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1

USFS Humboldt-Toiyabe National Forest | Open Energy Information  

Open Energy Info (EERE)

USFS Humboldt-Toiyabe National Forest USFS Humboldt-Toiyabe National Forest Jump to: navigation, search Name USFS Humboldt-Toiyabe National Forest Short Name Humbolt-Toiyabe NF Parent Organization United States Forest Service Address 1200 Franklin Way Place Sparks, NV Zip 89431 Phone number (775) 331-6444 Website http://www.fs.usda.gov/main/ht References Humboldt-Toiyabe NF Website[1] This article is a stub. You can help OpenEI by expanding it. USFS Toiyabe National Forest is an organization based in Sparks, Nevada, Sparks, Nevada. References ↑ "Humboldt-Toiyabe NF Website" Retrieved from "http://en.openei.org/w/index.php?title=USFS_Humboldt-Toiyabe_National_Forest&oldid=640692" Categories: Government Agencies Stubs What links here Related changes Special pages Printable version

2

NVN-079666 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2541.85 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

3

NVN-079352 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1160 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

4

NVN-079665 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

5

NVN-079668 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2585.51 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

6

NVN-079664 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

7

NVN-074253 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

8

NVN-079307 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

9

NVN-079663 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2213.1 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

10

NVN-079310 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 655 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

11

NVN-074250 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1199 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

12

NVN-074254 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

13

NVN-077646 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 80 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

14

NVN-079667 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

15

NVN-077647 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

16

NVN-079276 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

17

NVN-078687 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 1180 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 REESE...

18

NVN-079291 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1295.88 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

19

NVN-077668 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 3297.94 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

20

NVN-080159 | Open Energy Information  

Open Energy Info (EERE)

(section) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

NVN-079104 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2480.99 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

22

NVN-079105 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2356.36 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

23

NVN-079305 | Open Energy Information  

Open Energy Info (EERE)

1 Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1811.109 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

24

NVN-079106 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2588.75 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

25

NVN-077739 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1271.82 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 PATUA...

26

NVN-080086 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 650.32 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

27

NVN-074249 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1860.19 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

28

NVN-078688 | Open Energy Information  

Open Energy Info (EERE)

8688 8688 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-078688 Case Data Survey Type Unsurveyed - uprotracted Case Status Authorized Case Type GEO_LEASE_NONCOMPETITI Total Acreage 2525 Bid Price/Acre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 REESE RIVER GEO POWER LLC Lessee 2 none provided Effective Date 10/1/2004 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 10/1/2004 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0230N Range 0430E Section 3 Aliquot nw,s2 Retrieved from "http://en.openei.org/w/index.php?title=NVN-078688&oldid=661594" Category: BLM Geothermal Case What links here

29

NVN-079306 | Open Energy Information  

Open Energy Info (EERE)

6 6 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-079306 Case Data Survey Type B Case Status Authorized Case Type GEO_LSE_NONCOMP_PRE_2005 Total Acreage 2140.53 Bid Price/Acre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 7/1/2006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate 10% - 5% - 5% Most Recent Action RLTY RATE -10%- Most Recent Action Date 7/1/2006 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0270N Range 0320E Section 2 Aliquot nenesw,w2w2sw Retrieved from "http://en.openei.org/w/index.php?title=NVN-079306&oldid=665211" Category: BLM Geothermal Case What links here

30

The REMOTE SENSlNf  

Office of Legacy Management (LM)

REMOTE REMOTE SENSlNf ' . 1 ARllRllRRv OF THE UNITED STATES DEPARTMENT OF ENERGY . . . . .a. * ~~&hrEAWWMms Gap ~~&hrEAwwMms Gap ECT FOLLdW-UP REPORT ECT FOLLdW-UP REPORT NOVEMBER 1979 NOVEMBER 1979 AN AERIAL RADIOLOGICAL SURVEY OF THE CURTIS BAY FACILITY OF THE W. FL GRACE COMPANY Baltimore, Maryland t. Kent Hilton Project Scientist APPROVED FORPUBLlCATlON ' : T. P. Stuart, Manager Remote Sensing Sciences Department ATTACHMENT 4- ECT Follow-Up Report AN AERIAL RADIOLOGICAL SURVEY OF THE CURTIS BAY FACILITY This is the second of two reports discussing the gamma ray radiation levels measured at the Curtis Bay facility of the W. R. Grace Company. The first report presented gross count contours and gamma ray spectra over the most active areas. Refined gross count isopleth maps will be

31

CACA-014407 | Open Energy Information  

Open Energy Info (EERE)

Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1 ORNI 51 LLC Lessee 2 none provided Effective Date 211985 Expire Date Held By Production (HBP)...

32

Molecular Cell XIAP Induces NF-kB Activation  

E-Print Network (OSTI)

Molecular Cell Article XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 NF-kB and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here with TAB1 to induce NF-kB activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1

Wu, Hao

33

NF kappa B expression and matrix metalloproteinase activity in hypertension  

E-Print Network (OSTI)

299-306, 1995. Baldwin A.S. The NF-kB and IkB Proteins: Newof transcription factor NF-kB in mouse glomerular mesangialwere then labeled with anti-NF-kB p65 rabbit polyclonal

Wu, Kwan-I

2009-01-01T23:59:59.000Z

34

Cloning and expression of equine NF-kB2  

E-Print Network (OSTI)

Equine infectious anemia virus (EIAV) is a macrophage-tropic retrovirus that causes persistent disease in horses and ponies. In addition to its structural proteins, EIAV encodes four regulatory/accessory genes, tat, rev, ttm, and S2. It has been documented EIAV S2 gene expression is essential for disease expression of EIAV. Using a yeast two-hybrid assay, it was shown that S2 protein interacts with human NF-KB2. NF-KB2 plays a key role in the alternative or non-canonical NF-KB pathway. In order to determine if the interaction of S2 with NF-KB2 might be relevant to equine disease, a cDNA representing full length equine NF-KB2 was generated in our laboratory using PCR and rapid amplification of cDNA ends. To our knowledge this is the first time that equine NF-KB2 cDNAs have been recovered and characterized. The sequence of equine NF-KB2 was 95% homologous to human overall, however a major difference was found in the ankyrin repeat region where protein-protein interactions occur. Two splice variants of equine NF-KB2 were found that correspond to splice variants of human NF- KB2. We tested the interaction of EIAV S2 and equine NF-KB2 using the yeast two hybrid system (Y2H) and co-immunoprecipitation. Unfortunately we were not able to detect an interaction between EIAV S2 and equine NF-KB2 in either system. Despite this result, NF-KB2 is an important component in the immune response so we examined its expression in equine macrophages. Moreover we were interested to know if EIAV might affect expression levels of equine NF-KB2, as NF-KB2 is a target of other viruses. Hence, the expression level of equine NF-KB2 was measured in uninfected and infected primary equine monocyte- derived macrophage (eMDM). Using quantitative PCR we determined that equine NF-KB2 gene expression is decreased in eMDM after 3 days post plating, about the time that monocytes start to differentiate into mature macrophages. However EIAV infection of eMDM upregulated the expression level of NF-KB2.

Mirhosseini, Negin

2008-05-01T23:59:59.000Z

35

CMRR-NF SEIS Scoping Information | National Nuclear Security...  

National Nuclear Security Administration (NNSA)

OctoberNovember 2010 Scoping meeting posters Welcome How You Can Submit Your Comments LANL Technical Areas Chemistry and Metallurgy Research Replacement (CMRR) CMRR-NF SEIS...

36

A NF-kappaB temporal code to ensure specificity in inflammatory signaling  

E-Print Network (OSTI)

requires the interaction of NF-kB with other transcriptionD. 2006. Circuitry of NF-kB Signaling. Immunological Reviewscontrol the dynamics of NF-kB signaling and gene expression.

Werner, Shannon L.

2009-01-01T23:59:59.000Z

37

Quantitative characterization and analysis of the dynamic NF-kappaB response in microglia  

E-Print Network (OSTI)

J, Wirth T, Schwaninger M: NF- kB is activated and promotesdomains of A20 downregulate NF-kB signalling. Nature 2004,Levchenko A: Understanding NF-kB signaling via mathematical

Sheppard, Patrick W; Sun, Xiaoyun; Emery, John F; Giffard, Rona G; Khammash, Mustafa

2011-01-01T23:59:59.000Z

38

Temporal encoding and homeostatic control in the IKK- kappaNF-kappaB signaling system  

E-Print Network (OSTI)

to control constitutive NF-kB activity." Molecular SystemsPharmacological Inhibitors on NF-kB Activation TimecoursesPharmacological Inhibitors on NF-kB Activation 102   x

Barken, Derren

2007-01-01T23:59:59.000Z

39

Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness  

E-Print Network (OSTI)

A. , and Ghosh, G. 2007. NF-kB dictates IkB degradationI?B protein within the NF-kB signaling module. ” Cell. 128:

O'Dea, Ellen Louise

2010-01-01T23:59:59.000Z

40

CACA-014408 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 693.6 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1...

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

CACA-011667 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 1590 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1...

42

Modulation of the NF-kB Pathway by Bordetella  

E-Print Network (OSTI)

Background: Filamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells. Given the importance of the NF-kB transcription factor family in these host cell responses, we examined the effect of FHA on NF-kB activation in macrophages and bronchial epithelial cells, both of which are relevant cell types during natural infection. Methodology/Principal Findings: Exposure to FHA of primary human monocytes and transformed U-937 macrophages, but not BEAS-2B epithelial cells, resulted in early activation of the NF-kB pathway, as manifested by the degradation of cytosolic IkBa, by NF-kB DNA binding, and by the subsequent secretion of NF-kB-regulated inflammatory cytokines. However, exposure of macrophages and human monocytes to FHA for two hours or more resulted in the accumulation of cytosolic IkBa, and the failure of TNF-a to activate NF-kB. Proteasome activity was attenuated following exposure of cells to FHA for 2 hours, as was the nuclear translocation of RelA in BEAS-2B cells. Conclusions: These results reveal a complex temporal dynamic, and suggest that despite short term effects to the contrary, longer exposures of host cells to this secreted adhesin may block NF-kB activation, and perhaps lead to a compromised immune response to this bacterial pathogen.

Pertussis Filamentous Hemagglutinin; Tzvia Abramson; Hassya Kedem; David A. Relman

2008-01-01T23:59:59.000Z

43

Kinetics of NF-kB nucleocytoplasmic transport probed by single-cell screening without imaging  

E-Print Network (OSTI)

Kinetics of NF-kB nucleocytoplasmic transport probed by single-cell screening without imaging Jun of nucleocytoplasmic transport of an important transcription factor NF-kB. With data collected from single cells, we activation barrier for NF-kB transport. Our data demonstrate that NF-kB nucleocytoplasmic transport fits

Lu, Chang

44

Charting the NF-kB Pathway Interactome Map  

E-Print Network (OSTI)

Inflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor kB (NF-kB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hundreds of genes. Several signaling pathways activated by diverse stimuli converge on NF-kB activation, resulting in a regulatory system characterized by high complexity. It is increasingly recognized that the number of components that impinges upon phenotypic outcomes of signal transduction pathways may be higher than those taken into consideration from canonical pathway representations. Scope of the present analysis is to provide a wider, systemic picture of the NF-kB signaling system. Data from different sources such as literature, functional enrichment web resources, protein-protein interaction and pathway databases have been gathered, curated, integrated and analyzed in order to reconstruct a single, comprehensive picture of the proteins that interact with, and participate to the NF-kB activation system. Such a reconstruction shows that the NF-kB interactome is substantially different in quantity and quality of components with respect to canonical representations. The analysis highlights that several neglected but topologically central proteins may play a role in the activation of NF-kB mediated responses. Moreover the interactome structure fits with the characteristics of a bow tie architecture. This interactome is intended as an open network resource available for further development,

Paolo Tieri; Alberto Termanini; Elena Bellavista; Stefano Salvioli; Miriam Capri

2011-01-01T23:59:59.000Z

45

NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function  

SciTech Connect

NF45/ILF2 associates with NF90/ILF3 in the nucleus and regulates IL-2 gene transcription at the antigen receptor response element (ARRE)/NF-AT DNA target sequence (P.N. Kao, L. Chen, G. Brock, J. Ng, A.J. Smith, B. Corthesy, J. Biol. Chem. 269 (1994) 20691-20699). NF45 is widely expressed in normal tissues, especially testis, brain, and kidney, with a predominantly nuclear distribution. NF45 mRNA expression is increased in lymphoma and leukemia cell lines. The human and murine NF45 proteins differ only by substitution of valine by isoleucine at amino acid 142. Fluorescence in situ hybridization localized the human NF45 gene to chromosome 1q21.3, and mouse NF45 gene to chromosome 3F1. Promoter analysis of 2.5 kB of the murine NF45 gene reveals that significant activation is conferred by factors, possible including NF-Y, that bind to the CCAAT-box sequence. The function of human NF45 in regulating IL-2 gene expression was characterized in Jurkat T-cells stably transfected with plasmids directing expression of NF45 cDNA in sense or antisense orientations. NF45 sense expression increased IL-2 luciferase reporter gene activity 120-fold, and IL-2 protein expression 2-fold compared to control cells. NF45 is a highly conserved, regulated transcriptional activator, and one target gene is IL-2.

Zhao Guohua [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Shi Lingfang [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Qiu Daoming [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Hu Hong [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Kao, Peter N. [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States)]. E-mail: peterkao@stanford.edu

2005-05-01T23:59:59.000Z

46

Transcriptional regulation of antimicrobial peptide induction by NF-[kappa]B family members during the Drosophila melanogaster immune response  

E-Print Network (OSTI)

Dl), a member of the NF-kB family, through degradation ofworks in conjunction with NF-kB members to regulate fat bodystandard deviation. (C). Role of fly NF-kB proteins in AttA

Busse, Matthew Schmidt

2007-01-01T23:59:59.000Z

47

Mathematical model of NF-kB regulatory module  

E-Print Network (OSTI)

The two-feedback-loop regulatory module of nuclear factor kB (NF-kB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkB (IKK) and NF-kB; the inhibitors A20 and IkBa; and their complexes. In resting cells, the unphosphorylated IkBa binds to NF-kB and sequesters it in an inactive form in the cytoplasm. In response to extracellular signals such as tumor necrosis factor or interleukin-1, IKK is transformed from its neutral form (IKKn) into its active form (IKKa), a form capable of phosphorylating IkBa; leading to IkBa degradation. Degradation of IkBa releases the main activator NF-kB; which then enters the nucleus and triggers transcription of the inhibitors and numerous other genes. The newly synthesized IkBa leads NF-kB out of the nucleus and sequesters it in the cytoplasm, while A20 inhibits IKK converting IKKa into the inactive form (IKKi), a form different from IKKn, no longer capable of phosphorylating IkBa: After parameter fitting, the proposed model is able to properly reproduce time behavior of all variables for which the data are available: NF-kB; cytoplasmic IkBa; A20 and IkBa mRNA transcripts, IKK and IKK catalytic activity in both wild-type and A20-deficient cells. The model allows detailed analysis of kinetics of the involved proteins and their complexes and gives the predictions of the possible responses of whole kinetics to the change in the level of a given activator or inhibitor.

Tomasz Lipniacki A; Pawel Paszek B; Allan R. Brasier D; Bruce Luxon C; Marek Kimmel B

2003-01-01T23:59:59.000Z

48

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1  

E-Print Network (OSTI)

super family pathway and NF-kB pathway, such as TRADD, RELB,genes from wound healing and NF-kB signaling. Samples in the

Verhaak, Roel GW

2010-01-01T23:59:59.000Z

49

Physiological functions for brain NF-kB Mollie K. Meffert and David Baltimore  

E-Print Network (OSTI)

Physiological functions for brain NF-kB Mollie K. Meffert and David Baltimore Division of BiologyB (NF-kB) family of transcription factors are activated within the CNS in pathological settings of the mechanisms of Ca2C -responsive activation and synaptic signaling to the nucleus by NF-kB transcription

Baltimore, David

50

Single-cell NF-kB dynamics reveal digital activation and analogue information processing  

E-Print Network (OSTI)

LETTERS Single-cell NF-kB dynamics reveal digital activation and analogue information processing information to the gene expression programs by means of the transcription factor nuclear factor (NF)-kB. We measured NF-kB activity in thousands of live cells under TNF-a doses covering four orders of magnitude. We

Quake, Stephen R.

51

ORIGINAL ARTICLE NF-jB activation by combinations of NEMO SUMOylation and ATM  

E-Print Network (OSTI)

The Rel/NF-kB family of transcription factors has been intensively studied as an important paradigm expression profiles (reviewed in Hayden and Ghosh (2004)). The proto- typical mammalian NF-kB complex, a p50 necrosis factor (TNF), interleukin-1 and bacterial lipopolysaccharide (LPS), activate NF-kB via convergence

Miyamoto, Shigeki

52

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module  

E-Print Network (OSTI)

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module Diane M of the transcription factor NF-kB. Linear stability analysis of the model shows that oscillatory frequency is a hard system minimizes stochastic excursions of the output to produce a robust NF-kB response. Citation: Longo

Hasty, Jeff

53

NF-[kappa]B RelB/p52 heterodimer : biogenesis and DNA recognition  

E-Print Network (OSTI)

A fourth IkB protein in the NF-kB signaling module. Cell, InCD28 is mediated through an NF-kB-like response element. JTo further test how other NF-kB dimers interact with CREB,

Fusco, Amanda J.

2007-01-01T23:59:59.000Z

54

Vol. 2003, Issue 36, pp. nf17, 10 September 2003 [DOI: 10.1126/sageke.2003.36.nf17  

E-Print Network (OSTI)

Document URL: http://sageke.sciencemag.org/cgi/content/full/sageke;2003/36/nf17 Science , . This article sophomore year in 1987. "It was actually a science experiment gone awry," confesses Gazzaley with a giggle into the toilet bowl. But he had miscalculated the power of the reaction: The resulting explosion shook

55

b-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-jB  

E-Print Network (OSTI)

: b-arrestin2; CK2; NF-kB Introduction The UV response in mammalian cells is mediated through activation of several transcription factors, including NF-kB (Shaulian et al, 2000). In resting cells, NF-kB by Silverman and Maniatis, 2001). The binding of IkB to NF-kB masks the nuclear localization sequences (NLS

Tian, Weidong

56

COMMD1 promotes the ubiquitination of NF-jB subunits through a cullin-containing ubiquitin  

E-Print Network (OSTI)

& transcription; proteins Keywords: COMMD1; cullin; NF-kB; transcription; ubiquitination Introduction NF-kB im- munity, apoptosis, and cell cycle progression (Karin and Lin, 2002). In mammals, NF-kB subunits into the mature p50 and p52 subunits, respectively. NF-kB is ordinarily sequestered in the cytoplasm

Burstein, Ezra

57

NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1a  

E-Print Network (OSTI)

LETTERS NF-kB links innate immunity to the hypoxic response through transcriptional regulation, regulated by several transcription factors, among which NF-kB plays a central role5,6 . NF-kB activation between NF-kB and HIF-1a has proven elusive. Using in vitro systems, it was reported that HIF-1a activates

Nizet, Victor

58

Low Dose Radiation Research Program: Regulation of NF-kB and MnSOD in Low  

NLE Websites -- All DOE Office Websites (Extended Search)

NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li School of Health Sciences, Purdue University West Lafayette, Indiana Why this Project? To determine if low dose ionizing radiation-induced adaptive responses in skin cells are mediated by activation of signaling networks. Project Goals To evaluate the signaling networks involving transcription factor NF-kB and the mitochondrial antioxidant protein MnSOD. To determine if NF-kB is activated by low dose radiation in vivo. To determine if NF-kB activation is critical in the pathways that produce adaptive responses. Experimental Approach Cells transfected with NF-kB luciferase responder genes will be used to define a dose-response relationship for activation of the NF-kB gene. NF-kB

59

The IkBa/NF-kB complex has two hot spots, one at either end of the interface  

E-Print Network (OSTI)

The IkBa/NF-kB complex has two hot spots, one at either end of the interface SIMON BERGQVIST,1 of NF-kB family members via its ankyrin repeat (AR) domain. The binding affinity of IkBa with NF-kB(p50/p65) heterodimers and NF-kB(p65/65) homodimers is in the picomolar range, and in the cell

Komives, Elizabeth A.

60

Myelin Activates FAK/Akt/NF-kB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine  

E-Print Network (OSTI)

Myelin Activates FAK/Akt/NF-kB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine is through activation of FAK/PI3K/Akt/NF-kB signaling pathways and CR3 contributes to myelin-induced PI3K/Akt/NF-kB) are not able to activate NF-kB signaling pathway. In conclusion, our results demonstrate a crucial role

Fan, Jianqing

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links  

E-Print Network (OSTI)

An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell to cancer, and NF-kB appears to play a causa- tive role, but the mechanisms are poorly understood. We show activation triggers an inflammatory response mediated by NF-kB that directly activates Lin28 transcription

62

NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B  

E-Print Network (OSTI)

E. A. (2008) The IkBa/NF-kB complex has two hot-spots, oneThe genes regulated by NF-kB fall into various functionaldimerization domains and NF-kB p65 amino-terminal domain (

Cervantes, Carla F.

2010-01-01T23:59:59.000Z

63

Dying for NF-jB? Control of cell death by transcriptional regulation of the apoptotic machinery  

E-Print Network (OSTI)

Ezra Burstein and Colin S DuckettÃ? The transcription factor nuclear factor kB (NF-kB) is a pleiotropic signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-kB showed that loss or suppression of NF-kB results in an enhanced sensitivity to apoptosis. In the ensuing

Burstein, Ezra

64

WntD is a feedback inhibitor of Dorsal/NF-kB in Drosophila development and immunity  

E-Print Network (OSTI)

WntD is a feedback inhibitor of Dorsal/NF-kB in Drosophila development and immunity Michael D. Gordon1 , Marc S. Dionne2 , David S. Schneider2 & Roel Nusse1 Regulating the nuclear factor-kB (NF-kB melanogaster have proved fruitful in determining the signals used to control NF-kB proteins, beginning

Bejerano, Gill

65

NF-{kappa}B regulates Lef1 gene expression in chondrocytes  

SciTech Connect

The relation of Wnt/{beta}-catenin signaling to osteoarthritis progression has been revealed with little information on the underlying molecular mechanism. In this study we found overexpression of Lef1 in cartilage tissue of osteoarthritic patients and elucidated molecular mechanism of NF-{kappa}B-mediated Lef1 gene regulation in chondrocytes. Treatment of IL-1{beta} augmented Lef1 upregulation and nuclear translocation of NF-{kappa}B in chondrocytes. Under IL-1{beta} signaling, treatment of NF-{kappa}B nuclear translocation inhibitor SN-50 reduced Lef1 expression. A conserved NF-{kappa}B-binding site between mouse and human was selected through bioinformatic analysis and mapped at the 14 kb upstream of Lef1 transcription initiation site. NF-{kappa}B binding to the site was confirmed by chromatin immunoprecipitation assay. Lef1 expression was synergistically upregulated by interactions of NF-{kappa}B with Lef1/{beta}-catenin in chondrocytes. Our results suggest a pivotal role of NF-{kappa}B in Lef1 expression in arthritic chondrocytes or cartilage degeneration.

Yun, Kangsun [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of); Choi, Yoo Duk [Department of Pathology, Chonnam National University Medical School, Gwangju 501-749 (Korea, Republic of); Nam, Jong Hee [Department of Pathology, Chonnam National University Medical School, Gwangju 501-749 (Korea, Republic of); Park, Zeeyoung [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of); Im, Sin-Hyeog [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of)]. E-mail: imsh@gist.ac.kr

2007-06-08T23:59:59.000Z

66

La activacin de NF-kB, indicador de recada en el cncer de mama  

E-Print Network (OSTI)

La activación de NF-kB, indicador de recaída en el cáncer de mama La ausencia de la proteína 14 proteico relacio- nado con la progresión tumoral, NF-kB, según apunta un estudio en PLoS ONE realiza- do activación de NF-kB en los tumores como el mejor indi- cador de recaída en las pa- cientes de cáncer de mama

Foissac, Sylvain

67

AZA-009168 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2005 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

68

AZA-009186 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2471.1 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL...

69

AZA-009170 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

70

AZA-009175 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2190 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

71

AZA-009191 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL...

72

AZA-009169 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

73

AZA-009190 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2018.7 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL...

74

UTU-029557 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 2594.37 Bid PriceAcre Managing Field Office none provided Surface Manager FISHLAKE NF Lessee 1 ENEL...

75

CACA-011672 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 800 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1 ORNI 10 LLC...

76

Polycystin-1 promotes PKC{alpha}-mediated NF-{kappa}B activation in kidney cells  

Science Conference Proceedings (OSTI)

Polycystin-1 (PC1), the PKD1 gene product, is a membrane receptor which regulates many cell functions, including cell proliferation and apoptosis, both typically increased in cyst lining cells in autosomal dominant polycystic kidney disease. Here we show that PC1 upregulates the NF-{kappa}B signalling pathway in kidney cells to prevent cell death. Human embryonic kidney cell lines (HEK293{sup CTT}), stably expressing a PC1 cytoplasmic terminal tail (CTT), presented increased NF-{kappa}B nuclear levels and NF-{kappa}B-mediated luciferase promoter activity. This, consistently, was reduced in HEK293 cells in which the endogenous PC1 was depleted by RNA interference. CTT-dependent NF-{kappa}B promoter activation was mediated by PKC{alpha} because it was blocked by its specific inhibitor Ro-320432. Furthermore, it was observed that apoptosis, which was increased in PC1-depleted cells, was reduced in HEK293{sup CTT} cells and in porcine kidney LtTA cells expressing a doxycycline-regulated CTT. Staurosporine, a PKC inhibitor, and parthenolide, a NF-{kappa}B inhibitor, significantly reduced the CTT-dependent antiapoptotic effect. These data reveal, therefore, a novel pathway by which polycystin-1 activates a PKC{alpha}-mediated NF-{kappa}B signalling and cell survival.

Banzi, Manuela [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Aguiari, Gianluca [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Trimi, Viky [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Mangolini, Alessandra [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Pinton, Paolo [General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara (Italy); Witzgall, Ralph [Institute for Molecular and Cellular Anatomy, University of Regensburg, Regensburg (Germany); Rizzuto, Rosario [General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara (Italy); Senno, Laura del [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy)]. E-mail: sen@unife.it

2006-11-17T23:59:59.000Z

77

MicroRNAs Modulate the Dynamics of the NF-kB Signaling Pathway  

E-Print Network (OSTI)

Background: NF-kB, a major transcription factor involved in mammalian inflammatory signaling, is primarily involved in regulation of response to inflammatory cytokines and pathogens. Its levels are tightly regulated since uncontrolled inflammatory response can cause serious diseases. Mathematical models have been useful in revealing the underlying mechanisms, the dynamics, and other aspects of regulation in NF-kB signaling. The recognition that miRNAs are important regulators of gene expression, and that a number of miRNAs target different components of the NF-kB network, motivate the incorporation of miRNA regulated steps in existing mathematical models to help understand the quantitative aspects of miRNA mediated regulation. Methodology/Principal findings: In this study, two separate scenarios of miRNA regulation within an existing model are considered. In the first, miRNAs target adaptor proteins involved in the synthesis of IKK that serves as the NF-kB activator. In the second, miRNAs target different isoforms of IkB that act as NF-kB inhibitors. Simulations are carried out under two different conditions: when all three isoforms of IkB are present (wild type), and when only one isoform (IkBa) is present (knockout type). In both scenarios, oscillations in the NF-kB levels are observed and are found to be dependent on the levels of miRNAs. Conclusions/Significance: Computational modeling can provide fresh insights into intricate regulatory processes. The

Ida Vaz; Arvind Singh Mer; Alok Bhattacharya; Ramakrishna Ramaswamy

2011-01-01T23:59:59.000Z

78

Optineurin Is Required for CYLD-Dependent Inhibition of TNFa-Induced NF-kB Activation  

E-Print Network (OSTI)

The nuclear factor kappa B (NF-kB) regulates genes that function in diverse cellular processes like inflammation, immunity and cell survival. The activation of NF-kB is tightly controlled and the deubiquitinase CYLD has emerged as a key negative regulator of NF-kB signalling. Optineurin, mutated in certain glaucomas and amyotrophic lateral sclerosis, is also a negative regulator of NF-kB activation. It competes with NEMO (NF-kB essential modulator) for binding to ubiquitinated RIP (receptor interacting protein) to prevent NF-kB activation. Recently we identified CYLD as optineurin-interacting protein. Here we have analysed the functional significance of interaction of optineurin with CYLD. Our results show that a glaucomaassociated mutant of optineurin, H486R, is altered in its interaction with CYLD. Unlike wild-type optineurin, the H486R mutant did not inhibit tumour necrosis factor a (TNFa)-induced NF-kB activation. CYLD mediated inhibition of TNFainduced NF-kB activation was abrogated by expression of the H486R mutant. Upon knockdown of optineurin, CYLD was unable to inhibit TNFa-induced NF-kB activation and showed drastically reduced interaction with ubiquitinated RIP. The level of ubiquitinated RIP was increased in optineurin knockdown cells. Deubiquitination of RIP by over-expressed CYLD was abrogated in optineurin knockdown cells. These results suggest that optineurin regulates NF-kB activation by mediating

Ananthamurthy Nagabhushana; Megha Bansal; Ghanshyam Swarup

2010-01-01T23:59:59.000Z

79

Imaging Pulmonary NF-kappaB Activation and Therapeutic Effects of MLN120B and TDZD-8  

E-Print Network (OSTI)

NF-kB activation is a critical signaling event in the inflammatory response and has been implicated in a number of pathological lung diseases. To enable the assessment of NF-kB activity in the lungs, we transfected a luciferase based NF-kB reporter into the lungs of mice or into Raw264.7 cells in culture. The transfected mice showed specific luciferase expression in the pulmonary tissues. Using these mouse models, we studied the kinetics of NF-kB activation following exposure to lipopolysaccharide (LPS). The Raw264.7 cells expressed a dose-dependent increase in luciferase following exposure to LPS and the NF-kB reporter mice expressed luciferase in the lungs following LPS challenge, establishing that bioluminescence imaging provides adequate sensitivity for tracking the NF-kB activation pathway. Interventions affecting the NF-kB pathway are promising clinical therapeutics, thus we further examined the effect of IKK-2 inhibition by MLN120B and glycogen synthase kinase 3 beta inhibition by TDZD-8 on NF-kB activation. Pre-treatment with either MLN120B or TDZD-8 attenuated NF-kB activation in the pulmonary tissues, which was accompanied with suppression of pro-inflammatory chemokine MIP-1ß and induction of anti-inflammatory cytokine IL-10. In summary, we have established an imaging based approach for noninvasive and longitudinal assessment of NF-kB activation and regulation during acute lung injury. This approach will

Dan Ansaldi; Eldad A. Hod; Fabio Stellari; Jae-beom Kim; Mark Roskey; Kevin P. Francis; Rajendra Singh; Ning Zhang

2011-01-01T23:59:59.000Z

80

A test of first order scaling in Nf=2 QCD  

E-Print Network (OSTI)

We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

2007-09-30T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

The role of the phosphorus BIBII transition in proteinDNA recognition: the NF-kB complex  

E-Print Network (OSTI)

The role of the phosphorus BI±BII transition in protein±DNA recognition: the NF-kB complex K) containing the HIV-1 NF-kB-binding site, in which the sequences ¯anking the kB site had been mutated. 31P NMR of the BI±BII equilibrium in NF-kB recognition by DNA was then investigated by electrophoretic mobility

Paris-Sud XI, Université de

82

Theoretical analyses predict A20 regulates period of NF-kB oscillation  

E-Print Network (OSTI)

The nuclear-cytoplasmic shuttling of NF-kB is characterized by damped oscillations of the nuclear concentration with a time period of around 1-2 hours. The NF-kB network contains several feedback loops modulating the overall response of NF-kB activity. While IkBa is known to drive and IkBe is known to dampen the oscillations, the precise role of A20 negative feedback remains to be elucidated. Here we propose a model of the NF-kB system focusing on three negative feedback loops (IkBa, IkBe and A20) which capture the experimentally observed responses in wild-type and knockout cells. We find that A20, like IkBe, efficiently dampens the oscillations albeit through a distinct mechanism. In addition, however, we have discovered a new functional role of A20 by which it controls the oscillation period of nuclear NF-kB. The design based on three nested feedback loops allows independent control of period and amplitude decay in the oscillatory response. Based on these results we predict that adjusting the expression lev...

Mengel, Benedicte; Jensen, Mogens H; Trusina, Ala

2009-01-01T23:59:59.000Z

83

Evolutionary Conserved Regulation of HIF-1b by NF-kB  

E-Print Network (OSTI)

Hypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions. HIF-a subunit quantities and their associated activity are regulated in a post-translational manner, through the concerted action of a class of enzymes called Prolyl Hydroxylases (PHDs) and Factor Inhibiting HIF (FIH) respectively. However, alternative modes of HIF-a regulation such as translation or transcription are under-investigated, and their importance has not been firmly established. Here, we demonstrate that NF-kB regulates the HIF pathway in a significant and evolutionary conserved manner. We demonstrate that NF-kB directly regulates HIF-1b mRNA and protein. In addition, we found that NF-kB–mediated changes in HIF-1b result in modulation of HIF-2a protein. HIF-1b overexpression can rescue HIF-2a protein levels following NF-kB depletion. Significantly, NF-kB regulates HIF-1b (tango) and HIF-a (sima) levels and activity (Hph/fatiga, ImpL3/ldha) in Drosophila, both in normoxia and hypoxia, indicating an evolutionary conserved mode of regulation. These results reveal a novel mechanism of HIF regulation, with impact in the development of

Patrick Van Uden; Niall S. Kenneth; Ryan Webster; H. Arno Müller; Sharon Mudie; Sonia Rocha

2010-01-01T23:59:59.000Z

84

Endocytosis-Independent Function of Clathrin Heavy Chain in the Control of Basal NF-kB Activation  

E-Print Network (OSTI)

Background: Nuclear factor-kB (NF-kB) is a transcription factor that regulates the transcription of genes involved in a variety of biological processes, including innate and adaptive immunity, stress responses and cell proliferation. Constitutive or excessive NF-kB activity has been associated with inflammatory disorders and higher risk of cancer. In contrast to the mechanisms controlling inducible activation, the regulation of basal NF-kB activation is not well understood. Here we test whether clathrin heavy chain (CHC) contributes to the regulation of basal NF-kB activity in epithelial cells. Methodology: Using RNA interference to reduce endogenous CHC expression, we found that CHC is required to prevent constitutive activation of NF-kB and gene expression. Immunofluorescence staining showed constitutive nuclear localization of the NF-kB subunit p65 in absence of stimulation after CHC knockdown. Elevated basal p65 nuclear localization is caused by constitutive phosphorylation and degradation of inhibitor of NF-kB alpha (IkBa) through an IkB kinase a (IKKa)-dependent mechanism. The role of CHC in NF-kB signaling is functionally relevant as constitutive expression of the proinflammatory chemokine interleukin-8 (IL-8), whose expression is regulated by NF-kB, was found after CHC knockdown. Disruption of clathrin-mediated endocytosis by chemical inhibition or depletion of the m2-subunit of the endocytosis adaptor protein AP-2, and knockdown of clathrin light chain a (CHLa), failed to induce constitutive NF-kB activation and IL-8 expression, showing that CHC acts on NF-kB independently of endocytosis and CLCa.

Man Lyang Kim; Isabel Sorg; Cécile Arrieumerlou

2011-01-01T23:59:59.000Z

85

Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB  

E-Print Network (OSTI)

The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has ...

Nguyen, Hung Nhat

2011-01-01T23:59:59.000Z

86

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

Science Conference Proceedings (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

87

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-kB by Human T-Lymphotropic Virus  

E-Print Network (OSTI)

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-kB by Human T Nuclear factor (NF)-kB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-kB occurs predominantly in the cytoplasm, where Tax1 binds NF-kB

Paris-Sud XI, Université de

88

Poxvirus Targeting of E3 Ligase b-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-kB Activation and  

E-Print Network (OSTI)

Poxvirus Targeting of E3 Ligase b-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-kB, Trinity College Dublin, Dublin, Ireland Abstract The transcription factor NF-kB is essential for immune degradation of IkBa. Here we describe an inhibitor of NF-kB from vaccinia virus that has a closely related

Utrecht, Universiteit

89

NF-kB activation by ultraviolet light not dependent on a nuclear signal  

Science Conference Proceedings (OSTI)

Exposure of mammalian cells to radiation triggers the ultraviolet (UV) response, which includes activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kB). This was postulated to occur by induction of a nuclear signaling cascade by damaged DNA. Recently, induction of AP-1 by UV was shown to be mediated by a pathway involving Src tyrosine kinases and the Ha-Ras small guanosine triphosphate-binding protein, proteins located at the plasma membrane. It is demonstrated here that the same pathway mediates induction of NF-kB by UV. Because inactive NF-kB is stored in the cytosol, analysis of its activation directly tests the involvement of a nuclear-initiated signaling cascade. Enucleated cells are fully responsive to UV both in NF-kB induction and in activation of another key signaling event. Therefore, the UV response does not require a signal generated in the nucleus and is likely to be initiated at or near the plasma membrane.

Devary, Y.; Rosette, C.; DiDonato, J.A.; Karin, M. (Univ. of California, San Diego, CA (United States))

1993-09-10T23:59:59.000Z

90

Original article Induction of apoptosis and NF-B by quercetin  

E-Print Network (OSTI)

activity of NF-B, which may implicate an increasing resistance to their cytotoxicity. quercetin / TNF) Abstract -- Polyphenol quercetin induced apoptosis in proliferating murine L1210 lymphocytic cells. DNA promoting activity of quercetin was enhanced by physiological concentrations of TNF-. At the same time

Recanati, Catherine

91

IS NF-B A GOOD TARGET FOR CANCER THERAPY? HOPES AND PITFALLS  

E-Print Network (OSTI)

clear that aberrant regulation of NF-B and the signaling pathways that control its activity are involved and acquire drug resistance4, 5 . The current armamentarium of medical oncology includes many active, such as innate and adaptive immune responses, cell proliferation, cell death, and inflammation. It has become

Paris-Sud XI, Université de

92

Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization  

Science Conference Proceedings (OSTI)

The NF-kB family of transcription factors regulates important biological functions including cell growth, survival and the immune response. We found that Human Papillomavirus type 16 (HPV-16) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone, the anatomic region where most cervical cancers develop. In contrast, HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner. NF-kB influenced immortalization of cervical cells by HPV16. Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16. In contrast, activation of NF-kB by constitutive expression of p65 inhibited proliferation and immortalization. Our results suggest that inhibition of NF-kB by HPV-16 E6/E7 contributes to immortalization of cells from the cervical transformation zone.

Vandermark, Erik R.; Deluca, Krysta A.; Gardner, Courtney R.; Marker, Daniel F.; Schreiner, Cynthia N.; Strickland, David A.; Wilton, Katelynn M. [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States)] [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States); Mondal, Sumona [Department of Mathematics, Clarkson University, Potsdam, NY 13699-5805 (United States)] [Department of Mathematics, Clarkson University, Potsdam, NY 13699-5805 (United States); Woodworth, Craig D., E-mail: woodworth@clarkson.edu [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States)

2012-03-30T23:59:59.000Z

93

Purinergic Signaling is Required for Fluid Shear Stress-Induced NF-kB Translocation in Osteoblasts  

SciTech Connect

Fluid shear stress regulates gene expression in osteoblasts, in part by activation of the transcription factor NF-kB. We examined whether this process was under control of purinoceptor activation. MC3T3-E1 osteoblasts under static conditions expressed the NF-kB inhibitory protein IkB alpha and exhibited cytosolic localization of NF-kB. Under fluid shear stress, I?B? levels decreased, and concomitant nuclear localization of NF-kB was observed. Cells exposed to fluid shear stress in ATP-depleted medium exhibited no significant reduction in I?B?, and NF-kB remained within the cytosol. Similar results were found using oxidized ATP or Brilliant Blue G, P2X7 receptor antagonists, indicating that the P2X7 receptor is responsible for fluid shear-stress-induced I?B? degradation and nuclear accumulation of NF-kB. Pharmacologic blockage of the P2Y6 receptor also prevented shear-induced IkB alpha degradation. These phenomena involved neither ERK1/2 signaling nor autocrine activation by P2X7-generated lysophosphatidic acid. Our results suggest that fluid shear stress regulates NF-kB activity through the P2Y6 and P2X7 receptor.

Genetos, Damian C.; Karin, Norman J.; Geist, Derik J.; Donahue, Henry J.; Duncan, Randall L.

2011-04-01T23:59:59.000Z

94

Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface  

Science Conference Proceedings (OSTI)

To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H. [China Medical University, Shenyang (China)

2009-07-01T23:59:59.000Z

95

Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business  

SciTech Connect

This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

2011-02-01T23:59:59.000Z

96

IKKa and IKKb Each Function to Regulate NF-kB Activation in the TNF-Induced/Canonical Pathway  

E-Print Network (OSTI)

Background: Activation of the transcription factor NF-kB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkB proteins. The IKK complex is comprised of two catalytic subunits, IKKa and IKKb, and a regulatory protein known as NEMO. Using cells from mice that are genetically deficient in IKKb or IKKa, or using a kinase inactive mutant of IKKb, it has been proposed that IKKb is critical for TNF-induced IkB phosphorylation/degradation through the canonical pathway while IKKa has been shown to be involved in the noncanonical pathway for NF-kB activation. These conclusions have led to a focus on development of IKKb inhibitors for potential use in inflammatory disorders and cancer. Methodology: Analysis of NF-kB activation in response to TNF in MEFs reveals that IKKb is essential for efficient phosphorylation and subsequent degradation of IkBa, yet IKKa contributes to the NF-kB activation response in these cells as measured via DNA binding assays. In HeLa cells, both IKKa and IKKb contribute to IkBa phosphorylation and NF-kB activation. A kinase inactive mutant of IKKb, which has been used as evidence for the critical importance of IKKb in TNFinduced signaling, blocks activation of NF-kB induced by IKKa, even in cells that are deficient in IKKb. Conclusions: These results demonstrate the importance of IKKa in canonical NF-kB activation, downstream of cytokine

Mazhar Adli; Evan Merkhofer; Patricia Cogswell; Albert S. Baldwin

2009-01-01T23:59:59.000Z

97

TRIM30a negatively regulates TLR-mediated NF-jB activation by targeting TAB2 and TAB3 for degradation  

E-Print Network (OSTI)

of the transcription factor NF-kB and stress-activated protein kinases5 and then induces the expression of genes encoding immune and proinflammatory molecules6. Activation of NF-kB by a TLR signal depends on the activity of the inhibitor of NF-kB (IkB) kinase (IKK) complex. In turn, activation of both IKK and TAK1 (A002249

Tian, Weidong

98

XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization  

Science Conference Proceedings (OSTI)

In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-{kappa}B and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-{kappa}B activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-{kappa}B pathway. We report the crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex. The BIR1/TAB1 structure reveals a striking butterfly-shaped dimer and the detailed interaction between BIR1 and TAB1. Structure-based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-{kappa}B activation. We show that although not interacting with BIR1, Smac, the antagonist for caspase inhibition by XIAP, also inhibits the XIAP/TAB1 interaction. Disruption of BIR1 dimerization abolishes XIAP-mediated NF-{kappa}B activation, implicating a proximity-induced mechanism for TAK1 activation.

Lu,M.; Lin, S.; Huang, Y.; Kang, Y.; Rich, R.; Lo, Y.; Myszka, D.; Han, J.; Wu, H.

2007-01-01T23:59:59.000Z

99

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-kB Activity by Targeting TNFa Receptor-Associated Factors  

E-Print Network (OSTI)

Enteropathogenic Escherichia coli (EPEC) disease depends on the transfer of effector proteins into epithelia lining the human small intestine. EPEC E2348/69 has at least 20 effector genes of which six are located with the effector-delivery system genes on the Locus of Enterocyte Effacement (LEE) Pathogenicity Island. Our previous work implied that non-LEE-encoded (Nle) effectors possess functions that inhibit epithelial anti-microbial and inflammation-inducing responses by blocking NF-kB transcription factor activity. Indeed, screens by us and others have identified novel inhibitory mechanisms for NleC and NleH, with key co-operative functions for NleB1 and NleE1. Here, we demonstrate that the LEE-encoded Translocatedintimin receptor (Tir) effector has a potent and specific ability to inhibit NF-kB activation. Indeed, biochemical, imaging and immunoprecipitation studies reveal a novel inhibitory mechanism whereby Tir interaction with cytoplasm-located TNFa receptor-associated factor (TRAF) adaptor proteins induces their proteasomal-independent degradation. Infection studies support this Tir-TRAF relationship but reveal that Tir, like NleC and NleH, has a non-essential contribution in EPEC’s NF-kB inhibitory capacity linked to Tir’s activity being suppressed by undefined EPEC factors. Infections in a disease-relevant intestinal model confirm key NF-kB inhibitory roles for the NleB1/NleE1 effectors, with other studies providing insights on host targets. The work not only reveals a second Intimin-independent property for Tir and a novel EPEC effector-mediated NF-kB inhibitory mechanism but also lends itself to speculations on the evolution of EPEC’s capacity to inhibit NF-kB

Marie-hélène Ruchaud-sparagano; Sabrina Mühlen; Paul Dean; Brendan Kenny

2011-01-01T23:59:59.000Z

100

Introducing Spatial Information into Predictive NF-kB Modelling – An Agent-Based Approach  

E-Print Network (OSTI)

Nature is governed by local interactions among lower-level sub-units, whether at the cell, organ, organism, or colony level. Adaptive system behaviour emerges via these interactions, which integrate the activity of the sub-units. To understand the system level it is necessary to understand the underlying local interactions. Successful models of local interactions at different levels of biological organisation, including epithelial tissue and ant colonies, have demonstrated the benefits of such ‘agent-based ’ modelling [1–4]. Here we present an agent-based approach to modelling a crucial biological system – the intracellular NF-kB signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species [5–7]. Alterations in pathway regulation underlie a variety of diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches [8]. The method also permits consideration of structural parameters in pathway regulation; here we predict that inhibition of NF-kB is directly affected by actin filaments of the cytoskeleton sequestering excess inhibitors, therefore regulating steady-state and feedback

Mark Pogson; Mike Holcombe; Rod Smallwood; Eva Qwarnstrom

2008-01-01T23:59:59.000Z

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101

The Surface Activation Layer of GaAs Negative Electron Affinity Photocathode Activated by Cs, Li and NF3  

Science Conference Proceedings (OSTI)

The lifetime of GaAs photocathodes can be greatly improved by introducing Li in the Cs+NF{sub 3} activation process. The surface activation layer of such photocathodes is studied by synchrotron radiation photoemission and is compared with GaAs photocathodes activated without Li. The charge distributions of N, F and Cs experience significant changes when Li is added in the activation. In addition, the presence of Li causes NF{sub x} molecules to take an orientation with F atoms on top. All these changes induced by Li hold the key for the lifetime improvement of GaAs photocathodes.

Sun, Yun; /SLAC, SSRL; Kirby, R.E.; /Saxet Surface Sci.; Maruyama, T.; /SLAC; Mulhollan, G.A.; Bierman, J.C.; /Saxet Surface Sci.; Pianetta, P.; /SLAC, SSRL

2009-12-11T23:59:59.000Z

102

The TCL1A Oncoprotein Interacts Directly with the NF-kB Inhibitor IkB  

E-Print Network (OSTI)

The T cell leukaemia/lymphoma 1A (TCL1A) oncoprotein plays key roles in several B and T cell malignancies. Lacking enzymatic activity, TCL1A’s transforming action was linked to its capacity to co-activate the protein kinase AKT via binding to its pleckstrin homology (PH) domain. However, perturbation of AKT signalling alone was recently shown insufficient to explain TCL1A oncogenesis, suggesting that TCL1A has additional cellular partners. Searching for such additional targets, we found that TCL1A binds specifically and directly to the ankyrin domain of IkB, the inhibitor of the NF-kB transcription factors. Through binding assays and a structural analysis by small angle X-ray scattering, we show that TCL1A and IkB interact in yeast-two-hybrid systems, when transiently overexpressed in 293 cells, and as recombinant proteins in vitro. We further establish that the association between TCL1A and IkB is compatible with AKT binding to TCL1A, but incompatible with IkB binding to NF-kB. By interfering with the inhibition of NF-kB byIkB, TCL1A may increase the concentration of free NF-kB molecules sufficiently to trigger expression of anti-apoptotic genes. Thus our data suggest an additional route by

Virginie Ropars; Gilles Despouy; Marc-henri Stern; Serge Benichou; Stefan T. Arold

2009-01-01T23:59:59.000Z

103

Nat Rev Drug Discov. Author manuscript Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls  

E-Print Network (OSTI)

and the signaling pathways that control its activity are involved in cancer development and progression, as well resistance , .4 5 The current armamentarium of medical oncology includes many active anticancer agents, cell proliferation, cell death, and inflammation. It has become clear that aberrant regulation of NF- B

Paris-Sud XI, Université de

104

Towards thermodynamics with $N_f=2+1+1$ twisted mass quarks  

E-Print Network (OSTI)

We present preliminary results achieved within a recently started project dealing with QCD thermodynamics in the presence of a fully dynamical second quark family. We are employing the Wilson twisted mass discretization. To reduce the amount of zero temperature simulations and the cost of analysis we have chosen the fixed-scale approach. We show a variety of basic thermodynamic observables for temperatures ranging from 158 to 633 MeV. Simulations were performed for three lattice spacings below 0.1 fm each and at a single value of the pion mass which allows a comparison with previously obtained $N_f=2$ results. We determine the chiral crossover temperature from the bare chiral susceptibility and show results for the gauge part of the trace anomaly.

Florian Burger; Grit Hotzel; Michael Müller-Preussker; Ernst-Michael Ilgenfritz; Maria Paola Lombardo

2013-11-07T23:59:59.000Z

105

Determining the conformal window: SU(2) gauge theory with N_f = 4, 6 and 10 fermion flavours  

E-Print Network (OSTI)

We study the evolution of the coupling in SU(2) gauge field theory with $N_f=4$, 6 and 10 fundamental fermion flavours on the lattice. These values are chosen close to the expected edges of the conformal window, where the theory possesses an infrared fixed point. We use improved Wilson-clover action, and measure the coupling in the Schr\\"odinger functional scheme. At four flavours we observe that the couping grows towards the infrared, implying QCD-like behaviour, whereas at ten flavours the results are compatible with a Banks-Zaks type infrared fixed point. The six flavour case remains inconclusive: the evolution of the coupling is seen to become slower at the infrared, but the accuracy of the results falls short from fully resolving the fate of the coupling. We also measure the mass anomalous dimension for the $N_f=6$ case.

Tuomas Karavirta; Jarno Rantaharju; Kari Rummukainen; Kimmo Tuominen

2011-11-17T23:59:59.000Z

106

KT McDonald IDS-NF Plenary Meeting (RAL) Apr 6, 20132 1 Engineering Issues for the  

E-Print Network (OSTI)

Diagnostics Controls and Interlocks Health and Safety Mechanical Decommissioning Remote Handling and Hot Cells 10,730,099 1.06.07 - Remote Handling Systems 14,348,362 1.06.08 - Controls 3,076,899 1.06.09 - Beam. #12;KT McDonald IDS-NF Plenary Meeting (RAL) Apr 6, 20132 19 We must have an activated-air handling

McDonald, Kirk

107

GEF-H1 Mediated Control of NOD1 Dependent NF-kB Activation by Shigella Effectors  

E-Print Network (OSTI)

Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange factor H1 (GEF-H1) mediates RhoA activation required for cell invasion by the enteroinvasive pathogen Shigella flexneri. Surprisingly, GEF-H1 is requisite for NF-kB activation in response to Shigella infection. GEF-H1 interacts with NOD1 and is required for RIP2 dependent NF-kB activation by H-Ala-DcGlu-DAP (cTriDAP). GEF-H1 is essential for NF-kB activation by the Shigella effectors IpgB2 and OspB, which were found to signal in a NOD1 and RhoA Kinase (ROCK) dependent manner. Our results demonstrate that GEF-H1 is a critical component of cellular defenses forming an intracellular sensing system with NOD1 for the detection of microbial effectors during cell

Atsuko Fukazawa; Carmen Alonso; Kiyotaka Kurachi; Sonal Gupta; Cammie F. Lesser; Beth Ann; Hans-christian Reinecker

2008-01-01T23:59:59.000Z

108

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module  

E-Print Network (OSTI)

Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What remains unclear is whether oscillatory behavior is the basis for a signaling code based on frequency modulation (FM) or whether the negative feedback control modules have evolved to fulfill other functional requirements. Here, we use experimentally calibrated computational models to interrogate the negative feedback loops that regulate the dynamic activity of the transcription factor NF-kB. Linear stability analysis of the model shows that oscillatory frequency is a hard-wired feature of the primary negative feedback loop and not a function of the stimulus, thus arguing against an FM signaling code. Instead, our modeling studies suggest that the two feedback loops may be tuned to provide for rapid activation and inactivation capabilities for transient input signals of a wide range of durations; by minimizing late phase oscillations response durations may be fine-tuned in a graded rather than quantized manner. Further, in the presence of molecular noise the dual delayed negative feedback system minimizes stochastic

Diane M. Longo; Jangir Selimkhanov; Jeffrey D. Kearns; Jeff Hasty; Er Hoffmann; Lev S. Tsimring

2013-01-01T23:59:59.000Z

109

NF-kB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti- Sense Protein HBZ  

E-Print Network (OSTI)

Activation of I-kB kinases (IKKs) and NF-kB by the human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation. Paradoxically, expression of Tax in most cells leads to drastic up-regulation of cyclin-dependent kinase inhibitors, p21 CIP1/WAF1 and p27 KIP1, which cause p53-/pRb-independent cellular senescence. Here we demonstrate that p21 CIP1/WAF1-/p27 KIP1-mediated senescence constitutes a checkpoint against IKK/NF-kB hyper-activation. Senescence induced by Tax in HeLa cells is attenuated by mutations in Tax that reduce IKK/NFkB activation and prevented by blocking NF-kB using a degradation-resistant mutant of I-kBa despite constitutive IKK activation. Small hairpin RNA-mediated knockdown indicates that RelA induces this senescence program by acting upstream of the anaphase promoting complex and RelB to stabilize p27 KIP1 protein and p21 CIP1/WAF1 mRNA respectively. Finally, we show that down-regulation of NF-kB by the HTLV-1 anti-sense protein, HBZ, delay or prevent the onset of Taxinduced senescence. We propose that the balance between Tax and HBZ expression determines the outcome of HTLV-1 infection. Robust HTLV-1 replication and elevated Tax expression drive IKK/NF-kB hyper-activation and trigger senescence. HBZ, however, modulates Tax-mediated viral replication and NF-kB activation, thus allowing HTLV-1-infected cells to proliferate, persist, and evolve. Finally, inactivation of the senescence checkpoint can facilitate persistent NF-kB activation

Huijun Zhi; Liangpeng Yang; Yu-liang Kuo; Yik-khuan Ho; Hsiu-ming Shih; Chou-zen Giam

2011-01-01T23:59:59.000Z

110

Non-Canonical NF-kB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2  

E-Print Network (OSTI)

Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3) activity. Ectopic expression of the fusion protein activates the canonical NF-kB signaling cascade, but how it does so is controversial and how it promotes MALT lymphoma is unknown. Considering recent reports implicating c-IAP1 and c-IAP2 E3 activity in repression of non-canonical NF-kB signaling, we asked if the c-IAP2/MALT fusion protein can initiate non-canonical NF-kB activation. Here we show that in addition to canonical activation, the fusion protein stabilizes NIK and activates noncanonical NF-kB. Canonical but not non-canonical activation depended on MALT1 paracaspase activity, and expression of E3-inactive c-IAP2 activated non-canonical NF-kB. Mice in which endogenous c-IAP2 was replaced with an E3-inactive mutant accumulated abnormal B cells with elevated non-canonical NF-kB and had increased numbers of B cells with a marginal zone phenotype, gut-associated lymphoid hyperplasia, and other features of MALT lymphoma. Thus, the c-IAP2/ MALT1 fusion protein activates NF-kB by two distinct mechanisms, and loss of c-IAP2 E3 activity in vivo is sufficient to induce abnormalities common to MALT lymphoma.

Dietrich B. Conze; Yongge Zhao; Jonathan D. Ashwell

2010-01-01T23:59:59.000Z

111

Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells  

Science Conference Proceedings (OSTI)

The increased adhesion of monocytes to injured endothelial layers is a critical early event in atherogenesis. Under inflammatory conditions, there is increased expression of specific cell adhesion molecules on activated vascular endothelial cells, which increases monocyte adhesion. In our current study, we demonstrate a putative mechanism for the anti-inflammatory effects of carnosol, a diterpene derived from the herb rosemary. Our results show that both carnosol and rosemary essential oils inhibit the adhesion of TNFalpha-induced monocytes to endothelial cells and suppress the expression of ICAM-1 at the transcriptional level. Moreover, carnosol was found to exert its inhibitory effects by blocking the degradation of the inhibitory protein IkappaBalpha in short term pretreatments but not in 12 h pretreatments. Our data show that carnosol reduces IKK-beta phosphorylation in pretreatments of less than 3 h. In TNFalpha-treated ECs, NF-kappaB nuclear translocation and transcriptional activity was abolished by up to 12 h of carnosol pretreatment and this was blocked by Nrf-2 siRNA. The long-term inhibitory effects of carnosol thus appear to be mediated through its induction of Nrf-2-related genes. The inhibition of ICAM-1 expression and p65 translocation is reversed by HO-1 siRNA. Carnosol also upregulates the Nrf-2-related glutathione synthase gene and thereby increases the GSH levels after 9 h of exposure. Treating ECs with a GSH synthesis inhibitor, BSO, blocks the inhibitory effects of carnosol. In addition, carnosol increases p65 glutathionylation. Hence, our present findings indicate that carnosol suppresses TNFalpha-induced singling pathways through the inhibition of IKK-beta activity or the upregulation of HO-1 expression. The resulting GSH levels are dependent, however, on the length of the carnosol pretreatment period.

Lian, K.-C.; Chuang, J.-J.; Hsieh, C.-W. [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Wung, B.-S., E-mail: bswung@mail.ncyu.edu.t [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Huang, G.-D.; Jian, T.-Y. [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Sun, Y.-W. [Department of Biotechnology, Seed Improvement and Propagation Station, Taichung, Taiwan (China)

2010-05-15T23:59:59.000Z

112

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling  

SciTech Connect

SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-{kappa}B). The ankyrin repeats of G9a-like protein (GLP) recognizes RelA monomethylated at Lys310. Adjacent to Lys310 is Ser311, a known phosphorylation site of RelA. Ser311 phosphorylation inhibits Lys310 methylation by SETD6 as well as binding of Lys310me1 by GLP. The structure of SETD6 in complex with RelA peptide containing the methylation site, in the presence of S-adenosyl-l-methionine, reveals a V-like protein structure and suggests a model for NF-{kappa}B binding to SETD6. In addition, structural modeling of the GLP ankyrin repeats bound to Lys310me1 peptide provides insight into the molecular basis for inhibition of Lys310me1 binding by Ser311 phosphorylation. Together, these findings provide a structural explanation for a key cellular signaling pathway centered on RelA Lys310 methylation, which is generated by SETD6 and recognized by GLP, and incorporate a methylation-phosphorylation switch of adjacent lysine and serine residues. Finally, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. Given the restriction of Rubisco to plant species, this particular appearance of the protein lysine methyltransferase has been evolutionarily well conserved.

Chang, Yanqi; Levy, Dan; Horton, John R.; Peng, Junmin; Zhang, Xing; Gozani, Or; Cheng, Xiaodong (Emory-MED); (Stanford)

2011-10-10T23:59:59.000Z

113

Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics  

E-Print Network (OSTI)

Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is a ligand-dependent nuclear receptor. It is a long-standing observation that inflammatory responses and infections decrease drug metabolism capacity in human and experimental animals. In this study, I reported that NF-?B activation by LPS and TNF-? plays a pivotal role in the suppression of CYP3A4 through interactions of NF-?B with PXR/RXR complex. Inhibition of NF-?B by NF-?B specific suppressor SRI?B? reversed the suppressive effects of LPS and TNF-?. Furthermore, I showed that NF-?B p65 disrupted the association of PXR/RXR? complex with DNA sequences as determined by EMSA and chromatin immunoprecipitation assays. NF-?B p65 directly interacted with DNA binding domain of RXR? and DNA binding domain, hinge domain and ligand-binding domain of PXR and may prevent its binding to the consensus DNA sequences, thus inhibiting the transactivation by PXR/RXR? complex. This mechanism of suppression by NF-?B activation may be extended to other nuclear receptor-regulated systems where RXR? is a dimerization partner. Many genes regulated by PXR and AhR are important for phase I, II and III drug metabolism. In this study I reported a crosstalk between PXR and AhR pathways. AhR physically and functionally interacted with PXR and enhanced the PXR transcriptional activity, and the interaction repressed the AhR transcriptional activity. AhR also physically interacted with RXR?. The synergistic induction of Gsta1 in the liver of mice by PCN and TCDD might assume a different mechanism. The results suggested the metabolism kinetics of mixture drugs was different from and more complicated than that of single compound. Using a HepG2 cell-based PXR-driven CYP3A4-Luciferase assay, I reported that E/F domain of PXR was responsible for ligand-dependant activation. A/B domain was necessary for co-activating the ligand-dependent activation and D domain was suppressive. High doses of Valerian Root extraction were PXR-dependent CYP3A4 inducers. Green tea polyphenols, aflatoxin B1, CuSO4 and MnCl2 enhanced the PXR transcription activity activated by rifampicin. The results suggested PXR-mediated drug metabolism kinetics altered on xenobiotic exposure.

Gu, Xinsheng

2007-08-01T23:59:59.000Z

114

Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-{kappa}B  

Science Conference Proceedings (OSTI)

Phenobarbital (PB) is a nongenotoxic tumor promoter in the liver. One mechanism by which PB may exert its tumor promoting activity is by inducing oxidative stress. We previously found that PB administration increased hepatic NF-{kappa}B DNA binding activity. In this study we examined the hypothesis that the effects of PB on cell proliferation and apoptosis are dependent on NF-{kappa}B. We used a mouse model that is deficient in the p50 subunit of NF-{kappa}B; previous studies had found that p50-/- mice were less sensitive to the induction of hepatic cell proliferation by PCBs or peroxisome proliferators. Mice (p50-/- and wild-type B6129) were fed a control diet or one containing 0.05% PB for 3, 10 or 34 days. At the end of the experiment, the mice were euthanized and livers removed and processed. PB increased cell proliferation at 3 and 10 days (but not at 34 days), but the deletion of the NF-{kappa}B p50 subunit did not inhibit these increases. p50-/- Mice had higher cell proliferation at the 3 day (only in mice fed PB) and 34-day timepoints. PB decreased hepatocyte apoptosis after 3 days, slightly decreased it after 10 days, and did not affect it after 34 days. The deletion of the NF-{kappa}B p50 subunit did not influence PB's effect on apoptosis. In p50-/- mice, apoptosis was increased after 3 or 10 days compared to wild-type mice, but no effect was seen after 34 days. The hepatic expression of the NF-{kappa}B-regulated gene TNF-{alpha} correlated more with the hepatic cell proliferation data than with hepatic apoptosis, and was not decreased by the deletion of the p50 subunit. These findings show that the p50 subunit of NF-{kappa}B is not required for the alteration of hepatocyte proliferation or apoptosis by PB up to 34 days after its administration.

Tharappel, Job C. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Spear, Brett T. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States); Glauert, Howard P. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States)], E-mail: hglauert@uky.edu

2008-02-01T23:59:59.000Z

115

Artemisolide is a typical inhibitor of I{kappa}B kinase {beta} targeting cysteine-179 residue and down-regulates NF-{kappa}B-dependent TNF-{alpha} expression in LPS-activated macrophages  

SciTech Connect

Nuclear factor (NF)-{kappa}B regulates a central common signaling for immunity and cell survival. Artemisolide (ATM) was previously isolated as a NF-{kappa}B inhibitor from a plant of Artemisia asiatica. However, molecular basis of ATM on NF-{kappa}B activation remains to be defined. Here, we demonstrate that ATM is a typical inhibitor of I{kappa}B kinase {beta} (IKK{beta}), resulting in inhibition of lipopolysaccharide (LPS)-induced NF-{kappa}B activation in RAW 264.7 macrophages. ATM inhibited the kinase activity of highly purified IKK{beta} and also LPS-induced IKK activity in the cells. Moreover, the effect of ATM on IKK{beta} activity was completely abolished by substitution of Cys-179 residue of IKK{beta} to Ala residue, indicating direct targeting site of ATM. ATM could inhibit I{kappa}B{alpha} phosphorylation in LPS-activated RAW 264.7 cells and subsequently prevent NF-{kappa}B activation. Further, we demonstrate that ATM down-regulates NF-{kappa}B-dependent TNF-{alpha} expression. Taken together, this study provides a pharmacological potential of ATM in NF-{kappa}B-dependent inflammatory disorders.

Kim, Byung Hak; Lee, Jun-Young; Seo, Jee Hee; Lee, Hwa Young [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Ryu, Shi Yong [Korea Research Institute of Chemical Technology, Taejon 305-600 (Korea, Republic of); Ahn, Byung Woo [College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Lee, Chong-Kil; Hwang, Bang Yeon; Han, Sang-Bae [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Kim, Youngsoo [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of)], E-mail: youngsoo@chungbuk.ac.kr

2007-09-28T23:59:59.000Z

116

$K$ and $D$ oscillations in the Standard Model and its extensions from $N_f=2+1+1$ Twisted Mass LQCD  

E-Print Network (OSTI)

We present the first $N_f=2+1+1$ results for the matrix elements of the operators describing neutral $K$ and $D$ mixing in the Standard Model and its extensions. The combination of maximally twisted sea quarks and Osterwalder-Seiler valence quarks ensures $\\mathcal{O}(a)$-improvement and continuum like renormalization pattern. We have used the $N_f=2+1+1$ dynamical quark gauge configurations generated by ETMC. Simulations include three lattice spacings in the interval $[0.06:0.09]$ fm and pseudoscalar meson masses in the range $[230:500]$ MeV. Our results are extrapolated to the continuum limit and to the physical quark masses. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme.

Carrasco, Nuria; Frezzotti, Roberto; Giménez, Vicent; Lubicz, Vittorio; Rossi, Giancarlo; Sanfilippo, Francesco; Tarantino, Cecilia

2013-01-01T23:59:59.000Z

117

The human NFKB3 gene encoding the p65 subunit of transcription factor NF-[sub K]B is located on chromosome 11q12  

SciTech Connect

A YAC clone that contains the human gene NFKB3, encoding the p65 subunit of transcription factor nuclear factor [sub K]B (NF-[sub K]B), was isolated. The YAC contains the entire NFKB3 gene, which is smaller than 15 kb and present in a single copy in the genome. Fluorescence in situ hybridization with metaphase chromosomes showed two different chromosomal locations (11q12 and Xp11.4) for sequences present in the YAC. The NFKB3 gene was assigned to chromosome 11q12 by PCR analysis of a panel of relevant hybrid cell lines. Thus, no linkage exists between NFKB3 and genes encoding other known members of the NF-[sub K]B family. 20 refs., 2 figs.

Deloukas, P.; Loon, A.P.G.M. van (F. Hoffmann-La Roche Ltd., Basel (Switzerland)); Dauwerse, J.G.; Ommen, G.J.B. van (Univ. of Leiden (Netherlands))

1994-02-01T23:59:59.000Z

118

Fucoidan prevents C{epsilon} germline transcription and NF{kappa}B p52 translocation for IgE production in B cells  

SciTech Connect

Fucoidan, a dietary fiber contained in seaweed, reduces the increase of antigen-specific IgE in mice exposed to ovalbumin. In this study, we investigated the effect of fucoidan on IgE production and intracellular events in B cells in vitro. Fucoidan inhibited the production of IgE and C{epsilon} germline transcription in murine B cells induced by IL-4 (100 ng/ml) and anti-CD40 antibodies (10 {mu}g/ml), whereas it stimulated cell proliferation. A significant effect of fucoidan on IgE production was observed when B cells were stimulated with a higher dose (5 {mu}g/ml) of anti-CD40 antibodies, but not when stimulated with lower doses (1.25, 2.5 {mu}g/ml), regardless of the IL-4 concentrations. Moreover, nuclear translocation of NF{kappa}B p52, but neither that of NF{kappa}B p65, nor the phosphorylation of JAK1 and STAT6 was reduced by fucoidan. These results suggest that fucoidan inhibited IgE production by preventing the NF{kappa}B p52-mediated pathways activated by CD40.

Oomizu, Souichi [Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi-Hiroshima (Japan); Yanase, Yuhki [Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi-Hiroshima (Japan); Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Suzuki, Hidenori [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Kameyoshi, Yoshikazu [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Hide, Michihiro [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan)]. E-mail: mhide@hiroshima-u.ac.jp

2006-11-24T23:59:59.000Z

119

Research Article Curcumin Decreased Oxidative Stress, Inhibited NF-?B Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats  

E-Print Network (OSTI)

To study the mechanism of curcumin-attenuated inflammation and liver pathology in early stage of alcoholic liver disease, female Sprague-Dawley rats were divided into four groups and treated with ethanol or curcumin via an intragastric tube for 4 weeks. A control group treated with distilled water, and an ethanol group was treated with ethanol (7.5 g/kg bw). Treatment groups were fed with ethanol supplemented with curcumin (400 or 1 200 mg/kg bw). The liver histopathology in ethanol group revealed mild-tomoderate steatosis and mild necroinflammation. Hepatic MDA, hepatocyte apoptosis, and NF-?B activation increased significantly in ethanol-treated group when compared with control. Curcumin treatments resulted in improving of liver pathology, decreasing the elevation of hepatic MDA, and inhibition of NF-?B activation. The 400 mg/kg bw of curcumin treatment revealed only a trend of decreased hepatocyte apoptosis. However, the results of SOD activity, PPAR? protein expression showed no difference among the groups. In conclusion, curcumin improved liver histopathology in early stage of ethanol-induced liver injury by reduction of oxidative stress and inhibition of NF-?B activation. Copyright © 2009 Suchittra Samuhasaneeto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1.

Suchittra Samuhasaneeto; Duangporn Thong-ngam; Onanong Kulaputana; Doungsamon Suyasunanont; Naruemon Klaikeaw

2009-01-01T23:59:59.000Z

120

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT G.L. Greene and N.F. Ramsey  

NLE Websites -- All DOE Office Websites (Extended Search)

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT * G.L. Greene and N.F. Ramsey Harvard U n i v e r s i t y , Cambridge, N a s s a c h u s e t t s 02138 h W. Plampe i - I n s t i t u t Laue-Langevin, 38042 Grenoble, France' 9/ \ P J . M . P e n d l e b u r y and K. Smith " ' , \30ddb * A , 4 U n i v e r s i t y o f S u s s e x , Falmer, B r i g h t o n , B N I 9 Q H , U n i t e d Kingdom W . B . Dress and P.D. Miller -3 Oak Ridge N a t i o n a l L a b o r a t o r y , Oak Ridge, Tennessee 37838 P a u l P e r r i n C e n t r e d ' E t u d e s N u c l e a i r e s , 38042 C r e n o b l e , F r a n c e The n e u t r o n m a g n e t i c moment h a s been measured w i t h an improvement of a f a c t o r of 100 o v e r t h e p r e v i o u s b e s t measurement. s p e c t r o m e t e r o f t h e s e p a r a t e d o s c i l l a t o r y f i e l d t y p e c a p a b l e o f d e t e r m i n i n g a r e s o n a n c e s i g n a l f o r b o t h n e u t r o n s and p r o t o n s ( i n f l o w i n g H20), we f i n d u n / p p = 0.68497935(17)

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121

nf]r Z  

E-Print Network (OSTI)

Dear Dr. Eggenberger: This letter provides a status ofthe Office of Environmental Management (EM) actions to complete Commitment 4.4 ofthe Department ofEnergy's (DOE) Implementation Plan for Recommendation 2002-3, Requirements for the Design, Implementation, and Maintenance ofAdministrative Controls. The commitment calls for the submission ofa report on training completed and copies ofchanges to relevant training plans regarding DOE-STD-II86-2004, Specific Administrative Controls. On November 4, 2004, the Secretary revised the due date to May 31, 2005, to allow additional time after the issuance ofthe standard in August 2004. We expect all EM actions under this commitment to be met within 90 days. EM sites and activities have completed the required initial training, except for one site. The contractor at the Richland Operations Office has initiated training and will complete the training in early June 2005. A summary ofthe training conducted at EM sites is enclosed. In addition, a compact disc containing the detailed training modules has been provided to your staff. EM sites are using a variety ofmeans to institutionalize DOE STD-1186-2004 into the various training programs as shown in the enclosure. These activities are in progress and are to be completed within 90 days. Ifyou have any further questions, please call me at (202) 586-7709 or

Jij-j L. L' i U H; I L. -' " ' i; The Honorable; A. J. Eggenberger

2005-01-01T23:59:59.000Z

122

Astroglial Inhibition of NF-kB Does Not Ameliorate Disease Onset and Progression in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)  

E-Print Network (OSTI)

Motor neuron death in amyotrophic lateral sclerosis (ALS) is considered a ‘‘non-cell autonomous’ ’ process, with astrocytes playing a critical role in disease progression. Glial cells are activated early in transgenic mice expressing mutant SOD1, suggesting that neuroinflammation has a relevant role in the cascade of events that trigger the death of motor neurons. An inflammatory cascade including COX2 expression, secretion of cytokines and release of NO from astrocytes may descend from activation of a NF-kB-mediated pathway observed in astrocytes from ALS patients and in experimental models. We have attempted rescue of transgenic mutant SOD1 mice through the inhibition of the NF-kB pathway selectively in astrocytes. Here we show that despite efficient inhibition of this major pathway, double transgenic mice expressing the mutant SOD1 G93A ubiquitously and the dominant negative form of IkBa (IkBaAA) in astrocytes under control of the GFAP promoter show no benefit in terms of onset and progression of disease. Our data indicate that motor neuron death in ALS cannot be prevented by inhibition of a single inflammatory pathway because alternative pathways are activated in the

Claudia Crosio; Cristiana Valle; Arianna Casciati; Ciro Iaccarino; Maria Teresa Carrì

2011-01-01T23:59:59.000Z

123

4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK  

Science Conference Proceedings (OSTI)

Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

2005-10-01T23:59:59.000Z

124

ATF3 Plays a Key Role in Kdo 2-Lipid A-Induced TLR4- Dependent Gene Expression via NF-kB Activation  

E-Print Network (OSTI)

Background: Activating transcription factor 3 (ATF3) is a negative regulator of proinflammatory cytokine expression in macrophages, and ATF3 deficient mice are more susceptible to endotoxic shock. This study addresses the role of ATF3 in the Kdo 2-Lipid A-induced Toll-like receptor 4 (TLR4) signaling pathway in mouse embryonic fibroblasts (MEF). Kdo 2-Lipid A upregulates ATF3 expression in wild type MEF cells and induces both nuclear factor kappa B (NF-kB) and c-Jun N-terminal kinase (JNK) activation via the TLR4 signaling pathway, while neither of these pathways is activated in ATF3-/- MEF cells. Interestingly, in contrast to Kdo 2-Lipid A, the activation of both NF-kB and JNK by TNF-a was normal in ATF3-/- MEF cells. Methodology/Principal Findings: We found that several genes were dramatically upregulated in ATF3+/+ MEF cells in response to Kdo2-Lipid A treatment, while little difference was observed in the ATF3-/- MEF cells. However, we also found that the signal intensities of IkBf in ATF3-/- MEF cells were substantially higher than those in wild type MEF cells upon microarray analyses, and upregulated IkBf expression was detected in the cytosol fraction. Conclusions/Significance: Our findings indicate that ATF3 deficiency affects Kdo 2-Lipid A-induced TLR4 signaling pathways in MEF cells, that it may upregulate IkBf expression and that the high levels of IkBf expression in ATF3-/- cells disrupts Kdo2-Lipid A-mediated signaling pathways.

Eun-young Kim; Hye Young Shin; Joo-young Kim; Dong-gun Kim; Yong-min Choi; Dong-kwon Rhee; You-sun Kim; Sangdun Choi

2010-01-01T23:59:59.000Z

125

The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-{kappa}B and I{kappa}B-{gamma}: Implications for NF-{kappa}B-mediated signal transduction  

SciTech Connect

The NFKB1 gene encodes three proteins of the NF-{kappa}/Rel and I{kappa}B families: p105, p50, and (in mouse) I{kappa}B-{gamma}. We determined the complete genomic structure of human NFKB1. NFKB1 spans 156 kb and has 24 exons with introns varying between 40,000 and 323 bp in length. Although NFKB2, which encodes p100 and p52, also has 24 exons and has a comparable exon-intron structure, it is 20 times shorter than NFKB1. We propose that the long size of NFKB1 is important for transient activation of NF-{kappa}B complexes containing p50. I{kappa}B-{gamma} corresponds to the carboxyl-terminal half of p105. DNA sequence analysis showed that the 3{prime}-end of human intron 11 and the 5{prime}-end of exon 12 of NFKB1 are colinear with the 5{prime}-untranslated region of mouse I{kappa}B-{gamma} cDNA. I{kappa}B-{gamma} is thus likely to be generated by transcription starting within intron 11 and not by alternative splicing of the mouse mRNA encoding p105 and p50. 71 refs., 5 figs., 1 tab.

Heron, E.; Deloukas, P.; van Loon, A.P.G.M. [F. Hoffmann-La Roche Limited, Basel (Switzerland)] [F. Hoffmann-La Roche Limited, Basel (Switzerland)

1995-12-10T23:59:59.000Z

126

Numerical investigation of the pulsed NF3 + H2 chemical laser using a model which includes rotational relaxation and semi-classical laser equations  

DOE Green Energy (OSTI)

Waveforms and population distributions have been calculated by a numerical model and compared with experiment for an electric-discharge-initiated, pulsed NF$sub 3$ + H$sub 2$ chemical laser. The model treats each vibrational- rotational state separately, allowing rotational relaxation between adjacent states as well as vibrational relaxation and lasing according to P-branch selection rules. Calculated waveforms agree with experiment and show several features not seen when rotational equilibrium is assumed: simultaneous lasing on many transitions, cascade behavior, spikes due to laser relaxation oscillations, non-Boltzmann rotational distributions, and ''hole burning'' in the population distributions. The calculations give insight into the physical phenomena governing the shape and duration of the waveforms. The effect of varying certain parameters, relaxation rates, temperature, pressure, and diluents, is studied. Best fit to experimental waveforms is obtained when the rotational relaxation rate and collisional line broadening rate are approximately equal at about 10 times the hard sphere collision rate. The IXION computer code, developed for these calculations, is described in detail. In addition, an analytic model is presented which accounts for major features of the total (all transitions) output waveform of the laser assuming rotational equilibrium, a steady state laser model, and constant temperature. A second computer code, MINOTAR, was developed as a general purpose chemical kinetics code. It verifies the analytic model and extends the results to adiabatic reactions where the temperature varies, and can yield waveforms using the assumptions of rotational equilibrium and a steady state laser. The MINOTAR code, being general, can also be used for chemical kinetics problems such as air pollution and combustion. (auth)

Creighton, J.R.

1975-09-01T23:59:59.000Z

127

Numerical investigation of the pulsed NF3 + H2 chemical laser using a model which includes rotational relaxation and semi-classical laser equations  

SciTech Connect

Waveforms and population distributions have been calculated by a numerical model and compared with experiment for an electric-discharge-initiated, pulsed NF$sub 3$ + H$sub 2$ chemical laser. The model treats each vibrational- rotational state separately, allowing rotational relaxation between adjacent states as well as vibrational relaxation and lasing according to P-branch selection rules. Calculated waveforms agree with experiment and show several features not seen when rotational equilibrium is assumed: simultaneous lasing on many transitions, cascade behavior, spikes due to laser relaxation oscillations, non-Boltzmann rotational distributions, and ''hole burning'' in the population distributions. The calculations give insight into the physical phenomena governing the shape and duration of the waveforms. The effect of varying certain parameters, relaxation rates, temperature, pressure, and diluents, is studied. Best fit to experimental waveforms is obtained when the rotational relaxation rate and collisional line broadening rate are approximately equal at about 10 times the hard sphere collision rate. The IXION computer code, developed for these calculations, is described in detail. In addition, an analytic model is presented which accounts for major features of the total (all transitions) output waveform of the laser assuming rotational equilibrium, a steady state laser model, and constant temperature. A second computer code, MINOTAR, was developed as a general purpose chemical kinetics code. It verifies the analytic model and extends the results to adiabatic reactions where the temperature varies, and can yield waveforms using the assumptions of rotational equilibrium and a steady state laser. The MINOTAR code, being general, can also be used for chemical kinetics problems such as air pollution and combustion. (auth)

Creighton, J.R.

1975-09-01T23:59:59.000Z

128

UTU-086779 | Open Energy Information  

Open Energy Info (EERE)

Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 STANDARD STEAM TRUST LLC Lessee 2 none provided Effective Date 12192008 Expire Date Held By...

129

UTU-086781 | Open Energy Information  

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Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 STANDARD STEAM TRUST LLC Lessee 2 none provided Effective Date 1312019 Expire Date Held By...

130

High-loop perturbative renormalization constants for Lattice QCD (II): three-loop quark currents for tree-level Symanzik improved gauge action and n_f=2 Wilson fermions  

E-Print Network (OSTI)

Numerical Stochastic Perturbation Theory was able to get three- (and even four-) loop results for finite Lattice QCD renormalization constants. More recently, a conceptual and technical framework has been devised to tame finite size effects, which had been reported to be significant for (logarithmically) divergent renormalization constants. In this work we present three-loop results for fermion bilinears in the Lattice QCD regularization defined by tree-level Symanzik improved gauge action and n_f=2 Wilson fermions. We discuss both finite and divergent renormalization constants in the RI'-MOM scheme. Since renormalization conditions are defined in the chiral limit, our results also apply to Twisted Mass QCD, for which non-perturbative computations of the same quantities are available. We emphasize the importance of carefully accounting for both finite lattice space and finite volume effects. In our opinion the latter have in general not attracted the attention they would deserve.

Brambilla, Michele

2013-01-01T23:59:59.000Z

131

The human transcription factor CP2 (TFCP2), a component of the human {gamma}-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene  

SciTech Connect

The transcription factor CP2{sup 2} has been shown to bind to several cellular and viral promoters as a homodimer. More recently, we have demonstrated that CP2 can form a heterodimer with a 45-kDa partner protein to form the stage selector protein complex (SSP). This complex binds to a proximal {gamma}-globin promoter regulatory element, the stage selector element (SSE), which appears to be involved in the competitive silencing of the {beta}-gene in the fetal stage of erythropoiesis. Similar SSP-like binding sites have been identified in the {beta}-globin promoter and regulatory elements of the {beta}-globin locus control region (LCR). The importance of the SSP complex is further emphasized by the fact that the chicken stage selector protein, NF-E4, which has been implicated in the competitive silencing of the chicken {epsilon}-globin gene, is the avian homologue of CP2. The purpose of this study is to map human CP2 genomically and define its relationship to previously identified loci. 9 refs., 1 fig.

Cunningham, J.M.; Tran, N.; Valentine, M. [St. Jude Children`s Research Hospital, Memphis, TN (United States)] [and others

1995-11-20T23:59:59.000Z

132

Mechanical Properties of Advanced NF616 Steel  

Science Conference Proceedings (OSTI)

... of TIG Welded and Laser-surface Melted SUS 304 for Nuclear Power Plants ... Statistics of Grain Boundary Crystallography in Surrogates for Oxide Nuclear ...

133

Beam Loading Computation for the IDS-NF FFAG  

SciTech Connect

I accumulate the information we have for the current baseline design for a neutrino factory to determine the maximum current we can expect at the final FFAG accelerating stage. I then determine the energy extracted from the RF cavities in the FFAG, and from that determine how much time there must be between bunch trains to restore the energy to the RF cavities so that each bunch train has the same energy at the storage ring. I also estimate the amount of energy variation from the head to the tail of the bunch train.

Berg, J.S.

2011-10-01T23:59:59.000Z

134

CMRR-NF Supplemental EIS Scoping Comments | National Nuclear...  

National Nuclear Security Administration (NNSA)

Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management...

135

Policies that specify the use of ENERGY STAR tools | ENERGY STAR  

NLE Websites -- All DOE Office Websites (Extended Search)

or lessees with a copy of the building's most recent Statement of Energy Performance. San Francisco, CA Existing Commercial Buildings Energy Performance Ordinance February 2011...

136

NVN-076826 | Open Energy Information  

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137

AZA-009187 | Open Energy Information  

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138

NVN-065558 | Open Energy Information  

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139

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140

NVN-074883 | Open Energy Information  

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141

NVN-085710 | Open Energy Information  

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142

UTU-087777 | Open Energy Information  

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143

AZA-009174 | Open Energy Information  

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144

NVN-060686 | Open Energy Information  

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145

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146

NVN-089605 | Open Energy Information  

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147

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148

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149

NVN-076139 | Open Energy Information  

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150

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151

NVN-061705 | Open Energy Information  

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152

NVN-008394 | Open Energy Information  

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(40 Acres) Case Status Expired Case Type GEOLEASENONCOMPETITI Total Acreage 160 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

153

NVN-074881 | Open Energy Information  

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154

NVN-076676 | Open Energy Information  

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155

UTU-086780 | Open Energy Information  

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156

NVN-076824 | Open Energy Information  

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157

AZA-009171 | Open Energy Information  

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158

NVN-090744 | Open Energy Information  

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159

NVN-086898 | Open Energy Information  

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160

NVN-083937 | Open Energy Information  

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OROR-065720 | Open Energy Information  

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162

NVN-077483 | Open Energy Information  

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163

NVN-074854 | Open Energy Information  

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164

NVN-086893 | Open Energy Information  

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165

NVN-085715 | Open Energy Information  

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166

NVN-074308 | Open Energy Information  

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167

NVN-074309 | Open Energy Information  

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168

NVN-074865 | Open Energy Information  

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169

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170

NVN-086897 | Open Energy Information  

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171

NVN-083942 | Open Energy Information  

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172

OROR-065728 | Open Energy Information  

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173

NVN-074196 | Open Energy Information  

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174

NVN-085716 | Open Energy Information  

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175

NVN-085709 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

176

NVN-088437 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

177

NVN-083966 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 5120 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

178

NVN-088428 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 320 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

179

NVN-076299 | Open Energy Information  

Open Energy Info (EERE)

(section) Case Status Authorized Case Type GEOLEASECOMPETITIVE Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

180

NVN-077481 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

NVN-083936 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

182

NVN-076300 | Open Energy Information  

Open Energy Info (EERE)

(section) Case Status Authorized Case Type GEOLEASECOMPETITIVE Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

183

Data:F053c97c-dd0e-4b8a-8b1a-f1000518f1eb | Open Energy Information  

Open Energy Info (EERE)

schedule after June 3, 2003, service is limited to premises at which an interruption of electric service will primarily affect only the customer, its employees, agents, lessees,...

184

Data:0d973458-281a-420e-b14f-91999a8686c1 | Open Energy Information  

Open Energy Info (EERE)

schedule after June 3, 2003, service is limited to premises at which an interruption of electric service will primarily affect only the customer, its employees, agents, lessees,...

185

Data:D68e71e3-2ba3-4220-86f8-85c167f4c53f | Open Energy Information  

Open Energy Info (EERE)

schedule after June 3, 2003, service is limited to premises at which an interruption of electric service will primarily affect only the customer, its employees, agents, lessees,...

186

Implied marketing covenant in oil and gas leases: some needed changes for the 80's  

SciTech Connect

Anticipating an increase in litigation on the lessee's duty to market natural gas which has been discovered on the leasehold, the authors review the lessee's obligation under the implied covenant to market. In light of the increased pressures on the lessee by federal regulations and the downturn in demand, any reevaluation of the nearly 100-year-old covenant should focus on the standard of conduct and standard of proof by which a lessee's marketing activities are to be judged; i.e., a review of the continued viability of the reasonably prudent operator standard. A review of case law finds that in those instances where the parties to a lease share a common interest in production, the lessee should be allowed to exercise his business judgement without fear of second guessing by judge or jury. The increase of the standard of proof to a clear and convincing evidence level achieves an acceptable compromise.

Kramer, B.M.; Pearson, C.

1986-03-01T23:59:59.000Z

187

Oil and Gas- Leases to remove or recover (Pennsylvania)  

Energy.gov (U.S. Department of Energy (DOE))

This act states that a lease or agreement conveying the right to remove or recover oil, natural gas or gas of any other designation from lessor to lessee shall not be valid if such lease does not...

188

Technical Support Document: Development of the Advanced Energy Design Guide for Grocery Stores--50% Energy Savings  

DOE Green Energy (OSTI)

This report provides recommendations that architects, designers, contractors, developers, owners, and lessees of grocery store buildings can use to achieve whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004.

Hale, E. T.; Macumber, D. L.; Long, N. L.; Griffith, B. T.; Benne, K. S.; Pless, S. D.; Torcellini, P. A.

2008-09-01T23:59:59.000Z

189

AZA-009176 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2486.88 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

190

AZA-009180 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 3032.28 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

191

NVN-075005 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 625.68 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF RECLAMATIO Lessee 1...

192

AZA-009173 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2503.48 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

193

AZA-009184 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2017.7 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

194

AZA-009188 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2420.28 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

195

AZA-009189 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 1252.24 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

196

IDI-036679 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 3012.36 Bid PriceAcre Managing Field Office none provided Surface Manager PRIVATE LANDS Lessee 1 AGUA...

197

AZA-009183 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2012.92 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

198

AZA-009172 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2220.99 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

199

AZA-009192 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2543.12 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

200

UTU-086774 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 1314.08 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

NVN-076827 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 1015.22 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

202

UTU-087776 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 5085.68 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

203

NVN-086889 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 5024.506 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

204

NVN-060688 | Open Energy Information  

Open Energy Info (EERE)

Type 1 Case Status Authorized Case Type GEOLEASECOMPETITIVE Total Acreage 1236.75 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

205

NVN-076821 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2682.56 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

206

AZA-009181 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 1990.98 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

207

NVN-060687 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLEASECOMPETITIVE Total Acreage 640.36 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

208

AZA-009182 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2010.24 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

209

AZA-009179 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2030.04 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

210

NVN-083929 | Open Energy Information  

Open Energy Info (EERE)

Type Lot Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 4836 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

211

AZA-009178 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2031.26 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

212

AZA-009185 | Open Energy Information  

Open Energy Info (EERE)

Type Lot Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560.2 Bid PriceAcre Managing Field Office none provided Surface Manager FOREST SERVICE Lessee 1 HUNT...

213

UTU-086755 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 5119.92 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

214

UTU-086778 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 5119.92 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

215

NVN-088416 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 1263.23 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

216

NVN-076823 | Open Energy Information  

Open Energy Info (EERE)

Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 1897.2 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

217

NVN-083934 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2038.32 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

218

NVN-088435 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2022.16 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

219

NVN-083931 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2123.1 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

220

UTU-086773 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 4337.48 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

UTU-086761 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 799.13 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

222

NVN-053372 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 160 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

223

NVN-065561 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 360 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

224

NVN-010922 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 80 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

225

NVN-074855 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 933.5 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

226

OROR-065722 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2835.92 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

227

NVN-075233 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 1868.45 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

228

NVN-086905 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 1880.48 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

229

NVN-085722 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSECOMPPOST2005 Total Acreage 4360 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

230

NVN-085723 | Open Energy Information  

Open Energy Info (EERE)

Type Lot Case Status Closed Case Type GEOLSECOMPPOST2005 Total Acreage 4876.5 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

231

NVN-076301 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLEASECOMPETITIVE Total Acreage 2503.7 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

232

NVN-085724 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSECOMPPOST2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

233

NVN-085726 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 4435.6 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

234

NVN-076298 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLEASECOMPETITIVE Total Acreage 1912.02 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

235

NVN-042707 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 1796.67 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

236

NVN-083930 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 4291.68 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

237

NVN-088436 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2490.52 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

238

NVN-083939 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2542.64 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

239

OROR-065723 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2206.85 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

240

NVN-086885 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 1356.76 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

NVN-040355 | Open Energy Information  

Open Energy Info (EERE)

Type Lot Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 34.77 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

242

NVN-086899 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 3810.02 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

243

NVN-083932 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2549.4 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

244

NVN-083933 | Open Energy Information  

Open Energy Info (EERE)

Case Data Survey Type PROT Case Status Authorized Case Type Total Acreage 2,560.00 Bid PriceAcre Managing Field Office BLM Stillwater Field Office Surface Manager BLM Lessee 1...

245

NVN-085819X | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Authorized Case Type GEOUNITAGREEMENT Total Acreage 7426.1 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF RECLAMATIO Lessee 1...

246

OROR-065721 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 4071.67 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

247

NVN-085711 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 5000.84 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

248

NVN-018423 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSECOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1...

249

QCD THERMODYNAMICS WITH NF=2+1 NEAR THE CONTINUUM LIMIT AT REALISTIC QUARK MASSES.  

Science Conference Proceedings (OSTI)

We report on our study of QCD thermodynamics with 2 + 1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on N{sub t} = 4 and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of m{sub q}/m{sub s} = 0.05 - 0.4. The lightest quark mass corresponds to a pion mass of about 150 MeV.

UMEDA, T.

2006-07-23T23:59:59.000Z

250

Centr um voor Wi skunde en I nf or mati ca Modelling, AnalysisandSimulation  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . . . . . . 31 iii #12;Contents CAFE Final Report Volume II III Protocols 33 6 Notation and De nitions 35 6.1 and Simulation CAFE project _ Final report volume II Secure protocols and architecture Edited by A. Bosselaers, R;CAFE Project - Final Report Volume II Secure Protocols and Architecture Edited by A. Bosselaers, R

Schoenmakers, Berry

251

e its go right to the heart nf the basis on which  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

gas at the low- est cost-of-service to U.S. consumers-probably below the cost of imported oil and substantially below the costs of other fuel alter- natives. The average price of...

252

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network (OSTI)

dioxane…. ……………… 3.4. Water chemistry: Concentration, pH,4.3.1. Effect of water chemistry on membrane water4.3.2. Effect of water chemistry on EG rejection…………………. …..

Mo, Yibing

2013-01-01T23:59:59.000Z

253

Review of NF-IDS Targets Work Programme Status C. Densham, RAL, 17 November 2009  

E-Print Network (OSTI)

and services ? e) Cost of mercury system ? f) Cost of remote handling systems including shielding required ? g implications for TS shielding CJD, OC, PL (RAL) 4.3.7 Investigate remote handling concepts and cost Dump iv. Time to repair/replace target system, Remote Handling complexity v. Maintenance intervals vi

McDonald, Kirk

254

A Combined NF-IDS and EUROnu Targets Work Programme Chris Densham, Marco Zito, Harold Kirk  

E-Print Network (OSTI)

i. Target system active volume ­ civil engineering, shielding and building costs ii. Remote handling and services e) Cost of mercury system f) Cost of remote handling systems including shielding required g) Any implications for TS TBD #12;shielding 4.3.10 Investigate remote handling concepts, reliability and cost RE

McDonald, Kirk

255

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network (OSTI)

water by GAC adsorption, Desalination, 210 (2007) 215-224. [with strong oxidants, Desalination, 176 (2005) 37-45. [49]water RO membranes, Desalination, 235 (2009) 44-57. [19] G.

Mo, Yibing

2013-01-01T23:59:59.000Z

256

Heavy Quark Physics in Nf = 2 QCD ? CP-PACS Collaboration:  

E-Print Network (OSTI)

We present a preliminary analysis of the heavy-heavy spectrum and heavy-light decay constants in full QCD, using a tadpole-improved SW quark action and an RG-improved gauge action on a 16 3 × 32 lattice with four sea quark masses corresponding to m?/m? ? 0.8, 0.75, 0.7, 0.6 and a ?1 ? 1.3 GeV. We focus particularly on the effect of sea quarks on these observables. 1.

unknown authors

1998-01-01T23:59:59.000Z

257

Insights from reconstructing cellular networks in transcription, stress, and cancer  

E-Print Network (OSTI)

M. & Ghosh, S. Crosstalk in NF-kB signaling pathways. Natcomprehensive characterization of NF-kB family DNA binding.12 CHAPTER 1 NF-kB

Ke, Eugene Yunghung; Ke, Eugene Yunghung

2012-01-01T23:59:59.000Z

258

CtjNf.~1'-1'6....r .:tt33 J C7b/(j7/IS-  

E-Print Network (OSTI)

University Princeton, New Jersey 08540 (Submitted to the XVIII Conf. in High-Energy Physics, Tbilisi, USSR

McDonald, Kirk

259

On the Use of Thermal NF3 as the Fluorination and Oxidation Agent in Treatment of Used Nuclear Fuels  

SciTech Connect

This paper presents results of our investigation on the use of nitrogen trifluoride as the fluorination or fluorination/oxidation agent for use in a process for separating valuable constituents from used nuclear fuels by employing the volatility of many transition metal and actinide fluorides. Nitrogen trifluoride is less chemically and reactively hazardous than the hazardous and aggressive fluorinating agents used to prepare uranium hexafluoride and considered for fluoride volatility based nuclear fuels reprocessing. In addition, nitrogen trifluoride’s less aggressive character may be used to separate the volatile fluorides from used fuel and from themselves based on the fluorination reaction’s temperature sensitivity (thermal tunability) rather than relying on differences in sublimation/boiling temperature and sorbents. Our thermodynamic calculations found that nitrogen trifluoride has the potential to produce volatile fission product and actinide fluorides from candidate oxides and metals. Our simultaneous thermogravimetric and differential thermal analyses found that the oxides of lanthanum, cerium, rhodium, and plutonium fluorinated but did not form volatile fluorides and that depending on temperature volatile fluorides formed from the oxides of niobium, molybdenum, ruthenium, tellurium, uranium, and neptunium. We also demonstrated near-quantitative removal of uranium from plutonium in a mixed oxide.

Scheele, Randall D.; McNamara, Bruce K.; Casella, Andrew M.; Kozelisky, Anne E.

2012-05-01T23:59:59.000Z

260

Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after  

E-Print Network (OSTI)

studies, artificial aquifer storage and recovery, waterflood surveillance, gas production and CO2. Brady, C. L. V. Aiken, and J. E. Seib- ert, 2007, The 4D mictogravity method for waterflood surveillance

Freger, Viatcheslav "Slava"

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

QCD thermodynamics with $N_f=2+1$ near the continuum limit at realistic quark masses  

E-Print Network (OSTI)

We report on our study of QCD thermodynamics with 2+1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on $N_t=4$ and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of $m_q/m_s=0.05-0.4$. The lightest quark mass corresponds to a pion mass of about 150 MeV.

Takashi Umeda

2006-10-03T23:59:59.000Z

262

Burned Area Emergency Response (BAER) Assessment FINAL Specialist Report – GEOLOGIC HAZARDS Station Fire, Angeles N.F.  

E-Print Network (OSTI)

Three USFS BAER Team geologists assessed increased risks from geologic hazards within the 161,000 acre Station Fire. Watershed response to moderate and high severity burned areas will depend on storm intensity and duration, but is likely to be threatening to life, property and natural resources, and costly. Even small storms have a high to severe relative hazard rating for dangerous debris flows across most of the burned area. Most treatments to reduce debris flow risk were deemed not feasible, not effective, and cost prohibitive. Rockfall, debris slides and dry ravel will add additional hazard and sediment bulk to flood flows. Debris basins will fill quickly, and could overtop and damage downstream communities and infrastructure. Debris storage sites are lacking. Abandoned mines are exposed and add additional hazards. Treatment options are few, and warning systems and public education are critical.

Jerry Degraff Geologist; Sierra N. F; Jonathan Yonni; Schwartz Geologist; Angeles N. F

2009-01-01T23:59:59.000Z

263

Low level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts  

E-Print Network (OSTI)

Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation remain unclear. In this study, we isolated murine embryonic fibroblasts (MEF) from ...

Hamblin, Michael R.

264

NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B  

E-Print Network (OSTI)

correction of random coil NMR chemical shifts. J Am Chem Socproteins by multidimensional NMR. Biochemistry Bax, A. ,ensemble interpretation of NMR dipolar couplings without

Cervantes, Carla F.

2010-01-01T23:59:59.000Z

265

KT McDonald IDS-NF Plenary Meeting (Glasgow) Apr 19, 2012 1 The High-Power-Target System  

E-Print Network (OSTI)

Cryogenics Diagnostics Controls and Interlocks Health and Safety Mechanical Decommissioning Remote Handling and Hot Cells ######## UScaled from LBNE Buildings, tunnels and Infrastructure ######## Scaled from LBNE,405,475 1.06.06 - Target Utility Systems 10,730,099 1.06.07 - Remote Handling Systems 14,348,362 1

McDonald, Kirk

266

DOI: 10.1126/science.1164265 , 407 (2009);324Science  

E-Print Network (OSTI)

). Similarly, single nucleotide differences in NF-kB binding sequences determine cofactor specificity for NF-kB

Yamamoto, Keith

267

Environmental Compliance 2-1 2. Environmental Compliance  

E-Print Network (OSTI)

operate under leasing arrangements at the ETTP under the DOE Rein- dustrialization Program. LesseesEnvironmental Compliance 2-1 2. Environmental Compliance It is DOE-ORO and National Nuclear, executive orders, DOE orders (as incorporated into the op- erating contracts), and best management practices

Pennycook, Steve

268

Environmental Compliance 2-1 2. Environmental Compliance  

E-Print Network (OSTI)

at the ETTP under the DOE Rein- dustrialization Program. Lessees are accountable for complying with all facilities at the ETTP site have been leased to private entities over the past several years through the DOEEnvironmental Compliance 2-1 2. Environmental Compliance It is DOE-ORO and NNSA policy to conduct

Pennycook, Steve

269

Purdue University Cooperative Extension Service West Lafayette, Indiana Agricultural  

E-Print Network (OSTI)

the rights to oil and gas exploration and produc- tion. Granting of rights to test-drill and to produce oil. Landowners should also become fully informed about the rights and duties of oil and gas exploration and gas is an important transfer of property rights. One might say that the oil and gas producer/ lessee

270

The non-canonical NFkappaB pathway modulates inflammatory signaling by the canonical NFkappaB pathway  

E-Print Network (OSTI)

Nomenclature Initial mM Location IkBa IkBa IkBa:NF-kBIkBa:NF-kB IkBa:IKKIkBa:IKK:NF-kB IkBa mRNA IkBb IkBb IkBb:NF-kB IkBb:NF-?B

Shih, Feng-Sheng

2011-01-01T23:59:59.000Z

271

Field Mapping At Raft River Geothermal Area (1993) | Open Energy  

Open Energy Info (EERE)

Exploration Activity: Field Mapping At Raft River Geothermal Area (1993) Exploration Activity: Field Mapping At Raft River Geothermal Area (1993) Exploration Activity Details Location Raft River Geothermal Area Exploration Technique Field Mapping Activity Date 1993 Usefulness not indicated DOE-funding Unknown Exploration Basis To determine the importance of Early to Middle Miocene period in the northern Basin and Range region. Notes New apatite fission track cooling age and track length data, supplemented by other information, point to the Early to Middle Miocene as an additional time of very significant extension-induced uplift and range formation. Many ranges in a 700-km-long north-south corridor from the Utah-Nevada-Idaho border to southernmost Nevada experience extension and major exhumation in Early to Middle Miocene time. Reconnaissance apatite ages from the Toiyabe

272

Field Mapping At Northern Basin and Range Geothermal Region (1993) | Open  

Open Energy Info (EERE)

Geothermal Region (1993) Geothermal Region (1993) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Field Mapping At Northern Basin and Range Geothermal Region (1993) Exploration Activity Details Location Northern Basin and Range Geothermal Region Exploration Technique Field Mapping Activity Date 1993 Usefulness not indicated DOE-funding Unknown Notes New apatite fission track cooling age and track length data, supplemented by other information, point to the Early to Middle Miocene as an additional time of very significant extension-induced uplift and range formation. Many ranges in a 700-km-long north-south corridor from the Utah-Nevada-Idaho border to southernmost Nevada experience extension and major exhumation in Early to Middle Miocene time. Reconnaissance apatite ages from the Toiyabe

273

Curcumin: A Review of Anti-Cancer Properties and Therapeutic Activity in Head & Neck Squamous Cell Carcinoma  

E-Print Network (OSTI)

Curcumin Inhibition of NF-kB activation, Suppression ofand other angionegic decreased NF-kB activation factors, Up-of transcription factor NF-kB is suppressed by curcumin (

Wilken, Reason; Veena, Mysore S; Wang, Marilene B; Srivatsan, Eri S

2011-01-01T23:59:59.000Z

274

Mitochondrial Protein Influx in Low-dose Radiation-mediated Radioprote...  

NLE Websites -- All DOE Office Websites (Extended Search)

radioprotection via activation of the prosurvival network of factor NF-kappa B (NF-kB). We have reported that blocking NF-kB activation is able to inhibit 10cGy x-ray-...

275

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor  

E-Print Network (OSTI)

1 activity suppresses NF-kB-dependent gene transcription andinhibition suppresses NF-kB- dependent gene transcription inof PARP inhibitors to block NF-kB - mediated inflammatory

2012-01-01T23:59:59.000Z

276

The HB22.7 Anti-CD22 Monoclonal Antibody Enhances Bortezomib-mediated Lymphomacidal Activity in a Sequence Dependent Manner  

E-Print Network (OSTI)

the accumulation of NF-kB [3,4], increased ROS generation [via inhibition of NF-kB activation [29]. Interestingly,by bortezomib also inhibits NF-kB activation [3,4], which in

2011-01-01T23:59:59.000Z

277

Particulate Matter in Polluted Air May IncreaseBiomarkers of Inflammation in Mouse Brain  

E-Print Network (OSTI)

sample and unlabelled NF-kB consensus oligonu- cleotide, NSCendothelial cells: role of NF-kB activation. J Immunol 2001;EN, Krappmann D, Scheidereit C. NF-kB and the innate immune

Bondy, Stephen Bondy C

2005-01-01T23:59:59.000Z

278

Type I Interferon is Not Just for Viruses: Cytosolic Sensing of Bacterial Nucleic Acids  

E-Print Network (OSTI)

the nucleus and assemble with NF-kB and other transcriptionactivation of IRF3/7, NF-kB, and MAP kinases (Yoneyama andtype I IFNs primarily via NF-kB, which synergizes with other

Monroe, Kathryn McGee

2011-01-01T23:59:59.000Z

279

Advances in computational mass spectrometry : phosphoprotoemics and proteogenomics  

E-Print Network (OSTI)

and phosphorylation mediated NF-KB activiation. Four histoneto be activated, or relay the signal. In NF-KB signaling, atranscription factor (NF-KB) is held inactive outside the

Payne, Samuel Harris

2008-01-01T23:59:59.000Z

280

Discovery and characterization of the mechanisms of a vaccinia viral Bcl-2 homolog, F1L, on Inhibition of caspase-9 and NLRP1  

E-Print Network (OSTI)

a stably integrated NF-kB-driven secreted embryonic alkalineprior to VACV infection. NF-kB activation in THP-1-Bluecells (ATCC; InvivoGen), NF-kB activation was evaluated by

Yu, Chi Wang

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Mechanisms of regulation in the interferon factor 3 (IRF- 3) pathway  

E-Print Network (OSTI)

gene induction, whereas NF-kB- dependent gene inductioncytokines through the NF-kB pathway 4 , hinting at theprotein) and leads to NF-kB activation 2 . This pathway is

Limmer, Kirsten

2008-01-01T23:59:59.000Z

282

Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?  

E-Print Network (OSTI)

and one of the key factors implicated has been NF-kB [78].Nuclear translocation of NF-kB is associated withSong et al. inhibited NF-kB selectively in the endothelium

2011-01-01T23:59:59.000Z

283

Effects of melatonin and age on gene expression in mouseCNS using microarray analysis  

E-Print Network (OSTI)

gene contains an activation site for NF-kB (Cowland et al. ,and levels of activated NF-kB increase in murine cortex withThus, increased levels of NF-kB activation in the aged brain

Bondy, Stephen Bondy C

2007-01-01T23:59:59.000Z

284

Sumoylation strategies in regulated repression by nuclear receptors and in function of tumor metastasis suppressor genes  

E-Print Network (OSTI)

links gene expression by NF-kB and ?-amyloid precursorinteracts with and inhibits NF-kB in human colon and breastby KAI1. Since KAI1 is a NF-kB target gene, its message

Cai, Ling

2008-01-01T23:59:59.000Z

285

Activation of nucleic acid-sensing Toll-like receptors requires cleavage by endolysosomal proteases: a mechanism to avoid autoimmunity  

E-Print Network (OSTI)

a) RAW cells expressing an NF-kB luciferase reporter wereTRIF to induce production of NF-kB elicited transcripts andand a plasmid encoding an NF-kB luciferase reporter (with 5

Ewald, Sarah Elisabeth

2010-01-01T23:59:59.000Z

286

Self/Non-self Discrimination by Toll-like Receptor 9  

E-Print Network (OSTI)

cells stably expressing a NF-kB luciferase reporter and thewith LPS or CpG. Bottom, NF-kB luciferase activity measuredcells stably expressing a NF-kB luciferase reporter and TLR9

Mouchess, Maria Luz

2011-01-01T23:59:59.000Z

287

Plant and animal sensors of conserved microbial signatures.  

E-Print Network (OSTI)

a nuclear factor kB (NF-kB) re- sponse, is a key transducerof one human TLR induced NF-kB activation in mammaliansee SOM). Plants do not have NF-kB–related transcrip- tion

Ronald, Pamela C; Beutler, Bruce

2010-01-01T23:59:59.000Z

288

Molecular mechanisms of ligand-dependent repression by the estrogen receptor and derepression by inflammatory signaling  

E-Print Network (OSTI)

links gene expression by NF-kB and b-amyloid precursorsuch as Receptor Activator of NF-kB (RANK), p75 neurotrophinby the p50 ho- modimer of NF-kB DNA binding factors by

Bourk, Eliot Michael

2010-01-01T23:59:59.000Z

289

Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation-Induced Senescence of Human Mesenchymal Stem Cells  

E-Print Network (OSTI)

cytokines/chemokines are NF- kB responsive genes. These dataand suggested the possibility of NF-kB activation leadingto secretion of NF-kB responsive chemokines. Cytoskeleton

Wang, Daojing

2010-01-01T23:59:59.000Z

290

Evolution of the Oligopeptide Transporter (OPT) family  

E-Print Network (OSTI)

evaluation. Name Publication NF-kB Tian et al. 2005a 173expressed mutant IkB blocking NF-kB signaling (labeled “based selection in (a) NF-kB dataset, (b) ALL dataset, (c)

Gomolplitinant, Kenny Matee

2010-01-01T23:59:59.000Z

291

Toll-like Receptor Signaling and its Effects on Microbial Pathogenesis  

E-Print Network (OSTI)

of transcription factors (NF-kB, AP-1, IRFs) that coordinatestably expressing an NF-kB- luciferase reporter construct.in robust induction of NF-kB, which we attributed to

Arpaia, Nicholas

2011-01-01T23:59:59.000Z

292

Sample-Specific Cancer Pathway Analysis Using PARADIGM  

E-Print Network (OSTI)

cation of response to QNZ (an NF-KB inhibitor) in the breastfor the combination of QNZ (an NF-KB inhibitor) and E2F3.studies have shown that NF-KB may activate E2F family

Benz, Stephen Charles

2012-01-01T23:59:59.000Z

293

Trichoepithelioma  

E-Print Network (OSTI)

that negatively regulates NF-kB activation by TNFR familycomponent proteins in the NF-kB and JNK signaling pathways.regulate the cytokine-induced NF-kB pathway for cellular

Johnson, Hillary; Robles, Mirin; Kamino, Hideko; Walters, Ruth F; Lee, Arnold; Sanchez, Miguel

2008-01-01T23:59:59.000Z

294

Z. Geomorph. N.F. Suppl.-Vol.146 235-251 Berlin Stuttgart November 2006 Geologic Impacts of the 2004 Indian OceanTsunami on Indonesia,  

E-Print Network (OSTI)

of the 2004 Indian OceanTsunami on Indonesia, Sri Lanka, and the Maldives Bruce M. Richmond, Bruce E in the eastern Indian Ocean near northern Sumatra, Indonesia.The resulting tsunami was measured globally and had.1) with an epicenter located under the seafloor in the eastern Indian Ocean near northern Sumatra, Indonesia

295

Computational tools based on energy landscape theory to predict structurally diverse ensembles of transcription factors  

E-Print Network (OSTI)

E. (2004) Thermodynamics and kinetics of the nf-kb/ikband nf-kb/dna interactions, Biophysical Journal 86, 513a. [

Lätzer, Joachim

2007-01-01T23:59:59.000Z

296

Metabolic Regulation by Lipid Activated Receptors  

E-Print Network (OSTI)

of iKB, which limits Nf-KB signaling(31, 32). PPAR ?VCAM expression through nf-kb and AP1 signaling when taken

Ruby, Maxwell A.

2010-01-01T23:59:59.000Z

297

A High-throughput Screening Approach Identifies Selective Regulators of Il12b Transcription  

E-Print Network (OSTI)

TLR4, in contrast to NF-kB and AP-1, whose activities aresignaling pathways, such as NF-kB and MAP kinase pathways,

Doty, Kevin Richard

2012-01-01T23:59:59.000Z

298

Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks  

E-Print Network (OSTI)

in CF airways Transcription NF-kB signalling pathways Immunesilencing NGF activation of NF-kB EC-MTG Cytoskeleton

Ray, Monika; Zhang, Weixiong

2010-01-01T23:59:59.000Z

299

Shadow Enhancers Provide Precision and Robustness for the Patterning of the Precellular Drosophila Embryo  

E-Print Network (OSTI)

related to mammalian NF-kB. Dorsal controls DV patterningfactor related to mammalian NF-kB (Rushlow et al. 1989; Roth

Perry, Michael W.

2011-01-01T23:59:59.000Z

300

Structural Studies of Calcium/Calmodulin Depenedent Protein Kinase II Activation  

E-Print Network (OSTI)

activation. For example, NF-kB and Ras have been shown toet al. , 2005), and the NF-kB pathway (Dolmetsch et al. ,

Chao, Luke H.

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Pancreatitis and pancreatic cancer in two large pooled case–control studies  

E-Print Network (OSTI)

released during pancreatitis, NF-KB, IL-8, COX-2, and TNF-54]. The involvement of NF-KB is of particular interest as

Bracci, Paige M.; Wang, Furong; Hassan, Manal M.; Gupta, Samir; Li, Donghui; Holly, Elizabeth A.

2009-01-01T23:59:59.000Z

302

Anakinra-responsive lichen planus in a woman with Erdheim-Chester disease: a therapeutic enigma  

E-Print Network (OSTI)

cyclosporine A on TLRA/NF-kB signaling pathway activation inof the pro-inflammatory, NF-kB-dependent cytokines: TNF-

Cohen, Philip R; Kurzrock, Razelle

2014-01-01T23:59:59.000Z

303

Conference Highlights of the 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses,4-8 June 2011, Leuven, Gembloux, Belgium  

E-Print Network (OSTI)

subcellular localization and NF-kB activation. RetrovirologyTax sumoylation in Tax-induced NF-kB activation in T cells.

2011-01-01T23:59:59.000Z

304

NK1 (substance P) receptor  

E-Print Network (OSTI)

nuclear factor- kappaB (NF-kB) and leads to the productionits expression is controlled by NF-kB (Patel et al. 2005;

Goldsmith, Laura E; Kwatra, Madan M

2012-01-01T23:59:59.000Z

305

Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress  

E-Print Network (OSTI)

Signaling pathway: Nrf2 MAPK NF-kB Genetic response:ARE AP NF-kB Mitochondrial perturbation PT pore Figure 4

Araujo, Jesus A; Nel, Andre E

2009-01-01T23:59:59.000Z

306

Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes  

E-Print Network (OSTI)

of microtubes activated NF-kB. J Cell Biol 1995: 128: 1111–regulation of wound healing? NF-kB activation in cultured

Shi, B; Isseroff, R R

2005-01-01T23:59:59.000Z

307

Host factor regulation of Toxoplasma gondii growth and differentiation  

E-Print Network (OSTI)

has been shown that the NF-kB subunit p65 is phosphorylatedas a consequence of NF-kB signaling upon parasite

Weilhammer, Dina

2010-01-01T23:59:59.000Z

308

2008 Form 3468  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

545-0155 545-0155 Investment Credit Form 3468 ᮣ Attach to your tax return. See instructions. Attachment Sequence No. 52 Identifying number Name(s) shown on return 1 For Paperwork Reduction Act Notice, see instructions. Form 3468 (2008) c × 30% (.30) × 30% (.30) 5 Cat. No. 12276E If you are claiming the investment credit as a lessee based on a section 48(d) (as in effect on November 4, 1990) election, provide the following information. If you acquired more than one property as a lessee, attach a statement showing the information below. (99) Name of lessor $ $ b $ $ Department of the Treasury Internal Revenue Service 2 5a 5b 5c × $1,000 5d 5e × 30% (.30) × $3,000 Kilowatt capacity of property in f above ᮣ g h Enter the lesser of line 5f or 5g 3 4 2008

309

NVN-077247 | Open Energy Information  

Open Energy Info (EERE)

7 7 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-077247 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LEASE_NONCOMPETITI Total Acreage 1020 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 REESE RIVER GEO POWER LLC Lessee 2 none provided Effective Date 10/31/2013 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EXPIRES Most Recent Action Date 10/31/2013 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0240N Range 0430E Section 34 Aliquot nene,swse Retrieved from "http://en.openei.org/w/index.php?title=NVN-077247&oldid=663706" Category: BLM Geothermal Case What links here

310

NVN-076825 | Open Energy Information  

Open Energy Info (EERE)

5 5 Case Data Survey Type Aliquot Part (40 Acres) Case Status "Relinguished" is not in the list of possible values (Authorized, Cancelled, Closed, Expired, Pending, Rejected, Relinquished, Withdrawn, Authorized, Cancelled, Closed, Expired, Pending, Rejected, Relinquished, Withdrawn) for this property. Case Type GEO_LSE_NONCOMP_PRE_2005 Total Acreage 2659.07 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 ORMAT NEVADA INC Lessee 2 none provided Effective Date 8/31/2016 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EXPIRES Most Recent Action Date 8/31/2016 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0120N Range 0330E Section 13 Aliquot w2e2,w2

311

IDI-035812 | Open Energy Information  

Open Energy Info (EERE)

IDI-035812 IDI-035812 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: IDI-035812 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 1739.4 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 AGUA CALIENTE LLC C-O AMG N Lessee 2 none provided Effective Date 8/1/2007 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 8/1/2007 Location Information Geothermal Resource Area Meridian 8 State(s) Idaho Township 0110N Range 0030W Section 6 Aliquot s2ne,senw,e2sw,se Retrieved from "http://en.openei.org/w/index.php?title=IDI-035812&oldid=663882" Category: BLM Geothermal Case

312

NVN-085712 | Open Energy Information  

Open Energy Info (EERE)

12 12 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-085712 Case Data Survey Type Unsurveyed - uprotracted Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 2706.92 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 ENEL GEOTHERMAL LLC Lessee 2 none provided Effective Date 8/5/2008 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action BID RECEIVED Most Recent Action Date 8/5/2008 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0160N Range 0300E Section 1 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-085712&oldid=666717" Category: BLM Geothermal Case What links here

313

NVN-086892 | Open Energy Information  

Open Energy Info (EERE)

Page Page Edit with form History Facebook icon Twitter icon » NVN-086892 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-086892 Case Data Survey Type All (section) Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 640 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 TGP COYOTE CANYON LLC Lessee 2 none provided Effective Date 9/1/2009 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 9/1/2009 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0240N Range 0360E Section 21 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-086892&oldid=664342"

314

NVN-053371 | Open Energy Information  

Open Energy Info (EERE)

1 1 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-053371 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LSE_COMP_PRE_2005 Total Acreage 560 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 SODA LAKE RESRC PRTNRSHP Lessee 2 none provided Effective Date 10/1/1975 Expire Date Held By Production (HBP) HELD BY PROD-ALLOCATED HBP Date 8/1/1990 RoyaltyRate 10% - 5% - 5% Most Recent Action RLTY RATE -10%- Most Recent Action Date 10/1/1975 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0200N Range 0280E Section 28 Aliquot s2 Retrieved from "http://en.openei.org/w/index.php?title=NVN-053371&oldid=666665"

315

NVN-083967 | Open Energy Information  

Open Energy Info (EERE)

7 7 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-083967 Case Data Survey Type All (section) Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 2340 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 WILMINGTON TRUST CO TRUSTEE Lessee 2 none provided Effective Date 8/14/2007 Expire Date Held By Production (HBP) HELD BY PROD-ALLOCATED HBP Date 6/14/1988 RoyaltyRate Most Recent Action BID RECEIVED Most Recent Action Date 8/14/2007 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0200N Range 0450E Section 21 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-083967&oldid=667980" Category: BLM Geothermal Case

316

NVN-074868 | Open Energy Information  

Open Energy Info (EERE)

8 8 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-074868 Case Data Survey Type All (section) Case Status Closed Case Type GEO_LSE_NONCOMP_PRE_2005 Total Acreage 2560 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 ORMAT NEVADA INC Lessee 2 none provided Effective Date 10/1/2002 Expire Date Held By Production (HBP) HBP Date RoyaltyRate 10% - 5% - 5% Most Recent Action RLTY RATE -10%- Most Recent Action Date 10/1/2002 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0290N Range 0410E Section 23 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-074868&oldid=669228" Category: BLM Geothermal Case What links here

317

NVN-086890 | Open Energy Information  

Open Energy Info (EERE)

6890 6890 Case Data Survey Type All (section) Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 5120 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 TGP NEW YORK CANYON LLC Lessee 2 none provided Effective Date 8/31/2019 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EXPIRES Most Recent Action Date 8/31/2019 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0250N Range 0350E Section 9 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-086890&oldid=665765" Category: BLM Geothermal Case What links here Related changes Special pages Printable version Permanent link Browse properties 429 Throttled (bot load)

318

NVN-040353 | Open Energy Information  

Open Energy Info (EERE)

3 3 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-040353 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LSE_COMP_PRE_2005 Total Acreage 40 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 BRADY POWER PARTNERS Lessee 2 none provided Effective Date 4/1/1986 Expire Date Held By Production (HBP) HELD BY PROD-ALLOCATED HBP Date 12/20/1985 RoyaltyRate 10% - 5% - 5% Most Recent Action RLTY RATE -10%- Most Recent Action Date 4/1/1986 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0230N Range 0260E Section 36 Aliquot sese Retrieved from "http://en.openei.org/w/index.php?title=NVN-040353&oldid=662079

319

NVN-017282 | Open Energy Information  

Open Energy Info (EERE)

82 82 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-017282 Case Data Survey Type All (section) Case Status Authorized Case Type GEO_LEASE_COMPETITIVE Total Acreage 2560 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 TGP COYOTE CANYON LLC Lessee 2 none provided Effective Date 11/1/1977 Expire Date Held By Production (HBP) HELD BY LOCATION IN A PRODUCING UNIT HBP Date 6/14/1987 RoyaltyRate 1.75% - 3.5% Most Recent Action ROYALTY RATE -1 Most Recent Action Date 11/1/1977 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0240N Range 0360E Section 11 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-017282&oldid=668280

320

NVN-077482 | Open Energy Information  

Open Energy Info (EERE)

2 2 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-077482 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LSE_NONCOMP_PRE_2005 Total Acreage 1510 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 WILMINGTON TRUST CO TRUSTEE Lessee 2 none provided Effective Date 8/1/2005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 8/1/2005 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0260N Range 0400E Section 3 Aliquot s2n2,s2 Retrieved from "http://en.openei.org/w/index.php?title=NVN-077482&oldid=666890" Category: BLM Geothermal Case What links here

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

NVN-048022 | Open Energy Information  

Open Energy Info (EERE)

NVN-048022 NVN-048022 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-048022 Case Data Survey Type Lot Case Status Authorized Case Type GEO_LSE_COMP_PRE_2005 Total Acreage 798.94 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 SODA LAKE RESRC PRTNRSHP Lessee 2 none provided Effective Date 5/1/1988 Expire Date Held By Production (HBP) HELD BY PROD-ALLOCATED HBP Date 12/27/1987 RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 5/1/1988 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0190N Range 0280E Section 3 Aliquot 1-2 Retrieved from "http://en.openei.org/w/index.php?title=NVN-048022&oldid=669217" Category: BLM Geothermal Case

322

UTU-086756 | Open Energy Information  

Open Energy Info (EERE)

UTU-086756 UTU-086756 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: UTU-086756 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 5120 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 ORNI 48 LLC Lessee 2 none provided Effective Date 1/31/2019 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EXPIRES Most Recent Action Date 1/31/2019 Location Information Geothermal Resource Area Meridian 26 State(s) Utah Township 0140S Range 0120W Section 22 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=UTU-086756&oldid=667910" Category: BLM Geothermal Case What links here Related changes

323

NVN-090069 | Open Energy Information  

Open Energy Info (EERE)

form form View source History View New Pages Recent Changes All Special Pages Semantic Search/Querying Get Involved Help Apps Datasets Community Login | Sign Up Search Page Edit with form History Facebook icon Twitter icon » NVN-090069 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-090069 Case Data Survey Type Lot Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 2639.23 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF RECLAMATIO Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 11/1/2008 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 11/1/2008 Location Information Geothermal Resource Area Meridian 21

324

NVN-058196 | Open Energy Information  

Open Energy Info (EERE)

NVN-058196 NVN-058196 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-058196 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LEASE_NONCOMPETITI Total Acreage 663.76 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 NGP BLUE MOUNTAIN I LLC Lessee 2 none provided Effective Date 4/1/1994 Expire Date Held By Production (HBP) HELD BY PROD-Actual HBP Date 8/1/1990 RoyaltyRate 1.75% - 3.5% Most Recent Action ROYALTY RATE -1 Most Recent Action Date 4/1/1994 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0360N Range 0340E Section 14 Aliquot e2 Retrieved from "http://en.openei.org/w/index.php?title=NVN-058196&oldid=667050"

325

UTU-086775 | Open Energy Information  

Open Energy Info (EERE)

UTU-086775 UTU-086775 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 4499.48 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 ORNI 48 LLC Lessee 2 none provided Effective Date 1/12/2009 Expire Date Held By Production (HBP) HBP Date RoyaltyRate 1.75% - 3.5% Most Recent Action ROYALTY RATE -1 Most Recent Action Date 1/12/2009 Location Information Geothermal Resource Area Meridian 26 State(s) Utah Township 0150S Range 0120W Section 5 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=UTU-086775&oldid=665773" Category: BLM Geothermal Case What links here Related changes Special pages Printable version Permanent link Browse properties

326

NVN-077272 | Open Energy Information  

Open Energy Info (EERE)

272 272 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-077272 Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LSE_COMP_PRE_2005 Total Acreage 1274 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 ENEL SALT WELLS LLC Lessee 2 none provided Effective Date 12/1/2003 Expire Date Held By Production (HBP) HELD BY PROD-Actual HBP Date 3/10/2009 RoyaltyRate 10% - 5% - 5% Most Recent Action RLTY RATE -10%- Most Recent Action Date 12/1/2003 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0170N Range 0300E Section 36 Aliquot se Retrieved from "http://en.openei.org/w/index.php?title=NVN-077272&oldid=664730

327

NVN-088430 | Open Energy Information  

Open Energy Info (EERE)

0 0 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-088430 Case Data Survey Type All (section) Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 2960 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 VENTURE PROSPECTS LLC Lessee 2 none provided Effective Date 7/1/2010 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 7/1/2010 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0280N Range 0380E Section 10 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-088430&oldid=666368" Category: BLM Geothermal Case What links here Related changes

328

NVN-076822 | Open Energy Information  

Open Energy Info (EERE)

822 822 Case Data Survey Type Unsurveyed - uprotracted Case Status "Relinguished" is not in the list of possible values (Authorized, Cancelled, Closed, Expired, Pending, Rejected, Relinquished, Withdrawn, Authorized, Cancelled, Closed, Expired, Pending, Rejected, Relinquished, Withdrawn) for this property. Case Type GEO_LSE_NONCOMP_PRE_2005 Total Acreage 2560 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 ORMAT NEVADA INC Lessee 2 none provided Effective Date 9/1/2006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 9/1/2006 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0130N Range 0340E Section 17

329

NVN-083935 | Open Energy Information  

Open Energy Info (EERE)

5 5 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-083935 Case Data Survey Type All (section) Case Status Authorized Case Type GEO_LSE_COMP_POST_2005 Total Acreage 2560 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 ORMAT NEVADA INC Lessee 2 none provided Effective Date 10/1/2007 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 10/1/2007 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0220N Range 0350E Section 11 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-083935&oldid=665780" Category: BLM Geothermal Case What links here Related changes

330

NVN-017283A | Open Energy Information  

Open Energy Info (EERE)

NVN-017283A NVN-017283A Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-017283A Case Data Survey Type Aliquot Part (40 Acres) Case Status Authorized Case Type GEO_LEASE_COMPETITIVE Total Acreage 640 Bid Price/Acre Managing Field Office none provided Surface Manager BUREAU OF LAND MGMT Lessee 1 TGP COYOTE CANYON LLC Lessee 2 none provided Effective Date 11/1/1977 Expire Date Held By Production (HBP) HELD BY LOCATION IN A PRODUCING UNIT HBP Date 6/14/1988 RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 11/1/1977 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0240N Range 0360E Section 22 Aliquot all Retrieved from "http://en.openei.org/w/index.php?title=NVN-017283A&oldid=668997"

331

U.S. Army Fort Carson Photovoltaics Project Lease  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DACA45-1-07-6037 DACA45-1-07-6037 DEPARTMENT OF THE ARMY LEASE FORT CARSON MILITARY INSTALLATION EL PAS0 COUNTY, COLORADO THIS LEASE, made on behalf of the United States, between the SECRETARY OF THE ARMY, hereinafter referred to as the Secretary, and Carson Solar I, LLC., a limited liability company organized and existing under and by virtue of the laws of the State of Delaware, with its principal office at 31 897 Del Obispo, Suite 220, San Juan Capistrano, CA 92675, hereinafter referred to as the Lessee. WITNESSETH: The Secretary, by the authority of Title 10, United States Code, Section 2667, and for the consideration hereinafter set forth, hereby leases to the Lessee the property over, across, in and upon lands of the United States, identified in Exhibits "A" and "B," attached hereto and made a

332

Geothermal energy and the law. I. The Federal Lands Management Program  

DOE Green Energy (OSTI)

A broad range of problems in the legal and institutional environment which hampers the development of the geothermal industry is discussed. The topics include: the development of geothermal energy; pre-leasing procedures--public vs. private assessment; exploratory permits and related strategies; the rate of geothermal leasing-past and future; compensation strategies; lessee qualifications; lands available for leasing; noncompensatory lease terms; ongoing leasehold and production requirements; problems of ''secondary'' geothermal uses; and water law conflicts. (LBS)

Stone, C.D.; McNamara, J.

1975-09-30T23:59:59.000Z

333

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival  

E-Print Network (OSTI)

and BAFF-R signal B cellsurvival? UponBAFFengagement,theBAFF-R signalsmainly through the alternative NF-kB can activate the canonical NF-kB signaling pathway and mature B cells require canonical NF-kB signals) to propose a model in which mature B cell survival is based on an NF-kB-mediated crosstalk between BCR

334

Presence of Terminal EPIYA Phosphorylation Motifs in Helicobacter pylori CagA Contributes to IL-8 Secretion,  

E-Print Network (OSTI)

Ba phosphorylation and confirmed CagA involvement in NF-kB activation. Furthermore, we observed that presence of EPIYA-C functional phosphorylation motifs contributed to NF-kB activation. NF-kB upstream signaling-/- mouse embryonic fibroblasts (MEFs) failed to induce NF-kB activity, unlike the respective control MEFs

335

S:\VM3\RX97\TBL_LIST.WPD  

U.S. Energy Information Administration (EIA) Indexed Site

Million U.S. Households, 1997 Housing Unit Characteristics RSE Column Factor: Total Four Most Populated States RSE Row Factors New York California Texas Florida 0.4 1.1 1.1 1.2 1.7 Total .............................................................. 101.5 6.8 11.5 7.0 5.9 NF Census Region and Division Northeast ..................................................... 19.7 6.8 -- -- -- NF New England ............................................. 5.3 Q -- -- -- NF Middle Atlantic ........................................... 14.4 6.8 -- -- -- NF Midwest ....................................................... 24.1 -- -- -- -- NF East North Central ..................................... 16.9 -- -- -- -- NF West North Central .................................... 7.2 -- -- -- -- NF South ...........................................................

336

Plasmacytoid Dendritic Cells Are Crucial for the Initiation of Inflammation  

E-Print Network (OSTI)

downstream signaling pathways, in which the activation of the transcription factor nuclear factor kB (NF-kB) results in the production of proinflammatory cytokines, whereas the acti- vation of inhibitor of NF-kB (Ik

Gleeson, Joseph G.

337

Molecular Cell STAT3 Activation of miR-21 and miR-181b-1  

E-Print Network (OSTI)

cells via a positive feedback loop involving NF-kB, Lin28, let-7, and IL-6. We identify differentially, respectively, inhibit PTEN and CYLD tumor suppressors, leading to increased NF-kB activity required to maintain

Bulyk, Martha L.

338

Molecular Cell OTULIN Restricts Met1-Linked Ubiquitination  

E-Print Network (OSTI)

of IkBa, leading to nuclear translocation of nuclear factor kB (NF-kB) transcription factors. Together with transcription factors activated by MAP kinases, NF-kB promotes expression of genes that orchestrate

Komander, David

339

10.1101/gad.1936910Access the most recent version at doi: 2010 24: 1533-1545Genes Dev.  

E-Print Network (OSTI)

al. 2009). Studies with NF-kB (Leung et al. 2004) and glucocorticoid receptor (Meijsing et al. 2009- coid receptor and NF-kB affects the regulatory output of the bound complex, suggesting that small

340

Feiqiao Brian Yu 2012.03.16  

E-Print Network (OSTI)

individual cell (5). Another example deals with the study of NF-kB expression in mouse fibroblast cells (5). (B) Contrary to previous studies, NF-kB expression in mouse fibroblast cells occur digitally

Bejerano, Gill

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Molecular mechanisms integrating genetic and calcium activity-dependent neurotransmitter specification  

E-Print Network (OSTI)

adhesion molecule vii NFAT NF-kB NFY Ngn1/2 NMDA NT p-cJuncontrast, activation of the NF-kB transcription factor by Ca

Kurtz, Lisa Miriam

2010-01-01T23:59:59.000Z

342

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

of",6,5,"Aliant Energy Corp.","NF",1,,,30,30 8245,"Hastings City of",6,6,"Mid America Energy Co.","NF",14,,,561,561 8245,"Hastings City of",6,7,"Manitoba Hydro...

343

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

Energy Trading","NF",270,,,15700,15700 9130,"Hutchinson Utilities Comm",6,6,"Manitoba Hydro Power","NF",299,,,4535,4535 9130,"Hutchinson Utilities Comm",6,7,"MidAmerica...

344

Dynamic Chromatin Localization of Sirt6 Shapes Stress-and Aging-Related Transcriptional Networks  

E-Print Network (OSTI)

control. Sirt6 can interact with the stress-responsive transcription factor NF-kB and regulate some NF-kB upon stress-signaling. The majority of genes bound by NF-kB subunit RelA recruit Sirt6, and dynamic of NF-kB signaling in stress response and aging. Citation: Kawahara TLA, Rapicavoli NA, Wu AR, Qu K

Quake, Stephen R.

345

A new indicator for breast cancer relapse identified http://www.eurekalert.org/pub_releases/2012-06/idm-ani061912.php[19/06/2012 16:38:11  

E-Print Network (OSTI)

the signalling of a protein complex called NF-kB, which is related to tumour progression. The activation of NF-kB, although the NF-kB complex is an essential requirement for it to remain active chronically-3-3 sigma and/or the activation of NF-kB in tumour cells as a factor in prognosis and diagnosis, as well

Foissac, Sylvain

346

A New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IkBa  

E-Print Network (OSTI)

factors, col- lectively referred to as nuclear factor-kappa B (NF-kB).[4] In its resting state, NF-kB- flammatory stimuli induce phosphorylation of IkB leading to dissociation of NF-kB from its inhibitors. Once separated from IkB, NF-kB translocates into the nucleus, binds to the target DNA, and initiates gene

Theodorakis, Emmanuel

347

Molecular Cell Crystal Structures of the TRAF2: cIAP2  

E-Print Network (OSTI)

. They are crit- ical for canonical and noncanonical NF-kB signaling pathways. Here, we report the crystal-associated factors (TRAFs) in NF-kB and MAP kinase activation pathways in the signaling of multiple receptor families and the noncanon- ical NF-kB signaling pathways. In the noncanonical NF-kB signaling pathway, TRAF2 and cIAP1

Wu, Hao

348

Molecular discrimination of structurally equivalent Lys63-linked and linear polyubiquitin chains  

E-Print Network (OSTI)

: ubiquitin linkage; deubiquitinase; ubiquitin binding domain; NF-kB signalling; TAK1/IKK/NEMO/NF-kB EMBO (inhibitor of kB kinase) pathway to nuclear factor-kappaB (NF-kB; Adhikari et al, 2007). TAK1 has been shown leads to the activation of IKK by TAK1 and subsequent NF-kB signalling (Adhikari et al, 2007

Komander, David

349

letters to nature 90 NATURE |VOL 406 |6 JULY 2000 |www.nature.com  

E-Print Network (OSTI)

that GSK-3b function is required for the NF-kB-mediated anti-apoptotic response to TNF-a. Our data also . Immunoblotting was carried out with I-kB-a (polyclonal, New England Biolabs), p65 NF-kB (polyclonal, Santa Cruz of either NF-kB-speci®c oligonu- cleotide probe containing two tandem NF-kB-binding sites (59

Davis, Trisha N.

350

To explore further the anti-inflammatory mech-anisms of PGRN and Atsttrin, we investigated  

E-Print Network (OSTI)

the role of PGRN and Atsttrin in the TNFa- induced activation of IKK (IkB kinase)­IkB­ NF-kB (nuclear). Treatment of BMDMs with rhPGRN or Atsttrin impaired TNFa-induced NF-kB nu- clear translocation, NF-kB binding to the IkBa promoter, and activation of gene expression by NF-kB (Fig. 6, C to F) (33). rh

351

DOI: 10.1126/science.1200840 , 484 (2011);332Science  

E-Print Network (OSTI)

activation of IKK (IkB kinase)­IkB­ NF-kB (nuclear factor kB) signaling. rhPGRN and Atsttrin blocked TNFa-induced NF-kB nu- clear translocation, NF-kB binding to the IkBa promoter, and activation of gene expression by NF-kB (Fig. 6, C to F) (33). rhPGRN and Atsttrin also inhibited the TNFa-induced phosphoryla- tion

Gleeson, Joseph G.

352

A novel derivative of decursin, CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K  

E-Print Network (OSTI)

and modulates PI3K and NF-kB activities in HT1080 cells Seung-Hee Lee*, Jee Hyun Lee{ , Eun-Ju Kim*, WonB), phosphorylation of p65 subunit of NF-kB (nuclear factor-kB) and nuclear translocation of NF-kB, which are required. Keywords: cytokine; inflammation; invasion; NF-kB; signal transduction 1. Introduction Decursin

Lee, Won-Ha

353

A chicken c-Rel-estrogen receptor chimeric protein shows conditional nuclear localization, DNA binding, transformation and transcriptional  

E-Print Network (OSTI)

and dierentiation will potentially dier depend- ing on the level of expression. Keywords: c-Rel; NF-kB, Gerondakis et al., 1996). Structurally, c-Rel belongs to a larger family of transcription factors, the Rel/NF-kB family, which also includes RelA, RelB, NF-kB1, NF-kB2, Dorsal, Dif, and Relish. All members

Â?urovec, Michal

354

Joel L.Pomerantz1 , Elissa M.Denny and  

E-Print Network (OSTI)

@caltech.edu NF-kB is a critical target of signaling downstream of the T cell receptor (TCR) complex, but how TCR sig- naling activates NF-kB is poorly understood. We have developed an expression cloning strategy that can identify catalytic and noncatalytic molecules that par- ticipate in different pathways of NF-kB

Baltimore, David

355

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative  

E-Print Network (OSTI)

Regulation of Noncanonical NF-kB Signaling Irving C. Allen,1 Justin E. Wilson,1 Monika Schneider,2 John D of NLR proteins, including NLRP12, inhibits the transcription factor NF-kB, although physiologic and disease-rele- vant evidence is largely missing. Dysregulated NF-kB activity is associated with colonic

356

Tea Pigments Inhibit the Production of Type 1 (TH1) and Type 2 (TH2) Helper T Cell Cytokines  

E-Print Network (OSTI)

been linked to their capacity to inhibit the activation of nuclear factor-kB (NF-kB), a transcription. The current study examines the requirement for NF-kB in the immunosuppressive effects mediated by tea require NF-kB for gene expression, such as interleukin-2 (IL-2) and interferon gamma (IFN g

Brand, Paul H.

357

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2  

E-Print Network (OSTI)

-apoptotic properties of PB1-F2. Using a NF-kB luciferase adenoviral vector, we were able to quantify in vivo the implication of NF-kB in the inflammation mediated by the influenza virus infection; we found that PB1-F2 expression intensifies the NF-kB activity. Finally, we quantified the neutrophil recruitment within

Paris-Sud XI, Université de

358

Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene  

E-Print Network (OSTI)

. IKK3 acti- vates the nuclear factor-kappaB (NF-kB) path- way in both cell lines and breast cancers. These observations suggest a mechanism for NF-kB activation in breast cancer, implicate the NF-kB pathway

359

Melatonin Alters Age-Related Changes in Transcription Factors and Kinase Activation  

E-Print Network (OSTI)

not to alter the extent of NF-kB or AP-1 activation [14]. X-in the spleen, dietary a NF-kB activity (densitometic units)YC YM OC OM b NF-kB activity (densitometic units) Results

Bondy, Stephen Bondy C

2010-01-01T23:59:59.000Z

360

Molecular Cell, Volume 37 Supplemental Information  

E-Print Network (OSTI)

a gradual increase in NF-kB p65 nuclear concentration. (A) Wild-type HCT 116 cells were stimulated with increasing doses of TNF for 20 minutes. The nuclear translocation of NF-kB was assessed by immunofluorescence that increasing TNF doses induce uniformly increasing nuclear localization of NF-kB in the cell population. (C) We

Bulyk, Martha L.

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

sortium for sharing analysis results; C. Allen and H. McClure of the Yerkes Primate Center, Atlanta, and  

E-Print Network (OSTI)

when citing this paper. Achieving Stability of Lipopolysaccharide-Induced NF-kB Activation Markus W of the transcription factor NF-kB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis-like receptor 4 (TLR4) causes activation of NF-kB that requires two down- stream pathways, each of which when

Baltimore, David

362

Ah receptor represses acute-phase response gene expression without binding to its cognate response  

E-Print Network (OSTI)

Repression of the nuclear factor-kB (NF-kB) pathway has been extensively researched because of its pivotal NF-kB regulated-gene expression, especially acute-phase genes, such as serum amyloid A (Saa). Using of transcription factors, such as nuclear factor-kB (NF-kB), signal transducer and activator of transcription-3

Perdew, Gary

363

12. McDonald, J. C. & Whitesides, G. M. Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. Accounts Chem. Res. 35, 491499 (2002).  

E-Print Network (OSTI)

macrophage NF-kB activation and contributes to the resolution of inflammation Toby Lawrence1 *, Magali Bebien and IKKb, and controls the activation of NF-kB transcription factors, which play a pivotal role in inflammation2 . Ample evidence indicates that IKKb mediates NF-kB activation in response to pro-inflamma- tory

Nizet, Victor

364

caspase-8 became enzymatically active after TCR stimulation (Fig. 3H and fig. S8G).  

E-Print Network (OSTI)

caspase-8 became enzymatically active after TCR stimulation (Fig. 3H and fig. S8G). Hence, NF-kB activation by antigen receptors requires enzyme activity of full-length caspase- 8. In the NF-kB-receptor signaling and as a selective signal transducer for NF-kB during the early genetic response to an antigen

Kharasch, Evan

365

Cell cycle and DNA damage response regulation by Spy1, and the intersection of FGFR and NFkappaB pathways  

E-Print Network (OSTI)

Bio-Rad). Quantification of NF-kB binding to the probe wasBio-Rad). The average NF-kB binding from three independentBio-Rad). Quantification of NF-kB binding to the probe was

McAndrew, Christopher William

2010-01-01T23:59:59.000Z

366

Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis.  

E-Print Network (OSTI)

expression of AFP, hsp-90 and NF-kB. Acknowledgements This90; miRNA, microRNA; NF-kB, nuclear factor-k B; siRNA, short90) and nuclear factor-kB (NF-kB). Overexpression of miRNA-

Wu, Jian; Zern, M A

2010-01-01T23:59:59.000Z

367

Control of Stochastic Gene Expression by Host Factors at the HIV Promoter  

E-Print Network (OSTI)

promoter contains cis- acting Sp1 and NF-kB elements that regulate gene expression via the recruitment lentivirus variants with mutations introduced in the Sp1 and NF-kB elements, we employed flow cytometry, m and reduction in the regulation of histone acetylation and deacetylation. Furthermore, the NF-kB sites exhibit

Schaffer, David V.

368

MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in  

E-Print Network (OSTI)

MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in Tax-induced NF-kB activation of the NF-kB pathway, a property that is required for HTLV-1-induced T cell immortalization. Tax activates the NF-kB pathway by acting both at cytoplasmic and nuclear levels. In the cytoplasm, Tax binds

Paris-Sud XI, Université de

369

Molecular Cell The Structure of the CYLD USP Domain  

E-Print Network (OSTI)

The tumor suppressor CYLD antagonizes NF-kB and JNK signaling by disassembly of Lys63-linked ubiqui- tin al., 2000). CYLD negatively regulates activation of the cell-survival effec- tor NF-kB, a finding for stimulation of NF-kB and JNK in the innate and adaptive immune response (Jin et al., 2007; Zhang et al., 2006

Komander, David

370

The intersection of NFkappaB and fibroblast growth factor receptor signaling pathways  

E-Print Network (OSTI)

Bio-Rad). Quantification of NF-kB binding to the probe wasBio- Rad). The average NF-kB binding from three independentBio-Rad). Quantification of NF-kB binding to the probe was

Drafahl, Kristine A.

2009-01-01T23:59:59.000Z

371

Blood proteolytic activity elevation and plasma protein degradation in spontaneously hypertensive rat models  

E-Print Network (OSTI)

G-protein alpha s, H-Ras, NF-kB, pard6, PI3K cat class IA,G-protein alpha-s, H-Ras, NF-kB, Pi3k cat class IA, PKA-cat,Beta-catenin, MDM2, MMP-2, NF-kb, PIAS2, SUMO- 1, XPA, p21

Chow, Jason C

2011-01-01T23:59:59.000Z

372

Molecular Cell Recruitment of the Linear Ubiquitin Chain Assembly  

E-Print Network (OSTI)

, and is required for efficient TNF-induced activation of NF-kB and JNK, resulting in apoptosis inhibition. Finally-activated protein (MAP) kinase cascades and NF-kB activation (Wajant et al., 2003). Ligand-induced trimerization., 2008). TRAF2 and RIP1 play important roles in the activation of JNK and NF-kB, respectively (Devin et

Komander, David

373

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing  

E-Print Network (OSTI)

-linked (also known as linear) Ub chains that regulate nuclear factor kB (NF-kB) signaling. Deubi by reducing kcat 240-fold. OTULIN overexpression or knockdown affects NF-kB re- sponses to LUBAC, TNFa has roles in NF-kB activation (Haas et al., 2009; Toku- naga and Iwai, 2012; Tokunaga et al., 2009

Komander, David

374

Metabolic disorders in heart diseases with an inflammatory background  

E-Print Network (OSTI)

2010 This editorial refers to `The p65 subunit of NF-kB binds to PGC-1a, linking inflammation. Introduction Cardiac hypertrophy and heart failure are associated with nuclear factor-kB (NF-kB) activation major pathways. 2. Link between NFkB and PGC-1a pathways The general term NF-kB traditionally refers

Paris-Sud XI, Université de

375

Gene Regulation in M Cell Lineages: In Vitro and In Vivo  

E-Print Network (OSTI)

LTbR agonist (Fig 2-1C). The NF-kB gene relB (Relb) has alsoof relB is regulated by NF-kB activation, and the LT?R andreceptors all signal through NF-kB activation, this finding

Wang, Jing

2011-01-01T23:59:59.000Z

376

Specific Recognition of Linear Ubiquitin Chains by NEMO  

E-Print Network (OSTI)

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-kB Activation Simin.03.007 SUMMARY Activation of nuclear factor-kB (NF-kB), a key medi- ator of inducible transcription in immunity, requires binding of NF-kB essential modulator (NEMO) to ubiquitinated substrates. Here, we report

Komander, David

377

Cancer Cell A Transcriptional Signature and Common  

E-Print Network (OSTI)

. As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kB, leading, 2006; De Marzo et al., 2007; Naugler and Karin, 2008; Pierce et al., 2009). Constitutively active NF-kB, and mouse models provide evidence for a causative role of NF-kB in malignant conversion and progression

Bulyk, Martha L.

378

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune  

E-Print Network (OSTI)

. pneumophila lacking the Dot/Icm system is recognized by Toll-like receptors (TLRs), leading to a canonical NF-kB, thereby preventing synthesis of IkB, an inhibitor of the NF-kB transcription factor. Thus, macrophages infected with wildtype L. pneumophila exhibited prolonged activation of NF-kB, which was associated

Vance,. Russell

379

Cloning and characterization of Dorsal homologues in the hemipteran Rhodnius prolixusimb_909 681..690  

E-Print Network (OSTI)

by transcription factors of the Rel/ Nuclear Factor kappa B (Rel/NF-kB) family. We have cloned and characterized is that of Nuclear Factor kappa B (NF-kB), named after the transcrip- tional activator of the immunoglobulin kappa light chain in human B-lymphocytes (Sen & Baltimore, 1986). A func- tional NF-kB transcription factor

Lowenberger, Carl

380

Received 9 Nov 2012 | Accepted 28 Jan 2013 | Published 5 Mar 2013 Regulation of A20 and other OTU  

E-Print Network (OSTI)

such as activation of protein kinase cascades during NF-kB (nuclear factor-kB) activation2,3. Ub modifications described to regulate the transcription factor NF-kB (ref. 6), activation of which depends on an intricate in hyperinflammatory phenotypes consistent with deregulated NF-kB signalling. Mechanistically, A20 establishes

Komander, David

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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381

Molecular Cell Noncooperative Interactions between Transcription  

E-Print Network (OSTI)

the definition of anatomical boundaries during development. Here we show that NF-kB, a TF controlling noncoop- eratively. We observed that increasing concentra- tions of NF-kB are translated into gradual by combining quantitative measurements and a minimal physical model of an NF-kB-dependent promoter. We

Bulyk, Martha L.

382

Functional dissection of homeodomain transcription factors HoxA9 and Meis1 in myeloid leukemia : their epigenetic regulation and their downstream targets  

E-Print Network (OSTI)

protein 3. A20. Neg reg Toll/NF-kB signaling Socs3 Cytokine-2, C polypeptide. Adhesion, NF-kB activation Hsd11b1Peli1 Pellino1. Required for NF-kB activation through IL1R

Wang, Gang

2006-01-01T23:59:59.000Z

383

Second SICSA Workshop on Biological Networks: Theory and Applications  

E-Print Network (OSTI)

stimulation, oscillatory MAPK, p53, NF-kB network with optional UV modulation Oscillations have been factor kappa-light-chain-enhancer of activated B cell (NF-kB) is conducted. A candidate for a tumor necrosis factor- (TNF-) controlled stimulation, oscillating MAPK, p53, NF-kB network with optional

Edinburgh, University of

384

ARTICLE doi:10.1038/nature09853 Crystal structure of inhibitorof kB kinase b  

E-Print Network (OSTI)

a similar trimodular architecture and function. Nuclear factor kB (NF-kB) transcription factors are master regulators of inflammatory, immune and apoptotic responses1,2 . In the canonical pathway, NF-kB dimers. When cells are stimulated by NF-kB inducers, IkB proteins are phosphorylated by the Ser

Wu, Hao

385

Table HC1-12a. Housing Unit Characteristics by West Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

2a. Housing Unit Characteristics by West Census Region, 2a. Housing Unit Characteristics by West Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. West Census Region RSE Row Factors Total Census Division Mountain Pacific 0.5 1.0 1.7 1.1 Total .............................................................. 107.0 23.3 6.7 16.6 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- NF New England ............................................. 5.4 -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- NF Midwest ....................................................... 24.5 -- -- -- NF East North Central ..................................... 17.1 -- -- -- NF West North Central ....................................

386

Decay constants of B and D mesons from improved relativistic lattice QCD with two flavours of sea quarks  

E-Print Network (OSTI)

We present a calculation of the B and D meson decay constants in lattice QCD with two (Nf=2) flavours of light dynamical quarks, using an O(a)-improved Wilson action for both light and heavy quarks and a renormalization-group improved gauge action. Simulations are made at three values of lattice spacing a=0.22, 0.16, 0.11 fm and four values of sea quark mass in the range m_PS/m_V \\~= 0.8-0.6. Our estimate for the continuum values of the decay constants are fBd = 208(10)(11) MeV, fBs = 250(10)(13)(^{+8}_{-0}) MeV, fDd = 225(14)(14) MeV, fDs = 267(13)(17)(^{+10}_{-0}) MeV for Nf=2 where the statistical and systematic errors are separately listed, and the third error for fBs and fDs show uncertainty of determination of strange quark mass. We also carry out a set of quenched simulations using the same action to make a direct examination of sea quark effects. Taking the ratio of results for Nf=2 and Nf=0, we obtain fb^{Nf=2}/fb^{Nf=0} = 1.11(6), fbs^{Nf=2}/fbs^{Nf=0} = 1.14(5), fd^{Nf=2}/\\fd^{Nf=0} = 1.03(6), fds^...

Khan, A A; Burkhalter, R; Ejiri, S; Fukugita, M; Hashimoto, S; Ishizuka, N; Iwasaki, Y; Kanaya, K; Kaneko, T; Kuramashi, Y; Manke, T; Nagai, K; Okawa, M; Shanahan, H P; Ukawa, A; Yoshié, T

2001-01-01T23:59:59.000Z

387

6. Chan, F. K., Siegel, M. R. & Lenardo, J. M. Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity 13, 419422 (2000).  

E-Print Network (OSTI)

, T., Green, D. R. & Verma, I. M. Suppression of TNF-a-induced apoptosis by NF-kB. Science 274, 787 functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death. Cell 87., Dixit, V. M. & Goeddel, D. V. TRAF2-mediated activation of NF-kB by TNF receptor 2 and CD40. Science 269

Hutchinson, John

388

of May 16, 2013. This information is current as  

E-Print Network (OSTI)

-binding proteins TGF-b­activated kinase 1 (TAK1)­binding protein (TAB)2 and TAB3 are implicated in NF-kB signaling via TAK1 activation. However, TAB2 alone is dispensable for NF-kB activation in embryonic fibroblasts, but not NF-kB, in response to TLR and CD40 stimulation in B cells. Surprisingly, TAB2 and TAB3

389

RELB, A NEW PARTNER OF ARYL HYDROCARBON RECEPTOR-MEDIATED TRANSCRIPTION  

E-Print Network (OSTI)

-00268250,version1-31Mar2008 #12;3 INTRODUCTION The NF-kB/Rel transcription factors play critical roles, and apoptosis. Transcriptionally active NF-kB dimers are formed by combinatorial association of five subunits: p50, RelA (p65), p52, c-Rel, and RelB (1). The classic inducible NF-kB heterodimer consists of the p50

Paris-Sud XI, Université de

390

A jB sequence code for pathway-specific innate immune responses  

E-Print Network (OSTI)

of the NF-kB family of transcription factors, for example, vertebrate p50 and p65 (Ghosh et al, 1998; Karin and Ben-Neriah, 2000; Brennan and Anderson, 2004; Xiao and Ghosh, 2005). In the absence of a stimulus, NF-kB that allow NF-kB factors to enter the nucleus and direct expression of antimicrobial agents and secondary

391

(161), ra11. [DOI: 10.1126/scisignal.2001501]4Science Signaling Benedict, Gourisankar Ghosh and Alexander Hoffmann (22 February 2011)  

E-Print Network (OSTI)

of Interferon Response Elements by NF-kB p50 Christine S. Cheng,1,2,3 Kristyn E. Feldman,1,2 James Lee,1 programs. Members of the nuclear factor kB (NF-kB) and interferon (IFN) regulatory factor (IRF-down and bottom-up systems biology approaches, we have identified the NF-kB p50 homodimer as a regulator of IRF

Hasty, Jeff

392

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3  

E-Print Network (OSTI)

function and NF-kB signaling Di Sha, Lih-Shen ChinÃ? and Lian LiÃ? Department of Pharmacology and CenterB kinase/nuclear factor kB (NF-kB) pathway. Furthermore, the ability of PINK1 to promote parkin-mediated ubiquitin signaling and implicate the deregulation of the PINK1/parkin/NF-kB neuroprotective signaling

Li, Lian

393

www.cell-research.com | Cell Research Guoliang Qing et al.  

E-Print Network (OSTI)

B, inhibitor of NF-kB; IKK, IkB kinase Received 28 September 2006; revised 9 October 2006; accepted 10 October that the IkB kinase (IKK), an essential activator of NF-kB, is selectively degraded by autophagy when Hsp90 and establish a molecular link among Hsp90, NF-kB and autophagy Cell Research (2006) 16:895-901. doi:10.1038/sj

Cai, Long

394

letters to nature NATURE |VOL 414 |13 DECEMBER 2001 |www.nature.com 759  

E-Print Network (OSTI)

±1318 (1999). 2. Khush, R. S., Leulier, F. & Lemaitre, B. Drosophila immunity: two paths to NF-kB. Trends. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kB receptor-mediated Drosophila immune response requires Dif, an NF-kB factor. Genes Dev. 13, 792±797 (1999

Schnaufer, Achim

395

Molecular Cell Hydrogen Sulfide-Linked Sulfhydration  

E-Print Network (OSTI)

Molecular Cell Article Hydrogen Sulfide-Linked Sulfhydration of NF-kB Mediates Its Antiapoptotic@jhmi.edu DOI 10.1016/j.molcel.2011.10.021 SUMMARY Nuclear factor kB (NF-kB) is an antiapoptotic tran- scription factor. We show that the antiapoptotic actions of NF-kB are mediated by hydrogen sulfide (H2S

Dong, Xinzhong

396

POSTER PRESENTATION Open Access HIV triggers immunoregulatory dendritic cells  

E-Print Network (OSTI)

T cells through the non-canonical NF-kB pathway O Manches1* , MV Fernandez1 , J Plumas2 , L Chaperot2 , N activation of the non-canonical NF-kB pathway in pDC, and is essential for IDO induction. TLR7 triggering-dependent fashion, allowing cDC to induce Treg from naïve CD4+ T cells. Conclusion The non-canonical NF-kB pathway

Paris-Sud XI, Université de

397

Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a  

E-Print Network (OSTI)

of a Gene Cluster That Targets NF-kB Angela Garding1,2. , Nupur Bhattacharya1.¤a , Rainer Claus3¤b , Melanie NF-kB activity, which we could show after overexpression, siRNA­mediated knockdown, and dominant/16 family of genes at 13q14.3 as the strongest inducers of NF-kB activity. In summary, the tumor suppressor

Rippe, Karsten

398

Molecular Cell Structural Basis for Recognition  

E-Print Network (OSTI)

.01.012 SUMMARY NEMO is the regulatory subunit of the IkB kinase (IKK) in NF-kB activation, and its CC2-LZ region. INTRODUCTION NF-kB proteins are evolutionarily conserved master regulators of immune and inflammatory responses/Thr-specific IkB kinase (IKK) signalosome is at the bottleneck for NF-kB activation because activated IKK

Wu, Hao

399

(290), ra75. [DOI: 10.1126/scisignal.2004097]6Science Signaling Linda C. Hsieh-Wilson and David Baltimore (27 August 2013)  

E-Print Network (OSTI)

Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation Parameswaran Ramakrishnan,1 * Peter M. Clark factor nuclear factor kB (NF-kB) rapidly reprograms gene expression in response to various stimuli stress. We report that the NF-kB subunit c-Rel is modified and acti- vated by O-GlcNAcylation. We

Gleeson, Joseph G.

400

Lattice Study of the Conformal Window in QCD-like Theories  

E-Print Network (OSTI)

Using lattice simulations, we study the extent of the conformal window for an $\\text{SU}(3)$ gauge theory with $N_f$ Dirac fermions in the fundamental representation. We present evidence that the infrared behavior is conformal for $12 \\leq N_f \\leq 16$, governed by an infrared fixed point, while confinement and chiral symmetry breaking are present for $N_f \\leq 8$.

Thomas Appelquist; George T. Fleming; Ethan T. Neil

2007-12-04T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Table HC1-11a. Housing Unit Characteristics by South Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

1a. Housing Unit Characteristics by South Census Region, 1a. Housing Unit Characteristics by South Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. South Census Region RSE Row Factors Total Census Division South Atlantic East South Central West South Central 0.5 0.9 1.2 1.4 1.4 Total .............................................................. 107.0 38.9 20.3 6.8 11.8 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- -- NF New England ............................................. 5.4 -- -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- -- NF Midwest ....................................................... 24.5 -- -- -- -- NF East North Central .....................................

402

Single-qubit-gate error below 10 in a trapped ion  

Science Conference Proceedings (OSTI)

... computers depends on the ability to accurately control sensitive super- position amplitudes by ... near 1.25 GHz, coupled with a 4-nF capacitor to one ...

2011-10-28T23:59:59.000Z

403

THE LONG TERM CALIBRATION STABILITY OF CRITICAL ...  

Science Conference Proceedings (OSTI)

... through nf flow tubes with circular cross section, ... Real Gas Eflects in Critical Flow through Nozzles ... of the Effects of Heat Transfer and Compressible ...

2012-10-29T23:59:59.000Z

404

Mosaic neurofibromatosis type 1  

E-Print Network (OSTI)

with neurofibromatosis type 1 (NF1) with microdeletionsM, Huson S. Mosaic (segmental) neurofibromatosis type 1and type 2: no longer neurofibromatosis type 5. Am J Med

Liang, Christine; Schaffer, Julie V

2008-01-01T23:59:59.000Z

405

Construction of Risk-Averse Enhanced Index Funds  

E-Print Network (OSTI)

?George Washington University, Washington, DC, 20052, mlejeune@gwu.edu. The author is partially supported by the Grant #. W911NF-09-1-0497 from the ...

406

Table 2. Fuel Oil Consumption and Expenditures in U.S. Households ...  

U.S. Energy Information Administration (EIA)

1 A small amount of fuel oil used for appliances is included in "Fuel Oil" under "All Uses." NF = No applicable RSE row factor.

407

BMC Cancer BioMed Central  

E-Print Network (OSTI)

Research article Genistein inhibits radiation-induced activation of NF-?B in prostate cancer cells promoting apoptosis and G2 /M cell cycle arrest

Julian J Raffoul; Yu Wang; Omer Kucuk; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman

2006-01-01T23:59:59.000Z

408

Stuart R Hudson | Princeton Plasma Physics Lab  

NLE Websites -- All DOE Office Websites (Extended Search)

approach for optimizing currents in H-1NF stellarator in operation in the Plasma Research Laboratory at the ANU to control vacuum magnetic islands was introduced. After...

409

Slide 1  

National Nuclear Security Administration (NNSA)

chemistry (AC) and materials characterization (MC) mission work CMR Chemistry and Metallurgy Research CMRR-NF CMR Replacement - Nuclear Facility RLUOB Radiological...

410

Chemistry and Metallurgy Research Replacement - Nuclear Facility...  

National Nuclear Security Administration (NNSA)

Chemistry and Metallurgy Research Replacement - Nuclear Facility (CMRR-NF SEIS) | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing...

411

Die Jontophorese der mit medikamentö  

Science Conference Proceedings (OSTI)

Flora, 131. N.F. 31, 87--112, 1936. Die bevorzugte Aufnahme saurer Farbstoffe bei hoher Wasserstoffionen- konzentration der die Zellen yon Asperffillus niger ...

412

Dynamic Modeling of Behavior Change H. T. Banks, Keri L. Rehm, Karyn L. Sutton  

E-Print Network (OSTI)

chacun des noeuds des deux documents : sds1(r) = snf 1(r) = pr tree Ã? p nf 1 tree + pr paper Ã? pnf 1

413

Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes  

E-Print Network (OSTI)

The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important ...

Lovell, Nathan Gary

2010-01-01T23:59:59.000Z

414

Numerical Investigation of Interaction Between Hydraulic Fractures and Natural Fractures  

E-Print Network (OSTI)

Hydraulic fracturing of a naturally-fractured reservoir is a challenge for industry, as fractures can have complex growth patterns when propagating in systems of natural fractures in the reservoir. Fracture propagation near a natural fracture (NF) considering interaction between a hydraulic fracture (HF) and a pre-existing NF, has been investigated comprehensively using a two dimensional Displacement Discontinuity Method (DDM) Model in this thesis. The rock is first considered as an elastic impermeable medium (with no leakoff), and then the effects of pore pressure change as a result of leakoff of fracturing fluid are considered. A uniform pressure fluid model and a Newtonian fluid flow model are used to calculate the fluid flow, fluid pressure and width distribution along the fracture. Joint elements are implemented to describe different NF contact modes (stick, slip, and open mode). The structural criterion is used for predicting the direction and mode of fracture propagation. The numerical model was used to first examine the mechanical response of the NF to predict potential reactivation of the NF and the resultant probable location for fracture re-initiation. Results demonstrate that: 1) Before the HF reaches a NF, the possibility of fracture re-initiation across the NF and with an offset is enhanced when the NF has weaker interfaces; 2) During the stage of fluid infiltration along the NF, a maximum tensile stress peak can be generated at the end of the opening zone along the NF ahead of the fluid front; 3) Poroelastic effects, arising from fluid diffusion into the rock deformation can induce closure and compressive stress at the center of the NF ahead of the HF tip before HF arrival. Upon coalescence when fluid flows along the NF, the poroelastic effects tend to reduce the value of the HF aperture and this decreases the tension peak and the possibility of fracture re-initiation with time. Next, HF trajectories near a NF were examined prior to coalesce with the NF using different joint, rock and fluid properties. Our analysis shows that: 1) Hydraulic fracture trajectories near a NF may bend and deviate from the direction of the maximum horizontal stress when using a joint model that includes initial joint deformation; 2) Hydraulic fractures propagating with higher injection rate or fracturing fluid of higher viscosity propagate longer distance when turning to the direction of maximum horizontal stress; 3) Fracture trajectories are less dependent on injection rate or fluid viscosity when using a joint model that includes initial joint deformation; whereas, they are more dominated by injection rate and fluid viscosity when using a joint model that excludes initial joint deformation.

Xue, Wenxu

2010-12-01T23:59:59.000Z

415

Data:71b1efad-29f2-473a-a71e-f43499842f13 | Open Energy Information  

Open Energy Info (EERE)

efad-29f2-473a-a71e-f43499842f13 efad-29f2-473a-a71e-f43499842f13 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: PUD No 1 of Grays Harbor Cnty Effective date: 2010/02/01 End date if known: Rate name: Yard Lighting Schedule 88 HPS 1000W Sector: Lighting Description: This schedule is applicable to all property owners or long term lessees of property with yard light service. Source or reference: https://www.ghpud.org/index.php?option=com_content&view=article&id=120:yard-lighting&catid=114:rates&Itemid=207 Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW):

416

U.S. Department of Energy Office of Legacy Management National Environmental Policy Act Environmental Checldist  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

28-10 28-10 U.S. Department of Energy Office of Legacy Management National Environmental Policy Act Environmental Checldist Project/Activity: New Verde Mine Investigations, Lease Tract C-G-26, Uranium Leasing Program A. Brief Project/Activity Description Energy Fuels Resources Corporation (EFRC), lessee to the U.S. Department of Energy Office of Legacy Management, proposes to evaluate former mine workings associated with the New Verde Mine on Lease Tract C-G-26 in preparation for potential future mine development. This lease tract is on Calamity Mesa, along the southern flank of the Uncompahgre Plateau in southwestern Mesa County. The mine site would be accessed by workers on a former mine access road and on public roads. A bulkhead, approximately 6 feet (ft) high and 9 ft wide, was constructed of concrete blocks in 1996 to seal the

417

CX-003488: Categorical Exclusion Determination | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

88: Categorical Exclusion Determination 88: Categorical Exclusion Determination CX-003488: Categorical Exclusion Determination New Verde Mine Investigations, Lease Tract C-G-26, Uranium Leasing Program CX(s) Applied: B1.28, B3.1 Date: 08/10/2010 Location(s): Mesa County, Colorado Office(s): Legacy Management Energy Fuels Resources Corporation (EFRC), lessee to the U.S. Department of Energy Office of Legacy Management, proposes to evaluate former mine workings associated with the New Verde Mine on Lease Tract C-G-26 in preparation for potential future mine development. This lease tract is on Calamity Mesa, along the southern flank of the Uncompahgre Plateau in southwestern Mesa County. The mine site would be accessed by workers on a former mine access road and on public roads. DOCUMENT(S) AVAILABLE FOR DOWNLOAD

418

Geothermal Steam Act of 1970 | Open Energy Information  

Open Energy Info (EERE)

Steam Act of 1970 Steam Act of 1970 Jump to: navigation, search To encourage the development of geothermal energy, the United States government passed the Geothermal Steam Act in 1970 allowing the leasing of land containing geothermal resources; however, Congress excluded any lands within the National Park System, U.S. Fish and Wildlife Service lands, and any other lands prohibited from leasing by the Mineral Leasing Act of 1920. The Bureau of Land Management (BLM) administrates the Act, issuing distinct authorizations for the exploration, development, production, and closeout of a geothermal resource. When a lessee first receives a lease, they have ten years to reach a certain level of development with the land; upon demonstrating such development, BLM extends their lease to 40 years, after

419

NASA Enhanced Use Lease  

NLE Websites -- All DOE Office Websites (Extended Search)

KCA-4204 KCA-4204 NASA JOHN F. KENNEDY SPACE CENTER ENHANCED USE LEASE This Enhanced Use Lease (the "Lease") is made as of the date set forth below by the signatories, by and between the NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, an Agency of the United States, John F. Kennedy Space Center, Florida, as the lessor (hereinafter "NASA-KSC"), and Florida Power & Light Company, a corporation organized and existing under the laws of the State of Florida, as the lessee (hereinafter "FPL"). This Lease is made under the authority of section 315 of the National Aeronautics and Space Act of 1958, as amended (42 U.S.C. §2459j) with reference to the following facts: R E C I T A L S A. NASA-KSC is committed to using its real property assets to efficiently

420

NASA Enhanced Use Lease  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

KCA-4204 KCA-4204 NASA JOHN F. KENNEDY SPACE CENTER ENHANCED USE LEASE This Enhanced Use Lease (the "Lease") is made as of the date set forth below by the signatories, by and between the NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, an Agency of the United States, John F. Kennedy Space Center, Florida, as the lessor (hereinafter "NASA-KSC"), and Florida Power & Light Company, a corporation organized and existing under the laws of the State of Florida, as the lessee (hereinafter "FPL"). This Lease is made under the authority of section 315 of the National Aeronautics and Space Act of 1958, as amended (42 U.S.C. §2459j) with reference to the following facts: R E C I T A L S A. NASA-KSC is committed to using its real property assets to efficiently

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

CX-003331: Categorical Exclusion Determination | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1: Categorical Exclusion Determination 1: Categorical Exclusion Determination CX-003331: Categorical Exclusion Determination Reclamation Projects on Slick Rock Lease Tract C-SR-II, Uranium Leasing Program CX(s) Applied: B1.28 Date: 07/30/2010 Location(s): San Miguel County, Colorado Office(s): Legacy Management The U.S. Department of Energy (DOE) Office of Legacy Management (LM) proposes various reclamation activities related to abandoned mines and mine features that constitute a public safety concern. Independent contractors associated with the lessee (Cotter Corporation) and under supervision of uranium leasing program (ULP) personnel would complete the work, and all projects would be completed within approximately 3 weeks. C-SR-II is located in southwestern San Miguel County, Colorado. The total estimated

422

Durango CO EOI  

Office of Legacy Management (LM)

REQUEST FOR EXPRESSION OF INTEREST REQUEST FOR EXPRESSION OF INTEREST Lease to construct Solar Photovoltaic System on Federal land INTRODUCTION The S.M. Stoller Corporation (Stoller), operating as the Office of Legacy Management (LM) Support Contractor for the U. S. Department of Energy (DOE) is requesting an Expression of Interest from prospective Lessees (teams, joint ventures, etc.) that would be interested in leasing government-owned land near Durango, CO to construct a solar photovoltaic (PV) system. DOE created LM in 2003 to manage sites where DOE's mission is complete and to ensure the future protection of human health and the environment. A part of the LM mission is to make excess lands available for beneficial reuse. The Durango, CO site has been approved for reuse and construction of a solar PV system.

423

EA-1944-DEA-AppendixA-2012.pdf  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

ORNI 9, LLC, AND ORMAT NEVADA INC. ORNI 9, LLC, AND ORMAT NEVADA INC. APPLICATIONS FOR PERMIT TO DRILL GEOTHERMAL OBSERVATION WELLS 82-14 AND 55-14 AND GEOTHERMAL PRODUCTION WELL 15-12 AND POSSIBLE FUTURE GEOTHERMAL WELLS LOCATED IN SECTIONS 12, and 14, T22N, R26E, MDB&M BLM Geothermal Leases NVN-065558 and NVN-065561 BLM Environmental Assessment No. NV-020-05-07 CONDITIONS OF APPROVAL 1. This approval is contingent upon the lessee/operator being in receipt of and in compliance with all appropriate federal, state, and local permits. 2. When cultural or paleontological resources, including but not limited to historic ruins, prehistoric artifacts and fossils, are discovered in the performance of the permit, the resources shall be left intact and immediately brought to the attention of the BLM authorized officer.

424

U.S. Department of Energy Office of Legacy Management National Environmental Policy Act Environmental Checklist  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

25-10 25-10 U.S. Department of Energy Office of Legacy Management National Environmental Policy Act Environmental Checklist Project/Activity: Reclamation Projects on Slick Rock Lease Tract C-SR-II, Uranium Leasing Program A. BriefProject/Activity Description The U.S. Department of Energy (DOE) Office of Legacy Management (LM) proposes various reclamation activities related to abandoned mines and mine features that constitute a public safety concern. Independent contractors associated with the lessee (Cotter Corporation) and under supervision of uranium leasing program (ULP) personnel would complete the work, and all projects would be completed within approximately 3 weeks. C-SR-ll is located in southwestern San Miguel County, Colorado. The total estimated surface disturbance would cover 3 acres.

425

U.S. Department of Energy Office of Legacy Management National Environmental Policy Act Environmental Checklist  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

26-10 U.S. Department of Energy Office of Legacy Management National Environmental Policy Act Environmental Checklist Project/Activity: Reclamation Projects on Wedding Bell Mountain Lease Tract C-WM-17, Uranium Leasing Program A. BriefProject/Activity Description The U.S. Department of Energy (DOE) Office of Legacy Management (LM) proposes several minor reclamation activities related to abandoned mines and mine features that pose a public safety concern. In 2007, LM inherited abandoned mines as a result of re-aligning lease tract boundaries.1pdependent contractors associated with the lessee (Golden Eagle Uranium) and under the supervision of uranium leasing program personnel would complete the work, and all projects would be completed within approximately 2 days. The Wedding Bell Mountain Lease

426

Oil and Gas Wells: Regulatory Provisions (Kansas) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Oil and Gas Wells: Regulatory Provisions (Kansas) Oil and Gas Wells: Regulatory Provisions (Kansas) Oil and Gas Wells: Regulatory Provisions (Kansas) < Back Eligibility Commercial Fuel Distributor Investor-Owned Utility Municipal/Public Utility Rural Electric Cooperative Utility Program Info State Kansas Program Type Environmental Regulations Provider Health and Environment It shall be unlawful for any person, firm or corporation having possession or control of any natural gas well, oil well or coalbed natural gas well, whether as a contractor, owner, lessee, agent or manager, to use or permit the use of gas by direct well pressure. Any person or persons, firm, company or corporation violating any of the provisions of this act shall be deemed guilty of a misdemeanor, and upon conviction shall be fined in any

427

Tax Deductions for Commercial Buildings  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Tax Deductions for Commercial Buildings Tax Deductions for Commercial Buildings Promoting Energy Savings for Businesses S igned by President Bush on August 8, 2005, the Energy Policy Act (EPACT) lays the foundation for the new Federal tax incentives for consumers and businesses that pursue energy efficiency and the use of renewable energy. For updated information about the tax incentives, see www.energy.gov. This web- site also describes other EPACT provisions of interest to businesses, including incen- tives for distributed generation and hybrid fuel fleet vehicles. Tax Deductions for Commercial Building Owners Commercial building owners and lessees who purchase and install energy-saving products in their businesses can qualify for a tax deduction under EPACT. Buildings must achieve a 50 percent reduction in

428

ORNI 9, LLC, AND ORMAT NEVADA INC. APPLICATIONS FOR PERMIT TO DRILL  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

ORNI 9, LLC, AND ORMAT NEVADA INC. ORNI 9, LLC, AND ORMAT NEVADA INC. APPLICATIONS FOR PERMIT TO DRILL GEOTHERMAL OBSERVATION WELLS 82-14 AND 55-14 AND GEOTHERMAL PRODUCTION WELL 15-12 AND POSSIBLE FUTURE GEOTHERMAL WELLS LOCATED IN SECTIONS 12, and 14, T22N, R26E, MDB&M BLM Geothermal Leases NVN-065558 and NVN-065561 BLM Environmental Assessment No. NV-020-05-07 CONDITIONS OF APPROVAL 1. This approval is contingent upon the lessee/operator being in receipt of and in compliance with all appropriate federal, state, and local permits. 2. When cultural or paleontological resources, including but not limited to historic ruins, prehistoric artifacts and fossils, are discovered in the performance of the permit, the resources shall be left intact and immediately brought to the attention of the BLM authorized officer.

429

GRR/Section 20-FD-a - Well Abandonment Process | Open Energy Information  

Open Energy Info (EERE)

GRR/Section 20-FD-a - Well Abandonment Process GRR/Section 20-FD-a - Well Abandonment Process < GRR Jump to: navigation, search GRR-logo.png GEOTHERMAL REGULATORY ROADMAP Roadmap Home Roadmap Help List of Sections Section 20-FD-a - Well Abandonment Process 20FDAWellAbandonmentProcess.pdf Click to View Fullscreen Contact Agencies Bureau of Land Management Regulations & Policies Geothermal Resources Operational Order No.3 43 CFR 3200 et seq: Geothermal Resource Leasing 43 CFR 3263.10-3263.15: Well Abandonment Triggers None specified Click "Edit With Form" above to add content 20FDAWellAbandonmentProcess.pdf Error creating thumbnail: Page number not in range. Error creating thumbnail: Page number not in range. Error creating thumbnail: Page number not in range. Flowchart Narrative A geothermal lessee/operator is required to promptly plug and abandon

430

CX-003332: Categorical Exclusion Determination | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

2: Categorical Exclusion Determination 2: Categorical Exclusion Determination CX-003332: Categorical Exclusion Determination Reclamation Projects on Wedding Bell Mountain Lease Tract C-WM-17, Uranium Leasing Program CX(s) Applied: B1.28 Date: 07/30/2010 Location(s): Montrose County, Colorado Office(s): Legacy Management The U.S. Department of Energy (DOE) Office of Legacy Management (LM) proposes several minor reclamation activities related to abandoned mines and mine features that pose a public safety concern. In 2007, LM inherited abandoned mines as a result of re-aligning lease tract boundaries. Independent contractors associated with the lessee (Golden Eagle Uranium) and under the supervision of uranium leasing program personnel would complete the work, and all projects would be completed within approximately

431

Statistical characterization of the federal geothermal leasing and permitting program. Final report, April 18, 1978-January 31, 1979  

DOE Green Energy (OSTI)

The ineffectiveness thus far in the federal geothermal leasing program is documented. Leases have been issued on only 18% of non-competitive applications on land under BLM jurisdiction and 2% of applied-for National Forest land. It has taken an average of about two years to get a lease, although the time lapses involved are extremely erratic, and many applications have been pending since January 1974, the first month applications were accepted. Some gradual improvement in BLM performance was demonstrated, however. Only about 250 competitive leases have been issued on the 50% of BLM acreage and the 2% of KGRA acreage in National Forests which has been offered. The US Geological Survey postlease permitting performance is also non-uniform in timeframes required for approvals. To some extent, this has resulted from stated lessee priority.

Beeland, G.V.; Ludington, J.A.; Schumann, E.

1979-01-01T23:59:59.000Z

432

Statistical characterization of the Federal Geothermal Leasing and Permitting Program. Final report, 18 April 1978-31 January 1979  

DOE Green Energy (OSTI)

The ineffectiveness thus far in the Federal geothermal leasing program is documented. Leases have been issued on only 18 percent of non-competitive applications on land under BLM jurisdiction and two percent of applied-for National Forest land. It has taken an average of about two years to get a lease, although the time lapses involved are extremely erratic, and many applications have been pending since January 1974, the first month applications were accepted. Some gradual improvement in BLM performance was demonstrated, however. Only about 250 competitive leases have been issued on the 50 percent of BLM KGRA acreage and the two percent of KGRA acreage in National Forests which has been offered. The US Geological Survey postlease permitting performance is also non-uniform in timeframes required for approvals. To some extent, this has resulted from stated lessee priority.

Beeland, G.V.; Ludington, J.A.; Schumann, E.

1979-01-01T23:59:59.000Z

433

Technical Support Document: Development of the Advanced Energy Design Guide for Medium Box Retail -- 50% Energy Savings  

DOE Green Energy (OSTI)

This report provides recommendations that architects, designers, contractors, developers, owners, and lessees of medium box retail buildings can use to achieve whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004. The recommendations are given by climate zone and address building envelope, fenestration, lighting systems, HVAC systems, building automation and controls, outside air treatment, service water heating, plug loads, and photovoltaic systems. The report presents several paths to 50% savings, which correspond to different levels of integrated design. These are recommendations only, and are not part of a code or standard. The recommendations are not exhaustive, but we do try to emphasize the benefits of integrated building design, that is, a design approach that analyzes a building as a whole system, rather than as a disconnected collection of individually engineered subsystems.

Hale, E. T.; Macumber, D. L.; Long, N. L.; Griffith, B. T.; Benne, K. S.; Pless, S. D.; Torcellini, P. A.

2008-09-01T23:59:59.000Z

434

ROCKY MOUNTAIN JOURNAL OF MATHEMATICS  

E-Print Network (OSTI)

factors of i = 1,...,t, j = 1,...,n-1, by n, we have nfAjm+i = (jmnf +nif -nf +n).-.(jmnf +nif) = (.(if - f +1) -j)...(nif - j) (modp), so that Multiplying both sides of this congruence by Bn = n(2n) .(tf n

Williams, Kenneth Stuart

435

LINE","COMPNAME","COMPID","YEAR","PURCNAME","SALETYPE","MEGAWATT...  

U.S. Energy Information Administration (EIA) Indexed Site

Spencer City of",554,1999,"Iowa State University","NF",3543,0,0,87758,87758 2,"Spencer City of",554,1999,"Alliant","NF",28,0,0,1443,1443 3,"Spencer City of",554,1999,"Mid-America...

436

Cytokine-Induced Signaling Networks Prioritize Dynamic Range  

E-Print Network (OSTI)

. For example, the transcription factor nuclear factor-kB (NF-kB) is widely regarded as a prosurvival protein-IAP2, Bcl-xL, and c-FLIP (Karin and Lin, 2002). In response to DNA-damaging agents, however, nuclear NF-kB

437

Noise-Limited Frequency Signal Transmission in Gene Circuits Cheemeng Tan,* Faisal Reza,*y  

E-Print Network (OSTI)

clocks (2), Ca21 signaling pathways (3,4), p53 DNA repair pathways (5), NF-kB pathways (6), and cell of ;0.008/s significantly increased the activity of Ras proteins (22). Similarly, the frequency of NF-kB

You, Lingchong

438

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer  

E-Print Network (OSTI)

(Watanabe et al., 2008). NOD2 stimulation leads to the activation of MAP kinase and NF-kB signaling pathways). Together, these studies suggest that innate immune signaling triggered by the commensal bacteria-TLR or NOD-NF-kB

439

Molecular Cell Short Article  

E-Print Network (OSTI)

of an HBO1 complex, ING4 has also been reported to repress transcription of the NF-kB and hypoxia response to directly interact with the RelA subunit of NF-kB and with Egln1/HPH2 (hypoxia inducible factor Prolyl

Gozani, Or

440

Molecular Cell Control of Proinflammatory Gene  

E-Print Network (OSTI)

-depen- dent erasure of H4K20me3 is required for effective gene activation and is achieved by NF-kB-depen- dent such as nuclear factor-k B (NF-kB), activator protein 1 (AP1), and interferon regulatory factor (IRFs

Higgins, Darren

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis  

E-Print Network (OSTI)

of signal 1 (NF-kB), the NLRP3 inflammasome was activated by mitochon- drial apoptotic signaling activation (Latz, 2010). The first signal (signal 1), often NF-kB activation, induces pro-IL-1b and NLRP3

442

Identification of genetic variation and putative regulatory regions in bovine CARD15  

E-Print Network (OSTI)

have an enhanced ability to activate nuclear factor kappa-B (NF-kB) (Miceli-Richard et al. 2001), while components resulting in a perturbation of NF-kB activation (Girardin et al. 2003; Gutierrez et al. 2002

Taylor, Jerry

443

Tumor and Stem Cell Biology Akt2 Regulates All Akt Isoforms and Promotes Resistance to  

E-Print Network (OSTI)

of NF-kB, cAMP responsive element­binding protein (CREB), and CBP/p300 to the miR-21 promoter (6). The LKB1/AMPK pathway on the other hand, inhibits mTOR and activates NF-kB and Notch1

444

NIKKI GEORGINA TRAYLOR-KNOWLES ntk1717@gmail.com (410) 905-5107  

E-Print Network (OSTI)

., Goucher, H., Finnerty, J.R., Gilmore, T.D. (2010) Characterization of the core elements of the NF-kB., Gilmore, T.D., and Finnerty, J.R. (2009) Two alleles encoding transcription factor NF-kB in the sea

Palumbi, Stephen

445

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

ty",6,3,"AVISTA","NF",573733,,,22608999,22608999 3413,"PUD No 1 of Chelan County",6,4,"BC HYDRO","NF",5,,,211,211 3413,"PUD No 1 of Chelan County",6,5,"BENTON COUNTY...

446

Property:SurfaceManager | Open Energy Information  

Open Energy Info (EERE)

SurfaceManager SurfaceManager Jump to: navigation, search Property Name SurfaceManager Property Type Page Pages using the property "SurfaceManager" Showing 25 pages using this property. (previous 25) (next 25) A AZA-009168 + COCONINO NF + AZA-009169 + COCONINO NF + AZA-009170 + COCONINO NF + AZA-009171 + FOREST SERVICE + AZA-009172 + FOREST SERVICE + AZA-009173 + FOREST SERVICE + AZA-009174 + FOREST SERVICE + AZA-009175 + COCONINO NF + AZA-009176 + BUREAU OF LAND MGMT + AZA-009177 + FOREST SERVICE + AZA-009178 + FOREST SERVICE + AZA-009179 + FOREST SERVICE + AZA-009180 + FOREST SERVICE + AZA-009181 + FOREST SERVICE + AZA-009182 + FOREST SERVICE + AZA-009183 + FOREST SERVICE + AZA-009184 + FOREST SERVICE + AZA-009185 + FOREST SERVICE + AZA-009186 + COCONINO NF +

447

Table HC1-9a. Housing Unit Characteristics by Northeast Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

9a. Housing Unit Characteristics by Northeast Census Region, 9a. Housing Unit Characteristics by Northeast Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. Northeast Census Region RSE Row Factors Total Census Division Middle Atlantic New England 0.5 1.0 1.2 1.6 Total .............................................................. 107.0 20.3 14.8 5.4 NE Census Region and Division Northeast ..................................................... 20.3 20.3 14.8 5.4 NF New England ............................................. 5.4 5.4 Q 5.4 NF Middle Atlantic ........................................... 14.8 14.8 14.8 Q NF Midwest ....................................................... 24.5 -- -- -- NF East North Central ..................................... 17.1 -- -- -- NF

448

Study of Possible Ultraviolet Zero of the Beta Function in Gauge Theories with Many Fermions  

E-Print Network (OSTI)

We study the possibility of an ultraviolet (UV) zero in the $n$-loop beta function of U(1) and non-Abelian gauge theories with $N_f$ fermions for large $N_f$. The effect of scheme transformations on the coefficients of different powers of $N_f$ in the $n$-loop term in the beta function is calculated. A general scheme-independent criterion is given for determining whether or not the $n$-loop beta function has a UV zero for large $N_f$. We compare the results with exact integral representations of the leading terms in the beta functions for the respective Abelian and non-Abelian theories in the limit $N_f \\to \\infty$ limit with $N_f \\alpha$ finite. As part of this study, new analytic and numerical results are presented for certain coefficients, denoted $b_{n,n-1}$, that control the large-$N_f$ behavior at $n$-loop order in the beta function. We also investigate various test functions incorporating a power-law and essential UV zero in the beta function and determine their manifestations in series expansions in powers of coupling and in powers of $1/N_f$.

Robert Shrock

2013-11-20T23:59:59.000Z

449

Somatic mosaicism in a patient with neurofibromomatosis type 1  

SciTech Connect

Using loss of heterozygosity analysis, a method designed to detect moderate to large gene deletions, we have identified a new-mutation neurofibromatosis type 1 (NF1) patient who is somatically mosaic for a large maternally derived deletion in the NF1 gene region. The deletion extends at least from exon 4 near the 5{prime} end of the gene to intron 39 near the 3{prime} end. The gene-coding region is, therefore, mostly or entirely deleted, encompassing a loss of {>=}100 kb. We hypothesize that the deletion occurred at a relatively early developmental timepoint, since signs of NF in this patient are not confined to a specific body region, as seen in {open_quotes}segmental{close_quotes} NF, and since both mesodermally and ectodermally derived cells are affected. This report provides the first molecular evidence of somatic mosaicism in NF1 and, taken together with a recent report of germ-line mosaicism in NF1, adds credence to the concept that mosaicism plays an important role in phenotypic and genetic aspects of NF1 and may even be a relatively common phenomenon. 37 refs., 4 figs.

Colman, S.D.; Rasmussen, S.A.; Ho, V.T. [Univ. of Florida, Gainesville, FL (United States)] [and others

1996-03-01T23:59:59.000Z

450

Immunoglobulin motif DNA recognition and  

E-Print Network (OSTI)

binding domains of NF-kB, NFAT1, p53 and the STAT proteins. NMR spectroscopy of a 43.6 kD RD­b­DNA ternary for NF-kB3-4, the nuclear factor of acti- vated T-cells NFAT1 (refs 5,6), STAT1 (ref. 7) and STAT3b8 72 and Ser 73. In con- trast, the N-terminus of NF-kB3-4 and NFAT1 (refs 5, 6) loops around

Sali, Andrej

451

Identificado un nuevo indicador de recada en el cncer de mama http://www.lavanguardia.com/salud/20120619/54313501609/identificado-nuevo-indicador-recaida-cancer-mama.html[19/06/2012 12:09:50  

E-Print Network (OSTI)

células para activar la señalización de un complejo proteico llamado NF-kB que está relacionado con la activación de NF-kB en los tumores, como el mejor indicador de recaída en las pacientes de cáncer de mama, en requerimiento esencial para que se mantenga activado de manera crónica el complejo NF-kB, asociado a la invasión

Foissac, Sylvain

452

Nepali Aawaz Volume 1, Issue 2, 13-18 October 2005  

E-Print Network (OSTI)

/f]xÆdf g]kfnsf Vofltk|fKt nf]sufos >L k|]d/fhf dxtsf] ælxdfnog Do"lhs ;d"xÆn] df}sf kfPsf] 5 . hfgsf/L cg';f/ …g]zgn sfplG;n km/ b 6«]l8;gn cf6{;\\Ú n] jfl;Ë6g l8=;L= l: yt g]kfnL /fhb"tfjf;nfO{ Ps kq n]vL nf]s ufos >L k|]d/fhf dxt / pgsf] ;fF:s[lts 6...

Shrestha, Kashish Das

453

Parity Doubling and the S Parameter Below the Conformal Window  

E-Print Network (OSTI)

We describe a lattice simulation of the masses and decay constants of the lowest-lying vector and axial resonances, and the electroweak S parameter, in an SU(3) gauge theory with $N_f = 2$ and 6 fermions in the fundamental representation. The spectrum becomes more parity doubled and the S parameter per electroweak doublet decreases when $N_f$ is increased from 2 to 6, motivating study of these trends as $N_f$ is increased further, toward the critical value for transition from confinement to infrared conformality.

Thomas Appelquist; Ron Babich; Richard C. Brower; Michael Cheng; Michael A. Clark; Saul D. Cohen; George T. Fleming; Joe Kiskis; Meifeng Lin; Ethan T. Neil; James C. Osborn; Claudio Rebbi; David Schaich; Pavlos Vranas

2010-09-29T23:59:59.000Z

454

Table HC1-10a. Housing Unit Characteristics by Midwest Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

0a. Housing Unit Characteristics by Midwest Census Region, 0a. Housing Unit Characteristics by Midwest Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. Midwest Census Region RSE Row Factors Total Census Division East North Central West North Central 0.5 1.0 1.2 1.8 Total .............................................................. 107.0 24.5 17.1 7.4 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- NF New England ............................................. 5.4 -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- NF Midwest ....................................................... 24.5 24.5 17.1 7.4 NF East North Central ..................................... 17.1 17.1

455

Microsoft Word - Chapter 04.doc  

National Nuclear Security Administration (NNSA)

poorly welded tuff layer. This would reduce the number of trucks transporting concrete mix from the batch plant to the Modified CMRR-NF. While the total number of trucks would be...

456

outbind://6-000000007B09B0C78182DD468D210820B7D48C0A070041ECF0B  

National Nuclear Security Administration (NNSA)

11172010 Dear Mr. John Tegtmeir, I have attached comments from Tewa Women United for the CMRR-NF. I do hope they are taken seriously and worthy of some more dialogues into the...

457

Primal-dual subgradient method for Huge-Scale Linear Conic ...  

E-Print Network (OSTI)

For N ? 0, denote by FN the set of iterations of type (F), which were used for generating the point yN+1. And let GN def. = {0,...,N}\\FN , Nf def. = |FN |, and Ng def.

458

On the Globally Concavized Filled Function Method ?  

E-Print Network (OSTI)

The test results of the above 8 problems are presented in Table 1. Table 1. Numerical results of the algorithm. Problem No. n. NF. NG. NFF. NFG. LNF. LNG.

459

S:\VM3\RX97\TBL_LIST.WPD  

U.S. Energy Information Administration (EIA) Indexed Site

b. Housing Unit Characteristics by Four Most Populated States, b. Housing Unit Characteristics by Four Most Populated States, Percent of U.S. Households, 1997 Housing Unit Characteristics RSE Column Factor: Total Four Most Populated States RSE Row Factors New York California Texas Florida 0.4 1.1 1.1 1.2 1.7 Total .............................................................. 100.0 100.0 100.0 100.0 100.0 0.0 Census Region and Division Northeast ..................................................... 19.4 100.0 -- -- -- NF New England ............................................. 5.2 Q -- -- -- NF Middle Atlantic ........................................... 14.2 100.0 -- -- -- NF Midwest ....................................................... 23.7 -- -- -- -- NF East North Central ..................................... 16.7 --

460

2008ENGINEERING SCHOLARS PROGRAM 2008 JOURNAL  

E-Print Network (OSTI)

St. Marie Madeleine Parish By Akua Abu, Andrew Acevedo, Ari Bogotch, Jared Carron, Adam Carter, including the 470 nF capacitor and25. 1 M resistor at the buffer amplifier input. The capacitor is used

Marques, Oge

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Design and synthesis of probes for detection of protein-protein interaction and RNA localization  

E-Print Network (OSTI)

The use of the ketone biotin - benzophenone-biotin hydrazide system for detecting the formation of cyan fluorescent protein and NF-kappaB p50 dimers was assessed. A series of benzophenone-based probes were synthesized and ...

Ryan, Jeremy Adam

2005-01-01T23:59:59.000Z

462

Nitrogen trifluoride global emissions estimated from updated atmospheric measurements  

E-Print Network (OSTI)

Nitrogen trifluoride (NF[subscript 3]) has potential to make a growing contribution to the Earth’s radiative budget; however, our understanding of its atmospheric burden and emission rates has been limited. Based on a ...

Ivy, Diane J.

463

Robust Efficient Frontier Analysis with a Separable Uncertainty Model  

E-Print Network (OSTI)

Institute on Energy Efficiency, by Army award W911NF-07-1-0029, by NSF award ECS-. 0423905, by NSF award .... [29] R. Green and B. Hollifield. When will ...

464

Surface Electrode Ion Microtrap Fabrication 729nm ECDL with ...  

Science Conference Proceedings (OSTI)

... vs. 1.3 fF/µm2). • Capacitors are located within microns of DC electrode. • 1nF trench capacitor is about ... ultra-high vacuum GR Brady et al. ...

2011-03-01T23:59:59.000Z

465

Career Options Program/Courses Resources Why Choose Computer Engineering  

E-Print Network (OSTI)

? · Design things that people use. · Computers, personal electronics. · Cars, planes etc. -- much/Courses Resources Employers Utilities NL Hydro, NF Power, Aliant, Ontario Hydro Resource/Heavy Industry Petro

Peters, Dennis

466

Bioremediation of contaminated groundwater  

DOE Patents (OSTI)

Disclosed is an apparatus and method for in situ remediation of contaminated subsurface soil or groundwater contaminated by chlorinated hydrocarbons. A nutrient fluid (NF) is selected to simulated the growth and reproduction of indigenous subsurface microorganisms capable of degrading the contaminants; an oxygenated fluid (OF) is selected to create an aerobic environment with anaerobic pockets. NF is injected periodically while OF is injected continuously and both are extracted so that both are drawn across the plume. NF stimulates microbial colony growth; withholding it periodically forces the larger, healthy colony of microbes to degrade the contaminants. Treatment is continued until the subsurface concentration of contaminants is acceptable. NF can be methane and OF be air, for stimulating production of methanotrophs to break down chlorohydrocarbons, especially TCE and tetrachloroethylene.

Hazen, T.C.; Fliermans, C.B.

1994-01-01T23:59:59.000Z

467

Process Mineralogy  

Science Conference Proceedings (OSTI)

"The Exhumed 'Carlin-Type' Fossil Oil Reservoir at Yankee Basin" (Overview), J.B. Hulen, J.W. Collister, B. Stout, D.K. Curtiss, and N.F. Dahdah, December ...

468

Microsoft Word - Appendix C.doc  

National Nuclear Security Administration (NNSA)

fraction values are also taken from the hazard analysis information for the CMR Building and CMRR-NF (LANS 2011a, 2011b), or the DOE Handbook on airborne release...

469

PolynomialIdeals.f4 - CECM - Simon Fraser University  

E-Print Network (OSTI)

... construct a lookup table for monomials (used by nf_proc) mbasis := [seq( mbasis[i],i=1..n)]; basis_lookup := table(zip(`=`,mbasis,[seq(i,i=1..n)])); # initialize XLA ...

470

CRYOPUMP BEHAVIOR IN THE PRESENCE OF BEAM OR NUCLEAR RADIATION  

E-Print Network (OSTI)

63, 151 T. Kaimcash. Fusion Reactor Physics (Ann ArborTritium Technology For Fusion Reactors. C0NF-750989 (OakA. Impurity Effects in Fusion Reactor Operations B.

Law, P.K.

2011-01-01T23:59:59.000Z

471

Structure and Biochemistry of IKappaB Zeta : : A Nuclear IKappaB Protein  

E-Print Network (OSTI)

NF-?B Nuclear factor -?B NSLS National Synchrotron LightSynchrotron Light Source (NSLS) in Brookhaven. We used thePDB accession code NSLS#25 P65 Data in parentheses are for

Zhu, Norman L.

472

appl_household2001.pdf  

Annual Energy Outlook 2012 (EIA)

... Q Q Q Q Q NF Other Appliances Automobile BlockEngine Battery Heater ... 0.5 0.3 Q 0.1 Q 37.2 Ceiling Fans...

473

Review Accurate thermochemistry from quantum chemical ...  

Science Conference Proceedings (OSTI)

Lipkowitz KB (eds) Rev Comp Chem 15:147; b) Curtiss. LA, Raghavachari K .... 46. a) Dorofeeva OV, Iorish VS, Moiseeva NF (1999) J Chem. Eng Data 44:516; ...

474

Large size fibrillar bundles of the Alzheimer amyloid b-protein  

Science Conference Proceedings (OSTI)

Stokes–Einstein relation: kBTD–1 = 6pgRh, where kB is the. Boltzmann constant ..... height hc and the aggregation number nf are less robust parameters, since ...

475

Carbon Free Developments | Open Energy Information  

Open Energy Info (EERE)

Developments Jump to: navigation, search Name Carbon Free Developments Place United Kingdom Zip W11 3NF Sector Wind energy Product UK-based onshore wind project developer. The firm...

476

Project Title  

NLE Websites -- All DOE Office Websites (Extended Search)

plant possible * Other options: - Agricultural and potable water for local use - Saline cooling towers * Use softened water from NF - Saline oil-field make-up waters (11 wt %...

477

The NOAA Hydrometeorology Testbed Soil Moisture Observing Networks: Design, Instrumentation, and Preliminary Results  

Science Conference Proceedings (OSTI)

The NOAA Hydrometeorology Testbed (HMT) program has deployed soil moisture observing networks in the watersheds of the Russian River and the North Fork (NF) of the American River in northern California, and the San Pedro River in southeastern ...

Robert J. Zamora; F. Martin Ralph; Edward Clark; Timothy Schneider

2011-09-01T23:59:59.000Z

478

Improved nuclear matter calculations from chiral low-momentum interactions  

Science Conference Proceedings (OSTI)

We present nuclear matter calculations based on low-momentum interactions derived from chiral effective field theory potentials. The current calculations use an improved treatment of the three-nucleon force (3NF) contribution that includes a corrected combinatorial factor beyond Hartree-Fock that was omitted in previous nuclear matter calculations. We find realistic saturation properties using parameters fit only to few-body data, but with larger uncertainty estimates from cutoff dependence and the 3NF parametrization than in previous calculations.

Hebeler, K. [TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A3 (Canada); Department of Physics, Ohio State University, Columbus, Ohio 43210 (United States); Bogner, S. K. [National Superconducting Cyclotron Laboratory and Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48844 (United States); Furnstahl, R. J. [Department of Physics, Ohio State University, Columbus, Ohio 43210 (United States); Nogga, A. [Institute for Advanced Simulations, Institut fuer Kernphysik and Juelich Centre for Hadron Physics, Forschungszentrum Juelich, D-52425 Juelich (Germany); Schwenk, A. [ExtreMe Matter Institute EMMI, GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Institut fuer Kernphysik, Technische Universitaet Darmstadt, D-64289 Darmstadt (Germany)

2011-03-15T23:59:59.000Z

479

1. "Kopfzahlen" -Insgesamt Studienanfnger im 1. Hochschulsem. 527 605 613 545 433  

E-Print Network (OSTI)

- - Gesamt 0 0 0 39 908 921 1.107 1.200 Chemie Biochemie * Bachelor - - - - 37 - - - Chemie Bachelor KF - 4 6.309 Deutsch als Bachelor KF 44 37 32 - 185 119 67 - Fremdsprache Bachelor NF 10 15 11 - 46 37 18 - (Interkult(42) 50(50) 120 - 860 681 492 - Deutsch Bachelor NF 17(15) 14 (10) 35 - 184 136 107 - Gesamt 61 64 155 188

Moeller, Ralf

480

NETL: Water-Energy Interface - Power Plant Water Management  

NLE Websites -- All DOE Office Websites (Extended Search)

Nanofiltration Treatment Options for Thermoelectric Power Plant Water Treatment Demands Nanofiltration Treatment Options for Thermoelectric Power Plant Water Treatment Demands Sandia National Laboratories (SNL) is conducting a study on the use of nanofiltration (NF) treatment options to enable use of non-traditional water sources as an alternative to freshwater make-up for thermoelectric power plants. The project includes a technical and economic evaluation of NF for two types of water that contain moderate to high levels of total dissolved solids (TDS): (1) cooling tower recirculating water and (2) produced waters from oil & gas extraction operations. Reverse osmosis (RO) is the most mature and commonly considered option for high TDS water treatment. However, RO is generally considered to be too expensive to make treatment of produced waters for power plant use a feasible application. Therefore, SNL is investigating the use of NF, which could be a more cost effective treatment option than RO. Similar to RO, NF is a membrane-based process. Although NF is not as effective as RO for the removal of TDS (typical salt rejection is ~85 percent, compared to >95 percent for RO), its performance should be sufficient for typical power plant applications. In addition to its lower capital cost, an NF system should have lower operating costs because it requires less pressure to achieve an equivalent flux of product water.

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481

Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription  

SciTech Connect

Leukocyte adherence to endothelium is in part mediated by the transient expression of endothelial-leukocyte adhesion molecule 1 (ELAM-1) on endothelial surfaces stimulated by tumor necrosis factor {alpha} (TNF), interleukin (IL) 1, or bacterial lipopolysaccharide (LPS). The intracellular factors controlling induction of ELAM-1 mRNA and protein are unknown. In nuclear runoff experiments with cultured human umbilical vein endothelial cells (HUVEC), the authors demonstrate that transcriptional activation of the ELAM-1 gene occurs following stimulation with TNF. Sequence analysis of the 5{prime} flanking region of the ELAM-1 gene reveals consensus DNA-binding sequences for two known transcription factors, NF-{kappa}B and AP-1. Gel mobility shift assays demonstrate that TNF, IL-1, or LPS induces activation of NF-{kappa}B-like DNA binding activity in HUVEC. Phorbol 12-myristate 13-acetate, a known activator of protein kinase C (PKC), weakly induces NF-{kappa}B-like activity, ELAM-1 mRNA, and ELAM-1 surface expression in HUVEC. However, TNF, IL-1, and LPS do not activate PKC in HUVEC at doses that strongly induce NF-{kappa}B-like protein activation and ELAM-1 gene expression. PKC blockade with H7 does not inhibit activation of these NF-kB-like proteins but does inhibit ELAM-1 gene transcription. They conclude that PKC-independent activation of NF-{kappa}B in HUVEC with TNF, IL-1, or LPS is associated with, but not sufficient for, activation of ELAM-1 gene transcription.

Montgomery, K.F.; Tarr, P.I.; Bomsztyk, K.; Harlan, J.M.; Pohlman, T.H. (Univ. of Washington, Seattle (United States)); Osborn, L.; Hession, C.; Tizard, R.; Goff, D.; Vassallo, C.; Lobb, R. (Biogen, Inc., Cambridge, MA (United States))

1991-08-01T23:59:59.000Z

482

Activation of nuclear factor kB in human lymphoblastoid cells by low-dose ionizing radiation  

SciTech Connect

Nuclear factor kB (NF-kB) is a pleiotropic transcription factor which is involved in the transcriptional regulation of several specific genes. Recent reports demonstrated that ionizing radiation in the dose range of 2-50 Gy results in expression of NF-kB in human KG-1 myeloid leukemia cells and human B-lymphocyte precursor cells; the precise mechanism involved and the significance are not yet known. The present report demonstrates that even lower doses of ionizing radiation, 0.25-2.0 Gy, are capable of inducing expression of NF-kB in EBV-transformed 244B human lymphoblastoid cells. These results are in a dose range where the viability of the cells remains very high. After exposure to {sup 137}Cs {gamma} rays at a dose rate of 1.17 Gy/min, a maximum in expression of NF-kB was seen at 8 h after a 0.5-Gy exposure. Time-course studies revealed a biphasic time-dependent expression after 0.5-, 1- and 2-Gy exposures. However, for each time examined, the expression of NF-kB was maximum after the 0.5-Gy exposure. The expression of the p50 and p65 NF-kB subunits was also shown to be regulated differentially after exposures to 1.0 and 2.0 Gy. 32 refs., 3 figs.

Prasad, A.V.; Mohan, N.; Meltz, M.L.; Chandrasekar, B. [Univ. of Texas Health Science Center, San Antonio, TX (United States)

1994-06-01T23:59:59.000Z

483

Conformal Window and Correlation Functions in Lattice Conformal QCD  

E-Print Network (OSTI)

We discuss various aspects of Conformal Field Theories on the Lattice. We mainly investigate the SU(3) gauge theory with N_f degenerate fermions in the fundamental representation, employing the one-plaquette gauge action and the Wilson fermion action. First we make a brief review of our previous works and thereby clarify the reason why we conjecture that the conformal window is 7 le N_f le 16. Secondly, we introduce a new concept, "conformal theories with an IR cutoff" and point out that any numerical simulation on a lattice is bounded by an IR cutoff Lambda_{IR}. Then we make predictions that when N_f is within the conformal window, the propagator of a meson G(t) behaves at large t, as G(t) = c exp(-m_H t)/t^alpha, that is, a modified Yukawa-type decay form, instead of the usual exponential decay form in the small quark mass region. This holds on an any lattice for any coupling constant g, as far as g is between 0 and g^*, where g^* is the IR fixed point. We verify that numerical results really satisfy the predictions for the N_f=7 case and the N_f=16 case. Thirdly, we discuss small number of flavors (N_f=2 sim 6) QCD at finite temperatures. We point out theoretically and verify numerically that the correlation functions at T/T_c > 1 exhibit the characteristics of the conformal function with IR cutoff, an exponential decay with power correction. Further, we observe our data are consistent with the picture that the N_f=7 case and the N_f=2 at T sim 2 T_c case are close to the meson unparticle model, and we estimate gamma^* = 1.2(1). On the other hand, the N_f=16 case and the N_f=2 at T= 10^2 sim 10^5 Tc cases are close to a free state in the Z(3) twisted vacuum. The results give clues for long standing issues such as slow approach of the free energy to the Stefan-Boltzmann ideal gas limit.

Y. Iwasaki

2012-12-18T23:59:59.000Z

484

TITLE  

Office of Legacy Management (LM)

Peccrdei et .... g:~.g-..o*c *ck .*,- Peccrdei et .... g:~.g-..o*c *ck .*,- &.-. fi+ E C 7 ---.----.- .-.... 3$rS --------- ixx4!30 F A ~ 953 ' 27565' glla 5tcpEe.l. Peeorder Reception N o . - STATE OF COtOPA00 COUFlTY OF GARFIELD MfEREAS, under date of kcember 7 , 1966, an oil and gas l e a s e was entered i n t o between Claude V. Hayward, lessor, snd Rustrat dl1 Ccmpany Incorporated, Lessee, covering, among other l a n d s , t a t 1 1 , being the Northeast Quarter ~b the Southwest Q u a r t e r o f Section 25, f - 7 4 , R-95-W, Garfield County, Calnrnda, sa3d lease being recorded O n 86ak 381, Fag? 418, o f the ~rritdrd$ of B a r f leld County, C s l o r e d ~ ; and @ WWEEA., under date o f l%y 5 , 1967, a U n l t Agrarmnt fas the Dcvelapmnt and Opcratlon o f the Rulison Vn4 t Area I n Gsrfield and He58 Counties Colorado, was entered 1 nto betwen Aus t r

485

Data:5d174ba3-5790-4676-a3d6-8c3cd18ef8e4 | Open Energy Information  

Open Energy Info (EERE)

4ba3-5790-4676-a3d6-8c3cd18ef8e4 4ba3-5790-4676-a3d6-8c3cd18ef8e4 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: PUD No 1 of Grays Harbor Cnty Effective date: 2010/02/01 End date if known: Rate name: Yard Lighting Schedule 88 HPS 100W Sector: Lighting Description: This schedule is applicable to all property owners or long term lessees of property with yard light service. Source or reference: https://www.ghpud.org/index.php?option=com_content&view=article&id=120:yard-lighting&catid=114:rates&Itemid=207 Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW):

486

DOE Uranium Leasing Program - Lease Tract Metrics  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Uranium Leasing Program -- Lease Tract Metrics Uranium Leasing Program -- Lease Tract Metrics Lease Tract Lessee Lease Date Bid (%) Reclamation Bond a Total Acres Acres Excluded b Comment C-JD-5 Gold Eagle Mining, Inc. 04/30/08 12.00 37,000 150.71 C-JD-5A Golden Eagle Uranium, LLC 06/27/08 20.10 5,000 24.54 C-JD-6 Cotter Corporation 04/30/08 14.20 19,000 530.08 C-JD-7 c Cotter Corporation 04/30/08 27.30 1,206,000 493.01 C-JD-8 Cotter Corporation 04/30/08 36.20 4,000 954.62 C-JD-8A No bids received - remains inactive N/A N/A N/A 77.91 C-JD-9 Cotter Corporation 04/30/08 24.30 72,000 1,036.50 C-SR-10 Golden Eagle Uranium, LLC 06/27/08 13.10 5,000 637.64 C-SR-11 Cotter Corporation 04/30/08 11.67 43,000 1,303.22 200.25 Summit Canyon area excluded from lease tract C-SR-11A Golden Eagle Uranium, LLC 06/27/08 14.30 5,000 1,296.81 C-SR-12 Colorado Plateau Partners 06/27/08

487

Data:513098e8-96f9-4c34-9bb9-ad6e2a7617e3 | Open Energy Information  

Open Energy Info (EERE)

96f9-4c34-9bb9-ad6e2a7617e3 96f9-4c34-9bb9-ad6e2a7617e3 No revision has been approved for this page. It is currently under review by our subject matter experts. Jump to: navigation, search Loading... 1. Basic Information 2. Demand 3. Energy << Previous 1 2 3 Next >> Basic Information Utility name: PUD No 1 of Grays Harbor Cnty Effective date: 2010/02/01 End date if known: Rate name: Yard Lighting Schedule 88 HPS 200W Sector: Lighting Description: This schedule is applicable to all property owners or long term lessees of property with yard light service. Source or reference: https://www.ghpud.org/index.php?option=com_content&view=article&id=120:yard-lighting&catid=114:rates&Itemid=207 Source Parent: Comments Applicability Demand (kW) Minimum (kW): Maximum (kW): History (months):

488

Air Force Enhanced Use Lease  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1 1 Air Force Enhanced Use Lease Mr. Brian Brown 16 Oct. 12 I n t e g r i t y - S e r v i c e - E x c e l l e n c e 2 Agenda  Brian Brown  Enhanced Use Lease (EUL) Overview  Energy EULs  EUL Goals  David Swanson  Energy EUL Market Drivers  Current EUL Projects  Partnering with the Air Force  Contact Information I n t e g r i t y - S e r v i c e - E x c e l l e n c e 3 Overview  Authority 10 USC 2667  An EUL is a lease  By the government  Of "non-excess" property  Under the control of the government  To a public or private sector lessee  In exchange for fair market value rental payments in cash and/or in kind consideration I n t e g r i t y - S e r v i c e - E x c e l l e n c e

489

Proposed natural gas protection program for Naval Oil Shale Reserves Nos. 1 and 3, Garfield County, Colorado  

SciTech Connect

As a result of US Department of Energy (DOE) monitoring activities, it was determined in 1983 that the potential existed for natural gas resources underlying the Naval Oil Shales Reserves Nos. 1 and 3 (NOSrs-1 3) to be drained by privately-owned gas wells that were being drilled along the Reserves borders. In 1985, DOE initiated a limited number of projects to protect the Government's interest in the gas resources by drilling its own offset production'' wells just inside the boundaries, and by formally sharing in the production, revenues and costs of private wells that are drilled near the boundaries ( communitize'' the privately-drilled wells). The scope of these protection efforts must be expanded. DOE is therefore proposing a Natural Gas Protection Program for NOSRs-1 3 which would be implemented over a five-year period that would encompass a total of 200 wells (including the wells drilled and/or communitized since 1985). Of these, 111 would be offset wells drilled by DOE on Government land inside the NOSRs' boundaries and would be owned either entirely by the Government or communitized with adjacent private land owners or lessees. The remainder would be wells drilled by private operators in an area one half-mile wide extending around the NOSRs boundaries and communitized with the Government. 23 refs., 2 figs., 6 tabs.

1991-08-01T23:59:59.000Z

490

Financing; A Cost Effective Alternative When Upgrading Energy Efficient Systems  

E-Print Network (OSTI)

In the 1990's, many organizations are attempting to do more, faster, with less cost and improved quality. In many cases, this involves improving the efficiency of their systems. Increased competition is creating pressure to continuously improve in order to effectively compete in the marketplace. One obvious method of reducing costs and improving productivity is to upgrade old, antiquated equipment such as lighting to more modern energy efficient systems. Most projects provide a return on investment to the owner in several years, through energy and demand savings, Power Utility rebates, maintenance savings and increased productivity, however, the initial capital expense required is cost prohibitive. Budget constraints, a lengthy and complicated approval process and large up-front capital requirements are only a few "road blocks" to improvement. In order to make an equipment acquisition, every company must consider how they will pay for it! How do companies acquire the equipment they need to be more competitive? One cost effective solution -FINANCING! There are numerous benefits to both the end user customer (Lessee) and the installing contractor from utilizing financing to upgrade or retrofit to energy efficient systems. It is possible to provide design, material, installation, maintenance and soft costs as well as positive cash flow to the end user by structuring financing terms and payments around the energy savings. A wide array of programs and services are offered by many different financial organizations.

Ertle, J. M.

1994-04-01T23:59:59.000Z

491

Genotoxicity of complex chemical mixtures  

E-Print Network (OSTI)

Complex chemical mixtures are ubiquitous in the environment. Humans are frequently exposed to these mixtures; therefore, it is important to understand potential interactions of chemical mixtures. Mixture interactions may influence the absorption, distribution, metabolism or excretion of the components of a complex mixture. The research conducted for this dissertation has coupled chemical fractionation with in vitro and in vivo bioassays to assess the potential carcinogenic risk of complex mixtures. A non-aqueous phase liquid from a wood treatment plant was separated into acid (AF), base (BF) and neutral fractions (NF). The NF was further enriched using column chromatography to produce a polychlorinated dinbenzo-p-dioxin (PCDD) and a polycyclic aromatic hydrocarbon (PAH) fraction. The genotoxicity of these mixtures were assessed via analytical quantification, in vitro (Salmonella microsome and E. coli prophage induction) and in vivo (32P-postlabeling) bioassays. The NF was further tested to measure bulky DNA adducts and induction of tumor formation. The AF contained the highest level of pentachlorophenol and the highest concentration of total PAHs. Although the carcinogenic PAHs were highest in the PCDD fraction, the highest concentrations of benzo(a)pyrene (BAP), indeno(1,2,3-cd)pyrene and dibenz(a,h)anthracene were detected in the PAH fraction. A positive genotoxic response in Salmonella was induced by the crude extract, the PAH and BF, whereas the AF and BF induced a positive response in the E. coli assay. In vivo, the PAH fraction induced the highest DNA adduct frequencies in the lung. The NF, reconstituted mixture (RM) (which includes equivalent concentrations of seven carcinogenic PAHs in the NF), BAP and the NF amended with BAP (NF+BAP) were all tested in an infant mouse model. At the highest dose, after a 24 hr exposure, NF+BAP had the highest total DNA adducts measured in liver which was three to seven times higher than with other treatments. Adduct levels were comparable to the control after 280 days. The highest incidence of tumors was observed in the liver. At the high dose, NF+BAP elicited the highest incidence of tumors. The results of this research confirm previous studies and indicate that the carcinogenic potential of PAH mixtures may be greater than predicted by chemical analysis.

Phillips, Tracie Denise

2006-12-01T23:59:59.000Z

492

Life Cycle Nitrogen Trifluoride Emissions from Photovoltaics  

SciTech Connect

Amorphous- and nanocrystalline-silicon thin-film photovoltaic modules are made in high-throughput manufacturing lines that necessitate quickly cleaning the reactor. Using NF{sub 3}, a potent greenhouse gas, as the cleaning agent triggered concerns as recent reports reveal that the atmospheric concentrations of this gas have increased significantly. We quantified the life-cycle emissions of NF{sub 3} in photovoltaic (PV) manufacturing, on the basis of actual measurements at the facilities of a major producer of NF{sub 3} and of a manufacturer of PV end-use equipment. From these, we defined the best practices and technologies that are the most likely to keep worldwide atmospheric concentrations of NF{sub 3} at very low radiative forcing levels. For the average U.S. insolation and electricity-grid conditions, the greenhouse gas (GHG) emissions from manufacturing and using NF{sub 3} in current PV a-Si and tandem a-Si/nc-Si facilities add 2 and 7 g CO{sub 2eq}/kWh, which can be displaced within the first 1-4 months of the PV system life.

Fthenakis, V.

2010-10-25T23:59:59.000Z

493

Low Dose Radiation Research Program: Molecular Characterization of Survival  

NLE Websites -- All DOE Office Websites (Extended Search)

Survival Advantage, Bystander Effect, and Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Mohan Natarajan University of Texas Health Science Center Why this Project? To understand the molecular link between the activation of NF-kB and cellular outcomes such as better cell survival after low-LET radiation and to determine whether low dose radiation-induced NF-kB signaling can mediate telomerase activation and thus confer enhanced cell survival of normal aortic endothelial cells. Project Goals To determine whether low-linear energy transfer (LET) radiation can cause a positive feedback signal initiated by the activation of the NF-kB. To examine one of the mechanisms involving TNF-a as a signaling mediator, which could mediate the bystander effect through the generation

494

Low Dose Radiation Research Program: Radiation-Induced Nuclear Factor kB  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation-Induced Nuclear Factor kB mediates survival advantage by Radiation-Induced Nuclear Factor kB mediates survival advantage by Telomerase Activation. Authors: Natarajan M.,1 Mohan S.,2 Pandeswara, S.L.,1 and Herman T.S.1 Institutions: Departments of 1Radiation Oncology and 2Pathology, The University of Texas Health Science Center, San Antonio, Texas Activation of NF-kB in response to low doses of ionizing radiation was first shown in our laboratory. Although studies have shown that NF-kB plays an important role in anti-apoptotic function, little has been done to understand the molecular link between the activation of NF-kB and cellular outcome such as enhanced cell survival after low dose low-linear transfer (LET) radiation. Because upregulation of telomerase activity is associated with longevity and allows cells to escape from senescence, we hypothesize

495

EIS-0350-S1: Mitigation Action Plan | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Mitigation Action Plan Mitigation Action Plan EIS-0350-S1: Mitigation Action Plan Nuclear Facility Portion of the Chemistry and Metallurgy Research Building Replacement Project at Los Alamos National Laboratory, Los Alamos, NM This Mitigation Action Plan (MAP) describes mitigation and monitoring commitments for constructing and operating the Modified CMRR-NF. The commitments made in this MAP are designed to mitigate potentially adverse environmental consequences associated with the CMRR-NF Project as the CMRR-NF is constructed and operated, and as direct, indirect, and cumulative impacts from these actions occur over time. EIS-0350-S1-MAP-2011.pdf More Documents & Publications EIS-0350-S1: Final Supplemental Environmental Impact Statement EIS-0350-S1: Draft Supplemental Environmental Impact Statement

496

A Variable flavor number scheme for heavy quark production at small x.  

E-Print Network (OSTI)

flavour contribution to the proton structure functions {Fa} can be written as: Fa,H = 1 nf nf ? i=1 e2i [ (CNSa,qq + CPSa,qq)? ? + CSa,qg ? g + nfCNSa,qq ? qns ] + e2H [ CPSa,Hq ? ?+ CSa,Hg ? g ] , (1) 3Here we are concerned with heavy quarks which... are generated perturbatively, as opposed to intrinsic heavy flavour distri- butions, which would be present in the proton at all values of Q2 [25]. 2 Coefficient Order CSa,Hg O(?S) CPSa,Hq O(?2S) CPS,NS,Sa,qq O(?2S) CSa,qg O(?3S) Table 1: The leading order...

White, C D; Thorne, Robert S

497

Atmospheric Chemistry and Physics  

E-Print Network (OSTI)

Abstract. A 3-D chemistry-transport model has been applied to the Mexico City metropolitan area to investigate the origin of elevated levels of non-fossil (NF) carbonaceous aerosols observed in this highly urbanized region. High time resolution measurements of the fine aerosol concentration and composition, and 12 or 24 h integrated 14 C measurements of aerosol modern carbon have been performed in and near Mexico City during the March 2006 MILAGRO field experiment. The non-fossil carbon fraction (fNF), which is lower than the measured modern fraction (fM) due to the elevated 14 C in the atmosphere caused by nuclear bomb testing, is estimated from the measured fM and the source-dependent information on modern carbon enrichment. The fNF contained in PM1 total carbon analyzed by a US team (f TC

unknown authors

2010-01-01T23:59:59.000Z

498

On the spectrum of QCD-like theories and the conformal window  

E-Print Network (OSTI)

We report on the spectrum of the SU(3) gauge theory with twelve flavours in the fundamental representation of the gauge group. We isolate distinctive features of the hadronic phase - the one proper of QCD at zero temperature - and the so called conformal phase. The latter should emerge at sufficiently large Nf and before the loss of asymptotic freedom. In particular, we analyse available lattice data for the spectrum of Nf=12 and include a comparison with results with Nf=16; the latter theory, predicted by the perturbative beta-function to develop an IRFP and therefore be in the conformal phase, can serve as a paradigm for the study of theories in the conformal window. Our analysis suggests that the theory with twelve flavours is in the conformal window, possibly close to its lower boundary.

Albert Deuzeman; Maria Paola Lombardo; Elisabetta Pallante

2012-01-09T23:59:59.000Z

499

The Nuclear Factor-kB Pathway Regulates Cytochrome P450 3A4 Protein Stability  

SciTech Connect

We have previously observed that CYP3A4 protein levels are suppressed by inhibition of the proteasome in primary cultured hepatocytes. Because this result is opposite of what would be expected if CYP3A4 is degraded by the proteasome, it seems likely that there is another protein that is susceptible to proteasomal degradation that regulates CYP3A4 expression. In this study, we evaluate whether the nuclear factor kappa B (NF-kB) pathway is involved in that process. Our model system uses an adenovirus system to express CYP3A4 protein in HepG2 cells, which are derived from human cancer cells. Similar to results in primary hepatocytes, we found that inhibition of the proteasome with MG132 suppresses CYP3A4. Consistent with reports that proteasome inhibition suppresses the NF-kB pathway, we also observe a suppression of inhibitory kB kinase protein levels after treatment with MG132. Treatment of the HepG2 cells with NK-kB Activation Inhibitor also suppresses CYP3A4 proteins levels. In contrast, inhibition of either the proteasome or NF-kB pathways increases CYP3A4 mRNA levels. When the HepG2 cells are treated with cycloheximide, a general inhibitor of translation, the loss of CYP3A4 protein is accelerated by co-treatment with an NF-kB Activation Inhibitor. These results indicate that NF-kB activity regulates CYP3A4 protein stability and suggest that the NF-kB pathway is responsible for the decrease in CYP3A4 protein levels that results from the inhibition of proteasomal activity.

Zangar, Richard C.; Bollinger, Nikki; Verma, Seema; Karin, Norm J.; Lu, Yi

2008-06-01T23:59:59.000Z

500

Similarity Renormalization Group Evolution of Three-Nucleon Forces in a Hyperspherical Momentum Representation  

E-Print Network (OSTI)

A new framework for computing the Similarity Renormalization Group (SRG) evolution of three-nucleon forces (3NF) in momentum representation is presented. The use of antisymmetric three-particle hyperspherical momentum states ensures unitary evolutions within certain basis truncations, much like antisymmetric harmonic oscillator SRG evolutions. Additionally, in each partial wave the $T_{\\mbox{rel}}$-SRG regulator is exactly represented, similar to recent 3NF momentum representation evolutions. Unitary equivalence is demonstrated for the triton using several chiral two- plus three-nucleon interactions. This method allows for a clean visualization of the evolution of the three-nucleon forces, which manifests the SRG decoupling pattern and low-momentum universality.

Kyle A. Wendt

2013-04-04T23:59:59.000Z