Sample records for targeted drug delivery

  1. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

    2012-08-28T23:59:59.000Z

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  2. Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery

    E-Print Network [OSTI]

    Tan, Mei Chee

    The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ...

  3. Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes

    E-Print Network [OSTI]

    Chau, Ying

    2005-01-01T23:59:59.000Z

    We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

  4. MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells

    E-Print Network [OSTI]

    Gao, Jinming

    MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells Jagadeesh Setti micelle (MFM) system that is encoded with a lung cancer-targeting peptide (LCP), and encapsulated. The LCP-encoded MFM showed significantly increased Rv 6-dependent cell targeting in H2009 lung cancer

  5. Drug delivery Combinatorial Drug Conjugation Enables Nanoparticle

    E-Print Network [OSTI]

    Zhang, Liangfang

    Drug delivery Combinatorial Drug Conjugation Enables Nanoparticle Dual-Drug Delivery Santosh Aryal, Che-Ming Jack Hu, and Liangfang Zhang* A new approach to loading multiple drugs onto the same drug through hydrolyzable linkers to form drug conjugates, is reported. In contrast to loading individual types

  6. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2011-04-28T23:59:59.000Z

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  7. Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme

    E-Print Network [OSTI]

    Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

    2006-01-01T23:59:59.000Z

    Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

  8. Drug Delivery DOI: 10.1002/anie.200802260

    E-Print Network [OSTI]

    Zare, Richard N.

    Drug Delivery DOI: 10.1002/anie.200802260 Sustained Release of Drugs Dispersed in Polymer) was observed for up to 40 days with up to 90% drug recovery. In vivo bioluminescence imaging of transgenic mice, represents a new drug delivery approach with great potential, particularly if particles can be targeted

  9. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01T23:59:59.000Z

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  10. Packaging for a drug delivery microelectromechanical system

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2005-01-01T23:59:59.000Z

    Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

  11. Communications Drug Delivery

    E-Print Network [OSTI]

    Tan, Weihong

    ] Further, the strategy based on targeting a specific binding site is impeded by the heterogeneity of tumors exhibit pH values between 6.15 and 7.40 (the latter value representing the mean pH value of arterial blood of these polymeric nanoparticle systems is time-consuming and requires a technical knowledge of synthesis. Recently

  12. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01T23:59:59.000Z

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  13. Drug delivery Preparation of Monodisperse Biodegradable Polymer

    E-Print Network [OSTI]

    Prentiss, Mara

    Drug delivery Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow-Focusing Device for Controlled Drug Delivery Qiaobing Xu, Michinao Hashimoto, Tram T. Dang, Todd microparticles have broad utility as vehicles for drug delivery and form the basis of several therapies approved

  14. Nanoparticle drug delivery enhances the cytotoxicity of hydrophobichydrophilic drug conjugates

    E-Print Network [OSTI]

    Zhang, Liangfang

    Nanoparticle drug delivery enhances the cytotoxicity of hydrophobic­hydrophilic drug conjugates, Accepted 4th October 2011 DOI: 10.1039/c1jm13834k We report a drug conjugation approach to concurrently load both hydrophobic and hydrophilic drugs into the same drug delivery nanocarrier in a precisely

  15. Abstract --This paper studies the use of the innovative concept of MRI-targeted drug delivery platform for robotic

    E-Print Network [OSTI]

    Mavroidis, Constantinos

    platform for robotic targeting of magnetized aerosol in the lungs. The goal is to increase dramatically presence in healthy lung tissues. For this purpose, a parametric analysis is conducted to specify the magnetic forces required to efficiently target magnetized liposomal agents to the lungs. The force

  16. Apoferritin-based nanomedicine platform for drug delivery: equilibrium...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA. Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study...

  17. Drug delivery by organ-specific immunoliposomes

    SciTech Connect (OSTI)

    Maruyama, Kazuo; Mori, Atsuhide; Hunag, Leaf (Tennessee Univ., Knoxville, TN (USA). Dept. of Biochemistry); Kennel, S.J. (Oak Ridge National Lab., TN (USA))

    1990-01-01T23:59:59.000Z

    Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside GM{sub 1} to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed. 25 refs., 5 figs.

  18. Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang,

    E-Print Network [OSTI]

    Zhang, Liangfang

    functionalization of the polymeric NPs with the A10 2 -fluoropyrimidine ribonucleic acid (RNA) aptamers nanoparticles, polymer conjugation chemistry, targeted drug delivery, sur- face functionalization, aptamersChapter 11 Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang

  19. Functionalized Zirconium Phosphate Nano Platelets - From Surface Design to Drug Delivery 

    E-Print Network [OSTI]

    Mukherjee, Atashi

    2014-05-30T23:59:59.000Z

    the intended target or compartment. This dissertation will focus on the analytical characterization of zirconium phosphate (ZrP) in both alpha and theta phases as a drug delivery matrix utilizing multiple unique and novel analytical techniques. In the first...

  20. Protein-Based Nanomedicine Platforms for Drug Delivery

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

    2009-08-03T23:59:59.000Z

    Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drug’s efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

  1. A resorbable polymeric microreservoir device for controlled release drug delivery

    E-Print Network [OSTI]

    Grayson, Amy Catherine Richards, 1975-

    2003-01-01T23:59:59.000Z

    The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

  2. Computer-Aided Drug Target Search

    E-Print Network [OSTI]

    Chen, Yuzong

    Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ...

  3. Transdermal microconduits by microscission for drug delivery and sample acquisition

    E-Print Network [OSTI]

    Gonzalez, Salvador

    Background Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...

  4. Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device

    E-Print Network [OSTI]

    Ho Duc, Hong Linh, 1978-

    2009-01-01T23:59:59.000Z

    An implantable rapid drug delivery device based on micro-electro-mechanical systems (MEMS) technology was designed, fabricated and validated for the in vivo rapid delivery of vasopressin in a rabbit model. In vitro ...

  5. Advances in Lymphatic Imaging and Drug Delivery

    SciTech Connect (OSTI)

    Nune, Satish K.; Gunda, Padmaja; Majeti, Bharat K.; Thallapally, Praveen K.; Laird, Forrest M.

    2011-09-10T23:59:59.000Z

    Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases will have invaded the lymphatic system as a first step in their progression. Hence, proper evaluation of the disease state of the lymphatics which drain a tumor site is crucial to staging and the formation of a treatment plan. Current lymphatic imaging modalities with visible dyes and radionucleotide tracers offer limited sensitivity and poor resolution; however, newer tools using nanocarriers, quantum dots, and magnetic resonance imaging promise to vastly improve the staging of lymphatic spread without needless biopsies. Concurrent with the improvement of lymphatic imaging agents, has been the development of drug carriers that can localize chemotherapy to the lymphatic system, thus improving the treatment of localized disease while minimizing the exposure of healthy organs to cytotoxic drugs. This review will focus on polymeric systems that have been developed for imaging and drug delivery to the lymph system, how these new devices improve upon current technologies, and where further improvement is needed.

  6. Chemical signatures and new drug targets for gametocytocidal drug

    E-Print Network [OSTI]

    Arnold, Jonathan

    Chemical signatures and new drug targets for gametocytocidal drug development Wei Sun1 *, Takeshi Q antimalarial drugs are not active against P. falciparum gametocytes, responsible for the spread of malaria screening 5,215 known drugs and compounds. All these compounds were active against three strains

  7. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

    E-Print Network [OSTI]

    Carlyle, Wenda C.

    Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug ...

  8. Needle-free drug delivery using shock wave techniques

    E-Print Network [OSTI]

    Pavlov, Atanas (Atanas Ivanov)

    2006-01-01T23:59:59.000Z

    A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

  9. A fully implantable intracochlear drug delivery device : development and characterization

    E-Print Network [OSTI]

    Swan, Erin Eileen Leary, 1976-

    2009-01-01T23:59:59.000Z

    In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

  10. Noninvasive quantification of drug delivery from an implantable MEMS device

    E-Print Network [OSTI]

    Johnson, Audrey M., 1976-

    2005-01-01T23:59:59.000Z

    (cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

  11. Microcapsule drug delivery device for treatment of glioblastoma multiforme

    E-Print Network [OSTI]

    Scott, Alexander Wesley

    2010-01-01T23:59:59.000Z

    Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. ...

  12. Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

    E-Print Network [OSTI]

    Tong, Rong

    We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, ...

  13. Drug delivery Sustained Drug Release from Non-eroding Nanoporous

    E-Print Network [OSTI]

    Sridhar, Srinivas

    drug, doxorubicin (Dox), from different non-eroding nanopor- ous coatings. Detailed studies of drug, in the case of small molecules such as Dox, enzymes would not interfere with the drug and hence the elution

  14. Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery

    E-Print Network [OSTI]

    Bhatia, Sangeeta

    Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery By Ji nanoparticles and drug molecules can be co- encapsulated in liposomes to simultaneously perform multiple and luminescent porous silicon nanoparticles to overcome such problems,[5,6] although these more complicated

  15. Pulsatile Drug Delivery System Based on Electrohydrodynamic Method

    E-Print Network [OSTI]

    Zheng, Yi; Hu, Junqiang; Gao, Wenle

    2012-01-01T23:59:59.000Z

    Electrohydrodynamic (EHD) generation, a commonly used method in BioMEMS, plays a significant role in the pulsatile drug delivery system for a decade. In this paper, an EHD based drug delivery system is well designed, which can be used to generate a single drug droplet as small as 2.83 nL in 8.5 ms with a total device of 2\\times2\\times3 mm^3, and an external supplied voltage of 1500 V. Theoretically, we derive the expressions for the size and the formation time of a droplet generated by EHD method, while taking into account the drug supply rate, properties of liquid, gap between two electrodes, nozzle size, and charged droplet neutralization. This work proves a repeatable, stable and controllable droplet generation and delivery system based on EHD method experimentally as well as theoretically.

  16. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  17. Novel polyoxazolines polymer drug delivery platform

    E-Print Network [OSTI]

    performed with 4 different polymers in multi- drug resistant (MCF7/ADR) human adenocarcinoma cells, non-resistant (MCF7) human adenocarcinoma cells and Madin-Darby canine kidney (MDCK) cells. All polymers were found lines. 2. To investigate the effect of the addition of drugs to the polymers on cell toxicity, micelles

  18. Computational model of local intravascular drug delivery

    E-Print Network [OSTI]

    Balakrishnan, Brinda

    2007-01-01T23:59:59.000Z

    Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

  19. Transdermal drug delivery by localized intervention

    E-Print Network [OSTI]

    Weaver, James C.

    Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free ...

  20. Acute Myeloid Leukemia: Nanomedicine drug delivery system could improve chemotherapy

    E-Print Network [OSTI]

    Pfeifer, Holger

    Acute Myeloid Leukemia: Nanomedicine drug delivery system could improve chemotherapy Chemotherapy is still the backbone of today's cancer treatment. This is exemplified by acute myeloid leukemia (AML generation anti-leukemia treatments. The results have been published in the Journal of Advanced Healthcare

  1. IFE Target Fabrication, Delivery, and Cost Estimates

    E-Print Network [OSTI]

    synergism but key differences that lead to specific technologies Heavy Ion Fusion Laser Fusion Z-Pinch IFE of this talk....... 1. IFE target technology builds upon the larger ICF program - Not starting from "zero" for IFE - Large effort for NIC fosters efficiency (e.g., foam shells) 2. The recent IFE target technology

  2. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)

    1993-01-01T23:59:59.000Z

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  3. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02T23:59:59.000Z

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  4. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu [ORNL] [ORNL; Warren, Kaitlyn E [ORNL] [ORNL; Naskar, Amit K [ORNL] [ORNL

    2014-01-01T23:59:59.000Z

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  5. Modeling oxaliplatin drug delivery to circadian rhythms in drug metabolism and host tolerance

    E-Print Network [OSTI]

    Clairambault, Jean

    period) time-scheduled regimens for cytotoxic drug delivery by intravenous infusion, a pharmacokinetic constant infusion of the same daily dose, when the biological time of peak infusion is correctly chosen. Furthermore, it is well adapted to using mathematical optimization methods of drug infusion flow, choosing

  6. Alendronate functionalized mesoporous hydroxyapatite nanoparticles for drug delivery

    SciTech Connect (OSTI)

    Li, Dongdong, E-mail: lidongchem@sina.cn [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China); Zhu, Yuntao; Liang, Zhiqiang [State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012 (China)

    2013-06-01T23:59:59.000Z

    Highlights: ? The synthesized mesoporous hydroxyapatite has nanostructure and bioactivity. ? The materials have high surface area and amino group. ? The materials show higher drug loading and slower release rate than pure HAP. - Abstract: Mesoporous nanosized hydroxyapatite (HAP) functionalized by alendronate (ALN) was synthesized using cationic surfactant CTAB as template. The structural, morphological and textural properties were fully characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and N{sub 2} adsorption/desorption. Then the obtained materials were performed as drug delivery carriers using ibuprofen (IBU) as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). The materials showed relatively slower release rate compared with HAP due to the ionic interaction between -NH{sub 3}{sup +} on the matrix and -COO{sup ?}belongs to IBU. The system provides a new concept for improving the drug loading or slowing down the release rate.

  7. 1. Introduction 2. Apicoplast as a drug target

    E-Print Network [OSTI]

    McFadden, Geoff

    1. Introduction 2. Apicoplast as a drug target 3. Conclusion 4. Expert opinion Review Targeting an excellent drug target. Areas covered: This review focuses on the biological role of the apicoplast in the erythrocytic life cycle and what that reveals about existing drug targets. We also discuss the future

  8. Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes

    E-Print Network [OSTI]

    Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes Ahmet Ali Yanik the effective analyte transport. To overcome this limitation, we propose and demonstrate a nanoplasmonic-nanofluidic layers of microfluidic channels through plasmonic/nanofluidic holes. To implement the proposed sensor

  9. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  10. Towards engineering hormone-binding globulins as drug delivery agents

    E-Print Network [OSTI]

    Chan, Wee Lee; Zhou, Aiwu; Read, Randy J.

    2014-11-26T23:59:59.000Z

    in optical thickness of the sensor tip. Cortisol was immobilised on the biosensor tip surface by forming an adduct of hydrocortisone 21-hemisuccinate and a pentylamine-biotin linker through an amide bond, then allowing the biotin moiety on this cortisol... adduct to bind to the streptavidin-conjugated biosensor tip. The cortisol- Towards Engineering Hormone-Binding Globulins as Drug Delivery Agents PLOS ONE | DOI:10.1371/journal.pone.0113402 November 26, 2014 4 / 21 conjugated sensors were immersed...

  11. Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications

    E-Print Network [OSTI]

    Edward, Jonathan M. (Jonathan Mark)

    2008-01-01T23:59:59.000Z

    Thermal and magnetically sensitive polymers are a new class of materials with unique properties suitable for applications in drug delivery. Specifically, these polymers can be combined with a drug reservoir to make a drug ...

  12. Photodynamic Therapy of the Canine Prostate: Intra-arterial Drug Delivery

    SciTech Connect (OSTI)

    Moore, Ronald B. [University of Alberta, Department of Surgery (Canada)], E-mail: rmoore@cha.ab.ca; Xiao, Zhengwen [University of Alberta, Cross Cancer Institute, Department of Oncology (Canada); Owen, Richard J.; Ashforth, Robert [University of Alberta, Department of Radiology and Diagnostic Imaging (Canada); Dickey, Dwayne [University of Alberta, Department of Electric Engineering (Canada); Helps, Cathy [Cross Cancer Institute, Department of Nuclear Medicine and Oncologic Imaging (Canada); Tulip, John [University of Alberta, Department of Electric Engineering (Canada)

    2008-01-15T23:59:59.000Z

    Purpose. Interstitial photodynamic therapy (PDT) selectively destroys tissue targeted with a photosensitizer and then exposed to light of a specific wavelength. We report a novel delivery method-intra-arterial drug delivery for PDT of the prostate-in a canine model.Methods. To evaluate drug distribution, the prostatovesical artery was selectively cannulated and photosensitizers alone or in conjunction with 99m-technetium-labeled macro-aggregated albumin ({sup 99m}Tc-MAA) were injected via a 3 Fr microcatheter in 8 animals. One dog was followed for 3 months to determine tolerance and toxicity. The remaining animals were euthanized and imaged with whole-body single photon emission CT and gamma counting for radioactivity distribution. Photosensitizer distribution was further analyzed by fluorescence confocal microscopy and tissue chemical extraction. To evaluate PDT, the photosensitizer QLT0074 was infused in 3 animals followed by interstitial illumination with 690 nm laser light. Results. Intra-arterial infusion selectively delivered drugs to the prostate, with both radioactivity and photosensitizer levels significantly higher (up to 18 times) than in the surrounding organs (i.e., rectum). With unilateral injection of {sup 99m}Tc-MAA, only the injected half of the prostate showed activity whereas bilateral administration resulted in drug delivery to the entire prostate. PDT resulted in comprehensive damage to the prostate without severe complications or systemic toxicity. Conclusion. Injection of radiolabeled MAA into the prostatovesical artery results in distribution within the prostate with negligible amounts reaching the adjacent organs. PDT also demonstrates selective damage to the prostate, which warrants clinical application in targeted prostate therapies.

  13. 1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds

    E-Print Network [OSTI]

    Marchiori, Elena

    1 INTRODUCTION 1 Predicting drug-target interactions for new drug compounds using a weighted@cs.ru.nl,elenam@cs.ru.nl Abstract In silico discovery of interactions between drug compounds and target proteins is of core importance for improving the efficiency of the laborious and costly experimental determination of drug

  14. Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic

    E-Print Network [OSTI]

    Getoor, Lise

    Drug-Target Interaction Prediction for Drug Repurposing with Probabilistic Similarity Logic Shobeir, USA getoor@cs.umd.edu ABSTRACT The high development cost and low success rate of drug dis- covery from appro- ved drugs. Computational methods can be effective in focu- sing efforts for such drug repurposing

  15. Computational Method for Drug Target Search and Application in Drug Discovery

    E-Print Network [OSTI]

    Chen, Yuzong

    Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ...

  16. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  17. A Key Target for Diabetes Drugs | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor,...

  18. Thermo-responsive Layer-by-Layer Assemblies for Nanoparticle-based Drug Delivery

    E-Print Network [OSTI]

    Zhou, Jing

    2013-11-26T23:59:59.000Z

    release in response to temperature is still challenging. Here, a thermo-responsive drug delivery system of solid dexamethasone nanoparticles (DXM NPs) encapsulated in a model LbL assembly of strong polyelectrolytes poly (diallyldimethylammonium chloride...

  19. Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device

    E-Print Network [OSTI]

    Li, Yawen, 1972-

    2005-01-01T23:59:59.000Z

    The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release ...

  20. Application of microfluidic emulsion technology to biochemistry, drug delivery and Lab-on-a-Chip programmability

    E-Print Network [OSTI]

    Urbanski, John Paul

    2005-01-01T23:59:59.000Z

    This research applies microfluidic emulsion technology to three diverse problems; biochemistry, drug delivery and lab-on-a-chip programmability. These subjects represent distinct research programs, but the underlying physics ...

  1. SIXTEENTH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN DRUG

    E-Print Network [OSTI]

    Tipple, Brett

    SIXTEENTH INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN DRUG DELIVERY SYSTEMS Register on-line: www on Recent Advances in Drug Delivery Systems "Drug Delivery: the penetrating challenges" Pioneering event in the field New drug targeting methods Improved delivery strategies Imaging and treatment combinations

  2. Exploring Polymer and Liposomal Carriers for Optimized Drug Delivery

    E-Print Network [OSTI]

    Ferguson, Heidi M

    2012-01-01T23:59:59.000Z

    1459–1467. Fox, M. E. Dendritic polymers for the delivery ofiii Chapter 1: Introduction to Polymer and Liposome Drugbioavailability. Conclusions Polymers and liposomes can be

  3. Optimal control of drug delivery to brain tumors for a PDE driven model using the Galerkin finite element method

    E-Print Network [OSTI]

    Hanson, Floyd B.

    Optimal control of drug delivery to brain tumors for a PDE driven model using the Galerkin finite is used to examine the optimal drug delivery to brain tumors. The PDE driven mathematical model and the drug concentration. An optimal control problem is formulated keeping in mind the primary goals

  4. Specific and general binding in arterial drug delivery

    E-Print Network [OSTI]

    Levin, Andrew D. (Andrew David), 1976-

    2005-01-01T23:59:59.000Z

    Drug-eluting stents have emerged as the most effective method for treating restenosis following percutaneous coronary interventions. This thesis investigates how drugs with similar physiochemical properties but different ...

  5. Toward a drug delivery coating for intraocular lenses

    E-Print Network [OSTI]

    Smith, Renée Chivon

    2010-01-01T23:59:59.000Z

    Layer-by-layer assembly has become a quintessential tool for the creation of versatile, dynamic nanostructured materials able to dictate cellular behavior through exquisite surface functionality and delivery of bioactive ...

  6. Quantification of Mesenchymal Stem Cell (MSC) Delivery to a Target Site Using In Vivo Confocal Microscopy

    E-Print Network [OSTI]

    Mortensen, Luke J.

    The ability to deliver cells to appropriate target tissues is a prerequisite for successful cell-based therapy. To optimize cell therapy it is therefore necessary to develop a robust method of in vivo cell delivery ...

  7. A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

    E-Print Network [OSTI]

    Liu, David V.

    Protein-based methods of targeted short-interfering RNA (siRNA) delivery have the potential to solve some of the problems faced by nanoparticle-based methods, such as poor pharmacokinetics and biodistribution, low tumor ...

  8. Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.; Jacobs, Damon T.; Forrest, M. Laird; Krise, Jeffrey P.

    2010-09-09T23:59:59.000Z

    previously described a concept for a novel drug delivery platform that relies on the propensity of drugs with optimal physicochemical properties to distribute differently in normal versus cancer cells due to differences in intracellular pH gradients...

  9. Targeted Drug Delivery To Leukocytes with ICAM-1 Derived Peptides

    E-Print Network [OSTI]

    Majumdar, Sumit

    2008-07-15T23:59:59.000Z

    cells by receptor mediated endocytosis and passive diffusion, respectively. High hydrophobicity of DOX-cIBR was proposed to be responsible for its energy-independent entry (chapter 2). To check the effect of hydrophobicity on internalization, two...

  10. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System 

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16T23:59:59.000Z

    Page 1 Chemical structure of paclitaxel; reproduced and cited ............................. 2 2 Schematic of the layer by layer (LbL) procedure....................................... 6 3 Chemical structures of chitosan and dextran... of the PAA solution was close to its pKa at 4.5. Ionic strength in the deposition and washing solutions also increased the thickness of PAA/PAH coatings.15 Figure 2. Schematic of the LbL procedure. Besides the electrostatic interactions, other...

  11. Progress toward a Colon Targeting Nanoparticle Based Drug Delivery System

    E-Print Network [OSTI]

    Yu, Xiao

    2012-07-16T23:59:59.000Z

    +/- 10 nm were fabricated, characterized and then encapsulated in synthetic / biomacromolecule shell chitosan, dextran-sulfate using a layer by layer (LbL) self-assembly technique. Surface modifications were performed by covalently conjugating with poly...

  12. Near-infrared-actuated devices for remotely controlled drug delivery

    E-Print Network [OSTI]

    Timko, Brian P.

    A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage ...

  13. Biocompatibility of an implantable ophthalmic drug delivery device

    E-Print Network [OSTI]

    Cohen, Sarah J. (Sarah Jennifer)

    2007-01-01T23:59:59.000Z

    Diseases of the posterior eye present clinicians with a treatment challenge mainly due to the region's inaccessible location. Several drugs, including those available for the treatment of exudative age-related macular ...

  14. Targeted and stimuli-responsive polymers as chemotherapeutic delivery systems

    E-Print Network [OSTI]

    Zaman, Noreen Tasneem

    2008-01-01T23:59:59.000Z

    Successful administration of chemotherapeutic agents for cancer treatment requires a balance between the efficacy and the safety of the drug. This often limits physicians to a very narrow therapeutic window. To avoid the ...

  15. Protein engineering for targeted delivery of radionuclides to tumors

    E-Print Network [OSTI]

    Orcutt, Kelly Davis

    2010-01-01T23:59:59.000Z

    Traditional cancer treatment strategies include systemic chemotherapy, external beam radiation, and surgical excision. Chemotherapy is nonspecific, and targets all rapidly dividing cells. External beam radiation and surgery ...

  16. Multiple-robot drug delivery strategy through coordinated teams of microswimmers

    SciTech Connect (OSTI)

    Kei Cheang, U; Kim, Min Jun, E-mail: mkim@coe.drexel.edu [Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania 19104 (United States); Lee, Kyoungwoo [Department of Computer Science, Yonsei University, Seoul 120-749 (Korea, Republic of); Julius, Anak Agung [Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)

    2014-08-25T23:59:59.000Z

    Untethered robotic microswimmers are very promising to significantly improve various types of minimally invasive surgeries by offering high accuracy at extremely small scales. A prime example is drug delivery, for which a large number of microswimmers is required to deliver sufficient dosages to target sites. For this reason, the controllability of groups of microswimmers is essential. In this paper, we demonstrate simultaneous control of multiple geometrically similar but magnetically different microswimmers using a single global rotating magnetic field. By exploiting the differences in their magnetic properties, we triggered different swimming behaviors from the microswimmers by controlling the frequency and the strength of the global field, for example, one swim and the other does not while exposed to the same control input. Our results show that the balance between the applied magnetic torque and the hydrodynamic torque can be exploited for simultaneous control of two microswimmers to swim in opposite directions, with different velocities, and with similar velocities. This work will serve to establish important concepts for future developments of control systems to manipulate multiple magnetically actuated microswimmers and a step towards using swarms of microswimmers as viable workforces for complex operations.

  17. IN-PLANE BANDPASS REGULATION CHECK VALVE IN HEAT-SHRINK PACKAGING FOR DRUG DELIVERY

    E-Print Network [OSTI]

    Meng, Ellis

    IN-PLANE BANDPASS REGULATION CHECK VALVE IN HEAT-SHRINK PACKAGING FOR DRUG DELIVERY R. Lo and E. Meng University of Southern California, Los Angeles, California, USA ABSTRACT The first check valve valve design and these results were confirmed experimentally. The valve regulates flow between 150

  18. BULK TITANIUM MICRONEEDLES WITH EMBEDDED MICROFLUIDIC NETWORKS FOR TRANSDERMAL DRUG DELIVERY

    E-Print Network [OSTI]

    MacDonald, Noel C.

    BULK TITANIUM MICRONEEDLES WITH EMBEDDED MICROFLUIDIC NETWORKS FOR TRANSDERMAL DRUG DELIVERY E. R micromachining of titanium for MEMS applications. Biomedical microsystems in particular can benefit from the high fracture toughness and biocompatibility associated with titanium. This paper reports on the design

  19. Microfabrication-Compatible Nanoporous Gold Foams as Biomaterials for Drug Delivery

    E-Print Network [OSTI]

    Seker, Erkin

    Microfabrication-Compatible Nanoporous Gold Foams as Biomaterials for Drug Delivery Erkin Seker different samples: (i) 12 mm-diameter circular plain glass cover slips; (ii) 5 mm-diameter gold spots patterned on the glass cover slips; (iii) 5 mm-diameter np-Au spots patterned on the glass cover slips

  20. DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL DATA

    E-Print Network [OSTI]

    Zeng, Jianyang "Michael"

    DRUG-TARGET INTERACTION PREDICTION BY INTEGRATING CHEMICAL, GENOMIC, FUNCTIONAL AND PHARMACOLOGICAL.edu.cn Corresponding author In silico prediction of unknown drug-target interactions (DTIs) has become a popular tool for drug repositioning and drug development. A key challenge in DTI prediction lies in integrating multiple

  1. Oral Drug Absorption

    E-Print Network [OSTI]

    Yamashita, Shinji

    2006-10-26T23:59:59.000Z

    properties ? membrane permeability ? metabolic stability ? enzyme inhibition or induction ? protein binding ? transporter affinity ?. Chemical Optimization DDS technology 4 Strategy of Drug Delivery Absorption Distribution Metabolism Excretion Improve of drug... absorption absorption enhancement controlled releasecontrolled release new administration route Drug targeting to the tissue to the cell to the organelle Dr. Shinji Yamashita (Setsunan University) Issue: Oral Drug Absorption Dr. Valentino J. Stella...

  2. Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient

    E-Print Network [OSTI]

    Hinow, Peter

    Summary Matrix tablets are drug delivery devices that release a water-soluble drug over an extended period of time. Such matrix tablets are formulated from mixtures of drug, polymer, and excipient powders variation in the drug release profile of the tablet. While fabrication of experimental tablets

  3. Fabrication methods and performance of low-permeability microfluidic components for a miniaturized wearable drug delivery system

    E-Print Network [OSTI]

    Mescher, Mark J.

    In this paper, we describe low-permeability components of a microfluidic drug delivery system fabricated with versatile micromilling and lamination techniques. The fabrication process uses laminate sheets which are machined ...

  4. Kilogram Scale Synthesis of a Triazine-based Dendrimer and the Development of a General Strategy for the Installation of Pharmacophores to Yield Potential Drug Delivery Agents

    E-Print Network [OSTI]

    Venditto, Vincent J.

    2011-02-22T23:59:59.000Z

    investigated for macromolecular drug delivery. Upon acylation of each drug with BOC-isonipecotic acid, substitution on the dendrimer may occur with varying levels of success depending on the drug in question. Upon successful substitution to afford the desired...

  5. Alveolar targeting of aerosol pentamidine. Toward a rational delivery system

    SciTech Connect (OSTI)

    Simonds, A.K.; Newman, S.P.; Johnson, M.A.; Talaee, N.; Lee, C.A.; Clarke, S.W. (Royal Free Hospital, London (England))

    1990-04-01T23:59:59.000Z

    Nebulizer systems that deposit a high proportion of aerosolized pentamidine on large airways are likely to be associated with marked adverse side effects, which may lead to premature cessation of treatment. We have measured alveolar deposition and large airway-related side effects (e.g., cough, breathlessness, and effect on pulmonary function) after aerosolization of 150 mg pentamidine isethionate labeled with {sup 99m}Tc-Sn-colloid. Nine patients with AIDS were studied using three nebulizer systems producing different droplet size profiles: the Acorn System 22, Respirgard II, and Respirgard II with the inspiratory baffle removed. Alveolar deposition was greatest and side effects least with the nebulizer producing the smallest droplet size profile (Respirgard II), whereas large airway-related side effects were prominent and alveolar deposition lowest with the nebulizer producing the largest droplet size (Acorn System 22). Values for alveolar deposition and adverse airway effects were intermediate using the Respirgard with inspiratory baffle removed, thus indicating the importance of the baffle valve in determining droplet size. Addition of a similar baffle valve to the Acorn System 22 produced a marked improvement in droplet size profile. Selection of a nebulizer that produces an optimal droplet size range offers the advantage of enhancing alveolar targeting of aerosolized pentamidine while reducing large airway-related side effects.

  6. In vitro evaluation of theranostic polymeric micelles for imaging and drug delivery in cancer Rajiv Kumar*, Apurva Kulkarni, Dattatri K Nagesha, Srinivas Sridhar

    E-Print Network [OSTI]

    Sridhar, Srinivas

    and controlled drug delivery. CdSe quantum dots (QDs) and anti-cancer drug, doxorubicin (Dox), were co absorbance and fluorescence features of QDs and Dox. TEM and DLS studies yielded a size of

  7. Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection

    SciTech Connect (OSTI)

    Daniela Rodica Radu

    2005-12-19T23:59:59.000Z

    The central theme of this dissertation is represented by the versatility of mesoporous silica nanomaterials in various applications such as catalysis and bio-applications, with main focus on biological applications of Mesoporous Silica Nanospheres (MSN). The metamorphosis that we impose to these materials from catalysis to sensing and to drug and gene delivery is detailed in this dissertation. First, we developed a synthetic method that can fine tune the amount of chemically accessible organic functional groups on the pores surface of MSN by exploiting electrostatic and size matching between the cationic alkylammonium head group of the cetyltrimethylammonium bromide (CTAB) surfactant and various anionic organoalkoxysilane precursors at the micelle-water interface in a base-catalyzed condensation reaction of silicate. Aiming nature imitation, we demonstrated the catalytic abilities of the MSNs, We utilized an ethylenediamine functional group for chelating Cu{sup 2+} as a catalytic functional group anchored inside the mesopores. Thus, a polyalkynylene-based conducting polymer (molecular wire) was synthesized within the Cu-functionalized MSNs silica catalyst. For sensing applications, we have synthesized a poly(lactic acid) coated mesoporous silica nanosphere (PLA-MSN) material that serves as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. We exploited the mesoporosity of MSNs for encapsulating pharmaceutical drugs. We examined bio-friendly capping molecules such as polyamidoamine dendrimers of generations G2 to G4, to prevent the drug leaching. Next, the drug delivery system employed MSNs loaded with Doxorubicin, an anticancer drug. The results demonstrated that these nano-Trojan horses have ability to deliver Doxorubicin to cancer cells and induce their death. Finally, to demonstrate the potential of MSN as an universal cellular transmembrane nanovehicle, we anchored positively charged dendrimers on the surface of MSN and utilize them to complex cationic DNA. The p-EGFP-CI gene-coated MSN nanocomposite was able to transfect cancer cell lines, such as human HeLa and CHO cancer cell lines. The gene carrier ability of MSNs was further proved by transfecting primary cells and cotransfecting of two different genes in cancer cell lines. In sum, MSN are versatile partners in several types of applications.

  8. In vivo real-time monitoring system of electroporation mediated control of transdermal and topical drug delivery

    E-Print Network [OSTI]

    Ljubljana, University of

    ), doxorubicin (DOX) or fentanyl (FEN), were applied to the skin before and after EP. The new monitoring system as a positive control. The non-invasive monitoring of the delivery of DOX, a fluorescent chemotherapeutic drug the observed effects as obtained with FD and DOX, by the measured physiological responses of the mice as well

  9. Local Delivery System of Immune Modulating Drug for Unresectable Adenocarcinoma: In Vitro Experimental Study and In Vivo Animal Study

    SciTech Connect (OSTI)

    Lee, Don Haeng [Inha University, College of Medicine, Department of Internal Medicine (Korea, Republic of); Kang, Sung-Gwon [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of)], E-mail: gangsg@radiol.snu.ac.kr; Jeong, Seok [Inha University, College of Medicine, Department of Internal Medicine (Korea, Republic of); Yoon, Chang Jin; Choi, Jung-Ah [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of); Byun, Ju Nam [Chosun University, College of Medicine, Department of Radiology (Korea, Republic of); Park, Jae Hyung [Seoul National University Bundang Hospital, Department of Diagnostic Radiology (Korea, Republic of); Lee, Kyu Back [Korea University, College of Medicine, Department of Biomedical Engineering (Korea, Republic of)

    2006-10-15T23:59:59.000Z

    The purpose of the study was to evaluate the efficacy and safety of a developed drug delivery system containing OK-432 through in vitro and animal study. An OK-432-impregnated polycarbonate/polyurethane stent membrane was used to develop a drug delivery system (DDS) enabling the locoregional release of OK-432. Polyethyleneglycol was used as a detergent and porosity generator. The stability of OK-432 in solvent, releasing kinetics of drug, and cytotoxicity of the DDS were evaluated. OK-432-impregnated DDS was implanted in mice in which a human adenocarcinoma cell line was injected and grown in their back. Flow cytometry and enzyme-linked immunosorbent assay were used for quantifying the amount of drug. OK-432 exposed to phosphate-buffered saline and OK-432 exposed to N,N-dimethylacetamide showed similar results on dot graphs and histograms. However, OK-432 exposed to tetrahydrofurane showed different dot graphs and histograms, which means that the antigenicity of the drug was changed. The release rate of OK-432 was maintained at a constant level for 6 weeks. The local delivery of OK-432 was found to have an antitumor effect on a human adenocarcinoma cell line in an animal study, but no effect on this cell line in in vitro cell culture. Histologic examination showed minimal inflammatory reaction in surrounding tissue. Our study shows that local treatment using this OK-432 release system is safe and effective in reducing adenocarcinoma in a mouse model.

  10. Hepatic Stellate Cell–Targeted Delivery of Hepatocyte Growth Factor Transgene via Bile Duct Infusion Enhances Its Expression at Fibrotic Foci to Regress Dimethylnitrosamine-Induced Liver Fibrosis

    E-Print Network [OSTI]

    Narmada, Balakrishnan Chakrapani

    Liver fibrosis generates fibrotic foci with abundant activated hepatic stellate cells and excessive collagen deposition juxtaposed with healthy regions. Targeted delivery of antifibrotic therapeutics to hepatic stellate ...

  11. REVIEWS Drug Discovery Today Volume 12, Numbers 1/2 January 2007 Drug-target identification in Drosophila

    E-Print Network [OSTI]

    Perrimon, Norbert

    the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery studies over the years has relied on the ease of growing this organism and the powerful genetic tools such as the insulin, epidermal growth factor, transforming growth factor b, Wnt, Hedgehog, JAK/STAT and Notch pathways

  12. Development of Novel Polymeric Materials for Gene Therapy and pH-Sensitive Drug Delivery: Modeling, Synthesis, Characterization, and Analysis

    SciTech Connect (OSTI)

    Brian Curtis Anderson

    2002-08-27T23:59:59.000Z

    The underlying theme of this thesis is the use of polymeric materials in bioapplications. Chapters 2-5 either develop a fundamental understanding of current materials used for bioapplications or establish protocols and procedures used in characterizing and synthesizing novel materials. In chapters 6 and 7 these principles and procedures are applied to the development of materials to be used for gene therapy and drug delivery. Chapter one is an introduction to the ideas that will be necessary to understand the subsequent chapters, as well as a literature review of these topics. Chapter two is a paper that has been published in the ''Journal of Controlled Release'' that examines the mechanism of drug release from a polymer gel, as well as experimental design suggestions for the evaluation of water soluble drug delivery systems. Chapter three is a paper that has been published in the ''Journal of Pharmaceutical Sciences'' that discusses the effect ionic salts have on properties of the polymer systems examined in chapter two. Chapter four is a paper published in the Materials Research Society Fall 2000 Symposium Series dealing with the design and synthesis of a pH-sensitive polymeric drug delivery device. Chapter five is a paper that has been published in the journal ''Biomaterials'' proposing a novel polymer/metal composite for use as a biomaterial in hip arthroplasty surgery. Chapter six is a paper that will appear in an upcoming volume of the Journal ''Biomaterials'' dealing with the synthesis of a novel water soluble cationic polymer with possible applications in non-viral gene therapy. Chapter seven is a paper that has been submitted to ''Macromolecules'' discussing several novel block copolymers based on poly(ethylene glycol) and poly(diethylamino ethyl methacrylate) that possess both pH-sensitive and temperature sensitive properties. Chapter eight contains a summary of the research contained in chapters 2-7 and proposes future research for the gene therapy and drug delivery projects.

  13. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool ofTopo II: An Enzyme Target for

  14. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool ofTopo II: An Enzyme Target forTopo II: An

  15. Optical instrument for measurement of vaginal coating thickness by drug delivery formulations

    SciTech Connect (OSTI)

    Henderson, Marcus H.; Peters, Jennifer J.; Walmer, David K.; Couchman, Grace M.; Katz, David F. [Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 (United States); Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina 27710 (United States); Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 and Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina 27710 (United States)

    2005-03-01T23:59:59.000Z

    An optical device has been developed for imaging the human vaginal epithelial surfaces, and quantitatively measuring distributions of coating thickness of drug delivery formulations - such as gels - applied for prophylaxis, contraception or therapy. The device consists of a rigid endoscope contained within a 27-mm-diam hollow, polished-transparent polycarbonate tube (150 mm long) with a hemispherical cap. Illumination is from a xenon arc. The device is inserted into, and remains stationary within the vagina. A custom gearing mechanism moves the endoscope relative to the tube, so that it views epithelial surfaces immediately apposing its outer surface (i.e., 150 mm long by 360 deg. azimuthal angle). Thus, with the tube fixed relative to the vagina, the endoscope sites local regions at distinct and measurable locations that span the vaginal epithelium. The returning light path is split between a video camera and photomultiplier. Excitation and emission filters in the light path enable measurement of fluorescence of the sited region. Thus, the instrument captures video images simultaneously with photometric measurement of fluorescence of each video field [{approx}10 mm diameter; formulations are labeled with 0.1% w/w United States Pharmacoepia (USP) injectable sodium fluorescein]. Position, time and fluorescence measurements are continuously displayed (on video) and recorded (to a computer database). The photomultiplier output is digitized to quantify fluorescence of the endoscope field of view. Quantification of the thickness of formulation coating of a surface sited by the device is achieved due to the linear relationship between thickness and fluorescence intensity for biologically relevant thin layers (of the order of 0.5 mm). Summary measures of coating have been developed, focusing upon extent, location and uniformity. The device has begun to be applied in human studies of model formulations for prophylaxis against infection with HIV and other sexually transmitted pathogens.

  16. Efficient drug delivery mechanisms of liposomes with tethered biopolymer brushes in aqueous solution using dissipative particle dynamics simulations

    E-Print Network [OSTI]

    Goicochea, A Gama; Klapp, J; Pastorino, C

    2013-01-01T23:59:59.000Z

    We undertake the investigation of model liposomes covered with polyethylene glycol brushes as a case study for the mechanisms of efficient drug delivery in biologically relevant situations.Extensive non- equilibrium, coarse grained dissipative particle dynamics simulations of polymer brushes of various lengths and shear rates are performed, having in mind polymer brushes covering the surfaces of drug carrying liposomes in the human circulatory system.In particular, we calculate the viscosity and the friction coefficient for polymer brushes as functions of the shear rate and polymerization degree under theta solvent conditions, and find that the liposome brushes experience considerable shear thinning at large shear rates. The viscosity is shown to obey a scaling law at high shear rate irrespective of the brushes degree of polymerization. A new general scaling relation is obtained for the viscosity at high shear rates. These results reproduce very well trends in recent drug delivering experiments.

  17. Liquid Hydrogen Delivery - Strategic Directions for Hydrogen...

    Broader source: Energy.gov (indexed) [DOE]

    Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

  18. drug discovery drug discovery

    E-Print Network [OSTI]

    drug discovery at Purdue #12;drug discovery 2 #12;drug discovery 3 Introduction The drug discovery and innovative drug candidates to treat chronic and acute illnesses. Our researchers also continue to be invested in various approaches to drug discovery, which include understanding of drug targets for future drug

  19. Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles

    SciTech Connect (OSTI)

    Lammert, M. P.; Burton, J.; Sindler, P.; Duran, A.

    2014-10-01T23:59:59.000Z

    This research project compares laboratory-measured fuel economy of a medium-duty diesel powered hydraulic hybrid vehicle drivetrain to both a conventional diesel drivetrain and a conventional gasoline drivetrain in a typical commercial parcel delivery application. Vehicles in this study included a model year 2012 Freightliner P100H hybrid compared to a 2012 conventional gasoline P100 and a 2012 conventional diesel parcel delivery van of similar specifications. Drive cycle analysis of 484 days of hybrid parcel delivery van commercial operation from multiple vehicles was used to select three standard laboratory drive cycles as well as to create a custom representative cycle. These four cycles encompass and bracket the range of real world in-use data observed in Baltimore United Parcel Service operations. The NY Composite cycle, the City Suburban Heavy Vehicle Cycle cycle, and the California Air Resources Board Heavy Heavy-Duty Diesel Truck (HHDDT) cycle as well as a custom Baltimore parcel delivery cycle were tested at the National Renewable Energy Laboratory's Renewable Fuels and Lubricants Laboratory. Fuel consumption was measured and analyzed for all three vehicles. Vehicle laboratory results are compared on the basis of fuel economy. The hydraulic hybrid parcel delivery van demonstrated 19%-52% better fuel economy than the conventional diesel parcel delivery van and 30%-56% better fuel economy than the conventional gasoline parcel delivery van on cycles other than the highway-oriented HHDDT cycle.

  20. Pharmaceutical Properties of Nanoparticulate Formulation Composed of TPGS and PLGA for Controlled Delivery of Anticancer Drug

    E-Print Network [OSTI]

    Mu, L.

    A suitable management of the pharmaceutical property is needed and helpful to design a desired nanoparticulate delivery system, which includes the carrier nature, particle size and size distribution, morphology, surfactant ...

  1. Synthesis and Characterization of Lipid-Polymer Hybrid Nanoparticles for Combinatorial Drug Delivery

    E-Print Network [OSTI]

    Stavropoulos, Kathy

    2011-08-31T23:59:59.000Z

    within the lipid monolayer to form a polyethylene glycol (PEG) corona [27]. The polymeric core affects drug encapsulation and release. Drug release from the nanoparticles begins with diffusion processes, followed by erosion, then swelling of the matrix... for preventing water-soluble drugs from leaking out of the core [29]. The corona affects biodistribution and circulation half-life. The PEG corona provides electrostatic and steric stabilization as well as a protective layer from adsorptive recognition proteins...

  2. Fabrication of complex oral drug delivery forms by Three Dimensional Printing (tm)

    E-Print Network [OSTI]

    Katstra, Wendy E. (Wendy Ellen), 1974-

    2001-01-01T23:59:59.000Z

    Three Dimensional Printing 3DPTM is a novel solid freeform fabrication technology that has been applied to the fabrication of complex pharmaceutical drug devices. Limitations of the technology as relating to pharmaceuticals ...

  3. Biopolymer-Connected Liposome Networks as Injectable Biomaterials Capable of Sustained Local Drug Delivery

    E-Print Network [OSTI]

    Raghavan, Srinivasa

    kinetics from liposome gels of a cationic anticancer drug doxorubicin (Dox) encapsulated in liposomes. Sustained release of Dox from these gels and the concomitant cytotoxic effect could be observed for over

  4. Functionalized Zirconium Phosphate Nano Platelets - From Surface Design to Drug Delivery

    E-Print Network [OSTI]

    Mukherjee, Atashi

    2014-05-30T23:59:59.000Z

    effective distribution (4) control pharmacokinetic and drug tissue distribution profile; (5) improve intracellular penetration.52 Some of the essential 1 5 characteristics that make up an effective nanocarrier include: (1) being made from...

  5. Side-Opening Hollow Microneedles for Transdermal Drug Delivery Wijaya Martanto1

    E-Print Network [OSTI]

    Arrays of hollow microneedles have been proposed to achieve painless injection and infusion of drug that serve as the microfluidic needle bores for injection or infusion, which terminate in side-opening holes

  6. A Model pH Induced Drug-Delivery System Based on Poly(methacrylic acid) and its Interpolymer complex

    E-Print Network [OSTI]

    Murugan, K Durai; Natarajan, P

    2015-01-01T23:59:59.000Z

    The dynamics and structural aspects of polymethacrylic acid bound rhodamine-123 (PMAA-R123) and its interpolymer complex with poly(vinylpyrrolidone) were investigated and the results show that these complexes have potential for use as drug-delivery system under physiological conditions. The time resolved fluorescence anisotropy decay of PMAA-R123 at different pH exhibits an associated anisotropy decay behavior characteristic of two different environments experienced by the fluorophore and decays with one shorter and another longer lifetime components. The anisotropy decay retains normal bi-exponential behavior under neutral pH. Fluorescence correlation spectroscopic investigation reveals that the attached fluorophore undergoes hydrolysis under basic condition which results in the release of the fluorophore from the polymer backbone. Shrinkage in the hydrodynamic radius of PMAA is observed on addition of the complementary polymer PVP which is attributed to the formation compact solubilised nanoparticle like ag...

  7. Computational Modeling of an MRI Guided Drug Delivery System Based on Magnetic Nanoparticle Aggregations for the Navigation of Paramagnetic Nanocapsules

    E-Print Network [OSTI]

    N. K. Lampropoulos; E. G. Karvelas; I. E. Sarris

    2015-04-14T23:59:59.000Z

    A computational method for magnetically guided drug delivery is presented and the results are compared for the aggregation process of magnetic particles within a fluid environment. The model is developed for the simulation of the aggregation patterns of magnetic nanoparticles under the influence of MRI magnetic coils. A novel approach for the calculation of the drag coefficient of aggregates is presented. The comparison against experimental and numerical results from the literature is showed that the proposed method predicts well the aggregations in respect to their size and pattern dependance, on the concentration and the strength of the magnetic field, as well as their velocity when particles are driven through the fluid by magnetic gradients.

  8. The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers http://www.bioportfolio.com/news/article/620380/The-Targeted-Delivery-Of-Multicomponent-Cargos-To-Cancer-Cells-By-Nanoporous-Particle.html[4/21/

    E-Print Network [OSTI]

    Brinker, C. Jeffrey

    and Conferences Corporate Events Gene Channels News Publish Report Store Resources Video Prostate Cancer Treatment Learn about innovative treatments for Prostate Cancer diagnosis today CancerThe targeted delivery of multicomponent cargos to cancer cells by nanoporous particle

  9. Molecular Analysis of Drug Delivery Systems Controlled by Dissolution of the Polymer Carrier

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    of the polymer carrier controls the drug release) have similar characteristics to many biodegrad- able systems. As Lee4 pointed out in his pioneering work in 1980, phase erosion-based systems include those in which involved. The model of Lee and Peppas13 predicts that the gel layer thickness is directly proportional

  10. DRUG DELIVERY IN BIOLOGICAL TISSUES: AN APPLICATION TO THE ELUTING STENT

    E-Print Network [OSTI]

    Pontrelli, Giuseppe

    [3]. The present work provides a fundamental study of the mass transfer process of a substance across range and it is recognized that the time and quantity of release of the drug is crucial for the therapy models predicting the dynamics of solute concentration and mass flux are of interest for biomedical

  11. Multiwaveguide implantable probe for light delivery to sets of distributed brain targets

    E-Print Network [OSTI]

    Zorzos, Anthony Nicholas

    Optical fibers are commonly inserted into living tissues such as the brain in order to deliver light to deep targets for neuroscientific and neuroengineering applications such as optogenetics, in which light is used to ...

  12. Current Drug Targets, 2007, 8, 15-30 15 1389-4501/07 $50.00+.00 2007 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    McFadden, Geoff

    Current Drug Targets, 2007, 8, 15-30 15 1389-4501/07 $50.00+.00 © 2007 Bentham Science Publishers Ltd. Fatty Acid Biosynthesis as a Drug Target in Apicomplexan Parasites C.D. Goodman* and G.I. Mc impacts on much of the world's population. The increasing prevalence of drug resistant parasites

  13. Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells

    E-Print Network [OSTI]

    Ndolo, Rosemary A.

    2012-08-31T23:59:59.000Z

    was found to induce marked tumor regression. The discovery of nitrogen mustard as a novel anticancer drug resulted in a great deal of optimism that cancer could finally be cured. A burst of research activity to develop new anticancer drugs therefore... of activity against normal cells. Indeed, many novel anticancer agents continue to be identified, but few find clinical utility due to unacceptable toxicity [17], a clear indicator that there is a need for a screening approach that can identify potent drugs...

  14. Structure-based drug mechanism study and inhibitor design targeting tuberculosis 

    E-Print Network [OSTI]

    Wang, Feng

    2009-05-15T23:59:59.000Z

    The increase of multi-drug resistant and extensively drug resistant tuberculosis (TB) cases makes it urgent to develop a new generation of TB drugs to counter resistance and shorten treatment. Structural biology, which ...

  15. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01T23:59:59.000Z

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

  16. A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy

    E-Print Network [OSTI]

    Valencia, Pedro M. (Pedro Miguel)

    2013-01-01T23:59:59.000Z

    The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

  17. Example 1: Bioenergetic analysis of combining mitochondria-targeted drugs with 2-deoxyglucose in breast cancer cells

    E-Print Network [OSTI]

    Example 1: Bioenergetic analysis of combining mitochondria-targeted drugs with 2- deoxyglucose in breast cancer cells OVERVIEW The MCW Cancer Center Bioenergetics Shared Resource opened in January 2012 in MFRC 2013. The purpose of the Bioenergetics Shared Resource is four- fold: investigate cancer cell

  18. UNCORRECTEDPROOF Please cite this article in press as: Arinaminpathy, Y. et al. Computational analysis of membrane proteins: the largest class of drug targets, Drug Discov Today (2009), doi:10.1016/

    E-Print Network [OSTI]

    Gerstein, Mark

    2009-01-01T23:59:59.000Z

    analysis of membrane proteins: the largest class of drug targets, Drug Discov Today (2009), doi:10.1016/ j.drudis.2009.08.006 Drug Discovery Today Volume 00, Number 00 September 2006 REVIEWS Computational analysis disorders, such as hypertension, congestive heart failure, stroke and cancer. On a similar scale, genetic

  19. Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion

    SciTech Connect (OSTI)

    Knobloch, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland); Portier, C.J. [Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 (United States); Levionnois, O.L. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Theurillat, R. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Thormann, W. [Department of Clinical Pharmacology, University of Bern, 3010 Bern (Switzerland); Spadavecchia, C. [Division Anesthesiology, Department of Clinical Veterinary Medicine, University of Bern 3012, Bern (Switzerland); Mevissen, M. [Division Veterinary Pharmacology and Toxicology, University of Bern, 3012 Bern (Switzerland)]. E-mail: meike.mevissen@vpi.unibe.ch

    2006-11-01T23:59:59.000Z

    Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

  20. Gaseous Hydrogen Delivery Breakout- Strategic Directions for Hydrogen Delivery Workshop

    Broader source: Energy.gov [DOE]

    Targets, barriers and research and development priorities for gaseous delivery of hydrogen through hydrogen and natural gas pipelines.

  1. Hydrogen Delivery Analysis Models

    Broader source: Energy.gov (indexed) [DOE]

    insert our Research Targets to see the impact List of Delivery Components Compressed Hydrogen Gas Truck (Tube trailer) Compressed Hydrogen Gas Truck Terminal Liquid Hydrogen Truck...

  2. seminar abstract Intradermal Delivery of Nanoparticle Vaccine Formulation via Microneedle

    E-Print Network [OSTI]

    Thomas, David D.

    and other strategies such as iontophoresis were developed to increase drug delivery efficiency.(Prausnitz

  3. Articulating feedstock delivery device

    DOE Patents [OSTI]

    Jordan, Kevin

    2013-11-05T23:59:59.000Z

    A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

  4. Hydrothermal synthesis and afterglow luminescence properties of hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres for potential application in drug delivery

    SciTech Connect (OSTI)

    Feng, Pengfei; Zhang, Jiachi, E-mail: zhangjch@lzu.edu.cn; Qin, Qingsong; Hu, Rui; Wang, Yuhua

    2014-02-01T23:59:59.000Z

    Highlights: • We designed a novel afterglow labeling material SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} for the first time. • Hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres with afterglow were prepared by hydrothermal method. • Hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} is a potential afterglow labeling medium for drug delivery. - Abstract: A novel afterglow labeling material SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} with hollow sphere shape and intense afterglow luminescence is prepared by hydrothermal method at 180 °C for the first time. The morphology and the sphere growth process of this material are investigated by scanning electron microscopy in detail. The afterglow measurement shows that this hydrothermal obtained material exhibits obvious red afterglow luminescence (550–700 nm) of Sm{sup 3+} which can last for 542 s (0.32 mcd/m{sup 2}). The depth of traps in this hydrothermal obtained material is calculated to be as shallow as 0.58 eV. The results demonstrate that although it is necessary to further improve the afterglow performance of the hydrothermal derived hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres, it still can be regarded as a potential afterglow labeling medium for drug delivery.

  5. Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs

    E-Print Network [OSTI]

    Tan, Weihong

    drugs (11, 12, 18­21). Nucleic acid aptamers are single-stranded oligonucleotides with unique intra cells (22­26). Re- cent biotechnological advancements have led to a variety of tar- geted drug transport blocks to construct sophisticated nucleic acid-based nanomaterials, or laborious and i

  6. Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery

    E-Print Network [OSTI]

    Vukmirovic, Neda

    2007-01-01T23:59:59.000Z

    Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

  7. antirheumatic drugs dmards: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  8. antineoplastic drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  9. antineoplastic drugs chimio-radiotherapie: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  10. In Vivo Monitoring of Tissue Pharmacokinetics of Liposome/Drug Using MRI: Illustration of Targeted

    E-Print Network [OSTI]

    if MnSO4/doxoru- bicin (DOX) loaded liposomes could be used for in vivo moni- toring of liposome concentration distributions as well as drug release by using a novel MnSO4-doxorubicin (DOX) formulation is used to load DOX (4). This method of loading uses the metal concentration gra- dient (4

  11. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: A persistence gene and protein drug target

    SciTech Connect (OSTI)

    Kantardjieff, K A; Vasquez, C; Castro, P; Warfel, N M; Rho, B; Lekin, T; Kim, C; Segelke, B W; Terwilliger, T C; Rupp, B

    2004-09-24T23:59:59.000Z

    The 1.9 {angstrom} native structure of pyrimidine biosynthesis regulatory protein encoded by the Mycobacterium tuberculosis pyrR gene (Rv1379) is reported. Because pyrimidine biosynthesis is an essential step in the progression of TB, pyrR is an attractive antitubercular drug target. The Mycobacterium tuberculosis pyrR gene (Rv1379) encodes a protein that regulates expression of pyrimidine nucleotide biosynthesis (pyr) genes in a UMP-dependent manner. Because pyrimidine biosynthesis is an essential step in the progression of TB, the gene product pyrR is an attractive antitubercular drug target. We report the 1.9 {angstrom} native structure of Mtb pyrR determined by the TB Structural Genomics Consortium facilities (PDB entry 1W30) in trigonal space group P3{sub 1}21, with cell dimensions at 120K of a = 66.64 {angstrom}, c = 154.72 {angstrom}, and two molecules in the asymmetric unit. The 3D structure and residual uracil phosphoribosyltransferase activity point to a common PRTase ancestor for pyrR. However, while PRPP and UMP binding sites have been retained in Mtb pyrR, a novel dimer interaction among subunits creates a deep, positively charged cleft capable of binding pyr mRNA. In silico screening of pyrimidine nucleoside analogs has revealed a number of potential leads compounds that, if bound to Mtb pyrR, could facilitate transcriptional attenuation, particularly cyclopentenyl nucleosides.

  12. Frontiers in Disease Therapies UCSB's integration of critical aspects of biological engineering (drug delivery, systems biology, biomateri-

    E-Print Network [OSTI]

    Akhmedov, Azer

    the many diseases that UCSB has cross-disciplinary efforts in, including cancer, diabetes, PTSD, Alzheimer targeting therapeutics to cancer cells while sparing healthy ones. In cancer and diabetes, another failure diabetic patients using closed-loop devices in clinical trials. For more insight into our approach

  13. Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design.

    E-Print Network [OSTI]

    Ah Young, AP; Koehl, A; Cascio, D; Egea, PF

    2015-01-01T23:59:59.000Z

    falciparum: Targeting protein folding and secretion forfalciparum: targeting protein folding and secretion for

  14. Fractalkine Targeting with a Receptor-Mimicking Peptide-Amphiphile

    E-Print Network [OSTI]

    Kokkoli, Efie

    . Kasinskas, Anastasia Mardilovich, and Ashish Garg Department of Chemical Engineering and Materials Science drug delivery systems driven by a strong need in clinical practice. Advances in materials science to the target tissue.2 Liposomes have been investigated extensively and long-circulating liposomes (stealth lipo

  15. Vaccine delivery with microneedle skin patches in nonhuman primates

    E-Print Network [OSTI]

    Li, Adrienne V

    Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics ...

  16. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release is controlled by polymer degradation

  17. Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable Polymer

    E-Print Network [OSTI]

    Yao, Y. Lawrence

    1 Effect of Drug Loading and Laser Surface Melting on Drug Release Profile from Biodegradable The biodegradable polymer such as poly(L-lactic acid) is promising in drug delivery applications because it allows for drug release in a controlled manner. In a polymer-based drug delivery system, drug release

  18. anti-tuberculosis drug ethionamide: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  19. anti-parkinsonian drug selegiline: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Information Sciences Websites Summary: delivery of safe and cost- effective patient care1. The incidence of drug-drug interactions (DDIsExtracting Drug-Drug Interaction...

  20. Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery...

    Broader source: Energy.gov (indexed) [DOE]

    Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop Targets, barriers and...

  1. An acoustically-driven biochip - Impact of flow on the cell-association of targeted drug carriers

    E-Print Network [OSTI]

    Fillafer, Christian; Neumann, Jürgen; Guttenberg, Zeno; Dissauer, Silke; Lichtscheidl, Irene; Wirth, Michael; Gabor, Franz; Schneider, Matthias; 10.1039/B906006E

    2011-01-01T23:59:59.000Z

    The interaction of targeted drug carriers with epithelial and endothelial barriers in vivo is largely determined by the dynamics of the body fluids. To simulate these conditions in binding assays, a fully biocompatible in vitro model was developed which can accurately mimic a wide range of physiological flow conditions on a thumbnail-format cell-chip. This acoustically-driven microfluidic system was used to study the interaction characteristics of protein-coated particles with cells. Poly(D,L-lactide-co-glycolide) (PLGA) microparticles (2.86 {\\pm} 0.95 {\\mu}m) were conjugated with wheat germ agglutinin (WGA-MP, cytoadhesive protein) or bovine serum albumin (BSA-MP, nonspecific protein) and their binding to epithelial cell monolayers was investigated under stationary and flow conditions. While mean numbers of 1500 {\\pm} 307 mm-2 WGA-MP and 94 {\\pm} 64 mm-2 BSA-MP respectively were detected to be cell-bound in the stationary setup, incubation at increasing flow velocities increasingly antagonized the attachment...

  2. Liguid and Solid Carriers Group- Strategic Directions for Hydrogen Delivery Workshop

    Broader source: Energy.gov [DOE]

    Targets, barriers and research and development priorities for solid and liquid hydrogen storage and delivery materials.

  3. Multi-functional Bio-synthetic Hybrid Nanostructures for Enhanced Cellular Uptake, Endosomal Escape and Targeted Delivery Toward Diagnostics and Therapeutics 

    E-Print Network [OSTI]

    Shrestha, Ritu 1984-

    2012-09-26T23:59:59.000Z

    incorporation of histamines to facilitate their endosomal escape for efficient delivery into the cytosol. The cSCKs were further templated onto high aspect ratio anionic cylinders to form hierarchically-assembled nanostructures that bring together individual...

  4. Self-assembled pentablock copolymers for selective and sustained gene delivery

    SciTech Connect (OSTI)

    Zhang, Bingqi

    2011-05-15T23:59:59.000Z

    The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

  5. Measured Laboratory and In-Use Fuel Economy Observed over Targeted Drive Cycles for Comparable Hybrid and Conventional Package Delivery Vehicles

    SciTech Connect (OSTI)

    Lammert, M. P.; Walkowicz, K.; Duran, A.; Sindler, P.

    2012-10-01T23:59:59.000Z

    In-use and laboratory-derived fuel economies were analyzed for a medium-duty hybrid electric drivetrain with 'engine off at idle' capability and a conventional drivetrain in a typical commercial package delivery application. Vehicles studied included eleven 2010 Freightliner P100H hybrids in service at a United Parcel Service facility in Minneapolis during the first half of 2010. The hybrids were evaluated for 18 months against eleven 2010 Freightliner P100D diesels at the same facility. Both vehicle groups use the same 2009 Cummins ISB 200-HP engine. In-use fuel economy was evaluated using UPS's fueling and mileage records, periodic ECM image downloads, and J1939 CAN bus recordings during the periods of duty cycle study. Analysis of the in-use fuel economy showed 13%-29% hybrid advantage depending on measurement method, and a delivery route assignment analysis showed 13%-26% hybrid advantage on the less kinetically intense original diesel route assignments and 20%-33% hybrid advantage on the more kinetically intense original hybrid route assignments. Three standardized laboratory drive cycles were selected that encompassed the range of real-world in-use data. The hybrid vehicle demonstrated improvements in ton-mi./gal fuel economy of 39%, 45%, and 21% on the NYC Comp, HTUF Class 4, and CARB HHDDT test cycles, respectively.

  6. Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug

    E-Print Network [OSTI]

    Hill, Wendell T.

    Nanotechnology Medical Applications Breakthroughs in nanotechnology promise to revolutionize drug manufacturing, drug delivery, and medical diagnostics. By learning how substances behave differently's Nanotechnology Center are creating novel tools and developing new methods for crucial research areas of drug

  7. Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug- Poly(Ocarboxyanhydride) Nanoconjugates Qian Yin, Rong Tong,, Yunxiang Xu, Kwanghyun Baek of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin

  8. Development and Testing of Simulation (Game) to Illustrate Basic Principles of Integrated Project Delivery and Target Value Design: A First Run Study

    E-Print Network [OSTI]

    Munankami, Manish 1972-

    2012-12-07T23:59:59.000Z

    ..................................................................... 57 x Page Figure 38 BIM presentations at big room meeting, COOK?S Children Hospital ... 69 Figure 39 Example of schedule ............................................................................... 69 Figure 40 Target Cost and achieved... (Macomber, 2009). TVD was researched and created by the Lean Project Consulting, Inc. Company formed by Greg Howell and Glenn Ballard and later joined by others. The term was first used for the Sutter Health Project (Macomber, 2009). Like TVD...

  9. Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer, Colorectal Cancer and Leukemia

    E-Print Network [OSTI]

    Zhou, Yaoqi

    Drug-drug similarity networks for anti-cancer drug discovery ­ Case studies on Breast Cancer the decades, the medical industry has been challenged with the issue of producing drugs that would avoid sidetracking to other targets (off-targets) and keep away from harmful side effects (drug adverse reactions

  10. Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport

    E-Print Network [OSTI]

    Tang, Hua, 1972-

    2002-01-01T23:59:59.000Z

    Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

  11. Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release

    E-Print Network [OSTI]

    Hoare, Todd

    Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on?off drug release upon application (and removal) ...

  12. Lorentz-force actuated needle-free injection for intratympanic pharmaceutical delivery

    E-Print Network [OSTI]

    Cloutier, Alison (Alison Marie)

    2013-01-01T23:59:59.000Z

    Delivery of pharmaceuticals to the inner ear via injection through the tympanic membrane is a method of local drug delivery that provides a non-invasive, outpatient procedure to treat many of the disorders and diseases ...

  13. Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth

    E-Print Network [OSTI]

    Wong, Cliff R. (Cliff Richard)

    2011-01-01T23:59:59.000Z

    Assembly of functional nanocomponents offers promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery ...

  14. Targeting nanodisks via a single chain variable antibody - Apolipoprotein chimera

    SciTech Connect (OSTI)

    Iovannisci, David M.; Beckstead, Jennifer A. [Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609 (United States); Ryan, Robert O. [Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609 (United States)], E-mail: rryan@chori.org

    2009-02-06T23:59:59.000Z

    Nanodisks (ND) are nanometer scale complexes of phospholipid and apolipoprotein that have been shown to function as drug delivery vehicles. ND harboring significant quantities of the antifungal agent, amphotericin B, or the bioactive isoprenoid, all trans retinoic acid, have been generated and characterized. As currently formulated, ND possess limited targeting capability. In this study, we constructed a single chain variable antibody (scFv).apolipoprotein chimera and assessed the ability of this fusion protein to form ND and recognize the antigen to which the scFv is directed. Data obtained revealed that {alpha}-vimentin scFv.apolipoprotein A-I is functional in ND formation and antigen recognition, opening the door to the use of such chimeras in targeting drug-enriched ND to specific tissues.

  15. Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs

    E-Print Network [OSTI]

    Wu, Peter I-Kung

    2007-01-01T23:59:59.000Z

    Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

  16. Drug delivery device for bladder disorders

    E-Print Network [OSTI]

    Lee, Heejin, 1976-

    2009-01-01T23:59:59.000Z

    Several pathologies associated with the bladder have wide impacts on society. Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are chronic urological conditions characterized by pain, ...

  17. Silicon Nanowires for Bioadhesion and Drug Delivery

    E-Print Network [OSTI]

    Fischer, Kathleen Elizabeth

    2010-01-01T23:59:59.000Z

    mL di water in a 15 mL centrifuge tube. Suspend in sonicatorput into another tube. Centrifuge this tube for 7 minutes at12 mL PBS ! 36 Orange Centrifuge Tubes ! 36 Green Centrifuge

  18. Gaseous Hydrogen Delivery Breakout - Strategic Directions for...

    Broader source: Energy.gov (indexed) [DOE]

    Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop...

  19. biocompatibility, stability, , p-p multi-drug

    E-Print Network [OSTI]

    Hong, Deog Ki

    , biocompatibility, stability, , p-p .2 Ř multi-drug resistance gene co- delivered photothermal , , . Ř , biocompatibility, stability, , p-p .2 Ř multi-drug resistance gene co graphene oxide-para amino benzoic acid nanosheet as effective drug delivery system to treat drug resistant

  20. Current Drug Targets, 2006, 7, 000-000 1 1389-4501/06 $50.00+.00 2006 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    and bring about a prolonged effect. By its binding to plasmatic proteins, resveratrol also exhibits a prolonged effect. Interestingly, low doses of res- veratrol can sensitize to low doses of cytotoxic drugs or chemotherapeutic strategies and is believed to be a novel weapon for new therapeutic strategies. Key Words

  1. Gaseous Hydrogen Delivery Breakout

    E-Print Network [OSTI]

    Gaseous Hydrogen Delivery Breakout Strategic Directions for Hydrogen Delivery Workshop May 7 detection Pipeline Safety: odorants, flame visibility Compression: cost, reliability #12;Breakout Session goal of a realistic, multi-energy distribution network model Pipeline Technology Improved field

  2. Delivery Tech Team

    Broader source: Energy.gov (indexed) [DOE]

    (integrated with production distr. production project) * Liquefaction - GEECO: Advanced turbo compressionexpansion - NCRC: Magnetic liquefaction Delivery Projects (Cont'd) *...

  3. adeno-associated virus-mediated delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for Different Contexts Tayeb Lemlouma1 and Nabil Layada2 OPERA Project present a framework which allows adapted content delivery for different target contexts. This...

  4. Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other...

    Broader source: Energy.gov (indexed) [DOE]

    Assumes 2005 delivery technologies * We can insert our Research Targets to see the impact Hydrogen Plants can be Located Relatively Near the Market demand Nearly all areas East of...

  5. Evaluation of Retrofit Delivery Packages

    SciTech Connect (OSTI)

    Berman, M.; Smith, P.; Porse, E.

    2013-07-01T23:59:59.000Z

    Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

  6. Tissue-specific gene delivery via nanoparticle coating Todd J. Harris a,1

    E-Print Network [OSTI]

    Bhatia, Sangeeta

    Tissue-specific gene delivery via nanoparticle coating Todd J. Harris a,1 , Jordan J. Green b,1 delivery to the spleen and bone marrow. Thus, vari- ations in nanoparticle peptide coating density can Accepted 5 October 2009 Available online 21 October 2009 Keywords: Nanoparticle Targeting Gene delivery

  7. Helical tomotherapy with dynamic running-start-stop delivery compared to conventional tomotherapy delivery

    SciTech Connect (OSTI)

    Rong, Yi, E-mail: yi.rong@osumc.edu [Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210 (United States)] [Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210 (United States); Chen, Yu; Lu, Weiguo [21st Century Oncology, Madison, Wisconsin 53719 (United States)] [21st Century Oncology, Madison, Wisconsin 53719 (United States); Shang, Lu [Guangxi Polytechnic of Construction and Technology, Nanning (China)] [Guangxi Polytechnic of Construction and Technology, Nanning (China); Zuo, Li [Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, Ohio 43210 (United States)] [Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, Ohio 43210 (United States); Chen, Quan [Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22904 (United States)] [Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia 22904 (United States)

    2014-05-15T23:59:59.000Z

    Purpose: Despite superior target dose uniformity, helical tomotherapy{sup ®} (HT) may involve a trade-off between longitudinal dose conformity and beam-on time (BOT), due to the limitation of only three available jaw sizes with the conventional HT (1.0, 2.5, and 5.0 cm). The recently introduced dynamic running-start-stop (RSS) delivery allows smaller jaw opening at the superior and inferior ends of the target when a sharp penumbra is needed. This study compared the dosimetric performance of RSS delivery with the fixed jaw HT delivery. Methods: Twenty patient cases were selected and deidentified prior to treatment planning, including 16 common clinical cases (brain, head and neck (HN), lung, and prostate) and four special cases of whole brain with hippocampus avoidance (WBHA) that require a high degree of dose modulation. HT plans were generated for common clinical cases using the fixed 2.5 cm jaw width (HT2.5) and WBHA cases using 1.0 cm (HT1.0). The jaw widths for RSS were preset with a larger size (RSS5.0 vs HT2.5 and RSS2.5 vs HT1.0). Both delivery techniques were planned based on identical contours, prescriptions, and planning objectives. Dose indices for targets and critical organs were compared using dose-volume histograms, BOT, and monitor units. Results: The average BOT was reduced from 4.8 min with HT2.5 to 2.5 min with RSS5.0. Target dose homogeneity with RSS5.0 was shown comparable to HT2.5 for common clinical sites. Superior normal tissue sparing was observed in RSS5.0 for optic nerves and optic chiasm in brain and HN cases. RSS5.0 demonstrated improved dose sparing for cord and esophagus in lung cases, as well as penile bulb in prostate cases. The mean body dose was comparable for both techniques. For the WBHA cases, the target homogeneity was significantly degraded in RSS2.5 without distinct dose sparing for hippocampus, compared to HT1.0. Conclusions: Compared to the fixed jaw HT delivery, RSS combined with a larger jaw width provides faster treatment delivery and improved cranial-caudal target dose conformity. The target coverage achieved by RSS with a large jaw width is comparable to the fixed jaw HT delivery for common cancer sites, but may deteriorate for cases where complex geometry is present in the middle part of the target.

  8. Maswadeh M Hamzah et al. / Drug Invention Today 2010, 2(2),155-159 Drug Invention Today Vol.2.Issue 2.February 2010 155-159

    E-Print Network [OSTI]

    Maswadeh M Hamzah et al. / Drug Invention Today 2010, 2(2),155-159 Drug Invention Today Vol.2.Issue of bioadhesivepolymersforlocalandsystemicdrugdeliveryformulations (1, 2). This is because these polymers can prolong the release of drug from dosage forms of the mucosa adhesive bond strength is essential for the successful application of bioadhesive drug delivery

  9. Hydrogen Delivery Infrastructure Option Analysis

    Broader source: Energy.gov (indexed) [DOE]

    Infrastructure Hydrogen Delivery Infrastructure Option Analysis Option Analysis DOE and FreedomCAR & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop...

  10. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

    E-Print Network [OSTI]

    Sahay, Gaurav

    Despite efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain unclear. Here we examine cellular uptake of short ...

  11. Stimuli Responsive Polymers for Enhanced Drug Release Applications

    E-Print Network [OSTI]

    Tam, Michael K. C.

    This talk will focus on the development of polymeric nano-structured systems for drug and gene delivery applications. Two major classes of polymer systems will be considered; namely poly(ethylene-oxide-b-propylene-oxide- ...

  12. Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes

    E-Print Network [OSTI]

    Mather, Patrick T.

    Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes Qiongyu Guo a 2009 Keywords: POSS Biodegradable polymer Drug delivery Drug-eluting stents Highly adjustable and precisely controllable drug release from a biodegradable stent coating was achieved using a unique family

  13. Experimental and computational investigations of therapeutic drug release from biodegradable poly(lactide-co-glycolide) (plg) microspheres

    E-Print Network [OSTI]

    Berchane, Nader Samir

    2009-05-15T23:59:59.000Z

    The need to tailor release-rate profiles from polymeric microspheres remains one of the leading challenges in controlled drug delivery. Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a...

  14. Targeting of drugs and nanoparticles to tumors

    E-Print Network [OSTI]

    Ruoslahti, Erkki

    The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as ...

  15. Hydrogen Delivery - Basics | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Delivery Hydrogen Delivery - Basics Hydrogen Delivery - Basics Photo of light-duty vehicle at hydrogen refueling station. Infrastructure is required to move hydrogen from the...

  16. Target isolation system, high power laser and laser peening method and system using same

    DOE Patents [OSTI]

    Dane, C. Brent (Livermore, CA); Hackel, Lloyd A. (Livermore, CA); Harris, Fritz (Rocklin, CA)

    2007-11-06T23:59:59.000Z

    A system for applying a laser beam to work pieces, includes a laser system producing a high power output beam. Target delivery optics are arranged to deliver the output beam to a target work piece. A relay telescope having a telescope focal point is placed in the beam path between the laser system and the target delivery optics. The relay telescope relays an image between an image location near the output of the laser system and an image location near the target delivery optics. A baffle is placed at the telescope focal point between the target delivery optics and the laser system to block reflections from the target in the target delivery optics from returning to the laser system and causing damage.

  17. B. Comp Dissertation SNP Data Integration and Analysis for Drug-

    E-Print Network [OSTI]

    Wong, Limsoon

    B. Comp Dissertation SNP Data Integration and Analysis for Drug- Response Biomarker Discovery 2008/2009 #12;i B. Comp Dissertation SNP Data Integration and Analysis for Drug- Response methods to develop drugs targeted at various diseases. To maximize drug viability and profit, one

  18. Hydrogen Delivery Options and Issues

    Broader source: Energy.gov (indexed) [DOE]

    stationary power site - GH2 Pipelines and Trucks, LH2 Trucks, Carriers <1.00kg of Hydrogen by 2017 Hydrogen Delivery H2 Delivery Current Status * Technology - GH2 Tube...

  19. Hydrogen Delivery- Current Technology

    Broader source: Energy.gov [DOE]

    Hydrogen is transported from the point of production to the point of use via pipeline, over the road in cryogenic liquid trucks or gaseous tube trailers, or by rail or barge. Read on to learn more about current hydrogen delivery and storage technologies.

  20. Hydrogen Delivery Mark Paster

    E-Print Network [OSTI]

    Liquids (e.g. ethanol etc.) ­ Truck: HP Gas & Liquid Hydrogen ­ Regional Pipelines ­ Breakthrough Hydrogen;Delivery Key Challenges · Pipelines ­ Retro-fitting existing NG pipeline for hydrogen ­ Utilizing existing NG pipeline for Hythane with cost effective hydrogen separation technology ­ New hydrogen pipeline

  1. Fluid delivery control system

    DOE Patents [OSTI]

    Hoff, Brian D.; Johnson, Kris William; Algrain, Marcelo C.; Akasam, Sivaprasad

    2006-06-06T23:59:59.000Z

    A method of controlling the delivery of fluid to an engine includes receiving a fuel flow rate signal. An electric pump is arranged to deliver fluid to the engine. The speed of the electric pump is controlled based on the fuel flow rate signal.

  2. Service Entry Delivery Area

    E-Print Network [OSTI]

    New South Wales, University of

    Catheter Lab Boiler House Main Entry Short Street ChapelStreet Vehicle Exit 23. Gray Street Car ParkingService Entry Waste Handling Area Delivery Area Admissions Entrance Inquiries Desk Cafeteria Coffee in July 2000 Vehicle Entry Emergency Main Entrance TOKOGARAHRAILWAYSTATION LEGEND Areas under construction

  3. Hydrogen Delivery Liquefaction and Compression

    Broader source: Energy.gov [DOE]

    Hydrogen Delivery Liquefaction and Compression - Overview of commercial hydrogen liquefaction and compression and opportunities to improve efficiencies and reduce cost.

  4. MFRC Training Development & Delivery Program - Bloodstain & Toxicology...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MFRC Training Development & Delivery Program - Bloodstain & Toxicology DESCRIPTION: The Midwest Forensics Resource Center (MFRC) Training Development and Delivery Program increases...

  5. Aggressive Underwriting and Smart Program Delivery | Department...

    Energy Savers [EERE]

    Aggressive Underwriting and Smart Program Delivery Aggressive Underwriting and Smart Program Delivery Presents information about loan underwriting funding approaches and...

  6. Identification and characterization of receptor-specific peptides for siRNA delivery

    E-Print Network [OSTI]

    Ren, Yin

    Tumor-targeted delivery of siRNA remains a major barrier in fully realizing the therapeutic potential of RNA interference. While cell-penetrating peptides (CPP) are promising siRNA carrier candidates, they are universal ...

  7. Apatite-Polymer Composites for the Controlled Dual Delivery of BMP-2 and BMP-6 for Bone Tissue Engineering

    E-Print Network [OSTI]

    Yong, Tseh-Hwan

    The release of growth factors from tissue engineering scaffolds provides signals that influence the migration, differentiation, and proliferation of cells. The incorporation of a drug delivery platform that is capable of ...

  8. Delivery Plan 2008-2012 England's Trees, Woods and Forests

    E-Print Network [OSTI]

    Strategy into action on the ground. The Plan brings together an impressive range of actions, from a wide and forests can help them achieve their aims. The second theme is targeting: of time, energy and resources of more shade in our cities and the production of renewable woodfuel. The Delivery Plan responds

  9. A Drug Administration Decision Support System Wenqi You, Alena Simalatsar, Nicolas Widmer and Giovanni De Micheli

    E-Print Network [OSTI]

    De Micheli, Giovanni

    A Drug Administration Decision Support System Wenqi You, Alena Simalatsar, Nicolas Widmer, Switzerland. Email: nicolas.widmer@chuv.ch Abstract--Drug delivery is one of the most common clinical routines-invasive and accurate way. This paper proposes a Drug Administration Decision Support System (DADSS) to help clinicians

  10. Office of Electricity Delivery

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2:Introduction toManagementOPAM PolicyOf Environmental Management MajorElectricity Delivery

  11. VIA EMAIL DELIVERY

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group current C3EDepartment ofPrivilegesUnauthorizedVIA EMAIL DELIVERY March 28,

  12. Drug Delivery DOI: 10.1002/anie.201008053

    E-Print Network [OSTI]

    Tan, Weihong

    was selected for binding with CCRF-CEM cells (CEM), a human precursor T-cell acute lymphoblastic leukemia (T

  13. Interfacial kinetics effects on transdermal drug delivery: a computer modeling

    E-Print Network [OSTI]

    Pan, Ning

    agents, which may not function well in the gastrointestinal tract or liver due to presystemic metabolism of the diffusion coefficient and the concentration gradient; here it is J Ľ ŔDij dCi dx đ1Ţ where Dij is the binary

  14. Functionalization of nanocarriers for efficient combination drug delivery

    E-Print Network [OSTI]

    Hu, Che-Ming Jack

    2011-01-01T23:59:59.000Z

    core made of poly D,L -lactic-co-glycolic acid (PLGA), a monolayer of phospholipids, and an outer corona

  15. Applications of triazine chemistry: education, remediation, and drug delivery

    E-Print Network [OSTI]

    Hatfield, Susan Elizabeth

    2009-05-15T23:59:59.000Z

    .12, 167.48, 165.36, 165.13, 164.74, 35.00, 34.96, 34.86, 14.83, 14.65, 14.37, 14.28. Results and Discussion The first method investigated for developing the undergraduate laboratory was adopted from U.S. patent 4,166,909 using sodium hydroxide...

  16. Functionalization of nanocarriers for efficient combination drug delivery

    E-Print Network [OSTI]

    Hu, Che-Ming Jack

    2011-01-01T23:59:59.000Z

    the-art synthetic stealth materials. Biodistribution studystealth moieties can be developed to mimic our bodies’ endogenous materials

  17. Local drug delivery for treatment of brain tumor associated edema

    E-Print Network [OSTI]

    Ong, Qunya

    2014-01-01T23:59:59.000Z

    Brain tumor associated edema, a common feature of malignant brain neoplasms, is a significant cause of morbidity from brain tumor. Systemic administration of corticosteroids, the standard of care, is highly effective but ...

  18. Artificial Cells for Advanced Drug Delivery - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProductsAlternativeOperational Management »Energy Poneman |Arthur

  19. Molecule Nanoweaver Improves Drug Delivery and Treatment Efficacy - Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHighandSWPA / SPRA /Ml'. WilliamEnergyMolecularMolecular-FrameInnovation

  20. Electricity Delivery and Energy Reliability | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Electricity Delivery and Energy Reliability Electricity Delivery and Energy Reliability information about the delivery of electricity and energy reliability Electricity Delivery...

  1. Targeting atherosclerosis : nanoparticle delivery for diagnosis and treatment

    E-Print Network [OSTI]

    Peters, David Thomas

    2009-01-01T23:59:59.000Z

    interventions for stenosis, or an abnormal narrowing of an artery due to atherosclerotic plaques, include percutaneous transluminal coronary

  2. Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating

    E-Print Network [OSTI]

    Schmidt, Daniel J.

    Electrically triggered drug delivery represents an attractive option for actively and remotely controlling the release of a therapeutic from an implantable device (e.g., a “pharmacy-on-a-chip”). Here we report the fabrication ...

  3. Drug discovery, design and development is an overarching theme for much of the research taking place through the University's Department of Pharmacy and Pharmacology.

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Drug discovery, design and development is an overarching theme for much of the research taking and central nervous system disorders such as epilepsy, depression, anxiety and drug abuse. The following. University of Bath Drug discovery and development at Bath #12;Tumour-selective delivery of potent drugs

  4. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

    E-Print Network [OSTI]

    Zhang, Liangfang

    -assembly of an amphiphilic triblock copolymer composed of end-to-end linkage of poly(lactic-co-glycolic-acid) (PLGA nanoparticles (NPs) for tar- geted delivery and controlled drug release may improve the therapeutic index

  5. Hydrogen Storage Technologies Hydrogen Delivery

    E-Print Network [OSTI]

    Hydrogen Storage Technologies Roadmap Hydrogen Delivery Technical Team Roadmap June 2013 #12;This). The Hydrogen Delivery Technical Team is one of 12 U.S. DRIVE technical teams ("tech teams") whose mission and clean advanced lightduty vehicles, as well as related energy infrastructure. For more information about

  6. Delivery of neuroactive peptide drugs to the brain via intranasal delivery

    E-Print Network [OSTI]

    Cros, C. D.; Toth, I.; Blanchfield, J.

    2006-10-27T23:59:59.000Z

    was sampled, placed on ice, and 75?L acetonitrile added to precipitate the plasma proteins. Samples were analysed by HPLC. Leu-Enkephalin analogues The peptides were synthesised by solid phase peptide synthesis with MBHA rink amide resin following Fmoc...

  7. Hydrogen Production and Delivery Research

    SciTech Connect (OSTI)

    Iouri Balachov, PhD

    2007-10-15T23:59:59.000Z

    In response to DOE's Solicitation for Grant Applications DE-PS36-03GO93007, 'Hydrogen Production and Delivery Research', SRI International (SRI) proposed to conduct work under Technical Topic Area 5, Advanced Electrolysis Systems; Sub-Topic 5B, High-Temperature Steam Electrolysis. We proposed to develop a prototype of a modular industrial system for low-cost generation of H{sub 2} (<$2/kg) by steam electrolysis with anodic depolarization by CO. Water will be decomposed electrochemically into H{sub 2} and O{sub 2} on the cathode side of a high-temperature electrolyzer. Oxygen ions will migrate through an oxygen-ion-conductive solid oxide electrolyte. Gas mixtures on the cathode side (H{sub 2} + H{sub 2}O) and on the anode side (CO + CO{sub 2}) will be reliably separated by the solid electrolyte. Depolarization of the anodic process will decrease the electrolysis voltage, and thus the electricity required for H{sub 2} generation and the cost of produced H{sub 2}. The process is expected to be at least 10 times more energy-efficient than low-temperature electrolysis and will generate H{sub 2} at a cost of approximately $1-$1.5/kg. The operating economics of the system can be made even more attractive by deploying it at locations where waste heat is available; using waste heat would reduce the electricity required for heating the system. Two critical targets must be achieved: an H{sub 2} production cost below $2/kg, and scalable design of the pilot H{sub 2} generation system. The project deliverables would be (1) a pilot electrolysis system for H{sub 2} generation, (2) an economic analysis, (3) a market analysis, and (4) recommendations and technical documentation for field deployment. DOE was able to provide only 200K out of 1.8M (or about 10% of awarded budget), so project was stopped abruptly.

  8. Secondary fuel delivery system

    DOE Patents [OSTI]

    Parker, David M. (Oviedo, FL); Cai, Weidong (Oviedo, FL); Garan, Daniel W. (Orlando, FL); Harris, Arthur J. (Orlando, FL)

    2010-02-23T23:59:59.000Z

    A secondary fuel delivery system for delivering a secondary stream of fuel and/or diluent to a secondary combustion zone located in the transition piece of a combustion engine, downstream of the engine primary combustion region is disclosed. The system includes a manifold formed integral to, and surrounding a portion of, the transition piece, a manifold inlet port, and a collection of injection nozzles. A flowsleeve augments fuel/diluent flow velocity and improves the system cooling effectiveness. Passive cooling elements, including effusion cooling holes located within the transition boundary and thermal-stress-dissipating gaps that resist thermal stress accumulation, provide supplemental heat dissipation in key areas. The system delivers a secondary fuel/diluent mixture to a secondary combustion zone located along the length of the transition piece, while reducing the impact of elevated vibration levels found within the transition piece and avoiding the heat dissipation difficulties often associated with traditional vibration reduction methods.

  9. National Electric Delivery Technologies Roadmap: Transforming...

    Office of Environmental Management (EM)

    Delivery Technologies Roadmap: Transforming the Grid to Revolutionize Electric Power in North America National Electric Delivery Technologies Roadmap: Transforming the Grid to...

  10. H2A Delivery Models and Results

    Broader source: Energy.gov (indexed) [DOE]

    Single delivery mode - 100 kgd or 1500 kgd forecourts * Delivery mode defined by user - Pipeline with geologic storage - Liquid hydrogen (LH2) via terminal and truck - Compressed...

  11. Hydrogen Production & Delivery | Department of Energy

    Energy Savers [EERE]

    Hydrogen Production & Delivery Hydrogen Production & Delivery "2011 DOE Hydrogen and Fuel Cells Program, and Vehicle Technologies Program Annual Merit Review and Peer Evaluation H2...

  12. Final Report - Hydrogen Delivery Infrastructure Options Analysis...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    - Hydrogen Delivery Infrastructure Options Analysis Final Report - Hydrogen Delivery Infrastructure Options Analysis This report, by the Nexant team, documents an in-depth analysis...

  13. DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy

    E-Print Network [OSTI]

    Xiao, Zeyu

    Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene ...

  14. ?[subscript v]?[subscript 3] Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug

    E-Print Network [OSTI]

    Graf, Nora

    Targeted delivery of therapeutics to tumor neovasculature is potentially a powerful approach for selective cancer treatment. Integrins are heterodimeric transmembrane proteins involved in cell adhesion and cell signaling, ...

  15. Best antibiotics for buccal delivery

    E-Print Network [OSTI]

    Goldberg, Manijeh Nazari

    2011-01-01T23:59:59.000Z

    The purpose of the research was to identify the clinical and commercial benefits of switching from intravenous (IV) to buccal delivery of antibiotics. then, the research continued to select 3-5 antibiotics that best met ...

  16. Variable delivery, fixed displacement pump

    DOE Patents [OSTI]

    Sommars, Mark F. (Sparland, IL)

    2001-01-01T23:59:59.000Z

    A variable delivery, fixed displacement pump comprises a plurality of pistons reciprocated within corresponding cylinders in a cylinder block. The pistons are reciprocated by rotation of a fixed angle swash plate connected to the pistons. The pistons and cylinders cooperate to define a plurality of fluid compression chambers each have a delivery outlet. A vent port is provided from each fluid compression chamber to vent fluid therefrom during at least a portion of the reciprocal stroke of the piston. Each piston and cylinder combination cooperates to close the associated vent port during another portion of the reciprocal stroke so that fluid is then pumped through the associated delivery outlet. The delivery rate of the pump is varied by adjusting the axial position of the swash plate relative to the cylinder block, which varies the duration of the piston stroke during which the vent port is closed.

  17. Hydrogen Delivery Infrastructure Options Analysis

    Fuel Cell Technologies Publication and Product Library (EERE)

    This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

  18. Hydrogen Distribution and Delivery Infrastructure

    Fuel Cell Technologies Publication and Product Library (EERE)

    This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

  19. Nonviral Vectors for Gene Delivery

    E-Print Network [OSTI]

    Baoum, Abdulgader Ahmed

    2011-04-26T23:59:59.000Z

    optimized for gene delivery by varying particle surface chemistry using different coating materials that adsorb to the particle surface during formation. A variety of cationic coating materials were studied and compared to more conventional surfactants used...

  20. Hydrogen Delivery Technology Roadmap, November 2005

    Fuel Cell Technologies Publication and Product Library (EERE)

    Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

  1. Radiation delivery system and method

    DOE Patents [OSTI]

    Sorensen, Scott A. (Overland Park, KS); Robison, Thomas W. (Los Alamos, NM); Taylor, Craig M. V. (Jemez Springs, NM)

    2002-01-01T23:59:59.000Z

    A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

  2. Benchmark Problem: A PK/PD Model and Safety Constraints for Anesthesia Delivery

    E-Print Network [OSTI]

    Mitchell, Ian

    Benchmark Problem: A PK/PD Model and Safety Constraints for Anesthesia Delivery Victor Gan, Guy A of the goals of general anesthesia. In this brief paper we provide a differential equation model of how Introduction General anesthesia is a broad term encompassing the use of drugs to induce and maintain three

  3. Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules

    E-Print Network [OSTI]

    Zubarev, Eugene

    online 18 May 2012 Keywords: Gold Nanoparticles Nucleic acids Drug delivery Covalent attachment Ligand functionalization, this review will focus on nanoparticle conjugates for gene therapy, antibacterial, and anticancerTherapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules

  4. Ultra-Fast Absorption of Amorphous Pure Drug Aerosols Via Deep Lung Inhalation

    E-Print Network [OSTI]

    Rabinowitz, Joshua D.

    Ultra-Fast Absorption of Amorphous Pure Drug Aerosols Via Deep Lung Inhalation JOSHUA D. RABINOWITZ inhalation. The speed of pulmonary drug absorption depends on the site of aerosol deposition within the lung incorporating this thermal aerosol technology, and its application to the delivery of alprazolam, an anti

  5. Polymer Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug

    E-Print Network [OSTI]

    Zhang, Liangfang

    Polymer Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery Santosh Aryal, Che be further es- terified with carboxyl or acid anhydride groups to provide different functionality. Ang et al the synthesis of novel acid-responsive therapeutic nanoparticles (NPs) with sub-100 nm size consisting

  6. Target assembly

    DOE Patents [OSTI]

    Lewis, Richard A. (Falls Church, VA)

    1980-01-01T23:59:59.000Z

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  7. Drug Overdose Deaths, Hospitalizations,

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug Overdose Deaths, Hospitalizations, and Emergency Department Visits in Kentucky, 2000 - 2012 #12; Kentucky Injury Preven on and Research Center Drug Overdose Deaths, Hospitaliza ons . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Drug overdose deaths, 20002012

  8. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  9. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01T23:59:59.000Z

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  10. Interactive, Internet Delivery of Visualization via Structured, Prerendered multiresolution Imagery

    E-Print Network [OSTI]

    Bethel, E. Wes; Yoon, Ilmi; Chen, Jerry

    2008-01-01T23:59:59.000Z

    I. Yoon and E. W. Bethel. “Interactive, Internet Delivery ofI. Yoon, E. W. Bethel. “Interactive, Internet Delivery ofFY 2007 Accomplishment Interactive, Internet Delivery of

  11. Agenda for the Hydrogen Delivery and Onboard Storage Analysis...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage...

  12. H2A Delivery: Forecourt Compression & Storage Optimization (Part...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    H2A Delivery: H2A Delivery: Forecourt Compression & Forecourt Compression & Storage Optimization (Part II) Storage Optimization (Part II) Hydrogen Delivery Analysis Meeting May...

  13. Accelerator target

    DOE Patents [OSTI]

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29T23:59:59.000Z

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  14. Accelerator target

    DOE Patents [OSTI]

    Schlyer, David J. (Bellport, NY); Ferrieri, Richard A. (Patchogue, NY); Koehler, Conrad (Miller Place, NY)

    1999-01-01T23:59:59.000Z

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  15. H2A Delivery: H2A Delivery

    E-Print Network [OSTI]

    forecourt Number of dispensers Capacity of hydrogen storage Size of hydrogen compressor or pump Optimize (Part II) Storage Optimization (Part II) Hydrogen Delivery Analysis Meeting May 8-9, 2007 Columbia. 408-517-1550 Reference: D0348 © 2007 TIAX LLC #12;Objectives Define the attributes of a hydrogen

  16. AUTONOMIC MULTIMEDIA DELIVERY SERVICES SELF-CONFIGURATION

    E-Print Network [OSTI]

    AUTONOMIC MULTIMEDIA DELIVERY SERVICES SELF-CONFIGURATION I. Al-oqily1 , A. Alshtnawi2 , K.M. Al-configuration architecture for multimedia delivery services. Index Terms-- self-configuration, autonomic computing, overlay

  17. Strategic Directions for Hydrogen Delivery Workshop Proceedings

    Broader source: Energy.gov [DOE]

    Proceedings from the Strategic Directions for Hydrogen Delivery Workshop held May 7-8, 2003 in Washington, DC. Author: Energetics

  18. Project #09R: Ying Luo and Niren Murthy: Multifunctional ProflavineHyaluronic Acid Conjugate (PHC): A new siRNA delivery vehicle for treating lung cancer

    E-Print Network [OSTI]

    Weber, Rodney

    ): A new siRNA delivery vehicle for treating lung cancer siRNA is emerging as the next generation of targeted therapies for lung cancer treatment. In advancing siRNA into clinical trials, safe and effective delivery vehicle, termed ProflavineHyaluronic Acid Conjugate (PHC), which can deliver siRNA to lung cancer

  19. Target-guided synthesis approach to the discovery of novel bivalent inhibitors of Glutathione Transferases 

    E-Print Network [OSTI]

    Clipson, Alexandra Jayne

    2012-06-22T23:59:59.000Z

    Target-guided synthesis is an approach to drug discovery that uses the biological target as a template to direct synthesis of its own best inhibitors from small molecule fragments. The process bridges the gap between ...

  20. Delivery of Hydrogen Produced from Natural Gas

    E-Print Network [OSTI]

    for transportation and stationary power. DOE Milestone #12;Hydrogen Delivery Options · Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areasDelivery of Hydrogen Produced from Natural Gas Christopher Freitas Office of Natural Gas

  1. DOI: 10.1002/cmdc.200700121 Co-Delivery of Hydrophobic and

    E-Print Network [OSTI]

    Zhang, Liangfang

    ) as a model small molecule hydrophobic drug; doxorubicin (Dox) as a model intercalating hydrophilic drug- polymer as a model controlled release polymer system, we de- veloped targeted NPs that can co-deliver Dox stem region that is the preferred binding site of Dox.[16] Incubation of Dox with the A10 PSMA aptamer

  2. Engineered nanomedicine for myeloma and bone microenvironment targeting

    E-Print Network [OSTI]

    Swami, Archana

    Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability ...

  3. ORIGINAL PAPER Specificity and success of oral-bait delivery to Eurasian wild

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ORIGINAL PAPER Specificity and success of oral-bait delivery to Eurasian wild boar in Mediterranean December 2010 /Published online: 21 December 2010 # Springer-Verlag 2010 Abstract Eurasian wild boar (Sus of this study was to determine the proportion of young and adult wild boar and non-target animals that consumed

  4. Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive

    E-Print Network [OSTI]

    Gao, Jinming

    the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to rv 3, provide a unique core-shell architecture wherein the hy- drophobic core serves as a natural carrier.3-5 Sterically stabilized micelles by the PEG corona have shown prolonged blood circulation

  5. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01T23:59:59.000Z

    and the risk of illicit drug use: the Adverse Childhoodalcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.

  6. Annu. Rev. Med. 2002. 53:595614 RATIONAL APPROACH TO AIDS DRUG DESIGN

    E-Print Network [OSTI]

    Annu. Rev. Med. 2002. 53:595­614 RATIONAL APPROACH TO AIDS DRUG DESIGN THROUGH STRUCTURAL BIOLOGY than a dozen drugs in the past 15 years for the treatment of AIDS offer an excellent example of progress in the field of rational drug design. At this time, the principal targets are reverse

  7. MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design

    E-Print Network [OSTI]

    Powers, Robert

    MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling to bind a target protein while obtaining structure-related information as part of a struc- ture-based drug for drug discovery is the utilization of a biological assay to screen a large library of compounds (>100

  8. Formation of drug-bearing vesicles in mixed colloids of bile salts and phosphatidylcholine

    SciTech Connect (OSTI)

    Hjelm, R.P.; Mang, J. [Los Alamos National Lab., NM (United States); Hofmann, A.F.; Schteingart, C. [Univ. of California, San Diego, CA (United States); Alkan-Onyuksel, H.; Ayd, S. [Univ. of Illinois, Urbana, IL (United States)

    1997-11-01T23:59:59.000Z

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The authors used small-angle neutron scattering to study drug interactions with mixed colloids of bile salt and phosphatidylcholine. Because the mixed colloids form liposomes spontaneously, this system is a model for drug-bile interactions that are important in understanding the efficacy of oral drug formulations and in advanced applications for liposome drug delivery systems. The authors studied particle formation in incorporation of enzymatic products formed in the gut and the effects of cholesteric drugs and taxol on vesicle formation. The studies show that particle morphology is not affected by inclusion of most cholesteric drugs and taxol, and is not affected by incorporation of the products of enzymatic action. The findings suggest that particle form is important for the physiological function of bile and they are beginning to show which drugs affect liposome formation.

  9. DOI: 10.1002/cmdc.200800122 HER-2-Targeted NanoparticleAffibody Bioconjugates for Cancer Therapy

    E-Print Network [OSTI]

    Zhang, Liangfang

    shown that this class of molecule can se- lectively bind to HER-2-overexpressing cell lines (SKBR-3 drug toxicity, and maintaining a relatively high concentration of drug at the site of interest.[1 drugs to diseased cells. The first examples of targeted NPs were reported in 1980, and despite nearly

  10. Fiber coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO)

    2008-08-12T23:59:59.000Z

    A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

  11. Electricity Delivery and Energy Reliability

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube|6721 Federal Register / Vol.6:Energy| DepartmentFederalCommitteeDelivery and

  12. Hydrogen Delivery Infrastructure Analysis, Options and Trade...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Analysis, Options and Trade-offs, Transition and Long-term Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long-term Presentation on Hydrogen...

  13. Dynamic Network Utility Maximization with Delivery Contracts

    E-Print Network [OSTI]

    Nikolaos Trichakis

    2007-09-30T23:59:59.000Z

    Sep 30, 2007 ... Dynamic Network Utility Maximization with Delivery Contracts. Nikolaos ... We briefly describe a heuristic, based on model predictive control, ...

  14. Gaseous Hydrogen Delivery Breakout - Strategic Directions for...

    Broader source: Energy.gov (indexed) [DOE]

    System Issues: need to assess delivery options in context of total system Materials: corrosion, H2 permeability Construction: welding, joining Maintenance and Operation: leak...

  15. Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Energy Savers [EERE]

    Roadmap to Achieve Energy Delivery Systems Cybersecurity 7 Our finances, transportation, health care, water supply, and emergency services depend on reliable energy. Building and...

  16. Delivery Tech Team Oak Ridge National Laboratory

    E-Print Network [OSTI]

    Technology Components Sensors & Controls Health & Human Safety Codes & Standards Right of Ways/Regeneration Delivery Technology Components Pipelines(transmission & distribution) Trucks, Rail, Barges Compressors

  17. Predicting selective drug targets in cancer through metabolic networks

    E-Print Network [OSTI]

    Ruppin, Eytan

    facilitating the uptake and conversion of nutrients into biomass (Vander Heiden et al, 2009). Numerous studies adapt their metabolism to facilitate biomass formation to enable proli- feration suggests that it may- growing microorganisms (Price et al, 2004).

  18. Gastric H,K-ATPase as a drug target

    E-Print Network [OSTI]

    Shin, Jai M; Sachs, G

    2006-01-01T23:59:59.000Z

    Review article: Helicobacter pylori and gastro- oesophagealWL: The treatment of Helicobacter pylori infection in thewith infection by Helicobacter pylori and the realization

  19. Gastric H,K-ATPase as a drug target

    E-Print Network [OSTI]

    Shin, Jai M; Sachs, G

    2006-01-01T23:59:59.000Z

    cations. J Biol Chem Fukushima Y, Nakao M: Changes inChem 1980;255(16):7813-9. Fukushima Y, Post RL: Binding of

  20. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool of tomorrowChemCamInnovationDepartmentTopo

  1. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Tool of

  2. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesisAppliances » Top Innovative Scienceastrophysics

  3. Fiber laser coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

    2008-03-04T23:59:59.000Z

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  4. Chemoinformatics in drug development

    E-Print Network [OSTI]

    2012-05-01T23:59:59.000Z

    ORAL PRESENTATION Open Access Chemoinformatics in drug development Colin R Groom From 7th German Conference on Chemoinformatics: 25 CIC-Workshop Goslar, Germany. 6-8 November 2011 It would be unimaginable to prosecute a drug discovery program... to the contributions that can be made as a candidate molecule progresses towards becoming part of a drug substance. This presentation will highlight the opportunities for the application of chemoinformatics techniques to the area of pharmaceutical materials science, a...

  5. First SNS Target Replacement

    E-Print Network [OSTI]

    McDonald, Kirk

    First SNS Target Replacement Experience M. Dayton, M. Rennich, Van Graves, J. DeVore Presented by T.S. Department of Energy AHIP Workshop Oct. 2009 Overview · Initial Target Replacement · Target Maintenance-Battelle for the U.S. Department of Energy AHIP Workshop Oct. 2009 First SNS Target Replacement · Replacement

  6. MECO Production Target Developments

    E-Print Network [OSTI]

    McDonald, Kirk

    be reoptimized Tungsten target Simulations of design parameters with GEANT3 indicate that both production targetMECO Production Target Developments James L. Popp University of California, Irvine NuFact'03 Columbia, June, 2003 #12;June, 2003J.L.Popp, UCI MECO Production Target 2 MECO Collaboration Institute

  7. Impact of cost constraints on aesthetic ranking following Target Value Design exercises

    E-Print Network [OSTI]

    Rybkowski, Zofia K.; Munankami, Manish; Gottipati, Udaya; Lavy, Sarel; Fernández-Solis, Jose

    2011-07-13T23:59:59.000Z

    IMPACT OF COST CONSTRAINTS ON AESTHETIC RANKING FOLLOWING TARGET VALUE DESIGN EXERCISES Zofia K. Rybkowski1, Manish Munankami2, Udaya Gottipati3, Jose Fernández-Solís 4, and Sarel Lavy5 PURPOSE: Target Value Design (TVD) is a project... delivery subset that shares methodologies with Target Costing and Value Engineering, but is performed within the context of lean construction. TVD has been shown to generate first cost savings of approximately 20% on case study projects. A concern voiced...

  8. Office of Electricity Delivery and Energy Reliability Recovery...

    Energy Savers [EERE]

    Electricity Delivery and Energy Reliability Recovery Program Plan Office of Electricity Delivery and Energy Reliability Recovery Program Plan Microsoft Word - OE PSRP June 5 2009...

  9. Sandia National Laboratories: DOE Office of Electricity Delivery...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    & CapabilitiesCapabilitiesDOE Office of Electricity Delivery & Energy Reliability (OE) Energy Storage Safety Workshop DOE Office of Electricity Delivery & Energy Reliability...

  10. Energy-Efficient Melting and Direct Delivery of High Quality...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum itmdelivery.pdf More...

  11. 2012 Annual Planning Summary for Electricity Delivery and Energy...

    Energy Savers [EERE]

    2012 Annual Planning Summary for Electricity Delivery and Energy Reliability 2012 Annual Planning Summary for Electricity Delivery and Energy Reliability The ongoing and projected...

  12. April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure...

    Energy Savers [EERE]

    April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure Initiative FOA April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure Initiative FOA March 23,...

  13. Office of Electricity Delivery And Energy Reliability To Hold...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy...

  14. Career Opportunities with the Office of Electricity Delivery...

    Energy Savers [EERE]

    Career Opportunities with the Office of Electricity Delivery & Energy Reliability (OE) Career Opportunities with the Office of Electricity Delivery & Energy Reliability (OE) Career...

  15. Status and EAC Recommendations for Electricity Delivery Workforce...

    Energy Savers [EERE]

    Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) This memo,...

  16. Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Permeability and Integrity of Hydrogen Delivery Pipelines Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines Project Objectives: To gain basic understanding of...

  17. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...

    Energy Savers [EERE]

    H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and...

  18. Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Vehicles Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery Vehicles The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a...

  19. accurate sobp delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 19 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  20. antiretroviral treatment delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

  1. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...

    Broader source: Energy.gov (indexed) [DOE]

    Meeting on Hydrogen Delivery Modeling and Analysis FreedomCAR and Fuels Partnership Hydrogen Delivery, Storage and Fuel Pathway Integration Tech Teams May 8-9, 2007 Energetics...

  2. aerosol delivery aad: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 24 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  3. avtip delivery order: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 25 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  4. adaptive aerosol delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 45 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  5. aerial dispersant delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 72 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  6. adenoviral gene delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

  7. adenoviral transgene delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 64 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  8. arthritis boron delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 58 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  9. Record of Categorical Exclusion (CX) Office of Electricity Delivery...

    Office of Environmental Management (EM)

    Office of Electricity Delivery and Energy Reliability (OE): EA-405 Del Norte Energy LLC Record of Categorical Exclusion (CX) Office of Electricity Delivery and Energy Reliability...

  10. Secretary Steven Chu's Remarks as Prepared for Delivery at the...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Chu's Remarks as Prepared for Delivery at the Polytechnic Institute of New York University Secretary Steven Chu's Remarks as Prepared for Delivery at the Polytechnic Institute...

  11. 2013 Annual Planning Summary for the Office of Electricity Delivery...

    Energy Savers [EERE]

    Electricity Delivery and Energy Reliability 2011 Annual Planning Summary for Electricity Delivery and Energy Reliability (OE) U.S.-Canada Clean Energy Dialogue (CED) Action Plan...

  12. Renewable Electricity Generation and Delivery at the Sacramento...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Electricity Generation and Delivery at the Sacramento Municipal Utility District Renewable Electricity Generation and Delivery at the Sacramento Municipal Utility District Dairy...

  13. Special Delivery for Sustainability: Clean Cities Supports UPS...

    Office of Environmental Management (EM)

    Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding Natural Gas Operations Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding...

  14. H2A Delivery: Forecourt Compression & Storage Optimization (Part...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    H2A Delivery: Forecourt Compression & Storage Optimization (Part II) H2A Delivery: Forecourt Compression & Storage Optimization (Part II) Presentation by Matthew Hooks of TIAX at...

  15. Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM...

    Office of Environmental Management (EM)

    Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results This presentation by...

  16. Hydrogen Delivery R&D Activities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    R&D Activities Hydrogen Delivery R&D Activities Hydrogen delivery technology may encompass several options over the short and long terms. The transportation and distribution...

  17. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, R.J.

    1984-10-10T23:59:59.000Z

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  18. Electrically charged targets

    DOE Patents [OSTI]

    Goodman, Ronald K. (Livermore, CA); Hunt, Angus L. (Alamo, CA)

    1984-01-01T23:59:59.000Z

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  19. Fixed drug eruption caused by the Japanese herbal drug kakkonto

    E-Print Network [OSTI]

    Furuichi, Megumi; Hara, Hiroshi; Asano, Yukie; Makino, Teruhiko; Shimizu, Tadamichi

    2010-01-01T23:59:59.000Z

    Topical provocation of fixed drug eruption. Br J Dermatol.neglected offender for fixed drug eruptions. Eur J Dermatoloral and non-oral herbal drugs may cause FDE. References 1.

  20. Drug Use and Drug Policy in a Prohibition Regime

    E-Print Network [OSTI]

    MacCoun, Robert; Martin, Karin D.

    2008-01-01T23:59:59.000Z

    Prisoners (prior to offense), Drug-related Emergency RoomVisits, 2007 DAWN All illicit drugs Marijuana Cocaine Crack2/4/2008 - 41 Other Sentence Drug Sentence Federal Prisoners

  1. Magnetically attached sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1994-02-15T23:59:59.000Z

    An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

  2. Adolescent drug abuse - Awareness & prevention

    E-Print Network [OSTI]

    Chakravarthy, Bharath; Shah, Shyam; Lotfipour, Shahram

    2013-01-01T23:59:59.000Z

    alcohol, tobacco and other drug use. Int Rev Psychiatry.therapy for adolescent drug abuse. J Clin Child Psychol.outcomes in an indicated drug prevention program for high-

  3. Anticoagulation Drug Therapy: A Review

    E-Print Network [OSTI]

    Harter, Katherine; Levine, Michael; Henderson, Sean O.

    2015-01-01T23:59:59.000Z

    et al. Anticoagulation Drug Therapy: A Review 15. NishijimaRandomized antiplatelet drugs. In: Goodman & Gilman’s The2008;24:2757-65. Cardiovasc Drugs. 2006;6:265-85. 34. Nordt

  4. Research Article Theme: Nanoparticles in Vaccine Delivery

    E-Print Network [OSTI]

    Salem, Aliasger K.

    Research Article Theme: Nanoparticles in Vaccine Delivery Guest Editor: Aliasger K. Salem with the Der p2 coated on 9-m-sized empty PLGA particles showed increased levels of IgE and IgG1 antibodies

  5. Coordinated part delivery using distributed planning

    E-Print Network [OSTI]

    Bolger, Adrienne (Adrienne M.)

    2010-01-01T23:59:59.000Z

    In this thesis, we develop a distributed mobile robot platform to deliver parts around a model construction site. The platform's robots, specialized into delivery robots and assembly robots, use a distributed coverage ...

  6. Categorical Exclusion Determinations: Office of Electricity Delivery...

    Energy Savers [EERE]

    Power, Inc. Export Authorization CX(s) Applied: B4.2 Date: 09182012 Location(s): Canada Offices(s): Electricity Delivery and Energy Reliability September 18, 2012 CX-009406:...

  7. Composite gelatin delivery system for bone regeneration

    E-Print Network [OSTI]

    Hager, Elizabeth A. (Elizabeth Ann)

    2005-01-01T23:59:59.000Z

    In this thesis, the chemical/mechanical properties and biocompatibility of gelatin were investigated to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery ...

  8. Social network support for data delivery infrastructures

    E-Print Network [OSTI]

    Sastry, Nishanth Ramakrishna

    2011-10-11T23:59:59.000Z

    in social networks can be used to tailor content staging decisions to the user base and thereby build better data delivery infrastructures. This claim is supported by two case studies, which apply social information in challenging situations where...

  9. Essays on health care delivery and financing

    E-Print Network [OSTI]

    Chan, David C. (David Cchimin)

    2013-01-01T23:59:59.000Z

    This thesis contains essays on health care delivery and financing. Chapter 1 studies the effect of organizational structure on physician behavior. I investigate this by studying emergency department (ED) physicians who ...

  10. Using analytics to improve delivery performance

    E-Print Network [OSTI]

    Napolillo, Tacy J. (Tacy Jean)

    2014-01-01T23:59:59.000Z

    Delivery Precision is a key performance indicator that measures Nike's ability to deliver product to the customer in full and on time. The objective of the six-month internship was to quantify areas in the supply chain ...

  11. Delivery and Receipt | Department of Energy

    Energy Savers [EERE]

    (301) 903-3790; Phone: (301) 903-6492 Delivery Addresses for the Loading Docks U.S. Department of Energy Forrestal Building 1000 Independence Avenue, S.W. Washington, D.C. 20585...

  12. Time-Resolved SAXS/WAXS Study of the Phase Behavior and Microstructural Evolution of Drug/PEG Solid Dispersions

    SciTech Connect (OSTI)

    Zhu, Qing; Harris, Michael T.; Taylor, Lynne S. (Purdue)

    2013-03-07T23:59:59.000Z

    Simultaneous small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) was employed to elucidate the physical state and location of various small molecule drugs blended with polyethylene glycol (PEG), as well as the time dependent microstructural evolution of the systems. Samples were prepared by comelting physical mixtures of the drug and PEG, followed by solidification at 25 C. The model drugs selected encompassed a wide variety of physicochemical properties in terms of crystallization tendency and potential for interaction with PEG. It was observed that compounds which crystallized rapidly and had weak interactions with PEG tended to be excluded from the interlamellar region of the PEG matrix. In contrast, drugs which had favorable interactions with PEG were incorporated into the interlamellar regions of the polymer up until the point at which the drug crystallized whereby phase separation occurred. These factors are likely to impact the effectiveness of drug/PEG systems as drug delivery systems.

  13. TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)

    SciTech Connect (OSTI)

    Dunne, A M

    2010-11-30T23:59:59.000Z

    The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition scheme is an essential component of an acceptably low-risk solution. The degree of coupling seen on NIF between driver and target performance mandates that little deviation be adopted from the NIF geometry and beamline characteristics. Similarly, the strong coupling between subsystems in an operational power plant mandates that a self-consistent solution be established via an integrated facility delivery project. The benefits of separability of the subsystems within an IFE plant (driver, chamber, targets, etc.) emerge in the operational phase of a power plant rather than in its developmental phase. An optimized roadmap for IFE delivery needs to account for this to avoid nugatory effort and inconsistent solutions. For LIFE, a system design has been established that could lead to an operating power plant by the mid-2020s, drawing from an integrated subsystem development program to demonstrate the required technology readiness on a time scale compatible with the construction plan. Much technical development work still remains, as does alignment of key stakeholder groups to this newly emerging development option. If the required timeline is to be met, then preparation of a viable program is required alongside the demonstration of ignition on NIF. This will enable timely analysis of the technical and economic case and establishment of the appropriate delivery partnership.

  14. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01T23:59:59.000Z

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  15. Target Value Design: Applications to Newborn Intensive Care Units

    E-Print Network [OSTI]

    Rybkowski, Zofia K.; Shepley, Mardelle McCuskey; Ballard, H. Glenn

    2015-02-08T23:59:59.000Z

    inducing flow, has been optimizing the three- legged stool of construction management—time, cost, quality and safety (as the seat) (Jackson, 2004). Value is defined as what customers need to accomplish their purposes. Historically, TVD de- veloped... (Architecture); E (Engineering); CM (Construction Management) Table 1. A Comparison of Two Delivery Methods Note: OAEC stakeholders for the field house at St. Olaf engaged in target-costing exercises as a way to reduce cost and schedule—and enhance value...

  16. Drug Information Chart Notes Drug ad (intrinsic bias)

    E-Print Network [OSTI]

    Abolmaesumi, Purang

    Drug Information Chart Notes Drug ad (intrinsic bias) Trade name Different for each company Dosage Same or different? A drug in a different dosage can be used for a different therapy. Precautions Check for pregnancy A complete book on drugs in pregnancy and lactation in bibliography. (unbiased

  17. A study of IMRT planning parameters on planning efficiency, delivery efficiency, and plan quality

    SciTech Connect (OSTI)

    Mittauer, Kathryn [Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, Florida 32603 and J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 (United States); Lu Bo; Yan Guanghua; Kahler, Darren; Amdur, Robert; Liu Chihray [Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, Florida 32603 (United States); Gopal, Arun [Department of Radiation Oncology, New York-Presbyterian Hospital, Columbia University, New York, New York 10032 (United States)

    2013-06-15T23:59:59.000Z

    Purpose: To improve planning and delivery efficiency of head and neck IMRT without compromising planning quality through the evaluation of inverse planning parameters.Methods: Eleven head and neck patients with pre-existing IMRT treatment plans were selected for this retrospective study. The Pinnacle treatment planning system (TPS) was used to compute new treatment plans for each patient by varying the individual or the combined parameters of dose/fluence grid resolution, minimum MU per segment, and minimum segment area. Forty-five plans per patient were generated with the following variations: 4 dose/fluence grid resolution plans, 12 minimum segment area plans, 9 minimum MU plans, and 20 combined minimum segment area/minimum MU plans. Each plan was evaluated and compared to others based on dose volume histograms (DVHs) (i.e., plan quality), planning time, and delivery time. To evaluate delivery efficiency, a model was developed that estimated the delivery time of a treatment plan, and validated through measurements on an Elekta Synergy linear accelerator. Results: The uncertainty (i.e., variation) of the dose-volume index due to dose calculation grid variation was as high as 8.2% (5.5 Gy in absolute dose) for planning target volumes (PTVs) and 13.3% (2.1 Gy in absolute dose) for planning at risk volumes (PRVs). Comparison results of dose distributions indicated that smaller volumes were more susceptible to uncertainties. The grid resolution of a 4 mm dose grid with a 2 mm fluence grid was recommended, since it can reduce the final dose calculation time by 63% compared to the accepted standard (2 mm dose grid with a 2 mm fluence grid resolution) while maintaining a similar level of dose-volume index variation. Threshold values that maintained adequate plan quality (DVH results of the PTVs and PRVs remained satisfied for their dose objectives) were 5 cm{sup 2} for minimum segment area and 5 MU for minimum MU. As the minimum MU parameter was increased, the number of segments and delivery time were decreased. Increasing the minimum segment area parameter decreased the plan MU, but had less of an effect on the number of segments and delivery time. Our delivery time model predicted delivery time to within 1.8%. Conclusions: Increasing the dose grid while maintaining a small fluence grid allows for improved planning efficiency without compromising plan quality. Delivery efficiency can be improved by increasing the minimum MU, but not the minimum segment area. However, increasing the respective minimum MU and/or the minimum segment area to any value greater than 5 MU and 5 cm{sup 2} is not recommended because it degrades plan quality.

  18. Main chain acid-degradable polymers for the delivery of bioactive materials

    DOE Patents [OSTI]

    Frechet, Jean M. J. (Oakland, CA); Standley, Stephany M. (Evanston, IL); Jain, Rachna (Milpitas, CA); Lee, Cameron C. (Cambridge, MA)

    2012-03-20T23:59:59.000Z

    Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.

  19. The Amphiphilic Self-Assembling Peptide EAK16-I as a Potential Hydrophobic Drug Carrier

    E-Print Network [OSTI]

    Wang, Jing

    2008-01-01T23:59:59.000Z

    It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is ...

  20. Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies

    E-Print Network [OSTI]

    Wong, Albert, S.M. Massachusetts Institute of Technology

    2009-01-01T23:59:59.000Z

    'Smart' targeted drug carriers have long been sought after in the treatment of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited ...

  1. SelfSelf--healing Powerhealing Power Delivery InfrastructureDelivery Infrastructure

    E-Print Network [OSTI]

    Amin, S. Massoud

    Network/Systems Initiative Complex interactive networks: · Energy infrastructure: Electric power gridsSelfSelf--healing Powerhealing Power Delivery InfrastructureDelivery Infrastructure Massoud Amin, D developed while the author was at the Electric Power Research Institute (EPRI) in Palo Alto, CA. EPRI

  2. Non-traditional platinum compounds for improved cellular accumulation and tumor targeting

    E-Print Network [OSTI]

    Lovejoy, Katherine Summer, 1981-

    2009-01-01T23:59:59.000Z

    Chapter 1. Introduction to Non-Traditional Platinum Compounds for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration ...

  3. Crucial stages of protein folding through a solvable model: Predicting target sites

    E-Print Network [OSTI]

    Cecconi, Fabio

    Crucial stages of protein folding through a solvable model: Predicting target sites for enzyme. Keywords: Protein-folding modeling; prediction of key folding sites; HIV-1 protease; drug resistance One

  4. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

    E-Print Network [OSTI]

    Babu, M. Madan

    of drug resistance. Historically, this important endeavor has been primarily focused on case-by-case studies of antibacterial resistance, but technological developments have resulted in several genome-wide approaches to drug target discovery. Examples of these include studies of gene expression changes after

  5. Smart drug discovery leveraging innovative technologies and predictive knowledge

    E-Print Network [OSTI]

    Cai, Long

    the risk of failure. Owing to the integration of key in silico and experimental tools. A positive aspect of this paradigm shift includes faster,strategic decision making with respect to drug targets from the human genome pro- vides opportunities for detailed analysis of structure and function

  6. An Implantable Bio-Micro-system for Drug Monitoring

    E-Print Network [OSTI]

    De Micheli, Giovanni

    An Implantable Bio-Micro-system for Drug Monitoring Sara Ghoreishizadeh, Enver G. Kilinc, Camilla of the implantable monitoring system for long- term duration has many challenges. First, a multi-target biosen- sor coil; (ii) A power manage- ment IC dealing with the energy source of the implantable microsystem

  7. Target Cost Management Strategy

    E-Print Network [OSTI]

    Okano, Hiroshi

    1996-01-01T23:59:59.000Z

    Target cost management (TCM) is an innovation of Japanese management accounting system and by common sense has been considered with great interest by practitioners. Nowadays, TCM related

  8. Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth

    E-Print Network [OSTI]

    of the disease. Thus, drugs that selectively target cancer stem cells offer great promise for cancer treatment and chemotherapeutic drugs to improve treatment of patients with breast (and possibly other) cancers. [Cancer Res 2009;69(19):7507­11] Introduction Chemotherapeutic treatments for cancer can effectively reduce tumor mass, but the disease often

  9. Renewable energy delivery systems and methods

    DOE Patents [OSTI]

    Walker, Howard Andrew

    2013-12-10T23:59:59.000Z

    A system, method and/or apparatus for the delivery of energy at a site, at least a portion of the energy being delivered by at least one or more of a plurality of renewable energy technologies, the system and method including calculating the load required by the site for the period; calculating the amount of renewable energy for the period, including obtaining a capacity and a percentage of the period for the renewable energy to be delivered; comparing the total load to the renewable energy available; and, implementing one or both of additional and alternative renewable energy sources for delivery of energy to the site.

  10. Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy

    SciTech Connect (OSTI)

    Diot, Quentin; Kavanagh, Brian; Timmerman, Robert; Miften, Moyed [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States); Department of Radiation Oncology, University of Texas Southwestern Medical School, Dallas, Texas 75390 (United States); Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045 (United States)

    2012-01-15T23:59:59.000Z

    Purpose: To describe biological-based optimization and Monte Carlo (MC) dose calculation-based treatment planning for volumetric modulated arc therapy (VMAT) delivery of stereotactic body radiation therapy (SBRT) in lung, liver, and prostate patients. Methods: Optimization strategies and VMAT planning parameters using a biological-based optimization MC planning system were analyzed for 24 SBRT patients. Patients received a median dose of 45 Gy [range, 34-54 Gy] for lung tumors in 1-5 fxs and a median dose of 52 Gy [range, 48-60 Gy] for liver tumors in 3-6 fxs. Prostate patients received a fractional dose of 10 Gy in 5 fxs. Biological-cost functions were used for plan optimization, and its dosimetric quality was evaluated using the conformity index (CI), the conformation number (CN), the ratio of the volume receiving 50% of the prescription dose over the planning target volume (Rx/PTV50). The quality and efficiency of the delivery were assessed according to measured quality assurance (QA) passing rates and delivery times. For each disease site, one patient was replanned using physical cost function and compared to the corresponding biological plan. Results: Median CI, CN, and Rx/PTV50 for all 24 patients were 1.13 (1.02-1.28), 0.79 (0.70-0.88), and 5.3 (3.1-10.8), respectively. The median delivery rate for all patients was 410 MU/min with a maximum possible rate of 480 MU/min (85%). Median QA passing rate was 96.7%, and it did not significantly vary with the tumor site. Conclusions: VMAT delivery of SBRT plans optimized using biological-motivated cost-functions result in highly conformal dose distributions. Plans offer shorter treatment-time benefits and provide efficient dose delivery without compromising the plan conformity for tumors in the prostate, lung, and liver, thereby improving patient comfort and clinical throughput. The short delivery times minimize the risk of patient setup and intrafraction motion errors often associated with long SBRT treatment delivery times.

  11. Neutrino Factory Target Vessel

    E-Print Network [OSTI]

    McDonald, Kirk

    by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 Cooling Channel in both walls for draining · Downstream end can be shortened, assuming the window cooling is adequate #12;11 Managed by UT-Battelle for the U.S. Department of Energy Target Vessel Update 26 June 2012 Remote Handling

  12. Fluid delivery control system | OSTI, US Dept of Energy, Office...

    Office of Scientific and Technical Information (OSTI)

    Fluid delivery control system Re-direct Destination: A method of controlling the delivery of fluid to an engine includes receiving a fuel flow rate signal. An electric pump is...

  13. H2A Delivery Scenario Model and Analyses

    Broader source: Energy.gov (indexed) [DOE]

    H2A Delivery Scenario Model and Analyses Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2...

  14. Improvements to Hydrogen Delivery Scenario Analysis

    E-Print Network [OSTI]

    Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad and storage are at or adjacent to Liquid Hydrogen (LH) TruckH2 Production 100 or 1500 kg/d Compressed H2 (CH) Truck H2 Production 3 or 7 kpsi 100 or 1500 kg/d H2 Production Gaseous H2 Pipeline 100 or 1500 kg

  15. PREPARING THE VIRTUAL CLASSROOM FOR DISTANCE DELIVERY

    E-Print Network [OSTI]

    Dyer, Bill

    of humans and their companion domestic animals and livestock. Students learn that there are certain "at riskPREPARING THE VIRTUAL CLASSROOM FOR DISTANCE DELIVERY: MEDICAL-VETERINARY ENTOMOLOGY CLINICS laboratory," library materials, conventional lectures and the 43 virtual patients in the clinics

  16. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Broader source: Energy.gov (indexed) [DOE]

    Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry...

  17. Integer linear programming models for a cement delivery problem

    E-Print Network [OSTI]

    Hertz, Alain

    Integer linear programming models for a cement delivery problem Alain Hertz D´epartement de math.uldry@unifr.ch and marino.widmer@unifr.ch April 4, 2011 Abstract We consider a cement delivery problem with an heterogeneous in [14], [15] and [16] and are reviewed in [4]. In this paper, we study a cement delivery problem which

  18. Design of Microfabricated Inductors for Microprocessor Power Delivery

    E-Print Network [OSTI]

    Design of Microfabricated Inductors for Microprocessor Power Delivery G. J. Mehas K. D. Coonley C/99 Design of Microfabricated Inductors for Microprocessor Power Delivery Gustavo J. Mehas, Kip D. Coonley://engineering.dartmouth.edu/inductor/ Abstract-- Microfabricated inductor designs are proposed for converters for microprocessor power delivery

  19. Essays on Drug Use and Crime

    E-Print Network [OSTI]

    Deza, Monica

    2012-01-01T23:59:59.000Z

    Prinz. A. , 1997, Do European drugs policies mater? Economicruin? Sequences of initiation to drugs and crime in Britain.and P. Grimes, 2001, Adolescent Drug Use and Educational

  20. Structural Genomics and Drug Discovery for Infectious Diseases

    SciTech Connect (OSTI)

    Anderson, W.F.

    2010-09-03T23:59:59.000Z

    The application of structural genomics methods and approaches to proteins from organisms causing infectious diseases is making available the three dimensional structures of many proteins that are potential drug targets and laying the groundwork for structure aided drug discovery efforts. There are a number of structural genomics projects with a focus on pathogens that have been initiated worldwide. The Center for Structural Genomics of Infectious Diseases (CSGID) was recently established to apply state-of-the-art high throughput structural biology technologies to the characterization of proteins from the National Institute for Allergy and Infectious Diseases (NIAID) category A-C pathogens and organisms causing emerging, or re-emerging infectious diseases. The target selection process emphasizes potential biomedical benefits. Selected proteins include known drug targets and their homologs, essential enzymes, virulence factors and vaccine candidates. The Center also provides a structure determination service for the infectious disease scientific community. The ultimate goal is to generate a library of structures that are available to the scientific community and can serve as a starting point for further research and structure aided drug discovery for infectious diseases. To achieve this goal, the CSGID will determine protein crystal structures of 400 proteins and protein-ligand complexes using proven, rapid, highly integrated, and cost-effective methods for such determination, primarily by X-ray crystallography. High throughput crystallographic structure determination is greatly aided by frequent, convenient access to high-performance beamlines at third-generation synchrotron X-ray sources.

  1. Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer

    E-Print Network [OSTI]

    Toyokawa, Gouji; Masuda, Ken; Daigo, Yataro; Cho, Hyun-Soo; Yoshimatsu, Masanori; Takawa, Masashi; Hayami, Shinya; Maejima, Kazuhiro; Chino, Makoto; Field, Helen I; Neal, David E; Tsuchiya, Eiju; Ponder, Bruce A J; Maehara, Yoshihiko; Nakamura, Yusuke; Hamamoto, Ryuji

    2011-05-28T23:59:59.000Z

    Abstract Background The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This can only be achieved if the drug used is against a specific target...

  2. SNS Target Systems Operational

    E-Print Network [OSTI]

    McDonald, Kirk

    a failed gas seal on the shaft and leaking oil seals but has operated well since then · The moderator 7.5 k First target replacement · No observed corrosion · Internal Boroscope examination in progress · ~ 50 mm

  3. Turbomachine injection nozzle including a coolant delivery system

    DOE Patents [OSTI]

    Zuo, Baifang (Simpsonville, SC)

    2012-02-14T23:59:59.000Z

    An injection nozzle for a turbomachine includes a main body having a first end portion that extends to a second end portion defining an exterior wall having an outer surface. A plurality of fluid delivery tubes extend through the main body. Each of the plurality of fluid delivery tubes includes a first fluid inlet for receiving a first fluid, a second fluid inlet for receiving a second fluid and an outlet. The injection nozzle further includes a coolant delivery system arranged within the main body. The coolant delivery system guides a coolant along at least one of a portion of the exterior wall and around the plurality of fluid delivery tubes.

  4. The evaluation of melamine dendrimers as potential macromolecular vehicles for anticancer drug delivery

    E-Print Network [OSTI]

    Neerman, Michael Frederick

    2005-08-29T23:59:59.000Z

    .4. Results and discussion..........................................................35 2.4.1. In vitro evaluation .................................................35 2.4.2. Acute in vivo evaluation .......................................35... ...............................................36 16 The viability of Clone 9 cells with increasing concentrations of 1 or dextran after 24 h of exposure.......................................................................... 37 17 BUN and ALT biochemical data from the acute...

  5. Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery

    E-Print Network [OSTI]

    Snow, Merideth

    2010-07-14T23:59:59.000Z

    Breast cancer is the second leading cause of cancer deaths in women with approximately 40,000 patient deaths each year. Theranostics is an emerging area of cancer research in which chemically synthesized molecules are used to simultaneously deliver...

  6. Drug delivery systems based on sugar-macromolecule conjugates Benjamin G Davis* & Mark A Robinson

    E-Print Network [OSTI]

    Davis, Ben G.

    -Galactosamine GCR Glucocerebrosidase Glc D-Glucose GlcNAc N-Acetyl-D-glucosamine Glu Glutamate GPT Glutamic pyruvic nucleic acid PGE1 Prostaglandin E1 PVLA Poly(vinylbenzyl-lactonamide) rhIL-2 Recombinant human interleukin

  7. Development and Optimization of Polymeric Carriers for Lymphatic Imaging and Drug Delivery

    E-Print Network [OSTI]

    Bagby, Taryn Rochelle

    2011-12-31T23:59:59.000Z

    Many cancers, including melanoma and breast cancer, metastasize via the lymphatic system, a mono-directional network of vessels and nodes that parallels the circulatory system. Accurate determination of the lymph nodes ...

  8. pH-sensitive core-shell nanoparticles for intracellular drug delivery

    E-Print Network [OSTI]

    Hu, Yuhua, Ph. D. Massachusetts Institute of Technology

    2008-01-01T23:59:59.000Z

    Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis ...

  9. Bioactive and bioresponsive nanoparticle surface modifications for vaccine and systemic drug delivery

    E-Print Network [OSTI]

    Clawson, Corbin Zean

    2011-01-01T23:59:59.000Z

    core, a fusogenic DOPE/oleic acid monolayer shell, and a sterically stabilizing PEG corona.core, a fusogenic DOPE/oleic acid monolayer shell, and a sterically stabilizing PEG corona.

  10. Design, synthesis, and evaluation of dendrimers based on melamine as drug delivery vehicles

    E-Print Network [OSTI]

    Lim, Jong Doo

    2009-05-15T23:59:59.000Z

    of dendrimers (2-7) for biodistribution study .............................. 34 3.2 Pharmacokinetic data of the 125 I-radiolabled dendrimers ........................... 37 4.1 Analysis and characterization of 4a and 4b...

  11. Development of lymphatic drug delivery platforms for the treatment of carcinomas

    E-Print Network [OSTI]

    Cai, Shuang

    2011-05-31T23:59:59.000Z

    Many cancers, such as breast cancer, lung cancer, and head and neck cancer, preferentially metastasize via the lymphatic system prior to their systemic invasion. Conventional chemotherapy has limited penetration into the ...

  12. Nanostructured gene and drug delivery systems based on molecular self-assembly

    E-Print Network [OSTI]

    Wood, Kris Cameron

    2007-01-01T23:59:59.000Z

    Molecular self-assembly describes the assembly of molecular components into complex, supramolecular structures governed by weak, non-covalent interactions. In recent years, molecular self-assembly has been used extensively ...

  13. Bioactive and bioresponsive nanoparticle surface modifications for vaccine and systemic drug delivery

    E-Print Network [OSTI]

    Clawson, Corbin Zean

    2011-01-01T23:59:59.000Z

    stealth’ coatings have been developed to function in similar ways to PEG by preventing recognition of the foreign material

  14. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01T23:59:59.000Z

    Staphylococcus aureus (MRSA) growth in chronic otitis mediaco-glycolide) disc: Inhibition of MRSA(methicillin resistantco-glycolide) disc: Inhibition of MRSA(methicillin resistant

  15. Design, synthesis, and evaluation of dendrimers based on melamine as drug delivery vehicles 

    E-Print Network [OSTI]

    Lim, Jong Doo

    2009-05-15T23:59:59.000Z

    HO HO HO O O O O O O O O O O O O O O O O O O O O (d)(c) N N N N N N N N NH 2 NH 2 NH 2 NH 2 NH 2 NH 2 NH 2 NH 2 N N N N N N H 2 N H 2 N H 2 N H 2 N H 2 N H 2 N H 2 N H 2 N (a) N N HN N O H N HN N N O O OHOH HO HO O O O O HN N O N H HN N N O O OHOH HO... HO OO O O NH N O N H NH N N O O OH OH OH OH O O O O NH N O H N NH N N O O OH OH OH OH O O O O (b) N NN NH 2 N H 2 N N N N N N N N N N N N N N NN NN NN N N N N N N NH H N NH HN H N HN N N N N N NH 2 NH 2 NN N N NH 2 NH 2 N N N N N NH 2 NH 2 N N N N N N...

  16. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

    DOE Patents [OSTI]

    Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

    2014-07-22T23:59:59.000Z

    Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

  17. Fabrication of Metal/Oxide Nanostructures by Anodization Processes for Biosensor, Drug Delivery and Supercapacitor Applications

    E-Print Network [OSTI]

    Chen, Po-Chun

    2014-01-13T23:59:59.000Z

    .......................................................... 22 Figure 9 Schematic diagrams of (a) MIM capacitor and (b) electrolytic capacitor ................ 26 Figure 10 Schematic diagram of mechanism of EDLC .......................................................... 27 Figure 11 Ragone Plot [107] © SAE... ......................................................................................................................... 53 Figure 25 SEM images of UHMWPE nanotubes ................................................................... 54 Figure 26 SEM images of imprint mold; (a) pillar size of 120 nm and inter-distance of 240 nm, (b) pillar size of 160 nm and inter...

  18. A Universal Level Converter Towards the Realization of Energy Efficient Implantable Drug Delivery

    E-Print Network [OSTI]

    Mohanty, Saraju P.

    with dual- VT h technique. The robustness of the design is tested by car- rying out three types of analysis, namely: parametric, load and power. It is observed that the ULC produces a stable output for voltages as low as 0.35V and loads varying from 50fF to 120fF. The average power dissipation of the proposed level

  19. COMPUTATIONAL STUDIES OF CONTROLLED NANOPARTICLE AGGLOMERATIONS FOR MRI-GUIDED NANOROBOTIC DRUG-DELIVERY SYSTEMS

    E-Print Network [OSTI]

    Mavroidis, Constantinos

    groups have employed magnetized micro/ nanoparticles and have implemented magnetic propulsion techniques implementation is difficult and medically invasive. Finally, magnetic propulsion techniques #12;other thanEastern University Boston, MA 02115 mavro@coe.neu.edu ABSTRACT Magnetic Resonance Imaging (MRI) guided nanorobotic

  20. Fabrication of Metal/Oxide Nanostructures by Anodization Processes for Biosensor, Drug Delivery and Supercapacitor Applications 

    E-Print Network [OSTI]

    Chen, Po-Chun

    2014-01-13T23:59:59.000Z

    . Then, the microneedles were further built as an array by combining micromachining technique. The microneedle array provides a 3-D structure that possesses several hundred times more surface area and capacity than a traditional nanochannel template...

  1. Synthesis of novel polymeric nanoparticles for hydrophobic and hydrophilic drug delivery

    E-Print Network [OSTI]

    Sartor, Marta

    2010-01-01T23:59:59.000Z

    at 30?C. The mobile phase water to acetonitrile ratio 50:70 water to acetonitrile was kept constant during thestandards were in the same acetonitrile percent solution.

  2. Lymphocyte-mediated drug nanoparticle delivery to disseminated lymphoma tumors in vivo

    E-Print Network [OSTI]

    Huang, Bonnie

    2013-01-01T23:59:59.000Z

    The dissemination of lymphoma into anatomical compartments that are poorly accessible from circulation, such as lymph nodes, necessitates high doses of systemic chemotherapy. However, the potencies of many chemotherapeutic ...

  3. Macromolecular coatings on porous silicon : applications in drug delivery, biosensing, and composites

    E-Print Network [OSTI]

    Perelman, Loren Avery

    2008-01-01T23:59:59.000Z

    hybrid’ s OT returns to its original value, demonstrating the reversibility of the system through heating-system Figure 4.4 Optical thickness changes of a porous SiO 2 /poly(NIPAM) hybrid upon three consecutive heating/

  4. Nano compartments may aid drug delivery, catalyst design > Archived News

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible for Renewable Energy: GridTruck PlatooningJefferson7593 LECTIJHES ONTheStorage -

  5. Shielded beam delivery apparatus and method

    DOE Patents [OSTI]

    Hershcovitch, Ady; Montano, Rory Dominick

    2006-07-11T23:59:59.000Z

    An apparatus includes a plasma generator aligned with a beam generator for producing a plasma to shield an energized beam. An electrode is coaxially aligned with the plasma generator and followed in turn by a vortex generator coaxially aligned with the electrode. A target is spaced from the vortex generator inside a fluid environment. The electrode is electrically biased relative to the electrically grounded target for driving the plasma toward the target inside a vortex shield.

  6. Waste Feed Delivery Transfer System Analysis

    SciTech Connect (OSTI)

    JULYK, L.J.

    2000-05-05T23:59:59.000Z

    This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms.

  7. AVTA: Hybrid-Electric Delivery Vehicles

    Broader source: Energy.gov [DOE]

    The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a wide range of advanced vehicles and technologies on dynamometers, closed test tracks, and on-the-road. These results provide benchmark data that researchers can use to develop technology models and guide future research and development. The following set of reports describes data collected from testing on FedEx Express and UPS hybrid-electric delivery trucks. This research was conducted by the National Renewable Energy Laboratory (NREL).

  8. Waste feed delivery planning at Hanford

    SciTech Connect (OSTI)

    Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

    2013-01-10T23:59:59.000Z

    The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

  9. USE OF DRUG ELUTING STENTS AS A FUNCTION OF PREDICTED BENEFIT: CLINICAL AND ECONOMIC IMPLICATIONS OF CURRENT PRACTICE

    E-Print Network [OSTI]

    Amin, Amit P.

    2011-12-31T23:59:59.000Z

    Background: Benefits of drug-eluting stents (DES) in percutaneous coronary intervention (PCI) are greatest in those at the highest risk of target vessel revascularization (TVR). While DES reduce restenosis, they cost more than bare metal stents (BMS...

  10. Development of alternating amphiphilic copolymers for targeted delivery applications in cancer

    E-Print Network [OSTI]

    Brower, Kevin P. (Kevin Peter)

    2011-01-01T23:59:59.000Z

    According to the American Cancer Society, approximately 1,479,000 new cases of cancer were expected to be diagnosed, while 562,340 Americans were expected to die from cancer in 2009 alone. Even though advances in early ...

  11. Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery

    E-Print Network [OSTI]

    Pridgen, Eric M.

    Nanoparticles are poised to have a tremendous impact on the treatment of many diseases, but their broad application is limited because currently they can only be administered by parenteral methods. Oral administration of ...

  12. TARGETED BRAIN DELIVERY OF COMBINATION THERAPIES TO TREAT ACQUIRED RESISTANCE TO BRAF INHIBITORS IN METASTATIC MELANOMA

    E-Print Network [OSTI]

    Thomas, David D.

    IN METASTATIC MELANOMA Shruthi Vaidhyanthan Melanoma is a neoplasm originating in the pigment producing cells of the skin. At late stages, melanoma is a deadly disease that spreads to different organs and metastasizes with melanoma and 8,800 patients are predicted to die from the disease in the year 20121 . Brain metastases

  13. Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting

    E-Print Network [OSTI]

    Cheng, Jianjun

    /parallel synthesis that creates a large library of materials and allows identification of the best. Gabrielson, Hua Lu, Jianjun Cheng* Department of Materials Science and Engineering, University of Illinois of the gene cargos, it meanwhile causes severe associated cytotoxicities [7e9]. Excessive positive charges can

  14. Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogen and Fuel Cell Hydrogen andHydra-TH: AHybrid

  15. Realizing Technologies for Magnetized Target Fusion

    SciTech Connect (OSTI)

    Wurden, Glen A. [Los Alamos National Laboratory

    2012-08-24T23:59:59.000Z

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  16. Cooled particle accelerator target

    DOE Patents [OSTI]

    Degtiarenko, Pavel V.

    2005-06-14T23:59:59.000Z

    A novel particle beam target comprising: a rotating target disc mounted on a retainer and thermally coupled to a first array of spaced-apart parallel plate fins that extend radially inwardly from the retainer and mesh without physical contact with a second array of spaced-apart parallel plate fins that extend radially outwardly from and are thermally coupled to a cooling mechanism capable of removing heat from said second array of spaced-apart fins and located within the first array of spaced-apart parallel fins. Radiant thermal exchange between the two arrays of parallel plate fins provides removal of heat from the rotating disc. A method of cooling the rotating target is also described.

  17. Foam encapsulated targets

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

    1983-01-01T23:59:59.000Z

    Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

  18. Targeted polypeptide degradation

    DOE Patents [OSTI]

    Church, George M. (Brookline, MA); Janse, Daniel M. (Brookline, MA)

    2008-05-13T23:59:59.000Z

    This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

  19. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) Target 1 Flight Path° flightTargetL -

  20. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) Target 1 Flight Path° flightTargetL - -

  1. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) Target 1 Flight Path° flightTargetL - -

  2. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) Target 1 Flight Path° flightTargetL - - -

  3. informedRx Preferred Drug List -Effective July 1, 2012 Preferred Drug List

    E-Print Network [OSTI]

    Scharer, John E.

    informedRx Preferred Drug List - Effective July 1, 2012 Preferred Drug List Brand name drugs are listed in CAPITAL letters and generic drugs are listed in lowercase italics. Generic drugs are preferred, if available. If generic drugs are available and not listed on the formulary, but the brand name drug is

  4. Future Fixed Target Facilities

    SciTech Connect (OSTI)

    Melnitchouk, Wolodymyr

    2009-01-01T23:59:59.000Z

    We review plans for future fixed target lepton- and hadron-scattering facilities, including the 12 GeV upgraded CEBAF accelerator at Jefferson Lab, neutrino beam facilities at Fermilab, and the antiproton PANDA facility at FAIR. We also briefly review recent theoretical developments which will aid in the interpretation of the data expected from these facilities.

  5. Targeted radionuclide therapy

    SciTech Connect (OSTI)

    Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

    2008-07-15T23:59:59.000Z

    Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

  6. Solid Target Options S. Childress

    E-Print Network [OSTI]

    McDonald, Kirk

    power is higher than for existing solid target designs - but not by a large factor. · NuMI graphite beam power) · High beam power solid targets frequently use higher z materials for increased yield plusSolid Target Options NuFACT'00 S. Childress Solid Target Options · The choice of a primary beam

  7. Two-dimensional inverse planning and delivery with a preclinical image guided microirradiator

    SciTech Connect (OSTI)

    Stewart, James M. P. [Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3E2, Canada and Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9 (Canada)] [Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3E2, Canada and Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9 (Canada); Lindsay, Patricia E. [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada and Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2 (Canada)] [Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada and Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2 (Canada); Jaffray, David A. [Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3E2 (Canada) [Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3E2 (Canada); Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9 (Canada); Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2 (Canada); Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9 (Canada); The Techna Institute for the Advancement of Technology for Health, Toronto, Ontario M5G 1P5 (Canada)

    2013-10-15T23:59:59.000Z

    Purpose: Recent advances in preclinical radiotherapy systems have provided the foundation for scaling many of the elements of clinical radiation therapy practice to the dimensions and energy demanded in small animal studies. Such systems support the technical capabilities to accurately deliver highly complex dose distributions, but methods to optimize and deliver such distributions remain in their infancy. This study developed an optimization method based on empirically measured two-dimensional dose kernel measurements to deliver arbitrary planar dose distributions on a recently developed small animal radiotherapy platform.Methods: A two-dimensional dose kernel was measured with repeated radiochromic film measurements for the circular 1 mm diameter fixed collimator of the small animal radiotherapy system at 1 cm depth in a solid water phantom. This kernel was utilized in a sequential quadratic programming optimization framework to determine optimal beam positions and weights to deliver an arbitrary desired dose distribution. The positions and weights were then translated to a set of stage motions to automatically deliver the optimized dose distribution. End-to-end efficacy of the framework was quantified through five repeated deliveries of two dosimetric challenges: (1) a 5 mm radius bullseye distribution, and (2) a “sock” distribution contained within a 9 × 13 mm bounding box incorporating rectangular, semicircular, and exponentially decaying geometric constructs and a rectangular linear dose gradient region. These two challenges were designed to gauge targeting, geometric, and dosimetric fidelity.Results: Optimization of the bullseye and sock distributions required 2.1 and 5.9 min and utilized 50 and 77 individual beams for delivery, respectively. Automated delivery of the resulting optimized distributions, validated using radiochromic film measurements, revealed an average targeting accuracy of 0.32 mm, and a dosimetric delivery error along four line profiles taken through the sock distribution of 3.9%. Mean absolute delivery error across the 0–1 Gy linear dose gradient over 7.5 mm was 0.01 Gy.Conclusions: The work presented here demonstrates the potential for complex dose distributions to be planned and automatically delivered with millimeter scale heterogeneity at submillimeter accuracy. This capability establishes the technical foundation for preclinical validation of biologically guided radiotherapy investigations and development of unique radiobiological experiments.

  8. ProdrugProdrug Approach for theApproach for the Delivery ofDelivery of EstradiolEstradiol

    E-Print Network [OSTI]

    Petta, Jason

    of the anticancer drug DOX usingDOX using acetalacetal chemistry. DOX loaded micelles would release theirchemistry. DOX loaded micelles would release their drugs in a low pH environment. (drugs in a low pH environment

  9. ISAC target vacuum system

    SciTech Connect (OSTI)

    Yosifov, Dimo; Sekachev, Igor [TRIUMF, Canada's National Laboratory for Particle and Nuclear Physics, Vancouver, British Columbia V6T 2A3 (Canada)

    2006-07-15T23:59:59.000Z

    The Isotope Separator and Accelerator (ISAC) facility at TRIUMF has been in full operation since 1999. The ISAC east and west targets use proton beam from the cyclotron to produce various radioactive isotopes, which are then ionized and extracted. The ions are then passed through the mass separator and selected ions are transferred to the low energy experiments or injected into a radio frequency quadrupole accelerator. The accompanying radioactive contamination from the production of radioactive ions requires a complex vacuum system. The main target vacuum space consists of two semiseparate (primary and secondary) volumes pumped by turbo-molecular pumps. The primary volume uses four pumps while the secondary volume uses two pumps. Two hermetic rotary vane pumps are used as backing pumps. The nominal vacuum in both volumes is about 1.33x10{sup -4} Pa (1.0x10{sup -6} Torr). The pressure is monitored by two cold cathode and two hot filament ion gauges. The cold cathode gauges are used to interlock the system, which is critical during the bake out of the target and beam production. The exhaust gas from the vacuum pumps can be radioactive. Three gas storage tanks (decay tanks) are used for temporary storage of the radioactive exhaust and its controlled release to the atmosphere. Gas-species insensitive membrane gauges are used for monitoring the pressure in the storage tanks. This article describes the details of the ISAC target vacuum system as well as some procedures related to the handling of the exhaust gas with traces of radioactive contamination produced by the targets.

  10. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    . A battery of in vitro assays readily distinguishes between DNA intercalation, DNA groove binding-targeting drugs for cancer and beyond, the further discovery and characterization of such compounds are of considerable interest. This review outlines diagnostic experiments useful in characterizing noncovalent drug

  11. Targeting Cancer More Effectively CR@B brings together researchers from across the University and the Royal United Hospital, Bath.

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Targeting Cancer More Effectively CR@B brings together researchers from across the University to find a cure for various types of cancer. 40 academic groups from nearly every department to bedside and back again. Drug Discovery The discovery of a new family of anti-cancer drugs called steroid

  12. Drug metabolizing enzymes activities versus genetic variances for drug of clinical pharmacogenomic relevance

    E-Print Network [OSTI]

    Wu, Alan HB

    2011-01-01T23:59:59.000Z

    this article as: Wu: Drug metabolizing enzyme activitiesgenetic variances for drug of clinical pharmacogenomicPROTEOMICS Open Access Drug metabolizing enzyme activities

  13. Real time sensor for therapeutic radiation delivery

    DOE Patents [OSTI]

    Bliss, Mary (West Richland, WA); Craig, Richard A. (West Richland, WA); Reeder, Paul L. (Richland, WA)

    1998-01-01T23:59:59.000Z

    The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body.

  14. Real time sensor for therapeutic radiation delivery

    DOE Patents [OSTI]

    Bliss, M.; Craig, R.A.; Reeder, P.L.

    1998-01-06T23:59:59.000Z

    The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body. 14 figs.

  15. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)IntegratedSpeedingTechnicalPurchase, Delivery, and Storage of Gases Print ALS users

  16. 2013 Revenue for Delivery Service Providers

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghurajiConventionalMississippi" ,"Plant","Primary1. TotalRevenue for Delivery Service

  17. Vectren Energy Delivery of Indiana (Gas)- Commercial Energy Efficiency Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers commercial natural gas customers in Indiana rebates for the installation of certain types of efficient natural gas equipment. Prescriptive equipment rebates are...

  18. alternative delivery systems: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delivery: An Option to Ease the Transition Renewable Energy Websites Summary: and refining industries Current natural gas infrastructure consists of: - Pipelines -...

  19. Office of Electricity Delivery and Energy Reliability Cyber Security...

    Energy Savers [EERE]

    the Nation's Energy Infrastructure from Cyber Attacks Working to Achieve Cybersecurity in the Energy Sector Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011...

  20. Office of Electricity Delivery & Energy Reliability FY 2012 Budget...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Presentation by Patricia Hoffman of...

  1. Lighting and Electrical Team Leadership and Project Delivery...

    Broader source: Energy.gov (indexed) [DOE]

    Linda Sandahl, Pacific Northwest National Laboratory Learn More Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO Peer Review Presentation More Documents &...

  2. Vectren Energy Delivery of Ohio (Gas)- Residential Energy Efficiency Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers residential natural gas customers in Ohio rebates for the installation of certain high efficiency natural gas appliances and building insulation. Rebates are...

  3. Determining the lowest-cost hydrogen delivery mode

    E-Print Network [OSTI]

    Yang, Christopher; Ogden, Joan M

    2007-01-01T23:59:59.000Z

    costs to estimate hydrogen pipeline costs. Davis, CA: ITS-hydrogen. The cost of hydrogen pipeline delivery de- pendshydrogen trucks, and hydrogen pipelines, were devel- oped

  4. H2A Delivery Components Model and Analysis

    Broader source: Energy.gov (indexed) [DOE]

    forms Storage Components Delivery Components -Compressed Gas Tube System -Bulk Liquid Hydrogen System -Geologic -Forecourt -Truck - Tube Trailer -Truck - LH2 -Pipeline...

  5. Vectren Energy Delivery of Indiana (Gas)- Residential Energy Efficiency Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers its residential natural gas customers in Indiana rebates for the installation of certain high efficiency natural gas appliances and insulation measures. Rebates are...

  6. ,"New Mexico Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,,"(202) 586-8800",,,"3292015 10:05:26 PM" "Back to Contents","Data 1: New Mexico Natural Gas Deliveries to Electric Power Consumers (MMcf)"...

  7. 2012 Director's Science Delivery Award | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SHARE 2012 Director's Science Delivery Award June 24, 2013 CSMD Researcher Forrest Hoffman (along with ORNL researchers Jitendra Kumar and Richard Mills), is on the team that...

  8. Hydrogen Delivery Technologies and Systems- Pipeline Transmission of Hydrogen

    Broader source: Energy.gov [DOE]

    Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen. Design and operations standards and materials for hydrogen and natural gas pipelines.

  9. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Environmental Management (EM)

    Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the...

  10. Office of Electricity Delivery and Energy Reliability | Department...

    Broader source: Energy.gov (indexed) [DOE]

    & Internships Funding Opportunities Information Center Contact Us Energy.gov Office of Electricity Delivery & Energy Reliability 1000 Independence Avenue, SW Washington, DC...

  11. Liquid Hydrogen Production and Delivery from a Dedicated Wind...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    a Dedicated Wind Power Plant Liquid Hydrogen Production and Delivery from a Dedicated Wind Power Plant This May 2012 study assesses the costs and potential for remote renewable...

  12. Cost comparison of collaborative and IPD-like project delivery methods versus non-collaborative project delivery methods

    E-Print Network [OSTI]

    Kulkarni, Aditi; Rybkowski, Zofia K.; Smith, James

    2012-07-17T23:59:59.000Z

    Proceedings of the 20th Conference of the International Group for Lean Construction July 17-22, 2012: San Diego, CA, U.S.A. 781 COST COMPARISON OF COLLABORATIVE AND IPD-LIKE PROJECT DELIVERY METHODS VERSUS COMPETITIVE NON... acceptance of IPD for public projects. KEYWORDS Collaboration, Project Delivery, CM-at-Risk (CMR; CMAR), Competitive Sealed Proposal (CSP), Integrated Project Delivery (IPD), Design-Bid-Build (DBB), Cost Comparison INTRODUCTION One of the most widely...

  13. The University of New Mexico An NSF Integrative Graduate

    E-Print Network [OSTI]

    New Mexico, University of

    in INCBN IGERT Seminar Location: Room 101, Center for High Technology Materials (CHTM) 1313 Goddard SE SW drug delivery methods (including passive targeting of "stealth" nanoparticles and receptor

  14. Somatic mutations in PI3K[alpha]: Structural basis for enzyme activation and drug design

    SciTech Connect (OSTI)

    Gabelli, Sandra B.; Mandelker, Diana; Schmidt-Kittler, Oleg; Vogelstein, Bert; Amzel, L. Mario (JHU); (HHMI)

    2011-09-06T23:59:59.000Z

    The PI3K pathway is a communication hub coordinating critical cell functions including cell survival, cell growth, proliferation, motility and metabolism. Because PI3K{alpha} harbors recurrent somatic mutations resulting in gains of function in human cancers, it has emerged as an important drug target for many types of solid tumors. Various PI3K isoforms are also being evaluated as potential therapeutic targets for inflammation, heart disease, and hematological malignancies. Structural biology is providing insights into the flexibility of the PI3Ks, and providing basis for understanding the effects of mutations, drug resistance and specificity.

  15. Somatic Mutations in PI3Kalpha: Structural Basis for Enzyme Activation and Drug Design

    SciTech Connect (OSTI)

    S Gabelli; D Mandelker; O Schmidt-Kittler; B Vogelstein; L Amzel

    2011-12-31T23:59:59.000Z

    The PI3K pathway is a communication hub coordinating critical cell functions including cell survival, cell growth, proliferation, motility and metabolism. Because PI3K{alpha} harbors recurrent somatic mutations resulting in gains of function in human cancers, it has emerged as an important drug target for many types of solid tumors. Various PI3K isoforms are also being evaluated as potential therapeutic targets for inflammation, heart disease, and hematological malignancies. Structural biology is providing insights into the flexibility of the PI3Ks, and providing basis for understanding the effects of mutations, drug resistance and specificity.

  16. Inexpensive delivery of compressed hydrogen with advanced vessel technology

    E-Print Network [OSTI]

    of flexible refueling (compressed/cryogenic H2/(L)H2) #12;The PVT properties of H2 drive storage and delivery) Explore station demand from 70 kg H2/day to 1000 kg H2/day · Real hydrogen thermodynamic and PVT diagram and vessel characteristics to minimize delivery cost · Hydrogen and material properties Increased

  17. A PRIORITY-BASED ADAPTIVE SCHEME FOR WIRELESS MULTIMEDIA DELIVERY

    E-Print Network [OSTI]

    A PRIORITY-BASED ADAPTIVE SCHEME FOR WIRELESS MULTIMEDIA DELIVERY Edward Casey and Gabriel, Dublin 9, Ireland Email: {caseye, munteang}@eeng.dcu.ie ABSTRACT In wireless multimedia streaming proposes a priority-based wireless adaptive multimedia delivery scheme that enables client prioritisation

  18. Optimal Power Management for a Hydraulic Hybrid Delivery Truck

    E-Print Network [OSTI]

    Peng, Huei

    Optimal Power Management for a Hydraulic Hybrid Delivery Truck BIN WU, CHAN-CHIAO LIN, ZORAN FILIPI control strategies. This paper presents a methodology for developing a power management strategy tailored specifically to a parallel Hydraulic Hybrid Vehicle (HHV) configured for a medium-size delivery truck

  19. Distributed Power Delivery for Energy Efficient and Low Power Systems

    E-Print Network [OSTI]

    Friedman, Eby G.

    Distributed Power Delivery for Energy Efficient and Low Power Systems Selc¸uk K¨ose Department throughout a power distribution system. Due to the parasitic impedances of the power distribution networks current to the load circuits [3]. The complexity of the high performance power delivery systems has

  20. Rethinking America’s Illegal Drug Policy

    E-Print Network [OSTI]

    Donohue III, John J.

    2011-01-01T23:59:59.000Z

    2006. “The Market for Illegal Goods: The Case of Drugs. ”Informing America’s Policy on Illegal Drugs: What We Don’tViewpoints. Should Illegal Drugs Be Decriminalized? ” In

  1. A planning and delivery study of a rotational IMRT technique with burst delivery

    SciTech Connect (OSTI)

    Kainz, Kristofer; Chen, Guang-Pei; Chang, Yu-Wen; Prah, Douglas; Sharon Qi, X.; Shukla, Himanshu P.; Stahl, Johannes; Allen Li, X. [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States); Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado 80045 (United States); Siemens Oncology Care Systems, Concord, California 94520 (United States); Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States)

    2011-09-15T23:59:59.000Z

    Purpose: A novel rotational IMRT (rIMRT) technique using burst delivery (continuous gantry rotation with beam off during MLC repositioning) is investigated. The authors evaluate the plan quality and delivery efficiency and accuracy of this dynamic technique with a conventional flat 6 MV photon beam. Methods: Burst-delivery rIMRT was implemented in a planning system and delivered with a 160-MLC linac. Ten rIMRT plans were generated for five anonymized patient cases encompassing head and neck, brain, prostate, and prone breast. All plans were analyzed retrospectively and not used for treatment. Among the varied plan parameters were the number of optimization points, number of arcs, gantry speed, and gantry angle range (alpha) over which the beam is turned on at each optimization point. Combined rotational/step-and-shoot rIMRT plans were also created by superimposing multiple-segment static fields at several optimization points. The rIMRT trial plans were compared with each other and with plans generated using helical tomotherapy and VMAT. Burst-mode rotational IMRT plans were delivered and verified using a diode array, ionization chambers, thermoluminescent dosimeters, and film. Results: Burst-mode rIMRT can achieve plan quality comparable to helical tomotherapy, while the former may lead to slightly better OAR sparing for certain cases and the latter generally achieves slightly lower hot spots. Few instances were found in which increasing the number of optimization points above 36, or superimposing step-and-shoot IMRT segments, led to statistically significant improvements in OAR sparing. Using an additional rIMRT partial arc yielded substantial OAR dose improvements for the brain case. Measured doses from the rIMRT plan delivery were within 4% of the plan calculation in low dose gradient regions. Delivery time range was 228-375 s for single-arc rIMRT 200-cGy prescription with a 300 MU/min dose rate, comparable to tomotherapy and VMAT. Conclusions: Rotational IMRT with burst delivery, whether combined with static fields or not, yields clinically acceptable and deliverable treatment plans.

  2. Target: Subpoena (2010-SE-2001)

    Broader source: Energy.gov [DOE]

    DOE issued a Subpoena for Information and Production of Documents to Target Corporation requesting information regarding the compliance of various torchieres Target has distributed in commerce in the U.S.

  3. Non-PGM Target Update

    Broader source: Energy.gov (indexed) [DOE]

    targets that need to be met are cost, efficiency, and durability. A secondary target is heat rejection at rated power. (ANL) * Given that for current Pt systems catalyst cost is ...

  4. Target | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries PvtStratosolar Jump to:Holdings Co08.0Information ExpansionTarget GmbH Jump

  5. Optical diagnostics integrated with laser spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

    2008-09-02T23:59:59.000Z

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  6. Cancer Cell Targeting Androgen Receptor

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    in the development of endo- crine therapies targeting estrogen production or ER for both breast cancer treatment targeting of AR, Wnt or HER2 signaling impairs androgen-stimulated tumor cell growth suggesting potential. Therapies targeting HER2 such as trastuzumab are becoming increasingly important in the treatment of HER2

  7. Rotating Target Development for SNS Second Target Station

    SciTech Connect (OSTI)

    McManamy, Thomas J [ORNL; Rennich, Mark J [ORNL; Crawford, Roy K [ORNL; Geoghegan, Patrick J [ORNL; Janney, Jim G [ORNL

    2010-01-01T23:59:59.000Z

    A rotating target for the second target station (STS) at SNS has been identified as an option along with a mercury target. Evaluation of the rotating target alternative for STS has started at 1.5 MW which is considered an upper bound for the power. Previous preconceptual design work for a 3 MW rotating target is being modified for the lower power level. Transient thermal analysis for a total loss of active water cooling has been done for a simplified 2D model of the target and shielding monolith which shows that peak temperatures are well below the level at which tungsten vaporization by steam could exceed site boundary dose limits. Design analysis and integration configuration studies have been done for the target-moderator-reflector assembly which maximizes the number of neutron beam lines and provides for replacement of the target and moderators. Target building hot cell arrangement for this option will be described. An option for operation in rough vacuum without a proton beam window using Ferro fluid seals on a vertical shaft is being developed. A full scale prototypic drive module based on the 3 MW preconceptual design has been fabricated and successfully tested with a shaft and mock up target supplied by the ESS-Bilbao team. Overall planning leading to decision between mercury and the rotating target in 2011 will be discussed

  8. Joint Meeting on Hydrogen Delivery Modeling and Analysis FreedomCAR and Fuels Partnership Hydrogen Delivery, Storage and

    E-Print Network [OSTI]

    . ­ The current capital costs for the hydrogen pipelines in the model are based on 1.1X the price of steel naturalJoint Meeting on Hydrogen Delivery Modeling and Analysis FreedomCAR and Fuels Partnership Hydrogen be prioritized) by mid-2008 H2A Delivery Model: Discussion Items, Comments, and Follow-up Actions 1. Pipeline

  9. U.S. Department of Energy Office of Electricity Delivery & Energy...

    Energy Savers [EERE]

    U.S. Department of Energy Office of Electricity Delivery & Energy Reliability: Transmission Reliability Program U.S. Department of Energy Office of Electricity Delivery & Energy...

  10. anti-hiv sirna delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

  11. adenovirus-mediated gene delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12;Hydrogen Delivery Options Gaseous hydrogen - Pipelines, corrosion Gaseous hydrogen pipeline delivery program would share similar technology R&D areas novel pigs to...

  12. aav-mediated intramuscular delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Painter, Kevin 24 Hydrogen Delivery Mark Paster Renewable Energy Websites Summary: Hydrogen Delivery Goal LiquidH2&Chem.CarriersGaseous Pipeline Truck Hydrides Liquid H2 -...

  13. E-Print Network 3.0 - advocates expanded delivery Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    POLICY AND MANAGEMENT JULY 14, 2010 Summary: DELIVERY SYSTEM REDESIGN The US health care delivery system is expensive, fragmented, highly decentralized... , efficient, and...

  14. Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen

    Broader source: Energy.gov [DOE]

    Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen.Solid and liquid hydrogen carriers for use in hydrogen storage and delivery.

  15. Target detection portal

    DOE Patents [OSTI]

    Linker, Kevin L. (Albuquerque, NM); Brusseau, Charles A. (Tijeras, NM)

    2002-01-01T23:59:59.000Z

    A portal apparatus for screening persons or objects for the presence of trace amounts of target substances such as explosives, narcotics, radioactive materials, and certain chemical materials. The portal apparatus can have a one-sided exhaust for an exhaust stream, an interior wall configuration with a concave-shape across a horizontal cross-section for each of two facing sides to result in improved airflow and reduced washout relative to a configuration with substantially flat parallel sides; air curtains to reduce washout; ionizing sprays to collect particles bound by static forces, as well as gas jet nozzles to dislodge particles bound by adhesion to the screened person or object. The portal apparatus can be included in a detection system with a preconcentrator and a detector.

  16. PDFs for nuclear targets

    E-Print Network [OSTI]

    Karol Kovarik

    2010-06-25T23:59:59.000Z

    Understanding nuclear effects in parton distribution functions (PDF) is an essential component needed to determine the strange and anti-strange quark contributions in the proton. In addition Nuclear Parton Distribution Functions (NPDF) are critically important for any collider experiment with nuclei (e.g. RHIC, ALICE). Here two next-to-leading order chi^2-analyses of NPDF are presented. The first uses neutral current charged-lepton Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DIS data. We compare the nuclear corrections factors (F_2^Fe/F_2^D) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.

  17. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, David J. (Fremont, CA); Anex, Deon S. (Livermore, CA); Yan, Chao (Pleasanton, CA); Dadoo, Rajeev (Stanford, CA); Zare, Richard N. (Stanford, CA)

    1999-01-01T23:59:59.000Z

    Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

  18. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, D.J.; Anex, D.S.; Yan, C.; Dadoo, R.; Zare, R.N.

    1999-08-24T23:59:59.000Z

    Method and apparatus are disclosed for controlling precisely the composition and delivery of liquid at sub-{micro}L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-{micro}L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column. 4 figs.

  19. Bounding Radionuclide Inventory and Accident Consequence Calculation for the 1L Target

    SciTech Connect (OSTI)

    Kelsey, Charles T. IV [Los Alamos National Laboratory

    2011-01-01T23:59:59.000Z

    A bounding radionuclide inventory for the tungsten of the Los Alamos Neutron Science Center (LANSCE) IL Target is calculated. Based on the bounding inventory, the dose resulting from the maximum credible incident (MCI) is calculated for the maximally exposed offsite individual (MEOl). The design basis accident involves tungsten target oxidation following a loss of cooling accident. Also calculated for the bounding radionuclide inventory is the ratio to the LANSCE inventory threshold for purposes of inventory control as described in the target inventory control policy. A bounding radionuclide inventory calculation for the lL Target was completed using the MCNPX and CINDER'90 codes. Continuous beam delivery at 200 {micro}A to 2500 mA{center_dot}h was assumed. The total calculated activity following this irradiation period is 205,000 Ci. The dose to the MEOI from the MCI is 213 mrem for the bounding inventory. The LANSCE inventory control threshold ratio is 132.

  20. Telerobotic system concept for real-time soft-tissue imaging during radiotherapy beam delivery

    SciTech Connect (OSTI)

    Schlosser, Jeffrey; Salisbury, Kenneth; Hristov, Dimitre [Department of Mechanical Engineering, Stanford University, Stanford, California 94305 (United States); Department of Computer Science and Department of Surgery, Stanford University, Stanford, California 94305 (United States); Department of Radiation Oncology, Stanford University, Stanford, California 94305 (United States)

    2010-12-15T23:59:59.000Z

    Purpose: The curative potential of external beam radiation therapy is critically dependent on having the ability to accurately aim radiation beams at intended targets while avoiding surrounding healthy tissues. However, existing technologies are incapable of real-time, volumetric, soft-tissue imaging during radiation beam delivery, when accurate target tracking is most critical. The authors address this challenge in the development and evaluation of a novel, minimally interfering, telerobotic ultrasound (U.S.) imaging system that can be integrated with existing medical linear accelerators (LINACs) for therapy guidance. Methods: A customized human-safe robotic manipulator was designed and built to control the pressure and pitch of an abdominal U.S. transducer while avoiding LINAC gantry collisions. A haptic device was integrated to remotely control the robotic manipulator motion and U.S. image acquisition outside the LINAC room. The ability of the system to continuously maintain high quality prostate images was evaluated in volunteers over extended time periods. Treatment feasibility was assessed by comparing a clinically deployed prostate treatment plan to an alternative plan in which beam directions were restricted to sectors that did not interfere with the transabdominal U.S. transducer. To demonstrate imaging capability concurrent with delivery, robot performance and U.S. target tracking in a phantom were tested with a 15 MV radiation beam active. Results: Remote image acquisition and maintenance of image quality with the haptic interface was successfully demonstrated over 10 min periods in representative treatment setups of volunteers. Furthermore, the robot's ability to maintain a constant probe force and desired pitch angle was unaffected by the LINAC beam. For a representative prostate patient, the dose-volume histogram (DVH) for a plan with restricted sectors remained virtually identical to the DVH of a clinically deployed plan. With reduced margins, as would be enabled by real-time imaging, gross tumor volume coverage was identical while notable reductions of bladder and rectal volumes exposed to large doses were possible. The quality of U.S. images obtained during beam operation was not appreciably degraded by radiofrequency interference and 2D tracking of a phantom object in U.S. images obtained with the beam on/off yielded no significant differences. Conclusions: Remotely controlled robotic U.S. imaging is feasible in the radiotherapy environment and for the first time may offer real-time volumetric soft-tissue guidance concurrent with radiotherapy delivery.

  1. DRUG STUDY QUESTIONNAIRE PROGRAM DIRECTOR:______________________________________ DATE:_____________________________

    E-Print Network [OSTI]

    Acton, Scott

    DRUG STUDY QUESTIONNAIRE PROGRAM DIRECTOR:______________________________________ DATE and/or efficacy of a drug? A. If yes, is the testing, study, evaluation or research primarily for use in pharmaceutical pre-market clearance applications to the Food and Drug Administration? 2. Is drug administered

  2. Evotec has teamed up with the Harwell Imaging Partnership (HIP) to maximise the potential of their research into cancer treatment drugs

    E-Print Network [OSTI]

    Zharkova, Valentina V.

    of their research into cancer treatment drugs using the Science and Technology Facilities Council (STFC)'s Central-based cancer treatments work by inhibiting the signals that cause mutated cancer cells to divide and multiply to the treatment. The ability to conduct single-cell imaging of inhibitor drugs binding their target in cancer

  3. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, Douglas N. (Knoxville, TN)

    1996-01-01T23:59:59.000Z

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  4. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, D.N.

    1996-01-09T23:59:59.000Z

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  5. HAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC OTHER HAZARDOUS DRUGS IN CLINICAL ENVIRONMENTS

    E-Print Network [OSTI]

    Kim, Duck O.

    containers, pickup hazardous drug waste and provide chemo spill kits to appropriate areas. The OfficeHAZARDOUS DRUG SAFETY AND HEALTH PLAN FOR HANDLING ANTINEOPLASTIC AND OTHER HAZARDOUS DRUGS, administration and disposal of drug residues. Drugs are classified as hazardous if studies in animals and

  6. Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates

    E-Print Network [OSTI]

    Cheng, Jianjun

    Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates to paclitaxel and the subsequent ring-opening polymerization of lactide. The drug-initiated, controlled(-caprolactone)) was also achieved through drug/(BDI-II)ZnN(TMS)2-mediated controlled polymerization. These drug

  7. ForPeerReview Drug user dynamics: a compartmental model of drug users

    E-Print Network [OSTI]

    Triolo, Livio

    ForPeerReview Only Drug user dynamics: a compartmental model of drug users for scenario analyses Journal: Drugs: Education, Prevention & Policy Manuscript ID: CDEP-2012-0094.R1 Manuscript Type: Original papers Keywords: Drug use, Epidemics, Compartmental modeling, Scenario analysis, Evaluation, Drug policy

  8. Water delivery in the Early Solar System

    E-Print Network [OSTI]

    Dvorak, Rudolf; Süli, Áron; Sándor, Zsolt; Galiazzo, Mattia; Pilat-Lohinger, Elke

    2015-01-01T23:59:59.000Z

    As part of the national scientific network 'Pathways to Habitable Worlds' the delivery of water onto terrestrial planets is a key question since water is essential for the development of life as we know it. After summarizing the state of the art we show some first results of the transport of water in the early Solar System for scattered main belt objects. Hereby we investigate the questions whether planetesimals and planetesimal fragments which have gained considerable inclination due to the strong dynamical interactions in the main belt region around 2 AU can be efficient water transporting vessels. The Hungaria asteroid group is the best example that such scenarios are realistic. Assuming that the gas giants and the terrestrial planets are already formed, we monitor the collisions of scattered small bodies containing water (in the order of a few percent) with the terrestrial planets. Thus we are able to give a first estimate concerning the respective contribution of such bodies to the actual water content i...

  9. Target Space Duality III: Potentials

    E-Print Network [OSTI]

    Orlando Alvarez; Blazej Ruszczycki

    2007-12-31T23:59:59.000Z

    We generalize previous results on target space duality to the case where there are background fields and the sigma model lagrangian has a potential function.

  10. Joint Meeting on Hydrogen Delivery Modeling and Analysis, May...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    up to 2 truck deliveries per day realizing this may be a stretch. 4. Refueling site compressors: how many and what reliability? Follow-up: Change to 3 @ 50% especially considering...

  11. Delivery optimization for a make to order custom wire mill

    E-Print Network [OSTI]

    Slivinskiy, Andrey L

    2005-01-01T23:59:59.000Z

    In the face of growing competition in the Tantalum business, H.C.Starck's management is minimizing the delivery time for custom-made capacitor-grade tantalum wire products. H.C. Starck, Inc., Newton, Massachusetts faces ...

  12. Lamont Jackson Office of Electricity Delivery and Energy Reliability

    Energy Savers [EERE]

    March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C. 20585...

  13. Vectren Energy Delivery of Ohio (Gas)- Energy Star Home Rebate

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery of Ohio offers a flat rebate to builders of residential single-family Energy Star certified homes that receive gas service from the company. In order to qualify, homes must...

  14. Vacancy Announcements Posted for Hydrogen Production and Delivery Program

    Broader source: Energy.gov [DOE]

    The Fuel Cell Technologies Office has posted two vacancy announcements for a position to serve as Program Manager for the Hydrogen Production and Delivery Program in the DOE EERE Fuel Cell Technologies Office. The closing date is October 28, 2014.

  15. Hydrogen Delivery Technologies and Pipeline Transmission of Hydrogen

    E-Print Network [OSTI]

    Hydrogen Delivery Technologies and Systems Pipeline Transmission of Hydrogen Strategic Initiatives, and Infrastructure Technologies Program #12;Pipeline Transmission of Hydrogen --- 2 Copyright: Design & Operation development) #12;Pipeline Transmission of Hydrogen --- 3 Copyright: Future H2 Infrastructure Wind Powered

  16. Determining the Lowest-Cost Hydrogen Delivery Mode

    E-Print Network [OSTI]

    Yang, Christopher; Ogden, Joan M

    2008-01-01T23:59:59.000Z

    Costs to Estimate Hydrogen Pipeline Costs. 2004, ITS-Davis:hydrogen. The cost of hydrogen pipeline delivery depends onCosts to Estimate Hydrogen Pipeline Costs. 2004, ITS-Davis:

  17. Product & customer profiling for Direct Store Delivery (DSD)

    E-Print Network [OSTI]

    Chen, Liang, M. Eng. Massachusetts Institute of Technology

    2008-01-01T23:59:59.000Z

    This thesis is to analyze the suitability of different products, suppliers and customers for Direct Store Delivery (DSD) model with respect to the qualitative profile and the quantitative benefits. During the research, ...

  18. Vehicle Technologies Office - AVTA: All Electric Delivery Trucks...

    Energy Savers [EERE]

    of reports (part of the medium and heavy-duty truck data) describes data collected from Smith Newton all-electric delivery trucks in a variety of fleets. This research was...

  19. Design of an underwater vertical glider for subsea equipment delivery

    E-Print Network [OSTI]

    Ambler, Charles Kirby

    2010-01-01T23:59:59.000Z

    Delivery of subsea equipment and sensors is generally accomplished with unguided sinking platforms or powered autonomous underwater vehicles (AUVs). An alternative would be to augment existing platforms with navigation and ...

  20. DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project...

    Broader source: Energy.gov (indexed) [DOE]

    the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting at Argonne National Laboratory. The purpose of the meeting was to review the progress and plans...

  1. Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions

    E-Print Network [OSTI]

    Macdonald, Mara Lee

    2010-01-01T23:59:59.000Z

    This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer ...

  2. Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

    E-Print Network [OSTI]

    Sharei, Armon Reza

    Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This technology has shown potential in addressing previously challenging ...

  3. A vector-free microfluidic platform for intracellular delivery

    E-Print Network [OSTI]

    Sharei, Armon Reza

    Intracellular delivery of macromolecules is a challenge in research and therapeutic applications. Existing vector-based and physical methods have limitations, including their reliance on exogenous materials or electrical ...

  4. ,"New York Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,,"(202) 586-8800",,,"2262015 9:13:19 AM" "Back to Contents","Data 1: New York Natural Gas Deliveries to Electric Power Consumers (MMcf)" "Sourcekey","N3045NY2"...

  5. aid food delivery: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Hu, Terry 2011-01-01 15 Draft 1.0 Measuring progress with tests of learning: Pros and Cons for Cash on Delivery Aid in Education 1 CiteSeer Summary: This paper...

  6. Scalable Analysis, Verification and Design of IC Power Delivery

    E-Print Network [OSTI]

    Zeng, Zhiyu

    2012-02-14T23:59:59.000Z

    Due to recent aggressive process scaling into the nanometer regime, power delivery network design faces many challenges that set more stringent and specific requirements to the EDA tools. For example, from the perspective of analysis, simulation...

  7. Managing Faults in the Service Delivery Process of Service Provider Coalitions Patricia Marcu

    E-Print Network [OSTI]

    processes of ITSM are critical for successful delivery as stressed by the IT Infrastructure Library (ITIL

  8. Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery (Presentation)

    SciTech Connect (OSTI)

    Jalalzadeh-Azar, A.

    2010-10-18T23:59:59.000Z

    This presentation summarizes "A Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery".

  9. Providing ordered message delivery in communication network systems

    E-Print Network [OSTI]

    Rivera-Hernandez, Julio A

    1995-01-01T23:59:59.000Z

    PROVIDING ORDERED MESSAGE DELIVERY IN COMMUNICATION NETWORK SYSTEMS A Thesis by JULI0 A. RIVERA-HERNANDEZ Submitted to the Oflice of Graduate Studies of Texas AkM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1995 Major Subject: Computer Science PROVIDING ORDERED MESSAGE DELIVERY IN COMMUNICATION NETWORK SYSTEMS A Thesis by JULIO A. RIVERA-HERNANDEZ Submitted to Texas ARM University in partial fulfillment of the requirements for the degree...

  10. Hydraulic Hybrid Parcel Delivery Truck Deployment, Testing & Demonstration

    SciTech Connect (OSTI)

    Gallo, Jean-Baptiste

    2014-03-31T23:59:59.000Z

    Although hydraulic hybrid systems have shown promise over the last few years, commercial deployment of these systems has primarily been limited to Class 8 refuse trucks. In 2005, the Hybrid Truck Users Forum initiated the Parcel Delivery Working Group including the largest parcel delivery fleets in North America. The goal of the working group was to evaluate and accelerate commercialization of hydraulic hybrid technology for parcel delivery vehicles. FedEx Ground, Purolator and United Parcel Service (UPS) took delivery of the world’s first commercially available hydraulic hybrid parcel delivery trucks in early 2012. The vehicle chassis includes a Parker Hannifin hydraulic hybrid drive system, integrated and assembled by Freightliner Custom Chassis Corp., with a body installed by Morgan Olson. With funding from the U.S. Department of Energy, CALSTART and its project partners assessed the performance, reliability, maintainability and fleet acceptance of three pre-production Class 6 hydraulic hybrid parcel delivery vehicles using information and data from in-use data collection and on-road testing. This document reports on the deployment of these vehicles operated by FedEx Ground, Purolator and UPS. The results presented provide a comprehensive overview of the performance of commercial hydraulic hybrid vehicles in parcel delivery applications. This project also informs fleets and manufacturers on the overall performance of hydraulic hybrid vehicles, provides insights on how the technology can be both improved and more effectively used. The key findings and recommendations of this project fall into four major categories: ? Performance, ? Fleet deployment, ? Maintenance, ? Business case. Hydraulic hybrid technology is relatively new to the market, as commercial vehicles have been introduced only in the past few years in refuse and parcel delivery applications. Successful demonstration could pave the way for additional purchases of hydraulic hybrid vehicles throughout the trucking industry. By providing unbiased, third-party assessment of this “hybrid without batteries” technology, this report offers relevant, timely and valuable information to the industry.

  11. Delivery system for molten salt oxidation of solid waste

    DOE Patents [OSTI]

    Brummond, William A. (Livermore, CA); Squire, Dwight V. (Livermore, CA); Robinson, Jeffrey A. (Manteca, CA); House, Palmer A. (Walnut Creek, CA)

    2002-01-01T23:59:59.000Z

    The present invention is a delivery system for safety injecting solid waste particles, including mixed wastes, into a molten salt bath for destruction by the process of molten salt oxidation. The delivery system includes a feeder system and an injector that allow the solid waste stream to be accurately metered, evenly dispersed in the oxidant gas, and maintained at a temperature below incineration temperature while entering the molten salt reactor.

  12. Drug Trafficking Organizations and Counter-Drug Strategies in the U.S.-Mexican Context

    E-Print Network [OSTI]

    Astorga, Luis; Shirk, David A.

    2010-01-01T23:59:59.000Z

    Analytic Assessment of U.S. Drug Policy. Washington, D.C. ,K. (2008). Mexico Faces New Drug Challenge: Mini-Submarines.Mayors on Front Line of the Drug War. Los Angeles Times Los

  13. Target Proposal Feb. 15, 2000

    E-Print Network [OSTI]

    McDonald, Kirk

    enables simpler system design, compatible with high magnetic field, no toxic waste, replaceable option initial approach can be very important in progress toward a real facility #12; Target Proposal Feb. 15 Target Survivability (cont) . Cooling ­ 23 kW per MW of beam power -- A significant advantage of carbon

  14. VERTEX CHAMBERS TARGET CELL CALORIMETER

    E-Print Network [OSTI]

    DRIFT VC 1/2 FC 1/2 VERTEX CHAMBERS TARGET CELL DVC MC 1­3 HODOSCOPE H0 MONITOR BC 1/2 BC 3/4 TRD at Threashold Lambda Physics (u ­L spin transfer) Motivation: ­ W L Target cell e beam L p p e ­ Elastic: Peltier elements ( T ~ ­20C ) ­ Custom built electronics + HELIX chips low autgassing (

  15. High Power Hg Target Conceptual Design Review

    E-Print Network [OSTI]

    McDonald, Kirk

    LABORATORY U. S. DEPARTMENT OF ENERGY Conceptual Design Review 7-8 Feb 05 System Overview Solenoid Proton Alternative Hg Delivery System Hydraulic Fluid Cylinder (3000 psi) Hg Cylinder (1000 psi) Hg Discharge Hg concept & issues · Proposed new baseline delivery system · Hg flow analysis in new baseline system

  16. Id-1 and Id-2 genes and products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    SciTech Connect (OSTI)

    Desprez, Pierre-Yves; Campisi, Judith

    2014-09-30T23:59:59.000Z

    A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.

  17. Drug testing example for conditional probability Suppose that a drug test for an illegal drug is such that it is 98% accurate in the case of a

    E-Print Network [OSTI]

    Gross, Louis J.

    Drug testing example for conditional probability Suppose that a drug test for an illegal drug is the probability that the tested individual uses this illegal drug? What is the probability of a false positive

  18. Winner of the 2014 $500,000 Lemelson-MIT Prize Dr. Sangeeta BhaCa Bha$a's combined clinical and engineering perspec$ve targets the development of miniaturized technologies to impact human

    E-Print Network [OSTI]

    Reif, Rafael

    $a and her trainees have launched ten companies with more than 70 products. She technologies to impact human health in areas ranging from drug toxicity, $ssue$on with probio$c vehicles to fine-tune dosing and delivery control. Methods to improve

  19. Skin: Major target organ of allergic reactions to small molecular weight compounds

    SciTech Connect (OSTI)

    Merk, Hans F. [Department of Dermatology and Allergology, Univ.-Hospital, RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen (Germany)], E-mail: hans.merk@post.rwth-aachen.de; Baron, Jens M.; Neis, Mark M.; Obrigkeit, Daniela Hoeller [Department of Dermatology and Allergology, Univ.-Hospital, RWTH Aachen, Pauwelsstr. 30, D-52074 Aachen (Germany); Karlberg, Ann-Therese [Dermatochemistry and Skin Allergy, Department of Chemistry, Goeteborg University, SE-412 96 Goeteborg (Sweden)

    2007-11-01T23:59:59.000Z

    Skin is a major target organ for allergic reactions to small molecular weight compounds. Drug allergic reactions may be life-threatening such as in the case of anaphylactic reactions or bullous drug reactions and occur in about 5% of all hospitalized patients. Allergic contact dermatitis has an enormous influence on the social life of the patient because it is the most frequent reason for occupational skin diseases and the treatment and prevention of this disease cost approximately Euro 3 billion per year in Germany. The different proposed pathophysiological pathways leading to a drug eruption are discussed in this paper. All major enzymes which are involved in the metabolism of xenobiotica were shown to be present in skin. Evidence supporting the role of metabolism in the development of drug allergy and allergic contact dermatitis is demonstrated in the example of sulphonamides and fragrances.

  20. The pipeline and future of drug development in schizophrenia

    E-Print Network [OSTI]

    Gray, J A; Roth, B L

    2007-01-01T23:59:59.000Z

    The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

  1. adverse drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  2. antiepileptic drug effects: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of alcohol and drugs. 6. Describe the personality traits of the alcoholic and drug addict. 7. Describe the treatment and rehabilitation of the alcoholic and drug addict. 8....

  3. Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

  4. Financing drug discovery for orphan diseases

    E-Print Network [OSTI]

    Fagnan, David Erik

    Recently proposed ‘megafund’ financing methods for funding translational medicine and drug development require billions of dollars in capital per megafund to de-risk the drug discovery process enough to issue long-term ...

  5. prescription drug program highlights retail pharmacy prescriptions

    E-Print Network [OSTI]

    Scharer, John E.

    prescription drug program highlights SHIP retail pharmacy prescriptions The informedRx retail interactions and duplicate therapies. Brand name and generic drugs are included in your pharmacy benefit, but you will save the most money by selecting generic drug options when available. On myinformedRx.com you

  6. Imaging in Drug Discovery and Development

    E-Print Network [OSTI]

    Zanibbi, Richard

    Imaging in Drug Discovery and Development Raymond Gibson Senior Investigator Merck, Sharp and Dohme aaarrrccchhhiiivvveeesss aaannnddd aaabbbssstttrrraaaccctttsss... #12;Abstract With the desire to develop novel drugs faster and more cost-effectively, drug companies are searching for clear strategies to manage the complex

  7. CMVO Drug Testing Program Request for Information

    E-Print Network [OSTI]

    Mazzotti, Frank

    CMVO Drug Testing Program Request for Information TO: RE: Name (First, M.I., Last) Social Security substances testing records. Please complete this form and return it to: University of Florida CMVO Drug or she has tested positive, or refused to test, on any pre-employment drug or alcohol test administered

  8. Investigational Drug/Device Accountability Policy Introduction

    E-Print Network [OSTI]

    Subramanian, Venkat

    2/11/08 Investigational Drug/Device Accountability Policy Introduction: Good clinical research investigational drug or device used in a research trial at Washington University. This is true whether the study-initiated trial using department funds. Our institutional responsibility requires that any investigational drug

  9. A. UNIVERSITY POLICIES ON ILLEGAL DRUGS AND

    E-Print Network [OSTI]

    Wang, Yuqing

    A. UNIVERSITY POLICIES ON ILLEGAL DRUGS AND ALCOHOL In conformance with the existing law or be under the influence of illegal drugs and/or alcohol as prohibited by state and federal law at University enforcement agencies responsible for enforcing laws related to the use of illegal drugs and alcohol. Students

  10. Possible Target Options Michael A. Green

    E-Print Network [OSTI]

    McDonald, Kirk

    Possible Target Options Michael A. Green WATER COOLED SOLID TARGETS For high energy drivers, a desirable target material should have a medium to high Z. For low energy drivers the targe should be made are obvious medium Z target materials. A less obvious candidate is a titanium or niobium-titanium alloy target

  11. Detect adverse drug reactions for drug Atorvastatin Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Atorvastatin Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Atorvastatin. Major side

  12. Drug Saf . Author manuscript Discourse on safe drug use: symbolic logics and ethical aspects

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Drug Saf . Author manuscript Page /1 5 Discourse on safe drug use: symbolic logics and ethical.fainzang@orange.fr > Abstract Drug safety is not a matter for healthcare professionals alone. As actors, patients are also concerned, at three different levels: 1) with regard to their behaviour and choices of drugs, with a view

  13. Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs

    E-Print Network [OSTI]

    Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs become empowered to share personal experiences regarding prescription drugs via Web page discussion from patient-provided drug reviews on health-related web sites. We focus on the statin class

  14. Detect adverse drug reactions for drug Simvastatin Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Simvastatin Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Simvastatin. Major side

  15. Detect adverse drug reactions for drug Alendronate Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Alendronate Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Alendronate. Major side

  16. 2012 Biennial Review: Drug-Free Schools and Communities Act and Drug-Free

    E-Print Network [OSTI]

    Tullos, Desiree

    2012 Biennial Review: Drug-Free Schools and Communities Act and Drug-Free Schools & Campuses from drugs and alcohol. The University supports programs for the prevention of abuse of alcohol. Biennial Review Process Oregon State University has a long history of engaging in drug and alcohol

  17. Detect adverse drug reactions for drug Pioglitazone Yihui Liu1,2

    E-Print Network [OSTI]

    Aickelin, Uwe

    Detect adverse drug reactions for drug Pioglitazone Yihui Liu1,2 1 Institute of Intelligent Department of Computer Science, University of Nottingham, UK Abstract--Adverse drug reaction (ADR) is widely feature matrix and feature selection. The experiments are carried out on the drug Pioglitazone. Major side

  18. Policy on Drug-Free Workplace Policy on Drug-Free Workplace

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Drug-Free Workplace 10/26/2014 Policy on Drug-Free Workplace I. Purpose and Scope responsible decision- making regarding the use of alcohol and other drugs. Northeastern strives to maintain drug use can create. Additionally, the University is committed to enforcing policies and laws realting

  19. Process management applications in biopharmaceutical drug production

    E-Print Network [OSTI]

    Smith, Stephen E

    2011-01-01T23:59:59.000Z

    Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products ...

  20. Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest

    SciTech Connect (OSTI)

    Kim, Ju-Hwa; Yoo, Hye-In; Kang, Han Sung; Ro, Jungsil [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)] [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of); Yoon, Sungpil, E-mail: yoons@ncc.re.kr [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)] [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)

    2012-02-03T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Sal sensitizes antimitotic drugs-treated cancer cells. Black-Right-Pointing-Pointer Sal sensitizes them by prevention of G2 arrest and reduced cyclin D1 levels. Black-Right-Pointing-Pointer Sal also sensitizes them by increasing DNA damage and reducing p21 level. Black-Right-Pointing-Pointer A low concentration of Sal effectively sensitized the cancer cells to antimitotic drugs. -- Abstract: Here, we investigated whether Sal could sensitize cancer cells to antimitotic drugs. We demonstrated that Sal sensitized paclitaxcel (PAC)-, docetaxcel (DOC)-, vinblastin (VIN)-, or colchicine (COL)-treated cancer cell lines, suggesting that Sal has the ability to sensitize the cells to any form of microtubule-targeting drugs. Sensitization to the antimitotic drugs could be achieved with very low concentrations of Sal, suggesting that there is a possibility to minimize Sal toxicity associated with human cancer patient treatments. Sensitization by Sal increased apoptosis, which was observed by C-PARP production. Sal sensitized the cancer cells to antimitotic drugs by preventing G2 arrest, suggesting that Sal contributes to the induction of mitotic catastrophe. Sal generally reduced cyclin D1 levels in PAC-, DOC-, and VIN-treated cells. In addition, Sal treatment increased pH2AX levels and reduced p21 levels in antimitotic drugs-treated cells. These observations suggest that the mechanisms underlying Sal sensitization to DNA-damaging compounds, radiation, and microtubule-targeting drugs are similar. Our data demonstrated that Sal sensitizes cancer cells to antimitotic drugs by increasing apoptosis through the prevention of G2 arrest via conserved Sal-sensitization mechanisms. These results may contribute to the development of Sal-based chemotherapy for cancer patients treated with antimitotic drugs.