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Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System  

E-Print Network [OSTI]

Hydrophobic drug paclitaxel nanoparticles (PAX NPs) and pH sensitive hydrogels were prepared in this study to build a colon targeting nanoparticle based drug delivery system for oral administration. Negative charged PAX NPs at the size of 110...

Yu, Xiao

2012-07-16T23:59:59.000Z

2

Synthetic LDL as targeted drug delivery vehicle  

DOE Patents [OSTI]

The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

2012-08-28T23:59:59.000Z

3

Design, Synthesis and Development of Transporter Targeting Agents for Image-guided Therapy and Drug Delivery.  

E-Print Network [OSTI]

?? The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents,… (more)

Tsao, Ning

2013-01-01T23:59:59.000Z

4

Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery  

E-Print Network [OSTI]

The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

Tan, Mei Chee

5

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network [OSTI]

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

6

Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme  

SciTech Connect (OSTI)

This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu,Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-06-14T23:59:59.000Z

7

Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)  

ScienceCinema (OSTI)

Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

Forte, Trudy

2011-04-28T23:59:59.000Z

8

Temporary blood?brain barrier disruption via focused ultrasound for targeted drug delivery in the brain  

Science Journals Connector (OSTI)

The ability to deliver drugs to the central nervous system is severely limited by the presence of the blood?brain barrier (BBB). This barrier normally serves to protect the brain and restricts the passage of most molecules from being delivered to the brain tissue from the blood stream. We have developed a method by which the BBB is temporarily disrupted in localized regions using low?power ultrasound pulses combined with a circulating ultrasound contrast agent. By systematically focusing at multiple overlapping locations one could prescribe the region in which the BBB is disrupted to conform to a desired target volume reducing drug penetration to the rest of the brain.Ultrasound parameters suited for this procedure are compatible with a device that can focus through the intact skull. In this presentation we will describe recent research on this technique discussing methodology safety possible mechanisms and potential means to guide and monitor the procedure.

Nathan McDannold

2007-01-01T23:59:59.000Z

9

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

10

Controlling drug delivery across the placenta: A commentary  

E-Print Network [OSTI]

A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

Audus, Kenneth L.

1999-01-01T23:59:59.000Z

11

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer  

Science Journals Connector (OSTI)

...Molecular Targets, and Chemical Biology Nanoparticle Targeting of Anticancer Drug Improves...14263. Prior studies suggested that nanoparticle drug delivery might improve the therapeutic...responses not possible with a free drug. Nanoparticle|drug delivery|PAMAM dendrimer...

Jolanta F. Kukowska-Latallo; Kimberly A. Candido; Zhengyi Cao; Shraddha S. Nigavekar; Istvan J. Majoros; Thommey P. Thomas; Lajos P. Balogh; Mohamed K. Khan; James R. Baker, Jr.

2005-06-15T23:59:59.000Z

12

Liposomes in Drug Targeting  

Science Journals Connector (OSTI)

Transport of drugs to target tissues, cells or subcellular organelles by the use of carrier systems is now a recognized useful method of improving drug selectivity. The types of carrier that have been proposed...

G. Gregoriadis

1980-01-01T23:59:59.000Z

13

Protein-Based Nanomedicine Platforms for Drug Delivery. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Protein-Based Nanomedicine Platforms for Drug Delivery. Protein-Based Nanomedicine Platforms for Drug Delivery. Abstract: Drug delivery systems have been developed for many years,...

14

Iontophoretic drug delivery system: A review  

Science Journals Connector (OSTI)

Among the recent developments in the field of transdermal drug delivery, iontophoresis has emerged as a very promising tool for this purpose. Various studies have been performed on drug delivery through the skin using electric current. Iontophoresis ... Keywords: Iontophoresis, iontophoretic systems, transdermal drug delivery

Ajay Semalty; Mona Semalty; Ranjit Singh; Shailendra K. Saraf; Shubhini Saraf

2007-09-01T23:59:59.000Z

15

Targeted Nanomedicine for Suppression of CD44 and Simultaneous Cell Death Induction in Ovarian Cancer: An Optimal Delivery of siRNA and Anticancer Drug  

Science Journals Connector (OSTI)

...San Diego, CA Imparting superior control on materials for nanomedicine: The study of degradable, targeted PRINT nanoparticles...development of an effective platform delivery system for use in nanomedicine. Our technique, called PRINT (Particle Replication In...

Vatsal Shah; Oleh Taratula; Olga B. Garbuzenko; Olena R. Taratula; Lorna Rodriguez-Rodriguez; Tamara Minko

2013-11-15T23:59:59.000Z

16

Apoferritin-based nanomedicine platform for drug delivery: equilibrium...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

17

Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs  

E-Print Network [OSTI]

Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

Stauber, Zachary Jason

2012-01-01T23:59:59.000Z

18

Preparation of ?-Fe2O3/SiO2-capsule composites capable of using as drug delivery and magnetic targeting system from hydrophobic iron acetylacetonate and hydrophilic SiO2-capsule  

Science Journals Connector (OSTI)

Abstract Series of nanocomposites with ?-Fe2O3 supported on SiO2-capsules were prepared by adsorption of hydrophobic iron acetylacetonate on the hydrophilic surface of SiO2-capsules in the evaporation process of the solvent and then calcination the complex at 450 °C. The adsorption and calcination conditions were studied and the resultant nanaoparticles were characterized by XRD, XRF and TEM in detail. The results indicated that ?-Fe2O3 loaded discontinuously but uniformly on the surface of SiO2-capsules at appropriate content. The specific surface area characterization and doxorubicin hydrochloride release shown although the surface area of the target composites decreased slightly, the nanoparticles still had large potential using as drug delivery and magnetic targeting system.

Fengzhu Lv; Liling Fu; Emmanuel P. Giannelis; Genggeng Qi

2014-01-01T23:59:59.000Z

19

Protein-Based Nanomedicine Platforms for Drug Delivery  

SciTech Connect (OSTI)

Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drug’s efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

2009-08-03T23:59:59.000Z

20

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network [OSTI]

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Nano compartments may aid drug delivery, catalyst design > Archived...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nano compartments may aid drug delivery, catalyst design April 18th, 2013 By Bill Steele Spongelike nanoparticles whose pores can be filled with drugs offer the promise of drug...

22

Mechanism of Binding and Internalization of ICAM-1-derived Cyclic Peptides by LFA-1 on the Surface of T-cells: A Potential Method for Targeted Drug Delivery  

E-Print Network [OSTI]

Purpose Peptides derived from the Domain 1 of the adhesion molecule ICAM-1(1-21) are being developed as targeting ligands for LFA-1 receptors expressed on activated T-cells. This work aims to elucidate the binding and ...

Anderson, Meagan E.; Siahaan, Teruna J.

2003-10-01T23:59:59.000Z

23

Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery  

Science Journals Connector (OSTI)

Abstract Considerable effort has been directed towards developing novel drug delivery systems. Microfluidics, capable of generating monodisperse single and multiple emulsion droplets, executing precise control and operations on these droplets, is a powerful tool for fabricating complex systems (microparticles, microcapsules, microgels) with uniform size, narrow size distribution and desired properties, which have great potential in drug delivery applications. This review presents an overview of the state-of-the-art multiphase flow microfluidics for the production of single emulsions or multiple emulsions for drug delivery. The review starts with a brief introduction of the approaches for making single and multiple emulsions, followed by presentation of some potential drug delivery systems (microparticles, microcapsules and microgels) fabricated in microfluidic devices using single or multiple emulsions as templates. The design principles, manufacturing processes and properties of these drug delivery systems are also discussed and compared. Furthermore, drug encapsulation and drug release (including passive and active controlled release) are provided and compared highlighting some key findings and insights. Finally, site-targeting delivery using multiphase flow microfluidics is also briefly introduced.

Chun-Xia Zhao

2013-01-01T23:59:59.000Z

24

E-Print Network 3.0 - active drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Drug Delivery, Bionanotechnology and Molecular Recognition, Departments... 78712, USA Recent advances in the discovery and delivery of drugs to cure chronic diseases are...

25

Needle-free drug delivery using shock wave techniques  

E-Print Network [OSTI]

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01T23:59:59.000Z

26

An emerging platform for drug delivery: Aerogel based systems  

Science Journals Connector (OSTI)

Abstract Over the past few decades, advances in “aerogel science” have provoked an increasing interest for these materials in pharmaceutical sciences for drug delivery applications. Because of their high surface areas, high porosities and open pore structures which can be tuned and controlled by manipulation of synthesis conditions, nanostructured aerogels represent a promising class of materials for delivery of various drugs as well as enzymes and proteins. Along with biocompatible inorganic aerogels and biodegradable organic aerogels, more complex systems such as surface functionalized aerogels, composite aerogels and layered aerogels have also been under development and possess huge potential. Emphasis is given to the details of the aerogel synthesis and drug loading methods as well as the influence of synthesis parameters and loading methods on the adsorption and release of the drugs. Owing to their ability to increase the bioavailability of low solubility drugs, to improve both their stability and their release kinetics, there are an increasing number of research articles concerning aerogels in different drug delivery applications. This review presents an up to date overview of the advances in all kinds of aerogel based drug delivery systems which are currently under investigation.

Zeynep Ulker; Can Erkey

2014-01-01T23:59:59.000Z

27

Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance  

E-Print Network [OSTI]

period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

Clairambault, Jean

28

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring  

Science Journals Connector (OSTI)

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring ... Lipid-Based Nanomedicines for Cancer ...

Yoshihisa Namiki; Teruaki Fuchigami; Norio Tada; Ryo Kawamura; Satoshi Matsunuma; Yoshitaka Kitamoto; Masaru Nakagawa

2011-07-26T23:59:59.000Z

29

Local drug delivery for enhancing fracture healing in osteoporotic bone  

Science Journals Connector (OSTI)

Abstract Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an osteoporotic fracture is challenging due to the decreased strength of the surrounding bone and suboptimal healing capacity, predisposing both to fixation failure and non-union. Whereas a systemic osteoporosis treatment acts slowly, local release of osteogenic agents in osteoporotic fracture would act rapidly to increase bone strength and quality, as well as to reduce the bone healing period and prevent development of a problematic non-union. The identification of agents with potential to stimulate bone formation and improve implant fixation strength in osteoporotic bone has raised hope for the fast augmentation of osteoporotic fractures. Stimulation of bone formation by local delivery of growth factors is an approach already in clinical use for the treatment of non-unions, and could be utilized for osteoporotic fractures as well. Small molecules have also gained ground as stable and inexpensive compounds to enhance bone formation and tackle osteoporosis. The aim of this paper is to present the state of the art on local drug delivery in osteoporotic fractures. Advantages, disadvantages and underlying molecular mechanisms of different active species for local bone healing in osteoporotic bone are discussed. This review also identifies promising new candidate molecules and innovative approaches for the local drug delivery in osteoporotic bone.

Laura Kyllönen; Matteo D’Este; Mauro Alini; David Eglin

2014-01-01T23:59:59.000Z

30

Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors  

Science Journals Connector (OSTI)

...mum of tissue, using a 543 excitation laser and LP 560 emission filter. A plane approximately...to local tumors can be thought of as the fusion of 2 traditional approaches to drug delivery...Ther 2010;9:1798-808. 11. Dvorak HF , Nagy JA, Dvorak JT Dvorak AM.Identification...

Ashley A. Manzoor; Lars H. Lindner; Chelsea D. Landon; Ji-Young Park; Andrew J. Simnick; Matthew R. Dreher; Shiva Das; Gabi Hanna; Won Park; Ashutosh Chilkoti; Gerben A. Koning; Timo L.M. ten Hagen; David Needham; and Mark W. Dewhirst

2012-11-01T23:59:59.000Z

31

E-Print Network 3.0 - advanced drug delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Nano-scale Delivery: Impact on Absorption and Nicholas A. Peppas Summary: 78712, USA Recent advances in the discovery and delivery of drugs to cure chronic diseases are...

32

Multiscale modeling and uncertainty quantification in nanoparticle-mediated drug/gene delivery  

Science Journals Connector (OSTI)

Nanoparticle (NP)-mediated drug/gene delivery involves phenomena at broad range spatial and temporal scales. The interplay between these phenomena makes the NP-mediated drug/gene delivery process very complex. In this paper, we have identified four key ... Keywords: Coarse-grained molecular dynamics, Drug delivery, Fluid-structure interaction, Immersed molecular electrokinetic finite element, Molecular mean-field theory, Multiscale modeling

Ying Li, Wylie Stroberg, Tae-Rin Lee, Han Sung Kim, Han Man, Dean Ho, Paolo Decuzzi, Wing Kam Liu

2014-03-01T23:59:59.000Z

33

Novel Polysaccharide Based Polymers and Nanoparticles for Controlled Drug Delivery and Biomedical Imaging.  

E-Print Network [OSTI]

??The use of polysaccharides as building blocks in the development of drugs and contrast agents delivery systems is rapidly growing. This can be attributed to… (more)

Shalviri, Alireza

2013-01-01T23:59:59.000Z

34

Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes  

E-Print Network [OSTI]

Theranostics 2011, 1 http://www.thno.org 277 Theranostics 2011; 1:277-289 Research Paper Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes Prakash Manikwar1, Bimo A. Tejo1,2, Heather Shinogle3, David S... via a unique pathway Theranostics 2011, 1 http://www.thno.org 278 referred to as CAM-mediated endocytosis [10-13]. Ligands that bind to CAM can be used to selectively target drugs for intracellular delivery to immune cells expressing...

Manikwar, Prakash; Tejo, Bimo A.; Shinogle, Heather; Moore, David S.; Zimmerman, Tahl; Blanco, Francisco; Siahaan, Teruna J.

2010-05-10T23:59:59.000Z

35

The dual-piston jet injector and the viability of drug delivery  

E-Print Network [OSTI]

Drug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently ...

Cunningham, Daniel (Daniel P.)

2007-01-01T23:59:59.000Z

36

Drugs: A tangled web of targets  

Science Journals Connector (OSTI)

... was a good year. The US Food and Drug Administration (FDA) had just approved memantine, the first in a class of drugs that reduces abnormal brain activity. Scientists had ... based on each, and the field seemed to be moving in the right direction. Memantine is one of several drugs on the market in Europe and the United States that ...

Lauren Gravitz

2011-07-13T23:59:59.000Z

37

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

38

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

39

A review of age-old antimalarial drug to combat malaria: efficacy up-gradation by nanotechnology based drug delivery  

Science Journals Connector (OSTI)

Abstract Malaria is uncontrolled burden in the world till now. Despite of different efforts to develop antimalarial drug for decades, any anti-malarial drug can able to eradicate completely till now. Many anti-malarial substances are practically ineffectual because of their physicochemical limitations, cytotoxicity, chemical instability and degradation, and limited activities against intracellular parasites. Taking into consideration, the amount of research is going to conduct in the field of nanoparticle based drug delivery systems, lead to new ways of improving the treatment of infectious diseases. The study has focused on the progress and advancement of research on nanotechnology based drug delivery to eradicate the malaria. We like to focus the efficacy of nanotechnology based drug application for the opening out of novel chemotherapeutics in laboratory research, which may show the way to better use with age-old antimalarial drug and may draw the attention of pharmaceutical industries for the improvement and designing of effective anti-malarial drugs in future.

Satyajit Tripathy; Somenath Roy

2014-01-01T23:59:59.000Z

40

Nanomedicine: making controllable magnetic drug delivery possible for the treatment of breast cancer  

Science Journals Connector (OSTI)

A recent study published in Nano Letters documents the synthesis and performance of porous silica nanocapsules filled with magnetic nanoparticles as a controllable magnetic drug delivery vector. Under a remotely ...

Lesa A Tran; Lon J Wilson

2011-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Thermo-responsive Layer-by-Layer Assemblies for Nanoparticle-based Drug Delivery  

E-Print Network [OSTI]

release in response to temperature is still challenging. Here, a thermo-responsive drug delivery system of solid dexamethasone nanoparticles (DXM NPs) encapsulated in a model LbL assembly of strong polyelectrolytes poly (diallyldimethylammonium chloride...

Zhou, Jing

2013-11-26T23:59:59.000Z

42

Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device  

E-Print Network [OSTI]

The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release ...

Li, Yawen, 1972-

2005-01-01T23:59:59.000Z

43

Amphiphilic gold nanoparticles: mechanisms for interaction with membranes and applications in drug and vaccine delivery  

E-Print Network [OSTI]

Materials that can interact with and transit membranes without toxic bilayer disruption or poration are of great interest in the drug delivery field. These materials can presumably bypass endocytosis to directly enter the ...

Atukorale, Prabhani U. (Prabhani Upeka)

2014-01-01T23:59:59.000Z

44

Enhancing pharmaceutical formulations to improve efficacy and delivery of drug molecules  

E-Print Network [OSTI]

Major impediments to the full utility of current and potential drugs include issues of resistance and delivery. To address these challenges, in this thesis two directions of research were pursued: (1) the use of multivalent ...

Weight, Alisha K. (Alisha Kessel)

2013-01-01T23:59:59.000Z

45

Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs  

Science Journals Connector (OSTI)

Abstract Gadolinium (Gd) contrast agents are predominantly used for T1 MR imaging. However, the high toxicity of Gd3 + and potential side effects including nephrogenic systemic fibrosis have led to the search for alternative T1 contrast agents. Since manganese (Mn) has paramagnetic properties with five unpaired electrons that permit high spin number, long electronic relaxation times, and labile water exchange, we evaluated Mn as a T1 magnetic resonance imaging (MRI) contrast agent for lung imaging. Here we report on the design and synthesis of multifunctional lipid-micellar nanoparticles (LMNs) containing Mn oxide (M-LMNs) for MRI that can also be used for DNA and drug delivery. Oleic acid-coated MnO nanoparticles were encapsulated in micelles composed of polyethylene glycol (PEG-2000), phosphatidylethanolamine (PE), DC-cholesterol, and dioleoyl-phosphatidylethanolamine (DOPE). The particles are taken up in vitro by human embryonic kidney (HEK293), Lewis lung carcinoma (LLC1), and A549 cells and are devoid of cytotoxicity. When administered to mice intranasally, they preferentially accumulate in the lungs. In vitro phantom and ex vivo lung MRI results confirmed that M-LMNs are able to enhance T1 MRI contrast. M-LMNs loaded with plasmid DNA and/or doxorubicin are efficiently taken up by HEK293 cells in vitro and by target cells in vivo. Taken together, these results demonstrate that M-LMNs are capable of simultaneously providing MRI contrast and DNA and/or drug delivery to target cells in the lung and therefore may prove useful as a lung theranostic, especially for lung cancers.

M. Howell; J. Mallela; C. Wang; S. Ravi; S. Dixit; U. Garapati; S. Mohapatra

2013-01-01T23:59:59.000Z

46

Abstract CN01-02: canSAR: An integrated cancer drug discovery informatics platform allowing systematic target evaluation.  

Science Journals Connector (OSTI)

...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...nanogels: a versatile platform for drug delivery to...drugs, due to their chemical composition, are unsuitable...nanogel drug delivery platform that can (i) encapsulate...

Bissan Al-Lazikani; Mishal Patel; Krishna Bulusu; and Mark Halling-Brown

2011-11-01T23:59:59.000Z

47

Quantification of Mesenchymal Stem Cell (MSC) Delivery to a Target Site Using In Vivo Confocal Microscopy  

E-Print Network [OSTI]

The ability to deliver cells to appropriate target tissues is a prerequisite for successful cell-based therapy. To optimize cell therapy it is therefore necessary to develop a robust method of in vivo cell delivery ...

Mortensen, Luke J.

48

Toward a drug delivery coating for intraocular lenses  

E-Print Network [OSTI]

Layer-by-layer assembly has become a quintessential tool for the creation of versatile, dynamic nanostructured materials able to dictate cellular behavior through exquisite surface functionality and delivery of bioactive ...

Smith, Renée Chivon

2010-01-01T23:59:59.000Z

49

A nano-immunoassay system for monitoring targeted drug impact on signaling pathways from small samples of primary hematopoietic malignancies  

Science Journals Connector (OSTI)

...An evaluation of the role of Mucin in nano drug delivery. Musaed Allkholief Robert...determine the role of mucin in the delivery of nano-sized drug delivery systems. Methods...An evaluation of the role of Mucin in nano drug delivery. [abstract]. In: Proceedings...

Alice Fan; Wilhelm Lachnit; Debabrita Deb-Basu; David Voehringer; Dean Felsher

2007-11-15T23:59:59.000Z

50

Targeted Nanogels: A Versatile Platform for Drug Delivery to Tumors  

Science Journals Connector (OSTI)

...a prime operation platform for implementation of chemical reactions (12-15...operation of complicated chemical (19, 20) and biological...in stand-alone platforms. PDMS devices are...devices coupled to chemical and physical changes...

Eric A. Murphy; Bharat K. Majeti; Rajesh Mukthavaram; Lisette M. Acevedo; Leo A. Barnes; and David A. Cheresh

2011-06-01T23:59:59.000Z

51

Polysaccharide-based aerogel microspheres for oral drug delivery  

Science Journals Connector (OSTI)

Abstract Polysaccharide-based aerogels in the form of microspheres were investigated as carriers of poorly water soluble drugs for oral administration. These bio-based carriers may combine the biocompatibility of polysaccharides and the enhanced drug loading capacity of dry aerogels. Aerogel microspheres from starch, pectin and alginate were loaded with ketoprofen (anti-inflammatory drug) and benzoic acid (used in the management of urea cycle disorders) via supercritical CO2-assisted adsorption. Amount of drug loaded depended on the aerogel matrix structure and composition and reached values up to 1.0 × 10?3 and 1.7 × 10?3 g/m2 for ketoprofen and benzoic acid in starch microspheres. After impregnation, drugs were in the amorphous state in the aerogel microspheres. Release behavior was evaluated in different pH media (pH 1.2 and 6.8). Controlled drug release from pectin and alginate aerogel microspheres fitted Gallagher-Corrigan release model (R2 > 0.99 in both cases), with different relative contribution of erosion and diffusion mechanisms depending on the matrix composition. Release from starch aerogel microspheres was driven by dissolution, fitting the first-order kinetics due to the rigid starch aerogel structure, and showed different release rate constant (k1) depending on the drug (0.075 and 0.160 min?1 for ketoprofen and benzoic acid, respectively). Overall, the results point out the possibilities of tuning drug loading and release by carefully choosing the polysaccharide used to prepare the aerogels.

C.A. García-González; M. Jin; J. Gerth; C. Alvarez-Lorenzo; I. Smirnova

2014-01-01T23:59:59.000Z

52

Targeted and stimuli-responsive polymers as chemotherapeutic delivery systems  

E-Print Network [OSTI]

Successful administration of chemotherapeutic agents for cancer treatment requires a balance between the efficacy and the safety of the drug. This often limits physicians to a very narrow therapeutic window. To avoid the ...

Zaman, Noreen Tasneem

2008-01-01T23:59:59.000Z

53

Protein engineering for targeted delivery of radionuclides to tumors  

E-Print Network [OSTI]

Traditional cancer treatment strategies include systemic chemotherapy, external beam radiation, and surgical excision. Chemotherapy is nonspecific, and targets all rapidly dividing cells. External beam radiation and surgery ...

Orcutt, Kelly Davis

2010-01-01T23:59:59.000Z

54

Targeting atherosclerosis : nanoparticle delivery for diagnosis and treatment  

E-Print Network [OSTI]

Biomimetic amplification of nanoparticle homing to tumors."Biomimetic amplification of nanoparticle homing to tumors."a novel target for nanoparticle-based diagnostics and

Peters, David Thomas

2009-01-01T23:59:59.000Z

55

Towards engineering hormone-binding globulins as drug delivery agents  

E-Print Network [OSTI]

directly for destruction by the body’s immune system. There are currently three antibody-drug conjugates and 11 ‘naked’ monoclonal antibodies approved by the Food and Drug Administration for the treatment of cancers [9, 10]. Another form of immunotherapy... efficacy in many cases [50]. Currently, the most common chemotherapeutic treatment for malignant metastatic prostate cancer is docetaxel, a mitotic poison [51]. In the next part of this proof-of-concept experiment, we sought to show that it is possible...

Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

2014-11-26T23:59:59.000Z

56

CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data  

E-Print Network [OSTI]

CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery t Enhanced condensational growth (ECG) is a newly proposed concept for respiratory drug delivery in which and evaluate a CFD model of ECG in a simple tubular geometry with direct comparisons to in vitro results

Frey, Pascal

57

A PARYLENE BELLOWS ELECTROCHEMICAL ACTUATOR FOR INTRAOCULAR DRUG DELIVERY  

E-Print Network [OSTI]

Implant INTRODUCTION Water electrolysis using coplanar microelectrodes offers a promising pumping with the contents of the drug reservoir. Electrolysis-induced gas generation (phase change of water into hydrogen) water and then joined together (Figure 2). Electrolysis pumping is selected over other actuation methods

Meng, Ellis

58

In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities  

Science Journals Connector (OSTI)

...delivery of poorly water-soluble (hydrophobic...considered poorly water-soluble, using...Classification System for drug solubility (1). The conventional...prototype for a poorly water-soluble, hydrophobic...an initiator in a nitrogen (N2) atmosphere...passing nitrogen gas for 30 min. Thereafter...

Savita Bisht; Georg Feldmann; Jan-Bart M. Koorstra; Michael Mullendore; Hector Alvarez; Collins Karikari; Michelle A. Rudek; Carlton K. Lee; Amarnath Maitra; and Anirban Maitra

2008-12-01T23:59:59.000Z

59

A Key Target for Diabetes Drugs | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Molten Metal Solidifies into a New Kind of Glass Molten Metal Solidifies into a New Kind of Glass Organic Polymers Show Sunny Potential A New Family of Quasicrystals Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor, which could help scientists design new drugs for type 2 diabetes. (Image courtesy of Katya Kadyshevskaya, The Scripps Research Institute) The three-dimensional (3-D) atomic structure of the human glucagon receptor has been identified by an international team of researchers carrying out

60

A Carbohydrate Recognition–Based Drug Delivery and Controlled Release System using Intraperitoneal Macrophages as a Cellular Vehicle  

Science Journals Connector (OSTI)

...fluorescence imaging system (FIS) with excitation...nm). For the detection of macrophages...for a cellular vehicle in a drug delivery system so as to control...controlled release system using intraperitoneal...as a cellular vehicle. | The lymphoid...

Yuzuru Ikehara; Toru Niwa; Le Biao; Sanae Kabata Ikehara; Norifumi Ohashi; Takeshi Kobayashi; Yoshitaka Shimizu; Naoya Kojima; and Hayao Nakanishi

2006-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Abstract #1561: RNA nanoparticle vaccines: combining drug inducible CD40 activation with CTL peptide delivery improves vaccine efficacy  

Science Journals Connector (OSTI)

...Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc...circulation. We have engineered a polymeric nanoparticle encapsulated curcumin formulation...bioavailability. We envisioned that nanoparticle-mediated drug delivery could be useful...

Alison McCormick; Jan Kemnade; David Spencer

2009-05-01T23:59:59.000Z

62

Oral Drug Absorption  

E-Print Network [OSTI]

properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

Yamashita, Shinji

2006-10-26T23:59:59.000Z

63

Computational analysis of biochemical networks for drug target identification and therapeutic intervention design  

E-Print Network [OSTI]

Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear ...

Paudel, Nirmala

2014-01-01T23:59:59.000Z

64

Antigen-specific blocking of immunological synapse formation using bifunctional peptide, Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes  

E-Print Network [OSTI]

Theranostics 2011, 1 http://www.thno.org 277 Theranostics 2011; 1:277-289 Research Paper Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes Prakash Manikwar1, Bimo A. Tejo1,2, Heather Shinogle3, David S... via a unique pathway Theranostics 2011, 1 http://www.thno.org 278 referred to as CAM-mediated endocytosis [10-13]. Ligands that bind to CAM can be used to selectively target drugs for intracellular delivery to immune cells expressing...

Manikwar, Prakash; Tejo, Bimo A.; Shinogle, Heather; Moore, David S.; Zimmerman, Tahl; Blanco, Francisco; Siahaan, Teruna J.

2011-05-01T23:59:59.000Z

65

Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats  

Science Journals Connector (OSTI)

...convection-enhanced drug delivery study in rats Liat Goldberg 1 Aharon Ocherashvilli 2...of the Ras oncogene in a 9L gliosarcoma rat model. The drug we used was salirasib...tumor growth rate in salirasib-treated rats relative to vehicle-treated rats as well...

Liat Goldberg; Aharon Ocherashvilli; Dianne Daniels; David Last; Zvi R. Cohen; Gregory Tamar; Yoel Kloog; Yael Mardor

2008-11-01T23:59:59.000Z

66

Identification of chemogenomic features from drug–target interaction networks using interpretable classifiers  

Science Journals Connector (OSTI)

......Supplementary Information: Datasets and all results are available...protein-coupled receptors (GPCRs) or nuclear receptors. The dataset consists of 4809 drug-target...2008). Target proteins in our dataset were associated with 876 PFAM......

Yasuo Tabei; Edouard Pauwels; Véronique Stoven; Kazuhiro Takemoto; Yoshihiro Yamanishi

2012-09-15T23:59:59.000Z

67

Novel drug delivery systems: Chitosan conjugates covalently attached to steroids with potential anticancer and agrochemical activity  

Science Journals Connector (OSTI)

Chitosan (CS) was linked to diosgenin monoesters with potential anticancer and agrochemical activity employing several methods (i.e. solid phase microwave assisted synthesis with carbodiimides activation, acyl chloride approach and homogeneous reaction with carbodiimides activation in aqueous solution). The steroid contents found by elemental analysis were between 5 and 33% (w/w) and was dependent on the nature of the employed linker and the steroid–CS conjugates preparation method. Linking was confirmed by FTIR spectroscopy. Differential scanning calorimetry studies are presented. In vitro release studies performed in water at different pH indicated a drug release dependence on the dicarboxylic acid employed as linker, the steroid content and the acidity of the solution. The obtained conjugates can be potentially applied as films, microspheres or gels for delivery of plant growth regulators in agriculture and anticancer drugs.

Javier Pérez Quiñones; Richard Szopko; Claudia Schmidt; Carlos Peniche Covas

2011-01-01T23:59:59.000Z

68

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs  

E-Print Network [OSTI]

theranostics Guizhi Zhua,b,c , Jing Zhenga,b , Erqun Songb,d , Michael Donovana , Kejing Zhangb , Chen LiueNTrs a promising targeted drug transport platform for cancer theranostics. self-assembly | DNA nanomedicines). A theranostic (4) platform with targeted and efficient drug transport would solve these problems, and, by its

Tan, Weihong

69

Synthesis, Processing and Solid State Excipient Interactions of Cucurbit[6]uril and Its Formulation into Tablets for Oral Drug Delivery  

Science Journals Connector (OSTI)

(15) Previously, CB[n]s have been shown to be excellent drug delivery vehicles for platinum-based anticancer drugs,(5, 16, 17) agricultural fungicides,(18) acetylchloinesterase inhibitors and cholines,(19, 20) antituberculosis drugs,(21) and anesthetics,(22) and as physical stabilizers for a range of other drugs, such as memantine, atenolol, glibenclamide and paracetamol. ... Simulated intestinal fluid (SIFsp) was made in accordance with the United States Pharmacopeia using 6.8 g of KH2PO4 and 0.89 g of NaOH in 1.0 L of water to obtain a buffer of pH 6.8. ...

Shonagh Walker; Rajdip Kaur; Fiona J. McInnes; Nial J. Wheate

2010-07-16T23:59:59.000Z

70

Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection  

SciTech Connect (OSTI)

The central theme of this dissertation is represented by the versatility of mesoporous silica nanomaterials in various applications such as catalysis and bio-applications, with main focus on biological applications of Mesoporous Silica Nanospheres (MSN). The metamorphosis that we impose to these materials from catalysis to sensing and to drug and gene delivery is detailed in this dissertation. First, we developed a synthetic method that can fine tune the amount of chemically accessible organic functional groups on the pores surface of MSN by exploiting electrostatic and size matching between the cationic alkylammonium head group of the cetyltrimethylammonium bromide (CTAB) surfactant and various anionic organoalkoxysilane precursors at the micelle-water interface in a base-catalyzed condensation reaction of silicate. Aiming nature imitation, we demonstrated the catalytic abilities of the MSNs, We utilized an ethylenediamine functional group for chelating Cu{sup 2+} as a catalytic functional group anchored inside the mesopores. Thus, a polyalkynylene-based conducting polymer (molecular wire) was synthesized within the Cu-functionalized MSNs silica catalyst. For sensing applications, we have synthesized a poly(lactic acid) coated mesoporous silica nanosphere (PLA-MSN) material that serves as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. We exploited the mesoporosity of MSNs for encapsulating pharmaceutical drugs. We examined bio-friendly capping molecules such as polyamidoamine dendrimers of generations G2 to G4, to prevent the drug leaching. Next, the drug delivery system employed MSNs loaded with Doxorubicin, an anticancer drug. The results demonstrated that these nano-Trojan horses have ability to deliver Doxorubicin to cancer cells and induce their death. Finally, to demonstrate the potential of MSN as an universal cellular transmembrane nanovehicle, we anchored positively charged dendrimers on the surface of MSN and utilize them to complex cationic DNA. The p-EGFP-CI gene-coated MSN nanocomposite was able to transfect cancer cell lines, such as human HeLa and CHO cancer cell lines. The gene carrier ability of MSNs was further proved by transfecting primary cells and cotransfecting of two different genes in cancer cell lines. In sum, MSN are versatile partners in several types of applications.

Daniela Rodica Radu

2005-12-19T23:59:59.000Z

71

Structure-based drug mechanism study and inhibitor design targeting tuberculosis  

E-Print Network [OSTI]

, ethionamide and prothionamide all target InhA, which validates the enzyme as a superb drug target. A structure-based approach was adopted to design new inhibitors targeting InhA, using triclosan as the scaffold. Guided by the InhA-inhibitor complex structures...

Wang, Feng

2009-05-15T23:59:59.000Z

72

Evaluation of Dysprosia Aerogels as Drug Delivery Systems: A Comparative Study with Random and Ordered Mesoporous Silicas  

Science Journals Connector (OSTI)

The high drug uptake and slow release from dysprosia aerogels, in combination with their low toxicity, strong paramagnetism, and the possibility for neutron activation render those materials attractive multifunctional vehicles for site-specific drug delivery. ... X-rdm-DyOx aerogel samples (1 mg) were incubated with fresh human whole blood (30 ?L, Oklahoma Blood Institute, Oklahoma City, OK) for 24 h at room temperature. ...

Abhishek Bang; Anand G. Sadekar; Clayton Buback; Brice Curtin; Selin Acar; Damir Kolasinac; Wei Yin; David A. Rubenstein; Hongbing Lu; Nicholas Leventis; Chariklia Sotiriou-Leventis

2014-03-25T23:59:59.000Z

73

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics  

Science Journals Connector (OSTI)

...transport of molecular drugs in cancer theranostics 10.1073/pnas.1220817110 Guizhi...drug transport platform for cancer theranostics. Although chemotherapeutic drugs are widely used in...promising TDT platform for targeted cancer theranostics. Results and Discussion Construction...

Guizhi Zhu; Jing Zheng; Erqun Song; Michael Donovan; Kejing Zhang; Chen Liu; Weihong Tan

2013-01-01T23:59:59.000Z

74

Multiple chemical scaffolds inhibit a promising Leishmania drug target  

Science Journals Connector (OSTI)

The need for an effective oral therapy for leishmaniasis is addressed through the study of the target N-myristoyltransferase from Leishmania major.

Walkinshaw, M.

2014-06-24T23:59:59.000Z

75

Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O6-Benzylguanine to Brain Tumors  

Science Journals Connector (OSTI)

Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O6-Benzylguanine to Brain Tumors ... In vivo, CED of NPCP-BG-CTX produced an excellent volume of distribution (Vd) within the brain of mice bearing orthotopic human primary GBM xenografts. ...

Zachary R. Stephen; Forrest M. Kievit; Omid Veiseh; Peter A. Chiarelli; Chen Fang; Kui Wang; Shelby J. Hatzinger; Richard G. Ellenbogen; John R. Silber; Miqin Zhang

2014-09-23T23:59:59.000Z

76

In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer Rajiv Kumar*, Apurva Kulkarni, Dattatri K Nagesha, Srinivas Sridhar  

E-Print Network [OSTI]

In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer Rajiv decade engineered nanoplatforms have seen a momentous progress in developing a multimodal theranostic and application of theranostic phospholipid based polymeric micelles for optical fluorescence imaging

Sridhar, Srinivas

77

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen...  

Broader source: Energy.gov (indexed) [DOE]

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

78

1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds  

E-Print Network [OSTI]

proteins including enzymes, ion channels, GPCRs and nuclear receptors. However, current drug and nuclear receptors [5]. Publicly available databases have been built and maintained, such as KEGG BRITE [6 using chemical and interaction information about known compounds in the dataset. The WNN method can

Marchiori, Elena

79

Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles  

SciTech Connect (OSTI)

This research project compares laboratory-measured fuel economy of a medium-duty diesel powered hydraulic hybrid vehicle drivetrain to both a conventional diesel drivetrain and a conventional gasoline drivetrain in a typical commercial parcel delivery application. Vehicles in this study included a model year 2012 Freightliner P100H hybrid compared to a 2012 conventional gasoline P100 and a 2012 conventional diesel parcel delivery van of similar specifications. Drive cycle analysis of 484 days of hybrid parcel delivery van commercial operation from multiple vehicles was used to select three standard laboratory drive cycles as well as to create a custom representative cycle. These four cycles encompass and bracket the range of real world in-use data observed in Baltimore United Parcel Service operations. The NY Composite cycle, the City Suburban Heavy Vehicle Cycle cycle, and the California Air Resources Board Heavy Heavy-Duty Diesel Truck (HHDDT) cycle as well as a custom Baltimore parcel delivery cycle were tested at the National Renewable Energy Laboratory's Renewable Fuels and Lubricants Laboratory. Fuel consumption was measured and analyzed for all three vehicles. Vehicle laboratory results are compared on the basis of fuel economy. The hydraulic hybrid parcel delivery van demonstrated 19%-52% better fuel economy than the conventional diesel parcel delivery van and 30%-56% better fuel economy than the conventional gasoline parcel delivery van on cycles other than the highway-oriented HHDDT cycle.

Lammert, M. P.; Burton, J.; Sindler, P.; Duran, A.

2014-10-01T23:59:59.000Z

80

Development of lymphatic drug delivery platforms for the treatment of carcinomas  

E-Print Network [OSTI]

, and evaluated in preclinical rodent models. The route of drug administration along with the controlled release of the drug from the platforms, both play an important role in improving the biopharmaceutical properties of these conjugates. This is demonstrated...

Cai, Shuang

2011-05-31T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Chapter 4 - Regulators of G Protein Signaling Proteins as Targets for Drug Discovery  

Science Journals Connector (OSTI)

Signaling via G-protein-coupled receptors (GPCRs) is central for the function of biological systems. Many clinically used drugs target \\{GPCRs\\} directly or target molecules involved in GPCR signaling. As an alternative to targeting receptors directly, one could modulate signaling cascades downstream of receptor activation. In recent years, there has been substantial interest in a family of proteins called regulators of G protein signaling (RGS) proteins. They modulate GPCR signaling by accelerating GTP hydrolysis on active G? subunits, thereby reducing the amplitude and duration of signaling. Modulating RGS activity would be a useful strategy to control GPCR signaling. An RGS inhibitor would be expected to enhance GPCR signaling and could do so in a tissue- or pathway-specific manner. Apart from the central GAP (GTPase accelerating protein) activity, many RGS proteins also have other functions like regulating protein–protein interactions, subcellular localization of signaling molecules, and protein translation. It is clear that these proteins serve important functions in a number of physiological and pathophysiological processes, and they are emerging as potential drug targets. This chapter gives an overview of what is currently known about biological functions of RGS proteins based on in vivo and in vitro data. We also summarize the current status in targeting RGS proteins in drug discovery.

Benita Sjögren; Levi L. Blazer; Richard R. Neubig

2010-01-01T23:59:59.000Z

82

E-Print Network 3.0 - anticancer drug delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Chemistry, University of Utah Collection: Chemistry 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

83

Optimal periodic control of a drug delivery system Subbarao Varigonda 1  

E-Print Network [OSTI]

drug infusion strategies for maximizing a time averaged measure of drug effect are investigated infusion provides a locally improved average effect compared to steady infusion are characterized using 1­2 hr), as steady infusion leads to nearly complete sup- pression of gonadal function [24

Georgiou, Tryphon T.

84

Abstract 4469: An evaluation of the role of mucin in nano drug delivery  

Science Journals Connector (OSTI)

...photo-immunotherapy (PIT) can accommodate massive nano-sized reagents deep into tumors. Hisataka...permeability leading to 12- to 25-fold enhanced nano-particle delivery into cancer tissue...EPR). Of particular interest is that nano-sized reagents including macromolecules...

Musaed A. Alkholief and Robert Campbell

2014-10-01T23:59:59.000Z

85

10 - Regulator of G Protein Signaling Proteins as Drug Targets: Current State and Future Possibilities  

Science Journals Connector (OSTI)

Abstract Regulators of G protein signaling (RGS) proteins have emerged in the past two decades as novel drug targets in many areas of research. Their importance in regulating signaling via G protein-coupled receptors has become evident as numerous studies have been published on the structure and function of RGS proteins. A number of genetic models have also been developed, demonstrating the potential clinical importance of RGS proteins in various disease states, including central nervous system disorders, cardiovascular disease, diabetes, and several types of cancer. Apart from their classical mechanism of action as GTPase-activating proteins (GAPs), RGS proteins can also serve other noncanonical functions. This opens up a new approach to targeting RGS proteins in drug discovery as the view on the function of these proteins is constantly evolving. This chapter summarizes the latest development in RGS protein drug discovery with special emphasis on noncanonical functions and regulatory mechanisms of RGS protein expression. As more reports are being published on this group of proteins, it is becoming clear that modulation of GAP activity might not be the only way to therapeutically target RGS proteins.

Benita Sjögren

2011-01-01T23:59:59.000Z

86

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network [OSTI]

D. F. , Kahl, S. B. , Bjornstad, K. A. , Bauer, W. F. ,L. , Blakely, E. A. , Bjornstad, K. A. , Deen, D. F. ,Blakely 2 , Kathleen A. Bjornstad 2 , Xiao Shu 3 ,Thomas F.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

87

Genome-Free Viral Capsids for Targeted Drug Delivery to Breast Cancer  

E-Print Network [OSTI]

Water (ddH 2 O) used in biological procedures or as a reaction solvent was deionized using a NANOpure TM purification system (Water (ddH 2 O) used in biologi- cal procedures or as a reaction solvent was deionized using a NANOpure TM purification system (

Wu, Wesley

2012-01-01T23:59:59.000Z

88

MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells  

E-Print Network [OSTI]

imaging; theranostic nanomedicine; doxorubicin; Rv 6 integrin; superparamagnetic iron oxide; lung cancer

Gao, Jinming

89

Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review  

Science Journals Connector (OSTI)

...defined multivalent inhibitors of the adherence...Chemical modification of chitosan. 3. Hyperbranched chitosan-sialic acid dendrimer...of dendrimerized chitosan-sialic acid hybrid...multivalent ligands and inhibitors. Angew. Chem...

2012-01-01T23:59:59.000Z

90

NEST Scientific Report 2007-2009 Nanotechnology for intracellular delivery and targeting of drugs, nanoreporters  

E-Print Network [OSTI]

attention on the arginine-rich motif derived from the HIV transactivator of transcription protein Tat (residues 47-57 YGRKKRRQRRR of HIV-Tat protein full length). In order to elucidate the entrance pathway of Tat arginin-rich peptides and provides further information on the controversial mechanism of its

Abbondandolo, Alberto

91

Synthesis and Characterization of Lipid-Polymer Hybrid Nanoparticles for Combinatorial Drug Delivery  

E-Print Network [OSTI]

that has versatile functionality, good serum stability, circulates in the body long enough to reach the targeting tissues, and is biocompatible. A promising formulation platform that embodies these features is the lipid-polymer hybrid nanoparticles...

Stavropoulos, Kathy

2011-08-31T23:59:59.000Z

92

Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale  

Science Journals Connector (OSTI)

...tumors. Fourth, the results highlight the increasing use/abuse of stable disease as a measure of drug efficacy. As discussed...1995;332:1004-14. 25. Drugs.com [homepage on the Internet].Paclitaxel. Available from: http://www.drugs...

Edina Komlodi-Pasztor; Dan L. Sackett; and Antonio Tito Fojo

2012-01-01T23:59:59.000Z

93

Preparation, Characterization, and Preliminary Application of Fibrinogen-Coated Olive Oil Droplets for the Targeted Delivery of Docetaxel to Solid Malignancies  

Science Journals Connector (OSTI)

...of Fibrinogen-Coated Olive Oil Droplets for the Targeted Delivery...Micronized droplets of olive oil loaded with docetaxel (1.0...The area of the absorbance peak that was centered about a retention...Vitro of Docetaxel-Loaded Olive Oil Droplets. We prepared and characterized...

Abhijeet S. Jakate; Charity M. Einhaus; Ashley P. DeAnglis; Gregory S. Retzinger; and Pankaj B. Desai

2003-11-01T23:59:59.000Z

94

Unibody core–shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging  

Science Journals Connector (OSTI)

Abstract Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core–shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic \\{NPs\\} (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1 = 0.9 and 14.5 mm?1 s?1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic \\{NPs\\} with Gd-conjugation and Dox doping.

Lin-Chen Ho; Chao-Hsiung Hsu; Chung-Mao Ou; Chia-Wei Wang; Tsang-Pai Liu; Lian-Pin Hwang; Yung-Ya Lin; Huan-Tsung Chang

2015-01-01T23:59:59.000Z

95

Non-metallic nanomaterials in cancer theranostics: a review of silica- and carbon-based drug delivery systems  

Science Journals Connector (OSTI)

The rapid development in nanomaterials has brought great opportunities to cancer theranostics, which aims to combine diagnostics and therapy for cancer treatment and thereby improve the healthcare of patients. In this review we focus on the recent progress of several cancer theranostic strategies using mesoporous silica nanoparticles and carbon-based nanomaterials. Silicon and carbon are both group IV elements; they have been the most abundant and significant non-metallic substances in human life. Their intrinsic physical/chemical properties are of critical importance in the fabrication of multifunctional drug delivery systems. Responsive nanocarriers constructed using these nanomaterials have been promising in cancer-specific theranostics during the past decade. In all cases, either a controlled texture or the chemical functionalization is coupled with adaptive properties, such as pH-, light-, redox- and magnetic field- triggered responses. Several studies in cells and mice models have implied their underlying therapeutic efficacy; however, detailed and long-term in vivo clinical evaluations are certainly required to make these bench-made materials compatible in real bedside circumstances.

Yu-Cheng Chen; Xin-Chun Huang; Yun-Ling Luo; Yung-Chen Chang; You-Zung Hsieh; Hsin-Yun Hsu

2013-01-01T23:59:59.000Z

96

High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics  

SciTech Connect (OSTI)

Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

2014-01-01T23:59:59.000Z

97

A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products  

Science Journals Connector (OSTI)

Gillman, P. K. ( 2007) Tricyclic antidepressant pharmacology and therapeutic drug interactions updated Br. ... Gillman, P. K. ...

Anne Mai Wassermann; Eugen Lounkine; Laszlo Urban; Steven Whitebread; Shanni Chen; Kevin Hughes; Hongqiu Guo; Elena Kutlina; Alexander Fekete; Martin Klumpp; Meir Glick

2014-05-06T23:59:59.000Z

98

A simple system for remote processing and delivery of H{sub 2}[{sup 15}O] produced from a N{sub 2}/H{sub 2} target  

SciTech Connect (OSTI)

The N{sub 2} + H{sub 2} target can produce more than enough H{sub 2}[{sup 15}O] to meet the demands of any PET imaging facility. We have shown that the radiotracer can be transported across 300 feet of tubing without significant loss of activity, using fast tows of target gas. Thus, there is no need to maintain an extraneous chemical Processing station at the PET imaging facility. A simple remotely operated system is reported that performs the three step operation for H{sub 2}[{sup 15}O] delivery at the PET imaging facility: collection of the radiotracer in water; removal of ammonia from the preparation and delivery of the radiotracer to the injection syringe. The system can process and make available for injection 100 mCi of H{sub 2}[{sup 15}O]. The machine is easily prepped for subsequent deliveries. So that additional doses of radiotracer can be made available within 12 minutes. A general syringe loading device with remote hydraulic injector is that is compatible for use with any H{sub 2}[{sup 15}O] radiotracer processing station. The device allows for direct measurement of syringe dose while filling, and for easy, as well as safe transfer of the injection syringe assembly to a delivery cart that houses the remote hydraulic injector. The injection syringe is never handled directly during transport nor during injection except, to connect it to the intravenous line, thus minimizing radiation exposure to personnel.

Ferrieri, R.A.; Alexoff, D.L.; Schlyer, D.L.; Wolf, A.P.

1993-12-31T23:59:59.000Z

99

Nanoparticle-Aptamer Bioconjugates: A New Approach for Targeting Prostate Cancer Cells  

Science Journals Connector (OSTI)

Advances in Brief Nanoparticle-Aptamer BioconjugatesA New Approach...nontargeted cells. Next, we generated nanoparticle-aptamer bioconjugates with RNA...of targeted drug delivery with nanoparticle-aptamer bioconjugates. Introduction...

Omid C. Farokhzad; Sangyong Jon; Ali Khademhosseini; Thanh-Nga T. Tran; David A. LaVan; Robert Langer

2004-11-01T23:59:59.000Z

100

Remote processing, delivery and injection of H2[15O] produced from a N2/H2 gas target using a simple and compact apparatus  

Science Journals Connector (OSTI)

We report here a simple apparatus for remote trapping and processing of H2[15O] produced from the N2/H2 target. The system performs a three step operation for H2[15O] delivery at the PET imaging facility which includes the following: (i) collecting the radiotracer in sterile water; (ii) adjusting preparation pH through removal of radiolytically produced ammonia, while at the same time adjusting solution isotonicity; and (iii) delivery of the radiotracer preparation to the injection syringe in a sterile and pyrogen-free form suitable for human studies. The processing apparatus is simple, can be remotely operated and fits inside a Capintec Dose Monitoring Chamber for direct measurement of accumulated radioactivity. Using this system, 300 mCi of H2[15O] (15 ?A of 8 MeV D+ on target) is transferred from target through 120 m × 3.18 mm o.d. Impolene tubing to yield 100 mCi of H2[15O] which is isotonic, neutral and suitable for human studies. A remote hydraulically driven system for i.v. injection of the H2[15O] is also described. The device allows for direct measurement of syringe dose while filling, and for easy, as well as safe transport of the injection syringe assembly to the patient's bedside via a shielded delivery cart. This cart houses a hydraulic piston that allows the physician to “manually” inject the radiotracer without directly handling the syringe.

Richard A. Ferrieri; David L. Alexoff; David J. Schlyer; Alfred P. Wolf

1994-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Gaseous Hydrogen Delivery Breakout- Strategic Directions for Hydrogen Delivery Workshop  

Broader source: Energy.gov [DOE]

Targets, barriers and research and development priorities for gaseous delivery of hydrogen through hydrogen and natural gas pipelines.

102

Microspheres for Drug Delivery  

Science Journals Connector (OSTI)

With advances in biotechnology, genomics, and combinatorial chemistry, a wide variety of new, more potent and specific therapeutics are being created. Because of common problems such as low solubility, high po...

Kyekyoon Kevin Kim; Daniel W. Pack

2006-01-01T23:59:59.000Z

103

E-Print Network 3.0 - antibiotic drug targets Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

aureus1 Summary: or lack the target of the antibiotic. b | Multidrug resistance efflux pumps. These pumps secrete... modify the target protein, for example by disabling the...

104

Articulating feedstock delivery device  

DOE Patents [OSTI]

A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

Jordan, Kevin

2013-11-05T23:59:59.000Z

105

E-Print Network 3.0 - anticancer drug targets Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Toronto Collection: Biology and Medicine 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

106

Solid lipid nanoparticle and nanoparticle lipid carrier for controlled drug delivery – a review of state of art and recent advances  

Science Journals Connector (OSTI)

It is estimated that nearly 40% of new drug molecules are suffering from poor water solubility, insufficient bioavailability, fluctuating plasma levels or high food dependency. Major efforts have been spent for the development of customised drug carriers to overcome the disappointing in vivo fates of the drug. Both the SLN and NLC are attractive carriers for topical cosmetic and pharmaceutical products. Solid lipid nanoparticles (SLNs) introduced as an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. This paper reviews the present state of the art regarding production techniques for SLN, drug incorporation, loading capacity and drug release, especially focusing on drug release mechanisms. The potential of SLN to be exploited for the different administration routes is highlighted and also reviews about SLN and NLC's stability, toxicity, pharmacokinetic profile, application and its future perspectives.

R. Thiruganesh; S.K. Uma Devi

2010-01-01T23:59:59.000Z

107

Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework  

Science Journals Connector (OSTI)

......channels, GPCRs and nuclear receptors. Our comprehensively...Supplementary information: Datasets and all prediction results...receptors (GPCRs) and nuclear receptors. Owing to...channels, GPCRs and nuclear receptors. Our comprehensively...genomic drug discovery. Datasets and all prediction results......

Yoshihiro Yamanishi; Masaaki Kotera; Minoru Kanehisa; Susumu Goto

2010-06-15T23:59:59.000Z

108

Identification of novel synergistic targets RACK-1 and galectin-1 for rational drug combinations with PI3 Kinase inhibitors using siRNA synthetic lethality screening.  

Science Journals Connector (OSTI)

...Proffered Abstracts AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA Identification of novel synergistic targets RACK-1 and galectin-1 for rational drug combinations with PI3 Kinase inhibitors using siRNA synthetic lethality screening. Yong...

Yong- Kim; Ningyi Tiao; Tiffany Lafortune; Ta Jen Liu; Garth Powis; Alfred WK Yung; Dimpy Koul

2008-05-01T23:59:59.000Z

109

IN VITRO AND IN VIVO EVALUATION OF NOVEL I-DOMAIN CONJUGATES FOR DRUG TARGETING TO IMMUNE CELLS AND SUPPRESSION OF EAE IN MICE  

E-Print Network [OSTI]

The long-term objective of this project is to utilize the I-domain of leukocyte function associated antigen-1 (LFA-1) to target antigenic peptides and drugs to intercellular adhesion molecule-1 (ICAM-1) expressed on the ...

Manikwar, Prakash

2010-06-23T23:59:59.000Z

110

Nanoparticle Agglomeration via Ionic Colloidal Destabilization as a Novel Approach to Dry Powder Formulations for Pulmonary Drug Delivery  

E-Print Network [OSTI]

Efficient administration of poorly water soluble drugs represents a leading challenge in pulmonary medicine. This route of administration has been used for steroidal treatments for some time, but with room for advancement. New inhalable medicines...

Plumley, Carl Joseph

2008-08-05T23:59:59.000Z

111

Drug–target interaction prediction through domain-tuned network-based inference  

Science Journals Connector (OSTI)

......measure of sparsity Dataset Structures Targets...95 635 0.0299 Nuclear receptors 54 26...channels, GPCRs, and nuclear receptor datasets using the top-30...built on the four datasets (enzymes, ion channels, GPCRs and nuclear receptors) Table......

Salvatore Alaimo; Alfredo Pulvirenti; Rosalba Giugno; Alfredo Ferro

2013-08-15T23:59:59.000Z

112

Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles  

Science Journals Connector (OSTI)

...a 5% CO2-95% air atmosphere. Prior to their use...a 5% CO2-95% air atmosphere. Immunofluorescence...a 5% CO2-95% air atmosphere. Macrophages on coverslips...temperature to stain plasma membranes, washed with...areas at a speed of 400 MHz and a resolution of...

Daniel L. Clemens; Bai-Yu Lee; Min Xue; Courtney R. Thomas; Huan Meng; Daniel Ferris; Andre E. Nel; Jeffrey I. Zink; Marcus A. Horwitz

2012-02-21T23:59:59.000Z

113

Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles  

Science Journals Connector (OSTI)

...a 5% CO2-95% air atmosphere. Immunofluorescence...a 5% CO2-95% air atmosphere. Macrophages on coverslips...temperature to stain plasma membranes, washed with...areas at a speed of 400 MHz and a resolution of 1...Published ahead of print 21 February 2012 ACKNOWLEDGMENTS...

Daniel L. Clemens; Bai-Yu Lee; Min Xue; Courtney R. Thomas; Huan Meng; Daniel Ferris; Andre E. Nel; Jeffrey I. Zink; Marcus A. Horwitz

2012-02-21T23:59:59.000Z

114

Anti-HER2 Cationic Immunoemulsion as a Potential Targeted Drug Delivery System for the Treatment of Prostate Cancer  

Science Journals Connector (OSTI)

...and response to treatment with a HER2-directed...single agent for the treatment of these patients...concentrations in oil/water nanoemulsions will...Germany) at 25C using water as the solvent...unconjugated mAbs by dialysis using a polyvinylidene...for transmission electron microscopy (TEM...

Danny Goldstein; Ofer Gofrit; Abraham Nyska; and Simon Benita

2007-01-01T23:59:59.000Z

115

Anti-tumor effect and immuno-toxicity of target-specific drug delivery system: Doxorubicin-encapsulated nano particle  

Science Journals Connector (OSTI)

...Abstract #788: Long-term exposure to Nano-TiO2 promotes genomic instability and...Denver, CO Titanium dioxide (TiO2) nano-particles (100 nm in diameter) have...However, recent studies have shown that TiO2 nano-particles (nano-TiO2) induce cytotoxicity...

Hyunah Lee; Eui Jin Kim; Jeong-Jun Yu; Soo-Won Shu; Young Hyeh Ko; Jinny Park; Keun Chil Park; Hong Ghi Lee

2004-04-01T23:59:59.000Z

116

Predicting drug–target interactions from chemical and genomic kernels using Bayesian matrix factorization  

Science Journals Connector (OSTI)

......provide visualizations on Nuclear Receptor dataset due to its small network...proteins obtained by KBMF2K on Nuclear Receptor dataset with (A) held-out drug...dimensionality and nu = 0. On Nuclear Receptor dataset, we do not see any effect......

Mehmet Gönen

2012-09-15T23:59:59.000Z

117

Perspective on the Pipeline of Drugs Being Developed with Modulation of DNA Damage as a Target  

Science Journals Connector (OSTI)

...When considering the pipeline of novel agents that...which blocking a DNA repair pathway was the primary...RD D'Andrea AD. DNA repair pathways in clinical...Perspective on the pipeline of drugs being developed...various elements of the DNA repair pathways have entered...

Ruth Plummer

2010-09-15T23:59:59.000Z

118

Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents  

Science Journals Connector (OSTI)

...2001 ) Adv. Drug Deliv. Rev. 47 , 251 -276. 11311995 13 Shaw, J. M., Shaw, K. V., Yanovich, S., Iwanik, M., Futch, W. S., Rosowsky, A. & Schook, L. B. ( 1987 ) Ann. N.Y. Acad. Sci. 507 , 252 -271. 3442366 14 Versluis, A...

Gang Zheng; Juan Chen; Hui Li; Jerry D. Glickson

2005-01-01T23:59:59.000Z

119

Membrane protein kit may lead to better targeted drugs | Argonne National  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne scientists received an R&D100 Award for using Rhodobacter to develop a new system for growing membrane proteins used in drug discovery research. Image by Sheng-Wen Chui, University of Oxford. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne

120

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis  

Science Journals Connector (OSTI)

Utilizing a chemical genomics-based screening platform referred to as the Candida albicans fitness test (CaFT), we have identified novel inhibitors of Gwt1 and a second enzyme in the glycosylphosphatidylinositol (GPI) cell wall anchor pathway, Mcd4. ... The response of each heterozygote to the effects of the compound is then appraised by calculating a normalized Z score, with a positive value indicating hypersensitivity and a negative value reflecting resistance (or hyposensitivity) to the tested compound. ... MCD4 heterozygote hypersensitivity to M743 is directly demonstrated by serial dilution spot tests on drug-containing plates (Figure S2) and further corroborated by genetic knockdown of MCD4 expression using a conditional mutant under the control of a tetracycline-regulatable promoter (Figure S4). ...

Paul A. Mann; Catherine A. McLellan; Sandra Koseoglu; Qian Si; Elena Kuzmin; Amy Flattery; Guy Harris; Xinwei Sher; Nicholas Murgolo; Hao Wang; Kristine Devito; Nuria de Pedro; Olga Genilloud; Jennifer Nielsen Kahn; Bo Jiang; Michael Costanzo; Charlie Boone; Charles G. Garlisi; Susan Lindquist; Terry Roemer

2014-12-05T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Target  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Lifetime measurements in Lifetime measurements in inverse kinematics Coulex Target e.g. C Stopper e.g. Cu Beam X X * C Si-Det. Yale Plunger 120 Te at 300 MeV Plunger foils Si-Detector Compton-suppressed Clover detectors (8) 50% Coulomb- barrier )] ( exp[ 1 ) ( 0 d d d P - - - = λ Probability of emitting gamma-ray while in-flight: From data: ) ( ) ( ) ( ) ( ) ( d I d I d P total shifted γ γ = where ) ( ) ( γ γ γ γ θ ε W E N I = Lifetime analysis For example: Valence proton symmetry Data from NNDC, WNSL ( 120 Te), NBI group ( 116 Te), Cologne ( 114 Te) B(E2)up [e 2 b 2 ] N A.A. Pasternak et al., EPJA 13, 435 (2002) O. Möller et al., PRC 71, 064324 (2005) Study deviations from (collective) expectations -> needs a fast and easy way to obtain data -> inverse RDDS well suited! Important in inverse kinematics: Deorientation F I J Large v/c => except for relativistic

122

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

123

Hydrogen Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mark Paster Energy Efficiency and Renewable Energy Hydrogen, Fuel Cells and Infrastructure Technology Program Hydrogen Production and Delivery Team Hydrogen Delivery Goal Hydrogen Delivery Goal Liquid H 2 & Chem. Carriers Gaseous Pipeline Truck Hydrides Liquid H 2 - Truck - Rail Other Carriers Onsite reforming Develop Develop hydrogen fuel hydrogen fuel delivery delivery technologies that technologies that enable the introduction and enable the introduction and long long - - term viability of term viability of hydrogen as an energy hydrogen as an energy carrier for transportation carrier for transportation and stationary power. and stationary power. Delivery Options * End Game - Pipelines - Other as needed * Breakthrough Hydrogen Carriers * Truck: HP Gas & Liquid Hydrogen

124

Multi-functional Bio-synthetic Hybrid Nanostructures for Enhanced Cellular Uptake, Endosomal Escape and Targeted Delivery Toward Diagnostics and Therapeutics  

E-Print Network [OSTI]

-like nanoparticles (SCKs) that are self assembled from amphiphilic block copolymers into polymeric micelles followed by crosslinking selectively throughout the shell domain have been investigated as theranostic agents for the delivery of nucleic acids...

Shrestha, Ritu 1984-

2012-09-26T23:59:59.000Z

125

Liguid and Solid Carriers Group- Strategic Directions for Hydrogen Delivery Workshop  

Broader source: Energy.gov [DOE]

Targets, barriers and research and development priorities for solid and liquid hydrogen storage and delivery materials.

126

Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy  

E-Print Network [OSTI]

-nanomaterial-based therapeutic strategies have been widely introduced into drug delivery and cancer theranostics, challenges

Tan, Weihong

127

Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gaseous Hydrogen Gaseous Hydrogen Delivery Breakout Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Breakout Session Name Targets/Objectives More work is needed to better define delivery target metrics Assumptions about targets for costs and energy efficiency need to be qualified Technology improvements likely to lower costs, but may not have major impact on total cost A significant impact on cost would come through permitting policy changes, e.g., use of public land Breakout Session Name Priority Barriers System Issues: need to assess delivery options in context of total system Materials: corrosion, H2 permeability Construction: welding, joining Maintenance and Operation: leak detection Pipeline Safety: odorants, flame visibility

128

Abstract 2986: Novel vascular targeting strategy using pegylated liposomal doxorubicin to increase drug accumulation to tumor site and therapeutic efficacy  

Science Journals Connector (OSTI)

...and therapeutic efficacy Kenji Yokoi Tomonori Tanei Yuki Saito Mauro Ferrari Houston Methodist Research Institute, Houston, TX...Citation Format: Kenji Yokoi, Tomonori Tanei, Yuki Saito, Mauro Ferrari. Novel vascular targeting strategy using pegylated...

Kenji Yokoi; Tomonori Tanei; Yuki Saito; Mauro Ferrari

2014-10-01T23:59:59.000Z

129

Self-assembled pentablock copolymers for selective and sustained gene delivery  

SciTech Connect (OSTI)

The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

Zhang, Bingqi

2011-05-15T23:59:59.000Z

130

New Computational Approaches for NMR-based Drug Design: A Protocol for Ligand Docking to Flexible Target Sites  

SciTech Connect (OSTI)

NMR-based drug design has met with some success in the last decade, as illustrated in numerous instances by Fesik's ''ligand screening by NMR'' approach. Ongoing efforts to generalize this success have led us to the development of a new paradigm in which quantitative computational approaches are being integrated with NMR derived data and biological assays. The key component of this work is the inclusion of the intrinsic dynamic quality of NMR structures in theoretical models and its use in docking. A new computational protocol is introduced here, designed to dock small molecule ligands to flexible proteins derived from NMR structures. The algorithm makes use of a combination of simulated annealing monte carlo simulations (SA/MC) and a mean field potential informed by the NMR data. The new protocol is illustrated in the context of an ongoing project aimed at developing new selective inhibitors for the PCAF bromodomains that interact with HIV Tat.

Gracia, Luis; Speidel, Joshua A. [Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York NY 10028 (United States); Weinstein, Harel [Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York NY 10028 (United States); HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York NY 10028 (United States)

2006-08-24T23:59:59.000Z

131

In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine  

Science Journals Connector (OSTI)

The recent advances in nanotechnology have a great potential to improve the ... wavelength. Future innovation in cancer imaging by nanotechnology and novel measurement technology will provide great ... in basic m...

Motohiro Takeda; Hiroshi Tada; Hideo Higuchi; Yoshio Kobayashi…

2008-04-01T23:59:59.000Z

132

Self-Assembling Doxorubicin–Tocopherol Succinate Prodrug as a New Drug Delivery System: Synthesis, Characterization, and in Vitro and in Vivo Anticancer Activity  

Science Journals Connector (OSTI)

Gong, X., Moghaddam, M. J., Sagnella, S. M., Conn, C. E., Danon, S. J., Waddington, L. J., and Drummond, C. J. ( 2011) Lyotropic liquid crystalline self-assembly material behavior and nanoparticulate dispersions of a phytanyl pro-drug analogue of capecitabine-a chemotherapy agent ACS Appl. ... Gong, Xiaojuan; Moghaddam, Minoo J.; Sagnella, Sharon M.; Conn, Charlotte E.; Danon, Stephen J.; Waddington, Lynne J.; Drummond, Calum J. ...

Nicolas Duhem; Fabienne Danhier; Vincent Pourcelle; Jean-Marc Schumers; Olivier Bertrand; Cécile S. LeDuff; Stephanie Hoeppener; Ulrich S. Schubert; Jean-François Gohy; Jacqueline Marchand-Brynaert; Véronique Préat

2013-12-11T23:59:59.000Z

133

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydrogen Hydrogen Delivery Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Main Themes/Caveats Will be challenging (if not impossible) to meet the 2010 cost target with today's technology Without significant growth in product demand, progress will likely be slow even with incremental technology Group a little light on technical expertise, but feel captured main ideas required Less "weeding" of ideas, but more divergent thinking Targets/Objectives 2003 Status: $1.11/kg May be a bit lower than actual costs Baseline needs to be revisited 2005 Target: $1.01/kg Technically (10% improvement) could be met, but unlikely demand drivers will be present to encourage meeting target Likely no plant will be built in 2005

134

Bone marrow endothelium-targeted therapeutics for metastatic breast cancer  

Science Journals Connector (OSTI)

Abstract Effective treatment of cancer metastasis to the bone relies on bone marrow drug accumulation. The surface proteins in the bone marrow vascular endothelium provide docking sites for targeted drug delivery. We have developed a thioaptamer that specifically binds to E-selectin that is overexpressed in the vasculature of tumor and inflammatory tissues. In this study, we tested targeted delivery of therapeutic siRNA loaded in the E-selectin thioaptamer-conjugated multistage vector (ESTA-MSV) drug carrier to bone marrow for the treatment of breast cancer bone metastasis. We evaluated tumor type- and tumor growth stage-dependent targeting in mice bearing metastatic breast cancer in the bone, and carried out studies to identify factors that determine targeting efficiency. In a subsequent study, we delivered siRNA to knock down expression of the human STAT3 gene in murine xenograft models of human MDA-MB-231 breast tumor, and assessed therapeutic efficacy. Our studies revealed that the CD31+E-selectin+ population accounted for 20.8%, 26.4% and 29.9% of total endothelial cells respectively inside the femur of mice bearing early, middle and late stage metastatic MDA-MB-231 tumors. In comparison, the double positive cells remained at a basal level in mice with early stage MCF-7 tumors, and jumped to 23.9% and 28.2% when tumor growth progressed to middle and late stages. Accumulation of ESTA-MSV inside the bone marrow correlated with the E-selectin expression pattern. There was up to 5-fold enrichment of the targeted MSV in the bone marrow of mice bearing early or late stage MDA-MB-231 tumors and of mice with late stage, but not early stage, MCF-7 tumors. Targeted delivery of STAT3 siRNA in ESTA-MSV resulted in knockdown of STAT3 expression in 48.7% of cancer cells inside the bone marrow. Weekly systemic administration of ESTA-MSV/STAT3 siRNA significantly extended survival of mice with MDA-MB-231 bone metastasis. In conclusion, targeting the overexpressed E-selectin provides an effective approach for tissue-specific drug delivery to the bone marrow. Tumor growth in the bone can be effectively inhibited by blockage of the STAT3 signaling.

Junhua Mai; Yi Huang; Chaofeng Mu; Guodong Zhang; Rong Xu; Xiaojing Guo; Xiaojun Xia; David E. Volk; Ganesh L. Lokesh; Varatharasa Thiviyanathan; David G. Gorenstein; Xuewu Liu; Mauro Ferrari; Haifa Shen

2014-01-01T23:59:59.000Z

135

E-Print Network 3.0 - aptamer-targeted cell-specific rna Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nanovectors for Targeted Summary: -functionalized nanovectors are a prom- ising class of targeted delivery vehicles. Both peptide- and aptamer-targeting ligands......

136

Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport  

E-Print Network [OSTI]

Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

Tang, Hua, 1972-

2002-01-01T23:59:59.000Z

137

Temporal targets of drug action  

Science Journals Connector (OSTI)

...or Medicine recognized the role of the hypothalamus in orienting us in space. How does our orientation in time, in the same brain region, intersect with this system? The range of integrative signals between the master clock in the hypothalamus and peripheral...

Garret A. FitzGerald

2014-11-21T23:59:59.000Z

138

E-Print Network 3.0 - anticancer drug pump Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology Summary: drug efflux pumps, increasing drug metabolism, enhancing self-repairing ability or expressing altered......

139

Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth  

E-Print Network [OSTI]

Assembly of functional nanocomponents offers promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery ...

Wong, Cliff R. (Cliff Richard)

2011-01-01T23:59:59.000Z

140

Are primary health care centres that target injecting drug users attracting and serving the clients they are designed for? A case study from Sydney, Australia  

Science Journals Connector (OSTI)

Background Low-threshold primary healthcare (PHC) centres targeting injecting drug users (IDUs) are increasingly being created to offer preventative and opportunistic services. However, no data are available on the characteristics of clients who utilise such services, or the effectiveness of these services in facilitating prevention or treatment. Method A retrospective clinical record audit examined the characteristics, service utilisation patterns and referral uptake of 384 clients presenting to a low-threshold PHC service in Sydney, Australia. Results Of the 384 clients, 85% were IDUs. Sixty-two percent reported also having access to a general medical practitioner (GP), with this group more likely to report taking benzodiazepines or other psychoactive medication. Despite this relatively high level of GP access, only 50% were fully vaccinated against hepatitis B virus (HBV). Testing for blood-borne viral and sexually transmitted infections were the most common reasons for presentation to the PHC. Most (82%) clients made at least one return visit, with an average of 3.5 presentations per client. All clients were offered HBV vaccination where indicated (n = 145); and more than half (55%) of referrals to external services were attended. Clients accessing this PHC were younger, more likely to be male and born outside Australia than \\{IDUs\\} attending needle syringe programs (NSPs) in Australia's most populous state, New South Wales. Conclusion Results suggest that this low-threshold PHC service was underutilised and its role as a low-threshold healthcare outlet remains limited. Further research is needed to more clearly delineate the health and economic benefits of this model.

M. Mofizul Islam; Libby Topp; Katherine M. Conigrave; Ann White; Paul S. Haber; Carolyn A. Day

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
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141

TARGETING TRICLOSAN  

Science Journals Connector (OSTI)

TARGETING TRICLOSAN ... FEDERAL REGULATORS are worried about the potential for antibiotic resistance and endocrine disruption from human exposure to triclosan, an antibacterial ingredient found in numerous consumer products, including soaps, body washes, cutting boards, and toys. ... “Existing data raise valid concerns about the effects of repetitive daily human exposure” to triclosan, the Food & Drug Administration wrote in a letter to Rep. Edward J. Markey (D-Mass.), which he released on April 8. ...

BRITT ERICKSON

2010-04-19T23:59:59.000Z

142

Nanomedicine and drug delivery: a mini review  

Science Journals Connector (OSTI)

The field of nanotechnology now has pivotal roles in electronics, biology and medicine. Its application can be appraised, as it involves the materials to be designed at atomic and molecular level. Due to the a...

Agha Zeeshan Mirza; Farhan Ahmed Siddiqui

2014-02-01T23:59:59.000Z

143

NCI Image-Guided Drug Delivery Summit  

Science Journals Connector (OSTI)

...effects on human health and quality of life. Implications for...statisticians, mathematicians, engineers, and computer scientists...mathematicians, statisticians, and engineers in addition to computer scientists...Sequence verification as quality control step for production...

Pushpa Tandon and Keyvan Farahani

2011-01-15T23:59:59.000Z

144

Physicochemical investigations of a drug delivery oscillator  

E-Print Network [OSTI]

75 mM Glucose/10 % MAA /kmarble= 0.00199 s-1 I = 50 mM (50 mM NaCl+0 mM CaCl2) I = 95 mM (50 mM NaCl + 15 mM CaCl2) I = 155 mM (50 mM NaCl+ 35 mM CaCl2) I = 155 mM (155 mM NaCl+ 0 mM CaCl2) p H Device Membrane - Hydrogel N...4.6 4.7 4.8 4.9 5 5.1 5.2 5.3 5.4 0 0.2 0.4 0.6 0.8 1 Time (Days) p H Glucose Gluconic acid Gluconic acid Gluconate- + H+ H+ + CaCO3 Ca 2+ + HCO3- H+ + HCO3- H2CO3 pKa = 6.37 H2CO3 CO2 ? + H2O pKa = 3.6 ? Buffer Build-Up Affects...

Bhalla, A. S.; Siegel, R. A.

2006-10-27T23:59:59.000Z

145

NANOTECHNOLOGY IN DIAGNOSTICS AND DRUG DELIVERY  

Science Journals Connector (OSTI)

The current state nanotechnology is comparable with the level of technological ... for a large portion of manufactured goods. Nanotechnology industry is currently in an equivalent infant ... , will reach $1 trill...

Hwa A. Lim

2004-07-01T23:59:59.000Z

146

Drug delivery device for bladder disorders  

E-Print Network [OSTI]

Several pathologies associated with the bladder have wide impacts on society. Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are chronic urological conditions characterized by pain, ...

Lee, Heejin, 1976-

2009-01-01T23:59:59.000Z

147

Laser postionization secondary neutral mass spectrometry in tissue: a powerful tool for elemental and molecular imaging in the development of targeted drugs  

Science Journals Connector (OSTI)

...32 Chandra S, Lorey DRI, Smith DR. Quantitative subcellular secondary ion mass spectrometry (SIMS) imaging of boron-10 and boron-11 isotopes in the same cell delivered by two combined BNCT drugs: in vitro studies on human glioblastoma...

Andrea Wittig; Heinrich F. Arlinghaus; Christian Kriegeskotte; Raymond L. Moss; Klaas Appelman; Kurt W. Schmid; Wolfgang A.G. Sauerwein

2008-07-01T23:59:59.000Z

148

Gaseous Hydrogen Delivery Breakout - Strategic Directions for...  

Broader source: Energy.gov (indexed) [DOE]

Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop...

149

Development of an interleukin 2 receptor targeted gene therapy vehicle  

E-Print Network [OSTI]

antibody to the IL-2R was used to target the oligonucleotide delivery vehicle which consisted of a polyamidoamine dendrimer. Optimization of the delivery vehicle involves understanding the factors that govern its association with oligonucleotide...

Wattanakaroon, Wanida

2006-08-16T23:59:59.000Z

150

Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...EXPERIMENTAL THERAPEUTICS Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs...India We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs...histopathology, suggesting that the nanoparticle drug delivery system has potential...

Christine M. Johnson; Rajesh Pandey; Sadhna Sharma; G. K. Khuller; Randall J. Basaraba; Ian M. Orme; Anne J. Lenaerts

2005-10-01T23:59:59.000Z

151

Hydrogen Delivery Analysis Models  

Broader source: Energy.gov [DOE]

DOE H2A Delivery Models: Components Model (delivery system component costs and performance) and Scenario Model (for urban and rural/interstate markets and demand levels, market penetration)

152

Fuel Cell Technologies Office: Strategic Directions for Hydrogen Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Strategic Directions for Hydrogen Delivery Workshop Strategic Directions for Hydrogen Delivery Workshop The U.S. Department of Energy sponsored a Hydrogen Delivery Workshop in Washington, DC, May 7-8, 2003. Attendees included researchers, government officials, and industry members. A key element of the overall hydrogen energy infrastructure is the delivery system that moves the hydrogen from its point of production to an end-use device. The DOE's Fuel Cell Technologies Office will initiate, in fiscal year 2004, a research program targeted specifically at addressing hydrogen transportation and delivery. This special workshop was held to outline the future technology and research needs for developing cost-effective, reliable, and safe hydrogen delivery systems. The proceedings of the Hydrogen Delivery Workshop, which include the presentations and the recommendations of the four breakout groups, are available as Adobe Acrobat PDFs. Download Adobe Reader.

153

Evaluation of Retrofit Delivery Packages  

SciTech Connect (OSTI)

Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

Berman, M.; Smith, P.; Porse, E.

2013-07-01T23:59:59.000Z

154

Targeting the tumor microenvironment  

SciTech Connect (OSTI)

Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

2006-11-07T23:59:59.000Z

155

Cytoplasmic transduction peptide (CTP): New approach for the delivery of biomolecules into cytoplasm in vitro and in vivo  

SciTech Connect (OSTI)

The protein transduction domain (PTD) of HIV-1 TAT has been extensively documented with regard to its membrane transduction potential, as well as its efficient delivery of biomolecules in vivo. However, the majority of PTD and PTD-conjugated molecules translocate to the nucleus rather than to the cytoplasm after transduction, due to the functional nuclear localization sequence (NLS). Here, we report a cytoplasmic transduction peptide (CTP), which was deliberately designed to ensure the efficient cytoplasmic delivery of the CTP-fused biomolecules. In comparison with PTD, CTP and its fusion partners exhibited a clear preference for cytoplasmic localization, and also markedly enhanced membrane transduction potential. Unlike the mechanism underlying PTD-mediated transduction, CTP-mediated transduction occurs independently of the lipid raft-dependent macropinocytosis pathway. The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery. In in vivo trafficking studies, CTP-fused {beta}-gal exhibited unique organ tropisms to the liver and lymph nodes when systemically injected into mice, whereas PTD-{beta}-gal exhibited no such tropisms. Taken together, our findings implicate CTP as a novel delivery peptide appropriate for (i) molecular targeting to cytoplasmic compartments in vitro, (ii) the development of class I-associated CTL vaccines, and (iii) special drug delivery in vivo, without causing any untoward effects on nuclear genetic material.

Kim, Daeyou [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); Department of Genetic Engineering, Youngdong University, Youngdong, Chungbuk (Korea, Republic of); Jeon, Choonju [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); Kim, Jeong-Hwan [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); Kim, Mi-Seon [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); Yoon, Cheol-Hee [Department of Biological Science, Sungkyunkwan University, Suwon, Gyeonggido (Korea, Republic of); Choi, In-Soo [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of); College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul (Korea, Republic of); Kim, Sung-Hoon [Graduate School of East-West Medicine, Kyunghee University, Yongin, Gyeonggido (Korea, Republic of); Bae, Yong-Soo [CreaGene Research Institute, Poi-dong 374-4, Kangnam-gu, Seoul 135-960 (Korea, Republic of) and Department of Biological Science, Sungkyunkwan University, Suwon, Gyeonggido (Korea, Republic of)]. E-mail: ysbae04@skku.edu

2006-05-01T23:59:59.000Z

156

Office of Electricity Delivery  

Energy Savers [EERE]

Office of Electricity Delivery and Energy Reliability Use of the NIST Cybersecurity Framework & DOE C2M2 CategorySubcategory CategorySubcategory CategorySubcategory Category...

157

Hydrogen Delivery Technologies and Systems - Pipeline Transmission...  

Broader source: Energy.gov (indexed) [DOE]

Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen Hydrogen Delivery...

158

Prescription Drugs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Prescription Drugs Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are different for formulary or non-formulary, generic, or brand/preferred name. Review the BCBSNM Drug List (pdf) to find out which tier a specific drug falls under. Co-pays Prescription drug co-pays vary from plan to plan. 2013 EPO Summary of Benefits (pdf) 2013 PPO Summary of Benefits (pdf)

159

Gaseous Hydrogen Delivery Breakout  

E-Print Network [OSTI]

or reduce the likelihood of hydrogen embrittlement Test existing high strength steel alloys for use in largeGaseous Hydrogen Delivery Breakout Strategic Directions for Hydrogen Delivery Workshop May 7 compression. Safety, integrity, reliability: Metal embrittlement, no H2 odorant, low ignition energy

160

Hydrogen Delivery Liquefaction & Compression  

E-Print Network [OSTI]

Hydrogen Delivery Liquefaction & Compression Raymond Drnevich Praxair - Tonawanda, NY Strategic Initiatives for Hydrogen Delivery Workshop - May 7, 2003 #12;2 Agenda Introduction to Praxair Hydrogen Liquefaction Hydrogen Compression #12;3 Praxair at a Glance The largest industrial gas company in North

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Hydrogen Delivery Options and Issues  

Broader source: Energy.gov (indexed) [DOE]

Eastman Chemical Ferco AEP Thermochem Entergy GE Framatome Stuart Energy APCi Chevron Praxair Exxonmobil BOC BP H2A Delivery Goals * Develop spreadsheet database on delivery...

162

RADIATION ONCOLOGY TARGET YOUR FUTURE  

E-Print Network [OSTI]

. · Radiation therapist - a health professional who designs, calculates (plans) and provides the radiation dose and monitors the delivery of radiation therapy, taking into account the protection and safety of patientsRADIATION ONCOLOGY TARGET YOUR FUTURE #12;A Career in Radiation Oncology YOUR CHOICE SAVE LIVES

Tobar, Michael

163

Vulnerability Analysis of Energy Delivery Control Systems - 2011 |  

Broader source: Energy.gov (indexed) [DOE]

Vulnerability Analysis of Energy Delivery Control Systems - 2011 Vulnerability Analysis of Energy Delivery Control Systems - 2011 Vulnerability Analysis of Energy Delivery Control Systems - 2011 Cybersecurity for energy delivery systems has emerged as one of the Nation's most serious grid modernization and infrastructure protection issues. Cyber adversaries are becoming increasingly targeted, sophisticated, and better financed. The energy sector must research, develop and deploy new cybersecurity capabilities faster than the adversary can launch new attack tools and techniques. The goal of the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability (DOE/OE) National Supervisory Control and Data Acquisition (SCADA) Test Bed (NSTB) program is to enhance the reliability and resiliency of the Nation's energy infrastructure by reducing the risk

164

Delivery of Boron-10 for Neutron Capture Therapy by Means of Monoclonal Antibody - Starburst Dendrimer Immunoconjugates  

Science Journals Connector (OSTI)

The use of monoclonal antibodies (MoAbs) for the delivery of radionuclides, drugs and toxins for therapeutic purposes has been the subject of intensive investigation over the past decade. A few investigators, inc...

Rolf F. Barth; Albert H. Soloway…

1992-01-01T23:59:59.000Z

165

Locoregional Cancer Treatment with Magnetic Drug Targeting  

Science Journals Connector (OSTI)

...University of Munich, 81675 Munich; Physics-Department E 17, Technical University...the instructions of Kirk and Bistners handbook of veterinarian procedures and emergency...M. R. (eds.), Kirk and Bistners Handbook of Veterinarian Procedures and Emergency...

Christoph Alexiou; Wolfgang Arnold; Roswitha J. Klein; Fritz G. Parak; Peter Hulin; Christian Bergemann; Wolfgang Erhardt; Stefan Wagenpfeil; and Andreas S. Lübbe

2000-12-01T23:59:59.000Z

166

Targeting of drugs and nanoparticles to tumors  

E-Print Network [OSTI]

The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as ...

Ruoslahti, Erkki

167

VIA EMAIL DELIVERY  

Broader source: Energy.gov (indexed) [DOE]

VIA EMAIL DELIVERY VIA EMAIL DELIVERY March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585 Lamont.Jackson@hq.doe.gov Re: Request for Information, OE Docket No. RRTT-IR-001, Rapid Response Team for Transmission Dear Mr. Jackson: TransWest Express LLC (TransWest) appreciates the opportunity to respond to the Department of Energy's questions related to permitting transmission lines, as outlined in the February 27, 2012, Federal Register notice. Per your request, the role of our company in the electric sector is as follows. TransWest is an independent transmission developer that is focused on permitting and developing the TransWest Express Transmission Project (TWE Project). The TWE Project is one of the seven

168

Hydrogen Delivery Roadmap  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery Delivery Technical Team Roadmap June 2013 This roadmap is a document of the U.S. DRIVE Partnership. U.S. DRIVE (United States Driving Research and Innovation for Vehicle efficiency and Energy sustainability) is a voluntary, non-binding, and nonlegal partnership among the U.S. Department of Energy; United States Council for Automotive Research (USCAR), representing Chrysler Group LLC, Ford Motor Company, and General Motors; Tesla Motors; five energy companies - BPAmerica, Chevron Corporation, Phillips 66 Company, ExxonMobil Corporation, and Shell Oil Products US; two utilities - Southern California Edison and DTE Energy; and the Electric Power Research Institute (EPRI). The Hydrogen Delivery Technical Team is one of 12 U.S. DRIVE technical teams ("tech teams") whose

169

Hydrogen Delivery - Basics | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Delivery Hydrogen Delivery - Basics Hydrogen Delivery - Basics Photo of light-duty vehicle at hydrogen refueling station. Infrastructure is required to move hydrogen from the...

170

Energy Delivery Systems Cybersecurity | Department of Energy  

Office of Environmental Management (EM)

Services Cybersecurity Energy Delivery Systems Cybersecurity Energy Delivery Systems Cybersecurity About the Cybersecurity for Energy Delivery Systems Program A key mission...

171

Energy Delivery Systems Cybersecurity | Department of Energy  

Energy Savers [EERE]

Cybersecurity Energy Delivery Systems Cybersecurity Energy Delivery Systems Cybersecurity About the Cybersecurity for Energy Delivery Systems Program A key mission of the...

172

Hydrogen Delivery- Current Technology  

Broader source: Energy.gov [DOE]

Hydrogen is transported from the point of production to the point of use via pipeline, over the road in cryogenic liquid trucks or gaseous tube trailers, or by rail or barge. Read on to learn more about current hydrogen delivery and storage technologies.

173

Hydrogen Storage Technologies Hydrogen Delivery  

E-Print Network [OSTI]

Hydrogen Storage Technologies Roadmap Hydrogen Delivery Technical Team Roadmap June 2013 #12;This.................................................................................. 13 6. Hydrogen Storage). The Hydrogen Delivery Technical Team is one of 12 U.S. DRIVE technical teams ("tech teams") whose mission

174

Experimental and computational investigations of therapeutic drug release from biodegradable poly(lactide-co-glycolide) (plg) microspheres  

E-Print Network [OSTI]

The need to tailor release-rate profiles from polymeric microspheres remains one of the leading challenges in controlled drug delivery. Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a...

Berchane, Nader Samir

2009-05-15T23:59:59.000Z

175

Hydrogen Delivery Liquefaction and Compression  

Broader source: Energy.gov [DOE]

Hydrogen Delivery Liquefaction and Compression - Overview of commercial hydrogen liquefaction and compression and opportunities to improve efficiencies and reduce cost.

176

STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 2009/109/109/109/10 Annual Delivery Report  

E-Print Network [OSTI]

STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 2009/109/109/109/10 0 Annual Delivery Report 2009/10 August 2010 #12;STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery

177

Magnetically-triggered Nanocomposite Membranes: a Versatile Platform for Triggered Drug Release  

E-Print Network [OSTI]

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. The dose of drug delivered can be tuned by engineering the phase transition temperature of the nanogel, the loading of nanogels in the membrane, and the membrane thickness, allowing for the delivery of drugs over several orders of magnitude of release rates. The zero-order kinetics of drug release through the membranes permit drug doses from a specific device to be tuned according to the duration of the magnetic field. Drugs over a broad range of molecular weights (500-40,000 Da) can be delivered by the same membrane device. Membrane-to-membrane and cycle-to-cycle reproducibility is demonstrated, suggesting the general utility of these membranes for drug delivery.

Todd Hoare; Brian P. Timko; Jesus Santamaria; Gerardo F. Goya; Silvia Irusta; Debora Lin; Samantha Lau; Robert Langer; Daniel S. Kohane

2011-06-27T23:59:59.000Z

178

Delivery Tech Team  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Tech Team Tech Team Oak Ridge National Laboratory January, 2005 Team Members * Tony Bouza: DOE * Nick Burkhead: SC * Dan Casey: CVX * Maria Curry- Nkansah: BP* * Jim Kegerreis: XOM * George Parks: COP** * Mark Paster: DOE** * Steve Pawel: ORNL * Jim Simnick: BP * FOG Liaison ** Co-Leads Shawna McQueen (Energetics): Facilitator Mission * Provide a forum for the Partnership to help advance research aimed at developing low cost, safe, and energy efficient hydrogen delivery systems * Catalyze the development of hydrogen delivery technologies that enable the introduction and long-term viability of hydrogen as an energy carrier for transportation and stationary power Useful Facts * 1 kg H 2 = 1 gallon gasoline * Eff FCV = 2-3 x Eff ICEV = 1.2-1.4 x Eff HEV * Energy Density - 10,000 psi H 2 = 1.3 kWhr/l

179

Office of Electricity Delivery  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery Electricity Delivery and Energy Reliability Smart Grid R&D Program DOE Microgrid Workshop Report August 30-31, 2011 San Diego, California ii Acknowledgment The U.S. Department of Energy (DOE) would like to acknowledge the support provided by the organizations represented on the workshop planning committee in developing the workshop process and sessions. The preparation of this workshop report was coordinated by Energy & Environmental Resources Group, LLC (E2RG). The report content is based on the workshop session discussions, with session summary descriptions taken from the report-out presentations by individual teams during the closing plenary. Contributions to this report by all workshop participants, via expressed viewpoints during the

180

Hydrogen Delivery Infrastructure Option Analysis  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydrogen Delivery Infrastructure Hydrogen Delivery Infrastructure Option Analysis Option Analysis DOE and FreedomCAR & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop January 25, 2005 Washington DC This presentation does not contain any proprietary or confidential information Tan-Ping Chen Nexant Jim Campbell Bhadra Grover Air Liquide Stefan Unnasch TIAX Glyn Hazelden GTI Graham Moore Chevron Matt Ringer NREL Ray Hobbs Pinnacle West 2 Presentation Outline Project Background Knowledge Collected and Preliminary Results for Each Delivery Option Summary of Observations Next Step Project Background Project Background 4 Delivery Options Option 1* GH delivery by new pipelines Option 2 Converting NG/oil pipelines for GH delivery Option 3 Blending GH into NG pipelines Option 4* GH tube trailers

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Assessing the impact of tumor evolution on oncology drug development and commercialization  

E-Print Network [OSTI]

This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...

Sterk, Joseph P. (Sterk, Joseph Phillip)

2011-01-01T23:59:59.000Z

182

Timely delivery of LIFE Tom Anklam, Lawrence Livermore  

E-Print Network [OSTI]

Timely delivery of LIFE Tom Anklam, Lawrence Livermore National Laboratory October 19, 2011 LIFE_Royal_Society_9/7/11 6 LIFE Fusion Chamber is About the Same Scale as the NIF Target Chamber #12;LIFE Fusion Physics will be Demonstrated on the NIF #12;LIFE will use a modular laser architeccture #12;#12;#12;11 NIF

183

Synthesis and characterisation of new designed protoporphyrin-stabilised gold nanoparticles for cancer cells nanotechnology-based targeting  

Science Journals Connector (OSTI)

Nanotechnology has entered the field of medicine in recent dacades and especially, in drug delivery systems, nanoparticles have shown an ability to improve pharmacokinetics, pharmacodynamics, efficacy and to reduce the toxicity of associated drugs. In this study, we have designed a new protoporphyrin-conjugated gold nanoparticle to selectively target and photo- or sonodynamic therapy of tumoural cells. In order to improve the cell uptake effect of protoporphyrin and their derivatives, gold nanoparticle was chosen as carrier. For this purpose, we used 6-mercapto-1-hexanol, as a bifunctional linker to react with protoporphyrin with an ester-linkage formation. Then, we conjugated the thiol-terminated protoporphyrin to the gold nanoparticles through a fast and single-phase system reaction with HAuCl4 in the presence of sodium borohydride. Finally, we evaluated the specific interaction between the protoporphyrin and gold nanoparticles by the elemental analysis, atomic absorption and UV-vis spectrum. Transmission electron microscopic images reveal the spherical gold nanoparticles formation with the average size about 7 nm. Therefore, we have synthesised gold nanoparticle conjugates with protoporphyrin which could be used as a biocompatible drug delivery system.

Hossein Eshghi; Neda Attaran; Ameneh Sazgarnia; Narges Mirzaie; Ahmad Shanei

2011-01-01T23:59:59.000Z

184

Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery  

Science Journals Connector (OSTI)

...realizing the potential of genetic medicine. As future therapeutics will increasingly...nano-carriers for drug delivery. Nanotechnology 16, S484-S491. ( doi:10...Williams, D. A. , and C. Baum 2003 Medicine. Gene therapy-new challenges...

2010-01-01T23:59:59.000Z

185

TIGER -- A technology to improve the delivery capability of nuclear bombs and the survivability of the delivery aircraft  

SciTech Connect (OSTI)

The TIGER (Terminal guided and Extended-Range) Program was initiated in 1972 to study improved delivery capabilities for stockpiled tactical nuclear bombs. The Southeast Asia conflict fostered the development of air-delivered standoff conventional weapons utilizing terminal guidance systems. SNL initiated the TIGER program to determine if current nuclear bombs could be provided with a similarly accurate standoff capabilities. These conventional weapon delivery techniques, while allowing highly accurate attack, generally require entering the target area at high altitude to establish line of sight to the target. In parallel with the TIGER program, system studies analyzed this concept and showed marked improvement in aircraft and weapon survivability with moderate standoff (10--20 km) if low level deliveries (60 m) could be accomplished. As a result of this work, the TIGER program was redirected in early 1974 to demonstrate a standoff bomb with good accuracy (90 m CEP) when delivered from low flying aircraft. This program redirection resulted in the selection of an inertial guidance system to replace the earlier terminal guidance systems. This program was called the Extended-Range Bomb (ERB). In May 1974, a joint Air Force/DOE study identified the desirability of having a single tactical weapon which could be employed against either fixed, preselected targets, or mobile battlefield targets. Studies conducted on the ERB system showed that the inertially guided weapon could fly not only the standoff mission but also a return-to-target mission against the mobile battlefield targets whose locations are not known accurately enough to use a standoff delivery. The ERB program evolved from these initial investigations into an exploratory program to develop the hardware and demonstrate the technology required to fly standoff and return-to-target trajectories. The application of this technology in the form of field retrofit kits to the B61 bomb is called TIGER II.

NONE

1980-12-31T23:59:59.000Z

186

FCT Hydrogen Delivery: Current Technology  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Current Technology to someone Current Technology to someone by E-mail Share FCT Hydrogen Delivery: Current Technology on Facebook Tweet about FCT Hydrogen Delivery: Current Technology on Twitter Bookmark FCT Hydrogen Delivery: Current Technology on Google Bookmark FCT Hydrogen Delivery: Current Technology on Delicious Rank FCT Hydrogen Delivery: Current Technology on Digg Find More places to share FCT Hydrogen Delivery: Current Technology on AddThis.com... Home Basics Current Technology R&D Activities Quick Links Hydrogen Production Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Current Technology Today, hydrogen is transported from the point of production to the point of use via pipeline, over the road in cryogenic liquid trucks or gaseous tube

187

Antiretroviral drugs  

Science Journals Connector (OSTI)

In October 2010, it will be exactly 25 years ago that the first antiretroviral drug, AZT (zidovudine, 3?-azido-2?,3?-dideoxythymidine), was described. It was the first of 25 antiretroviral drugs that in the past 25 years have been formally licensed for clinical use. These antiretroviral drugs fall into seven categories [nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), fusion inhibitors (FIs), co-receptor inhibitors (CRIs) and integrase inhibitors (INIs). The \\{INIs\\} (i.e. raltegravir) represent the most recent advance in the search for effective and selective anti-HIV agents. Combination of several anti-HIV drugs [often referred to as highly active antiretroviral therapy (HAART)] has drastically altered AIDS from an almost uniformly fatal disease to a chronic manageable one.

Erik De Clercq

2010-01-01T23:59:59.000Z

188

A new weapon against an old target  

Science Journals Connector (OSTI)

High expression of folate receptors is characteristic for the effector cell population of synovial macrophages in synovial inflammation. A new drug conjugate, EC0746, targets the folate inhibitor aminopterin t...

Christoph Fiehn

2011-08-01T23:59:59.000Z

189

Bacteria-mediated in vivo delivery of quantum dots into solid tumor  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer New approach using the probiotic Bifidobacterium bifidum as a vehicle to deliver QDs into the deep tissue of solid tumors in vivo was achieved. Black-Right-Pointing-Pointer Bifidobacterium bifidum delivery system has intrinsic biocompatibility. Black-Right-Pointing-Pointer The targeting efficacy was improved by folic acids. -- Abstract: Semiconductor nanocrystals, so-called quantum dots (QDs), promise potential application in bioimaging and diagnosis in vitro and in vivo owing to their high-quality photoluminescence and excellent photostability as well as size-tunable spectra. Here, we describe a biocompatible, comparatively safe bacteria-based system that can deliver QDs specifically into solid tumor of living animals. In our strategy, anaerobic bacterium Bifidobacterium bifidum (B. bifidum) that colonizes selectively in hypoxic regions of animal body was successfully used as a vehicle to load with QDs and transported into the deep tissue of solid tumors. The internalization of lipid-encapsuled QDs into B. bifidum was conveniently carried by electroporation. To improve the efficacy and specificity of tumor targeting, the QDs-carrying bacterium surface was further conjugated with folic acids (FAs) that can bind to the folic acid receptor overexpressed tumor cells. This new approach opens a pathway for delivering different types of functional cargos such as nanoparticles and drugs into solid tumor of live animals for imaging, diagnosis and therapy.

Liu, Ying [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)] [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Zhou, Mei [Dept. of Radiation Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)] [Dept. of Radiation Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Luo, Dan; Wang, Lijun; Hong, Yuankai [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)] [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Yang, Yepeng, E-mail: yangyepeng@bjmu.edu.cn [Dept. of Radiation Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)] [Dept. of Radiation Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Sha, Yinlin, E-mail: shyl@hsc.pku.edu.cn [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China) [Single-molecule and Nanobiology Lab., Dept. of Biophysics, School of Basic Medical Sciences, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China); Biomed-X Center, Peking University, Peking University, No. 38 Xue Yuan Road, Beijing 100091 (China)

2012-09-07T23:59:59.000Z

190

Delivery Analysis | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

(1998) Home About the Fuel Cell Technologies Office Hydrogen Production Hydrogen Delivery Hydrogen Storage Fuel Cells Technology Validation Manufacturing Safety, Codes, and...

191

Targeting Ras in Myeloid Leukemias  

Science Journals Connector (OSTI)

...which are activated as a downstream consequence of ligand binding to growth factor receptors...case of mutant Ras due to structural consequences of substations at codons 12, 13, and...as a therapeutic target in cancer. In truth, these drugs do not significantly inhibit...

Benjamin S. Braun and Kevin Shannon

2008-04-15T23:59:59.000Z

192

Applications of triazine chemistry: education, remediation, and drug delivery  

E-Print Network [OSTI]

and its effect on the environment and society. The modification of chitosan for herbicide remediation has been accomplished using triazine chemistry, as well. Treatment of chitosan iteratively with cyanuric chloride followed by piperazine produces...

Hatfield, Susan Elizabeth

2009-05-15T23:59:59.000Z

193

Glutamate-Leucine Block Copolypeptides for Drug Delivery  

E-Print Network [OSTI]

310 -b-poly(acrylic acid) 36 (PS 310 -b-PAA 36 ) vesicles.Since PS 310 -b- PAA 36 , which consists of a negatively-properties to the PS 310 -b-PAA 36 vesicle bilayer. They

Lee, Brian Sangwoo

2014-01-01T23:59:59.000Z

194

Electricity Delivery and Energy Reliability | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability Electricity Delivery and Energy Reliability information about the delivery of electricity and energy reliability Electricity Delivery...

195

Network predicting drug's anatomical therapeutic chemical code  

Science Journals Connector (OSTI)

......validated on four drug datasets with various target...couple receptors and nuclear receptors. We found...well-collected drug datasets, the ATC-code assignments...For example, the dataset in Yamanishi et al...receptors (GPCRs) and nuclear receptors (NRs......

Yong-Cui Wang; Shi-Long Chen; Nai-Yang Deng; Yong Wang

2013-05-15T23:59:59.000Z

196

Capital Projects Delivery Procedures Manual  

E-Print Network [OSTI]

1 Capital Projects Delivery Procedures Manual September 4, 2008 Office of the CFO #12;2 Page I of the Capital Budget 11 B. Budget Approval 12 C. Setting Up Capital Projects 13 III. Procedures for Design ­ Office of the Chief Financial Officer Financial Policies and Procedures for the Capital Project Delivery

Alpay, S. Pamir

197

Hydrogen Production and Delivery Research  

SciTech Connect (OSTI)

In response to DOE's Solicitation for Grant Applications DE-PS36-03GO93007, 'Hydrogen Production and Delivery Research', SRI International (SRI) proposed to conduct work under Technical Topic Area 5, Advanced Electrolysis Systems; Sub-Topic 5B, High-Temperature Steam Electrolysis. We proposed to develop a prototype of a modular industrial system for low-cost generation of H{sub 2} (<$2/kg) by steam electrolysis with anodic depolarization by CO. Water will be decomposed electrochemically into H{sub 2} and O{sub 2} on the cathode side of a high-temperature electrolyzer. Oxygen ions will migrate through an oxygen-ion-conductive solid oxide electrolyte. Gas mixtures on the cathode side (H{sub 2} + H{sub 2}O) and on the anode side (CO + CO{sub 2}) will be reliably separated by the solid electrolyte. Depolarization of the anodic process will decrease the electrolysis voltage, and thus the electricity required for H{sub 2} generation and the cost of produced H{sub 2}. The process is expected to be at least 10 times more energy-efficient than low-temperature electrolysis and will generate H{sub 2} at a cost of approximately $1-$1.5/kg. The operating economics of the system can be made even more attractive by deploying it at locations where waste heat is available; using waste heat would reduce the electricity required for heating the system. Two critical targets must be achieved: an H{sub 2} production cost below $2/kg, and scalable design of the pilot H{sub 2} generation system. The project deliverables would be (1) a pilot electrolysis system for H{sub 2} generation, (2) an economic analysis, (3) a market analysis, and (4) recommendations and technical documentation for field deployment. DOE was able to provide only 200K out of 1.8M (or about 10% of awarded budget), so project was stopped abruptly.

Iouri Balachov, PhD

2007-10-15T23:59:59.000Z

198

Delivery of neuroactive peptide drugs to the brain via intranasal delivery  

E-Print Network [OSTI]

presents a human plasma stability assay on a racemic lipoamino acid Leu-enkephalin derivative. Methods Caco-2 Permeability assay: Caco-2 cells form tight monolayer structures when seeded on to polycarbonate filters. To assess permeability, a 200 ?M... is the initial concentration in the donor chamber. Plasma stability assay: This assay was performed by mixing 300?L of a solution of C8Laa- Enkephalin (1mg/mL) with 300?L of plasma prewarmed at 37.5????C. At chosen time points, 50?L of the plasma mixture...

Cros, C. D.; Toth, I.; Blanchfield, J.

2006-10-27T23:59:59.000Z

199

Numerical simulation investigations in weapon delivery probabilities .  

E-Print Network [OSTI]

??The study of weapon delivery probabilities has historically been focused around analytical solutions and approximations for weapon delivery accuracy and effectiveness calculations. With the relatively… (more)

Peterson, Kristofer A.

2008-01-01T23:59:59.000Z

200

Cryocompressed Hydrogen Storage and Liquid Delivery  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Cryocompressed Hydrogen Storage & Liquid Delivery Jacob Leachman, Ph.D. Assistant Professor DOE H 2 Transmission & Delivery Workshop 2262014 H Y P E R H drogen roperties for...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

ELECTRICITY DELIVERY AND ENERGY RELIABILITY Appropriation Overview  

Broader source: Energy.gov (indexed) [DOE]

ELECTRICITY DELIVERY AND ENERGY RELIABILITY Appropriation Overview Electricity Delivery and Energy Reliability (OE) drives electric grid modernization and resiliency in the energy...

202

A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles  

E-Print Network [OSTI]

The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles ...

Eavarone, David A.

203

Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating  

E-Print Network [OSTI]

Electrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a “pharmacy-on-a-chip”). Here we report the fabrication ...

Schmidt, Daniel J.

204

Prolonged Serum Half-Life of Antineoplastic Drugs by Incorporation into the Low Density Lipoprotein  

Science Journals Connector (OSTI)

...cells. J. Supramol. Struct., 10: 467-478, 1979. Shaw. J. M.. Shaw. K. V., Yanovich, S., Iwanik. M., Futch, W. S., Rosowsky, A., and Schook, L. B. Delivery of lipophilic drugs using lipoproteins. Ann. NY Acad. Sci...

P. Chris de Smidt and Theo J. C. van Berkel

1990-12-01T23:59:59.000Z

205

Methodology for the production and delivery of generative music for the personal listener : systems for realtime generative music production   

E-Print Network [OSTI]

This thesis will describe a system for the production of generative music through specific methodology, and provide an approach for the delivery of this material. The system and body of work will be targeted specifically ...

Murphy, Michael J.

2013-11-27T23:59:59.000Z

206

Hydrogen Delivery Infrastructure Options Analysis  

Fuel Cell Technologies Publication and Product Library (EERE)

This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

207

Hydrogen Delivery Infrastructure Option Analysis  

Broader source: Energy.gov (indexed) [DOE]

pipes - Operating pressure is 35% rather than typical 72% of allowable stress 20-25% less energy delivered (excluding pressure de-rating): Overall, delivery capacity is de-rated by...

208

Hydrogen Distribution and Delivery Infrastructure  

Fuel Cell Technologies Publication and Product Library (EERE)

This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

209

Radiation delivery system and method  

DOE Patents [OSTI]

A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

Sorensen, Scott A. (Overland Park, KS); Robison, Thomas W. (Los Alamos, NM); Taylor, Craig M. V. (Jemez Springs, NM)

2002-01-01T23:59:59.000Z

210

DOE Hydrogen and Fuel Cells Program Record 13013: Hydrogen Delivery Cost Projections - 2013  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3013 Date: September 26, 2013 3013 Date: September 26, 2013 Title: H 2 Delivery Cost Projections - 2013 Originator: E. Sutherland, A. Elgowainy and S. Dillich Approved by: R. Farmer and S. Satyapal Date: December 18, 2013 Item: Reported herein are past 2005 and 2011 estimates, current 2013 estimates, 2020 projected cost estimates and the 2015 and 2020 target costs for delivering and dispensing (untaxed) H 2 to 10%- 15% of vehicles within a city population of 1.2M from a centralized H 2 production plant located 100 km from the city gate. The 2011 volume cost estimates are based on the H2A Hydrogen Delivery Scenario Analysis Model (HDSAM) V2.3 projections and are employed as the basis for defining the cost and technical targets of delivery components in Table 3.2.4 in the 2012 Delivery

211

Hydrogen Delivery Technology Roadmap, November 2005  

Fuel Cell Technologies Publication and Product Library (EERE)

Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

212

Targeting the BCR-ABL Signaling Pathway in Therapy-Resistant Philadelphia Chromosome-Positive Leukemia  

Science Journals Connector (OSTI)

...cycle-targeted drugs currently in the pipeline for testing in early-phase...investigation (14). Such pipeline drugs are not easily accessible...degradation of this nuclear repair enzyme is a sensitive indicator...cycle-targeted drugs currently in the pipeline for testing in early-phase...

Thomas O'Hare; Michael W.N. Deininger; Christopher A. Eide; Tim Clackson; and Brian J. Druker

2011-01-15T23:59:59.000Z

213

Delivery quality assurance with ArcCHECK  

SciTech Connect (OSTI)

Radiation therapy requires delivery quality assurance (DQA) to ensure that treatment is accurate and closely follows the plan. We report our experience with the ArcCHECK phantom and investigate its potential optimization for the DQA process. One-hundred seventy DQA plans from 84 patients were studied. Plans were classified into 2 groups: those with the target situated on the diodes of the ArcCHECK (D plans) and those with the target situated at the center (C plans). Gamma pass rates for 8 target sites were examined. The parameters used to analyze the data included 3%/3 mm with the Van Dyk percent difference criteria (VD) on, 3%/3 mm with the VD off, 2%/2 mm with the VD on, and x/3 mm with the VD on and the percentage dosimetric agreement “x” for diode plans adjusted. D plans typically displayed maximum planned dose (MPD) on the cylindrical surface containing ArcCHECK diodes than center plans, resulting in inflated gamma pass rates. When this was taken into account by adjusting the percentage dosimetric agreement, C plans outperformed D plans by an average of 3.5%. ArcCHECK can streamline the DQA process, consuming less time and resources than radiographic films. It is unnecessary to generate 2 DQA plans for each patient; a single center plan will suffice. Six of 8 target sites consistently displayed pass rates well within our acceptance criteria; the lesser performance of head and neck and spinal sites can be attributed to marginally lower doses and increased high gradient of plans.

Neilson, Christopher; Klein, Michael; Barnett, Rob [London Regional Cancer Program, London Health Sciences Centre, London, Ontario (Canada); Yartsev, Slav, E-mail: slav.yartsev@lhsc.on.ca [London Regional Cancer Program, London Health Sciences Centre, London, Ontario (Canada)

2013-04-01T23:59:59.000Z

214

Accelerator target  

DOE Patents [OSTI]

A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

1999-06-29T23:59:59.000Z

215

Measurement of photodynamic therapy drug concentrations in a tissue  

SciTech Connect (OSTI)

This is the final report of a one-year laboratory-directed research and development project at the Los Alamos National Laboratory (LANL). Photodynamic therapy (PDT) is an experimental treatment modality for cancer in which a photoactive molecule with an affinity for tumors in administered to the patient, then excited by light. Photoactivation creates singlet oxygen consequently killing the tissue. Knowledge of the concentration of the photoactive compound in the tissue is necessary for proper light dosimetry during PDT. Presently, the control of light application is problematic. If too much light is applied, damage to the surrounding tissue will occur. If insufficient light is applied, the targeted tissue volume will remain viable. The ideal implementation of PDT would use a feedback system for light delivery that incorporates the optical properties of the tissue and knowledge of the concentration of the photoactive compound. This project sought to develop a method for measuring photosensitizer concentrations in tissue phantoms that will lead to a noninvasive, endoscopically compatible, in vivo method of measuring PST drug concentrations.

Mourant, J.; Biglo, I.; Johnson, T.

1996-09-01T23:59:59.000Z

216

Materializing the Potential of Small Interfering RNA via a Tumor-Targeting Nanodelivery System  

Science Journals Connector (OSTI)

...tumor-targeting systemic delivery system may be one means to...tumor-targeted nanodelivery system to improve early MRI detection of cancer. Mol Imaging...tumor-targeting nanodelivery system. | The field of small...the availability of a vehicle that can be systemically...

Kathleen F. Pirollo; Antonina Rait; Qi Zhou; Sung Hee Hwang; John A. Dagata; Gerald Zon; Richard I. Hogrefe; Guillermo Palchik; and Esther H. Chang

2007-04-01T23:59:59.000Z

217

Hydrogen Delivery Options and Issues  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Options and Issues Options and Issues Mark Paster DOE August, 2006 Scope * From the end point of central or distributed production (300 psi H2) to and including the dispenser at a refueling station or stationary power site - GH2 Pipelines and Trucks, LH2 Trucks, Carriers <$1.00/kg of Hydrogen by 2017 Hydrogen Delivery H2 Delivery Current Status * Technology - GH2 Tube Trailers: ~340 kg, ~2600 psi - LH2 Trucks: ~3900 kg - Pipelines: up to 1500 psi (~630 miles in the U.S.) - Refueling Site Operations (compression, storage dispensing): Demonstration projects * Cost (Does NOT include refueling Site Operations) - Trucks: $4-$12/kg - Pipeline: <$2/kg H2A Analysis * Consistent, comparable, transparent approach to hydrogen production and delivery cost analysis * Excel spreadsheet tools with common economic

218

Comments of Oncor Electric Delivery Company LLC | Department...  

Broader source: Energy.gov (indexed) [DOE]

Comments of Oncor Electric Delivery Company LLC Comments of Oncor Electric Delivery Company LLC Comments of Oncor Electric Delivery Company LLC on Implementing the National...

219

Agenda for the Hydrogen Delivery and Onboard Storage Analysis...  

Broader source: Energy.gov (indexed) [DOE]

Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and...

220

Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

The Office of Electricity Delivery and Energy Reliability (OE) drives electric grid modernization and resiliency in the energy infrastructure while working to enable innovation across the energy sector, empowering American consumers, and securing our energy future. The OE mission and the leadership role OE plays in the energy industry directly support the President's effort to accelerate the transformation of America's energy system

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

California Natural Gas International Deliveries (Million Cubic...  

U.S. Energy Information Administration (EIA) Indexed Site

Deliveries (Million Cubic Feet) California Natural Gas International Deliveries (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

222

Delivery Tech Team | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Delivery Tech Team Delivery Tech Team Presentation by 02-Parks to DOE Hydrogen Pipeline R&D Project Review Meeting held January 5-6, 2005 at Oak Ridge National Laboratory in Oak...

223

Strategic Directions for Hydrogen Delivery Workshop Proceedings  

Broader source: Energy.gov [DOE]

Proceedings from the Strategic Directions for Hydrogen Delivery Workshop held May 7-8, 2003 in Washington, DC. Author: Energetics

224

Optical measurement of drug concentrations in tissue  

SciTech Connect (OSTI)

This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The aim of this project was to develop noninvasive fiber-optic methods for measuring drug concentrations in tissue. Such a system would make possible the study of chemotherapy drug kinetics at specific, targeted locations in the body after the drug is administered. The major result of this project is the development of techniques for measuring changes in absorption of a medium with unknown scattering properties. The developed method was verified by testing on several media with scattering properties in the range typically found for tissue.

Mourant, J.R.; Bigio, I.J.; Jack, D.A.; Johnson, T.M.; Miller, H.D. [Los Alamos National Lab., NM (United States). Chemical Sciences and Technology Div.

1997-10-01T23:59:59.000Z

225

Delivery and Hedging Delivery ties the futures price to the spot price.  

E-Print Network [OSTI]

Delivery and Hedging · Delivery ties the futures price to the spot price. · On the delivery date, the settlement price of the futures contract is determined by the spot price. · Hence, when the delivery period is reached, the futures price should be very close to the spot price. · Changes in futures prices usually

Lyuu, Yuh-Dauh

226

Energy Tradeoffs among Content Delivery Architectures  

E-Print Network [OSTI]

Energy Trade­offs among Content Delivery Architectures Anja Feldmann Andreas Gladisch Mario Kind to incorporate var­ ious home devices such as set­top boxes into content delivery architectures using the Peer­to­Peer (P2P) paradigm. The hope is to enhance the efficiency of content delivery, e.g., in terms

Smaragdakis, Georgios

227

Japan Retools Drug Research  

Science Journals Connector (OSTI)

Japan Retools Drug Research ... Like Takeda’s stock price, Japan’s drug R&D engine—flagging in recent years—appears to be recovering. ...

JEAN-FRANÇOIS TREMBLAY

2013-08-05T23:59:59.000Z

228

Abstract 4036: Drug repurposing to treat melanoma brain metastases  

Science Journals Connector (OSTI)

...4036: Drug repurposing to treat melanoma brain metastases Terje Sundstrom 1 Jobin K...of patients with metastatic melanoma, brain metastases remain an intractable problem...target single genes or pathways critical to brain metastasis formation. In this work we...

Terje Sundstrøm; Jobin K. Varughese; Francisco Azuaje; Kjell Petersen; Clifford G. Tepper; Elizabeth Ingham; Lisa Even; Sarah Tam; Kai Ove Skaftnesmo; Morten Lund-Johansen; Rolf Bjerkvig; Katherine W. Ferrara; Frits A. Thorsen

2014-10-01T23:59:59.000Z

229

Machine and Beam Delivery Updates  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

MAchine and Beam delivery Updates FY13 MAchine and Beam delivery Updates FY13 Summary of Beam Delivery: FACET Summary Feb_15_22.pdf FACET Summary Feb_15_22.pdf FACET Summary Feb_23_Mar_1.pdf FACET Summary Feb_23_Mar_1.pdf FACET Summary Mar_2_8.pdf FACET Summary Mar_2_8.pdf FACET Summary Mar_9_15.pdf FACET Summary Mar_9_15.pdf FACET Summary Mar_16_22.pdf FACET Summary Mar_16_22.pdf FACET Summary Mar_23_29.pdf FACET Summary Mar_23_29.pdf FACET Summary Mar_30_Apr_5.pdf FACET Summary Mar_30_Apr_5.pdf FACET Summary Apr_6_12.pdf FACET Summary Apr_6_12.pdf FACET Summary Apr_27_May_3.pdf FACET Summary Apr_27_May_3.pdf FACET Summary May_4_10.pdf FACET Summary May_4_10.pdf Emittance Stability in Sector 2_31513.pdf Emittance Stability in Sector 2_31513.pdf FACET beam operations readiness with R56.pdf FACET beam operations readiness with R56.pdf (6/19/2013)

230

Light Sources Help Discover New Drug Against Melanoma | Department of  

Broader source: Energy.gov (indexed) [DOE]

Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. Mike Ross Science Writer at SLAC National Accelerator Laboratory What does this mean for me? A new drug designed to fight melanoma was discovered thanks to the

231

Genomics Rises To Drug Discovery Challenge  

Science Journals Connector (OSTI)

Genomics Rises To Drug Discovery Challenge ... Functional genomics and functional proteomics provide a set of powerful tools to help identify novel cellular targets ... With pharmaceutical companies and biotechnology firms always looking for ways to discover new medicines more quickly and more efficiently, they are increasingly turning to new genomics and proteomics technologies to speed things along. ...

STU BORMAN

1999-04-19T23:59:59.000Z

232

Identifying novel drug indications through automated reasoning Authors and Affiliations  

E-Print Network [OSTI]

of these drugs have potential anti-cancer activities based on information on their targets and molecular discovery, text mining, automated reasoning Abstract Background With the large amount of pharmacological interaction types alone. A total of 507 drugs were found to have the potential to be used for cancer

Baral, Chitta

233

Fiber coupled optical spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO)

2008-08-12T23:59:59.000Z

234

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydrogen Hydrogen Storage Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Breakout Session - Bulk Hydrogen Storage Main Themes/Caveats Bulk Storage = Anything not on the vehicle 10's of Tons -- End use point 50-100 Tons - Terminals/City Gates 1000's Tons - Between Production Facility and Terminal/City Gate Bulk storage requirements less restrictive and different from on-board storage Uncertainty about evolution of infrastructure requires multiple pathways to be considered Bulk storage is an economic solution to address supply/demand imbalance Breakout Session - Bulk Hydrogen Storage Targets/Objectives Hard to quantify - scenario & end-use dependent Storage Materials (solid state) and container require different targets

235

Strategic Directions for Hydrogen Delivery Workshop  

Broader source: Energy.gov [DOE]

The U.S. Department of Energy sponsored a Hydrogen Delivery Workshop in Washington, DC, May 7-8, 2003. Attendees included researchers, government officials, and industry members.

236

Hydrogen Delivery Technologies and Systems - Pipeline Transmission...  

Broader source: Energy.gov (indexed) [DOE]

Technologies and Systems Pipeline Transmission of Hydrogen Strategic Initiatives for Hydrogen Delivery Workshop May 7- 8, 2003 U.S. Department of Energy Hydrogen, Fuel Cells,...

237

Final Report- Hydrogen Delivery Infrastructure Options Analysis  

Broader source: Energy.gov [DOE]

This report provides in-depth analysis of various hydrogen delivery options to determine the most cost effective infrastructure and R&D efforts for the long term.

238

Potential Carriers and Approaches for Hydrogen Delivery  

Broader source: Energy.gov [DOE]

Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

239

Part IV: Section F: Deliveries and Performance  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

or the period of the order or any extension thereof expires, the Contractor shall resume work. The Contracting Officer shall make an equitable adjustment in the delivery...

240

MFRC Training Development & Delivery Program - Bloodstain & Toxicology...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Resource Center (MFRC) Training Development and Delivery Program increases access to forensic science training for publicly funded state and local forensic scientists. Its goals...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Drug Conjugates Lure Investment  

Science Journals Connector (OSTI)

Drug Conjugates Lure Investment ... Only two antibody-drug conjugates are on the market— Roche’s Kadcyla for breast cancer and Seattle Genetics’s Adcetris for lymphoma—but developers are stepping up investment in this new drug class. ... The new plant is part of a larger investment by the company in biologics manufacturing (see page 17). ...

ANN THAYER

2013-10-21T23:59:59.000Z

242

Gaussian interaction profile kernels for predicting drug–target interaction  

Science Journals Connector (OSTI)

......2009). For the GPCR and nuclear receptor datasets, the method with the highest...Ion Channel, GPCR and nuclear receptor datasets, respectively. These results...predictions. Finally, on the Nuclear Receptor dataset, BY09 and RLS-Kron-avg......

Twan van Laarhoven; Sander B. Nabuurs; Elena Marchiori

2011-11-01T23:59:59.000Z

243

Pharmacokinetics, or "How a drug reaches its target"  

E-Print Network [OSTI]

15 20 25 30 35 40 45 Time (days) Concentration(mg·L-1) InL Michaelis-Menten(L) Cld CP, VcCt, Vt koff ke(RL) InL L = Ligand R = receptor RL = Receptor-Ligand complex ke(L) Parameter fit for data set 2 The dynamics is given by the system of nonlinear differential equations: dL dt = InL - konL · R + koff

Gugat, Martin

244

Adenosine A2A Receptor as a Drug Discovery Target  

Science Journals Connector (OSTI)

Binodenoson development appears to have been halted after Pfizer acquired King Pharmaceuticals, since binodenoson is not listed in Pfizer’s pipeline. ... Importantly, these results demonstrate that the orally active dual adenosine A2A and A1 receptor antagonist 62 can repair motor impairments via A2A receptor antagonism. ... As a result, compound 72, which is a potent adenosine A2A receptor antagonist (hA2A Ki = 0.4 nM) with good selectivity over the human A1 receptor (100-fold), showed a clean hERG profile (patch-clamp IC50 = 1200 nM) and good aqueous solubility (0.21 mg/mL, pH 5). ...

Manuel de Lera Ruiz; Yeon-Hee Lim; Junying Zheng

2013-10-28T23:59:59.000Z

245

LIFE Economics and Delivery Pathway Presentation to  

E-Print Network [OSTI]

risk to acceptable levels · Quantified in terms of confidence level that an issue has been demonstrated;Delivery plan reduces risk to commercially acceptable levels ·Fusion delivery abstracted to 38 core is necessary (but not sufficient) for economic viability Minimumforeconomics Cost and risk to buy additional

246

Delivery of Hydrogen Produced from Natural Gas  

E-Print Network [OSTI]

for transportation and stationary power. DOE Milestone #12;Hydrogen Delivery Options · Gaseous hydrogen - Pipelines · Materials Development - Repair, smart pipe, liners · Operational Technologies - Compressors, modeling, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas

247

Potential Carriers and Approaches for Hydrogen Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Carriers and Potential Carriers and Carriers and Potential Carriers and Approaches for Hydrogen Approaches for Hydrogen Delivery Delivery TIAX LLC 1601 S. D Anza Blvd. Cupertino CA, 95014 Tel. 408-517-1550 Reference: D0348 © 2007 TIAX LLC Hydrogen Delivery Analysis Meeting May 8-9, 2007 Columbia, Maryland Matthew Hooks Stefan Unnasch Stephen Lasher 1 Novel Hydrogen Carriers Project Overview Cost Density (wt. and vol.) Energy requirements Forecourt storage requirements Codes and standards H H 2 2 Plant, Liquefier, LH Plant, Liquefier, LH 2 2 storage storage H H 2 2 Tube Trailer Tube Trailer LH 2 2 Tank/ Fueling Station LH Tank/ Fueling Station The efficient delivery of hydrogen is necessary for the adoption of hydrogen as a transportation fuel, but numerous challenges must be met. 2 "Conventional" delivery options are limited by volumetric density,

248

Fiber laser coupled optical spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

2008-03-04T23:59:59.000Z

249

Tissue-Specific Gene Delivery via Nanoparticle Coating  

E-Print Network [OSTI]

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

Harris, Todd J.

250

Suborbital freight delivery concept exploration  

SciTech Connect (OSTI)

Suborbital Freight, sometimes called Fast Freight, is delivery of high priority packages over intercontinental distances in periods of approximately one hour. The vehicles required are usually rocket-powered and have total ideal velocities of around 7.5 km/second. Analysis of this market indicates that there are niches where commercial operations are possible and might even be profitable using today{close_quote}s state-of-the-art technologies. The key requirements to capture this market are low nonrecurring costs, quick turnaround ({lt}9hours), and high reliability (0.999). This draft is a report on work in progress. The Fast Freight study will be completed before the STAIF-97 conference and results will be presented at that time. {copyright} {ital 1997 American Institute of Physics.}

Andrews, D.; Paris, S.; Rubeck, M. [Boeing Defense Space Group Seattle, Washington98124 (United States)

1997-01-01T23:59:59.000Z

251

Polarized internal target apparatus  

DOE Patents [OSTI]

A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

Holt, R.J.

1984-10-10T23:59:59.000Z

252

Polarized internal target apparatus  

DOE Patents [OSTI]

A polarized internal target apparatus with a polarized gas target of improved polarization and density achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms.

Holt, Roy J. (Downers Grove, IL)

1986-01-01T23:59:59.000Z

253

Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery and Delivery and Fueling (Text Alternative Version) to someone by E-mail Share Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Facebook Tweet about Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Twitter Bookmark Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Google Bookmark Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Delicious Rank Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Digg Find More places to share Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on AddThis.com... Publications Program Publications

254

Special Delivery for Sustainability: Clean Cities Supports UPS...  

Broader source: Energy.gov (indexed) [DOE]

Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding Natural Gas Operations Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding...

255

Energy-Efficient Melting and Direct Delivery of High Quality...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum itmdelivery.pdf More...

256

H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and...

257

Hydrogen Delivery R&D Activities | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

R&D Activities Hydrogen Delivery R&D Activities Hydrogen delivery technology may encompass several options over the short and long terms. The transportation and distribution...

258

Hydrogen Distribution and Delivery Fact Sheet | Department of...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Hydrogen Distribution and Delivery Fact Sheet Hydrogen Distribution and Delivery Fact Sheet Fact sheet produced by the Fuel Cell Technologies Office describing hydrogen...

259

Hydrogen Delivery Options and Issues | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Delivery Options and Issues Hydrogen Delivery Options and Issues Presentation by DOE's Mark Paster at the 2010 - 2025 Scenario Analysis for Hydrogen Fuel Cell Vehicles and...

260

Office of Electricity Delivery and Energy Reliability Recovery...  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability Recovery Program Plan Office of Electricity Delivery and Energy Reliability Recovery Program Plan Microsoft Word - OE PSRP June 5 2009...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Secretary of Energy Announces New Office of Electricity Delivery...  

Office of Environmental Management (EM)

New Office of Electricity Delivery & Energy Reliability Secretary of Energy Announces New Office of Electricity Delivery & Energy Reliability June 9, 2005 - 1:45pm Addthis...

262

Office of Electricity Delivery And Energy Reliability To Hold...  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy...

263

The Office of Electricity Delivery and Energy Reliability is...  

Broader source: Energy.gov (indexed) [DOE]

The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) The Office of Electricity Delivery and Energy Reliability is Closely...

264

Office of Electricity Delivery & Energy Reliability FY 2012 Budget...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation...

265

Office of Electricity Delivery and Energy Reliability Cyber Security...  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections On...

266

High power fiber delivery for laser ignition applications  

Science Journals Connector (OSTI)

The present contribution provides a concise review of high power fiber delivery research for laser ignition applications. The fiber delivery requirements are discussed in terms of exit...

Yalin, Azer P

2013-01-01T23:59:59.000Z

267

Magnetically attached sputter targets  

DOE Patents [OSTI]

An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

Makowiecki, D.M.; McKernan, M.A.

1994-02-15T23:59:59.000Z

268

Government Cuts Biofuels Targets  

Science Journals Connector (OSTI)

Government Cuts Biofuels Targets ... The Environmental Protection Agency has proposed lowering next year’s production targets for biofuels in the U.S. fuel mix—targets initially set in the Energy Independence & Security Act of 2007. ... Although the petroleum industry says the new targets still call for too much ethanol, biofuels advocates say changes to the Renewable Fuel Standard could kill the fledgling advanced biofuels industry. ...

MELODY BOMGARDNER; JEFF JOHNSON

2013-11-25T23:59:59.000Z

269

Fuel Cell Technologies Office Multi-Year Research, Development, and Demonstration Plan- Section 3.2 Hydrogen Delivery  

Broader source: Energy.gov [DOE]

Hydrogen Delivery technical plan section of the Fuel Cell Technologies Office Multi-Year Research, Development, and Demonstration Plan; updated October 2014. This plan includes goals, objectives, technical targets, tasks, and schedules for the Office of Energy Efficiency and Renewable Energy's contribution to the DOE Hydrogen and Fuel Cells Program.

270

High Power Cryogenic Targets  

SciTech Connect (OSTI)

The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

Gregory Smith

2011-08-01T23:59:59.000Z

271

Delivery and Receipt | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Delivery and Receipt Delivery and Receipt Delivery and Receipt Delivery and Receipt of Personal Property Acquired by Purchase Card at Headquarters Receiving Items Purchased with the Purchase Card that are Shipped or Delivered by the Vendor All personal property acquired by using the purchase card should generally be delivered to and processed by the receiving office (loading dock). This will ensure inventory control identification, as appropriate and recording in the personal property management records. The following practices and procedures, as set forth by the Personal Property and Supply Management Team, Office of Logistics and Facility Operations, Office of Administration, are effective November 2007. These procedures were implemented to create a safe work environment, reduce

272

Incorporating traffic patterns to improve delivery performance  

E-Print Network [OSTI]

Traffic, construction and other road hazards impact the on-time performance of companies that operate delivery fleets. This study examines how incorporating traffic patterns in vehicle route development compares with ...

Dickinson, Melody J

2010-01-01T23:59:59.000Z

273

Coordinated part delivery using distributed planning  

E-Print Network [OSTI]

In this thesis, we develop a distributed mobile robot platform to deliver parts around a model construction site. The platform's robots, specialized into delivery robots and assembly robots, use a distributed coverage ...

Bolger, Adrienne (Adrienne M.)

2010-01-01T23:59:59.000Z

274

PDGF-Receptor ?-Targeted Adenovirus Redirects Gene Transfer from Hepatocytes to Activated Stellate Cells  

Science Journals Connector (OSTI)

Department of Gastroenterology and Hepatology, Department of Therapeutic Gene Modulation, and Department of Pharmacokinetics and Drug Delivery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands ... Mailing address: Department of Therapeutic Gene Modulation, University of Groningen, Ant. ... Deusinglaan 1, 9713 AV Groningen, The Netherlands. ...

Marieke H. Schoemaker; Marianne G. Rots; Leonie Beljaars; Arjen Y. Ypma; Peter L. M. Jansen; Klaas Poelstra; Han Moshage; Hidde J. Haisma

2008-01-25T23:59:59.000Z

275

Low-Density Lipoprotein Reconstituted by Pyropheophorbide Cholesteryl Oleate as Target-Specific Photosensitizer  

Science Journals Connector (OSTI)

(6)?Shaw, J. M., Shaw, K. V., Yanovich, S., Iwanik, M., Futch, W. S., Rosowsky, A., and Schook, L. B. (1987) Delivery of lipophilic drugs using lipoproteins. ... Shaw, J. Michael; Shaw, Kala V.; Yanovich, Saul; Iwanik, Michael; Futch, William S.; Rosowsky, Andre; Schook, Lawrence B. ...

Gang Zheng; Hui Li; Min Zhang; Sissel Lund-Katz; Britton Chance; Jerry D. Glickson

2002-04-18T23:59:59.000Z

276

Status and EAC Recommendations for Electricity Delivery Workforce (September 2014)  

Broader source: Energy.gov [DOE]

Status and recommendations presented at the September 2014 meeting for Electricity Delivery Workforce (September 2014)

277

TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)  

SciTech Connect (OSTI)

The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition scheme is an essential component of an acceptably low-risk solution. The degree of coupling seen on NIF between driver and target performance mandates that little deviation be adopted from the NIF geometry and beamline characteristics. Similarly, the strong coupling between subsystems in an operational power plant mandates that a self-consistent solution be established via an integrated facility delivery project. The benefits of separability of the subsystems within an IFE plant (driver, chamber, targets, etc.) emerge in the operational phase of a power plant rather than in its developmental phase. An optimized roadmap for IFE delivery needs to account for this to avoid nugatory effort and inconsistent solutions. For LIFE, a system design has been established that could lead to an operating power plant by the mid-2020s, drawing from an integrated subsystem development program to demonstrate the required technology readiness on a time scale compatible with the construction plan. Much technical development work still remains, as does alignment of key stakeholder groups to this newly emerging development option. If the required timeline is to be met, then preparation of a viable program is required alongside the demonstration of ignition on NIF. This will enable timely analysis of the technical and economic case and establishment of the appropriate delivery partnership.

Dunne, A M

2010-11-30T23:59:59.000Z

278

Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target  

Science Journals Connector (OSTI)

...sum of an electrostatic solvation energy plus a nonpolar solvation energy. Entropic contributions to the binding free energy were estimated by calculating the...7 at 10 mumol/L was conducted by Ambit Biosciences (San Diego, CA) against...

Ariel Fernández; Angela Sanguino; Zhenghong Peng; Alejandro Crespo; Eylem Ozturk; Xi Zhang; Shimei Wang; William Bornmann; and Gabriel Lopez-Berestein

2007-05-01T23:59:59.000Z

279

Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target  

Science Journals Connector (OSTI)

...hallmarks of intrinsically disordered proteins. This combination...peptides and/or proteins do have specific features...They exist as dynamic ensembles within which atom...to recognize that disordered proteins are not incorrectly...

Ariel Fernández; Angela Sanguino; Zhenghong Peng; Alejandro Crespo; Eylem Ozturk; Xi Zhang; Shimei Wang; William Bornmann; and Gabriel Lopez-Berestein

2007-05-01T23:59:59.000Z

280

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure  

Science Journals Connector (OSTI)

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure ... The human brain is a uniquely complex organ, which has evolved a sophisticated protection system to prevent injury from external insults and toxins. ... Designing molecules that can overcome this protection system and achieve optimal concentration at the desired therapeutic target in the brain is a specific and major challenge for medicinal chemists working in CNS drug discovery. ...

Zoran Rankovic

2014-12-11T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Molecular mechanism of an adverse drug–drug interaction of allopurinol and furosemide in gout treatment  

Science Journals Connector (OSTI)

Abstract Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of gout patients is based on two further complementary mechanisms, the direct inhibition of XO activity by the allopurinol metabolite oxypurinol and a down-regulation of XO protein expression. The latter is compromised by addition of furosemide and might explain why patients receiving furosemide therapy require higher allopurinol doses. miR-448 was identified as a potential drug-dependent XO regulator. Finally, down-regulation of AMPK protein expression in HRCE cells by administration of oxypurinol/furosemide reveals a possible new mechanism of renal drug-induced hyperuricemia.

Claudia Knake; Lisa Stamp; Andrew Bahn

2014-01-01T23:59:59.000Z

282

Illicit drugs in the environment  

Science Journals Connector (OSTI)

...Nick Voulvoulis Illicit drugs in the environment Ettore Zuccato Sara Castiglioni...but risks for human health and the environment cannot be excluded. Morphine, cocaine...time. illicit drugs|drugs of abuse|environment|sewage treatment plant|wastewater...

2009-01-01T23:59:59.000Z

283

Advanced Target Effects Modeling  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

modeling of NDCX-II experiments include certain lower temper- ature effects, e.g., surface tension and target fragmentation, that are not generally present in extreme...

284

In the Target Area  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hohlraum This artist's rendering shows a NIF target pellet inside a hohlraum capsule with laser beams entering through openings on either end. The beams compress and heat the...

285

Purchase, Delivery, and Storage of Gases  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Purchase, Delivery, and Storage of Gases Print Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the ALS. See Shipping and Receiving for information on any non-gas deliveries. Contacts: Gas purchase or delivery: ALS Receiving, 510-486-4494 Gas use and storage: Experiment Coordination, 510-486-7222, This e-mail address is being protected from spambots. You need JavaScript enabled to view it Gas Storage: Berkeley Lab Chemical Inventory All gas bottles and cylinders at the ALS must be identified with bar code and logged into the Berkeley Lab Chemical Inventory by ALS staff. The inventory will be updated periodically; for more information contact Experiment Coordination. Gases are stored either in the racks between buildings 6 and 7; toxic and corrosive gases are stored in Building 6, room 6C across the walkway from beamline 10.0.

286

Neutron crystallography aids drug design  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Neutron crystallography aids drug design Neutron crystallography aids drug design Researchers have used neutron crystallography for the first time to determine the structure of a...

287

drug safety monitoring (DSM)  

Science Journals Connector (OSTI)

Active surveillance for drug safety (in contrast to spontaneous report system); active surveillance systems usually have higher response rates than “passive” systems such as the yellow card programme; ? see also

Dr. med. Dr. phil. Gerhard Nahler

2009-01-01T23:59:59.000Z

288

A systems approach to uncovering the adaptive response of cancer to targeted therapies  

E-Print Network [OSTI]

Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...

Randall, Adrian Joseph

2012-01-01T23:59:59.000Z

289

Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners  

E-Print Network [OSTI]

Background Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. Recent rapid progress in reactive metabolite target protein identification has shown ...

Hanzlik, Robert P.; Fang, Jianwen; Koen, Yakov M.

2009-06-12T23:59:59.000Z

290

Crucial stages of protein folding through a solvable model: Predicting target sites  

E-Print Network [OSTI]

Crucial stages of protein folding through a solvable model: Predicting target sites for enzyme. Keywords: Protein-folding modeling; prediction of key folding sites; HIV-1 protease; drug resistance One

Cecconi, Fabio

291

Career Opportunities in Biotechnology and Drug Developmentand Drug Development  

E-Print Network [OSTI]

Career Opportunities in Biotechnology and Drug Developmentand Drug Development Career Opportunities.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 1 #12-inflammatories www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development

Puglisi, Joseph

292

2012 Revenue for Delivery Service Providers  

U.S. Energy Information Administration (EIA) Indexed Site

Revenue for Delivery Service Providers" Revenue for Delivery Service Providers" "(Data from form EIA-861 schedule 4C)" ,,,"Revenue (Thousands Dollars)" "Entity","State","Ownership","Residential","Commercial","Industrial","Transportation","Total" "Pacific Gas & Electric Co","CA","Investor Owned",38657,306699,232366,2843,580565 "San Diego Gas & Electric Co","CA","Investor Owned",1019.1,62400.1,84143.3,0,147562.5 "Southern California Edison Co","CA","Investor Owned",6706,456007,69193,".",531906 "Connecticut Light & Power Co","CT","Investor Owned",362262,514043,100262,6681,983248

293

E-Print Network 3.0 - antimalarial drugs disrupt Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Enzyme FabI Plays a Summary: I is not the target of the antimalarial activity of triclosan, an inhibitor of bac- terial FabI. Disruption of fab... antimalarial drug that...

294

Postoperative Irradiation of Gynecologic Malignancies: Improving Treatment Delivery Using Aperture-Based Intensity-Modulated Radiotherapy  

SciTech Connect (OSTI)

Purpose: To evaluate dosimetric and treatment delivery advantages of aperture-based intensity-modulated radiotherapy (AB-IMRT) for the treatment of patients receiving whole pelvic radiotherapy for gynecologic malignancies. Methods and Materials: Nineteen patients undergoing pelvic radiotherapy after resection of endometrial cancers were selected. A 45-Gy dose was prescribed to the target volume delineated on a planning CT scan. An in-house inverse planning system, Ballista, was used to develop a treatment plan using aperture-based multileaf collimator segments. This approach was compared with conventional four-field, enlarged four-field, and static beamlet-based IMRT (BB-IMRT) techniques in terms of target coverage, dose-volume histogram statistics for surrounding normal tissues, and numbers of segments and monitor units (MU). Results: Three quarters (76.4%) of the planning target volume received the prescription dose with conventional four-field plans. With adequate target coverage, the Ballista plans significantly reduced the volume of bowel and bladder irradiated at the prescribed dose (p < 0.001), whereas the two approaches provided equivalent results for the rectum (p 0.5). On the other hand, AB-IMRT and BB-IMRT plans showed only small differences in dose-volume histogram statistics of unknown clinical impact, whereas Ballista plan delivery required on average 73% and 59% fewer segments and MU, respectively. Conclusion: With respect to conventional techniques, AB-IMRT for the treatment of gynecologic malignancies provides dosimetric advantages similar to those with BB-IMRT but with clear treatment delivery improvements.

Nadeau, Sylvain [Departement de physique, de genie physique et d'optique, Universite Laval, Quebec, QC (Canada) and Departement de radio-oncologie et Centre de recherche de l'Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada)]. E-mail: sylvainn@rrsb.nb.ca; Bouchard, Myriam [Departement de radio-oncologie et Centre de recherche de l'Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Germain, Isabelle [Departement de radio-oncologie et Centre de recherche de l'Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Raymond, Paul-Emile [Departement de radio-oncologie et Centre de recherche de l'Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Beaulieu, Frederic [Departement de radio-oncologie et Centre de recherche de l'Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Beaulieu, Luc [Departement de physique, de genie physique et d'optique, Universite Laval, Quebec, QC (Canada); Departement de radio-oncologie et Centre de recherche de l'Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Roy, Rene [Departement de physique, de genie physique et d'optique, Universite Laval, Quebec, QC (Canada); Gingras, Luc [Departement de physique, de genie physique et d'optique, Universite Laval, Quebec, QC (Canada); Departement de radio-oncologie et Centre de recherche de l'Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada)

2007-06-01T23:59:59.000Z

295

Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis  

Science Journals Connector (OSTI)

...review-article Minireview Energy Metabolism and Drug Efflux...of ATP. This suggests that energy metabolism and ATP production...treatment of XDR-TB patients in Argentina and is currently being used...bacterial targets involved in energy metabolism. These combinations...

Philippa A. Black; Robin M. Warren; Gail E. Louw; Paul D. van Helden; Thomas C. Victor; Bavesh D. Kana

2014-03-10T23:59:59.000Z

296

Tracking Mobile Units for Dependable Message Delivery  

E-Print Network [OSTI]

Tracking Mobile Units for Dependable Message Delivery Amy L. Murphy, Member, IEEE Computer Society at their disposal at any time, mobile computing is developing as an important research area. One of the fundamental problems in mobility is maintaining connectivity through message passing as the user moves through

Zhou, Yuanyuan

297

Modeling Delivery Delay for Flooding in Mobile  

E-Print Network [OSTI]

Modeling Delivery Delay for Flooding in Mobile Ad Hoc Networks TR-UTEDGE-2009-004 Taesoo Jun for Flooding in Mobile Ad Hoc Networks Taesoo Jun, Nirmalya Roy, and Christine Julien The Center for Excellence. In mobile networks, a major component of many of these routing protocols is some form of flooding, which

Julien, Christine

298

Hg Delivery System Vacuum 25 Oct 2005  

E-Print Network [OSTI]

. S. DEPARTMENT OF ENERGY V. Graves 25 Oct 2005 MERIT Mtg at MIT Oct 17-19 · During Hg delivery system to both design and operations #12;3 OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY V. Graves 25 & return lines - Sump tank & all connecting ports - Hg cylinder & bellows Hg inlet Hg cylinder & Bellows

McDonald, Kirk

299

Improvements to Hydrogen Delivery Scenario Analysis  

E-Print Network [OSTI]

­ Improved liquefier, pipeline, compressors, storage, labor, indirect capital, and O&M cost estimatesImprovements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad and storage are at or adjacent to Liquid Hydrogen (LH) TruckH2 Production 100 or 1500 kg/d Compressed H2 (CH

300

Cybersecurity Procurement Language for Energy Delivery (April 2014)  

Broader source: Energy.gov [DOE]

To assist with embedding cybersecurity in the procurement of energy delivery systems, this Cybersecurity Procurement Language for Energy Delivery Systems guidance document provides baseline cybersecurity procurement language for use by asset owners, operators, integrators, and suppliers during the procurement process.

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Colorado Natural Gas % of Total Residential Deliveries (Percent...  

Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

% of Total Residential Deliveries (Percent) Colorado Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

302

DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project...  

Broader source: Energy.gov (indexed) [DOE]

Delivery High-Pressure Tanks and Analysis Project Review Meeting DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting On February 8-9, 2005, the Department...

303

California Natural Gas Interstate Deliveries to All States (Million...  

U.S. Energy Information Administration (EIA) Indexed Site

Deliveries to All States (Million Cubic Feet) California Natural Gas Interstate Deliveries to All States (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5...

304

California Natural Gas % of Total Electric Utility Deliveries...  

U.S. Energy Information Administration (EIA) Indexed Site

Electric Utility Deliveries (Percent) California Natural Gas % of Total Electric Utility Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

305

Connecticut Natural Gas % of Total Residential Deliveries (Percent...  

U.S. Energy Information Administration (EIA) Indexed Site

% of Total Residential Deliveries (Percent) Connecticut Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7...

306

Cybersecurity for Energy Delivery Systems (CEDS) Peer Review...  

Broader source: Energy.gov (indexed) [DOE]

Peer Review August 5-7 Cybersecurity for Energy Delivery Systems (CEDS) Peer Review August 5-7 June 26, 2014 - 1:03pm Addthis The Office of Electricity Delivery and Energy...

307

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers,...

308

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia...

309

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry...

310

2012 Annual Planning Summary for Electricity Delivery and Energy Reliability  

Broader source: Energy.gov [DOE]

The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2012 and 2013 within Electricity Delivery and Energy Reliability.

311

Target | Open Energy Information  

Open Energy Info (EERE)

Target Target Jump to: navigation, search Name Target Address 1000 Nicollet Mall Place Minneapolis, MN Zip 55440 Website http://www.target.com Coordinates 44.9739366°, -93.2750493° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.9739366,"lon":-93.2750493,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

312

Photo-Targeted Nanoparticles  

Science Journals Connector (OSTI)

Photo-Targeted Nanoparticles ... The photo-dependent inhibition could be eliminated by prior addn. of glutathione or bisulfite to the irradiated soln. ... Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos ...

Tal Dvir; Matthew R. Banghart; Brian P. Timko; Robert Langer; Daniel S. Kohane

2009-11-11T23:59:59.000Z

313

DOE Hydrogen and Fuel Cells Program Record 12001: H2 Production and Delivery Cost Apportionment  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

01 Date: May 14, 2012 01 Date: May 14, 2012 Title: H 2 Production and Delivery Cost Apportionment Originator: Scott Weil, Sara Dillich, Fred Joseck, and Mark Ruth Approved by: Sunita Satyapal and Rick Farmer Date: December 14, 2012 Item: The hydrogen threshold cost is defined as the untaxed cost of hydrogen (H 2 ) (produced, delivered, and dispensed) at which hydrogen fuel cell electric vehicles (FCEVs) are projected to become competitive on a $/mile basis with competing vehicles [gasoline in hybrid-electric vehicles (HEVs)] in 2020. As established in Record 11007 [1], this cost ranges from $2.00-$4.00/gge a of H 2 (based on $2007). The threshold cost can be apportioned into its constituent H 2 production and delivery costs, which can then serve as the respective cost targets for multi-year planning of the Fuel Cell Technologies (FCT)

314

Energy Trade-offs among Content Delivery Architectures  

E-Print Network [OSTI]

Energy Trade-offs among Content Delivery Architectures Anja Feldmann Andreas Gladisch Mario Kind to incorporate var- ious home devices such as set-top boxes into content delivery architectures using the Peer-to-Peer (P2P) paradigm. The hope is to enhance the efficiency of content delivery, e.g., in terms

Smaragdakis, Georgios

315

Analysis of 9-tetrahydrocannabinol Driving Under the Influence of Drugs Cases in Colorado from January 2011 to February 2014  

Science Journals Connector (OSTI)

......profile (3, 4). Smoking is the most common route of marijuana administration as it provides rapid delivery of THC to the brain, quickly producing the desired effects of the drug. Peak effects of smoking are generally noted 20-30 min after use, with......

Sarah Urfer; Jaime Morton; Vanessa Beall; Jeanna Feldmann; Justin Gunesch

2014-10-01T23:59:59.000Z

316

Marketing of New Drugs  

Science Journals Connector (OSTI)

Marketing of New Drugs ... But there was no doubt an excess of expenditure for promotional purposes in recent years and the industry is gradually reducing this because the sales department cannot ask for the marketing of as many new products has it did in the past. ...

PAUL DE HAEN

1964-10-12T23:59:59.000Z

317

Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil  

Science Journals Connector (OSTI)

Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil ... The blood brain barrier (BBB) represents the biggest challenge for therapeutic drugs to enter the brain. ... In our study, we selected chlorambucil (CHL), an alkylating agent, as the model therapeutic agent, and used scopine as a novel brain-targeting moiety. ...

Xinyi Wang; Jianbo Li; Chaoqun Xu; Yanping Li; Tao Gong; Xun Sun; Yao Fu; Qin He; Zhirong Zhang

2014-10-28T23:59:59.000Z

318

College of Electricity Delivery and Energy Reliability | Department of  

Broader source: Energy.gov (indexed) [DOE]

Electricity Delivery and Energy Reliability Electricity Delivery and Energy Reliability College of Electricity Delivery and Energy Reliability College of Electricity Delivery and Energy Reliability Vision OE recognizes that our Nation's sustained economic prosperity, quality of life, and global competitiveness depend on access to an abundance of secure, reliable, and affordable energy resources. Through a mix of technology and policy solutions, we will address the changing dynamics and uncertainties in which the electric system will operate. We will leverage effective partnerships, solid research, and best practices to address diverse interests in achieving economic, societal, and environmental objectives. Resources Explore the following topics at OE's College of Electricity Delivery and Energy Reliability:

319

Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Ohio (Gas) - Residential Energy Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency Rebates Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency Rebates < Back Eligibility Construction Installer/Contractor Residential Savings Category Heating & Cooling Commercial Heating & Cooling Heating Home Weatherization Commercial Weatherization Sealing Your Home Ventilation Appliances & Electronics Water Heating Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Furnace: $150 - $275 Boiler: $300 Storage Water Heater: $125 Tankless Water Heater: $150 Programmable Thermostat: $20 Attic Insulation: Up to $600 Wall Insulation: Up to $700 Air Sealing: Up to $250 Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery offers residential natural gas customers in Ohio

320

Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer  

Science Journals Connector (OSTI)

...Fig. 2B and C). The lowest energy complex obtained from high-resolution...e., no cells are stained dark brown; left); a few TUNEL-positive...molecular target for cancer drug discovery. Oncogene 2000;19:6613-26...target for anticancer drug discovery. Recently, we developed a...

Naijie Jing; Qiqing Zhu; Ping Yuan; Yidong Li; Li Mao; and David J. Tweardy

2006-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Targeted delivery to PEPT1-overexpressing cells: Acidic, basic, and secondary floxuridine amino acid ester prodrugs  

Science Journals Connector (OSTI)

...were obtained on a 300 MHz Bruker DPX-300 NMR...Cells were grown in an atmosphere of 5 CO2 and 90 relative...Stability in Human Plasma. The stability of the prodrugs in human plasma was determined using...procedure below. Undiluted plasma (230 muL) was added...

Christopher P. Landowski; Balvinder S. Vig; Xueqin Song; and Gordon L. Amidon

2005-04-01T23:59:59.000Z

322

Targeted delivery to PEPT1-overexpressing cells: Acidic, basic, and secondary floxuridine amino acid ester prodrugs  

Science Journals Connector (OSTI)

...homogenates and slower in human plasma and were most chemically...were obtained on a 300 MHz Bruker DPX-300 NMR...Cells were grown in an atmosphere of 5 CO2 and 90 relative...Stability in Human Plasma. The stability of the prodrugs in human plasma was determined using...

Christopher P. Landowski; Balvinder S. Vig; Xueqin Song; and Gordon L. Amidon

2005-04-01T23:59:59.000Z

323

Abstract 380: Magnetic nanoplatforms for tumor targeting, imaging and energy delivery  

Science Journals Connector (OSTI)

...cancer cell lines. An inversion...high power field; P 0.0001...the sodium magnetic resonance...human cell lines (DU145...tumors at the magnetic field strength...are: MRI, magnetic resonance...high power field. Fig. 1...time. The lines are the theoretical...

Srinivas Sridhar; Robert Campbell; Dattatri Nagesha; and Evin Gultepe

2011-04-15T23:59:59.000Z

324

Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides  

Science Journals Connector (OSTI)

Here, we describe a nanocarrier system that can transfer chitosan nanoparticles loaded with either small peptides such as the caspase inhibitor Z-DEVD-FMK or a large peptide...

Secil Caban; Y?lmaz Capan; Patrick Couvreur; Turgay Dalkara

2012-01-01T23:59:59.000Z

325

Sustained delivery of siRNAs targeting viral infection by cell-degradable multilayered polyelectrolyte films  

Science Journals Connector (OSTI)

...reversed by a hyaluronidase inhibitor, suggesting that...hyaluronan (HA)-chitosan (CHI)/HA...2003 ) An NS3 protease inhibitor with antiviral effects in...behavior of acetylated chitosan porous beads . J Biomater...reversed by a hyaluronidase inhibitor, suggesting that...

Maria Dimitrova; Christine Affolter; Florent Meyer; Isabelle Nguyen; Doriane G. Richard; Catherine Schuster; Ralf Bartenschlager; Jean-Claude Voegel; Joëlle Ogier; Thomas F. Baumert

2008-01-01T23:59:59.000Z

326

Transepithelial transport of nanoparticles targeted to the neonatal Fc receptor for oral delivery applications  

E-Print Network [OSTI]

Nanoparticles (NPs) are poised to have a tremendous impact on the treatment of many diseases, but their broad application is limited because currently they can only be administered by parenteral methods. Oral administration ...

Pridgen, Eric M. (Eric Michael)

2013-01-01T23:59:59.000Z

327

Final Report - Hydrogen Delivery Infrastructure Options Analysis  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The Power of Experience The Power of Experience Final Report Hydrogen Delivery Infrastructure Options Analysis DOE Award Number: DE-FG36-05GO15032 Project director/principal investigator: Tan-Ping Chen Consortium/teaming Partners: Air Liquide, Chevron Technology Venture, Gas Technology Institute, NREL, Tiax, ANL Hydrogen Delivery Infrastructure Options Analysis ii TABLE OF CONTENTS SECTION 1 EXECUTIVE SUMMARY ........................................................................... 1-1 1.1 HOW THE RESEARCH ADDS TO THE UNDERSTANDING OF THE AREA INVESTIGATED. 1-1 1.2 TECHNICAL EFFECTIVENESS AND ECONOMIC FEASIBILITY OF THE METHODS OR TECHNIQUES INVESTIGATED OR DEMONSTRATED .................................................... 1-1 1.3 HOW THE PROJECT IS OF BENEFIT TO THE PUBLIC..................................................... 1-1

328

Roadmap to Achieve Energy Delivery Systems Cybersecurity  

Broader source: Energy.gov (indexed) [DOE]

Roadmap to Achieve Energy Delivery Systems Cybersecurity Roadmap to Achieve Energy Delivery Systems Cybersecurity ii Acknowledgements The Energy Sector Control Systems Working Group (ESCSWG) developed this roadmap in support of the Electricity Sub-sector Coordinating Council, Oil and Natural Gas Sector Coordinating Council, and the Government Coordinating Council for Energy under the Critical Infrastructure Partnership Advisory Council (CIPAC) Framework; the roadmap has been approved for release by these councils. The ESCSWG members volunteered their time and expertise to this effort and would like to thank the other participants for their valuable perspectives and contributions to this important effort. Special thanks go to the U.S. Department of Energy, which provided the funds and support needed to convene participants

329

Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

Comments of Cisco Systems to Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Department of Energy in Response to Request for Information: Addressing Policy and Logistical Challenges to Smart Grid Implementation Issued September 13, 2010 FR Doc. 2010-23251 November 30, 2010 Cisco Systems provides these Comments in response to the Request for Information ("RFI") issued by the Office of Electricity Delivery and Energy Reliability of the Department of Energy ("DOE") on September 13, 2010. The RFI seeks information across a broad range of topics, but also requests that commenters be "concise," and provide "facts and concrete recommendations that can augment the general knowledge." 1 1. Interoperability Standards and the Smart Grid

330

Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION  

Broader source: Energy.gov (indexed) [DOE]

2 2 Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION The Office of Electricity Delivery and Energy Reliability (OE) leads national efforts to modernize the electric grid, enhance security and reliability of energy infrastructure, and facilitate recovery from disruptions to the energy supply. As stated in the President's A Policy Framework for the 21 st Century Grid, a smarter, modernized electric grid is fundamental to transforming the Nation's energy system and securing US leadership in a clean energy future. OE supports activities that enable innovation across the energy sector, empower American consumers, and secure our energy future. OE consists of three programs: Research and Development; Permitting, Siting and Analysis; and Infrastructure Security and Energy Restoration.

331

Vulnerability Analysis of Energy Delivery Control Systems  

Broader source: Energy.gov (indexed) [DOE]

0-18381 0-18381 Vulnerability Analysis of Energy Delivery Control Systems September 2011 Idaho National Laboratory Idaho Falls, Idaho 83415 http://www.inl.gov Prepared for the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability Under DOE Idaho Operations Office Contract DE-AC07-05ID14517 The INL is a U.S. Department of Energy National Laboratory operated by Battelle Energy Alliance DISCLAIMER This information was prepared as an account of work sponsored by an agency of the U.S. Government. Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness, of any information, apparatus, product, or

332

Fiber Delivery of mid-IR lasers  

SciTech Connect (OSTI)

Fiber optics for the visible to near infrared (NIR) wavelength regimes (i.e. = 0.42 {mu}m) have proven to be extremely useful for a myriad of applications such as telecommunications, illumination, and sensors because they enable convenient, compact, and remote delivery of laser beams. Similarly, there is a need for fiber optics operating at longer wavelengths. For example, systems operating in the mid-IR regime (i.e., = 314 {mu}m) are being developed to detect trace molecular species with far-reaching applications, such as detecting explosives on surfaces, pollutants in the environment, and biomarkers in the breath of a patient. Furthermore, with the increasing availability of quantum cascade lasers (QCLs) which are semiconductor lasers that operate in the mid-IR regime additional uses are rapidly being developed. Here, we describe the development of hollow-core fibers for delivery of high-quality mid-IR laser beams across a broad spectral range.

Kriesel, J.M.; Gat, N.; Bernacki, Bruce E.; Myers, Tanya L.; Bledt, Carlos M.; Harrington, James P.

2011-08-24T23:59:59.000Z

333

DOE to Defer Strategic Petroleum Reserve RIK Deliveries | Department of  

Broader source: Energy.gov (indexed) [DOE]

to Defer Strategic Petroleum Reserve RIK Deliveries to Defer Strategic Petroleum Reserve RIK Deliveries DOE to Defer Strategic Petroleum Reserve RIK Deliveries June 5, 2008 - 12:51pm Addthis 2.1 Million Barrels Delayed Until Spring 2009 WASHINGTON, DC - The U. S. Department of Energy today announced it will defer approximately 2.1 million barrels of royalty-in-kind (RIK) exchange crude oil that had been scheduled for delivery to the nation's Strategic Petroleum Reserve sites (SPR) this summer. The deferred deliveries are part of a royalty-in-kind crude oil exchange that began in January 2008 and were to total approximately 11 million barrels delivered to the SPR through July 2008. The approximately 2.1 million barrels will be deferred for delivery until March-May 2009, after the winter heating season. Deliveries of approximately 2.8 million

334

Waste Feed Delivery Transfer System Analysis  

SciTech Connect (OSTI)

This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms.

JULYK, L.J.

2000-05-05T23:59:59.000Z

335

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer  

E-Print Network [OSTI]

Abstract Background The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This can only be achieved if the drug used is against a specific target...

Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

2011-05-28T23:59:59.000Z

336

Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA  

SciTech Connect (OSTI)

Apoferritin is a nanostructured material with a uniform size and spherical structure, and it has excellent bio-compatibility. In this work, we report the use of apoferritin as a novel and biocompatible carrier for stabilizing enzymes and their activities. We used glucose oxidase (GOx) as a model enzyme. GOx was immobilized on the surface of the apoferritin through a green synthetic approach taking advantage of bioaffinity binding between streptavidin and biotin. As a result, a glucose oxidase-biotin/streptavidin/biotin-apoferritin conjugate (Apo-GOx) was prepared using streptavidin as a bridge. The synthesized Apo-GOx was characterized with transmission electron microscopy, ultraviolet, and fluorescence spectroscopy. The activity and stability of GOx on the surface of the apoferritin were studied in different environments, such as temperature, chemicals, and pH, in comparison with the biotinylated GOx (B-GOx). The results showed that the activity of GOx on the apoferritin surface was significantly enhanced. The thermal and chemical stability of the GOx on the apoferritin was also greatly improved compared to free B-GOx in a solution. It was found that the activity of the GOx on the apoferritin only lost 30% in comparison to a 70% loss of free B-GOx after a 2-hr incubation at 50oC. There was almost no decrease in activity for the GOx on the apoferritin as compared to an 80% activity decrease for free B-GOx after 30 minutes of incubation in a 5 M urea solution. The GOx immobilized apoferritin nanoparticles exhibited high sensitivity for glucose detection with a detection limit of 3 nM glucose. This work offers a novel approach for immobilizing enzymes with enhanced stability and activity, and this method may find a number of applications, such as in catalysis and bioassys/biosensors.

Ma Ham, Aihui; Wu, Hong J.; Wang, Jun; Kang, Xinhuang; Zhang, Youyu; Lin, Yuehe

2011-05-11T23:59:59.000Z

337

Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery  

E-Print Network [OSTI]

Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ...

Bagby, Taryn Rochelle

2011-12-31T23:59:59.000Z

338

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery  

Science Journals Connector (OSTI)

Overwijk, W. W.; Theoret, M. R.; Finkelstein, S. E.; Surman, D. R.; de Jong, L. A.; Vyth-Dreese, F. A.; Dellemijn, T. A.; Antony, P. A.; Spiess, P. J.; Palmer, D. C. J. Exp. ... Overwijk, Willem W.; Theoret, Marc R.; Finkelstein, Steven E.; Surman, Deborah R.; de Jong, Laurina A.; Vyth-Dreese, Florry A.; Dellemijn, Trees A.; Antony, Paul A.; Spiess, Paul J.; Palmer, Douglas C.; Heimann, David M.; Klebanoff, Christopher A.; Yu, Zhiya; Hwang, Leroy N.; Feigenbaum, Lionel; Kruisbeek, Ada M.; Rosenberg, Steven A.; Restifo, Nicholas P. ...

Ronnie H. Fang; Che-Ming J. Hu; Brian T. Luk; Weiwei Gao; Jonathan A. Copp; Yiyin Tai; Derek E. O’Connor; Liangfang Zhang

2014-03-27T23:59:59.000Z

339

The evaluation of melamine dendrimers as potential macromolecular vehicles for anticancer drug delivery  

E-Print Network [OSTI]

.p. injections of 2.5-40 mg/kg of dendrimers were administered at 3 week intervals. Forty- eight hours following the last administration, blood chemistry worked revealed no renal * Reprinted from ?In vitro....p. injections of 2.5-40 mg/kg of dendrimers were administered at 3 week intervals. Forty- eight hours following the last administration, blood chemistry worked revealed no renal * Reprinted from ?In vitro...

Neerman, Michael Frederick

2005-08-29T23:59:59.000Z

340

Design, synthesis, and evaluation of dendrimers based on melamine as drug delivery vehicles  

E-Print Network [OSTI]

.1 Divergent and convergent synthetic routes to dendrimers .......................... 2 1.2 Architecture of dendrimers: (a) PPI; (b) PAMAM; (c) polyester; (d) triazine-based dendrimer... 3.9 Post-PET biodistribution data of a 124 I-labeled dendrimer (~17 kDa) in nude mice with PC-3-Luc xenografts at 48 h post-injection .................. 41 4.1 1 H NMR assignment and integration of 2 in the expanded region 4.8 to 8.2 ppm...

Lim, Jong Doo

2009-05-15T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Fabrication of Metal/Oxide Nanostructures by Anodization Processes for Biosensor, Drug Delivery and Supercapacitor Applications  

E-Print Network [OSTI]

applications of micro/nano structures; (2) novel processes to innovate anodic aluminum oxide nanotube template; (3) the supercapacitor applications of anodic titanium oxide. First, the extremely high surface area AAO coated microneedle and microneedle array...

Chen, Po-Chun

2014-01-13T23:59:59.000Z

342

Mucoadhesive Sustained Drug Delivery System Based on Cationic Polymer and Anionic Cyclodextrin/Triclosan Complex  

Science Journals Connector (OSTI)

In this study the interactions between a cationic polymer and an anionic cyclodextrin were investigated. The system has the potential for use in a sustained release dosage forms for use on mucous membranes. As mu...

Hakon H. Sigurdsson; Elin Knudsen…

2002-12-01T23:59:59.000Z

343

A novel method for the preparation of biodegradable microspheres for protein drug delivery  

Science Journals Connector (OSTI)

...glucose, i.e. linear amylase and branched amylopectin (Young 1984). Starch...release from poly(alpha-hydroxy acid) microspheres...properties of substituted amylase matrices. Int. J...Marchessault1998Cross-linked high amylose starch for controlled...

2006-01-01T23:59:59.000Z

344

Carbon nanostructures as multi-functional drug delivery Rafael G. Mendes,a  

E-Print Network [OSTI]

the various properties of carbon nanostructures that allow such multi-functionality. Recent advances then worked as a Research Fellow at the German Aerospace Center (DLR) at the Institute of Space Sensor Tech- structures, in particular carbon based nanomaterials, as well as advanced techniques

Cuniberti, Gianaurelio

345

A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release  

E-Print Network [OSTI]

localization of therapeutic compounds than is possible with existing technology. Despite recent advance- ments release Aram J. Chung & Yun Suk Huh & David Erickson Published online: 8 April 2009 # Springer Science the survival rate in porcine cases and more recently Krismer et al. (2005) reported for human as well

Erickson, David

346

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds  

Science Journals Connector (OSTI)

...hospitalized monitoring (Price et al. 1996; Somayaji...step usually includes heating, which, even if...technique (water/oil/water). PLGA...without external heating. The compaction procedure...0885328204043200 ) Price, J. S. , A. F...

2010-01-01T23:59:59.000Z

347

A Bi-Mix Antibacterial Drug-Delivery System for Regenerative Endodontics. Jadesada Palasuk1  

E-Print Network [OSTI]

), Kruskal-Wallis and Mann-Whitney tests were performed (=0.05). The results showed that uniaxial tensile

Zhou, Yaoqi

348

Abstract B40: Injectable multifunctional biodegradable polymeric microspheres for localized drug delivery in breast cancer treatment  

Science Journals Connector (OSTI)

...Abstracts: Sixth AACR Conference: The Science of Cancer Health Disparities; December...Uhrich 5 Wei Yue 5 1African University of Science and Technology, Abuja, Fct-Abuja...2Princeton University, Princeton, NJ, 3Sheda Science and Technology Complex (SHESTCO), Abuja...

John David Obayemi; Winston Oluwole Soboyejo; Olushola S. Odusanya; Nicolas Anuku; Kathryn E. Uhrich; Wei Yue

2014-11-01T23:59:59.000Z

349

pH-sensitive core-shell nanoparticles for intracellular drug delivery  

E-Print Network [OSTI]

Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis ...

Hu, Yuhua, Ph. D. Massachusetts Institute of Technology

2008-01-01T23:59:59.000Z

350

Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites  

E-Print Network [OSTI]

Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureMichael J. Engineering the chemistry and nanostructure of

Perelman, Loren Avery

2008-01-01T23:59:59.000Z

351

Chemically modified and nanostructured porous silicon as a drug delivery material and device  

E-Print Network [OSTI]

Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructure

Anglin, Emily Jessica

2007-01-01T23:59:59.000Z

352

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds  

Science Journals Connector (OSTI)

...need for hospitalized monitoring (Price et al. 1996; Somayaji et al. 1998...freeze-drying and desiccation at 37C. Poly(ethylene glycol) (PEG) was included in the...doi:10.1177/0885328204043200 ) Price, J. S. , A. F. Tencer, D. M...

2010-01-01T23:59:59.000Z

353

Refactored M13 Bacteriophage as a Platform for Tumor Cell Imaging and Drug Delivery  

E-Print Network [OSTI]

M13 bacteriophage is a well-characterized platform for peptide display. The utility of the M13 display platform is derived from the ability to encode phage protein fusions with display peptides at the genomic level. However, ...

Ghosh, Debadyuti

354

Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery  

Science Journals Connector (OSTI)

...promote the bone regeneration process. mesoporous bioceramics...accelerating the healing process. Thus, the design, development and commercialization of bioactive and biodegradable...elements play key roles in the processes that promote bone formation...

2012-01-01T23:59:59.000Z

355

Utah-Inha Joint Research Center on Drug Delivery Systems & Advanced Therapeutics  

E-Print Network [OSTI]

Theranostics for cancer #12;7 Why Korea? Korea has a well-trained technical workforce with modern biomedical

Tipple, Brett

356

Theoretical and experimental investigations of passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network [OSTI]

In the initial investigation of this thesis, Fick's second law of diffusion was modified to describe both the transient, and the steady-state, transdermal transport of hydrophilic permeants through unbranched, aqueous pore ...

Kushner, Joseph, IV

2007-01-01T23:59:59.000Z

357

Water-soluble carbon nanotube compositions for drug delivery and medicinal applications  

DOE Patents [OSTI]

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

2014-07-22T23:59:59.000Z

358

Applications of single molecule and nanoparticle imaging in chemical separation, photocatalysis, and drug delivery.  

E-Print Network [OSTI]

??This dissertation includes five chapters. Chapter 1 introduces single molecule and nanoparticle imaging techniques and their applications. Chapter 2 is a study of electrophoretic migration… (more)

Han, Rui

2014-01-01T23:59:59.000Z

359

Bioadhesive PAA-PEG-PAA triblock copolymer hydrogels for drug delivery in oral cavity  

Science Journals Connector (OSTI)

A series of poly(amidoamine)-poly(ethylene glycol)-poly(amidoamine) (PAA-PEG-PAA) triblock copolymers were designed and prepared to...1H NMR spectroscopy and gel permeation chromatography. The PAA-PEG-PAA copolym...

Minh Khanh Nguyen; Doo Sung Lee

2010-03-01T23:59:59.000Z

360

Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery  

E-Print Network [OSTI]

vi LIST OF FIGURES FIGURE Page 1 First generation dendrimer transfection- n/p 7.5. 30,000 cells / well were plated ...................................................................................................................... 8 2 Second... with either dried or liquid dendrimer. Treatment of wells with dried dendrimer was as follows: two dendrimers (F2-1 and G2- 5) of varying concentrations (n/p 5, n/p 7.5, n/p 10) were dried in a separate plate. OptiMEM and DNA were added to each well...

Snow, Merideth

2010-07-14T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Waste feed delivery planning at Hanford  

SciTech Connect (OSTI)

The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

2013-01-10T23:59:59.000Z

362

Waste Feed Delivery Planning at Hanford - 13232  

SciTech Connect (OSTI)

The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades. (authors)

Certa, Paul J.; Hohl, Ted M.; Kelly, James W.; Larsen, Douglas C.; West, Elizha B.; Ritari, Jaakob S.; Rodriguez, Juissepp S. [Washington River Protection Solutions, LLC, P.O. 850, Richland, WA 99352 (United States)] [Washington River Protection Solutions, LLC, P.O. 850, Richland, WA 99352 (United States)

2013-07-01T23:59:59.000Z

363

Candidate Radiation Drugs Inch Forward  

Science Journals Connector (OSTI)

Candidate Radiation Drugs Inch Forward 10.1126/science.331.6024...radiation, workers at the damaged Fukushima nuclear plant wear protective gear...Candidate radiation drugs inch forward. | News | 0 (E)-4-carboxystyryl-4-chlorobenzylsulfone...

Yudhijit Bhattacharjee

2011-03-25T23:59:59.000Z

364

Foam encapsulated targets  

DOE Patents [OSTI]

Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

1983-01-01T23:59:59.000Z

365

Targeted radionuclide therapy  

SciTech Connect (OSTI)

Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

2008-07-15T23:59:59.000Z

366

TRANSFORMED DSM TARGETS GROWTH  

Science Journals Connector (OSTI)

TRANSFORMED DSM TARGETS GROWTH ... DSM CHIEF Executive Officer Feike Sijbesma refers to Charles Darwin when talking about his company’s transformation. ... In the past 10 years, DSM has transformed itself, shifting its portfolio from petrochemicals and specialties to life sciences and materials. ...

PAIGE MARIE MORSE

2011-03-14T23:59:59.000Z

367

Drug Testing for DOE Positions | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact...

368

H2A Delivery Scenario Model and Analyses  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

H2A Delivery Scenario Model H2A Delivery Scenario Model and Analyses Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office of Science U.S. Department of Energy Topics * Delivery Scenarios - Current status - Future scenarios * Delivery Scenarios model - Approach - Structure - Current status - Results * Pipeline modeling - Approach - Key assumptions - Results * Next Steps 3 Pioneering Science and Technology Office of Science U.S. Department of Energy Delivery Scenarios 4 Pioneering Science and Technology Office of Science U.S. Department of Energy Three-Quarters of the US Population Reside in Urbanized Areas East of the Mississippi there are many large, proximate urban areas. In the West

369

Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of  

Broader source: Energy.gov (indexed) [DOE]

Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. The final agenda and welcome presentation are below. Presentations

370

Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of  

Broader source: Energy.gov (indexed) [DOE]

Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. The final agenda and welcome presentation are below. Presentations

371

Microsoft Word - LCC-0135 Machine Protection Issues in the Beam Delivery System.doc  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

5 5 SLAC-TN-04-039 November 2003 Abstract This note documents a set of expressions used to explore the issue of whether or not it is reasonable to consider a conventional positron source for a Tesla formatted beam. The critical issue is that of energy deposition in the conversion target and the comparison of the induced stress with the ultimate tensile strength of the target material. Since the length of the incident beam pulse is large in comparison to the ratio of beam size to the speed of sound, the concurrent pressure pulse dissipates in a time short compared to the overall pulse duration and one is left with only the Machine Protection Issues in the Beam Delivery System L. Keller and T. Markiewicz Stanford Linear Accelerator Center

372

Materials Solutions for Hydrogen Delivery in Pipelines  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Solutions for Solutions for Hydrogen Delivery in Pipelines Dr. Subodh K. Das Secat, Inc. September 26, 2007 This presentation does not contain any proprietary, confidential, or otherwise restricted information Project Team SECAT (KY) Project Manager Oregon Steel Mills (OR) Steel Pipe Producer Columbia Gas of Kentucky (KY) NG transporter Schott North America (PA) Glass coatings supplier Chemical Composite Coatings (GA) Composites coatings Advanced Technology Corp. (TN) ABI technology provider ASME (NY) Codes and Standards DGS Metallurgical Solutions (OR) Steel consulting University of Illinois (IL) Basic embrittlement studies Oak Ridge National Laboratory (TN) Applied research Objective and Deliverables Objective: ∑ Develop materials technologies to minimize embrittlement of

373

Apparatus for forming targets  

DOE Patents [OSTI]

Apparatus and method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

Woerner, Robert L. (Livermore, CA)

1980-01-01T23:59:59.000Z

374

Near-Infrared Optical Imaging of B16 Melanoma Cells via Low-Density Lipoprotein-Mediated Uptake and Delivery of High Emission Dipole Strength Tris[(porphinato)zinc(II)] Fluorophores  

Science Journals Connector (OSTI)

Shaw, J. M., Shaw, K. V., Yanovich, S., Iwanik, M., Futch, W. S., Rosowsky, A., and Schook, L. B. (1987) Delivery of lipophilic drugs using lipoproteins. ... Shaw, J. Michael; Shaw, Kala V.; Yanovich, Saul; Iwanik, Michael; Futch, William S.; Rosowsky, Andre; Schook, Lawrence B. ...

Sophia P. Wu; Intae Lee; P. Peter Ghoroghchian; Paul R. Frail; Gang Zheng; Jerry D. Glickson; Michael J. Therien

2005-04-30T23:59:59.000Z

375

Hydrogen Delivery InfrastructureHydrogen Delivery Infrastructure Option AnalysisOption Analysis  

E-Print Network [OSTI]

Converting NG/oil pipelines for GH delivery Option 3 Blending GH into NG pipelines Option 4* GH tube trailers Option 5* LH tank trucks Option 6 Use of novel H2 carriers (alanate; chemical hydride; liquid hydrocarbon as CA) -- NG distribution lines: gas companies usually use for Class 3 & 4 No odorants used in current H

376

Drug Therapy: Alzheimer's Disease  

Science Journals Connector (OSTI)

...provide evidence supporting the concept that vitamin E, as well as vitamin C, has a role in delaying the onset of Alzheimer's disease.– Memantine. Memantine, an N-methyl-D-aspartate antagonist recently approved by the Food and Drug Administration (FDA) for the treatment of moderate-to-severe Alzheimer's... The prevalence of Alzheimer's disease is predicted to reach 13.2 million cases in the United States. This article considers current therapeutic approaches for Alzheimer's disease. Optimal management requires accurate diagnosis, which is increasingly based on an understanding of pathophysiology. Neuroprotective strategies, cholinesterase inhibitors, psychopharmacologic agents that may reduce behavioral disturbances, and newer agents such as memantine are discussed.

Cummings J.L.

2004-07-01T23:59:59.000Z

377

Heteromultivalent ligand-decoration for actively targeted nanomedicine  

Science Journals Connector (OSTI)

Abstract Active targeting has become an important component of nanomedicine design where nanovehicles are surface-decorated with cell receptor-specific or disease matrix-specific ligands to enable site-selective binding, retention and delivery of theranostic cargo. In this context, there have been numerous reports regarding surface-modification of nanovehicles with antibodies, antibody fragments, carbohydrates, aptamers and peptides as targeting ligands. However, majority of these reports have focused on using a single type of targeting moiety on the vehicle surface. In any disease development and progression, multiple receptors and proteins are often spatio-temporally upregulated simultaneously and heterogeneously. Rationalizing from this, a significant advantage can be envisioned in targeting multiple entities simultaneously using vehicle co-decoration with multiple types of ligands, to enhance binding activity and targeting specificity. To this end, we present a comprehensive up-to-date review on research endeavors in heteromultivalent ligand-modification of nanovehicles and provide a mechanistic rationale as well as an insightful discussion of this promising area, including findings from our own research.

Christa L. Modery-Pawlowski; Anirban Sen Gupta

2014-01-01T23:59:59.000Z

378

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Software Engineering Institute Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations from Carnegie Mellon University's Software Engineering

379

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Visualization and Modeling Visualization and Modeling Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Visualization and Modeling are below.

380

Examination of Terminal Land Requirements for Hydrogen Delivery  

Broader source: Energy.gov [DOE]

Presentation by Jerry Gillette of Argonne National Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

H2A Delivery Components Model and Analysis  

Broader source: Energy.gov (indexed) [DOE]

Hydrogen Delivery Components Model Matt Ringer National Renewable Energy Laboratory February 8, 2005 Other Team Members: Mark Paster: DOE Marianne Mintz, Jerry Gillette, Jay Burke:...

382

H2A Delivery Scenario Model and Analyses  

Broader source: Energy.gov (indexed) [DOE]

Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office...

383

H2A Delivery: Miscellaneous Cost and H2 Losses  

Broader source: Energy.gov [DOE]

Presentation by Matt Ringer of the National Renewable Energy Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

384

H2A Delivery: Forecourt Compression & Storage Optimization (Part II)  

Broader source: Energy.gov [DOE]

Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

385

,"North Carolina Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","North Carolina Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

386

,"South Dakota Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","South Dakota Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

387

,"North Dakota Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","North Dakota Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

388

,"New Hampshire Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","New Hampshire Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

389

,"Rhode Island Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","Rhode Island Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

390

,"New Jersey Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","New Jersey Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

391

,"West Virginia Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

Of Series","Frequency","Latest Data for" ,"Data 1","West Virginia Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","112014" ,"Release...

392

Massachusetts Save Energy Now—State, Local, and Regional Delivery  

Broader source: Energy.gov [DOE]

Massachusetts Save Energy Now—State, Local, and Regional Delivery captures lost energy efficiency implementation by offering trainings, technical assistance, and information to industrial companies within the region.

393

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery...  

Broader source: Energy.gov (indexed) [DOE]

Bulk Hydrogen Storage Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Breakout Session - Bulk Hydrogen Storage Main ThemesCaveats Bulk...

394

Office of Electricity Delivery and Energy Reliability | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Office of Electricity Delivery and Energy Reliability Community Guidelines for Energy Emergencies Community Guidelines for Energy Emergencies Read more Smart Grid Investments...

395

Percentage of Total Natural Gas Industrial Deliveries included...  

U.S. Energy Information Administration (EIA) Indexed Site

Industrial Price Percentage of Total Industrial Deliveries included in Prices Vehicle Fuel Price Electric Power Price Period: Monthly Annual Download Series History Download...

396

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the Power Grid (TCIPG)...

397

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Practice DesignConfiguration Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practice DesignConfiguration National lab researchers, industry...

398

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Broader source: Energy.gov (indexed) [DOE]

Visualization and Modeling Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and...

399

Hydrogen Delivery Technologies and Systems- Pipeline Transmission of Hydrogen  

Broader source: Energy.gov [DOE]

Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen. Design and operations standards and materials for hydrogen and natural gas pipelines.

400

NREL: Hydrogen and Fuel Cells Research - Hydrogen Production and Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hydrogen Production and Delivery Hydrogen Production and Delivery Most of the hydrogen in the United States is produced by steam reforming of natural gas. For the near term, this production method will continue to dominate. Researchers at NREL are developing advanced processes to produce hydrogen economically from sustainable resources. NREL's hydrogen production and delivery R&D efforts, which are led by Huyen Dinh, focus on the following topics: Biological Water Splitting Fermentation Conversion of Biomass and Wastes Photoelectrochemical Water Splitting Solar Thermal Water Splitting Renewable Electrolysis Hydrogen Dispenser Hose Reliability Hydrogen Production and Delivery Pathway Analysis. Biological Water Splitting Certain photosynthetic microbes use light energy to produce hydrogen from

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

An Unusual Mechanism for the Antimicrobial Target Flavine-dependant  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

An Unusual Mechanism for the Antimicrobial An Unusual Mechanism for the Antimicrobial Target Flavine-dependant Thymidylate Synthase (FTDS) Classical thymidylate synthases, encoded by the thyA and TYMS genes, are present in most eukaryotes, including humans, and are frequently targeted by chemotherapeutic and antibiotic drugs. A recently discovered class of thymidylate synthases, the FDTSs encoded by the thyX gene has been found primarily in prokaryotes and viruses including several pathogens and biological warfare agents (see http://www.cdc.gov). Several organisms, including human pathogens, rely solely on thyX for thymidylate synthesis. FDTSs share no structure or sequence homology with classical thymidylate synthases (Fig 1), and thus present a promising new frontier for antibacterial/antiviral drug development.

402

Targeting Cancer More Effectively CR@B brings together researchers from across the University and the Royal United Hospital, Bath.  

E-Print Network [OSTI]

Targeting Cancer More Effectively CR@B brings together researchers from across the University to find a cure for various types of cancer. 40 academic groups from nearly every department to bedside and back again. Drug Discovery The discovery of a new family of anti-cancer drugs called steroid

Burton, Geoffrey R.

403

In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27  

Science Journals Connector (OSTI)

New features of an antiprotozoal DNA minor-groove binding drug, which acts as a cross-linking agent, are presented. It also fills the minor groove of DNA completely and prevents the access of proteins. These features are also expected for other minor-groove binding drugs when associated with suitable DNA targets.

Acosta-Reyes, F.J.

2014-05-24T23:59:59.000Z

404

A planning and delivery study of a rotational IMRT technique with burst delivery  

SciTech Connect (OSTI)

Purpose: A novel rotational IMRT (rIMRT) technique using burst delivery (continuous gantry rotation with beam off during MLC repositioning) is investigated. The authors evaluate the plan quality and delivery efficiency and accuracy of this dynamic technique with a conventional flat 6 MV photon beam. Methods: Burst-delivery rIMRT was implemented in a planning system and delivered with a 160-MLC linac. Ten rIMRT plans were generated for five anonymized patient cases encompassing head and neck, brain, prostate, and prone breast. All plans were analyzed retrospectively and not used for treatment. Among the varied plan parameters were the number of optimization points, number of arcs, gantry speed, and gantry angle range (alpha) over which the beam is turned on at each optimization point. Combined rotational/step-and-shoot rIMRT plans were also created by superimposing multiple-segment static fields at several optimization points. The rIMRT trial plans were compared with each other and with plans generated using helical tomotherapy and VMAT. Burst-mode rotational IMRT plans were delivered and verified using a diode array, ionization chambers, thermoluminescent dosimeters, and film. Results: Burst-mode rIMRT can achieve plan quality comparable to helical tomotherapy, while the former may lead to slightly better OAR sparing for certain cases and the latter generally achieves slightly lower hot spots. Few instances were found in which increasing the number of optimization points above 36, or superimposing step-and-shoot IMRT segments, led to statistically significant improvements in OAR sparing. Using an additional rIMRT partial arc yielded substantial OAR dose improvements for the brain case. Measured doses from the rIMRT plan delivery were within 4% of the plan calculation in low dose gradient regions. Delivery time range was 228-375 s for single-arc rIMRT 200-cGy prescription with a 300 MU/min dose rate, comparable to tomotherapy and VMAT. Conclusions: Rotational IMRT with burst delivery, whether combined with static fields or not, yields clinically acceptable and deliverable treatment plans.

Kainz, Kristofer; Chen, Guang-Pei; Chang, Yu-Wen; Prah, Douglas; Sharon Qi, X.; Shukla, Himanshu P.; Stahl, Johannes; Allen Li, X. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States); Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado 80045 (United States); Siemens Oncology Care Systems, Concord, California 94520 (United States); Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States)

2011-09-15T23:59:59.000Z

405

Rotating Target Development for SNS Second Target Station  

SciTech Connect (OSTI)

A rotating target for the second target station (STS) at SNS has been identified as an option along with a mercury target. Evaluation of the rotating target alternative for STS has started at 1.5 MW which is considered an upper bound for the power. Previous preconceptual design work for a 3 MW rotating target is being modified for the lower power level. Transient thermal analysis for a total loss of active water cooling has been done for a simplified 2D model of the target and shielding monolith which shows that peak temperatures are well below the level at which tungsten vaporization by steam could exceed site boundary dose limits. Design analysis and integration configuration studies have been done for the target-moderator-reflector assembly which maximizes the number of neutron beam lines and provides for replacement of the target and moderators. Target building hot cell arrangement for this option will be described. An option for operation in rough vacuum without a proton beam window using Ferro fluid seals on a vertical shaft is being developed. A full scale prototypic drive module based on the 3 MW preconceptual design has been fabricated and successfully tested with a shaft and mock up target supplied by the ESS-Bilbao team. Overall planning leading to decision between mercury and the rotating target in 2011 will be discussed

McManamy, Thomas J [ORNL; Rennich, Mark J [ORNL; Crawford, Roy K [ORNL; Geoghegan, Patrick J [ORNL; Janney, Jim G [ORNL

2010-01-01T23:59:59.000Z

406

Drug Detection Study  

Office of Scientific and Technical Information (OSTI)

ORISE-07-NSEM-0544 ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge Institute for Science and Education Operated by Oak Ridge Associated Universities For the U.S. Department of Energy Oak Ridge Associated Universities (ORAU) is a university consortium leveraging the scientific strength of major research institutions to advance science and education by partnering with national laboratories, government agencies, and private industry. ORAU manages the Oak Ridge Institute for Science and Education for the U.S. Department of Energy. The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy institute focusing on

407

Timely Delivery of Laser Inertial Fusion Energy Presentation prepared for  

E-Print Network [OSTI]

plant design · Delivery soon enough to make a difference to global energy imperatives. · Design basedTimely Delivery of Laser Inertial Fusion Energy Presentation prepared for Town Hall meeting must directly address the end-user requirement for commercial power 3 Plant Primary Criteria (partial

408

CIB White Paper on IDDS Integrated Design & Delivery Solutions  

E-Print Network [OSTI]

CIB White Paper on IDDS Integrated Design & Delivery Solutions Publication 328 ISBN 978-90-6363-060-7 #12;CIB White Paper on IDDS Page 1 of 15 CIB White Paper on IDDS Integrated Design & Delivery White Paper on IDDS Page 2 of 15 Table of Contents Introduction and Use of this White Paper

Amor, Robert

409

Office of Electricity Delivery &amp; Energy Reliability Contributors |  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery & Energy Reliability » Office of Office of Electricity Delivery & Energy Reliability » Office of Electricity Delivery & Energy Reliability Contributors Office of Electricity Delivery & Energy Reliability Contributors June 20, 2012 David Ortiz, OE-40 David Ortiz is Deputy Assistant Secretary for Energy Infrastructure Modeling and Analysis (EIMA) in the Department of Energy's Office of Electrici April 25, 2013 Eric Lightner June 22, 2011 Henry S. Kenchington, OE-50 Mr. Henry (Hank) Kenchington is Deputy Assistant Secretary (DAS) for the Advanced Grid Integration Division in the Department of Energy's Office of Electricity Delivery and Energy Reliability. He is responsible for the strategic management of the $3.4 billion Smart Grid Investment Grant program funded under the American Recovery and Reinvestment Act of 2009 to

410

National Electricity Delivery Division (NEDD) | Department of Energy  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) Timely, accurate and defensible policy and market analysis is a key ingredient to building and sustaining successful programs at DOE. The National Electricity Delivery Division coordinates OE's policy-related activities which include: Coordination of Federal Transmission Authorizations Section 1221(a) of EPACT added section 216(h) to the Federal Power Act, which requires that DOE act as the lead agency for purposes of coordinating all applicable Federal authorizations and related environmental reviews required to site an electric transmission facility. DOE and eight other Federal agencies have entered into a Memorandum of Understanding and DOE

411

Hydrogen Delivery: An Option to Ease the Transition  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery: Delivery: An Option to Ease the Transition Presentation at: The DOE Hydrogen and Fuel Cells Coordination Meeting Washington, D.C. June 3, 2003 John C. Winslow, Product Manager, Coal Fuels & Hydrogen National Energy Technology Laboratory Descriptor - include initials, /org#/date Hydrogen Delivery Today * Hydrogen infrastructure exists only for small merchant hydrogen markets in the chemical and refining industries * Current natural gas infrastructure consists of: - Pipelines - intermediate product storage - import terminals - rail, barge, and truck delivery U.S. Pipeline Mileage 0.7 2000 279 0 1000 2000 3000 Oil Nat Gas Hydrogen thousand miles Source: APCI, EIA, NEP Descriptor - include initials, /org#/date Comparison of Alternative Delivery Pathways Central H 2 production (coal)

412

Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Indiana (Gas) - Residential Energy Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency Rebates Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency Rebates < Back Eligibility Construction Residential Savings Category Heating & Cooling Commercial Heating & Cooling Heating Home Weatherization Commercial Weatherization Sealing Your Home Ventilation Program Info State Indiana Program Type Utility Rebate Program Rebate Amount Attic Insulation: 40% of cost, up to $450 Wall/Ceiling Insulation: 40% of cost, up to $450 Duct Sealing: Total cost, up to $400 Boilers: $300 Furnace: $150 - $275 Programmable Thermostat: $20 Provider Vectren Energy Delivery of Indiana Vectren Energy Delivery offers its residential natural gas customers in Indiana rebates for the installation of certain high efficiency natural gas

413

Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate |  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate < Back Eligibility Construction Installer/Contractor Residential Savings Category Heating & Cooling Home Weatherization Construction Commercial Weatherization Commercial Heating & Cooling Design & Remodeling Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Full Adoption of Energy Star (Version 2.5) Standards: $750 Vectren Gold Star - HERS rating of 70 or less: $750 Furnace: $300 Boiler: $500 Tankless Water Heater: $150 Storage Water Heater: $50-$150 Programmable Thermostat: $20 Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery of Ohio offers a flat rebate to builders of residential single-family Energy Star certified homes that receive gas

414

Optical diagnostics integrated with laser spark delivery system  

DOE Patents [OSTI]

A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

2008-09-02T23:59:59.000Z

415

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

Electricity Electricity Delivery and Energy Reliability Categorical Exclusion Determinations: Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations issued by Electricity Delivery and Energy Reliability. DOCUMENTS AVAILABLE FOR DOWNLOAD September 18, 2012 CX-009236: Categorical Exclusion Determination Dynasty Power, Inc. Export Authorization CX(s) Applied: B4.2 Date: 09/18/2012 Location(s): Canada Offices(s): Electricity Delivery and Energy Reliability September 18, 2012 CX-009406: Categorical Exclusion Determination Rainbow Energy Marketing Corporation CX(s) Applied: B4.2 Date: 09/18/2012 Location(s): CX: none Offices(s): Electricity Delivery and Energy Reliability June 12, 2012 CX-008821: Categorical Exclusion Determination NRG Power Marketing, LLC Docket EA-384

416

Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 |  

Broader source: Energy.gov (indexed) [DOE]

Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 As part of the Obama Administration's goals to enhance the security and reliability of the Nation's energy infrastructure, the U.S. Department of Energy released the 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity. Developed as an update to the 2006 Roadmap to Secure Control Systems in the Energy Sector, the report outlines a strategic framework over the next decade among industry, vendors, academia and government stakeholders to design, install, operate, and maintain a resilient energy delivery system capable of surviving a cyber incident while sustaining critical functions. Developed by the Energy Sector Control Systems Working Group, a partnership

417

Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

Subtopic c. References: Subtopic c. References: 1. Thomas B. Johansson, Henry Kelly, Amulya K.N. Reddy, and Robert H. Williams, "Renewable Energy: Sources for Fuels and Electricity", Island Press, 1993 2. Patrick Takahashi and Andrew Trenka, "Ocean Thermal Energy Conversion", John Wiley & sons, 1996. *All references can be accessed at: http://archive.epri.com/oceanenergy/streamenergy.html#reports OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY 28. NATURAL DISASTER REDUCTION THROUGH TECHNOLOGY The U.S. electric power sector is a critical part of our society. Virtually all aspects of residential, industrial, and commercial activities depend on safe, reliable, and affordable electricity. Electricity is among the most infrastructure-intensive segments of the energy sector - the electricity grid includes a network of 5,000 power

418

Abstract 4479: Influence of the blood-brain barrier on drug distribution and efficacy of PI3K/mTOR inhibitors  

Science Journals Connector (OSTI)

...Abstract 4479: Influence of the blood-brain barrier on drug distribution and efficacy...is influenced by the presence of blood-brain barrier (BBB). PI3K/mTOR/AKT is...with the former molecule optimized for brain delivery. Here the influence of the BBB...

Rajneet K. Oberoi; William F. Elmquist; Rajendar Mittapalli; Jenny Pokorny; Jann Sarkaria

2014-10-01T23:59:59.000Z

419

DOE Hydrogen and Fuel Cells Program: 2008 Annual Progress Report - Delivery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Delivery Delivery Printable Version 2008 Annual Progress Report III. Delivery This section of the 2008 Progress Report for the DOE Hydrogen Program focuses on delivery. Each technical report is available as an individual Adobe Acrobat PDF. Download Adobe Reader. Hydrogen Delivery Sub-Program Overview, Rick Farmer, U.S. Department of Energy (PDF 218 KB) Hydrogen Delivery Infrastructure Options Analysis, TP Chen, Nexant, Inc. (PDF 242 KB) Hydrogen Delivery Infrastructure Analysis, Marrianne Mintz, Argonne National Laboratory (PDF 324 KB) Hydrogen Embrittlement of Pipelines: Fundamentals, Experiments, Modeling, Petros Sofronis, University of Illinois, Urbana-Champaign (PDF 686 KB) Materials Solutions for Hydrogen Delivery in Steel Pipeline, Subodh Das, Secat, Inc. (PDF 691 KB)

420

Recreation service delivery by local governments in the North West Province] / Victor Solomon Mogajane.  

E-Print Network [OSTI]

??Service delivery in all aspects of life is a major problem facing the local, provincial and national governments in South Africa. Service delivery, in particular… (more)

Mogajane, Victor Solomon

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

2H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...  

Broader source: Energy.gov (indexed) [DOE]

pipelines for gaseous hydrogen delivery Option 2: Use of existing natural gas or oil pipelines for gaseous hydrogen delivery Option 3: Use of existing natural gas pipelines...

422

E-Print Network 3.0 - adenoviral gene delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for both inter and intra species gene therapy delivery in adults. The gene therapy vehicle is tolerated... cell potential Nonviral delivery of selected ... Source:...

423

E-Print Network 3.0 - advocates expanded delivery Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

POLICY AND MANAGEMENT JULY 14, 2010 Summary: DELIVERY SYSTEM REDESIGN The US health care delivery system is expensive, fragmented, highly decentralized... , efficient, and...

424

2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1 www.advmat.de  

E-Print Network [OSTI]

used as theranostic nanomedicine platforms for targeted drug delivery and high-throughput imaging.[8 theranostic nanobiomaterials. Polymeric nanoparticles are usually conjugated with additional organic dyes

Yang, Jian

425

Cancer theranostics: the rise of targeted magnetic nanoparticles  

Science Journals Connector (OSTI)

Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has increased considerably over the past two decades. This excitement has been driven in large part by the success of \\{MNPs\\} as contrast agents in magnetic resonance imaging. The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy, giving rise to the distinction of \\{MNPs\\} as potential “theranostics”. Here we review both the key technical principles of \\{MNPs\\} and ongoing advancement toward a cancer theranostic MNP. Recent progress in diagnostics, hyperthermia treatments, and drug delivery are all considered. We conclude by identifying current barriers to clinical translation of \\{MNPs\\} and offer considerations for their future development.

Adam J. Cole; Victor C. Yang; Allan E. David

2011-01-01T23:59:59.000Z

426

Clinton plan to speed cancer drug approval  

Science Journals Connector (OSTI)

Clinton plan to speed cancer drug approval ... Accelerated approval and three other proposals "will affect at least 100 drugs now being studied," he notes, cutting FDA review time for some of these drugs from 12 months to six months. ...

1996-04-08T23:59:59.000Z

427

Report on AOAC, Narcotic and Dangerous Drugs  

Science Journals Connector (OSTI)

......Report on AOAC, narcotic and dangerous drugs. | Journal Article...Report on AOAC, Narcotic and Dangerous Drugs by Anthony Romano...Bureau of Narcotics and Dangerous Drugs, Miami, Florida 33132...substances affect- ing public health." The AOAC itself maintains......

Anthony Romano; Jr.

1972-05-01T23:59:59.000Z

428

Clinical Manifestations of Allergic Diseases: Drug Hypersensitivity  

Science Journals Connector (OSTI)

Drug allergies are those adverse drug reactions that are mediated by the specific immune system. Primary sensitization may involve T-cells alone or both T and B-cells with consecutive production of drug specif...

Benno Schnyder; Werner J. Pichler

2009-01-01T23:59:59.000Z

429

Bounding Radionuclide Inventory and Accident Consequence Calculation for the 1L Target  

SciTech Connect (OSTI)

A bounding radionuclide inventory for the tungsten of the Los Alamos Neutron Science Center (LANSCE) IL Target is calculated. Based on the bounding inventory, the dose resulting from the maximum credible incident (MCI) is calculated for the maximally exposed offsite individual (MEOl). The design basis accident involves tungsten target oxidation following a loss of cooling accident. Also calculated for the bounding radionuclide inventory is the ratio to the LANSCE inventory threshold for purposes of inventory control as described in the target inventory control policy. A bounding radionuclide inventory calculation for the lL Target was completed using the MCNPX and CINDER'90 codes. Continuous beam delivery at 200 {micro}A to 2500 mA{center_dot}h was assumed. The total calculated activity following this irradiation period is 205,000 Ci. The dose to the MEOI from the MCI is 213 mrem for the bounding inventory. The LANSCE inventory control threshold ratio is 132.

Kelsey, Charles T. IV [Los Alamos National Laboratory

2011-01-01T23:59:59.000Z

430

The OLYMPUS Internal Hydrogen Target  

E-Print Network [OSTI]

An internal hydrogen target system was developed for the OLYMPUS experiment at DESY, in Hamburg, Germany. The target consisted of a long, thin-walled, tubular cell within an aluminum scattering chamber. Hydrogen entered at the center of the cell and exited through the ends, where it was removed from the beamline by a multistage pumping system. A cryogenic coldhead cooled the target cell to counteract heating from the beam and increase the density of hydrogen in the target. A fixed collimator protected the cell from synchrotron radiation and the beam halo. A series of wakefield suppressors reduced heating from beam wakefields. The target system was installed within the DORIS storage ring and was successfully operated during the course of the OLYMPUS experiment in 2012. Information on the design, fabrication, and performance of the target system is reported.

Bernauer, J C; Ciullo, G; Henderson, B S; Ihloff, E; Kelsey, J; Lenisa, P; Milner, R; Schmidt, A; Statera, M

2014-01-01T23:59:59.000Z

431

The OLYMPUS Internal Hydrogen Target  

E-Print Network [OSTI]

An internal hydrogen target system was developed for the OLYMPUS experiment at DESY, in Hamburg, Germany. The target consisted of a long, thin-walled, tubular cell within an aluminum scattering chamber. Hydrogen entered at the center of the cell and exited through the ends, where it was removed from the beamline by a multistage pumping system. A cryogenic coldhead cooled the target cell to counteract heating from the beam and increase the density of hydrogen in the target. A fixed collimator protected the cell from synchrotron radiation and the beam halo. A series of wakefield suppressors reduced heating from beam wakefields. The target system was installed within the DORIS storage ring and was successfully operated during the course of the OLYMPUS experiment in 2012. Information on the design, fabrication, and performance of the target system is reported.

J. C. Bernauer; V. Carassiti; G. Ciullo; B. S. Henderson; E. Ihloff; J. Kelsey; P. Lenisa; R. Milner; A. Schmidt; M. Statera

2014-04-02T23:59:59.000Z

432

Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Indiana (Electric) - Commercial New Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction Rebates (Indiana) Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction Rebates (Indiana) < Back Eligibility Commercial Fed. Government Industrial Local Government Nonprofit State Government Savings Category Home Weatherization Commercial Weatherization Heating & Cooling Commercial Heating & Cooling Cooling Other Heat Pumps Appliances & Electronics Commercial Lighting Lighting Windows, Doors, & Skylights Maximum Rebate Custom/HVAC Systems: $100,000 or 50% of the total project cost Incentive cannot buy down project below 1.5 years payback. Program Info State Indiana Program Type Utility Rebate Program Rebate Amount HVAC Systems (New Construction): $0.12/kWh reduced

433

THUMBS DOWN ON DRUG WAR WEAPON  

Science Journals Connector (OSTI)

THUMBS DOWN ON DRUG WAR WEAPON ... Mycoherbicides have been viewed as a potentially potent weapon in the worldwide war on illicit drugs. ...

CHERYL HOGUE

2011-12-05T23:59:59.000Z

434

Plan to speed up drug review approved  

Science Journals Connector (OSTI)

Plan to speed up drug review approved ... Proposed changes in the New Drug Application procedure will shorten review times, reduce paperwork, and save money ...

DAVID HANSON

1982-07-12T23:59:59.000Z

435

Photosensitizer Conjugates For Pathogen Targeting  

DOE Patents [OSTI]

Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.

Hasan, Tayyaba (Arlington, MA); Hamblin, Michael R. (Revere, MA); Soukos, Nikos (Revere, MA)

2002-10-08T23:59:59.000Z

436

POLARIZED TARGET EXPERIMENT AT FERMILAB  

E-Print Network [OSTI]

on Experiment 61 at Fermilab, which is a large collaborationBernie Sandler, From From Fermilab. Alan Jonckheere andTARGET EXPERIMENT AT FERMILAB Owen Chamberlain January 1977

Chamberlain, O.

2010-01-01T23:59:59.000Z

437

Non-PGM Target Update  

Broader source: Energy.gov (indexed) [DOE]

etc. * Volumetric activity no longer part of the metrics * No iR correction * No Tafel extrapolation to the reference potential (voltage) * Fuel cell performance targets on...

438

Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu  

E-Print Network [OSTI]

Targeted delivery of drugs and sensors into cells is an attractive technology with both medical and scientific applications. Existing delivery vehicles are generally limited by the complexity of their design, dependence ...

Vemula, Praveen Kumar

439

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs.

440

The Office of Electricity Delivery and Energy Reliability is Closely  

Broader source: Energy.gov (indexed) [DOE]

The Office of Electricity Delivery and Energy Reliability is The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) August 25, 2011 - 11:13am Addthis The Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is closely monitoring Hurricane Irene as it travels up the U.S. coast and is publishing Situation Reports. Addthis Related Articles Sandy made landfall as a post-tropical cyclone on the southern coast of New Jersey near Atlantic City at 8 p.m. on October 29, with top sustained winds of 80 mph. | Photo courtesy of NOAA. Responding To Hurricane Sandy: DOE Situation Reports On November 7, a Nor'easter began to impact the Mid-Atlantic and Northeast with strong winds, rain or snow, and coastal flooding. | Photo courtesy of NOAA.

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Secretary Chu's Remarks as Prepared for Delivery at the Washington  

Broader source: Energy.gov (indexed) [DOE]

as Prepared for Delivery at the Washington as Prepared for Delivery at the Washington University Commencement Secretary Chu's Remarks as Prepared for Delivery at the Washington University Commencement May 21, 2010 - 12:00am Addthis Remarks of Secretary Steven Chu- As Prepared for Delivery Washington University Friday, May 21, 2010 Chancellor Mark Wrighton, the Board of Trustees, faculty, family, and friends here today, thank you for letting me share this wonderful day with you. It is a special privilege to return to the campus where my father began his career as a professor of chemical engineering. To the new graduates: Congratulations on your achievements. This year is the 40th anniversary of my own commencement. I know from personal experience that you will probably not remember what I will have said five years from today. I could stand here and read the phone book -

442

Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to Hydrogen to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad Elgowainy Argonne National Laboratory Comparison of Delivery Pathways- V1.0 vs. V2.0 2 1 3 i delivery by a Loading, the plant Version 1.0 character zed components for 3 pathways with single mode. conditioning and storage are at or adjacent to Liquid Hydrogen (LH) Truck H2 Production 100 or 1500 kg/d Compressed H2 (CH) Truck H2 Production 3 or 7 kpsi 100 or 1500 kg/d H2 Production Gaseous H2 Pipeline 100 or 1500 kg/d HDSAM V1.0 Estimates Delivery Cost for 3 Pathways 4 H2 H2 1 2 3 H2 Distribution and Ci I. Liquid H2 Distribution: HDSAM V2.0 Simulates Nine Pathways Production Production LH Terminal LH Terminal Production LH Terminal Transmission Transmission Distribution

443

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Secure Communications Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Secure Communications are below. CEDS 2010 Peer Review - Cryptographic Trust Management - Mark Hadley,

444

EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts |  

Broader source: Energy.gov (indexed) [DOE]

EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts The Office of Environmental Management (EM) has 23 Indefinite Delivery/Indefinite Quantity (IDIQ) contracts to provide cleanup services at EM sites across the United States. The scope of work of the IDIQ contracts includes: environmental remediation deactivation, decommissioning, demolition and removal of contaminated facilities waste management regulatory compliance These nationwide, multiple-award IDIQ contracts allow EM sites to place timely, competitive and cost-effective task orders for environmental services with either large or small businesses, as determined by the complexity of the requirements. Twelve of the IDIQ contracts were awarded

445

Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

delivery of compressed hydrogen delivery of compressed hydrogen with advanced vessel technology Gene Berry Andrew Weisberg Salvador M. Aceves Lawrence Livermore National Laboratory (925) 422-0864 saceves@LLNL.GOV DOE and FreedomCar & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop Washington, DC January 25, 2006 LLNL is developing innovative concepts for efficient containment of hydrogen in light duty vehicles concepts may offer advantages for hydrogen delivery Conformable containers efficiently use available space in the vehicle. We are pursuing multiple approaches to conformability High Strength insulated pressure vessels extend LH 2 dormancy 10x, eliminate boiloff, and enable efficiencies of flexible refueling (compressed/cryogenic H 2 /(L)H 2 ) The PVT properties of H

446

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Vulnerability and Intrusion Detection Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Vulnerability and Instrusion Detection are below.

447

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Vulnerability and Intrusion Detection Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Vulnerability and Instrusion Detection are below.

448

Oncor Electric Delivery Company LLC | Open Energy Information  

Open Energy Info (EERE)

Oncor Electric Delivery Company LLC Oncor Electric Delivery Company LLC (Redirected from Oncor Electric Delivery Company, LLC) Jump to: navigation, search Name Oncor Electric Delivery Company LLC Place Texas Service Territory Texas Website www.oncor.com/EN/Pages/de Green Button Landing Page www.smartmetertexas.com/C Green Button Reference Page www.emeter.com/smart-grid Green Button Implemented Yes Utility Id 44372 Utility Location Yes Ownership I NERC Location TRE NERC ERCOT Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Buying Distribution Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it.

449

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Best Practices/Standards Development Best Practices/Standards Development Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practices/Standards Development National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Best Practices/Standards Development are below.

450

Optimal Placement of Wind Power Plants for Delivery Loss Minimization  

Science Journals Connector (OSTI)

In this chapter we investigate how to minimize power delivery losses in the distribution system on ... We show that strategically placing and utilizing new wind power plants can lead to significant loss reduction...

Masoud Honarvar Nazari

2013-01-01T23:59:59.000Z

451

United Parcel Service Evaluates Hybrid Electric Delivery Vans...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans-fueled by regular diesel-and six comparable conventional diesel...

452

FedEx Express Gasoline Hybrid Electric Delivery Truck Evaluation...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

vehicles currently in service. FedEx Express has deployed 20 gasoline hybrid electric vehicles (gHEVs) on parcel delivery routes in the Sacramento and Los Angeles areas. This...

453

Agenda for the Hydrogen Delivery and Onboard Storage Analysis...  

Broader source: Energy.gov (indexed) [DOE]

- T. P. Chen, Nexant 2:45 pm Break 3:00 pm Hydrogen Delivery Demonstrations - Ed Kiczek, Air Products & Chemicals, Inc. 3:10 pm Pathway Cost Distributions: Fuel Pathway...

454

Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...  

Broader source: Energy.gov (indexed) [DOE]

8:15 H2A Delivery Model Changes and Discussion: Matt Hooks (TIAX LLC), Bruce Kelly (Nexant), Jerry Gillette (ANL), Matt Ringer (NREL), Amgad Elgowainy (ANL) 8:15...

455

,"New York Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

,,"(202) 586-8800",,,"182015 12:47:52 PM" "Back to Contents","Data 1: New York Natural Gas Deliveries to Electric Power Consumers (MMcf)" "Sourcekey","N3045NY2"...

456

Vacancy Announcements Posted for Hydrogen Production and Delivery Program  

Broader source: Energy.gov [DOE]

The Fuel Cell Technologies Office has posted two vacancy announcements for a position to serve as Program Manager for the Hydrogen Production and Delivery Program in the DOE EERE Fuel Cell Technologies Office. The closing date is October 28, 2014.

457

A simulation study for a coal delivery system  

Science Journals Connector (OSTI)

This paper discusses a computer simulation model that was constructed to assist in evaluating alternatives for a coal delivery system. A complex system, involving unit trains, intermediate storage, transshipment and lake vessels is required to transport ...

T. C. Vorce

1982-03-01T23:59:59.000Z

458

A vector-free microfluidic platform for intracellular delivery  

E-Print Network [OSTI]

Intracellular delivery of macromolecules is a challenge in research and therapeutic applications. Existing vector-based and physical methods have limitations, including their reliance on exogenous materials or electrical ...

Sharei, Armon Reza

459

Office of Electricity Delivery and Energy Reliability, OE-20  

Broader source: Energy.gov (indexed) [DOE]

6, 2012 Office of Electricity Delivery and Energy Reliability, OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 RE: Comments for Consideration in...

460

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Energy Savers [EERE]

March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C....

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Mr. Lamont Jackson Office of Electricity Delivery and Energy...  

Energy Savers [EERE]

March 28, 2012 Mr. Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585...

462

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Energy Savers [EERE]

March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585...

463

Office of Electricity Delivery And Energy Reliability To Hold Technical  

Broader source: Energy.gov (indexed) [DOE]

Office of Electricity Delivery And Energy Reliability To Hold Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission February 5, 2009 - 10:57am Addthis On March 4, 2009, the Department of Energy's Office of Electricity Delivery and Energy Reliability (OE) will conduct a technical conference in the Washington, DC area to discuss the design of future electric transmission. The technical conference will discuss the likely demand for future electric transmission and whether the development of conceptual alternative extra high voltage (EHV) systems would assist generation developers, State energy policy officials, utility planners, and other

464

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Broader source: Energy.gov (indexed) [DOE]

Practice Design/Configuration Practice Design/Configuration Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practice Design/Configuration National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Best Practice Design/Configuration are below.

465

Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM...  

Broader source: Energy.gov (indexed) [DOE]

Gaseous Forecourt kg Sum kg kg Energy Fue Other O&M Cap ta Indianapolis, Compressed Gas (5000 psi Delivery, 20% M arket Penetration, 850 kg day Station, 62 miles to City...

466

Home use of closed loop insulin delivery improves overnight glucose control in adults with type 1 diabetes: A four-week multicentre randomised crossover study  

E-Print Network [OSTI]

system 21 comprised a model predictive control (MPC) algorithm residing on a handheld computer linked by cable to the continuous glucose monitoring receiver. Every 12 minutes, the treat-to-target algorithm calculated a new insulin infusion rate, which... that limited maximum insulin infusion and suspended insulin delivery if glucose was at or below 4·3mmol/l or when glucose was rapidly decreasing. Algorithm version 0·3·24 was used (University of Cambridge). Assays 6 We used a chemiluminescence...

Thabit, Hood; Lubina-Solomon, Alexandra; Stadler, Marietta; Leelarathna, Lalantha; Walkinshaw, Emma; Pernet, Andrew; Allen, Janet M.; Iqbal, Ahmed; Choudhary, Pratik; Kumareswaran, Kavita; Nodale, Marianna; Nisbet, Chloe; Wilinska, Malgorzata E.; Barnard, Katherine D.; Dunger, David B.; Heller, Simon R.; Amiel, Stephanie A.; Evans, Mark L.; Hovorka, Roman

2014-06-16T23:59:59.000Z

467

Delivery system for molten salt oxidation of solid waste  

DOE Patents [OSTI]

The present invention is a delivery system for safety injecting solid waste particles, including mixed wastes, into a molten salt bath for destruction by the process of molten salt oxidation. The delivery system includes a feeder system and an injector that allow the solid waste stream to be accurately metered, evenly dispersed in the oxidant gas, and maintained at a temperature below incineration temperature while entering the molten salt reactor.

Brummond, William A. (Livermore, CA); Squire, Dwight V. (Livermore, CA); Robinson, Jeffrey A. (Manteca, CA); House, Palmer A. (Walnut Creek, CA)

2002-01-01T23:59:59.000Z

468

Percentage of Total Natural Gas Commercial Deliveries included in Prices  

Gasoline and Diesel Fuel Update (EIA)

City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area May-13 Jun-13 Jul-13 Aug-13 Sep-13 Oct-13 View History U.S. 63.3 59.3 57.9 57.0 57.4 61.3 1983-2013 Alabama 71.7 71.0 68.5 68.2 68.4 66.7 1989-2013 Alaska 94.1 91.6 91.1 91.0 92.3 92.6 1989-2013 Arizona 84.0 83.0 81.6 80.3 82.8 82.7 1989-2013 Arkansas 37.8 28.3 28.1 28.6 26.7 28.0 1989-2013

469

Percentage of Total Natural Gas Industrial Deliveries included in Prices  

Gasoline and Diesel Fuel Update (EIA)

City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area May-13 Jun-13 Jul-13 Aug-13 Sep-13 Oct-13 View History U.S. 16.5 16.3 16.0 16.2 16.6 16.9 2001-2013 Alabama 22.1 21.7 21.6 22.8 22.0 22.7 2001-2013 Alaska 100.0 100.0 100.0 100.0 100.0 100.0 2001-2013 Arizona 13.4 15.7 15.3 13.8 13.7 13.9 2001-2013 Arkansas 1.7 1.4 1.2 1.4 1.3 1.5 2001-2013

470

Economic and Conservation Evaluation of Capital Renovation Projects: Harlingen Irrigation District Cameron County No. 1 Canal Meters and Telemetry Equipment, Impervious-Lining of Delivery Canals, Pipelines Replacing Delivery Canals, and On-Farm Delivery-Site Meters  

E-Print Network [OSTI]

, impervious-lining of delivery canals, 24" pipelines replacing delivery canals, and on-farm delivery-site meters). Sensitivity results for both the cost of water savings and cost of energy savings are presented for several important parameters. Expected cost...

Rister, M. Edward; Lacewell, Ronald D.; Sturdivant, Allen W.; Robinson, John R.C.; Popp, Michael C.; Ellis, John R.

471

The overdose of drugs in Japan  

Science Journals Connector (OSTI)

... spenders on prescription drugs. Among the top-selling drugs are anti-cancer agents peculiar to Japan that are of questionable efficacy and yet have sales of hundreds of millions of dollars ... -cancer drugs in other developed nations. Moreover, several of the drugs sold only in Japan have serious side effects. Justification of these contentions is to be found in Tables ...

Masanori Fukushima

1989-12-28T23:59:59.000Z

472

Polypharmacology Modelling Using Proteochemometrics (PCM): Recent Methodological Developments, Applications to Target Families, and Future Prospects  

E-Print Network [OSTI]

to be in the order of $1.8 billion per drug. In addition, price pressure from health care providers has been increasing and there is a growing relevance of more targeted medicine. Hence, the ‘blockbuster model’ of the pharmaceutical industry is being challenged.1...

Cortés-Ciriano, Isidro; ul Ain, Qurrat; Subramanian, Vigneshwari; Lenselink, Eelke B.; Méndez-Lucio, Oscar; IJzerman, Adriaan P.; Wohlfahrt, Gerd; Prusis, Peteris; Malliavin, Thérèse E.; van Westen, Gerard J. P.; Bender, Andreas

2014-10-07T23:59:59.000Z

473

A method of dose reconstruction for moving targets compatible with dynamic treatments  

SciTech Connect (OSTI)

Purpose: To develop a method that allows a commercial treatment planning system (TPS) to perform accurate dose reconstruction for rigidly moving targets and to validate the method in phantom measurements for a range of treatments including intensity modulated radiation therapy (IMRT), volumetric arc therapy (VMAT), and dynamic multileaf collimator (DMLC) tracking. Methods: An in-house computer program was developed to manipulate Dicom treatment plans exported from a TPS (Eclipse, Varian Medical Systems) such that target motion during treatment delivery was incorporated into the plans. For each treatment, a motion including plan was generated by dividing the intratreatment target motion into 1 mm position bins and construct sub-beams that represented the parts of the treatment that were delivered, while the target was located within each position bin. For each sub-beam, the target shift was modeled by a corresponding isocenter shift. The motion incorporating Dicom plans were reimported into the TPS, where dose calculation resulted in motion including target dose distributions. For experimental validation of the dose reconstruction a thorax phantom with a moveable lung equivalent rod with a tumor insert of solid water was first CT scanned. The tumor insert was delineated as a gross tumor volume (GTV), and a planning target volume (PTV) was formed by adding margins. A conformal plan, two IMRT plans (step-and-shoot and sliding windows), and a VMAT plan were generated giving minimum target doses of 95% (GTV) and 67% (PTV) of the prescription dose (3 Gy). Two conformal fields with MLC leaves perpendicular and parallel to the tumor motion, respectively, were generated for DMLC tracking. All treatment plans were delivered to the thorax phantom without tumor motion and with a sinusoidal tumor motion. The two conformal fields were delivered with and without portal image guided DMLC tracking based on an embedded gold marker. The target dose distribution was measured with a radiochromic film in the moving rod and compared with the reconstructed doses using gamma tests. Results: Considerable interplay effects between machine motion and target motion were observed for the treatments without tracking. For nontracking experiments, the mean 2 mm/2% gamma pass rate over all investigated scenarios was 99.6% between calculated and measured doses. For tracking experiments, the mean gamma pass rate was 99.4%. Conclusions: A method for accurate dose reconstruction for moving targets with dynamic treatments was developed and experimentally validated in a variety of delivery scenarios. The method is suitable for integration into TPSs, e.g., for reconstruction of the dose delivered to moving tumors or calculation of target doses delivered with DMLC tracking.

Rugaard Poulsen, Per; Lykkegaard Schmidt, Mai; Keall, Paul; Schjodt Worm, Esben; Fledelius, Walther; Hoffmann, Lone [Department of Oncology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Institute of Clinical Medicine, Aarhus University, Brendstrupgaardsvej 100, 8200 Aarhus N (Denmark); Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C (Denmark); Radiation Physics Laboratory, Sydney Medical School, University of Sydney, NSW 2006 (Australia); Department of Oncology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Department of Medical Physics, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark); Department of Oncology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark); Department of Medical Physics, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark)

2012-10-15T23:59:59.000Z

474

Computer modeling reveals how surprisingly potent hepatitis C drug works  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hepatitis C computer modeling Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

475

Id-1 and Id-2 genes and products as therapeutic targets for treatment of breast cancer and other types of carcinoma  

DOE Patents [OSTI]

A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.

Desprez, Pierre-Yves; Campisi, Judith

2014-09-30T23:59:59.000Z

476

Strategic Directions for Hydrogen Delivery Workshop Proceedings  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

W W W o o r r k k s s h h o o p p P P r r o o c c e e e e d d i i n n g g s s M M a a y y 7 7 - - 8 8 , , 2 2 0 0 0 0 3 3 C C r r y y s s t t a a l l C C i i t t y y M M a a r r r r i i o o t t t t A A r r l l i i n n g g t t o o n n , , V V A A S S p p o o n n s s o o r r e e d d b b y y U U . . S S . . D D e e p p a a r r t t m m e e n n t t o o f f E E n n e e r r g g y y O O f f f f i i c c e e o o f f E E n n e e r r g g y y E E f f f f i i c c i i e e n n c c y y a a n n d d R R e e n n e e w w a a b b l l e e E E n n e e r r g g y y O O f f f f i i c c e e o o f f H H y y d d r r o o g g e e n n , , F F u u e e l l C C e e l l l l s s , , a a n n d d I I n n f f r r a a s s t t r r u u c c t t u u r r e e T T e e c c h h n n o o l l o o g g i i e e s s P P r r o o g g r r a a m m Strategic Directions for Hydrogen Delivery Workshop i May 2003 Table of Contents INTRODUCTION ...........................................................................................................................................................................................1 BACKGROUND.............................................................................................................................................................................................1

477

Countdown to Fixed Target INSIDE  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

17, 1996 17, 1996 Number 10 Countdown to Fixed Target INSIDE 2 University Close-Up: The University of Illinois 4 Tollestrup Elected to National Academy 5 Bardeen Receives Sakurai Prize 6 Take Your Daughters and Sons to Work Day "At this moment," Fermilab Director John Peoples told the House Subcommittee on Energy and Environment in testimony deliv- ered in Washington on May 8, "Fermilab is in the midst of the transition from collider opera- tions to fixed-target operations. In June, we will begin extracting a beam of protons from the Tevatron, the highest-energy external beam in the world. By directing this beam onto eight targets we will create eight distinct particle beams that will in turn support 10 unique experiments. Although fixed-target experi- ments cannot explore the high-energy frontier

478

IPNS enriched uranium booster target  

SciTech Connect (OSTI)

Since startup in 1981, IPNS has operated on a fully depleted /sup 238/U target. With the booster as in the present system, high energy protons accelerated to 450 MeV by the Rapid Cycling Synchrotron are directed at the target and by mechanisms of spallation and fission of the uranium, produce fast neutrons. The neutrons from the target pass into adjacent moderator where they slow down to energies useful for spectroscopy. The target cooling systems and monitoring systems have operated very reliably and safely during this period. To provide higher neutron intensity, we have developed plans for an enriched uranium (booster) target. HETC-VIM calculations indicate that the target will produce approx.90 kW of heat, with a nominal x5 gain (k/sub eff/ = 0.80). The neutron beam intensity gain will be a factor of approx.3. Thermal-hydraulic and heat transport calculations indicate that approx.1/2 in. thick /sup 235/U discs are subject to about the same temperatures as the present /sup 238/U 1 in. thick discs. The coolant will be light demineralized water (H/sub 2/O) and the coolant flow rate must be doubled. The broadening of the fast neutron pulse width should not seriously affect the neutron scattering experiments. Delayed neutrons will appear at a level about 3% of the total (currently approx.0.5%). This may affect backgrounds in some experiments, so that we are assessing measures to control and correct for this (e.g., beam tube choppers). Safety analyses and neutronic calculations are nearing completion. Construction of the /sup 235/U discs at the ORNL Y-12 facility is scheduled to begin late 1985. The completion of the booster target and operation are scheduled for late 1986. No enriched uranium target assembly operating at the projected power level now exists in the world. This effort thus represents an important technological experiment as well as being a ''flux enhancer''.

Schulke, A.W. Jr.

1985-01-01T23:59:59.000Z

479

A Fluorescence Displacement Assay for Antidepressant Drug Discovery Based on Ligand-Conjugated Quantum Dots  

SciTech Connect (OSTI)

The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) protein plays a central role in terminating 5-HT neurotransmission and is the most important therapeutic target for the treatment of major depression and anxiety disorders. We report an innovative, versatile, and target-selective quantum dot (QD) labeling approach for SERT in single Xenopus oocytes that can be adopted as a drug-screening platform. Our labeling approach employs a custom-made, QD-tagged indoleamine derivative ligand, IDT318, that is structurally similar to 5-HT and accesses the primary binding site with enhanced human SERT selectivity. Incubating QD-labeled oocytes with paroxetine (Paxil), a high-affinity SERT-specific inhibitor, showed a concentration- and time-dependent decrease in QD fluorescence, demonstrating the utility of our approach for the identification of SERT modulators. Furthermore, with the development of ligands aimed at other pharmacologically relevant targets, our approach may potentially form the basis for a multitarget drug discovery platform.

Chang, Jerry [Vanderbilt University; Tomlinson, Ian [Oak Ridge National Laboratory (ORNL); Warnement, Michael [Vanderbilt University; Iwamoto, Hideki [Vanderbilt University

2011-01-01T23:59:59.000Z

480

ChemCam laser sets its sights on first martian target  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

First martian target First martian target ChemCam laser sets its sights on first martian target The successful capture of ChemCam's first 10 photos sets the stage for the first test bursts of the instrument's rock-zapping laser in the near future. August 17, 2012 Curiosity zaps Mars for vital signs: ChemCam, designed by Lab team, looks for elements such as carbon, nitrogen, and oxygen, all of which are crucial for life. Curiosity zaps Mars for vital signs: ChemCam, designed by Lab team, looks for elements such as carbon, nitrogen, and oxygen, all of which are crucial for life. Contact James E. Rickman Communications Office (505) 665-9203 Email "The successful delivery of these photos means we can begin efforts in earnest for the first images of Mars rocks by the ChemCam instrument and

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481

Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan  

Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

Natural Gas Delivery Natural Gas Delivery Vans Support McShan Florist to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Twitter Bookmark Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Google Bookmark Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Delicious Rank Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Digg Find More places to share Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on AddThis.com... May 25, 2012 Natural Gas Delivery Vans Support McShan Florist W atch how a Dallas, Texas, florist reduces emissions and saves money

482

Pseudomonas aeruginosa biofilm: Potential therapeutic targets  

Science Journals Connector (OSTI)

Abstract Pseudomonas aeruginosa is a gram-negative pathogen that has become an important cause of infection, especially in patients with compromised host defense mechanisms. It is frequently related to nosocomial infections such as pneumonia, urinary tract infections (UTIs) and bacteremia. The biofilm formed by the bacteria allows it to adhere to any surface, living or non-living and thus Pseudomonal infections can involve any part of the body. Further, the adaptive and genetic changes of the micro-organisms within the biofilm make them resistant to all known antimicrobial agents making the Pseudomonal infections complicated and life threatening. Pel, Psl and Alg operons present in P. aeruginosa are responsible for the biosynthesis of extracellular polysaccharide which plays an important role in cell–cell and cell–surface interactions during biofilm formation. Understanding the bacterial virulence which depends on a large number of cell-associated and extracellular factors is essential to know the potential drug targets for future studies. Current novel methods like small molecule based inhibitors, phytochemicals, bacteriophage therapy, photodynamic therapy, antimicrobial peptides, monoclonal antibodies and nanoparticles to curtail the biofilm formed by P. aeruginosa are being discussed in this review.

Garima Sharma; Saloni Rao; Ankiti Bansal; Shweta Dang; Sanjay Gupta; Reema Gabrani

2014-01-01T23:59:59.000Z

483

Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of  

Broader source: Energy.gov (indexed) [DOE]

SPR Oil to Marathon Petroleum Company SPR Oil to Marathon Petroleum Company Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of SPR Oil to Marathon Petroleum Company September 8, 2008 - 3:20pm Addthis WASHINGTON, DC - Today, September 8, 2008, the U.S. Department of Energy will deliver 250,000 barrels of oil from the Strategic Petroleum Reserve to Marathon Petroleum Company's Midwest refineries along the Capline pipeline system. The oil was requested by Marathon because of disruptions in supply caused by Hurricane Gustav. Media contact(s): Healy Baumgardner, (202) 586-4940 Addthis Related Articles Statement from DOE's Chief Spokesperson Andrew Beck Regarding Strategic Petroleum Reserve Oil Deliveries Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of

484

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

November 4, 2010 November 4, 2010 CX-004397: Categorical Exclusion Determination The Padlock Project CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 11/04/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory October 27, 2010 CX-004331: Categorical Exclusion Determination Long Island Smart Energy Corridor CX(s) Applied: A1, A9, A11 Date: 10/27/2010 Location(s): Stony Brook, New York Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory October 27, 2010 CX-004330: Categorical Exclusion Determination Long Island Smart Energy Corridor CX(s) Applied: A9, A11, B3.6, B4.4, B5.1 Date: 10/27/2010 Location(s): Farmingdale, New York Office(s): Electricity Delivery and Energy Reliability, National Energy

485

Design-Build Project Delivery | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Design-Build Project Delivery Design-Build Project Delivery Design-Build Project Delivery October 16, 2013 - 4:46pm Addthis Renewable energy must be integrated into each of the design phases. Noting that any agency may have specific processes during the development of a construction project, this section discusses key issues in the following phases of the design-build process: Planning and Programming Request for Qualifications Request for Proposal Construction Contract Design and Build Integrating renewable energy into design-bid-build strategy involves a few different approaches, which are covered in the main building design section of this guide. Planning and Programming The planning and programming phase should look the same regardless of whether the project is design-bid-build or design-build. An early team is

486

Vectren Energy Delivery of Ohio (Gas) - Commercial Energy Efficiency  

Broader source: Energy.gov (indexed) [DOE]

Ohio (Gas) - Commercial Energy Ohio (Gas) - Commercial Energy Efficiency Rebates Vectren Energy Delivery of Ohio (Gas) - Commercial Energy Efficiency Rebates < Back Eligibility Commercial Industrial Savings Category Heating & Cooling Commercial Heating & Cooling Heating Other Commercial Weatherization Maximum Rebate Boilers: $5,000 Boiler Tune-Up: $250 Custom Incentives: 30% of the total project cost or $25,000/project Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Boilers: 25% of cost Boiler Tune-Up: 50% of cost Furnace: $200 Programmable Thermostat: $20 Custom Incentives: $0.75/therm (less than 7500 therm savings) or $1/therm (greater than 7500 therm savings) calculated based on first year energy savings. Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery offers commercial natural gas customers in Ohio

487

Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency  

Broader source: Energy.gov (indexed) [DOE]

Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency Rebates Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency Rebates < Back Eligibility Commercial Fed. Government Local Government Nonprofit State Government Savings Category Heating & Cooling Commercial Heating & Cooling Heating Other Commercial Weatherization Appliances & Electronics Water Heating Maximum Rebate Boilers: $5,000 Boiler Modulating Burner Control: $5,000 Infrared Heater: $700 Custom: Contact Vectren Program Info State Indiana Program Type Utility Rebate Program Rebate Amount Boilers: $4/MMbtu Boiler Modulating Burner Control: up to $5000 Boiler Reset Control or Tune-Up: $250 Boiler Tune-up: $200 Furnace: $150 - $275 Tank Water Heater: $125 - $150 Tankless Water Heater: $150

488

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

February 9, 2010 February 9, 2010 CX-000760: Categorical Exclusion Determination Amber Kinetics Flywheel Energy Storage Demonstration CX(s) Applied: B3.6 Date: 02/09/2010 Location(s): Freemont, California Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 8, 2010 CX-000762: Categorical Exclusion Determination Eastern Interconnection Planning Collaborative CX(s) Applied: A9 Date: 02/08/2010 Location(s): Morristown, Pennsylvania Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 8, 2010 CX-000764: Categorical Exclusion Determination Dynamic Line Rating Project CX(s) Applied: B3.11, B4.6 Date: 02/08/2010 Location(s): Texas Office(s): Electricity Delivery and Energy Reliability, National Energy

489

Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery |  

Broader source: Energy.gov (indexed) [DOE]

Deputy Secretary Poneman's Remarks at TERI - As Prepared for Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery July 18, 2011 - 6:15pm Addthis U.S. Deputy Secretary of Energy Daniel Poneman Remarks As Prepared for Delivery at TERI Monday, July 18, 2011 New Delhi, India Good morning. Thank you, Mr. Desai for the introduction. And thank you to TERI for hosting me this afternoon. I want to acknowledge the leadership TERI is already showing in advancing energy research and in fostering a constructive dialogue on issues that are critical to the people of India and to the world. We are grateful for your commitment and dedication, and for the work that you do every day. Before I begin my remarks today, I want to take a moment on behalf of the

490

Oncor Electric Delivery - Government and Education Facilities Program |  

Broader source: Energy.gov (indexed) [DOE]

Oncor Electric Delivery - Government and Education Facilities Oncor Electric Delivery - Government and Education Facilities Program Oncor Electric Delivery - Government and Education Facilities Program < Back Eligibility Institutional Local Government Schools Tribal Government Savings Category Home Weatherization Commercial Weatherization Heating & Cooling Commercial Heating & Cooling Cooling Other Construction Heat Pumps Appliances & Electronics Commercial Lighting Lighting Manufacturing Insulation Design & Remodeling Windows, Doors, & Skylights Program Info State Texas Program Type Utility Rebate Program Rebate Amount Chillers (Metro): $225.72/kW plus $0.07/kWh Chillers (Non-Metro): $219.82/kW plus $0.08/kWh DX HVAC (Metro): $191.15/kW plus $0.06/kWh DX HVAC (Non-Metro): $219.82/kW plus $0.07/kWh Geothermal (Metro): $251.45/kW plus $0.08/kWh

491

Oncor Electric Delivery - Large Commercial and Industrial Rebate Program |  

Broader source: Energy.gov (indexed) [DOE]

Oncor Electric Delivery - Large Commercial and Industrial Rebate Oncor Electric Delivery - Large Commercial and Industrial Rebate Program Oncor Electric Delivery - Large Commercial and Industrial Rebate Program < Back Eligibility Commercial Construction Industrial Installer/Contractor Institutional Local Government Schools State Government Savings Category Heating & Cooling Commercial Heating & Cooling Cooling Manufacturing Other Heat Pumps Appliances & Electronics Commercial Lighting Lighting Home Weatherization Insulation Design & Remodeling Windows, Doors, & Skylights Solar Buying & Making Electricity Water Heating Wind Maximum Rebate General: 20% of the incentive budget in a given budget year Contact Oncor for additional details Program Info State Texas Program Type Utility Rebate Program Rebate Amount DX Air Conditioning: $285.30/kW; $0.09/kWh

492

Office of Electricity Delivery and Energy Reliability FY 2010 Budget |  

Broader source: Energy.gov (indexed) [DOE]

FY 2010 FY 2010 Budget Office of Electricity Delivery and Energy Reliability FY 2010 Budget The FY 2010 Office of Electricity Delivery and Energy Reliability (OE) budget request is $208.0 million, $71.0 million more than the FY 2009 Appropriation. This increase reflects increased investments in research and development, particularly in energy storage, smart grid technologies, and cyber security areas. OE will also establish one of the Department's multi-disciplinary Energy Innovation Hubs (Hubs) that specifically focuses on Grid Materials, Devices, and Systems. The FY 2010 budget proposes a budget structure change to better align with the Department's priorities to establish a clean, secure energy future. Office of Electricity Delivery and Energy Reliability FY 2010 Budget

493

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Broader source: Energy.gov (indexed) [DOE]

August 20, 2010 August 20, 2010 CX-003473: Categorical Exclusion Determination Pacific Northwest Smart Grid Demonstration CX(s) Applied: A1, A9, A11, B1.7, B4.4, B4.7, B4.11, B5.1 Date: 08/20/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory August 17, 2010 CX-003429: Categorical Exclusion Determination Oswego County BOCES Wind Turbine Model Project CX(s) Applied: A9, B1.15, B5.1 Date: 08/17/2010 Location(s): Mexico, New York Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory August 5, 2010 CX-003312: Categorical Exclusion Determination Power Grid Reliability and Security ? Phase II CX(s) Applied: A9, A11 Date: 08/05/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy

494

Competition Advocates and Task-Order and Delivery Order Ombudsman |  

National Nuclear Security Administration (NNSA)

Competition Advocates and Task-Order and Delivery Order Ombudsman | Competition Advocates and Task-Order and Delivery Order Ombudsman | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Competition Advocates and Task-Order and Delivery Order Ombudsman Home > About Us > Our Operations > Acquisition and Project Management > Office of Acquisition Management (OAM) > Competition Advocates and

495

Tank Farms and Waste Feed Delivery - 12507  

SciTech Connect (OSTI)

The mission of the Department of Energy's Office of River Protection (ORP) is to safely retrieve and treat the 56 million gallons of Hanford's tank waste and close the Tank Farms to protect the Columbia River. Our discussion of the Tank Farms and Waste Feed Delivery will cover progress made to date with Base and Recovery Act funding in reducing the risk posed by tank waste and in preparing for the initiation of waste treatment at Hanford. The millions of gallons of waste are a by-product of decades of plutonium production. After irradiated fuel rods were taken from the nuclear reactors to the processing facilities at Hanford they were exposed to a series of chemicals designed to dissolve away the rod, which enabled workers to retrieve the plutonium. Once those chemicals were exposed to the fuel rods they became radioactive and extremely hot. They also couldn't be used in this process more than once. Because the chemicals are caustic and extremely hazardous to humans and the environment, underground storage tanks were built to hold these chemicals until a more permanent solution could be found. The underground storage tanks range in capacity from 55,000 gallons to more than 1 million gallons. The tanks were constructed with carbon steel and reinforced concrete. There are eighteen groups of tanks, called 'tank farms', some having as few as two tanks and others up to sixteen tanks. Between 1943 and 1964, 149 single-shell tanks were built at Hanford in the 200 West and East Areas. Heat generated by the waste and the composition of the waste caused an estimated 67 of these single-shell tanks to leak into the ground. Washington River Protection Solutions is the prime contractor responsible for the safe management of this waste. WRPS' mission is to reduce the risk to the environment that is posed by the waste. All of the pumpable liquids have been removed from the single-shell tanks and transferred to the double-shell tanks. What remains in the single-shell tanks are solid and semi-solid wastes. Known as salt-cakes, they have the consistency of wet beach sand. Some of the waste resembles small broken ice, or whitish crystals. Because the original pumps inside the tanks were designed to remove only liquid waste, other methods have been developed to reach the remaining waste. Access to the tank waste is through long, typically skinny pipes, called risers, extending out of the tanks. It is through these pipes that crews are forced to send machines and devices into the tanks that are used to break up the waste or push it toward a pump. These pipes range in size from just a few inches to just over a foot in diameter because they were never intended to be used in this manner. As part of the agreement regulating Hanford cleanup, crews must remove at least 99% of the material in every tank on the site, or at least as much waste that can be removed based on available technology. To date, seven single-shell tanks have been emptied, and work is underway in another 10 tanks in preparation for additional retrieval activities. Two barriers have been installed over single-shell tanks to prevent the intrusion of surface water down to the tanks, with additional barriers planned for the future. Single and double-shell tank integrity analyses are ongoing. Because the volume of the waste generated through plutonium production exceeded the capacity of the single-shell tanks, between 1968 and 1986 Hanford engineers built 28 double-shell tanks. These tanks were studied and made with a second shell to surround the carbon steel and reinforced concrete. The double-shell tanks have not leaked any of their waste. (authors)

Fletcher, Thomas; Charboneau, Stacy; Olds, Erik [US DOE (United States)

2012-07-01T23:59:59.000Z

496

Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance  

E-Print Network [OSTI]

as: Wu: Drug metabolizing enzyme activities versus geneticRoles for Old Molecules: Enzymes in Personalized Medicine,Access Drug metabolizing enzyme activities versus genetic

Wu, Alan HB

2011-01-01T23:59:59.000Z

497

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Presentation by Patricia Hoffman of the Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request. OE's FY 2012 budget request represents a strong commitment to modernizing the grid and providing the reliable, affordable, and secure electric power needed to expand economic recovery enable sources Office of Electricity Delivery and Energy Reliability recovery, the transition to renewable energy sources, and achieve the President's clean energy goals. Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation More Documents & Publications

498

Tank Waste Feed Delivery System Readiness at the Hanford Site  

Broader source: Energy.gov (indexed) [DOE]

Audit Report Audit Report Tank Waste Feed Delivery System Readiness at the Hanford Site OAS-L-12-09 August 2012 Department of Energy Washington, DC 20585 August 23, 2012 MEMORANDUM FOR THE MANAGER, OFFICE OF RIVER PROTECTION FROM: David Sedillo, Director Western Audits Division Office of Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Tank Waste Feed Delivery System Readiness at the Hanford Site" BACKGROUND The Department of Energy's largest cleanup task involves the treatment, immobilization and disposal of 56 million gallons of hazardous and highly radioactive waste at the Hanford Site, located in Southeastern Washington State. As part of this effort, the Department is constructing

499

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Broader source: Energy.gov (indexed) [DOE]

March 28, 2012 March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C. 20585 OE Docket No. RRTT-IR-001 Submitted via email to: Lamont.Jackson@hq.doe.gov COMMENTS OF THE AMERICAN WIND ENERGY ASSOCIATION ON THE DEPARTMENT OF ENERGY'S REQUEST FOR INFORMATION RELATED TO THE PERMITTING OF TRANSMISSION LINES Dear Mr. Jackson, The American Wind Energy Association 1 (AWEA) appreciates the opportunity to provide comments to the Department of Energy's Office of Electricity Delivery and Energy Reliability (DOE) on its request for information

500

Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Permeability and Permeability and Integrity of Hydrogen Delivery Pipelines Z. Feng*, L.M. Anovitz*, J.G. Blencoe*, S. Babu*, and P. S. Korinko** * Oak Ridge National Laboratory * Savannah River National Laboratory August 30, 2005 2 OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY Partners and Collaborators * Oak Ridge National Laboratory - Project lead * Savannah River National Laboratory - Low H 2 pressure permeation test * Edison Welding Institute - Pipeline materials * Lincoln Electric Company - Welding electrode and weld materials for pipelines * Trans Canada - Commercial welding of pipelines and industry expectations * DOE Pipeline Working Group and Tech Team activities - FRP Hydrogen Pipelines - Materials Solutions for Hydrogen Delivery in Pipelines - Natural Gas Pipelines for Hydrogen Use