Sample records for targeted drug delivery

  1. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

    2012-08-28T23:59:59.000Z

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  2. Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery

    E-Print Network [OSTI]

    Tan, Mei Chee

    The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

  3. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01T23:59:59.000Z

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  4. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2011-04-28T23:59:59.000Z

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  5. Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme

    E-Print Network [OSTI]

    Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

    2006-01-01T23:59:59.000Z

    Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

  6. Controlling drug delivery across the placenta: A commentary

    E-Print Network [OSTI]

    Audus, Kenneth L.

    1999-01-01T23:59:59.000Z

    A challenge in modern drug therapy is to develop strategies for safer and more selective targeting of drug delivery in pregnancy. Specifically, approaches are needed that would restrict unnecessary drug exposure to either ...

  7. Mechanical loading impacts intramuscular drug transport : impact on local drug delivery

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2008-01-01T23:59:59.000Z

    Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue ...

  8. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01T23:59:59.000Z

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  9. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01T23:59:59.000Z

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  10. Drug delivery by organ-specific immunoliposomes

    SciTech Connect (OSTI)

    Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

    1990-01-01T23:59:59.000Z

    Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

  11. Synthesis and Characterization of a Magnetically Responsive Polymeric Drug Delivery System

    E-Print Network [OSTI]

    Yu, Shi

    A magnetic target drug delivery system consisting of biodegradable polymeric microspheres (poly D, L-lactic acid) loaded with magnetite nanoparticles (10-100 nm) and anticancer drug (paclitaxel) was studied. The magnetite ...

  12. Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs

    E-Print Network [OSTI]

    Stauber, Zachary Jason

    2012-01-01T23:59:59.000Z

    Two classes of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system ...

  13. A resorbable polymeric microreservoir device for controlled release drug delivery

    E-Print Network [OSTI]

    Grayson, Amy Catherine Richards, 1975-

    2003-01-01T23:59:59.000Z

    The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

  14. Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery

    E-Print Network [OSTI]

    Seto, Jennifer Elizabeth

    2011-01-01T23:59:59.000Z

    Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

  15. Transdermal microconduits by microscission for drug delivery and sample acquisition

    E-Print Network [OSTI]

    Gonzalez, Salvador

    Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

  16. Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2009-01-01T23:59:59.000Z

    An implantable rapid drug delivery device based on micro-electro-mechanical systems (MEMS) technology was designed, fabricated and validated for the in vivo rapid delivery of vasopressin in a rabbit model. In vitro ...

  17. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  18. Mechanism of Binding and Internalization of ICAM-1-derived Cyclic Peptides by LFA-1 on the Surface of T-cells: A Potential Method for Targeted Drug Delivery

    E-Print Network [OSTI]

    Anderson, Meagan E.; Siahaan, Teruna J.

    2003-10-01T23:59:59.000Z

    Purpose Peptides derived from the Domain 1 of the adhesion molecule ICAM-1(1-21) are being developed as targeting ligands for LFA-1 receptors expressed on activated T-cells. This work aims to elucidate the binding and ...

  19. E-Print Network 3.0 - advanced drug delivery Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nano-biomaterials, pharmaceuticals and drug delivery. They are exploring numerous... the pharmaceutical industry--the PTRC has created a novel inhaled drug delivery method that...

  20. Noninvasive quantification of drug delivery from an implantable MEMS device

    E-Print Network [OSTI]

    Johnson, Audrey M., 1976-

    2005-01-01T23:59:59.000Z

    (cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

  1. Needle-free drug delivery using shock wave techniques

    E-Print Network [OSTI]

    Pavlov, Atanas (Atanas Ivanov)

    2006-01-01T23:59:59.000Z

    A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

  2. A fully implantable intracochlear drug delivery device : development and characterization

    E-Print Network [OSTI]

    Swan, Erin Eileen Leary, 1976-

    2009-01-01T23:59:59.000Z

    In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

  3. Microcapsule drug delivery device for treatment of glioblastoma multiforme

    E-Print Network [OSTI]

    Scott, Alexander Wesley

    2010-01-01T23:59:59.000Z

    Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. ...

  4. Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang,

    E-Print Network [OSTI]

    Zhang, Liangfang

    Chapter 11 Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang, Robert Langer, and Omid C. Farokhzad Abstract The use of biodegradable polymeric nanoparticles. In cancer, targeted polymeric NPs can be used to deliver chemotherapies to tumor cells with greater efficacy

  5. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  6. Novel polyoxazolines polymer drug delivery platform

    E-Print Network [OSTI]

    performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

  7. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  8. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01T23:59:59.000Z

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  9. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

    2014-01-01T23:59:59.000Z

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  10. E-Print Network 3.0 - active drug delivery Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Clinic to introduce students to drug delivery, and in a senior-level elective... of the pharmaceutical industry today, with new drug ... Source: Hesketh, Robert - College of...

  11. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  12. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  13. Drug Delivery DOI: 10.1002/anie.201008053

    E-Print Network [OSTI]

    Tan, Weihong

    into MCF7 breast cancer cells. The As1411­ TMPyP4 complex was resistant to degradation and digestion to MCF7 cells than TMPyP4 itself.[24] Tan and co-workers have developed a DNA self-assembly strategy-quadruplex­aptamer delivery, the photo- sensitizer generated high toxicity to target cells and low toxicity to reference cells

  14. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    of a model compound, luciferin, from poly(lactic acid) (PLA) particles (approximately 250­350 nm in size nanoparticle could be engineered to target different cells.[3,6] PLA is an Food and Drug Administration (FDA with supercritical carbon dioxide (sc-CO2). PLA can also serve as a representative material for our process which can

  15. The dual-piston jet injector and the viability of drug delivery

    E-Print Network [OSTI]

    Cunningham, Daniel (Daniel P.)

    2007-01-01T23:59:59.000Z

    Drug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently ...

  16. Protein encapsulated magnetic carriers for micro/nanoscale drug delivery systems.

    SciTech Connect (OSTI)

    Xie, Y.; Kaminski, M. D.; Mertz, C. J.; Finck, M. R.; Guy, S. G.; Chen, H.; Rosengart, A. J.; Chemical Engineering; Univ. of Chicago, Pritzker School of Medicine

    2005-01-01T23:59:59.000Z

    Novel methods for drug delivery may be based on nanotechnology using non-invasive magnetic guidance of drug loaded magnetic carriers to the targeted site and thereafter released by external ultrasound energy. The key building block of this system is to successfully synthesize biodegradable, magnetic drug carriers. Magnetic carriers using poly(D,L-lactide-co-glycolide) (PLGA) or poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) as matrix materials were loaded with bovine serum albumin (BSA) by a double-emulsion technique. BSA-loaded magnetic microspheres were characterized for size, morphology, surface charge, and magnetization. The BSA encapsulation efficiency was determined by recovering albumin from the microspheres using dimethyl sulfoxide and 0.05N NaOH/0.5% SDS then quantifying with the Micro-BCA protein assay. BSA release profiles were also determined by the Micro-BCA protein assay. The microspheres had drug encapsulation efficiencies up to 90% depending on synthesis parameters. Particles were spherical with a smooth or porous surface having a size range less than 5 {mu}m. The surface charge (expressed as zeta potential) was near neutral, optimal for prolonged intravascular survival. The magnetization of these BSA loaded magnetic carriers was 2 to 6 emu/g, depending on the specific magnetic materials used during synthesis.

  17. Thermo-responsive Layer-by-Layer Assemblies for Nanoparticle-based Drug Delivery

    E-Print Network [OSTI]

    Zhou, Jing

    2013-11-26T23:59:59.000Z

    release in response to temperature is still challenging. Here, a thermo-responsive drug delivery system of solid dexamethasone nanoparticles (DXM NPs) encapsulated in a model LbL assembly of strong polyelectrolytes poly (diallyldimethylammonium chloride...

  18. Application of microfluidic emulsion technology to biochemistry, drug delivery and Lab-on-a-Chip programmability

    E-Print Network [OSTI]

    Urbanski, John Paul

    2005-01-01T23:59:59.000Z

    This research applies microfluidic emulsion technology to three diverse problems; biochemistry, drug delivery and lab-on-a-chip programmability. These subjects represent distinct research programs, but the underlying physics ...

  19. Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device

    E-Print Network [OSTI]

    Li, Yawen, 1972-

    2005-01-01T23:59:59.000Z

    The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release ...

  20. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  1. Specific and general binding in arterial drug delivery

    E-Print Network [OSTI]

    Levin, Andrew D. (Andrew David), 1976-

    2005-01-01T23:59:59.000Z

    Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

  2. Toward a drug delivery coating for intraocular lenses

    E-Print Network [OSTI]

    Smith, Rene Chivon

    2010-01-01T23:59:59.000Z

    Layer-by-layer assembly has become a quintessential tool for the creation of versatile, dynamic nanostructured materials able to dictate cellular behavior through exquisite surface functionality and delivery of bioactive ...

  3. Quantification of Mesenchymal Stem Cell (MSC) Delivery to a Target Site Using In Vivo Confocal Microscopy

    E-Print Network [OSTI]

    Mortensen, Luke J.

    The ability to deliver cells to appropriate target tissues is a prerequisite for successful cell-based therapy. To optimize cell therapy it is therefore necessary to develop a robust method of in vivo cell delivery ...

  4. A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

    E-Print Network [OSTI]

    Liu, David V.

    Protein-based methods of targeted short-interfering RNA (siRNA) delivery have the potential to solve some of the problems faced by nanoparticle-based methods, such as poor pharmacokinetics and biodistribution, low tumor ...

  5. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16T23:59:59.000Z

    +/- 10 nm were fabricated, characterized and then encapsulated in synthetic / biomacromolecule shell chitosan, dextran-sulfate using a layer by layer (LbL) self-assembly technique. Surface modifications were performed by covalently conjugating with poly...

  6. Targeted Drug Delivery To Leukocytes with ICAM-1 Derived Peptides

    E-Print Network [OSTI]

    Majumdar, Sumit

    2008-07-15T23:59:59.000Z

    cells by receptor mediated endocytosis and passive diffusion, respectively. High hydrophobicity of DOX-cIBR was proposed to be responsible for its energy-independent entry (chapter 2). To check the effect of hydrophobicity on internalization, two...

  7. Towards engineering hormone-binding globulins as drug delivery agents

    E-Print Network [OSTI]

    Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

    2014-11-26T23:59:59.000Z

    directly for destruction by the bodys immune system. There are currently three antibody-drug conjugates and 11 naked monoclonal antibodies approved by the Food and Drug Administration for the treatment of cancers [9, 10]. Another form of immunotherapy... efficacy in many cases [50]. Currently, the most common chemotherapeutic treatment for malignant metastatic prostate cancer is docetaxel, a mitotic poison [51]. In the next part of this proof-of-concept experiment, we sought to show that it is possible...

  8. Protein engineering for targeted delivery of radionuclides to tumors

    E-Print Network [OSTI]

    Orcutt, Kelly Davis

    2010-01-01T23:59:59.000Z

    Traditional cancer treatment strategies include systemic chemotherapy, external beam radiation, and surgical excision. Chemotherapy is nonspecific, and targets all rapidly dividing cells. External beam radiation and surgery ...

  9. CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data

    E-Print Network [OSTI]

    Frey, Pascal

    CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery t Enhanced condensational growth (ECG) is a newly proposed concept for respiratory drug delivery in which and evaluate a CFD model of ECG in a simple tubular geometry with direct comparisons to in vitro results

  10. Multiple-robot drug delivery strategy through coordinated teams of microswimmers

    SciTech Connect (OSTI)

    Kei Cheang, U; Kim, Min Jun, E-mail: mkim@coe.drexel.edu [Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania 19104 (United States); Lee, Kyoungwoo [Department of Computer Science, Yonsei University, Seoul 120-749 (Korea, Republic of); Julius, Anak Agung [Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)

    2014-08-25T23:59:59.000Z

    Untethered robotic microswimmers are very promising to significantly improve various types of minimally invasive surgeries by offering high accuracy at extremely small scales. A prime example is drug delivery, for which a large number of microswimmers is required to deliver sufficient dosages to target sites. For this reason, the controllability of groups of microswimmers is essential. In this paper, we demonstrate simultaneous control of multiple geometrically similar but magnetically different microswimmers using a single global rotating magnetic field. By exploiting the differences in their magnetic properties, we triggered different swimming behaviors from the microswimmers by controlling the frequency and the strength of the global field, for example, one swim and the other does not while exposed to the same control input. Our results show that the balance between the applied magnetic torque and the hydrodynamic torque can be exploited for simultaneous control of two microswimmers to swim in opposite directions, with different velocities, and with similar velocities. This work will serve to establish important concepts for future developments of control systems to manipulate multiple magnetically actuated microswimmers and a step towards using swarms of microswimmers as viable workforces for complex operations.

  11. A Universal Level Converter Towards the Realization of Energy Efficient Implantable Drug Delivery

    E-Print Network [OSTI]

    Mohanty, Saraju P.

    of the system which will then require a heat transfer mech- anism, affecting the portion of the body whereA Universal Level Converter Towards the Realization of Energy Efficient Implantable Drug Delivery and can block an input signal. We have prototyped a ULC using 32nm high-/metal-gate nano-CMOS technology

  12. Microfabrication-Compatible Nanoporous Gold Foams as Biomaterials for Drug Delivery

    E-Print Network [OSTI]

    Seker, Erkin

    Microfabrication-Compatible Nanoporous Gold Foams as Biomaterials for Drug Delivery Erkin Seker different samples: (i) 12 mm-diameter circular plain glass cover slips; (ii) 5 mm-diameter gold spots patterned on the glass cover slips; (iii) 5 mm-diameter np-Au spots patterned on the glass cover slips

  13. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26T23:59:59.000Z

    properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

  14. Alveolar targeting of aerosol pentamidine. Toward a rational delivery system

    SciTech Connect (OSTI)

    Simonds, A.K.; Newman, S.P.; Johnson, M.A.; Talaee, N.; Lee, C.A.; Clarke, S.W. (Royal Free Hospital, London (England))

    1990-04-01T23:59:59.000Z

    Nebulizer systems that deposit a high proportion of aerosolized pentamidine on large airways are likely to be associated with marked adverse side effects, which may lead to premature cessation of treatment. We have measured alveolar deposition and large airway-related side effects (e.g., cough, breathlessness, and effect on pulmonary function) after aerosolization of 150 mg pentamidine isethionate labeled with {sup 99m}Tc-Sn-colloid. Nine patients with AIDS were studied using three nebulizer systems producing different droplet size profiles: the Acorn System 22, Respirgard II, and Respirgard II with the inspiratory baffle removed. Alveolar deposition was greatest and side effects least with the nebulizer producing the smallest droplet size profile (Respirgard II), whereas large airway-related side effects were prominent and alveolar deposition lowest with the nebulizer producing the largest droplet size (Acorn System 22). Values for alveolar deposition and adverse airway effects were intermediate using the Respirgard with inspiratory baffle removed, thus indicating the importance of the baffle valve in determining droplet size. Addition of a similar baffle valve to the Acorn System 22 produced a marked improvement in droplet size profile. Selection of a nebulizer that produces an optimal droplet size range offers the advantage of enhancing alveolar targeting of aerosolized pentamidine while reducing large airway-related side effects.

  15. A safety and tolerability study of differently-charged nanoparticles for local pulmonary drug delivery

    SciTech Connect (OSTI)

    Harush-Frenkel, Oshrat [Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, 91120 (Israel); Bivas-Benita, Maytal [Beth Israel Deaconess Medical Center, Division of Viral Pathogenesis, Harvard Medical School, Boston, MA 02215 (United States); Nassar, Taher [Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, 91120 (Israel); Springer, Chaim [Institute of Pulmonology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120 (Israel); Sherman, Yoav [Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120 (Israel); Avital, Avraham [Institute of Pulmonology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120 (Israel); Altschuler, Yoram [School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, 91120 (Israel); Borlak, Jurgen [Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Strasse 1, 30625 Hannover (Germany); Benita, Simon, E-mail: benita@cc.huji.ac.i [Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, 91120 (Israel); David R. Bloom Center for Pharmacy at Hebrew University of Jerusalem (Israel)

    2010-07-15T23:59:59.000Z

    Nanoparticle (NP) based drug delivery systems provide promising opportunities in the treatment of lung diseases. Here we examined the safety and tolerability of pulmonary delivered NPs consisting of PEG-PLA as a function of particle surface charge. The rationale for such a comparison should be attributed to the differential pulmonary toxicity of positively and negatively charged PEG-PLA NP. Thus, the local and systemic effects of pulmonary administered NPs were investigated following 5 days of daily endotracheal instillation to BALB/c mice that were euthanized on the eighth or nineteenth day of the experiment. We collected bronchoalveolar lavages and studied hematological as well as histochemistry parameters. Notably, the cationic stearylamine based PEG-PLA NPs elicited increased local and systemic toxic effects both on the eighth and nineteenth day. In contrast, anionic NPs of similar size were much better tolerated with local inflammatory effects observed only on the eighth experimental day after pulmonary instillation. No systemic toxicity effect was observed although a moderate change was noted in the platelet count that was not considered to be of clinical significance. No pathological observations were detected in the internal organs following instillation of anionic NPs. Overall these observations suggest that anionic PEG-PLA NPs are useful pulmonary drug carriers that should be considered as a promising therapeutic drug delivery system.

  16. Computational analysis of biochemical networks for drug target identification and therapeutic intervention design

    E-Print Network [OSTI]

    Paudel, Nirmala

    2014-01-01T23:59:59.000Z

    Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear ...

  17. Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection

    SciTech Connect (OSTI)

    Daniela Rodica Radu

    2005-12-19T23:59:59.000Z

    The central theme of this dissertation is represented by the versatility of mesoporous silica nanomaterials in various applications such as catalysis and bio-applications, with main focus on biological applications of Mesoporous Silica Nanospheres (MSN). The metamorphosis that we impose to these materials from catalysis to sensing and to drug and gene delivery is detailed in this dissertation. First, we developed a synthetic method that can fine tune the amount of chemically accessible organic functional groups on the pores surface of MSN by exploiting electrostatic and size matching between the cationic alkylammonium head group of the cetyltrimethylammonium bromide (CTAB) surfactant and various anionic organoalkoxysilane precursors at the micelle-water interface in a base-catalyzed condensation reaction of silicate. Aiming nature imitation, we demonstrated the catalytic abilities of the MSNs, We utilized an ethylenediamine functional group for chelating Cu{sup 2+} as a catalytic functional group anchored inside the mesopores. Thus, a polyalkynylene-based conducting polymer (molecular wire) was synthesized within the Cu-functionalized MSNs silica catalyst. For sensing applications, we have synthesized a poly(lactic acid) coated mesoporous silica nanosphere (PLA-MSN) material that serves as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. We exploited the mesoporosity of MSNs for encapsulating pharmaceutical drugs. We examined bio-friendly capping molecules such as polyamidoamine dendrimers of generations G2 to G4, to prevent the drug leaching. Next, the drug delivery system employed MSNs loaded with Doxorubicin, an anticancer drug. The results demonstrated that these nano-Trojan horses have ability to deliver Doxorubicin to cancer cells and induce their death. Finally, to demonstrate the potential of MSN as an universal cellular transmembrane nanovehicle, we anchored positively charged dendrimers on the surface of MSN and utilize them to complex cationic DNA. The p-EGFP-CI gene-coated MSN nanocomposite was able to transfect cancer cell lines, such as human HeLa and CHO cancer cell lines. The gene carrier ability of MSNs was further proved by transfecting primary cells and cotransfecting of two different genes in cancer cell lines. In sum, MSN are versatile partners in several types of applications.

  18. Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung

    SciTech Connect (OSTI)

    Dailey, L.A. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany)]. E-mail: lea_ann.dailey@kcl.ac.uk; Jekel, N. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Fink, L. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Gessler, T. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Schmehl, T. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany); Wittmar, M. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany); Kissel, T. [Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg (Germany); Seeger, W. [University of Giessen Lung Center (UGLC), D-35392 Giessen (Germany)

    2006-08-15T23:59:59.000Z

    Particulate nanocarriers have been praised for their advantageous drug delivery properties in the lung, such as avoidance of macrophage clearance mechanisms and long residence times. However, instilled non-biodegradable polystyrene nanospheres with small diameters and thus large surface areas have been shown to induce pulmonary inflammation. This study examines the potential of biodegradable polymeric nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) and the novel PLGA derivative, diethylaminopropylamine polyvinyl alcohol-grafted-poly(lactic-co-glycolic acid) (DEAPA-PVAL-g-PLGA), to provoke inflammatory responses in the murine lung after intratracheal instillation. Lactate dehydrogenase (LDH) release, protein concentration, MIP-2 mRNA induction, and polymorphonucleocyte (PMN) recruitment in the bronchial alveolar lavage fluid (BALF) were used to evaluate an inflammatory response in Balb-C mice. Two sizes of polystyrene (PS) nanospheres (diameters: 75 nm and 220 nm) were included in the study for comparison. All nanoparticle suspensions were instilled at concentrations of 1 {mu}g/{mu}l and 2.5 {mu}g/{mu}l, representative of an estimated 'therapeutic dose' and a concentrated 'dose' of particles. In all experiments, the 75 nm PS particles exhibited elevated responses for the inflammatory markers investigated. In contrast, biodegradable particles of comparable hydrodynamic diameter showed a significantly lower inflammatory response. The most marked differences were observed in the extent of PMN recruitment. While the 75 nm and 220 nm PS nanospheres exhibited 41 and 74% PMN within the total BALF cell population after 24 h, respectively, PMN recruiting in lungs instilled with both types of biodegradable particles did not exceed values of the negative isotonic glucose control. In conclusion, evidence suggests that biodegradable polymeric nanoparticles designed for pulmonary drug delivery may not induce the same inflammatory response as non-biodegradable polystyrene particles of comparable size.

  19. Local Delivery System of Immune Modulating Drug for Unresectable Adenocarcinoma: In Vitro Experimental Study and In Vivo Animal Study

    SciTech Connect (OSTI)

    Lee, Don Haeng [Inha University, College of Medicine, Department of Internal Medicine (Korea, Republic of); Kang, Sung-Gwon [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of)], E-mail: gangsg@radiol.snu.ac.kr; Jeong, Seok [Inha University, College of Medicine, Department of Internal Medicine (Korea, Republic of); Yoon, Chang Jin; Choi, Jung-Ah [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of); Byun, Ju Nam [Chosun University, College of Medicine, Department of Radiology (Korea, Republic of); Park, Jae Hyung [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of); Lee, Kyu Back [Korea University, College of Medicine, Department of Biomedical Engineering (Korea, Republic of)

    2006-10-15T23:59:59.000Z

    The purpose of the study was to evaluate the efficacy and safety of a developed drug delivery system containing OK-432 through in vitro and animal study. An OK-432-impregnated polycarbonate/polyurethane stent membrane was used to develop a drug delivery system (DDS) enabling the locoregional release of OK-432. Polyethyleneglycol was used as a detergent and porosity generator. The stability of OK-432 in solvent, releasing kinetics of drug, and cytotoxicity of the DDS were evaluated. OK-432-impregnated DDS was implanted in mice in which a human adenocarcinoma cell line was injected and grown in their back. Flow cytometry and enzyme-linked immunosorbent assay were used for quantifying the amount of drug. OK-432 exposed to phosphate-buffered saline and OK-432 exposed to N,N-dimethylacetamide showed similar results on dot graphs and histograms. However, OK-432 exposed to tetrahydrofurane showed different dot graphs and histograms, which means that the antigenicity of the drug was changed. The release rate of OK-432 was maintained at a constant level for 6 weeks. The local delivery of OK-432 was found to have an antitumor effect on a human adenocarcinoma cell line in an animal study, but no effect on this cell line in in vitro cell culture. Histologic examination showed minimal inflammatory reaction in surrounding tissue. Our study shows that local treatment using this OK-432 release system is safe and effective in reducing adenocarcinoma in a mouse model.

  20. Hepatic Stellate CellTargeted Delivery of Hepatocyte Growth Factor Transgene via Bile Duct Infusion Enhances Its Expression at Fibrotic Foci to Regress Dimethylnitrosamine-Induced Liver Fibrosis

    E-Print Network [OSTI]

    Narmada, Balakrishnan Chakrapani

    Liver fibrosis generates fibrotic foci with abundant activated hepatic stellate cells and excessive collagen deposition juxtaposed with healthy regions. Targeted delivery of antifibrotic therapeutics to hepatic stellate ...

  1. REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila

    E-Print Network [OSTI]

    Perrimon, Norbert

    the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery studies over the years has relied on the ease of growing this organism and the powerful genetic tools such as the insulin, epidermal growth factor, transforming growth factor b, Wnt, Hedgehog, JAK/STAT and Notch pathways

  2. Development of Novel Polymeric Materials for Gene Therapy and pH-Sensitive Drug Delivery: Modeling, Synthesis, Characterization, and Analysis

    SciTech Connect (OSTI)

    Brian Curtis Anderson

    2002-08-27T23:59:59.000Z

    The underlying theme of this thesis is the use of polymeric materials in bioapplications. Chapters 2-5 either develop a fundamental understanding of current materials used for bioapplications or establish protocols and procedures used in characterizing and synthesizing novel materials. In chapters 6 and 7 these principles and procedures are applied to the development of materials to be used for gene therapy and drug delivery. Chapter one is an introduction to the ideas that will be necessary to understand the subsequent chapters, as well as a literature review of these topics. Chapter two is a paper that has been published in the ''Journal of Controlled Release'' that examines the mechanism of drug release from a polymer gel, as well as experimental design suggestions for the evaluation of water soluble drug delivery systems. Chapter three is a paper that has been published in the ''Journal of Pharmaceutical Sciences'' that discusses the effect ionic salts have on properties of the polymer systems examined in chapter two. Chapter four is a paper published in the Materials Research Society Fall 2000 Symposium Series dealing with the design and synthesis of a pH-sensitive polymeric drug delivery device. Chapter five is a paper that has been published in the journal ''Biomaterials'' proposing a novel polymer/metal composite for use as a biomaterial in hip arthroplasty surgery. Chapter six is a paper that will appear in an upcoming volume of the Journal ''Biomaterials'' dealing with the synthesis of a novel water soluble cationic polymer with possible applications in non-viral gene therapy. Chapter seven is a paper that has been submitted to ''Macromolecules'' discussing several novel block copolymers based on poly(ethylene glycol) and poly(diethylamino ethyl methacrylate) that possess both pH-sensitive and temperature sensitive properties. Chapter eight contains a summary of the research contained in chapters 2-7 and proposes future research for the gene therapy and drug delivery projects.

  3. Kilogram Scale Synthesis of a Triazine-based Dendrimer and the Development of a General Strategy for the Installation of Pharmacophores to Yield Potential Drug Delivery Agents

    E-Print Network [OSTI]

    Venditto, Vincent J.

    2011-02-22T23:59:59.000Z

    KILOGRAM SCALE SYNTHESIS OF A TRIAZINE-BASED ENDRIMER AND THE DEVELOPMENT OF A GENERAL STRATEGY FOR THE INSTALATION OF PHARMACOPHORES TO YIELD POTENTIAL DRUG DELIVERY AGENTS A Disertation by VINCENT JOSEPH VENDITO Submited... AND THE DEVELOPMENT OF A GENERAL STRATEGY FOR THE INSTALATION OF PHARMACOPHORES TO YIELD POTENTIAL DRUG DELIVERY AGENTS A Disertation by VINCENT JOSEPH VENDITO Submited to the Ofice of Graduate Studies of Texas A&M University in partial fulfilment...

  4. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassiveSubmittedStatusButler Tina ButlerToday inm"Topo II: An Enzyme Target for

  5. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2Topo II: An Enzyme Target for Antibacterial and Cancer

  6. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2Topo II: An Enzyme Target for Antibacterial and

  7. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2Topo II: An Enzyme Target for Antibacterial andTopo II:

  8. Liquid Hydrogen Delivery - Strategic Directions for Hydrogen...

    Broader source: Energy.gov (indexed) [DOE]

    Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

  9. Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles

    SciTech Connect (OSTI)

    Lammert, M. P.; Burton, J.; Sindler, P.; Duran, A.

    2014-10-01T23:59:59.000Z

    This research project compares laboratory-measured fuel economy of a medium-duty diesel powered hydraulic hybrid vehicle drivetrain to both a conventional diesel drivetrain and a conventional gasoline drivetrain in a typical commercial parcel delivery application. Vehicles in this study included a model year 2012 Freightliner P100H hybrid compared to a 2012 conventional gasoline P100 and a 2012 conventional diesel parcel delivery van of similar specifications. Drive cycle analysis of 484 days of hybrid parcel delivery van commercial operation from multiple vehicles was used to select three standard laboratory drive cycles as well as to create a custom representative cycle. These four cycles encompass and bracket the range of real world in-use data observed in Baltimore United Parcel Service operations. The NY Composite cycle, the City Suburban Heavy Vehicle Cycle cycle, and the California Air Resources Board Heavy Heavy-Duty Diesel Truck (HHDDT) cycle as well as a custom Baltimore parcel delivery cycle were tested at the National Renewable Energy Laboratory's Renewable Fuels and Lubricants Laboratory. Fuel consumption was measured and analyzed for all three vehicles. Vehicle laboratory results are compared on the basis of fuel economy. The hydraulic hybrid parcel delivery van demonstrated 19%-52% better fuel economy than the conventional diesel parcel delivery van and 30%-56% better fuel economy than the conventional gasoline parcel delivery van on cycles other than the highway-oriented HHDDT cycle.

  10. E-Print Network 3.0 - anticancer drug delivery Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Chemistry, University of Utah Collection: Chemistry 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

  11. Optimal periodic control of a drug delivery system Subbarao Varigonda 1

    E-Print Network [OSTI]

    Georgiou, Tryphon T.

    drug infusion strategies for maximizing a time averaged measure of drug effect are investigated infusion provides a locally improved average effect compared to steady infusion are characterized using 1­2 hr), as steady infusion leads to nearly complete sup- pression of gonadal function [24

  12. Genome-Free Viral Capsids for Targeted Drug Delivery to Breast Cancer

    E-Print Network [OSTI]

    Wu, Wesley

    2012-01-01T23:59:59.000Z

    Water (ddH 2 O) used in biological procedures or as a reaction solvent was deionized using a NANOpure TM purification system (Water (ddH 2 O) used in biologi- cal procedures or as a reaction solvent was deionized using a NANOpure TM purification system (

  13. Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme

    E-Print Network [OSTI]

    Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

    2006-01-01T23:59:59.000Z

    D. F. , Kahl, S. B. , Bjornstad, K. A. , Bauer, W. F. ,L. , Blakely, E. A. , Bjornstad, K. A. , Deen, D. F. ,Blakely 2 , Kathleen A. Bjornstad 2 , Xiao Shu 3 ,Thomas F.

  14. Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery

    E-Print Network [OSTI]

    Snow, Merideth

    2010-07-14T23:59:59.000Z

    laboratory has shown that treating the cancer cells with a novel dendrimer construct (G2-NH2) alone, without drug or DNA present, can be cytotoxic. The purpose of this study was to test the next generation of dendrimers for the ability to deliver DNA...

  15. Multiwaveguide implantable probe for light delivery to sets of distributed brain targets

    E-Print Network [OSTI]

    Zorzos, Anthony Nicholas

    Optical fibers are commonly inserted into living tissues such as the brain in order to deliver light to deep targets for neuroscientific and neuroengineering applications such as optogenetics, in which light is used to ...

  16. Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.

    2012-08-31T23:59:59.000Z

    was found to induce marked tumor regression. The discovery of nitrogen mustard as a novel anticancer drug resulted in a great deal of optimism that cancer could finally be cured. A burst of research activity to develop new anticancer drugs therefore... of activity against normal cells. Indeed, many novel anticancer agents continue to be identified, but few find clinical utility due to unacceptable toxicity [17], a clear indicator that there is a need for a screening approach that can identify potent drugs...

  17. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01T23:59:59.000Z

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: A novel computational framework was developed for mechanistic study of SADRs. Off-targets of drugs were identified in large scale and in a high-throughput manner. SADRs like cardiac disorders were systematically explored in molecular networks. A number of ADR-associated proteins were identified.

  18. A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy

    E-Print Network [OSTI]

    Valencia, Pedro M. (Pedro Miguel)

    2013-01-01T23:59:59.000Z

    The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

  19. Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion

    SciTech Connect (OSTI)

    Knobloch, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland); Portier, C.J. [Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 (United States); Levionnois, O.L. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Theurillat, R. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Thormann, W. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Spadavecchia, C. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Mevissen, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland)]. E-mail: meike.mevissen@vpi.unibe.ch

    2006-11-01T23:59:59.000Z

    Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

  20. Gaseous Hydrogen Delivery Breakout- Strategic Directions for Hydrogen Delivery Workshop

    Broader source: Energy.gov [DOE]

    Targets, barriers and research and development priorities for gaseous delivery of hydrogen through hydrogen and natural gas pipelines.

  1. E-Print Network 3.0 - antibiotic drug targets Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    aureus1 Summary: or lack the target of the antibiotic. b | Multidrug resistance efflux pumps. These pumps secrete... modify the target protein, for example by disabling the...

  2. Articulating feedstock delivery device

    DOE Patents [OSTI]

    Jordan, Kevin

    2013-11-05T23:59:59.000Z

    A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

  3. E-Print Network 3.0 - anticancer drug targets Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    University of Toronto Collection: Biology and Medicine 2 Robotic-Lab.COM Nanotechnology boosts anticancer drug cocktail many times over http:www.robotic-lab.comen...

  4. Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive

    E-Print Network [OSTI]

    Gao, Jinming

    Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems describe the development of multifunctional polymeric micelles with cancer-targeting capability via rv 3 and rv 3-specific cytotoxic response of these multifunctional polymeric micelles. Over the past several

  5. Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery

    E-Print Network [OSTI]

    Vukmirovic, Neda

    2007-01-01T23:59:59.000Z

    Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

  6. antirheumatic drugs dmards: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  7. antineoplastic drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  8. antineoplastic drugs chimio-radiotherapie: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  9. Frontiers in Disease Therapies UCSB's integration of critical aspects of biological engineering (drug delivery, systems biology, biomateri-

    E-Print Network [OSTI]

    Akhmedov, Azer

    the many diseases that UCSB has cross-disciplinary efforts in, including cancer, diabetes, PTSD, Alzheimer targeting therapeutics to cancer cells while sparing healthy ones. In cancer and diabetes, another failure diabetic patients using closed-loop devices in clinical trials. For more insight into our approach

  10. Drug Target Optimization in Chronic Myeloid Leukemia Using Innovative Computational Platform

    E-Print Network [OSTI]

    Chuang, Ryan; Hall, Benjamin A.; Benque, David; Cook, Byron; Ishtiaq, Samin; Piterman, Nir; Taylor, Alex; Vardi, Moshe; Koschmieder, Steffen; Gottgens, Berthold; Fisher, Jasmin

    2015-02-03T23:59:59.000Z

    L, proliferation was reduced in the CP CML state and apoptosis induced, consistent with results found by Seo et al29. Proliferation was slowed in the BC CML state from 2 to 1 and apoptosis increased to 1, but otherwise remained the same as the baseline BC CML... | 5 : 8190 | DOI: 10.1038/srep08190 8 28. Zhao, X. M. et al. Prediction of drug combinations by integrating molecular and pharmacological data. PLoS computational biology 7, e1002323, doi:10.1371/ journal.pcbi.1002323 (2011). 29. Seo, J. H. et al. A...

  11. Vaccine delivery with microneedle skin patches in nonhuman primates

    E-Print Network [OSTI]

    Li, Adrienne V

    Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics ...

  12. Fractalkine Targeting with a Receptor-Mimicking Peptide-Amphiphile

    E-Print Network [OSTI]

    Kokkoli, Efie

    . Kasinskas, Anastasia Mardilovich, and Ashish Garg Department of Chemical Engineering and Materials Science drug delivery systems driven by a strong need in clinical practice. Advances in materials science to the target tissue.2 Liposomes have been investigated extensively and long-circulating liposomes (stealth lipo

  13. Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery...

    Broader source: Energy.gov (indexed) [DOE]

    Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

  14. anti-parkinsonian drug selegiline: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  15. Liguid and Solid Carriers Group- Strategic Directions for Hydrogen Delivery Workshop

    Broader source: Energy.gov [DOE]

    Targets, barriers and research and development priorities for solid and liquid hydrogen storage and delivery materials.

  16. Self-assembled pentablock copolymers for selective and sustained gene delivery

    SciTech Connect (OSTI)

    Zhang, Bingqi

    2011-05-15T23:59:59.000Z

    The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

  17. Development and Testing of Simulation (Game) to Illustrate Basic Principles of Integrated Project Delivery and Target Value Design: A First Run Study

    E-Print Network [OSTI]

    Munankami, Manish 1972-

    2012-12-07T23:59:59.000Z

    : a. American Companies, especially GE, used VE in their product designs during World War II around 1940. b. Toyota adopted the VE model from the Americans and developed it into a profit planning tool called Target Costing during 1960. c...

  18. Measured Laboratory and In-Use Fuel Economy Observed over Targeted Drive Cycles for Comparable Hybrid and Conventional Package Delivery Vehicles

    SciTech Connect (OSTI)

    Lammert, M. P.; Walkowicz, K.; Duran, A.; Sindler, P.

    2012-10-01T23:59:59.000Z

    In-use and laboratory-derived fuel economies were analyzed for a medium-duty hybrid electric drivetrain with 'engine off at idle' capability and a conventional drivetrain in a typical commercial package delivery application. Vehicles studied included eleven 2010 Freightliner P100H hybrids in service at a United Parcel Service facility in Minneapolis during the first half of 2010. The hybrids were evaluated for 18 months against eleven 2010 Freightliner P100D diesels at the same facility. Both vehicle groups use the same 2009 Cummins ISB 200-HP engine. In-use fuel economy was evaluated using UPS's fueling and mileage records, periodic ECM image downloads, and J1939 CAN bus recordings during the periods of duty cycle study. Analysis of the in-use fuel economy showed 13%-29% hybrid advantage depending on measurement method, and a delivery route assignment analysis showed 13%-26% hybrid advantage on the less kinetically intense original diesel route assignments and 20%-33% hybrid advantage on the more kinetically intense original hybrid route assignments. Three standardized laboratory drive cycles were selected that encompassed the range of real-world in-use data. The hybrid vehicle demonstrated improvements in ton-mi./gal fuel economy of 39%, 45%, and 21% on the NYC Comp, HTUF Class 4, and CARB HHDDT test cycles, respectively.

  19. Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport

    E-Print Network [OSTI]

    Tang, Hua, 1972-

    2002-01-01T23:59:59.000Z

    Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

  20. E-Print Network 3.0 - amplifies stent-based drug Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    IN STENT-BASED DRUG DELIVERY Giuseppe Pontrelli*, Filippo de Monte** *IAC... . Hwang, D. Wu, E.R. Edelman, Physiological transport forces govern drug...

  1. E-Print Network 3.0 - anticancer drug pump Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology Summary: drug efflux pumps, increasing drug metabolism, enhancing self-repairing ability or expressing altered......

  2. Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth

    E-Print Network [OSTI]

    Wong, Cliff R. (Cliff Richard)

    2011-01-01T23:59:59.000Z

    Assembly of functional nanocomponents offers promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery ...

  3. Targeting nanodisks via a single chain variable antibody - Apolipoprotein chimera

    SciTech Connect (OSTI)

    Iovannisci, David M.; Beckstead, Jennifer A. [Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609 (United States); Ryan, Robert O. [Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609 (United States)], E-mail: rryan@chori.org

    2009-02-06T23:59:59.000Z

    Nanodisks (ND) are nanometer scale complexes of phospholipid and apolipoprotein that have been shown to function as drug delivery vehicles. ND harboring significant quantities of the antifungal agent, amphotericin B, or the bioactive isoprenoid, all trans retinoic acid, have been generated and characterized. As currently formulated, ND possess limited targeting capability. In this study, we constructed a single chain variable antibody (scFv).apolipoprotein chimera and assessed the ability of this fusion protein to form ND and recognize the antigen to which the scFv is directed. Data obtained revealed that {alpha}-vimentin scFv.apolipoprotein A-I is functional in ND formation and antigen recognition, opening the door to the use of such chimeras in targeting drug-enriched ND to specific tissues.

  4. Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2007-01-01T23:59:59.000Z

    Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

  5. Drug delivery device for bladder disorders

    E-Print Network [OSTI]

    Lee, Heejin, 1976-

    2009-01-01T23:59:59.000Z

    Several pathologies associated with the bladder have wide impacts on society. Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are chronic urological conditions characterized by pain, ...

  6. Physicochemical investigations of a drug delivery oscillator

    E-Print Network [OSTI]

    Bhalla, A. S.; Siegel, R. A.

    2006-10-27T23:59:59.000Z

    75 mM Glucose/10 % MAA /kmarble= 0.00199 s-1 I = 50 mM (50 mM NaCl+0 mM CaCl2) I = 95 mM (50 mM NaCl + 15 mM CaCl2) I = 155 mM (50 mM NaCl+ 35 mM CaCl2) I = 155 mM (155 mM NaCl+ 0 mM CaCl2) p H Device Membrane - Hydrogel N...4.6 4.7 4.8 4.9 5 5.1 5.2 5.3 5.4 0 0.2 0.4 0.6 0.8 1 Time (Days) p H Glucose Gluconic acid Gluconic acid Gluconate- + H+ H+ + CaCO3 Ca 2+ + HCO3- H+ + HCO3- H2CO3 pKa = 6.37 H2CO3 CO2 ? + H2O pKa = 3.6 ? Buffer Build-Up Affects...

  7. Gaseous Hydrogen Delivery Breakout - Strategic Directions for...

    Broader source: Energy.gov (indexed) [DOE]

    Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop...

  8. Development of an interleukin 2 receptor targeted gene therapy vehicle

    E-Print Network [OSTI]

    Wattanakaroon, Wanida

    2006-08-16T23:59:59.000Z

    antibody to the IL-2R was used to target the oligonucleotide delivery vehicle which consisted of a polyamidoamine dendrimer. Optimization of the delivery vehicle involves understanding the factors that govern its association with oligonucleotide...

  9. Current Drug Targets, 2006, 7, 000-000 1 1389-4501/06 $50.00+.00 2006 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    and bring about a prolonged effect. By its binding to plasmatic proteins, resveratrol also exhibits a prolonged effect. Interestingly, low doses of res- veratrol can sensitize to low doses of cytotoxic drugs or chemotherapeutic strategies and is believed to be a novel weapon for new therapeutic strategies. Key Words

  10. Gaseous Hydrogen Delivery Breakout

    E-Print Network [OSTI]

    Gaseous Hydrogen Delivery Breakout Strategic Directions for Hydrogen Delivery Workshop May 7 detection Pipeline Safety: odorants, flame visibility Compression: cost, reliability #12;Breakout Session goal of a realistic, multi-energy distribution network model Pipeline Technology Improved field

  11. adeno-associated virus-mediated delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for Different Contexts Tayeb Lemlouma1 and Nabil Layada2 OPERA Project present a framework which allows adapted content delivery for different target contexts. This...

  12. Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other...

    Broader source: Energy.gov (indexed) [DOE]

    Assumes 2005 delivery technologies * We can insert our Research Targets to see the impact Hydrogen Plants can be Located Relatively Near the Market demand Nearly all areas East of...

  13. Evaluation of Retrofit Delivery Packages

    SciTech Connect (OSTI)

    Berman, M.; Smith, P.; Porse, E.

    2013-07-01T23:59:59.000Z

    Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

  14. Hydrogen Delivery Liquefaction & Compression

    E-Print Network [OSTI]

    Hydrogen Delivery Liquefaction & Compression Raymond Drnevich Praxair - Tonawanda, NY Strategic Initiatives for Hydrogen Delivery Workshop - May 7, 2003 #12;2 Agenda Introduction to Praxair Hydrogen Liquefaction Hydrogen Compression #12;3 Praxair at a Glance The largest industrial gas company in North

  15. Hydrogen Delivery Options and Issues

    Broader source: Energy.gov (indexed) [DOE]

    Eastman Chemical Ferco AEP Thermochem Entergy GE Framatome Stuart Energy APCi Chevron Praxair Exxonmobil BOC BP H2A Delivery Goals * Develop spreadsheet database on delivery...

  16. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

    E-Print Network [OSTI]

    Sahay, Gaurav

    Despite efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain unclear. Here we examine cellular uptake of short ...

  17. Targeting of drugs and nanoparticles to tumors

    E-Print Network [OSTI]

    Ruoslahti, Erkki

    The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as ...

  18. Hydrogen Delivery - Basics | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Delivery Hydrogen Delivery - Basics Hydrogen Delivery - Basics Photo of light-duty vehicle at hydrogen refueling station. Infrastructure is required to move hydrogen from the...

  19. Experimental and computational investigations of therapeutic drug release from biodegradable poly(lactide-co-glycolide) (plg) microspheres

    E-Print Network [OSTI]

    Berchane, Nader Samir

    2009-05-15T23:59:59.000Z

    The need to tailor release-rate profiles from polymeric microspheres remains one of the leading challenges in controlled drug delivery. Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a...

  20. Investigation of Degradation Properties of Poly(lactide-co-glycolide) Matrix for Anticancer Agent Delivery

    SciTech Connect (OSTI)

    Ghani, S. M.; Mohamed, M. S. W.; Yahya, A. F.; Noorsal, K. [Advanced Materials Research Centre (AMREC), SIRIM Berhad, Lot 34, Jalan Hi-Tech 2/3, Kulim Hi-Tech Park, 09000 Kulim Kedah (Malaysia)

    2010-03-11T23:59:59.000Z

    Poly(lactide-co-glycolide)(PLA{sub 50}GA{sub 50}) is a biodegradable and biocompatible polymer. It offers tremendous potential as a basis for drug delivery, either as drug delivery system alone or in conjugate with a medical device. The PLA{sub 50}GA{sub 50} is the material of choice for relatively shorter-duration applications, while the homopolymer PLA (poly-L-lactide) and PGA (polyglycolide) are preferred for longer term delivery of drugs. This paper discusses the degradation properties of poly(lactide-co-glycolide)(PLA{sub 50}GA{sub 50}) at inherent viscosity of 0.89 dL/g as preliminary studies for anticancer agent delivery.

  1. STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 2009/109/109/109/10 Annual Delivery Report

    E-Print Network [OSTI]

    STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 2009/109/109/109/10 0 Annual Delivery Report 2009/10 August 2010 #12;STFC Annual Delivery Plan Report 200STFC Annual Delivery Plan Report 200STFC Annual Delivery

  2. Hydrogen Delivery Mark Paster

    E-Print Network [OSTI]

    Liquids (e.g. ethanol etc.) ­ Truck: HP Gas & Liquid Hydrogen ­ Regional Pipelines ­ Breakthrough Hydrogen;Delivery Key Challenges · Pipelines ­ Retro-fitting existing NG pipeline for hydrogen ­ Utilizing existing NG pipeline for Hythane with cost effective hydrogen separation technology ­ New hydrogen pipeline

  3. Hydrogen Delivery- Current Technology

    Broader source: Energy.gov [DOE]

    Hydrogen is transported from the point of production to the point of use via pipeline, over the road in cryogenic liquid trucks or gaseous tube trailers, or by rail or barge. Read on to learn more about current hydrogen delivery and storage technologies.

  4. Target isolation system, high power laser and laser peening method and system using same

    DOE Patents [OSTI]

    Dane, C. Brent (Livermore, CA); Hackel, Lloyd A. (Livermore, CA); Harris, Fritz (Rocklin, CA)

    2007-11-06T23:59:59.000Z

    A system for applying a laser beam to work pieces, includes a laser system producing a high power output beam. Target delivery optics are arranged to deliver the output beam to a target work piece. A relay telescope having a telescope focal point is placed in the beam path between the laser system and the target delivery optics. The relay telescope relays an image between an image location near the output of the laser system and an image location near the target delivery optics. A baffle is placed at the telescope focal point between the target delivery optics and the laser system to block reflections from the target in the target delivery optics from returning to the laser system and causing damage.

  5. Hydrogen Delivery Liquefaction and Compression

    Broader source: Energy.gov [DOE]

    Hydrogen Delivery Liquefaction and Compression - Overview of commercial hydrogen liquefaction and compression and opportunities to improve efficiencies and reduce cost.

  6. Aggressive Underwriting and Smart Program Delivery | Department...

    Energy Savers [EERE]

    Aggressive Underwriting and Smart Program Delivery Aggressive Underwriting and Smart Program Delivery Presents information about loan underwriting funding approaches and...

  7. Identification and characterization of receptor-specific peptides for siRNA delivery

    E-Print Network [OSTI]

    Ren, Yin

    Tumor-targeted delivery of siRNA remains a major barrier in fully realizing the therapeutic potential of RNA interference. While cell-penetrating peptides (CPP) are promising siRNA carrier candidates, they are universal ...

  8. Assessing the impact of tumor evolution on oncology drug development and commercialization

    E-Print Network [OSTI]

    Sterk, Joseph P. (Sterk, Joseph Phillip)

    2011-01-01T23:59:59.000Z

    This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...

  9. Apatite-Polymer Composites for the Controlled Dual Delivery of BMP-2 and BMP-6 for Bone Tissue Engineering

    E-Print Network [OSTI]

    Yong, Tseh-Hwan

    The release of growth factors from tissue engineering scaffolds provides signals that influence the migration, differentiation, and proliferation of cells. The incorporation of a drug delivery platform that is capable of ...

  10. Timely delivery of LIFE Tom Anklam, Lawrence Livermore

    E-Print Network [OSTI]

    Timely delivery of LIFE Tom Anklam, Lawrence Livermore National Laboratory October 19, 2011 LIFE_Royal_Society_9/7/11 6 LIFE Fusion Chamber is About the Same Scale as the NIF Target Chamber #12;LIFE Fusion Physics will be Demonstrated on the NIF #12;LIFE will use a modular laser architeccture #12;#12;#12;11 NIF

  11. TIGER -- A technology to improve the delivery capability of nuclear bombs and the survivability of the delivery aircraft

    SciTech Connect (OSTI)

    NONE

    1980-12-31T23:59:59.000Z

    The TIGER (Terminal guided and Extended-Range) Program was initiated in 1972 to study improved delivery capabilities for stockpiled tactical nuclear bombs. The Southeast Asia conflict fostered the development of air-delivered standoff conventional weapons utilizing terminal guidance systems. SNL initiated the TIGER program to determine if current nuclear bombs could be provided with a similarly accurate standoff capabilities. These conventional weapon delivery techniques, while allowing highly accurate attack, generally require entering the target area at high altitude to establish line of sight to the target. In parallel with the TIGER program, system studies analyzed this concept and showed marked improvement in aircraft and weapon survivability with moderate standoff (10--20 km) if low level deliveries (60 m) could be accomplished. As a result of this work, the TIGER program was redirected in early 1974 to demonstrate a standoff bomb with good accuracy (90 m CEP) when delivered from low flying aircraft. This program redirection resulted in the selection of an inertial guidance system to replace the earlier terminal guidance systems. This program was called the Extended-Range Bomb (ERB). In May 1974, a joint Air Force/DOE study identified the desirability of having a single tactical weapon which could be employed against either fixed, preselected targets, or mobile battlefield targets. Studies conducted on the ERB system showed that the inertially guided weapon could fly not only the standoff mission but also a return-to-target mission against the mobile battlefield targets whose locations are not known accurately enough to use a standoff delivery. The ERB program evolved from these initial investigations into an exploratory program to develop the hardware and demonstrate the technology required to fly standoff and return-to-target trajectories. The application of this technology in the form of field retrofit kits to the B61 bomb is called TIGER II.

  12. Functionalization of nanocarriers for efficient combination drug delivery

    E-Print Network [OSTI]

    Hu, Che-Ming Jack

    2011-01-01T23:59:59.000Z

    the-art synthetic stealth materials. Biodistribution studystealth moieties can be developed to mimic our bodies endogenous materials

  13. Silicon microneedles array with biodegradable tips for transdermal drug delivery

    E-Print Network [OSTI]

    Chen, B; Tay, Francis; Wong, Y T; Iliescu, C

    2008-01-01T23:59:59.000Z

    This paper presents the fabrication process, characterization results and basic functionality of silicon microneedles array with biodegradable tips. In order to avoid the main problems related to silicon microneedles : broking of the top part of the needles inside the skin, a simple solution can be fabrication of microneedles array with biodegradable tips. The silicon microneedles array was fabricated by using reactive ion etching while the biodegradable tips were performed using and anodization process that generates selectively porous silicon only on the top part of the skin. The paper presents also the results of in vitro release of calcein using microneedles array with biodegradable tips

  14. Local drug delivery for treatment of brain tumor associated edema

    E-Print Network [OSTI]

    Ong, Qunya

    2014-01-01T23:59:59.000Z

    Brain tumor associated edema, a common feature of malignant brain neoplasms, is a significant cause of morbidity from brain tumor. Systemic administration of corticosteroids, the standard of care, is highly effective but ...

  15. SMART DRUG DELIVERY AND BIONANOTECHNOLOGY Nicholas A Peppas

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    , micropatterned devices, systems for biological recognition, have shown the versatility of these biopolymeric

  16. Functionalization of nanocarriers for efficient combination drug delivery

    E-Print Network [OSTI]

    Hu, Che-Ming Jack

    2011-01-01T23:59:59.000Z

    proton resonance peaks of DOX-PLA (upper panel)and CPT-PLA (lower panel) Fig.cores consisting of: (A) DOX-PLA conjugates, (B) CPT-PLA

  17. Molecule Nanoweaver Improves Drug Delivery and Treatment Efficacy - Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment SurfacesResource ProgramModification andinterface of water.

  18. Artificial Cells for Advanced Drug Delivery - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout theOFFICEAmesApplication2Argonne National4

  19. Protein-Based Nanomedicine Platforms for Drug Delivery. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 - SeptemberMicroneedlesAdvanced Photon Source The Superpowerrelated

  20. Apoferritin-based nanomedicine platform for drug delivery: equilibrium

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone by E-mailRadioimmunotherapy of Cancers. | EMSLbinding study

  1. Targeting atherosclerosis : nanoparticle delivery for diagnosis and treatment

    E-Print Network [OSTI]

    Peters, David Thomas

    2009-01-01T23:59:59.000Z

    interventions for stenosis, or an abnormal narrowing of an artery due to atherosclerotic plaques, include percutaneous transluminal coronary

  2. Capital Projects Delivery Procedures Manual

    E-Print Network [OSTI]

    Alpay, S. Pamir

    1 Capital Projects Delivery Procedures Manual September 4, 2008 Office of the CFO #12;2 Page I of the Capital Budget 11 B. Budget Approval 12 C. Setting Up Capital Projects 13 III. Procedures for Design ­ Office of the Chief Financial Officer Financial Policies and Procedures for the Capital Project Delivery

  3. Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating

    E-Print Network [OSTI]

    Schmidt, Daniel J.

    Electrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a pharmacy-on-a-chip). Here we report the fabrication ...

  4. Secondary fuel delivery system

    DOE Patents [OSTI]

    Parker, David M. (Oviedo, FL); Cai, Weidong (Oviedo, FL); Garan, Daniel W. (Orlando, FL); Harris, Arthur J. (Orlando, FL)

    2010-02-23T23:59:59.000Z

    A secondary fuel delivery system for delivering a secondary stream of fuel and/or diluent to a secondary combustion zone located in the transition piece of a combustion engine, downstream of the engine primary combustion region is disclosed. The system includes a manifold formed integral to, and surrounding a portion of, the transition piece, a manifold inlet port, and a collection of injection nozzles. A flowsleeve augments fuel/diluent flow velocity and improves the system cooling effectiveness. Passive cooling elements, including effusion cooling holes located within the transition boundary and thermal-stress-dissipating gaps that resist thermal stress accumulation, provide supplemental heat dissipation in key areas. The system delivers a secondary fuel/diluent mixture to a secondary combustion zone located along the length of the transition piece, while reducing the impact of elevated vibration levels found within the transition piece and avoiding the heat dissipation difficulties often associated with traditional vibration reduction methods.

  5. Delivery of neuroactive peptide drugs to the brain via intranasal delivery

    E-Print Network [OSTI]

    Cros, C. D.; Toth, I.; Blanchfield, J.

    2006-10-27T23:59:59.000Z

    was sampled, placed on ice, and 75?L acetonitrile added to precipitate the plasma proteins. Samples were analysed by HPLC. Leu-Enkephalin analogues The peptides were synthesised by solid phase peptide synthesis with MBHA rink amide resin following Fmoc...

  6. Hydrogen Production and Delivery Research

    SciTech Connect (OSTI)

    Iouri Balachov, PhD

    2007-10-15T23:59:59.000Z

    In response to DOE's Solicitation for Grant Applications DE-PS36-03GO93007, 'Hydrogen Production and Delivery Research', SRI International (SRI) proposed to conduct work under Technical Topic Area 5, Advanced Electrolysis Systems; Sub-Topic 5B, High-Temperature Steam Electrolysis. We proposed to develop a prototype of a modular industrial system for low-cost generation of H{sub 2} (<$2/kg) by steam electrolysis with anodic depolarization by CO. Water will be decomposed electrochemically into H{sub 2} and O{sub 2} on the cathode side of a high-temperature electrolyzer. Oxygen ions will migrate through an oxygen-ion-conductive solid oxide electrolyte. Gas mixtures on the cathode side (H{sub 2} + H{sub 2}O) and on the anode side (CO + CO{sub 2}) will be reliably separated by the solid electrolyte. Depolarization of the anodic process will decrease the electrolysis voltage, and thus the electricity required for H{sub 2} generation and the cost of produced H{sub 2}. The process is expected to be at least 10 times more energy-efficient than low-temperature electrolysis and will generate H{sub 2} at a cost of approximately $1-$1.5/kg. The operating economics of the system can be made even more attractive by deploying it at locations where waste heat is available; using waste heat would reduce the electricity required for heating the system. Two critical targets must be achieved: an H{sub 2} production cost below $2/kg, and scalable design of the pilot H{sub 2} generation system. The project deliverables would be (1) a pilot electrolysis system for H{sub 2} generation, (2) an economic analysis, (3) a market analysis, and (4) recommendations and technical documentation for field deployment. DOE was able to provide only 200K out of 1.8M (or about 10% of awarded budget), so project was stopped abruptly.

  7. Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    32 Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION The Office of Electricity Delivery and Energy Reliability (OE) leads national efforts to modernize the electric...

  8. Final Report - Hydrogen Delivery Infrastructure Options Analysis...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    - Hydrogen Delivery Infrastructure Options Analysis Final Report - Hydrogen Delivery Infrastructure Options Analysis This report, by the Nexant team, documents an in-depth analysis...

  9. Final Report - Hydrogen Delivery Infrastructure Options Analysis

    Broader source: Energy.gov (indexed) [DOE]

    pipelines for gaseous hydrogen delivery Option 2: Use of existing natural gas or oil pipelines for gaseous hydrogen delivery Option 3: Use of existing natural gas pipelines...

  10. Methodology for the production and delivery of generative music for the personal listener : systems for realtime generative music production

    E-Print Network [OSTI]

    Murphy, Michael J.

    2013-11-27T23:59:59.000Z

    This thesis will describe a system for the production of generative music through specific methodology, and provide an approach for the delivery of this material. The system and body of work will be targeted specifically ...

  11. Nonviral Vectors for Gene Delivery

    E-Print Network [OSTI]

    Baoum, Abdulgader Ahmed

    2011-04-26T23:59:59.000Z

    optimized for gene delivery by varying particle surface chemistry using different coating materials that adsorb to the particle surface during formation. A variety of cationic coating materials were studied and compared to more conventional surfactants used...

  12. Best antibiotics for buccal delivery

    E-Print Network [OSTI]

    Goldberg, Manijeh Nazari

    2011-01-01T23:59:59.000Z

    The purpose of the research was to identify the clinical and commercial benefits of switching from intravenous (IV) to buccal delivery of antibiotics. then, the research continued to select 3-5 antibiotics that best met ...

  13. Variable delivery, fixed displacement pump

    DOE Patents [OSTI]

    Sommars, Mark F. (Sparland, IL)

    2001-01-01T23:59:59.000Z

    A variable delivery, fixed displacement pump comprises a plurality of pistons reciprocated within corresponding cylinders in a cylinder block. The pistons are reciprocated by rotation of a fixed angle swash plate connected to the pistons. The pistons and cylinders cooperate to define a plurality of fluid compression chambers each have a delivery outlet. A vent port is provided from each fluid compression chamber to vent fluid therefrom during at least a portion of the reciprocal stroke of the piston. Each piston and cylinder combination cooperates to close the associated vent port during another portion of the reciprocal stroke so that fluid is then pumped through the associated delivery outlet. The delivery rate of the pump is varied by adjusting the axial position of the swash plate relative to the cylinder block, which varies the duration of the piston stroke during which the vent port is closed.

  14. Hydrogen Distribution and Delivery Infrastructure

    Fuel Cell Technologies Publication and Product Library (EERE)

    This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

  15. Hydrogen Delivery Infrastructure Options Analysis

    Fuel Cell Technologies Publication and Product Library (EERE)

    This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

  16. Hydrogen Delivery Technology Roadmap, November 2005

    Fuel Cell Technologies Publication and Product Library (EERE)

    Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

  17. Radiation delivery system and method

    DOE Patents [OSTI]

    Sorensen, Scott A. (Overland Park, KS); Robison, Thomas W. (Los Alamos, NM); Taylor, Craig M. V. (Jemez Springs, NM)

    2002-01-01T23:59:59.000Z

    A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

  18. ?[subscript v]?[subscript 3] Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug

    E-Print Network [OSTI]

    Graf, Nora

    Targeted delivery of therapeutics to tumor neovasculature is potentially a powerful approach for selective cancer treatment. Integrins are heterodimeric transmembrane proteins involved in cell adhesion and cell signaling, ...

  19. Benchmark Problem: A PK/PD Model and Safety Constraints for Anesthesia Delivery

    E-Print Network [OSTI]

    Mitchell, Ian

    Benchmark Problem: A PK/PD Model and Safety Constraints for Anesthesia Delivery Victor Gan, Guy A of the goals of general anesthesia. In this brief paper we provide a differential equation model of how Introduction General anesthesia is a broad term encompassing the use of drugs to induce and maintain three

  20. Agenda for the Hydrogen Delivery and Onboard Storage Analysis...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage...

  1. Accelerator target

    DOE Patents [OSTI]

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29T23:59:59.000Z

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  2. Accelerator target

    DOE Patents [OSTI]

    Schlyer, David J. (Bellport, NY); Ferrieri, Richard A. (Patchogue, NY); Koehler, Conrad (Miller Place, NY)

    1999-01-01T23:59:59.000Z

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  3. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  4. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  5. Strategic Directions for Hydrogen Delivery Workshop Proceedings

    Broader source: Energy.gov [DOE]

    Proceedings from the Strategic Directions for Hydrogen Delivery Workshop held May 7-8, 2003 in Washington, DC. Author: Energetics

  6. Delivery and Hedging Delivery ties the futures price to the spot price.

    E-Print Network [OSTI]

    Lyuu, Yuh-Dauh

    Delivery and Hedging · Delivery ties the futures price to the spot price. · On the delivery date, the settlement price of the futures contract is determined by the spot price. · Hence, when the delivery period is reached, the futures price should be very close to the spot price. · Changes in futures prices usually

  7. E-Print Network 3.0 - anticancer drug cisplatin Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on mitochondrial oxygen consumption Abdul-Kader Souida... June 2003 Abstract The evolving role of mitochondria as a target for many anticancer drugs (e... DNA platination by...

  8. ORIGINAL PAPER Specificity and success of oral-bait delivery to Eurasian wild

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ORIGINAL PAPER Specificity and success of oral-bait delivery to Eurasian wild boar in Mediterranean December 2010 /Published online: 21 December 2010 # Springer-Verlag 2010 Abstract Eurasian wild boar (Sus of this study was to determine the proportion of young and adult wild boar and non-target animals that consumed

  9. Identifying novel drug indications through automated reasoning Authors and Affiliations

    E-Print Network [OSTI]

    Baral, Chitta

    of these drugs have potential anti-cancer activities based on information on their targets and molecular discovery, text mining, automated reasoning Abstract Background With the large amount of pharmacological interaction types alone. A total of 507 drugs were found to have the potential to be used for cancer

  10. Fiber coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO)

    2008-08-12T23:59:59.000Z

    A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

  11. Sandia National Laboratories: Hydrogen Delivery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -theErik Spoerke SSLS Exhibit atVehicle Technologies On November 9, 2010,Delivery

  12. Hydrogen Delivery Infrastructure Analysis, Options and Trade...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Analysis, Options and Trade-offs, Transition and Long-term Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long-term Presentation on Hydrogen...

  13. Gaseous Hydrogen Delivery Breakout - Strategic Directions for...

    Broader source: Energy.gov (indexed) [DOE]

    System Issues: need to assess delivery options in context of total system Materials: corrosion, H2 permeability Construction: welding, joining Maintenance and Operation: leak...

  14. Categorical Exclusion Determinations: Office of Electricity Delivery...

    Broader source: Energy.gov (indexed) [DOE]

    Electricity Delivery and Energy Reliability. DOCUMENTS AVAILABLE FOR DOWNLOAD September 18, 2012 CX-009236: Categorical Exclusion Determination Dynasty Power, Inc. Export...

  15. MFRC Training Development & Delivery Program - Bloodstain & Toxicology...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Resource Center (MFRC) Training Development and Delivery Program increases access to forensic science training for publicly funded state and local forensic scientists. Its goals...

  16. DOI: 10.1002/cmdc.200800122 HER-2-Targeted NanoparticleAffibody Bioconjugates for Cancer Therapy

    E-Print Network [OSTI]

    Zhang, Liangfang

    shown that this class of molecule can se- lectively bind to HER-2-overexpressing cell lines (SKBR-3 drug toxicity, and maintaining a relatively high concentration of drug at the site of interest.[1 drugs to diseased cells. The first examples of targeted NPs were reported in 1980, and despite nearly

  17. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 22 | Next | Last Back to Index NIF Target Chamber The interior of the NIF target chamber. The service module carrying technicians can be seen on the left. The target...

  18. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 22 | Next | Last Back to Index NIF Target Chamber A service system lift allows technicians to access the target chamber interior for inspection and maintenance. Photo Number:...

  19. Pharmacokinetics, or "How a drug reaches its target"

    E-Print Network [OSTI]

    Gugat, Martin

    15 20 25 30 35 40 45 Time (days) Concentration(mg·L-1) InL Michaelis-Menten(L) Cld CP, VcCt, Vt koff ke(RL) InL L = Ligand R = receptor RL = Receptor-Ligand complex ke(L) Parameter fit for data set 2 The dynamics is given by the system of nonlinear differential equations: dL dt = InL - konL · R + koff

  20. Gastric H,K-ATPase as a drug target

    E-Print Network [OSTI]

    Shin, Jai M; Sachs, G

    2006-01-01T23:59:59.000Z

    Review article: Helicobacter pylori and gastro- oesophagealWL: The treatment of Helicobacter pylori infection in thewith infection by Helicobacter pylori and the realization

  1. A Key Target for Diabetes Drugs | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered‰PNGExperience hands-onASTROPHYSICSHe β-Research andA Hollow-IonHybridA

  2. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2

  3. Structural genomics of infectious disease drug targets: the SSGCID. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administrationcontroller systemsBiSiteNeutronStrategicOur Mission Oura metalloproteinof infectious

  4. Gastric H,K-ATPase as a drug target

    E-Print Network [OSTI]

    Shin, Jai M; Sachs, G

    2006-01-01T23:59:59.000Z

    cations. J Biol Chem Fukushima Y, Nakao M: Changes inChem 1980;255(16):7813-9. Fukushima Y, Post RL: Binding of

  5. Tissue-Specific Gene Delivery via Nanoparticle Coating

    E-Print Network [OSTI]

    Harris, Todd J.

    The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

  6. Fiber laser coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

    2008-03-04T23:59:59.000Z

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  7. Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Permeability and Integrity of Hydrogen Delivery Pipelines Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines Project Objectives: To gain basic understanding of...

  8. Career Opportunities with the Office of Electricity Delivery...

    Broader source: Energy.gov (indexed) [DOE]

    Career Opportunities with the Office of Electricity Delivery & Energy Reliability (OE) Career Opportunities with the Office of Electricity Delivery & Energy Reliability (OE) Career...

  9. Comments of Cisco Systems to Office of Electricity Delivery and...

    Broader source: Energy.gov (indexed) [DOE]

    of Cisco Systems to Office of Electricity Delivery and Energy Reliability Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Cisco Systems provides...

  10. 2012 Annual Planning Summary for Electricity Delivery and Energy...

    Broader source: Energy.gov (indexed) [DOE]

    Electricity Delivery and Energy Reliability 2012 Annual Planning Summary for Electricity Delivery and Energy Reliability The ongoing and projected Environmental Assessments and...

  11. 2013 Annual Planning Summary for the Office of Electricity Delivery...

    Broader source: Energy.gov (indexed) [DOE]

    Electricity Delivery and Energy Reliability 2013 Annual Planning Summary for the Office of Electricity Delivery and Energy Reliability The ongoing and projected Environmental...

  12. Vacancy Announcements Posted for Hydrogen Production and Delivery...

    Broader source: Energy.gov (indexed) [DOE]

    Vacancy Announcements Posted for Hydrogen Production and Delivery Program Vacancy Announcements Posted for Hydrogen Production and Delivery Program October 3, 2014 - 10:49am...

  13. Special Delivery for Sustainability: Clean Cities Supports UPS...

    Broader source: Energy.gov (indexed) [DOE]

    Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding Natural Gas Operations Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding...

  14. accurate sobp delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 19 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  15. antiretroviral treatment delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

  16. avtip delivery order: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 25 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  17. adaptive aerosol delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 45 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  18. aerial dispersant delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 72 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  19. adenoviral gene delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

  20. arthritis boron delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 58 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  1. Office of Electricity Delivery and Energy Reliability Recovery...

    Broader source: Energy.gov (indexed) [DOE]

    Electricity Delivery and Energy Reliability Recovery Program Plan Office of Electricity Delivery and Energy Reliability Recovery Program Plan Microsoft Word - OE PSRP June 5 2009...

  2. Secretary of Energy Announces New Office of Electricity Delivery...

    Office of Environmental Management (EM)

    New Office of Electricity Delivery & Energy Reliability Secretary of Energy Announces New Office of Electricity Delivery & Energy Reliability June 9, 2005 - 1:45pm Addthis...

  3. Office of Electricity Delivery And Energy Reliability To Hold...

    Broader source: Energy.gov (indexed) [DOE]

    Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy...

  4. The Office of Electricity Delivery and Energy Reliability is...

    Broader source: Energy.gov (indexed) [DOE]

    The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) The Office of Electricity Delivery and Energy Reliability is Closely...

  5. Office of Electricity Delivery & Energy Reliability FY 2012 Budget...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation...

  6. Office of Electricity Delivery and Energy Reliability Cyber Security...

    Broader source: Energy.gov (indexed) [DOE]

    Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections On...

  7. Energy-Efficient Melting and Direct Delivery of High Quality...

    Broader source: Energy.gov (indexed) [DOE]

    Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum itmdelivery.pdf More...

  8. Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM...

    Broader source: Energy.gov (indexed) [DOE]

    Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results This presentation by...

  9. April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure...

    Energy Savers [EERE]

    April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure Initiative FOA April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure Initiative FOA March 23,...

  10. Status and EAC Recommendations for Electricity Delivery Workforce...

    Energy Savers [EERE]

    Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) This memo,...

  11. Hydrogen Delivery R&D Activities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    R&D Activities Hydrogen Delivery R&D Activities Hydrogen delivery technology may encompass several options over the short and long terms. The transportation and distribution...

  12. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and...

  13. First SNS Target Replacement

    E-Print Network [OSTI]

    McDonald, Kirk

    First SNS Target Replacement Experience M. Dayton, M. Rennich, Van Graves, J. DeVore Presented by T.S. Department of Energy AHIP Workshop Oct. 2009 Overview · Initial Target Replacement · Target Maintenance-Battelle for the U.S. Department of Energy AHIP Workshop Oct. 2009 First SNS Target Replacement · Replacement

  14. MECO Production Target Developments

    E-Print Network [OSTI]

    McDonald, Kirk

    be reoptimized Tungsten target Simulations of design parameters with GEANT3 indicate that both production targetMECO Production Target Developments James L. Popp University of California, Irvine NuFact'03 Columbia, June, 2003 #12;June, 2003J.L.Popp, UCI MECO Production Target 2 MECO Collaboration Institute

  15. Magnetically directed poly(lactic acid) [sup 90]Y-microspheres: Novel agents for targeted intracavitary radiotherapy

    SciTech Connect (OSTI)

    Haefeli, U.O.; Sweeney, S.M.; Beresford, B.A.; Sim, E.H.; Macklis, R.M. (Harvard Medical School, Boston, MA (United States). Joint Center for Radiation Therapy)

    1994-08-01T23:59:59.000Z

    High energy [beta]-emitting radioisotopes like Yttrium-90 have a radiotoxic range of about one centimeter. For cancer treatment they must be brought near the tumor cells and kept there for as long as they are radioactive. The authors developed as carriers for the ionic form of [sup 90]Y a matrix-type polymeric drug delivery system, poly(lactic acid) (PLA) microspheres. This radiopharmaceutical could be selectively delivered to the target site after incorporating 10% Fe[sub 3]O[sub 4] which made the magnetic microspheres (MMS) responsive to an external magnetic field. Furthermore, MMS are biodegradable and slowly hydrolyze into physiologic lactic acid after the radioactivity is completely decayed. Previously prepared 10--40 [mu]m MMS were radiochemically loaded to high specific activity with [sup 90]Y at a pH of 5.7. Stability studies showed that approximately 95% of added [sup 90]Y is retained within the PLA matrix after 28 days (> 10 half-lives) at 37 C in serum, and electron microscopy showed that the microspheres retained their characteristic morphologic appearance for the same time period. Cytotoxicity studies with SK-N-SH neuroblastoma cells growing in monolayer showed that the radiocytotoxicity of the microspheres could be directed magnetically to either kill or spare specific cell populations, thus making them of great interest for targeted intracavitary tumor therapy. The authors are currently optimizing this system for use in the treatment of neoplastic meningitis.

  16. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, Roy J. (Downers Grove, IL)

    1986-01-01T23:59:59.000Z

    A polarized internal target apparatus with a polarized gas target of improved polarization and density achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms.

  17. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, R.J.

    1984-10-10T23:59:59.000Z

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  18. Fuel Cell Technologies Office Multi-Year Research, Development, and Demonstration Plan- Section 3.2 Hydrogen Delivery

    Broader source: Energy.gov [DOE]

    Hydrogen Delivery technical plan section of the Fuel Cell Technologies Office Multi-Year Research, Development, and Demonstration Plan; updated October 2014. This plan includes goals, objectives, technical targets, tasks, and schedules for the Office of Energy Efficiency and Renewable Energy's contribution to the DOE Hydrogen and Fuel Cells Program.

  19. Composite gelatin delivery system for bone regeneration

    E-Print Network [OSTI]

    Hager, Elizabeth A. (Elizabeth Ann)

    2005-01-01T23:59:59.000Z

    In this thesis, the chemical/mechanical properties and biocompatibility of gelatin were investigated to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery ...

  20. Essays on health care delivery and financing

    E-Print Network [OSTI]

    Chan, David C. (David Cchimin)

    2013-01-01T23:59:59.000Z

    This thesis contains essays on health care delivery and financing. Chapter 1 studies the effect of organizational structure on physician behavior. I investigate this by studying emergency department (ED) physicians who ...

  1. Coordinated part delivery using distributed planning

    E-Print Network [OSTI]

    Bolger, Adrienne (Adrienne M.)

    2010-01-01T23:59:59.000Z

    In this thesis, we develop a distributed mobile robot platform to deliver parts around a model construction site. The platform's robots, specialized into delivery robots and assembly robots, use a distributed coverage ...

  2. Delivery and Receipt | Department of Energy

    Energy Savers [EERE]

    (301) 903-3790; Phone: (301) 903-6492 Delivery Addresses for the Loading Docks U.S. Department of Energy Forrestal Building 1000 Independence Avenue, S.W. Washington, D.C. 20585...

  3. Magnetically attached sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1994-02-15T23:59:59.000Z

    An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

  4. TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)

    SciTech Connect (OSTI)

    Dunne, A M

    2010-11-30T23:59:59.000Z

    The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition scheme is an essential component of an acceptably low-risk solution. The degree of coupling seen on NIF between driver and target performance mandates that little deviation be adopted from the NIF geometry and beamline characteristics. Similarly, the strong coupling between subsystems in an operational power plant mandates that a self-consistent solution be established via an integrated facility delivery project. The benefits of separability of the subsystems within an IFE plant (driver, chamber, targets, etc.) emerge in the operational phase of a power plant rather than in its developmental phase. An optimized roadmap for IFE delivery needs to account for this to avoid nugatory effort and inconsistent solutions. For LIFE, a system design has been established that could lead to an operating power plant by the mid-2020s, drawing from an integrated subsystem development program to demonstrate the required technology readiness on a time scale compatible with the construction plan. Much technical development work still remains, as does alignment of key stakeholder groups to this newly emerging development option. If the required timeline is to be met, then preparation of a viable program is required alongside the demonstration of ignition on NIF. This will enable timely analysis of the technical and economic case and establishment of the appropriate delivery partnership.

  5. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 22 | Next | Last Back to Index NIF Target A NIF target contains a polished capsule about two millimeters in diameter, filled with cryogenic (super-cooled) hydrogen fuel. Photo...

  6. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5 22 | Next | Last Back to Index NIF Target Chamber This view from the bottom of the chamber shows the target positioner being inserted. Pulses from NIF's high-powered lasers...

  7. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9 22 | Next | Last Back to Index NIF Hohlraum A metallic case called a hohlraum holds the fuel capsule for NIF experiments. Target handling systems precisely position the target...

  8. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 22 | Next | Last Back to Index NIF Target Chamber Temperatures of 100 million degrees and pressures extreme enough to compress the target to densities up to 100 times the...

  9. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to Index Target Chamber Viewing Window A new viewing window recently installed on the NIF Target Chamber will allow members of the NIF team and visitors to see inside the...

  10. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01T23:59:59.000Z

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  11. A study of IMRT planning parameters on planning efficiency, delivery efficiency, and plan quality

    SciTech Connect (OSTI)

    Mittauer, Kathryn [Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, Florida 32603 and J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 (United States); Lu Bo; Yan Guanghua; Kahler, Darren; Amdur, Robert; Liu Chihray [Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, Florida 32603 (United States); Gopal, Arun [Department of Radiation Oncology, New York-Presbyterian Hospital, Columbia University, New York, New York 10032 (United States)

    2013-06-15T23:59:59.000Z

    Purpose: To improve planning and delivery efficiency of head and neck IMRT without compromising planning quality through the evaluation of inverse planning parameters.Methods: Eleven head and neck patients with pre-existing IMRT treatment plans were selected for this retrospective study. The Pinnacle treatment planning system (TPS) was used to compute new treatment plans for each patient by varying the individual or the combined parameters of dose/fluence grid resolution, minimum MU per segment, and minimum segment area. Forty-five plans per patient were generated with the following variations: 4 dose/fluence grid resolution plans, 12 minimum segment area plans, 9 minimum MU plans, and 20 combined minimum segment area/minimum MU plans. Each plan was evaluated and compared to others based on dose volume histograms (DVHs) (i.e., plan quality), planning time, and delivery time. To evaluate delivery efficiency, a model was developed that estimated the delivery time of a treatment plan, and validated through measurements on an Elekta Synergy linear accelerator. Results: The uncertainty (i.e., variation) of the dose-volume index due to dose calculation grid variation was as high as 8.2% (5.5 Gy in absolute dose) for planning target volumes (PTVs) and 13.3% (2.1 Gy in absolute dose) for planning at risk volumes (PRVs). Comparison results of dose distributions indicated that smaller volumes were more susceptible to uncertainties. The grid resolution of a 4 mm dose grid with a 2 mm fluence grid was recommended, since it can reduce the final dose calculation time by 63% compared to the accepted standard (2 mm dose grid with a 2 mm fluence grid resolution) while maintaining a similar level of dose-volume index variation. Threshold values that maintained adequate plan quality (DVH results of the PTVs and PRVs remained satisfied for their dose objectives) were 5 cm{sup 2} for minimum segment area and 5 MU for minimum MU. As the minimum MU parameter was increased, the number of segments and delivery time were decreased. Increasing the minimum segment area parameter decreased the plan MU, but had less of an effect on the number of segments and delivery time. Our delivery time model predicted delivery time to within 1.8%. Conclusions: Increasing the dose grid while maintaining a small fluence grid allows for improved planning efficiency without compromising plan quality. Delivery efficiency can be improved by increasing the minimum MU, but not the minimum segment area. However, increasing the respective minimum MU and/or the minimum segment area to any value greater than 5 MU and 5 cm{sup 2} is not recommended because it degrades plan quality.

  12. Main chain acid-degradable polymers for the delivery of bioactive materials

    DOE Patents [OSTI]

    Frechet, Jean M. J. (Oakland, CA); Standley, Stephany M. (Evanston, IL); Jain, Rachna (Milpitas, CA); Lee, Cameron C. (Cambridge, MA)

    2012-03-20T23:59:59.000Z

    Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.

  13. Monte Carlo calculation of helical tomotherapy dose delivery

    SciTech Connect (OSTI)

    Zhao Yingli; Mackenzie, M.; Kirkby, C.; Fallone, B. G. [Department of Medical Physics, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada) and Department of Physics, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada); Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada); Department of Medical Physics, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada and Department of Physics, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2 (Canada)

    2008-08-15T23:59:59.000Z

    Helical tomotherapy delivers intensity modulated radiation therapy using a binary multileaf collimator (MLC) to modulate a fan beam of radiation. This delivery occurs while the linac gantry and treatment couch are both in constant motion, so the beam describes, from a patient/phantom perspective, a spiral or helix of dose. The planning system models this continuous delivery as a large number (51) of discrete gantry positions per rotation, and given the small jaw/fan width setting typically used (1 or 2.5 cm) and the number of overlapping rotations used to cover the target (pitch often <0.5), the treatment planning system (TPS) potentially employs a very large number of static beam directions and leaf opening configurations to model the modulated fields. All dose calculations performed by the system employ a convolution/superposition model. In this work the authors perform a full Monte Carlo (MC) dose calculation of tomotherapy deliveries to phantom computed tomography (CT) data sets to verify the TPS calculations. All MC calculations are performed with the EGSnrc-based MC simulation codes, BEAMnrc and DOSXYZnrc. Simulations are performed by taking the sinogram (leaf opening versus time) of the treatment plan and decomposing it into 51 different projections per rotation, as does the TPS, each of which is segmented further into multiple MLC opening configurations, each with different weights that correspond to leaf opening times. Then the projection is simulated by the summing of all of the opening configurations, and the overall rotational treatment is simulated by the summing of all of the projection simulations. Commissioning of the source model was verified by comparing measured and simulated values for the percent depth dose and beam profiles shapes for various jaw settings. The accuracy of the MLC leaf width and tongue and groove spacing were verified by comparing measured and simulated values for the MLC leakage and a picket fence pattern. The validated source and MLC configuration were then used to simulate a complex modulated delivery from fixed gantry angle. Further, a preliminary rotational treatment plan to a delivery quality assurance phantom (the 'cheese' phantom) CT data set was simulated. Simulations were compared with measured results taken with an A1SL ionization chamber or EDR2 film measurements in a water tank or in a solid water phantom, respectively. The source and MLC MC simulations agree with the film measurements, with an acceptable number of pixels passing the 2%/1 mm gamma criterion. 99.8% of voxels of the MC calculation in the planning target volume (PTV) of the preliminary plan passed the 2%/2 mm gamma value test. 87.0% and 66.2% of the voxels in two organs at risk (OARs) passed the 2%/2 mm tests. For a 3%/3 mm criterion, the PTV and OARs show 100%, 93.2%, and 86.6% agreement, respectively. All voxels passed the gamma value test with a criterion of 5%/3 mm. The TomoTherapy TPS showed comparable results.

  14. The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier

    E-Print Network [OSTI]

    Wang, Jing

    2008-01-01T23:59:59.000Z

    It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is ...

  15. Renewable energy delivery systems and methods

    DOE Patents [OSTI]

    Walker, Howard Andrew

    2013-12-10T23:59:59.000Z

    A system, method and/or apparatus for the delivery of energy at a site, at least a portion of the energy being delivered by at least one or more of a plurality of renewable energy technologies, the system and method including calculating the load required by the site for the period; calculating the amount of renewable energy for the period, including obtaining a capacity and a percentage of the period for the renewable energy to be delivered; comparing the total load to the renewable energy available; and, implementing one or both of additional and alternative renewable energy sources for delivery of energy to the site.

  16. A systems approach to uncovering the adaptive response of cancer to targeted therapies

    E-Print Network [OSTI]

    Randall, Adrian Joseph

    2012-01-01T23:59:59.000Z

    Tyrosine kinase inhibitors have significant promise in the fight to develop agents that can target cancer in a tumor-specific manner. A number of drugs have been and are currently in development to inhibit specific kinases ...

  17. Non-traditional platinum compounds for improved cellular accumulation and tumor targeting

    E-Print Network [OSTI]

    Lovejoy, Katherine Summer, 1981-

    2009-01-01T23:59:59.000Z

    Chapter 1. Introduction to Non-Traditional Platinum Compounds for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration ...

  18. Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners

    E-Print Network [OSTI]

    Hanzlik, Robert P.; Fang, Jianwen; Koen, Yakov M.

    2009-06-12T23:59:59.000Z

    Background Protein covalent binding by reactive metabolites of drugs, chemicals and natural products can lead to acute cytotoxicity. Recent rapid progress in reactive metabolite target protein identification has shown ...

  19. Crucial stages of protein folding through a solvable model: Predicting target sites

    E-Print Network [OSTI]

    Cecconi, Fabio

    Crucial stages of protein folding through a solvable model: Predicting target sites for enzyme. Keywords: Protein-folding modeling; prediction of key folding sites; HIV-1 protease; drug resistance One

  20. Target Cost Management Strategy

    E-Print Network [OSTI]

    Okano, Hiroshi

    1996-01-01T23:59:59.000Z

    Target cost management (TCM) is an innovation of Japanese management accounting system and by common sense has been considered with great interest by practitioners. Nowadays, TCM related

  1. Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy

    SciTech Connect (OSTI)

    Diot, Quentin; Kavanagh, Brian; Timmerman, Robert; Miften, Moyed [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States); Department of Radiation Oncology, University of Texas Southwestern Medical School, Dallas, Texas 75390 (United States); Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States)

    2012-01-15T23:59:59.000Z

    Purpose: To describe biological-based optimization and Monte Carlo (MC) dose calculation-based treatment planning for volumetric modulated arc therapy (VMAT) delivery of stereotactic body radiation therapy (SBRT) in lung, liver, and prostate patients. Methods: Optimization strategies and VMAT planning parameters using a biological-based optimization MC planning system were analyzed for 24 SBRT patients. Patients received a median dose of 45 Gy [range, 34-54 Gy] for lung tumors in 1-5 fxs and a median dose of 52 Gy [range, 48-60 Gy] for liver tumors in 3-6 fxs. Prostate patients received a fractional dose of 10 Gy in 5 fxs. Biological-cost functions were used for plan optimization, and its dosimetric quality was evaluated using the conformity index (CI), the conformation number (CN), the ratio of the volume receiving 50% of the prescription dose over the planning target volume (Rx/PTV50). The quality and efficiency of the delivery were assessed according to measured quality assurance (QA) passing rates and delivery times. For each disease site, one patient was replanned using physical cost function and compared to the corresponding biological plan. Results: Median CI, CN, and Rx/PTV50 for all 24 patients were 1.13 (1.02-1.28), 0.79 (0.70-0.88), and 5.3 (3.1-10.8), respectively. The median delivery rate for all patients was 410 MU/min with a maximum possible rate of 480 MU/min (85%). Median QA passing rate was 96.7%, and it did not significantly vary with the tumor site. Conclusions: VMAT delivery of SBRT plans optimized using biological-motivated cost-functions result in highly conformal dose distributions. Plans offer shorter treatment-time benefits and provide efficient dose delivery without compromising the plan conformity for tumors in the prostate, lung, and liver, thereby improving patient comfort and clinical throughput. The short delivery times minimize the risk of patient setup and intrafraction motion errors often associated with long SBRT treatment delivery times.

  2. Smart drug discovery leveraging innovative technologies and predictive knowledge

    E-Print Network [OSTI]

    Cai, Long

    the risk of failure. Owing to the integration of key in silico and experimental tools. A positive aspect of this paradigm shift includes faster,strategic decision making with respect to drug targets from the human genome pro- vides opportunities for detailed analysis of structure and function

  3. Liquid Hydrogen Delivery - Strategic Directions for Hydrogen...

    Broader source: Energy.gov (indexed) [DOE]

    2005 Target: 1.01kg Technically (10% improvement) could be met, but unlikely demand drivers will be present to encourage meeting target Likely no plant will be built in 2005...

  4. DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project...

    Broader source: Energy.gov (indexed) [DOE]

    Delivery High-Pressure Tanks and Analysis Project Review Meeting DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting On February 8-9, 2005, the Department...

  5. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 Cooling Channel in both walls for draining · Downstream end can be shortened, assuming the window cooling is adequate #12;11 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 Remote Handling

  6. Tracking Mobile Units for Dependable Message Delivery

    E-Print Network [OSTI]

    Zhou, Yuanyuan

    Tracking Mobile Units for Dependable Message Delivery Amy L. Murphy, Member, IEEE Computer Society at their disposal at any time, mobile computing is developing as an important research area. One of the fundamental problems in mobility is maintaining connectivity through message passing as the user moves through

  7. Materials Solutions for Hydrogen Delivery in Pipelines

    E-Print Network [OSTI]

    Materials Solutions for Hydrogen Delivery in Pipelines Dr. Subodh K. Das Secat, Inc. September of new pipeline infrastructure Develop barrier coatings for minimizing hydrogen permeation in pipelines;NACE Hydrogen Induced Cracking (HIC) Test Evaluates resistance of pipeline and pressure vessel

  8. Improvements to Hydrogen Delivery Scenario Analysis

    E-Print Network [OSTI]

    Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad and storage are at or adjacent to Liquid Hydrogen (LH) TruckH2 Production 100 or 1500 kg/d Compressed H2 (CH) Truck H2 Production 3 or 7 kpsi 100 or 1500 kg/d H2 Production Gaseous H2 Pipeline 100 or 1500 kg

  9. Hg Delivery System Vacuum 25 Oct 2005

    E-Print Network [OSTI]

    McDonald, Kirk

    . S. DEPARTMENT OF ENERGY V. Graves 25 Oct 2005 MERIT Mtg at MIT Oct 17-19 · During Hg delivery system to both design and operations #12;3 OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY V. Graves 25 & return lines - Sump tank & all connecting ports - Hg cylinder & bellows Hg inlet Hg cylinder & Bellows

  10. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Broader source: Energy.gov (indexed) [DOE]

    Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry...

  11. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Broader source: Energy.gov (indexed) [DOE]

    Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia...

  12. Global delivery of IT services : looking beyond the global delivery model

    E-Print Network [OSTI]

    Cherian, Binoy

    2007-01-01T23:59:59.000Z

    The objective of this thesis is to analyze the factors that create competitive advantage through global delivery of IT services. Research on this thesis consists of a review of IT services markets and globally distributed ...

  13. FINAL AGENDA DOE Hydrogen Delivery Analysis and High Pressure Tanks

    E-Print Network [OSTI]

    , National Renewable Energy Laboratory 3:00 BREAK 3:15 H2A Delivery Scenario Model and Analyses Jerry:15 Ethanol Delivery Cost and Distributed Ethanol Reforming Matt Ringer, National Renewable Energy Laboratory and breakfast 8:30 Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long

  14. Turbomachine injection nozzle including a coolant delivery system

    DOE Patents [OSTI]

    Zuo, Baifang (Simpsonville, SC)

    2012-02-14T23:59:59.000Z

    An injection nozzle for a turbomachine includes a main body having a first end portion that extends to a second end portion defining an exterior wall having an outer surface. A plurality of fluid delivery tubes extend through the main body. Each of the plurality of fluid delivery tubes includes a first fluid inlet for receiving a first fluid, a second fluid inlet for receiving a second fluid and an outlet. The injection nozzle further includes a coolant delivery system arranged within the main body. The coolant delivery system guides a coolant along at least one of a portion of the exterior wall and around the plurality of fluid delivery tubes.

  15. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 22 | Next | Last Back to Index NIF Hohlraum This artist's rendering shows a NIF target pellet inside a hohlraum capsule with laser beams entering through openings on either...

  16. In the Target Area

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 22 | Next | Last Back to Index NIF Target Chamber On March 10, 2009, at 3:15 a.m., a 192-beam laser shot delivered 1.1 million joules of ultraviolet light to the center of the...

  17. SNS Target Systems Operational

    E-Print Network [OSTI]

    McDonald, Kirk

    a failed gas seal on the shaft and leaking oil seals but has operated well since then · The moderator 7.5 k First target replacement · No observed corrosion · Internal Boroscope examination in progress · ~ 50 mm

  18. A Lorentz-force actuated controllable needle-free drug delivery system

    E-Print Network [OSTI]

    Hemond, Brian D. (Brian David Thomson)

    2004-01-01T23:59:59.000Z

    The advantages of delivering injections via needle-free methods are numerous. However, conventional methods for needle-free injection lack sufficient control over depth of penetration and shape of injection. Thus, a ...

  19. Fabrication of Metal/Oxide Nanostructures by Anodization Processes for Biosensor, Drug Delivery and Supercapacitor Applications

    E-Print Network [OSTI]

    Chen, Po-Chun

    2014-01-13T23:59:59.000Z

    applications of micro/nano structures; (2) novel processes to innovate anodic aluminum oxide nanotube template; (3) the supercapacitor applications of anodic titanium oxide. First, the extremely high surface area AAO coated microneedle and microneedle array...

  20. Nanostructured gene and drug delivery systems based on molecular self-assembly

    E-Print Network [OSTI]

    Wood, Kris Cameron

    2007-01-01T23:59:59.000Z

    Molecular self-assembly describes the assembly of molecular components into complex, supramolecular structures governed by weak, non-covalent interactions. In recent years, molecular self-assembly has been used extensively ...

  1. Bioactive and bioresponsive nanoparticle surface modifications for vaccine and systemic drug delivery

    E-Print Network [OSTI]

    Clawson, Corbin Zean

    2011-01-01T23:59:59.000Z

    stealth coatings have been developed to function in similar ways to PEG by preventing recognition of the foreign material

  2. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01T23:59:59.000Z

    Staphylococcus aureus (MRSA) growth in chronic otitis mediaco-glycolide) disc: Inhibition of MRSA(methicillin resistantco-glycolide) disc: Inhibition of MRSA(methicillin resistant

  3. Evaluation & design of a novel drug delivery device for treating tumor-related cerebral edema

    E-Print Network [OSTI]

    Shair, Kamal A. (Kamal Abdo)

    2010-01-01T23:59:59.000Z

    Tumor-related cerebral edema is a debilitating medical condition that afflicts tens of thousands of newly diagnosed brain cancer patients in the U.S. each year, where the standard care of treatment indicates the systemic ...

  4. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01T23:59:59.000Z

    Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureMichael J. Engineering the chemistry and nanostructure of

  5. Chemically modified and nanostructured porous silicon as a drug delivery material and device

    E-Print Network [OSTI]

    Anglin, Emily Jessica

    2007-01-01T23:59:59.000Z

    Sailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructureSailor, M. J. , Engineering the chemistry and nanostructure

  6. Design, synthesis, and evaluation of dendrimers based on melamine as drug delivery vehicles

    E-Print Network [OSTI]

    Lim, Jong Doo

    2009-05-15T23:59:59.000Z

    .1 Divergent and convergent synthetic routes to dendrimers .......................... 2 1.2 Architecture of dendrimers: (a) PPI; (b) PAMAM; (c) polyester; (d) triazine-based dendrimer... 3.9 Post-PET biodistribution data of a 124 I-labeled dendrimer (~17 kDa) in nude mice with PC-3-Luc xenografts at 48 h post-injection .................. 41 4.1 1 H NMR assignment and integration of 2 in the expanded region 4.8 to 8.2 ppm...

  7. Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery

    E-Print Network [OSTI]

    Bagby, Taryn Rochelle

    2011-12-31T23:59:59.000Z

    Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ...

  8. Lymphocyte-mediated drug nanoparticle delivery to disseminated lymphoma tumors in vivo

    E-Print Network [OSTI]

    Huang, Bonnie

    2013-01-01T23:59:59.000Z

    The dissemination of lymphoma into anatomical compartments that are poorly accessible from circulation, such as lymph nodes, necessitates high doses of systemic chemotherapy. However, the potencies of many chemotherapeutic ...

  9. Refactored M13 Bacteriophage as a Platform for Tumor Cell Imaging and Drug Delivery

    E-Print Network [OSTI]

    Ghosh, Debadyuti

    M13 bacteriophage is a well-characterized platform for peptide display. The utility of the M13 display platform is derived from the ability to encode phage protein fusions with display peptides at the genomic level. However, ...

  10. Functionalized Zirconium Phosphate Nano Platelets - From Surface Design to Drug Delivery

    E-Print Network [OSTI]

    Mukherjee, Atashi

    2014-05-30T23:59:59.000Z

    spectrometry (SIMS) technique are Au_(400)^(4+) and C_(60)^(+/2+). The ionized ejecta from each impact are recorded individually which identifies ions emitted from a surface volume of ~10 nm in diameter and 5-10 nm in depth. The mode of analyzing ejecta...

  11. Theoretical and experimental investigations of passive and ultrasound-enhanced transdermal drug delivery

    E-Print Network [OSTI]

    Kushner, Joseph, IV

    2007-01-01T23:59:59.000Z

    In the initial investigation of this thesis, Fick's second law of diffusion was modified to describe both the transient, and the steady-state, transdermal transport of hydrophilic permeants through unbranched, aqueous pore ...

  12. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

    DOE Patents [OSTI]

    Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

    2014-07-22T23:59:59.000Z

    Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

  13. Development of lymphatic drug delivery platforms for the treatment of carcinomas

    E-Print Network [OSTI]

    Cai, Shuang

    2011-05-31T23:59:59.000Z

    .234 2. Release of nitric oxide from JS-K, JS-K analogues and carrier-based prodrugs.....236 xi 3. Dosing schedule and results of caspase-3, resazurin and trypan blue assays in MDA-1986 cells.......238 4. Results.... In the following chapters, the development, characterization, in vitro and in vivo evaluation, of three polymer-based chemotherapeutic conjugates will be described. 2. Localized chemotherapy The most common types of cancer therapies include surgery, radiation...

  14. Synthesis of novel polymeric nanoparticles for hydrophobic and hydrophilic drug delivery

    E-Print Network [OSTI]

    Sartor, Marta

    2010-01-01T23:59:59.000Z

    at 30?C. The mobile phase water to acetonitrile ratio 50:70 water to acetonitrile was kept constant during thestandards were in the same acetonitrile percent solution.

  15. pH-sensitive core-shell nanoparticles for intracellular drug delivery

    E-Print Network [OSTI]

    Hu, Yuhua, Ph. D. Massachusetts Institute of Technology

    2008-01-01T23:59:59.000Z

    Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis ...

  16. Nano compartments may aid drug delivery, catalyst design > Archived News

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the Contributions andData andFleet TestAccounts andThe Role ofStorage - Energy

  17. E-Print Network 3.0 - adhesive drug delivery Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    calls for the design of the ... Source: Peppas, Nicholas A. - Departments of Biomedical Engineering & Chemical Engineering, University of Texas at Austin Collection:...

  18. AVTA: Hybrid-Electric Delivery Vehicles

    Broader source: Energy.gov [DOE]

    The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a wide range of advanced vehicles and technologies on dynamometers, closed test tracks, and on-the-road. These results provide benchmark data that researchers can use to develop technology models and guide future research and development. The following set of reports describes data collected from testing on FedEx Express and UPS hybrid-electric delivery trucks. This research was conducted by the National Renewable Energy Laboratory (NREL).

  19. Waste Feed Delivery Transfer System Analysis

    SciTech Connect (OSTI)

    JULYK, L.J.

    2000-05-05T23:59:59.000Z

    This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms.

  20. Delivery Tech Team | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeat Pump Models | Department1 Prepared1217 Release Notes Dekker PMISWashmgton,Delivery

  1. Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer

    E-Print Network [OSTI]

    Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

    2011-05-28T23:59:59.000Z

    Abstract Background The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This can only be achieved if the drug used is against a specific target...

  2. Waste feed delivery planning at Hanford

    SciTech Connect (OSTI)

    Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

    2013-01-10T23:59:59.000Z

    The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

  3. Waste Feed Delivery Planning at Hanford - 13232

    SciTech Connect (OSTI)

    Certa, Paul J.; Hohl, Ted M.; Kelly, James W.; Larsen, Douglas C.; West, Elizha B.; Ritari, Jaakob S.; Rodriguez, Juissepp S. [Washington River Protection Solutions, LLC, P.O. 850, Richland, WA 99352 (United States)] [Washington River Protection Solutions, LLC, P.O. 850, Richland, WA 99352 (United States)

    2013-07-01T23:59:59.000Z

    The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades. (authors)

  4. Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting

    E-Print Network [OSTI]

    Cheng, Jianjun

    /parallel synthesis that creates a large library of materials and allows identification of the best. Gabrielson, Hua Lu, Jianjun Cheng* Department of Materials Science and Engineering, University of Illinois of the gene cargos, it meanwhile causes severe associated cytotoxicities [7e9]. Excessive positive charges can

  5. Development of alternating amphiphilic copolymers for targeted delivery applications in cancer

    E-Print Network [OSTI]

    Brower, Kevin P. (Kevin Peter)

    2011-01-01T23:59:59.000Z

    According to the American Cancer Society, approximately 1,479,000 new cases of cancer were expected to be diagnosed, while 562,340 Americans were expected to die from cancer in 2009 alone. Even though advances in early ...

  6. Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinement plasmasSandy-Nor'easter SituationHybridVehicles

  7. Realizing Technologies for Magnetized Target Fusion

    SciTech Connect (OSTI)

    Wurden, Glen A. [Los Alamos National Laboratory

    2012-08-24T23:59:59.000Z

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  8. Foam encapsulated targets

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

    1983-01-01T23:59:59.000Z

    Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

  9. Target | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia:FAQ < RAPID Jump to:Seadov Pty LtdSteen,Ltd Jump to:Taos County, New Mexico: EnergyTarget GmbH Jump to:Target

  10. USE OF DRUG ELUTING STENTS AS A FUNCTION OF PREDICTED BENEFIT: CLINICAL AND ECONOMIC IMPLICATIONS OF CURRENT PRACTICE

    E-Print Network [OSTI]

    Amin, Amit P.

    2011-12-31T23:59:59.000Z

    Background: Benefits of drug-eluting stents (DES) in percutaneous coronary intervention (PCI) are greatest in those at the highest risk of target vessel revascularization (TVR). While DES reduce restenosis, they cost more than bare metal stents (BMS...

  11. Targeted radionuclide therapy

    SciTech Connect (OSTI)

    Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

    2008-07-15T23:59:59.000Z

    Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

  12. Future Fixed Target Facilities

    SciTech Connect (OSTI)

    Melnitchouk, Wolodymyr

    2009-01-01T23:59:59.000Z

    We review plans for future fixed target lepton- and hadron-scattering facilities, including the 12 GeV upgraded CEBAF accelerator at Jefferson Lab, neutrino beam facilities at Fermilab, and the antiproton PANDA facility at FAIR. We also briefly review recent theoretical developments which will aid in the interpretation of the data expected from these facilities.

  13. ISAC target vacuum system

    SciTech Connect (OSTI)

    Yosifov, Dimo; Sekachev, Igor [TRIUMF, Canada's National Laboratory for Particle and Nuclear Physics, Vancouver, British Columbia V6T 2A3 (Canada)

    2006-07-15T23:59:59.000Z

    The Isotope Separator and Accelerator (ISAC) facility at TRIUMF has been in full operation since 1999. The ISAC east and west targets use proton beam from the cyclotron to produce various radioactive isotopes, which are then ionized and extracted. The ions are then passed through the mass separator and selected ions are transferred to the low energy experiments or injected into a radio frequency quadrupole accelerator. The accompanying radioactive contamination from the production of radioactive ions requires a complex vacuum system. The main target vacuum space consists of two semiseparate (primary and secondary) volumes pumped by turbo-molecular pumps. The primary volume uses four pumps while the secondary volume uses two pumps. Two hermetic rotary vane pumps are used as backing pumps. The nominal vacuum in both volumes is about 1.33x10{sup -4} Pa (1.0x10{sup -6} Torr). The pressure is monitored by two cold cathode and two hot filament ion gauges. The cold cathode gauges are used to interlock the system, which is critical during the bake out of the target and beam production. The exhaust gas from the vacuum pumps can be radioactive. Three gas storage tanks (decay tanks) are used for temporary storage of the radioactive exhaust and its controlled release to the atmosphere. Gas-species insensitive membrane gauges are used for monitoring the pressure in the storage tanks. This article describes the details of the ISAC target vacuum system as well as some procedures related to the handling of the exhaust gas with traces of radioactive contamination produced by the targets.

  14. Delivery and Receipt | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energy UsageAUDITVehicles » AlternativeUp HomeHorseDOE DirectivesDepartment of2Delivery and

  15. Solid Target Options S. Childress

    E-Print Network [OSTI]

    McDonald, Kirk

    power is higher than for existing solid target designs - but not by a large factor. · NuMI graphite beam power) · High beam power solid targets frequently use higher z materials for increased yield plusSolid Target Options NuFACT'00 S. Childress Solid Target Options · The choice of a primary beam

  16. ,"New Mexico Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,,"(202) 586-8800",,,"3292015 10:05:26 PM" "Back to Contents","Data 1: New Mexico Natural Gas Deliveries to Electric Power Consumers (MMcf)"...

  17. 2012 Director's Science Delivery Award | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SHARE 2012 Director's Science Delivery Award June 24, 2013 CSMD Researcher Forrest Hoffman (along with ORNL researchers Jitendra Kumar and Richard Mills), is on the team that...

  18. PHEV Parcel Delivery Truck Model - Development and Preliminary Results (Presentation)

    SciTech Connect (OSTI)

    Barnitt, R

    2009-10-28T23:59:59.000Z

    Describes results of a study to determine the impact of drive cycles on the energy- and cost-effectiveness of plug-in hybrid electric delivery vans.

  19. Vectren Energy Delivery of Indiana (Gas)- Residential Energy Efficiency Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers its residential natural gas customers in Indiana rebates for the installation of certain high efficiency natural gas appliances and insulation measures. Rebates are...

  20. Vectren Energy Delivery of Ohio (Gas)- Residential Energy Efficiency Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers residential natural gas customers in Ohio rebates for the installation of certain high efficiency natural gas appliances and building insulation. Rebates are...

  1. Determining the lowest-cost hydrogen delivery mode

    E-Print Network [OSTI]

    Yang, Christopher; Ogden, Joan M

    2007-01-01T23:59:59.000Z

    costs to estimate hydrogen pipeline costs. Davis, CA: ITS-hydrogen. The cost of hydrogen pipeline delivery de- pendshydrogen trucks, and hydrogen pipelines, were devel- oped

  2. Office of Electricity Delivery and Energy Reliability, OE-20

    Broader source: Energy.gov (indexed) [DOE]

    9 January, 2012 Office of Electricity Delivery and Energy Reliability, OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 Greetings: The Wyoming...

  3. Vectren Energy Delivery of Indiana (Gas)- Commercial Energy Efficiency Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers commercial natural gas customers in Indiana rebates for the installation of certain types of efficient natural gas equipment. Prescriptive equipment rebates are...

  4. Office of Electricity Delivery and Energy Reliability | Department...

    Broader source: Energy.gov (indexed) [DOE]

    & Internships Funding Opportunities Information Center Contact Us Energy.gov Office of Electricity Delivery & Energy Reliability 1000 Independence Avenue, SW Washington, DC...

  5. Vectren Energy Delivery of Ohio (Gas)- Commercial Energy Efficiency Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers commercial natural gas customers in Ohio rebates for the installation of certain types of efficient natural gas equipment. Prescriptive equipment rebates are...

  6. H2A Delivery Components Model and Analysis

    Broader source: Energy.gov (indexed) [DOE]

    Hydrogen Delivery Components Model Matt Ringer National Renewable Energy Laboratory February 8, 2005 Other Team Members: Mark Paster: DOE Marianne Mintz, Jerry Gillette, Jay Burke:...

  7. H2A Delivery Scenario Model and Analyses

    Broader source: Energy.gov (indexed) [DOE]

    Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office...

  8. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Broader source: Energy.gov (indexed) [DOE]

    Practice DesignConfiguration Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practice DesignConfiguration National lab researchers, industry...

  9. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Broader source: Energy.gov (indexed) [DOE]

    Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the...

  10. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Broader source: Energy.gov (indexed) [DOE]

    Visualization and Modeling Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and...

  11. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Broader source: Energy.gov (indexed) [DOE]

    PracticesStandards Development Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best PracticesStandards Development National lab researchers, industry...

  12. Hydrogen Delivery Technologies and Systems- Pipeline Transmission of Hydrogen

    Broader source: Energy.gov [DOE]

    Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen. Design and operations standards and materials for hydrogen and natural gas pipelines.

  13. Liquid Hydrogen Production and Delivery from a Dedicated Wind...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    a Dedicated Wind Power Plant Liquid Hydrogen Production and Delivery from a Dedicated Wind Power Plant This May 2012 study assesses the costs and potential for remote renewable...

  14. Hydrogen Delivery InfrastructureHydrogen Delivery Infrastructure Option AnalysisOption Analysis

    E-Print Network [OSTI]

    Converting NG/oil pipelines for GH delivery Option 3 Blending GH into NG pipelines Option 4* GH tube trailers Option 5* LH tank trucks Option 6 Use of novel H2 carriers (alanate; chemical hydride; liquid hydrocarbon as CA) -- NG distribution lines: gas companies usually use for Class 3 & 4 No odorants used in current H

  15. Cost comparison of collaborative and IPD-like project delivery methods versus non-collaborative project delivery methods

    E-Print Network [OSTI]

    Kulkarni, Aditi; Rybkowski, Zofia K.; Smith, James

    2012-07-17T23:59:59.000Z

    Proceedings of the 20th Conference of the International Group for Lean Construction July 17-22, 2012: San Diego, CA, U.S.A. 781 COST COMPARISON OF COLLABORATIVE AND IPD-LIKE PROJECT DELIVERY METHODS VERSUS COMPETITIVE NON... acceptance of IPD for public projects. KEYWORDS Collaboration, Project Delivery, CM-at-Risk (CMR; CMAR), Competitive Sealed Proposal (CSP), Integrated Project Delivery (IPD), Design-Bid-Build (DBB), Cost Comparison INTRODUCTION One of the most widely...

  16. Targeting Cancer More Effectively CR@B brings together researchers from across the University and the Royal United Hospital, Bath.

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Targeting Cancer More Effectively CR@B brings together researchers from across the University to find a cure for various types of cancer. 40 academic groups from nearly every department to bedside and back again. Drug Discovery The discovery of a new family of anti-cancer drugs called steroid

  17. A planning and delivery study of a rotational IMRT technique with burst delivery

    SciTech Connect (OSTI)

    Kainz, Kristofer; Chen, Guang-Pei; Chang, Yu-Wen; Prah, Douglas; Sharon Qi, X.; Shukla, Himanshu P.; Stahl, Johannes; Allen Li, X. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States); Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado 80045 (United States); Siemens Oncology Care Systems, Concord, California 94520 (United States); Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States)

    2011-09-15T23:59:59.000Z

    Purpose: A novel rotational IMRT (rIMRT) technique using burst delivery (continuous gantry rotation with beam off during MLC repositioning) is investigated. The authors evaluate the plan quality and delivery efficiency and accuracy of this dynamic technique with a conventional flat 6 MV photon beam. Methods: Burst-delivery rIMRT was implemented in a planning system and delivered with a 160-MLC linac. Ten rIMRT plans were generated for five anonymized patient cases encompassing head and neck, brain, prostate, and prone breast. All plans were analyzed retrospectively and not used for treatment. Among the varied plan parameters were the number of optimization points, number of arcs, gantry speed, and gantry angle range (alpha) over which the beam is turned on at each optimization point. Combined rotational/step-and-shoot rIMRT plans were also created by superimposing multiple-segment static fields at several optimization points. The rIMRT trial plans were compared with each other and with plans generated using helical tomotherapy and VMAT. Burst-mode rotational IMRT plans were delivered and verified using a diode array, ionization chambers, thermoluminescent dosimeters, and film. Results: Burst-mode rIMRT can achieve plan quality comparable to helical tomotherapy, while the former may lead to slightly better OAR sparing for certain cases and the latter generally achieves slightly lower hot spots. Few instances were found in which increasing the number of optimization points above 36, or superimposing step-and-shoot IMRT segments, led to statistically significant improvements in OAR sparing. Using an additional rIMRT partial arc yielded substantial OAR dose improvements for the brain case. Measured doses from the rIMRT plan delivery were within 4% of the plan calculation in low dose gradient regions. Delivery time range was 228-375 s for single-arc rIMRT 200-cGy prescription with a 300 MU/min dose rate, comparable to tomotherapy and VMAT. Conclusions: Rotational IMRT with burst delivery, whether combined with static fields or not, yields clinically acceptable and deliverable treatment plans.

  18. Timely Delivery of Laser Inertial Fusion Energy Presentation prepared for

    E-Print Network [OSTI]

    plant design · Delivery soon enough to make a difference to global energy imperatives. · Design basedTimely Delivery of Laser Inertial Fusion Energy Presentation prepared for Town Hall meeting must directly address the end-user requirement for commercial power 3 Plant Primary Criteria (partial

  19. CIB White Paper on IDDS Integrated Design & Delivery Solutions

    E-Print Network [OSTI]

    Amor, Robert

    CIB White Paper on IDDS Integrated Design & Delivery Solutions Publication 328 ISBN 978-90-6363-060-7 #12;CIB White Paper on IDDS Page 1 of 15 CIB White Paper on IDDS Integrated Design & Delivery White Paper on IDDS Page 2 of 15 Table of Contents Introduction and Use of this White Paper

  20. Optical diagnostics integrated with laser spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

    2008-09-02T23:59:59.000Z

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  1. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest Region service area. TheEPSCI HomeTours, Programs and2 This flight2 Target 2

  2. Advanced Target Effects Modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth (AOD)ProductssondeadjustsondeadjustAbout the BuildingInnovation PortalScience of SignaturesAdvanced Target

  3. 4? Non-Coplanar Liver SBRT: A Novel Delivery Technique

    SciTech Connect (OSTI)

    Dong, Peng; Lee, Percy; Ruan, Dan [Department of Radiation Oncology, University of California, Los Angeles, California (United States)] [Department of Radiation Oncology, University of California, Los Angeles, California (United States); Long, Troy; Romeijn, Edwin [Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor, Michigan (United States); Yang, Yingli; Low, Daniel; Kupelian, Patrick [Department of Radiation Oncology, University of California, Los Angeles, California (United States)] [Department of Radiation Oncology, University of California, Los Angeles, California (United States); Sheng, Ke, E-mail: ksheng@mednet.ucla.edu [Department of Radiation Oncology, University of California, Los Angeles, California (United States)] [Department of Radiation Oncology, University of California, Los Angeles, California (United States)

    2013-04-01T23:59:59.000Z

    Purpose: To improve the quality of liver stereotactic body radiation therapy (SBRT) treatments, a novel 4? framework was developed with accompanying algorithms to optimize non-coplanar beam orientations and fluences. The dose optimization is performed on a patient-specific deliverable beam geometry solution space, parameterized with patient and linear accelerator gantry orientations. Methods and Materials: Beams causing collision between the gantry and the couch or patient were eliminated by simulating all beam orientations using a precise computer assisted design model of the linear accelerator and a human subject. Integrated beam orientation and fluence map optimizations were performed on remaining beams using a greedy column generation method. Testing of the new method was performed on 10 liver SBRT cases previously treated with 50 to 60 Gy in 5 fractions using volumetric modulated arc therapy (VMAT). For each patient, both 14 and 22 non-coplanar fields were selected and optimized to meet the objective of ?95% of the planning target volume (PTV) covered by 100% of the prescription dose. Doses to organs at risk, normal liver volumes receiving <15 Gy, integral dose, and 50% dose spillage volumes were compared against the delivered clinical VMAT plans. Results: Compared with the VMAT plans, the 4? plans yielded reduced 50% dose spillage volume and integral dose by 22% (range 10%-40%) and 19% (range 13%-26%), respectively. The mean normal liver volume receiving <15 Gy was increased by 51 cc (range 21-107 cc) with a 31% reduction of the mean normal liver dose. Mean doses to the left kidney and right kidney and maximum doses to the stomach and spinal cord were on average reduced by 70%, 51%, 67%, and 64% (P?.05). Conclusions: This novel 4? non-coplanar radiation delivery technique significantly improved dose gradient, reduced high dose spillage, and improved organ at risk sparing compared with state of the art VMAT plans.

  4. Joint Meeting on Hydrogen Delivery Modeling and Analysis FreedomCAR and Fuels Partnership Hydrogen Delivery, Storage and

    E-Print Network [OSTI]

    . ­ The current capital costs for the hydrogen pipelines in the model are based on 1.1X the price of steel naturalJoint Meeting on Hydrogen Delivery Modeling and Analysis FreedomCAR and Fuels Partnership Hydrogen be prioritized) by mid-2008 H2A Delivery Model: Discussion Items, Comments, and Follow-up Actions 1. Pipeline

  5. The University of New Mexico An NSF Integrative Graduate

    E-Print Network [OSTI]

    New Mexico, University of

    in INCBN IGERT Seminar Location: Room 101, Center for High Technology Materials (CHTM) 1313 Goddard SE SW drug delivery methods (including passive targeting of "stealth" nanoparticles and receptor

  6. Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen

    Broader source: Energy.gov [DOE]

    Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen.Solid and liquid hydrogen carriers for use in hydrogen storage and delivery.

  7. U.S. Department of Energy Office of Electricity Delivery & Energy...

    Broader source: Energy.gov (indexed) [DOE]

    Department of Energy Office of Electricity Delivery & Energy Reliability: Transmission Reliability Program U.S. Department of Energy Office of Electricity Delivery & Energy...

  8. anti-hiv sirna delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

  9. aav-mediated intramuscular delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 24 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  10. E-Print Network 3.0 - advocates expanded delivery Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    POLICY AND MANAGEMENT JULY 14, 2010 Summary: DELIVERY SYSTEM REDESIGN The US health care delivery system is expensive, fragmented, highly decentralized... , efficient, and...

  11. 2H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...

    Broader source: Energy.gov (indexed) [DOE]

    pipelines for gaseous hydrogen delivery Option 2: Use of existing natural gas or oil pipelines for gaseous hydrogen delivery Option 3: Use of existing natural gas pipelines...

  12. Rotating Target Development for SNS Second Target Station

    SciTech Connect (OSTI)

    McManamy, Thomas J [ORNL; Rennich, Mark J [ORNL; Crawford, Roy K [ORNL; Geoghegan, Patrick J [ORNL; Janney, Jim G [ORNL

    2010-01-01T23:59:59.000Z

    A rotating target for the second target station (STS) at SNS has been identified as an option along with a mercury target. Evaluation of the rotating target alternative for STS has started at 1.5 MW which is considered an upper bound for the power. Previous preconceptual design work for a 3 MW rotating target is being modified for the lower power level. Transient thermal analysis for a total loss of active water cooling has been done for a simplified 2D model of the target and shielding monolith which shows that peak temperatures are well below the level at which tungsten vaporization by steam could exceed site boundary dose limits. Design analysis and integration configuration studies have been done for the target-moderator-reflector assembly which maximizes the number of neutron beam lines and provides for replacement of the target and moderators. Target building hot cell arrangement for this option will be described. An option for operation in rough vacuum without a proton beam window using Ferro fluid seals on a vertical shaft is being developed. A full scale prototypic drive module based on the 3 MW preconceptual design has been fabricated and successfully tested with a shaft and mock up target supplied by the ESS-Bilbao team. Overall planning leading to decision between mercury and the rotating target in 2011 will be discussed

  13. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, David J. (Fremont, CA); Anex, Deon S. (Livermore, CA); Yan, Chao (Pleasanton, CA); Dadoo, Rajeev (Stanford, CA); Zare, Richard N. (Stanford, CA)

    1999-01-01T23:59:59.000Z

    Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

  14. PDFs for nuclear targets

    E-Print Network [OSTI]

    Karol Kovarik

    2010-06-25T23:59:59.000Z

    Understanding nuclear effects in parton distribution functions (PDF) is an essential component needed to determine the strange and anti-strange quark contributions in the proton. In addition Nuclear Parton Distribution Functions (NPDF) are critically important for any collider experiment with nuclei (e.g. RHIC, ALICE). Here two next-to-leading order chi^2-analyses of NPDF are presented. The first uses neutral current charged-lepton Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DIS data. We compare the nuclear corrections factors (F_2^Fe/F_2^D) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.

  15. ORION laser target diagnostics

    SciTech Connect (OSTI)

    Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K. [Plasma Physics Department, Atomic Weapons Establishment, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); and others

    2012-10-15T23:59:59.000Z

    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  16. Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu

    E-Print Network [OSTI]

    Vemula, Praveen Kumar

    Targeted delivery of drugs and sensors into cells is an attractive technology with both medical and scientific applications. Existing delivery vehicles are generally limited by the complexity of their design, dependence ...

  17. Bounding Radionuclide Inventory and Accident Consequence Calculation for the 1L Target

    SciTech Connect (OSTI)

    Kelsey, Charles T. IV [Los Alamos National Laboratory

    2011-01-01T23:59:59.000Z

    A bounding radionuclide inventory for the tungsten of the Los Alamos Neutron Science Center (LANSCE) IL Target is calculated. Based on the bounding inventory, the dose resulting from the maximum credible incident (MCI) is calculated for the maximally exposed offsite individual (MEOl). The design basis accident involves tungsten target oxidation following a loss of cooling accident. Also calculated for the bounding radionuclide inventory is the ratio to the LANSCE inventory threshold for purposes of inventory control as described in the target inventory control policy. A bounding radionuclide inventory calculation for the lL Target was completed using the MCNPX and CINDER'90 codes. Continuous beam delivery at 200 {micro}A to 2500 mA{center_dot}h was assumed. The total calculated activity following this irradiation period is 205,000 Ci. The dose to the MEOI from the MCI is 213 mrem for the bounding inventory. The LANSCE inventory control threshold ratio is 132.

  18. Agenda for the Hydrogen Delivery and Onboard Storage Analysis...

    Broader source: Energy.gov (indexed) [DOE]

    - T. P. Chen, Nexant 2:45 pm Break 3:00 pm Hydrogen Delivery Demonstrations - Ed Kiczek, Air Products & Chemicals, Inc. 3:10 pm Pathway Cost Distributions: Fuel Pathway...

  19. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...

    Broader source: Energy.gov (indexed) [DOE]

    8:15 H2A Delivery Model Changes and Discussion: Matt Hooks (TIAX LLC), Bruce Kelly (Nexant), Jerry Gillette (ANL), Matt Ringer (NREL), Amgad Elgowainy (ANL) 8:15...

  20. ,"New York Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,,"(202) 586-8800",,,"182015 12:47:52 PM" "Back to Contents","Data 1: New York Natural Gas Deliveries to Electric Power Consumers (MMcf)" "Sourcekey","N3045NY2"...

  1. Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions

    E-Print Network [OSTI]

    Macdonald, Mara Lee

    2010-01-01T23:59:59.000Z

    This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer ...

  2. Design of an underwater vertical glider for subsea equipment delivery

    E-Print Network [OSTI]

    Ambler, Charles Kirby

    2010-01-01T23:59:59.000Z

    Delivery of subsea equipment and sensors is generally accomplished with unguided sinking platforms or powered autonomous underwater vehicles (AUVs). An alternative would be to augment existing platforms with navigation and ...

  3. Delivery optimization for a make to order custom wire mill

    E-Print Network [OSTI]

    Slivinskiy, Andrey L

    2005-01-01T23:59:59.000Z

    In the face of growing competition in the Tantalum business, H.C.Starck's management is minimizing the delivery time for custom-made capacitor-grade tantalum wire products. H.C. Starck, Inc., Newton, Massachusetts faces ...

  4. Hydrogen Delivery Technologies and Pipeline Transmission of Hydrogen

    E-Print Network [OSTI]

    Hydrogen Delivery Technologies and Systems Pipeline Transmission of Hydrogen Strategic Initiatives, and Infrastructure Technologies Program #12;Pipeline Transmission of Hydrogen --- 2 Copyright: Design & Operation development) #12;Pipeline Transmission of Hydrogen --- 3 Copyright: Future H2 Infrastructure Wind Powered

  5. Determining the Lowest-Cost Hydrogen Delivery Mode

    E-Print Network [OSTI]

    Yang, Christopher; Ogden, Joan M

    2008-01-01T23:59:59.000Z

    Costs to Estimate Hydrogen Pipeline Costs. 2004, ITS-Davis:hydrogen. The cost of hydrogen pipeline delivery depends onCosts to Estimate Hydrogen Pipeline Costs. 2004, ITS-Davis:

  6. Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

    E-Print Network [OSTI]

    Sharei, Armon Reza

    Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This technology has shown potential in addressing previously challenging ...

  7. A vector-free microfluidic platform for intracellular delivery

    E-Print Network [OSTI]

    Sharei, Armon Reza

    Intracellular delivery of macromolecules is a challenge in research and therapeutic applications. Existing vector-based and physical methods have limitations, including their reliance on exogenous materials or electrical ...

  8. Office of Electricity Delivery and Energy Reliability, OE-20

    Broader source: Energy.gov (indexed) [DOE]

    6, 2012 Office of Electricity Delivery and Energy Reliability, OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 RE: Comments for Consideration in...

  9. Lamont Jackson Office of Electricity Delivery and Energy Reliability

    Energy Savers [EERE]

    March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C....

  10. Mr. Lamont Jackson Office of Electricity Delivery and Energy...

    Energy Savers [EERE]

    March 28, 2012 Mr. Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585...

  11. Lamont Jackson Office of Electricity Delivery and Energy Reliability

    Energy Savers [EERE]

    March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585...

  12. Vacancy Announcements Posted for Hydrogen Production and Delivery Program

    Broader source: Energy.gov [DOE]

    The Fuel Cell Technologies Office has posted two vacancy announcements for a position to serve as Program Manager for the Hydrogen Production and Delivery Program in the DOE EERE Fuel Cell Technologies Office. The closing date is October 28, 2014.

  13. Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery (Presentation)

    SciTech Connect (OSTI)

    Jalalzadeh-Azar, A.

    2010-10-18T23:59:59.000Z

    This presentation summarizes "A Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery".

  14. Delivery system for molten salt oxidation of solid waste

    DOE Patents [OSTI]

    Brummond, William A. (Livermore, CA); Squire, Dwight V. (Livermore, CA); Robinson, Jeffrey A. (Manteca, CA); House, Palmer A. (Walnut Creek, CA)

    2002-01-01T23:59:59.000Z

    The present invention is a delivery system for safety injecting solid waste particles, including mixed wastes, into a molten salt bath for destruction by the process of molten salt oxidation. The delivery system includes a feeder system and an injector that allow the solid waste stream to be accurately metered, evenly dispersed in the oxidant gas, and maintained at a temperature below incineration temperature while entering the molten salt reactor.

  15. Providing ordered message delivery in communication network systems

    E-Print Network [OSTI]

    Rivera-Hernandez, Julio A

    1995-01-01T23:59:59.000Z

    PROVIDING ORDERED MESSAGE DELIVERY IN COMMUNICATION NETWORK SYSTEMS A Thesis by JULI0 A. RIVERA-HERNANDEZ Submitted to the Oflice of Graduate Studies of Texas AkM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1995 Major Subject: Computer Science PROVIDING ORDERED MESSAGE DELIVERY IN COMMUNICATION NETWORK SYSTEMS A Thesis by JULIO A. RIVERA-HERNANDEZ Submitted to Texas ARM University in partial fulfillment of the requirements for the degree...

  16. The OLYMPUS Internal Hydrogen Target

    E-Print Network [OSTI]

    J. C. Bernauer; V. Carassiti; G. Ciullo; B. S. Henderson; E. Ihloff; J. Kelsey; P. Lenisa; R. Milner; A. Schmidt; M. Statera

    2014-04-02T23:59:59.000Z

    An internal hydrogen target system was developed for the OLYMPUS experiment at DESY, in Hamburg, Germany. The target consisted of a long, thin-walled, tubular cell within an aluminum scattering chamber. Hydrogen entered at the center of the cell and exited through the ends, where it was removed from the beamline by a multistage pumping system. A cryogenic coldhead cooled the target cell to counteract heating from the beam and increase the density of hydrogen in the target. A fixed collimator protected the cell from synchrotron radiation and the beam halo. A series of wakefield suppressors reduced heating from beam wakefields. The target system was installed within the DORIS storage ring and was successfully operated during the course of the OLYMPUS experiment in 2012. Information on the design, fabrication, and performance of the target system is reported.

  17. Economic and Conservation Evaluation of Capital Renovation Projects: Harlingen Irrigation District Cameron County No. 1 Canal Meters and Telemetry Equipment, Impervious-Lining of Delivery Canals, Pipelines Replacing Delivery Canals, and On-Farm Delivery-Site Meters

    E-Print Network [OSTI]

    Rister, M. Edward; Lacewell, Ronald D.; Sturdivant, Allen W.; Robinson, John R.C.; Popp, Michael C.; Ellis, John R.

    , impervious-lining of delivery canals, 24" pipelines replacing delivery canals, and on-farm delivery-site meters). Sensitivity results for both the cost of water savings and cost of energy savings are presented for several important parameters. Expected cost...

  18. Photosensitizer Conjugates For Pathogen Targeting

    SciTech Connect (OSTI)

    Hasan, Tayyaba (Arlington, MA); Hamblin, Michael R. (Revere, MA); Soukos, Nikos (Revere, MA)

    2002-10-08T23:59:59.000Z

    Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.

  19. POLARIZED TARGET EXPERIMENT AT FERMILAB

    E-Print Network [OSTI]

    Chamberlain, O.

    2010-01-01T23:59:59.000Z

    on Experiment 61 at Fermilab, which is a large collaborationBernie Sandler, From From Fermilab. Alan Jonckheere andTARGET EXPERIMENT AT FERMILAB Owen Chamberlain January 1977

  20. Target Space Duality III: Potentials

    E-Print Network [OSTI]

    Orlando Alvarez; Blazej Ruszczycki

    2007-12-31T23:59:59.000Z

    We generalize previous results on target space duality to the case where there are background fields and the sigma model lagrangian has a potential function.

  1. Cost Comparison of Collaborative and IPD-like Project Delivery Methods Versus Competitive Non-collaborative Project Delivery Methods

    E-Print Network [OSTI]

    Kulkarni, Aditi

    2012-07-16T23:59:59.000Z

    Collaborative project delivery methods are believed to contribute to faster completions times, lower overall project costs and higher quality. Contracts are expected to influence the degree of collaboration on a given project since they allow...

  2. VERTEX CHAMBERS TARGET CELL CALORIMETER

    E-Print Network [OSTI]

    DRIFT VC 1/2 FC 1/2 VERTEX CHAMBERS TARGET CELL DVC MC 13 HODOSCOPE H0 MONITOR BC 1/2 BC 3/4 TRD at Threashold Lambda Physics (u L spin transfer) Motivation: W L Target cell e beam L p p e Elastic: Peltier elements ( T ~ 20C ) Custom built electronics + HELIX chips low autgassing (

  3. Polypharmacology Modelling Using Proteochemometrics (PCM): Recent Methodological Developments, Applications to Target Families, and Future Prospects

    E-Print Network [OSTI]

    Corts-Ciriano, Isidro; ul Ain, Qurrat; Subramanian, Vigneshwari; Lenselink, Eelke B.; Mndez-Lucio, Oscar; IJzerman, Adriaan P.; Wohlfahrt, Gerd; Prusis, Peteris; Malliavin, Thrse E.; van Westen, Gerard J. P.; Bender, Andreas

    2014-10-07T23:59:59.000Z

    to be in the order of $1.8 billion per drug. In addition, price pressure from health care providers has been increasing and there is a growing relevance of more targeted medicine. Hence, the blockbuster model of the pharmaceutical industry is being challenged.1...

  4. Id-1 and Id-2 genes and products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    DOE Patents [OSTI]

    Desprez, Pierre-Yves; Campisi, Judith

    2014-09-30T23:59:59.000Z

    A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.

  5. Winner of the 2014 $500,000 Lemelson-MIT Prize Dr. Sangeeta BhaCa Bha$a's combined clinical and engineering perspec$ve targets the development of miniaturized technologies to impact human

    E-Print Network [OSTI]

    Reif, Rafael

    $a and her trainees have launched ten companies with more than 70 products. She technologies to impact human health in areas ranging from drug toxicity, $ssue$on with probio$c vehicles to fine-tune dosing and delivery control. Methods to improve

  6. Tank Farms and Waste Feed Delivery - 12507

    SciTech Connect (OSTI)

    Fletcher, Thomas; Charboneau, Stacy; Olds, Erik [US DOE (United States)

    2012-07-01T23:59:59.000Z

    The mission of the Department of Energy's Office of River Protection (ORP) is to safely retrieve and treat the 56 million gallons of Hanford's tank waste and close the Tank Farms to protect the Columbia River. Our discussion of the Tank Farms and Waste Feed Delivery will cover progress made to date with Base and Recovery Act funding in reducing the risk posed by tank waste and in preparing for the initiation of waste treatment at Hanford. The millions of gallons of waste are a by-product of decades of plutonium production. After irradiated fuel rods were taken from the nuclear reactors to the processing facilities at Hanford they were exposed to a series of chemicals designed to dissolve away the rod, which enabled workers to retrieve the plutonium. Once those chemicals were exposed to the fuel rods they became radioactive and extremely hot. They also couldn't be used in this process more than once. Because the chemicals are caustic and extremely hazardous to humans and the environment, underground storage tanks were built to hold these chemicals until a more permanent solution could be found. The underground storage tanks range in capacity from 55,000 gallons to more than 1 million gallons. The tanks were constructed with carbon steel and reinforced concrete. There are eighteen groups of tanks, called 'tank farms', some having as few as two tanks and others up to sixteen tanks. Between 1943 and 1964, 149 single-shell tanks were built at Hanford in the 200 West and East Areas. Heat generated by the waste and the composition of the waste caused an estimated 67 of these single-shell tanks to leak into the ground. Washington River Protection Solutions is the prime contractor responsible for the safe management of this waste. WRPS' mission is to reduce the risk to the environment that is posed by the waste. All of the pumpable liquids have been removed from the single-shell tanks and transferred to the double-shell tanks. What remains in the single-shell tanks are solid and semi-solid wastes. Known as salt-cakes, they have the consistency of wet beach sand. Some of the waste resembles small broken ice, or whitish crystals. Because the original pumps inside the tanks were designed to remove only liquid waste, other methods have been developed to reach the remaining waste. Access to the tank waste is through long, typically skinny pipes, called risers, extending out of the tanks. It is through these pipes that crews are forced to send machines and devices into the tanks that are used to break up the waste or push it toward a pump. These pipes range in size from just a few inches to just over a foot in diameter because they were never intended to be used in this manner. As part of the agreement regulating Hanford cleanup, crews must remove at least 99% of the material in every tank on the site, or at least as much waste that can be removed based on available technology. To date, seven single-shell tanks have been emptied, and work is underway in another 10 tanks in preparation for additional retrieval activities. Two barriers have been installed over single-shell tanks to prevent the intrusion of surface water down to the tanks, with additional barriers planned for the future. Single and double-shell tank integrity analyses are ongoing. Because the volume of the waste generated through plutonium production exceeded the capacity of the single-shell tanks, between 1968 and 1986 Hanford engineers built 28 double-shell tanks. These tanks were studied and made with a second shell to surround the carbon steel and reinforced concrete. The double-shell tanks have not leaked any of their waste. (authors)

  7. antiepileptic drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  8. IPNS enriched uranium booster target

    SciTech Connect (OSTI)

    Schulke, A.W. Jr.

    1985-01-01T23:59:59.000Z

    Since startup in 1981, IPNS has operated on a fully depleted /sup 238/U target. With the booster as in the present system, high energy protons accelerated to 450 MeV by the Rapid Cycling Synchrotron are directed at the target and by mechanisms of spallation and fission of the uranium, produce fast neutrons. The neutrons from the target pass into adjacent moderator where they slow down to energies useful for spectroscopy. The target cooling systems and monitoring systems have operated very reliably and safely during this period. To provide higher neutron intensity, we have developed plans for an enriched uranium (booster) target. HETC-VIM calculations indicate that the target will produce approx.90 kW of heat, with a nominal x5 gain (k/sub eff/ = 0.80). The neutron beam intensity gain will be a factor of approx.3. Thermal-hydraulic and heat transport calculations indicate that approx.1/2 in. thick /sup 235/U discs are subject to about the same temperatures as the present /sup 238/U 1 in. thick discs. The coolant will be light demineralized water (H/sub 2/O) and the coolant flow rate must be doubled. The broadening of the fast neutron pulse width should not seriously affect the neutron scattering experiments. Delayed neutrons will appear at a level about 3% of the total (currently approx.0.5%). This may affect backgrounds in some experiments, so that we are assessing measures to control and correct for this (e.g., beam tube choppers). Safety analyses and neutronic calculations are nearing completion. Construction of the /sup 235/U discs at the ORNL Y-12 facility is scheduled to begin late 1985. The completion of the booster target and operation are scheduled for late 1986. No enriched uranium target assembly operating at the projected power level now exists in the world. This effort thus represents an important technological experiment as well as being a ''flux enhancer''.

  9. Process management applications in biopharmaceutical drug production

    E-Print Network [OSTI]

    Smith, Stephen E

    2011-01-01T23:59:59.000Z

    Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products ...

  10. Targets and methods for target preparation for radionuclide production

    DOE Patents [OSTI]

    Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

    2012-10-16T23:59:59.000Z

    The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

  11. Delivery of MicroR A-10b with Polylysine Nanoparticles for Inhibition...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delivery of MicroR A-10b with Polylysine Nanoparticles for Inhibition of Breast Cancer Cell Wound Healing. Delivery of MicroR A-10b with Polylysine Nanoparticles for Inhibition of...

  12. Using Integrated Project Delivery (IPD) to Resolve the Major Construction Project Delay Causes in Saudi Arabia

    E-Print Network [OSTI]

    Alkhalid, Khalid Abdullah

    2011-12-16T23:59:59.000Z

    Integrated Project Delivery (IPD) has gained attention in the United States and Europe as an effective delivery method for construction projects. The aim of this research paper is to determine the major causes of delay in ...

  13. Proton Delivery and Removal in [Ni(PR2NR?2)2]2+ Hydrogen...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delivery and Removal in Ni(PR2NR?2)22+ Hydrogen Production and Oxidation Catalysts. Proton Delivery and Removal in Ni(PR2NR?2)22+ Hydrogen Production and Oxidation...

  14. Understanding barriers to efficient nucleic acid delivery with bioresponsive block copolymers

    E-Print Network [OSTI]

    Bonner, Daniel Kenneth

    2012-01-01T23:59:59.000Z

    The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have been held back by immunogenicity and toxicity ...

  15. Apatite-Polymer Composite Particles for Controlled Delivery of BMP-2

    E-Print Network [OSTI]

    Yong, Tseh-Hwan

    We have developed a versatile delivery platform comprising a novel composite of two biomaterials with proven track records: apatite and poly(lactic-co-glycolic acid) (PLGA). These composites have been tested in the delivery ...

  16. Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor

    E-Print Network [OSTI]

    Arifin, Davis Yohanes

    This study presents the recent development of three-dimensional patient-specific simulation of carmustine delivery to brain tumor that highlights several crucial factors affecting the delivery. The simulation utilizes the ...

  17. Cell squeezing : a vector-free microfluidic platform for intracellular delivery of macromolecules

    E-Print Network [OSTI]

    Sharei, Armon R. (Armon Reza)

    2013-01-01T23:59:59.000Z

    Intracellular delivery of material is a long-standing challenge for both therapeutic and research applications. Existing technologies rely on a variety of mechanisms to facilitate delivery. Vector-based methods, such as ...

  18. Urban Sewage Delivery Heat Transfer System (2): Heat Transfer

    E-Print Network [OSTI]

    Zhang, C.; Wu, R.; Li, X.; Li, G.; Zhuang, Z.; Sun, D.

    2006-01-01T23:59:59.000Z

    The thimble delivery heat-transfer (TDHT) system is one of the primary modes to utilize the energy of urban sewage. Using the efficiency-number of transfer units method ( ), the heat-transfer efficiencies of the parallel-flow and reverse-flow TDTH...

  19. Project Management Business Process Project Delivery Processes Includes VE Budget

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Project Management Business Process Project Delivery Processes Includes VE Budget Schedule Activities that do/could feed into PMBP LEGEND VE Cost Avoidance Program Coverage Document Results (Before, could use the value methodology to facilitate after action review. The project manager is responsible

  20. Scalable Analysis, Verification and Design of IC Power Delivery

    E-Print Network [OSTI]

    Zeng, Zhiyu

    2012-02-14T23:59:59.000Z

    efficiency for large grids must be improved and the entire network with off-chip models and nonlinear devices should be able to be analyzed. Gated power delivery networks have multiple on/off operating conditions that need to be fully verified against...

  1. United Parcel Service Evaluates Hybrid Electric Delivery Vans (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2010-02-01T23:59:59.000Z

    This fact sheet describes how the National Renewable Energy Laboratory's Fleet Test and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans - fueled by regular diesel - and six comparable conventional diesel vans operated by the United Parcel Service.

  2. Lipophilic Peptides for Gene Delivery Carla A. H. Prata,

    E-Print Network [OSTI]

    University, Boston, Massachusetts 02215, Department of Biological and Environmental Engineering, Cornell laboratories and in ViVo gene delivery holds the promise for curing many diseases. The synthetic carriers of lipophilic peptides including the synthesis, physio- chemical properties, cytotoxicity, and in Vitro gene

  3. A Research Infrastructure for SOA-based Service Delivery Frameworks

    E-Print Network [OSTI]

    Wichmann, Felix

    -of-the-art for Service Delivery Platforms (SDPs). In this context, a flexible SDF for telecommunications may serve operators), the SDF allows them to re-use their service enablers, to expose network capabilities. This is the place where a NGN SDF is capable of adding further value-add, the SDF may serve for legacy as well

  4. Luminosity Stability Issues for the TESLA Beam Delivery System (BDS)

    E-Print Network [OSTI]

    Luminosity Stability Issues for the TESLA Beam Delivery System (BDS) Nicholas Walker1 (DESY, Germany) Andrzej Wolski2 (Daresbury Laboratory, UK) TESLA 2000-22 October 17, 2000 1 Introduction Given of ground motion and vibration in linear colliders both for TESLA and NLC/JLC (see for example [1

  5. Distributed Power Delivery for Energy Efficient and Low Power Systems

    E-Print Network [OSTI]

    Friedman, Eby G.

    Distributed Power Delivery for Energy Efficient and Low Power Systems Selc¸uk K¨ose Department are needed to determine the location of these on-chip power supplies and decoupling capacitors. In this paper, the optimal location of the power supplies and decoupling capacitors is determined for different size

  6. Time-Critical Data Delivery in Wireless Sensor Networks

    E-Print Network [OSTI]

    Roedig, Utz

    topology con- trol mechanisms to ensure timely data delivery and reliability control mechanisms to deal refinery in Portugal is used to define protocol requirements. The paper details a TinyOS implementation routing, topology control and reliability control mechanisms to achieve the set goals. This protocol

  7. Rural Microfinance Service Delivery: Gaps, Inefficiencies and Emerging Solutions

    E-Print Network [OSTI]

    Parikh, Tapan S.

    . Historically it has proved difficult to provide sustainable micro- financial services to remote rural clients significant challenges in maturing and scaling to sustainability. We will look at three of the major tasks, 2) management and processing of data at the institutional level and 3) the collection and delivery

  8. Creating Efficiencies in Last Mile Delivery through Workforce

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    objectives · Extend the planning horizon to achieve more efficiency · Discuss general trends in workforceCreating Efficiencies in Last Mile Delivery through Workforce Management Maciek Nowak Associate workforce management and its advantages · Discuss new research looking to expand the customer service

  9. Gene Delivery DOI: 10.1002/anie.201302820

    E-Print Network [OSTI]

    Cheng, Jianjun

    (10­25 peptide residues) and lack adequate cationic charge to efficiently condense and deliver genes vehicles to improve delivery efficiencies.[11] We recently developed high-molecular-weight (MW), cationic efficiency and chemotoxicity of these polymeric vectors are often closely related to the density

  10. Hydrogen Delivery Analysis Amgad Elgowainy (ANL), Marianne Mintz

    E-Print Network [OSTI]

    Hydrogen Truck Liquid Hydrogen Truck Terminal H2 Transmission Compressor H2 Forecourt Compressor Hydrogen Storage Options Geologic gas storage Low cost for very large amounts of hydrogen May not be convenientlyHydrogen Delivery Analysis Models Amgad Elgowainy (ANL), Marianne Mintz (ANL), Jerry Gillette (ANL

  11. Project Startup: Evaluating Coca-Cola's Class 8 Hybrid-Electric Delivery Trucks (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2011-03-01T23:59:59.000Z

    Fact sheet describing the project startup for evaluating Coca-Cola's Class 8 hybrid-electric delivery trucks.

  12. DOE and FreedomCAR and Fuel Partnership Hydrogen Delivery and...

    Broader source: Energy.gov (indexed) [DOE]

    Technical Teams for Delivery, Storage, and Fuels Pathway Integration (including automobile and energy company representatives), analysts, and national laboratories....

  13. Enterprise Assessments Targeted Review, Argonne National Laboratory...

    Energy Savers [EERE]

    Targeted Review, Argonne National Laboratory - November 2014 Enterprise Assessments Targeted Review, Argonne National Laboratory - November 2014 November 2014 Review of the...

  14. A Prospective Target for Advanced Biofuel Production

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Prospective Target for Advanced Biofuel Production A Prospective Target for Advanced Biofuel Production Print Thursday, 02 February 2012 13:34 The sesquiterpene bisabolene was...

  15. A battle with superbugs : New compounds and targets against drug-resistant pathogens

    E-Print Network [OSTI]

    Haste, Nina M.

    2012-01-01T23:59:59.000Z

    Product Marinopyrrole A against MRSA, abstr F1-1501. In 49thB. (2011). Five decades of MRSA: controversy and uncertaintyin community- associated MRSA pathogenesis. Trends Microbiol

  16. Structure-based drug mechanism study and inhibitor design targeting tuberculosis

    E-Print Network [OSTI]

    Wang, Feng

    2009-05-15T23:59:59.000Z

    ...........................................................................................................40 Cloning, Expression and Purification ...........................................................40 Synthesis of the INH-NAD, PNH-NAD and BZH-NAD Adducts...............41 InhA Activity Assay..............................39 Figure 13 Crystal Structure of S94A Bound with the INH-NAD Adduct. ....................48 Figure 14 Synthesis of INH-NAD, BZH-NAD, and PNH-NAD...................................51 Figure 15 Surface Diagram of InhA in Complex with Hydrazide...

  17. E-Print Network 3.0 - anti-filarial drug target Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences 24 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: the Pharmaceutical Industry History,...

  18. E-Print Network 3.0 - anti-epileptogenic drug targets Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences 19 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School Summary: the Pharmaceutical Industry History,...

  19. Biosynthesis pathway & transport of endotoxin - promising antibacterial drug targets in the Burkholderia cepacia Complex (BCC)

    E-Print Network [OSTI]

    Bodewits, Karin

    2011-11-23T23:59:59.000Z

    Burkholderia cepacia complex (Bcc) species are opportunistic pathogens in patients with cystic fibrosis (CF), which are able to cause lethal infections. The Bcc are inherently resistant to most classes of antibiotics, ...

  20. Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

    E-Print Network [OSTI]

    Taipale, Mikko

    The interaction between the HSP90 chaperone and its client kinases is sensitive to the conformational status of the kinase, and stabilization of the kinase fold by small molecules strongly decreases chaperone interaction. ...

  1. E-Print Network 3.0 - applications predicting drug-target Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Beijing Collection: Computer Technologies and Information Sciences 40 Optimal Halbach permanent magnet designs for maximally pulling and pushing nanoparticles Summary: on magnetic...

  2. CHARACTERIZATION OF MYCOSIN FAMILY PROTEASES, NOVEL DRUG TARGETS OF MYCOBACTERIUM TUBERCULOSIS

    E-Print Network [OSTI]

    Baird, Hilary

    2007-09-17T23:59:59.000Z

    in the cloning process because of the conservation of the Mycosins active sites. The most potent inhibitor will be able to bind all five Mycosins. Several sequence alignments have also been included to help characterize the Mycosin-1 protein. The evidence...

  3. A battle with superbugs : New compounds and targets against drug-resistant pathogens

    E-Print Network [OSTI]

    Haste, Nina M.

    2012-01-01T23:59:59.000Z

    small-scale expression (~10 ml) check on each of the four-deletion mutants was performed using a nickel- resin purification

  4. Energy Storage & Delivery The goal of this project is to deliver measurement methods specific to

    E-Print Network [OSTI]

    Energy Storage & Delivery Materials The goal of this project is to deliver measurement methods specific to polymeric and organic materials needed in next generation energy storage and delivery. · The NIST team is works closely with leaders in the energy storage and delivery field, including General

  5. Human SCO1 and SCO2 have independent, cooperative functions in copper delivery

    E-Print Network [OSTI]

    Shoubridge, Eric

    Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c understood, roles in copper delivery to cytochrome c oxidase (COX). Mutations in these genes pro- duce tissue copper delivery pathway in SCO1 and SCO2 patient backgrounds. Immunoblot analysis of patient cell lines

  6. Progress with developing a target for magnetized target fusion

    SciTech Connect (OSTI)

    Wysocki, F.J.; Chrien, R.E.; Idzorek, G.; Oona, H.; Whiteson, D.O.; Kirkpatrick, R.C.; Lindemuth, I.R.; Sheehey, P.T.

    1997-09-01T23:59:59.000Z

    Magnetized Target Fusion (MTF) is an approach to fusion where a preheated and magnetized plasma is adiabatically compressed to fusion conditions. Successful MTF requires a suitable initial target plasma with an embedded magnetic field of at least 5 T in a closed-field-line topology, a density of roughly 10{sup 18} cm{sup {minus}3}, a temperature of at least 50 eV, and must be free of impurities which would raise radiation losses. Target plasma generation experiments are underway at Los Alamos National Laboratory using the Colt facility; a 0.25 MJ, 2--3 {micro}s rise-time capacitor bank. The goal of these experiments is to demonstrate plasma conditions meeting the minimum requirements for a MTF initial target plasma. In the first experiments, a Z-pinch is produced in a 2 cm radius by 2 cm high conducting wall using a static gas-fill of hydrogen or deuterium gas in the range of 0.5 to 2 torr. Thus far, the diagnostics include an array of 12 B-dot probes, framing camera, gated OMA visible spectrometer, time-resolved monochrometer, filtered silicon photodiodes, neutron yield, and plasma-density interferometer. These diagnostics show that a plasma is produced in the containment region that lasts roughly 10 to 20 {micro}s with a maximum plasma density exceeding 10{sup 18} cm{sup {minus}3}. The experimental design and data are presented.

  7. Delivery of cationic polymer-siRNA nanoparticles for gene therapies in neural regeneration

    SciTech Connect (OSTI)

    Liang, Yanran [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Liu, Zhonglin, E-mail: zhonglinliu@126.com [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Shuai, Xintao; Wang, Weiwei [School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China (China)] [School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China (China); Liu, Jun [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Bi, Wei [Department of Neurology, The First Affiliated Hospital of Jinan University, No. 613, West Huangpu Road, Guangzhou 510630, People's Republic of China (China)] [Department of Neurology, The First Affiliated Hospital of Jinan University, No. 613, West Huangpu Road, Guangzhou 510630, People's Republic of China (China); Wang, Chuanming; Jing, Xiuna; Liu, Yunyun [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Tao, Enxiang, E-mail: taoenxiang@yahoo.com.cn [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)

    2012-05-18T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Nogo receptor can inhibit growth of injured axons, thus affecting neural regeneration. Black-Right-Pointing-Pointer The delivery of siRNA is crucial to inhibit NgR expression in NSCs. Black-Right-Pointing-Pointer Non-viral vector PEG-PEI condensed siRNA targeting NgR into nanoscale particles. Black-Right-Pointing-Pointer PEG-PEI/siRNA at N/P = 15 displayed high transfection efficiency and low cytotoxicity. Black-Right-Pointing-Pointer PEG-PEI has great potential in carrying siRNA to diminish the gene expression in NSCs. -- Abstract: The therapeutic applications of neural stem cells (NSCs) have potential to promote recovery in many obstinate diseases in central nervous system. Regulation of certain gene expressions using siRNA may have significant influence on the fate of NSC. To achieve the optimum gene silencing effect of siRNA, non-viral vector polyethylene glycol-polyethyleneimine (PEG-PEI) was investigated in the delivery of siRNA to NSCs. The characteristics of PEG-PEI/siRNA polyplexes were detected by scanning electron microscopy (SEM). The effects of nanoparticles on cell viability were measured via CCK-8 assay. In addition, the transfection efficiency was evaluated by fluorescence microscope and flow cytometry, and real-time PCR and Western Blot were employed to detect the gene inhibition effect of siRNA delivered by PEG-PEI. The SEM micrographs showed that PEG-PEI could condense siRNA to form diffuse and spherical nanoparticles. The cytotoxicity of PEG-PEI/siRNA nanocomplexes (N/P = 15) was significantly lower when compared with that of Lipofectamine 2000/siRNA (P < 0.05). Moreover, the highest transfection efficiency of PEG-PEI/siRNA nanoparticles was obtained at an N/P ratio of 15, which was better than that achieved in the transfection using Lipofectamine 2000 (P < 0.05). Finally, the gene knockdown effect of PEG-PEI/siRNA nanoparticles was verified at the levels of mRNA and protein. These results suggest that PEG-PEI may potentially be used as a siRNA delivery vector for neural regeneration therapy.

  8. Using computational fluid dynamics (CFD) to improve the bi-directional nasal drug delivery concept M Kleven1,2

    E-Print Network [OSTI]

    Reimers, Martin

    M Kleven1,2 , MC Melaaen2 , M Reimers3 , JS Røtnes4,5 , L Aurdal5,6 , PG Djupesland7 ABSTRACT Nasal

  9. Hydrogels as Biomaterials: Infinite Possibilities in Bionanotechnology, Drug Delivery, Biological Recognition,Tissue Engineering, and Pure Scientific Fun!

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    the versatility of these biopolymeric materials. Of specific interest are applications requiring the patterning

  10. In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles

    E-Print Network [OSTI]

    Miller, Michelle Teresa

    2009-01-01T23:59:59.000Z

    Cancer is the collective group of diseases distinguished by uninhibited growth and spread of abnormal cells. It often results in death if the spread is not controlled. Most cancers are treated by surgery, radiation, ...

  11. Target

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security AdministrationcontrollerNanocrystallineForeign ObjectOUR8, 2013 FINAL MEETING SUMMARY7,TankLifetime

  12. Targets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassiveSubmittedStatus TomAboutManus Site-Inactive TWPCarbonTakeRVTape Mounts

  13. Cellular delivery and site-specific targeting of organic fluorophores for super-resolution imaging in living cells

    E-Print Network [OSTI]

    Uttamapinant, Chayasith

    2013-01-01T23:59:59.000Z

    Recent advances in super-resolution fluorescence microscopy have pushed the spatial resolution of biological imaging down to a few nanometers. The key element to the development of such imaging modality is synthetic organic ...

  14. Non-PGM Target Update

    Broader source: Energy.gov (indexed) [DOE]

    at 0.80 V set for a measured activity target of 11 Acm 3 at 0.90 V, iR-corrected. (Equivalent to 300 Acm 3 at 0.80 V assuming 70 mVdec Tafel slope.) Consistent criteria...

  15. The HERMES Polarized Hydrogen Internal Gas Target

    E-Print Network [OSTI]

    internal gas targets. The HERMES hydrogen target is an internal polarized gas target using the storage cell frame on the right. atomic hydrogen beam and focuses it into a storage cell. The storage cellThe HERMES Polarized Hydrogen Internal Gas Target J. Stewart for The HERMES Collaboration

  16. Neuroimaging for drug addiction and related behaviors

    SciTech Connect (OSTI)

    Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

    2011-10-01T23:59:59.000Z

    In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

  17. Multistage nanoparticle delivery system for deep penetration into tumor

    E-Print Network [OSTI]

    Wong, Cliff

    Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...

  18. Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding

    E-Print Network [OSTI]

    Jayaram, Bhyravabotla

    Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding energy component analysis that conveys information on the physicochemical forces driving the protein for a specific protein target if not in the general case. It is here that the free energy component analysis

  19. Frontiers in drug discovery Integrating chemistry and biology in the search for the next generation of therapeutics.

    E-Print Network [OSTI]

    Cai, Long

    Frontiers in drug discovery Integrating chemistry and biology in the search for the next generation a target,generating a lead molecule,opti- mizing its properties and then proceeding to preclinical to creating the next generation of therapeutic agents. Basic advances at the interface of chemistry

  20. An overview of power delivery and laser damage in fibers

    SciTech Connect (OSTI)

    Harrington, J.A. [Rutgers Univ., Piscataway, NJ (United States)

    1997-12-01T23:59:59.000Z

    Fiber optic delivery systems are an important component of high power laser systems used for applications ranging from laser surgery to industrial cutting and welding. Conventional silica fiber optics may be used to deliver Nd:YAG laser powers in excess of 2,000 W whereas lasers operating beyond 2 {mu}m require non-silica fiber optics. Specifically, IR transmissive fiber optics for Er:YAG (3 {mu}m) or CO{sub 2} (10.6 {mu}m) laser beam delivery require the use of special fiber optics such as sapphire, fluoride or chalcogenide glass, or hollow waveguides. The optical and mechanical properties of these unique guides and their power handling capability are reviewed along with those of silica fibers operating in the UV and near IR wavelength region of the spectrum.

  1. Rethinking Americas Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    treatment); health care costs (drug-related illnesses, injuries); reduced performance in school; reduced performance at workplace; poor parenting, child abuse;

  2. Adaptive Liver Stereotactic Body Radiation Therapy: Automated Daily Plan Reoptimization Prevents Dose Delivery Degradation Caused by Anatomy Deformations

    SciTech Connect (OSTI)

    Leinders, Suzanne M. [Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Delft University of Technology, Delft (Netherlands); Breedveld, Sebastiaan; Mndez Romero, Alejandra [Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Schaart, Dennis [Delft University of Technology, Delft (Netherlands); Seppenwoolde, Yvette, E-mail: y.seppenwoolde@erasmusmc.nl [Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Heijmen, Ben J.M. [Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)

    2013-12-01T23:59:59.000Z

    Purpose: To investigate how dose distributions for liver stereotactic body radiation therapy (SBRT) can be improved by using automated, daily plan reoptimization to account for anatomy deformations, compared with setup corrections only. Methods and Materials: For 12 tumors, 3 strategies for dose delivery were simulated. In the first strategy, computed tomography scans made before each treatment fraction were used only for patient repositioning before dose delivery for correction of detected tumor setup errors. In adaptive second and third strategies, in addition to the isocenter shift, intensity modulated radiation therapy beam profiles were reoptimized or both intensity profiles and beam orientations were reoptimized, respectively. All optimizations were performed with a recently published algorithm for automated, multicriteria optimization of both beam profiles and beam angles. Results: In 6 of 12 cases, violations of organs at risk (ie, heart, stomach, kidney) constraints of 1 to 6 Gy in single fractions occurred in cases of tumor repositioning only. By using the adaptive strategies, these could be avoided (<1 Gy). For 1 case, this needed adaptation by slightly underdosing the planning target volume. For 2 cases with restricted tumor dose in the planning phase to avoid organ-at-risk constraint violations, fraction doses could be increased by 1 and 2 Gy because of more favorable anatomy. Daily reoptimization of both beam profiles and beam angles (third strategy) performed slightly better than reoptimization of profiles only, but the latter required only a few minutes of computation time, whereas full reoptimization took several hours. Conclusions: This simulation study demonstrated that replanning based on daily acquired computed tomography scans can improve liver stereotactic body radiation therapy dose delivery.

  3. Feasibility Study: Ductless Hydronic Distribution Systems with Fan Coil Delivery

    SciTech Connect (OSTI)

    Springer, D.; Dakin, B.; Backman, C.

    2012-07-01T23:59:59.000Z

    The primary objectives of this study are to estimate potential energy savings relative to conventional ducted air distribution, and to identify equipment requirements, costs, and barriers with a focus on ductless hydronic delivery systems that utilize water-to-air terminal units in each zone. Results indicate that annual heating and cooling energy use can be reduced by up to 27% assuming replacement of the conventional 13 SEER heat pump and coil with a similarly rated air-to-water heat pump.

  4. FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS

    E-Print Network [OSTI]

    Flynn, Colleen A.

    2011-12-31T23:59:59.000Z

    Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ...

  5. LIFE Target Fabrication Research Plan Sept 2008

    SciTech Connect (OSTI)

    Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

    2008-11-10T23:59:59.000Z

    The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

  6. Pricing in the Market for Anticancer Drugs

    E-Print Network [OSTI]

    Howard, David H.

    In 2011, Bristol-Myers Squibb set the price of its newly approved melanoma drug ipilimumab brand name Yervoyat $120,000 for a course of therapy. The drug was associated with an incremental increase in life expectancy of ...

  7. Chemical Innovation in Drug Dr Matthew Fuchter

    E-Print Network [OSTI]

    Chemical Innovation in Drug Discovery Dr Matthew Fuchter Lecturer in Synthetic and Medicinal&D Spending and Output #12;Chemical Innovation Impact Discovery Development Basic research: years 0-3 Pre 3, File DRUG Chemical start point Hit to lead Preclinical Assessment Synthetic Chemistry Chemistry

  8. The World of Youthful Drug Use

    E-Print Network [OSTI]

    Blumer, Herbert; Sutter, Alan; Smith, Roger; Ahmed, Samir

    2000-04-01T23:59:59.000Z

    they meet the fact that the use of drugs is illegal and exposes them to arrest and criminal prosecution. It was obvious that such kinds of information could be secured: only from the youths who were themselves in the drug using world. We could not rely on a...

  9. New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis

    E-Print Network [OSTI]

    N. Panja; A. K. Chattopadhyay

    2014-12-05T23:59:59.000Z

    We report results of an experimental study, complemented by detailed statistical analysis of the experimental data, on the development of a more effective control method of drug delivery using a pH sensitive acrylic polymer. New copolymers based on acrylic acid and fatty acid are constructed from dodecyl castor oil and a tercopolymer based on methyl methacrylate, acrylic acid and acryl amide were prepared using this new approach. Water swelling characteristics of fatty acid, acrylic acid copolymer and tercopolymer respectively in acid and alkali solutions have been studied by a step-change method. The antibiotic drug cephalosporin and paracetamol have also been incorporated into the polymer blend through dissolution with the release of the antibiotic drug being evaluated in bacterial stain media and buffer solution. Our results show that the rate of release of paracetamol getss affected by the pH factor and also by the nature of polymer blend. Our experimental data have later been statistically analyzed to quantify the precise nature of polymer decay rates on the pH density of the relevant polymer solvents. The time evolution of the polymer decay rates indicate a marked transition from a linear to a strictly non-linear regime depending on the whether the chosen sample is a general copolymer (linear) or a tercopolymer (non-linear). Non-linear data extrapolation techniques have been used to make probabilistic predictions about the variation in weight percentages of retained polymers at all future times, thereby quantifying the degree of efficacy of the new method of drug delivery.

  10. Cascaded target normal sheath acceleration

    SciTech Connect (OSTI)

    Wang, W. P.; Shen, B. F.; Zhang, X. M.; Wang, X. F.; Xu, J. C.; Zhao, X. Y.; Yu, Y. H.; Yi, L. Q.; Shi, Y.; Zhang, L. G.; Xu, T. J.; Xu, Z. Z. [State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)] [State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)

    2013-11-15T23:59:59.000Z

    A cascaded target normal sheath acceleration (TNSA) scheme is proposed to simultaneously increase energy and improve energy spread of a laser-produced mono-energetic proton beam. An optimum condition that uses the maximum sheath field to accelerate the center of the proton beam is theoretically found and verified by two-dimensional particle-in-cell simulations. An initial 10 MeV proton beam is accelerated to 21 MeV with energy spread decreased from 5% to 2% under the optimum condition during the process of the cascaded TNSA. The scheme opens a way to scale proton energy lineally with laser energy.

  11. Targets and processes for fabricating same

    DOE Patents [OSTI]

    Cowan, Thomas (Dresden, DE); Malekos, Steven (Reno, NV); Korgan, Grant (Reno, NV); Adams, Jesse (Reno, NV); Sentoku, Yasuhiko (Reno, NV); Le Galloudec, Nathalie (Reno, NV); Fuchs, Julien (Paris, FR)

    2012-07-24T23:59:59.000Z

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  12. Review of the Renewable Energy Target

    E-Print Network [OSTI]

    Peters, Richard

    Review of the Renewable Energy Target Response to Expert Panel's Call for Submissions Paper #12;NSW Government Submission to the Review of the Renewable Energy Target, May 2014 2/20 Contents EXECUTIVE SUMMARY........................................................................................................................... 3 RENEWABLE ENERGY IN NSW

  13. Qualified Target Industry Tax Refund (Florida)

    Broader source: Energy.gov [DOE]

    The Qualified Target Industry Tax Refund incentive is available for companies that create high wage jobs in targeted high value-added industries. The incentive refunds up to $3,000 per new full...

  14. Nanoparticles for targeting the infarcted heart

    E-Print Network [OSTI]

    Dvir, Tal

    We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...

  15. E-Print Network 3.0 - adverse antiepileptic drug Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Drug ad (intrinsic bias) Summary: Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company... Dosage Same or different? A drug in a different...

  16. WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    14 WISDOM: A Grid-Enabled Drug Discovery Initiative Against Malaria Vincent Breton, Doman Kim ................................................................................ 354 14.2 Grid-Enabled Drug Discovery .................................................. 354 14.2.1 In Silico Drug Discovery: Requirements and Grid Added Value

  17. Development of granular target for CADS

    E-Print Network [OSTI]

    McDonald, Kirk

    Subcritical core/blanket #12;· Solid target options, which consist of a solid material in the form of rods 5L/s Width of Lacuna 7cm #12;CW-316LSS The free surface in windowless target Water loop test-Parallel CFD (GPU) for Beam-Target-Coupled 15360 cores Test by the electron beam coupled with water Annular

  18. THE HANFORD WASTE FEED DELIVERY OPERATIONS RESEARCH MODEL

    SciTech Connect (OSTI)

    BERRY J; GALLAHER BN

    2011-01-13T23:59:59.000Z

    Washington River Protection Solutions (WRPS), the Hanford tank farm contractor, is tasked with the long term planning of the cleanup mission. Cleanup plans do not explicitly reflect the mission effects associated with tank farm operating equipment failures. EnergySolutions, a subcontractor to WRPS has developed, in conjunction with WRPS tank farms staff, an Operations Research (OR) model to assess and identify areas to improve the performance of the Waste Feed Delivery Systems. This paper provides an example of how OR modeling can be used to help identify and mitigate operational risks at the Hanford tank farms.

  19. Computer controlled feed delivery system for feed trucks

    E-Print Network [OSTI]

    Holt, Gregory Alan

    2012-06-07T23:59:59.000Z

    /ft), respectively. These values were selected for two reasons: 1) limitations of the model and 2) ease of testing. The scaled-down feed wagon was limited to a bed conveyor speed of 4. 27 m/min (14 fpm). Therefore, the maximum delivery rate/ground speed... the proportional control valve. 22 LIST OF FIGURES (continued) Page Figure 13. Picture of proportional control valve. . 22 Figure 14. Circuit diagram of the hydraulic system on the scaled-down model. . 24 Figure 15. Photograph of the collection box sitting...

  20. A Fast Delivery Protocol for Total Order Broadcasting

    SciTech Connect (OSTI)

    Ou, Li [Tennessee Technological University; He, X. [Tennessee Technological University; Engelmann, Christian [ORNL; Scott, Stephen L [ORNL

    2007-01-01T23:59:59.000Z

    The conclusions of this report are: (1) Fast delivery protocol reduces the latency of message ordering for idle systems and keep comparable performances with communication history algorithms for busy systems; (2) The protocol optimizes the total ordering process by waiting for messages only from a subset of the machines in the group; and (3) The fast acknowledgment aggressively acknowledges total order messages to reduce the latency for idle system, and it is smart enough to hold the acknowledgments when the network communication is heavy.

  1. Comments of Oncor Electric Delivery Company LLC | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTieCelebrate Earth Codes andDepartment|Crow WingOncor Electric Delivery

  2. U.S. Natural Gas % of Total Residential Deliveries (Percent)

    Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines AboutDecemberSteamYearTexas--StateWinter 2013-14 WellsDecade Year-0Formulation/Deliveries

  3. U.S. Natural Gas International Deliveries (Million Cubic Feet)

    Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines AboutDecemberSteamYearTexas--StateWinter 2013-14 WellsDecadeCubicYearDecadeDeliveries

  4. U.S. Natural Gas Interstate Deliveries (Million Cubic Feet)

    Annual Energy Outlook 2013 [U.S. Energy Information Administration (EIA)]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelines AboutDecemberSteamYearTexas--StateWinter 2013-14Deliveries (Million Cubic Feet) U.S.

  5. Electricity Delivery and Energy Reliability | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeat PumpRecord ofESPC ENABLE: ECM Summaryandand TranscriptsElectricity Delivery and

  6. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of Energyof the AmericasDOE-STD-3020-2005CodeErnest J.Delivery andDeliveryand

  7. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of Energyof the AmericasDOE-STD-3020-2005CodeErnest J.Delivery andDeliveryandand

  8. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of Inspector GeneralDepartment of Energyof the AmericasDOE-STD-3020-2005CodeErnest J.Delivery

  9. US DRIVE Hydrogen Delivery Technical Team Roadmap | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up from theDepartment of Dept. of Energy,UCOR Contract &onEnergyGridDelivery

  10. FY 2014 Budget Request for the Office of Electricity Delivery and Energy Reliability

    Broader source: Energy.gov [DOE]

    Table showing the FY 2012 Current Appropriation, the FY 2013 Annualized Continuing Resolution, and the FY 2014 Congressional Request for the Office of Electricity Delivery and Energy Reliability.

  11. The Role of Public Utility Commissions in Energy Efficiency Program Delivery

    Broader source: Energy.gov [DOE]

    This presentation, given through the DOE's Technical Assitance Program (TAP), addresses the role of public utility commissions in energy efficiency program delivery. Presented on August 31, 2011.

  12. U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY AND...

    Office of Environmental Management (EM)

    U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY 10 ENVIRONMENTAL ASSESSMENT PUBLIC SCOPING MEETING U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY...

  13. Vectren Energy Delivery of Indiana (Electric)- Commercial New Construction Rebates (Indiana)

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers commercial customers in Indiana electric rebates for the installation of certain types of equipment in newly constructed buildings. Prescriptive and performance based...

  14. DOE Fuel Cell Technologies Office Record 13013: H2 Delivery Cost...

    Office of Environmental Management (EM)

    current, and projected costs for delivering and dispensing hydrogen. DOE Hydrogen and Fuel Cells Program Record 13013 More Documents & Publications Hydrogen Delivery Roadmap US...

  15. 2011 Annual Planning Summary for Electricity Delivery and Energy Reliability (OE)

    Broader source: Energy.gov [DOE]

    The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2011 and 2012 within the Office of Electricity Delivery and Energy Reliability (OE).

  16. Drugs and oil flow through the Eagle Ford Shale.

    E-Print Network [OSTI]

    Marks, Michael Perry

    2014-01-01T23:59:59.000Z

    ??This report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region (more)

  17. E-Print Network 3.0 - antiparasitic drugs phosphonohydroxamic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pg. 1: Eligible Expenses & Documentation Pg. 2: Over-The-Counter Changes due to Health Care Reform Summary: and "reasonable limits" on OTC drugs, please see -http... drugs...

  18. antiepileptic drug development: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of drug design and development Bommarius Reading Jan 15 Tutorial Sherrill, David 28 Assessing the impact of tumor evolution on oncology drug development and commercialization MIT...

  19. Progress in chemical processing of LEU targets for {sup 99}Mo production -- 1997

    SciTech Connect (OSTI)

    Vandegrift, G.F.; Conner, C.; Sedlet, J.; Wygmans, D.G. [Argonne National Lab., IL (United States); Wu, D. [Univ. of Illinois, Urbana, IL (United States); Iskander, F.; Landsberger, S. [Univ. of Texas, Austin, TX (United States)

    1997-10-01T23:59:59.000Z

    Presented here are recent experimental results of the continuing development activities associated with converting current processes for producing fission-product {sup 99}Mo from targets using high-enriched uranium (HEU) to low-enriched uranium (LEU). Studies were focused in four areas: (1) measuring the chemical behavior of iodine, rhodium, and silver in the LEU-modified Cintichem process, (2) performing experiments and calculations to assess the suitability of zinc fission barriers for LEU metal foil targets, (3) developing an actinide separations method for measuring alpha contamination of the purified {sup 99}Mo product, and (4) developing a cooperation with Sandia National Laboratories and Los Alamos National Laboratory that will lead to approval by the US Federal Drug Administration for production of {sup 99}Mo from LEU targets. Experimental results continue to show the technical feasibility of converting current HEU processes to LEU.

  20. Spatiotemporal controlled delivery of nanoparticles to injured vasculature

    E-Print Network [OSTI]

    Chan, Juliana Maria

    2010-01-01T23:59:59.000Z

    Complex multimodal nanoparticles (NP) that target and deliver therapeutic agents to a site of disease are a promising direction in modem medicine. As a starting point for innovation, we designed a hybrid NP system combining ...

  1. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21T23:59:59.000Z

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  2. Fabrication of boron sputter targets

    DOE Patents [OSTI]

    Makowiecki, Daniel M. (Livermore, CA); McKernan, Mark A. (Livermore, CA)

    1995-01-01T23:59:59.000Z

    A process for fabricating high density boron sputtering targets with sufficient mechanical strength to function reliably at typical magnetron sputtering power densities and at normal process parameters. The process involves the fabrication of a high density boron monolithe by hot isostatically compacting high purity (99.9%) boron powder, machining the boron monolithe into the final dimensions, and brazing the finished boron piece to a matching boron carbide (B.sub.4 C) piece, by placing aluminum foil there between and applying pressure and heat in a vacuum. An alternative is the application of aluminum metallization to the back of the boron monolithe by vacuum deposition. Also, a titanium based vacuum braze alloy can be used in place of the aluminum foil.

  3. Ignition of deuterium-trtium fuel targets

    DOE Patents [OSTI]

    Musinski, Donald L. (Saline, MI); Mruzek, Michael T. (Britton, MI)

    1991-01-01T23:59:59.000Z

    A method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom.

  4. Ignition of deuterium-tritium fuel targets

    DOE Patents [OSTI]

    Musinski, D.L.; Mruzek, M.T.

    1991-08-27T23:59:59.000Z

    Disclosed is a method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom. 5 figures.

  5. Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile

    SciTech Connect (OSTI)

    Koenig, Xaver; Kovar, Michael; Rubi, Lena; Mike, Agnes K.; Lukacs, Peter; Gawali, Vaibhavkumar S.; Todt, Hannes [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Hilber, Karlheinz, E-mail: karlheinz.hilber@meduniwien.ac.at [Center for Physiology and Pharmacology, Department of Neurophysiology and -pharmacology, Medical University of Vienna, 1090 Vienna (Austria); Sandtner, Walter [Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna (Austria)

    2013-12-01T23:59:59.000Z

    The plant alkaloid ibogaine has promising anti-addictive properties. Albeit not licenced as a therapeutic drug, and despite hints that ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Na{sub v}1.5 sodium and Ca{sub v}1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (? 10 ?M) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias. - Highlights: We study effects of anti-addiction drug ibogaine on ionic currents in cardiomyocytes. We assess the cardiac ion channel profile of ibogaine. Ibogaine inhibits hERG potassium, sodium and calcium channels. Ibogaines effects on ion channels are a potential source of cardiac arrhythmias. 18-Methoxycoronaridine has a lower affinity for cardiac ion channels than ibogaine.

  6. Experimental Target Injection and Tracking System

    SciTech Connect (OSTI)

    Petzoldt, R.W. [General Atomics (United States); Alexander, N.B. [General Atomics (United States); Drake, T.J. [General Atomics (United States); Goodin, D.T. [General Atomics (United States); Stemke, R.W. [General Atomics (United States); Jonestrask, K

    2003-07-15T23:59:59.000Z

    Targets must be injected into an IFE power plant with an accuracy of and plusmn; 5 mm at a rate of approximately 5 to 10 each second. Targets must be tracked very accurately to allow driver beams to be aligned with defined points on the targets with accuracy {+-}200{mu}m for indirect drive and {+-}20{mu}m for direct drive. An experimental target injection and tracking system has been designed and is being constructed at General Atomics to investigate injection and tracking of both direct drive and indirect drive targets. The design is modular to allow testing of alternate target acceleration and tracking methods. The injector system will be used as a tool for testing the survivability of various target designs and provide feed back to the target designers. This 30 m long system will be the centerpiece of a Facility for developing IFE target fabrication and injection technologies. A high-speed high-flow gas valve (designed and built by Oak Ridge National Laboratory) will provide helium propellant gas to the targets. To avoid target damage from excessive acceleration, an 8 m gun barrel is being built to achieve 400 m/s target speed while not exceeding 10,000 m/s{sup 2} acceleration. Direct-drive targets are protected in the barrel by sabots that are spring loaded to separate into two halves after acceleration. A sabot deflector directs the sabot halves away from the target injection path. Gas expansion chambers and orifices, keep propellant gas out of the target-tracking region. Targets will be optically tracked with laser beams and line scan cameras. High-speed computations will calculate target position in less than 2 ms based on the output from the line-scan cameras. Target position and arrival time to a plane in the reaction chamber center will be predicted in real-time based on early target position measurements. The system design, construction progress, and early testing results will be presented.

  7. Intradermal needle-free powdered drug injection

    E-Print Network [OSTI]

    Liu, John (John Hsiao-Yung)

    2012-01-01T23:59:59.000Z

    This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis ...

  8. Alcohol and Other Drugs Education and Prevention

    E-Print Network [OSTI]

    Free Workplace Policy. 2.0 POLICY STATEMENT In compliance with the federal government's Drug Free, because of Mines' status as a federal contractor and grant recipient and because marijuana use is still

  9. Economic and Conservation Evaluation of Capital Renovation Projects: Edinburg Irrigation District Hidalgo County No. 1 - 72" Pipeline Replacing Delivery Canal and Multi-Size Pipeline Replacing Delivery Canal

    E-Print Network [OSTI]

    Rister, M. Edward; Lacewell, Ronald D.; Sturdivant, Allen W.; Robinson, John R.C.; Popp, Michael C.; Ellis, John R.

    ). Both nominal and real, expected economic and financial costs of water and energy savings are identified throughout the anticipated useful lives for both components of the proposed project (i.e., 72" pipeline replacing a segment of delivery canal along...

  10. Application of Target Value Design to Energy Efficiency Investments

    E-Print Network [OSTI]

    Lee, Hyun Woo

    2012-01-01T23:59:59.000Z

    2006). Lean Processes for Sustainable Project Delivery. Green Buildings: Process Improvements for Sustainableprocess that can achieve high-performance, low- energy, sustainable

  11. Explanations of FreedomCAR/DOE Hydrogen Storage Technical Targets...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Explanations of FreedomCARDOE Hydrogen Storage Technical Targets Explanations of FreedomCARDOE Hydrogen Storage Technical Targets Summary of FreedomCAR Targets and Basis for...

  12. The study of downstream targets and other characteristics of NTT

    E-Print Network [OSTI]

    Fung, Michelle W.

    2009-01-01T23:59:59.000Z

    SAN DIEGO The Study of Downstream Targets and OtherOF THE THESIS The Study of Downstream Targets and Othera number of putative downstream targets of NTT, including

  13. Independent Oversight Targeted Review, Y-12 National Security...

    Office of Environmental Management (EM)

    Targeted Review, Y-12 National Security Complex - February 2012 Independent Oversight Targeted Review, Y-12 National Security Complex - February 2012 February 2012 Targeted Review...

  14. Independent Oversight Targeted Review, Oak Ridge National Laboratory...

    Office of Environmental Management (EM)

    Targeted Review, Oak Ridge National Laboratory - April 2014 Independent Oversight Targeted Review, Oak Ridge National Laboratory - April 2014 April 2014 Targeted Review of...

  15. Bacteria-targeting nanoparticles for managing infections

    E-Print Network [OSTI]

    Radovic-Moreno, Aleksandar Filip

    2013-01-01T23:59:59.000Z

    Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects ...

  16. POLYMER PROGRAM SEMINAR "Targeted polymeric nanoparticles

    E-Print Network [OSTI]

    Alpay, S. Pamir

    , IMS Room 20 A variety of organic and inorganic materials have been utilized to generate nanoparticles drugs for combination therapy. The surface engineering of these nanoparticles may yield them "stealth

  17. THE COMPETITIVENESS OF COMMERCIAL ELECTRIC VEHICLES IN THE LTL DELIVERY INDUSTRY

    E-Print Network [OSTI]

    Bertini, Robert L.

    of electric delivery trucks. To this end, equations linking vehicle performance to power consumption, routeTHE COMPETITIVENESS OF COMMERCIAL ELECTRIC VEHICLES IN THE LTL DELIVERY INDUSTRY: #12; #12, energy use, and costs of electric vehicles and comparable diesel internal-combustion engine vehicles

  18. A Scheme for Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara and Geoffrey Fox

    E-Print Network [OSTI]

    A Scheme for Reliable Delivery of Events in Distributed Middleware Systems Shrideep Pallickara. These interactions can be encapsulated in events. We describe a scheme for the reliable delivery of events pertaining to transactions, data interchange, system conditions and finally the search, discovery

  19. Energy-aware Georouting with Guaranteed Delivery in Wireless Sensor Networks with

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Energy-aware Georouting with Guaranteed Delivery in Wireless Sensor Networks with Obstacles E. H algorithm invokes an energy-aware Face routing that guarantees delivery. Our work is the first to optimize node using only local neighborhood information. Within this framework, energy-aware routing schemes use

  20. Microfluidic device for delivery of multiple inks for dip pen nanolithography

    E-Print Network [OSTI]

    Banerjee, Debjyoti

    Microfluidic device for delivery of multiple inks for dip pen nanolithography Juan Alberto Rivas of a microfluidic ink delivery device for delivering multiple species of inks to an array of multiple pens, as well as for maximizing the number of inks for simulta- neous patterning by DPN. The microfluidic device called "Centiwell

  1. A P2P VIDEO DELIVERY NETWORK (P2P-VDN) Kien Nguyen, Thinh Nguyen

    E-Print Network [OSTI]

    Kovchegov, Yevgeniy

    A P2P VIDEO DELIVERY NETWORK (P2P-VDN) Kien Nguyen, Thinh Nguyen School of EECS Oregon State University kovchegy@science.oregonstate.edu ABSTRACT Current video streaming and storage systems such as You- per describes a Peer-to-Peer Video Delivery Network (P2P- VDN) that provides both performance

  2. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results

    E-Print Network [OSTI]

    H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis ...........................................................................2-1 H2A Hydrogen Delivery Models 2.1.5.2 ......................................................................2-10 Refueling Station Compressor 2.1.5.3 ............................2-11 Refueling Station Liquid

  3. Tensor Target Polarization at TRIUMF

    SciTech Connect (OSTI)

    Smith, G

    2014-10-27T23:59:59.000Z

    The first measurements of tensor observables in $\\pi \\vec{d}$ scattering experiments were performed in the mid-80's at TRIUMF, and later at SIN/PSI. The full suite of tensor observables accessible in $\\pi \\vec{d}$ elastic scattering were measured: $T_{20}$, $T_{21}$, and $T_{22}$. The vector analyzing power $iT_{11}$ was also measured. These results led to a better understanding of the three-body theory used to describe this reaction. %Some measurements were also made in the absorption and breakup channels. A direct measurement of the target tensor polarization was also made independent of the usual NMR techniques by exploiting the (nearly) model-independent result for the tensor analyzing power at 90$^\\circ _{cm}$ in the $\\pi \\vec{d} \\rightarrow 2p$ reaction. This method was also used to check efforts to enhance the tensor polarization by RF burning of the NMR spectrum. A brief description of the methods developed to measure and analyze these experiments is provided.

  4. Moller Polarimetry with Atomic Hydrogen Targets

    SciTech Connect (OSTI)

    Chudakov, Eugene [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Luppov, V. [University of Michigan Spin Physics Center, Ann Arbor, MI (United States)

    2012-06-01T23:59:59.000Z

    A proposal to use polarized atomic hydrogen gas as the target for electron beam polarimetry based on the Moller scattering is described. Such a gas, stored in an ultra-cold magnetic trap, would provide a target of practically 100\\% polarized electrons. It is conceivable to reach a $\\sim$0.3\\% systematic accuracy of the beam polarimetry with such a target. Feasibility studies for the CEBAF electron beam have been performed.

  5. The design and evaluation of a water delivery system for evaporative cooling of a proton exchange membrane fuel cell

    E-Print Network [OSTI]

    Al-Asad, Dawood Khaled Abdullah

    2009-06-02T23:59:59.000Z

    An investigation was performed to demonstrate system design for the delivery of water required for evaporative cooling of a proton exchange membrane fuel cell (PEMFC). The water delivery system uses spray nozzles capable of injecting water directly...

  6. Specific and efficient in vivo delivery of DNA and siRNA by polyethylenimine and its derivatives

    E-Print Network [OSTI]

    Fortune, Jennifer A

    2010-01-01T23:59:59.000Z

    Linear polyethylenimine (PEI) is the "gold standard" of polycationic gene delivery vectors. However, little focus has been placed on enhancing or understanding the specificity of PEImediated gene delivery. Herein we evaluated ...

  7. DOE Program/Targets and Workshop Objectives

    Broader source: Energy.gov (indexed) [DOE]

    Nancy Garland DOE Hydrogen Program Fuel Cell Operation at Sub- Freezing Temperatures DOE ProgramTargets and Workshop Objectives Sub-Freezing Temperature Effects on Fuel Cells...

  8. Enterprise Assessments, Lessons Learned from Targeted Reviews...

    Energy Savers [EERE]

    purpose of these targeted assessments was to evaluate the flowdown of occupational radiation protection program requirements into work planning, control, and execution...

  9. Rapid cycling medical synchrotron and beam delivery system

    DOE Patents [OSTI]

    Peggs, Stephen G. (Port Jefferson, NY); Brennan, J. Michael (East Northport, NY); Tuozzolo, Joseph E. (Sayville, NY); Zaltsman, Alexander (Commack, NY)

    2008-10-07T23:59:59.000Z

    A medical synchrotron which cycles rapidly in order to accelerate particles for delivery in a beam therapy system. The synchrotron generally includes a radiofrequency (RF) cavity for accelerating the particles as a beam and a plurality of combined function magnets arranged in a ring. Each of the combined function magnets performs two functions. The first function of the combined function magnet is to bend the particle beam along an orbital path around the ring. The second function of the combined function magnet is to focus or defocus the particle beam as it travels around the path. The radiofrequency (RF) cavity is a ferrite loaded cavity adapted for high speed frequency swings for rapid cycling acceleration of the particles.

  10. Reliability review of the remote tool delivery system locomotor

    SciTech Connect (OSTI)

    Chesser, J.B.

    1999-04-01T23:59:59.000Z

    The locomotor being built by RedZone Robotics is designed to serve as a remote tool delivery (RID) system for waste retrieval, tank cleaning, viewing, and inspection inside the high-level waste tanks 8D-1 and 8D-2 at West Valley Nuclear Services (WVNS). The RTD systm is to be deployed through a tank riser. The locomotor portion of the RTD system is designed to be inserted into the tank and is to be capable of moving around the tank by supporting itself and moving on the tank internal structural columns. The locomotor will serve as a mounting platform for a dexterous manipulator arm. The complete RTD system consists of the locomotor, dexterous manipulator arm, cameras, lights, cables, hoses, cable/hose management system, power supply, and operator control station.

  11. Cryogenics for superconductors: Refrigeration, delivery, and preservation of the cold

    SciTech Connect (OSTI)

    Venkatarao Ganni, James Fesmire

    2012-06-01T23:59:59.000Z

    Applications in superconductivity have become widespread, enabled by advancements in cryogenic engineering. In this paper, the history of cryogenic refrigeration, its delivery, its preservation and the important scientific and engineering advancements in these areas in the last 100 years will be reviewed, beginning with small laboratory dewars to very large scale systems. The key technological advancements in these areas that enabled the development of superconducting applications at temperatures from 4 to 77 K are identified. Included are advancements in the components used up to the present state-of-the-art in refrigeration systems design. Viewpoints as both an equipment supplier and the end-user with regard to the equipment design and operations will be presented. Some of the present and future challenges in these areas will be outlined. Most of the materials in this paper are a collection of the historical materials applicable to these areas of interest.

  12. Multiple delivery cesium oven system for negative ion sources

    SciTech Connect (OSTI)

    Bansal, G.; Bhartiya, S.; Pandya, K.; Bandyopadhyay, M.; Singh, M. J.; Soni, J.; Gahlaut, A.; Parmar, K. G.; Chakraborty, A. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat 382428 (India)

    2012-02-15T23:59:59.000Z

    Distribution of cesium in large negative ion beam sources to be operational in ITER, is presently based on the use of three or more cesium ovens, which operate simultaneously and are controlled remotely. However, use of multiple Cs ovens simultaneously is likely to pose difficulties in operation and maintenance of the ovens. An alternate method of Cs delivery, based on a single oven distribution system is proposed as one which could reduce the need of simultaneous operation of many ovens. A proof of principle experiment verifying the concept of a multinozzle distributor based Cs oven has been carried out at Institute for Plasma Research. It is also observed that the Cs flux is not controlled by Cs reservoir temperature after few hours of operation but by the temperature of the distributor which starts behaving as a Cs reservoir.

  13. LN2 Dewar 42 Delivery Overfill Inlet Solution

    SciTech Connect (OSTI)

    Wu, J.; Mulholland, G.T.; /Fermilab

    1991-02-26T23:59:59.000Z

    Pressure vessels must be protected against overpressure scenarios. A scenario of particular concern is that from a high pressure LN2 pump, now standard on LN2 delivery trailers. A safety mechanism must be in place to prevent the overfilling, and subsequent overpressure from occurring because these pumps have a higher mass flow output than reasonably sized relief valves provide. The original solution to the problem was to close a valve on the fill line when a certain liquid level in the dewar is reached. The valve remains closed until the level drops below that threshold. The trigger level was about 13,000 gallons for the 20,000 gallon capacity dewar. The solution was in place from 1989 until present, 2004.

  14. Simulant Development for Hanford Double-Shell Tank Mixing and Waste Feed Delivery Testing

    SciTech Connect (OSTI)

    Gauglitz, Phillip A.; Tran, Diana N.; Buchmiller, William C.

    2012-09-24T23:59:59.000Z

    The U.S. Department of Energy Office of River Projection manages the River Protection Project, which has the mission to retrieve and treat the Hanford tank waste for disposal and close the tank farms (Certa et al. 2011). Washington River Protection Solutions, LLC (WRPS) is responsible for a primary objective of this mission which is to retrieve and transfer tank waste to the Hanford Waste Treatment and Immobilization Plant (WTP). A mixing and sampling program with four separate demonstrations is currently being conducted to support this objective and also to support activities in a plan for addressing safety concerns identified by the Defense Nuclear Facilities Safety Board related to the ability of the WTP to mix, sample, and transfer fast settling particles. Previous studies have documented the objectives, criteria, and selection of non-radioactive simulants for these four demonstrations. The identified simulants include Newtonian suspending liquids with densities and viscosities that span the range expected in waste feed tanks. The identified simulants also include non-Newtonian slurries with Bingham yield stress values that span a range that is expected to bound the Bingham yield stress in the feed delivery tanks. The previous studies identified candidate materials for the Newtonian and non-Newtonian suspending fluids, but did not provide specific recipes for obtaining the target properties and information was not available to evaluate the compatibility of the fluids and particles or the potential for salt precipitation at lower temperatures. The purpose of this study is to prepare small batches of simulants in advance of the demonstrations to determine specific simulant recipes, to evaluate the compatibility of the liquids and particles, and to determine if the simulants are stable for the potential range of test temperatures. The objective of the testing, which is focused primarily on the Newtonian and non-Newtonian fluids, is to determine the composition of simulant materials that give the desired density and viscosity or rheological parameters.

  15. Polarimeters and Energy Spectrometers for the ILC Beam Delivery System

    SciTech Connect (OSTI)

    Boogert, S.; /Royal Holloway, U. of London; Hildreth, M.; /Notre Dame U.; Kafer, D.; List, J.; Monig, K.; /DESY; Moffeit, K.C.; /SLAC; Moortgat-Pick, G.; /Durham U., IPPP; Riemann, S.; Schreiber, H.J.; Schuler, P.; /DESY; Torrence, E.; /Oregon U.; Woods, M.; /SLAC

    2009-02-24T23:59:59.000Z

    This article gives an overview of current plans and issues for polarimeters and energy spectrometers in the Beam Delivery System of the ILC. It is meant to serve as a useful reference for the Detector Letter of Intent documents currently being prepared. Concepts for high precision polarization and energy measurements exist. These concepts have resulted in detailed system layouts that are included in the RDR description for the Beam Delivery System. The RDR includes both upstream and downstream polarimeters and energy spectrometers for both beams. This provides needed complementarity and redundancy for achieving the precision required, with adequate control and demonstration of systematic errors. The BDS polarimeters and energy spectrometers need to be a joint effort of the ILC BDS team and the Detector collaborations, with collaboration members responsible for the performance and accuracy of the measurements. Details for this collaboration and assigning of responsibilities remain to be worked out. There is also a demonstrated need for Detector physicists to play an active role in the design and evaluation of accelerator components that impact beam polarization and beam energy capabilities, including the polarized source and spin rotator systems. A workshop was held in 2008 on ILC Polarization and Energy measurements, which resulted in a set of recommendations for the ILC design and operation. Additional input and action is needed on these from the Detector collaborations, the Research Director and the GDE. Work is continuing during the ILC engineering design phase to further optimize the polarimeter and energy spectrometer concepts and fully implement them in the ILC. This includes consideration for alternative methods, detailed design and cost estimates, and prototype and test beam activities.

  16. Rethinking drug policy: an integrity preserving compromise position

    E-Print Network [OSTI]

    Crispino, Azzurra

    2006-10-30T23:59:59.000Z

    Definition of Drug Types?????????????...??.. 4 2 Definition of Drug Scheduling??????????????. 5 1 CHAPTER I INTRODUCTION TO STATUS QUO DRUG POLICY The issue of how to properly regulate the use of illegal.... Legalizers are those who would make legal all currently illegal drugs. The most 3 common middle stance is that of harm reduction, which is ?an alternative approach to drug policy and treatment that focuses on minimizing the adverse effects of both...

  17. Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB

    SciTech Connect (OSTI)

    Chen, Wenjing; Biswas, Tapan; Porter, Vanessa R.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie (Michigan)

    2011-09-06T23:59:59.000Z

    The emergence of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis (TB) is a serious global threat. Aminoglycoside antibiotics are used as a last resort to treat XDR-TB. Resistance to the aminoglycoside kanamycin is a hallmark of XDR-TB. Here, we reveal the function and structure of the mycobacterial protein Eis responsible for resistance to kanamycin in a significant fraction of kanamycin-resistant Mycobacterium tuberculosis clinical isolates. We demonstrate that Eis has an unprecedented ability to acetylate multiple amines of many aminoglycosides. Structural and mutagenesis studies of Eis indicate that its acetylation mechanism is enabled by a complex tripartite fold that includes two general control non-derepressible 5 (GCN5)-related N-acetyltransferase regions. An intricate negatively charged substrate-binding pocket of Eis is a potential target of new antitubercular drugs expected to overcome aminoglycoside resistance.

  18. TARGET STATION INFRASTRUCTURE THE CNGS EXPERIENCE

    E-Print Network [OSTI]

    McDonald, Kirk

    of Aluminum Water cooled Current: 150kA (horn) ­ 180 kA (reflector) Pulse duration 7ms #12;Key elements Remote handling Remote station for radiation survey in the target chamber #12;CNGS Target Area I per cooling circuit 2007 run radiation effects on ventilation system electronics broken flexible stripline

  19. THE ROTATING TARGET FLOW TEST FACILITY

    E-Print Network [OSTI]

    McDonald, Kirk

    @idom.com) Fernando Sordo, ESS Bilbao Tom McManamy, ORNL/SNS #12;Status of the RTFT 4th HPTW of a RotaAng Target for ESS · In 2009 ESS Bilbao worked out a preliminary design for a rotaZng target for ESS. · Disc formed by un-clad tungsten bricks cooled

  20. Target Options for a Neutrino Factory

    E-Print Network [OSTI]

    McDonald, Kirk

    shield WC 6. Target station engineering Target integration Remote maintenance Shielding 7. Beam dump 7a possible/preferable? · Can the beam size be increased (from 1.2 mm (rms) baseline)? #12;Heat loads ­ Heating and material damage Issues ­ Heat load from 4 MW pulsed proton beam · Total Heat load