh, Ibrahim; Carpenter, Keri L. H.; Grice, Peter; Howe, Duncan J.; Mason, Andrew; Gallagher, Clare N.; Helmy, Adel; Murphy, Michael P.; Menon, David K.; Carpenter, T. Adrian; Pickard, John D.; Hutchinson, Peter J.

2014-01-01T23:59:59.000Z

46

The influence of anisotropy on brain injury prediction  

Science Journals Connector (OSTI)

Abstract Traumatic Brain Injury (TBI) occurs when a mechanical insult produces damage to the brain and disrupts its normal function. Numerical head models are often used as tools to analyze \\{TBIs\\} and to measure injury based on mechanical parameters. However, the reliability of such models depends on the incorporation of an appropriate level of structural detail and accurate representation of the material behavior. Since recent studies have shown that several brain regions are characterized by a marked anisotropy, constitutive equations should account for the orientation-dependence within the brain. Nevertheless, in most of the current models brain tissue is considered as completely isotropic. To study the influence of the anisotropy on the mechanical response of the brain, a head model that incorporates the orientation of neural fibers is used and compared with a fully isotropic model. A simulation of a concussive impact based on a sport accident illustrates that significantly lowered strains in the axonal direction as well as increased maximum principal strains are detected for anisotropic regions of the brain. Thus, the orientation-dependence strongly affects the response of the brain tissue. When anisotropy of the whole brain is taken into account, deformation spreads out and white matter is particularly affected. The introduction of local axonal orientations and fiber distribution into the material model is crucial to reliably address the strains occurring during an impact and should be considered in numerical head models for potentially more accurate predictions of brain injury.

C. Giordano; R.J.H. Cloots; J.A.W. van Dommelen; S. Kleiven

2014-01-01T23:59:59.000Z

47

E-Print Network 3.0 - acute post-traumatic brain Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

traumatic brain Search Powered by Explorit Topic List Advanced Search Sample search results for: acute post-traumatic brain Page: << < 1 2 3 4 5 > >> 1 Journal of the International...

48

E-Print Network 3.0 - acute traumatic brain Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: acute traumatic brain Page: << < 1 2 3 4 5 > >> 1 Journal of the International...

49

Numerical Modeling of Brain Dynamics in Traumatic Situations -Impulsive Translations  

E-Print Network (OSTI)

.S.A. Abstract We numerically model the brain dy- namics during and after impulsive head translations using brain injuries appear among boxers and shaken babies despite minimal rotations of their heads. Modeling head translations also helps understand the brain dynamics during head rotations about an arbitrary

Burtscher, Martin

50

Skull flexure from blast waves: a mechanism for brain injury with implications for helmet design  

SciTech Connect

Traumatic brain injury [TBI] has become a signature injury of current military conflicts. The debilitating effects of TBI are long-lasting and costly. Although the mechanisms by which impacts cause TBI have been well researched, the mechanisms by which blasts cause TBI are not understood. Various possibilities have been investigated, but blast-induced deformation of the skull has been neglected. From numerical hydrodynamic simulations, we have discovered that nonlethal blasts can induce sufficient flexure of the skull to generate potentially damaging loads in the brain, even if no impact occurs. The possibility that this mechanism may contribute to TBI has implications for the diagnosis of soldiers and the design of protective equipment such as helmets.

Moss, W C; King, M J; Blackman, E G

2009-04-14T23:59:59.000Z

51

Investigation of Primary Blast Injury and Protection using Sagittal and Transverse Finite Element Head Models.  

E-Print Network (OSTI)

??The prevalence of blast related mild traumatic brain injury (mTBI) in recent military conflicts, attributed in part to an increased exposure to improvised explosive devices… (more)

Singh, Dilaver

2015-01-01T23:59:59.000Z

52

Neuroanatomic-Based Detection Algorithm for Automatic Labeling of Brain Structures in Brain Injury  

Science Journals Connector (OSTI)

The number and grade of injured neuroanatomic structures and the type of injury determine the degree of impairment after a brain injury event and the recovery options of ... (Speeded Up Robust Feature) to label a...

M. Luna; F. Gayá; A. García-Molina…

2014-01-01T23:59:59.000Z

53

Exosome platform for diagnosis and monitoring of traumatic brain injury  

Science Journals Connector (OSTI)

...by current technologies. Furthermore...to sample handling and require strict procedures for collecting, handling and processing...have been applied to these...metabolomic technologies to define...sequencing technologies has expanded...

2014-01-01T23:59:59.000Z

54

The WSU Program for Traumatic Brain Injury Research  

E-Print Network (OSTI)

and Functionalized Magnetic Nanoparticles for Magnetic Resonance Imaging and Theranostics" Abstract: Magnetic for the development of novel MR molecular imaging probes and multifunctional theranostic systems. Sensitive detection targeted magnetic iron oxide nanoparticle MRI probes and other theranostic nano-constructs developed in our

Finley Jr., Russell L.

55

ExecutiveSummary International Initiative for Traumatic Brain Injury Meeting  

E-Print Network (OSTI)

's National Institute of Neurological Disorders and Stroke, and Canada's CIHR - Institute of Neurosciences by 2020. The two-day meeting in Vancouver in October, 2014 began with a review of the progress to date in their countries. A presentation from Australia's Institute of Safety, Compensation and Recovery Research (ISCRR

56

Memantine Alleviates Brain Injury and Neurobehavioral Deficits after Experimental Subarachnoid Hemorrhage  

Science Journals Connector (OSTI)

Subarachnoid hemorrhage (SAH) causes brain injury via glutamate excitotoxicity, which leads to an excessive Ca2+...influx and this starts an apoptotic cascade. Memantine has been proven to reduce brain injury ......

Chih-Yuan Huang; Liang-Chao Wang; Hao-Kuang Wang; Chia-Hsin Pan…

2014-06-01T23:59:59.000Z

57

Computational Modeling of Brain Dynamics during Repetitive Head Motions  

E-Print Network (OSTI)

Computational Modeling of Brain Dynamics during Repetitive Head Motions Igor Szczyrba School motions in traumatic scenarios that are as- sociated with severe brain injuries. Our results are based on the linear Kelvin-Voigt brain injury model, which treats the brain matter as a viscoelastic solid, and on our

Burtscher, Martin

58

The Problem Montana ranks third in the nation for brain injury  

E-Print Network (OSTI)

The Problem Montana ranks third in the nation for brain injury fatalities, and is home to a large population of brain injury survivors suffering from the chronic effects of a these injuries. In addition, Montana has a high percentage of veterans, many returning home with TBIs. The most common causes for brain

Vonessen, Nikolaus

59

Rat injury model under controlled field-relevant primary blast conditions: Acute response to a wide  

E-Print Network (OSTI)

1 1 Rat injury model under controlled field-relevant primary blast conditions: Acute response.edu Keywords: Traumatic Brain Injury, Primary Blast, Mortality, Cellular Membrane Permeability, Lung Injury the risk of sustaining blast induced injury by military personnel and civilians. The blast injury

Farritor, Shane

60

E-Print Network 3.0 - acute brain injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: acute brain injury Page: << < 1 2 3 4 5 > >> 1 Concussion Assessment Research Laboratory The...

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Multidiscipline Modeling in Materials and Structures Emerald Article: A study of the blast-induced brain white-matter damage  

E-Print Network (OSTI)

Multidiscipline Modeling in Materials and Structures Emerald Article: A study of the blast, (2012),"A study of the blast-induced brain white-matter damage and the associated diffuse axonal injury Abstract Purpose ­ Blast-induced traumatic brain injury (TBI) is a signature injury of the current military

Grujicic, Mica

62

Modeling of Human Brain Tissues and Head Injuries Induced by Blast and Ballistic Impact  

E-Print Network (OSTI)

can result from direct impact on the skull, leading to skull fracture and subsequent damage to the brain tissue. Such injuries are penetrating TBIs, which are mainly caused by motor vehicle accidents, sports and work related accidents, and falls...

Kulkarni, Sahil G

2013-11-07T23:59:59.000Z

63

Tympanic-Membrane Perforation as a Marker of Concussive Brain Injury in Iraq  

Science Journals Connector (OSTI)

...principally in the form of roadside improvised explosive devices (IEDs), continues to be the signature mechanism of injury for coalition forces in Iraq. In 2005, the U.S. military reported 10,953 IED attacks, at an average of 30 per day. Combat body armor provides soldiers with considerable protection... This study evaluated 210 U.S. soldiers after blast injury in Iraq. There was a significant association between tympanic-membrane perforation and concussive brain injury.

2007-08-23T23:59:59.000Z

64

The influence of heterogeneous meninges on the brain mechanics under primary blast loading  

E-Print Network (OSTI)

/interphase C. Finite element analysis Blast wave a b s t r a c t In the modeling of brain mechanics subjected mismatch. Ă? 2012 Elsevier Ltd. All rights reserved. 1. Introduction Blast-related traumatic brain injury, 88% of those injuries were caused by expo- sure to blasts resulting from improvised explosive devices

Farritor, Shane

65

Transmission, attenuation and reflection of shear waves in the human brain  

Science Journals Connector (OSTI)

...reflection of shear waves in the human brain Erik H. Clayton 1 * Guy M. Genin 1 Philip...1185, St Louis, MO 63130, USA Traumatic brain injuries (TBIs) are caused by acceleration...methods to measure the motion of the human brain in vivo as the skull was exposed to harmonic...

2012-01-01T23:59:59.000Z

66

Increased Blood Glucose is Related to Disturbed Cerebrovascular Pressure Reactivity After Traumatic Brain Injury  

E-Print Network (OSTI)

Joseph Donnelly Division of Neurosurgery, Department of Clinical Neurosciences, Box 167, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, United Kingdom. United Kingdom Email: jd634@cam.ac.uk Phone: +44 (0) 1223 336946 0DQXVFULSW &OLFN#3... glucose concentration impairs endothelial, and smooth muscle cell responses both in the cerebral and peripheral vasculature. Clearly, further investigation on the link between glucose and pressure reactivity in the TBI population is warranted...

Donnelly, Joseph; Sudhan, Nazneen; Varsos, Georgios V.; Nasr, Nathalie; Jalloh, Ibrahim; Liu, Xiuyun; Dias, Celeste; Sekhon, Mypinder; Carpenter, Keri L. H.; Menon, David K.; Hutchinson, Peter J.; Smielewski, Peter; Czosnyka, Marek

2014-08-15T23:59:59.000Z

67

Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings  

E-Print Network (OSTI)

with im- proved behavioural outcomes for N-acetylcysteine amide (NACA), apparently due to maintenance of mitochondrial glutathione and mitochondrial bioenergetics, and to reduction in oxidative damage (Pandya et al. 2014). These or other mitochondrial...

Jalloh, Ibrahim; Carpenter, Keri L. H.; Helmy, Adel; Carpenter, T. Adrian; Menon, David K.; Hutchinson, Peter J.

2014-11-21T23:59:59.000Z

68

Computational Modeling and Optimization of a Novel Shock Tube to Study Blast Induced Traumatic Brain Injury  

E-Print Network (OSTI)

. Various 2D models to simulate the shock wave propagation in a shock tube to see the effects of varying shock tube geometry and working fluid on the blast profiles were developed. Ranges of different parameters evaluated are: tube length - 5ft to 25ft; tube...

Anumolu, Pratima

2014-08-06T23:59:59.000Z

69

Baroreflex Sensitivity during Positional Changes in Patients with Traumatic Brain Injury  

E-Print Network (OSTI)

heart rate. Use of the sphygmomanometer does not allow forprovided by the sphygmomanometer is useful in the day to dayheart rate) or using a sphygmomanometer or electronic non-

McNair, Norma Dianne

2012-01-01T23:59:59.000Z

70

E-Print Network 3.0 - alkaline chemical injury Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

AcroleinProtein Adducts after Traumatic Spinal Cord Injury Summary: Accumulation of Acrolein-Protein Adducts after Traumatic Spinal Cord Injury Jian Luo,1 Koji Uchida......

71

E-Print Network 3.0 - acid chemical injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

AcroleinProtein Adducts after Traumatic Spinal Cord Injury Summary: Accumulation of Acrolein-Protein Adducts after Traumatic Spinal Cord Injury Jian Luo,1 Koji Uchida......

72

Correction for Liechti et al., Matrix Metalloproteinase Inhibition Lowers Mortality and Brain Injury in Experimental Pneumococcal Meningitis  

Science Journals Connector (OSTI)

...2014 correction Author Corrections Correction for Liechti et al., Matrix Metalloproteinase Inhibition Lowers Mortality and Brain Injury in Experimental Pneumococcal Meningitis Fabian D. Liechti a b Denis Grandgirard a David Leppert c Stephen L. Leib a...

Fabian D. Liechti; Denis Grandgirard; David Leppert; Stephen L. Leib

2014-10-01T23:59:59.000Z

73

Chapter Eight - Diagnosing and Treating Closed Head Injury: Exposing and Defeating the Mild Huge Monster  

Science Journals Connector (OSTI)

One of the leading causes of death and disability worldwide is brain injury. Most cases are mild, and the prevalence of disability and its impact are not well known. In the last 20 years neuroimaging technologies have changed the way we approach traumatic brain injury (TBI), especially mild injury (MTBI), and its sequelae. New treatment tools have been emerging in parallel with diagnostic technologies. Here, these noninvasive tools will be reviewed, especially those with therapeutic value that have a direct impact on brain function, either passively (operant conditioning, neurofeedback) or actively (transcranial electromagnetic stimulation). The main focus will be on EEG as a diagnostic and therapeutic tool for MTBI.

Carlos A. Novo-Olivas

2014-01-01T23:59:59.000Z

74

Occupational Injuries  

NLE Websites -- All DOE Office Websites (Extended Search)

Injuries Injuries Jacqueline Agnew, PhD Burden of Occupational Injury and Illness in U.S. * Study by Leigh et al., 1997 * Estimated incidence, mortality, direct & indirect costs- occupational injury & illness * 1992 data- primary and secondary sources o Census of Fatal Occupational Injuries o National Traumatic Occupational Fatality Study o Annual Survey of Occ. Injuries & Illnesses o Bureau of Labor Statistics, Health Care Financing Administration, etc. Direct & Indirect Costs * Indirect * Lost earnings * Fringe benefits * Home production * Training, restaffing, disruption * Time delays Direct & Indirect Costs * Direct * Physicians, hospitals, nursing homes, rehabilitation, medication * Medical and indemnity insurance administration expenses

75

Biomechanics of brain tissue Thibault P. Prevost a  

E-Print Network (OSTI)

, blast/shock wave prop- agation) leading to traumatic brain injury. Ă? 2010 Acta Materialia Inc. Published, viscoelastic constitutive model. Mixed gray and white matter samples excised from the superior cortex were model was developed to account for the essential features of the tissue response over the entire

Suresh, Subra

76

Visualisation of the intact dura mater and brain surface in infant autopsies: a minimally destructive technique for the post-mortem assessment of head injury  

Science Journals Connector (OSTI)

During the post-mortem examination of babies and young children, it is important to be able to visualise the brain and its coverings, particularly in cases where a head injury is likely to have occurred. In ... t...

Emma C. Cheshire; Roger D. G. Malcomson…

2014-11-01T23:59:59.000Z

77

Chapter 7 - Polyphenols, Nerve Growth Factor, Brain-Derived Neurotrophic Factor, and the Brain  

Science Journals Connector (OSTI)

Abstract The central nervous system (CNS) has a limited capacity to spontaneously regenerate following traumatic injury or disease; therefore, the availability of new, innovative strategies to recover from the alteration in brain structure and function to promote tissue and functional repair would be of great importance. At the present time, many efforts have been carried out to identify strategies or drugs able to prevent or at least attenuate brain damage. This review summarizes the current knowledge of the major bioactivities and the efficacy on the brain of polyphenols and CNS active herbal remedies in order to stimulate interest in evaluating these compounds as potential sources for structurally and functionally novel CNS active drugs. We discuss the role of polyphenols in the brain and their functional implications for the healthy and diseased brain, especially with regard to their ability to modulate neurotrophin functions.

Valentina Carito; Mauro Ceccanti; George Chaldakov; Luigi Tarani; Sara De Nicolň; Stefania Ciafrč; Paola Tirassa; Marco Fiore

2015-01-01T23:59:59.000Z

78

Frequency of intracranial injury in cadavers with head trauma with and without scalp injury in Tehran  

Science Journals Connector (OSTI)

Abstract Traumatic brain injury is a major cause of morbidity, disability and mortality in patients with head injury. The aim of this study was to elucidate the frequency of intracranial injury in cadavers with head trauma with and without scalp injury in Tehran. In this analytical cross-sectional study, we investigated 187 cadavers who died due to head trauma in motor vehicle accident or after falling in Tehran from November 2013 to February 2014. Age, sex, mechanism of trauma, scalp injury, sub-scalp bruising, skull fracture, hemorrhage including subdural hemorrhage (SDH), epidural hemorrhage (EDH), subarachnoid hemorrhage (SAH) and contusion were recorded from examination and autopsy. One hundred and eighty seven cadavers (165 (88.2%) male and 22 (11.8%) female) with head injury with the mean age of 36.14 years (SD = 15) were recruited in this study. Mechanism of trauma was motor vehicle accident in 147 (78.6%) cadavers and falling in 40 (21.4%) cadavers. One hundred and fifty eight (84.5%) had SDH, 44 (23.5%) had EDH, 162 (86.6%) had SAH and 139 (74.3%) had contusion. Hemorrhage was seen in 132 (93%) cadavers who had scalp injury and 36 (80%) cadavers who did not have scalp injury (p = 0.01). Overall, 168 (89.8%) cadavers had hemorrhage and 139 (74.3%) had contusion. There was a significant correlation between intracranial injuries and scalp injury (p head trauma, complete examination should be performed but absence of findings in examination cannot exclude intracranial injury.

Kamran Aghakhani; Mansoure Heidari; Vahid Yousefinejad; Arash Okazi

2014-01-01T23:59:59.000Z

79

Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats: Possible involvement of TLR4/NF-?B-mediated inflammatory pathway  

Science Journals Connector (OSTI)

Abstract Early brain injury (EBI) following subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes. Hence, effective therapeutic strategies targeting on EBI have recently become a major goal in the treatment of SAH patients. Baicalein is a flavonoid that has been shown to offer neuroprotection in kinds of brain injury models. This study investigated the effects of baicalein on EBI in rats following SAH. SAH was inducted in male Sprauge-Dawley rats by injection of fresh non-heparinized arterial blood into the prechiasmatic cistern. Baicalein (30 or 100 mg/kg) or vehicle were administrated 30 min after injury. Neurological deficit, brain edema, blood–brain barrier (BBB) permeability and neural cell apoptosis were assessed. To explore the further mechanisms, the change of toll-like receptor 4 (TLR4) and nuclear factor-?B (NF-?B) signaling pathway and the levels of apoptosis associated proteins were also examined. Our study showed that treatment with baicalein (30 mg/kg) significantly improved neurological function at 24 h after SAH and reduced brain edema at both 24 h and 72 h after SAH. Baicalein also significantly reduced neural cell death, BBB permeability. These changes were associated with the remarkable reductions of TLR4 expression, I?B-? degradation, NF-?B translocation to nucleus, as well as the expressions of matrix metalloproteinase-9, tight junctions protein, interleukin-1? and tumor necrosis factor- ?. These findings suggest that baicalein may ameliorate EBI after SAH potentially via inhibition of inflammation-related pathway.

Chun-xi Wang; Guang-bin Xie; Chen-hui Zhou; Xiang-sheng Zhang; Tao Li; Jian-guo Xu; Ning Li; Ke Ding; Chun-hua Hang; Ji-xin Shi; Meng-liang Zhou

2015-01-01T23:59:59.000Z

80

Shock induces a deficit in the recovery of function after a contusion injury: identifying the relative contributions of the brain and spinal cord  

E-Print Network (OSTI)

: Psychology iii ABSTRACT Shock Induces a Deficit in the Recovery of Function after a Contusion Injury: Identifying the Relative Contributions of the Brain and Spinal Cord. (August 2005) Anne Caroline Bopp, B. S., Indiana State University Chair... for the serotonergic and ___________ This thesis follows the style and format of Journal of Neurotrauma. 2 noradrendergic systems, respectively. (Grahn et al., 1999; Maier et al., 1995a; Maier et al., 1995b; Weiss & Simson, 1986). Recently, it has been...

Bopp, Anne Caroline

2006-10-30T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Combat-related blast injuries : injury types and outcomes  

E-Print Network (OSTI)

U.S. Soldiers returning from Iraq. N Engl J Med. Jan Helmickmilitary convoys in Iraq: an examination of battle injuriesdistinguishing injury of the Iraq war. Brain Injury Resource

Eskridge, Susan Lindsay

2011-01-01T23:59:59.000Z

82

Services on Campus Disability Support Service (DSS) coordinates services that ensure individuals with disabilities  

E-Print Network (OSTI)

with language learning problems, stroke, traumatic brain injury, stuttering, voice problems, accent correction

Li, Teng

83

Post-Traumatic Stress Disorder  

E-Print Network (OSTI)

Post-Traumatic Stress Disorder (PTSD) National Institute of Mental Health U.S. Department of HealtH anD HUman ServiceS · national institutes of Health #12;Contents What is post traumatic stress disorder after seeing or living through a dangerous event. When in danger, it's natural to feel afraid. This fear

Bandettini, Peter A.

84

Improved measurement of brain deformation during mild head acceleration using a novel tagged MRI sequence  

Science Journals Connector (OSTI)

Abstract In vivo measurements of human brain deformation during mild acceleration are needed to help validate computational models of traumatic brain injury and to understand the factors that govern the mechanical response of the brain. Tagged magnetic resonance imaging is a powerful, noninvasive technique to track tissue motion in vivo which has been used to quantify brain deformation in live human subjects. However, these prior studies required from 72 to 144 head rotations to generate deformation data for a single image slice, precluding its use to investigate the entire brain in a single subject. Here, a novel method is introduced that significantly reduces temporal variability in the acquisition and improves the accuracy of displacement estimates. Optimization of the acquisition parameters in a gelatin phantom and three human subjects leads to a reduction in the number of rotations from 72 to 144 to as few as 8 for a single image slice. The ability to estimate accurate, well-resolved, fields of displacement and strain in far fewer repetitions will enable comprehensive studies of acceleration-induced deformation throughout the human brain in vivo.

Andrew K. Knutsen; Elizabeth Magrath; Julie E. McEntee; Fangxu Xing; Jerry L. Prince; Philip V. Bayly; John A. Butman; Dzung L. Pham

2014-01-01T23:59:59.000Z

85

HEAD INJURY ASSESSMENT IN JUVENILE CHINOOK USING THE ALPHA II-SPECTRIN BIOMARKER: EFFECTS OF PRESSURE CHANGES AND PASSAGE THROUGH A REMOVABLE SPILLWAY WEIR  

SciTech Connect

The cytoskeletal protein alpha II-spectrin has specifi c neurodegenerative mechanisms that allow the necrotic (injury-induced) and apoptotic (non-injury-induced) pathways of proteolysis to be differentiated in an immunoblot. Consequently, ?II-spectrin breakdown products (SBDPs) are potential biomarkers for diagnosing traumatic brain injury (TBI). The purpose of the following investigation, consisting of two studies, was to evaluate the utility of the spectrin biomarker in diagnosing TBI in fi sh that travel through hydroelectric dams in the Columbia and Snake Rivers. The fi rst study used hyperbaric pressure chambers to simulate the pressure changes that affect fi sh during passage through a Federal Columbia River Power System (FCRPS) Kaplan turbine. The second study tested the effect of a removable spillway weir (RSW) on the passage of juvenile chinook (Oncorhynchus tshawytscha). This study was conducted in tandem with a balloon-tag study by the U.S. Army Corps of Engineers. Brain samples from fi sh were collected and analyzed using an immunoblot for SBDPs, and imaging software was used to quantify the protein band density and determine the ratio of cleaved protein to total protein. The biomarker analyses found higher SBDP expression levels in fi sh that were exposed to lower pressure nadirs and fi sh that passed through the RSW at a deep orientation. In general, the incidence of injuries observed after treatment positively correlated with expression levels, suggesting that the biomarker method of analysis is comparable to traditional methods of injury assessment. It was also found that, for some treatments, the 110 kDa spectrin fragment (SBDP 110) correlated more strongly with necrotic head injury incidence and mortality rates than did the total cleaved protein or the 120 kDa fragment. These studies will be informative in future decisions regarding the design of turbines and fi sh passage structures in hydroelectric dams and will hopefully contribute to the development of faster and more accurate techniques for diagnosing TBI in fi sh.

Jonason, C.; Miracle, A.

2009-01-01T23:59:59.000Z

86

The Inverting Effect of Curvature in Winter Terrain Park Jump Takeoffs J. A. McNeil  

E-Print Network (OSTI)

Ackery, et al. [6] found evidence of an increasing incidence of traumatic brain injury and spinal cord

87

His brain, her brain?  

Science Journals Connector (OSTI)

His brain, her brain? 10.1126/science.1262061 Cordelia Fine Melbourne School of Psychological...scientific inquiry about what role biological sex plays in differences between brain function in human males and females. Greater knowledge of the influence...

Cordelia Fine

2014-11-21T23:59:59.000Z

88

Endovascular Treatment of Blunt Traumatic Abdominal Aortic Occlusion With Kissing Stent Placement  

SciTech Connect

Blunt traumatic abdominal aortic dissection is extremely rare and potentially deadly. We present the case of a 62-year-old man involved in a frontal car crash. After emergency undergoing laparotomy for bowel injuries, he was referred to our hospital due to acute ischemia of bilateral lower extremities on day 3 after the trauma. Computed tomography and aortography showed an aortobiiliac dissection with complete occlusion. This injury was successfully treated by endovascular treatment with 'kissing'-technique stent placement, which appears to be a safe, effective, and minimally invasive treatment.

Idoguchi, Koji, E-mail: idoguchi@ares.eonet.ne.jp; Yamaguchi, Masato; Okada, Takuya [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan); Nomura, Yoshikatsu [Kobe University Hospital, Department of Cardiovascular Surgery (Japan); Sugimura, Kazuro [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan); Okita, Yutaka [Kobe University Hospital, Department of Cardiovascular Surgery (Japan); Sugimoto, Koji [Kobe University Hospital, Department of Radiology and Center for Endovascular Therapy (Japan)

2012-10-15T23:59:59.000Z

89

Brain Imaging Findings in Neuropathic Pain  

E-Print Network (OSTI)

Brain Imaging Findings in Neuropathic Pain Paul Y. Geha, MD and A. Vania Apkarian, PhD* Address (posther- petic neuralgia), then the spinal cord (postspinal cord injury pain), to the brain itself mechanisms; hence, they assume implicitly or explicitly that the rest of the brain passively responds

Apkarian, A. Vania

90

Material-modeling and structural-mechanics aspects  

E-Print Network (OSTI)

Material-modeling and structural-mechanics aspects of the traumatic brain injury problem M for causing traumatic brain injury. Design/methodology/approach ­ Two levels of blast peak overpressure were computational investigation of impact on a human skull/brain assembly. Keywords Brain, Injuries, Modeling

Grujicic, Mica

91

Center For Brain Science 9/21/12 CENTER FOR BRAIN SCIENCE NEUROIMAGING  

E-Print Network (OSTI)

that involves serious #12;Center For Brain Science 9/21/12 2 personal injury. Sudden loss of the magnetic fieldCenter For Brain Science 9/21/12 1 CENTER FOR BRAIN SCIENCE NEUROIMAGING EMERGENCY PROCEDURES: If an individual is restrained or pinned to the magnet by a ferrous object, you must assess if the situation

Datta, Sandeep Robert

92

Intracranial Pressure Increases during Exposure to a Shock Wave  

E-Print Network (OSTI)

and Afghanistan. The extent of a blast TBI, especially initially, is difficult to diagnose, as internal injuries pressure; overpressure; traumatic brain injury Introduction Blast traumatic brain injuries (blast TBI of the mechanism of injury of TBI after exposure to blast. Substantial resources have been spent on the IED problem

VandeVord, Pamela

93

Original Contrbution Induction of oxidative and nitrosative damage leads to cerebrovascular  

E-Print Network (OSTI)

inflammation in an animal model of mild traumatic brain injury induced by primary blast P.M. Abdul) causes the development of mild traumatic brain injury (TBI) during a primary blast-wave spectrum.S. soldiers exposed to blast-wave pressure and combat experiences without any physical brain injury during

Farritor, Shane

94

www.elsevier.com/locate/jmbbm Available online at www.sciencedirect.com  

E-Print Network (OSTI)

compression Solid­fluid interaction Extracellular fluid Models of injury Permeability Rat brain a b s t r a c in the initial cause of mild traumatic brain injury (mTBI). Exposure to an external blast or to an impact may t The mechanical processes that underlie mild traumatic brain injury from physical insults are not well understood

Maryland at College Park, University of

95

Detection of Early Morning Daily Activities with Static Home and Wearable Wireless Nuri Firat Ince1, 2  

E-Print Network (OSTI)

or a penetrating injury to the head. In general, the frontal part of the brain is damaged in TBI cases. The frontal monitoring system for assisting patients with cognitive impairments due to traumatic brain injury (TBI tasks respectively. Keywords: Traumatic Brain Injury, Cognitively Impaired, Wearable Sensors, Wireless

Minnesota, University of

96

Ankle Injury TYPES OF ANKLE INJURIES  

E-Print Network (OSTI)

Ankle Injury TYPES OF ANKLE INJURIES: Ankle injuries can be acute or chronic in nature. Inverting (turning in) of the ankle, accounts for most acute injuries. Damage occurs when ankle is twisted or moved beyond its normal range. Overuse of the ankle can cause tearing of the ligaments or strain tendon fibers

Virginia Tech

97

Chapter 33 - Brain Embolism  

Science Journals Connector (OSTI)

Publisher Summary This chapter presents a discussion on the clinical findings of the brain embolism and cerebrovascular disorders. Brain embolism occurs when material, usually a thrombus, formed or introduced in one part of the vascular system travels to an artery that supplies brain tissue. There are three main components—the recipient artery that receives the material, the embolic material itself, and the donor source where the material originated. Donor sources include the heart, the aorta, and the neck arteries and their intracranial arterial branches proximal to the recipient artery. The most common cardiac sources are atrial fibrillation and other atrial arrythmias, myocardial ischemic pathology, and valvular heart diseases. However, less common cardiac pathologies such as myocardiopathies, cardiac tumors, and septal defects within the heart can also lead to brain embolism. The most common disease of arteries that leads to embolism is atherosclerosis. Materials from plaques and thrombi form within arteries in the neck and proximal intracranial arteries and embolize distally. Occasionally tumor particles, fat, and air and foreign particles introduced into veins or arteries embolize to the brain. The discussion on diagnosis includes recipient artery-related finding and donor sources. The chapter discusses treatment of the acute event of brain embolism and states that the goals of treatment of the acute ischemic event are minimization of brain ischemic injury and reperfusion whenever possible.

Louis R. Caplan; Werner Hacke

2003-01-01T23:59:59.000Z

98

1 USNCTAM 2010 16th US National Congress of Theoretical and Applied Mechanics  

E-Print Network (OSTI)

2@unlnotes.unl.edu INTRODUCTION Blast induced traumatic brain injury (bTBI) is signature injury effectiveness of helmet in mitigating early time blast induced mild traumatic brain injury. METHODOLOGY Two is simulated. Our blast scenarios are simulated by first positioning the head model in an atmosphere of air

Farritor, Shane

99

On the Role of a Nonlinear Stress-Strain Relation in Brain Trauma  

E-Print Network (OSTI)

On the Role of a Nonlinear Stress-Strain Relation in Brain Trauma Igor Szczyrba School-strain relation (that leads to a stiffening of the brain matter under strain) influences the brain dynamics head using our generalization of the viscoelastic Kelvin-Voigt brain injury model that includes

Burtscher, Martin

100

Does ethanol decrease the GCS in TBI patients?.  

E-Print Network (OSTI)

??Background: 20-50% of patients with traumatic brain injury (TBI) are under the influence of ethanol at hospital admission. The Glasgow Coma Scale (GCS) is used… (more)

Gunstad, Per Ole Flaten

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Engineering in Action Engineering Challenge Camp  

E-Print Network (OSTI)

Cafeteria 9:00 a.m. Air Pressure Activity 211 ESB Dr. Fei Dai 10:00 a.m. Traumatic Brain Injury Detection G

Mohaghegh, Shahab

102

Biomechanics and Modeling in Mechanobiology  

E-Print Network (OSTI)

PAPER Mechanics of blast loading on the head models in the study of traumatic brain injury using.1007/s10237-012-0421-8 Mechanics of blast loading on the head models in the study of traumatic brain. To understand the interactions of blast waves on the head and brain and to identify the mech- anisms of injury

Farritor, Shane

103

First steps in using machine learning on fMRI data to predict intrusive memories of traumatic film footage  

Science Journals Connector (OSTI)

Abstract After psychological trauma, why do some only some parts of the traumatic event return as intrusive memories while others do not? Intrusive memories are key to cognitive behavioural treatment for post-traumatic stress disorder, and an aetiological understanding is warranted. We present here analyses using multivariate pattern analysis (MVPA) and a machine learning classifier to investigate whether peri-traumatic brain activation was able to predict later intrusive memories (i.e. before they had happened). To provide a methodological basis for understanding the context of the current results, we first show how functional magnetic resonance imaging (fMRI) during an experimental analogue of trauma (a trauma film) via a prospective event-related design was able to capture an individual's later intrusive memories. Results showed widespread increases in brain activation at encoding when viewing a scene in the scanner that would later return as an intrusive memory in the real world. These fMRI results were replicated in a second study. While traditional mass univariate regression analysis highlighted an association between brain processing and symptomatology, this is not the same as prediction. Using MVPA and a machine learning classifier, it was possible to predict later intrusive memories across participants with 68% accuracy, and within a participant with 97% accuracy; i.e. the classifier could identify out of multiple scenes those that would later return as an intrusive memory. We also report here brain networks key in intrusive memory prediction. MVPA opens the possibility of decoding brain activity to reconstruct idiosyncratic cognitive events with relevance to understanding and predicting mental health symptoms.

Ian A. Clark; Katherine E. Niehaus; Eugene P. Duff; Martina C. Di Simplicio; Gari D. Clifford; Stephen M. Smith; Clare E. Mackay; Mark W. Woolrich; Emily A. Holmes

2014-01-01T23:59:59.000Z

104

Targeted Therapy for Brain Metastases: Improving the Therapeutic Ratio  

Science Journals Connector (OSTI)

...vascular dementia for irradiated brain tumor patients. Memantine. Memantine, a novel agent, is an N-methyl-d-aspartate...N-methyl-d-aspartate receptor antagonists such as memantine may be neuroprotective and prevent neuronal injury...

Rakesh R. Patel and Minesh P. Mehta

2007-03-15T23:59:59.000Z

105

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain  

E-Print Network (OSTI)

Oxidative stress plays an important role in neuronal injuries caused by cerebral ischemia. It is well established that free iron increases significantly during ischemia and is responsible for oxidative damage in the brain. ...

Ding, Hui; Yan, Cai-Zhen; Shi, Honglian; Zhao, Ya-Shuo; Chang, Shi-Yang; Yu, Peng; Wu, Wen_Shuang; Zhao, Chen-Yang; Chang, Yan-Zhong; Duan, Xiang-Lin

2011-09-21T23:59:59.000Z

106

International Journal of Applied Mechanics Vol. 3, No. 4 (2011) 803823  

E-Print Network (OSTI)

the blast-induced brain injury. Keywords: Brain; hyper-viscoelastic material model; high frequency; finite of the brain under blast loading conditions. An appropriate material model of the brain is essential to predict strain; blast wave. 1. Introduction Complete understanding of mild traumatic brain injuries (TBI) induced

Farritor, Shane

107

Computational Modeling of Human Head Under Blast Shailesh Ganpule, Dr. Linxia Gu, Dr. Guoxin Cao, Dr.Namas Chandra  

E-Print Network (OSTI)

Computational Modeling of Human Head Under Blast Loading Shailesh Ganpule, Dr. Linxia Gu, Dr;Presentation Objective: To understand role of helmet in blast induced Traumatic Brain Injury (TBI: To understand underlying mechanisms of blast induced Traumatic Brain Injury (TBI) and develop mitigation

Farritor, Shane

108

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure  

Science Journals Connector (OSTI)

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure ... The human brain is a uniquely complex organ, which has evolved a sophisticated protection system to prevent injury from external insults and toxins. ... Designing molecules that can overcome this protection system and achieve optimal concentration at the desired therapeutic target in the brain is a specific and major challenge for medicinal chemists working in CNS drug discovery. ...

Zoran Rankovic

2014-12-11T23:59:59.000Z

109

Head Rotational Acceleration Characteristics Influence Behavioral and Diffusion Tensor Imaging Outcomes Following Concussion  

Science Journals Connector (OSTI)

A majority of traumatic brain injuries (TBI) in motor vehicle crashes ... and caused by high-rate acceleration of the head. For injuries caused by rotational acceleration, ... Ninety-two Sprague–Dawley rats were ...

Brian D. Stemper; Alok S. Shah; Frank A. Pintar…

2014-10-01T23:59:59.000Z

110

Relative brain displacement and deformation during constrained mild frontal head impact  

Science Journals Connector (OSTI)

...of Mechanical, Aerospace and Structural...Department of Computer Science and Engineering...particles. In a more recent analysis of this...I. King 2001 Recent advances in brain injury research...of Mechanical, Aerospace and Structural...

2010-01-01T23:59:59.000Z

111

Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering  

E-Print Network (OSTI)

Recent advances in tissue engineering, combining an extracellular matrix (ECM)-like vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis ...

Bolliet, Catherine

2007-01-01T23:59:59.000Z

112

Vortices in Brain waves  

E-Print Network (OSTI)

2003). Vortices in Brain Waves 62. M. E. Raichle, ScienceVORTICES IN BRAIN WAVES WALTER J. FREEMAN Department ofthat is recorded in brain waves (electroencephalogram, EEG).

Freeman, Walter J III; Vitiello, Giuseppe

2010-01-01T23:59:59.000Z

113

Brain Abscess  

Science Journals Connector (OSTI)

To the Editor: In their review article, Brouwer et al. (July 31 issue) suggest the use of vancomycin for the treatment of brain abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA). However, regarding this choice, there are some concerns that should be considered. First, vancomycin... To the Editor: In their review article, Brouwer et al. (July 31 issue)1 suggest the use of vancomycin for the treatment of brain abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA). However, regarding this choice, there are some ...

2014-10-30T23:59:59.000Z

114

Combat-related blast injuries : injury types and outcomes  

E-Print Network (OSTI)

blast and PTSD diagnosis as covariates. The interaction of PTSD and injury severity was initially assessed prior to model

Eskridge, Susan Lindsay

2011-01-01T23:59:59.000Z

115

Adding ethylene to injury  

Science Journals Connector (OSTI)

... such as drought. On page 417 of this issue, Mehlhorn and Wellburn propose that ethylene, known to be emitted from stressed plants, determines the susceptibility of plants to injury ... , this could be an important unifying concept for explaining ozone/stress interactions.

Mike Unsworth

1987-06-04T23:59:59.000Z

116

D E P A R T M E N T O F M E C H A N I C A L E N G I N E E R I N G A . J A M E S C L A R K S C H O O L O F E N G I N E E R I N G  

E-Print Network (OSTI)

NEURO-IMAGING, MODELING, SIMULATION AND EXPERIMENTAL VALIDATION OF BLAST RELATED TRAUMATIC BRAIN INJURY.cecd.umd.edu #12;1 FOREWORD Blast-associated brain trauma is the signature injury of the Iraq and Afghanistan wars (TBI). The most common cause of these catastrophic injuries has been exposure to blasts associated

Maryland at College Park, University of

117

Child Abuse; Head Injuries  

Science Journals Connector (OSTI)

Abstract Abusive head trauma produces the most long-term morbidity and mortality of all forms of child physical abuse and impacts up to 30 infants per 100 000 births. A great deal of the scientific and lay press has focused on the changes in understanding and the purported controversies surrounding this entity. At the same time, the evidence base for a probabilistic analysis of head injuries and related trauma promises to make the diagnosis more objective, nuanced, and accurate.

S.C. Boos

2014-01-01T23:59:59.000Z

118

Bicycle helmets are highly effective at preventing head injury during head impact: Head-form accelerations and injury criteria for helmeted and unhelmeted impacts  

Science Journals Connector (OSTI)

Abstract Cycling is a popular form of recreation and method of commuting with clear health benefits. However, cycling is not without risk. In Canada, cycling injuries are more common than in any other summer sport; and according to the US National Highway and Traffic Safety Administration, 52,000 cyclists were injured in the US in 2010. Head injuries account for approximately two-thirds of hospital admissions and three-quarters of fatal injuries among injured cyclists. In many jurisdictions and across all age levels, helmets have been adopted to mitigate risk of serious head injuries among cyclists and the majority of epidemiological literature suggests that helmets effectively reduce risk of injury. Critics have raised questions over the actual efficacy of helmets by pointing to weaknesses in existing helmet epidemiology including selection bias and lack of appropriate control for the type of impact sustained by the cyclist and the severity of the head impact. These criticisms demonstrate the difficulty in conducting epidemiology studies that will be regarded as definitive and the need for complementary biomechanical studies where confounding factors can be adequately controlled. In the bicycle helmet context, there is a paucity of biomechanical data comparing helmeted to unhelmeted head impacts and, to our knowledge, there is no data of this type available with contemporary helmets. In this research, our objective was to perform biomechanical testing of paired helmeted and unhelmeted head impacts using a validated anthropomorphic test headform and a range of drop heights between 0.5 m and 3.0 m, while measuring headform acceleration and Head Injury Criterion (HIC). In the 2 m (6.3 m/s) drops, the middle of our drop height range, the helmet reduced peak accelerations from 824 g (unhelmeted) to 181 g (helmeted) and HIC was reduced from 9667 (unhelmeted) to 1250 (helmeted). At realistic impact speeds of 5.4 m/s (1.5 m drop) and 6.3 m/s (2.0 m drop), bicycle helmets changed the probability of severe brain injury from extremely likely (99.9% risk at both 5.4 and 6.3 m/s) to unlikely (9.3% and 30.6% risk at 1.5 m and 2.0 m drops respectively). These biomechanical results for acceleration and HIC, and the corresponding results for reduced risk of severe brain injury show that contemporary bicycle helmets are highly effective at reducing head injury metrics and the risk for severe brain injury in head impacts characteristic of bicycle crashes.

Peter A. Cripton; Daniel M. Dressler; Cameron A. Stuart; Christopher R. Dennison; Darrin Richards

2014-01-01T23:59:59.000Z

119

WORKERS' COMPENSATION INJURY / INCIDENT REPORT  

E-Print Network (OSTI)

with appropriate medical care and a portion of lost wages following a work-related injury, illness or disease. MEDICAL TREATMENT In cases of job-related injury/illness, on-campus employees are required to obtain needed medical care either from Occupational Health Services at Poudre Valley Hospital, Concentra Medical

120

Human Functional Brain Imaging  

E-Print Network (OSTI)

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

Rambaut, Andrew

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Radial Glial Cell Line C6-R Integrates Preferentially in Adult White Matter and Facilitates Migration of Coimplanted Neurons in Vivo  

E-Print Network (OSTI)

larger volume than neurons alone or neurons coimplanted with fibro- blasts. In brains preinjured migration that may facilitate development of experimental models for neural trans- plantation cerebrovascular disease, degenerative dementias, cerebellar degeneration, and traumatic injuries of the head

Fischer, Itzhak

122

NNSA employees run to raise awareness about concussions | National...  

National Nuclear Security Administration (NNSA)

on behalf of the Derek Sheely Foundation. On Aug. 22, 2011, Derek suffered a traumatic brain injury during football practice at Frostburg State University and died one week later....

123

Vol 442|6 July 2006 RESEARCH HIGHLIGHTS  

E-Print Network (OSTI)

like light bulbs under a fluorescence microscope, allowing the researchers to track each protein a traumatic brain injury. Researchers led by Henning Voss of the Citigroup Biomedical Imaging Center and Weill

Robock, Alan

124

Nitric Oxide and Oxygen Radical Attack on GDP-Dissociation Inhibitor 2 (GDI-2) in Spinal Cord Injury of the Rat  

Science Journals Connector (OSTI)

Nitric Oxide and Oxygen Radical Attack on GDP-Dissociation Inhibitor 2 (GDI-2) in Spinal Cord Injury of the Rat ... Herein, mass spectrometry unambiguously identified GDP-dissociation inhibitor-2 (GDI-2) in SCI with post-translational modifications of 3-aminotyrosine (8 h post-injury) and an acrolein adduct of GDI-2 (72 h post-injury). ... Protein profiling in SCI of the rat revealed that, at 8 h following the traumatic lesion, levels of a signalling protein, GDP-dissociation inhibitor-2 protein (GDI-2) (synonym:? Rab GDP dissociation inhibitor beta), were increased about 3-fold, and we therefore decided to use this potentially important signalling structure to study the presence of oxidation- and nitration-induced PTMs in SCI. ...

Julius Paul Pradeep John; Oliver Pintsov; Alexander Petter-Puchner; Heinz Redl; Arnold Pollak; Wei-Qiang Chen; Gert Lubec

2007-02-22T23:59:59.000Z

125

Illness and Injury Surveillance Program (IISP) Reports  

Energy.gov (U.S. Department of Energy (DOE))

A full list of Special Illness and Injury Surveillance and Annual Reports are available upon request.

126

Optogenetic Brain Interfaces  

E-Print Network (OSTI)

The brain is a large network of interconnected neurons where each cell functions as a nonlinear processing element. Unraveling the mysteries of information processing in the complex networks of the brain requires versatile ...

Pashaie, Ramin

127

Mechanisms of brain ventricle development  

E-Print Network (OSTI)

The brain ventricles are a conserved system of fluid-filled cavities within the brain that form during the earliest stages of brain development. Abnormal brain ventricle development has been correlated with neurodevelopmental ...

Lowery, Laura Anne

2008-01-01T23:59:59.000Z

128

NAVIGATING THE BRAIN'S MYSTERIES  

E-Print Network (OSTI)

C C C A A A A G A G G D D D D D F D F F F H H H E E E E FHE E B B B C E B NAVIGATING THE BRAIN of the brain-- one that shows its complex trafficking across trillions of neuronal connections. Addressing: outlining "the next great American project," the BRAIN (Brain Research through Advancing Innovative

129

Human Functional Brain Imaging  

E-Print Network (OSTI)

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

Rambaut, Andrew

130

Blast-Induced Biomechanical Loading of the Rat: An Experimental and Anatomically Accurate  

E-Print Network (OSTI)

Computational Blast Injury Model Aravind Sundaramurthy, Aaron Alai, Shailesh Ganpule, Aaron Holmberg, Erwan head injuries. This has led to an increased number of blast studies of animal models, head surrogates traumatic brain injury (TBI) in soldiers and civilians. In vivo animal models that use shock tubes

Farritor, Shane

131

Blast-induced phenotypic switching in cerebral vasospasm  

E-Print Network (OSTI)

of the cerebrovasculature is a common manifestation of blast-induced traumatic brain injury (bTBI) reported among combat is not required for vasospasm in bTBI, which suggests that the unique mechanics of blast injury could potentiate. These results suggest that an acute, blast-like injury is sufficient to induce a hypercontraction

Parker, Kevin Kit

132

(This is a sample cover image for this issue. The actual cover is not yet available at this time.) This article appeared in a journal published by Elsevier. The attached  

E-Print Network (OSTI)

An in vitro injury model for SH-SY5Y neuroblastoma cells: Effect of strain and strain rate Maciej Skotak, Fang injury model wherein a wide range of strain () and strain rate ( ) can be precisely and independently encounter during either blunt or blast impact-induced traumatic brain injuries (TBIs). In combination

Farritor, Shane

133

Epidemiology of Blunt Head Trauma in Children in U.S. Emergency Departments  

Science Journals Connector (OSTI)

To the Editor: Traumatic brain injury is the leading cause of death and disabilities in children older than 1 year of age. Detailed data about head trauma in children are needed to better understand the rates and unique age-related risks of injury. We examined the characteristics of children with blunt... Among more than 43,000 children treated in 25 emergency departments for blunt head trauma, traumatic brain injury was identified on CT scan in 7% of the patients. Falls were the most frequent injury mechanism for children under the age of 12 years.

2014-11-13T23:59:59.000Z

134

The Brain Basis of Emotions 1 BRAIN BASIS OF EMOTION  

E-Print Network (OSTI)

The Brain Basis of Emotions 1 BRAIN BASIS OF EMOTION The brain basis of emotion: A meta, Building 149 Charlestown, MA 02129 lindqukr@nmr.mgh.harvard.edu #12;The Brain Basis of Emotions 2 Abstract Researchers have wondered how the brain creates emotions since the early days of psychological science

Barrett, Lisa Feldman

135

Predicting Quality of Life Five Years Following Medical Discharge for a Traumatically-Acquired Spinal Cord Injury  

E-Print Network (OSTI)

following disability. Two models were examined in order to predict QoL, Model 1 (Life Satisfaction) and Model 2 (Self-Perceived Health Status). Results from this study were obtained by testing models using path modeling. Evaluation indices suggest good...

Erosa, Norma

2012-10-19T23:59:59.000Z

136

The Brain's Inner Workings  

E-Print Network (OSTI)

The Architecture of the Brain ......................................................................... 18 Activity to one another. Even single-celled organisms can respond to envir They can also coordinate

Bandettini, Peter A.

137

UniversityofFlorida/CollegeofPharmacySpring/Summer2004 Research Focus on Safety & Efficacy  

E-Print Network (OSTI)

in specific institutions · Enhancing patient safety · Mechanisms within the brain responsible for feeding of stroke, traumatic brain injury, depression and drug addiction · Effects of drugs on patient quality · Non-viral gene therapy for brain cancer · Pharmaco-epidemiologic methods to evaluate the effectiveness

Roy, Subrata

138

Adaptive Personalisation for Researcher-Independent  

E-Print Network (OSTI)

Adaptive Personalisation for Researcher-Independent Brain-Body Interface Usage Abstract In this case study, we report what we believe to be the first prolonged in-situ use of a brain-body interface for rehabilitation of individuals with severe neurological impairment due to traumatic brain injury

Boetticher, Gary D.

139

Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review  

Science Journals Connector (OSTI)

...December 2014 review-article Reviews Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review Kimberly J...University, Palo Alto, California. Childhood brain tumors are the most common pediatric solid tumor...

Kimberly J. Johnson; Jennifer Cullen; Jill S. Barnholtz-Sloan; Quinn T. Ostrom; Chelsea E. Langer; Michelle C. Turner; Roberta McKean-Cowdin; James L. Fisher; Philip J. Lupo; Sonia Partap; Judith A. Schwartzbaum; Michael E. Scheurer

2014-12-01T23:59:59.000Z

140

International Human Capital Formation, Brain Drain and Brain  

E-Print Network (OSTI)

systems, individuals' abilities, sunk educational investment costs, government grants, and expected capital formation, brain gain, brain drain, international migration, sunk costs, educational grants

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Spatiotemporal brain imaging and modeling  

E-Print Network (OSTI)

This thesis integrates hardware development, data analysis, and mathematical modeling to facilitate our understanding of brain cognition. Exploration of these brain mechanisms requires both structural and functional knowledge ...

Lin, Fa-Hsuan, 1972-

2004-01-01T23:59:59.000Z

142

Brain reorganization, not relative brain size, primarily characterizes anthropoid brain evolution  

Science Journals Connector (OSTI)

...reserved. May 22, 2013 research-article Research articles 1001 42 70 133 Brain reorganization, not relative brain size, primarily characterizes anthropoid brain evolution J. B. Smaers 1 2 C. Soligo 1 e-mail: j.smaers@ucl.ac...

2013-01-01T23:59:59.000Z

143

The lived experience of post-traumatic stress disorder as described by motor vehicle accident victims in Jordan.  

E-Print Network (OSTI)

??Aim: To explore the lived experience of post-traumatic stress disorder (PTSD) as described by individuals who have been involved in a motor vehicle accident (MVA)… (more)

Al-Kofahy, Lilibeth

2011-01-01T23:59:59.000Z

144

Brain Penetrant LRRK2 Inhibitor  

Science Journals Connector (OSTI)

Brain Penetrant LRRK2 Inhibitor ... ?M in cells and is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse brain following intraperitoneal delivery of doses as low as 50 mg/kg. ... LRRK2; blood?brain barrier; brain penetrant inhibitor; 2,4-diaminopyrimidine ...

Hwan Geun Choi; Jinwei Zhang; Xianming Deng; John M. Hatcher; Matthew P. Patricelli; Zheng Zhao; Dario R. Alessi; Nathanael S. Gray

2012-06-18T23:59:59.000Z

145

Solar radiation induces sublethal injury in Escherichia coli in seawater.  

Science Journals Connector (OSTI)

...after cells were exposed to solar radiation. Injury was detected...030670-05$02.00/0 Solar Radiation Induces Sublethal...Harvard University, Cambridge, Massachusetts 02138 Sublethal injury was...after cells were exposed to solar radiation. Injury was detected...

R B Kapuscinski; R Mitchell

1981-03-01T23:59:59.000Z

146

PIA - Richland Occupational Injury and Illness | Department of...  

Energy Savers (EERE)

Injury and Illness More Documents & Publications Occupational Injury & Illness System (01&15) PIA, Idaho National Laboratory PIA - Bonneville Power Adminstration Ethics Helpline...

147

The Brain: This Is Your Brain On... | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

The Brain: This Is Your Brain On... October 19, 2014 12:00PM to 1:30PM Presenter Kayt Sukel, Carl Hart, Deepak Chopra, Lynn Rogers, Patricia Smith Churchland, Daniel Levitin,...

148

for the brain SPRING 2012  

E-Print Network (OSTI)

Plug-ins for the brain SPRING · 2012 NATURE'S SOLARCELLS Learning from diatoms · 28 HANNIBAL'S HEAD

Malinnikova, Eugenia

149

Methods for assisting recovery of damaged brain and spinal cord using arrays of X-Ray microplanar beams  

DOE Patents (OSTI)

A method of assisting recovery of an injury site of brain or spinal cord injury includes providing a therapeutic dose of X-ray radiation to the injury site through an array of parallel microplanar beams. The dose at least temporarily removes regeneration inhibitors from the irradiated regions. Substantially unirradiated cells surviving between the microplanar beams migrate to the in-beam irradiated portion and assist in recovery. The dose may be administered in dose fractions over several sessions, separated in time, using angle-variable intersecting microbeam arrays (AVIMA). Additional doses may be administered by varying the orientation of the microplanar beams. The method may be enhanced by injecting stem cells into the injury site.

Dilmanian, F. Avraham (Yaphank, NY); McDonald, III, John W. (Baltimore, MD)

2007-12-04T23:59:59.000Z

150

Reverse engineering the human brain  

Science Journals Connector (OSTI)

...Thompson Reverse engineering the human brain Vincent Walsh Department of Experimental...can be used to temporarily prevent the brain from carrying out some of its normal functions...outline some of the advances in understanding brain function made by using TMS, and, in particular...

2000-01-01T23:59:59.000Z

151

Complex Systems and Brain Sciences  

E-Print Network (OSTI)

Center for Complex Systems and Brain Sciences Charles E. Schmidt College of Science www.ccs.fau.edu #12;Center for Complex Systems and Brain Sciences Our Mission The mission of the Center for Complex Systems and Brain Sciences is to understand the principles and mechanisms underlying complex behavior

Fernandez, Eduardo

152

Escaping Out of the Brain  

Science Journals Connector (OSTI)

...article-commentary In the Spotlight Escaping Out of the Brain Joan Seoane 1 2 3 * Leticia De Mattos-Arruda...inability of tumor cells to escape from the brain. CTCs have been studied in other malignancies...from fresh GBM surgical specimens into the brains of immunocompromised mice (3). Patient-derived...

Joan Seoane and Leticia De Mattos-Arruda

2014-11-01T23:59:59.000Z

153

Uses and challenges of bioinformatic tools in mass spectrometric-based proteomic brain perturbation studies  

Science Journals Connector (OSTI)

Mass spectrometry (MS) has become the method of choice to study the proteome of brain injury. The high throughput nature of MS-based proteomic experiments generates massive amount of mass spectral data presenting great challenges in downstream interpretation. Currently, different bioinformatics platforms are available for functional analysis and data mining of MS-generated proteomic data. These tools provide a way to convert data sets to biologically interpretable results and functional outcomes. In this review, a brief overview of the currently available bioinformatics strategies applied to neuroproteomic studies is presented. Application of commercially available bioinformatics software to different brain injury studies demonstrates integration of the data mining and analysis applications into neuroproteomic workflows that can identify major protein markers as well as highlight the biological processes and molecular functions involved.

Joy D. Guingab-Cagmat; Emilio B. Cagmat; Firas H. Kobeissy; John Anagli

2014-01-01T23:59:59.000Z

154

Functional photoacoustic tomography of animal brains  

E-Print Network (OSTI)

-animal Brains in situ............................................................ 13 3.1 Photoacoustic imaging of mouse brains in situ................................... 13 3.2 Photoacoustic imaging of rat brains in situ............................................ 14 3.3 Photoacoustic imaging of rat brain lesions ......................................... 15 3.4 Photoacoustic imaging of rat brain tumors ......................................... 17 3.5 3-D imaging of mouse brains in situ...

Wang, Xueding

2005-11-01T23:59:59.000Z

155

Investigation of nerve injury through microfluidic devices  

Science Journals Connector (OSTI)

...compartments with chemical reagents. Microfluidic platforms further facilitate...Microfluidic platforms can be broadly...devices that model chemical and physical...vivo setting. Chemical injury can be...microfluidic platform, whereas physical...

2014-01-01T23:59:59.000Z

156

Brain–computer symbiosis  

Science Journals Connector (OSTI)

The theoretical groundwork of the 1930s and 1940s and the technical advance of computers in the following decades provided the basis for dramatic increases in human efficiency. While computers continue to evolve, and we can still expect increasing benefits from their use, the interface between humans and computers has begun to present a serious impediment to full realization of the potential payoff. This paper is about the theoretical and practical possibility that direct communication between the brain and the computer can be used to overcome this impediment by improving or augmenting conventional forms of human communication. It is about the opportunity that the limitations of our body's input and output capacities can be overcome using direct interaction with the brain, and it discusses the assumptions, possible limitations and implications of a technology that I anticipate will be a major source of pervasive changes in the coming decades.

Gerwin Schalk

2008-01-01T23:59:59.000Z

157

How brains make decisions  

E-Print Network (OSTI)

This chapter, dedicated to the memory of Mino Freund, summarizes the Quantum Decision Theory (QDT) that we have developed in a series of publications since 2008. We formulate a general mathematical scheme of how decisions are taken, using the point of view of psychological and cognitive sciences, without touching physiological aspects. The basic principles of how intelligence acts are discussed. The human brain processes involved in decisions are argued to be principally different from straightforward computer operations. The difference lies in the conscious-subconscious duality of the decision making process and the role of emotions that compete with utility optimization. The most general approach for characterizing the process of decision making, taking into account the conscious-subconscious duality, uses the framework of functional analysis in Hilbert spaces, similarly to that used in the quantum theory of measurements. This does not imply that the brain is a quantum system, but just allows for the simple...

Yukalov, V I

2014-01-01T23:59:59.000Z

158

Risk factors for ankle sprain injury in male amateur soccer players: A prospective cohort study.  

E-Print Network (OSTI)

??Background: Ankle sprain injuries account for around 20% of all soccer injuries and more than 80% of all ankle injuries. Seventy four percent of the… (more)

Vereijken, A.J.

2012-01-01T23:59:59.000Z

159

Neutralizing anti-interleukin-1? antibodies modulate fetal blood–brain barrier function after ischemia  

Science Journals Connector (OSTI)

Abstract We have previously shown that increases in blood–brain barrier permeability represent an important component of ischemia–reperfusion related brain injury in the fetus. Pro-inflammatory cytokines could contribute to these abnormalities in blood–brain barrier function. We have generated pharmacological quantities of mouse anti-ovine interleukin-1? monoclonal antibody and shown that this antibody has very high sensitivity and specificity for interleukin-1? protein. This antibody also neutralizes the effects of interleukin-1? protein in vitro. In the current study, we hypothesized that the neutralizing anti-interleukin-1? monoclonal antibody attenuates ischemia–reperfusion related fetal blood–brain barrier dysfunction. Instrumented ovine fetuses at 127 days of gestation were studied after 30 min of carotid occlusion and 24 h of reperfusion. Groups were sham operated placebo-control- (n = 5), ischemia-placebo- (n = 6), ischemia-anti-IL-1? antibody- (n = 7), and sham-control antibody- (n = 2) treated animals. Systemic infusions of placebo (0.154 M NaCl) or anti-interleukin-1? monoclonal antibody (5.1 ± 0.6 mg/kg) were given intravenously to the same sham or ischemic group of fetuses at 15 min and 4 h after ischemia. Concentrations of interleukin-1? protein and anti-interleukin-1? monoclonal antibody were measured by ELISA in fetal plasma, cerebrospinal fluid, and parietal cerebral cortex. Blood–brain barrier permeability was quantified using the blood-to-brain transfer constant (Ki) with ?-aminoisobutyric acid in multiple brain regions. Interleukin-1? protein was also measured in parietal cerebral cortices and tight junction proteins in multiple brain regions by Western immunoblot. Cerebral cortical interleukin-1? protein increased (P brain anti-interleukin-1? monoclonal antibody levels were higher (P brain regions (P brain anti-interleukin-1? antibody uptake, and attenuate ischemia–reperfusion-related interleukin-1? protein up-regulation and increases in blood–brain barrier permeability across brain regions in the fetus. The pro-inflammatory cytokine, interleukin-1?, contributes to impaired blood–brain barrier function after ischemia in the fetus.

Xiaodi Chen; Grazyna B. Sadowska; Jiyong Zhang; Jeong-Eun Kim; Erin E. Cummings; Courtney A. Bodge; Yow-Pin Lim; Oleksandr Makeyev; Walter G. Besio; John Gaitanis; Steven W. Threlkeld; William A. Banks; Barbara S. Stonestreet

2015-01-01T23:59:59.000Z

160

Ethical issues in brain nanomedicine  

Science Journals Connector (OSTI)

Brain pathology is a perfect application field for nanotechnologies supporting the concept of nanomedicine. It implies the use of nanosized tools...

A. Bouamrani; L. Peletier; D. Ratel; J. P. Issartel; D. Wion…

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Holographic “Brain” Memory and Computation  

Science Journals Connector (OSTI)

Holography and information are tightly connected concepts. Holography has been used as a metaphore for the coding of information in the brain. We investigate holography inspired coding...

Dolev, Shlomi; Hanemann, Ariel

162

The development of EEG-based brain computer interfaces: potential and challenges  

Science Journals Connector (OSTI)

Brain computer interface (BCI) technology potentially opens the door to allowing our brain to influence the outside world without the use of muscles. This research concentrates on developing new augmentative communication and control technologies for those with severe neuromuscular disorders, such as stroke and spinal cord injury. Most BCIs decode the intent of the user from the brain's electrical activity as recorded from the scalp (electroencephalography, EEG). The EEG signal is very difficult to process, but many advances have been made to translate the signal into commands. At The University of Auckland, EEG-based BCIs have been under development for the past few years. Our laboratory has produced excellent results including an EEG controlled video game, an EEG phone dialing system, and an EEG active rehabilitation exercise. Research is ongoing in this area, with new projects starting for control of prostheses or rehabilitation robots in clinical trials.

Song Xing; Ryan McCardle; Shane Xie

2014-01-01T23:59:59.000Z

163

Injury experience in stone mining, 1992  

SciTech Connect

This Mine Safety and Health Administration (MSHA) informational report reviews in detail the occupational injury and illness experience of stone mining in the United States for 1992. Data reported by operators of mining establishments concerning work injuries are summarized by work location, accident classification, part of body injured, nature of injury, occupation, and principal type of mineral. Related information on employment, worktime, and operating activity also is presented. Data reported by independent contractors performing certain work at mining locations are depicted separately in this report. For ease of comparison with other metal and nonmetallic mineral mining industries and with coal mining, summary reference tabulations are included at the end of both the operator and the contractor sections of this report.

Not Available

1994-05-01T23:59:59.000Z

164

brain control of coughing  

E-Print Network (OSTI)

There is an overwhelming body of evidence to support the existence of higher brain circuitries involved in the sensory detection of airways irritation and the motor control of coughing. The concept that cough is purely a reflex response to airways irritation is now superseded by the recognition that perception of an urge-to-cough and altered behavioral modification of coughing are key elements of cough disorders associated with airways disease. Understanding the pathways by which airway sensory nerves ascend into the brain and the patterns of neural activation associated with airways irritation will undoubtedly provide new insights into disordered coughing. This brief review aims to explore our current understanding of higher order cough networks by summarizing data from recent neuroanatomical and functional studies in animals and humans. We provide evidence for the existence of distinct higher order network components involved in the discrimination of signals arising from the airways and the motor control of coughing. The identification of these network components provides a blueprint for future research and the development of targeted managements for cough and the urge-to-cough. John Widdicombe remembered In 2002, while holidaying in London, I (SBM) received a pleasant email invitation to join John and his wife

Stuart B Mazzone; Alice E Mcgovern; Seung-kwon Yang; Ariel Woo; Ayaka Ando; Jennifer Leech; Michael J Farrell

165

Homological scaffolds of brain functional networks  

Science Journals Connector (OSTI)

...are credited. Homological scaffolds of brain functional networks G. Petri 1 P. Expert...Clinical Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London...study the characteristics of functional brain networks at the mesoscopic level from a...

2014-01-01T23:59:59.000Z

166

Brain Tissue: A Viable Postmortem Toxicological Specimen  

Science Journals Connector (OSTI)

......research-article Short Communication Brain Tissue: A Viable Postmortem Toxicological...Minneapolis, Wichita, KS 67214, USA Brain tissue may be a valuable specimen in interpretation...protected and isolated position of the brain eliminates or at least attenuates many......

Timothy P. Rohrig; Charity A. Hicks

2014-12-01T23:59:59.000Z

167

Brain MRI Classification using the Expectation Maximization  

E-Print Network (OSTI)

Brain MRI Classification using the Expectation Maximization made a brain magnetic resonance image (MRI) classification algorithm that uses a twostage applied to a set of normal brain MR images for further testing. We accomplished a working

Chen, Tsuhan

168

Type B Accident Investigation Board Report on the Head Injury...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

on the Head Injury to a Miner at the Waste Isolation Pilot Plant, Carlsbad, New Mexico - August 25, 2004 Type B Accident Investigation Board Report on the Head Injury to a Miner at...

169

Solar Brain Srl | Open Energy Information  

Open Energy Info (EERE)

Brain Srl Jump to: navigation, search Name: Solar Brain Srl Place: Rome, Italy Zip: 189 Sector: Solar Product: Rome-based solar and alternative energy company. References: Solar...

170

To: Supervisors and Managers Subject: Computer-Related Ergonomic Injuries  

E-Print Network (OSTI)

To: Supervisors and Managers Subject: Computer-Related Ergonomic Injuries Date: March 14, 2007 The statistics we have collected at the Lab this year are disturbing to me in the area of ergonomic injuries from-blown injuries. Over the next seven days, all supervisors must meet with their employees, discuss good ergonomic

Knowles, David William

171

Ankle Injuries Approved by the UHS Patient Education Committee  

E-Print Network (OSTI)

Ankle Injuries Approved by the UHS Patient Education Committee Revised 01/11/12 Page 1 of 2 There are several types of ankle injuries, some serious enough to require many months of healing and others that can heal within a few weeks. Types of Ankle Injuries Ankle Sprain: Caused by stretching or tearing of one

172

Ankle Injuries Approved by the UHS Patient Education Committee  

E-Print Network (OSTI)

Ankle Injuries Approved by the UHS Patient Education Committee Revised 02/12/14 Page 1 of 2 There are several types of ankle injuries, some serious enough to require many months of healing and others that can heal within a few weeks. Types of Ankle Injuries Ankle Sprain: Caused by stretching or tearing of one

Yener, Aylin

173

Injury experience in coal mining, 1991  

SciTech Connect

This Mine Safety and Health Administration (MSHA) informational report reviews in detail the occupational injury and illness experience of coal mining in the United States for 1991. Data reported by operators of mining establishments concerning work injuries are summarized by work location, accident classification, part of body injured, nature of injury, occupation, and anthracite or bituminous coal. Related information on employment, worktime, and operating activity also is presented. Data reported by independent contractors performing certain work at mining locations are depicted separately in this report. For ease of comparison between coal mining and the metal and nonmetal mineral mining industries, summary reference tabulations are included at the end of both the operator and the contractor sections of this report. Data used in compiling this report were reported by operators of coal mines and preparation plants on a mandatory basis as required under the Federal Mine Safety and Health Act of 1977, Public Law 91-173,as amended by Public Law 95-164. Since January 1, 1978, operators of mines or preparation plants or both which are subject to the Act have been required under 30 CFR, Part 50, to submit reports of injuries, occupational illnesses, and related data.

Not Available

1991-12-31T23:59:59.000Z

174

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury  

E-Print Network (OSTI)

magnetic resonance imaging (MRI) with a temporal resolution of 30 mins was performed on permanent. With permanent ischemia (n ÂĽ 11), forepaw stimulation fMRI response in the primary somatosensory cortices was lost, although vascular coupling (CO2 response) was intact in some animals. Control experiments

Duong, Timothy Q.

175

Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury  

E-Print Network (OSTI)

and Astronomy and Department of Radiology 209 South 33rd Street Philadelphia, Pennsylvania 19104 and ICFO corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients

Yodh, Arjun G.

176

Optical Coherence Imaging of Hemodynamics, Metabolism, and Cell Viability during Brain Injury  

Science Journals Connector (OSTI)

Pre-clinical quantitative imaging endpoints have been challenging in mouse models of cerebrovascular disease. Here we present optical coherence imaging platforms that can quantify...

Srinivasan, Vivek J; Chong, Shau Poh; Merkle, Conrad; Radhakrishnan, Harsha; Leahy, Conor

177

Environment/Health/Safety (EHS): Performing Injury Investigations  

NLE Websites -- All DOE Office Websites (Extended Search)

Injury Review & Analysis Injury Review & Analysis Investigation Team Roles Data Gathering Personnel Time Space Activity Hazards Work Authorizations Equipment Human Factors Slips, Trips, & Falls Ergonomics ISM Analysis Core Func./Guiding Princ. ISM Builder Examples Corrective Action Dev. CHESS Login CHESS User's Manual Accident Statistics Occupational Injury and Illness Review Paul Alivisatos photo Lab Director Paul Alivisatos shares guiding principles to be used during incident anlayses. This tutorial introduces the LBNL Injury Review Program and provides a 'toolkit' that to help you in the injury review process. The tool kit includes tools for data gathering, ISM analysis, and corrective action development. LBNL employees must report report all work-related injuries or illnesses to their supervisor and Health Services. A work-related injury (or

178

February 8, 2006 Brain Science Institute  

E-Print Network (OSTI)

February 8, 2006 Brain Science Institute Critical Period Mechanisms Research Group Laboratory the Brain Pliable Mammals have "pliable" brain functions such as "learning", "memory", "recognition", "emotion" and "decision-making". These higher-order brain functions are apparently maintained by means

Kazama, Hokto

179

BrainPrint : Identifying Subjects by their Brain Christian Wachinger1,2  

E-Print Network (OSTI)

BrainPrint : Identifying Subjects by their Brain Christian Wachinger1,2 , Polina Golland1 , Martin, Harvard Medical School Abstract. Introducing BrainPrint, a compact and discriminative rep- resentation of anatomical structures in the brain. BrainPrint captures shape information of an ensemble of cortical

Golland, Polina

180

Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil  

Science Journals Connector (OSTI)

Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil ... The blood brain barrier (BBB) represents the biggest challenge for therapeutic drugs to enter the brain. ... In our study, we selected chlorambucil (CHL), an alkylating agent, as the model therapeutic agent, and used scopine as a novel brain-targeting moiety. ...

Xinyi Wang; Jianbo Li; Chaoqun Xu; Yanping Li; Tao Gong; Xun Sun; Yao Fu; Qin He; Zhirong Zhang

2014-10-28T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

BrainKnowledge: A Human Brain Function Mapping Knowledge-Base System  

E-Print Network (OSTI)

BrainKnowledge: A Human Brain Function Mapping Knowledge-Base System Mei-Yu Hsiao & Chien and interpretation of fMRI data. Here, we present a human brain function mapping knowledge-base system (BrainKnowledge) that associates fMRI data analysis and literature search func- tions. BrainKnowledge not only contains indexed

Chen, Chein Chung

182

Brain imaging methods used in experimental brain research such as Positron Emission Tomography (PET) and Functional  

E-Print Network (OSTI)

ABSTRACT Brain imaging methods used in experimental brain research such as Positron Emission and are best understood in the context of the underlying 3D brain anatomy. In this paper, we present a novel Brain Mapping, Functional Imaging 1 INTRODUCTION Although the human brain is no longer the black box

Mueller, Klaus

183

Methods for functional brain imaging  

E-Print Network (OSTI)

Magnetic resonance imaging (MRI) has demonstrated the potential for non-invasive mapping of structure and function (fMRI) in the human brain. In this thesis, we propose a series of methodological developments towards ...

Witzel, Thomas, Ph. D. Massachusetts Institute of Technology

2011-01-01T23:59:59.000Z

184

Brain Imaging with Positron Emission Tomography: Quantification and Biomedical Applications in Alzheimer's Disease and Brain Tumors  

E-Print Network (OSTI)

AB, Elson LM. The human brain coloring book. 1st ed. New21. Toga AW, Mazziotta JC. Brain mapping : the systems. SanSR, Phelps ME. Imaging Brain Function with Positron Emission

Wardak, Mirwais

2013-01-01T23:59:59.000Z

185

Role of blood-brain barrier leakage during stroke  

E-Print Network (OSTI)

injury during ischemia. Stroke, 2010. Permission wasand surrounding tissue injury. Stroke. 2009 Dec;40(12):e666-surrounding tissue injury. Stroke. 2009;40:e666-674 Lo EH. A

Chen, Bo

2010-01-01T23:59:59.000Z

186

Radiation Dose-Volume Effects in the Brain  

SciTech Connect

We have reviewed the published data regarding radiotherapy (RT)-induced brain injury. Radiation necrosis appears a median of 1-2 years after RT; however, cognitive decline develops over many years. The incidence and severity is dose and volume dependent and can also be increased by chemotherapy, age, diabetes, and spatial factors. For fractionated RT with a fraction size of <2.5 Gy, an incidence of radiation necrosis of 5% and 10% is predicted to occur at a biologically effective dose of 120 Gy (range, 100-140) and 150 Gy (range, 140-170), respectively. For twice-daily fractionation, a steep increase in toxicity appears to occur when the biologically effective dose is >80 Gy. For large fraction sizes (>=2.5 Gy), the incidence and severity of toxicity is unpredictable. For single fraction radiosurgery, a clear correlation has been demonstrated between the target size and the risk of adverse events. Substantial variation among different centers' reported outcomes have prevented us from making toxicity-risk predictions. Cognitive dysfunction in children is largely seen for whole brain doses of >=18 Gy. No substantial evidence has shown that RT induces irreversible cognitive decline in adults within 4 years of RT.

Lawrence, Yaacov Richard, E-mail: richard.lawrence@jefferson.ed [Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (United States); Li, X. Allen [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); El Naqa, Issam [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States); Hahn, Carol A. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Marks, Lawrence B. [Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC (United States); Merchant, Thomas E. [Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN (United States); Dicker, Adam P. [Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (United States)

2010-03-01T23:59:59.000Z

187

NUVABAT: Northeastern University Virtual Ankle and Balance Trainer Ye Ding1, Mark Sivak1  

E-Print Network (OSTI)

NUVABAT: Northeastern University Virtual Ankle and Balance Trainer Ye Ding1, Mark Sivak1 , Brian-373-5274. ABSTRACT The ability to control the ankle muscles and produce adequate range ofmotion in the ankle joints, such as stroke or traumatic brain injury, frequently lose gait and balance function due in part to loss of ankle

Mavroidis, Constantinos

188

Shock Waves (2012) 22:403415 DOI 10.1007/s00193-012-0399-2  

E-Print Network (OSTI)

wave profiles in simulated air blasts: experiment and computational modeling N. Chandra · S. Ganpule-Verlag 2012 Abstract Shock tubes have been extensively used in the study of blast traumatic brain injury dueShock Waves (2012) 22:403­415 DOI 10.1007/s00193-012-0399-2 ORIGINAL ARTICLE Evolution of blast

Farritor, Shane

189

Continuum modeling of a neuronal cell under blast loading Antoine Jrusalem a,  

E-Print Network (OSTI)

2012 Keywords: Continuum model Neuron Blast Cell damage Traumatic brain injury a b s t r a cContinuum modeling of a neuronal cell under blast loading Antoine JĂ©rusalem a, , Ming Dao b by proposing a continuum model of a neuronal cell submitted to blast loading. In this approach, the cytoplasm

Suresh, Subra

190

LIGHTWEIGHT Trauma MechanlC$  

E-Print Network (OSTI)

and human models to see how they reacted during the blast And students analyze video of the test, taken and Afghanistan returned with traumatic brain injuries, many of which were the result of improvised explosive Chandra's lab at the Univer sity of Nebraska simulate actual blasts with a piston driven by compressed

Farritor, Shane

191

Molecular-level computational investigation of shock-wave mitigation capability of polyurea  

E-Print Network (OSTI)

.g., those generated as a result of blast-wave impact). By analyzing molecular- level interactions-level material models). Extension of these relations into the ``weak-shock'' regime of interest from the traumatic brain injury prevention point of view is also discussed. Introduction Within this study, advanced

Grujicic, Mica

192

Faculty and Resident Scholarship 2013-2014 Name of Resident Presentation Name  

E-Print Network (OSTI)

Academy of Physical Medicine and Rehabilitation Annual Assembly and Technical Exhibition in National in National Harbor, Maryland on October 3-6, 2013 Dapul, Geraldine, Adam Pourcho, Parmod Mukhi. "Atypical Questionnaire [VHS-Q], in Traumatic Brain Injury Patients: A Prospective Study Accepted by Institutional Review

Finley Jr., Russell L.

193

Biotic injuries on conifer seedlings planted in forest understory environments  

Science Journals Connector (OSTI)

We investigated how partial overstory retention, understory vegetationmanagement, and protective Vexar® tubing affected the frequency andseverityof biotic injuries in a two-storied stand underplanted with western...

Thomas J. Brandeis; Michael Newton; Elizabeth C. Cole

2002-07-01T23:59:59.000Z

194

Injuries Due to Firearms in Three Cities  

Science Journals Connector (OSTI)

...its size. Galveston, an island city on the coast of Texas, has a population that is approximately 48 percent non-Hispanic white, 29 percent black, 21 percent Hispanic, and 2 percent Asian. In 1990, 24 percent of Galveston's citizens lived below the federal poverty line. In 1993, Galveston's rate of homicide... Injuries due to firearms are a major health problem in the United States.1–4 Although several studies have documented the impact of firearm-related deaths,5–15 little is known about the epidemiologic characteristics of nonfatal gunshot wounds.16–18 ...

Kellermann A.L.; Rivara F.P.; Lee R.K.

1996-11-07T23:59:59.000Z

195

THERMOACOUSTIC TOMOGRAPHY ARISING IN BRAIN IMAGING ...  

E-Print Network (OSTI)

In that case, the brain is represented by some domain. ?0 ? ?. Let ?1 be another domain representing the brain and the skull, so that ?0 ? ?1 ? ?, and N?1 n ?0 is ...

2011-02-21T23:59:59.000Z

196

Scientists examine proton radiography of brain mockup  

NLE Websites -- All DOE Office Websites (Extended Search)

Proton Radiography Of Brain Mockup Scientists examine proton radiography of brain mockup The use of such a high-energy proton beam is ideal for imaging small tumors within patients...

197

6.20 Mapping Human Brain Function  

NLE Websites -- All DOE Office Websites (Extended Search)

0 612011 6.20 Mapping Human Brain Function Many mysteries of the human brain have been unraveled by positron emission tomography (PET), an imaging tool used worldwide to diagnose...

198

Mind, Brain and Education as a Framework for Curricular Reform /  

E-Print Network (OSTI)

Eds. ). (2008). The educated brain. Cambridge: CambridgeM. M. & Gentile, D. A. (2011). Brains on video games. NatureA first course in mind, brain, and education. Mind, Brain, &

Larrison, Abigail L.

2013-01-01T23:59:59.000Z

199

Decision-support for the management of traumatically injured limb A project funded by under EPSRC's KTA Scheme ImpactQM, Sept 2010-Aug 2012  

E-Print Network (OSTI)

of limb injuries due to the nature of contemporary blast munitions, plus paradoxical improvements where the injury pattern falls to one extreme (mild limb injury, no case for amputation) or the other (severe injury, no choice BUT amputation). However, in other situations, the injured limb falls

Roelleke, Thomas

200

Brains and the city: big-brained passerine birds succeed in urban environments  

Science Journals Connector (OSTI)

...research-article Evolutionary biology 1001 60 70 14 Brains and the city: big-brained passerine...intuitive yet untested hypothesis that relative brain size is a key factor predisposing animals...data support findings linking relative brain size with the ability to persist in novel...

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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201

Brain-shift aware risk map for Deep Brain Stimulation Planning  

E-Print Network (OSTI)

Brain-shift aware risk map for Deep Brain Stimulation Planning Bilger Alexandre 1 , Essert Caroline / Université de Strasbourg, FRANCE Abstract. In Deep Brain Stimulation surgery, the eciency of the pro- cedure of the placement is dicult due to brain shifts occurring during and after the procedure. We propose an approach

Boyer, Edmond

202

Brain imaging methods used in experimental brain research such as Positron Emission Tomography (PET) and Functional  

E-Print Network (OSTI)

ABSTRACT Brain imaging methods used in experimental brain research such as Positron Emission of methods create statistical parametric maps (SPMs) of the brain on a voxel- basis. In our approach, they are best understood in the context of the underly- ing 3-D brain anatomy. However, despite the power

Mueller, Klaus

203

Neural Plasticity in Human Brain Connectivity: The Effects of Long Term Deep Brain Stimulation of the  

E-Print Network (OSTI)

Neural Plasticity in Human Brain Connectivity: The Effects of Long Term Deep Brain Stimulation of Oxford, Oxford, United Kingdom, 3 Center of Brain and Cognition, Theoretical and Computational are now well established for deep brain stimulation, but little is known about the effects of long

Deco, Gustavo

204

Adaptive Brain-Computer Interface Passive brain-computer interfaces are designed to use  

E-Print Network (OSTI)

Adaptive Brain-Computer Interface Abstract Passive brain-computer interfaces are designed to use brain activity as an additional input, allowing the adaptation of the interface in real time according to the user's mental state. While most current brain computer interface research (BCI) is designed for direct

Boetticher, Gary D.

205

Playing with Your Brain: Brain-Computer Interfaces and Anton Nijholt  

E-Print Network (OSTI)

Playing with Your Brain: Brain-Computer Interfaces and Games Anton Nijholt University of Twente role of brain-computer interaction in computer games and entertainment computing. The assumption is that brain activity, whether it is consciously controlled and directed by the user or just recorded in order

Rajamani, Sriram K.

206

Using Brain Weight to Predict Gestation in Mammals Bivariate Fit of Gestation By Brain Weight  

E-Print Network (OSTI)

1 Using Brain Weight to Predict Gestation in Mammals Bivariate Fit of Gestation By Brain Weight 0 100 200 300 400 500 Gestation 0 500 1000 1500 BrainWgt Linear Fit (All 50 mammals) Predicted Gestation = 85.248543 + 0.299867 Brain Weight Summary of Fit RSquare 0.372483 RSquare Adj 0.35941 Root Mean

Carriquiry, Alicia

207

Resin Canals in the Canadian Spruce (Picca canadensis (Mill.) B.S.P.)-An Anatomical Study, Especially in Relation to Traumatic Effects and Their Bearing on Phylogeny  

Science Journals Connector (OSTI)

...Anatomical Study, Especially in Relation to Traumatic Effects and Their Bearing on Phylogeny Robert Boyd Thomson Harold Boyd Sifton The Royal Society is collaborating with JSTOR to digitize, preserve, and extend access to Philosophical Transactions of the...

1926-01-01T23:59:59.000Z

208

Scientists protest funding bonanza for brain campus  

Science Journals Connector (OSTI)

Scientists protest funding bonanza for brain campus 10.1126/science.346.6214...won global attention for experiments with brain-controlled prostheses—and for master...S. $100 million in the Campus of the Brain, the neuroscience research and education...

Emily Underwood

2014-12-05T23:59:59.000Z

209

Cognitive and Brain Health Beckman Institute  

E-Print Network (OSTI)

Cognitive and Brain Health Beckman Institute FOR ADVANCED SCIENCE AND TECHNOLOGY #12;T he factors involved in cognition and brain health are many. Beckman Institute researchers have demonstrated the links between cognitive and brain health and lifestyle choices such as exercise and social and intellectual

Illinois at Urbana-Champaign, University of

210

Understanding complexity in the human brain  

E-Print Network (OSTI)

Understanding complexity in the human brain Danielle S. Bassett1 and Michael S. Gazzaniga2 1 the ultimate aim of neuroscientific enquiry is to gain an understanding of the brain and how its work- ings of mind­brain mechanisms if the cumulative findings from these neu- roscientific studies are coupled

Gazzaniga, Michael

211

VOLUMETRIC HARMONIC BRAIN MAPPING Yalin Wang1  

E-Print Network (OSTI)

VOLUMETRIC HARMONIC BRAIN MAPPING Yalin Wang1 , Xianfeng Gu2 , Tony F. Chan1 , Paul M. Thompson3 and Brain Research Institute, UCLA School of Medicine 4 Department of Mathematics, Harvard University. In this paper, we apply these two techniques to brain mapping problem. We use a tetrahedral mesh to represent

212

PUZZLING SYMPTOMS: EATING DISORDERS AND THE BRAIN  

E-Print Network (OSTI)

PUZZLING SYMPTOMS: EATING DISORDERS AND THE BRAIN A FAMILY GUIDE TO THE NEUROBIOLOGY OF EATING TO DO WITH THE BRAIN? Although people with eating disorders struggle to eat normally, this is only now believe that part of the problem has to do with how our brains process information about

Squire, Larry R.

213

Brain Organization and Computation Andreas Schierwagen  

E-Print Network (OSTI)

Brain Organization and Computation Andreas Schierwagen Institute for Computer Science, Intelligent://www.informatik.uni-leipzig.de/~schierwa Abstract. Theories of how the brain computes can be differentiated in three general conceptions systems approach. The discussion of key features of brain organization (i.e. structure with function

Schierwagen, Andreas

214

Brain dynamics promotes function Carlos Lourenco  

E-Print Network (OSTI)

Brain dynamics promotes function Carlos Louren¸co 1 Faculty of Sciences of the University of Lisbon, 1049-001 Lisboa - Portugal Abstract. Dynamical structure in the brain promotes biological func- tion. Computational scientists have new opportunities to receive 'algorithmic' inspiration from brain processes

Lisboa, Universidade TĂ©cnica de

215

Bernard J. Baars How Brain Reveals Mind  

E-Print Network (OSTI)

Bernard J. Baars How Brain Reveals Mind Neural Studies Support the Fundamental Role of Conscious Experience Abstract: In the last decade, careful studies of the living brain have opened the way for human by seven cases: (1) the discovery of widespread brain activation during conscious perception; (2) high

Memphis, University of

216

1. Brain vs Computer Brian Whitworth  

E-Print Network (OSTI)

gates (McCulloch & Pitts, 1943) · The brain has input/output · 1012+ (thousand billion) neurons per head7/12/2011 1 1. Brain vs Computer © Brian Whitworth An Overview http://brianwhitworth.com 2 Aim Compare how computers process information vs how the brain process the senses? Define the main differences

Whitworth, Brian

217

Blast injuries to the lung: epidemiology and management  

Science Journals Connector (OSTI)

...Medicine, College of Medical and Dental Sciences, University of Birmingham...blast injuries|blast lung|radiology of blast lung injury|conventional...context, clinical symptoms and radiology. Symptoms may include respiratory...patients (67%) for whom role 3 radiology was available and given that...

2011-01-01T23:59:59.000Z

218

Type A Investigation of the Electrical Arc Injury at the Stanford...  

Office of Environmental Management (EM)

of the Electrical Arc Injury at the Stanford Linear Accelerator Complex on October 11, 2004 Type A Investigation of the Electrical Arc Injury at the Stanford Linear Accelerator...

219

E-Print Network 3.0 - acute hepatic injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: acute liver injury, inflammation, and fibrosis. During...

220

Illness and Injury Surveillance Program Guidelines  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DOE-STD-1190-2007 DOE-STD-1190-2007 DOE STANDARD ILLNESS AND INJURY SURVEILLANCE PROGRAM GUIDELINES U.S. Department of Energy AREA OCSH Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. NOT MEASUREMENT SENSITIVE DOE-STD-1190-2007 Available on the Department of Energy Technical Standards Program Web site at http://tis.eh.doe.gov/techstds/ DOE-STD-1190-2007 Foreword 1. Use of this standard is not mandatory. Users should review the document and determine if it meets their purpose. 2. Comments (recommendations, additions, and deletions) that may be of use in improving this document should be addressed to: U.S. Department of Energy, Office of Health, c/o Dr. Cliff

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Type B Accident Investigation Of The February 25, 2009 Injury...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

To A Passenger In An Electric Cart At The Waste Isolation Pilot Plant, Carlsbad, New Mexico Type B Accident Investigation Of The February 25, 2009 Injury To A Passenger In An...

222

Shoulder injury reduction with post-offer testing  

E-Print Network (OSTI)

Objective: This study is an interventional evaluation of a post-offer employment testing. The study is designed to determine if shoulder injury rates are lowered when employees are placed at jobs they demonstrate the ...

Harbina, Gary L.; Shenoy, Catherine; Garcia, Amy; Olson, John C.

2011-06-21T23:59:59.000Z

223

Brain Mapping Using Topology Graphs Obtained by Surface Segmentation  

E-Print Network (OSTI)

Brain Mapping Using Topology Graphs Obtained by Surface Segmentation Fabien Vivodtzev1 , Lars@ucdavis.edu Summary. Brain mapping is a technique used to alleviate the tedious and time- consuming process of annotating brains by mapping existing annotations from brain atlases to individual brains. We introduce

Linsen, Lars

224

Labeling the Brain Surface Using a Deformable Multiresolution Mesh  

E-Print Network (OSTI)

Labeling the Brain Surface Using a Deformable Multiresolution Mesh Sylvain Jaume1 , Beno^it Macq2 Abstract. We propose to match a labeled mesh onto the patient brain surface in a multiresolution way for labeling the patient brain. Labeling the patient brain surface provides a map of the brain folds where

Desbrun, Mathieu

225

Center for BrainHealtH Scientific exploration at  

E-Print Network (OSTI)

Center for BrainHealtH #12;#12;Scientific exploration at BrainHealth is leading edge, innovative and transformative. leading tHe way in tHiS century'S greateSt ScientiFic cauSe The Center for Brain significant cause of the century: To understand, protect and heal the brain. Scientific exploration at Brain

O'Toole, Alice J.

226

Stanching the Brain Drain: Merit Scholarships and Post-Baccalaureate  

E-Print Network (OSTI)

Stanching the Brain Drain: Merit Scholarships and Post-Baccalaureate Migration Patterns Donald E of Brain DrainThe Issue of Brain Drain OutOut--migration of educated youngmigration of educated young is brain drain an issue?Where is brain drain an issue? #12;© 2004, D.E. Heller & K.R. Rogers© 2004, D

Heller, Don

227

Life Satisfaction Over the First Five Years Following Burn Injury  

E-Print Network (OSTI)

.......................................................................... 88 1 CHAPTER I INTRODUCTION In the United States, approximately 500,000 individuals present annually for treatment of burns; about 40,000 of whom require hospitalization (Esselman, 2007). These individuals are typically men, ages 20... year after hospitalization is almost universally a time of high distress for individuals with burn injuries (Patterson & Ford, 2000). The psychological distress following burn injury is said to be the “most disabling of secondary complications...

Hoskins, Jessica Lynne

2012-10-19T23:59:59.000Z

228

Imaging - Clearer brain scans ... | ornl.gov  

NLE Websites -- All DOE Office Websites (Extended Search)

Imaging - Clearer brain scans ... A clever signal noise reduction strategy developed by a team that includes Oak Ridge National Laboratory's Ben Lawrie could dramatically improve...

229

"Artificial" brains, electrical grids, and disease modeling:...  

NLE Websites -- All DOE Office Websites (Extended Search)

Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for...

230

Focal Brain Lesions to Critical Locations Cause Widespread Disruption of the Modular Organization of the Brain  

E-Print Network (OSTI)

Focal Brain Lesions to Critical Locations Cause Widespread Disruption of the Modular Organization of the Brain Caterina Gratton*, Emi M. Nomura*, Fernando PĂ©rez, and Mark DEsposito Abstract Although it is generally assumed that brain damage pre- dominantly affects only the function of the damaged region, here we

231

Brain size of Homo floresiensis and its evolutionary implications  

Science Journals Connector (OSTI)

...research-article Research articles 1001 70 144 133 Brain size of Homo floresiensis and its evolutionary...challenge in our understanding of human brain evolution. Some researchers hypothesize dramatic dwarfing of relative brain size from Homo erectus presumably without...

2013-01-01T23:59:59.000Z

232

Brain organization and the origin of insects: an assessment  

Science Journals Connector (OSTI)

...review-article Review articles 1001 70 133 Brain organization and the origin of insects...some features of insect and crustacean brains that speak against an entomostracan origin...received opinion. Neural organization in brain centres, comprising olfactory pathways...

2009-01-01T23:59:59.000Z

233

Connectomics: comprehensive approaches for whole-brain mapping  

Science Journals Connector (OSTI)

......comprehensive approaches for whole-brain mapping Shinsuke Shibata 1 * Yuji Komaki...for Marmoset Neural Architecture, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako...connectomics analysis is to understand whole-brain neural connections. This is accomplished......

Shinsuke Shibata; Yuji Komaki; Fumiko Seki; Michiko O. Inouye; Toshihiro Nagai; Hideyuki Okano

2014-12-01T23:59:59.000Z

234

Abstract 991: Brain metastasis depends on tumor cell initiated coagulation  

Science Journals Connector (OSTI)

...5-9, 2014; San Diego, CA Abstract 991: Brain metastasis depends on tumor cell initiated coagulation...La Jolla, CA. Background: The incidence of brain metastasis exceeds that of primary brain tumors tenfold and is most frequently associated...

Laurie J. Gay; John Day; Sarah LeBoeuf; Melissa Ritland; Zaverio Ruggeri; Wolfram Ruf; Brunhilde H. Felding

2014-10-01T23:59:59.000Z

235

Abstract 4036: Drug repurposing to treat melanoma brain metastases  

Science Journals Connector (OSTI)

...4036: Drug repurposing to treat melanoma brain metastases Terje Sundstrom 1 Jobin K...of patients with metastatic melanoma, brain metastases remain an intractable problem...target single genes or pathways critical to brain metastasis formation. In this work we...

Terje Sundstrřm; Jobin K. Varughese; Francisco Azuaje; Kjell Petersen; Clifford G. Tepper; Elizabeth Ingham; Lisa Even; Sarah Tam; Kai Ove Skaftnesmo; Morten Lund-Johansen; Rolf Bjerkvig; Katherine W. Ferrara; Frits A. Thorsen

2014-10-01T23:59:59.000Z

236

On Reverse Engineering in the Cognitive and Brain Andreas Schierwagen  

E-Print Network (OSTI)

On Reverse Engineering in the Cognitive and Brain Sciences Andreas Schierwagen Institute #12;On Reverse Engineering in the Cognitive and Brain Sciences Andreas Schierwagen Institute research initiatives try to utilize the operational principles of organisms and brains to develop

Schierwagen, Andreas

237

May 14, 2014 - "Your Brain on Conflict" | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

May 14, 2014 - "Your Brain on Conflict" May 14, 2014 - "Your Brain on Conflict" May 14, 2014 - "Your Brain on Conflict" Speaker: Dr. Julie Sasscer-Burgos, Psy.D., Deputy Chief,...

238

Take a Closer Look at the Brain | GE Global Research  

NLE Websites -- All DOE Office Websites (Extended Search)

Take a Closer Look at the Brain Take a Closer Look at the Brain Worldwide, more than 450 million people are living with compromised brain health. GE Global Research scientists,...

239

Variability of perceptual multistability: from brain state to individual trait  

Science Journals Connector (OSTI)

...Variability of perceptual multistability: from brain state to individual trait Andreas Kleinschmidt...multistability to demonstrate that the brain constructively interprets sensory input...is related to the context of the current brain state into which the processing of external...

2012-01-01T23:59:59.000Z

240

A PROPOSITIONAL REPRESENTATION MODEL OF ANATOMICAL AND FUNCTIONAL BRAIN DATA  

E-Print Network (OSTI)

A PROPOSITIONAL REPRESENTATION MODEL OF ANATOMICAL AND FUNCTIONAL BRAIN DATA Pablo MATURANA as a methodological tool to examine brain network organization, topology and complex dynamics, as well brain data and neuropsychological assessments linked to the functions explored in these assessments

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Matching Wits with Melanoma Brain Metastases: From Biology to Therapeutics  

Science Journals Connector (OSTI)

...Translations Matching Wits with Melanoma Brain Metastases: From Biology to Therapeutics...Pittsburgh, Pennsylvania. Melanoma brain metastases (MBM) present a significant...extensive molecular profiling of melanoma brain metastases (MBM), including a set of...

Hussein Tawbi

2014-11-01T23:59:59.000Z

242

ay 1 Mysteries of Brain : Come and `learn about the brain'. Have you wondered, "What is our brain like?" "How do we sense things around us?" and "How do we react to our environment?"  

E-Print Network (OSTI)

of Brain : Come and `learn about the brain'. Have you wondered, "What is our brain like?" "How do we sense about `neuron' as a basic unit of the brain, structure of the brain, functions closely associated with brain lobes and hemispheres and understanding the nervous system Special Focus: Brain Hemispheres

Narayanan, H.

243

Brain---computer interfaces for space applications  

Science Journals Connector (OSTI)

Recent experiments have shown the possibility to use the brain electrical activity to directly control the movement of robots. Such a kind of brain---computer interface is a natural way to augment human capabilities by providing a new interaction link ... Keywords: Astronauts, BCI, Space operations

Cristina Negueruela; Michael Broschart; Carlo Menon; José R. Millán

2011-06-01T23:59:59.000Z

244

Abnormal Electrical Brain Responses to Pitch in  

E-Print Network (OSTI)

Abnormal Electrical Brain Responses to Pitch in Congenital Amusia Isabelle Peretz, PhD,1 Elvira- sults suggest that this disorder is critically dependent on fine-grained pitch discrimination. Here, we2-P3 response elicited by pitch changes. This abnormal brain response begins as early as 200

245

STOCHASTIC GENERATION OF BIOLOGICALLY ACCURATE BRAIN NETWORKS  

E-Print Network (OSTI)

STOCHASTIC GENERATION OF BIOLOGICALLY ACCURATE BRAIN NETWORKS A Thesis by ARAVIND ALURI Submitted OF BIOLOGICALLY ACCURATE BRAIN NETWORKS A Thesis by ARAVIND ALURI Submitted to the Office of Graduate Studies Head of Department, Valerie Taylor December 2005 Major Subject: Computer Science #12;iii ABSTRACT

246

From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood-brain barrier?  

E-Print Network (OSTI)

and function of the blood-brain barrier,” Neurobiology ofV. Zlokovic, “The blood-brain barrier in health and chroniccell biology of the blood- brain barrier,” Annual Review of

Liu, Linan; Eckert, Mark A; Riazifar, Hamidreza; Kang, Dong-Ku; Agalliu, Dritan; Zhao, Weian

2013-01-01T23:59:59.000Z

247

Bigger brains cycle faster before neurogenesis begins: a comparison of brain development between chickens and bobwhite quail  

Science Journals Connector (OSTI)

...Research articles 1001 58 133 70 Bigger brains cycle faster before neurogenesis begins: a comparison of brain development between chickens and bobwhite...Irvine, CA 92697, USA The chicken brain is more than twice as big as the bobwhite...

2010-01-01T23:59:59.000Z

248

Abstract 4241: Preclinical studies of brain/brain tumor disposition and antitumor efficacy of the aromatase inhibitor letrozole  

Science Journals Connector (OSTI)

...San Diego, CA Abstract 4241: Preclinical studies of brain/brain tumor disposition and antitumor efficacy of the aromatase...target for the treatment of CNS malignancies, as well as brain disposition and anti-tumor efficacy of letrozole, an...

Nimita Dave; Pankaj B. Desai; Gary A. Gudelsky; Kathleen LaSance; Lionel M.L. Chow; Xiaoyang Qi

2014-10-01T23:59:59.000Z

249

Study of freshly excised brain tissues using terahertz imaging  

Science Journals Connector (OSTI)

We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz...

Oh, Seung Jae; Kim, Sang-Hoon; Ji, Young Bin; Jeong, Kiyoung; Park, Yeonji; Yang, Jaemoon; Park, Dong Woo; Noh, Sam Kyu; Kang, Seok-Gu; Huh, Yong-Min; Son, Joo-Hiuk; Suh, Jin-Suck

2014-01-01T23:59:59.000Z

250

Characterization of the Mouse Brain Proteome Using Global Proteomic...  

NLE Websites -- All DOE Office Websites (Extended Search)

the Mouse Brain Proteome Using Global Proteomic Analysis Complemented with Cysteinyl-Peptide Enrichment. Characterization of the Mouse Brain Proteome Using Global Proteomic...

251

Brain teasers traveling exhibit opens at Los Alamos National...  

NLE Websites -- All DOE Office Websites (Extended Search)

Brain teasers exhibit opens at museum Brain Teasers traveling exhibit opens at Los Alamos National Laboratory's Bradbury Science Museum The interactive exhibit is a collection of...

252

Seminar by Brain Laird (Friday, October 24) | The Ames Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Seminar by Brain Laird (Friday, October 24) Brain Laird, University of Kansas Department of Chemistry Chair, and Professor, will present "Premelting and Prefreezing at the...

253

Mapping protein abundance patterns in the brain using voxelation...  

NLE Websites -- All DOE Office Websites (Extended Search)

protein abundance patterns in the brain using voxelation combined with liquid chromatography and mass spectrometry. Mapping protein abundance patterns in the brain using voxelation...

254

Brain insulin lowers circulating BCAA levels by inducing hepatic...  

NLE Websites -- All DOE Office Websites (Extended Search)

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. Abstract:...

255

Sandia National Laboratories: The Brain: Key To a Better Computer  

NLE Websites -- All DOE Office Websites (Extended Search)

ClimateECResearch & CapabilitiesCapabilitiesThe Brain: Key To a Better Computer The Brain: Key To a Better Computer Sandian Selected for Outstanding Young Engineer Award Sandia...

256

Understanding Alterations in Brain Connectivity in Attention-Deficit/Hyperactivity Disorder Using  

E-Print Network (OSTI)

COMMENTARY Understanding Alterations in Brain Connectivity in Attention of neural systems and brain connections is an important new area of research to understand both normal brain connectivity and alterations in brain connectivity in neuropsychiatric disorders. The study of brain

257

Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury  

Science Journals Connector (OSTI)

Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study ... liver injury is amplified by bi...

Annayya R. Aroor; Ricardo J. Restrepo; Kusum K. Kharbanda…

2014-09-01T23:59:59.000Z

258

Moderators of the Safety Climate-Injury Relationship: A Meta-Analytic Examination  

E-Print Network (OSTI)

recommendations are proposed for future research of the safety climate-injury relationship including prospective longitudinal study designs with data collected and analyzed at the group-level of analysis and injuries operationalized at a greater level of severity....

Beus, Jeremy M.

2010-07-14T23:59:59.000Z

259

E-Print Network 3.0 - acute myocardial injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

1 High-Resolution Imaging with 99mTc-Glucarate for Assessing Myocardial Injury in Rat Heart Summary: High-Resolution Imaging with 99mTc-Glucarate for Assessing Myocardial Injury...

260

Understanding human-space suit interaction to prevent injury during extravehicular activity  

E-Print Network (OSTI)

Extravehicular Activity (EVA) is a critical component of human spaceflight. Working in gas-pressurized space suits, however, causes fatigue, unnecessary energy expenditure, and injury. The problem of injury is particularly ...

Anderson, Allison P. (Allison Paige)

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Effects of Surgical Repair or Reconstruction on Radiocarpal Mechanics from Wrists with Scapholunate Ligament Injury  

E-Print Network (OSTI)

Osteoarthritis as a result of injury/trauma is a significant problem, and there is still a need to develop tools for evaluating joint injuries and the effectiveness of surgical treatments. For the wrist in particular, ...

Johnson, Joshua

2013-05-31T23:59:59.000Z

262

Probing scale interaction in brain dynamics through synchronization  

Science Journals Connector (OSTI)

...Theme Issue Complex network theory and the brain compiled and edited by David Papo, Javier...Bullmore Probing scale interaction in brain dynamics through synchronization Alessandro...Theme Issue Complex network theory and the brain . The mammalian brain operates in multiple...

2014-01-01T23:59:59.000Z

263

Brain-Penetrant LSD1 Inhibitors Can Block Memory Consolidation  

Science Journals Connector (OSTI)

Brain-Penetrant LSD1 Inhibitors Can Block Memory Consolidation ... Modulation of histone modifications in the brain may represent a new mechanism for brain disorder therapy. ... The two most potent and selective inhibitors were used to demonstrate brain penetration when administered systemically to rodents. ...

Ramesh Neelamegam; Emily L. Ricq; Melissa Malvaez; Debasis Patnaik; Stephanie Norton; Stephen M. Carlin; Ian T. Hill; Marcelo A. Wood; Stephen J. Haggarty; Jacob M. Hooker

2011-11-18T23:59:59.000Z

264

Modelling of Brain Consciousness based on Collaborative Adaptive Filters  

E-Print Network (OSTI)

Modelling of Brain Consciousness based on Collaborative Adaptive Filters Ling Lia, , Yili Xiaa of Technology, Japan c Laboratory for Advanced Brain Signal Processing, RIKEN Brain Science Institute, Saitama method for the discrimination between discrete states of brain con- sciousness is proposed, achieved

Kent, University of

265

Brain donation is one of the most important contributions to  

E-Print Network (OSTI)

01-19-09 Brain donation is one of the most important contributions to research. Brain donations 200 brain tissue samples to researchers. Some of the major findings that came about through utilization of this precious gift include: In 2006, Todd Preuss and his team showed that certain brain

Contractor, Anis

266

Random Forest Classification for Training a Brain Computer Interface (BCI)  

E-Print Network (OSTI)

Random Forest Classification for Training a Brain Computer Interface (BCI) Abstract1 Brain brain activity. Most3 existing BCIs detect specific mental activity in a so-called synchronous4 paradigm extraction7 followed by a classification scheme to detect intentions from the brain8 signal. In this paper

de Freitas, Nando

267

Early developmental patterning sets the stage for brain evolution  

E-Print Network (OSTI)

Early developmental patterning sets the stage for brain evolution Hans A. Hofmann1 Section of Texas, Austin, TX 78712 T he evolution of brain structure and function has long fascinated biologists of the brain--or brain region--and body size across a wide range of vertebrates (1). Besides random drift, two

Hofmann, Hans A.

268

Neuronal computing or computational neuroscience: brains vs. computers  

E-Print Network (OSTI)

Neuronal computing or computational neuroscience: brains vs. computers Leslie S. Smith, Department it matters · Brains and computers: ­ Historical analogies ­ Levels in computers and brains · Mixing levels brains for robot rats! · (Chant of the Neuromorphic Engineers, Telluride, c 1998). · Hardware oriented

Smith, Leslie S.

269

The Noisy Brain: Stochastic Dynamics as a Principle of  

E-Print Network (OSTI)

The Noisy Brain: Stochastic Dynamics as a Principle of Brain Function Edmund T. Rolls Oxford Centre random spiking times of individual neurons produce a source of noise in the brain. The aim of this book is to consider the effects of this and other noise on brain pro- cessing. We show that in cortical networks

Rolls, Edmund T.

270

The brain: What is critical about it? Dante R. Chialvo  

E-Print Network (OSTI)

The brain: What is critical about it? Dante R. Chialvo , Pablo Balenzuela and Daniel Fraiman the recent proposal that the most fascinating brain properties are related to the fact that it always stays results, as well as further implications of this view of the functioning brain. Keywords: Brain, critical

Chialvo, Dante R.

271

Introduction Welcome. Brain Basics provides information on how the  

E-Print Network (OSTI)

1 Introduction Welcome. Brain Basics provides information on how the brain works, how mental illnesses are disorders of the brain, and ongoing research that helps us better understand and treat be moderate, or serious and cause severe disability. Through research, we know that mental disorders are brain

Bandettini, Peter A.

272

An MRI Segmentation Framework for Brains with Anatomical Marcelinus Prastawa  

E-Print Network (OSTI)

An MRI Segmentation Framework for Brains with Anatomical Deviations Marcelinus Prastawa;ABSTRACT MARCELINUS PRASTAWA: An MRI Segmentation Framework for Brains with Anatomical Deviations (Under the direction of Guido Gerig, Ph.D.) The segmentation of brain Magnetic Resonance (MR) images, where the brain

Whitton, Mary C.

273

Norme Attuative della Cognitive and Brain Sciences Doctoral School  

E-Print Network (OSTI)

1 Norme Attuative della Cognitive and Brain Sciences Doctoral School Executive Regulations of the Cognitive and Brain Sciences Doctoral School Norme Attuative della Scuola di Dottorato in Cognitive and Brain Sciences Executive Regulations of the Cognitive and Brain Sciences Doctoral School Approvate nella

274

Doppler Ultrasound Driven Biomechanical Model of the Brain for  

E-Print Network (OSTI)

Doppler Ultrasound Driven Biomechanical Model of the Brain for Intraoperative Brain of the target is essential to reduce mor- bidity during brain tumor removal interventions. Yet, image-guided neu- rosurgery faces an important issue for large skull openings where brain soft-tissues can exhibit large

Paris-Sud XI, Université de

275

Auditory Brain Stem Response to Complex Sounds: Erika Skoe1  

E-Print Network (OSTI)

& Williston 1971; Moushegian et al. 1973), auditory brain stem responses (ABRs) can be measured using scalp

276

MAPPING THE ANKLE JOINTS PASSIVE MOTION AND MEASURING THE EFFECT OF INJURY ON LIGAMENT CONSTRAINT AT THE ANKLE JOINT.  

E-Print Network (OSTI)

??Lateral ankle sprain is one of the most common sports injuries, and having a better understanding of how ligament constraint changes after injury can assist… (more)

West III, James E.

2011-01-01T23:59:59.000Z

277

More Clues About Obesity From Brain Imaging  

NLE Websites -- All DOE Office Websites (Extended Search)

June 20, 2002 June 20, 2002 Electronic newsroom 02-51 More Clues About Obesity Revealed by Brain-Imaging Study UPTON, NY — The idea that obese people eat too much because they find food more palatable than lean people do has gained support from a new brain-imaging study at the U.S. Department of Energy’s Brookhaven National Laboratory. The study reveals that the parts of the brain responsible for sensation in the mouth, lips, and tongue are more active in obese people than in normal-weight control subjects. “This enhanced activity in brain regions involved with sensory processing of food could make obese people more sensitive to the rewarding properties of food, and could be one of the reasons they overeat,” said Brookhaven physician Gene-Jack Wang, lead author of the study.

278

Visualizing Brain Metals in Health and Disease  

NLE Websites -- All DOE Office Websites (Extended Search)

Visualizing Brain Metals in Health and Visualizing Brain Metals in Health and Disease figure 1 Fig. 1. Rapid-scanning x-ray fluorescence mapping ex perimental setup. Synchrotron x-rays at 11 keV passed through a 50 µm aperture (Ap). The beam intensity was monitored with a N2-filled ion chamber (I0). The brain slice was mounted vertically on a motorized stage (St) at 45° to the incident x-ray beam and raster scanned in the beam. A 13-element Ge detector (Ge) was positioned at a 90° angle to the beam. We all require iron, copper and zinc for normal brain function but metal metabolism becomes dysregulated in a variety of neurodegenerative diseases. Metals accumulate in Alzheimer's dementia and Parkinson's disease and are deficient in Menkes disease. Whether excess metals appear as a cause or a

279

NATIONAL BRAIN RESEARCH CENTRE ANNUAL REPORT  

E-Print Network (OSTI)

, assimilate, publish and disseminate data and information on aspects relevant to neuroscience in the field of brain and neurosciences research. · To establish one or more satellite centers to serve

Dhingra, Narender K.

280

ANNUAL REPORT National Brain Research Centre  

E-Print Network (OSTI)

. To collect, assimilate, publish and disseminate data and information on aspects relevant to neuroscience working in the field of brain and neurosciences research. To establish one or more satellite centres

Dhingra, Narender K.

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

COLLOQUIUM: Your Restless Brain: Changing Continually Throughout...  

NLE Websites -- All DOE Office Websites (Extended Search)

Archive Events April 2, 2014, 4:00pm to 5:30pm MBG Auditorium COLLOQUIUM: Your Restless Brain: Changing Continually Throughout the Day and Night Professor Barry Jacobs Princeton...

282

Applications How to build a brain  

E-Print Network (OSTI)

Applications How to build a brain Chris & Terry Centre for Theoretical Neuroscience University y z A B T #12;Learning results #12;Rule (R) (Language Areas) Context (VMPFC) Right Inferior Frontal

Anderson, Charles H.

283

Stochastic generation of biologically accurate brain networks  

E-Print Network (OSTI)

Gen . . . . . . . . . . . . . . . . . . . 31 2. Synapses in NeuroConstruct . . . . . . . . . . . . . . 32 D. Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 V LATTICE/GROUP : : : : : : : : : : : : : : : : : : : : : : : : : 35 A. Introduction... . . . . . . . . . . . . . . . . . . . . . . . . . . 35 B. Background . . . . . . . . . . . . . . . . . . . . . . . . . . 35 1. Lattice geometry . . . . . . . . . . . . . . . . . . . . . 35 2. Examples of lattice geometry . . . . . . . . . . . . . . 35 C. Lattice structures in the brain...

Aluri, Aravind

2006-04-12T23:59:59.000Z

284

User adaptation to injury protection systems: its effect on fatalities, and possible causes  

E-Print Network (OSTI)

and Morgan, D . (1987). Motorcycle and bicycle protectivepreventing injury i n motorcycle riders. Cochrane Databaseimpact improvements and motorcycle helmets Perceptibility

Grembek, Offer

2010-01-01T23:59:59.000Z

285

User adaptation to injury protection systems: its effect on fatalities, and possible causes  

E-Print Network (OSTI)

impact improvements and motorcycle helmets . . . . . . . . .and Morgan, D. (1987). Motorcycle and bicycle protectivepreventing injury in motorcycle riders. Cochrane Database of

Grembek, Offer

2010-01-01T23:59:59.000Z

286

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor  

E-Print Network (OSTI)

Z, Plotkine M, Szabo C, Marchand-Verrecchia C: BeneficialM, Gillet B, Meric P, Marchand-Leroux C: Effect of acute

2012-01-01T23:59:59.000Z

287

e-Infrastructures Fostering Multi-Centre Collaborative Research into the Intensive Care Management of Patients with Brain Injury  

E-Print Network (OSTI)

Sinnott,R.O. Piper,I. Handbook of Research on Computational Grid Technologies for Life Sciences, Biomedicine and Healthcare, IGI Press, November 2008

Sinnott, R.O.

288

Aging and functional brain networks  

SciTech Connect

Aging is associated with changes in human brain anatomy and function and cognitive decline. Recent studies suggest the aging decline of major functional connectivity hubs in the 'default-mode' network (DMN). Aging effects on other networks, however, are largely unknown. We hypothesized that aging would be associated with a decline of short- and long-range functional connectivity density (FCD) hubs in the DMN. To test this hypothesis, we evaluated resting-state data sets corresponding to 913 healthy subjects from a public magnetic resonance imaging database using functional connectivity density mapping (FCDM), a voxelwise and data-driven approach, together with parallel computing. Aging was associated with pronounced long-range FCD decreases in DMN and dorsal attention network (DAN) and with increases in somatosensory and subcortical networks. Aging effects in these networks were stronger for long-range than for short-range FCD and were also detected at the level of the main functional hubs. Females had higher short- and long-range FCD in DMN and lower FCD in the somatosensory network than males, but the gender by age interaction effects were not significant for any of the networks or hubs. These findings suggest that long-range connections may be more vulnerable to aging effects than short-range connections and that, in addition to the DMN, the DAN is also sensitive to aging effects, which could underlie the deterioration of attention processes that occurs with aging.

Tomasi D.; Tomasi, D.; Volkow, N.D.

2011-07-11T23:59:59.000Z

289

Abstract -Other researchers have proposed that the brain parenchymal fraction (or brain atrophy) may be a good surrogate  

E-Print Network (OSTI)

Abstract - Other researchers have proposed that the brain parenchymal fraction (or brain atrophy. This paper considers various factors influencing the measure of the brain parenchymal fraction obtained from head MRI scans. An automatic segmentation method for the brain and for the cerebral spinal fluid

Orchard, Jeffery J.

290

Plasticity of the human brain " We never use the same brain twice" Arno Villringer and Burkhard Pleger  

E-Print Network (OSTI)

Plasticity of the human brain " We never use the same brain twice" Arno Villringer and Burkhard Pleger Max Planck Institute for Human Brain and Cognitive Sciences, Leipzig Summary With the advent of noninvasive neuroimaging the human brain has become accessible for invivo

291

Brain Cluster Leiden -InventoryBrain Cluster Leiden -Inventory Inventory of organizations working inInventory of organizations working in  

E-Print Network (OSTI)

Brain Cluster Leiden - InventoryBrain Cluster Leiden - Inventory Inventory of organizations working brain Annelieke Hoenderkamp Leiden Bio Science Park foundation in assignment of Municipality of Leiden November 2011 #12;IntroductionIntroduction · The brain is the most complex organ in the human body. Its

Galis, Frietson

292

Abstract--Recent brain imaging studies on primates revealed that a network of brain areas is activated both during  

E-Print Network (OSTI)

9 Abstract-- Recent brain imaging studies on primates revealed that a network of brain areas and constitutes an efficient behavior of mammals. Recent brain imaging studies investigate where and how observed to this direction [23]. Additional studies [10],[16] indicate the existence of a much wider network of brain areas

Trahanias, Panos

293

Near to the Brain: Functional Near-Infrared Spectroscopy as a Lightweight Brain Imaging Technique for Visualization  

E-Print Network (OSTI)

Near to the Brain: Functional Near-Infrared Spectroscopy as a Lightweight Brain Imaging Technique the use of cumbersome or expensive brain imaging equipment. In recent years, functional near-infrared near-infrared spectroscopy (fNIRS) is an emerging technology for brain imaging being developed

Tomkins, Andrew

294

"Improving the quality of life through the mitigation and prevention of injury  

E-Print Network (OSTI)

of pedestrian accidents using Madymo models and Optimization Techniques. Crash Investigations The Crash Injury trauma to ballistics and blast. Our unique skills allow us to examine and prevent injuries from"Improving the quality of life through the mitigation and prevention of injury made possible

Acton, Scott

295

REGULAR ARTICLE European corn borer injury effects on lignin, carbon  

E-Print Network (OSTI)

REGULAR ARTICLE European corn borer injury effects on lignin, carbon and nitrogen in corn tissues herbivores often stimulate lignin deposition in injured plant tissue, but it is not known whether corn (Zea (Bacillus thuringiensis) genetic modifica- tion is also reported to affect lignin in corn. This study

Beaudoin, Georges

296

Statins Reduce Neurologic Injury in Asymptomatic Carotid Endarterectomy Patients  

E-Print Network (OSTI)

stenosis scheduled for elective CEA consented to participate in this observational study of perioperative neurologic injury. Results--Patients taking statins had a lower incidence of clinical stroke (0.0% vs. 3.1%, P=0.02) and cognitive dysfunction (11.0% vs. 20.2%, P=0.03). In a multivariate regression model

297

RESEARCH Open Access First evidence of subclinical renal tubular injury  

E-Print Network (OSTI)

RESEARCH Open Access First evidence of subclinical renal tubular injury during sickle-cell crisis classically involved in sickle-cell nephropathy include endothelial dysfunction and vascular occlusion during VOC. Background Sickle-cell nephropathy (SCN), a major mortality risk factor in sickle-cell

Paris-Sud XI, Université de

298

Risk factors for injury accidents among moped and motorcycle riders  

E-Print Network (OSTI)

Risk factors for injury accidents among moped and motorcycle riders Aurélie Moskal a , Jean on the vehicle. Moped and motorcycle riders are analyzed separately, adjusting for the main characteristics of the accident. Results: for both moped and motorcycle riders, being male, not wearing a helmet, exceeding

Paris-Sud XI, Université de

299

Center For Brain Science 7/6/10 Center for Brain Science Neuroimaging  

E-Print Network (OSTI)

Center For Brain Science 7/6/10 Center for Brain Science Neuroimaging MR Suite Rules and Procedures's compatibility with the magnetic field, Tammy Moran must be notified. DO NOT SCAN! · Have all participants change. They tend to land on the floor and find their way into the magnet room and into the magnet. · Check

Datta, Sandeep Robert

300

Center For Brain Science 3/5/12 Center for Brain Science Neuroimaging  

E-Print Network (OSTI)

Center For Brain Science 3/5/12 1 Center for Brain Science Neuroimaging Training Levels are as follows: Level 1: Observer - Anyone and everyone wishing to observe research around the MRI magnet must first watch the safety video. Once you have done this you are permitted to be in the magnetic

Datta, Sandeep Robert

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Center For Brain Science 11/27/12 Center for Brain Science Neuroimaging  

E-Print Network (OSTI)

Center For Brain Science 11/27/12 1 Center for Brain Science Neuroimaging Potential MRI Hazards provides an introduction to some of the safety concerns associated with MR research. Static Magnetic Field: Projectiles - The most immediate danger associated with a magnetic environment is the attraction between

Datta, Sandeep Robert

302

BRAIN, BEHAVIOUR AND NEUROIMAGING A seminar to create awareness about the mysteries of the brain  

E-Print Network (OSTI)

BRAIN, BEHAVIOUR AND NEUROIMAGING A seminar to create awareness about the mysteries of the brain Srinivasan Professor & Head, Centre of Behavioural and Cognitive Sciences, University of Allahabad.D. Head of Department, Physiology, S.M.S. Medical College, Jaipur Psychology and Police investigations Mr

Narayanan, H.

303

E-Print Network 3.0 - automated brain labeling Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

brain labeling Search Powered by Explorit Topic List Advanced Search Sample search results for: automated brain labeling Page: << < 1 2 3 4 5 > >> 1 Labeling the Brain Surface...

304

Helmets Designed by Supercomputers Help Warfighters at Home | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Helmets Designed by Supercomputers Help Warfighters at Home Helmets Designed by Supercomputers Help Warfighters at Home Helmets Designed by Supercomputers Help Warfighters at Home December 26, 2012 - 1:40pm Addthis Paul Taylor, right, and John Ludwigsen, center, both researchers with Sandia’s Terminal Ballistics Technology Department, and Corey Ford, a neurologist at the University of New Mexico's Health Sciences Center, discuss their research on traumatic brain injuries. | Photo by Randy Montoya Paul Taylor, right, and John Ludwigsen, center, both researchers with Sandia's Terminal Ballistics Technology Department, and Corey Ford, a neurologist at the University of New Mexico's Health Sciences Center, discuss their research on traumatic brain injuries. | Photo by Randy Montoya Michael Hess Michael Hess Former Digital Communications Specialist, Office of Public Affairs

305

Scientists examine proton radiography of brain mockup  

NLE Websites -- All DOE Office Websites (Extended Search)

Proton Radiography Of Brain Mockup Proton Radiography Of Brain Mockup Scientists examine proton radiography of brain mockup The use of such a high-energy proton beam is ideal for imaging small tumors within patients for targeted proton therapy. March 25, 2013 Proton radiograph of a high-fidelity mockup of a human head Proton radiograph of a high-fidelity mockup of a human head. Proton radiography, which was invented at Los Alamos, employs a high-energy proton beam to image the properties and behavior of materials. Los Alamos researchers and German collaborators have investigated the application of giga-electron volt (GeV, or billion electron volts) energy proton beams for medical imaging in combination with proton radiation treatment for cancer. The use of such a high-energy proton beam is ideal

306

Scientists examine proton radiography of brain mockup  

NLE Websites -- All DOE Office Websites (Extended Search)

Proton Radiography Of Brain Mockup Proton Radiography Of Brain Mockup Scientists examine proton radiography of brain mockup The use of such a high-energy proton beam is ideal for imaging small tumors within patients for targeted proton therapy. March 25, 2013 Proton radiograph of a high-fidelity mockup of a human head Proton radiograph of a high-fidelity mockup of a human head. Proton radiography, which was invented at Los Alamos, employs a high-energy proton beam to image the properties and behavior of materials. Los Alamos researchers and German collaborators have investigated the application of giga-electron volt (GeV, or billion electron volts) energy proton beams for medical imaging in combination with proton radiation treatment for cancer. The use of such a high-energy proton beam is ideal

307

An Examination of Music Therapy with Adolescent Populations  

E-Print Network (OSTI)

who shared their knowledge and supported me throughout my studies. Special thanks to Dr. Colwell who patiently worked with me on this thesis and worked hard to help me finish it up this semester. Thank you to my Mom, Dad, and sister for all..., and traumatic brain injury. Juvenile delinquents, pregnant teens, abused adolescents and grieving adolescents have also received music therapy services. See Appendix A for article citations. This same review of music therapy journal articles revealed...

Seagren, Stephanie

2009-05-01T23:59:59.000Z

308

Role of P-Glycoprotein on the Brain Penetration and Brain Pharmacodynamic Activity of the MEK Inhibitor Cobimetinib  

Science Journals Connector (OSTI)

Role of P-Glycoprotein on the Brain Penetration and Brain Pharmacodynamic Activity of the MEK Inhibitor Cobimetinib ... Summary of mean ± SD unbound brain, plasma, and CSF concentrations (5 mg/kg PO); pharmacokinetic profile of cobimetinib observed in mice after administration of cobimetinib; effect of oral co-administration of cobimetinib (10 mg/kg) and vemurafenib (50 mg/kg) on cobimetinib brain penetration in mice; vemurafenib brain penetration in mice; and representative MALDI signal intensity and cresyl violet stained brains observed in animals (at 1 h). ...

Edna F. Choo; Justin Ly; Jocelyn Chan; Sheerin K. Shahidi-Latham; Kirsten Messick; Emile Plise; Cristine M. Quiason; Lulu Yang

2014-09-22T23:59:59.000Z

309

Deep-Brain Stimulation for Parkinson's Disease  

Science Journals Connector (OSTI)

...are related to electrical stimulation and may be addressed by adjustment of device programming or discontinuation of therapy. Neurologic side effects of deep-brain stimulation include cognitive impairment, memory deficits, difficulties with speech, disequilibrium, dysphagia, and motor and sensory disturbances... A 72-year-old man with Parkinson's disease is referred for consideration of deep-brain stimulation, which involves the implantation of electrodes in one of the nuclei of the basal ganglia and can result in significant improvement in some symptoms of Parkinson's disease.

Okun M.S.

2012-10-18T23:59:59.000Z

310

Classification of whole brain fMRI activation patterns  

E-Print Network (OSTI)

Functional magnetic resonance imaging (fMRI) is an imaging technology which is primarily used to perform brain activation studies by measuring neural activity in the brain. It is an interesting question whether patterns ...

Balc?, Serdar Kemal

2008-01-01T23:59:59.000Z

311

Compartmentalization and axon guidance in the Drosophila brain  

E-Print Network (OSTI)

The Drosophila brain is composed of many morphologically and functionally distinct processing centers and brain morphogenesis depends on the creation and maintenance of distinct boundaries between adjacent regions to prevent ...

Tayler, Timothy D., 1972-

2005-01-01T23:59:59.000Z

312

The Ballistic Pressure Wave Theory of Handgun Bullet Incapacitation  

E-Print Network (OSTI)

This paper presents a summary of seven distinct chains of evidence, which, taken together, provide compelling support for the theory that a ballistic pressure wave radiating outward from the penetrating projectile can contribute to wounding and incapacitating effects of handgun bullets. These chains of evidence include the fluid percussion model of traumatic brain injury, observations of remote ballistic pressure wave injury in animal models, observations of rapid incapacitation highly correlated with pressure magnitude in animal models, epidemiological data from human shootings showing that the probability of incapacitation increases with peak pressure magnitude, case studies in humans showing remote pressure wave damage in the brain and spinal cord, and observations of blast waves causing remote brain injury.

Courtney, Michael

2008-01-01T23:59:59.000Z

313

Human embryonic stem cells for brain repair?  

Science Journals Connector (OSTI)

...repair compiled by Siddharthan Chandran, Maeve Caldwell and Nick Allen Human embryonic stem cells for brain repair? Su-Chun...stromal cell co-culture system. This type of technique has merits in its simplicity and the differentiated progenies appear to...

2008-01-01T23:59:59.000Z

314

NEW INSIGHTS INTO BRAIN SWELLING AFTER STROKE  

E-Print Network (OSTI)

NEW INSIGHTS INTO BRAIN SWELLING AFTER STROKE W Taylor Kimberly MD PhD 6 May 2013 #12;OBJECTIVES · Background: introduction to stroke · Mechanism: types of cerebral edema · Specific target: preclinical data-Pilot imaging and plasma biomarkers · Next steps: GAMES-RP #12;BACKGROUND · 800,000 strokes occur each year · 4

Sabatini, David M.

315

AGI and neuroscience: open sourcing the brain  

Science Journals Connector (OSTI)

Can research into artificial general intelligence actually benefit from neuroscience and vice-versa? Many AGI researchers are interested in the human mind. Within reasonable limits, we can posit that the human mind is a working general intelligence. ... Keywords: artificial intelligence, brain emulation, general intelligence, hidden functions, human enhancement, human mind, neuroscience, substrate-independent minds

Randal A. Koene

2011-08-01T23:59:59.000Z

316

Von Economo Neurons in the Elephant Brain  

E-Print Network (OSTI)

Von Economo Neurons in the Elephant Brain ATIYA Y. HAKEEM,1 * CHET C. SHERWOOD,2 CHRISTOPHER J elephants. The VENs in the elephant are primarily found in similar locations to those in the other species- nids, cetaceans, and elephants, and may reflect a specialization for the rapid transmission of crucial

Allman, John M.

317

BDP: BrainSuite Diffusion Pipeline  

E-Print Network (OSTI)

BDP: BrainSuite Diffusion Pipeline Chitresh Bhushan #12; Quantify microstructural tissue ROI Connectivity ROI Statistics MPRAGE Diffusion #12;Diffusion Pipeline Dicom to NIfTI Co ROIs Custom ROIs #12;Diffusion Pipeline Dicom to NIfTI Co-registration Diffusion Modeling Tractography

Leahy, Richard M.

318

The brain's connective core and its role in animal cognition  

Science Journals Connector (OSTI)

...Nicola S. Clayton and Alex Thornton The brain's connective core and its role in animal...paper addresses the question of how the brain of an animal achieves cognitive integration-that...possible for unanticipated coalitions of brain processes to form. This facilitates the...

2012-01-01T23:59:59.000Z

319

Brain development and predation: plastic responses depend on evolutionary history  

Science Journals Connector (OSTI)

...research-article Evolutionary biology 1001 70 60 Brain development and predation: plastic responses...PO Box 65, 00014, Finland Although the brain is known to be a very plastic organ, the...interactions like predation or competition on brain development have remained largely unexplored...

2012-01-01T23:59:59.000Z

320

Proteomic Study of Pilocytic Astrocytoma Pediatric Brain Tumor Intracystic Fluid  

Science Journals Connector (OSTI)

Proteomic Study of Pilocytic Astrocytoma Pediatric Brain Tumor Intracystic Fluid ... Liquid chromatography in coupling with high-resolution ESI-LTQ-Orbitrap mass spectrometry was applied for a proteomic study of pediatric pilocytic astrocytoma brain tumor intracystic fluid by an integrated top-down/bottom-up platform. ... proteomics; brain tumors; pylocitic astrocytoma; intracystic fluid; mass spectrometry ...

Ilaria Inserra; Federica Iavarone; Claudia Martelli; Luca D’Angelo; Daniela Delfino; Diana Valeria Rossetti; Gianpiero Tamburrini; Luca Massimi; Massimo Caldarelli; Concezio Di Rocco; Irene Messana; Massimo Castagnola; Claudia Desiderio

2014-09-25T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

STOCKER FLY BRAIN IMMUNOFLUORESCENCE PROTOCOL January 8, 2001  

E-Print Network (OSTI)

1 STOCKER FLY BRAIN IMMUNOFLUORESCENCE PROTOCOL January 8, 2001 Vosshall Lab 1. Anesthetize flies the brain, starting with the removal of the proboscis. Gently peel away the cuticle at the back of the fly the esophagus (hole in brain). Once all the cuticle has been removed, gently remove the fat body and trachea

322

Functional Geometry Alignment and Localization of Brain Areas  

E-Print Network (OSTI)

Functional Geometry Alignment and Localization of Brain Areas Georg Langs, Polina Golland Computer@bwh.harvard.edu, lrigolo@bwh.harvard.edu agolby@bwh.harvard.edu Abstract Matching functional brain regions across. It is particularly difficult, but highly relevant, for patients with pathologies such as brain tumors, which can

Golland, Polina

323

The Dynamics of Brain-Body-Environment Systems  

E-Print Network (OSTI)

The Dynamics of Brain-Body-Environment Systems in Behavior and Cognition An NSF IGERT Training Program Environment BodyAgent Agent Graduate Traineeships Available in Research Themes * Brain Dynamics the dynamical interaction of brains with bodies, agents with their environments, and agents with other agents

Menczer, Filippo

324

Brain donation is one of the most important contributions to  

E-Print Network (OSTI)

01-19-09 Brain donation is one of the most important contributions to research. As researchers work to better understand disorders that affect mental function with aging, brain donations are essential to their progress. By studying the anatomy, pathology, and chemistry of the brains of people with memory problems

Contractor, Anis

325

COMPARING THE EMOTIONAL BRAINS OF HUMANS AND OTHER ANIMALS  

E-Print Network (OSTI)

25 3 COMPARING THE EMOTIONAL BRAINS OF HUMANS AND OTHER ANIMALS Kent C. Berridge How is emotion embodied in the brain? That is the ques- tion posed by affective neuroscience (Cacioppo & Gardner, 1999 and emotion at both psychological and neurobiological levels. Evidence regarding the brain substrates

Berridge, Kent

326

A conserved pattern of brain scaling from sharks to primates  

E-Print Network (OSTI)

A conserved pattern of brain scaling from sharks to primates Kara E. Yopaka,b,1 , Thomas J. Lisneyc June 4, 2010 (received for review February 23, 2010) Several patterns of brain allometry previously. In each clade, the relative size of brain parts, with the notable exception of the olfactory bulbs

Finlay, Barbara L.

327

Automatic Segmentation of Neonatal Brain MRI Marcel Prastawa, 2  

E-Print Network (OSTI)

Automatic Segmentation of Neonatal Brain MRI 1 Marcel Prastawa, 2 John Gilmore, 3 Weili Lin, and 1 segmentation method for neonatal MRI. The analysis and study of neonatal brain MRI is of great interest due probabilistic brain atlas to select training samples and to be used as a spatial prior. The method first uses

Prastawa, Marcel

328

Brief Communications Why Sex Matters: Brain Size Independent Differences in  

E-Print Network (OSTI)

Brief Communications Why Sex Matters: Brain Size Independent Differences in Gray Matter, Germany The different brain anatomy of men and women is both a classic and continuing topic of major interest. Among the most replicated and robust sex differences are larger overall brain dimensions in men

Gaser, Christian

329

Intra-operative Registration for Deep Brain Stimulation Procedures  

E-Print Network (OSTI)

Intra-operative Registration for Deep Brain Stimulation Procedures based on a Full Physics Head�e Rennes I Abstract. Brain deformation is a factor of inaccuracy during stereo- tactic neurosurgeries to update the pre-operative planning based on a physical simulation of the brain shift. A minimization

Boyer, Edmond

330

Brains, maturation times, and parenting John Allman*, Andrea Hasenstaub  

E-Print Network (OSTI)

Commentary Brains, maturation times, and parenting John Allman*, Andrea Hasenstaub Division have favored the evolution of genes that retard brain senescence, specifically recently evolved, and the influence of this slow development on parental dependence and patterns of survival. Large brains are ex

Allman, John M.

331

New Approaches in Brain-Computer Music Interfacing  

E-Print Network (OSTI)

New Approaches in Brain-Computer Music Interfacing Mapping EEG for Real-Time Musical Control Eaton-going research into the creation of performance and compositional tools using a Brain- Computer Music Interface) for performance, and highlights the need for further practice-led research in this field. Keywords- brain, music

Miranda, Eduardo Reck

332

Construction of Anatomically Correct Models of Mouse Brain Networks 1  

E-Print Network (OSTI)

Construction of Anatomically Correct Models of Mouse Brain Networks 1 B. H. McCormick a, W. Koh a Y and Public Health, Texas A&M University, 4458 TAMU, College Station, TX 77843-4458 Abstract The Mouse Brain Web, a federated database, provides for the construction of anatomically correct models of mouse brain

Choe, Yoonsuck

333

ORIGINAL ARTICLE Early Brain Overgrowth in Autism Associated  

E-Print Network (OSTI)

ORIGINAL ARTICLE Early Brain Overgrowth in Autism Associated With an Increase in Cortical Surface, PhD; Chad Chappell, MA; Rachel Gimpel Smith, BA; Clement Vachet, MS; Joseph Piven, MD Context: Brain. Objective: To investigate early growth trajectories in brain volume and cortical thickness. Design

Utah, University of

334

The brain near the edge Dante R. Chialvo  

E-Print Network (OSTI)

The brain near the edge Dante R. Chialvo Department of Physiology, Feinberg Medical School grain, the brain seems a relatively small dynamical system composed by a few dozen interacting areas that some of the most fundamental properties of the functioning brain are possible because

Chialvo, Dante R.

335

UNSUPERVISED SEGMENTATION FOR AUTOMATIC DETECTION OF BRAIN TUMORS IN MRI  

E-Print Network (OSTI)

UNSUPERVISED SEGMENTATION FOR AUTOMATIC DETECTION OF BRAIN TUMORS IN MRI A.S. Capelle, O. Alata, C- thod for magnetic resonance images. The aim of this seg- mentation is to divide the brain a pre-segmentation to ex- tract the brain from the head. Then, a second segmentation is done inside

Lefèvre, Sébastien

336

Introduction The vertebrate brain has a characteristic and complex three-  

E-Print Network (OSTI)

2057 Introduction The vertebrate brain has a characteristic and complex three- dimensional structure, the development of which is not well understood. Brain morphogenesis begins during, and continues subsequent to, neural tube closure. One aspect of brain structure that is highly conserved throughout

Lowery, Laura Anne

337

XRDS summer 2010 Vol .16 No.442 From Brains  

E-Print Network (OSTI)

XRDS · summer 2010 · Vol .16 · No.442 From Brains to Bytes Although most people are likely all-powerful, BCI research. In the past year, University of Wisconsin-Madison's Brain-Twitter in- terface received Time Magazine's honor as the no. 9 invention of the year. Fur- thermore, as brain

Jacob, Robert J.K.

338

ELSEVIER Brain Research 712 (1996) 293-298 Research report  

E-Print Network (OSTI)

BRAIN RESEARCH ELSEVIER Brain Research 712 (1996) 293-298 Research report Local infusion of brain examined the effects of local infusion of BDNF on the electrophysioiogical activity of serotonergic neurons in the rat dorsal raph6 nucleus with extracellular single unit recording in vivo. Compared with vehicle-infused

Tepper, James M.

339

Scale-Free Brain Functional Networks Victor M. Eguiluz,1  

E-Print Network (OSTI)

Scale-Free Brain Functional Networks Victor M. Egui´luz,1 Dante R. Chialvo,2 Guillermo A. Cecchi,3 is used to extract functional networks connecting correlated human brain sites. Analysis of the resulting-world networks, reflect important functional information about brain states. DOI: 10.1103/PhysRevLett.94

Oro, Daniel

340

COMBINATION OF BRAIN CONFORMAL MAPPING AND LANDMARKS: A VARIATIONAL APPROACH  

E-Print Network (OSTI)

COMBINATION OF BRAIN CONFORMAL MAPPING AND LANDMARKS: A VARIATIONAL APPROACH Yalin Wang Mathematics brain data, data from multiple subjects are typically mapped into a canonical space. One method to do be mapped conformally to a sphere. Since the cortical surface of the brain is a genus zero surface, con

Wang, Yalin

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Analyzing 3D Images of the Brain NICHOLAS AYACHE  

E-Print Network (OSTI)

Analyzing 3D Images of the Brain NICHOLAS AYACHE OVERVIEW During the past 5 years, there has been research. Along these lines, and focusing on 3D images of the brain obtained with CT, MRI, SPECT, and PET for an objective analysis of 3D images of the brain. Such methods include segmentation, shape analysis, rigid

Paris-Sud XI, Université de

342

Perinatal Undernutrition: Accumulation of Catecholamines in Rat Brain  

E-Print Network (OSTI)

of the pregnant· rats consumed food containing 8 per- cent protein: half were fed 24 percent protein (6). ThusPerinatal Undernutrition: Accumulation of Catecholamines in Rat Brain Abstract. Brains of rats in the brains of rats (2) and children (3). This decrease could reflect changes in the number of neurons

Wurtman, Richard

343

Abstract B17: Health disparities in brain cancer incidence  

Science Journals Connector (OSTI)

...GA Abstract B17: Health disparities in brain cancer incidence Emanuela Taioli 1 Wenqi...reported that US black patients have lower brain cancer rates than whites, and this has...Gregory J. Riggins. Health disparities in brain cancer incidence. [abstract]. In...

Emanuela Taioli; Wenqi Gan; Gregory J. Riggins

2014-11-01T23:59:59.000Z

344

Facing the Future of Brain Tumor Clinical Research  

Science Journals Connector (OSTI)

...editorial CCR Focus Facing the Future of Brain Tumor Clinical Research Mark R. Gilbert...findings from genomic investigations of brain tumors to improve diagnosis, clinical...of the application of immunotherapy to brain tumors by key investigators in this field...

Mark R. Gilbert; Terri S. Armstrong; Whitney B. Pope; Martin J. van den Bent; Patrick Y. Wen

2014-11-15T23:59:59.000Z

345

Temporary blood?brain barrier disruption via focused ultrasound for targeted drug delivery in the brain  

Science Journals Connector (OSTI)

The ability to deliver drugs to the central nervous system is severely limited by the presence of the blood?brain barrier (BBB). This barrier normally serves to protect the brain and restricts the passage of most molecules from being delivered to the brain tissue from the blood stream. We have developed a method by which the BBB is temporarily disrupted in localized regions using low?power ultrasound pulses combined with a circulating ultrasound contrast agent. By systematically focusing at multiple overlapping locations one could prescribe the region in which the BBB is disrupted to conform to a desired target volume reducing drug penetration to the rest of the brain.Ultrasound parameters suited for this procedure are compatible with a device that can focus through the intact skull. In this presentation we will describe recent research on this technique discussing methodology safety possible mechanisms and potential means to guide and monitor the procedure.

Nathan McDannold

2007-01-01T23:59:59.000Z

346

The Relationship Between Brain Edema, Energy Metabolism, Glucose Content and rCBF Investigated by Artificial Brain Abscess in Cats  

Science Journals Connector (OSTI)

We developed the model of artificial brain abscess in cats to investigate quantitatively different forms of conservative management of acute brain abscess. First we compared antibiotic therapy alone with a com...

H. W. Bothe; Th. Wallenfang; A. Khalifa…

1982-01-01T23:59:59.000Z

347

In: Proceedings of SPIE Conference on Medical Imaging (4684), pp. 201-205, Feb. 2002. Robustness of the Brain Parenchymal Fraction for Measuring Brain  

E-Print Network (OSTI)

of the Brain Parenchymal Fraction for Measuring Brain Atrophy M. Stella Atkins, Jeff J. Orchard, Ben Law ABSTRACT Other researchers have proposed that the brain parenchymal fraction (or brain atrophy) may considers various factors influencing the measure of the brain parenchymal fraction obtained from dual spin

Orchard, Jeffery J.

348

1/12/11 1:51 PMComputer-Aided Brains: Scientific American Page 1 of 3http://www.scientificamerican.com/article.cfm?id=computer-aided-brains  

E-Print Network (OSTI)

ďż˝ Scientific American Mind ďż˝ October 2005 Head Lines | Mind & Brain Computer-Aided Brains By Brad Stenger1/12/11 1:51 PMComputer-Aided Brains: Scientific American Page 1 of 3http://www.scientificamerican.com/article.cfm?id=computer-aided-brains Image: For years, innovators have tried to devise computerized gadgetry to aid the brain. Advances have

Salvucci, Dario D.

349

E-Print Network 3.0 - analyzing occupational injuries Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

Laboratory's occupational medicine office are analyzed to reduce and... injuries. Ergonomics--The Science of Fitting the Job to the Worker From the work bench to the garden......

350

E-Print Network 3.0 - acute knee injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

planting and cutting, straight knee landings, and rapid, 1-step stops (Mc... and ankle. Lower extremity positioning at the time of injury often includes relatively low hip...

351

E-Print Network 3.0 - attenuates renal injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

of acute renal injury (bilateral ischemia) to show that vimentin reexpression favors... (Vim mice) and an experimental model of ... Source: Federici, Pierre - Laboratoire...

352

E-Print Network 3.0 - ameliorates renal injury Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

of acute renal injury (bilateral ischemia) to show that vimentin reexpression favors... (Vim mice) and an experimental model of ... Source: Federici, Pierre - Laboratoire...

353

E-Print Network 3.0 - aspirin-induced gastric injury Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

mucosa during angiogenic response to ethanol injury', Am. J... stages of gastric cancer Le Lu, Yanda Li and Shao Li* MOE Key Laboratory of Bioinformatics... in different...

354

E-Print Network 3.0 - acetaminophen-induced liver injury Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: , Pohl LR. Pathogenic role of natural killer T and natural...

355

E-Print Network 3.0 - alcohol-induced liver injury Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: Diverse Roles of Invariant Natural Killer T Cells in Liver...

356

E-Print Network 3.0 - abrogating liver injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: Diverse Roles of Invariant Natural Killer T Cells in Liver...

357

E-Print Network 3.0 - attenuates hepatocellular injury Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: Diverse Roles of Invariant Natural Killer T Cells in Liver...

358

E-Print Network 3.0 - attenuates liver injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: Diverse Roles of Invariant Natural Killer T Cells in Liver...

359

E-Print Network 3.0 - acute liver injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: NKT-deficient mice are more susceptible to carbon...

360

E-Print Network 3.0 - alcoholic liver injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: of a variety of liver disorders,16 including viral...

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Brain Uptake of a Fluorescent Vector Targeting the Transferrin Receptor: A Novel Application of in Situ Brain Perfusion  

Science Journals Connector (OSTI)

Brain Uptake of a Fluorescent Vector Targeting the Transferrin Receptor: A Novel Application of in Situ Brain Perfusion ... Next, brains were collected and transferred into ice-cold 0.1 M PBS, where cerebellum, meninges, brain stem, and large superficial blood vessels were removed. ... Using the in situ brain perfusion technique, we showed that GF120918 (dual inhibitor of Abcb1 and Abcg2) strongly enhanced the uptake (Clup, ?l/g/s) of [3H] A?1-40 by the brains of Abcb1-deficient mice, but not by the brains of Abcb1/Abcg2-deficient mice, suggesting that Abcg2 is involved in the transport of A? at the mouse BBB. ...

Wael Alata; Sarah Paris-Robidas; Vincent Emond; Fanchon Bourasset; Frédéric Calon

2013-11-11T23:59:59.000Z

362

Abstract 4592: Etirinotecan pegol accumulates in breast cancer brain metastases and prolongs survival in an experimental model of brain metastases of human triple negative breast cancer  

Science Journals Connector (OSTI)

...Etirinotecan pegol accumulates in breast cancer brain metastases and prolongs survival in an experimental model of brain metastases of human triple negative breast...Morgantown, WV. Background: Breast cancer brain metastases (BCBM) remain a challenging...

Mohamed Nounou; Ute Hoch; Chris E. Adkins; Tori B. Terrell; Heidi Villalba; Michael E. Eldon; Paul R. Lockman

2014-10-01T23:59:59.000Z

363

Abstract 642: Transcend, a protein vector for brain delivery, allows trastuzumab to reach the brain at effective concentration after incorporation to form BT2111  

Science Journals Connector (OSTI)

...Abstract 642: Transcend, a protein vector for brain delivery, allows trastuzumab to reach the brain at effective concentration after incorporation...patients eventually succumb to metastases of the brain because the endothelial tight junctions of...

Reinhard Gabathuler; Timothy Z. Vitalis; Mohamed I. Nounou; Chris E. Adkins; Paul R. Lockman; Wilfred A. Jefferies

2014-10-01T23:59:59.000Z

364

Abstract 1024: T11TS impedes glioma angiogenesis by attenuating brain endothelial Angiopoietin-1/Tie2 signaling and inducing apoptosis of glioma associated brain endothelial cells  

Science Journals Connector (OSTI)

...impedes glioma angiogenesis by attenuating brain endothelial Angiopoietin-1/Tie2 signaling...inducing apoptosis of glioma associated brain endothelial cells Debanjan Bhattacharya...Malignant gliomas are highly invasive primary brain tumors resistant to conventional treatments...

Debanjan Bhattacharya; Suhnrita Chaudhuri; Swapna Chaudhuri

2014-10-01T23:59:59.000Z

365

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer  

Science Journals Connector (OSTI)

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer ... NIR fluorescence images of the dissected brains were obtained using the Xenogen IVIS spectrum imager (Caliper Life Sciences, Inc., Hopkinton, MA). ... Immunohistochemical and morphometric analyses demonstrate that the density of blood vessels within experimental metastases in brains of mice or in clinical specimen of human lung cancer brain metastases is lower than that in the adjacent tumor-free brain parenchyma. ...

Jason Li; Ping Cai; Alireza Shalviri; Jeffrey T. Henderson; Chunsheng He; Warren D. Foltz; Preethy Prasad; Peter M. Brodersen; Yonghong Chen; Ralph DaCosta; Andrew Michael Rauth; Xiao Yu Wu

2014-10-13T23:59:59.000Z

366

Off-the-Job Injuries are on the Rise- and Costly  

Energy.gov (U.S. Department of Energy (DOE))

Do you have an off-the-job safety program? Should you? The findings from a National Safety Council survey suggest that off-the-job injuries cost companies and society in general as much, if not more than on-the-job injuries!

367

Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats  

E-Print Network (OSTI)

Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats in male Wistar rats. Cardioprotection was assessed by measuring elecrocardiographic (EKG), serum lactate-induced myo- cardial ischaemic injury in rats. This study provides a preliminary confirmation of the efficacy

Hammock, Bruce D.

368

Ergonomics and Musculoskeletal Injuries in Agriculture: Recognizing and Preventing the Industry's Most Widespread Health and Safety Problem  

E-Print Network (OSTI)

Ergonomics and Musculoskeletal Injuries in Agriculture: Recognizing and Preventing the Industry demonstrated that these potentially permanently disabling injuries are readily prevented using ergonomics that agricultural work is diverse and so agricultural ergonomics must bridge many specific problems with a flexible

Leistikow, Bruce N.

369

MAPPING THE ANKLE JOINTS PASSIVE MOTION AND MEASURING THE EFFECT OF INJURY ON LIGAMENT CONSTRAINT AT THE ANKLE JOINT  

E-Print Network (OSTI)

Lateral ankle sprain is one of the most common sports injuries, and having a better understanding of how ligament constraint changes after injury can assist in accurately diagnosing ankle laxity, prevention, and recovery. The objective was to map...

West III, James E.

2011-02-04T23:59:59.000Z

370

Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury  

E-Print Network (OSTI)

The activation of inflammatory responses, while critical for host defense, contributes to hepatic injury in numerous acute and chronic liver disease states as well as drug-induced liver injury (DILI). The interactions that ...

Raczynski, Arkadiusz R. (Arkadiusz Roland)

2011-01-01T23:59:59.000Z

371

Memory Function Before and After Whole Brain Radiotherapy in Patients With and Without Brain Metastases  

SciTech Connect

Purpose: To prospectively compare the effect of prophylactic and therapeutic whole brain radiotherapy (WBRT) on memory function in patients with and without brain metastases. Methods and Materials: Adult patients with and without brain metastases (n = 44) were prospectively evaluated with serial cognitive testing, before RT (T0), after starting RT (T1), at the end of RT (T2), and 6-8 weeks (T3) after RT completion. Data were obtained from small-cell lung cancer patients treated with prophylactic cranial irradiation, patients with brain metastases treated with therapeutic cranial irradiation (TCI), and breast cancer patients treated with RT to the breast. Results: Before therapy, prophylactic cranial irradiation patients performed worse than TCI patients or than controls on most test scores. During and after WBRT, verbal memory function was influenced by pretreatment cognitive status (p < 0.001) and to a lesser extent by WBRT. Acute (T1) radiation effects on verbal memory function were only observed in TCI patients (p = 0.031). Subacute (T3) radiation effects on verbal memory function were observed in both TCI and prophylactic cranial irradiation patients (p = 0.006). These effects were more pronounced in patients with above-average performance at baseline. Visual memory and attention were not influenced by WBRT. Conclusions: The results of our study have shown that WBRT causes cognitive dysfunction immediately after the beginning of RT in patients with brain metastases only. At 6-8 weeks after the end of WBRT, cognitive dysfunction was seen in patients with and without brain metastases. Because cognitive dysfunction after WBRT is restricted to verbal memory, patients should not avoid WBRT because of a fear of neurocognitive side effects.

Welzel, Grit [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany)], E-mail: grit.welzel@radonk.ma.uni-heidelberg.de; Fleckenstein, Katharina [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany); Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Schaefer, Joerg; Hermann, Brigitte; Kraus-Tiefenbacher, Uta; Mai, Sabine K.; Wenz, Frederik [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany)

2008-12-01T23:59:59.000Z

372

DOE-Flex Bulletin-Worker Injury While on a DOE-Flex Arrangement |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DOE-Flex Bulletin-Worker Injury While on a DOE-Flex Arrangement DOE-Flex Bulletin-Worker Injury While on a DOE-Flex Arrangement DOE-Flex Bulletin-Worker Injury While on a DOE-Flex Arrangement This bulletin responds to questions that have surfaced regarding DOE's liability for an injury to an employee while working at an alternative workplace, particularly at home. It is the position of the DOE Office of General Council that the case decision cited in this document should be relied upon as the prevailing administrative law at this time. DOE-Flex Bulletin-Worker Injury While on a DOE-Flex Arrangement Responsible Contacts Bruce Murray HR Policy Advisor E-mail bruce.murray@hq.doe.gov Phone 202-586-3372 More Documents & Publications Desk Reference on DOE-Flex The American Recovery and Reinvestment Act (ARRA) Energy Assurance Planning

373

Human immunodeficiency virus type 1 infection of the brain.  

Science Journals Connector (OSTI)

...NMDA antagonist, 1-amino-3,5-dimethyladamantine (Memantine), could block the toxicity of gpl20 (219). Antagonists...London) 330: 658-659. 219. Lipton, S. A. 1992. Memantine prevents HIV coat protein- induced neuronal injury in vitro...

W J Atwood; J R Berger; R Kaderman; C S Tornatore; E O Major

1993-10-01T23:59:59.000Z

374

Automatic Scan Prescription for Brain MRI T. Ernst, L. Itti, L. Chang  

E-Print Network (OSTI)

Automatic Scan Prescription for Brain MRI T. Ernst, L. Itti, L. Chang Harbor-UCLA Medical Center that allows the automatic prescription of brain MRI scans. This involves determination of the orientation of the current patient's brain, by matching his/her brain surface with a template brain surface. A desired

Itti, Laurent

375

Study of the brain connectivity in an Immersive Space Anne-Charlotte Philippe  

E-Print Network (OSTI)

Study of the brain connectivity in an Immersive Space Anne-Charlotte Philippe ATHENA/INRIA Sophia of the brain connectivity. Both anatomical and functional data are attached to a mesh representing the brain the experience of the visualization of brain meshes in an immersive space for the specific study of brain con

Paris-Sud XI, Université de

376

Complex Networks - A Key to Understanding Brain Function  

ScienceCinema (OSTI)

The brain is a complex network of neurons, engaging in spontaneous and evoked activity that is thought to be the main substrate of mental life.  How this complex system works together to process information and generate coherent cognitive states, even consciousness, is not yet well understood.  In my talk I will review recent studies that have revealed characteristic structural and functional attributes of brain networks, and discuss efforts to build computational models of the brain that are informed by our growing knowledge of brain anatomy and physiology.

Olaf Sporns

2010-01-08T23:59:59.000Z

377

A Case of Acquired Stuttering Following Brain Damage  

Science Journals Connector (OSTI)

Whilst neurogenic stuttering is by now a well-recognized nosological ... , this volume). A case of acquired stuttering following brain damage sustained in adulthood is...

H. Bijleveld; A.-M. Simon

1997-01-01T23:59:59.000Z

378

Brain-Computer Interface Control of an Anthropomorphic Robotic Arm.  

E-Print Network (OSTI)

??This thesis describes a brain-computer interface (BCI) system that was developed to allow direct cortical control of 7 active degrees of freedom in a robotic… (more)

Clanton, Samuel T.

2011-01-01T23:59:59.000Z

379

COLLOQUIUM: Consciousness and the Social Brain | Princeton Plasma...  

NLE Websites -- All DOE Office Websites (Extended Search)

4:00pm to 5:30pm Colloquia MBG Auditorium COLLOQUIUM: Consciousness and the Social Brain Professor Michael Graziano Princeton University Presentation: Presentation What is...

380

Multifractal Detrended Fluctuation Analysis Shows Promise For Brain Tumor Grading  

Science Journals Connector (OSTI)

This work proposes a novel non-invasive method for brain tumor grading using magnetic resonance imaging (MRI). Multifractal Detrended Fluctuation Analysis (MFDFA) [1] provides features...

Reza, Syed; Mays, Randall; Iftekharuddin, Khan M

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Chaotic physics in ferroelectrics hints at brain-like computing...  

NLE Websites -- All DOE Office Websites (Extended Search)

Oak Ridge National Laboratory 865-574-7308 Chaotic physics in ferroelectrics hints at brain-like computing Unexpected behavior in ferroelectric materials explored by researchers...

382

Methodology and Techniques for Building Modular Brain-Computer Interfaces.  

E-Print Network (OSTI)

??Commodity brain-computer interfaces (BCI) are beginning to accompany everything from toys and games to sophisticated health care devices. These contemporary interfaces allow for varying levels… (more)

Cummer, Jason

2015-01-01T23:59:59.000Z

383

Beneath the surface: The decline in gender injury gap  

Science Journals Connector (OSTI)

Abstract Gender differences in the labor market are typically measured by the wage gap. In this paper, we investigate how extending the analysis to an additional job amenity, namely workplace safety, may shed new light on the evolution of gender differences. Our results show that focusing on one unique measure of the gender gap may provide a biased view of the actual progress of women in the labor market. In our data, a significant reduction in the wage gap has been accompanied by a relative increase in injury risk for some groups of workers, e.g. low-skilled female workers. The decreased gender wage gap for these workers does not necessarily imply an overall improvement in their labor market outcomes.

Tiziano Razzolini; Roberto Leombruni; Giovanni Mastrobuoni; Mario Pagliero

2014-01-01T23:59:59.000Z

384

Positron Scanner for Locating Brain Tumors  

DOE R&D Accomplishments (OSTI)

A system is described that makes use of positron emitting isotopes for locating brain tumors. This system inherently provides more information about the distribution of radioactivity in the head in less time than existing scanners which use one or two detectors. A stationary circular array of 32 scintillation detectors scans a horizontal layer of the head from many directions simultaneously. The data, consisting of the number of counts in all possible coincidence pairs, are coded and stored in the memory of a Two-Dimensional Pulse-Height Analyzer. A unique method of displaying and interpreting the data is described that enables rapid approximate analysis of complex source distribution patterns. (auth)

Rankowitz, S.; Robertson, J. S.; Higinbotham, W. A.; Rosenblum, M. J.

1962-03-00T23:59:59.000Z

385

Brain micro-ecologies: neural stem cell niches in the adult mammalian brain  

Science Journals Connector (OSTI)

...repair compiled by Siddharthan Chandran, Maeve Caldwell and Nick Allen Brain micro-ecologies: neural stem cell niches in the...How these molecules and others yet to be identified interact merits further study. 5. Vasculature and adult neural stem cell niches...

2008-01-01T23:59:59.000Z

386

Erratum to: S100B as a Marker for Brain Damage and Blood–Brain Barrier Disruption Following Exercise  

Science Journals Connector (OSTI)

...51. Vogelbaum MA, Masaryk T, Mazzone P, et al. S100? as a predictor of brain metastases. Cancer. 2005;15(104):817...

Serene X. T. Koh; Jason K. W. Lee

2014-06-01T23:59:59.000Z

387

Brief Introduction to BrainSpace V2.1 BrainSpace V2.1: Geometric mapping and diffusion-based software for  

E-Print Network (OSTI)

1 Brief Introduction to BrainSpace V2.1 BrainSpace V2.1: Geometric mapping and diffusion-based software for cross-subject multimodality brain imaging informatics Graphics and Imaging Laboratory Wayne for advanced and integrated analysis of brain imaging data. It is expected that the developed, advanced

Hua, Jing

388

Brain as quantum-like computer  

E-Print Network (OSTI)

We present a contextualist statistical realistic model for quantum-like representations in physics, cognitive science and psychology. We apply this model to describe cognitive experiments to check quantum-like structures of mental processes. The crucial role is played by interference of probabilities for mental observables. Recently one of such experiments based on recognition of images was performed. This experiment confirmed our prediction on quantum-like behaviour of mind. In our approach ``quantumness of mind'' has no direct relation to the fact that the brain (as any physical body) is composed of quantum particles. We invented a new terminology ``quantum-like (QL) mind.'' Cognitive QL-behaviour is characterized by nonzero coefficient of interference $\\lambda.$ This coefficient can be found on the basis of statistical data. There is predicted not only $\\cos \\theta$-interference of probabilities, but also hyperbolic $\\cosh \\theta$-interference. This interference was never observed for physical systems, but we could not exclude this possibility for cognitive systems. We propose a model of brain functioning as QL-computer (there is discussed difference between quantum and QL computers).

Andrei Khrennikov

2005-03-24T23:59:59.000Z

389

The Brain, Seizures and Epilepsy Throughout Life: Understanding a Moving Target  

E-Print Network (OSTI)

SL. Why is the developing brain more susceptible to statusand relationship to epilepsy. Brain Dev 2009;31:366–371. 46.child, adult, and aging brain is crucial for optimal

Baram, Tallie Z.

2012-01-01T23:59:59.000Z

390

Do smart birds stress less? An interspecific relationship between brain size and corticosterone levels  

Science Journals Connector (OSTI)

...An interspecific relationship between brain size and corticosterone levels adam Z...report that in birds, species with larger brains relative to their body size show lower...CORT levels than species with smaller brains. This relationship is consistent across...

2013-01-01T23:59:59.000Z

391

Importance of the matriline for genomic imprinting, brain development and behaviour  

Science Journals Connector (OSTI)

...the matriline for genomic imprinting, brain development and behaviour E. B. Keverne...epigenetics in biology and medicine . Mammalian brain development commences during foeto-placental...part, be epigenetic mediators of such brain diversity. Interestingly some imprinted...

2013-01-01T23:59:59.000Z

392

Model-driven therapeutic treatment of neurological disorders: reshaping brain rhythms with neuromodulation  

Science Journals Connector (OSTI)

...treatment of neurological disorders: reshaping brain rhythms with neuromodulation Julien Modolo...efficient, yet invasive treatment: deep brain stimulation (DBS). However, the efficiency...the complex relationship existing between brain processing and behaviour. Biophysical...

2011-01-01T23:59:59.000Z

393

Brain organization mirrors caste differences, colony founding and nest architecture in paper wasps (Hymenoptera: Vespidae)  

Science Journals Connector (OSTI)

...research-article Research articles 1001 42 14 133 Brain organization mirrors caste differences...social organization and may affect mosaic brain evolution. We asked whether the relative size of functionally distinct brain regions corresponds to species differences...

2009-01-01T23:59:59.000Z

394

Abstract 3714: Trametinib (Mekinist TM) has limited brain distribution in the mouse model  

Science Journals Connector (OSTI)

...Trametinib (Mekinist TM) has limited brain distribution in the mouse model Shruthi...molecularly-targeted agents into the brain. The discovery of focal BRAF mutations...vemurafenib and dabrafenib) have limited brain distribution due to active efflux at the...

Shruthi Vaidhyanathan; Rajendar K. Mittapalli; Daniel J. Ma; Mark A. Schroeder; Jann N. Sarkaria; William F. Elmquist

2014-10-01T23:59:59.000Z

395

Abstract 4876: Characterization of malignant melanoma growth triggered by the brain microenvironment in experimental metastasis models  

Science Journals Connector (OSTI)

...malignant melanoma growth triggered by the brain microenvironment in experimental metastasis...University Hospital, Oslo, Norway. The brain offers a unique microenvironment to which...molecular determinants that promote melanoma brain metastases however, remain largely unknown...

Vigdis Nygaard; Lina Prasmickaite; Kotryna Vasiliauskaite; Trevor Clancy; Eivind Hovig

2014-10-01T23:59:59.000Z

396

Treatment outcomes using CyberKnife for brain metastases from lung cancer  

Science Journals Connector (OSTI)

......Treatment outcomes using CyberKnife for brain metastases from lung cancer Keisuke Tamari...fractionated stereotactic radiotherapy (SRT) for brain metastases from lung cancer. A total of 67 patients with 109 brain metastases from lung cancer treated using......

Keisuke Tamari; Osamu Suzuki; Naoya Hashimoto; Naoki Kagawa; Masateru Fujiwara; Iori Sumida; Yuji Seo; Fumiaki Isohashi; Yasuo Yoshioka; Toshiki Yoshimine; Kazuhiko Ogawa

2014-10-01T23:59:59.000Z

397

Abstract 1295: The association between asthma and pediatric brain tumors in neurofibromatosis type 1  

Science Journals Connector (OSTI)

...association between asthma and pediatric brain tumors in neurofibromatosis type 1 Kimberly...several tumor types, including pediatric brain tumors that affect an estimated 10-20...established risk factors for pediatric brain tumor development in this population have...

Kimberly J. Johnson; Nancy Mueller; Evelyn Sharkey; Qian Liu; David H. Gutmann

2014-10-01T23:59:59.000Z

398

E-Print Network 3.0 - amusic brain lost Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

amusic brain lost Search Powered by Explorit Topic List Advanced Search Sample search results for: amusic brain lost Page: << < 1 2 3 4 5 > >> 1 The Amusic Brain: Lost in Music,...

399

E-Print Network 3.0 - adult mammalian brain Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: adult mammalian brain Page: << < 1 2 3 4 5 > >> 1 Hemby & Wn fE&) Progress In Brain...

400

E-Print Network 3.0 - automatic brain tumor Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

brain tumor Search Powered by Explorit Topic List Advanced Search Sample search results for: automatic brain tumor Page: << < 1 2 3 4 5 > >> 1 Registration of Brain Images With...

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

E-Print Network 3.0 - acquired brain damage Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

brain damage Search Powered by Explorit Topic List Advanced Search Sample search results for: acquired brain damage Page: << < 1 2 3 4 5 > >> 1 Focal brain damage protects against...

402

E-Print Network 3.0 - auditory brain-stem response Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

brain-stem response Search Powered by Explorit Topic List Advanced Search Sample search results for: auditory brain-stem response Page: << < 1 2 3 4 5 > >> 1 Brain Stem Response to...

403

E-Print Network 3.0 - adult human brain Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: adult human brain Page: << < 1 2 3 4 5 > >> 1 Hemby & Wn fE&) Progress In Brain RwureI.Vol....

404

How Does the Brain Learn to Read? Guest Lecture by James R. Booth  

E-Print Network (OSTI)

How Does the Brain Learn to Read? Guest Lecture by James R that general principles of brain development are key to reaching a deeper understanding) the specialization of brain regions for different computations and (2) the interaction between

Loudon, Catherine

405

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression  

Science Journals Connector (OSTI)

...2014 research-article Research Briefs Brain Tumor Cells in Circulation Are Enriched...Glioblastoma (GBM) is a highly aggressive brain cancer characterized by local invasion...GBM, uncovering evidence of circulating brain tumor cells (CTC). Staining and scoring...

James P. Sullivan; Brian V. Nahed; Marissa W. Madden; Samantha M. Oliveira; Simeon Springer; Deepak Bhere; Andrew S. Chi; Hiroaki Wakimoto; S. Michael Rothenberg; Lecia V. Sequist; Ravi Kapur; Khalid Shah; A. John Iafrate; William T. Curry; Jay S. Loeffler; Tracy T. Batchelor; David N. Louis; Mehmet Toner; Shyamala Maheswaran; Daniel A. Haber

2014-11-01T23:59:59.000Z

406

Monte Carlo simulation of quantum Zeno effect in the brain  

E-Print Network (OSTI)

Environmental decoherence appears to be the biggest obstacle for successful construction of quantum mind theories. Nevertheless, the quantum physicist Henry Stapp promoted the view that the mind could utilize quantum Zeno effect to influence brain dynamics and that the efficacy of such mental efforts would not be undermined by environmental decoherence of the brain. To address the physical plausibility of Stapp's claim, we modeled the brain using quantum tunneling of an electron in a multiple-well structure such as the voltage sensor in neuronal ion channels and performed Monte Carlo simulations of quantum Zeno effect exerted by the mind upon the brain in the presence or absence of environmental decoherence. The simulations unambiguously showed that the quantum Zeno effect breaks down for timescales greater than the brain decoherence time. To generalize the Monte Carlo simulation results for any n-level quantum system, we further analyzed the change of brain entropy due to the mind probing actions and proved a theorem according to which local projections cannot decrease the von Neumann entropy of the unconditional brain density matrix. The latter theorem establishes that Stapp's model is physically implausible but leaves a door open for future development of quantum mind theories provided the brain has a decoherence-free subspace.

Danko Georgiev

2014-12-11T23:59:59.000Z

407

Topic 14 -Stroke 1. Blood supply to the brain  

E-Print Network (OSTI)

Topic 14 - Stroke 1. Blood supply to the brain 2. Types of stroke 3. Treatment of acute stroke Territories supplied by anterior, middle and posterior cerebral arteries. Topic 14 - Stroke 1. Blood supply to the brain 2. Types of stroke 3. Treatment of acute stroke #12;Stroke - a.k.a. "cerebrovascular accident

Sergio, Lauren E.

408

Characterization of a plasma membrane zinc transporter in rat brain  

E-Print Network (OSTI)

Ireland Ltd. Keywords: Ion transport; Membrane vesicles; Excitotoxicity; Zinc homeostasis; TransitionCharacterization of a plasma membrane zinc transporter in rat brain Robert A. Colvin* Department transport in the brain. This report provides convincing evidence of a zinc transporter in plasma membrane

409

Brain of the African Elephant (Loxodonta africana): Neuroanatomy  

E-Print Network (OSTI)

Brain of the African Elephant (Loxodonta africana): Neuroanatomy From Magnetic Resonance Images images of the brain of an adult Afri- can elephant, Loxodonta africana, in the axial and parasagittal ) and of the neocortical and cerebellar gray and white matter. The white matter-to-gray matter ratio in the elephant neo

Allman, John M.

410

A reaction-diffusion model of the human brain development  

Science Journals Connector (OSTI)

The anatomical variability of the human brain folds remains an unclear and challenging issue. Several hypotheses coexist for explaining the rapid development of cortical sulci and it is clear that understanding their variability would improve the comparison ... Keywords: brain development, folding, reaction-diffusion equations

Julien Lefčvre; Jean-François Mangin

2010-04-01T23:59:59.000Z

411

DISTRIBUTED, WEB-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE  

E-Print Network (OSTI)

DISTRIBUTED, WEB-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE A Thesis by WONRYULL KOH Submitted-BASED MICROSTRUCTURE DATABASE FOR BRAIN TISSUE A Thesis by WONRYULL KOH Submitted to Texas A&M University in partial) __________________________ Ian S. Russell (Member) __________________________ Wei Zhao (Head of Department

412

COMPUTATIONAL ROLE OF DISINHIBITION IN BRAIN FUNCTION A Dissertation  

E-Print Network (OSTI)

COMPUTATIONAL ROLE OF DISINHIBITION IN BRAIN FUNCTION A Dissertation by YINGWEI YU Submitted OF DISINHIBITION IN BRAIN FUNCTION A Dissertation by YINGWEI YU Submitted to the Office of Graduate Studies Takashi Yamauchi Head of Department, Valerie E. Taylor August 2006 Major Subject: Computer Science #12;iii

Choe, Yoonsuck

413

Deformable Organisms and Error Learning for Brain Segmentation  

E-Print Network (OSTI)

Deformable Organisms and Error Learning for Brain Segmentation Gautam Prasad1,2 , Anand A. Joshi3 be easily incorporated into the plan. We validate this framework by creating a plan to locate the brain in 3D magnetic resonance images of the head (skull-stripping). This is important for surgical planning

Boyer, Edmond

414

Patch-based Segmentation of Brain Tissues Nicolas Cordier1  

E-Print Network (OSTI)

Patch-based Segmentation of Brain Tissues Nicolas Cordier1 , Bjoern Menze1,2 , Herv´e Delingette1-channel patches. After patches are extracted from several MR channels for a test case, similar patches are found to these developed for human brain labelling in [1]. A database of multi-channel patches is first built from a set

Paris-Sud XI, Université de

415

E-Print Network 3.0 - astrocytic brain tumors Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

astrocytic brain tumors Search Powered by Explorit Topic List Advanced Search Sample search results for: astrocytic brain tumors Page: << < 1 2 3 4 5 > >> 1 This article appeared...

416

E-Print Network 3.0 - aerosolized brain natriuretic Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

brain natriuretic Search Powered by Explorit Topic List Advanced Search Sample search results for: aerosolized brain natriuretic Page: << < 1 2 3 4 5 > >> 1 JOURNAL OF EXPERIMENTAL...

417

E-Print Network 3.0 - activated brain microglia Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

brain microglia Search Powered by Explorit Topic List Advanced Search Sample search results for: activated brain microglia Page: << < 1 2 3 4 5 > >> 1 Juxtavascular Microglia...

418

E-Print Network 3.0 - assessing blood brain Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: assessing blood brain Page: << < 1 2 3 4 5 > >> 1 The University of Western Ontario...

419

E-Print Network 3.0 - asphyxia induced brain Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

induced brain Search Powered by Explorit Topic List Advanced Search Sample search results for: asphyxia induced brain Page: << < 1 2 3 4 5 > >> 1 Abnormal cerebral haemodynamics in...

420

Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...  

NLE Websites -- All DOE Office Websites (Extended Search)

Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

E-Print Network 3.0 - abnormal brain connection Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Powered by Explorit Topic List Advanced Search Sample search results for: abnormal brain connection Page: << < 1 2 3 4 5 > >> 1 White Matter Abnormalities in Whole Brain and...

422

E-Print Network 3.0 - acquired developmental brain Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

developmental brain Search Powered by Explorit Topic List Advanced Search Sample search results for: acquired developmental brain Page: << < 1 2 3 4 5 > >> 1 GRAMMATICALITY...

423

E-Print Network 3.0 - artery simulating brain Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

simulating brain Search Powered by Explorit Topic List Advanced Search Sample search results for: artery simulating brain Page: << < 1 2 3 4 5 > >> 1 in Research Clinical and...

424

E-Print Network 3.0 - acetazolamide stress brain Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

stress brain Search Powered by Explorit Topic List Advanced Search Sample search results for: acetazolamide stress brain Page: << < 1 2 3 4 5 > >> 1 doi:10.1152...

425

E-Print Network 3.0 - ameliorates fractionated whole-brain Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

fractionated whole-brain Search Powered by Explorit Topic List Advanced Search Sample search results for: ameliorates fractionated whole-brain Page: << < 1 2 3 4 5 > >> 1...

426

E-Print Network 3.0 - abnormal brain processing Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Powered by Explorit Topic List Advanced Search Sample search results for: abnormal brain processing Page: << < 1 2 3 4 5 > >> 1 White Matter Abnormalities in Whole Brain and...

427

E-Print Network 3.0 - adult rat brain Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: adult rat brain Page: << < 1 2 3 4 5 > >> 1 Damageduring prenataldevelopmentof certainbrain...

428

E-Print Network 3.0 - alzheimers disease brain Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: alzheimers disease brain Page: << < 1 2 3 4 5 > >> 1 Understanding Alzheimer's Disease...

429

Spatial Mapping of Protein Abundances in the Mouse Brain by Voxelation...  

NLE Websites -- All DOE Office Websites (Extended Search)

Mapping of Protein Abundances in the Mouse Brain by Voxelation Integrated with High-Throughput Liquid Chromatography Spatial Mapping of Protein Abundances in the Mouse Brain by...

430

E-Print Network 3.0 - attenuate postischemic brain Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

postischemic brain Search Powered by Explorit Topic List Advanced Search Sample search results for: attenuate postischemic brain Page: << < 1 2 3 4 5 > >> 1 Permanent Reduction of...

431

E-Print Network 3.0 - adult drosophila brain Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: adult drosophila brain Page: << < 1 2 3 4 5 > >> 1 Neuroscience Letters (1979) S. 132...

432

E-Print Network 3.0 - activate brain sulfonylurea-sensitive Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

brain sulfonylurea-sensitive Search Powered by Explorit Topic List Advanced Search Sample search results for: activate brain sulfonylurea-sensitive Page: << < 1 2 3 4 5 > >> 1...

433

E-Print Network 3.0 - approach demonstrates brain Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

demonstrates brain Search Powered by Explorit Topic List Advanced Search Sample search results for: approach demonstrates brain Page: << < 1 2 3 4 5 > >> 1 STATISTICS SEMINAR...

434

Towards the study of functional brain development in depression: An Interactive Specialization approach  

E-Print Network (OSTI)

University in St. Louis, Saint Louis, MO, USA c The Edward Mallinckrodt Institute of Radiology, Washington: Depression Brain Brain development Interactive Specialization Preschool depression Pediatric depression

Wang, Yan Mei

435

Rick Grush Brain time and phenomenological time (draft) Page 1/37 Brain time and phenomenological time  

E-Print Network (OSTI)

Rick Grush Brain time and phenomenological time (draft) Page 1/37 Brain time and phenomenological "forthwith" in a common structure. - Edmund Husserl, Phenomenology of Inner Time Consciousness1 1 time and phenomenological time (draft) Page 2/37 information-processing structure that accounts

Grush, Rick

436

Surveillance Guide - OSS 19.11 Injury and Illness Record Keeping  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

INJURY AND ILLNESS RECORDKEEPING INJURY AND ILLNESS RECORDKEEPING 1.0 Objective The objective of this surveillance is to evaluate the contractor's process for identifying and recording data pertaining to occupational injuries and illnesses. The Facility Representative will benchmark the existing records regarding injuries and illnesses, against the source data maintained by individual field medical facilities. In addition, the Facility Representative will evaluate the contractor's compliance with the Department of Energy's (DOE) key requirements. 2.0 References 2.1 DOE N 231.1, Environmental, Safety and Health Reporting Notice 2.2 DOE M 231.1, Environmental, Safety, and Health Reporting Manual 2.3 DOE Order 440.1A "Worker Protection Management for

437

Identification and molecular characterization of novel genomic targets in oxidant-induced vascular injury  

E-Print Network (OSTI)

Gene expression was examined in vascular smooth muscle cells to study the complex interaction between oxidative injury and the pathogenesis of vascular disease. Extensive vascular remodeling coupled to increased production of 8-epi-PGF2�± nuclear...

Partridge, Charles Randal

2007-04-25T23:59:59.000Z

438

UCDavis // Dept. Biomedical Engineering // IIPP i NOV. 2014 Injury & Illness Prevention  

E-Print Network (OSTI)

UCDavis // Dept. Biomedical Engineering // IIPP i NOV. 2014 Injury & Illness Prevention Program Department of Biomedical Engineering Updated November, 2014 #12;UCDavis // Dept. Biomedical Engineering // IIPP ii NOV. 2014 THIS PAGE INTENTIONALLY LEFT BLANK. #12;UCDavis // Dept. Biomedical Engineering

Rocke, David M.

439

UCDavis // Dept. Biomedical Engineering // IIPP i Oct 2013 Injury & Illness Prevention  

E-Print Network (OSTI)

UCDavis // Dept. Biomedical Engineering // IIPP i Oct 2013 Injury & Illness Prevention Program Department of Biomedical Engineering Updated October 24, 2013 #12;UCDavis // Dept. Biomedical Engineering // IIPP ii Oct 2013 THIS PAGE INTENTIONALLY LEFT BLANK. #12;UCDavis // Dept. Biomedical Engineering

Ferrara, Katherine W.

440

E-Print Network 3.0 - acute lung injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Collection: Biology and Medicine 56 1 6 0 ANNALS OF EMERGENCY MEDICINE 38:2 AUGUST 2001 METHODOLOGY Summary: patients with minor head injury (N1,702), (2) the prevalence of...

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

The Epidemiology and Injury Patterns of Acetabular Fractures: Are the USA and China Comparable?  

Science Journals Connector (OSTI)

Acetabular fractures are rare injuries in heterogeneous patient groups, making it difficult to develop adequately powered prospective single-center clinical trials in the USA or Europe. Chinese trauma centers ...

Cyril Mauffrey MD; FACS; FRCS…

2014-11-01T23:59:59.000Z

442

W. M. Keck Center for Collaborative Neuroscience THE SPINAL CORD INJURY PROJECT  

E-Print Network (OSTI)

W. M. Keck Center for Collaborative Neuroscience THE SPINAL CORD INJURY PROJECT THE MASCIS IMPACTOR model that is used in over 100 laboratories around the world. Most of the recommended procedures

Chen, Kuang-Yu

443

E-Print Network 3.0 - arm injuries Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

the Female Elbow Joint Summary: on the dummy forearm as a potential injury index for arm fracture (Saul, 1996). For the purpose of the present... 1 Upper Extremity Interaction...

444

Computational modeling of trabecular bone in lower extremity injuries due to impact  

E-Print Network (OSTI)

Lower extremity injuries resulting from improvised explosive devices (IEDs) pose a serious threat to the safety of military troops. Reports from Operation Iraqi Freedom and Operation Enduring Freedom identify IEDs as the ...

Pino, Wendy

2013-01-01T23:59:59.000Z

445

Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice  

Science Journals Connector (OSTI)

......device or a sophisticated nuclear weapon (nuclear bomb), or an attack on a nuclear power plant or nuclear waste facility. The most destructive scenario...treat victims of radiological or nuclear terrorism. Radiation combined injury is a term used......

Vijay K. Singh; Stephen Y. Wise; Oluseyi O. Fatanmi; Lindsay A. Beattie; Elizabeth J. Ducey; Thomas M. Seed

2014-01-01T23:59:59.000Z

446

E-Print Network 3.0 - acute tubular injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

EGF-R and its ligands are believed to play a pivotal role Summary: renal injury, infusion of EGF enhanced recovery from acute tubular necrosis (12, 13); (b... prolifera- tion,...

447

Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury  

E-Print Network (OSTI)

Acute kidney injury is a devastating syndrome that afflicts over 2,000,000 people in the US per year, with an associated mortality of greater than 70% in severe cases. Unfortunately, standard-of-care treatments are not ...

Milwid, John Miles

2012-01-01T23:59:59.000Z

448

Hypotension as a risk factor for acute kidney injury in ICU patients  

E-Print Network (OSTI)

In the context of critical illness, hypotension may be associated with acute kidney injury (AKI). Using the MIMIC II database, we studied the risk of AKI in ICU patients as a function of both the severity and duration of ...

Lehman, Li-Wei H.

449

Workers at Paducah Site Exceed 1.5 Million Hours Without Lost-Time Injury, Illness  

Energy.gov (U.S. Department of Energy (DOE))

PADUCAH, Ky. – Workers with Paducah site infrastructure contractor Swift & Staley, Inc. recently exceeded 1.5 million hours without lost time away from work due to injury or illness, representing nine years of safe performance.

450

E-Print Network 3.0 - attenuates lung injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

BIOLOGY CONTRIBUTION Summary: RESONANCE IMAGING OF RADIATION-INDUCED LUNG INJURY IN RATS ERIKA R. WARD, B.S.E.,* LAURENCE W. HEDLUND, PH... and evaluation of radiation-induced...

451

E-Print Network 3.0 - a-induced liver injury Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: J 18 mice are resistant to concanavalin A-induced and...

452

Prevent injuries and increase your performance with appropriate bicycle fitting, flexibility, stability  

E-Print Network (OSTI)

Prevent injuries and increase your performance with appropriate bicycle fitting, flexibility, stability and technique. Explore the interplay between bicycle position and body mechanics. Tests performed in the UC Davis Sports Medicine Laboratory include Bicycle Fitting, Torque Analysis and Physiological Tests

Schladow, S. Geoffrey

453

The role of stress in recovery of function after spinal cord injury  

E-Print Network (OSTI)

of function and chronic pain associated with spinal cord injury (Elliot & Frank, 1996). On average, these individuals exhibit less function than non-depressed patients. The reason for this may be motivational, however recent research from our laboratory... following injury, contributing to the number of fibers that undergo Wallerian degeneration in the first 6 months (Crowe et al., 1997; Grossman, Rosenberg, & Wrathall, 2001; Li et al., 1999; Schwab & Bartholdi, 1996; Shuman, Bresnahan, & 7 Beattie, 1997...

Washburn, Stephanie Nicole

2009-05-15T23:59:59.000Z

454

Comparative Evaluation of Four Presumptive Tests for Blood to Detect Epithelial Injury on Fish  

SciTech Connect

Current methods of fish epithelial injury detection are limited to gross macroscopic examination that has a subjective bias as well as an inability to reliably quantify the degree of injury. Fluorescein, a presumptive test for blood, has been shown to have the capability to detect and quantify fish epithelial injury. However, there are several other presumptive tests for blood (Bluestar*, phenolphthalein, and HemastixH) that may have benefits over the use of fluorescein, particularly for field research on wild fish. This study investigated the capabilities of these four tests to detect and quantify a variety of injuries commonly encountered by fish (abrasion, cuts, fin frays, and punctures) using the freshwater bluegill Lepomis macrochirus as a model. Fluorescein was consistently found to be the most reliable (i.e., detected the highest proportion of true positive results and rarely detected false positive reactions) of the four presumptive tests for blood compared. Further testing was conducted to examine the reliability of fluorescein. By 24 h after an injury was inflicted, the injury was no longer detectable by fluorescein, and when fluorescein was applied to an injured fish, the fluorescein was no longer detectable 3 h after application. In a comparison of two common anaesthetics used in fisheries research, there was no significant difference in the proportion of injury detected when 3- aminobenzoic acid ethyl ester methanesulfate (tricaine) was used compared with a clove oil and ethanol (1:9) solution. In summary, fluorescein was the most reliable presumptive test for blood examined in this study for the detection and quantification of recent (hours) fish epithelial injury.

Colotelo, Alison HA; Smokorowski, Karen; Haxton, Tim; Cooke, Steven J.

2014-06-01T23:59:59.000Z

455

Prevention of Torsion-induced Testicular Injury by Rhodiola rosea  

Science Journals Connector (OSTI)

Objective To evaluate the efficacy of Rhodiola rosea (R. rose) extract in terms of preventing tissue injury induced by testicular torsion and subsequent ischemia/reperfusion (I/R). Methods Twenty-one Wistar albino male rats were divided into 3 groups: group 1 = control group, group 2 = I/R group, and group 3 = I/R + extract group. After 2 hours of ischemia and 4 hours of reperfusion, testes were removed and evaluated histologically by hematoxylin and eosin staining. Apoptosis in spermatogonial cells of seminiferous tubules was determined by transferase biotin-2?-deoxyuridine, 5?-triphosphate nick end labeling (TUNEL). To assess oxidative damage, serum malondialdehyde (MDA) and glutathione (GSH) levels were measured. Results Median MDA and GSH levels were, respectively, 12 ± 3 pmol/mL and 24.8 ± 3.8 ?M in group 1, 38 ± 11 pmol/mL and 10.3 ± 1.7 ?M in group 2, and 19 ± 5 pmol/mL and 17.6 ± 1.3 ?M in group 3 (P merits further investigation.

Ugur Uyeturk; E. Hakan Terzi; Adnan Gucuk; Eray Kemahli; Hayrettin Ozturk; Mehmet Tosun

2013-01-01T23:59:59.000Z

456

Graph analysis of functional brain networks: practical issues in translational neuroscience  

Science Journals Connector (OSTI)

...Theme Issue Complex network theory and the brain compiled and edited by David Papo, Javier...Bullmore Graph analysis of functional brain networks: practical issues in translational...Theme Issue Complex network theory and the brain . The brain can be regarded as a network...

2014-01-01T23:59:59.000Z

457

BrainPrint in the Computer-Aided Diagnosis of Alzheimer's Disease  

E-Print Network (OSTI)

BrainPrint in the Computer-Aided Diagnosis of Alzheimer's Disease C. Wachinger1,2 , K cognitive impairment. We employ BrainPrint to obtain an extensive characterization of the shape of brain structures. BrainPrint captures shape information of an ensemble of cortical and subcortical structures

Golland, Polina

458

Quantitative diffusion magnetic resonance imaging of the brain : validation, acquisition, and analysis  

E-Print Network (OSTI)

Engineering, Magnetic Resonance Imaging, Cognitive Science.on magnetic resonance imaging applications in brain science.

White, Nathan S.

2010-01-01T23:59:59.000Z

459

Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins  

Science Journals Connector (OSTI)

Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins ...

Karen E. Carney; Marco Milanese; Pim van Nierop; Ka Wan Li; Stéphane H.R. Oliet; August B. Smit; Giambattista Bonanno; Mark H.G. Verheijen

2014-10-13T23:59:59.000Z

460

Composition and On Demand Deployment of Distributed Brain Activity Analysis Application on Global Grids  

E-Print Network (OSTI)

1 Composition and On Demand Deployment of Distributed Brain Activity Analysis Application on Global are brain science and high-energy physics. The analysis of brain activity data gathered from the MEG and analyze brain functions and requires access to large-scale computational resources. The potential platform

Abramson, David

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Negative Association of Neuroticism with Brain Volume Ratio in Healthy Humans  

E-Print Network (OSTI)

Negative Association of Neuroticism with Brain Volume Ratio in Healthy Humans Brian Knutson, Reza Momenan, Robert R. Rawlings, Grace W. Fong, and Daniel Hommer Background: Brain volume decreases reactivity (i.e., neuroti- cism) would also predict reductions in brain volume. Methods: Brain volume ratios

Knutson, Brian

462

Importance of exogenous saturated fatty acids during brain development and myelination in mice  

E-Print Network (OSTI)

Importance of exogenous saturated fatty acids during brain development and myelination in mice J. M origin of brain membranes is an impor- tant parameter in the synthesis of these membranes. After injection, labelled stearic acid was transported into the brain and incorporated into brain lipids

Boyer, Edmond

463

The Future of Brain Research From Molecules to Mind and Back  

E-Print Network (OSTI)

The Future of Brain Research From Molecules to Mind and Back: Comments for Discussion Yadin Dudai The Weizmann Institute of Science Privileged communication #12;Internal representations are: Tenets The brain of brain research: How are internal representations encoded and manipulated in the brain to result

Joskowicz, Leo

464

Functional Connectivity Magnetic Resonance Imaging Reveals Cortical Functional Connectivity in the Developing Brain  

E-Print Network (OSTI)

in the Developing Brain Weili Lin, Ph.D.^1 , Quan Zhu, M.S.^ 2 , Wei Gao, M.S.^ 3 , Yasheng Chen, D.Sc.^ 1 , Cheng was utilized to depict brain regions exhibiting temporal synchronization, also known as resting brain pixel-by-pixel throughout the entire brain, identifying regions with high temporal correlation. Results

Utah, University of

465

Binary and nonbinary description of hypointensity for search and retrieval of brain MR images  

E-Print Network (OSTI)

Binary and nonbinary description of hypointensity for search and retrieval of brain MR images. In a previous study based on binary description of hypointensity in the brain, it was shown that brain iron accumulation shape provides additional information to the shape-insensitive features, such as the total brain

Yanikoglu, Berrin

466

Totally tubular: the mystery behind function and origin of the brain ventricular system  

E-Print Network (OSTI)

Totally tubular: the mystery behind function and origin of the brain ventricular system Laura Anne School, 240 Longwood Ave, Boston, MA, USA A unique feature of the vertebrate brain is the ventricular by neu- roepithelium. While CSF is critical for both adult brain function and embryonic brain development

Lowery, Laura Anne

467

Evaluation of Brain Atrophy Estimation Algorithms using Simulated Ground-Truth Data  

E-Print Network (OSTI)

Evaluation of Brain Atrophy Estimation Algorithms using Simulated Ground-Truth Data S. Sharma of analysis tools have been developed for the estimation of brain at- rophy using MRI. Since brain atrophy gold standards, we first propose an approach for the realistic simulation of brain tissue loss

Boyer, Edmond

468

Scientists Probe Immune System's Role in Brain Function and Neurological Disease  

E-Print Network (OSTI)

Scientists Probe Immune System's Role in Brain Function and Neurological Disease Bridget M. Kuehn E in normal brain development and in the healthy adult brain. Studies also suggest that per- turbations of these roles may under- lie some neurological diseases. Contrary to dogma that the blood- brain barrier

Boulanger, Lisa

469

Flow visualization for qualitative assessment of brain shift Lyubomir Zagorcheva, Ardeshir Goshtasbya, Martin Satterb  

E-Print Network (OSTI)

Flow visualization for qualitative assessment of brain shift Lyubomir Zagorcheva, Ardeshir, and visualization of brain shift in serial MR and CT images is presented. The method consists of three steps to represent complex brain deformations. Keywords: flow visualization, nonrigid registration, brain shift

Goshtasby, Arthur Ardeshir

470

INDEPENDENT COMPONENT ANALYSIS AND BEYOND IN BRAIN IMAGING: EEG, MEG, FMRI, AND PET  

E-Print Network (OSTI)

INDEPENDENT COMPONENT ANALYSIS AND BEYOND IN BRAIN IMAGING: EEG, MEG, FMRI, AND PET Jagath C Technological University, Singapore Âľ Laboratory of Advanced Brain Signal Processing, Brain Science Institute@ntu.edu.sg, cia@bsp.brain.riken.go.jp, vdavidsanchez@earthlink.net Abstract There is an increasing interest

Vialatte, François

471

What the Social Brain Sciences Can Tell Us About the Self  

E-Print Network (OSTI)

What the Social Brain Sciences Can Tell Us About the Self Todd F. Heatherton, C. Neil Macrae, and William M. Kelley Department of Psychological and Brain Sciences, Dartmouth College ABSTRACT--Social brain. The advent of brain imaging and other cognitive neuroscience methods has provided researchers with new tools

Kelley, William M.

472

Small-sample brain mapping: sparse recovery on spatially correlated designs with randomization and clustering  

E-Print Network (OSTI)

Small-sample brain mapping: sparse recovery on spatially correlated designs with randomization Abstract Functional neuroimaging can measure the brain's response to an external stimulus. It is used to perform brain mapping: identi- fying from these observations the brain re- gions involved. This problem

Kaski, Samuel

473

THE NEURAL BASIS OF BRAIN-STIMULATION REWARD E. T. ROLLS  

E-Print Network (OSTI)

3 THE NEURAL BASIS OF BRAIN-STIMULATION REWARD E. T. ROLLS Departmentof Experimental basis of brain-stimulationreward 1.2.1 Brain-stimulationreward sites 1.2.2 Effects of lesions on self-stimulation 1.2.3 The role of physiological concomitants of brain-stimulationreward 1.2.4 Fibre degeneration

Rolls, Edmund T.

474

Difficulties of T1 brain MRI segmentation techniques M S. Atkins*a  

E-Print Network (OSTI)

: brain segmentation, T1-head MRI, IBSR data 1. INTRODUCTION We are interested in segmenting the brain in T1-weighted head scans to find the perimeter of the brain cortex, which is useful for functional MRI , is an automatic brain segmentation algorithm for MRI head scans. In the algorithm, a lower intensity threshold, t2

Orchard, Jeffery J.

475

EEGSOLVER -BRAIN ACTIVITY AND GENETIC ALGORITHMS Paulo Aguiar Andr6 David Sandra Paulo Agostinho Rosa  

E-Print Network (OSTI)

EEGSOLVER - BRAIN ACTIVITY AND GENETIC ALGORITHMS Paulo Aguiar Andr6 David Sandra Paulo Agostinho.ist.uti.pt Keywords- EEG, Inverse Problem Solving, Genetic Al- gorithm, Brain Activity, Epilepsy. ABSTRACT Genetic an electroencephalogram (EEG), findingout where the spots of activity in the brain are. Our Brain is a mysterious machine

Boetticher, Gary D.

476

POSTER PRESENTATION Open Access Foundations for an ontology of brain areas,  

E-Print Network (OSTI)

POSTER PRESENTATION Open Access Foundations for an ontology of brain areas, circuits and functions of brain areas, brain circuits and cerebral functions. This ontology challenges the complex pattern the structural foundations of human brain function. The ontology is composed from three main modules. The first

Paris-Sud XI, Université de

477

Language and the Brain Colin Phillips, University of Maryland & Kuniyoshi L. Sakai, University of Tokyo  

E-Print Network (OSTI)

1 Language and the Brain Colin Phillips, University of Maryland & Kuniyoshi L. Sakai, University in understanding what special properties of the human brain make such feats possible. Efforts to answer of the human brain are most important for language, first using findings from brain-damaged patients

Coulson, Seana

478

IR Principles for Content-based Indexing and Retrieval of Functional Brain Images  

E-Print Network (OSTI)

IR Principles for Content-based Indexing and Retrieval of Functional Brain Images Bing Bai, Paul of a "library of brain images", which implies not only a repository of brain images, but also efficient search worked with a collection of functional MRI brain images assembled in the study of several distinct cogni

479

Evaluation of Lignans from Heliopsis helianthoides var. scabra for Their Potential Antimetastatic Effects in the Brain  

Science Journals Connector (OSTI)

scabra for Their Potential Antimetastatic Effects in the Brain ... These six compounds were evaluated in vitro in terms of their ability to inhibit the various steps involved in brain tumor metastasis formation. ... Compounds 3 and 4 inhibited the migration of both melanoma and brain endothelial cells, and 3 also reduced the adhesion of melanoma cells to the brain endothelium. ...

Zsanett Hajdu; János Haskó; István A. Krizbai; Imola Wilhelm; Nikoletta Jedlinszki; Csilla Fazakas; Judit Molnár; Peter Forgo; Judit Hohmann; Dezs? Csupor

2014-12-05T23:59:59.000Z

480

Brain states and circuit mechanisms underlying sleep and general anesthesia  

E-Print Network (OSTI)

During sleep and general anesthesia, the brain enters a state of decreased arousal and consciousness is transiently suspended. How this transition occurs is a fundamental and unsolved question in neuroscience. The neural ...

Lewis, Laura D. (Laura Diane)

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "traumatic brain injury" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Proteins, anatomy and networks of the fruit fly brain   

E-Print Network (OSTI)

Our understanding of the complexity of the brain is limited by the data we can collect and analyze. Because of experimental limitations and a desire for greater detail, most investigations focus on just one aspect of the ...

Knowles-Barley, Seymour Francis

2012-06-25T23:59:59.000Z

482

STS.066 Brains and Culture: Love, Lies & Neurotransmitters, Fall 2002  

E-Print Network (OSTI)

Subject examines the brain as a cultural object in contemporary media, science, and society. Explores cultural assumptions about neuroscience by drawing on anthropology, history, semiotics, and the cognitive sciences. ...

Dumit, Joseph

483

Stuttering induced by thalamic deep brain stimulation for dystonia  

Science Journals Connector (OSTI)

We report a patient in whom deep brain stimulation of the ventral intermediate nucleus of the thalamus (Vim) for treating dystonia reversibly induced stuttering at suboptimal stimulation parameters. Adjustments o...

Niels Allert; Daniela Kelm; Christian Blahak…

2010-05-01T23:59:59.000Z

484

The Social Brain: Neural Basis of Social Knowledge  

E-Print Network (OSTI)

The Social Brain: Neural Basis of Social Knowledge Ralph Adolphs California Institute of Technology FurtherANNUAL REVIEWS #12;Contents KNOWLEDGE OF MINDS . . . . . . . . . 694 Comparative Studies . . . . . . . . . . . . . . . 694 Knowledge of the Minds of Others . . . . . . . . . . . . . . . . . . . . . . . 694 Knowledge

Dickerson, Brad

485

Interaction proteomics reveals brain region-specific AMPA receptor complexes  

Science Journals Connector (OSTI)

Fast excitatory synaptic transmission in the brain is mediated by glutamate acting on postsynaptic AMPA receptors. Recent studies have revealed a substantial number of AMPA receptor auxiliary proteins, which potentially contribute to the regulation of ...

Ning Chen; Nikhil Janak Pandya; Frank Koopmans; Violeta Castelo-Székely; Roel C. van der Schors; August B. Smit; Ka Wan Li

2014-10-22T23:59:59.000Z

486

Brain Iron as an Early Predictor of Alzheimer's Disease | Advanced...  

NLE Websites -- All DOE Office Websites (Extended Search)

| 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Brain Iron as an Early Predictor of Alzheimer's Disease JUNE 15, 2011 Bookmark and Share (A)...

487

High-Tech Brain Implant Predicts, Prevents Epileptic Seizures...  

NLE Websites -- All DOE Office Websites (Extended Search)

High-Tech Brain Implant Predicts, Prevents Epileptic Seizures (ANL-IN-08-043) Argonne National Laboratory Contact ANL About This Technology

Prototype of a seven-element cooling...

488

System Provides Clear Brain Scans of Awake, Unrestrained Mice...  

NLE Websites -- All DOE Office Websites (Extended Search)

System Provides Clear Brain Scans of Awake, Unrestrained Mice dynamic imaging of mice Three markers attached to the head of a mouse enable the AwakeSPECT system to obtain detailed,...

489

Scientists model brain structure to help computers recognize...  

NLE Websites -- All DOE Office Websites (Extended Search)

Do you see what I see? Scientists model brain structure to help computers recognize objects The team tried developing a computer model based on human neural structure and function,...

490

TRACTOGRAPHY OF FORNIX, CINGULUM, AND CORPUS CALLOSUM IN RAT BRAIN  

E-Print Network (OSTI)

was performed and visually inspected for anatomical correctness according to a rat atlas brain. Values of Trace as the effects of pharmacological drugs on white matter. DISCUSSION Figure 4: Trace, FA, RD, and AD Figure 1: Rat

491

Consciousness and the Social Brain | Princeton Plasma Physics...  

NLE Websites -- All DOE Office Websites (Extended Search)

0, 2015, 9:30am to 11:00am MBG Auditorium Consciousness and the Social Brain Professor Michael Graziano, Department of Psychology Princeton University Abstract: Graziano.pdf...

492

Generative models of brain connectivity for population studies  

E-Print Network (OSTI)

Connectivity analysis focuses on the interaction between brain regions. Such relationships inform us about patterns of neural communication and may enhance our understanding of neurological disorders. This thesis proposes ...

Venkataraman, Archana, Ph. D. Massachusetts Institute of Technology

2012-01-01T23:59:59.000Z

493

Stuttering reperfusion of ischemic myocardium does not exacerbate myocardial infarction: Evidence against lethal cell reperfusion injury in the rabbit  

Science Journals Connector (OSTI)

In the clinical setting of acute myocardial infarction, coronary reperfusion may occur intermittently. Whether this intermittent or stuttering reperfusion exacerbates reperfusion cell injury is not known. To inve...

Kevin J. Alker; Stephen D. Bellows…

1996-01-01T23:59:59.000Z

494

Cortical Activation During Spatiotemporal Processing in the Infant Brain  

E-Print Network (OSTI)

CORTICAL ACTIVATION DURING SPATIOTEMPORAL PROCESSING IN THE INFANT BRAIN A Thesis by JENNIFER RUTH ARMSTRONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE December 2008 Major Subject: Psychology CORTICAL ACTIVATION DURING SPATIOTEMPORAL PROCESSING IN THE INFANT BRAIN A Thesis by JENNIFER RUTH ARMSTRONG Submitted to the Office of Graduate Studies...

Armstrong, Jennifer R.

2010-01-14T23:59:59.000Z

495

Intentionality, Artificial Intelligence and the Causal Powers of the Brain  

E-Print Network (OSTI)

Intentionality, Artificial Intelligence and the Causal Powers of the Brain Jeffrey M. Whitmer Northern Illinois University It seems to be a common belief that in the future, if not in the present, digital computers are going to be capable... of cognitive states, experiences, and con­ sciousness equal in every respect to that which exists in human beings. 1 Not everyone, however, is so optimistic. One such skeptic is John Searle and his "Minds, Brains, and Programs" 2 represents a direct con...

Whitmer, Jeffrey M.

496

Membrane associated phospholipase C from bovine brain  

SciTech Connect

Cytosolic fractions of bovine brain contain 2 immunologically distinct phosphoinositide-specific phospholipase (PLC), PLC-I and PLC-II, whose MW are 150,000 and 145,000 respectively, under a denaturing condition. Monoclonal antibodies were derived against each form and specific radioimmunoassays were developed. Distribution of PLC-I and PLC-II in cytosolic and particulate fractions was measured using the radioimmunoassay. More than 90% of PLC-II was found in the cytosolic fraction, while the anti-PLC-I antibody cross-reacting protein was distributed nearly equally between the soluble fraction and the 2 M KCl extract of particulate fraction. The PLC enzyme in the particulate fraction was purified to homogeneity, yielding 2 proteins of 140 KDa and 150 KDa when analyzed on SDS-PAGE. Neither of the 2 enzymes cross-reacted with anti-PLC-II antibodies, but both could be immunoblotted by all 4 different anti-PLC-I antibodies. This suggests that the 140 KDa PLC was derived from the 150 KDa form. The 150 Kda form from particulate fraction was indistinguishable from the cytosolic PLC-I when their mixture was analyzed on SDS-PAGE. In addition, the elution profile of tryptic peptides derived from the 150 KDa particulate form was identical to that of cytosolic PLC-I. This result indicates that PLC-I is reversibly associated to membranes.

Lee, K.; Ryu, S.H.; Suh, P.; Choi, W.C.; Rhee, S.G.

1987-05-01T23:59:59.000Z

497

Vulnerability of the Superficial Zone of Immature Articular Cartilage to Compressive Injury  

SciTech Connect

The zonal composition and functioning of adult articular cartilage causes depth-dependent responses to compressive injury. In immature cartilage, shear and compressive moduli as well as collagen and sulfated glycosaminoglycan (sGAG) content also vary with depth. However, there is little understanding of the depth-dependent damage caused by injury. Since injury to immature knee joints most often causes articular cartilage lesions, this study was undertaken to characterize the zonal dependence of biomechanical, biochemical, and matrix-associated changes caused by compressive injury. Disks from the superficial and deeper zones of bovine calves were biomechanically characterized. Injury to the disks was achieved by applying a final strain of 50% compression at 100%/second, followed by biomechanical recharacterization. Tissue compaction upon injury as well as sGAG density, sGAG loss, and biosynthesis were measured. Collagen fiber orientation and matrix damage were assessed using histology, diffraction-enhanced x-ray imaging, and texture analysis. Injured superficial zone disks showed surface disruption, tissue compaction by 20.3 {+-} 4.3% (mean {+-} SEM), and immediate biomechanical impairment that was revealed by a mean {+-} SEM decrease in dynamic stiffness to 7.1 {+-} 3.3% of the value before injury and equilibrium moduli that were below the level of detection. Tissue areas that appeared intact on histology showed clear textural alterations. Injured deeper zone disks showed collagen crimping but remained undamaged and biomechanically intact. Superficial zone disks did not lose sGAG immediately after injury, but lost 17.8 {+-} 1.4% of sGAG after 48 hours; deeper zone disks lost only 2.8 {+-} 0.3% of sGAG content. Biomechanical impairment was associated primarily with structural damage. The soft superficial zone of immature cartilage is vulnerable to compressive injury, causing superficial matrix disruption, extensive compaction, and textural alteration, which results in immediate loss of biomechanical function. In conjunction with delayed superficial sGAG loss, these changes may predispose the articular surface to further softening and tissue damage, thus increasing the risk of development of secondary osteoarthritis.

Rolauffs, R.; Muehleman, C; Li, J; Kurz, B; Kuettner, K; Frank, E; Grodzinsky, A

2010-01-01T23:59:59.000Z

498

Cultivating Better Brains: Transhumanism and its Critics on the Ethics of Enhancement Via Brain-computer Interfacing.  

E-Print Network (OSTI)

??Transhumanists contend that enhancing the human brain—a subfield of human enhancement called cognitive enhancement—is both a crucial and desirable pursuit toward cultivating a better world.… (more)

Devlin, Matthew

2014-01-01T23:59:59.000Z

499

PPAR-{gamma} agonist protects against intestinal injury during necrotizing enterocolitis  

SciTech Connect

Necrotizing enterocolitis (NEC) remains a lethal condition for many premature infants. Peroxisome proliferator-activated receptor-{gamma} (PPAR-{gamma}), a member of the nuclear hormone receptor family, has been shown to play a protective role in cellular inflammatory responses; however, its role in NEC is not clearly defined. We sought to examine the expression of PPAR-{gamma} in the intestine using an ischemia-reperfusion (I/R) model of NEC, and to assess whether PPAR-{gamma} agonist treatment would ameliorate I/R-induced gut injury. Swiss-Webster mice were randomized to receive sham (control) or I/R injury to the gut induced by transient occlusion of superior mesenteric artery for 45 min with variable periods of reperfusion. I/R injury resulted in early induction of PPAR-{gamma} expression and activation of NF-{kappa}B in small intestine. Pretreatment with PPAR-{gamma} agonist, 15d-PGJ{sub 2}, attenuated intestinal NF-{kappa}B response and I/R-induced gut injury. Activation of PPAR-{gamma} demonstrated a protective effect on small bowel during I/R-induced gut injury.

Baregamian, Naira; Mourot, Joshua M.; Ballard, Amie R. [Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0353 (United States); Evers, B. Mark [Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0353 (United States); Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Chung, Dai H. [Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0353 (United States); Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 (United States)], E-mail: dhchung@utmb.edu

2009-02-06T23:59:59.000Z

500

Bayesian spatial and ecological models for small-area accident and injury analysis  

Science Journals Connector (OSTI)

In this article, recently developed Bayesian spatial and ecological regression models are applied to analyse small-area variation in accident and injury. This study serves to demonstrate how Bayesian modelling techniques can be implemented to assess potential risk factors measured at group (e.g. area) level. Presented here is a unified modelling framework that enables thorough investigations into associations between injury rates and regional characteristics, residual variation and spatial autocorrelation. Using hospital separation data for 83 local health areas in British Columbia (BC), Canada, in 1990–1999, we explore and examine ecological/contextual determinants of motor vehicle accident injury (MVAI) among male children and youth aged 0–24 and for those of six age groups (ecological studies shed light on reasons for regional variations in accident occurrence as well as in the resulting injuries and hospital utilisation. Thereby they are potentially useful in identifying priority areas for injury/accident prevention and in informing regional health planning and policy development.

Ying C. MacNab

2004-01-01T23:59:59.000Z