National Library of Energy BETA

Sample records for targeted drug delivery

  1. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

    2012-08-28

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  2. Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery

    SciTech Connect (OSTI)

    Gu, Lina; He, Xiaomei; Wu, Zhenyu

    2014-11-15

    Highlights: Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite was synthesized by a simple, efficient and environmental friendly method. The prepared material had a large surface area, high pore volume, and good magnetic separability. DOX-loaded Fe{sub 3}O{sub 4}/hydroxyapatite composite exhibited surprising slow drug release behavior and pH-dependent behavior. - Abstract: In this contribution, we introduced a simple, efficient, and green method of preparing a mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite (HA) composite. The as-prepared material had a large surface area, high pore volume, and good magnetic separability, which made it suitable for targeted drug delivery systems. The chemotherapeutic agent doxorubicin (DOX) was used to investigate the drug release behavior of Fe{sub 3}O{sub 4}/HA composite. The drug release profiles displayed a little burst effect and pH-dependent behavior. The release rate of DOX at pH 5.8 was larger than that at pH 7.4, which could be attributed to DOX protonation in acid medium. In addition, the released DOX concentrations remained at 0.83 and 1.39 ?g/ml at pH 7.4 and 5.8, respectively, which indicated slow, steady, and safe release rates. Therefore, the as-prepared Fe{sub 3}O{sub 4}/hydroxyapatite composite could be an efficient platform for targeted anticancer drug delivery.

  3. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2011-04-28

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  4. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

    2002-01-01

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  5. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

    2002-01-01

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  6. Protein-Based Nanomedicine Platforms for Drug Delivery

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

    2009-08-03

    Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drugs efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein based drug delivery system.

  7. Automated High Throughput Drug Target Crystallography

    SciTech Connect (OSTI)

    Rupp, B

    2005-02-18

    The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

  8. Non-destructively shattered mesoporous silica for protein drug delivery

    Office of Scientific and Technical Information (OSTI)

    (Journal Article) | SciTech Connect Non-destructively shattered mesoporous silica for protein drug delivery Citation Details In-Document Search Title: Non-destructively shattered mesoporous silica for protein drug delivery Mesoporous silicas have been extensively used for entrapping small chemical molecules and biomacromolecules. We hypothesize that the loading density of biomacromlecules such as proteins in mesoporous silicas could be limited due to mesopore disorderness and depth because

  9. Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

    SciTech Connect (OSTI)

    Mhlanga, Nikiwe; Ray, Suprakas Sinha

    2015-05-22

    Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.

  10. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P. (1820 Mountain View Rd., Tiburon, CA 94920)

    1993-01-01

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  11. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  12. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu; Warren, Kaitlyn E; Naskar, Amit K

    2014-01-01

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  13. Alendronate functionalized mesoporous hydroxyapatite nanoparticles for drug delivery

    SciTech Connect (OSTI)

    Li, Dongdong; Zhu, Yuntao; Liang, Zhiqiang

    2013-06-01

    Highlights: ? The synthesized mesoporous hydroxyapatite has nanostructure and bioactivity. ? The materials have high surface area and amino group. ? The materials show higher drug loading and slower release rate than pure HAP. - Abstract: Mesoporous nanosized hydroxyapatite (HAP) functionalized by alendronate (ALN) was synthesized using cationic surfactant CTAB as template. The structural, morphological and textural properties were fully characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and N{sub 2} adsorption/desorption. Then the obtained materials were performed as drug delivery carriers using ibuprofen (IBU) as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). The materials showed relatively slower release rate compared with HAP due to the ionic interaction between -NH{sub 3}{sup +} on the matrix and -COO{sup ?}belongs to IBU. The system provides a new concept for improving the drug loading or slowing down the release rate.

  14. Artificial Cells for Advanced Drug Delivery - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biomass and Biofuels Biomass and Biofuels Find More Like This Return to Search Artificial Cells for Advanced Drug Delivery Colorado School of Mines Contact CSM About This Technology Technology Marketing SummaryThis invention takes advantage of the unique surface chemistry of a ZnO crystalline nanostructure to catalyze a variety of chemical reactions. DescriptionOne such reaction is the hydrogenation of carbon dioxide to methanol. Alcohols interacts both molecularly and dissociatively with the

  15. Molecule Nanoweaver Improves Drug Delivery and Treatment Efficacy - Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Innovation Portal Startup America Startup America Industrial Technologies Industrial Technologies Find More Like This Return to Search Molecule Nanoweaver Improves Drug Delivery and Treatment Efficacy Argonne National Laboratory Contact ANL About This Technology <p> Schematic of molecular assembly using molecule nanoweaver. The figure illustrates one of many (general) protocols or processes for creating a film tailored at the nanoscale, but overall having macroscale dimensions. The

  16. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II

  17. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural...

  18. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  19. DOE Technical Targets for Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Pipelines: Transmission Total capital investment (mile for an 8-in. diameter ... Trunk and Service Lines Total capital investment (mile for a 1-in. pipeline) ...

  20. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  1. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  2. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  3. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during

  4. Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

    DOE Patents [OSTI]

    Brinker, C Jeffrey; Ashley, Carlee Erin; Jiang, Xingmao; Liu, Juewen; Peabody, David S; Wharton, Walker Richard; Carnes, Eric; Chackerian, Bryce; Willman, Cheryl L

    2015-03-31

    Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

  5. Multiple-robot drug delivery strategy through coordinated teams of microswimmers

    SciTech Connect (OSTI)

    Kei Cheang, U; Kim, Min Jun; Lee, Kyoungwoo; Julius, Anak Agung

    2014-08-25

    Untethered robotic microswimmers are very promising to significantly improve various types of minimally invasive surgeries by offering high accuracy at extremely small scales. A prime example is drug delivery, for which a large number of microswimmers is required to deliver sufficient dosages to target sites. For this reason, the controllability of groups of microswimmers is essential. In this paper, we demonstrate simultaneous control of multiple geometrically similar but magnetically different microswimmers using a single global rotating magnetic field. By exploiting the differences in their magnetic properties, we triggered different swimming behaviors from the microswimmers by controlling the frequency and the strength of the global field, for example, one swim and the other does not while exposed to the same control input. Our results show that the balance between the applied magnetic torque and the hydrodynamic torque can be exploited for simultaneous control of two microswimmers to swim in opposite directions, with different velocities, and with similar velocities. This work will serve to establish important concepts for future developments of control systems to manipulate multiple magnetically actuated microswimmers and a step towards using swarms of microswimmers as viable workforces for complex operations.

  6. Alveolar targeting of aerosol pentamidine. Toward a rational delivery system

    SciTech Connect (OSTI)

    Simonds, A.K.; Newman, S.P.; Johnson, M.A.; Talaee, N.; Lee, C.A.; Clarke, S.W. )

    1990-04-01

    Nebulizer systems that deposit a high proportion of aerosolized pentamidine on large airways are likely to be associated with marked adverse side effects, which may lead to premature cessation of treatment. We have measured alveolar deposition and large airway-related side effects (e.g., cough, breathlessness, and effect on pulmonary function) after aerosolization of 150 mg pentamidine isethionate labeled with {sup 99m}Tc-Sn-colloid. Nine patients with AIDS were studied using three nebulizer systems producing different droplet size profiles: the Acorn System 22, Respirgard II, and Respirgard II with the inspiratory baffle removed. Alveolar deposition was greatest and side effects least with the nebulizer producing the smallest droplet size profile (Respirgard II), whereas large airway-related side effects were prominent and alveolar deposition lowest with the nebulizer producing the largest droplet size (Acorn System 22). Values for alveolar deposition and adverse airway effects were intermediate using the Respirgard with inspiratory baffle removed, thus indicating the importance of the baffle valve in determining droplet size. Addition of a similar baffle valve to the Acorn System 22 produced a marked improvement in droplet size profile. Selection of a nebulizer that produces an optimal droplet size range offers the advantage of enhancing alveolar targeting of aerosolized pentamidine while reducing large airway-related side effects.

  7. Use of supercritical fluid solution expansion processes for drug delivery, particle synthesis, and thin film deposition

    SciTech Connect (OSTI)

    Hybertson, B.M.

    1992-01-01

    Properties of the gases and aerosols resulting from the expansion of supercritical fluid solutions were studied. Film deposition, particle formation, and drug delivery processes using supercritical fluids were developed. Thin films of palladium, copper, aluminum, silver, and silicon dioxide were deposited by a method called supercritical fluid transport-chemical deposition (SFT-CD). In each case, a precursor compound was dissolved in a supercritical fluid and the solution was allowed to expand through a restrictor nozzle into a reaction chamber at subcritical pressure, resulting in the formation of aerosol particles of the precursor. A chemical reaction was induced to occur at the surface of a substrate, resulting in deposition of a thin film. Micron-sized particles of aluminum fluoride and copper oxide were synthesized by a method called supercritical fluid transport-chemical formation of particles (SFT-CFP). The process was similar to that in SFT-CD, but the chemical reactions were induced to occur in the gas phase instead of at a substrate surface, resulting in the formation of fine particles. A new method of pulmonary drug delivery called supercritical fluid drug delivery (SFDD) was conceived and demonstrated. In SFDD a drug compound is dissolved in a supercritical fluid, and the solution is allowed to expand through a restrictor nozzle. The resultant aerosol is directly inhaled by a human or animal subject and the fine drug particles are deposited in the lungs. Menthol, vanillin, camphor, cholesterol, Sudan III, and Oil Blue N were used as model drug compounds for SFDD. Delivery of [alpha]-tocopherol to rat lung tissue was demonstrated, with observed increases of 80-290% above background levels.

  8. Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection

    SciTech Connect (OSTI)

    Daniela Rodica Radu

    2005-12-19

    The central theme of this dissertation is represented by the versatility of mesoporous silica nanomaterials in various applications such as catalysis and bio-applications, with main focus on biological applications of Mesoporous Silica Nanospheres (MSN). The metamorphosis that we impose to these materials from catalysis to sensing and to drug and gene delivery is detailed in this dissertation. First, we developed a synthetic method that can fine tune the amount of chemically accessible organic functional groups on the pores surface of MSN by exploiting electrostatic and size matching between the cationic alkylammonium head group of the cetyltrimethylammonium bromide (CTAB) surfactant and various anionic organoalkoxysilane precursors at the micelle-water interface in a base-catalyzed condensation reaction of silicate. Aiming nature imitation, we demonstrated the catalytic abilities of the MSNs, We utilized an ethylenediamine functional group for chelating Cu{sup 2+} as a catalytic functional group anchored inside the mesopores. Thus, a polyalkynylene-based conducting polymer (molecular wire) was synthesized within the Cu-functionalized MSNs silica catalyst. For sensing applications, we have synthesized a poly(lactic acid) coated mesoporous silica nanosphere (PLA-MSN) material that serves as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. We exploited the mesoporosity of MSNs for encapsulating pharmaceutical drugs. We examined bio-friendly capping molecules such as polyamidoamine dendrimers of generations G2 to G4, to prevent the drug leaching. Next, the drug delivery system employed MSNs loaded with Doxorubicin, an anticancer drug. The results demonstrated that these nano-Trojan horses have ability to deliver Doxorubicin to cancer cells and induce their death. Finally, to demonstrate the potential of MSN as an universal cellular transmembrane nanovehicle, we anchored positively charged dendrimers on the surface of MSN and utilize them to complex cationic DNA. The p-EGFP-CI gene-coated MSN nanocomposite was able to transfect cancer cell lines, such as human HeLa and CHO cancer cell lines. The gene carrier ability of MSNs was further proved by transfecting primary cells and cotransfecting of two different genes in cancer cell lines. In sum, MSN are versatile partners in several types of applications.

  9. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer...

  10. Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles

    SciTech Connect (OSTI)

    Lammert, M. P.; Burton, J.; Sindler, P.; Duran, A.

    2014-10-01

    This research project compares laboratory-measured fuel economy of a medium-duty diesel powered hydraulic hybrid vehicle drivetrain to both a conventional diesel drivetrain and a conventional gasoline drivetrain in a typical commercial parcel delivery application. Vehicles in this study included a model year 2012 Freightliner P100H hybrid compared to a 2012 conventional gasoline P100 and a 2012 conventional diesel parcel delivery van of similar specifications. Drive cycle analysis of 484 days of hybrid parcel delivery van commercial operation from multiple vehicles was used to select three standard laboratory drive cycles as well as to create a custom representative cycle. These four cycles encompass and bracket the range of real world in-use data observed in Baltimore United Parcel Service operations. The NY Composite cycle, the City Suburban Heavy Vehicle Cycle cycle, and the California Air Resources Board Heavy Heavy-Duty Diesel Truck (HHDDT) cycle as well as a custom Baltimore parcel delivery cycle were tested at the National Renewable Energy Laboratory's Renewable Fuels and Lubricants Laboratory. Fuel consumption was measured and analyzed for all three vehicles. Vehicle laboratory results are compared on the basis of fuel economy. The hydraulic hybrid parcel delivery van demonstrated 19%-52% better fuel economy than the conventional diesel parcel delivery van and 30%-56% better fuel economy than the conventional gasoline parcel delivery van on cycles other than the highway-oriented HHDDT cycle.

  11. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo; Ji, Nan; Pan, Wen; Hong, Ru; Wang, Hao; Ji, Zhi-Liang

    2014-01-01

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: A novel computational framework was developed for mechanistic study of SADRs. Off-targets of drugs were identified in large scale and in a high-throughput manner. SADRs like cardiac disorders were systematically explored in molecular networks. A number of ADR-associated proteins were identified.

  12. Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion

    SciTech Connect (OSTI)

    Knobloch, M.; Portier, C.J.; Levionnois, O.L.; Theurillat, R.; Thormann, W.; Spadavecchia, C.; Mevissen, M. . E-mail: meike.mevissen@vpi.unibe.ch

    2006-11-01

    Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 {mu}g/ml S-ketamine over 120 min under isoflurane anesthesia was performed in Shetland ponies. A quantitative electromyographic assessment of the NWR was done before, during and after the TCI. Plasma levels of R-/S-ketamine and R-/S-norketamine were determined by enantioselective capillary electrophoresis. These data and two additional data sets from bolus studies were used to build a PBPk model for ketamine in ponies. The peak-to-peak amplitude and the duration of the NWR decreased significantly during TCI and returned slowly toward baseline values after the end of TCI. The PBPk model provides reliable prediction of plasma and tissue levels of R- and S-ketamine and R- and S-norketamine. Furthermore, biotransformation of ketamine takes place in the liver and in the lung via first-pass metabolism. Plasma concentrations of S-norketamine were higher compared to R-norketamine during TCI at all time points. Analysis of the data suggested identical biotransformation rates from the parent compounds to the principle metabolites (R- and S-norketamine) but different downstream metabolism to further metabolites. The PBPk model can provide predictions of R- and S-ketamine and norketamine concentrations in other clinical settings (e.g. horses)

  13. Measured Laboratory and In-Use Fuel Economy Observed over Targeted Drive Cycles for Comparable Hybrid and Conventional Package Delivery Vehicles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2-01-2049 Measured Laboratory and In-Use Fuel Economy Published Observed over Targeted Drive Cycles for 09/24/2012 Comparable Hybrid and Conventional Package Delivery Vehicles Michael P. Lammert, Kevin Walkowicz, Adam Duran and Petr Sindler National Renewable Energy Laboratory ABSTRACT This research project compares the in-use and laboratory- derived fuel economy of a medium-duty hybrid electric drivetrain with "engine off at idle" capability to a conventional drivetrain in a typical

  14. Targets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (11000th the width of a human hair). To aid in the extremely delicate manufacturing, NIF researchers developed a precision robotic target assembly machine. Workers regularly...

  15. Articulating feedstock delivery device

    DOE Patents [OSTI]

    Jordan, Kevin

    2013-11-05

    A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

  16. Target

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    kinematics Coulex Target e.g. C Stopper e.g. Cu Beam X X * C Si-Det. Yale Plunger 120 Te at 300 MeV Plunger foils Si-Detector Compton-suppressed Clover detectors (8) 50%...

  17. Hydrothermal synthesis and afterglow luminescence properties of hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres for potential application in drug delivery

    SciTech Connect (OSTI)

    Feng, Pengfei; Zhang, Jiachi Qin, Qingsong; Hu, Rui; Wang, Yuhua

    2014-02-01

    Highlights: We designed a novel afterglow labeling material SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} for the first time. Hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres with afterglow were prepared by hydrothermal method. Hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} is a potential afterglow labeling medium for drug delivery. - Abstract: A novel afterglow labeling material SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} with hollow sphere shape and intense afterglow luminescence is prepared by hydrothermal method at 180 C for the first time. The morphology and the sphere growth process of this material are investigated by scanning electron microscopy in detail. The afterglow measurement shows that this hydrothermal obtained material exhibits obvious red afterglow luminescence (550700 nm) of Sm{sup 3+} which can last for 542 s (0.32 mcd/m{sup 2}). The depth of traps in this hydrothermal obtained material is calculated to be as shallow as 0.58 eV. The results demonstrate that although it is necessary to further improve the afterglow performance of the hydrothermal derived hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres, it still can be regarded as a potential afterglow labeling medium for drug delivery.

  18. Measured Laboratory and In-Use Fuel Economy Observed over Targeted Drive Cycles for Comparable Hybrid and Conventional Package Delivery Vehicles

    SciTech Connect (OSTI)

    Lammert, M. P.; Walkowicz, K.; Duran, A.; Sindler, P.

    2012-10-01

    In-use and laboratory-derived fuel economies were analyzed for a medium-duty hybrid electric drivetrain with 'engine off at idle' capability and a conventional drivetrain in a typical commercial package delivery application. Vehicles studied included eleven 2010 Freightliner P100H hybrids in service at a United Parcel Service facility in Minneapolis during the first half of 2010. The hybrids were evaluated for 18 months against eleven 2010 Freightliner P100D diesels at the same facility. Both vehicle groups use the same 2009 Cummins ISB 200-HP engine. In-use fuel economy was evaluated using UPS's fueling and mileage records, periodic ECM image downloads, and J1939 CAN bus recordings during the periods of duty cycle study. Analysis of the in-use fuel economy showed 13%-29% hybrid advantage depending on measurement method, and a delivery route assignment analysis showed 13%-26% hybrid advantage on the less kinetically intense original diesel route assignments and 20%-33% hybrid advantage on the more kinetically intense original hybrid route assignments. Three standardized laboratory drive cycles were selected that encompassed the range of real-world in-use data. The hybrid vehicle demonstrated improvements in ton-mi./gal fuel economy of 39%, 45%, and 21% on the NYC Comp, HTUF Class 4, and CARB HHDDT test cycles, respectively.

  19. Self-assembled pentablock copolymers for selective and sustained gene delivery

    SciTech Connect (OSTI)

    Zhang, Bingqi

    2011-05-15

    The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

  20. Non-destructively shattered mesoporous silica for protein drug...

    Office of Scientific and Technical Information (OSTI)

    Non-destructively shattered mesoporous silica for protein drug delivery Citation Details In-Document Search Title: Non-destructively shattered mesoporous silica for protein drug ...

  1. Prescription Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue...

  2. Hydrogen delivery technology roadmap

    SciTech Connect (OSTI)

    None, None

    2005-11-15

    Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

  3. Evaluation of Retrofit Delivery Packages

    SciTech Connect (OSTI)

    Berman, M.; Smith, P.; Porse, E.

    2013-07-01

    Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

  4. Target Chamber

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Diagnostic ports are about one-half meter in diameter and are generally concentrated around the "waist" of the target chamber Target handling systems precisely position the target ...

  5. Delivery Analysis | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Systems Analysis » Analysis Methodologies » Delivery Analysis Delivery Analysis Delivery Analysis identifies the most economic options for delivering hydrogen, and provides a foundation for additional research on alternative storage and transportation options. Additionally, delivery analysis provides crucial information to technology feasibility analysis, in determining the optimal production capacities and locations. Delivery analyses will be conducted to determine the most promising

  6. National Electricity Delivery Division

    Office of Environmental Management (EM)

    (DOE) Office of Electricity Delivery and Energy Reliability (OE) National Electricity Delivery Division Julie Ann Smith, PhD September 24, 2015 The Federal Indian Trust Responsibility is a legal obligation under which the United States has charged itself with moral obligations of the highest responsibility and trust toward American Indian tribes. (Seminole Nation v. United States, 1942; Cherokee Nation v. Georgia, 1831). "When the trust responsibility is acknowledged and upheld by the

  7. Vulnerability Analysis of Energy Delivery Control Systems - 2011 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Systems - 2011 Vulnerability Analysis of Energy Delivery Control Systems - 2011 Cybersecurity for energy delivery systems has emerged as one of the Nation's most serious grid modernization and infrastructure protection issues. Cyber adversaries are becoming increasingly targeted, sophisticated, and better financed. The energy sector must research, develop and deploy new cybersecurity capabilities faster than the adversary can launch new attack tools and techniques. The

  8. Sputter target

    DOE Patents [OSTI]

    Gates, Willard G.; Hale, Gerald J.

    1980-01-01

    The disclosure relates to an improved sputter target for use in the deposition of hard coatings. An exemplary target is given wherein titanium diboride is brazed to a tantalum backing plate using a gold-palladium-nickel braze alloy.

  9. VIA EMAIL DELIVERY

    Broader source: Energy.gov (indexed) [DOE]

    VIA EMAIL DELIVERY March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585 Lamont.Jackson@hq.doe.gov Re: Request for Information, OE Docket No. RRTT-IR-001, Rapid Response Team for Transmission Dear Mr. Jackson: TransWest Express LLC (TransWest) appreciates the opportunity to respond to the Department of Energy's questions related to permitting transmission lines, as outlined in the February

  10. Fluid delivery control system

    DOE Patents [OSTI]

    Hoff, Brian D.; Johnson, Kris William; Algrain, Marcelo C.; Akasam, Sivaprasad

    2006-06-06

    A method of controlling the delivery of fluid to an engine includes receiving a fuel flow rate signal. An electric pump is arranged to deliver fluid to the engine. The speed of the electric pump is controlled based on the fuel flow rate signal.

  11. Target isolation system, high power laser and laser peening method and system using same

    DOE Patents [OSTI]

    Dane, C. Brent (Livermore, CA); Hackel, Lloyd A. (Livermore, CA); Harris, Fritz (Rocklin, CA)

    2007-11-06

    A system for applying a laser beam to work pieces, includes a laser system producing a high power output beam. Target delivery optics are arranged to deliver the output beam to a target work piece. A relay telescope having a telescope focal point is placed in the beam path between the laser system and the target delivery optics. The relay telescope relays an image between an image location near the output of the laser system and an image location near the target delivery optics. A baffle is placed at the telescope focal point between the target delivery optics and the laser system to block reflections from the target in the target delivery optics from returning to the laser system and causing damage.

  12. Nano compartments may aid drug delivery, catalyst design > Archived...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    researcher Teeraporn Suteewong and graduate student Hiroaki Sai, have tweaked familiar "sol-gel" chemistry used to self-assemble porous silica particles, making the assembly shift...

  13. Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Hydrogen Delivery A viable hydrogen infrastructure requires that hydrogen be able to be delivered from where it's produced to the point of end-use, such as a dispenser at a refueling station or stationary power site. Infrastructure includes the pipelines, trucks, storage facilities, compressors, and dispensers involved in the process of delivering fuel. Delivery technology for hydrogen infrastructure is currently available commercially, and several U.S. companies deliver bulk hydrogen

  14. Secondary fuel delivery system

    DOE Patents [OSTI]

    Parker, David M. (Oviedo, FL); Cai, Weidong (Oviedo, FL); Garan, Daniel W. (Orlando, FL); Harris, Arthur J. (Orlando, FL)

    2010-02-23

    A secondary fuel delivery system for delivering a secondary stream of fuel and/or diluent to a secondary combustion zone located in the transition piece of a combustion engine, downstream of the engine primary combustion region is disclosed. The system includes a manifold formed integral to, and surrounding a portion of, the transition piece, a manifold inlet port, and a collection of injection nozzles. A flowsleeve augments fuel/diluent flow velocity and improves the system cooling effectiveness. Passive cooling elements, including effusion cooling holes located within the transition boundary and thermal-stress-dissipating gaps that resist thermal stress accumulation, provide supplemental heat dissipation in key areas. The system delivers a secondary fuel/diluent mixture to a secondary combustion zone located along the length of the transition piece, while reducing the impact of elevated vibration levels found within the transition piece and avoiding the heat dissipation difficulties often associated with traditional vibration reduction methods.

  15. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein...

  16. Hydrogen Distribution and Delivery Infrastructure

    SciTech Connect (OSTI)

    2008-11-01

    This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challenges to delivering hydrogen for use as a widespread energy carrier, and the research goals for hydrogen delivery.

  17. Hydrogen Delivery Technical Team Roadmap

    SciTech Connect (OSTI)

    2013-06-01

    The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen.

  18. Target assembly

    DOE Patents [OSTI]

    Lewis, Richard A. (Falls Church, VA)

    1980-01-01

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  19. National Electric Delivery Technologies Roadmap: Transforming...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Technologies Roadmap: Transforming the Grid to Revolutionize Electric Power in North America National Electric Delivery Technologies Roadmap: Transforming the Grid to ...

  20. Final Report - Hydrogen Delivery Infrastructure Options Analysis...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Report - Hydrogen Delivery Infrastructure Options Analysis Final Report - Hydrogen Delivery Infrastructure Options Analysis This report, by the Nexant team, documents an in-depth...

  1. Hydrogen Delivery Infrastructure Analysis, Options and Trade...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review ... DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting ...

  2. Hydrogen Delivery Analysis Models | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Models Hydrogen Delivery Analysis Models DOE H2A Delivery Models: Components Model ...interstate markets and demand levels, market penetration) PDF icon ...

  3. Accelerator target

    DOE Patents [OSTI]

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  4. Accelerator target

    DOE Patents [OSTI]

    Schlyer, David J.; Ferrieri, Richard A.; Koehler, Conrad

    1999-01-01

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  5. Variable delivery, fixed displacement pump

    DOE Patents [OSTI]

    Sommars, Mark F. (Sparland, IL)

    2001-01-01

    A variable delivery, fixed displacement pump comprises a plurality of pistons reciprocated within corresponding cylinders in a cylinder block. The pistons are reciprocated by rotation of a fixed angle swash plate connected to the pistons. The pistons and cylinders cooperate to define a plurality of fluid compression chambers each have a delivery outlet. A vent port is provided from each fluid compression chamber to vent fluid therefrom during at least a portion of the reciprocal stroke of the piston. Each piston and cylinder combination cooperates to close the associated vent port during another portion of the reciprocal stroke so that fluid is then pumped through the associated delivery outlet. The delivery rate of the pump is varied by adjusting the axial position of the swash plate relative to the cylinder block, which varies the duration of the piston stroke during which the vent port is closed.

  6. Hydrogen Distribution and Delivery Infrastructure

    Fuel Cell Technologies Publication and Product Library (EERE)

    This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

  7. Hydrogen Delivery Infrastructure Options Analysis

    Fuel Cell Technologies Publication and Product Library (EERE)

    This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

  8. Electricity Delivery and Energy Reliability

    Broader source: Energy.gov (indexed) [DOE]

    Delivery and Energy Reliability The Office of Electricity Delivery and Energy Reliability (OE) drives electric grid modernization and resiliency in the energy infrastructure while working to enable innovation across the energy sector, empowering American consumers, and securing our energy future. The OE mission and the leadership role OE plays in the energy industry directly support the President's effort to accelerate the transformation of America's energy system through research and

  9. Radiation delivery system and method

    DOE Patents [OSTI]

    Sorensen, Scott A.; Robison, Thomas W.; Taylor, Craig M. V.

    2002-01-01

    A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

  10. ARM - Data Gathering and Delivery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Gathering and Delivery Data Gathering and Delivery Collecting the Data The ARM Climate Research Facility instruments automatically collect data on surface and atmospheric properties, and the information is sent to the site data systems. In addition to the instruments, ARM data is also gathered through aircraft, forecast models, satellites, field campaigns, and value-added processing. Aircraft Scientists will often use aircraft to gather airborne data during field campaigns at an ARM Climate

  11. Hydrogen Delivery Technology Roadmap, November 2005

    Fuel Cell Technologies Publication and Product Library (EERE)

    Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

  12. Hydrogen Delivery Roadmap | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Roadmap Hydrogen Delivery Roadmap The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen. PDF icon hdtt_roadmap_june2013.pdf More Documents & Publications US DRIVE Hydrogen Delivery Technical Team Roadmap Delivery Tech

  13. Energy Delivery Systems Cybersecurity | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cybersecurity » Energy Delivery Systems Cybersecurity Energy Delivery Systems Cybersecurity About the Cybersecurity for Energy Delivery Systems Program A key mission of the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is to enhance the reliability and resilience of the nation's energy infrastructure. Cybersecurity of energy delivery systems is critical for protecting the energy infrastructure and the integral function that it serves in our lives. OE

  14. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  15. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  16. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  17. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell growth. Protein kinases have in general been the target of many cancer drug designs, since

  18. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Target 2 Target 2 is housed in...

  19. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Target 2 Target 2 is housed in...

  20. Agenda for the Hydrogen Delivery and Onboard Storage Analysis...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage...

  1. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the...

  2. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  3. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  4. Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Education * Increase executive understanding of energy delivery system cybersecurity ... threat actor models (expertise motivationattack vector) * Develop deceptive ...

  5. Energy Delivery Systems Cybersecurity | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    About the Cybersecurity for Energy Delivery Systems Program A key mission of the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is to enhance the reliability and resilience of the nation's energy infrastructure. Cybersecurity of energy delivery systems is critical for protecting the energy infrastructure and the integral function that it serves in our lives. OE designed the Cybersecurity for Energy Delivery Systems (CEDS) program to assist the energy

  6. Delivery Tech Team | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Tech Team Delivery Tech Team Presentation by 02-Parks to DOE Hydrogen Pipeline R&D Project Review Meeting held January 5-6, 2005 at Oak Ridge National Laboratory in Oak Ridge, Tennessee. PDF icon 02_parks_freedomcar.pdf More Documents & Publications Overview of FreedomCAR & Fuels Partnership/DOE Delivery Program Hydrogen Delivery Options and Issues President's Hydrogen Fuel Initiative

  7. Hydrogen Delivery Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Delivery Related Links Hydrogen Delivery Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded hydrogen delivery activities, research plans and roadmaps, models and tools, and additional related links. DOE-Funded Hydrogen Delivery Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters and

  8. Streamline Service Delivery via Customer Communication and Contractor...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Streamline Service Delivery via Customer Communication and Contractor Coordination Streamline Service Delivery via Customer Communication and Contractor Coordination Better ...

  9. Hydrogen Distribution and Delivery Fact Sheet | Department of Energy

    Energy Savers [EERE]

    Distribution and Delivery Fact Sheet Hydrogen Distribution and Delivery Fact Sheet Fact sheet produced by the Fuel Cell Technologies Office describing hydrogen distribution and delivery infrastructure. PDF icon Hydrogen Distribution and Delivery More Documents & Publications Hydrogen Delivery Roadmap US DRIVE Hydrogen Delivery Technical Team Roadmap Hydrogen Transmission and Distribution Workshop

  10. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. About Target 2 - Lead Slowing...

  11. Multirate delivery of multiple therapeutic agents from metal-organic frameworks

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    McKinlay, Alistair C.; Allan, Phoebe K.; Renouf, Catherine L.; Duncan, Morven J.; Wheatley, Paul S.; Warrender, Stewart J.; Dawson, Daniel; Ashbrook, Sharon E.; Gil, Barbara; Marszalek, Bartosz; et al

    2014-12-01

    The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

  12. Multirate delivery of multiple therapeutic agents from metal-organic frameworks

    SciTech Connect (OSTI)

    McKinlay, Alistair C.; Allan, Phoebe K.; Renouf, Catherine L.; Duncan, Morven J.; Wheatley, Paul S.; Warrender, Stewart J.; Dawson, Daniel; Ashbrook, Sharon E.; Gil, Barbara; Marszalek, Bartosz; Dren, Tina; Williams, Jennifer J.; Charrier, Cedric; Mercer, Derry K.; Teat, Simon J.; Morris, Russell E.

    2014-12-01

    The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agentsa biologically active gas, an antibiotic drug molecule, and an active metal ionsimultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

  13. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    can give rise to chromosome breaks, which in turn can lead to genome instabilities and cell death. The topo II enzyme performs this unraveling for DNA in the cell. Antibacterial...

  14. Exploring the Limits of Methane Storage and Delivery in Nanoporous Materials

    SciTech Connect (OSTI)

    Gomez-Gualdron, DA; Wilmer, CE; Farha, OK; Hupp, JT; Snurr, RQ

    2014-04-03

    The physical limits for methane storage and delivery in nanoporous materials were investigated, with a focus on whether it is possible to reach a methane deliverable capacity of 315 cm(3)(STP)/cm(3) in line with the adsorption target established by the ARPA-E agency. Our efforts focused on how both geometric and chemical properties, such as void fraction (V-f), volumetric surface area (S-v), and heat of adsorption (Q(st)), impact methane deliverable capacity, i.e., the amount of methane adsorbed at some storage pressure minus the amount adsorbed at the delivery pressure. With the aid of grand canonical Monte Carlo (GCMC) simulations, we studied methane adsorption and delivery properties in a population of 122 835 hypothetical pcu metal organic frameworks (MOFs) and 39 idealized carbon-based porous materials. From the simulation results, we developed an analytical equation that helped us delimit the necessary material properties to reach specific methane deliverable capacity targets. The maximum deliverable capacity between 65 and 5.8 bar among the hypothetical MOFs was 206 cm(3)(STP)/cm(3) at 298 K. We found that artificially increasing the methane MOF interaction strength by increasing the Lennard-Jones e parameters of the MOF atoms by 2- and 4-fold only improved the maximum deliverable capacity up to 223 and 228 cm(3)(STP)/cm(3), respectively. However, the effect on the amount stored at 65 bar was more significant, which suggested another strategy; raising the temperature of the system by 100 K can recover 70% of the methane stranded at the delivery pressure. By increasing the delivery temperature to 398 K, the ARPA-E target was reached by a few hypothetical MOFs with quadrupled e values. This work shows the difficulty in reaching the ARPA-E target but also suggests that a strategy that combines a material with a large volumetric density of sites that interact strongly with methane and raising the delivery temperature can greatly improve the performance of nanoporous materials for methane storage and delivery. The optimal heat of adsorption in an isothermal storage and delivery scenario is approximately 10.5-14.5 kJ/mol, whereas in the nonisothermal storage and delivery scenario the optimal heats of adsorption fell within a range of 11.8-19.8 kEmol.

  15. Fiber coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO)

    2008-08-12

    A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

  16. Integrated Waste Feed Delivery Plan - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Documents Integrated Waste Feed Delivery Plan Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Integrated Waste Feed Delivery Plan Email Email Page | Print

  17. LNG - Engine Delivery - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vehicles and Fuels Vehicles and Fuels Find More Like This Return to Search LNG - Engine Delivery Idaho National Laboratory Contact INL About This Technology Technology Marketing Summary This is a method of improved delivery of liquid natural gas (LNG) within an engine delivery system. The LNG is first pumped into the insulated holding tank from a fueling station. As a tank is refueled, any remaining natural gas vapors are condensed and returned to the liquid state. This allows the tank to fill

  18. Liquid Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Delivery » Liquid Hydrogen Delivery Liquid Hydrogen Delivery Hydrogen is most commonly transported and delivered as a liquid when high-volume transport is needed in the absence of pipelines. To liquefy hydrogen it must be cooled to cryogenic temperatures through a liquefaction process. Trucks transporting liquid hydrogen are referred to as liquid tankers. Liquefaction Gaseous hydrogen is liquefied by cooling it to below -253°C (-423°F). Once hydrogen is liquefied it can be stored at

  19. Delivery and Receipt | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery and Receipt Delivery and Receipt Delivery and Receipt of Personal Property Acquired by Purchase Card at Headquarters Receiving Items Purchased with the Purchase Card that are Shipped or Delivered by the Vendor All personal property acquired by using the purchase card should generally be delivered to and processed by the receiving office (loading dock). This will ensure inventory control identification, as appropriate and recording in the personal property management records. The

  20. A Case Study in Proton Pencil-Beam Scanning Delivery

    SciTech Connect (OSTI)

    Kooy, Hanne M.; Clasie, Benjamin M.; Lu, H.-M.; Madden, Thomas M.; Bentefour, Hassan; Depauw, Nicolas M.S.; Adams, Judy A.; Trofimov, Alexei V.; Demaret, Denis; Delaney, Thomas F.; Flanz, Jacob B.

    2010-02-01

    Purpose: We completed an implementation of pencil-beam scanning (PBS), a technology whereby a focused beam of protons, of variable intensity and energy, is scanned over a plane perpendicular to the beam axis and in depth. The aim of radiotherapy is to improve the target to healthy tissue dose differential. We illustrate how PBS achieves this aim in a patient with a bulky tumor. Methods and Materials: Our first deployment of PBS uses 'broad' pencil-beams ranging from 20 to 35 mm (full-width-half-maximum) over the range interval from 32 to 7 g/cm{sup 2}. Such beam-brushes offer a unique opportunity for treating bulky tumors. We present a case study of a large (4,295 cc clinical target volume) retroperitoneal sarcoma treated to 50.4 Gy relative biological effectiveness (RBE) (presurgery) using a course of photons and protons to the clinical target volume and a course of protons to the gross target volume. Results: We describe our system and present the dosimetry for all courses and provide an interdosimetric comparison. Discussion: The use of PBS for bulky targets reduces the complexity of treatment planning and delivery compared with collimated proton fields. In addition, PBS obviates, especially for cases as presented here, the significant cost incurred in the construction of field-specific hardware. PBS offers improved dose distributions, reduced treatment time, and reduced cost of treatment.

  1. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Takeda Advances Diabetes Drug Development at the ALS Print Tuesday, 19 May 2015 12:25 Type 2 diabetes mellitus (T2DM), characterized by abnormally high blood glucose levels, affects hundreds of millions of people worldwide. In the pursuit to better treat this disease, the human receptor protein GPR40 has been identified by pharmaceutical company Takeda as a potential new drug target. To this end, TAK-875 (fasiglifam), a partial agonist of

  2. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein kinase Blc-Abl, while not targeting homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in regulating cell

  3. Aggressive Underwriting and Smart Product Delivery | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Aggressive Underwriting and Smart Product Delivery Presents AFC First's expert knowledge on lending products, financing, and contractor-friendly loan processes. PDF icon...

  4. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the ALS. See Shipping and Receiving for information on any non-gas deliveries. Contacts: Gas purchase or delivery: ALS Receiving, 510-486-4494 Gas use and storage: Experiment Coordination, 510-486-7222, This e-mail address is being protected from spambots. You need JavaScript enabled to view it Gas Storage: Berkeley Lab

  5. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the ALS. See Shipping and Receiving for information on any non-gas deliveries. Contacts: Gas purchase or delivery: ALS Receiving, 510-486-4494 Gas use and storage: Experiment Coordination, 510-486-7222, This e-mail address is being protected from spambots. You need JavaScript enabled to view it Gas Storage: Berkeley Lab

  6. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the ALS. See Shipping and Receiving for information on any non-gas deliveries. Contacts: Gas purchase or delivery: ALS Receiving, 510-486-4494 Gas use and storage: Experiment Coordination, 510-486-7222, This e-mail address is being protected from spambots. You need JavaScript enabled to view it Gas Storage: Berkeley Lab

  7. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the ALS. See Shipping and Receiving for information on any non-gas deliveries. Contacts: Gas purchase or delivery: ALS Receiving, 510-486-4494 Gas use and storage: Experiment Coordination, 510-486-7222, This e-mail address is being protected from spambots. You need JavaScript enabled to view it Gas Storage: Berkeley Lab

  8. Purchase, Delivery, and Storage of Gases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the ALS. See Shipping and Receiving for information on any non-gas deliveries. Contacts: Gas purchase or delivery: ALS Receiving, 510-486-4494 Gas use and storage: Experiment Coordination, 510-486-7222, This e-mail address is being protected from spambots. You need JavaScript enabled to view it Gas Storage: Berkeley Lab

  9. Energy Delivery Systems Cybersecurity | Department of Energy

    Energy Savers [EERE]

    the country. CEDS program activities fall under five project areas, guided by the Roadmap to Achieve Energy Delivery Systems Cybersecurity. They are: Build a Culture of...

  10. 2014 Revenue for Delivery Service Providers

    U.S. Energy Information Administration (EIA) Indexed Site

    Revenue for Delivery Service Providers" "(Data from form EIA-861 schedule 4C)" ,,,"Revenue (Thousands Dollars)" "Entity","State","Ownership","Residential","Commercial","Industrial"...

  11. Final Report- Hydrogen Delivery Infrastructure Options Analysis

    Broader source: Energy.gov [DOE]

    This report provides in-depth analysis of various hydrogen delivery options to determine the most cost effective infrastructure and R&D efforts for the long term.

  12. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, Roy J.

    1986-01-01

    A polarized internal target apparatus with a polarized gas target of improved polarization and density achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms.

  13. Polarized internal target apparatus

    DOE Patents [OSTI]

    Holt, R.J.

    1984-10-10

    A polarized internal target apparatus with a polarized gas target of improved polarization and density (achieved by mixing target gas atoms with a small amount of alkali metal gas atoms, and passing a high intensity polarized light source into the mixture to cause the alkali metal gas atoms to become polarized which interact in spin exchange collisions with target gas atoms yielding polarized target gas atoms) is described.

  14. Electrically charged targets

    DOE Patents [OSTI]

    Goodman, Ronald K. (Livermore, CA); Hunt, Angus L. (Alamo, CA)

    1984-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  15. Target tracking using DMLC for volumetric modulated arc therapy: A simulation study

    SciTech Connect (OSTI)

    Sun Baozhou; Rangaraj, Dharanipathy; Papiez, Lech; Oddiraju, Swetha; Yang Deshan; Li, H. Harold

    2010-12-15

    Purpose: Target tracking using dynamic multileaf collimator (DMLC) is a promising approach for intrafraction motion management in radiation therapy. The purpose of this work is to develop a DMLC tracking algorithm capable of delivering volumetric-modulated arc therapy (VMAT) to the targets that experience two-dimensional (2D) rigid motion in the beam's eye view. Methods: The problem of VMAT delivery to moving targets is formulated as a control problem with constraints. The relationships between gantry speed, gantry acceleration, MLC leaf-velocity, dose rate, and target motion are derived. An iterative search algorithm is developed to find numerical solutions for efficient delivery of a specific VMAT plan to the moving target using 2D DMLC tracking. The delivery of five VMAT lung plans is simulated. The planned and delivered fluence maps in the target-reference frame are calculated and compared. Results: The simulation demonstrates that the 2D tracking algorithm is capable of delivering the VMAT plan to a moving target fast and accurately without violating the machine constraints and the integrity of the treatment plan. The average delivery time is only 29 s longer than that of no-tracking delivery, 101 versus 72 s, respectively. The fluence maps are normalized to 200 MU and the average root-mean-square error between the desired and the delivered fluence is 2.1 MU, compared to 14.8 MU for no-tracking and 3.6 MU for one-dimensional tracking. Conclusions: A locally optimal MLC tracking algorithm for VMAT delivery is proposed, aiming at shortest delivery time while maintaining treatment plan invariant. The inconsequential increase of treatment time due to DMLC tracking is clinically desirable, which makes VMAT with DMLC tracking attractive in treating moving tumors.

  16. Hydrogen Delivery Infrastructure Option Analysis | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Option Analysis Hydrogen Delivery Infrastructure Option Analysis Presentation on hydrogen delivery infrastructure option analysis prepared for DOE. PDF icon wkshp_storage_chen.pdf More Documents & Publications Hydrogen Delivery Options and Issues H2A Delivery Models and Results Potential Carriers and Approaches for Hydrogen Delivery

  17. Magnetically attached sputter targets

    DOE Patents [OSTI]

    Makowiecki, D.M.; McKernan, M.A.

    1994-02-15

    An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

  18. Fiber laser coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

    2008-03-04

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  19. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - Scientific Applications Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Lead...

  20. Flight Path Target 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - Publications Target 2 provides experimenters direct access to the 800 MeV proton beam as well as several flight paths. Target 2 is located in MPF-7 at LANSCE.. Jonathan W....

  1. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  2. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Documents & Publications Hydrogen Delivery Analysis Models Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Joint Meeting on Hydrogen...

  3. H2A Delivery: Forecourt Compression & Storage Optimization (Part...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery: Forecourt Compression & Storage Optimization (Part II) H2A Delivery: Forecourt Compression & Storage Optimization (Part II) Presentation by Matthew Hooks of TIAX at the...

  4. Secretary of Energy Announces New Office of Electricity Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    New Office of Electricity Delivery & Energy Reliability Secretary of Energy Announces New Office of Electricity Delivery & Energy Reliability June 9, 2005 - 1:45pm Addthis...

  5. Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Vehicles Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery Vehicles The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a ...

  6. Secretary Steven Chu's Remarks as Prepared for Delivery to the...

    Office of Environmental Management (EM)

    Secretary Steven Chu's Remarks as Prepared for Delivery to the DOE Tribal Summit Secretary Steven Chu's Remarks as Prepared for Delivery to the DOE Tribal Summit Secretary Steven...

  7. Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results This presentation by...

  8. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Attendees List Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Attendees List Attendee list from the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May...

  9. FY 2014 Budget Request for the Office of Electricity Delivery...

    Office of Environmental Management (EM)

    4 Budget Request for the Office of Electricity Delivery and Energy Reliability FY 2014 Budget Request for the Office of Electricity Delivery and Energy Reliability Table showing...

  10. 2013 Annual Planning Summary for the Office of Electricity Delivery...

    Energy Savers [EERE]

    Electricity Delivery and Energy Reliability 2013 Annual Planning Summary for the Office of Electricity Delivery and Energy Reliability The ongoing and projected Environmental...

  11. West Virginia Natural Gas Deliveries to Electric Power Consumers...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) West Virginia Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul...

  12. Wisconsin Natural Gas Deliveries to Electric Power Consumers...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) Wisconsin Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug...

  13. Kentucky Natural Gas Deliveries to Electric Power Consumers ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) Kentucky Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug...

  14. Minnesota Natural Gas Deliveries to Electric Power Consumers...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) Minnesota Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug...

  15. Part IV: Section F - Deliveries or Performance

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    F DELIVERIES OR PERFORMANCE DE-AC36-08GO28308 Modification M933 Section F - Page ii PART I SECTION F DELIVERIES OR PERFORMANCE TABLE OF CONTENT F.1 Term of Contract 1 F.2 Principal Place of Performance 1 F.3 FAR 52.242-15 Stop-Work Order (Aug 1989) (Alternate 1) (Apr 1984) 1 DE-AC36-08GO28308 Modification M933 Section F - Page 1 of 2 PART I SECTION F DELIVERIES OR PERFORMANCE F.1 Term of Contract (a) This contract shall be effective as specified in Block No. 28, Award Date, of SF 33, and shall

  16. Bar coded retroreflective target

    DOE Patents [OSTI]

    Vann, Charles S. (Fremont, CA)

    2000-01-01

    This small, inexpensive, non-contact laser sensor can detect the location of a retroreflective target in a relatively large volume and up to six degrees of position. The tracker's laser beam is formed into a plane of light which is swept across the space of interest. When the beam illuminates the retroreflector, some of the light returns to the tracker. The intensity, angle, and time of the return beam is measured to calculate the three dimensional location of the target. With three retroreflectors on the target, the locations of three points on the target are measured, enabling the calculation of all six degrees of target position. Until now, devices for three-dimensional tracking of objects in a large volume have been heavy, large, and very expensive. Because of the simplicity and unique characteristics of this tracker, it is capable of three-dimensional tracking of one to several objects in a large volume, yet it is compact, light-weight, and relatively inexpensive. Alternatively, a tracker produces a diverging laser beam which is directed towards a fixed position, and senses when a retroreflective target enters the fixed field of view. An optically bar coded target can be read by the tracker to provide information about the target. The target can be formed of a ball lens with a bar code on one end. As the target moves through the field, the ball lens causes the laser beam to scan across the bar code.

  17. Categorical Exclusion Determinations: Office of Electricity Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Gallium Nitride Electronics for Grid Applications CX(s) Applied: A1, A2, A9, A11, B3.6 Date: 08172011 Location(s): Cambridge, Massachusetts Office(s): Electricity Delivery and ...

  18. Hydrogen Delivery Scenario Analysis Model (HDSAM)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Scenario Analysis Model (HDSAM) (Argonne National Laboratory) Objectives Provide platform for comparing the cost of alternative hydrogen delivery and refueling options. Identify cost drivers of current hydrogen delivery and refueling technologies for various market penetrations of fuel cell electric vehicles (FCEVs). Key Attributes & Strengths The tool is highly flexible, allowing end users the ability to change many detailed input assumptions and to perform sensitivity analyses. HDSAM

  19. Office of Electricity Delivery and Energy Reliability

    Energy Savers [EERE]

    Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Department of Energy in Response to Request for Information: Addressing Policy and Logistical Challenges to Smart Grid Implementation Issued September 13, 2010 FR Doc. 2010-23251 November 30, 2010 Cisco Systems provides these Comments in response to the Request for Information ("RFI") issued by the Office of Electricity Delivery and Energy Reliability of the Department of Energy ("DOE") on

  20. Gaseous Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Gaseous Hydrogen Delivery Gaseous hydrogen is most commonly delivered either by trucks or through pipelines. Because gaseous hydrogen is typically produced at relatively low pressures (20-30 bar), it must be compressed prior to transport. Learn more about gaseous hydrogen compression. Trucks that haul gaseous hydrogen are called tube trailers. Gaseous hydrogen is compressed to pressures of 180 bar (~2,600 psig) or higher into long cylinders which are stacked on the trailer that the

  1. ELECTRICITY DELIVERY AND ENERGY RELIABILITY Appropriation Overview

    Office of Environmental Management (EM)

    DELIVERY AND ENERGY RELIABILITY Appropriation Overview Electricity Delivery and Energy Reliability (OE) leads the Department's efforts to strengthen, transform, and improve our energy infrastructure so that consumers have access to reliable, secure, and clean sources of energy. To accomplish this critical mission, the Office works with private industry and Federal, state, local, and tribal governments on a variety of initiatives to modernize the electric grid. Grid modernization is critical to

  2. TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)

    SciTech Connect (OSTI)

    Dunne, A M

    2010-11-30

    The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition scheme is an essential component of an acceptably low-risk solution. The degree of coupling seen on NIF between driver and target performance mandates that little deviation be adopted from the NIF geometry and beamline characteristics. Similarly, the strong coupling between subsystems in an operational power plant mandates that a self-consistent solution be established via an integrated facility delivery project. The benefits of separability of the subsystems within an IFE plant (driver, chamber, targets, etc.) emerge in the operational phase of a power plant rather than in its developmental phase. An optimized roadmap for IFE delivery needs to account for this to avoid nugatory effort and inconsistent solutions. For LIFE, a system design has been established that could lead to an operating power plant by the mid-2020s, drawing from an integrated subsystem development program to demonstrate the required technology readiness on a time scale compatible with the construction plan. Much technical development work still remains, as does alignment of key stakeholder groups to this newly emerging development option. If the required timeline is to be met, then preparation of a viable program is required alongside the demonstration of ignition on NIF. This will enable timely analysis of the technical and economic case and establishment of the appropriate delivery partnership.

  3. Production Target Design Report

    SciTech Connect (OSTI)

    Woloshun, Keith Albert; Dale, Gregory E.; Olivas, Eric Richard

    2015-07-28

    The Northstar 99Mo production target, a cylindrical length of 100Mo rod, has evolved considerably since its first conception.The cylinder was very early sliced into disks to increase the heat transfer area, first to 1 mm thick disks then to the current 0.5 mm thick.The coolant was changed early in the target development from water to helium to eliminate corrosion and dissolution.The diameter has increased from initially 6 mm to 12 mm, the current diameter of the test target now at ANL, to nominally 28 mm (26-30.6 mm, depending upon optimal beam spot size and shape).The length has also changed to improve the production to cost ratio, so now the target is nominally 41 mm long (excluding coolant gaps between disks), and irradiated on both ends.This report summarizes the current status of the plant target design.

  4. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Agenda Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda Agenda for the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 PDF icon deliv_analysis_agenda.pdf More Documents & Publications Hydrogen Delivery Analysis Models Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Attendees List

  5. US DRIVE Hydrogen Delivery Technical Team Roadmap | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Technical Team Roadmap US DRIVE Hydrogen Delivery Technical Team Roadmap The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen. PDF icon hdtt_roadmap_june2013.pdf More Documents & Publications Hydrogen Delivery

  6. Cytometric Therapies for Cell Delivery - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Materials Advanced Materials Find More Like This Return to Search Cytometric Therapies for Cell Delivery Maximizing Efficacy of Cell Delivery Oak Ridge National Laboratory Contact ORNL About This Technology Technology Marketing Summary Stem cell therapies are a viable treatment options for some human diseases. Efficacy of such therapies can be maximized by addressing critical issues such as cell delivery and cell survival post delivery. Conventional methods for cell delivery do not

  7. Examination of Terminal Land Requirements for Hydrogen Delivery |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Examination of Terminal Land Requirements for Hydrogen Delivery Examination of Terminal Land Requirements for Hydrogen Delivery Presentation by Jerry Gillette of Argonne National Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 PDF icon deliv_analysis_gillette_landreq.pdf More Documents & Publications Hydrogen Delivery Analysis Models H2A Delivery Models and Results Hydrogen Pathways: Cost, Well-to-Wheels Energy Use, and

  8. Drug Detection Study

    Office of Scientific and Technical Information (OSTI)

    ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge ...

  9. Takeda Advances Diabetes Drug Development at the ALS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Takeda Advances Diabetes Drug Development at the ALS Print Type 2 diabetes mellitus (T2DM), characterized by abnormally high blood glucose levels, affects hundreds of millions of people worldwide. In the pursuit to better treat this disease, the human receptor protein GPR40 has been identified by pharmaceutical company Takeda as a potential new drug target. To this end, TAK-875 (fasiglifam), a partial agonist of GPR40, was brought into clinical development by Takeda as a possible new treatment

  10. Computer modeling reveals how surprisingly potent hepatitis C drug works

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy

  11. An Unusual Mechanism for the Antimicrobial Target Flavine-dependant

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Thymidylate Synthase (FTDS) An Unusual Mechanism for the Antimicrobial Target Flavine-dependant Thymidylate Synthase (FTDS) Classical thymidylate synthases, encoded by the thyA and TYMS genes, are present in most eukaryotes, including humans, and are frequently targeted by chemotherapeutic and antibiotic drugs. A recently discovered class of thymidylate synthases, the FDTSs encoded by the thyX gene has been found primarily in prokaryotes and viruses including several pathogens and biological

  12. Advanced Target Effects Modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Target Effects Modeling for Ion Accelerators and other High-Energy-Density Experiments Alice Koniges 1,a , Wangyi Liu 1 , Steven Lidia 1 , Thomas Schenkel 1 , John Barnard...

  13. Renewable energy delivery systems and methods

    DOE Patents [OSTI]

    Walker, Howard Andrew

    2013-12-10

    A system, method and/or apparatus for the delivery of energy at a site, at least a portion of the energy being delivered by at least one or more of a plurality of renewable energy technologies, the system and method including calculating the load required by the site for the period; calculating the amount of renewable energy for the period, including obtaining a capacity and a percentage of the period for the renewable energy to be delivered; comparing the total load to the renewable energy available; and, implementing one or both of additional and alternative renewable energy sources for delivery of energy to the site.

  14. Cryocompressed Hydrogen Storage and Liquid Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cryocompressed Hydrogen Storage & Liquid Delivery Jacob Leachman, Ph.D. Assistant Professor DOE H 2 Transmission & Delivery Workshop 2/26/2014 H Y P E R H drogen roperties for nergy esearch This presentation does not contain any proprietary, confidential, or otherwise restricted information. Jacob Leachman * DOE H 2 Transmission & Distribution Workshop * 2/25/2014 H Y P E R Why Cryogenic Hydrogen? * LH 2 tanker trucks delivered 80-90 % of total small merchant H 2 in 2010. 1 * Cryo-H

  15. Vulnerability Analysis of Energy Delivery Control Systems

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    0-18381 Vulnerability Analysis of Energy Delivery Control Systems September 2011 Idaho National Laboratory Idaho Falls, Idaho 83415 http://www.inl.gov Prepared for the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability Under DOE Idaho Operations Office Contract DE-AC07-05ID14517 The INL is a U.S. Department of Energy National Laboratory operated by Battelle Energy Alliance DISCLAIMER This information was prepared as an account of work sponsored by an agency of the

  16. Main chain acid-degradable polymers for the delivery of bioactive materials

    DOE Patents [OSTI]

    Frechet, Jean M. J.; Standley, Stephany M.; Jain, Rachna; Lee, Cameron C.

    2012-03-20

    Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.

  17. Time-Resolved SAXS/WAXS Study of the Phase Behavior and Microstructural Evolution of Drug/PEG Solid Dispersions

    SciTech Connect (OSTI)

    Zhu, Qing; Harris, Michael T.; Taylor, Lynne S.

    2013-03-07

    Simultaneous small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) was employed to elucidate the physical state and location of various small molecule drugs blended with polyethylene glycol (PEG), as well as the time dependent microstructural evolution of the systems. Samples were prepared by comelting physical mixtures of the drug and PEG, followed by solidification at 25 C. The model drugs selected encompassed a wide variety of physicochemical properties in terms of crystallization tendency and potential for interaction with PEG. It was observed that compounds which crystallized rapidly and had weak interactions with PEG tended to be excluded from the interlamellar region of the PEG matrix. In contrast, drugs which had favorable interactions with PEG were incorporated into the interlamellar regions of the polymer up until the point at which the drug crystallized whereby phase separation occurred. These factors are likely to impact the effectiveness of drug/PEG systems as drug delivery systems.

  18. Hydraulic Hybrid and Conventional Parcel Delivery Vehicles' Measured Laboratory Fuel Economy on Targeted Drive Cycles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hybrid drivetrains have shown signifcant promise as part of an overall petroleum reduction feet strategy [1, 2, 3, 4, 5, 6]. Hybrid drivetrains consist of an energy storage device and a motor integrated into a traditional powertrain and offer the potential fuel savings by capturing energy normally lost during deceleration through the application of regenerative braking. Because hybrid technologies, especially hydraulic hybrids, have low adoption rates in the medium-duty vehicle segment and

  19. Targeted polypeptide degradation

    DOE Patents [OSTI]

    Church, George M.; Janse, Daniel M.

    2008-05-13

    This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

  20. Foam encapsulated targets

    DOE Patents [OSTI]

    Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

    1983-01-01

    Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

  1. Energy-Efficient Melting and Direct Delivery of High Quality...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum PDF icon itmdelivery.pdf...

  2. Air Force Generic In-Kind Consideration Delivery Agreement |...

    Open Energy Info (EERE)

    Delivery Agreement Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: Air Force Generic In-Kind Consideration Delivery AgreementLegal...

  3. DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery High-Pressure Tanks and Analysis Project Review Meeting DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting On February 8-9, 2005, the Department ...

  4. Texas Natural Gas Exports (No Intransit Deliveries) (Million...

    U.S. Energy Information Administration (EIA) Indexed Site

    Exports (No Intransit Deliveries) (Million Cubic Feet) Texas Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5...

  5. Texas Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Texas Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

  6. West Virginia Heat Content of Natural Gas Deliveries to Consumers...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) West Virginia Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Year Jan Feb Mar Apr...

  7. West Virginia Natural Gas % of Total Residential Deliveries ...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    % of Total Residential Deliveries (Percent) West Virginia Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7...

  8. Connecticut Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Connecticut Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7...

  9. Cybersecurity for Energy Delivery Systems 2010 Peer Review

    Broader source: Energy.gov [DOE]

    National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day...

  10. DOE to Defer Strategic Petroleum Reserve RIK Deliveries | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    to Defer Strategic Petroleum Reserve RIK Deliveries DOE to Defer Strategic Petroleum Reserve RIK Deliveries June 5, 2008 - 12:51pm Addthis 2.1 Million Barrels Delayed Until Spring ...

  11. North Carolina Natural Gas % of Total Residential Deliveries...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    % of Total Residential Deliveries (Percent) North Carolina Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7...

  12. Vermont Natural Gas Deliveries to Electric Power Consumers (Million...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) Vermont Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  13. Alaska Natural Gas Deliveries to Electric Power Consumers (Million...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) Alaska Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  14. Maine Natural Gas Deliveries to Electric Power Consumers (Million...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) Maine Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  15. Iowa Natural Gas Deliveries to Electric Power Consumers (Million...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) Iowa Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  16. Florida Natural Gas Deliveries to Electric Power Consumers (Million...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Deliveries to Electric Power Consumers (Million Cubic Feet) Florida Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  17. New York Natural Gas Exports (No Intransit Deliveries) (Million...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    No Intransit Deliveries) (Million Cubic Feet) New York Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6...

  18. New York Natural Gas % of Total Residential Deliveries (Percent...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    % of Total Residential Deliveries (Percent) New York Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

  19. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Environmental Management (EM)

    Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry...

  20. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia...

  1. 2012 Annual Planning Summary for Electricity Delivery and Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Reliability | Department of Energy Electricity Delivery and Energy Reliability 2012 Annual Planning Summary for Electricity Delivery and Energy Reliability The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2012 and 2013 within Electricity Delivery and Energy Reliability. PDF icon APS-2012-OE.pdf More Documents & Publications 2011 Annual Planning Summary for Electricity Delivery and Energy Reliability (OE) EIS-0447: Amended Notice of Intent to

  2. Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology Presentation on inexpensive delivery of compressed hydrogen with advanced vessel technology. PDF icon wkshp_storage_berry.pdf More Documents & Publications President's Hydrogen Fuel Initiative Overview of FreedomCAR & Fuels Partnership/DOE Delivery Program High-Pressure Tube Trailers and Tanks

  3. Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Invited Guests | Department of Energy Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Presentation at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 PDF icon deliv_analysis_paster.pdf More Documents & Publications Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007,

  4. Hydrogen Delivery Options and Issues | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Options and Issues Hydrogen Delivery Options and Issues Presentation by DOE's Mark Paster at the 2010 - 2025 Scenario Analysis for Hydrogen Fuel Cell Vehicles and Infrastructure Meeting on August 9 - 10, 2006 in Washington, D.C. PDF icon paster_h2_delivery.pdf More Documents & Publications DOE and FreedomCAR and Fuels Partnership: Analysis Workshop H2A Delivery Models and Results Hydrogen Delivery Analysis Models

  5. Patricia Hoffman Assistant Secretary Office of Electricity Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Patricia Hoffman Assistant Secretary Office of Electricity Delivery and Energy ... Implementation Dear Assistant Secretary Hoffman, The Galvin Electricity Initiative ...

  6. Cybersecurity for Energy Delivery Systems (CEDS) Fact Sheets | Department

    Energy Savers [EERE]

    of Energy (CEDS) Fact Sheets Cybersecurity for Energy Delivery Systems (CEDS) Fact Sheets A key mission of the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is to enhance the reliability and resilience of the nation's energy infrastructure. Cybersecurity of energy delivery systems is critical for protecting the energy infrastructure and the integral function that it serves in our lives. OE's Cybersecurity for Energy Delivery Systems (CEDS) program

  7. Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis workshop. PDF icon wkshp_storage_agenda.pdf More Documents & Publications DOE and FreedomCAR and Fuels Partnership: Analysis Workshop DOE and FreedomCAR and Fuel Partnership Analysis Workshop Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda

  8. Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding

    Energy Savers [EERE]

    Natural Gas Operations | Department of Energy Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding Natural Gas Operations Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding Natural Gas Operations August 6, 2014 - 1:35pm Addthis A UPS delivery truck is refueled with compressed natural gas. UPS plans to deploy 1,000 liquefied natural gas vehicles. | Photo by Pat Corkery, National Renewable Energy Laboratory A UPS delivery truck is refueled with

  9. Patch and Update Management Program for Energy Delivery Systems

    Energy Savers [EERE]

    Patch and Update Management Program for Energy Delivery Systems A simplified process of patching and updating energy delivery system devices for end users and equipment vendors Background The energy sector places an emphasis on the availability and reliability of energy delivery operations. While best practice avoids the connection of energy delivery system devices to external networks, their increasing interconnectivity poses greater risk to cyber vulnerabilities. Proper and timely patches and

  10. National Electricity Delivery Division (NEDD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) Timely, accurate and defensible policy and market analysis is a key ingredient to building and sustaining successful programs at DOE. The National Electricity Delivery Division coordinates OE's policy-related activities which include: Coordination of Federal Transmission Authorizations Section 1221(a) of EPACT added section 216(h) to the Federal Power Act,

  11. Comments of Oncor Electric Delivery Company LLC | Department of Energy

    Office of Environmental Management (EM)

    Oncor Electric Delivery Company LLC Comments of Oncor Electric Delivery Company LLC Comments of Oncor Electric Delivery Company LLC on Implementing the National Broadband Plan by Studying the Communications Requirements of Electric Utilities to Inform Federal Smart Grid Policy PDF icon Comments of Oncor Electric Delivery Company LLC More Documents & Publications Current Communications Needs Future Communications Needs NBP RFI: Data Access, Third Party Use, and Privacy- Comments of Oncor

  12. Drug development and manufacturing

    DOE Patents [OSTI]

    Warner, Benjamin P.; McCleskey, T. Mark; Burrell, Anthony K.

    2015-10-13

    X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.

  13. NIF Target Shot Metrics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Target Shot Metrics Exp Cap - Experimental Capability Natl Sec Appl - National Security Applications DS - Discovery Science SSP_ICF - SSP Inertial Confinement Fusion SSP_HED - SSP High Energy Density SSP - Stockpile Stewardship Program For internal LLNL firewall viewing - if the page is blank, please open www.google.com to flush out BCB

  14. Streamline Service Delivery via Customer Communication and Contractor

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Coordination | Department of Energy Streamline Service Delivery via Customer Communication and Contractor Coordination Streamline Service Delivery via Customer Communication and Contractor Coordination Better Buildings Neighborhood Program Workforce Peer Exchange Call: Streamlining Service Delivery from the Customer's Perspective, Call Slides and Discussion Summary, August 30, 2012. PDF icon Call Slides and Discussion Summary More Documents & Publications Keeping It Simple from the

  15. Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Wu, Hong J.; Wang, Jun; Kang, Xinhuang; Zhang, Youyu; Lin, Yuehe

    2011-05-11

    Apoferritin is a nanostructured material with a uniform size and spherical structure, and it has excellent bio-compatibility. In this work, we report the use of apoferritin as a novel and biocompatible carrier for stabilizing enzymes and their activities. We used glucose oxidase (GOx) as a model enzyme. GOx was immobilized on the surface of the apoferritin through a green synthetic approach taking advantage of bioaffinity binding between streptavidin and biotin. As a result, a glucose oxidase-biotin/streptavidin/biotin-apoferritin conjugate (Apo-GOx) was prepared using streptavidin as a bridge. The synthesized Apo-GOx was characterized with transmission electron microscopy, ultraviolet, and fluorescence spectroscopy. The activity and stability of GOx on the surface of the apoferritin were studied in different environments, such as temperature, chemicals, and pH, in comparison with the biotinylated GOx (B-GOx). The results showed that the activity of GOx on the apoferritin surface was significantly enhanced. The thermal and chemical stability of the GOx on the apoferritin was also greatly improved compared to free B-GOx in a solution. It was found that the activity of the GOx on the apoferritin only lost 30% in comparison to a 70% loss of free B-GOx after a 2-hr incubation at 50oC. There was almost no decrease in activity for the GOx on the apoferritin as compared to an 80% activity decrease for free B-GOx after 30 minutes of incubation in a 5 M urea solution. The GOx immobilized apoferritin nanoparticles exhibited high sensitivity for glucose detection with a detection limit of 3 nM glucose. This work offers a novel approach for immobilizing enzymes with enhanced stability and activity, and this method may find a number of applications, such as in catalysis and bioassys/biosensors.

  16. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

    DOE Patents [OSTI]

    Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

    2014-07-22

    Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

  17. Realizing Technologies for Magnetized Target Fusion

    SciTech Connect (OSTI)

    Wurden, Glen A.

    2012-08-24

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  18. Shielded beam delivery apparatus and method

    DOE Patents [OSTI]

    Hershcovitch, Ady; Montano, Rory Dominick

    2006-07-11

    An apparatus includes a plasma generator aligned with a beam generator for producing a plasma to shield an energized beam. An electrode is coaxially aligned with the plasma generator and followed in turn by a vortex generator coaxially aligned with the electrode. A target is spaced from the vortex generator inside a fluid environment. The electrode is electrically biased relative to the electrically grounded target for driving the plasma toward the target inside a vortex shield.

  19. Turbomachine injection nozzle including a coolant delivery system

    DOE Patents [OSTI]

    Zuo, Baifang (Simpsonville, SC)

    2012-02-14

    An injection nozzle for a turbomachine includes a main body having a first end portion that extends to a second end portion defining an exterior wall having an outer surface. A plurality of fluid delivery tubes extend through the main body. Each of the plurality of fluid delivery tubes includes a first fluid inlet for receiving a first fluid, a second fluid inlet for receiving a second fluid and an outlet. The injection nozzle further includes a coolant delivery system arranged within the main body. The coolant delivery system guides a coolant along at least one of a portion of the exterior wall and around the plurality of fluid delivery tubes.

  20. Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Roadmap to Achieve Energy Delivery Systems Cybersecurity ii Acknowledgements The Energy Sector Control Systems Working Group (ESCSWG) developed this roadmap in support of the Electricity Sub-sector Coordinating Council, Oil and Natural Gas Sector Coordinating Council, and the Government Coordinating Council for Energy under the Critical Infrastructure Partnership Advisory Council (CIPAC) Framework; the roadmap has been approved for release by these councils. The ESCSWG members volunteered their

  1. Cybersecurity Procurement Language for Energy Delivery Systems

    Office of Environmental Management (EM)

    Cybersecurity Procurement Language for Energy Delivery Systems April 2014 Energy Sector Control Systems Working Group (ESCSWG) i For Questions or Comments Energy sector asset owners, operators, and suppliers are encouraged to provide feedback on this document to enhance the cybersecurity procurement language for future versions. Please send questions or comments to es-pl@energetics.com. Acknowledgements This document was prepared by the Energy Sector Control Systems Working Group (ESCSWG),

  2. Solvent recovery targeting

    SciTech Connect (OSTI)

    Ahmad, B.S.; Barton, P.I.

    1999-02-01

    One of the environmental challenges faced by the pharmaceutical and specialty chemical industries is the widespread use of organic solvents. With a solvent-based chemistry, the solvent necessarily has to be separated from the product. Chemical species in waste-solvent streams typically form multicomponent azeotropic mixtures, and this often complicates separation and, hence, recovery of solvents. A design approach is presented whereby process modifications proposed by the engineer to reduce the formation of waste-solvent streams can be evaluated systematically. This approach, called solvent recovery targeting, exploits a recently developed algorithm for elucidating the separation alternatives achievable when applying batch distillation to homogeneous multicomponent mixtures. The approach places the composition of the waste-solvent mixture correctly in the relevant residue curve map and computes the maximum amount of pure material that can be recovered via batch distillation. Solvent recovery targeting is applied to two case studies derived from real industrial processes.

  3. Waste feed delivery planning at Hanford

    SciTech Connect (OSTI)

    Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

    2013-01-10

    The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

  4. Apparatus for forming targets

    DOE Patents [OSTI]

    Woerner, Robert L. (Livermore, CA)

    1980-01-01

    Apparatus and method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  5. DOE Hydrogen and Fuel Cells Program Record 13013: Hydrogen Delivery Cost Projections - 2013

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen and Fuel Cells Program Record Record #: 13013 Date: September 26, 2013 Title: H 2 Delivery Cost Projections - 2013 Originator: E. Sutherland, A. Elgowainy and S. Dillich Approved by: R. Farmer and S. Satyapal Date: December 18, 2013 Item: Reported herein are past 2005 and 2011 estimates, current 2013 estimates, 2020 projected cost estimates and the 2015 and 2020 target costs for delivering and dispensing (untaxed) H 2 to 10%- 15% of vehicles within a city population of 1.2M from a

  6. Real time sensor for therapeutic radiation delivery

    DOE Patents [OSTI]

    Bliss, M.; Craig, R.A.; Reeder, P.L.

    1998-01-06

    The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body. 14 figs.

  7. Gas-phase propane fuel delivery system

    SciTech Connect (OSTI)

    Clements, J.

    1991-04-30

    This patent describes a gas-phase fuel delivery system for delivering a vapor phase fuel independent of exterior temperatures. It comprises:a storage tank for storing a volume of fuel; a regulator in fluid communication with the tank for receiving fuel from the tank and for outputting the fuel in a vapor phase; a pressure sensor in fluid communication with the tank for monitoring pressure within the tank, the pressure sensor being operative to generate a pump enable signal when the pressure within the tank is less than a predetermined threshold; a pump in fluid communication with the tank.

  8. Real time sensor for therapeutic radiation delivery

    DOE Patents [OSTI]

    Bliss, Mary (West Richland, WA); Craig, Richard A. (West Richland, WA); Reeder, Paul L. (Richland, WA)

    1998-01-01

    The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body.

  9. Alane for Hydrogen Storage and Delivery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alane for Hydrogen Storage and Delivery June 2012 BROOKHAVEN NATIONAL LABORATORY Why Hydrogen? * Oil is a limited resource, generates green house gas and much of the worlds supply lies outside the U.S. * 1 lb of hydrogen has the same energy as 3 lbs of gasoline 2 H 2 O H 2 O ...only emission is water (H 2 O) Hydrogen is a clean fuel and produces no CO 2 Hydrogen---powered fuel cells can supply energy to power a nything f rom a utomobiles t o h omes t o computers. 3 BROOKHAVEN NATIONAL LABORATORY

  10. Fuel Cell Technologies Program: Delivery Fact Sheet

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Distribution and Delivery Most of the hydrogen used in the U.S. is produced at or near where it is used - typically at large industrial sites. As a result, an efficient means of delivering large quantities of hydrogen fuel over long distances and at low cost does not yet exist. Before hydrogen can become a mainstream energy carrier, we must first develop and build the infrastructure (e.g. the miles of transmission and distribu- tion pipelines, bulk storage vessels, and refueling stations) that

  11. Target: Subpoena (2010-SE-2001)

    Broader source: Energy.gov [DOE]

    DOE issued a Subpoena for Information and Production of Documents to Target Corporation requesting information regarding the compliance of various torchieres Target has distributed in commerce in the U.S.

  12. Vulnerability Analysis of Energy Delivery Control Systems (September 2011)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Systems (September 2011) Vulnerability Analysis of Energy Delivery Control Systems (September 2011) The Vulnerability Analysis of Energy Delivery Control Systems report, prepared by Idaho National Laboratory, describes the common vulnerabilities on energy sector control systems, and provides recommendations for vendors and owners of those systems to identify and reduce those risks. PDF icon Vulnerability Analysis of Energy Delivery Control Systems (September 2011) More

  13. Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Achieve Energy Delivery Systems Cybersecurity - 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 As part of the Obama Administration's goals to enhance the security and reliability of the Nation's energy infrastructure, the U.S. Department of Energy released the 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity. Developed as an update to the 2006 Roadmap to Secure Control Systems in the Energy Sector, the report outlines a strategic

  14. Secretary Chu's Remarks as Prepared for Delivery at the Washington

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    University Commencement | Department of Energy as Prepared for Delivery at the Washington University Commencement Secretary Chu's Remarks as Prepared for Delivery at the Washington University Commencement May 21, 2010 - 12:00am Addthis Remarks of Secretary Steven Chu- As Prepared for Delivery Washington University Friday, May 21, 2010 Chancellor Mark Wrighton, the Board of Trustees, faculty, family, and friends here today, thank you for letting me share this wonderful day with you. It is a

  15. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Attendees

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    List | Department of Energy Attendees List Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Attendees List Attendee list from the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 PDF icon deliv_analysis_attendees.pdf More Documents & Publications DOE and FreedomCAR and Fuel Partnership Analysis Workshop Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda DOE and FreedomCAR and Fuel Partnership Analysis Workshop

  16. Cybersecurity Procurement Language for Energy Delivery (April 2014) |

    Energy Savers [EERE]

    Department of Energy Procurement Language for Energy Delivery (April 2014) Cybersecurity Procurement Language for Energy Delivery (April 2014) Energy delivery systems, which are used to monitor and control the production, transfer, and distribution of energy, are critical to the effective and reliable operation of North America's energy infrastructure. Our twenty-first-century way of life is made possible by the vast network of processes enabled by these systems, as well as the

  17. Percentage of Total Natural Gas Commercial Deliveries included in Prices

    Gasoline and Diesel Fuel Update (EIA)

    City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area Jul-15 Aug-15 Sep-15 Oct-15 Nov-15 Dec-15 View History U.S.

  18. Potential Carriers and Approaches for Hydrogen Delivery | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Carriers and Approaches for Hydrogen Delivery Potential Carriers and Approaches for Hydrogen Delivery Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 PDF icon deliv_analysis_hooks_carriers.pdf More Documents & Publications Summary of On-Board Storage Models and Analyses Analyses of Hydrogen Storage Materials and On-Board Systems Hydrogen Storage Systems Anlaysis Working Group Meeting, December 12, 2006

  19. Percentage of Total Natural Gas Industrial Deliveries included in Prices

    U.S. Energy Information Administration (EIA) Indexed Site

    Pipeline and Distribution Use Price City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Vehicle Fuel Price Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area 2010

  20. Percentage of Total Natural Gas Industrial Deliveries included in Prices

    U.S. Energy Information Administration (EIA) Indexed Site

    City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area Jul-15 Aug-15 Sep-15 Oct-15 Nov-15 Dec-15 View History U.S.

  1. Percentage of Total Natural Gas Residential Deliveries included in Prices

    U.S. Energy Information Administration (EIA) Indexed Site

    City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area Jul-15 Aug-15 Sep-15 Oct-15 Nov-15 Dec-15 View History U.S.

  2. Categorical Exclusion Determinations: Office of Electricity Delivery and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Reliability | Department of Energy Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations: Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations issued by Electricity Delivery and Energy Reliability. DOCUMENTS AVAILABLE FOR DOWNLOAD September 18, 2012 CX-009236: Categorical Exclusion Determination Dynasty Power, Inc. Export Authorization CX(s) Applied: B4.2 Date: 09/18/2012 Location(s): Canada Offices(s):

  3. Office of Electricity Delivery And Energy Reliability To Hold Technical

    Energy Savers [EERE]

    Conference On The Design Of Future Electric Transmission | Department of Energy Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission February 5, 2009 - 10:57am Addthis On March 4, 2009, the Department of Energy's Office of Electricity Delivery and Energy Reliability (OE) will conduct a

  4. April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure

    Energy Savers [EERE]

    Initiative FOA | Department of Energy April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure Initiative FOA April 7 Webinar on OE's Resilient Electricity Delivery Infrastructure Initiative FOA March 23, 2015 - 10:25am Addthis On April 7, Dan Ton, Acting Deputy Assistant Secretary, Dr. Imre Gyuk, Manager of the Energy Storage Program, and Dr. Carol Hawk, Manager of the Cybersecurity for Energy Delivery Systems Program, will be featured speakers during a webinar on OE's

  5. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Office of Environmental Management (EM)

    Best Practice Design/Configuration | Department of Energy Practice Design/Configuration Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practice Design/Configuration National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance

  6. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Office of Environmental Management (EM)

    Best Practices/Standards Development | Department of Energy Practices/Standards Development Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practices/Standards Development National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to

  7. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Office of Environmental Management (EM)

    Secure Communications | Department of Energy Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of

  8. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Office of Environmental Management (EM)

    Software Engineering Institute | Department of Energy Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the

  9. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Office of Environmental Management (EM)

    Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) | Department of Energy Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to

  10. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Office of Environmental Management (EM)

    Visualization and Modeling | Department of Energy Visualization and Modeling Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and

  11. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -

    Office of Environmental Management (EM)

    Vulnerability and Intrusion Detection | Department of Energy Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects

  12. National Electric Delivery Technologies Roadmap: Transforming the Grid to

    Office of Environmental Management (EM)

    Revolutionize Electric Power in North America | Department of Energy Delivery Technologies Roadmap: Transforming the Grid to Revolutionize Electric Power in North America National Electric Delivery Technologies Roadmap: Transforming the Grid to Revolutionize Electric Power in North America This Roadmap provides a framework for all of the stakeholders that comprise the electric industry to work together to achieve common aims. PDF icon National Electric Delivery Technologies Roadmap:

  13. Materials Solutions for Hydrogen Delivery in Pipelines | Department of

    Office of Environmental Management (EM)

    Energy Solutions for Hydrogen Delivery in Pipelines Materials Solutions for Hydrogen Delivery in Pipelines Objective: Develop materials technologies to minimize embrittlement of steels used for high-pressure transport of hydrogen PDF icon pipeline_group_das_ms.pdf More Documents & Publications Materials Solutions for Hydrogen Delivery in Pipelines American Society of Mechanical Engineers/Savannah River National Laboratory (ASME/SRNL) Materials and Components for Hydrogen Infrastructure

  14. Electromagnetic targeting of guns

    SciTech Connect (OSTI)

    Pogue, E.W.; Boat, R.M.; Holden, D.N.; Lopez, J.R.

    1996-10-01

    This is the final report of a one-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Electromagnetic pulse (EMP) signals produced from explosives being fired have been reported in the literature for fifty years. When a gun is fired it produces an EMP muzzle blast signal. The strength and nature of these signals was first analyzed in the early 1970s, while the results were interesting, no follow-up studies were conducted. With modern detection and signal processing technology, we believe that these signals could be used to instantaneously locate guns of virtually all calibers as they fire. The objective of our one-year project was to establish the basic nature of these signals and their utility in the concept of electromagnetic targeting of guns.

  15. Target detection portal

    DOE Patents [OSTI]

    Linker, Kevin L. (Albuquerque, NM); Brusseau, Charles A. (Tijeras, NM)

    2002-01-01

    A portal apparatus for screening persons or objects for the presence of trace amounts of target substances such as explosives, narcotics, radioactive materials, and certain chemical materials. The portal apparatus can have a one-sided exhaust for an exhaust stream, an interior wall configuration with a concave-shape across a horizontal cross-section for each of two facing sides to result in improved airflow and reduced washout relative to a configuration with substantially flat parallel sides; air curtains to reduce washout; ionizing sprays to collect particles bound by static forces, as well as gas jet nozzles to dislodge particles bound by adhesion to the screened person or object. The portal apparatus can be included in a detection system with a preconcentrator and a detector.

  16. Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Presentation at the Joint...

  17. Office of Electricity Delivery & Energy Reliability FY 2012 Budget...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    & Energy Reliability FY 2012 Budget Request Presentation Presentation by Patricia Hoffman of the Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request....

  18. Hydrogen Delivery Technologies and Systems- Pipeline Transmission of Hydrogen

    Broader source: Energy.gov [DOE]

    Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen. Design and operations standards and materials for hydrogen and natural gas pipelines.

  19. Oncor Electric Delivery - Solar Photovoltaic Standard Offer Program...

    Broader source: Energy.gov (indexed) [DOE]

    Summary Oncor Electric Delivery offers rebates to its customers that install photovoltaic (PV) systems on homes or other buildings.* Oncor customers of all rate classes...

  20. Vectren Energy Delivery of Indiana (Gas) - Commercial Energy...

    Broader source: Energy.gov (indexed) [DOE]

    350 Programmable Thermostat: 20 Commercial Kitchen Equipment: Varies Summary Vectren Energy Delivery offers commercial natural gas customers in Indiana rebates for the...

  1. ,"Maine Natural Gas Exports (No Intransit Deliveries) (Million...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Maine Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)",1,"Annual",2014...

  2. Vehicle Technologies Office - AVTA: All Electric Delivery Trucks...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from Smith Newton all-electric delivery trucks in a variety of fleets. This research was conducted by the National Renewable Energy Laboratory (NREL). PDF icon Smith Newton ...

  3. Vectren Energy Delivery of Indiana (Electric)- Commercial New Construction Rebates

    Broader source: Energy.gov [DOE]

    Vectren Energy Delivery offers commercial customers in Indiana electric rebates for the installation of certain types of equipment in newly constructed buildings through its Energy Design Assist...

  4. Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines Project Objectives: To gain basic understanding of hydrogen permeation behavior and its impact on hydrogen ...

  5. Office of Electricity Delivery & Energy Reliability FY 2012 Budget...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Presentation by Patricia Hoffman of the Office of Electricity Delivery & Energy ... FY16 OE Budget Request Presentation by Patricia Hoffman FY 2012 Budget Control Table for ...

  6. Lighting and Electrical Team Leadership and Project Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Lighting and Electrical Team Leadership and Project Delivery 2014 Building Technologies ... million sq ft of high efficiency parking lighting by February 2014 2. LEEP: 300 million sq ...

  7. Lighting and Electrical Team Leadership and Project Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO Peer Review Project Objective The partners involved in the Lighting Energy Efficiency in Parking (LEEP) ...

  8. Oncor Electric Delivery Company LLC | Open Energy Information

    Open Energy Info (EERE)

    Oncor Electric Delivery Company LLC Abbreviation: Oncor Place: Dallas, Texas Zip: 75202 Service Territory: Texas Phone Number: 1.888.313.6862 ParentHolding Organization: Energy...

  9. Oncor Electric Delivery Company, LLC Smart Grid Demonstration...

    Open Energy Info (EERE)

    Grid Demonstration Project Jump to: navigation, search Project Lead Oncor Electric Delivery Company, LLC Country United States Headquarters Location Dallas, Texas Recovery Act...

  10. Oncor Electric Delivery - Commercial and Industrial Rebate Program...

    Broader source: Energy.gov (indexed) [DOE]

    Contact Oncor Program Info Sector Name Utility Administrator Oncor Electric Delivery Website http:www.takealoadofftexas.comindex.aspx?idcommercial-standard-offer...

  11. Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PDF icon wkshpstorageberry.pdf More Documents & Publications President's Hydrogen Fuel Initiative Overview of FreedomCAR & Fuels PartnershipDOE Delivery Program High-Pressure ...

  12. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...

    Broader source: Energy.gov (indexed) [DOE]

    in-depth comparative analysis of promising infrastructure options for hydrogen delivery and distribution to refueling stations from central, semi-central, and distributed...

  13. Natural Gas Deliveries to Commercial Consumers (Including Vehicle...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    West Virginia (Million Cubic Feet) Natural Gas Deliveries to Commercial Consumers (Including Vehicle Fuel through 1996) in West Virginia (Million Cubic Feet) Year Jan Feb Mar Apr...

  14. Microsoft Word - Remarks as Prepared for Delivery for Assistant...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delivery for Assistant Secretary for Nuclear Energy Dennis R. Spurgeon Second Annual ... of capital, and ultimately lowering the cost of clean nuclear power to the consumer. ...

  15. Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results

    Broader source: Energy.gov [DOE]

    This presentation by Amgad Elgowainy of Argonne National Laboratory was given at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007.

  16. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback...

  17. ,"North Carolina Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","North Carolina Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  18. ,"West Virginia Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","West Virginia Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  19. ,"South Dakota Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","South Dakota Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  20. ,"New Jersey Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","New Jersey Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  1. ,"New York Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","New York Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  2. ,"South Carolina Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","South Carolina Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  3. ,"North Dakota Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","North Dakota Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  4. ,"Rhode Island Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","Rhode Island Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  5. ,"New Hampshire Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) Indexed Site

    Of Series","Frequency","Latest Data for" ,"Data 1","New Hampshire Natural Gas Deliveries to Electric Power Consumers (MMcf)",1,"Monthly","102015" ,"Release...

  6. DOE Office of Electricity Delivery & Energy Reliability (OE)...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delivery & Energy Reliability (OE) Energy Storage Safety Workshop - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & ...

  7. Joint Meeting on Hydrogen Delivery Modeling and Analysis, May...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Analysis, May 8-9, 2007, Discussion Session Highlights, Comments, and Action Items Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007, Discussion...

  8. Two-dimensional inverse planning and delivery with a preclinical image guided microirradiator

    SciTech Connect (OSTI)

    Stewart, James M. P.; Lindsay, Patricia E.; Jaffray, David A.; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9; Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9; The Techna Institute for the Advancement of Technology for Health, Toronto, Ontario M5G 1P5

    2013-10-15

    Purpose: Recent advances in preclinical radiotherapy systems have provided the foundation for scaling many of the elements of clinical radiation therapy practice to the dimensions and energy demanded in small animal studies. Such systems support the technical capabilities to accurately deliver highly complex dose distributions, but methods to optimize and deliver such distributions remain in their infancy. This study developed an optimization method based on empirically measured two-dimensional dose kernel measurements to deliver arbitrary planar dose distributions on a recently developed small animal radiotherapy platform.Methods: A two-dimensional dose kernel was measured with repeated radiochromic film measurements for the circular 1 mm diameter fixed collimator of the small animal radiotherapy system at 1 cm depth in a solid water phantom. This kernel was utilized in a sequential quadratic programming optimization framework to determine optimal beam positions and weights to deliver an arbitrary desired dose distribution. The positions and weights were then translated to a set of stage motions to automatically deliver the optimized dose distribution. End-to-end efficacy of the framework was quantified through five repeated deliveries of two dosimetric challenges: (1) a 5 mm radius bullseye distribution, and (2) a sock distribution contained within a 9 13 mm bounding box incorporating rectangular, semicircular, and exponentially decaying geometric constructs and a rectangular linear dose gradient region. These two challenges were designed to gauge targeting, geometric, and dosimetric fidelity.Results: Optimization of the bullseye and sock distributions required 2.1 and 5.9 min and utilized 50 and 77 individual beams for delivery, respectively. Automated delivery of the resulting optimized distributions, validated using radiochromic film measurements, revealed an average targeting accuracy of 0.32 mm, and a dosimetric delivery error along four line profiles taken through the sock distribution of 3.9%. Mean absolute delivery error across the 01 Gy linear dose gradient over 7.5 mm was 0.01 Gy.Conclusions: The work presented here demonstrates the potential for complex dose distributions to be planned and automatically delivered with millimeter scale heterogeneity at submillimeter accuracy. This capability establishes the technical foundation for preclinical validation of biologically guided radiotherapy investigations and development of unique radiobiological experiments.

  9. Synthesis and characterization of pharmaceutical surfactant templated mesoporous silica: Its application to controlled delivery of duloxetine

    SciTech Connect (OSTI)

    Mani, Ganesh; Pushparaj, Hemalatha; Peng, Mei Mei; Muthiahpillai, Palanichamy; Udhumansha, Ubaidulla; Jang, Hyun Tae

    2014-03-01

    Graphical abstract: - Highlights: Usefulness of dual pharmaceutical surfactants in silica synthesis was evaluated. Effects of concentration of secondary template (Tween-40) were studied. Effects of fixed solvothermal condition on mesostructure formation were studied. Duloxetine drug loading capability was studied. Sustained release of duloxetine was evaluated. - Abstract: A new group of mesoporous silica nanoparticles (MSNs) were synthesized using combination pharmaceutical surfactants, Triton X-100 and Tween-40 as template and loaded with duloxetine hydrochloride (DX), for improving the sustained release of DX and patterns with high drug loading. Agglomerated spherical silica MSNs were synthesized by solgel and solvothermal methods. The calcined and drug loaded MSNs were characterized using X-ray diffraction (XRD), BraunnerEmmettTeller (BET), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), diffuse reflectance ultravioletvisible (DRS-UVvis) spectroscopy. MSNs with high surface area and pore volume were selected and studied for their DX loading and release. The selected MSNs can accommodate a maximum of 34% DX within it. About 90% was released at 200 h and hence, the synthesized MSNs were capable of engulfing DX and sustain its release. Further form the Ritger and Peppas, Higuchi model for mechanism drug release from all the MSN matrices follows anomalous transport or Non-Fickian diffusion with the r and n value 0.9 and 0.45 < n < 1, respectively. So, from this study it could be concluded that the MSNs synthesized using pharmaceutical templates were better choice of reservoir for the controlled delivery of drug which requires sustained release.

  10. Enterprise Assessments Targeted Review of the Targeted Review...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Review of the Targeted Review of the Safety Significant Ventilation System and Interconnected Portions of the Associated Safety Class Confinement System, and Review of Federal ...

  11. California Save Energy Now: State, Regional, and Local Delivery

    Broader source: Energy.gov [DOE]

    California Save Energy Now: State, Regional, and Local Delivery utilized the state award from AMO to deliver a comprehensive package of training and assistance services to meet state industrial efficiency goals. The program was supported by state, regional, and local delivery partners.

  12. MEMORANDUM TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Environmental Management (EM)

    MEMORANDUM TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, U.S. Department of Energy FROM: Electricity Advisory Committee (EAC) Richard Cowart, Chair DATE: September 24, 2014 RE: Status and Recommendations for Electricity Delivery Workforce _________________________________________________________________________ Introduction In October, 2012 the EAC submitted a paper to the Secretary of the U.S. Department of Energy recommending actions that

  13. Facility target insert shielding assessment

    SciTech Connect (OSTI)

    Mocko, Michal

    2015-10-06

    Main objective of this report is to assess the basic shielding requirements for the vertical target insert and retrieval port. We used the baseline design for the vertical target insert in our calculations. The insert sits in the 12-diameter cylindrical shaft extending from the service alley in the top floor of the facility all the way down to the target location. The target retrieval mechanism is a long rod with the target assembly attached and running the entire length of the vertical shaft. The insert also houses the helium cooling supply and return lines each with 2 diameter. In the present study we focused on calculating the neutron and photon dose rate fields on top of the target insert/retrieval mechanism in the service alley. Additionally, we studied a few prototypical configurations of the shielding layers in the vertical insert as well as on the top.

  14. Micro injector sample delivery system for charged molecules

    DOE Patents [OSTI]

    Davidson, James C. (Livermore, CA); Balch, Joseph W. (Livermore, CA)

    1999-11-09

    A micro injector sample delivery system for charged molecules. The injector is used for collecting and delivering controlled amounts of charged molecule samples for subsequent analysis. The injector delivery system can be scaled to large numbers (>96) for sample delivery to massively parallel high throughput analysis systems. The essence of the injector system is an electric field controllable loading tip including a section of porous material. By applying the appropriate polarity bias potential to the injector tip, charged molecules will migrate into porous material, and by reversing the polarity bias potential the molecules are ejected or forced away from the tip. The invention has application for uptake of charged biological molecules (e.g. proteins, nucleic acids, polymers, etc.) for delivery to analytical systems, and can be used in automated sample delivery systems.

  15. Optical diagnostics integrated with laser spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

    2008-09-02

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  16. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, Douglas N. (Knoxville, TN)

    1996-01-01

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  17. Multiple target laser ablation system

    DOE Patents [OSTI]

    Mashburn, D.N.

    1996-01-09

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  18. Photosensitizer Conjugates For Pathogen Targeting

    DOE Patents [OSTI]

    Hasan, Tayyaba (Arlington, MA); Hamblin, Michael R. (Revere, MA); Soukos, Nikos (Revere, MA)

    2002-10-08

    Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.

  19. Flight Path Target 4 East Port

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 East Port Target 4 East Port Links Flight Path Overview Target 4 East Port About Target 4 East Port Collaborators Publications Links

  20. Drug Testing Notification | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Drug Testing Notification Drug Testing Notification PDF icon Drug Testing Notification More Documents & Publications Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Fact Sheet on the Consequences of a Positive Drug Test PSH-13-0022 - In the Matter of Personnel Security

  1. H2A Delivery Components Model and Analysis | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Components Model and Analysis H2A Delivery Components Model and Analysis Presentation on H2A Delivery Components Model and Analysis for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory PDF icon 05_ringer_h2a.pdf More Documents & Publications H2A Delivery Models and Results Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests

  2. FY 2012 Budget Control Table for the Office of Electricity Delivery...

    Energy Savers [EERE]

    FY 2012 Budget Control Table for the Office of Electricity Delivery and Energy Reliability FY 2012 Budget Control Table for the Office of Electricity Delivery and Energy...

  3. Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen

    Broader source: Energy.gov [DOE]

    Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen.Solid and liquid hydrogen carriers for use in hydrogen storage and delivery.

  4. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, David J. (Fremont, CA); Anex, Deon S. (Livermore, CA); Yan, Chao (Pleasanton, CA); Dadoo, Rajeev (Stanford, CA); Zare, Richard N. (Stanford, CA)

    1999-01-01

    Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

  5. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, D.J.; Anex, D.S.; Yan, C.; Dadoo, R.; Zare, R.N.

    1999-08-24

    Method and apparatus are disclosed for controlling precisely the composition and delivery of liquid at sub-{micro}L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-{micro}L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column. 4 figs.

  6. Enterprise Assessments, Lessons Learned from Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Lessons Learned from Targeted Reviews, Radiological Controls Activity-Level Implementation - January 2015 Enterprise Assessments, Lessons Learned from Targeted Reviews,...

  7. Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Transition and Long-term | Department of Energy Analysis, Options and Trade-offs, Transition and Long-term Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long-term Presentation on Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long-term for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory PDF icon 07_chen_nexant.pdf More Documents &

  8. Fluid Delivery System For Capillary Electrophoretic Applications.

    DOE Patents [OSTI]

    Li, Qingbo; Liu, Changsheng; Kane, Thomas E.; Kernan, John R.; Sonnenschein, Bernard; Sharer, Michael V.

    2002-04-23

    An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.

  9. Bounding Radionuclide Inventory and Accident Consequence Calculation for the 1L Target

    SciTech Connect (OSTI)

    Kelsey, Charles T. IV

    2011-01-01

    A bounding radionuclide inventory for the tungsten of the Los Alamos Neutron Science Center (LANSCE) IL Target is calculated. Based on the bounding inventory, the dose resulting from the maximum credible incident (MCI) is calculated for the maximally exposed offsite individual (MEOl). The design basis accident involves tungsten target oxidation following a loss of cooling accident. Also calculated for the bounding radionuclide inventory is the ratio to the LANSCE inventory threshold for purposes of inventory control as described in the target inventory control policy. A bounding radionuclide inventory calculation for the lL Target was completed using the MCNPX and CINDER'90 codes. Continuous beam delivery at 200 {micro}A to 2500 mA{center_dot}h was assumed. The total calculated activity following this irradiation period is 205,000 Ci. The dose to the MEOI from the MCI is 213 mrem for the bounding inventory. The LANSCE inventory control threshold ratio is 132.

  10. Electromagnetic Detection and Real-Time DMLC Adaptation to Target Rotation During Radiotherapy

    SciTech Connect (OSTI)

    Wu Junqing; Ruan, Dan; Cho, Byungchul; Sawant, Amit; Petersen, Jay; Newell, Laurence J.; Cattell, Herbert; Keall, Paul J.

    2012-03-01

    Purpose: Intrafraction rotation of more than 45 Degree-Sign and 25 Degree-Sign has been observed for lung and prostate tumors, respectively. Such rotation is not routinely adapted to during current radiotherapy, which may compromise tumor dose coverage. The aim of the study was to investigate the geometric and dosimetric performance of an electromagnetically guided real-time dynamic multileaf collimator (DMLC) tracking system to adapt to intrafractional tumor rotation. Materials/Methods: Target rotation was provided by changing the treatment couch angle. The target rotation was measured by a research Calypso system integrated with a real-time DMLC tracking system employed on a Varian linac. The geometric beam-target rotational alignment difference was measured using electronic portal images. The dosimetric accuracy was quantified using a two-dimensional ion chamber array. For each beam, the following five delivery modes were tested: 1) nonrotated target (reference); 2) fixed rotated target with tracking; 3) fixed rotated target without tracking; 4) actively rotating target with tracking; and 5) actively rotating target without tracking. Dosimetric performance of the latter four modes was measured and compared to the reference dose distribution using a 3 mm/3% {gamma}-test. Results: Geometrically, the beam-target rotational alignment difference was 0.3 Degree-Sign {+-} 0.6 Degree-Sign for fixed rotation and 0.3 Degree-Sign {+-} 1.3 Degree-Sign for active rotation. Dosimetrically, the average failure rate for the {gamma}-test for a fixed rotated target was 11% with tracking and 36% without tracking. The average failure rate for an actively rotating target was 9% with tracking and 35% without tracking. Conclusions: For the first time, real-time target rotation has been accurately detected and adapted to during radiation delivery via DMLC tracking. The beam-target rotational alignment difference was mostly within 1 Degree-Sign . Dose distributions to fixed and actively rotating targets with DMLC tracking were significantly superior to those without tracking.

  11. SU-E-T-107: Development of a GPU-Based Dose Delivery System for Adaptive Pencil Beam Scanning

    SciTech Connect (OSTI)

    Giordanengo, S; Russo, G; Marchetto, F; Attili, A; Monaco, V; Varasteh, M; Pella, A

    2014-06-01

    Purpose: A description of a GPU-based dose delivery system (G-DDS) to integrate a fast forward planning implementing in real-time the prescribed sequence of pencil beams. The system, which is under development, is designed to evaluate the dose distribution deviations due to range variations and interplay effects affecting mobile tumors treatments. Methods: The Dose Delivery System (DDS) in use at the Italian Centro Nazionale di Adroterapia Oncologica (CNAO), is the starting point for the presented system. A fast and partial forward planning (FP) tool has been developed to evaluate in few seconds the delivered dose distributions using the DDS data (on-line measurements of spot properties, i.e. number of particles and positions). The computation is performed during the intervals between synchrotron spills and, made available at the end of each spill. In the interval between two spills, the G-DDS will evaluate the delivered dose distributions taking into account the real-time target positions measured by a tracking system. The sequence of prescribed pencil beams for the following spill will be adapted taking into account the variations with respect to the original plan due to the target motion. In order to speed up the computation required to modify pencil beams distribution (up to 400 times has been reached), the Graphics Processing Units (GPUs) and advanced Field Programmable Gate Arrays (FPGAs) are used. Results: An existing offline forward planning is going to be optimized for the CUDA architecture: the gain in time will be presented. The preliminary performances of the developed GPU-based FP algorithms will be shown. Conclusion: A prototype of a GPU-based dose delivery system is under development and will be presented. The system workflow will be illustrated together with the approach adopted to integrate the three main systems, i.e. CNAO dose delivery system, fast forward planning, and tumor tracking system.

  12. Special Delivery for Sustainability: Clean Cities Supports UPS...

    Broader source: Energy.gov (indexed) [DOE]

    A UPS delivery truck is refueled with compressed natural gas. UPS plans to deploy 1,000 liquefied natural gas vehicles. | Photo by Pat Corkery, National Renewable Energy Laboratory ...

  13. Vacancy Announcements Posted for Hydrogen Production and Delivery Program

    Broader source: Energy.gov [DOE]

    The Fuel Cell Technologies Office has posted two vacancy announcements for a position to serve as Program Manager for the Hydrogen Production and Delivery Program in the DOE EERE Fuel Cell Technologies Office. The closing date is October 28, 2014.

  14. Joint Meeting on Hydrogen Delivery Modeling and Analysis

    Broader source: Energy.gov [DOE]

    On May 8-9, 2007, the U.S. Department of Energy (DOE) held a meeting to review current and ongoing hydrogen delivery analysis models and related analysis work. The presentations served as a...

  15. Natural Gas Deliveries to Commercial Consumers (Including Vehicle...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mexico (Million Cubic Feet) Natural Gas Deliveries to Commercial Consumers (Including Vehicle Fuel through 1996) in New Mexico (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul...

  16. Percent of Commercial Natural Gas Deliveries in North Carolina...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Represented by the Price (Percent) Percent of Commercial Natural Gas Deliveries in North Carolina Represented by the Price (Percent) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  17. NREL: Hydrogen and Fuel Cells Research - Hydrogen Production and Delivery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hydrogen Production and Delivery Learn how NREL is developing and advancing a number of pathways to renewable hydrogen production. Text Version Most of the hydrogen in the United States is produced by steam reforming of natural gas. For the near term, this production method will continue to dominate. Researchers at NREL are developing advanced processes to produce hydrogen economically from sustainable resources. NREL's hydrogen production and delivery R&D efforts, which are led by Huyen

  18. Office of Electricity Delivery and Energy Reliability (OE) National Energy

    Office of Scientific and Technical Information (OSTI)

    Technology Laboratory (NETL) American Recovery and Reinvestment Act 2009 United States Department of Energy (Technical Report) | SciTech Connect SciTech Connect Search Results Technical Report: Office of Electricity Delivery and Energy Reliability (OE) National Energy Technology Laboratory (NETL) American Recovery and Reinvestment Act 2009 United States Department of Energy Citation Details In-Document Search Title: Office of Electricity Delivery and Energy Reliability (OE) National Energy

  19. Hydraulic Hybrid Parcel Delivery Truck Deployment, Testing & Demonstration

    SciTech Connect (OSTI)

    Gallo, Jean-Baptiste

    2014-03-07

    Although hydraulic hybrid systems have shown promise over the last few years, commercial deployment of these systems has primarily been limited to Class 8 refuse trucks. In 2005, the Hybrid Truck Users Forum initiated the Parcel Delivery Working Group including the largest parcel delivery fleets in North America. The goal of the working group was to evaluate and accelerate commercialization of hydraulic hybrid technology for parcel delivery vehicles. FedEx Ground, Purolator and United Parcel Service (UPS) took delivery of the world’s first commercially available hydraulic hybrid parcel delivery trucks in early 2012. The vehicle chassis includes a Parker Hannifin hydraulic hybrid drive system, integrated and assembled by Freightliner Custom Chassis Corp., with a body installed by Morgan Olson. With funding from the U.S. Department of Energy, CALSTART and its project partners assessed the performance, reliability, maintainability and fleet acceptance of three pre-production Class 6 hydraulic hybrid parcel delivery vehicles using information and data from in-use data collection and on-road testing. This document reports on the deployment of these vehicles operated by FedEx Ground, Purolator and UPS. The results presented provide a comprehensive overview of the performance of commercial hydraulic hybrid vehicles in parcel delivery applications. This project also informs fleets and manufacturers on the overall performance of hydraulic hybrid vehicles, provides insights on how the technology can be both improved and more effectively used. The key findings and recommendations of this project fall into four major categories: -Performance, -Fleet deployment, -Maintenance, -Business case. Hydraulic hybrid technology is relatively new to the market, as commercial vehicles have been introduced only in the past few years in refuse and parcel delivery applications. Successful demonstration could pave the way for additional purchases of hydraulic hybrid vehicles throughout the trucking industry. By providing unbiased, third-party assessment of this “hybrid without batteries” technology, this report offers relevant, timely and valuable information to the industry.

  20. Massachusetts Save Energy Now-State, Local, and Regional Delivery |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Technical Assistance » State and Utility Engagement Activities » Massachusetts Save Energy Now-State, Local, and Regional Delivery Massachusetts Save Energy Now-State, Local, and Regional Delivery Massachusetts The U.S. Department of Energy's (DOE's) Advanced Manufacturing Office (AMO; formerly the Industrial Technologies Program) has developed multiple resources and a best practices suite of tools to help industrial manufacturers reduce their energy intensity. AMO

  1. Ammonia storage and delivery systems for NOx aftertreatment | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy storage and delivery systems for NOx aftertreatment Ammonia storage and delivery systems for NOx aftertreatment Poster presenation at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT). PDF icon deer07_johannessen.pdf More Documents & Publications 3rd Generation SCR System Using Solid Ammonia Storage and

  2. Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Energy Reliability, Before The United States House of Representatives Appropriations Subcommittee on Energy and Water Development, March 25, 2014 | Department of Energy Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, Before The United States House of Representatives Appropriations Subcommittee on Energy and Water Development, March 25, 2014 Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, Before

  3. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Energy Reliability, Before the US Senate Committee on Energy and Natural Resources, April 26, 2012 | Department of Energy Senate Committee on Energy and Natural Resources, April 26, 2012 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Before the US Senate Committee on Energy and Natural Resources, April 26, 2012 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, before the US Senate

  4. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Energy Reliability, before the House Appropriations Subcommittee on Energy and Water Development, March 30, 2011 | Department of Energy House Appropriations Subcommittee on Energy and Water Development, March 30, 2011 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, before the House Appropriations Subcommittee on Energy and Water Development, March 30, 2011 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and

  5. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Energy Reliability, before the Senate Committee Energy and Natural Resources, May 5, 2011 | Department of Energy before the Senate Committee Energy and Natural Resources, May 5, 2011 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, before the Senate Committee Energy and Natural Resources, May 5, 2011 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, before the Committee Energy and Natural

  6. Status and EAC Recommendations for Electricity Delivery Workforce

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (September 2014) | Department of Energy Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) This memo, approved at the September 2014 EAC meeting and delivered to the Department of Energy, reports on the activities since September 2013 of the Workforce Work Group and makes recommendations to the DOE. The recommendations include the development of a DOE response to an October 2012

  7. District of Columbia Natural Gas Deliveries to Electric Power Consumers

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (Million Cubic Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) District of Columbia Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 0 0 0 0 0 0 0 0 0 0 0 0 2002 0 0 0 0 0 0 0 0 0 0 0 0 2003 -- -- -- -- -- -- -- -- -- -- -- -- 2004 -- -- -- -- -- -- -- -- -- -- -- -- 2005 -- -- -- -- -- -- -- -- -- -- -- -- 2006 -- -- -- -- -- -- -- -- -- -- -- -- 2007 -- -- -- -- -- -- -- -- -- -- -- -- 2008

  8. Vehicle Technologies Office - AVTA: All Electric Delivery Trucks |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Delivery Trucks Vehicle Technologies Office - AVTA: All Electric Delivery Trucks The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a wide range of advanced vehicles and technologies on dynamometers, closed test tracks, and on-the-road. These results provide benchmark data that researchers can use to develop technology models and guide future research and development. The following set of reports (part of the medium and heavy-duty

  9. Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery Vehicles |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Delivery Vehicles Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery Vehicles The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a wide range of advanced vehicles and technologies on dynamometers, closed test tracks, and on-the-road. These results provide benchmark data that researchers can use to develop technology models and guide future research and development. The following set of reports (part of the medium and

  10. TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Energy Savers [EERE]

    TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, U.S. Department of Energy FROM: Electricity Advisory Committee (EAC) Richard Cowart, Chair DATE: September 25, 2014 RE: Expanding and Modernizing the Electric Power Delivery System for the 21 st Century Introduction The United States electricity system is undergoing more change than it has in many decades. The causes are numerous: a changing mix of resources driven by lowering prices, climate

  11. Tank Waste Feed Delivery System Readiness at the Hanford Site

    Energy Savers [EERE]

    Audit Report Tank Waste Feed Delivery System Readiness at the Hanford Site OAS-L-12-09 August 2012 Department of Energy Washington, DC 20585 August 23, 2012 MEMORANDUM FOR THE MANAGER, OFFICE OF RIVER PROTECTION FROM: David Sedillo, Director Western Audits Division Office of Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Tank Waste Feed Delivery System Readiness at the Hanford Site" BACKGROUND The Department of Energy's largest cleanup task

  12. Record of Categorical Exclusion (CX) Office of Electricity Delivery and

    Energy Savers [EERE]

    Energy Reliability (OE): EA-405 Del Norte Energy LLC | Department of Energy Office of Electricity Delivery and Energy Reliability (OE): EA-405 Del Norte Energy LLC Record of Categorical Exclusion (CX) Office of Electricity Delivery and Energy Reliability (OE): EA-405 Del Norte Energy LLC Application from Del Norte to export electric energy to Mexico. Record of Categorical Exclusion (CX) Determination. PDF icon EA-405 Del Norte Energy.pdf More Documents & Publications Record of

  13. Delivery system for molten salt oxidation of solid waste

    DOE Patents [OSTI]

    Brummond, William A. (Livermore, CA); Squire, Dwight V. (Livermore, CA); Robinson, Jeffrey A. (Manteca, CA); House, Palmer A. (Walnut Creek, CA)

    2002-01-01

    The present invention is a delivery system for safety injecting solid waste particles, including mixed wastes, into a molten salt bath for destruction by the process of molten salt oxidation. The delivery system includes a feeder system and an injector that allow the solid waste stream to be accurately metered, evenly dispersed in the oxidant gas, and maintained at a temperature below incineration temperature while entering the molten salt reactor.

  14. Office of Electricity Delivery and Energy Reliability Cyber Security

    Energy Savers [EERE]

    Project Selections | Department of Energy Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections On September 23, 2010, speaking at the inaugural GridWise Global Forum, U.S. Energy Secretary Steven Chu today announced the investment of more than $30 million for ten projects that will address cybersecurity issues facing the nation's electric grid. Together, these projects

  15. Office of Electricity Delivery and Energy Reliability Recovery Program Plan

    Energy Savers [EERE]

    | Department of Energy Electricity Delivery and Energy Reliability Recovery Program Plan Office of Electricity Delivery and Energy Reliability Recovery Program Plan PDF icon Microsoft Word - OE PSRP June 5 2009 _OE_ Final.doc More Documents & Publications Microsoft Word - PSRP Updates 6-25-10_v2 Update to the 2008 EAC Report: "Smart Grid: Enabler of the New Energy Economy Report Recommendations" Microsoft Word - PSRP Updates 6-25-10_v2

  16. Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO

    Energy Savers [EERE]

    Peer Review | Department of Energy Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO Peer Review Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO Peer Review Project Objective The partners involved in the Lighting Energy Efficiency in Parking (LEEP) campaign, along with private and public entities, advocate for and install energy-efficient lighting in public parking lots to foster significant reductions in participants' energy consumption. The

  17. Energy Infrastructure Office of Electricity Delivery and Energy Reliability

    Office of Environmental Management (EM)

    Comparing the Impacts of Northeast Hurricanes on Energy Infrastructure Office of Electricity Delivery and Energy Reliability U.S. Department of Energy April 2013 i For Further Information This report was prepared by the Office of Electricity Delivery and Energy Reliability under the direction of Patricia Hoffman, Assistant Secretary, and William Bryan, Deputy Assistant Secretary. Specific questions about this report may be directed to Alice Lippert, Acting Deputy Assistant Secretary, Energy

  18. Renewable Electricity Generation and Delivery at the Sacramento Municipal

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Utility District | Department of Energy Electricity Generation and Delivery at the Sacramento Municipal Utility District Renewable Electricity Generation and Delivery at the Sacramento Municipal Utility District Dairy digester and engine genset at New Hope dairy farm. | <em>Photo courtesy of Sacramento Municipal Utility District</em> Dairy digester and engine genset at New Hope dairy farm. | Photo courtesy of Sacramento Municipal Utility District The Sacramento Municipal Utility

  19. Hydrogen Distribution and Delivery Infrastructure Basics | Department of

    Office of Environmental Management (EM)

    Energy Education » Increase Your H2IQ » Hydrogen Distribution and Delivery Infrastructure Basics Hydrogen Distribution and Delivery Infrastructure Basics Most of the hydrogen used in the United States is produced at or very near where it is used-typically at large industrial sites. As a result, an efficient means of delivering large quantities of hydrogen fuel over long distances and at low cost does not yet exist. Before hydrogen can become a mainstream energy carrier, we must first

  20. Cybersecurity for Energy Delivery Systems (CEDS) Research Call | Department

    Office of Environmental Management (EM)

    of Energy Research Call Cybersecurity for Energy Delivery Systems (CEDS) Research Call April 15, 2014 - 10:15am Addthis The Department of Energy's (DOE) National Energy Technology Laboratory (NETL), on behalf of the Office of Electricity Delivery and Energy Reliability (OE), is seeking applications to conduct research, development and demonstrations leading to next generation tools and technologies that will become widely adopted to enhance and accelerate deployment of cybersecurity

  1. Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Energy Reliability, Before The United States House of Representatives Appropriations Subcommittee on Energy and Water Development, March 17, 2015 | Department of Energy Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, Before The United States House of Representatives Appropriations Subcommittee on Energy and Water Development, March 17, 2015 Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy

  2. Inertial-confinement-fusion targets

    SciTech Connect (OSTI)

    Hendricks, C.D.

    1982-08-10

    Much of the research in laser fusion has been done using simple ball on-stalk targets filled with a deuterium-tritium mixture. The targets operated in the exploding pusher mode in which the laser energy was delivered in a very short time (approx. 100 ps or less) and was absorbed by the glass wall of the target. The high energy density in the glass literally exploded the shell with the inward moving glass compressing the DT fuel to high temperatures and moderate densities. Temperatures achieved were high enough to produce DT reactions and accompanying thermonuclear neutrons and alpha particles. The primary criteria imposed on the target builders were: (1) wall thickness, (2) sphere diameter, and (3) fuel in the sphere.

  3. Ion beam inertial confinement target

    DOE Patents [OSTI]

    Bangerter, Roger O. (Danville, CA); Meeker, Donald J. (Livermore, CA)

    1985-01-01

    A target for implosion by ion beams composed of a spherical shell of frozen DT surrounded by a low-density, low-Z pusher shell seeded with high-Z material, and a high-density tamper shell. The target has various applications in the inertial confinement technology. For certain applications, if desired, a low-density absorber shell may be positioned intermediate the pusher and tamper shells.

  4. SciFri AM: Mountain 05: Unified Optimization and Delivery of Intensity-modulated Radiation Therapy and Volume-modulated Arc Therapy

    SciTech Connect (OSTI)

    Chen, J; Hoover, D; MacFarlane, M; Wong, E

    2014-08-15

    Purpose: To study the feasibility of a unified intensity-modulated arc therapy (UIMAT) that combines IMRT and VMAT optimization and delivery in order to produce efficient and superior radiation treatment plans. Methods: Inverse planning for UIMAT was prototyped on the Pinnacle treatment planning system (Philips Medical Systems). UIMAT integrates IMRT and VMAT delivery in the same arc where IMRT was delivered with gantry speed close to zero. Optimal gantry angles for the IMRT phases were selected automatically by the inverse optimization algorithm. Optimization of the VMAT phases and IMRT phases were done simultaneously using Pinnacle's direct machine parameter optimization algorithm. Five treatment plans each for prostate, head and neck, and lung were generated using our unified technique and compared with clinical VMAT or IMRT plans. Delivery verification was performed on an ArcCheck phantom (Sun Nuclear) and delivered in clinical mode on a Varian TrueBeam linear accelerator. Results: In this prototype implementation, compared to the VMAT or IMRT plans, with the plans normalized to the same dose coverage to the planning target volumes, the UIMAT plans produced improved OAR sparing for head and neck cases, while for lung and prostate cases, the dosimetric improvements for OARs were not as significant. In this proof-of-concept work, we demonstrated that a novel radiation therapy delivery technique combining VMAT and IMRT delivery in the same arc is feasible. Initial results showed UIMAT has the potential to be superior to either standard IMRT or VMAT.

  5. Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery (Presentation)

    SciTech Connect (OSTI)

    Jalalzadeh-Azar, A.

    2010-10-18

    This presentation summarizes "A Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery".

  6. Targeting NRF2 signaling for cancer chemoprevention

    SciTech Connect (OSTI)

    Kwak, Mi-Kyoung; Kensler, Thomas W.

    2010-04-01

    Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

  7. Targets and methods for target preparation for radionuclide production

    DOE Patents [OSTI]

    Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

    2012-10-16

    The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

  8. H2A Delivery: GH2 and LH2 Forecourt Land Areas | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    GH2 and LH2 Forecourt Land Areas H2A Delivery: GH2 and LH2 Forecourt Land Areas Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 PDF icon deliv_analysis_hooks_fc.pdf More Documents & Publications H2A Delivery: Forecourt Compression & Storage Optimization (Part II) H2A Delivery Models and Results Hydrogen Delivery Analysis Models

  9. H2A Delivery: Miscellaneous Cost and H2 Losses | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Miscellaneous Cost and H2 Losses H2A Delivery: Miscellaneous Cost and H2 Losses Presentation by Matt Ringer of the National Renewable Energy Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 PDF icon deliv_analysis_ringer.pdf More Documents & Publications H2A Delivery Models and Results Hydrogen Delivery Analysis Models H2A Delivery Components Model and Analysis

  10. Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Indiana Natural Gas Powers Milk Delivery Trucks in Indiana to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Twitter Bookmark Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Google Bookmark Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Delicious Rank

  11. NERSC Helps Physicists ID New Molecules With Unique Features

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    applications," they wrote. "These molecules can be used for targeted non-invasive drug delivery. When assembled, the molecules can also form new high strength magnets...

  12. Sandia R E S E A R H J

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... His dissertation research was on design and synthesis of self-assembled nanomaterials as vehicles for targeted drug delivery, tissue engineering and regenerative medicine. ...

  13. The CNAO dose delivery system for modulated scanning ion beam radiotherapy

    SciTech Connect (OSTI)

    Giordanengo, S.; Marchetto, F.; Garella, M. A.; Donetti, M.; Bourhaleb, F.; Monaco, V.; Hosseini, M. A.; Peroni, C.; Sacchi, R.; Cirio, R.; Ciocca, M.; Mirandola, A.

    2015-01-15

    Purpose: This paper describes the system for the dose delivery currently used at the Centro Nazionale di Adroterapia Oncologica (CNAO) for ion beam modulated scanning radiotherapy. Methods: CNAO Foundation, Istituto Nazionale di Fisica Nucleare and University of Torino have designed, built, and commissioned a dose delivery system (DDS) to monitor and guide ion beams accelerated by a dedicated synchrotron and to distribute the dose with a full 3D scanning technique. Protons and carbon ions are provided for a wide range of energies in order to cover a sizable span of treatment depths. The target volume, segmented in several layers orthogonally to the beam direction, is irradiated by thousands of pencil beams which must be steered and held to the prescribed positions until the prescribed number of particles has been delivered. For the CNAO beam lines, these operations are performed by the DDS. The main components of this system are two independent beam monitoring detectors, called BOX1 and BOX2, interfaced with two control systems performing the tasks of real-time fast and slow control, and connected to the scanning magnets and the beam chopper. As a reaction to any condition leading to a potential hazard, a DDS interlock signal is sent to the patient interlock system which immediately stops the irradiation. The essential tasks and operations performed by the DDS are described following the data flow from the treatment planning system through the end of the treatment delivery. Results: The ability of the DDS to guarantee a safe and accurate treatment was validated during the commissioning phase by means of checks of the charge collection efficiency, gain uniformity of the chambers, and 2D dose distribution homogeneity and stability. A high level of reliability and robustness has been proven by three years of system activity needing rarely more than regular maintenance and working with 100% uptime. Four identical and independent DDS devices have been tested showing comparable performances and are presently in use on the CNAO beam lines for clinical activity. Conclusions: The dose delivery system described in this paper is one among the few worldwide existing systems to operate ion beam for modulated scanning radiotherapy. At the time of writing, it has been used to treat more than 350 patients and it has proven to guide and control the therapeutic pencil beams reaching performances well above clinical requirements. In particular, in terms of dose accuracy and stability, daily quality assurance measurements have shown dose deviations always lower than the acceptance threshold of 5% and 2.5%, respectively.

  14. Materials considerations in accelerator targets

    SciTech Connect (OSTI)

    Peacock, H.B. Jr.; Iyer, N.C.; Louthan, M.R. Jr.

    1994-08-01

    Future nuclear materials production and/or the burn-up of long lived radioisotopes may be accomplished through the capture of spallation produced neutrons in accelerators. Aluminum clad-lead and/or lead alloys has been proposed as a spallation target. Aluminum was the cladding choice because of the low neutron absorption cross section, fast radioactivity decay, high thermal conductivity, and excellent fabricability. Metallic lead and lead oxide powders were considered for the target core with the fabrication options being casting or powder metallurgy (PM). Scoping tests to evaluate gravity casting, squeeze casting, and casting and swaging processes showed that, based on fabricability and heat transfer considerations, squeeze casting was the preferred option for manufacture of targets with initial core cladding contact. Thousands of aluminum clad aluminum-lithium alloy core targets and control rods for tritium production have been fabricated by coextrusion processes and successfully irradiated in the SRS reactors. Tritium retention in, and release from the coextruded product was modeled from experimental and operational data. Newly produced tritium atoms were trapped by lithium atoms to form a lithium tritide. The effective tritium pressure required for trap or tritide stability was the equilibrium decomposition pressure of tritium over a lithium tritide-aluminum mixture. The temperature dependence of tritium release was determined by the permeability of the cladding to tritium and the local equilibrium at the trap sites. The model can be used to calculate tritium release from aluminum clad, aluminum-lithium alloy targets during postulated accelerator operational and accident conditions. This paper describes the manufacturing technologies evaluated and presents the model for tritium retention in aluminum clad, aluminum-lithium alloy tritium production targets.

  15. Tank Farms and Waste Feed Delivery - 12507

    SciTech Connect (OSTI)

    Fletcher, Thomas; Charboneau, Stacy; Olds, Erik

    2012-07-01

    The mission of the Department of Energy's Office of River Protection (ORP) is to safely retrieve and treat the 56 million gallons of Hanford's tank waste and close the Tank Farms to protect the Columbia River. Our discussion of the Tank Farms and Waste Feed Delivery will cover progress made to date with Base and Recovery Act funding in reducing the risk posed by tank waste and in preparing for the initiation of waste treatment at Hanford. The millions of gallons of waste are a by-product of decades of plutonium production. After irradiated fuel rods were taken from the nuclear reactors to the processing facilities at Hanford they were exposed to a series of chemicals designed to dissolve away the rod, which enabled workers to retrieve the plutonium. Once those chemicals were exposed to the fuel rods they became radioactive and extremely hot. They also couldn't be used in this process more than once. Because the chemicals are caustic and extremely hazardous to humans and the environment, underground storage tanks were built to hold these chemicals until a more permanent solution could be found. The underground storage tanks range in capacity from 55,000 gallons to more than 1 million gallons. The tanks were constructed with carbon steel and reinforced concrete. There are eighteen groups of tanks, called 'tank farms', some having as few as two tanks and others up to sixteen tanks. Between 1943 and 1964, 149 single-shell tanks were built at Hanford in the 200 West and East Areas. Heat generated by the waste and the composition of the waste caused an estimated 67 of these single-shell tanks to leak into the ground. Washington River Protection Solutions is the prime contractor responsible for the safe management of this waste. WRPS' mission is to reduce the risk to the environment that is posed by the waste. All of the pumpable liquids have been removed from the single-shell tanks and transferred to the double-shell tanks. What remains in the single-shell tanks are solid and semi-solid wastes. Known as salt-cakes, they have the consistency of wet beach sand. Some of the waste resembles small broken ice, or whitish crystals. Because the original pumps inside the tanks were designed to remove only liquid waste, other methods have been developed to reach the remaining waste. Access to the tank waste is through long, typically skinny pipes, called risers, extending out of the tanks. It is through these pipes that crews are forced to send machines and devices into the tanks that are used to break up the waste or push it toward a pump. These pipes range in size from just a few inches to just over a foot in diameter because they were never intended to be used in this manner. As part of the agreement regulating Hanford cleanup, crews must remove at least 99% of the material in every tank on the site, or at least as much waste that can be removed based on available technology. To date, seven single-shell tanks have been emptied, and work is underway in another 10 tanks in preparation for additional retrieval activities. Two barriers have been installed over single-shell tanks to prevent the intrusion of surface water down to the tanks, with additional barriers planned for the future. Single and double-shell tank integrity analyses are ongoing. Because the volume of the waste generated through plutonium production exceeded the capacity of the single-shell tanks, between 1968 and 1986 Hanford engineers built 28 double-shell tanks. These tanks were studied and made with a second shell to surround the carbon steel and reinforced concrete. The double-shell tanks have not leaked any of their waste. (authors)

  16. Id-1 and Id-2 genes and products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    DOE Patents [OSTI]

    Desprez, Pierre-Yves; Campisi, Judith

    2014-09-30

    A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.

  17. Enterprise Assessments Lessons Learned from Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from Targeted Reviews of Fire Protection Programs at Department of Energy Facilities - August 2015 Enterprise Assessments Lessons Learned from Targeted Reviews of Fire ...

  18. A Prospective Target for Advanced Biofuel Production

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Prospective Target for Advanced Biofuel Production A Prospective Target for Advanced Biofuel Production Print Thursday, 02 February 2012 13:34 The sesquiterpene bisabolene was...

  19. Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: Plan quality, delivery efficiency and accuracy

    SciTech Connect (OSTI)

    Rao Min; Yang Wensha; Chen Fan; Sheng Ke; Ye Jinsong; Mehta, Vivek; Shepard, David; Cao Daliang

    2010-03-15

    Purpose: Helical tomotherapy (HT) and volumetric modulated arc therapy (VMAT) are arc-based approaches to IMRT delivery. The objective of this study is to compare VMAT to both HT and fixed field IMRT in terms of plan quality, delivery efficiency, and accuracy. Methods: Eighteen cases including six prostate, six head-and-neck, and six lung cases were selected for this study. IMRT plans were developed using direct machine parameter optimization in the Pinnacle{sup 3} treatment planning system. HT plans were developed using a Hi-Art II planning station. VMAT plans were generated using both the Pinnacle{sup 3} SmartArc IMRT module and a home-grown arc sequencing algorithm. VMAT and HT plans were delivered using Elekta's PreciseBeam VMAT linac control system (Elekta AB, Stockholm, Sweden) and a TomoTherapy Hi-Art II system (TomoTherapy Inc., Madison, WI), respectively. Treatment plan quality assurance (QA) for VMAT was performed using the IBA MatriXX system while an ion chamber and films were used for HT plan QA. Results: The results demonstrate that both VMAT and HT are capable of providing more uniform target doses and improved normal tissue sparing as compared with fixed field IMRT. In terms of delivery efficiency, VMAT plan deliveries on average took 2.2 min for prostate and lung cases and 4.6 min for head-and-neck cases. These values increased to 4.7 and 7.0 min for HT plans. Conclusions: Both VMAT and HT plans can be delivered accurately based on their own QA standards. Overall, VMAT was able to provide approximately a 40% reduction in treatment time while maintaining comparable plan quality to that of HT.

  20. U.S. Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    Deliveries (Percent) U.S. Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 100 100 100 100 100 100 100 2000's 100 100 100 100 100 100 100 100 100 100 2010's 100 100 100 100 100 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring Pages: Share of Total U.S. Natural Gas

  1. Fleet DNA Project Data Summary Report for Delivery Trucks

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    43 47 40 29 56 41 Deployment ID 0 100 200 300 400 500 553 Number of days Breakdown of Total Operational Days Collected by Deployment for Delivery Trucks 0% 20% 40% 60% 80% 100% # of Vehicles Reporting: 36 # of Days Included: 553 Generated: Thu Aug 07, 2014 43 40 47 29 41 56 Deployment ID 0 5 10 15 20 25 30 35 36 Number of Vehicles Breakdown of Total Vehicles by Deployment for Delivery Trucks 0% 20% 40% 60% 80% 100% # of Vehicles Reporting: 36 # of Days Included: 553 Generated: Thu Aug 07, 2014

  2. Fleet DNA Project Data Summary Report for Delivery Vans

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Number of days 974 800 600 400 200 0 37 3 5 54 52 36 7 6 50 51 1 22 23 4 53 55 57 48 49 60 Deployment ID Breakdown of Total Operational Days Collected by Deployment for Delivery Vans 100% 80% 60% 40% 20% 0% # of Vehicles Reporting: 94 Generated: Thu Aug 07, 2014 # of Days Included: 974 37 1 3 36 22 5 23 6 7 52 54 4 50 51 48 49 53 55 57 60 Deployment ID 0 20 40 60 80 94 Number of Vehicles Breakdown of Total Vehicles by Deployment for Delivery Vans 0% 20% 40% 60% 80% 100% # of Vehicles Reporting:

  3. Maine Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Exports (No Intransit Deliveries) (Million Cubic Feet) Maine Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 2000's 0 0 2,131 2010's 452 1,028 6,952 13,539 2,911 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring Pages: U.S. Natural Gas Exports Maine U.S. Natural Gas

  4. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

    1984-01-01

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reaction accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  5. Multishell inertial confinement fusion target

    DOE Patents [OSTI]

    Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

    1987-01-01

    A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reactions accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

  6. Drug Testing for DOE Positions | Department of Energy

    Energy Savers [EERE]

    Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact Sheet on the Consequences of a Positive Drug Test View Frequently Asked Questions Ask a Question - Please submit questions related only to drug testing for DOE positions. Contact Dawn Cheek

  7. Waste Feed Delivery Environmental Permits and Approvals Plan

    SciTech Connect (OSTI)

    TOLLEFSON, K.S.

    2000-01-18

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

  8. ORISE Contract, PART I - SCHEDULE, Section F Deliveries or Performance

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    F DELIVERIES OR PERFORMANCE F.1 52.242-15 STOP-WORK ORDER (AUG 1989) - ALTERNATE I (APR 1984) ................... 3 F.2 TERM OF CONTRACT (NOV 2004) ...................................................................................... 4 F.3 PLACE OF PERFORMANCE (NOV 2004)............................................................................ 4 F.4 TRANSITION ACTIVITIES (JUL 2005) ................................................................................ 4 Section F - Page 1 of 4

  9. United Parcel Service Evaluates Hybrid Electric Delivery Vans (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2010-02-01

    This fact sheet describes how the National Renewable Energy Laboratory's Fleet Test and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans - fueled by regular diesel - and six comparable conventional diesel vans operated by the United Parcel Service.

  10. U.S. Department of Energy Office of Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Office of Electricity Delivery and Energy Reliability Visualization & Controls Program Peer Review Control Systems Security Project Summaries National SCADA Test Bed NSTB Enhancing control systems security in the energy sector Arlington, Virginia October 18, 2006 NSTB VISUALIZATION AND CONTROLS PROGRAM PEER REVIEW, SESSION B WEDNESDAY, OCTOBER 18, 2006 PROGRAM MANAGER - HANK KENCHINGTON Table of Contents SCADA/EMS Cyber Security Assessments

  11. TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Energy Savers [EERE]

    Figure 1 TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, U.S. Department of Energy FROM: Electricity Advisory Committee (EAC) Richard Cowart, Chair DATE: September 30, 2015 RE: Grid Modernization: ARRA Accomplishments and Recommendations for Moving Forward ________________________________________________________________________ 1 Background and Purpose The U.S. Department of Energy (DOE)'s smart grid portion of the American Reinvestment and

  12. Competition Advocates and Task-Order and Delivery Order Ombudsman |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration Competition Advocates and Task-Order and Delivery Order Ombudsman | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Countering Nuclear Terrorism About Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Library Bios Congressional Testimony Fact

  13. Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel ...

  14. DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Delivery Analysis and High Pressure Tanks R&D Project Review Meeting Agenda DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting Agenda DOE Hydrogen ...

  15. Lipid phase control of DNA delivery (Journal Article) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Search Results Journal Article: Lipid phase control of DNA delivery Citation Details In-Document Search Title: Lipid phase control of DNA delivery Cationic lipids ...

  16. LIFE Target Fabrication Research Plan Sept 2008

    SciTech Connect (OSTI)

    Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

    2008-11-10

    The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

  17. Project Startup: Evaluating Coca-Cola's Class 8 Hybrid-Electric Delivery Trucks (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2011-03-01

    Fact sheet describing the project startup for evaluating Coca-Cola's Class 8 hybrid-electric delivery trucks.

  18. Secretary Chu's Remarks at the World Renewable Energy Forum Press Availability- As Prepared for Delivery

    Broader source: Energy.gov [DOE]

    Secretary Chu's remarks, as prepared for delivery, at a press availability at the World Renewable Energy Forum in Denver, Colorado.

  19. Overview of FreedomCAR & Fuels Partnership/DOE Delivery Program |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy FreedomCAR & Fuels Partnership/DOE Delivery Program Overview of FreedomCAR & Fuels Partnership/DOE Delivery Program Presentation on FreedomCAR & Fuells Partnership for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory PDF icon 02_parks_dtt.pdf More Documents & Publications Delivery Tech Team DOE Hydrogen Program Overview President's Hydrogen Fuel Initiative

  20. H2A Delivery: Forecourt Compression & Storage Optimization (Part II) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Delivery: Forecourt Compression & Storage Optimization (Part II) H2A Delivery: Forecourt Compression & Storage Optimization (Part II) Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 PDF icon deliv_analysis_hooks.pdf More Documents & Publications H2A Delivery: GH2 and LH2 Forecourt Land Areas Forecourt Storage and Compression Options

  1. DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Meeting Agenda | Department of Energy Delivery Analysis and High Pressure Tanks R&D Project Review Meeting Agenda DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting Agenda DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting Agenda, held February 8-9, 2005 by Argonne National Laboratory PDF icon pipeline_agenda.pdf More Documents & Publications Meeting Agenda Joint Meeting on Hydrogen Delivery Modeling and Analysis

  2. FY 2012 Budget Control Table for the Office of Electricity Delivery and

    Energy Savers [EERE]

    Energy Reliability | Department of Energy Control Table for the Office of Electricity Delivery and Energy Reliability FY 2012 Budget Control Table for the Office of Electricity Delivery and Energy Reliability Table showing the FY 2010 Current Appropriation, the FY 2011 Continuing Resolution and the FY 2012 Congressional Request for the Office of Electricity Delivery and Energy Reliability PDF icon FY 2012 Budget Control Table for the Office of Electricity Delivery and Energy Reliability More

  3. FY 2014 Budget Request for the Office of Electricity Delivery and Energy

    Office of Environmental Management (EM)

    Reliability | Department of Energy Budget Request for the Office of Electricity Delivery and Energy Reliability FY 2014 Budget Request for the Office of Electricity Delivery and Energy Reliability Table showing the FY 2012 Current Appropriation, the FY 2013 Annualized Continuing Resolution, and the FY 2014 Congressional Request for the Office of Electricity Delivery and Energy Reliability. PDF icon FY 14 Budget Request for the Office of Electricity Delivery and Energy Reliability More

  4. Effect of Intrafraction Prostate Motion on Proton Pencil Beam Scanning Delivery: A Quantitative Assessment

    SciTech Connect (OSTI)

    Tang, Shikui; Deville, Curtiland; McDonough, James; Tochner, Zelig; Wang, Ken Kang-Hsin; Vapiwala, Neha; Both, Stefan

    2013-10-01

    Purpose: To assess the dosimetric impact caused by the interplay between intrafraction prostate motion and the intermittent delivery of proton pencil beam scanning (PBS). Methods and Materials: A cohort of 10 prostate patients was treated with PBS using a bilateral single-field uniform dose (SFUD) modality. Bilateral intensity-modulated proton therapy (IMPT) plans were generated for comparison. Because beam-on time in PBS was intermittent, the actual beam-on time was determined from treatment logs. Prostate motion was generalized according to real-time Calypso tracking data from our previously reported prospective photon trial. We investigated potential dose deviations by considering the interplay effect resulting from the worst-case scenario motion and the PBS delivery sequence. Results: For both bilateral-field SFUD and IMPT plans, clinical target volume (CTV) D{sub 99}% coverage was degraded <2% owing to prostate intrafraction motion when averaged over the course of treatment, but was >10% for the worst fraction. The standard deviation of CTV D{sub 99}% distribution was approximately 1.2%. The CTV coverage of individual fields in SFUD plans degraded as time elapsed after the initial alignment, owing to prostate drift. Intensity-modulated proton therapy and SFUD demonstrated comparable results when bilateral opposed fields were used. Single-field SFUD plans that were repainted twice, which could reduce half of the treatment time, resulted in similar CTV coverage as bilateral-field plans. Conclusions: Intrafraction prostate motion affects the actual delivered dose to CTV; however, when averaged over the course of treatment, CTV D{sub 99}% coverage degraded only approximately 2% even for the worst-case scenario. The IMPT plan results are comparable to those of the SFUD plan, and similar coverage can be achieved if treated by SFUD 1 lateral field per day when rescanning the field twice to shorten the treatment time and mitigate intrafraction motion.

  5. Cascaded target normal sheath acceleration

    SciTech Connect (OSTI)

    Wang, W. P.; Shen, B. F.; Zhang, X. M.; Wang, X. F.; Xu, J. C.; Zhao, X. Y.; Yu, Y. H.; Yi, L. Q.; Shi, Y.; Zhang, L. G.; Xu, T. J.; Xu, Z. Z.

    2013-11-15

    A cascaded target normal sheath acceleration (TNSA) scheme is proposed to simultaneously increase energy and improve energy spread of a laser-produced mono-energetic proton beam. An optimum condition that uses the maximum sheath field to accelerate the center of the proton beam is theoretically found and verified by two-dimensional particle-in-cell simulations. An initial 10 MeV proton beam is accelerated to 21 MeV with energy spread decreased from 5% to 2% under the optimum condition during the process of the cascaded TNSA. The scheme opens a way to scale proton energy lineally with laser energy.

  6. FOAM: NOVEL DELIVERY TECHNOLOGY FOR REMEDIATION OF VADOSE ZONE ENVIRONMENTS

    SciTech Connect (OSTI)

    Jansik, Danielle P.; Wellman, Dawn M.; Mattigod, Shas V.; Zhong, Lirong; Wu, Yuxin; Foote, Martin; Zhang, Z. F.; Hubbard, Susan

    2011-07-05

    Deep vadose zone environments can be a primary source and pathway for contaminant migration to groundwater. These environments present unique characterization and remediation challenges that necessitate scrutiny and research. The thickness, depth, and intricacies of the deep vadose zone, combined with a lack of understanding of the key subsurface processes (e.g., biogeochemical and hydrologic) affecting contaminant migration, make it difficult to create validated conceptual and predictive models of subsurface flow dynamics and contaminant behavior across multiple scales. These factors also make it difficult to design and deploy sustainable remedial approaches and monitor long-term contaminant behavior after remedial actions. Functionally, the methods for addressing contamination must remove and/or reduce transport of contaminants. This problem is particularly challenging in the arid western United States where the vadose zone is hundreds of feet thick, rendering transitional excavation methods exceedingly costly and ineffective. Delivery of remedial amendments is one of the most challenging and critical aspects for all remedy-based approaches. The conventional approach for delivery is through injection of aqueous remedial solutions. However, heterogeneous deep vadose zone environments present hydrologic and geochemical challenges which limit the effectiveness. Because the flow of solution infiltration is dominantly controlled by gravity and suction, injected liquid preferentially percolates through highly permeable pathways, by-passing low-permeability zones which frequently contain the majority of contamination. Moreover, the wetting front can readily mobilize and enhance contaminant transport to the underlying aquifer prior to stabilization. Development of innovative, in-situ technologies may be the only way to meet remedial action objectives and long-term stewardship goals. Surfactants can be used to lower the liquid surface tension and create stabile foams, which readily penetrate low permeability zones. Although surfactant foams have been utilized for subsurface mobilization efforts in the oil and gas industry, so far, the concept of using foams as a delivery mechanism for transporting remedial amendments into deep vadose zone environments to stabilize metal and long-lived radionuclide contaminants has not been explored. Foam flow can be directed by pressure gradients, rather than being dominated by gravity; and, foam delivery mechanisms limit the volume of water (< 5% vol.) required for remedy delivery and emplacement, thus mitigating contaminant mobilization. We will present the results of a numerical modeling and integrated laboratory- / intermediate-scale investigation to simulate, develop, demonstrate, and monitor (i.e. advanced geophysical techniques and advanced predictive biomarkers) foam-based delivery of remedial amendments to remediate metals and radionuclides in vadose zone environments.

  7. Target GmbH | Open Energy Information

    Open Energy Info (EERE)

    navigation, search Name: Target GmbH Place: Germany Sector: Efficiency, Solar Product: German company with interests in solar and energy efficiency. References: Target GmbH1 This...

  8. Targets and processes for fabricating same

    DOE Patents [OSTI]

    Cowan, Thomas (Dresden, DE); Malekos, Steven (Reno, NV); Korgan, Grant (Reno, NV); Adams, Jesse (Reno, NV); Sentoku, Yasuhiko (Reno, NV); Le Galloudec, Nathalie (Reno, NV); Fuchs, Julien (Paris, FR)

    2012-07-24

    In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

  9. Novel targeted therapy for stomach cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Novel targeted therapy for stomach cancer Novel targeted therapy for stomach cancer This finding has the potential to save thousand of lives a year by delivering a more effective,...

  10. Spontaneous Liver Rupture After Treatment With Drug-Eluting Beads...

    Office of Scientific and Technical Information (OSTI)

    ANTIBIOTICS; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC DRUGS; BODY; CARCINOMAS; DIGESTIVE SYSTEM; DISEASES; DRUGS; FAILURES; GLANDS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; ...

  11. Minnesota Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Minnesota Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.49 2.52 2.65 2.72 2.59 2.44 2.52 2000's 2.60 2.62 2.77 2.72 2.73 2.66 2.68 2.73 2.85 2.79 2010's 2.57 2.66 2.63 2.86 2.88 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  12. Mississippi Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Mississippi Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.57 0.56 0.56 0.58 0.55 0.55 0.52 2000's 0.54 0.59 0.54 0.52 0.50 0.51 0.49 0.47 0.49 0.49 2010's 0.57 0.52 0.47 0.51 0.56 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  13. Missouri Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Missouri Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.71 2.53 2.58 2.62 2.56 2.45 2.37 2000's 2.31 2.44 2.34 2.26 2.25 2.21 2.18 2.15 2.33 2.22 2010's 2.25 2.18 2.00 2.17 2.27 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  14. Montana Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Montana Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.41 0.39 0.41 0.42 0.42 0.42 0.42 2000's 0.40 0.42 0.44 0.40 0.41 0.41 0.45 0.42 0.44 0.46 2010's 0.44 0.46 0.46 0.42 0.42 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  15. Nebraska Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Nebraska Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.97 0.92 0.93 0.94 0.95 0.90 0.86 2000's 0.85 0.98 0.90 0.83 0.79 0.79 0.82 0.82 0.87 0.84 2010's 0.84 0.84 0.75 0.84 0.83 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  16. Nevada Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Nevada Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.42 0.44 0.43 0.43 0.51 0.66 0.61 2000's 0.60 0.68 0.65 0.65 0.75 0.75 0.87 0.81 0.79 0.81 2010's 0.82 0.86 0.89 0.85 0.69 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  17. New Hampshire Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) New Hampshire Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.13 0.14 0.13 0.13 0.14 0.14 0.14 2000's 0.15 0.14 0.14 0.16 0.15 0.16 0.15 0.16 0.14 0.15 2010's 0.14 0.15 0.15 0.15 0.15 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  18. New Jersey Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) New Jersey Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.95 4.47 4.01 4.25 4.35 4.35 4.43 2000's 4.40 4.51 4.29 4.80 4.77 4.79 4.51 4.83 4.51 4.73 2010's 4.58 4.53 4.61 4.62 4.87 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  19. New Mexico Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) New Mexico Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.64 0.64 0.59 0.64 0.74 0.79 0.75 2000's 0.72 0.73 0.69 0.62 0.71 0.69 0.70 0.71 0.69 0.68 2010's 0.74 0.73 0.78 0.74 0.64 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  20. Ohio Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Ohio Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 7.14 7.08 7.38 7.15 7.11 6.56 6.73 2000's 6.88 6.47 6.57 6.75 6.59 6.69 6.23 6.34 6.27 6.12 2010's 5.93 6.07 6.05 6.07 6.30 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring

  1. Oklahoma Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Oklahoma Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.58 1.43 1.42 1.46 1.44 1.47 1.30 2000's 1.34 1.35 1.37 1.29 1.22 1.23 1.21 1.27 1.35 1.30 2010's 1.37 1.30 1.18 1.35 1.36 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  2. Oregon Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Oregon Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.60 0.60 0.58 0.63 0.65 0.76 0.82 2000's 0.78 0.80 0.79 0.73 0.79 0.82 0.94 0.91 0.92 0.94 2010's 0.85 0.99 1.04 0.94 0.81 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  3. Pennsylvania Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Pennsylvania Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 5.43 5.54 5.40 5.32 5.27 4.82 5.11 2000's 5.26 5.01 4.89 5.22 5.09 5.08 4.71 4.90 4.69 4.76 2010's 4.68 4.66 4.76 4.73 5.01 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  4. Colorado Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Colorado Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.14 2.05 2.15 2.12 2.32 2.45 2.37 2000's 2.33 2.59 2.64 2.45 2.48 2.57 2.73 2.77 2.74 2.70 2010's 2.74 2.76 2.79 2.76 2.60 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  5. Delaware Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Delaware Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.17 0.18 0.18 0.19 0.18 0.17 0.19 2000's 0.19 0.19 0.20 0.21 0.21 0.21 0.21 0.21 0.20 0.21 2010's 0.21 0.21 0.21 0.21 0.22 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  6. District of Columbia Natural Gas % of Total Residential Deliveries

    Gasoline and Diesel Fuel Update (EIA)

    (Percent) % of Total Residential Deliveries (Percent) District of Columbia Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.34 0.33 0.32 0.33 0.32 0.29 0.30 2000's 0.31 0.27 0.29 0.30 0.29 0.29 0.26 0.28 0.27 0.28 2010's 0.28 0.26 0.27 0.27 0.28 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next

  7. Florida Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Florida Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.28 0.29 0.30 0.31 0.26 0.31 0.29 2000's 0.30 0.33 0.31 0.31 0.33 0.33 0.36 0.32 0.32 0.32 2010's 0.39 0.35 0.35 0.31 0.33 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  8. Georgia Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Georgia Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.33 2.18 2.36 2.42 2.30 2.38 2.09 2000's 2.82 2.51 2.59 2.56 2.60 2.58 2.52 2.37 2.44 2.48 2010's 2.90 2.40 2.35 2.48 2.64 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  9. Hawaii Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Hawaii Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.01 0.01 0.01 0.01 0.01 0.01 0.01 2000's 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 2010's 0.01 0.01 0.01 0.01 0.01 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  10. Idaho Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Idaho Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.25 0.25 0.27 0.29 0.31 0.35 0.38 2000's 0.38 0.40 0.42 0.37 0.42 0.45 0.51 0.50 0.56 0.53 2010's 0.50 0.57 0.58 0.56 0.48 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring

  11. Illinois Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Illinois Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 9.99 9.77 10.33 10.28 9.98 9.07 9.42 2000's 9.35 8.95 9.40 9.32 9.11 9.07 9.12 9.17 9.52 9.21 2010's 8.71 8.87 8.70 9.24 9.42 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  12. Indiana Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Indiana Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.31 3.25 3.32 3.43 3.39 3.10 3.21 2000's 3.23 3.09 3.21 3.10 3.05 3.08 2.92 3.02 3.12 2.92 2010's 2.89 2.80 2.78 2.95 3.08 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  13. Iowa Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Iowa Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.68 1.61 1.70 1.68 1.64 1.52 1.51 2000's 1.48 1.49 1.46 1.46 1.40 1.39 1.42 1.43 1.54 1.47 2010's 1.43 1.42 1.35 1.48 1.51 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring

  14. Kansas Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Kansas Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.71 1.53 1.56 1.63 1.39 1.55 1.44 2000's 1.41 1.47 1.45 1.39 1.34 1.35 1.31 1.34 1.44 1.49 2010's 1.40 1.39 1.22 1.39 1.40 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  15. Kentucky Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Kentucky Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.35 1.29 1.36 1.34 1.33 1.23 1.25 2000's 1.29 1.19 1.21 1.22 1.16 1.16 1.08 1.09 1.12 1.08 2010's 1.14 1.08 1.04 1.11 1.13 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  16. Louisiana Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Louisiana Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.14 1.09 1.09 1.08 1.06 1.05 0.95 2000's 1.00 1.03 1.01 0.93 0.88 0.85 0.77 0.79 0.76 0.76 2010's 0.95 0.84 0.77 0.79 0.87 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  17. Maine Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Maine Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.02 0.02 0.02 0.02 0.02 0.02 0.02 2000's 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.03 2010's 0.03 0.03 0.04 0.04 0.05 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring

  18. Maryland Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Maryland Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.55 1.58 1.58 1.63 1.56 1.51 1.58 2000's 1.68 1.48 1.64 1.79 1.77 1.78 1.63 1.77 1.66 1.73 2010's 1.75 1.65 1.70 1.70 1.78 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  19. Massachusetts Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Massachusetts Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.45 2.47 2.18 2.18 2.25 2.26 2.24 2000's 2.28 2.24 2.24 2.48 2.32 2.46 2.38 2.44 2.71 2.78 2010's 2.63 2.74 2.78 2.39 2.49 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  20. Michigan Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Michigan Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 7.46 7.52 7.84 7.62 7.62 7.07 7.42 2000's 7.36 7.20 7.52 7.59 7.44 7.43 7.23 6.95 6.99 6.84 2010's 6.36 6.75 6.67 6.82 6.97 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  1. Alaska Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Alaska Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.28 0.31 0.31 0.31 0.30 0.35 0.37 2000's 0.32 0.35 0.33 0.33 0.37 0.37 0.47 0.42 0.44 0.42 2010's 0.39 0.43 0.52 0.39 0.35 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  2. Arizona Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Arizona Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.57 0.61 0.55 0.53 0.62 0.80 0.70 2000's 0.70 0.76 0.72 0.71 0.78 0.74 0.83 0.81 0.79 0.73 2010's 0.79 0.82 0.84 0.81 0.64 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  3. Arkansas Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Arkansas Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.92 0.86 0.85 0.88 0.85 0.85 0.77 2000's 0.85 0.78 0.80 0.75 0.71 0.70 0.72 0.69 0.73 0.70 2010's 0.76 0.72 0.63 0.71 0.75 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  4. California Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) California Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 10.11 10.75 9.85 9.03 9.61 12.17 12.03 2000's 10.34 10.75 10.45 9.80 10.52 10.02 11.26 10.43 10.00 10.06 2010's 10.35 10.87 11.52 9.84 7.81 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release

  5. Rhode Island Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Rhode Island Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.40 0.36 0.36 0.36 0.36 0.36 0.35 2000's 0.37 0.38 0.36 0.40 0.40 0.40 0.39 0.37 0.36 0.37 2010's 0.35 0.36 0.38 0.37 0.39 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  6. South Carolina Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) South Carolina Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.49 0.48 0.52 0.56 0.52 0.56 0.54 2000's 0.58 0.58 0.56 0.57 0.60 0.59 0.57 0.53 0.55 0.57 2010's 0.68 0.57 0.55 0.58 0.63 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  7. South Dakota Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) South Dakota Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.25 0.25 0.26 0.27 0.27 0.26 0.25 2000's 0.25 0.26 0.26 0.26 0.25 0.25 0.26 0.26 0.28 0.28 2010's 0.27 0.27 0.26 0.28 0.28 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  8. Tennessee Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Tennessee Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.19 1.18 1.24 1.34 1.29 1.31 1.28 2000's 1.37 1.43 1.42 1.37 1.34 1.37 1.40 1.29 1.41 1.38 2010's 1.55 1.43 1.30 1.45 1.54 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  9. Alabama Natural Gas % of Total Electric Utility Deliveries (Percent)

    U.S. Energy Information Administration (EIA) Indexed Site

    Electric Utility Deliveries (Percent) Alabama Natural Gas % of Total Electric Utility Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.17 0.13 0.23 0.23 0.29 0.60 0.53 2000's 0.81 1.29 1.98 1.68 2.14 1.79 2.34 2.57 2.46 3.30 2010's 3.81 4.53 4.40 4.08 4.23 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  10. Alabama Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) Indexed Site

    Residential Deliveries (Percent) Alabama Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.04 1.03 1.02 1.08 0.97 1.03 0.90 2000's 0.95 1.03 0.95 0.92 0.90 0.87 0.87 0.75 0.77 0.75 2010's 0.88 0.78 0.66 0.72 0.77 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring Pages:

  11. Alabama Natural Gas % of Total Vehicle Fuel Deliveries (Percent)

    U.S. Energy Information Administration (EIA) Indexed Site

    Vehicle Fuel Deliveries (Percent) Alabama Natural Gas % of Total Vehicle Fuel Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.44 0.20 0.15 0.08 0.71 0.57 0.57 2000's 0.57 0.52 0.52 0.52 0.52 0.67 0.47 0.36 0.32 0.29 2010's 0.37 0.64 0.64 0.63 0.63 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring Pages:

  12. Alabama Natural Gas Percentage Total Commercial Deliveries (Percent)

    U.S. Energy Information Administration (EIA) Indexed Site

    Commercial Deliveries (Percent) Alabama Natural Gas Percentage Total Commercial Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.90 0.88 0.87 0.92 1.01 0.86 0.91 2000's 0.80 0.87 0.80 0.80 0.85 0.84 0.86 0.78 0.80 0.78 2010's 0.87 0.80 0.74 0.77 0.79 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring

  13. Alabama Natural Gas Percentage Total Industrial Deliveries (Percent)

    U.S. Energy Information Administration (EIA) Indexed Site

    Industrial Deliveries (Percent) Alabama Natural Gas Percentage Total Industrial Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.28 2.23 2.38 2.27 2.36 2.39 2.53 2000's 2.46 2.11 2.13 2.22 2.25 2.29 2.30 2.26 2.13 2.13 2010's 2.12 2.19 2.38 2.42 2.46 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring

  14. Alaska Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Exports (No Intransit Deliveries) (Million Cubic Feet) Alaska Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 49,861 52,857 52,840 52,883 50,172 48,599 51,573 51,424 1990's 52,546 54,005 52,532 55,989 62,682 65,283 67,648 62,187 65,951 63,607 2000's 65,610 65,753 63,439 65,698 62,099 65,124 60,765 48,396 39,164 30,536 2010's 30,100 16,398 9,342 0 13,310 - = No Data Reported; -- = Not

  15. Arizona Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Exports (No Intransit Deliveries) (Million Cubic Feet) Arizona Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 1,694 1,646 1,757 1,813 1,525 1,757 1,905 1,469 1990's 1,676 1,597 2,565 3,253 2,459 42 3,405 3,901 4,166 4,279 2000's 9,099 8,452 11,257 10,840 7,544 7,376 15,720 16,207 46,581 44,152 2010's 44,693 45,086 46,385 54,139 64,692 - = No Data Reported; -- = Not Applicable; NA = Not

  16. Michigan Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Exports (No Intransit Deliveries) (Million Cubic Feet) Michigan Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 0 0 0 0 9,113 3,257 17,900 38,361 1990's 17,284 14,751 67,763 44,413 49,470 26,948 50,363 56,447 39,683 36,998 2000's 70,980 161,588 171,515 259,597 368,947 337,818 317,291 455,216 531,333 673,318 2010's 721,075 876,267 872,620 684,510 554,675 - = No Data Reported; -- = Not

  17. Montana Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Exports (No Intransit Deliveries) (Million Cubic Feet) Montana Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 162 136 127 178 90 40 39 82 1990's 75 41 14 106 3,087 1,510 2000's 1,606 2,978 16,036 8,889 23,379 19,159 21,245 20,420 16,399 12,504 2010's 9,437 6,826 4,332 2,353 891 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company

  18. U.S. Natural Gas Interstate Deliveries (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Deliveries (Million Cubic Feet) U.S. Natural Gas Interstate Deliveries (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 50,697,415 1990's 51,022,894 49,708,414 52,574,795 52,674,053 57,969,941 61,167,051 62,953,877 61,199,549 55,139,674 57,326,720 2000's 58,570,289 65,774,849 63,389,468 65,793,961 64,423,388 63,027,775 61,863,323 66,858,134 70,305,954 72,022,602 2010's 74,778,078 74,661,629 70,195,570 64,110,541 62,914,469 - = No Data

  19. Washington Natural Gas Exports (No Intransit Deliveries) (Million Cubic

    U.S. Energy Information Administration (EIA) Indexed Site

    Feet) Exports (No Intransit Deliveries) (Million Cubic Feet) Washington Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 0 0 0 0 0 1990's 208 0 2000's 0 1,529 1,477 33 15 1,304 2,529 6,560 10,603 12,530 2010's 7,769 9,768 6,016 10,409 3,547 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next

  20. Utah Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Utah Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.05 1.01 1.01 1.04 1.17 1.26 1.17 2000's 1.11 1.15 1.21 1.08 1.24 1.20 1.37 1.28 1.35 1.36 2010's 1.38 1.49 1.44 1.44 1.23 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016 Referring

  1. Vermont Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Vermont Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.05 0.05 0.05 0.05 0.05 0.05 0.05 2000's 0.06 0.06 0.06 0.06 0.06 0.06 0.07 0.07 0.06 0.07 2010's 0.06 0.07 0.07 0.07 0.08 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  2. Virginia Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Virginia Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.32 1.34 1.42 1.45 1.48 1.40 1.46 2000's 1.60 1.47 1.54 1.68 1.70 1.77 1.64 1.71 1.63 1.77 2010's 1.84 1.68 1.70 1.75 1.82 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  3. Washington Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Washington Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.08 1.10 1.09 1.20 1.24 1.37 1.52 2000's 1.44 1.77 1.50 1.40 1.46 1.53 1.73 1.70 1.73 1.76 2010's 1.58 1.81 1.93 1.70 1.55 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  4. Wisconsin Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Wisconsin Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.63 2.64 2.80 2.82 2.73 2.57 2.70 2000's 2.70 2.63 2.81 2.80 2.78 2.72 2.76 2.78 2.87 2.79 2010's 2.58 2.75 2.71 2.92 2.96 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  5. Wyoming Natural Gas % of Total Residential Deliveries (Percent)

    Gasoline and Diesel Fuel Update (EIA)

    % of Total Residential Deliveries (Percent) Wyoming Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.26 0.24 0.25 0.26 0.26 0.28 0.26 2000's 0.24 0.23 0.27 0.24 0.25 0.24 0.27 0.26 0.27 0.26 2010's 0.27 0.28 0.28 0.28 0.26 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 2/29/2016 Next Release Date: 3/31/2016

  6. California Natural Gas Exports (No Intransit Deliveries) (Million Cubic

    U.S. Energy Information Administration (EIA) Indexed Site

    Feet) Exports (No Intransit Deliveries) (Million Cubic Feet) California Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 0 0 0 0 0 1990's 308 2,067 3,761 2000's 13,152 23,320 35,305 53,720 80,019 89,987 101,101 96,757 109,127 101,422 2010's 43,278 94,433 110,656 107,273 120,359 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual

  7. Louisiana Natural Gas Deliveries to Electric Power Consumers (Million Cubic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) Louisiana Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 14,443 11,997 14,142 21,746 20,692 21,707 32,832 38,346 25,901 19,391 10,270 11,549 2002 20,006 19,396 24,864 27,662 28,456 34,039 40,542 41,790 32,420 23,674 16,204 14,750 2003 19,955 15,360 14,860 18,716 20,153 22,791 26,663 28,685 20,590 18,689 15,461 14,484 2004 17,038 17,344 19,280

  8. Kansas Natural Gas Deliveries to Electric Power Consumers (Million Cubic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) Kansas Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 754 698 1,011 922 1,178 1,864 7,234 5,034 1,476 1,137 1,096 863 2002 883 776 1,531 957 755 2,829 5,491 4,045 1,984 683 781 672 2003 801 700 976 716 791 1,107 2,804 3,758 738 533 775 789 2004 406 361 533 787 636 1,212 902 1,827 2,267 662 440 442 2005 707 621 682 865 1,011 1,814 2,632 2,083

  9. Missouri Natural Gas Deliveries to Electric Power Consumers (Million Cubic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) Missouri Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 485 658 1,414 2,191 2,151 3,045 6,959 7,272 2,925 2,000 1,841 1,864 2002 1,904 1,622 2,117 2,584 1,530 3,437 6,710 5,248 3,221 543 576 418 2003 1,631 669 810 2,434 1,315 1,287 5,317 6,247 809 112 476 671 2004 1,676 1,666 936 1,570 3,470 2,644 3,916 2,985 3,072 1,133 592 914 2005 1,600 1,015

  10. Montana Natural Gas Deliveries to Electric Power Consumers (Million Cubic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) Montana Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 2 1 5 2 9 20 62 48 5 3 2 2 2002 2 1 1 1 12 35 29 20 10 1 1 4 2003 7 20 21 2 11 37 26 63 11 15 11 34 2004 16 16 16 16 16 16 16 16 16 16 16 16 2005 13 11 14 14 13 24 32 32 19 14 12 15 2006 7 8 12 8 11 68 114 101 59 68 44 44 2007 73 60 49 58 83 99 119 118 102 87 73 79 2008 65 38 26 43 46 48 27

  11. Maryland Natural Gas Deliveries to Electric Power Consumers (Million Cubic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) Maryland Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 369 496 1,321 862 1,062 1,330 2,607 4,377 2,319 1,555 525 698 2002 573 490 607 1,253 843 1,972 4,207 6,572 2,957 1,098 769 932 2003 811 691 439 732 630 1,740 1,851 1,639 680 548 609 624 2004 691 523 490 770 1,891 1,669 1,400 1,334 1,184 579 718 796 2005 813 673 731 693 827 2,767 3,162 4,809

  12. Massachusetts Natural Gas Deliveries to Electric Power Consumers (Million

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cubic Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) Massachusetts Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 5,015 4,464 6,921 4,553 6,846 8,389 8,716 11,433 11,686 10,562 8,428 9,281 2002 10,482 6,633 9,702 6,925 10,459 10,846 13,254 14,505 13,386 11,693 9,628 11,339 2003 8,619 8,909 9,871 13,235 11,504 15,307 19,958 19,177 16,909 18,511 14,243 13,008 2004 11,387 10,037 13,270 17,193

  13. Cobalt-60 tomotherapy: Clinical treatment planning and phantom dose delivery studies

    SciTech Connect (OSTI)

    Dhanesar, Sandeep; Darko, Johnson; Joshi, Chandra P.; Kerr, Andrew; John Schreiner, L.

    2013-08-15

    Purpose: Investigations have shown that a Cobalt-60 (Co-60) radioactive source has the potential to play a role in intensity modulated radiation therapy (IMRT). In this paper, Co-60 tomotherapy's conformal dose delivery potential is evaluated by delivering conformal dose plans on a cylindrical homogeneous phantom containing clinical structures similar to those found in a typical head and neck (H and N) cancer. Also, the clinical potential of Co-60 tomotherapy is investigated by generating 2D clinical treatment plans for H and N and prostate anatomical regions. These plans are compared with the 6 MV based treatment plans for modalities such as linear accelerator-based tomotherapy and broad beam IMRT, and 15 MV based 3D conformal radiation therapy (3DCRT).Methods: For experimental validation studies, clinical and nonclinical conformal dose patterns were delivered on circular, homogeneous phantoms containing GafChromic film. For clinical planning study, dose calculations were performed with the EGSnrc Monte Carlo program, where a Theratronics 780C Co-60 unit and a 6 MV linear accelerator were modeled with a MIMiC binary multileaf collimator. An inhouse inverse treatment planning system was used to optimize tomotherapy plans using the same optimization parameters for both Co-60 and 6 MV beams. The IMRT and 3DCRT plans for the clinical cases were generated entirely in the Eclipse treatment planning system based on inhouse IMRT and 3DCRT site specific protocols.Results: The doses delivered to the homogeneous phantoms agreed with the calculations, indicating that it is possible to deliver highly conformal doses with the Co-60 unit. The dose distributions for Co-60 tomotherapy clinical plans for both clinical cases were similar to those obtained with 6 MV based tomotherapy and IMRT, and much more conformal compared to 3DCRT plans. The dose area histograms showed that the Co-60 plans achieve the dose objectives for the targets and organs at risk.Conclusions: These results confirm that Co-60 tomotherapy is capable of providing state-of-the-art conformal dose delivery and could be used for the treatment of targets in both small and larger separation anatomical regions.

  14. H2A Delivery Scenario Model and Analyses | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Scenario Model and Analyses H2A Delivery Scenario Model and Analyses Presentation on H2A Delivery Scenario Model and Analysis for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory PDF icon 06_mintz_gillette_h2a.pdf More Documents & Publications H2A Delivery Models and Results H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report Hydrogen

  15. Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Florist Natural Gas Delivery Vans Support McShan Florist to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Twitter Bookmark Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Google Bookmark Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Delicious Rank Alternative

  16. National Targets Table | Department of Energy

    Energy Savers [EERE]

    National Targets Table National Targets Table PDF icon National Targets Table More Documents & Publications Commercial Building Energy Asset Rating Workshop Fossil Fuel-Generated Energy Consumption Reduction for New Federal Buildings and Major Renovations of Federal Buildings OIRA Comparison Document Fossil Fuel-Generated Energy Consumption Reduction for New Federal Buildings and Major Renovations of Federal Buildings

  17. Mr. Lamont Jackson Office of Electricity Delivery and Energy Reliability

    Broader source: Energy.gov (indexed) [DOE]

    8, 2012 Mr. Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 Submitted via email to: Lamont.Jackson@hq.doe.gov Re: Department of Energy - Rapid Response Team for Transmission Request for Information, RRTT-IR-01, 77 Fed. Reg. 11517 (Feb. 27, 2012) Dear Mr. Jackson: Southern California Edison Company submits these comments in response to the Department of Energy's Request for Information

  18. Lamont Jackson Office of Electricity Delivery and Energy Reliability

    Broader source: Energy.gov (indexed) [DOE]

    March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585 Via email to: Lamont.Jackson@hq.doe.gov Re: Comments on Questions Related to Permitting of Transmission Lines, 77 Fed. Reg. 11517 (Feb. 27, 2012) Dear Mr. Jackson: Thank you for the opportunity to submit comments on questions related to the permitting of transmission lines. We, the undersigned conservation organizations,

  19. Feasibility Study: Ductless Hydronic Distribution Systems with Fan Coil Delivery

    SciTech Connect (OSTI)

    Springer, D.; Dakin, B.; Backman, C.

    2012-07-01

    The primary objectives of this study are to estimate potential energy savings relative to conventional ducted air distribution, and to identify equipment requirements, costs, and barriers with a focus on ductless hydronic delivery systems that utilize water-to-air terminal units in each zone. Results indicate that annual heating and cooling energy use can be reduced by up to 27% assuming replacement of the conventional 13 SEER heat pump and coil with a similarly rated air-to-water heat pump.

  20. Gasoline Hybrid Electric Delivery Vehicles Reduce Tailpipe Emissions While

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Maintaining Fuel Economy - News Releases | NREL Gasoline Hybrid Electric Delivery Vehicles Reduce Tailpipe Emissions While Maintaining Fuel Economy February 23, 2011 The U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) recently completed a yearlong technology evaluation of gasoline hybrid electric (gHEV) trucks compared with conventional diesel vehicles. A report released this week details NREL's efforts to determine the impact of hybridization on performance,

  1. Attn: David Meyer Office of Electricity Delivery and Energy Reliability

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    P a g e October 20, 2014 Attn: David Meyer Office of Electricity Delivery and Energy Reliability U.S. Department of Energy; 1000 Independence Avenue SW Washington, DC 20585. RE: Comments on Draft National Electric Transmission Congestion Study Dear Mr. Meyer, On behalf of the American Wind Energy Association ("AWEA"), 1 we are submitting comments in response to the draft National Electric Transmission Congestion Study published August 19, 2014 (Draft NIETC Study). For the reasons set

  2. Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    SPR Oil to Marathon Petroleum Company | Department of Energy SPR Oil to Marathon Petroleum Company Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of SPR Oil to Marathon Petroleum Company September 8, 2008 - 3:20pm Addthis WASHINGTON, DC - Today, September 8, 2008, the U.S. Department of Energy will deliver 250,000 barrels of oil from the Strategic Petroleum Reserve to Marathon Petroleum Company's Midwest refineries along the Capline pipeline system. The oil was

  3. Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Strategic Petroleum Reserve Oil | Department of Energy Strategic Petroleum Reserve Oil Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of Strategic Petroleum Reserve Oil September 14, 2008 - 3:43pm Addthis WASHINGTON - The U.S. Department of Energy has agreed to deliver 200,000 barrels of emergency exchange oil from the Strategic Petroleum Reserve to ConocoPhillips Company's Wood River refinery along the Capline pipeline system. The Department will also deliver an

  4. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Energy Reliability, Before the House Appropriations Subcommittee on Energy and Water Development, March 27, 2012 | Department of Energy Appropriations Subcommittee on Energy and Water Development, March 27, 2012 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Before the House Appropriations Subcommittee on Energy and Water Development, March 27, 2012 Statement of Assistant Secretary Patricia Hoffman, Assistant Secretary for Electricity

  5. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Energy Reliability, Before the House Committee on Energy and Commerce Subcommittee on Energy and Power, May 31, 2011 | Department of Energy Before the House Committee on Energy and Commerce Subcommittee on Energy and Power, May 31, 2011 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Before the House Committee on Energy and Commerce Subcommittee on Energy and Power, May 31, 2011 Statement of Patricia Hoffman, Assistant Secretary for

  6. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Energy Reliability, Before the US House of Representatives Energy and Commerce Subcommittee on Energy and Power, May 9, 2012 | Department of Energy House of Representatives Energy and Commerce Subcommittee on Energy and Power, May 9, 2012 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, Before the US House of Representatives Energy and Commerce Subcommittee on Energy and Power, May 9, 2012 Statement of Patricia Hoffman, Assistant

  7. Mr. David Meyer Office of Electricity Delivery and Energy Reliability

    Office of Environmental Management (EM)

    Mr. David Meyer Office of Electricity Delivery and Energy Reliability U.S. Department of Energy 1000 Independence Avenue, SW Washington, DC 20585 Submitted electronically via email to: Congestionstudy.comments@hq.doe.gov Re: Department of Energy - Draft National Electric Transmission Congestion Study, 79 Fed. Reg. 49076 (Aug. 19, 2014) Dear Mr. Meyer: Duke Energy Corporation ("Duke Energy") respectfully submits these comments in response to the above-referenced Department of Energy

  8. Ms. Julie Smith Office of Electricity Delivery and Energy Reliability

    Office of Environmental Management (EM)

    5, 2013 Ms. Julie Smith Office of Electricity Delivery and Energy Reliability Mail Code OE-20 U.S. Department of Energy 1000 Independence Avenue Washington, D.C. 20585 Juliea.smith@hq.doe.gov; Christopher.lawrence@hq.doe.gov Re: DOE RFI "Improving Performance of Federal Permitting and Review of Infrastructure Projects The American people support increased production and consumption of renewable energy according to credible public opinion polls. Too often the most appropriate sites for wind,

  9. Office of Electricity Delivery and Energy Reliability | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Office of Electricity Delivery and Energy Reliability Highlights from Assistant Secretary Hoffman's Keynote at the NESC Summit 2015 Highlights from Assistant Secretary Hoffman's Keynote at the NESC Summit 2015 Read more Visualizing the impacts of sea level rise and storm surge on energy infrastructure Visualizing the impacts of sea level rise and storm surge on energy infrastructure Read more Quadrennial Technology Review Quadrennial Technology Review Report examines status of science

  10. Terahertz-based target typing.

    SciTech Connect (OSTI)

    Lyo, Sungkwun Kenneth; Wanke, Michael Clement; Reno, John Louis; Shaner, Eric Arthur; Grine, Albert D.; Barrick, Todd A.

    2008-09-01

    The purpose of this work was to create a THz component set and understanding to aid in the rapid analysis of transient events. This includes the development of fast, tunable, THz detectors, along with filter components for use with standard detectors and accompanying models to simulate detonation signatures. The signature effort was crucial in order to know the spectral range to target for detection. Our approach for frequency agile detection was to utilize plasmons in the channel of a specially designed field-effect transistor called the grating-gate detector. Grating-gate detectors exhibit narrow-linewidth, broad spectral tunability through application of a gate bias, and no angular dependence in their photoresponse. As such, if suitable sensitivity can be attained, they are viable candidates for Terahertz multi-spectral focal plane arrays.

  11. Fabrication of boron sputter targets

    DOE Patents [OSTI]

    Makowiecki, Daniel M. (Livermore, CA); McKernan, Mark A. (Livermore, CA)

    1995-01-01

    A process for fabricating high density boron sputtering targets with sufficient mechanical strength to function reliably at typical magnetron sputtering power densities and at normal process parameters. The process involves the fabrication of a high density boron monolithe by hot isostatically compacting high purity (99.9%) boron powder, machining the boron monolithe into the final dimensions, and brazing the finished boron piece to a matching boron carbide (B.sub.4 C) piece, by placing aluminum foil there between and applying pressure and heat in a vacuum. An alternative is the application of aluminum metallization to the back of the boron monolithe by vacuum deposition. Also, a titanium based vacuum braze alloy can be used in place of the aluminum foil.

  12. Synchronous identification of friendly targets

    DOE Patents [OSTI]

    Telle, John M. (126 Shady Oak Cir., Tijeras, NM 87059); Roger, Stutz A. (5 Kiowa La., Los Alamos, NM 87544)

    1998-01-01

    A synchronous communication targeting system for use in battle. The present invention includes a transceiver having a stabilizing oscillator, a synchronous amplifier and an omnidirectional receiver, all in electrical communication with each other. A remotely located beacon is attached to a blackbody radiation source and has an amplitude modulator in electrical communication with a optical source. The beacon's amplitude modulator is set so that the optical source transmits radiation frequency at approximately the same or lower amplitude than that of the blackbody radiation source to which the beacon is attached. The receiver from the transceiver is adapted to receive frequencies approximately at or below blackbody radiation signals and sends such signals to the synchronous amplifier. The synchronous amplifier then rectifies and amplifies those signals which correspond to the predetermined frequency to therefore identify whether the blackbody radiation source is friendly or not.

  13. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  14. Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium

    SciTech Connect (OSTI)

    Gajalakshmi, Palanivel; Priya, Mani Krishna; Pradeep, Thangaraj; Behera, Jyotirmaya; Muthumani, Kandasamy; Madhuwanti, Srinivasan; Saran, Uttara; Chatterjee, Suvro

    2013-06-01

    Widely used chemotherapeutic breast cancer drugs such as Tamoxifen citrate (TC), Capecitabine (CP) and Epirubicin (EP) are known to cause various cardiovascular side-effects among long term cancer survivors. Vascular modulation warrants nitric oxide (NO) signal transduction, which targets the vascular endothelium. We hypothesize that TC, CP and EP interference with the nitric oxide downstream signaling specifically, could lead to cardiovascular dysfunctions. The results demonstrate that while all three drugs attenuate NO and cyclic guanosine mono-phosphate (cGMP) production in endothelial cells, they caused elevated levels of NO in the plasma and RBC. However, PBMC and platelets did not show any significant changes under treatment. This implies that the drug effects are specific to the endothelium. Altered eNOS and phosphorylated eNOS (Ser-1177) localization patterns in endothelial cells were observed following drug treatments. Similarly, the expression of phosphorylated eNOS (Ser-1177) protein was decreased under the treatment of drugs. Altered actin polymerization was also observed following drug treatment, while addition of SpNO and 8Br-cGMP reversed this effect. Incubation with the drugs decreased endothelial cell migration whereas addition of YC-1, SC and 8Br-cGMP recovered the effect. Additionally molecular docking studies showed that all three drugs exhibited a strong binding affinity with the catalytic domain of human sGC. In conclusion, results indicate that TC, CP and EP cause endothelial dysfunctions via the NOsGCcGMP pathway and these effects could be recovered using pharmaceutical agonists of NO signaling pathway. Further, the study proposes a combination therapy of chemotherapeutic drugs and cGMP analogs, which would confer protection against chemotherapy mediated vascular dysfunctions in cancer patients. - Highlights: NO production is reduced in endothelial cells under breast cancer drug treatment. Cellular cGMP level is decreased under the treatments of breast cancer drugs. Breast cancer drugs induce vasoconstriction by interfering with NO pathway. NO donors, cGMP analogs rescue breast cancer drug induced endothelial dysfunctions.

  15. Neuroimaging for drug addiction and related behaviors

    SciTech Connect (OSTI)

    Parvaz M. A.; Parvaz, M.A.; Alia-Klein, N.; Woicik,P.A.; Volkow, N.D.; Goldstein, R.Z.

    2011-10-01

    In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle culminating in a persistent preoccupation with obtaining, consuming, and recovering from the drug. In the past two decades, imaging studies of drug addiction have demonstrated deficits in brain circuits related to reward and impulsivity. The current review focuses on studies employing positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electroencephalography (EEG) to investigate these behaviors in drug-addicted human populations. We begin with a brief account of drug addiction followed by a technical account of each of these imaging modalities. We then discuss how these techniques have uniquely contributed to a deeper understanding of addictive behaviors.

  16. SU-F-19A-08: Optimal Time Release Schedule of In-Situ Drug Release During Permanent Prostate Brachytherapy

    SciTech Connect (OSTI)

    Cormack, R; Ngwa, W; Makrigiorgos, G; Tangutoori, S; Rajiv, K; Sridhar, S

    2014-06-15

    Purpose: Permanent prostate brachytherapy spacers can be used to deliver sustained doses of radiosentitizing drug directly to the target, in order to enhance the radiation effect. Implantable nanoplatforms for chemo-radiation therapy (INCeRTs) have a maximum drug capacity and can be engineered to control the drug release schedule. The optimal schedule for sensitization during continuous low dose rate irradiation is unknown. This work studies the optimal release schedule of drug for both traditional sensitizers, and those that work by suppressing DNA repair processes. Methods: Six brachytherapy treatment plans were used to model the anatomy, implant geometry and calculate the spatial distribution of radiation dose and drug concentrations for a range of drug diffusion parameters. Three state partial differential equations (cells healthy, damaged or dead) modeled the effect of continuous radiation (radiosensitivities ?,?) and cellular repair (time tr) on a cell population. Radiosensitization was modeled as concentration dependent change in ?,? or tr which with variable duration under the constraint of fixed total drug release. Average cell kill was used to measure effectiveness. Sensitization by means of both enhanced damage and reduced repair were studied. Results: Optimal release duration is dependent on the concentration of radiosensitizer compared to the saturation concentration (csat) above which additional sensitization does not occur. Long duration drug release when enhancing ? or ? maximizes cell death when drug concentrations are generally over csat. Short term release is optimal for concentrations below saturation. Sensitization by suppressing repair has a similar though less distinct trend that is more affected by the radiation dose distribution. Conclusion: Models of sustained local radiosensitization show potential to increase the effectiveness of radiation in permanent prostate brachytherapy. INCeRTs with high drug capacity produce the greatest benefit with drug release over weeks. If in-vivo drug concentrations are not able to approach saturation concentration, durations of days is optimal. DOD 1R21CA16977501; A. David Mazzone Awards Program 2012PD164.

  17. PLUTONIUM-238 PRODUCTION TARGET DESIGN STUDIES

    SciTech Connect (OSTI)

    Hurt, Christopher J [ORNL; Wham, Robert M [ORNL; Hobbs, Randall W [ORNL; Owens, R Steven [ORNL; Chandler, David [ORNL; Freels, James D [ORNL; Maldonado, G Ivan [ORNL

    2014-01-01

    A new supply chain is planned for plutonium-238 using existing reactors at the Oak Ridge National Laboratory (ORNL) and Idaho National Laboratory (INL) and existing chemical recovery facilities at ORNL. Validation and testing activities for new irradiation target designs have been conducted in three phases over a 2 year period to provide data for scale-up to production. Target design, qualification, target fabrication, and irradiation of fully-loaded targets have been accomplished. Data from post-irradiation examination (PIE) supports safety analysis and irradiation of future target designs.

  18. MO-G-BRE-01: A Real-Time Virtual Delivery System for Photon Radiotherapy Delivery Monitoring

    SciTech Connect (OSTI)

    Shi, F; Gu, X; Jiang, S; Jia, X; Graves, Y

    2014-06-15

    Purpose: Treatment delivery monitoring is important for radiotherapy, which enables catching dosimetric error at the earliest possible opportunity. This project develops a virtual delivery system to monitor the dose delivery process of photon radiotherapy in real-time using GPU-based Monte Carlo (MC) method. Methods: The simulation process consists of 3 parallel CPU threads. A thread T1 is responsible for communication with a linac, which acquires a set of linac status parameters, e.g. gantry angles, MLC configurations, and beam MUs every 20 ms. Since linac vendors currently do not offer interface to acquire data in real time, we mimic this process by fetching information from a linac dynalog file at the set frequency. Instantaneous beam fluence map (FM) is calculated. A FM buffer is also created in T1 and the instantaneous FM is accumulated to it. This process continues, until a ready signal is received from thread T2 on which an inhouse developed MC dose engine executes on GPU. At that moment, the accumulated FM is transferred to T2 for dose calculations, and the FM buffer in T1 is cleared. Once the calculation finishes, the resulting 3D dose distribution is directed to thread T3, which displays it in three orthogonal planes overlaid on the CT image for treatment monitoring. This process continues to monitor the 3D dose distribution in real-time. Results: An IMRT and a VMAT cases used in our patient-specific QA are studied. Maximum dose differences between our system and treatment planning system are 0.98% and 1.58% for the two cases, respectively. The average time per MC calculation is 0.1sec with <2% relative uncertainty. The update frequency of ∼10Hz is considered as real time. Conclusion: By embedding a GPU-based MC code in a novel data/work flow, it is possible to achieve real-time MC dose calculations to monitor delivery process.

  19. Target Fabrication: A View from the Users

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Barnes, Cris W.; Batha, Steven H.; Christensen, Cindy R.; Cobble, James A.; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael; Swift, Damian; Workman, Jonathan

    2004-03-15

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  20. TARGET FABRICATION: A VIEW FROM THE USERS.

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Batha, Steven H.; Barnes, Cris W.; Christensen, Cindy; Cobble, James; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael S.; Swift, Damian; Workman, Jonathan

    2003-07-18

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in time to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  1. Ignition of deuterium-tritium fuel targets

    DOE Patents [OSTI]

    Musinski, D.L.; Mruzek, M.T.

    1991-08-27

    Disclosed is a method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom. 5 figures.

  2. Ignition of deuterium-trtium fuel targets

    DOE Patents [OSTI]

    Musinski, Donald L. (Saline, MI); Mruzek, Michael T. (Britton, MI)

    1991-01-01

    A method of igniting a deuterium-tritium ICF fuel target to obtain fuel burn in which the fuel target initially includes a hollow spherical shell having a frozen layer of DT material at substantially uniform thickness and cryogenic temperature around the interior surface of the shell. The target is permitted to free-fall through a target chamber having walls heated by successive target ignitions, so that the target is uniformly heated during free-fall to at least partially melt the frozen fuel layer and form a liquid single-phase layer or a mixed liquid/solid bi-phase layer of substantially uniform thickness around the interior shell surface. The falling target is then illuminated from exteriorly of the chamber while the fuel layer is at substantially uniformly single or bi-phase so as to ignite the fuel layer and release energy therefrom.

  3. Tensor Target Polarization at TRIUMF

    SciTech Connect (OSTI)

    Smith, G

    2014-10-27

    The first measurements of tensor observables in $\\pi \\vec{d}$ scattering experiments were performed in the mid-80's at TRIUMF, and later at SIN/PSI. The full suite of tensor observables accessible in $\\pi \\vec{d}$ elastic scattering were measured: $T_{20}$, $T_{21}$, and $T_{22}$. The vector analyzing power $iT_{11}$ was also measured. These results led to a better understanding of the three-body theory used to describe this reaction. %Some measurements were also made in the absorption and breakup channels. A direct measurement of the target tensor polarization was also made independent of the usual NMR techniques by exploiting the (nearly) model-independent result for the tensor analyzing power at 90$^\\circ _{cm}$ in the $\\pi \\vec{d} \\rightarrow 2p$ reaction. This method was also used to check efforts to enhance the tensor polarization by RF burning of the NMR spectrum. A brief description of the methods developed to measure and analyze these experiments is provided.

  4. Target injection methods for inertial fusion energy

    SciTech Connect (OSTI)

    Petzoldt, R.W.; Moir, R.W.

    1994-06-01

    We have studied four methods to inject IFE targets: the gas gun, electrostatic accelerator, induction accelerator, and rail gun. We recommend a gas gun for indirect drive targets because they can support a gas pressure load on one end and can slide along the gun barrel without damage. With the gas gun, the amount of gas required for each target (about 10 to 100 mg) is acceptable; for other types of targets, a sabot would be necessary. A cam and poppet valve arrangement is recommended for gas flow control. An electrostatic accelerator is attractive for use with lightweight spherical direct drive targets. Since there is no physical contact between the target and the injector, there will be no wear of either component during the injection process. An induction accelerator has an advantage of no electrical contact between the target and the injector. Physical contact is not even necessary, so the wear should be minimal. It requires a cylindrical conductive target sleeve which is a substantial added mass. A rail gun is a simpler device than an electrostatic accelerator or induction accelerator. It requires electrical contact between the target and the rails and may have a significant wear rate. The wear in a vacuum could be reduced by use of a solid lubricant such as MoS{sub 2}. The total required accuracy of target injection, tracking and beam pointing of {plus_minus}0.4 mm appears achievable but will require development and experimental verification.

  5. Functionalized mesoporous silica nanoparticles for oral delivery of budesonide

    SciTech Connect (OSTI)

    Yoncheva, K.; Popova, M.; Szegedi, A.; Mihaly, J.; Tzankov, B.; Lambov, N.; Konstantinov, S.; Tzankova, V.; Pessina, F.; Valoti, M.

    2014-03-15

    Non-functionalized and amino-functionalized mesoporous silica nanoparticle were loaded with anti-inflammatory drug budesonide and additionally post-coated with bioadhesive polymer (carbopol). TEM images showed spherical shape of the nanoparticles and slightly higher polydispersity after coating with carbopol. Nitrogen physisorption and thermogravimetic analysis revealed that more efficient loading and incorporation into the pores of nanoparticles was achieved with the amino-functionalized silica carrier. Infrared spectra indicated that the post-coating of these nanoparticles with carbopol led to the formation of bond between amino groups of the functionalized carrier and carboxyl groups of carbopol. The combination of amino-functionalization of the carrier with the post-coating of the nanoparticles sustained budesonide release. Further, an in vitro model of inflammatory bowel disease showed that the cytoprotective effect of budesonide loaded in the post-coated silica nanoparticles on damaged HT-29 cells was more pronounced compared to the cytoprotection obtained with pure budesonide. -- Graphical abstract: Silica mesoporous MCM-41 particles were amino-functionalized, loaded with budesonide and post-coated with bioadhesive polymer (carbopol) in order to achieve prolonged residence of anti-inflammatory drug in GIT. Highlights: Higher drug loading in amino-functionalized mesoporous silica. Amino-functionalization and post-coating of the nanoparticles sustained drug release. Achievement of higher cytoprotective effect with drug loaded into the nanoparticles.

  6. THERMAL OSCILLATIONS IN LIQUID HELIUM TARGETS.

    SciTech Connect (OSTI)

    WANG,L.; JIA,L.X.

    2001-07-16

    A liquid helium target for the high-energy physics was built and installed in the proton beam line at the Alternate Gradient Synchrotron of Brookhaven National Laboratory in 2001. The target flask has a liquid volume of 8.25 liters and is made of thin Mylar film. A G-M/J-T cryocooler of five-watts at 4.2K was used to produce liquid helium and refrigerate the target. A thermosyphon circuit for the target was connected to the J-T circuit by a liquid/gas separator. Because of the large heat load to the target and its long transfer lines, thermal oscillations were observed during the system tests. To eliminate the oscillation, a series of tests and analyses were carried out. This paper describes the phenomena and provides the understanding of the thermal oscillations in the target system.

  7. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1997--September 30, 1998

    SciTech Connect (OSTI)

    Gibson, J. [ed.

    1998-12-01

    During this period, General Atomics (GA) and their partner Schafer Corporation were assigned 17 formal tasks in support of the Inertial Confinement Fusion (ICF) program and its five laboratories. A portion of the effort on these tasks included providing direct ``On-site Support`` at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). They fabricated and delivered over 1,200 hohlraum mandrels and numerous other micromachined components to LLNL, LANL, and SNLA. They produced more than 1,300 glass and plastic target capsules for LLNL, LANL, SNLA, and the University of Rochester/Laboratory for Laser Energetics (UR/LLE). They also delivered nearly 2,000 various target foils and films for Naval Research Lab (NRL) and UR/LLE in FY98. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. During FY98, great progress was made by the GA/Schafer-UR/LLE-LANL team in the design, procurement, installation, and testing of the OMEGA Cryogenic Target System (OCTS) that will field cryogenic targets on OMEGA. The design phase was concluded for all components of the OCTS and all major components were procured and nearly all were fabricated. Many of the components were assembled and tested, and some have been shipped to UR/LLE. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D{sub 2} or deuterium-tritium (DT) fuel. They are part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. They also contributed cryogenic support and developed concepts for NIF cryogenic targets. This report summarizes and documents the technical progress made on these tasks.

  8. Independent Oversight Targeted Review, Sandia National Laboratories -

    Office of Environmental Management (EM)

    April 2014 | Department of Energy Targeted Review, Sandia National Laboratories - April 2014 Independent Oversight Targeted Review, Sandia National Laboratories - April 2014 April 2014 Targeted Review of the Sandia National Laboratories Federal Assurance Capability The U.S. Department of Energy (DOE) Office of Enforcement and Oversight, within the Office of Health, Safety and Security (HSS), conducted an independent review of the performance of the DOE Sandia Field Office safety oversight of

  9. Lamont Jackson Office of Electricity Delivery and Energy Reliability

    Broader source: Energy.gov (indexed) [DOE]

    March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C. 20585 OE Docket No. RRTT-IR-001 Submitted via email to: Lamont.Jackson@hq.doe.gov COMMENTS OF THE AMERICAN WIND ENERGY ASSOCIATION ON THE DEPARTMENT OF ENERGY'S REQUEST FOR INFORMATION RELATED TO THE PERMITTING OF TRANSMISSION LINES Dear Mr. Jackson, The American Wind Energy Association 1 (AWEA) appreciates the opportunity

  10. Microgel particles for the delivery of bioactive materials

    DOE Patents [OSTI]

    Frechet, Jean M.; Murthy, Niren

    2006-06-06

    Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.

  11. Microgel particles for the delivery of bioactive materials

    DOE Patents [OSTI]

    Frechet, Jean M. J. (Oakland, CA); Murthy Niren (Atlanta, GA)

    2010-03-23

    Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.

  12. THE HANFORD WASTE FEED DELIVERY OPERATIONS RESEARCH MODEL

    SciTech Connect (OSTI)

    BERRY J; GALLAHER BN

    2011-01-13

    Washington River Protection Solutions (WRPS), the Hanford tank farm contractor, is tasked with the long term planning of the cleanup mission. Cleanup plans do not explicitly reflect the mission effects associated with tank farm operating equipment failures. EnergySolutions, a subcontractor to WRPS has developed, in conjunction with WRPS tank farms staff, an Operations Research (OR) model to assess and identify areas to improve the performance of the Waste Feed Delivery Systems. This paper provides an example of how OR modeling can be used to help identify and mitigate operational risks at the Hanford tank farms.

  13. Project Plan Remote Target Fabrication Refurbishment Project

    SciTech Connect (OSTI)

    Bell, Gary L; Taylor, Robin D

    2009-08-01

    In early FY2009, the DOE Office of Science - Nuclear Physics Program reinstated a program for continued production of {sup 252}Cf and other transcurium isotopes at the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). The FY2009 major elements of the workscope are as follows: (1) Recovery and processing of seven transuranium element targets undergoing irradiation at the High Flux Isotope Reactor (HFIR) at ORNL; (2) Development of a plan to manufacture new targets for irradiation beginning in early- to mid-FY10 to supply irradiated targets for processing Campaign 75 (TRU75); and (3) Refurbishment of the target manufacturing equipment to allow new target manufacture in early FY10 The {sup 252}Cf product from processing Campaign 74 (recently processed and currently shipping to customers) is expected to supply the domestic demands for a period of approximately two years. Therefore it is essential that new targets be introduced for irradiation by the second quarter of FY10 (HFIR cycle 427) to maintain supply of {sup 252}Cf; the average irradiation period is {approx}10 HFIR cycles, requiring about 1.5 calendar years. The strategy for continued production of {sup 252}Cf depends upon repairing and refurbishing the existing pellet and target fabrication equipment for one additional target production campaign. This equipment dates from the mid-1960s to the late 1980s, and during the last target fabrication campaign in 2005- 2006, a number of component failures and operations difficulties were encountered. It is expected that following the target fabrication and acceptance testing of the targets that will supply material for processing Campaign 75 a comprehensive upgrade and replacement of the remote hot-cell equipment will be required prior to subsequent campaigns. Such a major refit could start in early FY 2011 and would take about 2 years to complete. Scope and cost estimates for the repairs described herein were developed, and authorization for the work was received in July 2009 under the Remote Target Fabrication Refurbishment Task of the Enhanced Utilization of Isotope Facilities project (Project Identification Code 2005230) funded by the American Recovery and Reinvestment Act of 2009. The goal of this project is to recover the capability to produce 4-5 curium targets for the irradiation period starting with HFIR cycle 427, currently scheduled to begin 2/17/10. Assuming success, the equipment would then be used to fabricate 6-7 additional targets to hold for the next irradiation campaign specified by the program. Specific objectives are the return to functionality of the Cubicle 3 Pellet Fabrication Line; Cubicle 2 Target Assembly equipment; and Cubicle 1 Target Inspection and Final Assembly system.

  14. Independent Oversight Targeted Review, Sandia National Laboratories...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Review, Sandia National Laboratories - November 2013 December 2013 Targeted Review of Activity-Level Implementation of Radiological Controls at Sandia National Laboratories This...

  15. Enterprise Assessments Lessons Learned From Targeted Reviews...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Lessons Learned From Targeted Reviews of Activity-Level Work Planning and Control March 2016 Office of Worker Safety and Health Assessments Office of Environment, Safety and Health ...

  16. Enterprise Assessments Targeted Review, Sandia National Laboratories...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    November 2014 Targeted Review of Work Planning and Control at the Sandia National Laboratories The U.S. Department of Energy (DOE) Office of Environment, Safety and Health ...

  17. Enterprise Assessments Lessons Learned from Targeted Reviews...

    Broader source: Energy.gov (indexed) [DOE]

    Lessons Learned from Targeted Reviews of Fire Protection Programs at Department of Energy Nuclear Facilities August 2015 Office of Nuclear Safety and Environmental Assessments...

  18. Setting Energy Savings Targets for Utilities

    SciTech Connect (OSTI)

    none,

    2011-09-01

    Helps policymakers understand how electric and natural gas utilities can achieve greater efficiency by establishing numeric energy savings targets and goals for energy efficiency programs.

  19. Enterprise Assessments Targeted Review, Argonne National Laboratory...

    Energy Savers [EERE]

    its Argonne Site Office. Independent Oversight conducted the review within the broader context of ongoing targeted assessments of radiological control programs, with an emphasis on...

  20. Enterprise Assessments Targeted Review, Lawrence Livermore National...

    Broader source: Energy.gov (indexed) [DOE]

    Targeted Review of the Safety-Class Room Ventilation Systems and Associated Final Filtration Stages, and Review of Federal Assurance Capability at the Lawrence Livermore National...

  1. Table III: Technical Targets for Catalyst Coated Membranes (CCMs...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    III: Technical Targets for Catalyst Coated Membranes (CCMs): Stationary Table III: Technical Targets for Catalyst Coated Membranes (CCMs): Stationary Technical targets for CCMs in ...

  2. Secretary Steven Chu Remarks as Prepared for Delivery to the 2011 IAEA

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    General Conference | Department of Energy Steven Chu Remarks as Prepared for Delivery to the 2011 IAEA General Conference Secretary Steven Chu Remarks as Prepared for Delivery to the 2011 IAEA General Conference 2011 IAEA General Conference Remarks as Prepared for Delivery Secretary Steven Chu Monday, September 19, 2011 Thank you, Ambassador Feruta. Congratulations on your election as President of this Conference. I also want to thank Director General Amano for his outstanding leadership. I

  3. Comments of Cisco Systems to Office of Electricity Delivery and Energy

    Energy Savers [EERE]

    Reliability | Department of Energy of Cisco Systems to Office of Electricity Delivery and Energy Reliability Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Cisco Systems provides comments in response to the RFI issued by DOE on addressing policy andlogistical challenges to smart grid implementation. PDF icon Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability More Documents & Publications NIST Activities in Support of the

  4. Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Presentation | Department of Energy Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Presentation by Patricia Hoffman of the Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request. OE's FY 2012 budget request represents a strong commitment to modernizing the grid and providing the reliable, affordable, and secure electric power needed

  5. Energy Department Announces up to $4 Million to Advance Hydrogen Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technology Development | Department of Energy Million to Advance Hydrogen Delivery Technology Development Energy Department Announces up to $4 Million to Advance Hydrogen Delivery Technology Development November 15, 2013 - 12:00am Addthis The Energy Department today announced up to $4 million in new funding to address critical challenges and barriers to advanced hydrogen delivery technology development. These investments are helping to reduce the nation's reliance on gasoline and diversify

  6. Chapter 7: Advancing Systems and Technologies to Produce Cleaner Fuels | Hydrogen Production and Delivery Technology Assessment

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7: Advancing Systems and Technologies to Produce Cleaner Fuels Technology Assessments Bioenergy Conversion Biomass Feedstocks and Logistics Gas Hydrates Research and Development Hydrogen Production and Delivery Natural Gas Delivery Infrastructure Offshore Safety and Spill Reduction Unconventional Oil and Gas ENERGY U.S. DEPARTMENT OF Quadrennial Technology Review 2015 1 Quadrennial Technology Review 2015 Hydrogen Production and Delivery Chapter 7: Technology Assessments Introduction to the

  7. Secretary Steven Chu's Remarks as Prepared for Delivery to the DOE Tribal

    Energy Savers [EERE]

    Summit | Department of Energy Secretary Steven Chu's Remarks as Prepared for Delivery to the DOE Tribal Summit Secretary Steven Chu's Remarks as Prepared for Delivery to the DOE Tribal Summit Secretary Steven Chu spoke to the DOE Tribal Summit about the creation of the Office of Indian Energy Policy and Programs. PDF icon Secretary Steven Chu's Remarks as Prepared for Delivery to the DOE Tribal Summit More Documents & Publications 2011 Tribal Summit - Secretary Chu's Prepared Remarks

  8. DOE Fuel Cell Technologies Office Record 13013: H2 Delivery Cost

    Office of Environmental Management (EM)

    Projections - 2013 | Department of Energy 3013: H2 Delivery Cost Projections - 2013 DOE Fuel Cell Technologies Office Record 13013: H2 Delivery Cost Projections - 2013 This program record from the U.S. Department of Energy's Fuel Cell Technologies Office provides information about past, current, and projected costs for delivering and dispensing hydrogen. PDF icon DOE Hydrogen and Fuel Cells Program Record # 13013 More Documents & Publications Hydrogen Delivery Roadmap US DRIVE Hydrogen

  9. Alternative Fuels Data Center: No E85-Compatible, External Fuel Delivery

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Hose Has Been Submitted for Testing (November 2008) No E85-Compatible, External Fuel Delivery Hose Has Been Submitted for Testing (November 2008) to someone by E-mail Share Alternative Fuels Data Center: No E85-Compatible, External Fuel Delivery Hose Has Been Submitted for Testing (November 2008) on Facebook Tweet about Alternative Fuels Data Center: No E85-Compatible, External Fuel Delivery Hose Has Been Submitted for Testing (November 2008) on Twitter Bookmark Alternative Fuels Data

  10. A novel inert crystal delivery medium for serial femtosecond crystallography

    SciTech Connect (OSTI)

    Conrad, Chelsie E.; Basu, Shibom; James, Daniel; Wang, Dingjie; Schaffer, Alexander; Roy-Chowdhury, Shatabdi; Zatsepin, Nadia A.; Aquila, Andrew; Coe, Jesse; Gati, Cornelius; Hunter, Mark S.; Koglin, Jason E.; Kupitz, Christopher; Nelson, Garrett; Subramanian, Ganesh; White, Thomas A.; Zhao, Yun; Zook, James; Boutet, Sbastien; Cherezov, Vadim; Spence, John C. H.; Fromme, Raimund; Weierstall, Uwe; Fromme, Petra

    2015-06-30

    Serial femtosecond crystallography (SFX) has opened a new era in crystallography by permitting nearly damage-free, room-temperature structure determination of challenging proteins such as membrane proteins. In SFX, femtosecond X-ray free-electron laser pulses produce diffraction snapshots from nanocrystals and microcrystals delivered in a liquid jet, which leads to high protein consumption. A slow-moving stream of agarose has been developed as a new crystal delivery medium for SFX. It has low background scattering, is compatible with both soluble and membrane proteins, and can deliver the protein crystals at a wide range of temperatures down to 4C. Using this crystal-laden agarose stream, the structure of a multi-subunit complex, phycocyanin, was solved to 2.5 resolution using 300 g of microcrystals embedded into the agarose medium post-crystallization. The agarose delivery method reduces protein consumption by at least 100-fold and has the potential to be used for a diverse population of proteins, including membrane protein complexes.

  11. Colorado Natural Gas Deliveries to Electric Power Consumers (Million Cubic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) Colorado Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 6,024 6,704 8,509 7,506 6,875 7,181 8,212 7,998 6,696 8,071 5,554 6,624 2002 5,071 4,419 7,141 6,739 5,962 7,198 8,964 7,515 6,242 7,059 5,672 6,190 2003 6,527 6,160 5,955 4,403 5,813 4,759 9,648 10,010 6,344 5,751 6,145 6,380 2004 6,382 5,235 4,767 5,363 6,967 6,707 9,675 7,902 6,481 7,046

  12. Connecticut Natural Gas Deliveries to Electric Power Consumers (Million

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cubic Feet) Deliveries to Electric Power Consumers (Million Cubic Feet) Connecticut Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2001 1,038 1,552 2,452 614 1,179 1,891 2,476 4,089 5,913 4,880 2,279 3,798 2002 4,423 3,978 4,703 3,922 5,828 5,560 7,982 8,302 7,282 4,687 4,165 4,227 2003 2,459 2,060 4,165 3,486 3,226 2,869 3,891 4,415 4,211 3,757 4,363 3,666 2004 2,696 3,977 3,888 4,214 5,821 5,783 6,418 6,918 6,399

  13. U.S. Natural Gas International Deliveries (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    Deliveries (Million Cubic Feet) U.S. Natural Gas International Deliveries (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1930's 1,798 2,231 1,693 2,158 5,801 6,800 7,436 4,868 1,837 3,122 1940's 5,563 7,466 8,702 11,210 14,576 18,207 17,675 18,149 18,704 20,054 1950's 25,727 24,163 27,456 28,322 28,726 31,029 35,963 41,655 38,719 18,413 1960's 11,332 10,747 15,814 16,957 19,603 26,132 24,639 81,614 93,745 51,304 1970's 69,813 80,212 78,013

  14. A novel inert crystal delivery medium for serial femtosecond crystallography

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Conrad, Chelsie E.; Basu, Shibom; James, Daniel; Wang, Dingjie; Schaffer, Alexander; Roy-Chowdhury, Shatabdi; Zatsepin, Nadia A.; Aquila, Andrew; Coe, Jesse; Gati, Cornelius; et al

    2015-06-30

    Serial femtosecond crystallography (SFX) has opened a new era in crystallography by permitting nearly damage-free, room-temperature structure determination of challenging proteins such as membrane proteins. In SFX, femtosecond X-ray free-electron laser pulses produce diffraction snapshots from nanocrystals and microcrystals delivered in a liquid jet, which leads to high protein consumption. A slow-moving stream of agarose has been developed as a new crystal delivery medium for SFX. It has low background scattering, is compatible with both soluble and membrane proteins, and can deliver the protein crystals at a wide range of temperatures down to 4°C. Using this crystal-laden agarose stream, themore » structure of a multi-subunit complex, phycocyanin, was solved to 2.5 Å resolution using 300 µg of microcrystals embedded into the agarose medium post-crystallization. The agarose delivery method reduces protein consumption by at least 100-fold and has the potential to be used for a diverse population of proteins, including membrane protein complexes.« less

  15. The Role of Public Utility Commissions in Energy Efficiency Program Delivery

    Broader source: Energy.gov [DOE]

    This presentation, given through the DOE's Technical Assistance Program (TAP), addresses the role of public utility commissions in energy efficiency program delivery. Presented on August 31, 2011.

  16. 2011 Annual Planning Summary for Electricity Delivery and Energy Reliability (OE)

    Broader source: Energy.gov [DOE]

    The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2011 and 2012 within the Office of Electricity Delivery and Energy Reliability (OE).

  17. Safe and compact ammonia storage/delivery systems for SCR-DeNOX...

    Broader source: Energy.gov (indexed) [DOE]

    johannessen.pdf More Documents & Publications Ammonia storage and delivery systems for NOx aftertreatment 3rd Generation SCR System Using Solid Ammonia Storage and Direct Gas...

  18. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results- Interim Report

    Office of Energy Efficiency and Renewable Energy (EERE)

    An in-depth comparative analysis of promising infrastructure options for hydrogen delivery and distribution to refueling stations from central, semi-central, and distributed production facilities.

  19. U.S. Department of Energy Office of Electricity Delivery & Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    partnership to conduct research on the reliability of the nation's electricity delivery infrastructure during the transition from regulated markets to competitive markets ...

  20. Forum on Enhancing the Delivery of Energy Efficiency to Middle Income Households: Discussion Summary

    SciTech Connect (OSTI)

    none,

    2012-09-20

    Summarizes discussions and recommendations from a forum for practitioners and policymakers aiming to strengthen residential energy efficiency program design and delivery for middle income households.