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1

A lessee's guide to leasing industrial equipment  

E-Print Network [OSTI]

Costing $10, 000 with 10- Year Depreciation Term and no Scrap Value Comparison of Five Methods of Acquiring Equipment Valued at $100, 000 with a Usable Life of 10 Years and no Scrap Value 10 III. Projected Earnings on Capital Freed by Leasing 13 IV... this tax saving results in the loss of one advantage of leasing. If, in the projection of the tax savings, it is found that the tax saving is inunaterial to the lessee, then it is quite possible that leasing will prove undesirable. But to those whose...

Johnson, Jones Eugene

1959-01-01T23:59:59.000Z

2

NF 3 , the greenhouse gas missing from Kyoto  

E-Print Network [OSTI]

for NF 3 has exploded. Air Products has just announced aof 3,200 tons by 2009 (Air Products boosts NF 3 capacity inU.S. and Asia, Air Products press release of 27 November

Prather, Michael J; Hsu, Juno

2008-01-01T23:59:59.000Z

3

NF Energy Saving Corp | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF Energy Saving Corp

4

USFS Humboldt-Toiyabe National Forest | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revisionEnvReviewNonInvasiveExplorationUT-gTagusparkCalculator Jump to: navigation, searchSolomon HighCOSO

5

Haploid reporter screens aimed at identification of NF-kappaB regulators  

E-Print Network [OSTI]

Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such ...

Lee, Clarissa Ci

2014-01-01T23:59:59.000Z

6

Symmetric genuine Spherical Whittaker functions on GSp2n(F)  

E-Print Network [OSTI]

be the absolute value on F normalized in the usual way. For a ? F? ... Sp2n(F) be the semi-direct product corresponding to this action. ..... 2n(F)) eigen values.

2013-07-05T23:59:59.000Z

7

Porcine arterivirus activates the NF-{kappa}B pathway through I{kappa}B degradation  

SciTech Connect (OSTI)

Nuclear factor-kappaB (NF-{kappa}B) is a critical regulator of innate and adaptive immune function as well as cell proliferation and survival. The present study demonstrated for the first time that a virus belonging to the Arteriviridae family activates NF-{kappa}B in MARC-145 cells and alveolar macrophages. In porcine reproductive and respiratory syndrome virus (PRRSV)-infected cells, NF-{kappa}B activation was characterized by translocation of NF-{kappa}B from the cytoplasm to the nucleus, increased DNA binding activity, and NF-{kappa}B-regulated gene expression. NF-{kappa}B activation was increased as PRRSV infection progressed and in a viral dose-dependent manner. UV-inactivation of PRRSV significantly reduced the level of NF-{kappa}B activation. Degradation of I{kappa}B protein was detected late in PRRSV infection, and overexpression of the dominant negative form of I{kappa}B{alpha} (I{kappa}B{alpha}DN) significantly suppressed NF-{kappa}B activation induced by PRRSV. However, I{kappa}B{alpha}DN did not affect viral replication and viral cytopathic effect. PRRSV infection induced oxidative stress in cells by generating reactive oxygen species (ROS), and antioxidants inhibited NF-{kappa}B DNA binding activity in PRRSV-infected cells, suggesting ROS as a mechanism by which NF-{kappa}B was activated by PRRSV infection. Moreover, NF-{kappa}B-dependent expression of matrix metalloproteinase (MMP)-2 and MMP-9 was observed in PRRSV-infected cells, an observation which implies that NF-{kappa}B activation is a biologically significant aspect of PRRSV pathogenesis. The results presented here provide a basis for understanding molecular pathways of pathology and immune evasion associated with disease caused by PRRSV.

Lee, Sang-Myeong [Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States); Kleiboeker, Steven B. [Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States) and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States)]. E-mail: KleiboekerS@Missouri.edu

2005-11-10T23:59:59.000Z

8

ARM - VAP Product - aerich2nf1turn  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD) by MicrotopsProductsmwravg5mwravg Documentation Data Management FacilityProductsaerinfaerich2nf1turn

9

Hippo Pathway Phylogenetics Predicts Monoubiquitylation of Salvador and Merlin/Nf2  

E-Print Network [OSTI]

Hippo Pathway Phylogenetics Predicts Monoubiquitylation of Salvador and Merlin/Nf2 Robert G a phylogenetic approach to the Hippo pathway and predict that two of its signal transducers, Salvador and Merlin Monoubiquitylation of Salvador and Merlin/Nf2. PLoS ONE 7(12): e51599. doi:10.1371/journal.pone.0051599 Editor

Newfeld, Stuart J.

10

Smoothing single-crystalline SiC surfaces by reactive ion etching using pure NF{sub 3} and NF{sub 3}/Ar mixture gas plasmas  

SciTech Connect (OSTI)

In pure NF{sub 3} plasma, the etching rates of four kinds of single-crystalline SiC wafer etched at NF{sub 3} pressure of 2?Pa were the highest and it decreased with an increase in NF{sub 3} pressure. On the other hand, they increased with an increase in radio frequency (RF) power and were the highest at RF power of 200?W. A smooth surface was obtained on the single-crystalline 4H-SiC after reactive ion etching at NF{sub 3}/Ar gas pressure of 2?Pa and addition of Ar to NF{sub 3} plasma increased the smoothness of SiC surface. Scanning electron microscopy observation revealed that the number of pillars decreased with an increase in the Ar-concentration in the NF{sub 3}/Ar mixture gas. The roughness factor (R{sub a}) values were decreased from 51.5?nm to 25.5?nm for the As-cut SiC, from 0.25?nm to 0.20?nm for the Epi-SiC, from 5.0?nm to 0.7?nm for the Si-face mirror-polished SiC, and from 0.20?nm to 0.16?nm for the C-face mirror-polished SiC by adding 60% Ar to the NF{sub 3} gas. Both the R{sub a} values of the Epi- and the C-face mirror-polished wafer surfaces etched using the NF{sub 3}/Ar (40:60) plasma were similar to that treated with mirror polishing, so-called the Catalyst-Referred Etching (CARE) method, with which the lowest roughness of surface was obtained among the chemical mirror polishing methods. Etching duration for smoothing the single-crystalline SiC surface using its treatment was one third of that with the CARE method.

Tasaka, Akimasa, E-mail: aki-tasaka-load@yahoo.co.jp [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321, Japan and Department of Applied Chemistry, Graduate School of Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Kotaka, Yuki [Department of Applied Chemistry, Graduate School of Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Oda, Atsushi; Saito, Morihiro [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Tojo, Tetsuro [Toyo Tanso Co, Ltd., 5-7-2 Takeshima, Nishi yodogawa-ku, Osaka 555-0011 (Japan); Inaba, Minoru [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321, Japan and Department of Applied Chemistry, Graduate School of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan)

2014-09-01T23:59:59.000Z

11

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors Signal NF-B and JNK Activation and  

E-Print Network [OSTI]

factor NF- B. TRAIL-R4 can activate NF- B and protect cells from TRAIL-induced apoptosis. Here we show pathway. We also show that activa- tion of NF- B or overexpression of TRAIL-R4 does not protect TRAIL-R1, 5). Previous stud- ies suggest that TRAIL is capable of inducing apoptosis of various cancer cell

Hu, Wen-Hui

12

IKK{epsilon} modulates RSV-induced NF-{kappa}B-dependent gene transcription  

SciTech Connect (OSTI)

Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-{kappa}B (NF-{kappa}B). In this study we have investigated the role of the non canonical I{kappa}B kinase (IKK){epsilon} in modulating RSV-induced NF-{kappa}B activation. Our results show that inhibition of IKK{epsilon} activation results in significant impairment of viral-induced NF-{kappa}B-dependent gene expression, through a reduction in NF-{kappa}B transcriptional activity, without changes in nuclear translocation or DNA-binding activity. Absence of IKK{epsilon} results in a significant decrease of RSV-induced NF-{kappa}B phosphorylation on serine 536, a post-translational modification important for RSV-induced NF-{kappa}B-dependent gene expression, known to regulate NF-{kappa}B transcriptional activity without affecting nuclear translocation. This study identifies a novel mechanism by which IKK{epsilon} regulates viral-induced cellular signaling.

Bao Xiaoyong; Indukuri, Hemalatha; Liu Tianshuang; Liao Suiling [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Tian, Bing; Brasier, Allan R. [Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX (United States); Garofalo, Roberto P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States); Casola, Antonella, E-mail: ancasola@utmb.ed [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States)

2010-12-20T23:59:59.000Z

13

Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness  

E-Print Network [OSTI]

19-26. O'Dea, E. and Hoffmann, A. 2009. NF-kappaB signaling.J.D. , Levchenko, A. , and Hoffmann, A. 2007. A homeostaticS.L. , Cheng, C. , and Hoffmann, A. 2007. A temporal code

O'Dea, Ellen Louise

2010-01-01T23:59:59.000Z

14

E-Print Network 3.0 - assay nf iso Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biotechnology 5 b-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-jB Summary: ) assays (Figure 6C). Figure 4 b-Arrestin2 phosphorylation...

15

Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness  

E-Print Network [OSTI]

NF-?B-bound I?B degradation, UV irradiation results inphase of UV-induced I?B degradation, however, remain uncleardid not prevent UV-induced I?B? degradation (Bender et al.

O'Dea, Ellen Louise

2010-01-01T23:59:59.000Z

16

Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness  

E-Print Network [OSTI]

and activator of transcription TAD Trancriptional activationtranscriptional activation domain (TAD), p50 and p52 do not.Activation Domains (TAD). (B) The 5 NF-?B monomers can

O'Dea, Ellen Louise

2010-01-01T23:59:59.000Z

17

A test of first order scaling in Nf=2 QCD  

E-Print Network [OSTI]

We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

2007-09-30T23:59:59.000Z

18

Sci. Aging Knowl. Environ., Vol. 2004, Issue 34, pp. nf78, 25 August 2004 [DOI: 10.1126/sageke.2004.34.nf78  

E-Print Network [OSTI]

: They scrubbed fly eggs with alcohol, fed the animals irradiated food, and kept them in sterile containers: http://sageke.sciencemag.org/cgi/content/full/2004/34/nf78 Nasty germs in fast-food burgers can kill direction--from fare that included antibiotics to "dirty" food--extended fly life on day 2 but not on day 4

Seroude, Laurent

19

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

SciTech Connect (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

20

Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1 Machine tools : Safety : Hydraulic presses  

E-Print Network [OSTI]

Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1

Association Franaise de Normalisation. Paris

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Single-cell NF-kB dynamics reveal digital activation and analogue information processing  

E-Print Network [OSTI]

LETTERS Single-cell NF-kB dynamics reveal digital activation and analogue information processing and is a digital process at the single-cell level with fewer cells responding at lower doses. Cells also encode that reproduces both the digital and analogue dynamics as well as most gene expression profiles at all measured

Quake, Stephen R.

22

NF3: UV absorption spectrum temperature dependence and the atmospheric and climate forcing implications  

E-Print Network [OSTI]

NF3: UV absorption spectrum temperature dependence and the atmospheric and climate forcing absorption spectrum, s(l,T), was measured at 16 wavelengths between 184.95 and 250 nm at temperatures between. Including the UV absorption spectrum temperature dependence increased the stratospheric photolysis lifetime

Jackman, Charles H.

23

Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface  

SciTech Connect (OSTI)

To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H. [China Medical University, Shenyang (China)

2009-07-01T23:59:59.000Z

24

Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business  

SciTech Connect (OSTI)

This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

2011-02-01T23:59:59.000Z

25

Title 43 CFR 3202 Lessee Qualifications | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revisionEnvReviewNonInvasiveExplorationUT-gTaguspark JumpDetective: Terminology and Index Jump

26

IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching. | EMSL Bubblesstructure thebyIDEAS1,3,IDS-NF

27

FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF  

SciTech Connect (OSTI)

This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset will be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.

Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.; Livingston, James V.

2014-03-31T23:59:59.000Z

28

mm-Wave Op-Amps employing simple-Miller compensation, with OIP3/PDC ratios of 211 (10 dB NF) and 144 (6.0 dB NF) at 2 GHz  

E-Print Network [OSTI]

mm-Wave Op-Amps employing simple-Miller compensation, with OIP3/PDC ratios of 211 (10 dB NF/PDC ratio at fs = 2-3 GHz, compared to state-of-the-art. We address considerations important 1000 mW power dissipation PDC . This very high ratio of output-referred third-order-intercept power

Rodwell, Mark J. W.

29

Charmless chiral perturbation theory for N_f=2+1+1 twisted mass lattice QCD  

E-Print Network [OSTI]

The chiral Lagrangian describing the low-energy behavior of N_f=2+1+1 twisted mass lattice QCD is constructed through O(a^2). In contrast to existing results the effects of a heavy charm quark are consistently removed, leaving behind a charmless 3-flavor Lagrangian. This Lagrangian is used to compute the pion and kaon masses to one loop in a regime where the pion mass splitting is large and taken as a leading order effect. In comparison with continuum chiral perturbation theory additional chiral logarithms are present in the results. In particular, chiral logarithms involving the neutral pion mass appear. These predict rather large finite volume corrections in the kaon mass which roughly account for the finite volume effects observed in lattice data.

Oliver Baer; Ben Horz

2014-08-29T23:59:59.000Z

30

3D calculation of Tucson-Melbourne 3NF effect in triton binding energy  

E-Print Network [OSTI]

As an application of the new realistic three-dimensional (3D) formalism reported recently for three-nucleon (3N) bound states, an attempt is made to study the effect of three-nucleon forces (3NFs) in triton binding energy in a non partial wave (PW) approach. The spin-isospin dependent 3N Faddeev integral equations with the inclusion of 3NFs, which are formulated as function of vector Jacobi momenta, specifically the magnitudes of the momenta and the angle between them, are solved with Bonn-B and Tucson-Melbourne NN and 3N forces in operator forms which can be incorporated in our 3D formalism. The comparison with numerical results in both, novel 3D and standard PW schemes, shows that non PW calculations avoid the very involved angular momentum algebra occurring for the permutations and transformations and it is more efficient and less cumbersome for considering the 3NF.

M. R. Hadizadeh; L. Tomio; S. Bayegan

2010-03-24T23:59:59.000Z

31

Kaon semileptonic vector form factor with $N_f=2+1+1$ Twisted Mass fermions  

E-Print Network [OSTI]

We investigate the vector form factor relevant for the $K_{\\ell 3}$ semileptonic decay using maximally twisted-mass fermions with 4 dynamical flavours ($N_f=2+1+1$). Our simulations feature pion masses ranging from $210$ MeV to approximately $450$ MeV and lattice spacing values as small as $0.06$fm. Our main result for the vector form factor at zero 4-momentum transfer is $f_+(0)=0.9683(65)$ where the uncertainty is both statistical and systematic. By combining our result with the experimental value of $f_+(0)|V_{us}|$ we obtain $|V_{us}|=0.2234(16)$, which satisfies the unitarity constraint of the Standard Model at the permille level.

Nuria Carrasco; Paolo Lami; Vittorio Lubicz; Eleonora Picca; Lorenzo Riggio; Silvano Simula; Cecilia Tarantino

2014-10-27T23:59:59.000Z

32

Ascorbic acid suppresses endotoxemia and NF-?B signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach  

SciTech Connect (OSTI)

Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-?B activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKK? and the protein expressions of phospho-I?B?, NF-?B, TNF-?, TGF-?{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers ?-SMA, ?{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-?B activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKK?, which decreased the activation of NF-?B and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. Ascorbic acid reduces endotoxemia, NF-?B activation and proinflammatory cytokines. AA's action is by inhibition of SIBO, IKK? and alteration of intestinal permeability. This might have led to suppression of HSCs activation and liver fibrosis.

Abhilash, P.A.; Harikrishnan, R.; Indira, M., E-mail: indiramadambath@gmail.com

2014-01-15T23:59:59.000Z

33

NF-kB activity-dependent P-selectin involved in ox-LDL-induced foam cell formation in U937 cell  

SciTech Connect (OSTI)

Highlights: {yields} Ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. {yields} Ox-LDL induced expression of P-selectin through degradation of IkBa and augment of NF-kB activity and protein level during macrophage-derived foam cell formation. {yields} P-selectin and NF-kB may be identified as pivotal regulators of ox-LDL-induced foam cell formation. {yields} Therapy based on the inhibition of P-selectin and NF-kB may complement conventional treatments to prevent atherosclerosis. -- Abstract: Oxidized low-density lipoprotein (ox-LDL) plays a critical role in regulation of atherosclerosis. However, little is known about the role of Nuclear factor kB (NF-kB) activity-dependent P-selectin in ox-LDL-induced foam cell formation during atherosclerosis. In this study, we first investigated ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. Treatment of U937 cells with ox-LDL increased lipid accumulation as well as intracellular cholesterol content. Next, a comparative analysis of gene expression profiling using cDNA microarray and Real-time-PCR indicated that ox-LDL exposure induced, in three treated groups, an extremely marked increase in the mRNA level of P-selectin. Protein levels of P-selectin and its upstream regulators IkBa and NF-kB showed that NF-kB pathway is involved in the ox-LDL-induced foam cell formation. Finally, overexpression of NF-kB significantly accelerated, whereas, inhibition of NF-kB with siRNA remarkably attenuated ox-LDL-induced macrophage-derived foam cell formation. It was concluded that the activity of NF-kB is augmented during macrophage-derived foam cell formation. Activation of NF-kB increased, whereas, inhibition of NF-kB decreased ox-LDL-induced P-selectin expression and lipid accumulation in macrophages, suggesting ox-LDL induced expression of P-selectin through degradation of IkBa and activation of NF-kB in the regulation of foam cell formation.

Wang, Yi, E-mail: wangyi2004a@126.com [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China); Wang, Xiang; Sun, Minghui; Zhang, Zhenyu; Cao, Heng; Chen, Xiaoqing [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)

2011-08-05T23:59:59.000Z

34

Thermal Reactions of Uranium Metal, UO2, U3O8, UF4, and UO2F2 with NF3 to Produce UF6  

SciTech Connect (OSTI)

he objective of this paper is to demonstrate that NF3 fluorinates uranium metal, UO2, UF4, UO3, U3O8, and UO2F22H2O to produce the volatile UF6 at temperatures between 100 and 500?C. Thermogravimetric reaction profiles are described that reflect changes in the uranium oxidation state and discrete chemical speciation. Differences in the onset temperatures for each system indicate that NF3-substrate interactions are important for the temperature at which NF3 reacts: U metal > UO3 > UO2 > UO2F2 > UF4 and in fact may indicate different fluorination mechanisms for these various substrates. These studies demonstrate that NF3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in oft-proposed actinide volatility reprocessing.

McNamara, Bruce K.; Scheele, Randall D.; Kozelisky, Anne E.; Edwards, Matthew K.

2009-11-01T23:59:59.000Z

35

Differential Effects of ?-catenin and NF-?B Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection  

E-Print Network [OSTI]

Both ?-catenin and NF-?B have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium (CR)-induced colonic crypt hyper-proliferation and hyperplasia. ...

Chandrakesan, Parthasarathy; Jakkula, Laxmi Uma Maheswar Rao; Ahmed, Ishfaq; Roy, Badal; Anant, Shrikant; Umar, Shahid

2013-11-21T23:59:59.000Z

36

Curcumin Regulates Low-Linear Energy Transfer {gamma}-Radiation-Induced NF{kappa}B-Dependent Telomerase Activity in Human Neuroblastoma Cells  

SciTech Connect (OSTI)

Purpose: We recently reported that curcumin attenuates ionizing radiation (IR)-induced survival signaling and proliferation in human neuroblastoma cells. Also, in the endothelial system, we have demonstrated that NF{kappa}B regulates IR-induced telomerase activity (TA). Accordingly, we investigated the effect of curcumin in inhibiting IR-induced NF{kappa}B-dependent hTERT transcription, TA, and cell survival in neuroblastoma cells. Methods and Materials: SK-N-MC or SH-SY5Y cells exposed to IR and treated with curcumin (10-100 nM) with or without IR were harvested after 1 h through 24 h. NF{kappa}B-dependent regulation was investigated either by luciferase reporter assays using pNF{kappa}B-, pGL3-354-, pGL3-347-, or pUSE-I{kappa}B{alpha}-Luc, p50/p65, or RelA siRNA-transfected cells. NF{kappa}B activity was analyzed using an electrophoretic mobility shift assay and hTERT expression using the quantitative polymerase chain reaction. TA was determined using the telomerase repeat amplification protocol assay and cell survival using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltertrazolium bromide and clonogenic assay. Results: Curcumin profoundly inhibited IR-induced NF{kappa}B. Consequently, curcumin significantly inhibited IR-induced TA and hTERT mRNA at all points investigated. Furthermore, IR-induced TA is regulated at the transcriptional level by triggering telomerase reverse transcriptase (TERT) promoter activation. Moreover, NF{kappa}B becomes functionally activated after IR and mediates TA upregulation by binding to the {kappa}B-binding region in the promoter region of the TERT gene. Consistently, elimination of the NF{kappa}B-recognition site on the telomerase promoter or inhibition of NF{kappa}B by the I{kappa}B{alpha} mutant compromises IR-induced telomerase promoter activation. Significantly, curcumin inhibited IR-induced TERT transcription. Consequently, curcumin inhibited hTERT mRNA and TA in NF{kappa}B overexpressed cells. Furthermore, curcumin enhanced the IR-induced inhibition of cell survival. Conclusions: These results strongly suggest that curcumin inhibits IR-induced TA in an NF{kappa}B dependent manner in human neuroblastoma cells.

Aravindan, Natarajan, E-mail: naravind@ouhsc.ed [Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Veeraraghavan, Jamunarani; Madhusoodhanan, Rakhesh; Herman, Terence S. [Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Natarajan, Mohan [Department of Otolaryngology, Head and Neck Surgery, University of Texas Health Sciences Center at San Antonio, San Antonio, TX (United States)

2011-03-15T23:59:59.000Z

37

Sulforaphane protects against cytokine- and streptozotocin-induced {beta}-cell damage by suppressing the NF-{kappa}B pathway  

SciTech Connect (OSTI)

Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes. Treatment of RINm5F insulinoma cells with SFN increases Nrf2 nuclear translocation and expression of phase 2 enzymes. In this study, we investigated whether the activation of Nrf2 by SFN treatment or ectopic overexpression of Nrf2 inhibited cytokine-induced {beta}-cell damage. Treatment of RIN cells with IL-1{beta} and IFN-{gamma} induced {beta}-cell damage through a NF-{kappa}B-dependent signaling pathway. Activation of Nrf2 by treatment with SFN and induction of Nrf2 overexpression by transfection with Nrf2 prevented cytokine toxicity. The mechanism by which Nrf2 activation inhibited NF-{kappa}B-dependent cell death signals appeared to involve the reduction of oxidative stress, as demonstrated by the inhibition of cytokine-induced H{sub 2}O{sub 2} production. The protective effect of SFN was further demonstrated by the restoration of normal insulin secreting responses to glucose in cytokine-treated rat pancreatic islets. Furthermore, pretreatment with SFN blocked the development of type 1 diabetes in streptozotocin-treated mice.

Song, Mi-Young; Kim, Eun-Kyung [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Moon, Woo-Sung [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Kim, Hyung-Jin; So, Hong-Seob; Park, Raekil [Vestibulocochlear System Research Center, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of); Kwon, Kang-Beom [Department of Physiology, School of Oriental Medicine, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of); Vestibulocochlear System Research Center, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of)], E-mail: desson@wonkwang.ac.kr; Park, Byung-Hyun [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of)], E-mail: bhpark@chonbuk.ac.kr

2009-02-15T23:59:59.000Z

38

Etching of UO{sub 2} in NF{sub 3} RF Plasma Glow Discharge  

SciTech Connect (OSTI)

A series of room temperature, low pressure (10.8 to 40 Pa), low power (25 to 210 W) RF plasma glow discharge experiments with UO{sub 2} were conducted to demonstrate that plasma treatment is a viable method for decontaminating UO{sub 2} from stainless steel substrates. Experiments were conducted using NF{sub 3} gas to decontaminate depleted uranium dioxide from stainless-steel substrates. Depleted UO{sub 2} samples each containing 129.4 Bq were prepared from 100 microliter solutions of uranyl nitrate hexahydrate solution. The amorphous UO{sub 2} in the samples had a relatively low density of 4.8 gm/cm{sub 3}. Counting of the depleted UO{sub 2} on the substrate following plasma immersion was performed using liquid scintillation counting with alpha/beta discrimination due to the presence of confounding beta emitting daughter products, {sup 234}Th and {sup 234}Pa. The alpha emission peak from each sample was integrated using a gaussian and first order polynomial fit to improve quantification. The uncertainties in the experimental measurement of the etched material were estimated at about {+-} 2%. Results demonstrated that UO{sub 2} can be completely removed from stainless-steel substrates after several minutes processing at under 200 W. At 180 W and 32.7 Pa gas pressure, over 99% of all UO{sub 2} in the samples was removed in just 17 minutes. The initial etch rate in the experiments ranged from 0.2 to 7.4 {micro}m/min. Etching increased with the plasma absorbed power and feed gas pressure in the range of 10.8 to 40 Pa. A different pressure effect on UO{sub 2} etching was also noted below 50 W in which etching increased up to a maximum pressure, {approximately}23 Pa, then decreased with further increases in pressure.

John M. Veilleux

1999-08-01T23:59:59.000Z

39

NF-{kappa}B signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer EGFR-mutant cells in 3D culture resist EGFR inhibition compared with suspended cells. Black-Right-Pointing-Pointer Degradation of I{kappa}B and activation of NF-{kappa}B are observed in 3D-cultured cells. Black-Right-Pointing-Pointer Inhibiting NF-{kappa}B enhances the efficacy of the EGFR inhibitor in 3D-cultured cells. -- Abstract: Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cells in suspension undergo apoptosis to a greater extent than adherent cells in a monolayer when EGFR autophosphorylation is inhibited by EGFR tyrosine kinase inhibitors (TKIs). This suggests that cell adhesion to a culture dish may activate an anti-apoptotic signaling pathway other than the EGFR pathway. Since the microenvironment of cells cultured in a monolayer are substantially different to that of cells existing in three-dimension (3D) in vivo, we assessed whether two EGFR-mutant lung adenocarcinoma cell lines, HCC827 and H1975, were more resistant to EGFR TKI-induced apoptosis when cultured in a 3D extracellular matrix (ECM) as compared with in suspension. The ECM-adherent EGFR-mutant cells in 3D were significantly less sensitive to treatment with WZ4002, an EGFR TKI, than the suspended cells. Further, a marked degradation of I{kappa}B{alpha}, the inhibitor of nuclear factor (NF)-{kappa}B, was observed only in the 3D-cultured cells, leading to an increase in the activation of NF-{kappa}B. Moreover, the inhibition of NF-{kappa}B with pharmacological inhibitors enhanced EGFR TKI-induced apoptosis in 3D-cultured EGFR-mutant cells. These results suggest that inhibition of NF-{kappa}B signaling would render ECM-adherent EGFR-mutant lung adenocarcinoma cells in vivo more susceptible to EGFR TKI-induced cell death.

Sakuma, Yuji, E-mail: ysakuma@gancen.asahi.yokohama.jp [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)] [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan); Yamazaki, Yukiko; Nakamura, Yoshiyasu; Yoshihara, Mitsuyo; Matsukuma, Shoichi; Koizume, Shiro; Miyagi, Yohei [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)] [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)

2012-07-13T23:59:59.000Z

40

Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-{kappa}B  

SciTech Connect (OSTI)

Phenobarbital (PB) is a nongenotoxic tumor promoter in the liver. One mechanism by which PB may exert its tumor promoting activity is by inducing oxidative stress. We previously found that PB administration increased hepatic NF-{kappa}B DNA binding activity. In this study we examined the hypothesis that the effects of PB on cell proliferation and apoptosis are dependent on NF-{kappa}B. We used a mouse model that is deficient in the p50 subunit of NF-{kappa}B; previous studies had found that p50-/- mice were less sensitive to the induction of hepatic cell proliferation by PCBs or peroxisome proliferators. Mice (p50-/- and wild-type B6129) were fed a control diet or one containing 0.05% PB for 3, 10 or 34 days. At the end of the experiment, the mice were euthanized and livers removed and processed. PB increased cell proliferation at 3 and 10 days (but not at 34 days), but the deletion of the NF-{kappa}B p50 subunit did not inhibit these increases. p50-/- Mice had higher cell proliferation at the 3 day (only in mice fed PB) and 34-day timepoints. PB decreased hepatocyte apoptosis after 3 days, slightly decreased it after 10 days, and did not affect it after 34 days. The deletion of the NF-{kappa}B p50 subunit did not influence PB's effect on apoptosis. In p50-/- mice, apoptosis was increased after 3 or 10 days compared to wild-type mice, but no effect was seen after 34 days. The hepatic expression of the NF-{kappa}B-regulated gene TNF-{alpha} correlated more with the hepatic cell proliferation data than with hepatic apoptosis, and was not decreased by the deletion of the p50 subunit. These findings show that the p50 subunit of NF-{kappa}B is not required for the alteration of hepatocyte proliferation or apoptosis by PB up to 34 days after its administration.

Tharappel, Job C. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Spear, Brett T. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States); Glauert, Howard P. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States)], E-mail: hglauert@uky.edu

2008-02-01T23:59:59.000Z

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41

Update on a short-distance D^0-meson mixing calculation with $N_f=2+1$ flavors  

E-Print Network [OSTI]

We present an update on our calculation of the short-distance $D^0$-meson mixing hadronic matrix elements. The analysis is performed on the MILC collaboration's $N_f=2+1$ asqtad configurations. We use asqtad light valence quarks and the Sheikoleslami-Wohlert action with the Fermilab interpretation for the valence charm quark. SU(3), partially quenched, rooted, staggered heavy-meson chiral perturbation theory is used to extrapolate to the chiral-continuum limit. Systematic errors arising from the chiral-continuum extrapolation, heavy-quark discretization, and quark-mass uncertainties are folded into the statistical errors from the chiral-continuum fits with methods of Bayesian inference. A preliminary error budget for all five operators is presented.

C. C. Chang; C. Bernard; C. M. Bouchard; A. X. El-Khadra; E. D. Freeland; E. Gmiz; A. S. Kronfeld; J. Laiho; R. S. Van de Water

2014-12-13T23:59:59.000Z

42

Magnetic susceptibility and equation of state of N_f = 2+1 QCD with physical quark masses  

E-Print Network [OSTI]

We determine the free energy of strongly interacting matter as a function of an applied constant and uniform magnetic field. We consider N_f = 2+1 QCD with physical quark masses, discretized on a lattice by stout improved staggered fermions and a tree level improved Symanzik pure gauge action, and explore three different lattice spacings. For magnetic fields of the order of those produced in non-central heavy ion collisions (eB ~ 0.1 GeV^2) strongly interacting matter behaves like a medium with a linear response, and is paramagnetic both above and below the deconfinement transition, with a susceptibility which steeply rises in the deconfined phase. We compute the equation of state, showing that the relative increase in the pressure due to the magnetic field gets larger around the transition, and of the order of 10 % for eB ~ 0.1 GeV^2.

Claudio Bonati; Massimo D'Elia; Marco Mariti; Francesco Negro; Francesco Sanfilippo

2014-05-13T23:59:59.000Z

43

Spontaneous transition of core radial electric field driven by magnetic islands in the H-1NF heliac  

SciTech Connect (OSTI)

This paper reports an experimental observation of spontaneous transition of the core radial electric field to a large positive value (E(r) similar to 5 kV m(-1)), with a strong electric-field shear (similar to 700 kV m(-2)) in a low temperature (T(e) similar to 10 eV) radio frequency generated argon plasma in the H-1NF heliac stellarator. The transition, which seems to be driven by a spontaneous excitation of m = 2 magnetic islands near the core, is associated with a localized increase in the plasma density and excitation of coherent low frequency (similar to 3 kHz) oscillations possibly due to unstable E(r) shear driven modes. Evidence suggests development of the core electron-root scenario, which previously has been observed only at high temperature electron cyclotron heated plasmas.

Kumar, S. T. A. [University of Wisconsin, Madison; Blackwell, B. D. [Australian National University, Canberra, Australia; Howard, J. [Australian National University, Canberra, Australia; Harris, J. H. [Oak Ridge National Laboratory (ORNL)

2011-01-01T23:59:59.000Z

44

DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process.  

E-Print Network [OSTI]

1 DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process. Mori K.1, 2, * , Le Goff B. 1, 2 , Charrier C. 1, 2 , Battaglia S;40(4):981-90" DOI : 10.1016/j.bone.2006.11.006 #12;2 Abstract Prostate cancer metastases to bone are observed

Boyer, Edmond

45

YANMAR NFD9-M, NF19-SK,--p,A"R--,, OEy, Ad,Zg--p,AOESw`'u,,,"rKX', PM,`',,D  

E-Print Network [OSTI]

Flying Wheel Hydrolic Dynamometer Exhaust Gas Pipe DO Tank Suction Pipe Measuring Point Specification,ð`ª'è,µ,½·D Z? OE± Ds Ds Ds(nm) Da Simulated Form of Aggregated PM in Exhaust Gas --±Zq on Diesel Engine 25 50 75 100 0 10 20 0 200 400 600 AirRatio Exp. results on NF-19SK Diesel Eng. Fuel oil

Ishii, Hitoshi

46

Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-{kappa}B translocation and ROS production in synoviocytes  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Moderate extracellular acidification regulates intracellular Ca{sup 2+} mobilization. Black-Right-Pointing-Pointer Moderate acidification activates NF-{kappa}B nuclear translocation in synoviocytes. Black-Right-Pointing-Pointer Moderate acidification depresses the ROS production induced by capsaicin. Black-Right-Pointing-Pointer Moderate acidification inhibits capsaicin-caused synoviocyte death. -- Abstract: We previously show the expression of transient receptor potential vanilloid 1 (TRPV1) in primary synoviocytes from collagen-induced arthritis (CIA) rats. Capsaicin and lowered extracellular pH from 7.4 to 5.5 induce cell death through TRPV1-mediated Ca{sup 2+} entry and reactive oxygen species (ROS) production. However, under the pathological condition in rheumatoid arthritis, the synovial fluid is acidified to a moderate level (about pH 6.8). In the present study, we examined the effects of pH 6.8 on the TRPV1-mediated cell death. Our finding is different or even opposite from what was observed at pH 5.5. We found that the moderate extracellular acidification (from pH 7.4 to 6.8) inhibited the capsaicin-induced Ca{sup 2+} entry through attenuating the activity of TRPV1. In the mean time, it triggered a phospholipse C (PLC)-related Ca{sup 2+} release from intracellular stores. The nuclear translocation of NF-{kappa}B was found at pH 6.8, and this also depends on PLC activation. Moreover, the capsaicin-evoked massive ROS production and cell death were depressed at pH 6.8, both of which are dependent on the activation of PLC and NF-{kappa}B. Taken together, these results suggested that the moderate extracellular acidification inhibited the capsaicin-induced synoviocyte death through regulating Ca{sup 2+} mobilization, activating NF-{kappa}B nuclear translocation and depressing ROS production.

Hu, Fen; Yang, Shuang; Zhao, Dan; Zhu, Shuyan; Wang, Yuxiang [Department of Biophysics, School of Physics and Key Laboratory of Bioactive Materials of Education Ministry, Nankai University, Tianjin 300071 (China)] [Department of Biophysics, School of Physics and Key Laboratory of Bioactive Materials of Education Ministry, Nankai University, Tianjin 300071 (China); Li, Junying, E-mail: jyli04@nankai.edu.cn [Department of Biophysics, School of Physics and Key Laboratory of Bioactive Materials of Education Ministry, Nankai University, Tianjin 300071 (China)] [Department of Biophysics, School of Physics and Key Laboratory of Bioactive Materials of Education Ministry, Nankai University, Tianjin 300071 (China)

2012-07-20T23:59:59.000Z

47

Carbachol ameliorates lipopolysaccharide-induced intestinal epithelial tight junction damage by down-regulating NF-{kappa}{beta} and myosin light-chain kinase pathways  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Carbachol reduced the lipopolysaccharide-induced intestinal barrier breakdown. Black-Right-Pointing-Pointer Carbachol ameliorated the lipopolysaccharide-induced ileal tight junction damage. Black-Right-Pointing-Pointer Carbachol prevented the LPS-induced NF-{kappa}{beta} and myosin light-chain kinase activation. Black-Right-Pointing-Pointer Carbachol exerted its beneficial effects in an {alpha}7 nicotinic receptor-dependent manner. -- Abstract: Carbachol is a cholinergic agonist that protects the intestines after trauma or burn injury. The present study determines the beneficial effects of carbachol and the mechanisms by which it ameliorates the lipopolysaccharide (LPS)-induced intestinal barrier breakdown. Rats were injected intraperitoneally with 10 mg/kg LPS. Results showed that the gut barrier permeability was reduced, the ultrastructural disruption of tight junctions (TJs) was prevented, the redistribution of zonula occludens-1 and claudin-2 proteins was partially reversed, and the nuclear factor-kappa beta (NF-{kappa}{beta}) and myosin light-chain kinase (MLCK) activation in the intestinal epithelium were suppressed after carbachol administration in LPS-exposed rats. Pretreatment with the {alpha}7 nicotinic acetylcholine receptor ({alpha}7nAchR) antagonist {alpha}-bungarotoxin blocked the protective action of carbachol. These results suggested that carbachol treatment can protect LPS-induced intestinal barrier dysfunction. Carbachol exerts its beneficial effect on the amelioration of the TJ damage by inhibiting the NF-{kappa}{beta} and MLCK pathways in an {alpha}7nAchR-dependent manner.

Zhang, Ying [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China); Li, Jianguo, E-mail: 2010lijianguo@sina.cn [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)

2012-11-16T23:59:59.000Z

48

Broken Valence Chiral Symmetry and Chiral Polarization of Dirac Spectrum in N$_f$=12 QCD at Small Quark Mass  

E-Print Network [OSTI]

The validity of recently proposed equivalence between valence spontaneous chiral symmetry breaking (vSChSB) and chiral polarization of low energy Dirac spectrum (ChP) in SU(3) gauge theory, is examined for the case of twelve mass-degenerate fundamental quark flavors. We find that the vSChSB-ChP correspondence holds for regularized systems studied. Moreover, our results suggest that vSChSB occurs in two qualitatively different circumstances: there is a quark mass $m_c$ such that for $m > m_c$ the mode condensing Dirac spectrum exhibits standard monotonically increasing density, while for $m_{ch} < m < m_c$ the peak around zero separates from the bulk of the spectrum, with density showing a pronounced depletion at intermediate scales. Valence chiral symmetry restoration may occur at yet smaller masses $m < m_{ch}$, but this has not yet been seen by overlap valence probe, leaving the $m_{ch}=0$ possibility open. The latter option could place massless N$_f$=12 theory outside of conformal window. Anomalous behavior of overlap Dirac spectrum for $m_{ch} < m < m_c$ is qualitatively similar to one observed previously in zero and few-flavor theories as an effect of thermal agitation.

Andrei Alexandru; Ivan Horvth

2014-12-04T23:59:59.000Z

49

Up, down, strange and charm quark masses with Nf = 2+1+1 twisted mass lattice QCD  

E-Print Network [OSTI]

We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210 - 450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI-MOM method. The results for the quark masses converted to the bar{MS} scheme are: mud(2 GeV) = 3.70(17) MeV, ms(2 GeV) = 99.6(4.3) MeV and mc(mc) = 1.348(46) GeV. We obtain also the quark mass ratios ms/mud = 26.66(32) and mc/ms = 11.62(16). By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate mu/md = 0.470(56), leading to mu = 2.36(24) MeV and md = 5.03(26) MeV.

N. Carrasco; A. Deuzeman; P. Dimopoulos; R. Frezzotti; V. Gimenez; G. Herdoiza; P. Lami; V. Lubicz; D. Palao; E. Picca; S. Recker; L. Riggio; G. C. Rossi; F. Sanfilippo; L. Scorzato; S. Simula; C. Tarantino; C. Urbach; U. Wenger

2014-08-21T23:59:59.000Z

50

Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: Probably an indirect action via the regulation of NF?B/FasL circuitry  

SciTech Connect (OSTI)

Highlights: MTA1 expression is upregulated in SCs upon MEHP treatment. Knockdown of MTA1 in SCs impairs the MEHP-induced NF?B signaling activation. Knockdown of MTA1 inhibits recruitment of NF?B onto FasL promoter in MEHP-treated SCs. -- Abstract: The Fas/FasL signaling pathway, controlled by nuclear factor-?B (NF?B) at the transcriptional level, is critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell (SC) injury, but the exact regulation mechanism remain unknown. Here, we discovered that expression level of Metastasis associated protein 1 (MTA1), a component of the Mi-2/nucleosome remodeling and deacetylase complex, was upregulated in SCs during the early recovery after MEHP exposure. This expression change was in line with the dynamic changes in germ cell apoptosis in response to MEHP treatment. Furthermore, a knockdown of MTA1 by RNAi in SCs was found to impair the MEHP-induced early activation of NF?B pathway and abolish the recruitment of NF?B onto FasL promoter, which consequently diminished the MEHP-triggered FasL induction. Considering that Fas/FasL is a well characterized apoptosis initiating signaling during SCs injury, our results point to a potential switch on effect of MTA1, which may govern the activation of NF?B/FasL cascade in MEHP-insulted SCs. Overall, the MTA1/NF?B/FasL circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after SCs injury.

Chen, Shiwei [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China)] [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China); Dong, Yushu [Department of Neurosurgery, 463rd Hospital of PLA, Shenyang 110042 (China)] [Department of Neurosurgery, 463rd Hospital of PLA, Shenyang 110042 (China); Xu, Chun; Jiang, Liming; Chen, Yongjie; Jiang, Cheng [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China)] [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China); Hou, Wugang, E-mail: gangwuhou@163.com [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xian 710032 (China)] [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xian 710032 (China); Li, Wei, E-mail: liweipepeyato@163.com [Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xian 710032 (China)] [Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xian 710032 (China)

2013-11-01T23:59:59.000Z

51

Impaired NFAT and NF?B activation are involved in suppression of CD40 ligand expression by ?{sup 9}-tetrahydrocannabinol in human CD4{sup +} T cells  

SciTech Connect (OSTI)

We have previously reported that ?{sup 9}-tetrahydrocannabinol (?{sup 9}-THC), the main psychoactive cannabinoid in marijuana, suppresses CD40 ligand (CD40L) expression by activated mouse CD4{sup +} T cells. CD40L is involved in pathogenesis of many autoimmune and inflammatory diseases. In the present study, we investigated the molecular mechanism of ?{sup 9}-THC-mediated suppression of CD40L expression using peripheral blood human T cells. Pretreatment with ?{sup 9}-THC attenuated CD40L expression in human CD4{sup +} T cells activated by anti-CD3/CD28 at both the protein and mRNA level, as determined by flow cytometry and quantitative real-time PCR, respectively. Electrophoretic mobility shift assays revealed that ?{sup 9}-THC suppressed the DNA-binding activity of both NFAT and NF?B to their respective response elements within the CD40L promoter. An assessment of the effect of ?{sup 9}-THC on proximal T cell-receptor (TCR) signaling induced by anti-CD3/CD28 showed significant impairment in the rise of intracellular calcium, but no significant effect on the phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?. Collectively, these findings identify perturbation of the calcium-NFAT and NF?B signaling cascade as a key mechanistic event by which ?{sup 9}-THC suppresses human T cell function. - Highlights: ?{sup 9}-THC attenuated CD40L expression in activated human CD4+ T cells. ?{sup 9}-THC suppressed DNA-binding activity of NFAT and NF?B. ?{sup 9}-THC impaired elevation of intracellular Ca2+. ?{sup 9}-THC did not affect phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?.

Ngaotepprutaram, Thitirat [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Kaplan, Barbara L.F. [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Neuroscience Program, Michigan State University (United States); Kaminski, Norbert E., E-mail: kamins11@msu.edu [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States)

2013-11-15T23:59:59.000Z

52

Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-?B and MAPK pathways  

SciTech Connect (OSTI)

Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiovascular diseases. Therefore, AR inhibition seems to be a useful strategy for anti-inflammation therapy. In the central nervous system (CNS), microglial over-activation is considered to be a central event in neuroinflammation. However, the effects of AR inhibition in CNS inflammation and its underlying mechanism of action remain unknown. In the present study, we found that FMHM (a naturally derived AR inhibitor from the roots of Polygala tricornis Gagnep.) showed potent anti-neuroinflammatory effects in vivo and in vitro by inhibiting microglial activation and expression of inflammatory mediators. Mechanistic studies showed that FMHM suppressed the activity of AR-dependent phospholipase C/protein kinase C signaling, which further resulted in downstream inactivation of the I?B kinase/I?B/nuclear factor-kappa B (NF-?B) inflammatory pathway. Therefore, AR inhibition-dependent NF-?B inactivation negatively regulated the transcription and expression of various inflammatory genes. AR inhibition by FMHM exerted neuroprotective effects in lipopolysaccharide-induced neuronmicroglia co-cultures. These findings suggested that AR is a potential target for neuroinflammation inhibition and that FMHM could be an effective agent for treating or preventing neuroinflammatory diseases. - Highlights: FMHM is a natural-derived aldose reductase (AR) inhibitor. FMHM inhibits various neuroinflammatory mediator productions in vitro and in vivo. FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent NF-?B pathway. FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent MAPK pathway. FMHM protects neurons against inflammatory injury in microglia-neuron co-cultures.

Zeng, Ke-Wu [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Li, Jun [Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China); Dong, Xin; Wang, Ying-Hong; Ma, Zhi-Zhong; Jiang, Yong; Jin, Hong-Wei [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Tu, Peng-Fei, E-mail: pengfeitu@vip.163.com [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China)

2013-11-15T23:59:59.000Z

53

OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting AktNF-?B and MAPK signaling pathways  

SciTech Connect (OSTI)

Since the introduction of angiogenesis as a useful target for cancer therapy, few agents have been approved for clinical use due to the rapid development of resistance. This problem can be minimized by simultaneous targeting of multiple angiogenesis signaling pathways, a potential strategy in cancer management known as polypharmacology. The current study aimed at exploring the anti-angiogenic activity of OSU-A9, an indole-3-carbinol-derived pleotropic agent that targets mainly Aktnuclear factor-kappa B (NF-?B) signaling which regulates many key players of angiogenesis such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Human umbilical vein endothelial cells (HUVECs) were used to study the in vitro anti-angiogenic effect of OSU-A9 on several key steps of angiogenesis. Results showed that OSU-A9 effectively inhibited cell proliferation and induced apoptosis and cell cycle arrest in HUVECs. Besides, OSU-A9 inhibited angiogenesis as evidenced by abrogation of migration/invasion and Matrigel tube formation in HUVECs and attenuation of the in vivo neovascularization in the chicken chorioallantoic membrane assay. Mechanistically, Western blot, RT-PCR and ELISA analyses showed the ability of OSU-A9 to inhibit MMP-2 production and VEGF expression induced by hypoxia or phorbol-12-myristyl-13-acetate. Furthermore, dual inhibition of AktNF-?B and mitogen-activated protein kinase (MAPK) signaling, the key regulators of angiogenesis, was observed. Together, the current study highlights evidences for the promising anti-angiogenic activity of OSU-A9, at least in part through the inhibition of AktNF-?B and MAPK signaling and their consequent inhibition of VEGF and MMP-2. These findings support OSU-A9's clinical promise as a component of anticancer therapy. - Highlights: The antiangiogenic activity of OSU-A9 in HUVECs was explored. OSU-A9 inhibited HUVECs proliferation, migration, invasion and tube formation. OSU-A9 targeted signaling pathways mediated by Akt-NF-kB, VEGF, and MMP-2. The anti-angiogenic activity of OSU-A9 supports its clinical promise.

Omar, Hany A. [Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210 (United States); Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Arafa, El-Shaimaa A. [Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Salama, Samir A. [Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11511 (Egypt); Arab, Hany H. [Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562 (Egypt); Wu, Chieh-Hsi, E-mail: chhswu@mail.cmu.edu.tw [School of Pharmacy, China Medical University, Taichung 40402, Taiwan (China); Weng, Jing-Ru, E-mail: columnster@gmail.com [Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan (China)

2013-11-01T23:59:59.000Z

54

The NSVZ beta-function and the Schwinger-Dyson equations for N=1 SQED with N_f flavors, regularized by higher derivatives  

E-Print Network [OSTI]

The effective diagram technique based on the Schwinger-Dyson equations is constructed for N=1 SQED with N_f flavors, regularized by higher derivatives. Using these effective diagrams, it is possible to derive the exact NSVZ relation between the beta-function and the anomalous dimension of the matter superfields exactly in all loops, if the renormalization group functions are defined in terms of the bare coupling constant. In particular, we verify that all integrals which give the beta-function defined in terms of the bare coupling constant are integrals of double total derivatives and prove some identities relating Green functions.

K. V. Stepanyantz

2014-06-08T23:59:59.000Z

55

Matematikcentrum Matematik NF  

E-Print Network [OSTI]

¨anda med kaninerna? Vi f¨oruts¨atter att den logistiska tillv¨axtlagen g¨aller. 8. Datafreaken Sune har bara om man tycker det ¨ar bra. Erfarenhetsm¨assigt vet Sune att nedladdningen av programmet ¨ar snitt 0,3 % av dessa f¨or programmet, som kostar 99 kronor. Sune tar nu semes- ter och °aker en m

Gudmundsson, Sigmundur

56

NF_Eder_2013  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Opticalhttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gifAEnergy2014 Solid Oxide NEVIS-passingNEWS3

57

Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-?B in 4-nitroquinoline 1-oxide-induced murine oral cancer model  

SciTech Connect (OSTI)

The purpose of this study was to identify the genes induced early in murine oral carcinogenesis. Murine tongue tumors induced by the carcinogen, 4-nitroquinoline 1-oxide (4-NQO), and paired non-tumor tissues were subjected to microarray analysis. Hierarchical clustering of upregulated genes in the tumor tissues revealed an association of induced genes with inflammation. Cytokines/cytokine receptors induced early were subsequently identified, clearly indicating their involvement in oral carcinogenesis. Hierarchical clustering also showed that cytokine-mediated inflammation was possibly linked with Mapk6. Cox2 exhibited the greatest extent (918 fold) of induction in the microarray data, and its early induction was observed in a 2 h painting experiment by RT-PCR. MetaCore analysis showed that overexpressed Cox2 may interact with p53 and transcriptionally inhibit expression of several downstream genes. A painting experiment in transgenic mice also demonstrated that NF-?B activates early independently of Cox2 induction. MetaCore analysis revealed the most striking metabolic alterations in tumor tissues, especially in lipid metabolism resulting from the reduction of Ppar? and Rxrg. Reduced expression of Mapk12 was noted, and MetaCore analysis established its relationship with decreased efficiency of Ppar? phosphorylation. In conclusion, in addition to cytokines/cytokine receptors, the early induction of Cox2 and NF-?B activation is involved in murine oral carcinogenesis.

Liu, Yu-Ching [Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan (China) [Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan (China); Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan (China); Ho, Heng-Chien; Lee, Miau-Rong [Department of Biochemistry, China Medical University, Taichung 404, Taiwan (China)] [Department of Biochemistry, China Medical University, Taichung 404, Taiwan (China); Lai, Kuang-Chi [Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan (China) [Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan (China); School of Medicine, China Medical University, Taichung 404, Taiwan (China); Yeh, Chung-Min; Lin, Yueh-Min [Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan (China)] [Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan (China); Ho, Tin-Yun [School of Chinese Medicine, China Medical University, Taichung 404, Taiwan (China)] [School of Chinese Medicine, China Medical University, Taichung 404, Taiwan (China); Hsiang, Chien-Yun, E-mail: cyhsiang@mail.cmu.edu.tw [Department of Microbiology, China Medical University, Taichung 404, Taiwan (China)] [Department of Microbiology, China Medical University, Taichung 404, Taiwan (China); Chung, Jing-Gung, E-mail: jgchung@mail.cmu.edu.tw [Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan (China) [Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan (China); Department of Biotechnology, Asia University, Taichung 413, Taiwan (China)

2012-07-15T23:59:59.000Z

58

TGF-{beta}1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-{kappa}B/IL-6/MMP-2  

SciTech Connect (OSTI)

Research highlights: {yields} Rac1 mediates TGF-{beta}1-induced SW1990 invasion through MMP-2 secretion and activation. {yields} NADPH-generated ROS act downstream of Rac1 in TGF-{beta}1-challenged SW1990 cells. {yields} TGF-{beta}1-stimulated ROS activate NF-{kappa}B in SW1990 cells. {yields} NF{kappa}B-induced IL-6 release is required for secretion and activation of MMP-2 in SW1990 cells. -- Abstract: Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-{beta}1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic cancer cell types. In the present study, we investigated the signaling pathway involved in TGF-{beta}1-promoted MMP-2 secretion and invasion by human pancreatic cancer cells SW1990. Using specific inhibitors, we found that stimulation of these tumor cells with TGF-{beta}1 induced secretion and activation of the collagenase MMP-2, which was required for TGF-{beta}1-stimulated invasion. Our results also indicate that signaling events involved in TGF-{beta}1-enhanced SW1990 invasiveness comprehend activation of Rac1 followed by generation of reactive oxygen species through nicotinamide adenine dinucleotide phosphate-oxidase, activation of nuclear factor-kappa beta, release of interleukin-6, and secretion and activation of MMP-2.

Binker, Marcelo G. [Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 (Canada) [Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 (Canada); CBRHC Research Center, Buenos Aires (Argentina); Binker-Cosen, Andres A. [CBRHC Research Center, Buenos Aires (Argentina)] [CBRHC Research Center, Buenos Aires (Argentina); Gaisano, Herbert Y. [Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 (Canada)] [Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 (Canada); Cosen, Rodica H. de [CBRHC Research Center, Buenos Aires (Argentina)] [CBRHC Research Center, Buenos Aires (Argentina); Cosen-Binker, Laura I., E-mail: laura.cosen.binker@utoronto.ca [Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 (Canada); CBRHC Research Center, Buenos Aires (Argentina)

2011-02-04T23:59:59.000Z

59

High-loop perturbative renormalization constants for Lattice QCD (III): three-loop quark currents for Iwasaki gauge action and n_f=4 Wilson fermions  

E-Print Network [OSTI]

This is the third of a series of papers on three-loop computation of renormalization constants for Lattice QCD. Our main point of interest are results for the regularization defined by Iwasaki gauge action and n_f=4 Wilson fermions. Our results for quark bilinears renormalized according to the RI'-MOM scheme can be compared to non-perturbative results. The latter are available for Twisted Mass QCD: being defined in the chiral limit, renormalization constants must be the same. We also address more general problems. In particular, we discuss a few methodological issues connected to summing the perturbative series such as the effectiveness of Boosted Perturbation Theory and the disentanglement of irrelevant and finite volume contributions. Discussing these issues we consider ont only the new results of this paper, but also those for the regularization defined by tree-level Symanzik improved gauge action and n_f=2 Wilson fermions, which we presented in a recent paper of ours. We finally comment to which extent the techniques we put at work in the NSPT context can provide a fresher look into the lattice version of the RI'-MOM scheme.

M. Brambilla; F. Di Renzo; M. Hasegawa

2014-06-23T23:59:59.000Z

60

JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-{kappa}B activation and the JAK/STAT pathway  

SciTech Connect (OSTI)

JANEX-1/WHI-P131, a selective Janus kinase 3 (JAK3) inhibitor, has been shown to delay the onset of diabetes in the NOD mouse model. However, the molecular mechanism by which JANEX-1 protects pancreatic {beta}-cells is unknown. In the current study, we investigated the role of JANEX-1 on interleukin (IL)-1{beta} and interferon (IFN)-{gamma}-induced {beta}-cell damage using isolated islets. JANEX-1-pretreated islets showed resistance to cytokine toxicity, namely suppressed nitric oxide (NO) production, reduced inducible form of NO synthase (iNOS) expression, and decreased islet destruction. The molecular mechanism by which JANEX-1 inhibits iNOS expression was mediated through suppression of the nuclear factor {kappa}B (NF-{kappa}B) and JAK/signal transducer and activator of transcription (STAT) pathways. Islets treated with the cytokines downregulated the protein levels of suppressor of cytokine signaling (SOCS)-1 and SOCS-3, but pretreatment with JANEX-1 attenuated these decreases. Additionally, islets from JAK3{sup -/-} mice were more resistant to cytokine toxicity than islets from control mice. These results demonstrate that JANEX-1 protects {beta}-cells from cytokine toxicity through suppression of the NF-{kappa}B and JAK/STAT pathways and upregulation of SOCS proteins, suggesting that JANEX-1 may be used to preserve functional {beta}-cell mass.

Lv, Na; Kim, Eun-Kyung; Song, Mi-Young [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Choi, Ha-Na; Moon, Woo Sung [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Park, Sung-Joo [Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of)] [Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Kwon, Kang-Beom, E-mail: desson@wonkwang.ac.kr [Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of)] [Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Byung-Hyun, E-mail: bhpark@chonbuk.ac.kr [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)

2009-07-15T23:59:59.000Z

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61

Relation between two-point Green functions of ${\\cal N}=1$ SQED with $N_f$ flavors, regularized by higher derivatives, in the three-loop approximation  

E-Print Network [OSTI]

We verify the identity which relates the two-point Green functions of ${\\cal N}=1$ SQED with $N_f$ flavors, regularized by higher derivatives, by explicit calculations in the three-loop approximation. This identity explains why in the limit of the vanishing external momentum the two-point Green function of the gauge superfield is given by integrals of double total derivatives in the momentum space. It also allows to derive the NSVZ $\\beta$-function exactly in all loops if the renormalization group functions are defined in terms of the bare coupling constant. In order to verify the considered identity we use it for constructing integrals giving the three-loop $\\beta$-function starting from the two-point Green functions of the matter superfields in the two-loop approximation. Then we demonstrate that the results for these integrals coincide with the sums of the corresponding three-loop supergraphs.

A. E. Kazantsev; K. V. Stepanyantz

2014-10-05T23:59:59.000Z

62

Lattice NRQCD study of S- and P-wave bottomonium states in a thermal medium with $N_f=2+1$ light flavors  

E-Print Network [OSTI]

We investigate the properties of S-and P-wave bottomonium states in the vicinity of the deconfinement transition temperature. The light degrees of freedom are represented by dynamical lattice QCD configurations of the HotQCD collaboration with $N_f = 2 + 1$ flavors. Bottomonium correlators are obtained from bottom quark propagators, computed in Non-Relativistic QCD (NRQCD) under the background of these gauge field configurations. The spectral functions for the $^3S_1$ ($\\Upsilon$) and $^3P_1$ ($\\chi_{b1}$) channel are extracted from the Euclidean time correlators using a novel Bayesian approach in the temperature region $140 {\\rm MeV} \\le T \\le 249 {\\rm MeV}$ and the results are contrasted to those from the standard Maximum Entropy Method. We find that the new Bayesian approach is far superior to the Maximum Entropy Method and enables us to study reliably the first peak in the spectral functions even under the limitations present in the finite temperature setup. We find that $\\chi_{b1}$ survives up to $T=249 {\\rm MeV}$, the highest temperature considered in our study and put stringent constraints on the size of the medium modification of $\\Upsilon$ and $\\chi_{b1}$ states.

Seyong Kim; Peter Petreczky; Alexander Rothkopf

2014-09-12T23:59:59.000Z

63

Leptonic decay constants fK, fD and fDs with Nf = 2+1+1 twisted-mass lattice QCD  

E-Print Network [OSTI]

We present a lattice QCD calculation of the pseudoscalar decay constants fK, fD and fDs performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their values in the real world. The simulations are based on a unitary setup for the two light mass-degenerate quarks and on a mixed action approach for the strange and charm quarks. We use data simulated at three different values of the lattice spacing in the range 0.06 - 0.09 fm and at pion masses in the range 210 - 450 MeV. Our main results are: fK+ / fpi+ = 1.184 (16), fK+ = 154.4 (2.0) MeV, which incorporate the leading strong isospin breaking correction due to the up- and down-quark mass difference, and fK = 155.0 (1.9) MeV, fD = 207.4 (3.8) MeV, fDs = 247.2 (4.1) MeV, fDs / fD = 1.192 (22) and (fDs / fD) / (fK / fpi) = 1.003 (14) obtained in the isospin symmetric limit of QCD. Combined with the experimental measurements of the leptonic decay rates of kaon, pion, D- and Ds-mesons our results lead to the following determination of the CKM matrix elements: |Vus| = 0.2269 (29), |Vcd| = 0.2221 (67) and |Vcs| = 1.014 (24). Using the latest value of |Vud| from superallowed nuclear beta decays the unitarity of the first row of the CKM matrix is fulfilled at the permille level.

N. Carrasco; P. Dimopoulos; R. Frezzotti; P. Lami; V. Lubicz; F. Nazzaro; E. Picca; L. Riggio; G. C. Rossi; F. Sanfilippo; S. Simula; C. Tarantino

2015-02-25T23:59:59.000Z

64

Activation of ROS/NF-{kappa}B and Ca{sup 2+}/CaM kinase II are necessary for VCAM-1 induction in IL-1{beta}-treated human tracheal smooth muscle cells  

SciTech Connect (OSTI)

Histone acetylation regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) plays a critical role in the expression of inflammatory genes, such as vascular cell adhesion molecule-1 (VCAM-1). Oxidative processes have been shown to induce VCAM-1 expression. Here, we investigated the mechanisms underlying IL-1{beta}-induced VCAM-1 expression in human tracheal smooth muscle cells (HTSMCs). Our results showed that IL-1{beta} enhanced HTSMCs-monocyte adhesion through up-regulation of VCAM-1, which was inhibited by pretreatment with selective inhibitors of PKC{alpha} (Goe6976), c-Src (PP1), NADPH oxidase [diphenylene iodonium (DPI) and apocynin (APO)], intracellular calcium chelator (BAPTA/AM), PI-PLC (U73122), CaM (calmidazolium chloride), CaM kinase II (KN62), p300 (garcinol), NF-{kappa}B (Bay11-7082), HDAC (trichostatin A), and ROS scavenger [N-acetyl-L-cysteine (NAC)] or transfection with siRNAs of MyD88, PKC{alpha}, Src, p47{sup phox}, p300, and HDAC4. Moreover, IL-1{beta} stimulated NF-{kappa}B and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKC{alpha}/c-Src/ROS and PI-PLC/Ca{sup 2+}/CaM pathways, respectively. Activation of NF-{kappa}B and CaMKII may eventually lead to the acetylation of histone residues and phosphorylation of histone deacetylases. These findings suggested that IL-1{beta} induced VCAM-1 expression via these multiple signaling pathways in HTSMCs. Blockade of these pathways may reduce monocyte adhesion via VCAM-1 suppression and attenuation of the inflammatory responses in airway diseases.

Luo, S.-F. [Department of Internal Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Chang, C.-C.; Lee, I-T. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Lee, C.-W. [Department of Nursing, Division of Basic Medical Sciences, Chang Gung Institute of Technology, Chia-Yi, Taiwan (China); Lin, W.-N. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Lin, C.-C. [Department of Anesthetics, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Yang, C.-M. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China)], E-mail: chuenmao@mail.cgu.edu.tw

2009-05-15T23:59:59.000Z

65

The REMOTE SENSlNf  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou$0.C. 20545 OCTTO: FILE FROM:DEC. i_ Department1 / .'

66

Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-{kappa}B translocation  

SciTech Connect (OSTI)

Propofol (PPF), a widely used intravenous anesthetic for induction and maintenance of anesthesia during surgeries, was found to possess suppressive effect on host immunity. This study aimed at investigating whether PPF plays a modulatory role in the lipopolysaccharide (LPS)-induced inflammatory cytokine expression in a cell line of rat hepatocytes. Morphological observation and viability assay showed that PPF exhibits no cytotoxicity at concentrations up to 300 {mu}M after 48 h incubation. Pretreatment with 100 {mu}M PPF for 24 h prior to LPS stimulation was performed to investigate the modulatory effect on LPS-induced inflammatory gene production. The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-{alpha}, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression. Western blotting analysis showed that PPF pretreatment potentiated the LPS-induced TLR-4 downregulation. Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes. In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and I{kappa}B{alpha}, as well as the nuclear translocation of NF-{kappa}B primed by LPS. Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-{kappa}B nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. In conclusion, PPF as an anesthetic may clinically benefit those patients who are vulnerable to sepsis by alleviating sepsis-related inflammatory response in livers.

Jawan, Bruno [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Kao, Y.-H. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Goto, Shigeru [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Surgery, Iwao Hospital, 3059-1 Kawakami, Yufuin, Oita 879-5102 (Japan); Pan, M.-C. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Lin, Y.-C.; Hsu, L.-W.; Nakano, Toshiaki; Lai, C.-Y.; Sun, C.-K.; Cheng, Y.-F. [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Tai, M.-H. [Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Department of Medical Research and Education, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan (China)] (and others)

2008-06-15T23:59:59.000Z

67

D-Saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-?B and PKC signaling  

SciTech Connect (OSTI)

Increasing evidence suggests that oxidative stress is involved in the pathogenesis of diabetic nephropathy (DN) and this can be attenuated by antioxidants. D-Saccharic acid 1,4-lactone (DSL) is known for its detoxifying and antioxidant properties. Our early investigation showed that DSL can ameliorate alloxan (ALX) induced diabetes mellitus and oxidative stress in rats by inhibiting pancreatic ?-cell apoptosis. In the present study we, therefore, investigated the protective role of DSL against renal injury in ALX induced diabetic rats. ALX exposure (at a dose of 120 mg/kg body weight, i. p., once) elevated the blood glucose level, serum markers related to renal injury, the production of reactive oxygen species (ROS), and disturbed the intra-cellular antioxidant machineries. Oral administration of DSL (80 mg/kg body weight) restored all these alterations close to normal. In addition, DSL could also normalize the aldose reductase activity which was found to increase in the diabetic rats. Investigating the mechanism of its protective activity, we observed the activation of different isoforms of PKC along with the accumulation of matrix proteins like collagen and fibronectin. The diabetic rats also showed nuclear translocation of NF-?B and increase in the concentration of inflammatory cytokines in the renal tissue. The activation of mitochondria dependent apoptotic pathway was observed in the diabetic rat kidneys. However, treatment of diabetic rats with DSL counteracted all these changes. These findings, for the first time, demonstrated that DSL could ameliorate renal dysfunction in diabetic rats by suppressing the oxidative stress related signalling pathways. - Highlights: ? Sustained hyperglycemia and oxidative stress lead to diabetic renal injury. ? D-saccharic acid 1,4-lactone prevents renal damage in alloxan-induced diabetes. ? It restores intra-cellular antioxidant machineries and kidney apoptosis. ? DSL reduces hyperglycemia-mediated oxidative stress via NF-kB and PKC signaling. ? DSL may act as a beneficial agent in hyperglycemia induced renal disorder.

Bhattacharya, Semantee [Department of Life Sciences and Biotechnology, Jadavpur University, 188, Raja S C Mullick Road, Kolkata 700 032 (India); Manna, Prasenjit [Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054 (India); Gachhui, Ratan [Department of Life Sciences and Biotechnology, Jadavpur University, 188, Raja S C Mullick Road, Kolkata 700 032 (India); Sil, Parames C., E-mail: parames@bosemain.boseinst.ac.in [Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054 (India)

2013-02-15T23:59:59.000Z

68

Mercury Chamber NF-IDS Meeting  

E-Print Network [OSTI]

-Battelle for the U.S. Department of Energy Mercury Chamber Update Oct 2011 Starting Point: Coil and Shielding Concept IDS120H #12;3 Managed by UT-Battelle for the U.S. Department of Energy Mercury Chamber Update Oct 2011 · Penetrations (ports) into chamber ­ Nozzle ­ Hg drains (overflow and maintenance) ­ Vents (in and out) ­ Beam

McDonald, Kirk

69

Distinct functions of negative regulators of NF-kappaB  

E-Print Network [OSTI]

Kearns JD, Cheong R, Hoffmann A, Levchenko A. (2005) S, Werner SL, Huang CS, Hoffmann A. (2006) I?B? providesWare CF, Ghosh G, Verma IM, Hoffmann A. (2007) A fourth I?B

Kearns, Jeffrey D.

2009-01-01T23:59:59.000Z

70

Cloning and expression of equine NF-kB2  

E-Print Network [OSTI]

(transmembrane) gp 90 (surface) Matrix Membrane Nucleocapsid Viral RNA Integrase Reverse Transcriptase EIAV Virion LTR Tat Gag Pol Env Tat Rev Rev S2 LTR 6 Viral protease (p12) is needed for the processing of Pr55gag which accurse............................................................................................ 3 Pol Gene .......................................................................................... 4 Env Gene ......................................................................................... 6 Tat Gene...

Mirhosseini, Negin

2009-05-15T23:59:59.000Z

71

Distinct functions of negative regulators of NF-kappaB  

E-Print Network [OSTI]

J Immunol 174: 983-991. Emmerich F, Theurich S, Hummel M,specific (Doerre et al, 2005; Emmerich et al, 2003; Memet etDoerre et al, 2005; Emmerich et al, 2003; Memet et al, 1999;

Kearns, Jeffrey D.

2009-01-01T23:59:59.000Z

72

NF 3 , the greenhouse gas missing from Kyoto  

E-Print Network [OSTI]

Moreover, there is an economic incentive, a tradeoff betweenthere are economic as well as environmental incentives not

Prather, Michael J; Hsu, Juno

2008-01-01T23:59:59.000Z

73

NF kappa B expression and matrix metalloproteinase activity in hypertension  

E-Print Network [OSTI]

J. Silica attenuates hypertension in Lyon hypertensive rats.to experimental hypertension. J. Exp. Med. 115(6):1173-1190,Hypertensive Rat. Hypertension 52(2):415-423, 2008. Fabunmi

Wu, Kwan-I

2009-01-01T23:59:59.000Z

74

CMRR-NF Supplemental EIS Scoping Comments | National Nuclear Security  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New Substation Sites Proposed Route BTRIC CNMS CSMBLynda Nicely 800-248-1946,CMRR

75

ARM - VAP Product - aerich1nf1turn  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD) by MicrotopsProductsmwravg5mwravg Documentation Data Management Facility

76

Vol. 2003, Issue 36, pp. nf17, 10 September 2003 [DOI: 10.1126/sageke.2003.36.nf17  

E-Print Network [OSTI]

with memory disorders. (116K):View larger version [in this window] [in a new window] Adam Gazzaley is using and shadow, simplicity and complexity. Last month, he shot 32 rolls of film during a 2-week trip to Alaska

77

Insights into the regulation of NF-kappaB and mediation of the cellular stress response by NF-kappaB  

E-Print Network [OSTI]

Cancer Res 65, 4273-4281. Hoffmann, A. , Natoli, G. , andS.L. , Huang, C.S. , and Hoffmann, A. (2006). IkappaBepsilonK.I. , DiDonato, J.A. , Hoffmann, A. , Hardwick, J.M. , and

Ho, Jessica Q.

2010-01-01T23:59:59.000Z

78

Insights into the regulation of NF-kappaB and mediation of the cellular stress response by NF-kappaB  

E-Print Network [OSTI]

SDS sodium dodecyl sulfate TAD transcription activationtransactivating domains (TADs), which are thought to assistis because both p50 and p52 lack TAD domains, unlike p65, c-

Ho, Jessica Q.

2010-01-01T23:59:59.000Z

79

A NF-kappaB temporal code to ensure specificity in inflammatory signaling  

E-Print Network [OSTI]

Kearns, J. , Cheong, R. , Hoffmann, A. , and Levchenko, A.G. , Verma, I.M. , and Hoffmann, A. 2007. A fourth IkappaBWerner, S.L. , Regal, J. , Hoffmann, A. , and Levchenko, A.

Werner, Shannon L.

2009-01-01T23:59:59.000Z

80

Temporal encoding and homeostatic control in the IKK- kappaNF-kappaB signaling system  

E-Print Network [OSTI]

Nature 415(6868): 180-3. Hoffmann, A. and D. Baltimore (Immunol Rev 210: 171-86. Hoffmann, A. , A. Levchenko, etScience 298(5596): 1241-5. Hoffmann, A. , G. Natoli, et

Barken, Derren

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

akt-dependent nf-kappab activation: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

particles, which take energy from an internal replenishable energy depot or ambient medium and transduce it into useful work performed on the environment, in addition to...

82

Review of NF-IDS Targets Work Programme Status C. Densham, RAL, 17 November 2009  

E-Print Network [OSTI]

and services ? e) Cost of mercury system ? f) Cost of remote handling systems including shielding required ? g & containment TD Stalled c) Studies of irradiation, heat loads and cooling of decay solenoid JB, PL Underway d) Heat loads and cooling of shielding PL Stalled e) Solenoid system engineering, magnetic loads PL

McDonald, Kirk

83

attenuates nf-kappab-dependent icam-1: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and borehole acoustic models. The validity of the scheme is established using a 3D homogenous isotropic ... Krasovec, Mary L. 2003-01-01 29 THE ATTENUATED RAY TRANSFORM...

84

Estimation of (n,f) Cross-Sections by Measuring Reaction Probability Ratios  

SciTech Connect (OSTI)

Neutron-induced reaction cross-sections on unstable nuclei are inherently difficult to measure due to target activity and the low intensity of neutron beams. In an alternative approach, named the 'surrogate' technique, one measures the decay probability of the same compound nucleus produced using a stable beam on a stable target to estimate the neutron-induced reaction cross-section. As an extension of the surrogate method, in this paper they introduce a new technique of measuring the fission probabilities of two different compound nuclei as a ratio, which has the advantage of removing most of the systematic uncertainties. This method was benchmarked in this report by measuring the probability of deuteron-induced fission events in coincidence with protons, and forming the ratio P({sup 236}U(d,pf))/P({sup 238}U(d,pf)), which serves as a surrogate for the known cross-section ratio of {sup 236}U(n,f)/{sup 238}U(n,f). IN addition, the P({sup 238}U(d,d{prime}f))/P({sup 236}U(d,d{prime}f)) ratio as a surrogate for the {sup 237}U(n,f)/{sup 235}U(n,f) cross-section ratio was measured for the first time in an unprecedented range of excitation energies.

Plettner, C; Ai, H; Beausang, C W; Bernstein, L A; Ahle, L; Amro, H; Babilon, M; Burke, J T; Caggiano, J A; Casten, R F; Church, J A; Cooper, J R; Crider, B; Gurdal, G; Heinz, A; McCutchan, E A; Moody, K; Punyon, J A; Qian, J; Ressler, J J; Schiller, A; Williams, E; Younes, W

2005-04-21T23:59:59.000Z

85

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis  

E-Print Network [OSTI]

Intrinsic stress response pathways are frequently mobilized within tumor cells. The mediators of these adaptive mechanisms and how they contribute to carcinogenesis remain poorly understood. A striking example is heat shock ...

Dai, Chengkai

86

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network [OSTI]

organics in retentates from reverse osmosis wastewater reuseNDMA) removal by reverse osmosis and UV treatment andof N-nitrosamines by reverse osmosis membranes, Journal of

Mo, Yibing

2013-01-01T23:59:59.000Z

87

www.nasa.gov/aeronautics NF-2013-05-565-HQ  

E-Print Network [OSTI]

, emissions and fuel burn. A greener future for aviation holds the promise of new life for airports, because Headquarters 300 E. Street, SW Washington, DC 20546 NASA Facts Green Aviation: A Better Way to Treat the Planet engine emissions, unprecedented traffic jams in the sky, nonstop noise near airports, and more citizens

88

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network [OSTI]

methyl tert-butyl ether (MTBE), benzene, ethylbenzene,TCE** Industrial C 2 HCl 3 MTBE** [48] Industrial C 5 H 12 O

Mo, Yibing

2013-01-01T23:59:59.000Z

89

NF-[kappa]B RelB/p52 heterodimer : biogenesis and DNA recognition  

E-Print Network [OSTI]

derived factor-1 (SDF-1), B lymphocyte chemoattractant (BLC)Sequence Consensus ELC BLC SDF-1 New Consensus for RelB/p52from the CD39, BLC, ELC and SDF-1 promoters (Figure 3-21).

Fusco, Amanda J.

2007-01-01T23:59:59.000Z

90

Mechanism of gene regulation by the NF-kappaB p52 homodimer and Bcl3  

E-Print Network [OSTI]

of Bcl3.. 5. Generation of p50-RelA(TAD) andp52-RelA(TAD) Fusion Protein Constructs. 6.b) Expression of p50-RelA(TAD) and p52-RelA(TAD) fusion

Wang, Ya-Fan

2011-01-01T23:59:59.000Z

91

NF-[kappa]B RelB/p52 heterodimer : biogenesis and DNA recognition  

E-Print Network [OSTI]

5-10. Interactions of RelB TAD with p100 Figure 5-transactivation domain (TAD) at the N-terminus is shown inactivation domain (TAD). Homo- and heterodimers with at

Fusco, Amanda J.

2007-01-01T23:59:59.000Z

92

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network [OSTI]

1.1.1. Drinking water. . 1.1.2.concern (CECs) in drinking water 2.1.1. Classes ofOther Nitrosamines - Drinking Water Issues, in, 2011. [4

Mo, Yibing

2013-01-01T23:59:59.000Z

93

Results of radiological measurements taken in the Niagara Falls, New York, area (NF002)  

SciTech Connect (OSTI)

The results of a radiological survey of 100 elevated gamma radiation anomalies in the Niagara Falls, New York, area are presented. These radiation anomalies were identified by a mobile gamma scanning survey during the period October 3-16, 1984, and were recommended for an onsite survey to determine if the elevated levels of radiation may be related to the transportation of radioactive waste material to the Lake Ontario Ordnance Works for storage. In this survey, radiological measurements included outdoor gamma exposure rates at 1 m above the surface; outdoor gamma exposure rates at the surface, range of gamma exposure rates during scan; and uranium, radium, and thorium concentrations in biased surface soil samples. The results show 38 anomalies (35 located along Pletcher Road and 3 associated with other unreleated locations) were found to exceed Formerly Utilized Sites Remedial Action Program (FUSRAP) remedial action guidelines and were recommended for formal characterization surveys. (Since the time of this survey, remedial actions have been conducted on the 38 anomalies identified as exceeding FUSRAP guidelines, and the radioactive material above guidelines has been removed.) The remaining 62 anomalies are associated with asphalt driveways and parking lots, which used a phosphate slag material (previously identified as cyclowollastonite, synthetic CaSiO/sub 3/). This rocky-slag waste material was used for bedding under asphalt surfaces and in general gravel applications. Most of the contaminated soil and rock samples collected at the latter anomalies had approximately equal concentrations of /sup 226/Ra and /sup 238/U and, therefore, are not related to materials connected with the Niagara Falls Storage Site (NFSS), including material that was transported to the NFSS. 13 refs., 7 figs., 14 tabs.

Williams, J.K.; Berven, B.A.

1986-11-01T23:59:59.000Z

94

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network [OSTI]

oil that has been widely detected around petroleum and natural gas production sites, gas stations, and underground storage tanks.

Mo, Yibing

2013-01-01T23:59:59.000Z

95

Oil and Gas Wells: Regulatory Provisions (Kansas)  

Broader source: Energy.gov [DOE]

It shall be unlawful for any person, firm or corporation having possession or control of any natural gas well, oil well or coalbed natural gas well, whether as a contractor, owner, lessee, agent or...

96

Oil and Gas- Leases to remove or recover (Pennsylvania)  

Broader source: Energy.gov [DOE]

This act states that a lease or agreement conveying the right to remove or recover oil, natural gas or gas of any other designation from lessor to lessee shall not be valid if such lease does not...

97

Technical Support Document: Development of the Advanced Energy Design Guide for Grocery Stores--50% Energy Savings  

SciTech Connect (OSTI)

This report provides recommendations that architects, designers, contractors, developers, owners, and lessees of grocery store buildings can use to achieve whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004.

Hale, E. T.; Macumber, D. L.; Long, N. L.; Griffith, B. T.; Benne, K. S.; Pless, S. D.; Torcellini, P. A.

2008-09-01T23:59:59.000Z

98

Federal and Indian oil and gas royalty valuation and management  

SciTech Connect (OSTI)

This book covers: Royalty management-an M.M.S. overview; Payor/operator/lessee royalty liability; Royalty issues for OCS lessees; Royalty valuation procedures; Gas marketing royalty issues - industry perspective; Gas marketing royalty issues - M.M.S. perspective; Settlements of gas contract disputes Royalty reporting issues; Production reporting issues; Indian royalty issues; Litigation/regulatory updates; Over/under production on federal leases, units, and communitized areas; Audit program; and M.M.S. Reference Handbook.

Not Available

1992-01-01T23:59:59.000Z

99

A royalty pain in the gas: What costs may be properly deducted from a gas royalty interest?  

SciTech Connect (OSTI)

It is emphasized that parties contracting for oil and gas leases are always free to allocate the costs of compression, transportation and processing in their agreements, thereby avoiding many potential problems. However, it must be recognized that all too often lease agreements fail to apportion expenses that may be incurred after the discovery of oil or gas. In the likely event that the West Virginia courts are faced with this issue, they would be wise to adopt the implied duty to market theory, thereby, putting the onus on the lessee to either provide up front in the lease for the apportionment of costs after the discovery of the gas, or in those instances where the lease is silent as to who will incur the cost, to place the burden on the lessee to cover those costs. Regarding transportation costs, even in jurisdictions such as Oklahoma, where the lessee is obligated to develop the gas he has found so that it will bring the highest possible market value, the lessee is not required to provide for pipeline facilities beyond the lease premises. Kansas courts have also held that the lessee has a general duty to see that the gas is marketed, but that it is not required to pay the lessor`s share of transportation charges form the well to some distant place. Thus, in West Virginia when a gas lease is silent as what costs a lessee may properly deduct from a lessor`s royalty payment, the lessee should bear the costs under the implied duty to market theory if those costs do not involve enhancing the product or transporting it to some place of sale off the leased premises.

Raynes, R.S. Jr.

1996-10-01T23:59:59.000Z

100

MODULATION OF THE NF-KAPPA B SIGNALING PATHWAY BY THE BACTERIAL TYPE III SECRETION SYSTEM EFFECTORS  

E-Print Network [OSTI]

The type III secretion system (T3SS) is a bacterial injection system expressed by many Gram-negative bacteria. During the last two decades, the repertoire of T3SS effectors has been greatly explored, and several mechanisms ...

Gao, Xiaofei

2012-08-31T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

I kappa B epsilon provides negative feedback to control NF-kappa B oscillations, signaling dynamics, and inflammatory gene expression  

E-Print Network [OSTI]

Cancer Lett. 206: 193-199. Hoffmann, A. , and D. Baltimore.Immunol. Rev. 210:171-186. Hoffmann, A. , A. Levchenko, M.L.Science. 298:12411245. Hoffmann, A. , T.H. Leung, and D.

Kearns, Jeffrey D; Basak, Soumen; Werner, Shannon L; Huang, Christine S; Hoffmann, Alexander

2006-01-01T23:59:59.000Z

102

P105 and p100 proteins function as the core of heterogeneous NF-kappaB complexes  

E-Print Network [OSTI]

the p105 mutant protein that lacks a death domain, p105(1-and p105 mutant protein that lacks the C-terminal deaththat YFP-tagged p105 proteins that lack the ANK domain are

Savinova, Olga V.

2009-01-01T23:59:59.000Z

103

Modeling green fluorescent protein transcription, translation and modification as a method to obtain NF-kappaB activation profiles  

E-Print Network [OSTI]

Jayaraman Committee Members, Juergen Hahn Mike McShane Head of Department, N.K. Anand August 2007 Major Subject: Chemical Engineering iii ABSTRACT Modeling Green Fluorescent Protein Transcription, Translation and Modification as a Method... my profound thanks to my advisor, Dr. Arul Jayaraman, and my committee members, Dr. Juergen Hahn and Dr. Mike McShane, for their guidance and support throughout the course of this research. I would like to extend my gratitude to Jacky Huang who...

Laible, Allyson Marie

2009-05-15T23:59:59.000Z

104

I kappa B epsilon provides negative feedback to control NF-kappa B oscillations, signaling dynamics, and inflammatory gene expression  

E-Print Network [OSTI]

Immunol. 174:983991. Emmerich, F. , S. Theurich, M. Hummel,Spiecker et al. , 2000; Emmerich et al. , 2003; Doerre etSpiecker et al. , 2000; Emmerich et al. , 2003; Doerre et

Kearns, Jeffrey D; Basak, Soumen; Werner, Shannon L; Huang, Christine S; Hoffmann, Alexander

2006-01-01T23:59:59.000Z

105

ineralization of acid and sweet whey. There would be about 150 000200 000 m2 of NF  

E-Print Network [OSTI]

retention of monovalent ions and lower retention of lactose. Finally, optimal hydrodynamic conditions were defined in the range 3­6. Under these conditions, longer operating times, lower chemical oxygen demand processes are the most important parameters responsible for its ade- quate performance. In this way

Paris-Sud XI, Université de

106

QCD thermodynamics with $N_f=2+1$ near the continuum limit at realistic quark masses  

E-Print Network [OSTI]

We report on our study of QCD thermodynamics with 2+1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on $N_t=4$ and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of $m_q/m_s=0.05-0.4$. The lightest quark mass corresponds to a pion mass of about 150 MeV.

Takashi Umeda

2006-10-03T23:59:59.000Z

107

A R T I C L E p53 stabilization is decreased upon NF B activation: A role for  

E-Print Network [OSTI]

et al., 1995). Since transcrip-et al., 1996), and hypoxia (Graeber et al., 1994), lead to activation

Wahl, Geoffrey M.

108

Vector and scalar form factors for K- and D-meson semileptonic decays from twisted mass fermions with Nf = 2  

E-Print Network [OSTI]

We present lattice results for the form factors relevant in the K -> pion and D -> pion semileptonic decays, obtained from simulations with two flavors of dynamical twisted-mass fermions and pion masses as light as 260 MeV. For K -> pion decays we discuss the estimates of the main sources of systematic uncertainties, including the quenching of the strange quark, leading to our final result f+(0) = 0.9560 (57) (62). Combined with the latest experimental data, our value of f+(0) implies for the CKM matrix element |Vus| the value 0.2267 (5) (20) consistent with the first-row CKM unitarity. For D -> pion decays the application of Heavy Meson Chiral Perturbation Theory allows to extrapolate our results for both the scalar and the vector form factors at the physical point with quite good accuracy, obtaining a nice agreement with the experimental data. In particular at zero-momentum transfer we obtain f+(0) = 0.64 (5).

S. Di Vita; B. Haas; F. Mescia; V. Lubicz; S. Simula; C. Tarantino

2009-10-26T23:59:59.000Z

109

Nucleon form factors and structure functions with N_f=2+1 dynamical domain wall fermions  

E-Print Network [OSTI]

We report isovector form factors and low moments of structure functions of nucleon in numerical lattice quantum chromodynamics (QCD) from the on-going calculations by the RIKEN-BNL-Columbia (RBC) and UKQCD Collaborations with (2+1) dynamical flavors of domain-wall fermion (DWF) quarks. We calculate the matrix elements with four light quark masses, corresponding to pion mass values of m_\\pi = 330-670 MeV, while the dynamical strange mass is fixed at a value close to physical, on (2.7 fm)^3 spatial volume. We found that our axial charge, g_A, at the lightest mass exhibits a large deviation from the heavier mass results. This deviation seems to be a finite-size effect as the g_A value scales with a single parameter, m_\\pi L, the product of pion mass and linear spatial lattice size. The scaling is also seen in earlier 2-flavor dynamical DWF and Wilson quark calculations. Without this lightest point, the three heavier mass results show only very mild mass dependence and linearly extrapolate to g_A=1.16(6). We determined the four form factors, the vector (Dirac), induced tensor (Pauli), axial vector and induced pseudoscalar, at a few finite momentum transfer values as well. At the physical pion mass the form-factors root mean square radii determined from the momentum-transfer dependence %of the form factors are 20-30% smaller than the corresonding experiments. The ratio of the isovector quark momentum to helicity fractions, _{u-d}/_{\\Delta u - \\Delta d} is in agreement with experiment without much mass dependence including the lightest point. We obtain an estimate, 0.81(2), by a constant fit. Although the individual momentum and helicity fractions are yet to be renormalized, they show encouraging trend toward experiment.

RBC-UKQCD Collaborations; :; Takeshi Yamazaki; Shigemi Ohta

2007-10-02T23:59:59.000Z

110

Studies of resonantly produced plasmas in the H-1NF heliac using a far-infrared scanning interferometer  

E-Print Network [OSTI]

with an electric motor to provide a stable computer controlled rotational speed and to make the system acoustically and the other as a vibration monitor to compensate for wheel induced vibrations. With the grating wheel rotating and signal to noise ratio. We typically choose N 30. A Fourier shifting algorithm is used to correct

Howard, John

111

Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after  

E-Print Network [OSTI]

of the Negev, Beer-Sheva 84105, Israel b Department of Biotechnology and Environmental Engineering, Ben of the active layer gradually increases upon degradation, presumably due to disruption of the cross-links and/or generation of a larger number of hydrophilic groups. The change in swelling, which apparently proceeds

Freger, Viatcheslav "Slava"

112

Modulation of host NF-[k??a?p?p?a?]B pathway by the Toxoplasma gondii secreted factor, GRA15  

E-Print Network [OSTI]

The apicomplexan protozoan Toxoplasma gondii is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite ...

Lu, Diana, Ph. D. Massachusetts Institute of Technology

2013-01-01T23:59:59.000Z

113

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT G.L. Greene and N.F. Ramsey  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phases onOrganization FY Middle School ElectricDETEW!INATION OF THE

114

You've leased your land, but haven't been paid! Now what?  

E-Print Network [OSTI]

the lessee 60 to 90 days to pay. (This allows them time to complete a title search.) If you were working the most sense. You entered into a contact. They haven't fulfilled their obligations, so now is the time outlining the problem and state the terms of the lease: they have 30 or 60 (typically) days to make payment

Boyer, Elizabeth W.

115

Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics  

E-Print Network [OSTI]

), Uranium (U), Vanadium (V) Industrial chemicals include environmental pollutants and waste chemicals such as PBBs, PCBs, dioxins and furans, estrogens in the environment, pulp mill effluents, heavy metals, Radon and Radon decay products, Asbestos....6 Immunocytochemistry?????????.????????.??.... 66 2.7 Reporter gene assay???????????????????.??. 66 2.8 Western blot analysis???????????.???????.??.. 66 2.9 GST pull-down???????????????????????. 67 2.10 Co...

Gu, Xinsheng

2009-05-15T23:59:59.000Z

116

/7 soF'/t,,,,n,re D toPm NT". Using a Co nf=guration Management Tool to CoordInate  

E-Print Network [OSTI]

for coordination they provide, and their role in supporting a model of work. KEYWORDS: configuration management (CM of coordinating group work. This particular technology, a configuration management (CM) tool, incorporates begins with a description of configuration management, and how it involves coordinating the work

Grinter, Rebecca Elizabeth

117

Form factors of the $D \\to ?$ and $D \\to K$ semileptonic decays with $N_f = 2$ twisted mass lattice QCD  

E-Print Network [OSTI]

We present lattice results for the vector and scalar form factors of the semileptonic decays D -> \\pi \\ell \

S. Di Vita; B. Haas; V. Lubicz; F. Mescia; S. Simula; C. Tarantino; for the ETM Collaboration

2011-04-05T23:59:59.000Z

118

Leasing Texas Rangelands  

E-Print Network [OSTI]

, water, wildlife and game produc- tion, recreation, nature tourism, and aesthetic satisfaction. Based on the characteristics of their own range resources and the economic market, ranchers can profit from the consumer satisfaction their rangelands provide.... ? The expanding market for short-term consumer uses (hunting, nature tourism, recreation, etc.). The same basic requirements apply to all leases. In this publication, the grazing lease is used to illustrate important points for lessee and lessor to consider...

White, Larry D.; Whitson, Robert E.

1996-10-25T23:59:59.000Z

119

PENNSYLVANIA NATURAL GAS SUMMIT December 10, 2008  

E-Print Network [OSTI]

into the lease by stating that it would never pay more than $25 per acre. b) The royalty provision of the lease agreement violates Pennsylvania's Minimum Royalty Act, 58 P.S. § 33. 58 P.S. § 33 ­ "A lease or other to lessee shall not be valid if such lease does not guarantee the lessor at least one-eighth royalty of all

Boyer, Elizabeth W.

120

Interplay Between Liquid Crystalline And Isotropic Gels in Self-Assembled Neurofilament Networks  

SciTech Connect (OSTI)

Neurofilaments (NFs) are a major constituent of nerve cell axons that assemble from three subunit proteins of low (NF-L), medium (NF-M), and high (NF-H) molecular weight into a 10nm diameter rod with radiating sidearms to form a bottle-brush-like structure. Here, we reassemble NFs in vitro from varying weight ratios of the subunit proteins, purified from bovine spinal cord, to form homopolymers of NF-L or filaments composed of NF-L and NF-M (NF-LM), NF-L and NF-H (NF-LH), or all three subunits (NF-LMH). At high protein concentrations, NFs align to form a nematic liquid crystalline gel with a well-defined spacing determined with synchrotron small angle x-ray scattering. Near physiological conditions (86mM monovalent salt and pH 6.8), NF-LM networks with a high NF-M grafting density favor nematic ordering whereas filaments composed of NF-LH transition to an isotropic gel at low protein concentrations as a function of increasing mole fraction of NF-H subunits. The interfilament distance decreases with NF-M grafting density, opposite the trend seen with NF-LH networks. This suggests a competition between the more attractive NF-M sidearms, forming a compact aligned nematic gel, and the repulsive NF-H sidearms, favoring a more expansive isotropic gel, at 86mM monovalent salt. These interactions are highly salt dependent and the nematic gel phase is stabilized with increasing monovalent salt.

Jones, J.B.; Safinya, C.R.

2009-05-18T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


122

antibodies targeting cancer: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of an NF-B responsive element (pNF-B- Luc) encapsulated in a PRb peptide functionalized stealth targeted systems. In addition, we constructed a novel cancer therapeutic plasmid...

123

The effect of continuous, broad-band random noise, both alone and in combination with a food odor on the lemon shark, Negaprion brevirostris  

E-Print Network [OSTI]

parentheses) of that period in hours. 1878 (11) NFR FU SS8 (3) N NF FU 724 (12) NFs NF 490 (12) NF NF Fi C-1 FO C-2 RN8 FO 689 (30) NFg NF 2368 (28) NFq FU 2393 (12) N NF2 FU C-3 NF I RN NF, C-4 FIG. 6. Experiment ll2. Circular..." of the hourly response (see text). + = significance at n * = significance at o ; f = significance at a 400 1&IFOII CR QQN&FOHI ? C4~~RN ? I~C2? W 250 9 200 |50 Z 50 40 50 50 0 80 90 100 1 0 HOURS 37 exception (exp. 112, RN&FO). It should be noted...

Jones, Keith Anthony

2012-06-07T23:59:59.000Z

124

$ TfTiT7(TvJ/f^ Ris-M-2756 |g u w i i ^ i y / ntCtfCVW-D'""""  

E-Print Network [OSTI]

", G. Aeppli: "Muons, neutrons and superconductivity", N.F. Pedersen: "The Josephson junction", CVITY .... C. Aeppli THE JOSEPHSON JUNCTION N.F. Pedersen PHYSICOCHEMISTRY OF HIGH Tc SUPERCONDUCTORS C

125

Exercise training reverses age-induced inducible nitric oxide synthase upregulation  

E-Print Network [OSTI]

(SOL) ................................................................................37 5 iNOS activity in soleus (SOL) and white gastrocnemius (WG) .............................38 6 Total NOS activity in soleus (SOL) and white... gastrocnemius (WG).....................39 7 NF-? B DNA binding activity in white gastrocnemius (WG) .................................40 8 NF-? B DNA binding activity in soleus (SOL)........................................................41 9 NF...

Song, Wook

2005-02-17T23:59:59.000Z

126

Providing for adjustments of royalty payments under certain Federal onshore and Indian oil and gas leases, and for other purposes. House of Representatives, One Hundredth Congress, First Session, October 15, 1987  

SciTech Connect (OSTI)

The House report on H.R. 3479 adjusting royalty payments on oil and gas leases recommends passage with certain amendments. The recommended title for the Act is The Notice to Lessees No. 5 (NTL-5) Gas Royalty Act of 1987. The Act addresses problems involving some onshore and Indian leases, and redefines the procedures for determining the value of the lease. The report summarizes the purpose and need for the legislation, analyzes it by section, and concludes with communications between the committee and the Interior Department. A minority view argues in favor of placing the highest possible value on leases in order to be fair to taxpayers.

Not Available

1987-01-01T23:59:59.000Z

127

A game management plan for Rancho de los Jefes, Brooks County, Texas  

E-Print Network [OSTI]

; Dr. James G, Teer KAMEB Services, Inc. of Houston maintains a 4, 564, 9 hectare hunting lease in Brooks County, Texas for white-tailed deer (Ddocoileus vir inianus), wild turkeys )~Ml ~11 ' t d' ), j 1 )~P ~t (Zenaida macroura) . The objectives... of this study djere to evaluate present wildlife management practices employed on the lease and to develop a game management pl an whereby the wildlife resources on the lease will continue to provide benefits to the lessees. Initially, the major vegetative...

Frazier, Kenneth Durward

1976-01-01T23:59:59.000Z

128

Impact of geothermal development on stockraising homestead landowners  

SciTech Connect (OSTI)

Surface use and compensation conflicts have developed at the Geysers in California between owners of surface lands acquired under the Stockraising Homestead Act of 1916 and geothermal lessees with the right to develop the mineral interests reserved to the Federal Government. Several recommendations are made to the Secretary of the Interior concerning the problems identified. The following are discussed: conditions at the Geysers concerning geothermal development on stockraising lands that could be considered in regard to compensation, existence or potential for similar conflicts on this land outside the Geysers, protection and compensation provided surface owners in existence of legislation and the need for amendments, and alternative methods for paying compensation.

Not Available

1981-04-16T23:59:59.000Z

129

AZA-009176 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee 2 none

130

AZA-009177 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee 2 noneBLM

131

AZA-009178 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee 2

132

AZA-009179 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee 222

133

AZA-009180 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee

134

AZA-009181 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee8 Bid

135

AZA-009182 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee8

136

AZA-009183 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee82 Bid

137

AZA-009184 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee82 Bid24

138

AZA-009185 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee82

139

AZA-009186 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee821 Aliquot

140

AZA-009187 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee821

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

AZA-009188 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee821FOREST

142

AZA-009189 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON B Lessee821FOREST30

143

AZA-009191 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectric Coop,SaveWhiskey FlatshydroMultiple2 JumpHUNT NELSON BOIL USA INC Lessee

144

OROR-065720 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's HeatMexico:CommunityNorthwest Basin andNsbowde'sFracturesManualLLC Lessee

145

3D Model of the McGinness Hills Geothermal Area  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The McGinness Hills geothermal system lies in a ~8.5 km wide, north-northeast trending accommodation zone defined by east-dipping normal faults bounding the Toiyabe Range to the west and west-dipping normal faults bounding the Simpson Park Mountains to the east. Within this broad accommodation zone lies a fault step-over defined by north-northeast striking, west-dipping normal faults which step to the left at roughly the latitude of the McGinness Hills geothermal system. The McGinness Hills 3D model consists of 9 geologic units and 41 faults. The basal geologic units are metasediments of the Ordovician Valmy and Vininni Formations (undifferentiated in the model) which are intruded by Jurassic granitic rocks. Unconformably overlying is a ~100s m-thick section of Tertiary andesitic lava flows and four Oligocene-to-Miocene ash-flow tuffs: The Rattlesnake Canyon Tuff, tuff of Sutcliffe, the Cambell Creek Tuff and the Nine Hill tuff. Overlying are sequences of pre-to-syn-extensional Quaternary alluvium and post-extensional Quaternary alluvium. 10-15 eastward dip of the Tertiary stratigraphy is controlled by the predominant west-dipping fault set. Geothermal production comes from two west dipping normal faults in the northern limb of the step over. Injection is into west dipping faults in the southern limb of the step over. Production and injection sites are in hydrologic communication, but at a deep level, as the northwest striking fault that links the southern and northern limbs of the step-over has no permeability.

Faulds, James E.

146

3D Model of the McGinness Hills Geothermal Area  

SciTech Connect (OSTI)

The McGinness Hills geothermal system lies in a ~8.5 km wide, north-northeast trending accommodation zone defined by east-dipping normal faults bounding the Toiyabe Range to the west and west-dipping normal faults bounding the Simpson Park Mountains to the east. Within this broad accommodation zone lies a fault step-over defined by north-northeast striking, west-dipping normal faults which step to the left at roughly the latitude of the McGinness Hills geothermal system. The McGinness Hills 3D model consists of 9 geologic units and 41 faults. The basal geologic units are metasediments of the Ordovician Valmy and Vininni Formations (undifferentiated in the model) which are intruded by Jurassic granitic rocks. Unconformably overlying is a ~100s m-thick section of Tertiary andesitic lava flows and four Oligocene-to-Miocene ash-flow tuffs: The Rattlesnake Canyon Tuff, tuff of Sutcliffe, the Cambell Creek Tuff and the Nine Hill tuff. Overlying are sequences of pre-to-syn-extensional Quaternary alluvium and post-extensional Quaternary alluvium. 10-15 eastward dip of the Tertiary stratigraphy is controlled by the predominant west-dipping fault set. Geothermal production comes from two west dipping normal faults in the northern limb of the step over. Injection is into west dipping faults in the southern limb of the step over. Production and injection sites are in hydrologic communication, but at a deep level, as the northwest striking fault that links the southern and northern limbs of the step-over has no permeability.

Faulds, James E.

2013-12-31T23:59:59.000Z

147

A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer We validate the use of specific anti-Nf1 antibodies for immunofluorescence studies. Black-Right-Pointing-Pointer We detect Nf1 in the cytoplasm and nucleus of CCF cells. Black-Right-Pointing-Pointer We demonstrate that Nf1 partially colocalizes with PML nuclear bodies. Black-Right-Pointing-Pointer We demonstrate that there is a direct interaction between a fraction of Nf1 and the PML bodies. -- Abstract: Neurofibromatosis type 1 is a common genetic disease that causes nervous system tumors, and cognitive deficits. It is due to mutations within the NF1 gene, which encodes the Nf1 protein. Nf1 has been shown to be involved in the regulation of Ras, cAMP and actin cytoskeleton dynamics. In this study, using immunofluorescence experiments, we have shown a partial nuclear localization of Nf1 in the astrocytoma cell line: CCF and we have demonstrated that Nf1 partially colocalizes with PML (promyelocytic leukemia) nuclear bodies. A direct interaction between Nf1 and the multiprotein complex has further been demonstrated using 'in situ' proximity ligation assay (PLA).

Godin, Fabienne; Villette, Sandrine; Vallee, Beatrice; Doudeau, Michel; Morisset-Lopez, Severine [Centre de Biophysique Moleculaire, Centre National de la Recherche Scientifique (CNRS), UPR 4301, Universite d'Orleans et INSERM, rue Charles Sadron, 45071 Orleans Cedex 2 (France)] [Centre de Biophysique Moleculaire, Centre National de la Recherche Scientifique (CNRS), UPR 4301, Universite d'Orleans et INSERM, rue Charles Sadron, 45071 Orleans Cedex 2 (France); Ardourel, Maryvonne; Hevor, Tobias [Laboratoire de Neurobiologie, Universite d'Orleans, BP 6759, 45067 Orleans Cedex 2 (France)] [Laboratoire de Neurobiologie, Universite d'Orleans, BP 6759, 45067 Orleans Cedex 2 (France); Pichon, Chantal [Centre de Biophysique Moleculaire, Centre National de la Recherche Scientifique (CNRS), UPR 4301, Universite d'Orleans et INSERM, rue Charles Sadron, 45071 Orleans Cedex 2 (France)] [Centre de Biophysique Moleculaire, Centre National de la Recherche Scientifique (CNRS), UPR 4301, Universite d'Orleans et INSERM, rue Charles Sadron, 45071 Orleans Cedex 2 (France); Benedetti, Helene, E-mail: helene.benedetti@cnrs-orleans.fr [Centre de Biophysique Moleculaire, Centre National de la Recherche Scientifique (CNRS), UPR 4301, Universite d'Orleans et INSERM, rue Charles Sadron, 45071 Orleans Cedex 2 (France)] [Centre de Biophysique Moleculaire, Centre National de la Recherche Scientifique (CNRS), UPR 4301, Universite d'Orleans et INSERM, rue Charles Sadron, 45071 Orleans Cedex 2 (France)

2012-02-24T23:59:59.000Z

148

Broadband RF Front-End Design for Multi-Standard Receiver with High-Linearity and Low-Noise Techniques  

E-Print Network [OSTI]

. gm,CS and Vov,bias scaling at RCG = 200, RCS = 200/n, and ? = 43 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 35 NF vs. AV,CS at ? = 43 and Vov,bias Vov,CG = 1. . . . . . . . . . . . . . . . . . 59 36 Balun...-LNA. . . . . . . . . . . . . . . . . . . . 64 39 Simulated S11 and S21. . . . . . . . . . . . . . . . . . . . . . . . . . . 65 40 Simulated power gain (S21) and voltage gain (AV ) of Balun-LNA core. 65 41 Simulated NF and NF of balun-LNA core versus frequency. . . . . . 66 42 Simulated IIP...

Kim, Ju Sung

2012-02-14T23:59:59.000Z

149

E-Print Network 3.0 - anti-infective protective properties Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Immediate Past... petussis vaccine that is used to protect people from whooping cough. Ref: P Emsley, IG Charles , NF Source: Baird, Mark - Climate and Environmental...

150

E-Print Network 3.0 - anticarcinogenic enzyme inducers Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

upstream of NF-kB-inducing kinase (NIK), an enzyme which... , such as those present in green tea have been shown to exhibit cardioprotective and anticarcinogenic effects......

151

MINISTRIO DA EDUCAO UNIVERSIDADE FEDERAL DO PARAN  

E-Print Network [OSTI]

projetado para a medicao de indice de refracao (nD) e da dispersao optica media (NF-NC) da transparencia, ou

Paraná, Universidade Federal do

152

E-Print Network 3.0 - acute fetal hypoxia Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

70 mmHg) in developing larvae... investigated. The results revealed two distinct response patterns to acute hypoxia in "early" (NF stages 45... to acute hypoxia with a...

153

ITREOH building of regional capacity to monitor recreational water: Development of a non-commercial microcystin ELISA and its impact on public health policy  

E-Print Network [OSTI]

International Center; Uruguay, Rio de la Plata; waterRepublica, Montevideo, Uruguay (BMB, LD, NF); the Laboratoryof Montev- ideo, Uruguay (BMB, DS); the National Direction

2006-01-01T23:59:59.000Z

154

Insights into the homeostatic regulation of I kappa B alpha  

E-Print Network [OSTI]

Biol, 13, 1572-1582. Emmerich, F. , Meiser, M. , Hummel,fully inhibit NF-?B (Emmerich et al. , 1999; Jungnickel et

Lisabeth, Erika Mathes

2009-01-01T23:59:59.000Z

155

advanced membrane filtration: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

available reverse osmosis (RO) and nanofiltration (NF) membranes are based on the thin film composite (TFC) aromatic polyamide membranes. However, they have several disadvantages...

156

Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes  

E-Print Network [OSTI]

The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important ...

Lovell, Nathan Gary

2010-01-01T23:59:59.000Z

157

Dartmouth College HANOVER NEW HAMPSHIRE 03755-3586 Office of Pluralism and Leadership, Native American Program  

E-Print Network [OSTI]

_campaign=DartmouthNAP&utm_content=157886900294782 976&ref=nf Registrar's Office Link to the ORC http://dartmouth.smartcatalogiq.com/2012/orc

158

E-Print Network 3.0 - attenuates graft arteriosclerosis Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

polymer onto the membrane surface... . The structure of nanofiltration (NF) and reverse osmosis (RO) membranes modified using graft polymerization Source: Freger,...

159

Biologically Inspired Photocatalytically Active Membranes for Water Treatment  

E-Print Network [OSTI]

H. , Microbial fouling of reverse- osmosis membranes used inattention since reverse osmosis can be used to treatnanofiltration (NF), and reverse osmosis (RO) . Typically,

Kinsinger, Nichola

2013-01-01T23:59:59.000Z

160

E-Print Network 3.0 - ankyrin-repeat membrane protein Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

10 Stabilizing IB by "Consensus" Design Diego U. Ferreiro1,3 Summary: Keywords: protein folding; ankyrin repeat protein; NF-B; transcription factor; repeat protein...

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

E-Print Network 3.0 - ankyrin protein networks Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

>> 21 Stabilizing IB by "Consensus" Design Diego U. Ferreiro1,3 Summary: Keywords: protein folding; ankyrin repeat protein; NF-B; transcription factor; repeat protein...

162

,,"PARS II Interim Migration Template"  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

(HEPF)",,"04-D-103-02High Explosive Pressing Facility (HEPF)" ,,"June",,"04-D-125Chemistry & Metallurgy Research Facility Replacement -- NF (CMRR)",,,,,"04-D-125","Chemistry &...

163

TEA: Automatically proving termination of programs in a nonstrict higherorder functional  

E-Print Network [OSTI]

TEA: Automatically proving termination of programs in a non­strict higher­order functional language termination of functions written in a non­strict high­level functional programming language like Haskell kinds of termination: nf­termination and lazy termination. Intuitively, nf­termination of f means

Schmidt-Schauss, Manfred

164

Increasing Cancer-Specific Gene Expression by Targeting Overexpressed 51 Integrin and Upregulated Transcriptional  

E-Print Network [OSTI]

Engineering and Materials Science, University of Minnesota, 421 Washington Ave SE, Minneapolis, Minnesota the control of an NF-B responsive element (pNF-B- Luc) encapsulated in a PR_b peptide functionalized stealth was seen when transfected with PR_b functionalized stealth liposomes encapsulating the condensed p

Kokkoli, Efie

165

Nuclear Factor-KB Dimer Exchange Promotes a p21waf1/cip1 Superinduction Response in Human T Leukemic Cells  

E-Print Network [OSTI]

Nuclear Factor-KB Dimer Exchange Promotes a p21waf1/cip1 Superinduction Response in Human ability to induce p21waf1/cip1 . Here, we provide evidence that sequential NF-KB-activating signals induce heightened NF-KB DNA binding and p21waf1/cip1 induction in CEM and additional T leukemic cell lines

Miyamoto, Shigeki

166

Dr. Pete's useful stuff College Physics I*  

E-Print Network [OSTI]

/nelson Hooke's Law & SHM Friction NfNf kkss = kineticstatic Gravitation Quadratic functions ax2 + bx + c = 0 Momentum im= = p v P p rr rr Conservation laws for an isolated system i f i fE E P P= = simple pendulum k g

Nelson, Peter Hugo

167

The BMM Global-Local bijection for GL(n,q) fhm rinivsn  

E-Print Network [OSTI]

prtition of nF heorem @pongErinivsnA D re in the sme `Elok if nd only if D hve the sme eEoreF Bhama of nF heorem @pongErinivsnA D re in the sme `Elok if nd only if D hve the sme eEoreF Bhama Srinivasan

Srinivasan, Bhama

168

ENEA F. Zonca 1 Multiple space-time structure of low-frequency fluctuations in  

E-Print Network [OSTI]

techniques based on scale separation. 2 BF introduced by a number of authors in the late 70's (Coppi PRL77, Lee PFBW 77, Glasser PFBW 77, Pegoraro IAEA 78, Connor PRL 78, Dewar NF81) to conveniently treat (Coppi PRL77, Lee PFBW 77, Glasser PFBW 77, Pegoraro IAEA 78, Connor PRL 78, Dewar NF81) to conveniently

Zonca, Fulvio

169

Reason for Testing (Required-failure to include a diagnosis may delay testing. Include all pertinent diagnoses and ICD9 codes. Ie. Primary Lung Cancer 162.9 with metastasis to brain 198.3 and bone 198.5)  

E-Print Network [OSTI]

, NF1, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTCH1, PTEN, PTPN11, RB1, RET, RUNX1, SMO, STK11, TET2, TP53 MAP2K2 MET MPL MTOR MYC MYD88 NF1 NOTCH1 NPM1 NRAS PDGFRA PIK3CA PTCH1 PTEN PTPN11 RB1 RET RUNX1 SMO

Wang, David

170

Noise Suppression using a Perceptual Model for Wideband Speech Signals Joachim Thiemann  

E-Print Network [OSTI]

is derived from a method devel- oped by Soulodre [2] to remove camera noise from film soundtracks. Soulodre[n, p] (where p denotes the frame counter) is windowed by a window obtained from the square root of the Hann window, defined by h[n] = 1 2 1 - cos 2 n + 0.5 NF , (1) where n = 0, . . . , NF - 1. The f

Kabal, Peter

171

Quadratic and differential forms over function fields of Pfister quadrics in characteristic two*  

E-Print Network [OSTI]

@inst-mat.utalca.cl Abstract Let F be a field of characteristic 2. Let nFbe the F-space of differ- ential + nV a db, then let nF= 1Fand d : nF ! n+1Fbe the differential operato

172

ROCKY MOUNTAIN JOURNAL OF MATHEMATICS  

E-Print Network [OSTI]

factors of i = 1,...,t, j = 1,...,n-1, by n, we have nfAjm+i = (jmnf +nif -nf +n).-.(jmnf +nif) = (.(if - f +1) -j)...(nif - j) (modp), so that Multiplying both sides of this congruence by Bn = n(2n) .(tf n

Williams, Kenneth Stuart

173

Computing Needs Time Edward A. Lee  

E-Print Network [OSTI]

(CSR-CPS)), the U. S. Army Research Office (ARO #W911NF-07-2-0019), the U. S. Air Force Office essential prop- erties of the physical systems, most particularly the passage of time. It makes a case (CSR-CPS)), the U. S. Army Research Office (ARO #W911NF-07-2-0019), the U. S. Air Force Office

174

Mercury-Related Materials Studies  

E-Print Network [OSTI]

. Pawel, "Assessment of Cavitation-Erosion Resistance of Potential Pump Impeller Materials for Mercury of Cavitation Resistant Modifications to Type 316LN Stainless Steel in a Mercury Thermal Convection Loop," OakMercury-Related Materials Studies Van Graves IDS NF Ph M tiIDS-NF Phone Meeting Jan 26, 2010

McDonald, Kirk

175

Mercury-Related Materials Studies  

E-Print Network [OSTI]

Mercury-Related Materials Studies Van Graves IDS NF Ph M tiIDS-NF Phone Meeting Jan 26, 2010 #12 Evaluation of Cavitation Resistance of Type 316LN Stainless Steel in Mercury Using a Vibratory Horn," J. Nucl Pump Impeller Materials for Mercury Service at the Spallation Neutron Source," Oak Ridge National

McDonald, Kirk

176

Neurofilament Proteins in Avian Auditory Hair Cells  

E-Print Network [OSTI]

Neurofilament Proteins in Avian Auditory Hair Cells ELIZABETH C. OESTERLE,* DIANA I. LURIE avian inner ear by using immunocytochemical techniques. NF-M was detected in auditory hair cells and VIIIth cranial nerve neurons. NF-M-positive hair cells are first detected at embryonic day 11 (E11

Rubel, Edwin

177

Some results in the theory of genuine representations of the ...  

E-Print Network [OSTI]

of eigen functionals corresponding to ?. Theorem E. Let ? be smooth .... Sp2n(F) be the semi-direct product corresponding to this action. ..... enables the extension of c(,) to a 2-cocycle c(,) on GSp2n(F) which takes values in {1}: We define...

2013-04-21T23:59:59.000Z

178

Technical Support Document: Development of the Advanced Energy Design Guide for Medium Box Retail -- 50% Energy Savings  

SciTech Connect (OSTI)

This report provides recommendations that architects, designers, contractors, developers, owners, and lessees of medium box retail buildings can use to achieve whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004. The recommendations are given by climate zone and address building envelope, fenestration, lighting systems, HVAC systems, building automation and controls, outside air treatment, service water heating, plug loads, and photovoltaic systems. The report presents several paths to 50% savings, which correspond to different levels of integrated design. These are recommendations only, and are not part of a code or standard. The recommendations are not exhaustive, but we do try to emphasize the benefits of integrated building design, that is, a design approach that analyzes a building as a whole system, rather than as a disconnected collection of individually engineered subsystems.

Hale, E. T.; Macumber, D. L.; Long, N. L.; Griffith, B. T.; Benne, K. S.; Pless, S. D.; Torcellini, P. A.

2008-09-01T23:59:59.000Z

179

Influence of the Torsion Angle in 3,3'-Dimethyl-2,2'-bipyridine on the Intermediate Valence of Yb in (C5Me5)2 Yb(3,3'-Me2-bipy)  

SciTech Connect (OSTI)

The synthesis and X-ray crystal structures of Cp-2*Yb(3,3'-Me(2)bipy) and [Cp-2 Yb(3,3'-Me(2)bipy)][Cp-2 YbCl1.6I0.4]center dot CH2Cl2 are described. In both complexes, the NCCN torsion angles are approximately 40 degrees. The temperature-independent value of n(f) of 0.17 shows that the valence of ytterbium in the neutral adduct is multiconfigurational, in reasonable agreement with a CASSCF calculation that yields a n(f) value of 0.27; that is, the two configurations in the wave function are f(13)(pi(1))(1) and f(14)(pi(1))(0) in a ratio of 0.27:0.73, respectively, and the open-shell singlet lies 0.28 eV below the triplet state (n(f) accounts for f-hole occupancy; that is, n(f) = 1 when the configuration is f(13) and n(f) = 0 when the configuration is f(14)). A correlation is outlined between the value of nf and the individual ytterbocene and bipyridine fragments such that, as the reduction potentials of the ytterbocene cation and the free x,x'-R-2-bipy ligands approach each other, the value of nf and therefore the f(13):f(14) ratio reaches a maximum; conversely, the ratio is minimized as the disparity increases.

Nocton, Gr& #233; gory; Booth, Corwin H.; Maron, Laurent; Andersen, Richard A.

2014-06-26T23:59:59.000Z

180

Activation of the canonical nuclear factor-?B pathway is involved in isoflurane-induced hippocampal interleukin-1? elevation and the resultant cognitive deficits in aged rats  

SciTech Connect (OSTI)

Highlights: Isoflurane induces hippocampal IL-1? elevation and cognitive deficits in aged rats. Isoflurane transiently activates the canonical NF-?B pathway in aged rat hippocampus. NF-?B inhibitor mitigates isoflurane-induced IL-1? elevation and cognitive deficits. We report a linkage between NF-?B signaling, IL-1? expression, and cognitive changes. -- Abstract: Although much recent evidence has demonstrated that neuroinflammation contributes to volatile anesthetic-induced cognitive deficits, there are few existing mechanistic explanations for this inflammatory process. This study was conducted to investigate the effects of the volatile anesthetic isoflurane on canonical nuclear factor (NF)-?B signaling, and to explore its association with hippocampal interleukin (IL)-1? levels and anesthetic-related cognitive changes in aged rats. After a 4-h exposure to 1.5% isoflurane in 20-month-old rats, increases in I?B kinase and I?B phosphorylation, as well as a reduction in the NF-?B inhibitory protein (I?B?), were observed in the hippocampi of isoflurane-exposed rats compared with control rats. These events were accompanied by an increase in NF-?B p65 nuclear translocation at 6 h after isoflurane exposure and hippocampal IL-1? elevation from 1 to 6 h after isoflurane exposure. Nevertheless, no significant neuroglia activation was observed. Pharmacological inhibition of NF-?B activation by pyrrolidine dithiocarbamate markedly suppressed the IL-1? increase and NF-?B signaling, and also mitigated the severity of cognitive deficits in the Morris water maze task. Overall, our results demonstrate that isoflurane-induced cognitive deficits may stem from upregulation of hippocampal IL-1?, partially via activation of the canonical NF-?B pathway, in aged rats.

Li, Zheng-Qian; Rong, Xiao-Ying; Liu, Ya-Jie; Ni, Cheng [Department of Anesthesiology, Peking University Third Hospital, Beijing 100191 (China)] [Department of Anesthesiology, Peking University Third Hospital, Beijing 100191 (China); Tian, Xiao-Sheng [Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Ministry of Education and Ministry of Public Health, Peking University Health Science Center, Beijing 100191 (China)] [Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Ministry of Education and Ministry of Public Health, Peking University Health Science Center, Beijing 100191 (China); Mo, Na [Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021 (China)] [Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021 (China); Chui, De-Hua, E-mail: dchui@bjmu.edu.cn [Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Ministry of Education and Ministry of Public Health, Peking University Health Science Center, Beijing 100191 (China)] [Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Ministry of Education and Ministry of Public Health, Peking University Health Science Center, Beijing 100191 (China); Guo, Xiang-Yang, E-mail: puthmzk@163.com [Department of Anesthesiology, Peking University Third Hospital, Beijing 100191 (China)] [Department of Anesthesiology, Peking University Third Hospital, Beijing 100191 (China)

2013-09-06T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Renewable energy powered membrane technology. 2. The effect of energy fluctuations on performance of a photovoltaic hybrid membrane system  

E-Print Network [OSTI]

This paper reports on the performance fluctuations during the operation of a batteryless hybrid ultrafiltration nanofiltration / reverse osmosis (UF-NF/RO) membrane desalination system powered by photovoltaics treating ...

Richards, B.S.; Capo, D.P.S.; Schfer, Andrea

2008-01-01T23:59:59.000Z

182

Nitrogen trifluoride global emissions estimated from updated atmospheric measurements  

E-Print Network [OSTI]

Nitrogen trifluoride (NF[subscript 3]) has potential to make a growing contribution to the Earths radiative budget; however, our understanding of its atmospheric burden and emission rates has been limited. Based on a ...

Ivy, Diane J.

183

RIS-M-2408 Forsgsanlg RIS Juni 1984  

E-Print Network [OSTI]

BARSEBACKV?RKET MED ANDRF KERNFKRAFTWRKFR NfR STORRYFR OG LAMEfiRfNSER. ' INIS Descriptors BARSEBAECK-1 REACTOR 0418-6435 INIS Descriptors: BARSEBAECK-1 REACTOR, BAERSEBAECK2 REACTOR, BELGIUM, CANADA, COMPARATIVE

184

/NlT-2 : eAvsf's ;',,ett>v'soL .^^l ob  

E-Print Network [OSTI]

."\\;&- o J Z, \\ LL, J^n' 1 y \\ l', = \\/A' \\anrrt hho(lo( \\ y v o ) ,nf* it.uxlx : 27T[1('t-"is) o fr,--)n P

del Barco, Enrique

185

Bioremediation of contaminated groundwater  

DOE Patents [OSTI]

Disclosed is an apparatus and method for in situ remediation of contaminated subsurface soil or groundwater contaminated by chlorinated hydrocarbons. A nutrient fluid (NF) is selected to simulated the growth and reproduction of indigenous subsurface microorganisms capable of degrading the contaminants; an oxygenated fluid (OF) is selected to create an aerobic environment with anaerobic pockets. NF is injected periodically while OF is injected continuously and both are extracted so that both are drawn across the plume. NF stimulates microbial colony growth; withholding it periodically forces the larger, healthy colony of microbes to degrade the contaminants. Treatment is continued until the subsurface concentration of contaminants is acceptable. NF can be methane and OF be air, for stimulating production of methanotrophs to break down chlorohydrocarbons, especially TCE and tetrachloroethylene.

Hazen, T.C.; Fliermans, C.B.

1994-01-01T23:59:59.000Z

186

Dendritic Anion Hosts: Perchlorate Uptake by G5-NH2  

E-Print Network [OSTI]

may limit their utilization in drinking water treatment. Reverse osmosis (RO), nanofiltration (NF), and electrodialysis (ED) are also not cost-effective or efficient at recovering perchlorate from contaminated water

Goddard III, William A.

187

E-Print Network 3.0 - algorithms elucidate nrf2 Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Medicine 70 Kinetics and Mechanism of Protein Tyrosine Phosphatase 1B Inactivation by Acrolein Summary: channels (TRPA1) (17), and some transcription factors (NF-B, Keap1Nrf2)...

188

E-Print Network 3.0 - agent-sensor keap1 protein Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Medicine 48 Kinetics and Mechanism of Protein Tyrosine Phosphatase 1B Inactivation by Acrolein Summary: channels (TRPA1) (17), and some transcription factors (NF-B, Keap1Nrf2)...

189

Reciprocal Encoding of Signal Intensity and Duration  

E-Print Network [OSTI]

that an incoherent feedforward loop between three transcriptional regulators enhances the inflammatory response of intracellular calcium induces activation of the transcriptional activator NF-kB, whereas low sustained calcium

Jones, Alan M.

190

Synthesis and Characterization of Novel Fluorescent Injectable Micro-Carriers for Tissue Regeneration  

E-Print Network [OSTI]

Specific problem: Our previous study showed that the nanofibrous poly-l-lactic acid (NF-PLLA) microspheres are excellent cell carriers for tissue regeneration. However, these injectable microspheres are not fluorescent biomaterials. Incorporation...

Arora, Akshi

2014-04-28T23:59:59.000Z

191

Design and synthesis of probes for detection of protein-protein interaction and RNA localization  

E-Print Network [OSTI]

The use of the ketone biotin - benzophenone-biotin hydrazide system for detecting the formation of cyan fluorescent protein and NF-kappaB p50 dimers was assessed. A series of benzophenone-based probes were synthesized and ...

Ryan, Jeremy Adam

2005-01-01T23:59:59.000Z

192

The effects of community education on antisocial behavior occurring in public schools  

E-Print Network [OSTI]

. This basic premise has been elaborated upon by various theorists nf social disorgariza- tion in different ways. Contemporary use of the concept of soc. ial disorganization comes from W. !. ihomas and Florian Znaniecki (1927) who claim that social change...

Brown, Nan Ellyn

1977-01-01T23:59:59.000Z

193

Removal mechanisms of organic and inorganic solutes in raw, upland drinking water by nanofiltration: influence of solute-solute and solute-membrane interactions  

E-Print Network [OSTI]

Nanofiltration (NF) membranes have been applied successfully for the removal of inorganic and organic pollutants, including micropollutants, from drinking water for the past two decades. However, a complete and quantitative ...

De Munari, Annalisa; Munari, Annalisa de

2012-11-29T23:59:59.000Z

194

E-Print Network 3.0 - a431 cells identification Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 b-arrestin2 suppresses UV-induced NF... -arrestin-null MEFs and wild-type MEFs. (B) UV-induced degradation of IkBa was measured by immunoblot in A431 cells... by immunoblot...

195

Drawing Graphs in Euler Diagrams Paul Mutton1, Peter Rodgers1  

E-Print Network [OSTI]

Laboratory, University of Kent, Canterbury, Kent, CT2 7NF, UK {pjm2, P.J.Rodgers}@kent.ac.uk http://www.cs.kent.ac.uk/people/rpg/pjm

Kent, University of

196

CARIBBEA SEA MFR REPRINT 971  

E-Print Network [OSTI]

Cllasl nf nnrtheastern o uth GEORGE B. GROSS America. The present report describes the fisheri es, and the large shrimp are taken by trawl- ing in the adjacent open waters of the George B. Gross is Regional

197

E-Print Network 3.0 - active catheter navigation Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

nf@ffn f ff Jfn n f Summary: with a Haptic Catheter: Feeling the Inside of the Beating Heart Samuel B. Kesner 1 , Student Member, IEEE... -MIT Division of Health Sciences &...

198

Lattice QCD gauge ensemble: USQCD/MILC/asqtad/2064f21b678m010m050  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

MILC asqtad QCD SU(3) gauge ensemble; series=a; a=0.11fm minus 0.0022fm ; Ls=2.16fm; Nf=2+1; u0.m0=(0.010,0.050)

Aubin, Christopher Alan [Fordham U.; Bernard, Claude W. [Washington U. St. Louis; Burch, Tommy [U. Regensburg; Datta, Saumen [Tata Institute; DeGrand, Thomas Alan [Colorado U., Boulder; DeTar, Carleton E. [Utah U.; Gottlieb, Steven A. [Indiana U., Bloomington; Gregory, Eric Brittain [Wuppertal U.; Heller, Urs M. [American Physical Society; Hetrick, James Edward [U. Pacific, Stockton; Orginos, Kostas Nikolaou [William-Mary Coll.; Osborn, James C. [Argonne National Laboratory, ALCF; Toussaint, W. Doug [Arizona U.; Sugar, Robert L. [U. C., Santa Barbara

199

Lattice QCD gauge ensemble: USQCD/MILC/asqtad/2064f21b678m010m050b  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

MILC asqtad QCD SU(3) gauge ensemble; series=b; a=0.11fm minus 0.0022fm; Ls=2.16fm; Nf=2+1; u0.m0=(0.010,0.050)

Aubin, Christopher Alan [Fordham U.; Bernard, Claude W. [Washington U. St. Louis; Burch, Tommy [U. Regensburg; Datta, Saumen [Tata Institute; DeGrand, Thomas Alan [Colorado U., Boulder; DeTar, Carleton E. [Utah U.; Gottlieb, Steven A. [Indiana U., Bloomington; Gregory, Eric Brittain [Wuppertal U.; Heller, Urs M. [American Physical Society; Hetrick, James Edward [U. Pacific, Stockton; Orginos, Kostas Nikolaou [William-Mary Coll.; Osborn, James C. [Argonne National Laboratory, ALCF; Toussaint, W. Doug [Arizona U.; Sugar, Robert L. [U. C., Santa Barbara

200

SHUTTLE MENU STS-135 Stow By Day  

E-Print Network [OSTI]

*Day 1 consists of Meal C only **Day 13 consists of Meals A & B only (B) - Beverage, (FF)- Fresh Food, (I) - Irradiated, (IM) - Intermediate Moisture, (NF) - Natural Form, (R) - Rehydratable, (T

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Evaluation of Membrane Processes for Reducing Total Dissolved Solids Discharged to the Truckee River  

E-Print Network [OSTI]

for endangered species. Reverse osmosis RO and nanofiltration NF , in conjunction with ultrafiltration UF also have to be removed from the effluent in order to maintain their TMDLs. Reverse osmosis RO

202

Critical risk points of nanofiltration and reverse osmosis processes in water recycling applications  

E-Print Network [OSTI]

NF/RO membrane filtration processes have been recognized as an important technology to facilitate water recycling. Those processes are well-proven technologies, which can be used to remove a wide range of contaminants ...

Nghiem, Long D.; Schfer, Andrea

2006-01-01T23:59:59.000Z

203

Impact of pH on the removal of fluoride, nitrate and boron by nanofiltration/reverse osmosis  

E-Print Network [OSTI]

The objective of this study was to evaluate the impact of pH on boron, fluoride, and nitrate retention by comparing modelled speciation predictions with retention using six different nanofiltration (NF) and reverse osmosis ...

Richards, Laura A.; Vuachre, Marion; Schfer, Andrea

2010-01-01T23:59:59.000Z

204

Adsorption of Estrone on nanofiltration and reverse osmosis membranes in water and wastewater treatment  

E-Print Network [OSTI]

Adsorption of the trace contaminant estrone, a natural hormone and commonly abundant in surface waters and in treated as well as untreated wastewaters, to eight commercial nanofiltration (NF) and reverse osmosis (RO) ...

Nghiem, D.L.; Schfer, Andrea; Waite, T.D.

2002-01-01T23:59:59.000Z

205

Is Bloom's Taxonomy Appropriate for Computer Colin G. Johnson  

E-Print Network [OSTI]

Is Bloom's Taxonomy Appropriate for Computer Science? Colin G. Johnson Computing Laboratory University of Kent Canterbury, Kent, CT2 7NF England C.G.Johnson@kent.ac.uk Ursula Fuller Computing

Kent, University of

206

Search and notions of creativity Colin G. Johnson  

E-Print Network [OSTI]

Search and notions of creativity Colin G. Johnson Computing Laboratory University of Kent at Canterbury Canterbury, Kent, CT2 7NF, England C.G.Johnson@kent.ac.uk Abstract In this paper we consider

Kent, University of

207

Genetic Programming with Guaranteed Constraints Colin G. Johnson  

E-Print Network [OSTI]

Genetic Programming with Guaranteed Constraints Colin G. Johnson Computing Laboratory University of Kent at Canterbury Canterbury, Kent, CT2 7NF, England e-mail: C.G.Johnson@ukc.ac.uk Abstract: Genetic

Kent, University of

208

A Design Framework for Metaheuristics Colin G. Johnson  

E-Print Network [OSTI]

A Design Framework for Metaheuristics Colin G. Johnson School of Computing University of Kent Canterbury, Kent, CT2 7NF C.G.Johnson@kent.ac.uk Published in Artificial Intelligence Review, 29(2), April

Kent, University of

209

Using Tabu Search and Genetic Algorithms in Mathematics Colin G. Johnson  

E-Print Network [OSTI]

Using Tabu Search and Genetic Algorithms in Mathematics Research Colin G. Johnson Computing Laboratory University of Kent Canterbury, Kent, CT2 7NF, England e-mail: C.G.Johnson@kent.ac.uk Abstract

Kent, University of

210

Lattice QCD gauge ensemble: USQCD/MILC/asqtad/2064f21b678m010m050b  

SciTech Connect (OSTI)

MILC asqtad QCD SU(3) gauge ensemble; series=b; a=0.11fm minus 0.0022fm; Ls=2.16fm; Nf=2+1; u0.m0=(0.010,0.050)

Aubin, Christopher Alan [Fordham U.; Bernard, Claude W. [Washington U. St. Louis; Burch, Tommy [U. Regensburg; Datta, Saumen [Tata Institute; DeGrand, Thomas Alan [Colorado U., Boulder; DeTar, Carleton E. [Utah U.; Gottlieb, Steven A. [Indiana U., Bloomington; Gregory, Eric Brittain [Wuppertal U.; Heller, Urs M. [American Physical Society; Hetrick, James Edward [U. Pacific, Stockton; Orginos, Kostas Nikolaou [William-Mary Coll.; Osborn, James C. [Argonne National Laboratory, ALCF; Toussaint, W. Doug [Arizona U.; Sugar, Robert L. [U. C., Santa Barbara

2015-01-01T23:59:59.000Z

211

The Mobile Test and Demonstration Unit, A Cooperative Project Between EPRI, Utilities and Industry to Demonstrate New Water Treatment Technologies  

E-Print Network [OSTI]

and has demonstrated that membrane processes like MF, UF, NF and RO can successfully be applied to remove BOD and TSS from process streams, often recovering valuable solids, reducing sewer charges and meeting environmental regulations....

Strasser, J.; Mannapperuma, J.

212

RECIPIENT:Semprius  

Broader source: Energy.gov (indexed) [DOE]

concuning the proposed action, as Nf:PA Compliance Officer (authorized undcr DOE Order 45 I. IA), I have made the following determination: ex, EA, EIS APPENDIX ANI) NUMBER:...

213

Numerical Investigation of Interaction Between Hydraulic Fractures and Natural Fractures  

E-Print Network [OSTI]

Hydraulic fracturing of a naturally-fractured reservoir is a challenge for industry, as fractures can have complex growth patterns when propagating in systems of natural fractures in the reservoir. Fracture propagation near a natural fracture (NF...

Xue, Wenxu

2011-02-22T23:59:59.000Z

214

The ecology of coral-microbe interactions  

E-Print Network [OSTI]

algal symbioses. Molecular Ecology 18:1823-1833. Webster, N.F. Rohwer. 2008. Microbial ecology of four coral atolls inin Caribbean coral reefs. Ecology Letters 9:818-826. Porter,

Marhaver, Kristen Laura

2010-01-01T23:59:59.000Z

215

Biophysical Characterization of NEMO and IKK?  

E-Print Network [OSTI]

NF-?B IL-1? Signaling Overview Interstitial Fluid IL-1R TADNEMO TAD NPP IKK1 TAD N Cytosol IKK2 (Ub)n PP N TAD Nucleus TAD CBP et

Drew, Devin Lee

2006-01-01T23:59:59.000Z

216

Phase Resetting Reveals Network Dynamics Underlying a Bacterial Cell Cycle  

E-Print Network [OSTI]

promoter to express the essential transcriptional regulatory gene ctrA in a periodic, pulsed fashion perturbation spectroscopy (CPS). Citation: Lin Y, Li Y, Crosson S, Dinner AR, Scherer NF (2012) Phase Resetting

Scherer, Norbert F.

217

SIViP (2010) 4:319329 DOI 10.1007/s11760-009-0122-7  

E-Print Network [OSTI]

by the U.S. Army Research Office under Grant No. W911NF-07-1-0376, and by NASA under Cooperative Agreement in diverse applications (e.g., elect

Ray, Asok

218

A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE  

E-Print Network [OSTI]

was developed. HepG2 cells loaded with oleic acid surprisingly demonstrated lower cytotoxicity upon oxidative challenge (based on lactate dehydrogenase activity) and inflammation (based on TNF-? induced activation of the pro-inflammatory transcription factor NF...

Newton, Billy W.

2010-01-16T23:59:59.000Z

219

Systems and methods for treating material  

DOE Patents [OSTI]

Systems for treating material are provided that can include a vessel defining a volume, at least one conduit coupled to the vessel and in fluid communication with the vessel, material within the vessel, and NF.sub.3 material within the conduit. Methods for fluorinating material are provided that can include exposing the material to NF.sub.3 to fluorinate at least a portion of the material. Methods for separating components of material are also provided that can include exposing the material to NF.sub.3 to at least partially fluorinate a portion of the material, and separating at least one fluorinated component of the fluorinated portion from the material. The materials exposed to the NF.sub.3 material can include but are not limited to one or more of U, Ru, Rh, Mo, Tc, Np, Pu, Sb, Ag, Am, Sn, Zr, Cs, Th, and/or Rb.

Scheele, Randall D; McNamara, Bruce K

2014-10-21T23:59:59.000Z

220

Exploration of nucleon structure in lattice QCD with chiral quarks  

E-Print Network [OSTI]

In this work, we calculate various nucleon structure observables using the fundamental theory of quarks and gluons, QCD, simulated on a lattice. In our simulations, we use the full QCD action including Nf = 2+ 1 dynamical ...

Syritsyn, Sergey Nikolaevich

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Structural studies of magnesium nitride fluorides by powder neutron diffraction  

SciTech Connect (OSTI)

Samples of ternary nitride fluorides, Mg{sub 3}NF{sub 3} and Mg{sub 2}NF have been prepared by solid state reaction of Mg{sub 3}N{sub 2} and MgF{sub 2} at 1323-1423 K and investigated by powder X-ray and powder neutron diffraction techniques. Mg{sub 3}NF{sub 3} is cubic (space group: Pm3m) and has a structure related to rock-salt MgO, but with one cation site vacant. Mg{sub 2}NF is tetragonal (space group: I4{sub 1}/amd) and has an anti-LiFeO{sub 2} related structure. Both compounds are essentially ionic and form structures in which nitride and fluoride anions are crystallographically ordered. The nitride fluorides show temperature independent paramagnetic behaviour between 5 and 300 K. - Graphical abstract: Definitive structures of the ternary magnesium nitride fluorides Mg{sub 3}NF{sub 3} and the lower temperature polymorph of Mg{sub 2}NF have been determined from powder neutron diffraction data. The nitride halides are essentially ionic and exhibit weak temperature independent paramagnetic behaviour. Highlights: Black-Right-Pointing-Pointer Definitive structures of Mg{sub 3}NF{sub 3} and Mg{sub 2}NF were determined by neutron diffraction. Black-Right-Pointing-Pointer Nitride and fluoride anions are crystallographically ordered in both structures. Black-Right-Pointing-Pointer Both compounds exhibit weak, temperature independent paramagnetic behaviour. Black-Right-Pointing-Pointer The compounds are essentially ionic with ionicity increasing with F{sup -} content.

Brogan, Michael A. [School of Chemistry, University of Nottingham, Nottingham NG7 2RD (United Kingdom); Hughes, Robert W. [WestCHEM, School of Chemistry, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Smith, Ronald I. [ISIS Pulsed Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford, Didcot OX11 0QX (United Kingdom); Gregory, Duncan H., E-mail: Duncan.Gregory@glasgow.ac.uk [WestCHEM, School of Chemistry, University of Glasgow, Glasgow G12 8QQ (United Kingdom)

2012-01-15T23:59:59.000Z

222

Enhanced G2-M Arrest by Nuclear Factor-KB-Dependent p21waf1/cip1  

E-Print Network [OSTI]

Enhanced G2-M Arrest by Nuclear Factor-KB-Dependent p21waf1/cip1 Induction Shelly M. Wuerzberger cell death. Importantly, p21waf1/cip1 was induced in S-G2-M phases in a NF-KB-dependent manner, and RNA­coupled induction of p21waf1/cip1 by NF-KB represents a resistance mechanism in certain cancer cells. (Mol Cancer

Miyamoto, Shigeki

223

Dmarche qualit au sein d'un laboratoire de recherche du CNRS: FEMTO-ST  

E-Print Network [OSTI]

également lancés dans la mise en place de la norme NF EN ISO 9001 afin d'obtenir une certification : recherche, qualité, laboratoires, label Carnot, ISO 9001, ISO/CEI 17025, Université de Franche-Comté, FEMTO décennies des laboratoires accrédités par le COFRAC selon le référentiel NF EN ISO/CEI 17025. Ainsi, le

Paris-Sud XI, Université de

224

Memory Consolidation in Learning a Bimanual Coordination Skill  

E-Print Network [OSTI]

NOMENCLATURE IMM Immediate Group SLEEP Sleep Group LA Left Arm RA Right Arm AC Acquisition FB Feedback NF No-feedback RMSE Root Mean Square Error SD Standard Deviation MCD Mean Cycle Duration FR Frequency Ratio AMP Amplitude RMS Root Mean Square... xii LIST OF TABLES TABLE Page 1 Comparison of FR Distribution in NF Block (trials 14-16) between the Behind and Side Cursor Positions in the SLEEP Group. ................................. 33 1 CHAPTER I INTRODUCTION...

Wang, Chaoyi

2012-07-16T23:59:59.000Z

225

Donald Byrne (white) vs. Robert James "Bobby" Fischer (black) 1956 White Black  

E-Print Network [OSTI]

Donald Byrne (white) vs. Robert James "Bobby" Fischer (black) 1956 White Black 1. Nf3 Nf6 comments here are called "annotation" 2. c4 g6 3. Nc3 Bg7 black bishop sits on long diagonal 4. d4 0-0 white black threatens the queen 7. Qxc4 c6 8. e4 Nbd7 black's knight on b moves to d7 9. Rd1 Nb6 white's rook

Zirbel, Craig L.

226

Molecular pathogenesis of Salmonella enterica serotype Typhimurium-induced inflammatory responses  

E-Print Network [OSTI]

secretion of IL-8 (103) mediated by cytosolic calcium and NF?B translocation (53), and a NF?B-independent apical secretion of a pathogen- elicited epithelial chemoattractant (PEEC), identified as the eicosanoid hepoxilin A 3 , which directs PMNs through... intestinal epithelial cells (54, 106, 116). The polarized secretion of PEEC was induced by SipA through an Arf6-mediated lipid signaling 14 pathway and consequent redistribution and phosphorylation of protein kinase-C (PKC)? (27, 97, 152). The PMN...

Figueiredo, Josely Ferreira

2009-05-15T23:59:59.000Z

227

Inhibition of TNF-{alpha}-mediated inflammatory responses by a benzodioxolylacetylamino-linked benzothiazole analog in human fibroblast-like synoviocytes  

SciTech Connect (OSTI)

Highlights: {yields} We synthesized SPA0537, a benzothiazole analog. {yields} SPA0537 is a potent NF-{kappa}B inhibitor. {yields} SPA0537 suppresses the production of proinflammatory mediators in human rheumatoid fibroblast-like synoviocytes. {yields} SPA0537 is effective at suppressing osteoclast differentiation. -- Abstract: The pathologic processes of rheumatoid arthritis are mediated by a number of cytokines, chemokines, and matrix metalloproteinases, the expressions of which are controlled by NF-{kappa}B. This study was performed to explore the effects of a benzothiazole analog, SPA0537, on the control of the NF-{kappa}B activation pathway. We also investigated whether SPA0537 had any anti-inflammatory effects in human rheumatoid fibroblast-like synoviocytes (FLS). SPA0537 inhibited the nuclear translocation and the DNA binding of NF-{kappa}B subunits, which correlated with the inhibitory effects on IKK phosphorylation and I{kappa}B{alpha} degradation in TNF-{alpha}-stimulated rheumatoid FLS. These events further suppressed chemokine production, matrix metalloproteinase secretion, and TNF-{alpha}-induced cell proliferation. In addition, SPA0537 inhibited the osteoclast differentiation induced by macrophage colony-stimulating factor (MCSF) and receptor activator of the NF-{kappa}B ligand (RANKL) in bone marrow macrophages. These findings suggest that SPA0537 exerts anti-inflammatory effects in rheumatoid FLS through the inhibition of the NF-{kappa}B pathway. Therefore, it may have therapeutic value for the treatment of rheumatoid arthritis.

Lee, Young-Rae [Department of Biochemistry, Research Institute for Endocrine Sciences and Diabetes Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Research Institute for Endocrine Sciences and Diabetes Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Jin, Guo Hua [College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742 (Korea, Republic of)] [College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742 (Korea, Republic of); Lee, Sang-Myeong [Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan, Jeonbuk 570-752 (Korea, Republic of)] [Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan, Jeonbuk 570-752 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Research Institute for Endocrine Sciences and Diabetes Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Research Institute for Endocrine Sciences and Diabetes Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Ryu, Jae-Ha [College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742 (Korea, Republic of)] [College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742 (Korea, Republic of); Jeon, Raok, E-mail: rjeon@sm.ac.kr [College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742 (Korea, Republic of)] [College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742 (Korea, Republic of); Park, Byung-Hyun, E-mail: bhpark@jbnu.ac.kr [Department of Biochemistry, Research Institute for Endocrine Sciences and Diabetes Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Research Institute for Endocrine Sciences and Diabetes Research Center, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756 (Korea, Republic of)

2011-05-20T23:59:59.000Z

228

Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Ohio. Preliminary background report  

SciTech Connect (OSTI)

The Public Utilities Commission (PUCO) is a body created by the Ohio State legislature to administer the provisions of the Ohio Public Utilities Act. It is composed of three commissioners appointed by the governor with the advice and consent of the senate. Once appointed, a commissioner serves for a six-year period. The PUCO is vested with the power and jurisdiction to supervise and regulate public utilities and railroads... . The term public utility includes every corporation, company, co-partnership, person or association, their lessees, trustees, or receivers, as defined in the Ohio Code. Among the various services enumerated in the Code under the definition of public utility are an electric light company; a gas company; a pipeline company transporting gas, oil or coal; a waterworks company; a heating or cooling company. The power to regulate public utilities is shared by the PUCO and municipal governments. The municipal regulatory authority is derived from the Ohio Constitution, statutory provisions, and municipal franchising authority. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

1980-01-01T23:59:59.000Z

229

Naval Petroleum Reserves in California site environmental report for calendar year 1989  

SciTech Connect (OSTI)

This summary for Naval Petroleum Reserves in California (NPRC) is divided into NPR-1 and NPR-2. Monitoring efforts at NPR-1 include handling and disposal of oilfield wastes; environmental preactivity surveys for the protection of endangered species and archaeological resources; inspections of topsoil stockpiling; monitoring of revegetated sites; surveillance of production facilities for hydrocarbons and oxides of nitrogen (NO{sub x}) emissions; monitoring of oil spill prevention and cleanup; and monitoring of wastewater injection. No major compliance issues existed for NPR-1 during 1989. Oil spills are recorded, reviewed for corrective action, and reported. Environmental preactivity surveys for proposed projects which may disturb or contaminate the land are conducted to prevent damage to the federally protected San Joaquin kit fox, blunt-nosed leopard lizard, Tipton kangaroo rat and the giant kangaroo rat. Projects are adjusted or relocated as necessary to avoid impact to dens, burrows, or flat-bottomed drainages. A major revegetation program was accomplished in 1989 for erosion control enhancement of endangered species habitat. The main compliance issue on NPR-2 was oil and produced water discharges into drainages by lessees. An additional compliance issue on NPR-2 is surface refuse from past oilfield operations. 17 refs.

Not Available

1989-01-01T23:59:59.000Z

230

Proposed natural gas protection program for Naval Oil Shale Reserves Nos. 1 and 3, Garfield County, Colorado  

SciTech Connect (OSTI)

As a result of US Department of Energy (DOE) monitoring activities, it was determined in 1983 that the potential existed for natural gas resources underlying the Naval Oil Shales Reserves Nos. 1 and 3 (NOSrs-1 3) to be drained by privately-owned gas wells that were being drilled along the Reserves borders. In 1985, DOE initiated a limited number of projects to protect the Government's interest in the gas resources by drilling its own offset production'' wells just inside the boundaries, and by formally sharing in the production, revenues and costs of private wells that are drilled near the boundaries ( communitize'' the privately-drilled wells). The scope of these protection efforts must be expanded. DOE is therefore proposing a Natural Gas Protection Program for NOSRs-1 3 which would be implemented over a five-year period that would encompass a total of 200 wells (including the wells drilled and/or communitized since 1985). Of these, 111 would be offset wells drilled by DOE on Government land inside the NOSRs' boundaries and would be owned either entirely by the Government or communitized with adjacent private land owners or lessees. The remainder would be wells drilled by private operators in an area one half-mile wide extending around the NOSRs boundaries and communitized with the Government. 23 refs., 2 figs., 6 tabs.

Not Available

1991-08-01T23:59:59.000Z

231

Basic data report for drillhole WIPP 15 (Waste Isolation Pilot Plant-WIPP)  

SciTech Connect (OSTI)

WIPP 15 is a borehole drilled in Marformation.h, 1978, in section 18, T.23S., R. 35E. of south-central Lea County. The purpose of WIPP 15 was to examine fill in San Simon Sink in order to extract climatic information and to attempt to date the collapse of the sink. The borehole was cored to total depth (810.5 feet) and encountered, from top to bottom, Quaternary calcareous clay, marl and sand, the claystones and siltstones of the Triassic Santa Rosa Formation. Neutron and gamma ray geophysical logs were run to measure density and radioactivity. The sink was about 547 feet of Quaternary fill indicating subsidence and deposition. Diatomaceous beds exposed on the sink margin yielded samples dated by /sup 14/C at 20,570 +- 540 years BP and greater than 32,000 years BP; these beds are believed stratigraphically equivalent to ditomaceous beds at 153 to 266 feet depth in the core. Aquatic fauna and flora from the upper 98 feet of core indicate a pluvial period (probably Tohokan) followed by an arid or very arid time before the present climate was established. Aquifer pump tests performed in the Quaternary sands and clays show transmissivities to be as high as 600 feet squared per day. As the water quality was good, the borehole was released to the lessee as a potential water well.

Not Available

1981-11-01T23:59:59.000Z

232

Calculating the chiral condensate diagrammatically at strong coupling  

E-Print Network [OSTI]

We calculate the chiral condensate of QCD at infinite coupling as a function of the number of fundamental fermion flavours using a lattice diagrammatic approach inspired by recent work of Tomboulis, and other work from the 80's. We outline the approach where the diagrams are formed by combining a truncated number of sub-diagram types in all possible ways. Our results show evidence of convergence and agreement with simulation results at small Nf. However, contrary to recent simulation results, we do not observe a transition at a critical value of Nf. We further present preliminary results for the chiral condensate of QCD with symmetric or adjoint representation fermions at infinite coupling as a function of Nf for Nc = 3. In general, there are sources of error in this approach associated with miscounting of overlapping diagrams, and over-counting of diagrams due to symmetries. These are further elaborated upon in a longer paper.

Christensen, Alexander S; Pedersen, Peter D; Rosseel, Jan

2015-01-01T23:59:59.000Z

233

Quantum and stringy corrections to the equation of state of holographic QCD matter and the nature of the chiral transition  

E-Print Network [OSTI]

We consider the finite temperature phase diagram of holographic QCD in the Veneziano limit (Nc large, Nf large with xf=Nf/Nc fixed) and calculate one string-loop corrections to the free energy in certain approximations. Such corrections, especially due to the pion modes are unsuppressed in the Veneziano limit. We find that under some extra assumptions the first order transition following from classical gravity solutions can become second order. If stringy asymptotics are of a special form and there are residual interactions it may even become of third order. Operationally these computations imply modelling the low temperature chiral symmetry breaking phase with a hadron gas containing Nf^2 massless Goldstone bosons and an exponential spectrum of massive hadrons. A third order transition is possible only if repulsive hadron interactions via the excluded volume effect are included.

T. Alho; M. Jarvinen; K. Kajantie; E. Kiritsis; K. Tuominen

2015-03-26T23:59:59.000Z

234

First order switched-capacitor building blocks for analog circuits  

E-Print Network [OSTI]

of the stray sensitive configuration with V3 connected to V and V2 grounded . C 1 =4 . 5 91 nF 0 C3=255. 4pP, and C4=14. 7nF. 32 15 Magnitude response of the stray sensitive configuration with V3 connected to VO and Vl grounded. Cp4. 591nF, C3=255. 4p... capacitor, stray sensitive configuration with Vl connected to V , V2 grounded and C4 in parallel with C5. . . . . . 56 0 30 Phase response of the integrated version of the common capacitor, stray sensitive configuration with V connected to V, V grounded...

Nguyen, Liem Thanh

2012-06-07T23:59:59.000Z

235

Quantum and stringy corrections to the equation of state of holographic QCD matter and the nature of the chiral transition  

E-Print Network [OSTI]

We consider the finite temperature phase diagram of holographic QCD in the Veneziano limit (Nc large, Nf large with xf=Nf/Nc fixed) and calculate one string-loop corrections to the free energy in certain approximations. Such corrections, especially due to the pion modes are unsuppressed in the Veneziano limit. We find that under some extra assumptions the first order transition following from classical gravity solutions can become second order. If stringy asymptotics are of a special form and there are residual interactions it may even become of third order. Operationally these computations imply modelling the low temperature chiral symmetry breaking phase with a hadron gas containing Nf^2 massless Goldstone bosons and an exponential spectrum of massive hadrons. A third order transition is possible only if repulsive hadron interactions via the excluded volume effect are included.

Alho, T; Kajantie, K; Kiritsis, E; Tuominen, K

2015-01-01T23:59:59.000Z

236

The design of efficient input circuits for class C amplifiers  

E-Print Network [OSTI]

?XXXXXXXXXXXXXXXXXXXXXXXXXXX?? ??X ??o?? hen?in? c?o?ef? tiinf?s?sfg o? g?s rn?eo jis??sf?? linfd?eggsi X ? ? ? ? ? ? ? ? X X X X X X X ?? m?cl aj lt?m?c lt?m? ?n?s ?? uni?ofe? tfn??ded o? ?nien? linfd?oi?si XXXXXXXXXXXXXXXXXXXXXXXX ?? ??X ?snd?is? nf? ?n????ngs? a...?geof ???? ??????? l?s ?fdgeg?gs o? rn?eo ?f?efssidX jX ?X lsi?nf? ?rn?eo sf?efssief????? ???in? ue?? ?oo? ?o??nf?? ????X ??X mX ??siegg? ??a?ge??? o?singef? ?of?egeofd ?oi ??ndd ? n???e?esid?? ?io?ss?ef?d o? ?fdgeg?gs o? rn?eo ?f?efssid ??? ??? ??????X ??jX ?X...

Fristoe, Harold T.

2013-10-04T23:59:59.000Z

237

Delineating role of ubiquitination on nuclear factor-kappa B pathway by a computational modeling approach  

SciTech Connect (OSTI)

Mutant ubiquitin found in neurodegenerative diseases has been thought to hamper activation of transcription factor nuclear factor-kappa B (NF-{kappa}B) by inhibiting ubiquitin-proteasome system (UPS). It has been reported that ubiquitin also is involved in signal transduction in an UPS-independent manner. We used a modeling and simulation approach to delineate the roles of ubiquitin on NF-{kappa}B activation. Inhibition of proteasome complex increased maximal activation of IKK mainly by decreasing the UPS efficiency. On the contrary, mutant ubiquitin decreased maximal activity of IKK. Computational modeling showed that the inhibition effect of mutant ubiquitin is mainly attributed to decreased activity of UPS-independent function of ubiquitin. Collectively, our results suggest that mutant ubiquitin affects NF-{kappa}B activation in an UPS-independent manner.

Lee, Jungsul; Choi, Kyungsun [Cell Signaling and BioImaging Laboratory, Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea, Republic of)] [Cell Signaling and BioImaging Laboratory, Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea, Republic of); Choi, Chulhee, E-mail: cchoi@kaist.ac.kr [Cell Signaling and BioImaging Laboratory, Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea, Republic of) [Cell Signaling and BioImaging Laboratory, Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea, Republic of); Graduate School of Medical Science and Engineering, KAIST, Daejeon 305-701 (Korea, Republic of); KI for Bio Century, KAIST, Daejeon 305-701 (Korea, Republic of)

2010-01-01T23:59:59.000Z

238

Chemopreventive Potential of Sorghum with Different Phenolic Profiles  

E-Print Network [OSTI]

potential damage from free radicals to cells (45). The cancer initiation blockers can also stimulate molecular pathways, such as Nrf2 (nuclear factor-erythroid 2p45 (NF- E2)-related factor 2) to activate the production of protective phase II enzymes... elements (AREs). Basic leucine zipper (bZIP) transcription factors ? including NRF (NF-E2 related factor)? bind to these ARE sequences and modulate expression of stress-response genes. NRF2-KEAP1 (Kelch-like ECH-associated protein 1, a negative regulator...

Yang, Liyi

2010-07-14T23:59:59.000Z

239

Toward a Unified Treatment of Electronic Processes in Organic Semiconductors  

SciTech Connect (OSTI)

A quantitative study of n-type doping in highly crystalline organic semiconductor films establishes the predominant influence of electrostatic forces in these low-dielectric materials. Based on these findings, a self-consistent model of doped (purposely or not) organic semiconductors is proposed in which: (1) the equilibrium free carrier density, nf, is a small fraction of the total charge density; (2) a superlinear increase in conductivity with doping density is universal; (3) nf increases with applied electric field; and (4) the carrier mobility is field-dependent regardless of crystallinity.

Gregg. B.A.

2005-01-01T23:59:59.000Z

240

Report on thermal aging effects on tensile properties of ferritic-martensitic steels.  

SciTech Connect (OSTI)

This report provides an update on the evaluation of thermal-aging induced degradation of tensile properties of advanced ferritic-martensitic steels. The report is the first deliverable (level 3) in FY11 (M3A11AN04030103), under the Work Package A-11AN040301, 'Advanced Alloy Testing' performed by Argonne National Laboratory, as part of Advanced Structural Materials Program for the Advanced Reactor Concepts. This work package supports the advanced structural materials development by providing tensile data on aged alloys and a mechanistic model, validated by experiments, with a predictive capability on long-term performance. The scope of work is to evaluate the effect of thermal aging on the tensile properties of advanced alloys such as ferritic-martensitic steels, mod.9Cr-1Mo, NF616, and advanced austenitic stainless steel, HT-UPS. The aging experiments have been conducted over a temperature of 550-750 C for various time periods to simulate the microstructural changes in the alloys as a function of time at temperature. In addition, a mechanistic model based on thermodynamics and kinetics has been used to address the changes in microstructure of the alloys as a function of time and temperature, which is developed in the companion work package at ANL. The focus of this project is advanced alloy testing and understanding the effects of long-term thermal aging on the tensile properties. Advanced materials examined in this project include ferritic-martensitic steels mod.9Cr-1Mo and NF616, and austenitic steel, HT-UPS. The report summarizes the tensile testing results of thermally-aged mod.9Cr-1Mo, NF616 H1 and NF616 H2 ferritic-martensitic steels. NF616 H1 and NF616 H2 experienced different thermal-mechanical treatments before thermal aging experiments. NF616 H1 was normalized and tempered, and NF616 H2 was normalized and tempered and cold-rolled. By examining these two heats, we evaluated the effects of thermal-mechanical treatments on material microstructures and associated mechanical properties during long-term aging at elevated temperatures. Thermal aging experiments at different temperatures and periods of time have been completed: 550 C for up to 5000 h, 600 C for up to 7500 h, and 650 C for more than 10,000 h. Tensile properties were measured on thermally aged specimens and aging effect on tensile behavior was assessed. Effects of thermal aging on deformation and failure mechanisms were investigated by using in-situ straining technique with simultaneous synchrotron XRD measurements.

Li, M.; Soppet, W.K.; Rink, D.L.; Listwan, J.T.; Natesan, K. (Nuclear Engineering Division)

2012-05-10T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

The determination of the moisture absorption characteristics of lightweight concrete aggregates  

E-Print Network [OSTI]

'. ! on A & p&. d Me I I l. A New Me&h'd nf les& Kesul ts nf Test s &v the New Method t ''n&. !us& Appendix A Exp. ::m n? ! Data . u ne &di x, t&. Standard Me&bud of Test for Specific. Grav& tv and Absorption of Coarse Aggregate Appendix ( S...&sndsrd Method of Test for Specific Grsvitv nd Abso& pt &un of Fine Aggregate Appe &dix D Standard Definitions of Terms Relating tn Specific Gravity Appendi x E A D! rec t Method of Determining Absorption and Specific Gravitv of Aggregates hy Edwi~ L. Saxer...

Bryant, Julian Stephen

1959-01-01T23:59:59.000Z

242

Genetic analyses of bovine CARD15, a putative disease resistance gene  

E-Print Network [OSTI]

Through a binding partner the CARD15 gene activates NF-kB, a molecule with a role in the initiation of the inflammatory immune response. The gene is highly conserved in both structure and function in human and mouse and has recently been implicated...

Taylor, Kristen Hawkins

2004-09-30T23:59:59.000Z

243

Nitrogen trifluoride global emissions estimated from updated atmospheric measurements  

E-Print Network [OSTI]

Nitrogen trifluoride global emissions estimated from updated atmospheric measurements Tim Arnolda,1's radiative budget; however, our understand- ing of its atmospheric burden and emission rates has been limited together with an atmo- spheric model and inverse method, we estimate that the global emissions of NF3

Severinghaus, Jeffrey P.

244

J. Phys. II France 2 (1992) 715-725 APRIL1992, PAGE 715 Classification  

E-Print Network [OSTI]

.80D High f double-Rydberg states 7d5/2nf of barium P. Camus, 3.-M. Lecomte, C-R- Mahon, P. Pilfer presents the onset of correlation and the breakdown of the independent particle model. Camus et al. [15

Paris-Sud XI, Université de

245

Quark-gluon plasma phenomenology from anisotropic lattice QCD  

E-Print Network [OSTI]

The FASTSUM collaboration has been carrying out simulations of N_f=2+1 QCD at nonzero temperature in the fixed-scale approach using anisotropic lattices. Here we present the status of these studies, including recent results for electrical conductivity and charge diffusion, and heavy quarkonium (charm and beauty) physics.

Jon-Ivar Skullerud; Gert Aarts; Chris Allton; Alessandro Amato; Yannis Burnier; P. Wynne M. Evans; Pietro Giudice; Simon Hands; Tim Harris; Aoife Kelly; Seyong Kim; Maria Paola Lombardo; Mehmet B. Oktay; Alexander Rothkopf; Sinad M. Ryan

2014-12-30T23:59:59.000Z

246

Corrosion of Ferritic-Martensitic Steels in Steam and Supercritical Water Jeremy Bischoffa, Arthur T. Mottaa, Chad Eichfeldb, Robert J. Comstockc, Guoping Caod, Todd  

E-Print Network [OSTI]

Corrosion of Ferritic-Martensitic Steels in Steam and Supercritical Water Jeremy Bischoffa, Arthur Corrosion tests were performed in steam and supercritical water at 500°C for two ferritic- martensitic alloys: HCM12A and NF616. The corrosion kinetics for the two alloys are similar in both environments

Motta, Arthur T.

247

Corrosion of ferriticmartensitic steels in steam and supercritical water Jeremy Bischoff a,b  

E-Print Network [OSTI]

Corrosion of ferritic­martensitic steels in steam and supercritical water Jeremy Bischoff a: Available online xxxx a b s t r a c t Corrosion tests were performed in steam and supercritical water at 500 °C for two ferritic­martensitic alloys: HCM12A and NF616. The corrosion kinetics for the two alloys

Motta, Arthur T.

248

Automated, heuristic conversion of plain text bibliographic records to MARC format  

E-Print Network [OSTI]

. ':. : 1 I (0)r D'Oronno, I L Ostwald, F M Shipman, and NF Wallace EBJDfdST (uregrorrug CytD groyhtce mto dyuomtc hyyertezt In N Streitc, A Pork, and J Andrge, ethtors, Hypertezt Concepts, Systems and Apphcanons, pages 153g165 Cainbndpe Uruversity Press...

Kalasapur, Siddarth Subash

2001-01-01T23:59:59.000Z

249

Dissipative cryogenic filters with zero dc resistance Hendrik Bluhma  

E-Print Network [OSTI]

additional capacitors of 10 nF per line, an attenuation of at least 45 dB above 10 MHz can be obtained. Thus requirements also occur for flux bias lines of super- conducting qubits. Most flux biased qubit experiments cur resistive con- ductor. The low frequency attenuation is increased by adding two discrete capacitors

Moler, Kathryn A.

250

ENEA F. Zonca 1 Ballooning Transformation  

E-Print Network [OSTI]

based on scale separation. 2 BF introduced by a number of authors in the late 70's (Coppi PRL77, Lee PFBW 77, Glasser PFBW 77, Pegoraro IAEA 78, Connor PRL 78, Dewar NF81) to conveniently treat linear of authors in the late 70's (Coppi PRL77, Lee PFBW 77, Glasser PFBW 77, Pegoraro IAEA 78, Connor PRL 78

Zonca, Fulvio

251

The Status of Mirror Research Based on a Workshop in  

E-Print Network [OSTI]

Construction, Confinement, and Power Balance · Circular coils enable smaller end plugs and higher fields by Deuterium Neutral Beams 10 #12;recent achievements max 60% nf 5x1019 m-3 11 GDT Central Beta Reaches 60.al., J. Fusion Energy, 17, p253 (1998) · [2] J. Pratt & W. Horton, Phys. Plasmas, 13,042513 (2006) · [3

252

Managed by UT-Battelle for the Department of Energy  

E-Print Network [OSTI]

Managed by UT-Battelle for the Department of Energy Neutrino Factory Mercury Containment Concepts V;2 Managed by UT-Battelle for the Department of Energy HPT Workshop, 6 Nov 2008 Outline Neutrino Factory.14 Dimensions in cm #12;6 Managed by UT-Battelle for the Department of Energy HPT Workshop, 6 Nov 2008 NF Hg Jet

McDonald, Kirk

253

Managed by UT-Battelle for the Department of Energy  

E-Print Network [OSTI]

Managed by UT-Battelle for the Department of Energy Design and Operational Features of a Mercury CERN #12;2 Managed by UT-Battelle for the Department of Energy Contributors Tom McManamy, Chief Dec 08 #12;3 Managed by UT-Battelle for the Department of Energy NF-IDS Meeting 15 Dec 08 Outline

McDonald, Kirk

254

INSTITUTE OF PHYSICS PUBLISHING and INTERNATIONAL ATOMIC ENERGY AGENCY NUCLEAR FUSION Nucl. Fusion 43 (2003) 16931709 PII: S0029-5515(03)67272-8  

E-Print Network [OSTI]

INSTITUTE OF PHYSICS PUBLISHING and INTERNATIONAL ATOMIC ENERGY AGENCY NUCLEAR FUSION Nucl. Fusion 43 (2003) 1693­1709 PII: S0029-5515(03)67272-8 Fusion energy with lasers, direct drive targets.iop.org/NF/43/1693 Abstract A coordinated, focused effort is underway to develop Laser Inertial Fusion Energy

Ghoniem, Nasr M.

255

Stereoselective Total Synthesis of (+)-Norrisolide Thomas P. Brady, Sun Hee Kim, Ke Wen, and Emmanuel A. Theodorakis*  

E-Print Network [OSTI]

) at highest commercial quality and used without further purification except where noted. Air- and moisture2Cl2) and benzene (PhH) were purified by passage through a bed of activated alumina.1 NF-254) using UV light as the visualizing agent and 10% ethanolic phosphomolybdic acid (PMA) or p

Theodorakis, Emmanuel

256

ALGEBRA LINEAL I 1er Curso de CC. Fisicas. Examen Final. 4 de Febrero de 2005.  

E-Print Network [OSTI]

ALGEBRA LINEAL I 1er Curso de CC. Fisicas. Examen Final. 4 de Febrero de 2005. Apellidos: Nombre aplicacion lineal f : R3 R3 tal que Kerf = Nf x -y = 0 y -z = 0 Imf x + 2y + 3z = 0. 4. Sean L, U y B

Guijarro, Luis

257

Use of Drop-nets for Wild Pig Damage and Disease Abatement  

E-Print Network [OSTI]

pigs were first observed on the ranch in the mid 1990?s. In 2000, NF took ownership of ORR. Bill Hoffmann owns HR. It is unknown when pigs were first observed on ORR or HR. Past wild pig management included drop-nets and corral traps on ORR...

Gaskamp, Joshua Alden

2012-11-15T23:59:59.000Z

258

ISBN 3-938345-05-5 Int. Meeting on Substrate-Integrated Microelectrodes, 2008 1  

E-Print Network [OSTI]

: electrochemical circu- its including for example Warburg impedance show better concordance with experimental data the electrode marked in red in Fig.4(a) 30 min after the addition of a KCl 3M medium, compared to Z of a theoretical RC// circuit with R=10 M and C=100nF. The equivalent electrochemical circuit fitting MEA Z(f) data

Paris-Sud XI, Université de

259

Non-perturbative beta function in three-dimensional electrodynamics  

E-Print Network [OSTI]

We apply the Schrodinger functional method to the Abelian gauge theory in three dimensions with Nf=2 four-component fermions. We find that the calculated beta function does not cross zero in the range of coupling we study. This implies that the theory exhibits confinement and mass generation, rather than a conformal infared regime.

Ohad Raviv; Yigal Shamir; Benjamin Svetitsky

2014-05-27T23:59:59.000Z

260

www.nature.com/naturemethods NATURE METHODS | VOL.5 NO.3 | MARCH 2008  

E-Print Network [OSTI]

Manager: Gerald Coppin For all print and online assistance, please visit www.nature.com/help Purchase NF-kB FoxA2 Xbp1 CRE TATA Ah rE E GR ARETA E RE Oct LXR E HSE S RE BP p53 B RE Pax HIF1c E ts GLI NRF

Cai, Long

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
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261

Tetrahedron Letters,Vo1.26,No.30,pp 3523-3526,1985 0040-4039/85 $3.00 + .OO Printed in Great Britain 61985 Pergamon Press Ltd.  

E-Print Network [OSTI]

-6 days) azide 1 was transformed to triazoline z.ll Flash pyrolysis nf 1 at 450" or 500" gave a mixture of 8, &J, and 11 (approx.50:40:10) in 86%- yield. Pyrolysis of imine fi gave similar results as did

Hudlicky, Tomas

262

Computing with the Lie correspondence Scott H. Murray  

E-Print Network [OSTI]

Computing with the Lie correspondence Scott H. Murray University of Sydney July 30, 2009 #12;Linear: symplectic groups Sp2n(F) Types B and D: orthogonal Types E, F, G: exceptional #12;Almost reductive Lie The Lie algebra of a connected reductive linear algebraic group I sln(F) is almost reductive F has

Murray, Scott H.

263

Available online at www.sciencedirect.com Enzyme and Microbial Technology 42 (2008) 426433  

E-Print Network [OSTI]

and Environmental Engineering Department and Center for Environmental Research and Technology (CE-CERT), University for two commercial cellulases produced by the fungus Trichoderma reesei, a nitrogen analyzer was used can be closed. Application of the NF method revealed that sugars and especially cellobiose strongly

California at Riverside, University of

264

Effects of supplementary feed enzymes on the laying performance and fecal moisture of a commercial incrossbred egg stock  

E-Print Network [OSTI]

offeots of eater treatment of barley and fungal snmpne suyylsmsntation on Che metabolisahle . nf- %he raMonx-' ai-ref&i+ted bf Cha-:perfc~- of -gi ouing- ohkobd:: ?. The authors reported inoreassi-in the msCaboliga&e energy-as a rema& of the addition...

Ibarbia, Ramon Amador

1964-01-01T23:59:59.000Z

265

north-south,100m east-west, 100m  

E-Print Network [OSTI]

the identification of self-sustaining populations. Use of molecular genetic markers can aid in this identification with increasing age of a stand. Thus spatial genetic bubble Materials and Methods For DNA isolation one leaf position of Bolivar Co. (large triangle) population between the Delta NF and Arkansas populations. Other

266

Possibility of c-axis voltage steps for a cuprate superconductor in a resonant cavity I. Tornes* and D. Stroud  

E-Print Network [OSTI]

, when driven by currents parallel to the c axis, behave like stacks of underdamped Josephson junctions's in stacks of artificial Josephson junctions. We conclude that such steps might be observable with a suitably, 74.25.Nf I. INTRODUCTION Barbara et al.1 have recently shown that underdamped Josephson-junction

Stroud, David

267

Coherence transition of small Josephson junctions coupled to a single-mode resonant cavity: Connection to the Dicke model  

E-Print Network [OSTI]

Coherence transition of small Josephson junctions coupled to a single-mode resonant cavity 5 February 2009 PACS: 74.50.+r 74.25.Nf 85.25.Cp 64.60.Cn Keywords: Josephson junctions properties of a collection of N small Josephson junctions coupled to a single-mode resonant electromagnetic

Stroud, David

268

Nicotine prevents the apoptosis induced by menadione in human lung cancer cells  

SciTech Connect (OSTI)

Approximately 50% of long-term cigarette smokers die prematurely from the adverse effects of smoking, including on lung cancer and other illnesses. Nicotine is a main component in tobacco and has been implicated as a potential factor in the pathogenesis of human lung cancer. However, the mechanism of nicotine action in the development of lung cancer remains largely unknown. In the present study, we designed a nicotine-apoptosis system, by pre-treatment of nicotine making lung cancer cell A549 to be in a physiological nicotine environment, and observed that nicotine promoted cell proliferation and prevented the menadione-induced apoptosis, and exerts its role of anti-apoptosis by shift of apoptotic stage induced by menadione from late apoptotic stage to early apoptotic stage, in which NF-{kappa}B was up-regulated. Interference analysis of NF-{kappa}B in A549 cells showed that knock down of NF-{kappa}B resulted in apoptosis promotion and counteracted the protective effect of nicotine. The findings suggest that nicotine has potential effect in lung cancer genesis, especially in patients with undetectable early tumor development and development of specific NF-{kappa}B inhibitors would represent a potentially exciting new pharmacotherapy for tobacco-related lung cancer.

Zhang Tao [Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072 (China); Lu Heng [Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072 (China); Shang Xuan [Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072 (China); Tian Yihao [Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072 (China); Zheng Congyi [Centre for Type Culture Collection, College of Life Sciences, Wuhan University, Wuhan 430072 (China); Wang Shiwen [Institute of Geriatric Cardiology, General Hospital of PLA, Beijing 100853 (China); Cheng Hanhua [Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072 (China)]. E-mail: hhcheng@whu.edu.cn; Zhou Rongjia [Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072 (China)]. E-mail: rjzhou@whu.edu.cn

2006-04-14T23:59:59.000Z

269

Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Adrenaline increases colon cancer cell proliferation and its resistance to cisplatin. Black-Right-Pointing-Pointer Adrenaline activates NF{kappa}B in a dose dependent manner. Black-Right-Pointing-Pointer NF{kappa}B-miR-155 pathway contributes to cell proliferation and resistance to cisplatin. -- Abstract: Recently, catecholamines have been described as being involved in the regulation of cancer genesis and progression. Here, we reported that adrenaline increased the cell proliferation and decreased the cisplatin induced apoptosis in HT29 cells. Further study found that adrenaline increased miR-155 expression in an NF{kappa}B dependent manner. HT29 cells overexpressing miR-155 had a higher cell growth rate and more resistance to cisplatin induced apoptosis. In contrast, HT29 cells overexpressing miR-155 inhibitor displayed decreased cell proliferation and sensitivity to cisplatin induced cell death. In summary, our study here revealed that adrenaline-NF{kappa}B-miR-155 pathway at least partially contributes to the psychological stress induced proliferation and chemoresistance in HT29 cells, shedding light on increasing the therapeutic strategies of cancer chemotherapy.

Pu, Jun [Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China)] [Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China); Bai, Danna [Department of Cardiology, 323 Hospital of PLA, Xi'an 710054 (China)] [Department of Cardiology, 323 Hospital of PLA, Xi'an 710054 (China); Yang, Xia [Department of Teaching and Medical Administration, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China)] [Department of Teaching and Medical Administration, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China); Lu, Xiaozhao [Department of Nephrology, The 323 Hospital of PLA, Xi'an 710054 (China)] [Department of Nephrology, The 323 Hospital of PLA, Xi'an 710054 (China); Xu, Lijuan, E-mail: 13609296272@163.com [Department of Nephrology, The 323 Hospital of PLA, Xi'an 710054 (China)] [Department of Nephrology, The 323 Hospital of PLA, Xi'an 710054 (China); Lu, Jianguo, E-mail: lujianguo029@yahoo.com.cn [Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China)] [Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an 710038 (China)

2012-11-16T23:59:59.000Z

270

INTRODUCTION Neural intermediate filaments (NIF) containing one or more of  

E-Print Network [OSTI]

INTRODUCTION Neural intermediate filaments (NIF) containing one or more of five different types, NIF possess common structural features, including a conserved alpha-helical central rod domain of NIF in the presence of NF-L (Zackroff et al., 1982; Hisanaga and Hirokawa, 1988; Balin and Lee, 1991

Goldman, Robert D.

271

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research  

E-Print Network [OSTI]

-barrier protection of drinking water, reduction in reverse osmosis membrane fouling due to impurities in impaired, such as reverse osmosis (RO) and nanofiltration (NF), are capable of rejecting most dissolved constituents 2010 Accepted 29 June 2010 Available online 5 August 2010 Keywords: Osmosis Forward osmosis Osmotic

272

1 Removal of Trace Organic Chemicals and Performance of a Novel 2 Hybrid Ultrafiltration-Osmotic Membrane Bioreactor  

E-Print Network [OSTI]

diluted during the process. A reverse osmosis (RO) system is then used to 16 reconcentrate the diluted DS, additional 46 treatment processes such as nanofiltration (NF) or reverse 47 osmosis (RO),3-7 activated carbon from municipal wastewater. The UFO-MBR 10 system uses both ultrafiltration (UF) and forward osmosis (FO

273

Long Josephson junction in a resonant cavity I. Tornes* and D. Stroud  

E-Print Network [OSTI]

Long Josephson junction in a resonant cavity I. Tornes* and D. Stroud Department of Physics Josephson junctions. When a soliton is present in the junction corresponding to a quantum of magnetic flux s : 74.81.Fa, 74.72. h, 74.25.Nf I. INTRODUCTION Josephson junction arrays have now been studied for more

Stroud, David

274

Quark-gluon plasma phenomenology from anisotropic lattice QCD  

E-Print Network [OSTI]

The FASTSUM collaboration has been carrying out simulations of N_f=2+1 QCD at nonzero temperature in the fixed-scale approach using anisotropic lattices. Here we present the status of these studies, including recent results for electrical conductivity and charge diffusion, and heavy quarkonium (charm and beauty) physics.

Skullerud, Jon-Ivar; Allton, Chris; Amato, Alessandro; Burnier, Yannis; Evans, P Wynne M; Giudice, Pietro; Hands, Simon; Harris, Tim; Kelly, Aoife; Kim, Seyong; Lombardo, Maria Paola; Oktay, Mehmet B; Rothkopf, Alexander; Ryan, Sinad M

2015-01-01T23:59:59.000Z

275

TLR9 Immune Evasion by Murine Gammaherpesvirus 68  

E-Print Network [OSTI]

MOI MyD88 NF-?B NLR ODN ORF PAMP pDC PDMS PFU PRRs RIG-I RLRupon infection of cDCs and pDC. The former but not thegenome-positive cells in pDC populations isolated from mice

Pezda, Andrea Christiane

2010-01-01T23:59:59.000Z

276

Ferroelectric and dielectric properties of ferrite-ferroelectric ceramic composites  

SciTech Connect (OSTI)

Particulate composites of ferrite and ferroelectric phases with xNiFe{sub 2}O{sub 4} (NF) and (1 - x)Pb{sub 0.988}(Zr{sub 0.52}Ti{sub 0.48}){sub 0.976}Nb{sub 0.024}O{sub 3} (where x = 2, 10, 20, 30, 50, 70, and 100 wt. %) were prepared in situ by sol-gel method. The presence of a diphase composition was confirmed by X-ray diffraction while the microstructure of the composites was studied by scanning electron microscopy revealing a good mixing of the two phases and a good densification of the bulk ceramics. The dielectric permittivity shows usual dielectric dispersion behavior with increasing frequency due to Maxwell-Wagner interfacial polarization. AC conductivity measurements made in frequency range 1 Hz-1 MHz suggest that the conduction process is due to mixed polaron hopping. The effect of NF phase concentration on the P-E and M-H hysteresis behavior and dielectric properties of the composites was investigated. At low NF concentration a sharp ferro-paraelectric transition peak can be observed at around 360 Degree-Sign C while for higher NF concentrations a trend to a diffuse phase transition occurs. All the composite samples exhibit typical ferromagnetic hysteresis loops, indicating the presence of ordered magnetic structure.

Elena Ciomaga, Cristina; Maria Neagu, Alexandra; Valentin Pop, Mihai; Mitoseriu, Liliana [Faculty of Physics, 'Al. I. Cuza' University of Iasi 700506, Iasi (Romania); Airimioaei, Mirela [Faculty of Chemistry, 'Al. I. Cuza' University of Iasi 700506, Iasi, Romania and Dept. Chemistry and Process Engineering, University of Genoa, P-le Kennedy no. 1, I-16129, Genoa (Italy); Tascu, Sorin [RAMTECH Faculty of Physics, 'Al. I. Cuza' University of Iasi 700506 (Romania); Schileo, Giorgio [Christian Doppler Laboratory for Advanced Ferroic Oxides, Sheffield Hallam University, Howard Street, Sheffield S1 1WB (United Kingdom); Galassi, Carmen [CNR-ISTEC, Via Granarolo no. 64, I-48018 Faenza (Italy)

2013-02-21T23:59:59.000Z

277

Infrared finite coupling in Sudakov resummation  

E-Print Network [OSTI]

New arguments are presented to emphasize the interest of the infrared finite coupling approach to power corrections in the context of Sudakov resummation. The more regular infrared behavior of some peculiar combinations of Sudakov anomalous dimensions, free of Landau singularities at large Nf, is pointed out. A general conflict between the infrared finite coupling and infrared renormalon approaches to power corrections is explained, and a possible resolution is proposed, which makes use of the arbitrariness of the choice of exponentiated constant terms. A simple ansatz for a 'universal' non-perturbative Sudakov effective coupling at large Nf follows naturally from these considerations. In this last version, a new result is presented: the striking emergence of an infrared finite perturbative effective coupling in the Drell-Yan process at large Nf (at odds with the infrared renormalon argument) within the framework of Sudakov resummation for eikonal cross sections of Laenen, Sterman and Vogelsang. Some suggestions for phenomenology at finite Nf, alternative to the shape function approach, are given.

Georges Grunberg

2006-02-06T23:59:59.000Z

278

Exam revision Database Systems Lecture 18  

E-Print Network [OSTI]

,B) and (A,C), fd B C. #12;3 Exam revision Example (coursework 5) · Relation Listing is not in 2NF because1 Exam revision Database Systems Lecture 18 Natasha Alechina Exam revision In This Lecture · Exam format · Main topics · How to revise Exam revision Exam format · Answer three questions out of five

Alechina, Natasha

279

High-numerical aperture holographic data storage Floris M. H. Crompvoets, Frank Schuurmans, Marcello Balistreri, Teus Tukker, Gert 't Hoofi,  

E-Print Network [OSTI]

,4 this technology has gained a lot of attention by the optical storage industry. The promise of HDS-layer Blu-ray Disc (ML-BD)5 and 'Near Field' (NF) recording6. The applications aimed at by the next generation optical storage are for instance professional and personal archiving. A comparison of the overall

Stallinga, Sjoerd

280

Reflective Cracking Study: First-level Report on Laboratory Shear Testing  

E-Print Network [OSTI]

2 and ? 2 ln? 3 and ? 3 lnG lnkcy5 lnn 1 lnn 2 lnNf lnpct559 Figure 4.28: Residual plots of LnG. (Pooled ShearResilient Shear Modulus, G* (lng) The Resilient Shear

Tsai, Bor-Wen; Jones, David; Harvey, John T; Monismith, Carl L.; Guada, I.; Signore, J,

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

JOURNAL OF LIGHTWAVE TECHNOLOGY, VOL. 31, NO. 19, OCTOBER 1, 2013 3181 Noise Figure in Near-Infrared Amorphous and  

E-Print Network [OSTI]

JOURNAL OF LIGHTWAVE TECHNOLOGY, VOL. 31, NO. 19, OCTOBER 1, 2013 3181 Noise Figure in Near-Infrared, Senior Member, IEEE Abstract--The noise figures (NF) of near-infrared (near-IR) amorphous silicon (a Amorphous and Mid-Infrared Crystalline Silicon Optical Parametric Amplifiers Jichi Ma and Sasan Fathpour

Fathpour, Sasan

282

Electromagnetic corrections to light hadron masses  

E-Print Network [OSTI]

At the precision reached in current lattice QCD calculations, electromagnetic effects are becoming numerically relevant. We will present preliminary results for electromagnetic corrections to light hadron masses, based on simulations in which a $\\mathrm{U}(1)$ degree of freedom is superimposed on $N_f=2+1$ QCD configurations from the BMW collaboration.

A. Portelli; S. Drr; Z. Fodor; J. Frison; C. Hoelbling; S. D. Katz; S. Krieg; T. Kurth; L. Lellouch; T. Lippert; K. K. Szab; A. Ramos

2011-01-12T23:59:59.000Z

283

Computational investigation of structured shocks  

E-Print Network [OSTI]

. Grujicic, W.C. Bell and B. Pandurangan Department of Mechanical Engineering, Clemson University, Clemson, Composite materials, Wave propagation, Mechanical shock, Metal matrix composites, Structured shocks, Dynamic Detonation Explosives Shallow-Buried in Soil" Contract Number W911NF-06-2-0042. Structured shocks in MMCs 469

Grujicic, Mica

284

The effects of ethylenediurea and sodium erythorbate on photosynthetic function of ozone-exposed loblolly pine seedlings  

E-Print Network [OSTI]

-top chambers in east Texas for one growing season beginning in April 1994 while being exposed to either sub-ambient (CF), approximate ambient (NF), 1.5Y,, 2.OX, or 2.5X ambient ozone levels. Net photosynthesis (A), stomatal conductance (g), and chloroplast...

Kuehler, Eric Anthony

1995-01-01T23:59:59.000Z

285

Nesting-based Relational-to-XML Schema Translation  

E-Print Network [OSTI]

Nesting-based Relational-to- XML Schema Translation Dongwon Lee Murali Mani Frank Chiu Wesley W Proposed Techniques Flat Translation (FT) Nesting-based Translation (NeT) Translation using InclusionDB'01 Nesting Nested relational model: allows non-1NF Nest operator: nesting on column X collects all

Lee, Dongwon

286

Timed CSP and Object-Z John Derrick  

E-Print Network [OSTI]

Timed CSP and Object-Z John Derrick Computing Laboratory, University of Kent, Canterbury, CT2 7NF a simple integration of timed CSP and Object-Z. Following existing work, the components in such an inte- gration are written as either Object-Z classes, or timed CSP processes, and are combined together using

Kent, University of

287

On Dynamic Vehicle Routing with Time Constraints Shaunak D. Bopardikar Stephen L. Smith Francesco Bullo  

E-Print Network [OSTI]

] and in [12]. Both of these two references deal with a problem which is essentially a dual of the one we work supported in part by NSF Award CPS- 1035917 and ARO Award W911NF-11-1-0092. S. D. Bopardikar

Bullo, Francesco

288

BREAST CANCER GROUP WOMEN'S HEALTH INTERDISCIPLINARY  

E-Print Network [OSTI]

BREAST CANCER GROUP May 2009 WOMEN'S HEALTH INTERDISCIPLINARY RESEARCH CENTER [WHIRC] #12;2 Table: Breast Cancer Research and Treatment 4 Basic/Translational Research Carcinogenesis and Signaling Group 5R) Signaling in Breast Cancer 6 NF-B Family of Transcription Factors in Breast Cancer 7 Transgenic Mouse

Spence, Harlan Ernest

289

Nutrition, digestive system and digestion specificity in phytophagous bats  

E-Print Network [OSTI]

Nutrition, digestive system and digestion specificity in phytophagous bats NF Zhukova Schmalhausen arisen as to how the feeding and digestion specificity is revealed in phytophagous bats, and how the entire order specificity affects these processes. To tackle these issues, the digestive system

Boyer, Edmond

290

OSP WEEKLY FUNDING BULLETIN Volume 5, Issue 33 August 15, 2011  

E-Print Network [OSTI]

(MRI) (modification) Solicitation No. W911NF-11-R-0011CFDA No. Due Date: White Papers: 14 September Solicitation No. DARPA-BAA-11-65 CFDA No. 12.910 Due Date: 9 August 2012 http Center CFDA Number 84.326J Solicitation No. ED-GRANTS-080911-002 CFDA No. 84.326 Due Date: 8 September

Alabama in Huntsville, University of

291

OSP WEEKLY FUNDING BULLETIN Volume 5, Issue 44 October 31, 2011  

E-Print Network [OSTI]

-BAA-11-60 CFDA No. 12.910 Due Date: 2 December 2011 http://www07.grants and Development Program (modification) Solicitation No. W911NF-12-R-0001 CFDA No. 12.630 Due Date: White Papers-AFOSR-2012-02 CFDA No. 12.800 Due Date: 23 November 2012 http://www07.grants

Alabama in Huntsville, University of

292

Adsorption of small organic solutes from beet distillery condensates on reverse-osmosis membranes: consequences on the process performances  

E-Print Network [OSTI]

at the fermentation stage. However, transfer mechanisms through dense NF and RO membranes are still not well of the sorption isotherms of five target inhibitory compounds (acetic and butanoic acids, furfural, 2-phenethyl alone as well as mixed in order to evaluate the competition effects. Results reveal that acetic acid

Boyer, Edmond

293

Mercury Beam Dump Simulations Tristan Davenne Ottone Caretta Chris Densham  

E-Print Network [OSTI]

Mercury Beam Dump Simulations Tristan Davenne Ottone Caretta Chris Densham STFC Rutherford Appleton Laboratory, UK 1st joint meeting of EUROnu WP2 (Superbeam) and NF-IDS target 15-17 December-2008 #12;Mercury beam dump design from NUFACT Feasibility Study #12;Peter Loveridge, November-2008 Mercury beam dump

McDonald, Kirk

294

Mysteries of the lightest nuclear systems R. Lazauskas,  

E-Print Network [OSTI]

NF,..), however nuclear binding energies being strongly correlated does not permit to form a fullMysteries of the lightest nuclear systems R. Lazauskas, CEA DAM/DIF/DPTA/SPN, B.P. 12, Bruy In this contribution current advances and challenge in low energy few- nucleon scattering problem are discussed. Some

Boyer, Edmond

295

2012NatureAmerica,Inc.Allrightsreserved. Nature GeNetics ADVANCE ONLINE PUBLICATION  

E-Print Network [OSTI]

GWASdatasetidentifiedexoDNase,NF-kBsignalingandmitochondrialdysfunctionasbiologicalprocessesrelatedto timingofmenopause. RESULTS In our discovery stage of 38,968 women with natural menopause aged 4060 (Supplementary in effect size for the 20 SNPs in retrospectively and prospectively col- lected menopause age, and found at natural menopause in women from the Women's Genome Health Study (WGHS). For early meno- pause, we compared

Nyholt, Dale R.

296

KT McDonald Muon Accelerator Program DoE Review (FNAL) August 30, 2012 1 Target and Absorbers  

E-Print Network [OSTI]

, 2012 2 Mission Target: Maximum production of of energies ~ 100-400 MeV from a 4-MW proton beam (E: Absorb primary proton beam in liquid-metal pool. Absorb secondary particles in He-gas-cooled tungsten In the IDS-NF costing scenario, the Target System includes the production target and the magnetized pion

McDonald, Kirk

297

PROF. WILLIAM M. ARMSTRONG Education MinisterEileen Dailly alnnouncedTues-  

E-Print Network [OSTI]

and Smelting Co. on thedesign of plants in Vancouver andof an iron ore smelter in Kimberley,B.C. Prof. Armstrongis a member of the copper andsteel Please turn to Page Four See MfNfSTER REQUESTS REPORTSVol. 20, No

Farrell, Anthony P.

298

HES5 silencing is an early and recurrent change in prostate tumourigenesis  

E-Print Network [OSTI]

potential effector mechanism of HES5 silencingERC-14-0454. http://erc.endocrinology-journals.org DOI: 10.1530/ERC-14-0454 q 2015 The authors Printed in Great Britainmatics/btu049) Austin DW, Allen MS, McCollum JM, Dar RD, Wilgus JR, Sayler GS, Samatova NF...

Massie, Charles E; Spiteri, Inmaculada; Ross-Adams, Helen; Luxton, Hayley; Kay, Jonathan; Whitaker, Hayley C; Dunning, Mark J; Lamb, Alastair\tD; Ramos-Montoya, Antonio; Brewer, Daniel\tS; Cooper, Colin S.; Eeles, Rosalind; UK\tProstate\tICGC\tGroup; Warren, Anne\tY; Tavar, Simon; Neal, David\tE.; Lynch, Andy G

2015-01-05T23:59:59.000Z

299

NYPA/TH!NK Clean Commute Program Final Report - Inception through December 2004  

SciTech Connect (OSTI)

The Clean Commute Program uses TH!NK city electric vehicles from Ford Motor Companys electric vehicle group, TH!NK Mobility, to demonstrate the feasibility of using electric transportation in urban applications. Suburban New York City railroad commuters use the TH!NK city vehicles to commute from their private residences to railroad stations, where they catch commuter trains into New York City. Electric vehicle charging infrastructure for the TH!NK city vehicles is located at the commuters private residences as well as seven train stations. Ford leased at total of 97 TH!NK city electric vehicles to commuters from Westchester, Putnam, Rockland, Queens, Nassau, and Suffolk counties for $199 per month. First Clean Commute Program vehicle deliveries occurred late in 2001, with data collection commencing in February 2002. Through May, 2004, 24 of the lessees have returned their vehicles to Ford and no longer participate in the Clean Commute Program. Reasons given for leaving the Program include relocation out of the Program area, change in employment status, change in commuting status, and, in a few cases, dissatisfaction with the vehicle. Additionally, 13 vehicles were returned to Ford when the lease was completed. In August 2002, Ford announced that it was ceasing production of the TH!NK city and would not extend any TH!NK city leases. Mileage accumulation dropped in the last quarter of the program as vehicle leases were returned to Ford. The impact of the program overall was significant as participants in the Clean Commute Program drove their vehicles over 406,074 miles, avoiding the use of over 18,887 gallons of gasoline. During the active portion of the program, the TH!NK city vehicles were driven an average of between 180 and 230 miles per month. Over 95% of all trips taken with the TH!NK city vehicles replaced trips previously taken in gasoline vehicles. This report covers the period from Program inception through December 2004.

James Francfort; Don Karner

2005-11-01T23:59:59.000Z

300

Baseline Environmental Analysis Report for the K-1251 Barge Facility at the East Tennessee Technology Park, Oak Ridge, Tennessee  

SciTech Connect (OSTI)

This report documents the baseline environmental conditions of the U. S. Department of Energy's (DOE's) K-1251 Barge Facility, which is located at the East Tennessee Technology Park (ETTP). DOE is proposing to lease the facility to the Community Reuse Organization of East Tennessee (CROET). This report provides supporting information for the use, by a potential lessee, of government-owned facilities at ETTP. This report is based upon the requirements of Sect. 120(h) of the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The lease footprint is slightly over 1 acre. The majority of the lease footprint is defined by a perimeter fence that surrounds a gravel-covered area with a small concrete pad within it. Also included is a gravel drive with locked gates at each end that extends on the east side to South First Avenue, providing access to the facility. The facility is located along the Clinch River and an inlet of the river that forms its southern boundary. To the east, west, and north, the lease footprint is surrounded by DOE property. Preparation of this report included the review of government records, title documents, historic aerial photos, visual and physical inspections of the property and adjacent properties, and interviews with current and former employees involved in the operations on the real property to identify any areas on the property where hazardous substances and petroleum products or their derivatives and acutely hazardous wastes were known to have been released or disposed. Radiological surveys were conducted and chemical samples were collected to assess the facility's condition.

Van Winkle J.E.

2007-08-24T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Silencing MR-1 attenuates inflammatory damage in mice heart induced by AngII  

SciTech Connect (OSTI)

Myofibrillogenesis regulator-1(MR-1) can aggravate cardiac hypertrophy induced by angiotensin(Ang) II in mice through activation of NF-{kappa}B signaling pathway, and nuclear transcription factor (NF)-{kappa}B and activator protein-1(AP-1) regulate inflammatory and immune responses by increasing the expression of specific inflammatory genes in various tissues including heart. Whether inhibition of MR-1 expression will attenuate AngII-induced inflammatory injury in mice heart has not been explored. Herein, we monitored the activation of NF-{kappa}B and AP-1, together with expression of pro-inflammatory of interleukin(IL)-6, tumor necrosis factor(TNF)-{alpha}, vascular-cell adhesion molecule (VCAM)-1, platelet endothelial cell adhesion molecule (PECAM), and inflammatory cell infiltration in heart of mice which are induced firstly by AngII (PBS),then received MR-1-siRNA or control-siRNA injecting. We found that the activation of NF-{kappa}B and AP-1 was inhibited significantly, together with the decreased expression of IL-6, TNF-{alpha}, VCAM-1, and PECAM in AngII-induced mice myocardium in MR-1-siRNA injection groups compared with control-siRNA injecting groups. However, the expression level of MR-1 was not an apparent change in PBS-infused groups than in unoperation groups, and MR-1-siRNA do not affect the expression of MR-1 in PBS-infused mice. Our findings suggest that silencing MR-1 protected mice myocardium against inflammatory injury induced by AngII by suppression of pro-inflammatory transcription factors NF-{kappa}B and AP-1 signaling pathway.

Dai, Wenjian [Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Key Lab of Antibiotic Biotechnology, Ministry of Health, Beijing 100050 (China) [Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Key Lab of Antibiotic Biotechnology, Ministry of Health, Beijing 100050 (China); Hunan Environment-Biological Polytechnic College, Hengyang Hunan 421005 (China); Chen, Haiyang [Hunan Environment-Biological Polytechnic College, Hengyang Hunan 421005 (China)] [Hunan Environment-Biological Polytechnic College, Hengyang Hunan 421005 (China); Jiang, Jiandong [Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Key Lab of Antibiotic Biotechnology, Ministry of Health, Beijing 100050 (China)] [Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Key Lab of Antibiotic Biotechnology, Ministry of Health, Beijing 100050 (China); Kong, Weijia, E-mail: wjkong894@sohu.com [Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Key Lab of Antibiotic Biotechnology, Ministry of Health, Beijing 100050 (China)] [Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Key Lab of Antibiotic Biotechnology, Ministry of Health, Beijing 100050 (China); Wang, Yiguang, E-mail: wangyh456@yahoo.com.cn [Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Key Lab of Antibiotic Biotechnology, Ministry of Health, Beijing 100050 (China)] [Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Key Lab of Antibiotic Biotechnology, Ministry of Health, Beijing 100050 (China)

2010-01-15T23:59:59.000Z

302

High glucose induces inflammatory cytokine through protein kinase C-induced toll-like receptor 2 pathway in gingival fibroblasts  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer High glucose significantly induced TLR2 expression in gingival fibroblasts. Black-Right-Pointing-Pointer High glucose increased NF-{kappa}B p65 nuclear activity, IL-1{beta} and TNF-{alpha} levels. Black-Right-Pointing-Pointer PKC-{alpha}/{delta}-TLR2 pathway is involved in periodontal inflammation under high glucose. -- Abstract: Toll-like receptors (TLRs) play a key role in innate immune response and inflammation, especially in periodontitis. Meanwhile, hyperglycemia can induce inflammation in diabetes complications. However, the activity of TLRs in periodontitis complicated with hyperglycemia is still unclear. In the present study, high glucose (25 mmol/l) significantly induced TLR2 expression in gingival fibroblasts (p < 0.05). Also, high glucose increased nuclear factor kappa B (NF-{kappa}B) p65 nuclear activity, tumor necrosis factor-{alpha} (TNF-{alpha}) and interleukin-l{beta} (IL-1{beta}) levels. Protein kinase C (PKC)-{alpha} and {delta} knockdown with siRNA significantly decreased TLR2 and NF-{kappa}B p65 expression (p < 0.05), whereas inhibition of PKC-{beta} had no effect on TLR2 and NF-{kappa}B p65 under high glucose (p < 0.05). Additional studies revealed that TLR2 knockdown significantly abrogated high-glucose-induced NF-{kappa}B expression and inflammatory cytokine secretion. Collectively, these data suggest that high glucose stimulates TNF-{alpha} and IL-1{beta} secretion via inducing TLR2 through PKC-{alpha} and PKC-{delta} in human gingival fibroblasts.

Jiang, Shao-Yun, E-mail: jiangshaoyun@yahoo.com [School of Dentistry, Tianjin Medical University, 12 Qi Xiang Tai Street, Heping District, Tianjin 300070 (China)] [School of Dentistry, Tianjin Medical University, 12 Qi Xiang Tai Street, Heping District, Tianjin 300070 (China); Wei, Cong-Cong; Shang, Ting-Ting; Lian, Qi; Wu, Chen-Xuan [School of Dentistry, Tianjin Medical University, 12 Qi Xiang Tai Street, Heping District, Tianjin 300070 (China)] [School of Dentistry, Tianjin Medical University, 12 Qi Xiang Tai Street, Heping District, Tianjin 300070 (China); Deng, Jia-Yin, E-mail: yazhou2991@126.com [School of Dentistry, Tianjin Medical University, 12 Qi Xiang Tai Street, Heping District, Tianjin 300070 (China)] [School of Dentistry, Tianjin Medical University, 12 Qi Xiang Tai Street, Heping District, Tianjin 300070 (China)

2012-10-26T23:59:59.000Z

303

Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice  

SciTech Connect (OSTI)

Traffic related particulate matter air pollution is a risk factor for cardiovascular events; however, the biological mechanisms are unclear. We hypothesize that diesel exhaust (DE) inhalation induces up-regulation of inducible nitric oxide synthase (iNOS), which is known to contribute to vascular dysfunction, progression of atherosclerosis and ultimately cardiovascular morbidity and mortality. Methods: ApoE knockout mice (30-week) were exposed to DE (at 200 {mu}g/m{sup 3} of particulate matter) or filtered-air (control) for 7 weeks (6 h/day, 5 days/week). iNOS expression in the blood vessels and heart was evaluated by immunohistochemistry and western blotting analysis. To examine iNOS activity, thoracic aortae were mounted in a wire myograph, and vasoconstriction stimulated by phenylephrine (PE) was measured with and without the presence of the specific inhibitor for iNOS (1400 W). NF-{kappa}B (p65) activity was examined by ELISA. The mRNA expression of iNOS and NF-{kappa}B (p65) was determined by real-time PCR. Results: DE exposure significantly enhanced iNOS expression in the thoracic aorta (4-fold) and heart (1.5 fold). DE exposure significantly attenuated PE-stimulated vasoconstriction by {approx} 20%, which was partly reversed by 1400 W. The mRNA expression of iNOS and NF-{kappa}B was significantly augmented after DE exposure. NF-{kappa}B activity was enhanced 2-fold after DE inhalation, and the augmented NF-{kappa}B activity was positively correlated with iNOS expression (R{sup 2} = 0.5998). Conclusions: We show that exposure to DE increases iNOS expression and activity possibly via NF-{kappa}B-mediated pathway. We suspect that DE exposure-caused up-regulation of iNOS contributes to vascular dysfunction and atherogenesis, which could ultimately lead to urban air pollution-associated cardiovascular morbidity and mortality. - Highlights: > Exposed ApoE knockout mice (30-week) to diesel exhaust (DE) for 7 weeks. > Examine iNOS expression and activity in the blood vessels and heart. > DE exposure enhanced iNOS protein and mRNA expression in the aorta and heart. > iNOS activity was also increased after DE exposure. > This up-regulation of iNOS may contribute to vascular dysfunction and atherogenesis.

Bai Ni [Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC (Canada); James Hogg Research Centre, Providence Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC (Canada); Kido, Takashi [James Hogg Research Centre, Providence Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC (Canada); Kavanagh, Terrance J.; Kaufman, Joel D.; Rosenfeld, Michael E. [Department of Occupational and Environmental Health, University of Washington, Seattle, WA (United States); Breemen, Cornelis van [Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC (Canada); Eeden, Stephan F. van, E-mail: Stephan.vanEeden@hli.ubc.ca [James Hogg Research Centre, Providence Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC (Canada)

2011-09-01T23:59:59.000Z

304

Low-energy neutrino factory design  

SciTech Connect (OSTI)

The design of a low-energy (4 GeV) neutrino factory (NF) is described, along with its expected performance. The neutrino factory uses a high-energy proton beam to produce charged pions. The {pi}{sup {+-}} decay to produce muons ({mu}{sup {+-}}), which are collected, accelerated, and stored in a ring with long straight sections. Muons decaying in the straight sections produce neutrino beams. The scheme is based on previous designs for higher energy neutrino factories, but has an improved bunching and phase rotation system, and new acceleration, storage ring, and detector schemes tailored to the needs of the lower energy facility. Our simulations suggest that the NF scheme we describe can produce neutrino beams generated by {approx} 1.4 x 10{sup 21} {mu}{sup +} per year decaying in a long straight section of the storage ring, and a similar number of {mu}{sup -} decays.

Ankenbrandt, C.; /Fermilab /MUONS Inc., Batavia; Bogacz, S.A.; /Jefferson Lab; Bross, A.; Geer, S.; Johnstone, C.; Neuffer, D.; Popovic, M.; /Fermilab

2009-07-01T23:59:59.000Z

305

Quantum Phase Transition in a Graphene Model  

E-Print Network [OSTI]

We present results for the equation of state of a graphene-like model in an effort to understand the properties of its quantum phase transition. The N_f fermion species interact through a three dimensional instantaneous Coulomb potential. Since there are no reliable analytical tools that work for all values of N_f and the coupling constant g, we rely on Monte Carlo simulations to calculate the critical properties of the model near the phase transition. We consider the four-component formulation for the fermion fields, which arises naturally as the continuum limit of the staggered fermion construction in (2+1) dimensions. In the limit of infinitely strong Coulomb interaction, the system undergoes a quantum phase transition at a critical number of fermion species N_fc ~ 4.7. We also calculate the values of the critical exponents at the quantum phase transition.

Simon Hands; Costas Strouthos

2008-08-20T23:59:59.000Z

306

Design and Syntheses of Dyes for Biological Applications  

E-Print Network [OSTI]

NF2BN N NH N HN N F2B N 5 N NH N HN NF2B N N F2B N 6 mes mes N NH N HN R R R R R = N B F2 N N F2B N 7 Figure 1.6 Continued. 15 Lindsey investigated the potential of systems like 1 as ?optoelectronic gates... by their inherent hydrophobicities. N BF2 N R = 8 !abs max 504 nm !em max 544 nm ETE 97 % R N BF2 N R N B F2 N O N H HO2C 9 !abs max 504 nm !em max 545 nm ETE 94 % R N B F2 N O SucO OMeMeO 10 !abs max 504 nm !em max 632 nm...

Thivierge, Cliferson

2012-07-16T23:59:59.000Z

307

Infra-red divergences in the large-N expansion  

E-Print Network [OSTI]

We investigate a vectorial O(N) model with a generic nearest-neighbor interaction W(\\bsigma_i\\cdot \\bsigma_j) (depending on {\\cal N} tunable parameters), a Yukawa (and Gross Neveu) model with N_f fermions at finite temperature and the vectorial \\phi^6 model, in the large N (N_f) limit. All this models exhibit a Mean Field critical point for N=\\infinity. When 1/N fluctuations are included, infra red divergences appear near the critical point. In the framework of a generalized 1/N expansion we show that these divergences are related to a universal crossover mechanism between the Mean Field universality class (N=\\infinity) and the nonclassical one for N<\\infinity. For the generic nearest-neighbor interaction multicritical points are also investigated.

Bortolo Matteo Mognetti

2007-03-20T23:59:59.000Z

308

The influence of educational expenditures on educational attainment levels: a comparison of rural, urban, suburban, and metropolitan counties in the Southwest and Northeast United States  

E-Print Network [OSTI]

. The $1 la 0 0 V ro al 0 0 V c' I rrl cfog 0 I 4 a al 4 td 4J 0 ai 0 g td Ql QI j1 U 0 Ja V CQ Ot '0 Ql 4J V Ql QI c' 0 Ql QJ IO 0 Ql 'Cl u Qj 4J 4 0 QJ 0 0 0 cd Ch IJ 0 0 Ql al 8 ttl 0 4J 0 0 CJ al '0 4. J aj 4... Lelsud l'. Pnsuor'h Submll. ted to the Grsdusto Colleg. of . 'uses A ll Uuiu. I. Jtv fu f srti!" . . ul TJ llm! ot. nf tie rcqv'rts! nt for the degree nf J1ASTER OF SCT !ECE December J. 97h Pic Jor S!!bject: So-ioJ! At- THE INFLUENCE OF EDUCATIONAL...

Bosworth, Leland D

2012-06-07T23:59:59.000Z

309

Mott multicriticality of Dirac electrons in graphene  

E-Print Network [OSTI]

We study the multicritical behavior for the semimetal-insulator transitions on graphene's honeycomb lattice using the Gross-Neveu-Yukawa effective theory with two order parameters: the SO(3) (Heisenberg) order parameter describes the antiferromagnetic transition, and the $\\mathbb{Z}_2$ (Ising) order parameter describes the transition to a staggered density state. Their coupling induces multicritical behavior which determines the structure of the phase diagram close to the multicritical point. Depending on the number of fermion flavors $N_f$ and working in the perturbative regime in vicinity of three (spatial) dimensions, we observe first order or continuous phase transitions at the multicritical point. For the graphene case of $N_f=2$ and within our low order approximation, the phase diagram displays a tetracritical structure.

Classen, Laura; Janssen, Lukas; Scherer, Michael M

2015-01-01T23:59:59.000Z

310

Superconducting and Spinning Non-Abelian Flux Tubes  

E-Print Network [OSTI]

We find new non-Abelian flux tube solutions in a model of $N_f$ scalar fields in the fundamental representation of SU(N)xU(1) with $N \\leq N_f$ (the ``extended non-Abelian Higgs model''), and study their main properties. Among the solutions there are spinning strings as well as superconducting ones. The solutions exist only in a non trivial domain of the parameter space defined by the ratio between the SU(N) and U(1) coupling constants, the scalar self-interaction coupling constants, the magnetic fluxes (Abelian as well as non-Abelian) and the ``twist parameter'' which is a non-trivial relative phase of the Higgs fields.

Y. Brihaye; Y. Verbin

2008-04-11T23:59:59.000Z

311

Design and development of a high-temperature sodium compatibility testing facility  

SciTech Connect (OSTI)

The use of advanced alloys within sodium-cooled fast reactors (SFRs) has been identified as a means of increasing plant efficiency and reducing construction costs. In particular, alloys such as NF-616, NF-709 and HT-UPS are promising because they exhibit greater strength than traditional structural materials such as 316-SS. However, almost nothing is known about the sodium compatibility of these new alloys. Therefore, research taking place at the Univ. of Wisconsin-Madison is focused on studying the effects of sodium corrosion on these materials under prototypic SFR operating conditions (600 [ deg. C], V Na=10 [m/s], C 0{approx} 1 [wppm]). This paper focuses on the design and construction of the testing facility with an emphasis on moving magnet pumps (MMPs). Corrosion data from a preliminary 500 [hr] natural convection test will also be presented. (authors)

Hvasta, M. G.; Nolet, B. K.; Anderson, M. H. [Univ. of Wisconsin-Madison, 1500 Engineering Dr., Madison - ERB 841, WI 53705 (United States)

2012-07-01T23:59:59.000Z

312

Webs of Walls  

E-Print Network [OSTI]

Webs of domain walls are constructed as 1/4 BPS states in d=4, N=2 supersymmetric U(Nc) gauge theories with Nf hypermultiplets in the fundamental representation. Web of walls can contain any numbers of external legs and loops like (p,q) string/5-brane webs. We find the moduli space M of a 1/4 BPS equation for wall webs to be the complex Grassmann manifold. When moduli spaces of 1/2 BPS states (parallel walls) and the vacua are removed from M, the non-compact moduli space of genuine 1/4 BPS wall webs is obtained. All the solutions are obtained explicitly and exactly in the strong gauge coupling limit. In the case of Abelian gauge theory, we work out the correspondence between configurations of wall web and the moduli space CP^{Nf-1}.

Minoru Eto; Youichi Isozumi; Muneto Nitta; Keisuke Ohashi; Norisuke Sakai

2005-06-20T23:59:59.000Z

313

Evaluation of high- and low-protein sorghum grains supplemented with lysine and lysine plus threonine as a feed for finishing swine  

E-Print Network [OSTI]

/or methionine content are below the finishing pigs' requirements for these amino acids. Sorghum grain supplemented with these amino acids, either singularly or in combination, plus needed vitamins and minerals should theoretically provide optimum growth..., there was no significant difference in retained nitrogen. The nutritive value of two sorghum grains containing 7. 9 and 11. 8% protein was compared on the basis of rat growth and amino acid analyses by Waggle eX nf. (1966). The high protein sorghum grain had higher...

Kinslow, William Freddie

1972-01-01T23:59:59.000Z

314

Fertilizers for Rice in Texas.  

E-Print Network [OSTI]

LIBRARY, CAMPUS. TEXAS AGRICULTURAL EXPERIMENT STATION 1 BULLETIN NO. 398 , DIVISION OF AGRONOMY FERTILIZERS FOR RICE IN TEXAS GRICULTURAL AND MECHANICAL COLLEGE OF TEXAS T. 0. \\\\TALTON, President STATION DMINISTRATION: A. B. CONNER, M. S... of Agriculture. ***Tm n,,nn-n+;,n "4th thm Cphnnl nf Aon~l~lt~lrp Experiments with fertilizers on rice at Substation No. 4, Texas Agricultural Experiment Station, Beaumont, Texas, show that the soils responded to nitrogen and phosphoric acid, but nitrogen...

Reynolds, E. B. (Elbert Brunner); Wyche, R. H. (Robert Henry)

1929-01-01T23:59:59.000Z

315

VALIDATION DE METHODE D'ETALONNAGE ET EVALUATION DES INCERTITUDES DE MESURE EN ANALYSE  

E-Print Network [OSTI]

'INERIS, organisme accrédité ISO/CEI/17025, certifié ISO 9001 et reconnu BPL, a pour mission la maîtrise des risques mesure exposés dans ce document. Abstract : INERIS, a certified (ISO 9001) and accredited (ISO/CEI 17025 norme NF ISO 17993 [5]. Le diagramme d'Ishikawa de l'analyse du processus de mesure des HAP par CLHP

Boyer, Edmond

316

Results on the disconnected contributions for hadron structure  

E-Print Network [OSTI]

We present results on the disconnected contributions to three point functions entering in studies of hadron structure. We use $N_F = 2+1+1$ twisted mass fermions and give a detailed description on the results of the nucleon {\\sigma}-terms, isoscalar axial charge and first moments of bare parton distributions for a range of pions masses. In addition we give the {\\sigma}-terms and the computations are performed using QUDA code implemented on GPUs.

Constantia Alexandrou; Martha Constantinou; Vincent Drach; Kyriakos Hadjiyiannakou; Karl Jansen; Giannis Koutsou; Alejandro Vaquero

2014-12-19T23:59:59.000Z

317

Four-nucleon force in chiral effective field theory  

SciTech Connect (OSTI)

We derive the leading contribution to the four--nucleon force within the framework of chiral effective field theory. It is governed by the exchange of pions and the lowest--order nucleon--nucleon contact interaction and includes effects due to the nonlinear pion--nucleon couplings and the pion self interactions constrained by the chiral symmetry of QCD. The resulting 4NF does not contain any unknown parameters and can be tested in future few--and many--nucleon studies.

Evgeny Epelbaum

2005-10-25T23:59:59.000Z

318

Assessment of energetic costs of AhR activation by ?-naphthoflavone in rainbow trout (Oncorhynchus mykiss) hepatocytes using metabolic flux analysis  

SciTech Connect (OSTI)

Exposure to environmental contaminants such as activators of the aryl hydrocarbon receptor (AhR) leads to the induction of defense and detoxification mechanisms. While these mechanisms allow organisms to metabolize and excrete at least some of these environmental contaminants, it has been proposed that these mechanisms lead to significant energetic challenges. This study tests the hypothesis that activation of the AhR by the model agonist ?-naphthoflavone (?NF) results in increased energetic costs in rainbow trout (Oncorhynchus mykiss) hepatocytes. To address this hypothesis, we employed traditional biochemical approaches to examine energy allocation and metabolism including the adenylate energy charge (AEC), protein synthesis rates, Na{sup +}/K{sup +}-ATPase activity, and enzyme activities. Moreover, we have used for the first time in a fish cell preparation, metabolic flux analysis (MFA) an in silico approach for the estimation of intracellular metabolic fluxes. Exposure of trout hepatocytes to 1 ?M ?NF for 48 h did not alter hepatocyte AEC, protein synthesis, or Na{sup +}/K{sup +}-ATPase activity but did lead to sparing of glycogen reserves and changes in activities of alanine aminotransferase and citrate synthase suggesting altered metabolism. Conversely, MFA did not identify altered metabolic fluxes, although we do show that the dynamic metabolism of isolated trout hepatocytes poses a significant challenge for this type of approach which should be considered in future studies. - Highlights: Energetic costs of AhR activation by ?NF was examined in rainbow trout hepatocytes. Metabolic flux analysis was performed on a fish cell preparation for the first time. Exposure to ?NF led to sparing of glycogen reserves and altered enzyme activities. Adenylate energy charge was maintained despite temporal changes in metabolism.

Nault, Rance, E-mail: naultran@msu.edu [Ottawa-Carleton Institute of Biology, Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, K1N 6N5 (Canada); Abdul-Fattah, Hiba [Ottawa-Carleton Institute of Biology, Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, K1N 6N5 (Canada); Mironov, Gleb G.; Berezovski, Maxim V. [Ottawa-Carleton Institute of Biology, Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, K1N 6N5 (Canada); Department of Chemistry, University of Ottawa, Ottawa, Ontario, K1N 6N5 (Canada); Moon, Thomas W. [Ottawa-Carleton Institute of Biology, Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, K1N 6N5 (Canada)

2013-08-15T23:59:59.000Z

319

ENEA-UCI Structures of the low frequency Alfven continuous spectrum 1 Structures of the low frequency Alfven  

E-Print Network [OSTI]

(KTI) gap (L. Chen 2007, NF 47 S727) Diamagnetic drift: KBM (H. Biglari, et al. 1991, PRL 67 3681) Thermal ion compress.: BAE (W.W. Heidbrink, et al. 1993, PRL 71 855) Ti and wave-part. resonances: AITG Alfv´en continuous spectrum 5 R.Nazikian,etal.06,PRL96,105006 R. Nazikian, et al. 06, PRL 96, 105006

Zonca, Fulvio

320

Dysregulation of nuclear factor kappa B activity and osteopontin expression in oxidant-induced atherogenesis  

E-Print Network [OSTI]

?????????????????.. 14 Fig. 3 A schematic representation of NF-? B activation????????.. 16 Fig. 4 A schematic representation of the allylamine model??????.? 24 Fig. 5 Metabolism and toxicity of acrolein?????????????.. 26 Fig. 6 Metabolism and toxicity of hydrogen... to acrolein and hydrogen peroxide in the vessel wall by semicarbazide-sensitive amine oxidase (SSAO). 24 Early experiments by Boor and Nelson demonstrated ?vigorous? acrolein production in aortic homogenates isolated from rats and humans, a levels six times...

Williams, Edward Spencer

2004-09-30T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

The trees, shrubs, vines and ground covers of Austin, Texas: a study of the cultivated plant materials in a central Texas landscape  

E-Print Network [OSTI]

of new or existing nursery sites might be evaluated for f'ield or container grown plants by referring to edaphic or climatological data. Landscape planners and park managers might utilize the data obtained to develop more diverse, more stable... Physiograohy nf the Study Area The late B. C. Tharp, botanist, once remarked, "Austin occupies a i7ost strategic position in being situated on a line where eastern and western floras meet" (96). while this statement refers to. natural vegetation...

Cole, Deborah Elaine

1976-01-01T23:59:59.000Z

322

Universidad Autonoma de Madrid Algebra Lineal. Curso 2010-11 Matematicas  

E-Print Network [OSTI]

Universidad Autonoma de Madrid Algebra Lineal. Curso 2010-11 Matematicas ALGEBRA LINEAL Hoja 7 respecto de B) coincide con la aplicacion lineal f(x, y, z) = x - y. Encontrar bases de Ker(f) = N(f) y de Im f. Comprobar la formula de la dimension. 2. Sea f : M22 R3 la aplicacion lineal dada por f

Gonzlez Dez, Gabino

323

Universidad Autonoma de Madrid Algebra Lineal. Curso 2011-12 Matematicas  

E-Print Network [OSTI]

Universidad Autonoma de Madrid Algebra Lineal. Curso 2011-12 Matematicas ALGEBRA LINEAL Hoja 8 respecto de B) coincide con la aplicacion lineal f(x, y, z) = x - y. Encontrar bases de Ker(f) = N(f) y de Im f. Comprobar la formula de la dimension. 2. Sea f : M22 R3 la aplicacion lineal dada por f

Gonzlez Dez, Gabino

324

Spring 2008 Qualifier -Part II 12 minute questions 11) Consider a parallel LCR circuit maintained at a temperature T >> h kB LC( ). Use  

E-Print Network [OSTI]

= vs 2 = constant , and assuming a spherically symmetric density distribution = r( ) = C r2 , find C in terms of vs and G. #12;14) A positron e+ is moving with a kinetic energy equal to its rest energy-dimensional gas of N free elections at T = 0 K is U0 = 3 5 NF , where F is the Fermi energy. #12;18) A straight

Yavuz, Deniz

325

The electric dipole moment of the nucleon from simulations at imaginary vacuum angle theta  

E-Print Network [OSTI]

We compute the electric dipole moment of proton and neutron from lattice QCD simulations with N_f=2 flavors of dynamical quarks at imaginary vacuum angle theta. The calculation proceeds via the CP odd form factor F_3. A novel feature of our calculation is that we use partially twisted boundary conditions to extract F_3 at zero momentum transfer. As a byproduct, we test the QCD vacuum at nonvanishing theta.

R. Horsley; T. Izubuchi; Y. Nakamura; D. Pleiter; P. E. L. Rakow; G. Schierholz; J. Zanotti

2008-08-15T23:59:59.000Z

326

Evaluation of Fatigue Resistance in Alaskan Sled Dogs Through Exercise Induced Myocyte Gene Expression  

E-Print Network [OSTI]

Projects Agency, who made this project possible through their funding (Award# W911NF0710552). vi TABLE OF CONTENTS Page ABSTRACT ???????????????????????????. iii ACKNOWLEDGEMENTS ????????????????????? v...., Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest, 113(5): p. 756-763, 2004. 18. Porubsky, P.R., K.P. Battaile, and E.E. Scott , Human cytochrome P450 2E1 structures with fatty acid...

Salazar, Natacha Maria

2012-02-14T23:59:59.000Z

327

A numerical investigation of long waves in the atmosphere produced by flow over various mountain profiles  

E-Print Network [OSTI]

. The wavelengths range from 2000 to 7000 km. With sinusoidal initial streaulines, a study is made nf the ef- fect of a mountain ridge placed at different positions relative to the initial flow. This experiment demonstrates the blocking and splitting action... Upstream from the Trough of the Initial Streamlines. 45 16c. Case Xllc - Pattern of Vorticity after Three Days with the Mountain Placed at the Ridge of the Initial Streamlines. 17. Case XIII - Pattern of Positive Vorticity after Three Days. 48 LIST...

Collins, Ralph Warren

1968-01-01T23:59:59.000Z

328

Sheep Breeding and Feeding.  

E-Print Network [OSTI]

L. J. HART, Chairman WILL A. MILLER, JR. GOVERNING BOARD, STATE SUBSTATIONS ....................................... P L DOWNS President Temple.. .Term expires 1919 ................................. c~ARLE~ ROAAN. vice-hrerid~nf. Austin. .Term..., Inspector T. H. WOLTERS. Inspecfor S. D. PEARCE, Inspector W. M. WICKES, Inspector SUBSTATION NO. 1: Beeville, Bee Count] E. E. BINFORD, B. S., Super~ntendenf SUBSTATION'NO. 2: Troup, Smith Count: W. S. HOTCHKISS, Superintendent SUBSTATION NO. 3...

Jones, J. M. (John McKinley)

1917-01-01T23:59:59.000Z

329

miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohns disease  

SciTech Connect (OSTI)

Highlights: NOD2 is a target gene of miR-122. miR-122 inhibits LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. miR-122 reduces the expression of pro-inflammatory cytokines (TNF-? and IFN-?). miR-122 promotes the release of anti-inflammatory cytokines (IL-4 and IL-10). NF-?B signaling pathway is involved in inflammatory response induced by LPS. -- Abstract: Crohns disease (CD) is one of the two major types of inflammatory bowel disease (IBD) thought to be caused by genetic and environmental factors. Recently, miR-122 was found to be deregulated in association with CD progression. However, the underlying molecular mechanisms remain unclear. In the present study, the gene nucleotide-binding oligomerization domain 2 (NOD2/CARD15), which is strongly associated with susceptibility to CD, was identified as a functional target of miR-122. MiR-122 inhibited LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. NOD2 interaction with LPS initiates signal transduction mechanisms resulting in the activation of nuclear factor ?B (NF-?B) and the stimulation of downstream pro-inflammatory events. The activation of NF-?B was inhibited in LPS-stimulated HT-29 cells pretreated with miR-122 precursor or NOD2 shRNA. The expression of the pro-inflammatory cytokines TNF-? and IFN-? was significantly decreased, whereas therelease of the anti-inflammatory cytokines IL-4 and IL-10 was increased in LPS-stimulated HT-29 cells pretreated with miR-122 precursor, NOD2 shRNA or the NF-?B inhibitor QNZ. Taken together, these results indicate that miR-122 and its target gene NOD2 may play an important role in the injury of intestinal epithelial cells induced by LPS.

Chen, Yu; Wang, Chengxiao; Liu, Ying; Tang, Liwei; Zheng, Mingxia [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China); Xu, Chundi [Department of Pediatrics, Ruijin affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China)] [Department of Pediatrics, Ruijin affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China); Song, Jian, E-mail: jiansongkxy@126.com [Department of Gastroenterology, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Gastroenterology, Jiangwan Hospital of Shanghai, Shanghai 200434 (China); Meng, Xiaochun [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)

2013-08-16T23:59:59.000Z

330

R u t c o r R e p o r t  

E-Print Network [OSTI]

hereditary if ISub(G) ` P for every G 2 P . For a set Z of graphs denote FIS(Z) = fG : ISub(G) T Z = ;g. If P = FIS(Z) then Z is called a set of forbidden induced subgraphs (FIS) for P . A forbidden induced subgraph H 2 Z for P is minimal if ISub(H)nfHg ` P . A FIS­characterization of L l k is known when k = 2

331

ESAIM: Control, Optimisation and Calculus of Variations URL: http://www.emath.fr/cocv/  

E-Print Network [OSTI]

ESAIM: Control, Optimisation and Calculus of Variations URL: http://www.emath.fr/cocv/ December(fl(t))nf0g for almost every t: Let (; ) be the scalar product defined by g: The length of an admissible curve is: L(fl) = Z T 0 ( ?? fl(t); ?? fl(t)) 1 2 dt and the energy of fl is: E(fl) = Z T 0 ( ?? fl

Agrachev, Andrei

332

Design of a 465 MW Combined Cycle Cogeneration Plant  

E-Print Network [OSTI]

STEAM TUR8JNE GENERAIOR ELECTRICAl, POWER OUIPUI GAS TURBINE GENERAIORS ~==3:=:J PROCESS CONDENSATE TOIAl fUEl 90 MillION BBl./'l'R NEI ELECTRICAl GENERATION 46$.000 KW LOSSES Sl,\\OF JUHINPUI NfTHEAT . 10 PROCESS 43% EFFICIENT... energy efficiency within this operating envelope, the following design .features are incorporated: extraction-induction-condensing steam turbine modulating inlet guide vanes on the gas turbine~ supplementary firing on two boilers steam augmentation...

Leffler, D. W.

333

Comments on the U(1) axial symmetry and the chiral transition in QCD  

E-Print Network [OSTI]

We analyze (using a chiral effective Lagrangian model) the scalar and pseudoscalar meson mass spectrum of QCD at finite temperature, above the chiral transition at $T_c$, looking, in particular, for signatures of a possible breaking of the $U(1)$ axial symmetry above $T_c$. A detailed comparison between the case with a number of light quark flavors $N_f\\geq 3$ and the (remarkably different) case $N_f=2$ is performed.

Enrico Meggiolaro

2014-10-14T23:59:59.000Z

334

EIS-0350-S1: Supplemental Environmental Impact Statement for the Nuclear Facility Portion of the Chemistry and Metallurgy Research Building Replacement Project at Los Alamos National Laboratory, New Mexico  

Broader source: Energy.gov [DOE]

This Supplemental EIS evaluates the completion of the Chemistry and Metallurgy Research Building Replacement (CMRR) Project, which consists of constructing the nuclear facility portion (CMRR-NF) at Los Alamos National Laboratory (LANL). The CMRR Project provides the analytical chemistry and materials characterization capabilities currently or previously performed in the existing Chemistry and Metallurgy Research (CMR) Building. Because of recent detailed site geotechnical investigations, certain aspects of the CMRR-NR project have changed resulting in change to the environmental impacts.

335

Evaluation of six cycles of reciprocal recurrent selection in maize  

E-Print Network [OSTI]

. The progress obtained was measured by the yield nf selections x composites and frequency di. stributions of higher yieldin- elec- tions. Variability was estimated by the standard deviatson, co- efficient of variation, and range of the . elections... ? composites yield trials. Coefficients of inbreeding were also calculated for each composite at th. . beginning of every cycle, Results indicated t?. at reciprocal recurrent selection improved the frequency of higher yielding selections in the Ferguson...

Llorente, Carlos Fernando

1970-01-01T23:59:59.000Z

336

OSP WEEKLY FUNDING BULLETIN Volume 5, Issue 39 September 26, 2011  

E-Print Network [OSTI]

-04 CFDA No. 12.431 Due Date: Extends due date to 31 December 2011 http://www07.grants.gov) Solicitation No. W911NF-07-R-0001-05 CFDA No. 12.431 Due Date: Extends due date to 31 December 2011 http. ONRBAA11-031 CFDA No. 12.300 Due Date: White Papers: November 1, 2011 Full Proposals: January 10, 2012

Alabama in Huntsville, University of

337

Mercury Chamber Considerations  

E-Print Network [OSTI]

Mercury Chamber Considerations V. Graves IDS-NF Target Studies July 2011 #12;2 Managed by UT-Battelle for the U.S. Department of Energy Mercury Chamber Considerations, July 2011 Flow Loop Review · 1 cm dia nozzle, 20 m/s jet requires 1.57 liter/sec mercury flow (94.2 liter/min, 24.9 gpm). · MERIT experiment

McDonald, Kirk

338

Neutrino Factory Mercury Flow Loop  

E-Print Network [OSTI]

Neutrino Factory Mercury Flow Loop V. GravesV. Graves C. Caldwell IDS-NF Videoconference March 9, 2010 #12;Flow Loop Review · 1 cm dia nozzle, 20 m/s jet requires 1.57 liter/sec mercury flow (94 2 liter/min 24 9 gpm)mercury flow (94.2 liter/min, 24.9 gpm). · MERIT experiment showed that a pump

McDonald, Kirk

339

A New Formula for Prostate Cancer Lymph Node Risk  

SciTech Connect (OSTI)

Introduction: The successful treatment of prostate cancer depends on the accurate estimation of the risk of regional lymph node (LN) involvement. The Roach formula (RF) has been criticized as overestimating LN risk. A modification of the RF has been attempted by other investigators using simplified adjustment ratios: the Nguyen formula (NF). Methods and Materials: The National Cancer Institute Surveillance, Epidemiology, and End Results database was investigated for patients treated in 2004 through 2006 for whom at least 10 LN were examined at radical prostatectomy, cT1c or cT2 disease, and prostate-specific antigen (PSA) <26 ng/ml (N = 2,930). The Yale formula (YF) was derived from half of the sample (n = 1,460), and validated in the other half (n = 1,470). Results: We identified 2,930 patients. Only 4.6% of patients had LN+, and 72.6% had cT1c disease. Gleason (GS) 8-10 histology was found in 14.4% of patients. The YF for prediction of %LN+ risk is [GS - 5]x [PSA/3 + 1.5 x T], where T = 0, 1, and 2 for cT1c, cT2a, and cT2b/cT2c. Within each strata of predicted %LN+ risk, the actual %LN+ was closest to the YF. Using a >15% risk as an indicator of high-risk disease, the YF had increased sensitivity (39.0% vs. 13.6%) compared with the NF, without a significant reduction in specificity (94.9% vs. 98.8%). The NF was overly restrictive of the high-risk group, with only 2% of patients having a >15% risk of LN+ by that formula. Conclusion: The YF performed better than the RF and NF and was best at differentiating patients at high risk for LN+ disease.

Yu, James B., E-mail: james.b.yu@yale.ed [Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT (United States); Yale Cancer Center, New Haven, CT (United States); Makarov, Danil V. [Robert Wood Johnson Clinical Scholars Program, Yale School of Medicine, New Haven, CT (United States); Section of Urology, Yale School of Medicine, New Haven, CT (United States); Department of Veterans Affairs Connecticut Healthcare System, West Haven, CT (United States); Gross, Cary [Robert Wood Johnson Clinical Scholars Program, Yale School of Medicine, New Haven, CT (United States); Department of Internal Medicine, Yale School of Medicine, New Haven, CT (United States)

2011-05-01T23:59:59.000Z

340

A Multiple Integral Evaluation Inspired by the MultiWZ Akalu Tefera  

E-Print Network [OSTI]

A Multiple Integral Evaluation Inspired by the Multi­WZ Method 1 Akalu Tefera Department will appear in the author's Ph.D. thesis. 2 available from http \\Gamma k X j=1 D x j :R j annihilates F ,i.e., I X i=0 a i (n)F (n + i; m;y; x) \\Gamma k X j=1 D x j (R j

Tefera, Akalu

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

NIACC John Pappajohn Entrepreneurial Center JPEC | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF Energy Saving

342

NIEX Incubator | Open Energy Information  

Open Energy Info (EERE)

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343

NM Installation Requirements for UST Systems | Open Energy Information  

Open Energy Info (EERE)

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344

NMAC 1.2.2 Public Regulations Commission Rules of Procedure | Open Energy  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNM Stat.

345

NMAC 17.1.2 Utility Applications | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNM Stat.

346

NMAC 17.5.440 Extensions, Improvements, Additions, and Cooperative  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNM

347

NMAC 17.9.569 Interconnection of Generating Facilities with a Rated  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNMCapacity

348

NMAC 20.5 Petroleum Storage Tanks | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNMCapacity2

349

NMAC 20.6.2 Ground and Surface Water Protection | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNMCapacity2

350

NMAC 4.10.15 Cultural Properties and Historic Preservation Standards for  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF

351

NMAC 4.10.8 Permits to Conduct Archaeological Investigations on State Land  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF| Open Energy

352

NMAC Title 19 Natural Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF| Open EnergyNatural

353

NMDOT Application for Permit to Construct an Access or Median Opening on  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF| Open

354

NMDOT Application for Permit to Install Utility Facilities Within Public  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF| OpenROW | Open

355

NMED - Discharge Permit Application | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF| OpenROW |

356

NMED Petroleum Storage Tank Bureau webpage | Open Energy Information  

Open Energy Info (EERE)

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357

NMGWQB - Notice of Intent to Discharge | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF| OpenROW

358

NMHPD Application for Permit to Excavate Human Burials | Open Energy  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF|

359

NMOCD - Form G-101 - Application for Permit to Drill, Deepen, or Plug Back  

Open Energy Info (EERE)

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360

NMOCD - Form G-102 - Geothermal Resources Well Location and Acreage  

Open Energy Info (EERE)

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Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
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361

NMOCD - Form G-103 - Sundry Notices & Reports on Geothermal Resource Wells  

Open Energy Info (EERE)

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362

NMOCD - Form G-104 - Certificate of Compliance and Authorization to Produce  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF|Geothermal|

363

de r eche r che INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE  

E-Print Network [OSTI]

'' (R[ f\\Gamma1g; max; +), or the ``tropical semiring'' (N[f+1g;min;+), have been invented'alg??ebre lin??eaire (max,+) R??esum??e : Il s'agit d'une br??eve introduction au semi­anneau (max,+) et autres semiISSN 0249­6399 appo r t de r eche r che INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN

O'Sullivan, Joseph A.

364

Newsfront 10-16 March 2008, Issue 57  

E-Print Network [OSTI]

of Shivaratri. Two mistakes nf correspondent With just a month left for the polls to the constituent assembly, Prime Minister GP Koirala is giving conflicting messages regarding the party unity and the citizenship issue. According to senior leaders... Koirala and nephew Shekhar Koirala. PM Koiralas request was turned down by MJF leader Upendra Yadav and Bijay Gachchedar who are contest- ing election to the constituent assembly from Sunsari and Morang against Sujata and Shekhar respectively. PM Koirala...

Ghimire, Yubaraj

365

Requirement of T-lymphokine-activated killer cell-originated protein kinase for TRAIL resistance of human HeLa cervical cancer cells  

SciTech Connect (OSTI)

T-lymphokine-activated killer cell-originated protein kinase (TOPK) appears to be highly expressed in various cancer cells and to play an important role in maintaining proliferation of cancer cells. However, the underlying mechanism by which TOPK regulates growth of cancer cells remains elusive. Here we report that upregulated endogenous TOPK augments resistance of cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). Stable knocking down of TOPK markedly increased TRAIL-mediated apoptosis of human HeLa cervical cancer cells, as compared with control cells. Caspase 8 or caspase 3 activities in response to TRAIL were greatly incremented in TOPK-depleted cells. Ablation of TOPK negatively regulated TRAIL-mediated NF-{kappa}B activity. Furthermore, expression of NF-{kappa}B-dependent genes, FLICE-inhibitory protein (FLIP), inhibitor of apoptosis protein 1 (c-IAP1), or X-linked inhibitor of apoptosis protein (XIAP) was reduced in TOPK-depleted cells. Collectively, these findings demonstrated that TOPK contributed to TRAIL resistance of cancer cells via NF-{kappa}B activity, suggesting that TOPK might be a potential molecular target for successful cancer therapy using TRAIL.

Kwon, Hyeok-Ran [Department of Biochemistry, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon 302-718 (Korea, Republic of)] [Department of Biochemistry, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon 302-718 (Korea, Republic of); Lee, Ki Won [Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701 (Korea, Republic of)] [Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701 (Korea, Republic of); Dong, Zigang [Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912 (United States)] [Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912 (United States); Lee, Kyung Bok [Department of Biochemistry, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon 302-718 (Korea, Republic of)] [Department of Biochemistry, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon 302-718 (Korea, Republic of); Oh, Sang-Muk, E-mail: sangmuk_oh@konyang.ac.kr [Department of Biochemistry, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon 302-718 (Korea, Republic of)] [Department of Biochemistry, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon 302-718 (Korea, Republic of)

2010-01-01T23:59:59.000Z

366

Solvothermal synthesis of NiAl double hydroxide microspheres on a nickel foam-graphene as an electrode material for pseudo-capacitors  

SciTech Connect (OSTI)

In this paper, we demonstrate excellent pseudo-capacitance behavior of nickel-aluminum double hydroxide microspheres (NiAl DHM) synthesized by a facile solvothermal technique using tertbutanol as a structure-directing agent on nickel foam-graphene (NF-G) current collector as compared to use of nickel foam current collector alone. The structure and surface morphology were studied by X-ray diffraction analysis, Raman spectroscopy and scanning and transmission electron microscopies respectively. NF-G current collector was fabricated by chemical vapor deposition followed by an ex situ coating method of NiAl DHM active material which forms a composite electrode. The pseudocapacitive performance of the composite electrode was investigated by cyclic voltammetry, constant chargedischarge and electrochemical impedance spectroscopy measurements. The composite electrode with the NF-G current collector exhibits an enhanced electrochemical performance due to the presence of the conductive graphene layer on the nickel foam and gives a specific capacitance of 1252 F g{sup ?1} at a current density of 1 A g{sup ?1} and a capacitive retention of about 97% after 1000 chargedischarge cycles. This shows that these composites are promising electrode materials for energy storage devices.

Momodu, Damilola; Bello, Abdulhakeem; Dangbegnon, Julien; Barzeger, Farshad; Taghizadeh, Fatimeh; Fabiane, Mopeli; Manyala, Ncholu, E-mail: ncholu.manyala@up.ac.za [Department of Physics, Institute of Applied Materials, SARChI Chair in Carbon Technology and Materials, University of Pretoria, Pretoria 0028, South Africa. (South Africa); Johnson, A. T. Charlie [Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)

2014-09-15T23:59:59.000Z

367

Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice  

SciTech Connect (OSTI)

Excessive alcohol consumption can lead to gastric ulcer and the present work was aimed to examine the protective effect of tetrahydrocoptisine (THC) in the model of ethanol-induced gastric ulcer in mice. Fasted mice treated with ethanol 75% (0.5 ml/100 g) were pre-treated with THC (10 or 20 mg/kg, ip), cimetidine (100 mg/kg, ip) or saline in different experimental sets for a period of 3 days, and animals were euthanized 4 h after ethanol ingestion. Gross and microscopic lesions, immunological and biochemical parameters were taken into consideration. The results showed that ethanol induced gastric damage, improving nitric oxide (NO) level, increased pro-inflammatory cytokine (TNF-? and IL-6) levels and myeloperoxidase (MPO) activity, as well as the expression of nuclear factor-?B (NF-?B) in the ethanol group. Pretreatment of THC at doses of 10 and 20 mg/kg bodyweight significantly attenuated the gastric lesions as compared to the ethanol group. These results suggest that the gastroprotective activity of THC is attributed to reducing NO production and adjusting the pro-inflammatory cytokine, inhibited neutrophil accumulation and NF-?B expression. - Highlights: THC decreased ethanol-induced pro-inflammatory cytokine release. THC inhibited the production of NO in serum and gastric tissue. THC reduced NF-?B expression and MPO accumulation in ethanol-induced gastric tissue.

Li, Weifeng, E-mail: liwf@mail.xjtu.edu.cn; Huang, Huimin; Niu, Xiaofeng, E-mail: niuxf@mail.xjtu.edu.cn; Fan, Ting; Mu, Qingli; Li, Huani

2013-10-01T23:59:59.000Z

368

Anti-inflammatory effect of resveratrol on TNF-{alpha}-induced MCP-1 expression in adipocytes  

SciTech Connect (OSTI)

Chronic low-grade inflammation characterized by adipose tissue macrophage accumulation and abnormal cytokine production is a key feature of obesity and type 2 diabetes. Adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, induced by cytokines, has been shown to play an essential role in the early events during macrophage infiltration into adipose tissue. In this study we investigated the effects of resveratrol upon both tumor necrosis factor (TNF)-{alpha}-induced MCP-1 gene expression and its underlying signaling pathways in 3T3-L1 adipoctyes. Resveratrol was found to inhibit TNF-{alpha}-induced MCP-1 secretion and gene transcription, as well as promoter activity, which based on down-regulation of TNF-{alpha}-induced MCP-1 transcription. Nuclear factor (NF)-{kappa}B was determined to play a major role in the TNF-{alpha}-induced MCP-1 expression. Further analysis showed that resveratrol inhibited DNA binding activity of the NF-{kappa}B complex and subsequently suppressed NF-{kappa}B transcriptional activity in TNF-{alpha}-stimulated cells. Finally, the inhibition of MCP-1 may represent a novel mechanism of resveratrol in preventing obesity-related pathologies.

Zhu Jian [Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Key Laboratory of Human Functional Genomics of Jiangsu Province, School of Basic Medical Science, Jiangsu Province Diabetes Center, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029 (China); Yong Wei [Key Laboratory of Human Functional Genomics of Jiangsu Province, School of Basic Medical Science, Jiangsu Province Diabetes Center, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029 (China); Wu Xiaohong [Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Yu Ying; Lv Jinghuan [Key Laboratory of Human Functional Genomics of Jiangsu Province, School of Basic Medical Science, Jiangsu Province Diabetes Center, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029 (China); Liu Cuiping; Mao Xiaodong [Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Zhu Yunxia [Key Laboratory of Human Functional Genomics of Jiangsu Province, School of Basic Medical Science, Jiangsu Province Diabetes Center, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029 (China); Xu Kuanfeng [Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Han Xiao [Key Laboratory of Human Functional Genomics of Jiangsu Province, School of Basic Medical Science, Jiangsu Province Diabetes Center, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029 (China)], E-mail: hanxiao@njmu.edu.cn; Liu Chao [Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China)], E-mail: liuchao@nfmcn.com

2008-05-02T23:59:59.000Z

369

Achieving very low mercury levels in refinery wastewater by membrane filtration.  

SciTech Connect (OSTI)

Microfiltration (MF), ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO) membranes were evaluated for their ability to achieve the world's most stringent Hg discharge criterion (<1.3 ng/L) in an oil refinery's wastewater. The membrane processes were operated at three different pressures to demonstrate the potential for each membrane technology to achieve the targeted effluent mercury concentrations. The presence of mercury in the particulate form in the refinery wastewater makes the use of MF and UF membrane technologies more attractive in achieving very low mercury levels in the treated wastewater. Both NF and RO were also able to meet the target mercury concentration at lower operating pressures (20.7 bar). However, higher operating pressures ({ge}34.5 bar) had a significant effect on NF and RO flux and fouling rates, as well as on permeate quality. SEM images of the membranes showed that pore blockage and narrowing were the dominant fouling mechanisms for the MF membrane while surface coverage was the dominant fouling mechanism for the other membranes. The correlation between mercury concentration and particle size distribution was also investigated to understand mercury removal mechanisms by membrane filtration. The mean particle diameter decreased with filtration from 1.1 {+-} 0.0 {micro}m to 0.74 {+-} 0.2 {micro}m after UF.

Urgun Demirtas, M.; Benda, P.; Gillenwater, P. S.; Negri, M. C.; Xiong, H.; Snyder, S. W. (Center for Nanoscale Materials); ( ES)

2012-05-15T23:59:59.000Z

370

Functional Toll-like receptor 4 expressed in lactotrophs mediates LPS-induced proliferation in experimental pituitary hyperplasia  

SciTech Connect (OSTI)

Toll like receptor 4 (TLR4) has been characterized for its ability to recognize bacterial endotoxin lipopolysaccharide (LPS). Considering that infections or inflammatory processes might contribute to the progression of pituitary tumors, we analyzed the TLR4 functional role by evaluating the LPS effect on lactotroph proliferation in primary cultures from experimental pituitary tumors, and examined the involvement of PI3K-Akt and NF-?B activation in this effect. In addition, the role of 17?-estradiol as a possible modulator of LPS-induced PRL cell proliferation was further investigated. In estrogen-induced hyperplasic pituitaries, LPS triggered lactotroph cell proliferation. However, endotoxin failed to increase the number of lactotrophs taking up BrdU in normal pituitaries. Moreover, incubation with anti-TLR4 antibody significantly reduced LPS-induced lactotroph proliferation, suggesting a functional role of this receptor. As a sign of TLR4 activation, an LPS challenge increased IL-6 release in normal and tumoral cells. By flow cytometry, TLR4 baseline expression was revealed at the plasma membrane of tumoral lactotrophs, without changes noted in the percentage of double PRL/TLR4 positive cells after LPS stimulus. Increases in TLR4 intracellular expression were detected as well as rises in CD14, p-Akt and NF-?B after an LPS challenge, as assessed by western blotting. The TLR4/PRL and PRL/NF-?B co-localization was also corroborated by immunofluorescence and the involvement of PI3K/Akt signaling in lactotroph proliferation and IL-6 release was revealed through the PI3K inhibitor Ly-294002. In addition, 17?-estradiol attenuated the LPS-evoked increase in tumoral lactotroph proliferation and IL-6 release. Collectively these results demonstrate the presence of functional TLR4 in lactotrophs from estrogen-induced hyperplasic pituitaries, which responded to the proliferative stimulation and IL-6 release induced by LPS through TLR4/CD14, with a contribution of the PI3K-Akt and NF-?B signaling pathways. - Highlights: In hyperplastic pituitaries, LPS triggered the lactotroph cell proliferation and IL-6 release. Functional Toll-like receptor 4 (TLR4) is expressed at the plasma membrane of tumoral lactotrophs. Increases in TLR4 and CD14 intracellular expression levels were detected after an LPS challenge. The proliferative stimulation and IL-6 release involved the PI3K-Akt pathway and NF-?B activation. 17?-estradiol attenuated the LPS-evoked tumoral lactotroph proliferation and IL-6 secretion.

Sabatino, Mara Eugenia; Sosa, Liliana del Valle; Petiti, Juan Pablo; Mukdsi, Jorge Humberto [Centro de Microscopa Electrnica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Mdicas, Universidad Nacional de Crdoba, Av. Enrique Barros y Enfermera Gordillo, Ciudad Universitaria, CP 5000, Crdoba (Argentina); Mascanfroni, Ivn Daro; Pellizas, Claudia Gabriela [Centro de Investigaciones en Bioqumica Clnica e Inmunologa (CIBICI-CONICET), Facultad de Ciencias Qumicas, Universidad Nacional de Crdoba, Av. Haya de la Torre y Medina Allende, Ciudad Universitaria, CP 5000, Crdoba (Argentina); Gutirrez, Silvina; Torres, Alicia Ins [Centro de Microscopa Electrnica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Mdicas, Universidad Nacional de Crdoba, Av. Enrique Barros y Enfermera Gordillo, Ciudad Universitaria, CP 5000, Crdoba (Argentina); De Paul, Ana Luca, E-mail: adepaul@cmefcm.uncor.edu [Centro de Microscopa Electrnica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Mdicas, Universidad Nacional de Crdoba, Av. Enrique Barros y Enfermera Gordillo, Ciudad Universitaria, CP 5000, Crdoba (Argentina)

2013-11-15T23:59:59.000Z

371

NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-?-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells  

SciTech Connect (OSTI)

TNF-? plays a mediator role in the pathogenesis of chronic heart failure contributing to cardiac remodeling and peripheral vascular disturbances. The implication of TNF-? in inflammatory responses has been shown to be mediated through up-regulation of matrix metalloproteinase-9 (MMP-9). However, the detailed mechanisms of TNF-?-induced MMP-9 expression in rat embryonic-heart derived H9c2 cells are largely not defined. We demonstrated that in H9c2 cells, TNF-? induced MMP-9 mRNA and protein expression associated with an increase in the secretion of pro-MMP-9. TNF-?-mediated responses were attenuated by pretreatment with the inhibitor of ROS (N-acetyl-L-cysteine, NAC), NADPH oxidase [apocynin (APO) or diphenyleneiodonium chloride (DPI)], MEK1/2 (U0126), p38 MAPK (SB202190), JNK1/2 (SP600125), NF-?B (Bay11-7082), or PYK2 (PF-431396) and transfection with siRNA of TNFR1, p47{sup phox}, p42, p38, JNK1, p65, or PYK2. Moreover, TNF-? markedly induced NADPH oxidase-derived ROS generation in these cells. TNF-?-enhanced p42/p44 MAPK, p38 MAPK, JNK1/2, and NF-?B (p65) phosphorylation and in vivo binding of p65 to the MMP-9 promoter were inhibited by U0126, SB202190, SP600125, NAC, DPI, or APO. In addition, TNF-?-mediated PYK2 phosphorylation was inhibited by NAC, DPI, or APO. PYK2 inhibition could reduce TNF-?-stimulated MAPKs and NF-?B activation. Thus, in H9c2 cells, we are the first to show that TNF-?-induced MMP-9 expression is mediated through a TNFR1/NADPH oxidase/ROS/PYK2/MAPKs/NF-?B cascade. We demonstrated that NADPH oxidase-derived ROS generation is involved in TNF-?-induced PYK2 activation in these cells. Understanding the regulation of MMP-9 expression and NADPH oxidase activation by TNF-? on H9c2 cells may provide potential therapeutic targets of chronic heart failure. - Highlights: TNF-? induces MMP-9 secretion and expression via a TNFR1-dependent pathway. TNF-? induces ROS/PYK2-dependent MMP-9 expression in H9c2 cells. TNF-? induces MMP-9 expression via a NADPH oxidase/ROS-dependent NF-?B signaling. TNF-? activates MAPK phosphorylation through NADPH oxidase/ROS generation.

Yang, Chuen-Mao, E-mail: chuenmao@mail.cgu.edu.tw [Department of Physiology and Pharmacology and Health Aging Research Center, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan (China); Lee, I-Ta [Department of Physiology and Pharmacology and Health Aging Research Center, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Department of Anesthetics, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Hsu, Ru-Chun; Chi, Pei-Ling; Hsiao, Li-Der [Department of Physiology and Pharmacology and Health Aging Research Center, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China)

2013-10-15T23:59:59.000Z

372

Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1  

SciTech Connect (OSTI)

Cytochrome P450 (CYP) 2E1 was suggested to be the major enzyme involved in trichloroethylene (TRI) metabolism and TRI-induced hepatotoxicity, although the latter molecular mechanism is not fully understood. The involvement of CYP2E1 in TRI-induced hepatotoxicity and its underlying molecular mechanism were studied by comparing hepatotoxicity in cyp2e1{sup +/+} and cyp2e1{sup -/-} mice. The mice were exposed by inhalation to 0 (control), 1000, or 2000 ppm of TRI for 8 h a day, for 7 days, and TRI-hepatotoxicity was assessed by measuring plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and histopathology. Urinary metabolites of trichloroethanol and trichloroacetic acid (TCA) were considerably greater in cyp2e1{sup +/+} compared to cyp2e1{sup -/-} mice, suggesting that CYP2E1 is the major P450 involved in the formation of these metabolites. Consistent with elevated plasma ALT and AST activities, cyp2e1{sup +/+} mice in the 2000 ppm group showed histopathological inflammation. TRI significantly upregulated PPAR{alpha}, which might function to inhibit NF{kappa}B p50 and p65 signalling. In addition, TRI-induced NF{kappa}B p52 mRNA, and significantly positive correlation between NF{kappa}B p52 mRNA expression and plasma ALT activity levels were observed, suggesting the involvement of p52 in liver inflammation. Taken together, the current study directly demonstrates that CYP2E1 was the major P450 involved in the first step of the TRI metabolism, and the metabolites produced may have two opposing roles: one inducing hepatotoxicity and the other protecting against the toxicity. Intermediate metabolite(s) from TRI to chloral hydrate produced by CYP2E1-mediated oxidation may be involved in the former, and TCA in the latter.

Ramdhan, Doni Hikmat; Kamijima, Michihiro; Yamada, Naoyasu; Ito, Yuki; Yanagiba, Yukie; Nakamura, Daichi; Okamura, Ai; Ichihara, Gaku [Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine (Japan); Aoyama, Toshifumi [Department of Metabolic Regulation, Institute of Aging and Adaptation, Shinshu University Graduate School of Medicine (Japan); Gonzalez, Frank J. [Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States); Nakajima, Tamie [Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine (Japan)], E-mail: tnasu23@med.nagoya-u.ac.jp

2008-09-15T23:59:59.000Z

373

Insights antifibrotic mechanism of methyl palmitate: Impact on nuclear factor kappa B and proinflammatory cytokines  

SciTech Connect (OSTI)

Fibrosis accompanies most chronic liver disorders and is a major factor contributing to hepatic failure. Therefore, the need for an effective treatment is evident. The present study was designed to assess the potential antifibrotic effect of MP and whether MP can attenuate the severity of oxidative stress and inflammatory response in chronic liver injury. Male albino rats were treated with either CCl{sub 4} (1 ml/kg, twice a week) and/or MP (300 mg/kg, three times a week) for six weeks. CCl{sub 4}-intoxication significantly increased liver weight, serum aminotransferases, total cholesterol and triglycerides while decreased albumin level and these effects were prevented by co-treatment with MP. As indicators of oxidative stress, CCl{sub 4}-intoxication caused significant glutathione depletion and lipid peroxidation while MP co-treatment preserved them within normal values. As markers of fibrosis, hydroxyproline content and ?-SMA expression increased markedly in the CCl{sub 4} group and MP prevented these alterations. Histopathological examination by both light and electron microscope further confirmed the protective efficacy of MP. To elucidate the antifibrotic mechanisms of MP, the expression of NF-?B, iNOS and COX-2 and the tissue levels of TNF-? and nitric oxide were assessed; CCl{sub 4} increased the expression of NF-?B and all downstream inflammatory cascade while MP co-treatment inhibited them. Collectively these findings indicate that MP possesses a potent antifibrotic effect which may be partly a consequence of its antioxidant and anti-inflammatory properties. -- Highlights: ? Methyl palmitate is free fatty acid methyl ester. ? It possesses a strong antifibrotic effect. ? It inhibits NF-?B and the consequent proinflammatory and oxidative stress response.

Mantawy, Eman M.; Tadros, Mariane G. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); Awad, Azza S. [Department of Pharmacology and Toxicology, Faulty of Pharmacy, Al-Azhar University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faulty of Pharmacy, Al-Azhar University, Cairo (Egypt); Hassan, Dina A.A. [Department of Histology, Faculty of Medicine, Al-Azhar University, Cairo (Egypt)] [Department of Histology, Faculty of Medicine, Al-Azhar University, Cairo (Egypt); El-Demerdash, Ebtehal, E-mail: ebtehal_dm@yahoo.com [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)

2012-01-01T23:59:59.000Z

374

Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1{beta} secretion  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer EGCG inhibits melanoma cell growth at physiological doses (0.1-1 {mu}M). Black-Right-Pointing-Pointer EGCG inhibits melanoma cell growth via inflammasomes and IL-1{beta} suppression. Black-Right-Pointing-Pointer Inflammasomes and IL-1{beta} could be potential targets for future melanoma therapeutics. -- Abstract: Epigallocatechin-3-gallate (EGCG), the major polyphenolic component of green tea, has been demonstrated to possess anti-inflammatory, antioxidant, anti-mutagenic and anti-carcinogenic properties. The anti-melanoma effect of EGCG has been previously suggested, but no clear mechanism of action has been established. In this study, we demonstrated that EGCG inhibits melanoma cell growth at physiological doses (0.1-1 {mu}M). In the search for mechanisms of EGCG-mediated melanoma cell suppression, we found that NF-{kappa}B was inhibited, and that reduced NF-{kappa}B activity was associated with decreased IL-1{beta} secretion from melanoma cells. Since inflammasomes are involved in IL-1{beta} secretion, we investigated whether IL-1{beta} suppression was mediated by inflammasomes, and found that EGCG treatment led to downregulation of the inflammasome component, NLRP1, and reduced caspase-1 activation. Furthermore, silencing the expression of NLRP1 abolished EGCG-induced inhibition of tumor cell proliferation both in vitro and in vivo, suggesting a key role of inflammasomes in EGCG efficacy. This paper provides a novel mechanism for EGCG-induced melanoma inhibition: inflammasome downregulation {yields} decreased IL-1{beta} secretion {yields} decreased NF-{kappa}B activities {yields} decreased cell growth. In addition, it suggests inflammasomes and IL-1{beta} could be potential targets for future melanoma therapeutics.

Ellis, Lixia Z.; Liu, Weimin; Luo, Yuchun; Okamoto, Miyako; Qu, Dovina; Dunn, Jeffrey H. [Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045 (United States)] [Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Fujita, Mayumi, E-mail: mayumi.fujita@ucdenver.edu [Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045 (United States) [Department of Dermatology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Denver Veterans Affairs Medical Center, Denver, CO 80220 (United States)

2011-10-28T23:59:59.000Z

375

Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells  

SciTech Connect (OSTI)

Carbon nanotubes (CNT) are cytotoxic to several cell types. However, the mechanism of CNT toxicity has not been fully studied, and dosimetric analyses of CNT in the cell culture system are lacking. Here, we describe a novel, high throughput method to measure cellular uptake of CNT using turbimetry. BEAS-2B, a human bronchial epithelial cell line, was used to investigate cellular uptake, cytotoxicity, and inflammatory effects of multi-walled CNT (MWCNT). The cytotoxicity of MWCNT was higher than that of crocidolite asbestos in BEAS-2B cells. The IC{sub 50} of MWCNT was 12 {mu}g/ml, whereas that of asbestos (crocidolite) was 678 {mu}g/ml. Over the course of 5 to 8 h, BEAS-2B cells took up 17-18% of the MWCNT when they were added to the culture medium at a concentration of 10 {mu}g/ml. BEAS-2B cells were exposed to 2, 5, or 10 {mu}g/ml of MWCNT, and total RNA was extracted for cytokine cDNA primer array assays. The culture supernatant was collected for cytokine antibody array assays. Cytokines IL-6 and IL-8 increased in a dose dependent manner at both the mRNA and protein levels. Migration inhibitory factor (MIF) also increased in the culture supernatant in response to MWCNT. A phosphokinase array study using lysates from BEAS-2B cells exposed to MWCNT indicated that phosphorylation of p38, ERK1, and HSP27 increased significantly in response to MWCNT. Results from a reporter gene assays using the NF-{kappa}B or AP-1 promoter linked to the luciferase gene in transiently transfected CHO-KI cells revealed that NF-{kappa}B was activated following MWCNT exposure, while AP-1 was not changed. Collectively, MWCNT activated NF-{kappa}B, enhanced phosphorylation of MAP kinase pathway components, and increased production of proinflammatory cytokines in human bronchial epithelial cells.

Hirano, Seishiro, E-mail: seishiro@nies.go.j [Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies (Japan); Fujitani, Yuji; Furuyama, Akiko [Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies (Japan); Kanno, Sanae [Photon Medical Research Center, Hamamatsu University School of Medicine (Japan)

2010-11-15T23:59:59.000Z

376

Role of endoplasmic reticulum stress in acrolein-induced endothelial activation  

SciTech Connect (OSTI)

Acrolein is a ubiquitous environmental pollutant and an endogenous product of lipid peroxidation. It is also generated during the metabolism of several drugs and amino acids. In this study, we examined the effects of acrolein on endothelial cells. Treatment of human umbilical vein endothelial cells (HUVECs) with 2 to 10 {mu}M acrolein led to an increase in the phosphorylation of eIF-2{alpha} within 10 to 30 min of exposure. This was followed by alternate splicing of XBP-1 mRNA and an increase in the expression of the endoplasmic reticulum (ER) chaperone genes Grp78 and Herp. Within 2-4 h of treatment, acrolein also increased the abundance and the nuclear transport of the transcription factors ATF3, AFT4, and CHOP. Acrolein-induced increase in ATF3 was prevented by treating the cells with the chemical chaperone - phenylbutyric acid (PBA). Treatment with acrolein increased phosphorylation of ERK1/2, p38, and JNK. The increase in JNK phosphorylation was prevented by PBA. Acrolein treatment led to activation and nuclear translocation of the transcription factor NF-{kappa}B and an increase in TNF-{alpha}, IL-6 and IL-8, but not MCP-1, mRNA. Increased expression of cytokine genes and NF-{kappa}B activation were not observed in cells treated with PBA. These findings suggest that exposure to acrolein induces ER stress and triggers the unfolded protein response and that NF-{kappa}B activation and stimulation of cytokine production by acrolein could be attributed, in part, to ER stress. Chemical chaperones of protein-folding may be useful in treating toxicological and pathological states associated with excessive acrolein exposure or production.

Haberzettl, Petra; Vladykovskaya, Elena; Srivastava, Sanjay [Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202 (United States); Bhatnagar, Aruni [Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202 (United States)], E-mail: aruni@louisville.edu

2009-01-01T23:59:59.000Z

377

Resistivity of low percentage perylene to iodine complexes and their excess noise spectra  

E-Print Network [OSTI]

that pressed prlycrystalline samples and single crystals should yield the same activation energy. & However others have ~btained activation energies nf 1 to 1 . 5 ev i'nr single crystal s. 9 & 3 L511er reports a rapid droop in activation energy from 0. 7... 0. 60 0. 34 0. 13 0. 35 0. 24 Extrinsic 0, 034 0. 034 0. 056 0, 059 (oZ) 240 250 288 Int. 10 3 10 4 0. 2 50 0. 2 106 10 104 10 Table 1. Information Cbtained from Figures e through P, 16 decreasing the gap between them...

Caruthers, Jerald Wayne

1966-01-01T23:59:59.000Z

378

Thermodynamics using p4-improved staggered fermion action on QCDOC  

E-Print Network [OSTI]

We present an exploratory study of the thermodynamics of $N_f=3$ QCD with an improved staggered fermions using the QCDOC supercomputer. We use a p4 action with MILC-style smeared links (Fat 7). Some details of the implementation of the p4 action on QCDOC are discussed and performance benchmarks are given. We show preliminary results for the quark mass dependence of the pseudo-critical temperature $T_c$ from several lattice volumes . We also make a comparison between p4fat7 and the old p4 action.

Chulwoo Jung

2005-10-05T23:59:59.000Z

379

Development and Use of Baseline Monthly Utility Models for Eight Army Installations Around the United States  

E-Print Network [OSTI]

3/96-Final Report, p. i ESL-TR-96/03-01 DEVELOPMENT AND USE OF BASELINE MONTHLY UTILITY MODELS FOR EIGHT ARMY INSTALLATIONS AROUND THE UNITED STATES Prepared by: T.A. Reddy, N.F. Saman, D.E. Claridge, J.S. Haberl and W.D. Turner Research Sponsored... and Scope 2 2.1 Objectives 2 2.2 Data provided 3 2.3 Scope of study 7 3.0 Mathematical Basis of Regression Models 8 3.1 Pertinent background 8 3.2 Simple regression models using Emodel 9 3.3 Generation of 95% uncertainty bands for individual months 14 3...

Reddy, T. A.; Saman, N. F.; Claridge, D. E.; Haberl, J. S.; Turner, W. D.

1996-01-01T23:59:59.000Z

380

Leptonic B- and D-meson decay constants with 2+1 flavors of asqtad fermions  

E-Print Network [OSTI]

We present the status of our updated D- and B-meson decay-constant analysis, based on the MILC $N_f = 2+1$ asqtad gauge ensembles. Heavy quarks are incorporated using the Wilson clover action with the Fermilab interpretation. This analysis includes ensembles at five lattice spacings from a $\\approx$ 0.045 to 0.15 fm, and light sea-quark masses down to 1/20th of the strange-quark mass. Projected error budgets for ratios of decay constants, in particular between bottom- and charm-meson decay constants, are presented.

Kronfeld, Andreas S; Simone, James N; Van de Water, Ruth S

2015-01-01T23:59:59.000Z

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381

Leptonic B- and D-meson decay constants with 2+1 flavors of asqtad fermions  

E-Print Network [OSTI]

We present the status of our updated D- and B-meson decay-constant analysis, based on the MILC $N_f = 2+1$ asqtad gauge ensembles. Heavy quarks are incorporated using the Wilson clover action with the Fermilab interpretation. This analysis includes ensembles at five lattice spacings from a $\\approx$ 0.045 to 0.15 fm, and light sea-quark masses down to 1/20th of the strange-quark mass. Projected error budgets for ratios of decay constants, in particular between bottom- and charm-meson decay constants, are presented.

Andreas S. Kronfeld; Ethan T. Neil; James N. Simone; Ruth S. Van de Water; for the Fermilab Lattice Collaboration; for the MILC Collaboration

2015-01-08T23:59:59.000Z

382

Delayed neutron yield from fast neutron induced fission of sup 2 sup 3 sup 8 U  

E-Print Network [OSTI]

The measurements of the total delayed neutron yield from fast neutron induced fission of sup 2 sup 3 sup 8 U were made. The experimental method based on the periodic irradiation of the fissionable sample by neutrons from a suitable nuclear reaction had been employed. The preliminary results on the energy dependence of the total delayed neutron yield from fission of sup 2 sup 3 sup 8 U are obtained. According to the comparison of experimental data with our prediction based on correlation properties of delayed neutron characteristics, it is concluded that the value of the total delayed neutron yield near the threshold of (n,f) reaction is not a constant.

Piksaikin, V M; Isaev, S G; Kazakov, L E; Roshchenko, V A; Tertytchnyi, R G

2001-01-01T23:59:59.000Z

383

Effects of electrical stimulation high temperature pre-rigor conditioning on myofibrillar proteins of bovine muscle  

E-Print Network [OSTI]

as an untreated control to compare with the treated side. The rate nf pH decline was monitored for 48 hr postmortem. d. pl*a df th ~t'" ' d 4 . 1 1 ddhp ddt th~4''1*lddf p Nyofibrils were purified from each of the muscle samples. The nyo- fibrillar proteins... to troponin solut ions during incubation, the loss of troponio activity is reduced. Proteolytic Systems in Huscle There are at least three theories regarding changes in myofibril- lar proteins and concomitant changes in tenderness. The first, typi- fied...

Adams, Keith LeRoy

2012-06-07T23:59:59.000Z

384

Involvement of nuclear factor {kappa}B in platelet CD40 signaling  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer sCD40L induces TRAF2 association to CD40 and NF-{kappa}B activation in platelets. Black-Right-Pointing-Pointer I{kappa}B{alpha} phosphorylation downstream of CD40L/CD40 signaling is independent of p38 MAPK phosphorylation. Black-Right-Pointing-Pointer I{kappa}B{alpha} is required for sCD40L-induced platelet activation and potentiation of aggregation. -- Abstract: CD40 ligand (CD40L) is a thrombo-inflammatory molecule that predicts cardiovascular events. Platelets constitute the major source of soluble CD40L (sCD40L), which has been shown to potentiate platelet activation and aggregation, in a CD40-dependent manner, via p38 mitogen activated protein kinase (MAPK) and Rac1 signaling. In many cells, the CD40L/CD40 dyad also induces activation of nuclear factor kappa B (NF-{kappa}B). Given that platelets contain NF-{kappa}B, we hypothesized that it may be involved in platelet CD40 signaling and function. In human platelets, sCD40L induces association of CD40 with its adaptor protein the tumor necrosis factor receptor associated factor 2 and triggers phosphorylation of I{kappa}B{alpha}, which are abolished by CD40L blockade. Inhibition of I{kappa}B{alpha} phosphorylation reverses sCD40L-induced I{kappa}B{alpha} phosphorylation without affecting p38 MAPK phosphorylation. On the other hand, inhibition of p38 MAPK phosphorylation has no effect on I{kappa}B{alpha} phosphorylation, indicating a divergence in the signaling pathway originating from CD40 upon its ligation. In functional studies, inhibition of I{kappa}B{alpha} phosphorylation reverses sCD40L-induced platelet activation and potentiation of platelet aggregation in response to a sub-threshold concentration of collagen. This study demonstrates that the sCD40L/CD40 axis triggers NF-{kappa}B activation in platelets. This signaling pathway plays a critical role in platelet activation and aggregation upon sCD40L stimulation and may represent an important target against thrombo-inflammatory disorders.

Hachem, Ahmed [Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8 (Canada)] [Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8 (Canada); Yacoub, Daniel [Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8 (Canada) [Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8 (Canada); Centre Hospitalier Universite de Montreal, 264 boul. Rene-Levesque est, Montreal, Quebec, Canada H2X 1P1 (Canada); Zaid, Younes [Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8 (Canada)] [Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8 (Canada); Mourad, Walid [Universite de Montreal, Department of Medicine, 2900 boul. Edouard-Montpetit, Montreal, Quebec, Canada H3T 1J4 (Canada) [Universite de Montreal, Department of Medicine, 2900 boul. Edouard-Montpetit, Montreal, Quebec, Canada H3T 1J4 (Canada); Centre Hospitalier Universite de Montreal, 264 boul. Rene-Levesque est, Montreal, Quebec, Canada H2X 1P1 (Canada); Merhi, Yahye, E-mail: yahye.merhi@icm-mhi.org [Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8 (Canada) [Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8 (Canada); Universite de Montreal, Department of Medicine, 2900 boul. Edouard-Montpetit, Montreal, Quebec, Canada H3T 1J4 (Canada)

2012-08-17T23:59:59.000Z

385

Two-dimensional, subsonic, flowfield analysis for arbitrary boundaries with lifting bodies  

E-Print Network [OSTI]

and negative circula- tion strengths, respect1vely INTRODUCTION The use of a wind tunnel to measure the aerodynam1c properties of a two-d1mens 1onal airfoil yields results which differ from those ob- ta1ned 1n free air. For inviscid flow these d1fferences... in that the freestream or the "1nf1nity" condit1ons must be determ1ned in close proxim1ty to the airfoil (Figure I). Since it 1s desirable to test at Reynolds numbers approximat1ng f11ght conditions, the trend has been to increase the model size. For a f1xed wind...

Noack, Ralph Wayne

1981-01-01T23:59:59.000Z

386

QCD chiral symmetry restoration with a large number of quarks in a model with a confining propagator and dynamically massive gluons  

E-Print Network [OSTI]

Considering a QCD chiral symmetry breaking model where the gap equation contains an effective confining propagator and a dressed gluon propagator with a dynamically generated mass, we verify that the chiral symmetry is restored for a large number of quarks $n_{f}\\approx 11-13$. We discuss the uncertainty in the results, that is related to the determination of the string tension ($K_{F}$), appearing in the confining propagator, and the effective gluon mass ($m_{g}$) at large $n_{f}$.

R. M. Capdevilla; A. Doff; A. A. Natale

2014-09-25T23:59:59.000Z

387

The relationship between soil water utilization and the phosphorus status of sorghum  

E-Print Network [OSTI]

THE RELATIONSHIP BETWEEN SOIL WATER UTILIZATION AND THE PHOSPHORUS S'rATUS OF SORGHUM A Thesis ABDOUL ABDOULAYE SOW Submitted to the Office of Gi adua. e Stuches of Texas A8-M University in partial fulfillment nf the requirements... for the desmee of MASTER OF SCIENCE May 1990 Major Subject: Soil Science THE RELATIONSHIP BETWEEN SOIL WATER UTILIZATION AND THE PHOSPHORUS STATUS OF SORGHUM A Thesis ABDOUL ABDOULAYE SOW Approved as to style and content, by: I loyd R. Hossner (Chair of...

Sow, Abdoul Abdoulaye

1990-01-01T23:59:59.000Z

388

Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain, optic nerve and retina  

SciTech Connect (OSTI)

Arsenic (As), lead (Pb) and cadmium (Cd) are the major metal contaminants of ground water in India. We have reported the toxic effect of their mixture (metal mixture, MM), at human relevant doses, on developing rat astrocytes. Astrocyte damage has been shown to be associated with myelin disintegration in CNS. We, therefore, hypothesized that the MM would perturb myelinating white matter in cerebral cortex, optic nerve (O.N.) and retina. We observed modulation in the levels of myelin and axon proteins, such as myelin basic protein (MBP), proteolipid protein, 2?-, 3?-cyclic-nucleotide-3?-phosphodiesterase, myelin-associated glycoprotein and neurofilament (NF) in the brain of developing rats. Dose and time-dependent synergistic toxic effect was noted. The MBP- and NF-immunolabeling, as well as luxol-fast blue (LFB) staining demonstrated a reduction in the area of intact myelin-fiber, and an increase in vacuolated axons, especially in the corpus-callosum. Transmission electron microscopy (TEM) of O.N. revealed a reduction in myelin thickness and axon-density. The immunolabeling with MBP, NF, and LFB staining in O.N. supported the TEM data. The hematoxylin and eosin staining of retina displayed a decrease in the thickness of nerve-fiber, plexiform-layer, and retinal ganglion cell (RGC) count. Investigating the mechanism revealed a loss in glutamine synthetase activity in the cerebral cortex and O.N., and a fall in the brain derived neurotrophic factor in retina. An enhanced apoptosis in MBP, NF and Brn3b-containing cells justified the diminution in myelinating axons in CNS. Our findings for the first time indicate white matter damage by MM, which may have significance in neurodevelopmental-pediatrics, neurotoxicology and retinal-cell biology. - Highlights: As, Cd and Pb-mixture, at human relevant dose, demyelinate developing rat CNS. The attenuation in myelin and axon is synergistic. The optic nerve and brain demonstrate reduced glutamine synthetase. The retina exhibits diminished neurotrophin levels and cellular differentiation. The toxic effect is apoptotic.

Rai, Nagendra Kumar; Ashok, Anushruti [Academy of Scientific and Innovative Research (India); Developmental Toxicology, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research (CSIR-IITR) (India); Rai, Asit; Tripathi, Sachin [Developmental Toxicology, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research (CSIR-IITR) (India); Nagar, Geet Kumar [Endocrinology, CSIR-Central Drug Research Institute (CSIR-CDRI) (India); Mitra, Kalyan [Electron Microscopy Unit, CSIR-CDRI, Lucknow 226001 (India); Bandyopadhyay, Sanghamitra, E-mail: sanghmitra@iitr.res.in [Academy of Scientific and Innovative Research (India); Developmental Toxicology, Council of Scientific and Industrial Research-Indian Institute of Toxicology Research (CSIR-IITR) (India)

2013-12-01T23:59:59.000Z

389

Oxidation of sewage supernatant liquor by trickling filtration  

E-Print Network [OSTI]

', '': . . 195~9 ":, ' '59 9- ", 19. , -: '; '; 15'F9-;: . :: 418 ?: 499'' ', , : P "-. 8'~5, . : ?. ;. 159 9 . -', ::". , $9-. -:. . . : P P$3I8. :;. "-, . -. , :s8138: '439, ": . ::"::14i:, 9', . ::-', , '-- 4N ' -", ';, '. , :" XL' ". . -:, ' 14..., -. ;;. , ';. ;. . . XiqnM, :or es. crest. sn4-;~ss od As jskNsi' ':5xo, nsg4j~s's1'nips ?', :; . , "::, ' ', : digssegos emik mme-, el@, -er&kling-;Blear srs -eaiu nnies=smpg+sk'in ehs bra semsne. ok' ehs 'soles~, shd erssemiame nf ehs 1@n$4, 'rsspsnei'vole A eriohlkng...

Styner, Pete

1956-01-01T23:59:59.000Z

390

Multiple personality, a case study  

E-Print Network [OSTI]

. An exhaustive review of the literature revealed n& previous attempts at ut ilizing videotape therapy in the T. ea n&eni of rriultiple personali ty. Hnwever, via?. toping h&, s he, n !ncreosin&3!y llsea with great success in training therapists (Musan... personolity. Ir was also based on the past successes nf audio topes used in conjur!ation w!tn psychoanaiysis and hypnosis in the treat!nant of mal tip lr personalities. Following tt!e agree!nent to instItute videorape therapy inl. ! Ihe treat!ment plan...

Musick, William Daniel Anderson

1976-01-01T23:59:59.000Z

391

A hypothesis concerning the distribution of salt and salt structures in the Gulf of Mexico  

E-Print Network [OSTI]

. oils an. l domes on abyssal plain anil in Bay ot' Cainp che as surveyei. '. by iA'orzel et al. (1968). Inse t is cioss-section A-A' bas d cn. seismic refracton me" sure- ments (Eiving et al. , 1960; Antoine and Ev:ing, 1963) 26 Known and inferred...) shows a re tricted oattern in the central and south!vest. rn parts of the G!!1! of !nf xico. Th= v'ell-defined caste" n and s out( em boundari. s o. th-. kr!oil-and-dome province apparently are associated, w"th th cutline of the Can peche Bank. Th...

Antoine, John Woodworth

1970-01-01T23:59:59.000Z

392

Germination of yaupon (Ilex vomitoria Ait.) seed  

E-Print Network [OSTI]

!naast For. Er. p. Sta. , Asheville, N. C. 3 pp. Hur. . e, H. H. 1953. Ho! lies. The Hacr&illan Co. tier; York, N. Y. 242 pp. Ives, S. A. 1923. ?Iaturat. ion and germinacion of seed= of Iie', ; op&zom. Bot. Gaz. 76:60-77. Jensen, E. R. 1955. A study... of days required for various level nf germination of excised yaupon seed in response to gibberel]ic acid. 37 xiii LISl' OF FIGURES Figure 1. Longitudinal cross-sections ot yaupon seed -embryos harvested 9-15-66 (upper), and 3-15-67 (lower). 450X 2...

Fleming, Carl Michael

1970-01-01T23:59:59.000Z

393

Lipid Metabolism, Gene Expression, Substrate Oxidation, and Meat Quality of Growing-finishing Pigs Supplemented with Conjugated Linoleic Acid and Arginine  

E-Print Network [OSTI]

NRF-1 Nuclear respiratory factor 1 NF?B Nuclear factor-?B NO Nitric oxide NOS Nitric oxide synthase PGC-1 Peroxisome proliferator-activated receptor gamma coactivator 1 PPAR Peroxisome proliferator-activated receptor PSE Pale, soft... is necessary for mitochondrial biogenesis in response to oxidation of substrate. Hela cells, expressing eNOS, displayed increases in mitochondrial DNA content, cytochrome c oxidase, and the mRNA of PGC-1? and NRF-1 (32). Arginine increased CPT-1A and PGC-1...

Go, Gwang-Woong, 1979-

2012-02-14T23:59:59.000Z

394

Steer Feeding  

E-Print Network [OSTI]

COMMITTEE L. J. HART. Chairman J. S. WILLIAMS W. A. MILLER, JR. GOVERNING BOARD, STATE SUBSTATIONS ............................................................................ p L. DOWNS, President Temple.. Term expires 191%) C~ARLES ROGAN, Vice... ~fite ~heAist R. H. RIDGELL, S. As~i~f?nf Chemist SUBSTATION NO. 1: Beeville, Bee County FRANK HODGES. B. 3.. As.slstant Chemist E. E. BINFORD, B. S.. Superintendent W. T. P. SPROTT, B. S.. Ass~stant Chemist SUBSTATION NO. 2: T~~~~, smith county...

Burns, John C.

1915-01-01T23:59:59.000Z

395

Storage effects on desorption efficiencies of methyl ethyl ketone and styrene collected on activated charcoal  

E-Print Network [OSTI]

in the worker ' s breathir ng zone cont ir uously during his working day. Solid ad- sorbents are used almost exclusively I' or this type of sampling. Among the marr, adsorbents avail able (s ! i ca gel, activated alumina, Tenax, etc. } acti&!ated charcoa&1 I... efficier&cy nf methyl etiiy', Ketone and styrene monomer adsorbed on activated charcoal samples, and stored under isotherm&al condit'ions, were investigated as a function of storage time. The dependence of the storage time effects on the storage temp...

Dommer, Richard Alvin

1978-01-01T23:59:59.000Z

396

On Discrete Hyperbox Packing  

E-Print Network [OSTI]

22, 2006; revised November 23, 2006; approved by IEEE/ACM TRANSACTIONS ON NETWORKING Editor Z.-L. Zhang. The work of G. Xue, W. Zhang, and J. Tang was supported in part by the Army Research Office under Grant W911NF-04-1-0385 and by the National... State University, Tempe, AZ 85287-8809 USA (e-mail: xue@asu.edu). W. Zhang is with the Department of Computer Science, North Dakota State University, Fargo, ND 58105 USA (e-mail: weiyi.zhang@ndsu.edu). J. Tang is with the Department of Computer Science...

Li, Xiafeng

2010-01-14T23:59:59.000Z

397

Regional characteristics, timing, and significance of dissolution and collapse features in Lower Cretaceous carbonate platform strata, Desoto Canyon area, offshore Alabama-Florida  

E-Print Network [OSTI]

Crust ts rasota Arch Continental Crust Thick r s ional I'ust miles 100 200 0 100 200 km Boundaries between crustal types Figure 4. Structure map of the Pre-Louann basement in the study area. The map also shows the study area in relation... Cretaceous Unconformity James Limestone~ WILCOX MIOINAY Cl yl SELT IA McSh L r Euraw Tuacalooaa W P WILCOX Cia lon R play Bl fao n EUIaw I Ecalooaa L C *I 68 TARE TNANET141 rr / NF/ 1NN our clA/ CENO/ I N AN 3/ 6 r Paleocene...

Iannello, Christine

2012-06-07T23:59:59.000Z

398

The matching of polymer solution fast filament stretching, relaxation and break up experimental results with 1D and 2D numerical viscoelastic simulation  

E-Print Network [OSTI]

D. C. Vadillo*1, M. Tembely**2, N.F. Morrison3, O. G. Harlen3, M. R. Mackley1 10 and A. Soucemarianadin***2 11 12 1Department of Chemical Engineering and Biotechnology, University of Cambridge, 13 CB2 3RA, UK 14 2Laboratory for Geophysical... . Rasmussen, P-Y. Longin, and O. Hassager, Growth of non-635 axisymmetric disturbances of the free surface in the filament stretching rheometer: 636 Experiments and simulation, J. Non-Newtonian Fluid Mech. 180, 163186 (2002). 637 Bazilevsky A. V., V. M...

Vadillo, D.C.; Tembely, M.; Morrison, N.F.; Harlen, O.G.; Mackley, M.R.; Soucemarianadin, A.

399

Federal regulation of false advertising and other deceptive practices directed at the consumer  

E-Print Network [OSTI]

contcelling the preparation snd sale of foods and drugs nay have been caused by the inability nf governnent sgeacies to detect inpuri- g/ ties snd adulteration with any degree of validity. Thc need for valid nethods of detecting lnpurities stinulsted... willinR to insert ia his guns teeth pulle4 frou the jaws of 2/ ilupoverished youths ~ g~/C 1 L. A Wig. ~lt. , p. 117. g/R. S. Turner, e S s Ias. , New York, 1953, p. LS. A rtis, Ral lentine Rooks, Ia 1665, the year of the plague in Eaglaad, thoro...

Miner, George Edward

1962-01-01T23:59:59.000Z

400

First results from $2+1$ dynamical quark flavors on an anisotropic lattice: light-hadron spectroscopy and setting the strange-quark mass  

SciTech Connect (OSTI)

We present the first light-hadron spectroscopy on a set of $N_f=2+1$ dynamical, anisotropic lattices. A convenient set of coordinates that parameterize the two-dimensional plane of light and strange-quark masses is introduced. These coordinates are used to extrapolate data obtained at the simulated values of the quark masses to the physical light and strange-quark point. A measurement of the Sommer scale on these ensembles is made and the performance of the hybrid Monte Carlo algorithm used for generating the ensembles is estimated.

Lin, Huey-Wen; Cohen, Saul; Dudek, Jozef; Edwards, Robert; Joo, Balint; Richards, David; Bulava, John; Foley, Justin; Morningstar, Colin; Engelson, Eric; Wallace, Stephen; Juge, Jimmy; Mathur, Nilmani; Peardon, Michael; Ryan, Sinead

2009-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Absolute pollen influx and paleoenvironmental interpretations from Lake Wabamun, Alberta, Canada  

E-Print Network [OSTI]

in Paleocene lignite deposits from the area, Eleven radiocarbon dates were obtain- ed and yielded a basal date of 16, l80 years B. P. The eleven dates were all internally consistent. These above data, in con. junction with geologic, and soils evidence... frnz oucourag. ';tg rne Lo puzs r'. my gr;oduaLe care. . r in Botany. Fundir!g for a portion of this research wos p. c?vIrlcd by " grrnr from the Boreal Institu e. for Northern Studies, Uni?orsity nf Alberta. TABLE OF CONTENTS Page ABSTRACTS ~ I...

Holloway, Richard George

1978-01-01T23:59:59.000Z

402

Climax vegetation and soils of the Blackland Prairie of Texas  

E-Print Network [OSTI]

. I. o? Service whose personnel located potenI! al study sitcrs atrd us I sted with p! ant identif'ication and profile c!escripi iona. Mt. Dnn pard. 'I e- ton and Mr. Gordon McKee are ac:knowledged for. providing tnchr, rr al guidance. on plant... odlged for hi; ano, 'st. - an!e 'n the ii. "'' 1 p!tave of th'e t'ud, ' Mr. . snd Mxt . Te% Co11irs ere grat 1 ui1y aof! owleoged f!? choir moral aou finar! ial support nf this proj cr t! wi thout which th& o study could not have been completed...

Collins, Odell Brown

1972-01-01T23:59:59.000Z

403

Power Recovery  

E-Print Network [OSTI]

.POWER RECOVERY Fletcher Mlirray Monsanto Chemical Company AB5'-:::0 p.p., will ??vi.w 'h. '.ohnnln,y nf 'h.::v,n. T:X:~~T ~ methods for estimating the power recovery potential from fluid streams. The ideal gas law formula for expanding gases.... Gas Law Estimation Power recovery estimates from a vapor stream can be made using the formula: which is derived from the Ideal Gas Law. At first glance the. formula seems imposing and perhaps difficult to occasionally use. If however; the formula...

Murray, F.

404

A preliminary study of the distribution of some copepods in upper Laguna Madre  

E-Print Network [OSTI]

LIBRARY a a at cniiEr~ nF TExas A PRELIMINARY STUDY OF THE DISTRIBUTION OF SOME COPEPODS IN UPPER LAGUNA MADRE John C. Henderson A Thesis Submitted to the Graduate School of the Agricultural and Mechanical College of Texas in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE Mlny, io(R Ma/or Sub)ect: Oceanography A PRELIMINARY STUDY OF THE DISTRIBUTION OF SOME COPEPODS IN UPPER LAGUNA MADRE A Thesis John C. Henderson Approved as to style and content by: C...

Henderson, John C

1958-01-01T23:59:59.000Z

405

Approaching Conformality  

E-Print Network [OSTI]

We investigate the preconformal region of the phase diagram of SU(3) theories with fundamental flavors. We have simulated SU(3) theories with six and eight fundamental flavors at volumes 32^3 x 64. We use the generated configurations to measure the string tension \\sigma and the w0 scale setting quantity extracted from the gradient flow. We show preliminary results on the ratios Tc/\\sqrt{\\sigma} and Tc w0. We compare them to the behavior obtained at smaller Nf and discuss the implications of our results.

Maria Paola Lombardo; Kohtaroh Miura; Tiago Nunes da Silva; Elisabetta Pallante

2014-11-06T23:59:59.000Z

406

Life history and status of the olivaceous cormorant  

E-Print Network [OSTI]

LIFE HISTORY AND STATUS OF THE OLIVACFOUS CORMORANT A Thesis by MICHAEL LOUIS MORRISON Submi t ted to the Graduate Col '1 ege nf Texas A~M University in par. jal ful f i 1 jm. . nt of the r equi r, ment fc the d gree of MASTER OF SCIENCE... Oecember 1 977 I, ( jo" Sul-, jey, Nj jdj if ayd y js ' yves 5 jane os LIFE HISTORY AND STATUS OF THE OLIVACEOUS CORMORANT A Thesis by MICHAEL LOUIS MORRISON Approved as to style and content by: Chairma of Committee Member ea of Department Me ber...

Morrison, Michael Louis

1977-01-01T23:59:59.000Z

407

Electromagnetic corrections to pseudoscalar decay constants  

E-Print Network [OSTI]

The effects of electromagnetic interactions on pseudoscalar decay constants are investigated. Using a compact QED and QCD action we are able to resolve differences of about 0.1 MeV. We obtain the preliminary results f_pi^0-f_pi^+/- =0.09(3) MeV and f_D^0-f_D^+/- =0.79(11) MeV for light and charmed pseudoscalar decay constants on a N_f=2 nonperturbatively improved Sheikholeslami-Wohlert ensemble.

Benjamin Glaessle; Gunnar S. Bali

2011-11-16T23:59:59.000Z

408

Anger camera image generation with microcomputers  

E-Print Network [OSTI]

ANGER CAMERA IMAGE GENERATJON WITH iMICR0C0MPJJTERS A Thesis R, 'RI. MGVGAN NIJ. J. IAPLS SubiniL', ti tc: tbe ' taNua - CnlILEr nf Hnivetui ty ;-'r' Lal . '. . '. 6i', i. -ent oL th: ie9uite. . ;List. )i Lhe 4 El'. : ol MASTER 09 SC ENCE May... that with the u e of an innovat ive 'nterfsce system and appropriate software, a microcomputer was a). le tc acquire, display, and analyze Anger came;a images. The interface board designed for this projec. includes A ? D convert. era, a wo page memory system...

Williams, Karl Morgan

1988-01-01T23:59:59.000Z

409

Scion dominance and related factors influencing compatability in citrus graft unions  

E-Print Network [OSTI]

SCION DOMINANCE AND RELATED FACTORS INFLUENCING COMPATIBILITY IN CITRUS GRAFT UNIOHS A The?ia SC H? Clntr&i August 194C Approval as to atyl* and content recommended* m t m m m m m m belated factors nfHOTQiua compatibilitt in cithus m m r... Major Subjectt Horticulture By Rafael H* Clntr&n August 1946 SCI01T DOHIH/ffiCB AND RELATED FACTORS INFLUENCING COMPATIBILITY ITT CITRUS GR APT UNIONS 14-f 706 'The writer1 wishes to express M s sincere approeiation to Dr* Guy W? Adrianee# Head...

Cintron, Rafael H.

1946-01-01T23:59:59.000Z

410

Determination of fracture and reservoir properties using an automatic history matching technique for wells with finite-conductivity vertical fractures  

E-Print Network [OSTI]

. Figure 4 shows the comparison of trilinear model constant pressure case solutions with the Agarwal et al. numerical solution. The results indicate that the models match over the entire S LCC CL' u) bJ CD CIJ 4 CD FD - 0. 2IT, FD 0 ' 2TT FD... 18 DIMENSIONLESS TIME Fig. 8 - Effect of Fracture Diffusivity at Early Time 14 ]2 LLI CL ]0 8 LLI K Io True Solution I/n = 0, 0 f True Solution, nf ? 106 parameters S = 10. 0 FD = IOII CLI = 00 10 DIMENSIDNLESS TIME Fig. 9 - Effect...

Santhanam, Kalakad Sundhareswaraiyer

1985-01-01T23:59:59.000Z

411

ORNL/RASA-85/1 RESULTS OF THE II4OBILE GAMMA SCANNING ACTIVITIES IN NIAGARA FALLS, NEvl YORK AREA  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofofOxford SiteToledo SiteTonawandaUniversity21 theB 4q-utSPJ\Nf7 n-q

412

ORNL/RASA-86/ L9  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofofOxford SiteToledo SiteTonawandaUniversity21 theB 4q-utSPJ\Nf7 n-qQq

413

ORNL/RASA-86/65  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofofOxford SiteToledo SiteTonawandaUniversity21 theB 4q-utSPJ\Nf7

414

ORNL/RASA-86/66  

Office of Legacy Management (LM)

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415

ORNL/RASA-86/67  

Office of Legacy Management (LM)

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416

ORNL/RASA-86/71  

Office of Legacy Management (LM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofofOxford SiteToledo SiteTonawandaUniversity21 theB 4q-utSPJ\Nf76771

417

Section 27  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systemsBi (2) Sr (2)ScienceScientistsONDelivered5AtmosphericOn the5ExpertNF

418

Determination of naphthenic acids in California crudes and refinery waste waters by fluoride ion chemical ionization mass spectrometry  

SciTech Connect (OSTI)

A method based on negative ion chemical ionization mass spectrometry using fluoride (F/sup -/) ions produced from NF/sub 3/ reagent gas has been applied to the analysis of naphthenic acids in California crude oils and refinery waste waters. Since complex mixtures of naphthenic acids cannot be separated into individual components, only the determination of relative distribution of acids classified by the hydrogen deficiency was possible. The identities and relative distribution of paraffinic and mono-, di-, tri, and higher polycyclic acids were obtained from the intensities of the carboxylate (RCOO/sup -/) ions.

Dzidic, I.; Somerville, A.C.; Raia, J.C.; Hart, H.V.

1988-07-01T23:59:59.000Z

419

Nickel-induced down-regulation of {Delta}Np63 and its role in the proliferation of keratinocytes  

SciTech Connect (OSTI)

Epidemiological, animal, and cell studies have demonstrated that nickel compounds are human carcinogens. The mechanisms of their carcinogenic actions remain to be investigated. p63, a close homologue of the p53 tumor suppressor protein, has been linked to cell fate determination and/or maintenance of self-renewing populations in several epithelial tissues, including skin, mammary gland, and prostate. {Delta}Np63, a dominant negative isoform of p63, is amplified in a variety of epithelial tumors including squamous cell carcinomas and carcinomas of the prostate and mammary glands. The present study shows that nickel suppressed {Delta}Np63 expression in a short-time treatment (up to 48 h). Nickel treatment caused activation of NF-{kappa}B. Blockage of NF-{kappa}B partially reversed nickel-induced {Delta}Np63 suppression. Nickel decreased interferon regulatory factor (IRF) 3 and IRF7, IKK{epsilon}, and Sp100. Over-expression of IRF3 increased {Delta}Np63 expression suppressed by nickel. Nickel was able to activate p21, and its activation was offset by the over-expression of {Delta}Np63. In turn, elevated p63 expression counteracted the ability of nickel to restrict cell growth. The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF-{kappa}B, resulting in {Delta}Np63 suppression and then p21 up-regulation. {Delta}Np63 plays an important role in nickel-induced cell proliferation. - Highlights: > Ni suppressed {Delta}Np63 expression in HaCat cells. > Ni activated NF-{kappa}B, decreased expressions of IRF3 and IRF7, IKK{epsilon}, and Sp100. > Over-expression of IRF3 increased {Delta}Np63 expression suppressed by Ni. > Ni activated p21, and its activation was offset by over-expression of {Delta}Np63. > Elevated p63 expression counteracted the ability of nickel to restrict cell growth.

Zhang Zhuo, E-mail: zhuo.zhang@uky.edu [Department of Preventive Medicine and Environmental Health, University of Kentucky, 121 Washington Avenue, Lexington, KY 40536 (United States); Li Wenqi [Department of Preventive Medicine and Environmental Health, University of Kentucky, 121 Washington Avenue, Lexington, KY 40536 (United States); Cheng Senping [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY 40536 (United States); Yao Hua [Department of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003 (China); Zhang Fan; Chang Qingshan [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY 40536 (United States); Ke Zunji [Department of Internal Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 (United States); Wang Xin; Son, Young-Ok [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY 40536 (United States); Luo Jia [Department of Internal Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 (United States); Shi Xianglin [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY 40536 (United States)

2011-06-15T23:59:59.000Z

420

A conversational Chinese Tutoring Machine  

E-Print Network [OSTI]

CAI (LAMBDA NIL (PROG1 (SET PARA) (CAIM07) (CAIM03) (CLRSCRN) (PRINTX '(Thanks for joining the Chinese Tutoring Machine) 9 15) (PRINTX '(bye bye !) 11 35) ) )) t*'0 '0'0************'k 'k*****V '@*It%'**'k**'k****'k**'@**1k *ll 'Nf****'k 0 'kt... **'0 * FUNCTION : CAIM03 This is the main driver function for lesson section. ***4'***1@*'0 4 4 'P * a%****'k 'k****'0**4 *V k*%**%'**%********%'**'I*V 4 4*** (DEFUN CAIM03 (LAMBDA NIL ( PROG1 (CAIM04) (COND ((EQUAL RES 'E) T) (T (CAIM05) (CAIM...

Cheng, Long-Fung

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
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421

Non-Abelian Webs of Walls  

E-Print Network [OSTI]

Domain wall junctions are studied in N=2 supersymmetric U(Nc) gauge theory with Nf(>Nc) flavors. We find that all three possibilities are realized for positive, negative and zero junction charges. The positive junction charge is found to be carried by a topological charge in the Hitchin system of an SU(2) gauge subgroup. We establish rules of the construction of the webs of walls. Webs can be understood qualitatively by grid diagram and quantitatively by associating moduli parameters to web configurations.

Minoru Eto; Youichi Isozumi; Muneto Nitta; Keisuke Ohashi; Norisuke Sakai

2005-09-15T23:59:59.000Z

422

Determination of the properties of nuclear energy levels using resonance-scattered neutron capture gamma rays  

E-Print Network [OSTI]

GETElc&ii!'iV! cbN O. ' '! IE FROPENT1ES OF NUCI. EAIl El(E"". GY I. EYEc S USING GESOlIANCE-SCATTEIIEG NE'll'HGN . APTUPZ GAIIMA RAYS A !iles ls IU!Sb "ebb A. Mc. COFci!1CK SubmitteU to the Graclua!. e Colleoo or" Texas Afoul&! Uniser ity... RUSSELL A. PicCOPMTCK Approved "s to stylo and content I?: (CiInirman oE Coaaaittoe V (Member plead nf Dep, . tmont) P! v. oer) (Member) Ma&, l968 Detemsination of the properties of Nuclear Bnergy Lese is Osi: 6 Resonance-Scattered deut...

McCormick, Russell A

1968-01-01T23:59:59.000Z

423

Microsoft Word - RL14788-Section_F_197.doc  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment SurfacesResource Program Preliminary Needs Assessment March 2009 B O N NB O NF

424

CACA-014408 | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating SolarElectricEnergyCTBarreis a city in Chittenden County,47 Geothermal0 BidINYO NF

425

NGP Energy Technology Partners | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF Energy Saving CorpNGP

426

NM Stat. 62-9 - The Utility Franchise | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNM Stat. 62-9 -

427

NM Underground Storage Tank Registration | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNM Stat. 62-9

428

NMAC 20.2.72 Air Quality Construction Permits | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurrInformation NAMA-ProgrammeNF EnergyNMCapacity2 Air

429

NMDOT Utility Permit Application Checklist | Open Energy Information  

Open Energy Info (EERE)

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430

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

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431

The behavior of a multidimensional rainfall model through an annual cycle in the Brazos Valley  

E-Print Network [OSTI]

rate of the storm is denoted by the parameter I. The number of bursts per storm ss identically and independently dkstrtbuted with a pa? eter nf v The depth assocsated wsth each burst is also identically and independently dkstributed with s, parameter... 01 min The density of cluster potential centers per rainband expressed in CPC's/km Range 0 01 to 0. 0001 into The rainfall intensity at the birth center and birth time of the raincell. In the exponential decay situation used in this model...

Koepsell, Royal Warren

1989-01-01T23:59:59.000Z

432

Baryon resonances coupled to Pion-Nucleon states in lattice QCD  

E-Print Network [OSTI]

In recent years the study of two particle systems on the lattice has led to excellent results in the meson sector of the QCD spectrum, however baryon resonances mostly remain unexplored. We present a study of pion-nucleon systems as decay product of baryon resonances in different channels, with special focus on the nucleon spectrum. We evaluate the correlation functions of single and multi particle interpolators. All the Wick contributions are explicitly computed and the consequences of reduced symmetries in moving frames are taken into account. We discuss the theoretical setup together with results for $n_f=2$ mass degenerate light quarks.

Verduci, Valentina

2014-01-01T23:59:59.000Z

433

The oncoprotein HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote the proliferation of breast cancer cells  

SciTech Connect (OSTI)

Highlights: HBXIP is able to upregulate the expression of PDGFB in breast cancer cells. HBXIP serves as a coactivator of activating transcription factor Sp1. HBXIP stimulates the PDGFB promoter via activating transcription factor Sp1. HBXIP promotes the proliferation of breast cancer cell via upregulating PDGFB. -- Abstract: We have reported that the oncoprotein hepatitis B virus X-interacting protein (HBXIP) acts as a novel transcriptional coactivator to promote proliferation and migration of breast cancer cells. Previously, we showed that HBXIP was able to activate nuclear factor-?B (NF-?B) in breast cancer cells. As an oncogene, the platelet-derived growth factor beta polypeptide (PDGFB) plays crucial roles in carcinogenesis. In the present study, we found that both HBXIP and PDGFB were highly expressed in breast cancer cell lines. Interestingly, HBXIP was able to increase transcriptional activity of NF-?B through PDGFB, suggesting that HBXIP is associated with PDGFB in the cells. Moreover, HBXIP was able to upregulate PDGFB at the levels of mRNA, protein and promoter in the cells. Then, we identified that HBXIP stimulated the promoter of PDGFB through activating transcription factor Sp1. In function, HBXIP enhanced the proliferation of breast cancer cells through PDGFB in vitro. Thus, we conclude that HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote proliferation of breast cancer cells.

Zhang, Yingyi; Zhao, Yu; Li, Leilei; Shen, Yu; Cai, Xiaoli [Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China); Ye, Lihong, E-mail: yelihong@nankai.edu.cn [Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China)

2013-05-03T23:59:59.000Z

434

Repulsive nature of optical potentials for high-energy heavy-ion scattering  

E-Print Network [OSTI]

The recent works by the present authors predicted that the real part of heavy-ion optical potentials changes its character from attraction to repulsion around the incident energy per nucleon E/A = 200 - 300 MeV on the basis of the complex G-matrix interaction and the double-folding model (DFM) and revealed that the three-body force plays an important role there. In the present paper, we have precisely analyzed the energy dependence of the calculated DFM potentials and its relation to the elastic-scattering angular distributions in detail in the case of the $^{12}$C + $^{12}$C system in the energy range of E/A = 100 - 400 MeV. The tensor force contributes substantially to the energy dependence of the real part of the DFM potentials and plays an important role to lower the attractive-to-repulsive transition energy. The nearside and farside (N/F) decomposition of the elastic-scattering amplitudes clarifies the close relation between the attractive-to-repulsive transition of the potentials and the characteristic evolution of the calculated angular distributions with the increase of the incident energy. Based on the present analysis, we propose experimental measurements of the predicted strong diffraction phenomena of the elastic-scattering angular distribution caused by the N/F interference around the attractive-to-repulsive transition energy together with the reduced diffractions below and above the transition energy.

T. Furumoto; Y. Sakuragi; Y. Yamamoto

2010-10-08T23:59:59.000Z

435

Heavy-quark free energy at finite temperature with 2+1 flavors of improved Wilson quarks in fixed scale approach  

E-Print Network [OSTI]

The free energy between a static quark and an antiquark is studied by using the color-singlet Polyakov-line correlation at finite temperature. We perform simulations on $32^3 \\times 12$, 10, 8, 6, 4 lattices in the high temperature phase with the RG-improved gluon action and 2+1 flavors of the clover-improved Wilson quark action. Since the simulations are based on the fixed scale approach that the temperature can be varied without changing the spatial volume and renormalization factor, it is possible to investigate temperature dependence of the heavy-quark free energy without any adjustment of the overall constant. We find that, the heavy-quark free energies at short distance converge to the heavy-quark potential evaluated from the Wilson-loop operator at zero temperature, in accordance with the expected insensitivity of short distance physics to the temperature. At long distance, the heavy-quark free energies approach to twice the single-quark free energies, implying that the interaction between heavy quarks is screened. The Debye screening mass obtained from the long range behavior of the heavy-quark free energy is compared with results of the thermal perturbation theory and those of $N_f=2$ and $N_f=0$ lattice simulations.

Y. Maezawa; S. Aoki; S. Ejiri; T. Hatsuda; K. Kanaya; H. Ohno; T. Umeda

2009-11-02T23:59:59.000Z

436

Nepali Aawaz Volume 1, Issue 4, 9-22 November 2005  

E-Print Network [OSTI]

M 5'6\\sf/f lnO/x]sf] 5 . 8fo:kf]/faf6 rf8jf8 dfGg :jb]z kms]{sfx? klg cj ljbfjf/L eP/ cfcfkm\\gf] sd{If]qlt/ nfUg yfn]sf 5g\\ . dfcf]jfbLsf] o'4lj/fdsf sf/0f zx/af6 bz}ltxf/ dfGg ufpFlt/ nfu]sfx? klg zx/lt/ kms{g] qmd hf/L 5 . z/b Ct'sf] ;'Gb/ a... 'b} hfFbf pgLx?sf] o; sdhf]/Laf6 kmfObf p7fpg ljb]zL zlQmsf] if8oGq z'? eO;s]sf] 5 . o;}n] d"nssf] lxtsf] nflu slQ klg l9nf] gu/L /fhf, bn / ljb|f

Shrestha, Kashish Das

437

Nepali Aawaz Volume 1, Issue 19, 7 December 2006  

E-Print Network [OSTI]

democratic failure can only be evaluated by reviewing historical, social and economic factors. Digital Himalaya klZrddf juL{o ;+3if{sf] gf/f lbP/ ;kmn ePsf dfcf]jfbLnfO{ k"j{df k|e'Tj hfpg klxNo}b]lv hftLo gf/f rsf{pFb} cPsf] ljb|f]xL /fO{lnDa"x... O{eL ;+qmldtx?nfO{ Pslqt u/L d[To'sf] cft+s leq ;'Gb/ hLjgsf] vf]hL ul//x]sf5g\\ . @)%* ;fndf k'jf{~rn If]qd} klxnf] k6s cfkm'nfO{ PrcfO{eL ;+qm- dLt 3f]if0ff ub}{ ;+qmdLtx?sf] xs clwsf/sf] kIfdf cfjfh p7fpb} ;fj{hgLs ePsf g/]z eG5g ;'?df ;+qmdLt eGbf dfgL;x...

Shrestha, Kashish Das

438

Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models  

SciTech Connect (OSTI)

Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat models. Results showed that MP and EP caused reduction of carrageenan-induced rat paw edema in addition to diminishing prostaglandin E2 (PGE2) level in the inflammatory exudates. In lipopolysaccharide (LPS)-induced endotoxemia in rats, MP and EP reduced plasma levels of tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6). MP and EP decreased NF-?B expression in liver and lung tissues and ameliorated histopathological changes caused by LPS. Topical application of MP and EP reduced ear edema induced by croton oil in rats. In the same animal model, MP and EP reduced neutrophil infiltration, as indicated by decreased myeloperoxidase (MPO) activity. In conclusion, this study demonstrates the effectiveness of MP and EP in combating inflammation in several experimental models. -- Highlights: ? Efficacy of MP and EP in combating inflammation was displayed in several models. ? MP and EP reduced carrageenan-induced rat paw edema and prostaglandin E2 level. ? MP and EP decreased TNF-? and IL-6 levels in experimental endotoxemia. ? MP and EP reduced NF-?B expression and histological changes in rat liver and lung. ? MP and EP reduced croton oil-induced ear edema and neutrophil infiltration.

Saeed, Noha M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt); El-Demerdash, Ebtehal [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); Abdel-Rahman, Hanaa M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt); Algandaby, Mardi M. [Department of Biology (Botany), Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Biology (Botany), Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia); Al-Abbasi, Fahad A. [Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia); Abdel-Naim, Ashraf B., E-mail: abnaim@pharma.asu.edu.eg [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)

2012-10-01T23:59:59.000Z

439

Id1 expression promotes peripheral CD4{sup +} T cell proliferation and survival upon TCR activation without co-stimulation  

SciTech Connect (OSTI)

Highlights: Id1 expression enables nave T cell proliferation without anti-CD28 co-stimulation. Id1 expression facilitates T cells survival when stimulated with anti-CD3. Elevation of IL-2 production by Id1 contributes increased proliferation and survival. Id1 potentiates NF-?B activation by anti-CD3 stimulation. -- Abstract: Although the role of E proteins in the thymocyte development is well documented, much less is known about their function in peripheral T cells. Here we demonstrated that CD4 promoter-driven transgenic expression of Id1, a naturally occurring dominant-negative inhibitor of E proteins, can substitute for the co-stimulatory signal delivered by CD28 to facilitate the proliferation and survival of nave CD4{sup +} cells upon anti-CD3 stimulation. We next discovered that IL-2 production and NF-?B activity after anti-CD3 stimulation were significantly elevated in Id1-expressing cells, which may be, at least in part, responsible for the augmentation of their proliferation and survival. Taken together, results from this study suggest an important role of E and Id proteins in peripheral T cell activation. The ability of Id proteins to by-pass co-stimulatory signals to enable T cell activation has significant implications in regulating T cell immunity.

Liu, Chen; Jin, Rong [Department of Immunology, Peking University Health Science Center, Beijing (China)] [Department of Immunology, Peking University Health Science Center, Beijing (China); Wang, Hong-Cheng [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States)] [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States); Tang, Hui; Liu, Yuan-Feng; Qian, Xiao-Ping; Sun, Xiu-Yuan; Ge, Qing [Department of Immunology, Peking University Health Science Center, Beijing (China)] [Department of Immunology, Peking University Health Science Center, Beijing (China); Sun, Xiao-Hong, E-mail: sunx@omrf.org [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States)] [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States); Zhang, Yu, E-mail: zhangyu007@bjmu.edu.cn [Department of Immunology, Peking University Health Science Center, Beijing (China)] [Department of Immunology, Peking University Health Science Center, Beijing (China)

2013-06-21T23:59:59.000Z

440

Structure functions for light nuclei  

SciTech Connect (OSTI)

We discuss the nuclear EMC effect with particular emphasis on recent data for light nuclei including 2H, 3He, 4He, 9Be, 12C and 14N. In order to verify the consistency of available data, we calculate the \\chi^2 deviation between different data sets. We find a good agreement between the results from the NMC, SLAC E139, and HERMES experiments. However, our analysis indicates an overall normalization offset of about 2% in the data from the recent JLab E03-103 experiment with respect to previous data for nuclei heavier than 3He. We also discuss the extraction of the neutron/proton structure function ratio F2n/F2p from the nuclear ratios 3He/2H and 2H/1H. Our analysis shows that the E03-103 data on 3He/2H require a renormalization of about 3% in order to be consistent with the F2n/F2p ratio obtained from the NMC experiment. After such a renormalization, the 3He data from the E03-103 data and HERMES experiments are in a good agreement. Finally, we present a detailed comparison between data and model calculations, which include a description of the nuclear binding, Fermi motion and off-shell corrections to the structure functions of bound proton and neutron, as well as the nuclear pion and shadowing corrections. Overall, a good agreement with the available data for all nuclei is obtained.

S.A. Kulagin, R. Petti

2010-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Toward a Holographic Model of Superconducting Fermions  

E-Print Network [OSTI]

We use the AdS/CFT correspondence to study N=4 supersymmetric SU(Nc) Yang-Mills theory, in the limits of large Nc and large 't Hooft coupling, coupled to a number Nf of massless hypermultiplet fields in the fundamental representation of the gauge group. We identify a U(1) subgroup of the R-symmetry under which the fermions in the hypermultiplet are charged but the scalars are not. All the hypermultiplet fields are also charged under a U(1) baryon number symmetry. We introduce an external magnetic field for the baryon number U(1), which triggers the spontaneous breaking of the U(1) R-symmetry, and we then introduce a chemical potential for the U(1) R-charge, producing a state with a nonzero density of the U(1) R-charge. The system should then exhibit superconductivity of the U(1) R-charge. The dual supergravity description is a number Nf of D7-branes in AdS5 x S5 with angular momentum on the S5 and a worldvolume magnetic field. We study the zero-temperature thermodynamics of the system, and find that for sufficiently large magnetic field the system prefers to be in the symmetry-broken phase. For smaller magnetic fields we find a discontinuous free energy, indicating that our gravitational setup does not capture all equilibrium states of the field theory.

Andy O'Bannon

2008-11-02T23:59:59.000Z

442

Etching process of silicon dioxide with nonequilibrium atmospheric pressure plasma  

SciTech Connect (OSTI)

An ultrahigh etch rate (14 {mu}m/min) of SiO{sub 2} and a high selectivity of SiO{sub 2}/Si over 200 were achieved using a microwave-excited nonequilibrium atmospheric pressure plasma source employing He, NF{sub 3}, and H{sub 2}O gases, which have been developed for application to microelectromechanical systems and other bionanotechnology fields. In order to clarify the etching mechanism, two diagnostic methods have been performed: (1) imaging of plasma emission with an intensified charge-coupled device camera, and (2) absorption measurements using Fourier transform infrared spectroscopy. The etching characteristics are discussed in relation to the spatial distributions of the species involved. The etch rate depended considerably on the distance between the plasma and the substrate. Some radicals generated from the feed gases reached the substrate directly, while other radicals recombined into different species, which reached the substrate. An abundance of HF molecules were produced through a reaction between radicals generated by the atmospheric pressure discharge of NF{sub 3} and H{sub 2}O. From these measurements, it has been found that the HF molecules generated played a role in producing the high etch rate of SiO{sub 2} and high etch selectivity of SiO{sub 2}/Si.

Yamakawa, Koji; Hori, Masaru; Goto, Toshio; Den, Shoji; Katagiri, Toshirou; Kano, Hiroyuki [Department of Quantum Engineering, Nagoya University, Furo-Cho, Chikusa-ku, Nagoya 464-8603 (Japan); Department of Electrical Engineering and Computer Science, Nagoya University, Furo-Cho, Chikusa-ku, Nagoya 464-8603 (Japan); Department of Quantum Engineering, Nagoya University, Furo-Cho, Chikusa-ku, Nagoya 464-8603 (Japan); Department of Engineering, Katagiri Engineering Co., Ltd., Minamikase Saiwai-ku, Kawasaki 661-8661 (Japan); NU-EcoEngineering Co., Ltd., Ooaza, Kurozasa Aza, Umazutsumi, Miyoshi-cho, Nishikamo-gun, Aichi 470-0201 (Japan)

2005-07-01T23:59:59.000Z

443

A multichannel magnetic probe system for analysing magnetic fluctuations in helical axis plasmas  

SciTech Connect (OSTI)

The need to understand the structure of magnetic fluctuations in H-1NF heliac [S. Hamberger et al., Fusion Technol. 17, 123 (1990)] plasmas has motivated the installation of a sixteen former, tri-axis helical magnetic probe Mirnov array (HMA). The new array complements two existing poloidal Mirnov arrays by providing polarisation information, higher frequency response, and improved toroidal resolution. The helical placement is ideal for helical axis plasmas because it positions the array as close as possible to the plasma in regions of varying degrees of favourable curvature in the magnetohydrodynamic sense, but almost constant magnetic angle. This makes phase variation with probe position near linear, greatly simplifying the analysis of the data. Several of the issues involved in the design, installation, data analysis, and calibration of this unique array are presented including probe coil design, frequency response measurements, mode number identification, orientation calculations, and mapping probe coil positions to magnetic coordinates. Details of specially designed digitally programmable pre-amplifiers, which allow gains and filters to be changed as part of the data acquisition initialisation sequence and stored with the probe signals, are also presented. The low shear heliac geometry [R. Jimnez-Gmez et al., Nucl. Fusion 51, 033001 (2011)], flexibility of the H-1NF heliac, and wealth of information provided by the HMA create a unique opportunity for detailed study of Alfvn eigenmodes, which could be a serious issue for future fusion reactors.

Haskey, S. R.; Blackwell, B. D.; Seiwald, B.; Hole, M. J.; Pretty, D. G.; Howard, J.; Wach, J. [Plasma Research Laboratory, Research School of Physical Sciences and Engineering, The Australian National University, Canberra, ACT 0200 (Australia)] [Plasma Research Laboratory, Research School of Physical Sciences and Engineering, The Australian National University, Canberra, ACT 0200 (Australia)

2013-09-15T23:59:59.000Z

444

Compatibility Assessment of Advanced Stainless Steels in Sodium  

SciTech Connect (OSTI)

Type 316L stainless steel capsules containing commercially pure sodium and miniature tensile specimens of HT-UPS (austenitic, 14Cr-16Ni), NF-616 (ferritic/martensitic, 9Cr-2W-0.5Mo), or 316L (austenitic, 17Cr-10Ni-2Mo) stainless steel were exposed at 600 or 700 C for 100 and 400 h as a screening test for compatibility. Using weight change, tensile testing, and metallographic analysis, HT-UPS and 316L were found to be largely immune to changes resulting from sodium exposure, but NF-616 was found susceptible to substantial decarburization at 700 C. Subsequently, two thermal convection loops (TCLs) constructed of 316L and loaded with commercially pure sodium and miniature tensile specimens of HT-UPS and 316L were operated for 2000 h each one between 500 and 650 C, the other between 565 and 725 C at a flow rate of about 1.5 cm/s. Changes in specimen appearance, weight, and tensile properties were observed to be very minor in all cases, and there was no metallographic evidence of microstructure changes, composition gradients, or mass transfer resulting from prolonged exposure in a TCL. Thus, it appears that HT-UPS and 316L stainless steels are similarly compatible with commercially pure sodium under these exposure conditions.

Pawel, Steven J [ORNL

2012-01-01T23:59:59.000Z

445

Silver Blaze Puzzle in 1/Nc Expansions of Cold and Dense QCD Matter  

E-Print Network [OSTI]

We consider quantum chromodynamics (QCD) with Nc colors and Nf quark flavors at finite quark chemical potential mu_q or isospin chemical potential mu_I. We specifically address the nature of the ``Silver Blaze'' behavior in the framework of 1/Nc expansion. Starting with the QCD partition function, we implement Veneziano's Nf/Nc expansion to identify the density onset. We find the baryon mass M_B and the pion mass m_pi appearing from different order of Veneziano's expansion. We argue that the confining properties are responsible for the Silver Blaze in the region of m_pi/2 < mu_q < M_B/Nc. We point out, however, that Veneziano's expansion brings about a puzzling subtlety along the same line as the baryon problem in finite-density quenched simulations. We emphasize that the large-Nc limit can allow for the physical ordering of M_B and m_pi thanks to the similarity to the quenched approximation, while the unphysical ghost quarks contaminate the baryon sector if Nc is finite. We also discuss the ``orientifold'' large-Nc limit that does not quench quark loops.

Adi Armoni; Kenji Fukushima

2014-03-10T23:59:59.000Z

446

DRAFT - Design of Radiological Survey and Sampling to Support Title Transfer or Lease of Property on the Department of Energy Oak Ridge Reservation  

SciTech Connect (OSTI)

The U.S. Department of Energy (DOE) owns, operates, and manages the buildings and land areas on the Oak Ridge Reservation (ORR) in Oak Ridge, Tennessee. As land and buildings are declared excess or underutilized, it is the intent of DOE to either transfer the title of or lease suitable property to the Community Reuse Organization of East Tennessee (CROET) or other entities for public use. It is DOE's responsibility, in coordination with the U.S. Environmental Protection Agency (EPA), Region 4, and the Tennessee Department of Environment and Conservation (TDEC), to ensure that the land, facilities, and personal property that are to have the title transferred or are to be leased are suitable for public use. Release of personal property must also meet site requirements and be approved by the DOE contractor responsible for site radiological control. The terms title transfer and lease in this document have unique meanings. Title transfer will result in release of ownership without any restriction or further control by DOE. Under lease conditions, the government retains ownership of the property along with the responsibility to oversee property utilization. This includes involvement in the lessee's health, safety, and radiological control plans and conduct of site inspections. It may also entail lease restrictions, such as limiting access to certain areas or prohibiting digging, drilling, or disturbing material under surface coatings. Survey and sampling requirements are generally more rigorous for title transfer than for lease. Because of the accelerated clean up process, there is an increasing emphasis on title transfers of facilities and land. The purpose of this document is to describe the radiological survey and sampling protocols that are being used for assessing the radiological conditions and characteristics of building and land areas on the Oak Ridge Reservation that contain space potentially available for title transfer or lease. After necessary surveys and sampling and laboratory analyses are completed, the data are analyzed and included in an Environmental Baseline Summary (EBS) report for title transfer or in a Baseline Environmental Analysis Report (BEAR) for lease. The data from the BEAR is then used in a Screening-Level Human Health Risk Assessment (SHHRA) or a risk calculation (RC) to assess the potential risks to future owners/occupants. If title is to be transferred, release criteria in the form of specific activity concentrations called Derived Concentration Guideline Levels (DCGLs) will be developed for the each property. The DCGLs are based on the risk model and are used with the data in the EBS to determine, with statistical confidence, that the release criteria for the property have been met. The goal of the survey and sampling efforts is to (1) document the baseline conditions of the property (real or personal) prior to title transfer or lease, (2) obtain enough information that an evaluation of radiological risks can be made, and (3) collect sufftcient data so that areas that contain minimal residual levels of radioactivity can be identified and, following radiological control procedures, be released from radiological control. (It should be noted that release from radiological control does not necessarily mean free release because DOE may maintain institutional control of the site after it is released from radiological control). To meet the goals of this document, a Data Quality Objective (DQO) process will be used to enhance data collection efficiency and assist with decision-making. The steps of the DQO process involve stating the problem, identifying the decision, identifying inputs to the decision, developing study boundaries, developing the decision rule, and optimizing the design. This document describes the DQOs chosen for surveys and sampling efforts performed for the purposes listed above. The previous version to this document focused on the requirements for radiological survey and sampling protocols that are be used for leasing. Because the primary focus at this time is on title transfer, th

Cusick L.T.

2002-09-25T23:59:59.000Z

447

Interaction of inflammatory and anti-inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid  

SciTech Connect (OSTI)

We investigated the interaction between proinflammatory and inflammatory responses caused by Staphylococcus aureus-derived lipoteichoic acid (LTA) in primary cultured microglial cells and BV-2 microglia. LTA induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein levels increase in a concentration- and time-dependent manner. Meanwhile, LTA also increased nitric oxide (NO) and PGE{sub 2} production in microglia. Administration of TLR2 antagonist effectively inhibited LTA-induced NO, iNOS, and COX-2 expression. Moreover, treatment of cells with LTA caused a time-dependent activation of ERK, p38, JNK, as well as AKT. We also found that LTA-induced iNOS and COX-2 up-regulation were attenuated by p38, JNK, and PI3-kinase inhibitors. On the other hand, LTA-enhanced HO-1 expression was attenuated by p38 and PI3-kinase inhibitors. Treatment of cells with NF-?B and AP-1 inhibitors antagonized LTA-induced iNOS and COX-2 expression. However, only NF-?B inhibitors reduced LTA-induced HO-1 expression in microglia. Furthermore, stimulation of cells with LTA also activated I?B? phosphorylation, p65 phosphorylation at Ser{sup 536}, and c-Jun phosphorylation. Moreover, LTA-induced increases of ?B-DNA and AP-1-DNA binding activity were inhibited by p38, JNK, and PI3-kinase inhibitors. HO-1 activator CoPP IX dramatically reversed LTA-induced iNOS expression. Our results provided mechanisms linking LTA and inflammation/anti-inflammation, and indicated that LTA plays a regulatory role in microglia activation. - Highlights: LTA causes an increase in iNOS, COX-2, and HO-1 expression in microglia. LTA induces iNOS and COX-2 expression through TLR-2/NF-?B and AP-1 pathways. HO-1 expression is regulated through p38, JNK, PI3K/AKT and AP-1 pathways. Induced HO-1 reduces LTA-induced iNOS expression. LTA plays a regulatory role on inflammatory/anti-inflammatory responses.

Huang, Bor-Ren [Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Taichung Branch, Taichung, Taiwan (China); Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan (China); Tsai, Cheng-Fang [Department of Biotechnology, Asia University, Taichung, Taiwan (China); Lin, Hsiao-Yun [Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan (China); Tseng, Wen-Pei [Graduate Institute of Sports and Health, National Changhua University of Education, Changhua County, Taiwan (China); Huang, Shiang-Suo [Department of Pharmacology and Institute of Medicine, College of Medicine, Chung Shan Medical University, Taiwan (China); Wu, Chi-Rei [Graduate Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, Taiwan (China); Lin, Chingju [Department of Physiology, School of Medicine, China Medical University, Taichung, Taiwan (China); Yeh, Wei-Lan [Cancer Research Center, Department of Medical Research, Changhua Christian Hospital, Changhua, Taiwan (China); Lu, Dah-Yuu, E-mail: dahyuu@mail.cmu.edu.tw [Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan (China)

2013-05-15T23:59:59.000Z

448

Ethanol increases matrix metalloproteinase-12 expression via NADPH oxidase-dependent ROS production in macrophages  

SciTech Connect (OSTI)

Matrix metalloproteinase-12 (MMP-12), an enzyme responsible for degradation of extracellular matrix, plays an important role in the progression of various diseases, including inflammation and fibrosis. Although most of those are pathogenic conditions induced by ethanol ingestion, the effect of ethanol on MMP-12 has not been explored. In the present study, we investigated the effect of ethanol on MMP-12 expression and its potential mechanisms in macrophages. Here, we demonstrated that ethanol treatment increased MMP-12 expression in primary murine peritoneal macrophages and RAW 264.7 macrophages at both mRNA and protein levels. Ethanol treatment also significantly increased the activity of nicotinamide adenine dinucleotide (NADPH) oxidase and the expression of NADPH oxidase-2 (Nox2). Pretreatment with an anti-oxidant (N-acetyl cysteine) or a selective inhibitor of NADPH oxidase (diphenyleneiodonium chloride (DPI)) prevented ethanol-induced MMP-12 expression. Furthermore, knockdown of Nox2 by small interfering RNA (siRNA) prevented ethanol-induced ROS production and MMP-12 expression in RAW 264.7 macrophages, indicating a critical role for Nox2 in ethanol-induced intracellular ROS production and MMP-12 expression in macrophages. We also showed that ethanol-induced Nox2 expression was suppressed by transient transfection with dominant negative I?B-? plasmid or pretreatment with Bay 11-7082, a selective inhibitor of NF-?B, in RAW 264.7 macrophages. In addition, ethanol-induced Nox2 expression was also attenuated by treatment with a selective inhibitor of p38 MAPK, suggesting involvement of p38 MAPK/NF-?B pathway in ethanol-induced Nox2 expression. Taken together, these results demonstrate that ethanol treatment elicited increase in MMP-12 expression via increase in ROS production derived from Nox2 in macrophages. - Highlights: Ethanol increases ROS production through up-regulation of Nox2 in macrophages. Enhanced oxidative stress contributes to ethanol-induced MMP-12 expression. p38 MAPK/NF-?B signaling pathway modulates ethanol-induced Nox2 expression.

Kim, Mi Jin; Nepal, Saroj; Lee, Eung-Seok; Jeong, Tae Cheon [College of Pharmacy, Yeungnam University, Gyeongsanbuk-do 712-749 (Korea, Republic of); Kim, Sang-Hyun [Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422 (Korea, Republic of); Park, Pil-Hoon, E-mail: parkp@yu.ac.kr [College of Pharmacy, Yeungnam University, Gyeongsanbuk-do 712-749 (Korea, Republic of)

2013-11-15T23:59:59.000Z

449

Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells  

SciTech Connect (OSTI)

Chronic arsenic exposure remains a human health risk; however a clear mode of action to understand gene signaling-driven arsenic carcinogenesis is currently lacking. This study chronically exposed human lung epithelial BEAS-2B cells to low-dose arsenic trioxide to elucidate cancer promoting gene signaling networks associated with arsenic-transformed (B-As) cells. Following a 6 month exposure, exposed cells were assessed for enhanced cell proliferation, colony formation, invasion ability and in vivo tumor formation compared to control cell lines. Collected mRNA was subjected to whole genome expression microarray profiling followed by in silico Ingenuity Pathway Analysis (IPA) to identify lung carcinogenesis modes of action. B-As cells displayed significant increases in proliferation, colony formation and invasion ability compared to BEAS-2B cells. B-As injections into nude mice resulted in development of primary and secondary metastatic tumors. Arsenic exposure resulted in widespread up-regulation of genes associated with mitochondrial metabolism and increased reactive oxygen species protection suggesting mitochondrial dysfunction. Carcinogenic initiation via reactive oxygen species and epigenetic mechanisms was further supported by altered DNA repair, histone, and ROS-sensitive signaling. NF-?B, MAPK and NCOR1 signaling disrupted PPAR?/?-mediated lipid homeostasis. A pro-cancer gene signaling network identified increased survival, proliferation, inflammation, metabolism, anti-apoptosis and mobility signaling. IPA-ranked signaling networks identified altered p21, EF1?, Akt, MAPK, and NF-?B signaling networks promoting genetic disorder, altered cell cycle, cancer and changes in nucleic acid and energy metabolism. In conclusion, transformed B-As cells with their whole genome expression profile provide an in vitro arsenic model for future lung cancer signaling research and data for chronic arsenic exposure risk assessment. Highlights: ? Chronic As{sub 2}O{sub 3} exposure to lung epithelial cells resulted in a cancer-like phenotype. ? Mice injected with arsenic transformed (B-As) cells displayed metastatic tumors. ? Microarray profiling revealed changes in mitochondrial metabolism and ROS response. ? p21, EF1?, Akt, MAPK, PPAR? and NF-?B networks promoted pro-cancer signaling. ? B-As cells represent a lung cancer model to explore As-associated carcinogenesis.

Stueckle, Todd A., E-mail: tstueckle@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Lu, Yongju, E-mail: yongju6@hotmail.com [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Davis, Mary E., E-mail: mdavis@wvu.edu [Department of Physiology, West Virginia University, Morgantown, WV 26506 (United States); Wang, Liying, E-mail: lmw6@cdc.gov [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States)] [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Jiang, Bing-Hua, E-mail: bhjiang@jefferson.edu [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States)] [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Holaskova, Ida, E-mail: iholaskova@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Schafer, Rosana, E-mail: rschafer@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Barnett, John B., E-mail: jbarnett@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Rojanasakul, Yon, E-mail: yrojan@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)

2012-06-01T23:59:59.000Z

450

Anti-inflammatory and antifibrotic effects of methyl palmitate  

SciTech Connect (OSTI)

Methyl palmitate (MP) has been shown earlier to inhibit Kupffer cells and rat peritoneal macrophages. To evaluate the potential of MP to inhibit the activation of other macrophages, RAW cells (macrophages of alveolar origin) were treated with varying concentrations of MP (0.25, 0.5, 1 mM). Assessment of cytotoxicity using MTT assay revealed that 0.25 and 0.5 mM are not toxic to RAW cells. MP was able to inhibit the phagocytic function of RAW cells. Treatment of cells with MP 24 hours prior to LPS stimulation significantly decreased nitric oxide release and altered the pattern of cytokines release; there was a significant decrease in TNF-{alpha} and a significant increase in IL-10 compared to the controls. However, there is a non-significant change in IL-6 level. Furthermore, phosphorylation of inhibitory kappa B (I{kappa}B{alpha}) protein was significantly decreased in RAW cells treated with 0.5 mM MP after LPS stimulation. Based upon the in-vitro results, it was examined whether MP treatment will be effective in preventing bleomycin-induced lung inflammation and fibrosis in-vivo. Bleomycin given by itself caused destruction of the lung architecture characterized by pulmonary fibrosis with collapse of air alveoli and emphysematous. Bleomycin induced a significant increase in hydroxyproline level and activated NF-{kappa}B, p65 expression in the lung. MP co-treatment significantly ameliorated bleomycin effects. These results suggest that MP has a potential of inhibiting macrophages in general. The present study demonstrated for the first time that MP has anti-inflammatory and antifibrotic effect that could be through NF-kB inhibition. Thus MP like molecule could be a promising anti-inflammatory and antifibrotic drug. - Research Highlights: >Methyl palmitate is a universal macrophage inhibitor. >It could be a promising nucleus of anti-inflammatory and antifibrotic drugs. >The underlying mechanism of these effects could be through NF-kB inhibition.

El-Demerdash, Ebtehal, E-mail: ebtehal_dm@yahoo.com

2011-08-01T23:59:59.000Z

451

SULFUR HEXAFLUORIDE TREATMENT OF USED NUCLEAR FUEL TO ENHANCE SEPARATIONS  

SciTech Connect (OSTI)

Reactive Gas Recycling (RGR) technology development has been initiated at Savannah River National Laboratory (SRNL), with a stretch-goal to develop a fully dry recycling technology for Used Nuclear Fuel (UNF). This approach is attractive due to the potential of targeted gas-phase treatment steps to reduce footprint and secondary waste volumes associated with separations relying primarily on traditional technologies, so long as the fluorinators employed in the reaction are recycled for use in the reactors or are optimized for conversion of fluorinator reactant. The developed fluorination via SF{sub 6}, similar to the case for other fluorinators such as NF{sub 3}, can be used to address multiple fuel forms and downstream cycles including continued processing for LWR via fluorination or incorporation into a aqueous process (e.g. modified FLUOREX) or for subsequent pyro treatment to be used in advanced gas reactor designs such metal- or gas-cooled reactors. This report details the most recent experimental results on the reaction of SF{sub 6} with various fission product surrogate materials in the form of oxides and metals, including uranium oxides using a high-temperature DTA apparatus capable of temperatures in excess of 1000{deg}C . The experimental results indicate that the majority of the fission products form stable solid fluorides and sulfides, while a subset of the fission products form volatile fluorides such as molybdenum fluoride and niobium fluoride, as predicted thermodynamically. Additional kinetic analysis has been performed on additional fission products. A key result is the verification that SF{sub 6} requires high temperatures for direct fluorination and subsequent volatilization of uranium oxides to UF{sub 6}, and thus is well positioned as a head-end treatment for other separations technologies, such as the volatilization of uranium oxide by NF{sub 3} as reported by colleagues at PNNL, advanced pyrochemical separations or traditional full recycle approaches. Based on current results of the research at SRNL on SF{sub 6} fluoride volatility for UNF separations, SF{sub 6} treatment renders all anticipated volatile fluorides studied to be volatile, and all non-volatile fluorides studied to be non-volatile, with the notable exception of uranium oxides. This offers an excellent opportunity to use this as a head-end separations treatment process because: 1. SF{sub 6} can be used to remove volatile fluorides from a UNF matrix while leaving behind uranium oxides. Therefore an agent such as NF{sub 3} should be able to very cleanly separate a pure UF{sub 6} stream, leaving compounds in the bottoms such as PuF{sub 4}, SrF{sub 2} and CsF after the UNF matrix has been pre-treated with SF{sub 6}. 2. Due to the fact that the uranium oxide is not separated in the volatilization step upon direct contact with SF{sub 6} at moderately high temperatures (? 1000{deg}C), this fluoride approach may be wellsuited for head-end processing for Gen IV reactor designs where the LWR is treated as a fuel stock, and it is not desired to separate the uranium from plutonium, but it is desired to separate many of the volatile fission products. 3. It is likely that removal of the volatile fission products from the uranium oxide should simplify both traditional and next generation pyroprocessing techniques. 4. SF{sub 6} treatment to remove volatile fission products, with or without treatment with additional fluorinators, could be used to simplify the separations of traditional aqueous processes in similar fashion to the FLUOREX process. Further research should be conducted to determine the separations efficiency of a combined SF{sub 6}/NF{sub 3} separations approach which could be used as a stand-alone separations technology or a head-end process.

Gray, J.; Torres, R.; Korinko, P.; Martinez-Rodriguez, M.; Becnel, J.; Garcia-Diaz, B.; Adams, T.

2012-09-25T23:59:59.000Z

452

Response of corn to fertilizer placement on a Hockley fine sandy loam  

E-Print Network [OSTI]

, Texas AikM University. RESPONSE OF CORN TO FERT'lLLZER PLACEMENT ON HOCKLEY FfNE SANDY LOAM I, f N T R OD 'JC T1ON TI . . eff ici. . ncy of farci I i z er i&sage aff. ct'ing th e production of r or n. on medium t extu red roii- in East Texa may..., iiize" i?der conditions i- -i&pi r ior tri o? er rriethod nf appi ication. TI: - opi imi. rn location of the f crt il' zer bi "rl i- rela' 'on to 'I" e you ng p! a "t ma y be a factor affecting fina! p's n' yield. ?. TI. e vigor of' a young seed...

Matocha, John Edward

1964-01-01T23:59:59.000Z

453

Quality and Membrane Treatability of the Lake Houston Water Supply  

E-Print Network [OSTI]

the membrane. This behavior will be employed predominantly to study solute rejection by NF membranes in this report. Page 7 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 0.5 0.6 0.7 0.8 0.9 1.0 10 15 20 25 30 35 40 45 Contamin ant rejection (-) Permeate flux (L/m..., Dionex Corporation, Sunnyvale, CA) comprising of a guard column, analytical column (Dionex AG9-HC), suppressor device, and a conductivity detector (Dionex CD 20). Eluent used was 9.0 mM Na 2 CO 3 . A typical calibration curve obtained for chloride ion...

Chellam, Shankar; Sharma, Ramesh; Shetty, Grishma; Wei, Ying

2001-10-01T23:59:59.000Z

454

Injection/Extraction Studies for the Muon FFAG  

SciTech Connect (OSTI)

The non-scaling fixed field alternating gradient (NS-FFAG) ring is a candidate muon accelerator in the Neutrino Factory complex according to the present baseline, which is currently being addressed by the International Design Study (IDS-NF). In order to achieve small orbit excursion, motivated by magnet cost reduction, and small time of flight variation, dictated by the need to use high RF frequency, lattices with a very compact cell structure and short straight sections are required. The resulting geometry dictates very difficult constraints on the injection/extraction systems. Beam dynamics in the non-scaling FFAG is studied using codes capable of correctly tracking with large transverse amplitude and momentum spread. The feasibility of injection/extraction is studied and various implementations focusing on minimization of kicker/septum strength are presented. Finally the parameters of the resulting kicker magnets are estimated.

Pasternak, J. [Imperial College London, Department of Physics, London (United Kingdom); STFC/RAL/ISIS, Chilton, Didcot, Oxon (United Kingdom); Aslaninejad, M. [Imperial College London, Department of Physics, London (United Kingdom); Berg, J. Scott [BNL, Upton, Long Island, New York (United States); Kelliher, D. J.; Machida, S. [STFC/ASTeC/RAL, Chilton, Didcot, Oxon (United Kingdom)

2010-03-30T23:59:59.000Z

455

The $D_s$, $D^+$, $B_s$ and $B$ decay constants from $2+1$ flavor lattice QCD  

E-Print Network [OSTI]

We present a study of the $D$ and $B$ leptonic decay constants on the MILC $N_f=2+1$ asqtad gauge ensembles using asqtad-improved staggered light quarks and clover heavy quarks in the Fermilab interpretation. Our previous analysis \\cite{Bazavov:2011aa} computed the decay constants at lattice spacings $a \\approx 0.14, 0.11$ and $0.083$ fm. We have extended the simulations to finer $a \\approx 0.058$ and $0.043$ fm lattice spacings, and have also increased statistics; this allows us to address many important sources of uncertainty. Technical advances include a two-step two-point fit procedure, better tuning of the heavy quark masses and a better determination of the axial-vector current matching. The present analysis remains blinded, so here we focus on the improvements and their predicted impact on the error budget compared to the prior analysis.

A. Bazavov; C. Bernard; C. Bouchard; C. DeTar; D. Du; A. X. El-Khadra; J. Foley; E. D. Freeland; E. Gmiz; Steven Gottlieb; U. M. Heller; J. Kim; J. Komijani; A. S. Kronfeld; J. Laiho; L. Levkova; P. B. Mackenzie; D. Mohler; E. T. Neil; M. B. Oktay; S. Qiu; J. N. Simone; R. L. Sugar; D. Toussaint; R. S. Van de Water; R. Zhou

2014-03-27T23:59:59.000Z

456

Dissipative Cryogenic Filters with Zero DC Resistance  

SciTech Connect (OSTI)

The authors designed, implemented and tested cryogenic RF filters with zero DC resistance, based on wires with a superconducting core inside a resistive sheath. The superconducting core allows low frequency currents to pass with negligible dissipation. Signals above the cutoff frequency are dissipated in the resistive part due to their small skin depth. The filters consist of twisted wire pairs shielded with copper tape. Above approximately 1 GHz, the attenuation is exponential in {radical}{omega}, as typical for skin depth based RF filters. By using additional capacitors of 10 nF per line, an attenuation of at least 45 dB above 10 MHz can be obtained. Thus, one single filter stage kept at mixing chamber temperature in a dilution refrigerator is sufficient to attenuate room temperature black body radiation to levels corresponding to 10 mK above about 10 MHz.

Bluhm, Hendrik; Moler, Kathryn A.; /Stanford U., Appl. Phys. Dept

2008-04-22T23:59:59.000Z

457

Nano-structure multilayer technology fabrication of high energy density capacitors for the power electronic building book  

SciTech Connect (OSTI)

Commercially available capacitors do not meet the specifications of the Power Electronic Building Block (PEBB) concept. We have applied our propriety nanostructure multilayer materials technology to the fabrication of high density capacitors designed to remove this impediment to PEBB progress. Our nanostructure multilayer capacitors will also be enabling technology in many industrial and military applications. Examples include transient suppression (snubber capacitors), resonant circuits, and DC filtering in PEBB modules. Additionally, weapon applications require compact energy storage for detonators and pulsed-power systems. Commercial applications run the gamut from computers to lighting to communications. Steady progress over the last five years has brought us to the threshold of commercial manufacturability. We have demonstrated a working dielectric energy density of > 11 J/cm3 in 20 nF devices designed for 1 kV operation.

Barbee, T.W.; Johnson, G.W.; Wagner, A.V.

1997-10-21T23:59:59.000Z

458

Nepali Aawaz Volume 1, Issue 14, 10 May 2006  

E-Print Network [OSTI]

Qm ^) xhf/ lnP/ k7fPsf df]/sf oL tLg hgf b'O{ dlxgfb]lv stf/df cnkq k/]sf x'g\\ . pgLx?nfO{ vfg / a:g ;d]t sl7g ePsf] 5 . United we stand snfsf/x?sf] lab]z df]x 1974 AD: On Air bnfnn] em'SofP/ stf/df g]kfnL cnkq 21 #25; Nepali Aawaz... achieved something through this revolution. - Prem#25;Shrestha, Abukhaireni, Tanahun, in a letter to the editor of Kantipur. ut d+l;/ & ut] ;ft /fhg}lts bn tyf xfd|f] kf6L{aLr ;DkGg !@a'Fb] P]ltxfl;s ;dembf/Lk|lt k"0f{ k|lta4 x'Fb} ;+ljwfg...

Shrestha, Kashish Das

459

Temperature control of some metallic conductors in the region of the melting point  

E-Print Network [OSTI]

. A. C. Power Amplifier and Demodulator Figure 14 shows the A. C. power amplifier and the demodulator stage of the control system. 150 V. D. C. 150 U. D. C. 15K 40MF 20NF 5K 6V6 6SN7 220 ohms 45v 1K Pot . 470 ohms 7 II Figure 14 The 6V6... is shown in Figure 19. 0. 25 to 1 MF 2 OK Pot. 3 100K 1 M 1 MP 68K 1 M 100K Chopper ] I I I I I I I I I I I I ?? I I I I I I I I 9 I r I I I I I I I I I I 2. 2 M 7 I -30 volts 2' 3' 40 MF 20 MF 6V6 24MF 220...

Rahman, Arifur

1961-01-01T23:59:59.000Z

460

A small unperturbing probe for the measurement and mapping of electric fields at extremely low frequencies  

E-Print Network [OSTI]

rom LP2 ) R3 300kII nA 741 3 6 + Al 2 4 LS600 o Axis elector I Prom . . LP1 I I I I I I I I I Ql MEM55 4C Rl CA Cl 82 pF I R2 100 k 0 I I I I I R4 1MC I I I I I ~Electrostatic shield C3 ~ 7 IJ R5 20MD C2... to Integrators R33 1M0 R30 340 RA 7 nA741 3 6 + A4 2 LED1 FLV110 Q] 9 LS600 Q20 LS600 From LP3 9. 8V To 22 R29 200 kg R32 1MG R31 340k 0 R34 1k 0 010 5 nF Q21 MPS6555 Fig. 17 . Axis selector, optoelectronic converter and hattery switching...

Shrekenhamer, Abraham

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

100 Area D4 Project Building Completion Report - July 2007 to December 2008  

SciTech Connect (OSTI)

This report documents the decontamination, decommissioning, and demolition of the 105-NB, 163-N, 183-N, 183-NA, 183-NB, 183-NC, 184-N, 184-NA, 184-NB, 184-NC, 184-ND, 184-NE, 184-NF, 1312-N, 1330-N, 1705-N, 1705-NA, 1706-N, 1712-N, 1714-N, 1714-NA, 1714-NB, 1802-N, MO-050, MO-055, MO-358, MO-390, MO-900, MO-911, and MO-950 facilities in the 100 Area of the Hanford Site. The D4 activities for these facilities include utility disconnection, planning, characterization, engineering, removal of hazardous and radiological contaminated materials, equipment removal, decommissioning, deactivation, decontamination, demolition of the structure, and removal of the remaining slabs.

M. T. Stankovich

2009-04-15T23:59:59.000Z

462

Computer determination of bacterial volume  

E-Print Network [OSTI]

~, ~ Computer A1". . v', tI'i. : 22 vz: LIST OP TABLES Table I. liean Cellular Volur" ~ nf:-63 i it". , easur ed usinr; Tji!0 (0+ i. u-'tj -o3a, Y e J An- lyzer Ta31e II, &'!ean Cellular Volu", . e of E-6ig Yieasured Uslnq TN 1705 ". 'i. ulti...CCNPU. "ZE D"1 '6 ~'1. '~A""1 iu'i iY EACTEl'. JAi V 'LUV, E 'l'he s i e HAUTE' *8, LIAY. QRJEEES SabFi i te(i 0 'l'ne Gx ala%'6?' c11 ege cf exas A%5: Universi+; pal' t la 1 f a 1 f 1 1 Pen 'h Qf 4' t1 e, '. e ll 'J 3 n e~ en' f ox' 't l i 6...

Griffis, David William

2012-06-07T23:59:59.000Z

463

A study of a small supersonic wind tunnel  

E-Print Network [OSTI]

!alla of optic . 1 plass& ps!i!It tho viev!1?y. o3. ' th. floe. !Ire te' t si-d&xls are s r fr!g slif&po Led fr'~N1 a sector' rrhi h p!vota stout a vir'tti'&1 cen, cx' 3/1/& 3:1"h d!&s&str" ". of t!s n!xz3&: e". 'b plane? !h&e iu'". e of Gtiacic pos3 I, IC... ". rnn Tn, . 3!l&~, 'l. f'i'! il35--l l'Jy I&'3. -"l '. ~ F(:rn'. . ! A 1, 3': '. ! . ?C! uf . "':. !no~3)'!'!. =? ~os of. So)o::. -!onlo F1o!":! '. '. . ':!113:;o Co;!2~nf. 3. ~). lg, , ', &, 'ni"C?, il 'ln:s &o. '!. ' "o ! 'l (! if 3'3on' 1 on...

Chang, Pu-Kwang

2012-06-07T23:59:59.000Z

464

Economics of Citrus Production in the Rio Grande Valley.  

E-Print Network [OSTI]

C H t NF. F: Y TRACTOR S IPRIGATION MACHINE~Y TAXES(L~NO. WATl~) PRO~ATEU F S TAH. COST LA NO (NET P E NT' TOTAL FIXfD COSTS 5. TOTAL COSTS h. NET RE TURNS TON ACRE ACRE APPL A CR f" APPL AC q f: AC~E ACR f" ACR E ACQE HOUR HOUP....31 1.37 1. 37 0.07 1.37 0.01 I.J7 0.79 1 .40 1.37 1.40 0.52 1. 37 1.40 1. 37 0.52 _1 .. J1 0.61 '.) ? ~ 1 C~OP SOLD eN TRFES. PRORATED ESTABLI5H~rNT COST INCLUDES ALLOWAN FOP DEPRECI~TION AND INTERF5T ON G~OVE OEV~LOPMF~T. PREPARED...

Reichardt, Alan W.

1977-01-01T23:59:59.000Z

465

Electrostatic potential variation on the flux surface and its impact on impurity transport  

E-Print Network [OSTI]

The particle transport of impurities in magnetically confined plasmas under some conditions does not find, neither quantitatively nor qualitatively, a satisfactory theory-based explanation. This compromise the successful realization of thermo-nuclear fusion for energy production since its accumulation is known to be one of the causes that leads to the plasma breakdown. In standard reactor-relevant conditions this accumulation is in most stellarators intrinsic to the lack of toroidal symmetry, that leads to the neoclassical electric field to point radially inwards. This statement, that the standard theory allows to formulate, has been contradicted by some experiments that showed weaker or no accumulation under such conditions \\cite{Ida_pop_16_056111_2009, Yoshinuma_nf_49_062002_2009}. The charge state of the impurities makes its transport more sensitive to the electric fields. Thus, the short length scale turbulent electrostatic potential or its long wave-length variation on the flux surface $\\Phi_{1}$ -- that...

Garca-Regaa, J M; Turkin, Y; Kleiber, R; Helander, P; Maaberg, H; Alonso, J A; Velasco, J L

2015-01-01T23:59:59.000Z

466

Nuclear forces in the parity odd sector and the LS forces  

E-Print Network [OSTI]

In this paper, we report our first attempt at determining NN potentials in the parity odd sector including the spin-orbit force in lattice QCD, employing the method to extract successfully parity even NN potentials from Nambu-Bethe-Salpeter (NBS) wave functions through the Schr\\"odinger equation. Using Nf = 2 CP-PACS gauge configurations on a 16^3 x 32 lattice at a = 0.16 fm and m_\\pi \\cong 1.1 GeV, we calculate central, tensor and spin-orbit potentials in the parity odd sector. Although statistical errors are still large, we observe that the qualitative features of these potentials roughly agree with those of phenomenological potentials.

Keiko Murano; for the HALQCD Collaboration

2011-12-09T23:59:59.000Z

467

Blau Syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and Helical Domain 1 as signalling regulators  

E-Print Network [OSTI]

underthecontrolofanNF?Bpromoterand160 phrG encodingRenillaluciferasecontrolledbyaconstitutivepromoterwerekindgiftsfromProf161 ClareBryant.162 N F k B reporterassays163 HEK293T cellsin96 wellplatesweretransfectedwith:2ngpLuc,1ngphrG, 0.1ng... MayleforassistancewithreporterassaysandProfClareBryantfor201 helpfuldiscussionandguidance.ThisworkwasfundedbyaWellcome TrustCDF(WT085090MA )to202 TPM.203 204 References 205 1 Miceli?Richard,C.etal.(2001)CARD...

Parkhouse, Rhiannon; Boyle, Joseph P.; Monie, Tom P.

2014-08-02T23:59:59.000Z

468

A refined deflected gradient search program for solving nonlinear maximization problems  

E-Print Network [OSTI]

;. , ';)+5 rjj t'rcd, qosenbr(ck'5 method, I atl urn sr!avch, poj)el1'5 t le!hod dnd IC!)to!1 sr'at c(1. Tn) 5 i 5 y !'0 jeans 2 cr ivp'I el 2 I i ": c)r)g 0 5 5 '2! Oh !)!ol liods. r 5( h nf the ( 00'rc ji" . '10ds !? , '1 l)e (, . c! '. , 5! d briefly... h(! dcf! -'ctc'&1 grad i- nt 1 s scj ca11ed becau ' j'. he &Ji', ection of ', . "ch a'; Cije !I s!. eo is ai jng th!- vector li I f, ath! r n Ij ale! I:he qr:diont vec+o! j&f: . Fhe search alo&jg ih t ucc I n gefo!: exajjining ho!a tnc sequence...

Clark, Raymond Earl

2012-06-07T23:59:59.000Z

469

Growth and development of the tomato under high summer light intensities and high temperatures  

E-Print Network [OSTI]

of the tomato plant have been made by Kraus and Kraybill (20), Nightingale (28), Foster and Tatman (7) and 6 others. These workers found that low temperatures, low soil moisture, and low nitrogen favor accumulation of starch in the tomato plant. 7 A brief... April May June July Mig Sept Oct y*.1 jG11 G1 WlmmNHL Dc mDEAbsL ATmCTHNAlHTW OE iThHTTW yNbHTEbTOA NA aDssThT PANAODEg JTfNW1 FCCTH sOETW WbDu iOlHENs mNfOmlm ATmCTHNAlHTWg sDuTH sOETW AbT EDeAlHENs mOEOmlm ATmCTHNY AlHTW1 FCCTH iNWbTi sOET OEi...

Johnson, Samuel Park

1954-01-01T23:59:59.000Z

470

A Feynman-Hellmann approach to the spin structure of hadrons  

E-Print Network [OSTI]

We perform a Nf = 2 + 1 lattice QCD simulation to determine the quark spin fractions of hadrons using the Feynman-Hellmann theorem. By introducing an external spin operator to the fermion action, the matrix elements relevant for quark spin fractions are extracted from the linear response of the hadron energies. Simulations indicate that the Feynman-Hellmann method offers statistical precision that is comparable to the standard three-point function approach, with the added benefit that it is less susceptible to excited state contamination. This suggests that the Feynman-Hellmann technique offers a promising alternative for calculations of quark line disconnected contributions to hadronic matrix elements. At the SU(3)-flavour symmetry point, we find that the connected quark spin fractions are universally in the range 55-70% for vector mesons and octet and decuplet baryons. There is an indication that the amount of spin suppression is quite sensitive to the strength of SU(3) breaking.

A. J. Chambers; R. Horsley; Y. Nakamura; H. Perlt; D. Pleiter; P. E. L. Rakow; G. Schierholz; A. Schiller; H. Stben; R. D. Young; J. M. Zanotti

2014-05-13T23:59:59.000Z

471

A quantitative comparison of An-56477, trifluralin and nitralin losses from soil  

E-Print Network [OSTI]

. jr 1 w~i:, zw ?- of tuf'kj;?saridy los!s soi! ri!, r. . :do . r. e:: -' . i! sar?o?s ! ou''3'i i! ':! ' d c, . !iso! '' ~ Ti!e dish" sir s 1!e. . . , s ' d !ai . h ej th'- . ", n-~6, ;"( ti-j f3!!ra! j n or?itrslin at o retxi of ! r?ort & r... 'hg e 3. n t 3 g". l os 'r*'eter to e 1't. ":3n end/ jiinni =; f l! eni Bt!elect . , w, e pef 'Po 1!;Q, iZ+ c r f C) hr expoen 'c to . ri" 'i, '. ':it on, 'i a fc=xlfc!:. ~ '~effncret, nf o oT 35 i', 1 F. 'cld Ce:. . ;ity g Remi n5n, ; ?t...

Behan, Dale Eugene

1971-01-01T23:59:59.000Z

472

The World of Dark Shadows Issue 14  

E-Print Network [OSTI]

-Liltz and Li nd a d oo js. Friday, ,;ept embcr 50Th !' con v'Jllt ion officially began a t 1: 00. Barb , ~eC;GY .~ ree n ~ l1d ~ h :d iJ L 'ead y spe n t the mornin u setting up the ex hibi t roolD, we were waitinG in l i n e to b e regi ste red , while... !:J:lA D0'". :;()' .t:be WORLDoFMRK StUlOOWS it: I :., o~e n a w... il~ ";1 .':", -::''] :':; :} U l.C :JIl ( :': I .~ t !t wfJ ek '?nri ., ' ?b 'Nf1 ~n t in :r'H; .\\ j enTtigr:liTI l'u ., ll cn d or;. Ei muTiti:l.O-l\\aiz lntJ/ IJr 101...

Multiple Contributors

1977-01-01T23:59:59.000Z

473

IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein  

SciTech Connect (OSTI)

The existence of transcripts that span two adjacent, independent genes is considered rare in the human genome. This study characterizes a novel human fusion gene named IQCJ-SCHIP1. IQCJ-SCHIP1 is the longest isoform of a complex transcriptional unit that bridges two separate genes that encode distinct proteins, IQCJ, a novel IQ motif containing protein and SCHIP1, a schwannomin interacting protein that has been previously shown to interact with the Neurofibromatosis type 2 (NF2) protein. IQCJ-SCHIP1 is located on the chromosome 3q25 and comprises a 1692-bp transcript encompassing 11 exons spanning 828 kb of the genomic DNA. We show that IQCJ-SCHIP1 mRNA is highly expressed in the brain. Protein encoded by the IQCJ-SCHIP1 gene was localized to cytoplasm and actin-rich regions and in differentiated PC12 cells was also seen in neurite extensions.

Kwasnicka-Crawford, Dorota A. [Department of Genetics and Genomic Biology, Hospital for Sick Children, Toronto, Ont. (Canada) and Department of Kinesiology and Health Science, Faculty of Health, York University, 346 Norman Bethune College, 4700 Keele Street, Ont., Canada M3J-1P3 (Canada)]. E-mail: dakc@yorku.ca; Carson, Andrew R. [Department of Genetics and Genomic Biology, Hospital for Sick Children, Toronto, Ont. (Canada); Scherer, Stephen W. [Department of Genetics and Genomic Biology, Hospital for Sick Children, Toronto, Ont. (Canada); Department of Molecular and Medical Genetics, University of Toronto, Ont. (Canada)

2006-12-01T23:59:59.000Z

474

Method for studying a sample of material using a heavy ion induced mass spectrometer source  

DOE Patents [OSTI]

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high n,f reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu.

Fries, David P. (St. Petersburg, FL); Browning, James F. (Palm Harbour, FL)

1999-01-01T23:59:59.000Z

475

Nepali Aawaz Volume 1, Issue 11, 8 March 2006  

E-Print Network [OSTI]

FOR DETAILS AND IMMEDIATE WORK OPPORTUNITIES: 136- 89 ROOSEVELT AVE. #303, FLUSHING, NY 11354 PHONE: 718- 762- 4001 7Nepali Aawaz | Falgun 25.2062 Politics 6f9f /x]sfn] cfGbf]ngn] lng' kg]{ htL ultL lng g;s]sf] o'jf g]tf uug yfkf atfp5g . k|:t't 5, nf]s tfl... Gg] sfdgf ug'{ Aoy{ x'G5 . pgLx?sf] s'/f ;'Gg' k5{ / xfd|f] s'/f a'fpg'k5{ . clxn] eO{/x]sf] cfGbf]ng klg o'jfx?n] g} l6sfO{ /x]sf5g, c of] lgl:qmo ;d'xnfO{ ;lqmo kfg]{ xf] eg] s:tf] utL lnG5 lnG5 . clxn] klg cf...

Shrestha, Kashish Das

476

A microbiological examination of deep muscle tissue of beef, pork and lamb carcasses  

E-Print Network [OSTI]

. 27: 101-119 ' 12. 0' fco, 1 63. 0' fco !) annal. 9! h od. 0$(fr n limbers for)i I s p Inc . , De' r &it, iiichig' n Gf '- 0 -cn. . =-':. 'e i lr)r;, ! 2nd d. 9 "o, ss !)ilb11 sh- ing Co, ' inn; )poli s~ iiinn. i car) ~ r N C, 1967, i c& . d !!I crn... solates b Coagulase -posit)&ro staphylococci. c Coa&g?lese -&&&n&gative s t;, &phy) ococci. pot &&&oe (, 5'de was used for other purposes before sample could be taken. ) 47 Table l 9. Typn s &nf nil&. roe& geo 1 snis is&. l d Led n icer oh r...

Nickelson, Ranzell, II

1969-01-01T23:59:59.000Z

477

Short Range Correlations and the EMC Effect  

SciTech Connect (OSTI)

This Letter shows quantitatively that the magnitude of the EMC effect measured in electron deep inelastic scattering at intermediate xB, 0.35?xB?0.7, is linearly related to the short range correlation (SRC) scale factor obtained from electron inclusive scattering at xB?1. The observed phenomenological relationship is used to extract the ratio of the deuteron to the free pn pair cross sections and F2n/F2p, the ratio of the free neutron to free proton structure functions. We speculate that the observed correlation is because both the EMC effect and SRC are dominated by the high virtuality (high momentum) nucleons in the nucleus.

L.B. Weinstein, E. Piasetzky, D.W. Higinbotham, J. Gomez, O. Hen, R. Shneor

2011-02-01T23:59:59.000Z

478

Short Range Correlations and the EMC Effect  

E-Print Network [OSTI]

This paper shows quantitatively that the magnitude of the EMC effect measured in electron deep inelastic scattering (DIS) at intermediate $x_B$, $0.35\\le x_B\\le 0.7$, is linearly related to the Short Range Correlation (SRC) scaling factor obtained from electron inclusive scattering at $x_B\\ge 1.$. The observed phenomenological relationship is used to extract the ratio of the deuteron to the free $pn$ pair cross sections, the DIS cross section for a free neutron, and $F_2^n/F_2^p$, the ratio of the free neutron to free proton structure functions. We speculate that the observed correlation is because both the EMC effect and SRC are dominated by the high virtuality (high momentum) nucleons in the nucleus.

L. B. Weinstein; E. Piasetzky; D. W. Higinbotham; J. Gomez; O. Hen; R. Shneor

2011-01-18T23:59:59.000Z

479

The Polyakov loop and the hadron resonance gas model  

E-Print Network [OSTI]

The Polyakov loop has been used repeatedly as an order parameter in the deconfinement phase transition in QCD. We argue that, in the confined phase, its expectation value can be represented in terms of hadronic states, similarly to the hadron resonance gas model for the pressure. Specifically, L(T) \\approx 1/2\\sum_\\alpha g_\\alpha \\,e^(-\\Delta_\\alpha/T), where g_\\alpha are the degeneracies and \\Delta_\\alpha are the masses of hadrons with exactly one heavy quark (the mass of the heavy quark itself being subtracted). We show that this approximate sum rule gives a fair description of available lattice data with N_f=2+1 for temperatures in the range 150MeVmodels. For temperatures below 150MeV different lattice results disagree. One set of data can be described if exotic hadrons are present in the QCD spectrum while other sets do not require such states.

E. Megias; E. Ruiz Arriola; L. L. Salcedo

2012-04-11T23:59:59.000Z

480

Superconducting Cosmic Strings and One Dimensional Extended Supersymmetric Algebras  

E-Print Network [OSTI]

In this article we study in detail the supersymmetric structures that underlie the system of fermionic zero modes around a superconducting cosmic string. Particularly, we extend the analysis existing in the literature on the one dimensional $N=2$ supersymmetry and we find multiple $N=2$, $d=1$ supersymmetries. In addition, compact perturbations of the Witten index of the system are performed and we find to which physical situations these perturbations correspond. More importantly, we demonstrate that there exists a much more rich supersymmetric structure underlying the system of fermions with $N_f$ flavors and these are $N$-extended supersymmetric structures with non-trivial topological charges, with "$N$" depending on the fermion flavors.

V. K. Oikonomou

2014-04-30T23:59:59.000Z

Note: This page contains sample records for the topic "toiyabe nf lessee" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Precision neutron interferometric measurement of the nd coherent neutron scattering length and consequences for models of three-nucleon forces  

E-Print Network [OSTI]

We have performed the first high precision measurement of the coherent neutron scattering length of deuterium in a pure sample using neutron interferometry. We find b_nd = (6.665 +/- 0.004) fm in agreement with the world average of previous measurements using different techniques, b_nd = (6.6730 +/- 0.0045) fm. We compare the new world average for the nd coherent scattering length b_nd = (6.669 +/- 0.003) fm to calculations of the doublet and quartet scattering lengths from several modern nucleon-nucleon potential models with three-nucleon force (3NF) additions and show that almost all theories are in serious disagreement with experiment. This comparison is a more stringent test of the models than past comparisons with the less precisely-determined nuclear doublet scattering length of a_nd = (0.65 +/- 0.04) fm.

T. C. Black; P. R. Huffman; D. L. Jacobson; W. M. Snow; K. Schoen; M. Arif; H. Kaiser; S. K. Lamoreaux; S. A. Werner

2003-05-21T23:59:59.000Z

482

An acoustic numerical analysis of single rotation torpedo propeller  

E-Print Network [OSTI]

&vers&ty C'hatrman of Adv&sorv C'ummittee Dr Kenneth D Ivnrkan 5 numerical study of the acoust&c field asscsciated ivith a t?rped& pr &!&cll&-r hav&ng fnur blades i&as accomplished thr&?&gh the application nf Su& ci method The Succi acnustic analvsi ivas m... I-d&g&t se?es air!'n&1 data ba. e to calculate the lift and &&rag f ir each blade segment, These values vere then converted ti thrust and torque radial distr&butinns. Alsn a rav tracing techniq?e ivas inc&tip&i&at&. c! int& tlic Succi numencal...

Kim, Soo Yong

1989-01-01T23:59:59.000Z

483

River System Hydrology in Texas  

E-Print Network [OSTI]

,700 86,700 Proctor Leon River USACE 1963 59,400 54,702 310,100 Belton Leon River USACE 1954 457,600 432,978 640,000 Stillhouse Hollow Lampasas River USACE 1968 235,700 224,279 390,660 Georgetown San Gabriel R USACE 1980 37,100 36,980 87,600 Granger... San Gabriel R USACE 1980 65,500 50,540 162,200 Somerville Yequa Creek USACE 1967 160,110 154,254 337,700 Hubbard Creek Hubbard Creek WCTMWD 1962 317,750 317,750 Post NF Double Mt WRMWD proposed 57,420 Alan Henry SF Double Mt Lubbock 1993 115...

Wurbs, R.; Zhang, Y.

2014-01-01T23:59:59.000Z

484

Measurement of the neutron F2 structure function via spectator tagging with CLAS  

DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

We report on the first measurement of the F2 structure function of the neutron from semi-inclusive scattering of electrons from deuterium, with low-momentum protons detected in the backward hemisphere. Restricting the momentum of the spectator protons to ? 100 degrees relative to the momentum transfer allows an interpretation of the process in terms of scattering from nearly on-shell neutrons. The F2n data collected cover the nucleon resonance and deep-inelastic regions over a wide range of x for 0.65 2 2, with uncertainties from nuclear corrections estimated to be less than a few percent. These measurements provide the first determination of the neutron to proton structure function ratio F2n/F2p at 0.2 ?< x ?< 0.8, essentially free of nuclear corrections.

Baillie, N; Zhang, J; Bosted, P; Bultmann, S; Christy, M E; Fenker, H; Griffioen, K A; Keppel, C E; Kuhn, S E; Melnitchouk, W; Tvaskis, V; Adhikari, K P; Adikaram, D; Aghasyan, M; Amaryan, M J; Anghinolfini, M; Arrington, J; Avakian, H; Baghdasaryan, H; Battaglieri, M; Biselli, A A; Branford, D; Briscoe, W J; Brooks, W K; Burkert, V D; Carman, D S; Celentano, A; Chandavar, S; Charles, G; Cole, P L; Contalbrigo, M; Crede, V; D' Angelo, A; Daniel, A; Dashyan, N; De Vita, R; De Sanctis, E; Deur, A; Dey, B; Djalali, C; Dodge, G; Domingo, J; Doughty, D; Dupre, R; Dutta, D; Ent, R; Egiyan, H; El Alaoui, A; El Fassi, L; Elouadrhiri, L; Eugenio, P; Fedotov, G; Fegan, S; Fradi, A; Gabrielyan, M Y; Gevorgyan, N; Gilfoyle, G P; Giovanetti, K L; Girod, F X; Gohn, W; Golovatch, E; Gothe, R W; Graham, L; Guegan, B; Guidal, M; Guler, N; Guo, L; Hafidi, K; Heddle, D; Hicks, K; Holtrop, M; Hungerford, E; Hyde, C E; Ilieva, Y; Ireland, D G; Ispiryan, M; Isupov, E L; Jawalkar, S S; Jo, H S; Kalantarians, N; Khandaker, M; Khetarpal, P; Kim, A; Kim, W; King, P M; Klein, A; Klein, F J; Klimenko, A; Kubarovsky, V; Kuleshov, S V; Kvaltine, N D; Livingston, K; Lu, H Y; MacGregor, I.J. D; Mao, Y; Markov, N; McKinnon, B; Mineeva, T; Morrison, B; Moutarde, H; Munevar, E; Nadel-Turonski, P; Ni, A; Niccolai, S; Niculescu, I; Niculescu, G; Osipenko, M; Ostrovidov, A I; Pappalardo, L; Park, K; Park, S; Pasyuk, E; Anefalos Pereira, S; Pisano, S; Pozdniakov, S; Price, J W; Procureur, S; Prok, Y; Protopopescu, D; Raue, B A; Ricco, G; Rimal, D; Ripani, M; Rosner, G; Rossi, P; Sabatie, F; Saini, M S; Salgado, C; Schott, D; Schumacher, R A; Seder, E; Sharabian, Y G; Sober, D I; Sokhan, D; Stepanyan, S; Stepanyan, S S; Stoler, P; Strauch, S; Taiuti, M; Tang, W; Ungaro, M; Vineyard, M F; Voutier, E; Watts, D P; Weinstein, L B; Weygand, D P; Wood, M H; Zana, L

2012-04-06T23:59:59.000Z

485

The development of a rod-coil redox polymer composed of biphenyl esters and poly (4-vinylpyridine)  

E-Print Network [OSTI]

such as dichloromethane. Cleavage of the protecting group is usually accomplished by acids or by a fluoride ion (Bu4N'F, KF or aqueous HF in CHsCN). Base Me)Sicl + ~ SM [Hct 0 R H I es 3. 2. 2. 1 Reagents. Ether, 4-hydroxy-4-biphenyl carboxylic acid, petroleum ether... CHs CH3 CHs I C ? OH + HO y y y y C ? 0 ? Si ? C ? CH CHs CHs 0 0 CHs CH3 CHs II I I C ? 0 y g y y C ? 0 ? SI ? C ? CH CHs CHs DiPC DPTS Figure 3-3. The chemical reaction of room temperature esterification. The coil, with the carboxylic...

DeCormier, Amy Urbanowicz

2012-06-07T23:59:59.000Z

486

Newer method for analyzing naphthenic acids in petroleum  

SciTech Connect (OSTI)

The naphthenic acids in petroleum are considered a class of biological markers. Their potential use in source correlation and as indicator of biodegradation have been reported in the past. Their presence in waste water at refineries may also cause corrosion problems and fish toxicity. Due to their highly complicated nature, detailed characterization of the acids has been difficult and time consuming. This talk will describe a relatively simple approach in characterizing the acids based on their group types. The acids were first separated from petroleum followed by mass spectrometric determinations. Two newer methods were developed to analyze the acid components, namely Chemical Ionization with NF{sub 3} as reagent gas and negative ion Fast Atom Bombardment. The geochemical interpretation based on acid distribution will be demonstrated with a set of well understood crude oil samples.

Fan, T.P. (Shell Development Co., Houston, TX (United States))

1990-08-01T23:59:59.000Z

487

Cantor sets and their relation to upper semi-continuous collections  

E-Print Network [OSTI]

~tl Df' ttt 2. 2. 1. Gt d p ttt felt 1 p * X if G is a collection of subsets of X such that each point of X belongs to one and only one set of G. D ft ltl 2. 2. 2. G 1 nf * 1- tt ~d'tt of a topological space X if G is a decomposition of X and if gtG... and g&U open in X, then there exists V open in X such that gt V CU and if htG and h AV$42 then hCU. Throughout this paper we let f be a continuous function from the Cantor set C onto a T space X. Whyburn $8] proved if we let G 2 -1 (f (x): xt...

Granberry, Verland Lee

1977-01-01T23:59:59.000Z

488

Use of Treated Municipal Wastewater as Power Plant Cooling System Makeup Water: Tertiary Treatment versus Expanded Chemical Regimen for Recirculating Water Quality Management  

SciTech Connect (OSTI)

Treated municipal wastewater is a common, widely available alternative source of cooling water for thermoelectric power plants across the U.S. However, the biodegradable organic matter, ammonia-nitrogen, carbonate and phosphates in the treated wastewater pose challenges with respect to enhanced biofouling, corrosion, and scaling, respectively. The overall objective of this study was to evaluate the benefits and life cycle costs of implementing tertiary treatment of secondary treated municipal wastewater prior to use in recirculating cooling systems. The study comprised bench- and pilot-scale experimental studies with three different tertiary treated municipal wastewaters, and life cycle costing and environmental analyses of various tertiary treatment schemes. Sustainability factors and metrics for reuse of treated wastewater in power plant cooling systems were also evaluated. The three tertiary treated wastewaters studied were: secondary treated municipal wastewater subjected to acid addition for pH control (MWW_pH); secondary treated municipal wastewater subjected to nitrification and sand filtration (MWW_NF); and secondary treated municipal wastewater subjected nitrification, sand filtration, and GAC adsorption (MWW_NFG). Tertiary treatment was determined to be essential to achieve appropriate corrosion, scaling, and biofouling control for use of secondary treated municipal wastewater in power plant cooling systems. The ability to control scaling, in particular, was found to be significantly enhanced with tertiary treated wastewater compared to secondary treated wastewater. MWW_pH treated water (adjustment to pH 7.8) was effective in reducing scale formation, but increased corrosion and the amount of biocide required to achieve appropriate biofouling control. Corrosion could be adequately controlled with tolytriazole addition (4-5 ppm TTA), however, which was the case for all of the tertiary treated waters. For MWW_NF treated water, the removal of ammonia by nitrification helped to reduce the corrosivity and biocide demand. Also, the lower pH and alkalinity resulting from nitrification reduced the scaling to an acceptable level, without the addition of anti-scalant chemicals. Additional GAC adsorption treatment, MWW_NFG, yielded no net benefit. Removal of organic matter resulted in pitting corrosion in copper and cupronickel alloys. Negligible improvement was observed in scaling control and biofouling control. For all of the tertiary treatments, biofouling control was achievable, and most effectively with pre-formed monochloramine (2-3 ppm) in comparison with NaOCl and ClO2. Life cycle cost (LCC) analyses were performed for the tertiary treatment systems studied experimentally and for several other treatment options. A public domain conceptual costing tool (LC3 model) was developed for this purpose. MWW_SF (lime softening and sand filtration) and MWW_NF were the most cost-effective treatment options among the tertiary treatment alternatives considered because of the higher effluent quality with moderate infrastructure costs and the relatively low doses of conditioning chemicals required. Life cycle inventory (LCI) analysis along with integration of external costs of emissions with direct costs was performed to evaluate relative emissions to the environment and external costs associated with construction and operation of tertiary treatment alternatives. Integrated LCI and LCC analysis indicated that three-tiered treatment alternatives such as MWW_NSF and MWW_NFG, with regular chemical addition for treatment and conditioning and/or regeneration, tend to increase the impact costs and in turn the overall costs of tertiary treatment. River water supply and MWW_F alternatives with a single step of tertiary treatment were associated with lower impact costs, but the contribution of impact costs to overall annual costs was higher than all other treatment alternatives. MWW_NF and MWW_SF alternatives exhibited moderate external impact costs with moderate infrastructure and chemical conditioner dosing, which makes them (especially

David Dzombak; Radisav Vidic; Amy Landis

2012-06-30T23:59:59.000Z

489

Four-flavour leading-order hadronic contribution to the muon anomalous magnetic moment  

DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

We present a four-flavour lattice calculation of the leading-order hadronic vacuum polarisation contribution to the anomalous magnetic moment of the muon, a?hvp, arising from quark-connected Feynman graphs. It is based on ensembles featuring Nf=2+1+1 dynamical twisted mass fermions generated by the European Twisted Mass Collaboration (ETMC). Several light quark masses are used in order to yield a controlled extrapolation to the physical pion mass. We employ three lattice spacings to examine lattice artefacts and several different volumes to check for finite-size effects. Including the complete first two generations of quarks allows for a direct comparison with phenomenological determinations of a ?hvp. Our final result involving an estimate of the systematic uncertainty a ?hvp=6.74 (21)(18) 10-8 shows a good overall agreement with these computations.

Burger, Florian [Humboldt U. Berlin; Feng, Xu [KEK; Hotzel, Grit [Humboldt U. Berlin; Jansen, Karl [DESY, Cyprus; Petschlies, Marcus [The Cyprus Institute; Renner, Dru B. [JLAB

2014-02-01T23:59:59.000Z

490

Lattice NRQCD study on in-medium bottomonium spectra using a novel Bayesian reconstruction approach  

E-Print Network [OSTI]

We present recent results on the in-medium modification of S- and P-wave bottomonium states around the deconfinement transition. Our study uses lattice QCD with $N_f=2+1$ light quark flavors to describe the non-perturbative thermal QCD medium between $140$MeV$Maximum Entropy Method. Based on a systematic comparison of interacting and free spectral functions we conclude that the ground states of both the S-wave $(\\Upsilon)$ and P-wave $(\\chi_{b1})$ channel survive up to $T=249$MeV. Stringent upper limits on the size of the in-medium modification of bottomonium masses and widths are provided.

Seyong Kim; Peter Petreczky; Alexander Rothkopf

2014-11-12T23:59:59.000Z

491

Sirt2 suppresses inflammatory responses in collagen-induced arthritis  

SciTech Connect (OSTI)

Highlights: Sirt2 expression decreases in collagen-induced arthritis (CIA). Sirt2 knockout aggravates severity of arthritis in mice with CIA. Sirt2 knockout increases levels of pro-inflammatory factors in the serum. Sirt2 deacetylates p65 and inhibits pro-inflammatory factors expression. Sirt2 rescue abates severity of arthritis in mice with CIA. -- Abstract: Arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications and early death. However, the underling mechanisms of arthritis are still unclear. Sirtuins are a NAD{sup +}-dependent class III deacetylase family, and regulate cellular stress, inflammation, genomic stability, carcinogenesis, and energy metabolism. Among the sirtuin family members, Sirt1 and Sirt6 are critically involved in the development of arthritis. It remains unknown whether other sirtuin family members participate in arthritis. Here in this study, we demonstrate that Sirt2 inhibits collagen-induced arthritis (CIA) using in vivo and in vitro evidence. The protein and mRNA levels of Sirt2 significantly decreased in joint tissues of mice with CIA. When immunized with collagen, Sirt2-KO mice showed aggravated severity of arthritis based on clinical scores, hind paw thickness, and radiological and molecular findings. Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-?B) at lysine 310, resulting in reduced expression of NF-?B-dependent genes, including interleukin 1? (IL-1?), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13. Importantly, our rescue experiment showed that Sirt2 re-expression abated the severity of arthritis in Sirt2-KO mice. Those findings strongly indicate Sirt2 as a considerably inhibitor of the development of arthritis.

Lin, Jiangtao [Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012 (China) [Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012 (China); Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001 (China); Sun, Bing; Jiang, Chuanqiang; Hong, Huanyu [Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001 (China)] [Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001 (China); Zheng, Yanping, E-mail: yanpingzheng@yahoo.com [Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012 (China)] [Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012 (China)

2013-11-29T23:59:59.000Z

492

Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage  

SciTech Connect (OSTI)

Deoxynivalenol (DON), a trichothecene mycotoxin produced by Fusarium that commonly contaminates food, is capable of activating mononuclear phagocytes of the innate immune system via a process termed the ribotoxic stress response (RSR). To encapture global signaling events mediating RSR, we quantified the early temporal (? 30 min) phosphoproteome changes that occurred in RAW 264.7 murine macrophage during exposure to a toxicologically relevant concentration of DON (250 ng/mL). Large-scale phosphoproteomic analysis employing stable isotope labeling of amino acids in cell culture (SILAC) in conjunction with titanium dioxide chromatography revealed that DON significantly upregulated or downregulated phosphorylation of 188 proteins at both known and yet-to-be functionally characterized phosphosites. DON-induced RSR is extremely complex and goes far beyond its prior known capacity to inhibit translation and activate MAPKs. Transcriptional regulation was the main target during early DON-induced RSR, covering over 20% of the altered phosphoproteins as indicated by Gene Ontology annotation and including transcription factors/cofactors and epigenetic modulators. Other biological processes impacted included cell cycle, RNA processing, translation, ribosome biogenesis, monocyte differentiation and cytoskeleton organization. Some of these processes could be mediated by signaling networks involving MAPK-, NF?B-, AKT- and AMPK-linked pathways. Fuzzy c-means clustering revealed that DON-regulated phosphosites could be discretely classified with regard to the kinetics of phosphorylation/dephosphorylation. The cellular response networks identified provide a template for further exploration of the mechanisms of trichothecenemycotoxins and other ribotoxins, and ultimately, could contribute to improved mechanism-based human health risk assessment. - Highlights: ? Mycotoxin deoxynivalenol (DON) induces immunotoxicity via ribotoxic stress response. ? SILAC phosphoproteomics using TiO{sub 2} was applied to DON-treated RAW 264.7 cells. ? DON induces extensive protein phosphorylation changes involving 188 phosphoproteins. ? The main target of early DON-induced RSR is transcriptional regulation. ? Early DON-induced RSR is mediated by MAPK-, NF?B-, AKT- and AMPK-linked pathways.

Pan, Xiao [Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Whitten, Douglas A. [Research Technology Support Facility, Proteomics Core, Michigan State University, East Lansing, MI 48824 (United States); Wu, Ming [Department of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824 (United States); Chan, Christina [Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Department of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824 (United States); Wilkerson, Curtis G. [Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Research Technology Support Facility, Proteomics Core, Michigan State University, East Lansing, MI 48824 (United States); Pestka, James J., E-mail: pestka@msu.edu [Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824 (United States); Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824 (United States)

2013-04-15T23:59:59.000Z

493

Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation  

SciTech Connect (OSTI)

The HGF/Met signaling pathway is deregulated in majority of cancers and is associated with poor prognosis in breast cancer. Delphinidin, present in pigmented fruits and vegetables possesses potent anti-oxidant, anti-inflammatory and anti-angiogenic properties. Here, we assessed the anti-proliferative and anti-invasive effects of delphinidin on HGF-mediated responses in the immortalized MCF-10A breast cell line. Treatment of cells with delphinidin prior to exposure to exogenous HGF resulted in the inhibition of HGF-mediated (i) tyrosyl-phosphorylation and increased expression of Met receptor, (ii) phosphorylation of downstream regulators such as FAK and Src and (iii) induction of adaptor proteins including paxillin, Gab-1 and GRB-2. In addition, delphinidin treatment resulted in significant inhibition of HGF-activated (i) Ras-ERK MAPKs and (ii) PI3K/AKT/mTOR/p70S6K pathways. Delphinidin was found to repress HGF-activated NF{kappa}B transcription with a decrease in (i) phosphorylation of IKK{alpha}/{beta} and I{kappa}B{alpha}, and (ii) activation and nuclear translocation of NF{kappa}B/p65. Inhibition of HGF-mediated membrane translocation of PKC{alpha} as well as decreased phosphorylation of STAT3 was further observed in delphinidin treated cells. Finally, decreased cell viability of Met receptor expressing breast cancer cells treated with delphinidin argues for a potential role of the agent in the prevention of HGF-mediated activation of various signaling pathways implicated in breast cancer.

Syed, Deeba N.; Afaq, Farrukh; Sarfaraz, Sami; Khan, Naghma; Kedlaya, Rajendra; Setaluri, Vijayasaradhi [Department of Dermatology, University of Wisconsin, Madison (United States); Mukhtar, Hasan [Department of Dermatology, University of Wisconsin, Madison (United States)], E-mail: hmukhtar@wisc.edu

2008-08-15T23:59:59.000Z

494

Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis  

SciTech Connect (OSTI)

Hyperlipidemia, inflammation and altered antioxidant profiles are the usual complications in diabetes mellitus. In the present study, we investigated the therapeutic potential of taurine in diabetes associated cardiac complications using a rat model. Rats were made diabetic by alloxan (ALX) (single i.p. dose of 120 mg/kg body weight) and left untreated or treated with taurine (1% w/v, orally, in water) for three weeks either from the day of ALX exposure or after the onset of diabetes. Animals were euthanized after three weeks. ALX-induced diabetes decreased body weight, increased glucose level, decreased insulin content, enhanced the levels of cardiac damage markers and altered lipid profile in the plasma. Moreover, it increased oxidative stress (decreased antioxidant enzyme activities and GSH/GSSG ratio, increased xanthine oxidase enzyme activity, lipid peroxidation, protein carbonylation and ROS generation) and enhanced the proinflammatory cytokines levels, activity of myeloperoxidase and nuclear translocation of NF?B in the cardiac tissue of the experimental animals. Taurine treatment could, however, result to a decrease in the elevated blood glucose and proinflammatory cytokine levels, diabetes-evoked oxidative stress, lipid profiles and NF?B translocation. In addition, taurine increased GLUT 4 translocation to the cardiac membrane by enhanced phosphorylation of IR and IRS1 at tyrosine and Akt at serine residue in the heart. Results also suggest that taurine could protect cardiac tissue from ALX induced apoptosis via the regulation of Bcl2 family and caspase 9/3 proteins. Taken together, taurine supplementation in regular diet could play a beneficial role in regulating diabetes and its associated complications in the heart. Highlights: ? Taurine controls blood glucose via protection of pancreatic ? cells in diabetic rat. ? Taurine controls blood glucose via increasing the insulin level in diabetic rat. ? Taurine improves cardiac AKT/GLUT4 signaling pathways in diabetic conditions. ? Taurine exerts antioxidant, antihyperlipidemic and antiinflammatory activities. ? It protects cardiac apoptosis by regulating Bcl2 family and caspase 9/3 proteins.

Das, Joydeep; Vasan, Vandana; Sil, Parames C., E-mail: parames@bosemain.boseinst.ac.in

2012-01-15T23:59:59.000Z

495

New therapeutic aspect for carvedilol: Antifibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damage  

SciTech Connect (OSTI)

Portal hypertension is a common complication of chronic liver diseases associated with liver fibrosis and cirrhosis. At present, beta-blockers such as carvedilol remain the medical treatment of choice for protection against variceal bleeding and other complications. Since carvedilol has powerful antioxidant properties we assessed the potential antifibrotic effects of carvedilol and the underlying mechanisms that may add further benefits for its clinical usefulness using a chronic model of carbon tetrachloride (CCl4)-induced hepatotoxicity. Two weeks after CCl4 induction of chronic hepatotoxicity, rats were co-treated with carvedilol (10 mg/kg, orally) daily for 6 weeks. It was found that treatment of animals with carvedilol significantly counteracted the changes in liver function and histopathological lesions induced by CCl4. Also, carvedilol significantly counteracted lipid peroxidation, GSH depletion, and reduction in antioxidant enzyme activities; glutathione-S-transferase and catalase that was induced by CCl4. In addition, carvedilol ameliorated the inflammation induced by CCl4 as indicated by reducing the serum level of acute phase protein marker; alpha-2-macroglobulin and the liver expression of nuclear factor-kappa B (NF-?B). Finally, carvedilol significantly reduced liver fibrosis markers including hydroxyproline, collagen accumulation, and the expression of the hepatic stellate cell (HSC) activation marker; alpha smooth muscle actin. In conclusion, the present study provides evidences for the promising antifibrotic effects of carvedilol that can be explained by amelioration of oxidative stress through mainly, replenishment of GSH, restoration of antioxidant enzyme activities and reduction of lipid peroxides as well as amelioration of inflammation and fibrosis by decreasing collagen accumulation, acute phase protein level, NF-?B expression and finally HSC activation. -- Highlights: ? Carvedilol is a beta blocker with antioxidant and antifibrotic properties. ? It restores GSH and antioxidant enzyme activities and reduces lipid peroxidation. ? It ameliorates inflammation and nuclear factor kappa-B expression. ? It ameliorates fibrosis by decreasing collagen accumulation and HSC activation.

Hamdy, Nadia [Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); El-Demerdash, Ebtehal, E-mail: ebtehal_dm@yahoo.com [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)

2012-06-15T23:59:59.000Z

496

Spent nuclear fuel reprocessing modeling  

SciTech Connect (OSTI)

The long-term wide development of nuclear power requires new approaches towards the realization of nuclear fuel cycle, namely, closed nuclear fuel cycle (CNFC) with respect to fission materials. Plant nuclear fuel cycle (PNFC), which is in fact the reprocessing of spent nuclear fuel unloaded from the reactor and the production of new nuclear fuel (NF) at the same place together with reactor plant, can be one variant of CNFC. Developing and projecting of PNFC is a complicated high-technology innovative process that requires modern information support. One of the components of this information support is developed by the authors. This component is the programme conducting calculations for various variants of process flow sheets for reprocessing SNF and production of NF. Central in this programme is the blocks library, where the blocks contain mathematical description of separate processes and operations. The calculating programme itself has such a structure that one can configure the complex of blocks and correlations between blocks, appropriate for any given flow sheet. For the ready sequence of operations balance calculations are made of all flows, i.e. expenses, element and substance makeup, heat emission and radiation rate are determined. The programme is open and the block library can be updated. This means that more complicated and detailed models of technological processes will be added to the library basing on the results of testing processes using real equipment, in test operating mode. The development of the model for the realization of technical-economic analysis of various variants of technologic PNFC schemes and the organization of 'operator's advisor' is expected. (authors)

Tretyakova, S.; Shmidt, O.; Podymova, T.; Shadrin, A.; Tkachenko, V. [Bochvar Institute, 5 Rogova str., Moscow 123098 (Russian Federation); Makeyeva, I.; Tkachenko, V.; Verbitskaya, O.; Schultz, O.; Peshkichev, I. [Russian Federal Nuclear Center - VNIITF E.I. Zababakhin, p.o.box 245, Snezhinsk, 456770 (Russian Federation)

2013-07-01T23:59:59.000Z

497

Neutrino-electron scattering in a magnetic field with allowance for polarizations of electrons  

SciTech Connect (OSTI)

We present an analytic formula for differential cross section (DCS) of neutrino-electron scattering (NES) in a magnetic field (MF) with allowance for longitudinal polarizations of initial and final electrons (IAFE). The DCS of NES in a MF is sensitive to the spin variable of the IAFE and to the direction of the incident and scattered neutrinos (IASN) momenta. Spin asymmetries and field effects in NES in a MF enable us to use initial electrons having a left-hand circular polarization (LHCP) as polarized electron targets in detectors for detection of low-energy neutrinos or relic neutrinos and for distinguishing neutrino flavor (NF). In general, gas consisting of only electrons having a LHCP and gas consisting of only electrons having a right-hand circular polarization (RHCP) are heated by neutrinos asymmetrically. The asymmetry of heating (AH) is sensitive to NF, MF strength, energies (Landau quantum numbers and third components of the momenta) of IAFE, final electron chemical potential, the final temperature of gas consisting of only electrons having a LHCP (RHCP), polar angles of IASN momenta, the difference between the azimuthal angles of IASN momenta, the angle {phi}, and IASN energies. In the heating process of electrons by neutrinos the dominant role belongs to electron neutrinos compared with the contribution of muon (tauon) neutrinos. Electrons having a LHCP in NES in a MF are heated by {nu}{sub e} and {nu}{sub {mu}}({nu}{sub {tau}}) unequally when both the IASN fly along or against the MF direction. For magnetars and neutrinos of 1 MeV energy, within the considered kinematics, the AH in an electron neutrino-electron scattering is 2.23 times that in a muon neutrino-electron scattering or in a tauon neutrino-electron scattering.

Guseinov, V. A. [Department of General and Theoretical Physics, Nakhchivan State University, AZ 7000, Nakhchivan (Azerbaijan); Laboratory of Physical Research, Nakhchivan Division of Azerbaijan National Academy of Sciences, AZ 7000, Nakhchivan (Azerbaijan); Jafarov, I. G. [Department of Theoretical Physics and Astrophysics, Azerbaijan State Pedagogical University, Baku (Azerbaijan); Gasimova, R. E. [Department of General and Theoretical Physics, Nakhchivan State University, AZ 7000, Nakhchivan (Azerbaijan)

2007-04-01T23:59:59.000Z

498

Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression  

SciTech Connect (OSTI)

Environmental exposure to arsenic is known to cause various cancers. There are some potential relationships between cell malignant transformation and C-X-C chemokine receptor type 4 (CXCR4) expressions. Metastasis, one of the major characteristics of malignantly transformed cells, contributes to the high mortality of cells. CXCR4 and its natural chemokine ligand C-X-C motif ligand 12 (CXCL12) play a critical role in metastasis. Therefore, identification of nutritional factors which are able to inhibit CXCR4 is important for protection from environmental arsenic-induced carcinogenesis and for abolishing metastasis of malignantly transformed cells. The present study demonstrates that apigenin (4?,5,7-trihydroxyflavone), a natural dietary flavonoid, suppressed CXCR4 expression in arsenic-transformed Beas-2B cells (B-AsT) and several other types of transformed/cancer cells in a dose- and time-dependent manner. Neither proteasome nor lysosome inhibitor had any effect in reducing the apigenin-induced down-regulation of CXCR4, indicating that apigenin-induced down-regulation of CXCR4 is not due to proteolytic degradation. The down-regulation of CXCR4 is mainly due to the inhibition of nuclear factor ?B (NF-?B) transcriptional activity. Apigenin also abolished migration and invasion of transformed cells induced by CXCL12. In a xenograft mouse model, apigenin down-regulated CXCR4 expression and suppressed tumor growth. Taken together, our results show that apigenin is a novel inhibitor of CXCR4 expression. This dietary flavonoid has the potential to suppress migration and invasion of transformed cells and prevent environmental arsenic-induced carcinogenesis. - Highlights: Apigenin has a potential in preventing environmental arsenic induced carcinogenesis. Apigenin suppresses CXCR4 in malignant transformed cells in vitro and in vivo. The down-regulation of CXCR4 is mainly due to inhibition of NF-?B activity.

Wang, Lei; Kuang, Lisha; Hitron, John Andrew; Son, Young-Ok; Wang, Xin; Budhraja, Amit [Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 (United States); Lee, Jeong-Chae [Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 (United States); Institute of Oral Biosciences and BK21 Program, Research Center of Bioactive Materials, Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Pratheeshkumar, Poyil [Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 (United States); Chen, Gang [Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY 40536 (United States); Zhang, Zhuo [Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 (United States); Luo, Jia [Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY 40536 (United States); Shi, Xianglin, E-mail: xshi5@email.uky.edu [Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 (United States)

2013-10-01T23:59:59.000Z

499

Code qualification of structural materials for AFCI advanced recycling reactors.  

SciTech Connect (OSTI)

This report summarizes the further findings from the assessments of current status and future needs in code qualification and licensing of reference structural materials and new advanced alloys for advanced recycling reactors (ARRs) in support of Advanced Fuel Cycle Initiative (AFCI). The work is a combined effort between Argonne National Laboratory (ANL) and Oak Ridge National Laboratory (ORNL) with ANL as the technical lead, as part of Advanced Structural Materials Program for AFCI Reactor Campaign. The report is the second deliverable in FY08 (M505011401) under the work package 'Advanced Materials Code Qualification'. The overall objective of the Advanced Materials Code Qualification project is to evaluate key requirements for the ASME Code qualification and the Nuclear Regulatory Commission (NRC) approval of structural materials in support of the design and licensing of the ARR. Advanced materials are a critical element in the development of sodium reactor technologies. Enhanced materials performance not only improves safety margins and provides design flexibility, but also is essential for the economics of future advanced sodium reactors. Code qualification and licensing of advanced materials are prominent needs for developing and implementing advanced sodium reactor technologies. Nuclear structural component design in the U.S. must comply with the ASME Boiler and Pressure Vessel Code Section III (Rules for Construction of Nuclear Facility Components) and the NRC grants the operational license. As the ARR will operate at higher temperatures than the