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Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Echogenic Lipsomes for targeted drug delivery  

Science Conference Proceedings (OSTI)

Echogenic immunoliposomes (ELIP) are under development to enable ultrasound-controlled drug delivery. Mechanistic studies in vitro have revealed that stable cavitation is correlated with enhanced recombinant tissue Plasminogen Activator (rt-PA) thrombolysis, ...

Christy K. Holland; David D. McPherson

2009-06-01T23:59:59.000Z

2

Synthetic LDL as targeted drug delivery vehicle  

SciTech Connect

The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

Forte, Trudy M. (Berkeley, CA); Nikanjam, Mina (Richmond, CA)

2012-08-28T23:59:59.000Z

3

Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes  

E-Print Network (OSTI)

We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...

Chau, Ying

2005-01-01T23:59:59.000Z

4

Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme  

SciTech Connect

This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor.

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu,Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-06-14T23:59:59.000Z

5

Synthetic Nano-Low Density Lipoprotein as Targeted Drug Delivery Vehicle for Glioblastoma Multiforme  

E-Print Network (OSTI)

Synthetic Nano-Low Density Lipoprotein as Targeted Drugmicroemulsion; peptide; nano-low density lipoproteintherapeutic agents. A synthetic nano-LDL (nLDL) particle was

Nikanjam, Mina; Blakely, Eleanor A.; Bjornstad, Kathleen A.; Shu, Xiao; Budinger, Thomas F.; Forte, Trudy M.

2006-01-01T23:59:59.000Z

6

Optically generated ultrasound for enhanced drug delivery  

DOE Patents (OSTI)

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

Visuri, Steven R. (Livermore, CA); Campbell, Heather L. (Baltimore, MD); Da Silva, Luiz (Danville, CA)

2002-01-01T23:59:59.000Z

7

Microfabricated injectable drug delivery system  

DOE Patents (OSTI)

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

Krulevitch, Peter A. (Pleasanton, CA); Wang, Amy W. (Oakland, CA)

2002-01-01T23:59:59.000Z

8

Packaging for a drug delivery microelectromechanical system  

E-Print Network (OSTI)

Local drug delivery is a fast expanding field, and has been a center of attention for researchers in medicine in the last decade. Its advantages over systemic drug delivery are clear in cancer therapy, with localized tumors. ...

Ho Duc, Hong Linh, 1978-

2005-01-01T23:59:59.000Z

9

Design and in vitro development of resorbable urologic drug delivery device  

E-Print Network (OSTI)

Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous ...

Tobias, Irene S. (Irene Sophie)

2008-01-01T23:59:59.000Z

10

Molecular aptamers for drug delivery Weihong Tan1,2  

E-Print Network (OSTI)

University, Xiamen Fujian, 361005, China The active targeting of drugs in a cell-, tissue- or diseaseMolecular aptamers for drug delivery Weihong Tan1,2 , Hui Wang2 , Yan Chen1,2,3 , Xiaobing Zhang1, 410082, China 2 Center for Research at Bio/Nano Interface, Department of Chemistry, Department

Tan, Weihong

11

In vitro characterization of pluronic F127 and D-?-tocopheryl polyethylene glycol 1000 succinate mixed micelles as nanocarriers for targeted anticancer-drug delivery  

Science Conference Proceedings (OSTI)

Mixed micelles of Pluronic F127 and d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) in different molar ratios (10 : 0, 7 : 3, 5 : 5, and 3 : 7) were prepared to characterize this system as nanocarriers for targeted delivery of chemotherapeutic ...

Adeel Masood Butt, Mohd Cairul Iqbal Mohd Amin, Haliza Katas, Narong Sarisuta, Wasu Witoonsaridsilp, Ruthairat Benjakul

2012-01-01T23:59:59.000Z

12

An implantable device for localized drug delivery and sensing  

E-Print Network (OSTI)

There are many potential clinical applications for localized drug delivery and sensing systems, such as cancer, vaccinations, pain management, and hormone therapy. Localized drug delivery systems reduce the amount of drug ...

Daniel, Karen D

2009-01-01T23:59:59.000Z

13

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo  

E-Print Network (OSTI)

Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of all cancers today. ...

Dhar, Shanta

14

A resorbable polymeric microreservoir device for controlled release drug delivery  

E-Print Network (OSTI)

The method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. Pulsatile delivery of certain drugs and molecules (such as hormones) has been shown to more efficacious than continuous ...

Grayson, Amy Catherine Richards, 1975-

2003-01-01T23:59:59.000Z

15

Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network (OSTI)

Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to ...

Seto, Jennifer Elizabeth

2011-01-01T23:59:59.000Z

16

Computer-Aided Drug Target Search  

E-Print Network (OSTI)

Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ...

Chen, Yuzong

17

Amphiphilic linear-dendritic block copolymers for drug delivery  

E-Print Network (OSTI)

Polymeric drug delivery systems have been widely used in the pharmaceutical industry. Such systems can solubilize and sequester hydrophobic drugs from degradation, thereby increasing circulation half-life and efficacy. ...

Nguyen, Phuong, Ph. D. Massachusetts Institute of Technology

2007-01-01T23:59:59.000Z

18

Fabrication and testing analysis of tapered silicon microneedles for drug delivery applications  

Science Conference Proceedings (OSTI)

Drug delivery plays an important role in the treatment of disease, and the equipment used for drug delivery has a great impact on the delivery efficiency of drugs. Recently developed for drug delivery, the new microneedle apparatus has the potential ... Keywords: Chemical etching, Dicing saw, Drug delivery, Microneedles

Xiao-Xiao Yan, Jing-Quan Liu, Shui-Dong Jiang, Bin Yang, Chun-Sheng Yang

2013-11-01T23:59:59.000Z

19

Nanoporous silicon as drug delivery systems for cancer therapies  

Science Conference Proceedings (OSTI)

Porous silicon nanoparticles have been established as excellent candidates for medical applications as drug delivery devices, due to their excellent biocompatibility, biodegradability, and high surface area. The simple fabrication method by electrochemical ...

Sazan M. Haidary; Emma P. Córcoles; Nihad K. Ali

2012-01-01T23:59:59.000Z

20

Noninvasive quantification of drug delivery from an implantable MEMS device  

E-Print Network (OSTI)

(cont.) sensors in vivo in real time and corroborated by scintillation of urine samples. The goal of monitoring drug delivery from an implant in vivo, in real time and without disturbing the tissue environment, was ...

Johnson, Audrey M., 1976-

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

A fully implantable intracochlear drug delivery device : development and characterization  

E-Print Network (OSTI)

In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of ...

Swan, Erin Eileen Leary, 1976-

2009-01-01T23:59:59.000Z

22

Needle-free drug delivery using shock wave techniques  

E-Print Network (OSTI)

A recent advancement in the area of needle-free injection systems has been the development of devices capable of epidermal delivery of powder medications. These devices use high-pressure compressed gas to accelerate drug ...

Pavlov, Atanas (Atanas Ivanov)

2006-01-01T23:59:59.000Z

23

Computational model of local intravascular drug delivery  

E-Print Network (OSTI)

Drug-eluting stents (DES) virtually eradicate the clinical phenomena of vessel restenosis; yet, they also increase the short and long term risks for stent thrombosis. To improve their safety and efficacy, it is critical ...

Balakrishnan, Brinda

2007-01-01T23:59:59.000Z

24

Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications  

E-Print Network (OSTI)

Thermal and magnetically sensitive polymers are a new class of materials with unique properties suitable for applications in drug delivery. Specifically, these polymers can be combined with a drug reservoir to make a drug ...

Edward, Jonathan M. (Jonathan Mark)

2008-01-01T23:59:59.000Z

25

Low-Frequency Sonophoresis: Application to the Transdermal Delivery of Macromolecules and Hydrophilic Drugs  

E-Print Network (OSTI)

Importance of the field: Transdermal delivery of macromolecules provides an attractive alternative route of drug administration when compared to oral delivery and hypodermic injection because of its ability to bypass the ...

Polat, Baris E.

26

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles  

E-Print Network (OSTI)

Plant-derived Type I toxins are candidate anticancer therapeutics requiring cytosolic delivery into tumor cells. We tested a concept for two-stage delivery, whereby tumor cells precoated with an antibody-targeted gelonin ...

Su, Xingfang

27

Unveiling the Molecular Structure of the Target of Many Drugs...  

NLE Websites -- All DOE Office Websites (Extended Search)

2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Unveiling the Molecular Structure of the Target of Many Drugs DECEMBER 3, 2007 Bookmark and Share Structure...

28

Protein encapsulated magnetic carriers for micro/nanoscale drug delivery systems.  

SciTech Connect

Novel methods for drug delivery may be based on nanotechnology using non-invasive magnetic guidance of drug loaded magnetic carriers to the targeted site and thereafter released by external ultrasound energy. The key building block of this system is to successfully synthesize biodegradable, magnetic drug carriers. Magnetic carriers using poly(D,L-lactide-co-glycolide) (PLGA) or poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) as matrix materials were loaded with bovine serum albumin (BSA) by a double-emulsion technique. BSA-loaded magnetic microspheres were characterized for size, morphology, surface charge, and magnetization. The BSA encapsulation efficiency was determined by recovering albumin from the microspheres using dimethyl sulfoxide and 0.05N NaOH/0.5% SDS then quantifying with the Micro-BCA protein assay. BSA release profiles were also determined by the Micro-BCA protein assay. The microspheres had drug encapsulation efficiencies up to 90% depending on synthesis parameters. Particles were spherical with a smooth or porous surface having a size range less than 5 {mu}m. The surface charge (expressed as zeta potential) was near neutral, optimal for prolonged intravascular survival. The magnetization of these BSA loaded magnetic carriers was 2 to 6 emu/g, depending on the specific magnetic materials used during synthesis.

Xie, Y.; Kaminski, M. D.; Mertz, C. J.; Finck, M. R.; Guy, S. G.; Chen, H.; Rosengart, A. J.; Chemical Engineering; Univ. of Chicago, Pritzker School of Medicine

2005-01-01T23:59:59.000Z

29

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

30

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication and is a prime target of antibacterial and anticancer drugs. Researchers at Berkeley Lab and the University of California, Berkeley, have produced the first three-dimensional structural images of a DNA-bound type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cell's DNA is fatal to the cell, which is why drugs that target topo II serve as agents against bacterial infections and some forms of cancer. This first ever structural image of topo II should help in the development of future antibacterial and anticancer drugs that are even more effective and carry fewer potential side effects.

31

Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device  

E-Print Network (OSTI)

The goal of this thesis was to advance an implantable drug delivery MEMS (MicroElectroMechanical Systems) device developed in our laboratory. This device was designed to locally deliver multiple substances in complex release ...

Li, Yawen, 1972-

2005-01-01T23:59:59.000Z

32

Lipids in NanotechnologyChapter 9 Lipid Nanoparticulate Drug Delivery and Nanomedicine  

Science Conference Proceedings (OSTI)

Lipids in Nanotechnology Chapter 9 Lipid Nanoparticulate Drug Delivery and Nanomedicine Food Science Health Nutrition Biochemistry Processing eChapters Food Science & Technology Health - Nutrition - Biochemistry Processing 4F7335F5A

33

Application of microfluidic emulsion technology to biochemistry, drug delivery and Lab-on-a-Chip programmability  

E-Print Network (OSTI)

This research applies microfluidic emulsion technology to three diverse problems; biochemistry, drug delivery and lab-on-a-chip programmability. These subjects represent distinct research programs, but the underlying physics ...

Urbanski, John Paul

2005-01-01T23:59:59.000Z

34

Engineering targeted proteins for intracellular delivery of biotherapeutics  

E-Print Network (OSTI)

Biotherapeutics have revolutionized medicine with their ability to achieve unprecedented molecular recognition and mediate complex biological responses. The intracellular delivery of biotherapeutics is an unmet scientific ...

Pirie, Christopher M

2011-01-01T23:59:59.000Z

35

Toward a drug delivery coating for intraocular lenses  

E-Print Network (OSTI)

Layer-by-layer assembly has become a quintessential tool for the creation of versatile, dynamic nanostructured materials able to dictate cellular behavior through exquisite surface functionality and delivery of bioactive ...

Smith, Renée Chivon

2010-01-01T23:59:59.000Z

36

Biocompatibility of an implantable ophthalmic drug delivery device  

E-Print Network (OSTI)

Diseases of the posterior eye present clinicians with a treatment challenge mainly due to the region's inaccessible location. Several drugs, including those available for the treatment of exudative age-related macular ...

Cohen, Sarah J. (Sarah Jennifer)

2007-01-01T23:59:59.000Z

37

Targeted and stimuli-responsive polymers as chemotherapeutic delivery systems  

E-Print Network (OSTI)

Successful administration of chemotherapeutic agents for cancer treatment requires a balance between the efficacy and the safety of the drug. This often limits physicians to a very narrow therapeutic window. To avoid the ...

Zaman, Noreen Tasneem

2008-01-01T23:59:59.000Z

38

Protein engineering for targeted delivery of radionuclides to tumors  

E-Print Network (OSTI)

Traditional cancer treatment strategies include systemic chemotherapy, external beam radiation, and surgical excision. Chemotherapy is nonspecific, and targets all rapidly dividing cells. External beam radiation and surgery ...

Orcutt, Kelly Davis

2010-01-01T23:59:59.000Z

39

DEVELOPMENT AND EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR LORNOXICAM  

E-Print Network (OSTI)

Aim of the present work was to develop and evaluate a solid self-emulsifying drug delivery system (SEDDS) for oral poorly water-soluble drug lornoxicam. The liquid (SEDDS) consisted of capmul MCM as oil phase, tween 20 as surfactant and PEG 400 as co-surfactant. Oil, surfactant and co-surfactant were selected on the basis of solubilisation capacity of drug and emulsification ability of surfactant and co-surfactants. The formulations were optimized by constructing the pseudo-ternary phase diagram. The liquid formulation was solidified by laboratory scale spray dryer, using Aerosil 200 as solid carrier. The solid SEDDS shows greater drug release thus, solid SEDDS improves the oral bioavailability and may provide the useful solid dosage form for oral poorly water soluble drugs.

V. V. Chopade; P. D. Chaudhari

2013-01-01T23:59:59.000Z

40

Double iterative optimisation for metabolic network-based drug target identification  

Science Conference Proceedings (OSTI)

The goal of drug discovery is to find molecules that manipulate enzymes in order to increase or decrease the production of desired compounds while incurring minimum side-effects. An important part of this problem is the identification of the target ... Keywords: E coli, bioinformatics, data mining, drug discovery, drug target identification, iterative optimisation, metabolic networks, target enzymes

Bin Song; Padmavati Sridhar; Tamer Kahveci; Sanjay Ranka

2009-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

In silico identification of putative drug targets in pseudomonas aeruginosa through metabolic pathway analysis  

Science Conference Proceedings (OSTI)

Comparative genomic analysis between pathogens and the host Homo sapiens has led to identification of novel drug targets. Microbial drug target identification and validation has been the latest trend in pharmacoinformatics. In order to identify a suitable ... Keywords: KEGG, MODELLER, comparative microbial genomics, homo sapiens, homology, kdsA, kdsB, lpxC, potential drug targets, pseudomonas aeruginosa, waaG

Deepak Perumal; Chu Sing Lim; Meena K. Sakharkar

2007-10-01T23:59:59.000Z

42

A Key Target for Diabetes Drugs | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Molten Metal Solidifies into a New Kind of Glass Molten Metal Solidifies into a New Kind of Glass Organic Polymers Show Sunny Potential A New Family of Quasicrystals Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Key Target for Diabetes Drugs JULY 26, 2013 Bookmark and Share The structure of the human glucagon receptor, which could help scientists design new drugs for type 2 diabetes. (Image courtesy of Katya Kadyshevskaya, The Scripps Research Institute) The three-dimensional (3-D) atomic structure of the human glucagon receptor has been identified by an international team of researchers carrying out

43

Lipids in NanotechnologyChapter 8 Lipid Nano-vehicles Based on Lyotropic Liquid Crystals as Drug Delivery Vehicles  

Science Conference Proceedings (OSTI)

Lipids in Nanotechnology Chapter 8 Lipid Nano-vehicles Based on Lyotropic Liquid Crystals as Drug Delivery Vehicles Food Science Nutrition Biochemistry Processing eChapters Food Science & Technology Health - Nutrition - Biochemistry P

44

Drug Delivery  

Science Conference Proceedings (OSTI)

Oct 17, 2011 ... Rapid, accurate cancer cell sorting from solid tumor biopsies is an area of ... In this research we have synthesized multifunctional calcium ...

45

Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection  

SciTech Connect

The central theme of this dissertation is represented by the versatility of mesoporous silica nanomaterials in various applications such as catalysis and bio-applications, with main focus on biological applications of Mesoporous Silica Nanospheres (MSN). The metamorphosis that we impose to these materials from catalysis to sensing and to drug and gene delivery is detailed in this dissertation. First, we developed a synthetic method that can fine tune the amount of chemically accessible organic functional groups on the pores surface of MSN by exploiting electrostatic and size matching between the cationic alkylammonium head group of the cetyltrimethylammonium bromide (CTAB) surfactant and various anionic organoalkoxysilane precursors at the micelle-water interface in a base-catalyzed condensation reaction of silicate. Aiming nature imitation, we demonstrated the catalytic abilities of the MSNs, We utilized an ethylenediamine functional group for chelating Cu{sup 2+} as a catalytic functional group anchored inside the mesopores. Thus, a polyalkynylene-based conducting polymer (molecular wire) was synthesized within the Cu-functionalized MSNs silica catalyst. For sensing applications, we have synthesized a poly(lactic acid) coated mesoporous silica nanosphere (PLA-MSN) material that serves as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. We exploited the mesoporosity of MSNs for encapsulating pharmaceutical drugs. We examined bio-friendly capping molecules such as polyamidoamine dendrimers of generations G2 to G4, to prevent the drug leaching. Next, the drug delivery system employed MSNs loaded with Doxorubicin, an anticancer drug. The results demonstrated that these nano-Trojan horses have ability to deliver Doxorubicin to cancer cells and induce their death. Finally, to demonstrate the potential of MSN as an universal cellular transmembrane nanovehicle, we anchored positively charged dendrimers on the surface of MSN and utilize them to complex cationic DNA. The p-EGFP-CI gene-coated MSN nanocomposite was able to transfect cancer cell lines, such as human HeLa and CHO cancer cell lines. The gene carrier ability of MSNs was further proved by transfecting primary cells and cotransfecting of two different genes in cancer cell lines. In sum, MSN are versatile partners in several types of applications.

Daniela Rodica Radu

2005-12-19T23:59:59.000Z

46

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs  

E-Print Network (OSTI)

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, China; b Department University, Chongqing 400715, China; and e Department of Pathology and Laboratory Medicine, Shands Cancer

Tan, Weihong

47

TARGETED DRUG DELIVERY TO HUMAN AORTIC SMOOTH MUSCLE CELLS USING BIODEGRADABLE NANOPARTICLES  

E-Print Network (OSTI)

First of all, I would like to thank Dr. Nguyen for giving me an opportunity to work in her laboratory as an undergraduate McNair student; and for allowing me to continue to work for her over the past few years. Without her advice and direction I would not have the appreciation for research as I do today. Moreover, it would have been difficult to complete this project without her dedication. I also thank Dr. Chuong and Dr. Yang for serving as my committee members. Furthermore, I thank each of you for your cooperation in adjusting your schedules to attend my defense. Additionally, I want to thank the students in the Nanomedicine and Tissue laboratory for all of their assistance whenever I was having difficulties and required help, especially those who were available this summer. In particular I would like to thank Maham Rahimi for his guidance over the past few years. Last, but not least, I thank my family because without them I would not be where I am today. I am truly grateful and appreciate all the love and support you given me.

Danyel Specht; Danyel Specht M. S

2008-01-01T23:59:59.000Z

48

Drug delivery from hydrophobic-modified mesoporous silicas: Control via modification level and site-selective modification  

SciTech Connect

Dimethylsilyl (DMS) modified mesoporous silicas were successfully prepared via co-condensation and post-grafting modification methods. The post-grafting modification was carried out by the reaction of the as-synthesized MCM-41 material (before CTAB removal) with diethoxydimethylsinale (DEDMS). N{sub 2} adsorption-desorption and {sup 29}Si MAS NMR characterization demonstrated that different amount of DMS groups were successfully incorporated into the co-condensation modified samples, and the functional DMS groups were placed selectively on the pore openings and external pore surfaces in the post-grafting modified samples. Subsequently, the controlled drug delivery properties from the resulting DMS-modified mesoporous silicas were investigated in detail. The drug adsorption experiments showed that the adsorption capacities were mainly depended on the content of silanol group (CSG) in the corresponding carriers. The in vitro tests exhibited that the incorporation of DMS groups greatly retarded the ibuprofen release rate. Moreover, the ibuprofen release profiles could be well modulated by varying DMS modification levels and site-selective distribution of functional groups in mesoporous carriers. - The distribution of DMS groups on the pore surfaces of the mesostructures strongly affects the drug release rate. The P-M41-1 and the P-M41-2 possess the close DMS modification levels as the C-M41-10, but the ibuprofen release rates from the P-M41-1 and P-M41-2 are much slower than that from the C-M41-10.

Tang Qunli, E-mail: tangqunli@hnu.c [College of Materials Science and Engineering, and Center for High-Resolution Electron Microscopy, Hunan University, Changsha 410082 (China); State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001 (China); Chen Yuxi; Chen Jianghua; Li Jin [College of Materials Science and Engineering, and Center for High-Resolution Electron Microscopy, Hunan University, Changsha 410082 (China); Xu Yao; Wu Dong; Sun Yuhan [State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001 (China)

2010-01-15T23:59:59.000Z

49

Kilogram Scale Synthesis of a Triazine-based Dendrimer and the Development of a General Strategy for the Installation of Pharmacophores to Yield Potential Drug Delivery Agents  

E-Print Network (OSTI)

Diverse dendrimer peripheries are often produced through convergent synthesis with multiple protection-deprotection steps. Achieving such diversity while maintaining monodispersity, has previously proven problematic. Interception of an electrophilic poly(monochlorotriazine) dendrimer with a molecule of interest bearing a reactive, nucleophilic group presents an efficient method to achieve large quantities of dendrimers with biologically relevant peripheries. Kilogram-scale synthesis of a triazine-based dendrimer relies on reaction of the dichlorotriazine monomer with the amine terminated dendrimer to afford a poly(monochlorotriazine) dendrimer. Normally, the dendrimer is then reacted with piperidine, an inexpensive “cap” due to its chemically inert nature after reaction. The dendrimer then undergoes a global deprotection to afford an amine-terminated dendrimer. Subsequent iterations with the dichlorotriazine monomer affords higher generation architectures. Intercepting the poly(monochlorotriazine) dendrimer with biologically relevant molecules containing reactive amines enables the development of a drug delivery vehicle. Desferrioxamine B, an iron chelate, and camptothecin, and anticancer drug, are two clinically approved drugs of interest investigated for macromolecular drug delivery. Upon acylation of each drug with BOC-isonipecotic acid, substitution on the dendrimer may occur with varying levels of success depending on the drug in question. Upon successful substitution to afford the desired product,biological studies may be performed. Each synthetic approach will be discussed along with alternative routes leading to this general strategy.

Venditto, Vincent J.

2009-12-01T23:59:59.000Z

50

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers http://www.bioportfolio.com/news/article/620380/The-Targeted-Delivery-Of-Multicomponent-Cargos-To-Cancer-Cells-By-Nanoporous-Particle.html[4/21/  

E-Print Network (OSTI)

, Markets And Compani... Complete Target Atlas In Oncology Drug Development: From Tumor T... Reports | Researchers report on the development of a new class of high-capacity drug carrier they claim combines/Oxide Hybrid Electrodes For Electrochemical Supercapacitors Nature | Instant access to this article: US$18 Buy

Brinker, C. Jeffrey

51

A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy  

E-Print Network (OSTI)

The use of nanotechnology to engineer drug delivery vehicles comprised of controlled release polymers with targeting molecules has the potential to revolutionize cancer therapy, among other diseases. Although a myriad of ...

Valencia, Pedro M. (Pedro Miguel)

2013-01-01T23:59:59.000Z

52

Pilot study of inhaled aerosols targeted via magnetic alignment of high aspect ratio particles in rabbits  

Science Conference Proceedings (OSTI)

Recently, inhaled pharmaceutical aerosols have seen increased investigation in the treatment of lung cancer, where the inability to deliver adequate therapeutic drug concentrations to tumour sites may be overcome with improved targeted delivery to the ...

Gillian E. S. Redman; Andrew R. Martin; Paul Waszak; Richard B. Thompson; Po-Yin Cheung; Bernard Thébaud; Warren H. Finlay

2011-01-01T23:59:59.000Z

53

Articulating feedstock delivery device  

DOE Patents (OSTI)

A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

Jordan, Kevin

2013-11-05T23:59:59.000Z

54

Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery  

E-Print Network (OSTI)

Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what ...

Vukmirovic, Neda

2007-01-01T23:59:59.000Z

55

Efficient in vitro TRAIL-gene delivery in drug-resistant A2780/DDP ovarian cancer cell line via magnetofection  

Science Conference Proceedings (OSTI)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) presents great promise as an anticancer agent for human cancer therapy. In this study, a magnetofection agent (polyMAG-l000) was evaluated for in vitro delivery of TRAIL gene towards drugresistant ...

Fang Li; Sumei Niu; Jing Sun; Huaishi Zhu; Qiujie Ba; Yi Guo; Donglu Shi

2011-01-01T23:59:59.000Z

56

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and  

E-Print Network (OSTI)

Background: The Inflammasomes are multi-protein complexes that regulate caspase-1 activation and the production of the pro-inflammatory cytokine IL-1b. Previous studies identified a class of diarylsulfonylurea containing compounds called Cytokine Release Inhibitory Drugs (CRIDs) that inhibited the post-translational processing of IL-1b. Further work identified Glutathione S-Transferase Omega 1 (GSTO1) as a possible target of these CRIDs. This study aimed to investigate the mechanism of the inhibitory activity of the CRID CP-456,773 (termed CRID3) in light of recent advances in the area of inflammasome activation, and to clarify the potential role of GSTO1 in the regulation of IL-1b production. Methodology and Results: In murine bone marrow derived macrophages, CRID3 inhibited IL-1b secretion and caspase 1 processing in response to stimulation of NLRP3 and AIM2 but not NLRC4. CRID3 also prevented AIM2 dependent pyroptosis in contrast to the NLRP3 inhibitors glyburide and parthenolide, which do not inhibit AIM2 activation. Confocal microscopy and Western blotting assays indicated that CRID3 inhibited the formation of ASC complexes or ‘specks ’ in response to NLRP3 and AIM2 stimulation. Co-immunoprecipitation assays show that GSTO1 interacted with ASC. Significance: These results identify CRID3 as a novel inhibitor of the NLRP3 and AIM2 inflammasomes and provide an insight into the mechanism of action of this small molecule. In addition GSTO1 may be a component of the inflammasome

Aim Inflammasomes; Rebecca C. Coll; Luke A. J. O’neill

2011-01-01T23:59:59.000Z

57

Bacterial magnetosome: a novel biogenetic magnetic targeted drug carrier with potential multifunctions  

Science Conference Proceedings (OSTI)

Bacterial magnetosomes (BMs) synthesized by magnetotactic bacteria have recently drawn great interest due to their unique features. BMs are used experimentally as carriers for antibodies, enzymes, ligands, nucleic acids, and chemotherapeutic drugs. In ...

Jianbo Sun; Ying Li; Xing-Jie Liang; Paul C. Wang

2011-01-01T23:59:59.000Z

58

Multi-functional Bio-synthetic Hybrid Nanostructures for Enhanced Cellular Uptake, Endosomal Escape and Targeted Delivery Toward Diagnostics and Therapeutics  

E-Print Network (OSTI)

Applications of nanotechnology in medicine, also known as nanomedicine, is a rapidly growing field as it holds great potential in the development of novel therapeutics toward treatment of various diseases. Shell crosslinked knedel-like nanoparticles (SCKs) that are self assembled from amphiphilic block copolymers into polymeric micelles followed by crosslinking selectively throughout the shell domain have been investigated as theranostic agents for the delivery of nucleic acids and incorporation of imaging probes. The main focus of this dissertation is to design and develop unique multifunctional bio-synthetic hybrid nanoparticles that can carry agents for radiolabeling, moieties for inducing stealth properties to minimize protein adsorption in vivo, ligands for site-specific targeting, therapeutic payloads, and are optimized for efficient delivery of cargoes intracellularly and to the target sites toward constructing novel nanoscopic objects for therapy and diagnosis. Alteration of polymeric building blocks of the nanoparticles provides opportunities for precise control over the sizes, shapes, compositions, structures and properties of the nanoparticles. To ensure ideal performance of nanoparticles as theranostic agents, it is critical to ensure high intracellular bioavailability of the therapeutic payload conjugated to nanoparticles. Special efforts were made by employing well-defined multi-step polymerization and polymer modification reactions that involved conjugation of peptide nucleic acids (PNAs) to chain terminus of poly(ethylene glycol) (PEG) chain grafts such that they were presented at the outermost surface of SCKs. Additionally, chemical modification reactions were performed on the polymer backbone to integrate positive charges onto the shell of the nanoparticles to afford cationic SCKs (cSCKs) for facilitating cellular entry and electrostatic interactions with negatively charged nucleic acids. Covalent conjugation of F3, a tumor homing peptide, post-assembly of the nanoparticles enhanced cellular uptake and knockdown of nucleolin (a shuttling protein overexpressed at the sites of angiogenesis) and thus inhibiting tumor cell growth. Furthermore, these polymer precursors of the cSCKs were modified with partial to full incorporation of histamines to facilitate their endosomal escape for efficient delivery into the cytosol. The cSCKs were further templated onto high aspect ratio anionic cylinders to form hierarchically-assembled nanostructures that bring together individual components with unique functions, such as one carrying a therapeutic payload and the other with sites for radiolabeling. These higher order nanoobjects enhance circulation in vivo, have capabilities to package nucleic acids electrostatically and contain sites for radiolabeling, providing an overall advantage over the individual components, which could each facilitate only one or the other of the combined functions. Hierarchically-assembled nanostructures were investigated for their cellular uptake, transfection behavior and radiolabeling efficiency, as the next generation of theranostic agents.

Shrestha, Ritu 1984-

2012-12-01T23:59:59.000Z

59

Membrane protein kit may lead to better targeted drugs | Argonne National  

NLE Websites -- All DOE Office Websites (Extended Search)

Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Argonne biologists Deborah Hanson and Phil Laible developed a kit that enables its users to easily generate large amounts of membrane proteins. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne scientists received an R&D100 Award for using Rhodobacter to develop a new system for growing membrane proteins used in drug discovery research. Image by Sheng-Wen Chui, University of Oxford. To view a larger version of the image, click on it. Filamentous cells of the bacterium Rhodobacter sphaeroides. Argonne

60

Target  

NLE Websites -- All DOE Office Websites (Extended Search)

Lifetime measurements in Lifetime measurements in inverse kinematics Coulex Target e.g. C Stopper e.g. Cu Beam X X * C Si-Det. Yale Plunger 120 Te at 300 MeV Plunger foils Si-Detector Compton-suppressed Clover detectors (8) 50% Coulomb- barrier )] ( exp[ 1 ) ( 0 d d d P - - - = λ Probability of emitting gamma-ray while in-flight: From data: ) ( ) ( ) ( ) ( ) ( d I d I d P total shifted γ γ = where ) ( ) ( γ γ γ γ θ ε W E N I = Lifetime analysis For example: Valence proton symmetry Data from NNDC, WNSL ( 120 Te), NBI group ( 116 Te), Cologne ( 114 Te) B(E2)up [e 2 b 2 ] N A.A. Pasternak et al., EPJA 13, 435 (2002) O. Möller et al., PRC 71, 064324 (2005) Study deviations from (collective) expectations -> needs a fast and easy way to obtain data -> inverse RDDS well suited! Important in inverse kinematics: Deorientation F I J Large v/c => except for relativistic

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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61

Hydrogen Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Mark Paster Energy Efficiency and Renewable Energy Hydrogen, Fuel Cells and Infrastructure Technology Program Hydrogen Production and Delivery Team Hydrogen Delivery Goal Hydrogen Delivery Goal Liquid H 2 & Chem. Carriers Gaseous Pipeline Truck Hydrides Liquid H 2 - Truck - Rail Other Carriers Onsite reforming Develop Develop hydrogen fuel hydrogen fuel delivery delivery technologies that technologies that enable the introduction and enable the introduction and long long - - term viability of term viability of hydrogen as an energy hydrogen as an energy carrier for transportation carrier for transportation and stationary power. and stationary power. Delivery Options * End Game - Pipelines - Other as needed * Breakthrough Hydrogen Carriers * Truck: HP Gas & Liquid Hydrogen

62

Document Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery The Research Library can order journal articles, conference papers and book chapters not found in the Library collection for LANL staff. The service is provided by...

63

Gaseous Hydrogen Delivery Breakout - Strategic Directions for Hydrogen Delivery Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Gaseous Hydrogen Gaseous Hydrogen Delivery Breakout Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Breakout Session Name Targets/Objectives More work is needed to better define delivery target metrics Assumptions about targets for costs and energy efficiency need to be qualified Technology improvements likely to lower costs, but may not have major impact on total cost A significant impact on cost would come through permitting policy changes, e.g., use of public land Breakout Session Name Priority Barriers System Issues: need to assess delivery options in context of total system Materials: corrosion, H2 permeability Construction: welding, joining Maintenance and Operation: leak detection Pipeline Safety: odorants, flame visibility

64

Self-assembled pentablock copolymers for selective and sustained gene delivery  

SciTech Connect

The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

Zhang, Bingqi

2011-05-15T23:59:59.000Z

65

Measured Laboratory and In-Use Fuel Economy Observed over Targeted Drive Cycles for Comparable Hybrid and Conventional Package Delivery Vehicles  

Science Conference Proceedings (OSTI)

In-use and laboratory-derived fuel economies were analyzed for a medium-duty hybrid electric drivetrain with 'engine off at idle' capability and a conventional drivetrain in a typical commercial package delivery application. Vehicles studied included eleven 2010 Freightliner P100H hybrids in service at a United Parcel Service facility in Minneapolis during the first half of 2010. The hybrids were evaluated for 18 months against eleven 2010 Freightliner P100D diesels at the same facility. Both vehicle groups use the same 2009 Cummins ISB 200-HP engine. In-use fuel economy was evaluated using UPS's fueling and mileage records, periodic ECM image downloads, and J1939 CAN bus recordings during the periods of duty cycle study. Analysis of the in-use fuel economy showed 13%-29% hybrid advantage depending on measurement method, and a delivery route assignment analysis showed 13%-26% hybrid advantage on the less kinetically intense original diesel route assignments and 20%-33% hybrid advantage on the more kinetically intense original hybrid route assignments. Three standardized laboratory drive cycles were selected that encompassed the range of real-world in-use data. The hybrid vehicle demonstrated improvements in ton-mi./gal fuel economy of 39%, 45%, and 21% on the NYC Comp, HTUF Class 4, and CARB HHDDT test cycles, respectively.

Lammert, M. P.; Walkowicz, K.; Duran, A.; Sindler, P.

2012-10-01T23:59:59.000Z

66

A human biotin acceptor domain allows site-specific conjugation of an enzyme to an antibody-avidin fusion protein for targeted drug delivery  

E-Print Network (OSTI)

Asai, Ryan Trinh, Patrick P. Ng, Manuel L. Penichet, LetitiaJ Immunol 1999;163:4421–6. [12] Ng PP, Dela Cruz JS, Sorour

Asai, T; Trinh, R; Ng, P P; Penichet, M L; Wims, L A; Morrison, S L

2005-01-01T23:59:59.000Z

67

Liquid Hydrogen Delivery - Strategic Directions for Hydrogen Delivery Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Hydrogen Hydrogen Delivery Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Main Themes/Caveats Will be challenging (if not impossible) to meet the 2010 cost target with today's technology Without significant growth in product demand, progress will likely be slow even with incremental technology Group a little light on technical expertise, but feel captured main ideas required Less "weeding" of ideas, but more divergent thinking Targets/Objectives 2003 Status: $1.11/kg May be a bit lower than actual costs Baseline needs to be revisited 2005 Target: $1.01/kg Technically (10% improvement) could be met, but unlikely demand drivers will be present to encourage meeting target Likely no plant will be built in 2005

68

EXPERT REVIEW Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release  

E-Print Network (OSTI)

ABSTRACT Micelles are colloidal particles with a size around 5–100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a ‘magic bullet ’ a major step forward. KEY WORDS imaging. micelles. nanomedicine. theranostics. triggered release

C. Oerlemans

2010-01-01T23:59:59.000Z

69

Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport  

E-Print Network (OSTI)

Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to ...

Tang, Hua, 1972-

2002-01-01T23:59:59.000Z

70

Lorentz-force actuated needle-free injection for intratympanic pharmaceutical delivery  

E-Print Network (OSTI)

Delivery of pharmaceuticals to the inner ear via injection through the tympanic membrane is a method of local drug delivery that provides a non-invasive, outpatient procedure to treat many of the disorders and diseases ...

Cloutier, Alison (Alison Marie)

2013-01-01T23:59:59.000Z

71

Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth  

E-Print Network (OSTI)

Assembly of functional nanocomponents offers promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery ...

Wong, Cliff R. (Cliff Richard)

2011-01-01T23:59:59.000Z

72

Hydrogen Delivery Analysis Models  

NLE Websites -- All DOE Office Websites (Extended Search)

model for delivery system component costs and performance: Components Model Delivery scenario model for Urban and Rural Interstate markets and demand levels (Mkt....

73

LNG – Engine Delivery  

This is a method of improved delivery of liquid natural gas (LNG) within an engine delivery system. The LNG gas is first be pumped into the insulated ...

74

Molecule Nanoweaver Improves Drug Delivery and Treatment ...  

... the Molecule Nanoweaver could be used to optimize and produce a heart-muscle stimulator patch that provides low-level electrical stimulation from ...

75

Ultrasonic Drug Delivery - Industrial Partnerships Office  

City of Livermore. Community. Our Community. Discovery Center. Site Tours. LLNL Community News. ... LLC, for the Department of Energy's National Nucle ...

76

BiOmaterialS Drug delivery  

E-Print Network (OSTI)

.mri.psu.edu or the Industrial Research Office web site at www.techtransfer.psu.edu/iro/ Message from The Director In This Issue

Andrews, Anne M.

77

Artificial Cells for Advanced Drug Delivery - Energy ...  

The zinc salt may be zinc nitrate hexahydrate, the first additive may be benzyl alcohol and the second additive may be urea. ... manufacturing, ...

78

Drug delivery device for bladder disorders  

E-Print Network (OSTI)

Several pathologies associated with the bladder have wide impacts on society. Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are chronic urological conditions characterized by pain, ...

Lee, Heejin, 1976-

2009-01-01T23:59:59.000Z

79

FCT Hydrogen Delivery: Hydrogen Delivery R&D Activities  

NLE Websites -- All DOE Office Websites (Extended Search)

Hydrogen Delivery R&D Activities to someone by E-mail Share FCT Hydrogen Delivery: Hydrogen Delivery R&D Activities on Facebook Tweet about FCT Hydrogen Delivery: Hydrogen Delivery...

80

Surface Functionalized Nanoparticles for Targeted Delivery and ...  

Science Conference Proceedings (OSTI)

... Templates Facilitates Neural Stem Cell Adhesion, Proliferation and Differentiation ... Improving the Resistance of Ceramic Surfaces to Biofilm Formation ... Sol-Gel Synthesis of Bio-Active Nanoporous Sodium Zirconate Coated on 316L ...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs  

E-Print Network (OSTI)

Introduction: Effective local drug delivery to contractile tissues such as skeletal muscle requires a thorough understanding of the impact of mechanical loads on intramuscular pharmacokinetics. Current preparations for ...

Wu, Peter I-Kung

2007-01-01T23:59:59.000Z

82

DOI: 10.1002/cmdc.200700121 Co-Delivery of Hydrophobic and  

E-Print Network (OSTI)

NP drug delivery system that bridges these two simple concepts to co-deliver both hydro- phobic acting as fast releasing car- riers for hydrophilic intercalating drugs, and 2) polymeric NPs that act

Zhang, Liangfang

83

UIC Developing Drug for SARS  

NLE Websites -- All DOE Office Websites (Extended Search)

but their backbones. When viruses mutate, as they frequently do, thwarting the action of drugs, the mutations typically occur in these sidechains. "By targeting the backbone, we...

84

Energy Storage & Delivery  

Science Conference Proceedings (OSTI)

Energy Storage & Delivery. Summary: Schematic of Membrane Molecular Structure The goal of the project is to develop ...

2013-07-23T23:59:59.000Z

85

Fuel Cell Technologies Office: Strategic Directions for Hydrogen Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Strategic Directions for Hydrogen Delivery Workshop Strategic Directions for Hydrogen Delivery Workshop The U.S. Department of Energy sponsored a Hydrogen Delivery Workshop in Washington, DC, May 7-8, 2003. Attendees included researchers, government officials, and industry members. A key element of the overall hydrogen energy infrastructure is the delivery system that moves the hydrogen from its point of production to an end-use device. The DOE's Fuel Cell Technologies Office will initiate, in fiscal year 2004, a research program targeted specifically at addressing hydrogen transportation and delivery. This special workshop was held to outline the future technology and research needs for developing cost-effective, reliable, and safe hydrogen delivery systems. The proceedings of the Hydrogen Delivery Workshop, which include the presentations and the recommendations of the four breakout groups, are available as Adobe Acrobat PDFs. Download Adobe Reader.

86

Evaluation of Retrofit Delivery Packages  

SciTech Connect

Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

Berman, M.; Smith, P.; Porse, E.

2013-07-01T23:59:59.000Z

87

FCT Hydrogen Delivery: Basics  

NLE Websites -- All DOE Office Websites (Extended Search)

distributed production facilities have relatively low delivery costs, but the hydrogen production costs are likely to be higher-lower volume production means higher equipment...

88

Prescription Drugs  

NLE Websites -- All DOE Office Websites (Extended Search)

Prescription Drugs Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are different for formulary or non-formulary, generic, or brand/preferred name. Review the BCBSNM Drug List (pdf) to find out which tier a specific drug falls under. Co-pays Prescription drug co-pays vary from plan to plan. 2013 EPO Summary of Benefits (pdf) 2013 PPO Summary of Benefits (pdf)

89

Vulnerability Analysis of Energy Delivery Control Systems - 2011 |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vulnerability Analysis of Energy Delivery Control Systems - 2011 Vulnerability Analysis of Energy Delivery Control Systems - 2011 Vulnerability Analysis of Energy Delivery Control Systems - 2011 Cybersecurity for energy delivery systems has emerged as one of the Nation's most serious grid modernization and infrastructure protection issues. Cyber adversaries are becoming increasingly targeted, sophisticated, and better financed. The energy sector must research, develop and deploy new cybersecurity capabilities faster than the adversary can launch new attack tools and techniques. The goal of the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability (DOE/OE) National Supervisory Control and Data Acquisition (SCADA) Test Bed (NSTB) program is to enhance the reliability and resiliency of the Nation's energy infrastructure by reducing the risk

90

A18: Effect of Local Alendronate Delivery on In Vivo Osteogenesis ...  

Science Conference Proceedings (OSTI)

One of the major challenges of local drug delivery is uncontrolled and burst release. ... B30: Infrared Spectra and X-Ray Photoelectron Spectroscopy Study of .... H18: Comparaison of a Gamma Titanium Aluminide Fabricated by LENS, SLM

91

VIA EMAIL DELIVERY  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

VIA EMAIL DELIVERY VIA EMAIL DELIVERY March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability U.S. Department of Energy 1000 Independence Avenue SW Washington, D.C. 20585 Lamont.Jackson@hq.doe.gov Re: Request for Information, OE Docket No. RRTT-IR-001, Rapid Response Team for Transmission Dear Mr. Jackson: TransWest Express LLC (TransWest) appreciates the opportunity to respond to the Department of Energy's questions related to permitting transmission lines, as outlined in the February 27, 2012, Federal Register notice. Per your request, the role of our company in the electric sector is as follows. TransWest is an independent transmission developer that is focused on permitting and developing the TransWest Express Transmission Project (TWE Project). The TWE Project is one of the seven

92

Hydrogen Delivery Roadmap  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery Delivery Technical Team Roadmap June 2013 This roadmap is a document of the U.S. DRIVE Partnership. U.S. DRIVE (United States Driving Research and Innovation for Vehicle efficiency and Energy sustainability) is a voluntary, non-binding, and nonlegal partnership among the U.S. Department of Energy; United States Council for Automotive Research (USCAR), representing Chrysler Group LLC, Ford Motor Company, and General Motors; Tesla Motors; five energy companies - BPAmerica, Chevron Corporation, Phillips 66 Company, ExxonMobil Corporation, and Shell Oil Products US; two utilities - Southern California Edison and DTE Energy; and the Electric Power Research Institute (EPRI). The Hydrogen Delivery Technical Team is one of 12 U.S. DRIVE technical teams ("tech teams") whose

93

Fuel Cell Technologies Office: Hydrogen Delivery  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

| Consumer Information Hydrogen Delivery Search Search Help Hydrogen Delivery EERE Fuel Cell Technologies Office Hydrogen Delivery Printable Version Share this resource...

94

TRANSFORMING ELECTRICITY DELIVERY | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

TRANSFORMING ELECTRICITY DELIVERY TRANSFORMING ELECTRICITY DELIVERY Designing research, development, and demonstration programs based on a future look at electric power delivery...

95

Energy Delivery Systems Cybersecurity | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Cybersecurity Energy Delivery Systems Cybersecurity Energy Delivery Systems Cybersecurity About the Cybersecurity for Energy Delivery Systems Program A key mission of the...

96

Targeting of drugs and nanoparticles to tumors  

E-Print Network (OSTI)

The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as ...

Ruoslahti, Erkki

97

Categorical Exclusion Determinations: Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Electricity Delivery and Energy Reliability Categorical Exclusion Determinations: Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations issued...

98

Production Targets  

E-Print Network (OSTI)

Hall (2005), “Prices, Production, and Inventories over theProduction Targets ? Guillermo Caruana CEMFI caruana@cem?.esthe theory using monthly production targets of the Big Three

Caruana, Guillermo; Einav, Liran

2005-01-01T23:59:59.000Z

99

Delivery Tech Team  

NLE Websites -- All DOE Office Websites (Extended Search)

Tech Team Tech Team Oak Ridge National Laboratory January, 2005 Team Members * Tony Bouza: DOE * Nick Burkhead: SC * Dan Casey: CVX * Maria Curry- Nkansah: BP* * Jim Kegerreis: XOM * George Parks: COP** * Mark Paster: DOE** * Steve Pawel: ORNL * Jim Simnick: BP * FOG Liaison ** Co-Leads Shawna McQueen (Energetics): Facilitator Mission * Provide a forum for the Partnership to help advance research aimed at developing low cost, safe, and energy efficient hydrogen delivery systems * Catalyze the development of hydrogen delivery technologies that enable the introduction and long-term viability of hydrogen as an energy carrier for transportation and stationary power Useful Facts * 1 kg H 2 = 1 gallon gasoline * Eff FCV = 2-3 x Eff ICEV = 1.2-1.4 x Eff HEV * Energy Density - 10,000 psi H 2 = 1.3 kWhr/l

100

Office of Electricity Delivery  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Electricity Delivery Electricity Delivery and Energy Reliability Smart Grid R&D Program DOE Microgrid Workshop Report August 30-31, 2011 San Diego, California ii Acknowledgment The U.S. Department of Energy (DOE) would like to acknowledge the support provided by the organizations represented on the workshop planning committee in developing the workshop process and sessions. The preparation of this workshop report was coordinated by Energy & Environmental Resources Group, LLC (E2RG). The report content is based on the workshop session discussions, with session summary descriptions taken from the report-out presentations by individual teams during the closing plenary. Contributions to this report by all workshop participants, via expressed viewpoints during the

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Hydrogen Delivery Infrastructure Option Analysis  

NLE Websites -- All DOE Office Websites (Extended Search)

Hydrogen Delivery Infrastructure Hydrogen Delivery Infrastructure Option Analysis Option Analysis DOE and FreedomCAR & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop January 25, 2005 Washington DC This presentation does not contain any proprietary or confidential information Tan-Ping Chen Nexant Jim Campbell Bhadra Grover Air Liquide Stefan Unnasch TIAX Glyn Hazelden GTI Graham Moore Chevron Matt Ringer NREL Ray Hobbs Pinnacle West 2 Presentation Outline Project Background Knowledge Collected and Preliminary Results for Each Delivery Option Summary of Observations Next Step Project Background Project Background 4 Delivery Options Option 1* GH delivery by new pipelines Option 2 Converting NG/oil pipelines for GH delivery Option 3 Blending GH into NG pipelines Option 4* GH tube trailers

102

Magnetically-triggered Nanocomposite Membranes: a Versatile Platform for Triggered Drug Release  

E-Print Network (OSTI)

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. The dose of drug delivered can be tuned by engineering the phase transition temperature of the nanogel, the loading of nanogels in the membrane, and the membrane thickness, allowing for the delivery of drugs over several orders of magnitude of release rates. The zero-order kinetics of drug release through the membranes permit drug doses from a specific device to be tuned according to the duration of the magnetic field. Drugs over a broad range of molecular weights (500-40,000 Da) can be delivered by the same membrane device. Membrane-to-membrane and cycle-to-cycle reproducibility is demonstrated, suggesting the general utility of these membranes for drug delivery.

Todd Hoare; Brian P. Timko; Jesus Santamaria; Gerardo F. Goya; Silvia Irusta; Debora Lin; Samantha Lau; Robert Langer; Daniel S. Kohane

2011-06-27T23:59:59.000Z

103

FCT Hydrogen Delivery: Current Technology  

NLE Websites -- All DOE Office Websites (Extended Search)

Current Technology to someone Current Technology to someone by E-mail Share FCT Hydrogen Delivery: Current Technology on Facebook Tweet about FCT Hydrogen Delivery: Current Technology on Twitter Bookmark FCT Hydrogen Delivery: Current Technology on Google Bookmark FCT Hydrogen Delivery: Current Technology on Delicious Rank FCT Hydrogen Delivery: Current Technology on Digg Find More places to share FCT Hydrogen Delivery: Current Technology on AddThis.com... Home Basics Current Technology R&D Activities Quick Links Hydrogen Production Hydrogen Storage Fuel Cells Technology Validation Manufacturing Codes & Standards Education Systems Analysis Contacts Current Technology Today, hydrogen is transported from the point of production to the point of use via pipeline, over the road in cryogenic liquid trucks or gaseous tube

104

Exploring Polymer and Liposomal Carriers for Optimized Drug Delivery  

E-Print Network (OSTI)

N N N O O O N N N N N K 2 P tCl 4 , ac etone, w ater , 65 oO O O O B ( OH) 2 O K 2 P tCl 4 , a c eto ne, water , 65 o C

Ferguson, Heidi M

2012-01-01T23:59:59.000Z

105

next-generation metrology for drug delivery systems  

Science Conference Proceedings (OSTI)

... With the application of cluster primary ion sources, such as C60+, C8-, Au3+, SF5+ and more recently Bi3+, one typically achieves significant ...

2012-10-02T23:59:59.000Z

106

TIGER -- A technology to improve the delivery capability of nuclear bombs and the survivability of the delivery aircraft  

SciTech Connect

The TIGER (Terminal guided and Extended-Range) Program was initiated in 1972 to study improved delivery capabilities for stockpiled tactical nuclear bombs. The Southeast Asia conflict fostered the development of air-delivered standoff conventional weapons utilizing terminal guidance systems. SNL initiated the TIGER program to determine if current nuclear bombs could be provided with a similarly accurate standoff capabilities. These conventional weapon delivery techniques, while allowing highly accurate attack, generally require entering the target area at high altitude to establish line of sight to the target. In parallel with the TIGER program, system studies analyzed this concept and showed marked improvement in aircraft and weapon survivability with moderate standoff (10--20 km) if low level deliveries (60 m) could be accomplished. As a result of this work, the TIGER program was redirected in early 1974 to demonstrate a standoff bomb with good accuracy (90 m CEP) when delivered from low flying aircraft. This program redirection resulted in the selection of an inertial guidance system to replace the earlier terminal guidance systems. This program was called the Extended-Range Bomb (ERB). In May 1974, a joint Air Force/DOE study identified the desirability of having a single tactical weapon which could be employed against either fixed, preselected targets, or mobile battlefield targets. Studies conducted on the ERB system showed that the inertially guided weapon could fly not only the standoff mission but also a return-to-target mission against the mobile battlefield targets whose locations are not known accurately enough to use a standoff delivery. The ERB program evolved from these initial investigations into an exploratory program to develop the hardware and demonstrate the technology required to fly standoff and return-to-target trajectories. The application of this technology in the form of field retrofit kits to the B61 bomb is called TIGER II.

1980-12-31T23:59:59.000Z

107

Electricity Delivery and Energy Reliability | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Electricity Delivery and Energy Reliability Electricity Delivery and Energy Reliability information about the delivery of electricity and energy reliability Electricity Delivery...

108

Secondary fuel delivery system  

SciTech Connect

A secondary fuel delivery system for delivering a secondary stream of fuel and/or diluent to a secondary combustion zone located in the transition piece of a combustion engine, downstream of the engine primary combustion region is disclosed. The system includes a manifold formed integral to, and surrounding a portion of, the transition piece, a manifold inlet port, and a collection of injection nozzles. A flowsleeve augments fuel/diluent flow velocity and improves the system cooling effectiveness. Passive cooling elements, including effusion cooling holes located within the transition boundary and thermal-stress-dissipating gaps that resist thermal stress accumulation, provide supplemental heat dissipation in key areas. The system delivers a secondary fuel/diluent mixture to a secondary combustion zone located along the length of the transition piece, while reducing the impact of elevated vibration levels found within the transition piece and avoiding the heat dissipation difficulties often associated with traditional vibration reduction methods.

Parker, David M. (Oviedo, FL); Cai, Weidong (Oviedo, FL); Garan, Daniel W. (Orlando, FL); Harris, Arthur J. (Orlando, FL)

2010-02-23T23:59:59.000Z

109

Hydrogen Delivery Analysis Plus Meeting  

E-Print Network (OSTI)

Advanced Distinct ConventionalConventionalConventional Gasification Coal Gasif w/CO2 SeqCoal Gasification w/CO2 SequestrationGasification #12;Note: All cases include assessment of current, mid-term, and long · Estimates the cost of H2 delivery ($/kg) · Assumes 2005 delivery technologies · We can insert our Research

110

Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery  

Science Conference Proceedings (OSTI)

The bimodal mesoporous silica modified with 3-aminopropyltriethoxysilane was performed as the aspirin carrier. The samples' structure, drug loading and release profiles were characterized with X-ray diffraction, scanning electron microscopy, N{sub 2} adsorption and desorption, Fourier transform infrared spectroscopy, TG analysis, elemental analysis and UV-spectrophotometer. For further exploring the effects of the bimodal mesopores on the drug delivery behavior, the unimodal mesoporous material MCM-41 was also modified as the aspirin carrier. Meantime, Korsmeyer-Peppas equation f{sub t}=kt{sup n} was employed to analyze the dissolution data in details. It is indicated that the bimodal mesopores are beneficial for unrestricted drug molecules diffusing and therefore lead to a higher loading and faster releasing than that of MCM-41. The results show that the aspirin delivery properties are influenced considerably by the mesoporous matrix, whereas the large pore of bimodal mesoporous silica is the key point for the improved controlled-release properties. - Graphical abstract: Loading (A) and release profiles (B) of aspirin in N-BMMs and N-MCM-41 indicated that BMMs have more drug loading capacity and faster release rate than that MCM-41. Highlights: > Bimodal mesoporous silicas (BMMs) and MCM-41 modified with amino group via post-treatment procedure. > Loading and release profiles of aspirin in modified BMMs and MCM-41. > Modified BMMs have more drug loading capacity and faster release rate than that modified MCM-41.

Gao Lin [Department of Chemistry and Chemical Engineering, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124 (China); Sun Jihong, E-mail: jhsun@bjut.edu.cn [Department of Chemistry and Chemical Engineering, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124 (China); Li Yuzhen [Department of Chemistry and Chemical Engineering, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124 (China)

2011-08-15T23:59:59.000Z

111

Hydrogen Production and Delivery Research  

DOE Green Energy (OSTI)

In response to DOE's Solicitation for Grant Applications DE-PS36-03GO93007, 'Hydrogen Production and Delivery Research', SRI International (SRI) proposed to conduct work under Technical Topic Area 5, Advanced Electrolysis Systems; Sub-Topic 5B, High-Temperature Steam Electrolysis. We proposed to develop a prototype of a modular industrial system for low-cost generation of H{sub 2} (<$2/kg) by steam electrolysis with anodic depolarization by CO. Water will be decomposed electrochemically into H{sub 2} and O{sub 2} on the cathode side of a high-temperature electrolyzer. Oxygen ions will migrate through an oxygen-ion-conductive solid oxide electrolyte. Gas mixtures on the cathode side (H{sub 2} + H{sub 2}O) and on the anode side (CO + CO{sub 2}) will be reliably separated by the solid electrolyte. Depolarization of the anodic process will decrease the electrolysis voltage, and thus the electricity required for H{sub 2} generation and the cost of produced H{sub 2}. The process is expected to be at least 10 times more energy-efficient than low-temperature electrolysis and will generate H{sub 2} at a cost of approximately $1-$1.5/kg. The operating economics of the system can be made even more attractive by deploying it at locations where waste heat is available; using waste heat would reduce the electricity required for heating the system. Two critical targets must be achieved: an H{sub 2} production cost below $2/kg, and scalable design of the pilot H{sub 2} generation system. The project deliverables would be (1) a pilot electrolysis system for H{sub 2} generation, (2) an economic analysis, (3) a market analysis, and (4) recommendations and technical documentation for field deployment. DOE was able to provide only 200K out of 1.8M (or about 10% of awarded budget), so project was stopped abruptly.

Iouri Balachov, PhD

2007-10-15T23:59:59.000Z

112

H2A Delivery Models and Results  

NLE Websites -- All DOE Office Websites (Extended Search)

of well defined "base cases" that span major markets and demand levels: Hydrogen Delivery Scenario Analysis Model (HDSAM) * Estimate the cost of H 2 delivery for base cases. *...

113

National Electric Delivery Technologies Roadmap: Transforming...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Delivery Technologies Roadmap: Transforming the Grid to Revolutionize Electric Power in North America National Electric Delivery Technologies Roadmap: Transforming the Grid to...

114

Available Technologies: Non-catalytic Domain Targets in MMPs ...  

Biofuels; Biotechnology & Medicine. Diagnostics and Therapeutics; Medical Devices; ... might be the correct target for drugs that would block tumor growth or metastases.

115

Hydrogen Delivery Infrastructure Options Analysis  

Fuel Cell Technologies Publication and Product Library (EERE)

This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

116

Hydrogen Storage Technologies Hydrogen Delivery  

E-Print Network (OSTI)

Hydrogen Storage Technologies Roadmap Hydrogen Delivery Technical Team Roadmap June 2013 #12;This.................................................................................. 13 6. Hydrogen Storage and Innovation for Vehicle efficiency and Energy sustainability) is a voluntary, nonbinding, and nonlegal

117

Hydrogen Distribution and Delivery Infrastructure  

Fuel Cell Technologies Publication and Product Library (EERE)

This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

118

Radiation delivery system and method  

DOE Patents (OSTI)

A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

Sorensen, Scott A. (Overland Park, KS); Robison, Thomas W. (Los Alamos, NM); Taylor, Craig M. V. (Jemez Springs, NM)

2002-01-01T23:59:59.000Z

119

Hydrogen Delivery Technology Roadmap, November 2005  

Fuel Cell Technologies Publication and Product Library (EERE)

Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

120

Sustained delivery of bioactive TGF-?1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells  

E-Print Network (OSTI)

Tissue engineering strategies for cartilage defect repair require technology for local targeted delivery of chondrogenic and anti-inflammatory factors. The objective of this study was to determine the release kinetics of ...

Kopesky, Paul Wayne

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

DOE Hydrogen and Fuel Cells Program Record 13013: Hydrogen Delivery Cost Projections - 2013  

NLE Websites -- All DOE Office Websites (Extended Search)

3013 Date: September 26, 2013 3013 Date: September 26, 2013 Title: H 2 Delivery Cost Projections - 2013 Originator: E. Sutherland, A. Elgowainy and S. Dillich Approved by: R. Farmer and S. Satyapal Date: December 18, 2013 Item: Reported herein are past 2005 and 2011 estimates, current 2013 estimates, 2020 projected cost estimates and the 2015 and 2020 target costs for delivering and dispensing (untaxed) H 2 to 10%- 15% of vehicles within a city population of 1.2M from a centralized H 2 production plant located 100 km from the city gate. The 2011 volume cost estimates are based on the H2A Hydrogen Delivery Scenario Analysis Model (HDSAM) V2.3 projections and are employed as the basis for defining the cost and technical targets of delivery components in Table 3.2.4 in the 2012 Delivery

122

Hydrogen Delivery Options and Issues  

NLE Websites -- All DOE Office Websites (Extended Search)

Options and Issues Options and Issues Mark Paster DOE August, 2006 Scope * From the end point of central or distributed production (300 psi H2) to and including the dispenser at a refueling station or stationary power site - GH2 Pipelines and Trucks, LH2 Trucks, Carriers <$1.00/kg of Hydrogen by 2017 Hydrogen Delivery H2 Delivery Current Status * Technology - GH2 Tube Trailers: ~340 kg, ~2600 psi - LH2 Trucks: ~3900 kg - Pipelines: up to 1500 psi (~630 miles in the U.S.) - Refueling Site Operations (compression, storage dispensing): Demonstration projects * Cost (Does NOT include refueling Site Operations) - Trucks: $4-$12/kg - Pipeline: <$2/kg H2A Analysis * Consistent, comparable, transparent approach to hydrogen production and delivery cost analysis * Excel spreadsheet tools with common economic

123

Hydrogen Delivery Model for H2A Analysis: A Spreadsheet Model For Hydrogen Delivery Scenarios  

E-Print Network (OSTI)

FINAL REPORT HYDROGEN DELIVERY MODEL FOR H2AA SPREADSHEET MODEL FOR HYDROGEN DELIVERY SCENARIOS Joan M.Department of Energy Hydrogen, Fuel Cells and Infrastructure

Ogden, Joan

2004-01-01T23:59:59.000Z

124

Hydrogen Delivery Model for H2A Analysis: A Spreadsheet Model for Hydrogen Delivery Scenarios  

E-Print Network (OSTI)

FINAL REPORT HYDROGEN DELIVERY MODEL FOR H2AA SPREADSHEET MODEL FOR HYDROGEN DELIVERY SCENARIOS Joan M.Department of Energy Hydrogen, Fuel Cells and Infrastructure

Ogden, Joan M

2004-01-01T23:59:59.000Z

125

Comments of Oncor Electric Delivery Company LLC | Department...  

NLE Websites -- All DOE Office Websites (Extended Search)

Oncor Electric Delivery Company LLC Comments of Oncor Electric Delivery Company LLC Comments of Oncor Electric Delivery Company LLC on Implementing the National Broadband Plan by...

126

Electricity Delivery and Energy Reliability  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

The Office of Electricity Delivery and Energy Reliability (OE) drives electric grid modernization and resiliency in the energy infrastructure while working to enable innovation across the energy sector, empowering American consumers, and securing our energy future. The OE mission and the leadership role OE plays in the energy industry directly support the President's effort to accelerate the transformation of America's energy system

127

California Natural Gas International Deliveries (Million Cubic...  

U.S. Energy Information Administration (EIA) Indexed Site

Deliveries (Million Cubic Feet) California Natural Gas International Deliveries (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

128

Bugs, Drugs & Smoke  

E-Print Network (OSTI)

burden of drug-resistant TB, including four – China, India,on drug-resistant TB organized by WHO in Beijing, China, inChina, the Democratic Republic of the Congo, Estonia, Ethiopia, Georgia, India, Indonesia, in new drug-

WHO

2012-01-01T23:59:59.000Z

129

Accelerator target  

DOE Patents (OSTI)

A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

Schlyer, David J. (Bellport, NY); Ferrieri, Richard A. (Patchogue, NY); Koehler, Conrad (Miller Place, NY)

1999-01-01T23:59:59.000Z

130

Accelerator target  

DOE Patents (OSTI)

A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

1999-06-29T23:59:59.000Z

131

Machine and Beam Delivery Updates  

NLE Websites -- All DOE Office Websites (Extended Search)

MAchine and Beam delivery Updates FY13 MAchine and Beam delivery Updates FY13 Summary of Beam Delivery: FACET Summary Feb_15_22.pdf FACET Summary Feb_15_22.pdf FACET Summary Feb_23_Mar_1.pdf FACET Summary Feb_23_Mar_1.pdf FACET Summary Mar_2_8.pdf FACET Summary Mar_2_8.pdf FACET Summary Mar_9_15.pdf FACET Summary Mar_9_15.pdf FACET Summary Mar_16_22.pdf FACET Summary Mar_16_22.pdf FACET Summary Mar_23_29.pdf FACET Summary Mar_23_29.pdf FACET Summary Mar_30_Apr_5.pdf FACET Summary Mar_30_Apr_5.pdf FACET Summary Apr_6_12.pdf FACET Summary Apr_6_12.pdf FACET Summary Apr_27_May_3.pdf FACET Summary Apr_27_May_3.pdf FACET Summary May_4_10.pdf FACET Summary May_4_10.pdf Emittance Stability in Sector 2_31513.pdf Emittance Stability in Sector 2_31513.pdf FACET beam operations readiness with R56.pdf FACET beam operations readiness with R56.pdf (6/19/2013)

132

Fast Arc Delivery for Stereotactic Body Radiotherapy of Vertebral and Lung Tumors  

SciTech Connect

Purpose: Flattening filter-free (FFF) beams with higher dose rates and faster delivery are now clinically available. The purpose of this planning study was to compare optimized non-FFF and FFF RapidArc plans for stereotactic body radiotherapy (SBRT) and to validate the accuracy of fast arc delivery. Methods and Material: Ten patients with peripheral lung tumors and 10 with vertebral metastases were planned using RapidArc with a flattened 6-MV photon beam and a 10-MV FFF beam for fraction doses of 7.5-18 Gy. Dosimetry of the target and organs at risk (OAR), number of monitor units (MU), and beam delivery times were assessed. GafChromic EBT2 film measurements of FFF plans were performed to compare calculated and delivered dose distributions. Results: No major dosimetric differences were seen between the two delivery techniques. For lung SBRT plans, conformity indices and OAR doses were similar, although the average MU required were higher with FFF plans. For vertebral SBRT, FFF plans provided comparable PTV coverage, with no significant differences in OAR doses. Average beam delivery times were reduced by a factor of up to 2.5, with all FFF fractions deliverable within 4 min. Measured FFF plans showed high agreement with calculated plans, with more than 99% of the area within the region of interest fulfilling the acceptance criterion. Conclusion: The higher dose rate of FFF RapidArc reduces delivery times significantly, without compromising plan quality or accuracy of dose delivery.

Ong, Chin Loon, E-mail: c.ong@vumc.nl [Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands); Verbakel, Wilko F.A.R.; Dahele, Max; Cuijpers, Johan P.; Slotman, Ben J.; Senan, Suresh [Department of Radiation Oncology, VU University Medical Center, Amsterdam (Netherlands)

2012-05-01T23:59:59.000Z

133

Fully monolithic cellular buck converter design for 3-D power delivery  

E-Print Network (OSTI)

A fully monolithic interleaved buck dc-dc point-of-load (PoL) converter has been designed and fabricated in a 0.18-mm SiGe BiCMOS process. Target application of the design is 3-D power delivery for future microprocessors, ...

Sun, Jian

134

Fiber coupled optical spark delivery system  

DOE Patents (OSTI)

A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO)

2008-08-12T23:59:59.000Z

135

The Fate of MAb targeted Cd125mTe/ZnS nanoparaticles in vivo  

Science Conference Proceedings (OSTI)

Nanoparticles (NP) have potential as carriers for drugs and radioisotopes. Quantitative measures of NP biodistribution in vivo are needed to determine the effectiveness of these carriers. We have used a model system of radiolabeled quantum dots to document the competition between efficient vascular targeting and interaction of the NP with the reticuloendothelial (RE) system. We have prepared (125m)Te-labeled CdTe NP that are capped with ZnS. Te-125m has a half-life and decay characteristics very similar to those for (125)I. The synthesized particles are stable in aqueous solution and are derivatized with mercaptoacetic acid and then conjugated with specific antibody. To evaluate specific targeting, we used the monoclonal antibody MAb 201B that binds to murine thrombomodulin expressed in the lumen of lung blood vessels. The MAb-targeted NP were tested for targeting performance in vivo using single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging, tissue autoradiography and standard organ biodistribution techniques. Biodistribution was also determined in mice that had been depleted of phagocytic cells by use of clodronate-loaded liposomes. Cd(125m)Te/ZnS NP coupled with MAb 201B retained radioisotope and antibody activity and accumulated in lung (>400% injected dose [ID]/g) within 1 h of intravenous injection. Control antibody-coupled NP did not accumulate in lung (<10% ID/g) but accumulated in liver and spleen. Images from microSPECT/CT and autoradiography studies of the targeted NP document this specific uptake and demonstrate uniform distribution in lung with minor accumulation in liver and spleen. Within a few hours, a large fraction of lung-targeted NP redistributed to spleen and liver or was excreted. We hypothesized that NP attract phagocytic cells that engulfed and removed them from circulation. This was confirmed by comparing biodistribution of targeted NP in normal mice versus those depleted of phagocytic cells. In mice treated with clodronate liposomes, accumulation of NP in liver was reduced by fivefold, while accumulation in lung at 1 h was enhanced by approximately 50%. By 24 h, loss of the targeted NP from lung was inhibited by several-fold, while accumulation in liver and spleen remained constant. Thus, the treated mice had a much larger accumulation and retention of the NP at the target site and a decrease in dose to other organs except spleen. Nanoparticles composed of CdTe, labeled with (125m)Te and capped with ZnS, can be targeted with MAb to sites in the lumen of lung vasculature. In clodronate-treated mice, which have a temporary depletion of phagocytic cells, accumulation in liver was reduced dramatically, whereas that in spleen was not. The targeting to lung was several-fold more efficient in clodronate-treated mice due to larger initial accumulation and better retention of the MAb-targeted NP at that site. This model system indicates that targeting of NP preparations is a competition between the effectiveness of the targeting agent and the natural tendency for RE uptake of the particles. Temporary inhibition of the RE system may enhance the usefulness of NP for drug and radioisotope delivery.

Kennel, Steve J [ORNL; Woodward, Jonathan [ORNL; Rondinone, Adam Justin [ORNL; Wall, Jonathan [ORNL; Mirzadeh, Saed [ORNL

2008-01-01T23:59:59.000Z

136

Office of Electricity Delivery and Energy Reliability  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Department of Energy in Response to Request for Information: Addressing Policy and Logistical...

137

Nano-vesicles for gene delivery.  

E-Print Network (OSTI)

??Gene therapy was considered an important modality for the potential treatment of cancer. It aimed to correct diseases through the delivery of genetic material encoding… (more)

Tan, Karen Li Ping.

2008-01-01T23:59:59.000Z

138

Categorical Exclusion Determinations: Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

October 18, 2010 CX-004242: Categorical Exclusion Determination Colonias for Microgrids (Texas) Office of Electricity Delivery and Energy Reliability 14.09 CX(s) Applied:...

139

Categorical Exclusion Determinations: Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Laboratory July 23, 2010 CX-003171: Categorical Exclusion Determination Colonias for Microgrids (Texas) Electricity Delivery and Energy Reliability (OE) 14.09 CX(s) Applied: A1,...

140

Categorical Exclusion Determinations: Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Planning and Priorities CX(s) Applied: A9, A11 Date: 04222010 Location(s): Denver, Colorado Office(s): Electricity Delivery and Energy Reliability, National Energy...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Delivery of Hydrogen Produced from Natural Gas  

NLE Websites -- All DOE Office Websites (Extended Search)

Identify and evaluate the most promising approaches and options for economic storage, handling and delivery of hydrogen. Office of Fossil Energy Milestone * 2006: Define a...

142

Vulnerability Analysis of Energy Delivery Control Systems  

Energy.gov (U.S. Department of Energy (DOE))

The Vulnerability Analysis of Energy Delivery Control Systems report, prepared by Idaho National Laboratory, describes the common vulnerabilities on energy sector control systems, and provides...

143

Laser Beam Delivery [Laser Applications Laboratory] - Nuclear...  

NLE Websites -- All DOE Office Websites (Extended Search)

Laser Glazing of Railroad Rails High Power Laser Beam Delivery Decontamination and Decommissioning Refractory Alloy Welding Robots Applications Other Facilities Other Capabilities...

144

Roadmap to Achieve Energy Delivery Systems Cybersecurity  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Roadmap to Achieve Energy Delivery Systems Cybersecurity ii Acknowledgements The Energy Sector Control Systems Working Group (ESCSWG) developed this roadmap in support of the...

145

Mercury Sorbent Delivery System for Flue Gas  

NLE Websites -- All DOE Office Websites (Extended Search)

(NETL) is seeking licensing partners interested in implementing United States Patent Number 7,494,632 entitled "Mercury Sorbent Delivery System for Flue Gas." Disclosed in...

146

Nanolipoprotein Particles for Vaccine and Adjuvant Delivery  

home \\ technologies \\ nlps for vaccines. Technologies: Ready-to-Sign Licenses: Software: Patents: Nanolipoprotein Particles for Vaccine and Adjuvant Delivery. Contact.

147

Light Sources Help Discover New Drug Against Melanoma | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma Light Sources Help Discover New Drug Against Melanoma July 18, 2011 - 12:07pm Addthis The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. The new anti-cancer drug, vemurafenib, is the green honeycomb structure at middle left. Four dotted red lines show where it attaches to a target area in the mutated enzyme, disabling it from promoting the growth of tumors. | Image courtesy of Plexxikon Inc. Mike Ross Science Writer at SLAC National Accelerator Laboratory What does this mean for me? A new drug designed to fight melanoma was discovered thanks to the

148

Polarized hydrogen gas target. Closeout report  

DOE Green Energy (OSTI)

The purpose of the equipment was to produce a polarized gas target for use as an internal target in storage rings. The part funded under this grant was the construction of the atomic-beam apparatus. In addition to the $300,000 award, $13,267 from DOE operating funds and $19,700 provided by the University was spent on the construction of the atomic beam apparatus. Certain other parts required for the experiments, like the target cell, the target vacuum chamber, and the detectors, were funded by the University of Wisconsin. The cost for installation of the target in the cooler ring at the Indiana University Cyclotron Facility was $2,400. The equipment became operational for the first time in August 1992, after the sixpole magnets, the delivery of which was delayed by more than 6 months because of manufacturing problems, were delivered. There followed a period of measurements to optimize the atomic-beam intensity. In 1992, further work was done using other sources of funds to augment the performance of the polarized gas target by means of radiofrequency (RF) transitions intended to double the degree of polarization of the target. Immediately after the above tests, the polarized gas target equipment was shipped to Bloomington, Indiana where installation in the proton storage ring was completed in July 1993.

NONE

1994-12-31T23:59:59.000Z

149

How molecular imaging is speeding up antiangiogenic drug development  

E-Print Network (OSTI)

How molecular imaging is speeding up antiangiogenic drug development Weibo Cai,1 Jianghong Rao,1 Sanjiv S. Gambhir,1,2 and Xiaoyuan Chen1 1 The Molecular Imaging Program at Stanford, Department. The shift in recent drug discovery to novel agents against specific molecular targets high- lights the need

Rao, Jianghong

150

Bulk Hydrogen Storage - Strategic Directions for Hydrogen Delivery Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Hydrogen Hydrogen Storage Strategic Directions for Hydrogen Delivery Workshop May 7-8, 2003 Crystal City, Virginia Breakout Session - Bulk Hydrogen Storage Main Themes/Caveats Bulk Storage = Anything not on the vehicle 10's of Tons -- End use point 50-100 Tons - Terminals/City Gates 1000's Tons - Between Production Facility and Terminal/City Gate Bulk storage requirements less restrictive and different from on-board storage Uncertainty about evolution of infrastructure requires multiple pathways to be considered Bulk storage is an economic solution to address supply/demand imbalance Breakout Session - Bulk Hydrogen Storage Targets/Objectives Hard to quantify - scenario & end-use dependent Storage Materials (solid state) and container require different targets

151

Third Power Delivery Asset Management Conference Proceedings  

Science Conference Proceedings (OSTI)

Today's utility managers face an array of conflicting business objectives. In response, many utilities are considering implementing asset management concepts. The Third EPRI Power Delivery Asset Management Conference highlighted the work of researchers, consultants, software providers, and utilities in identifying and overcoming challenges faced in implementing asset management programs for transmission, distribution, and independent system operator (ISO) business segments of power delivery.

2007-03-29T23:59:59.000Z

152

Fifth Power Delivery Asset Management Conference  

Science Conference Proceedings (OSTI)

The Electric Power Research (EPRI) Asset Management Conference is part of EPRI's Power Delivery Asset Management program. The Asset Management Conference helps members manage their corporate culture by incorporating asset management best practices and aligning organizational processes around asset management goals. This report details EPRI's fifth Power Delivery Asset Management (PDAM) Conference.

2011-11-29T23:59:59.000Z

153

Delivery of Hydrogen Produced from Natural Gas  

E-Print Network (OSTI)

for economic storage, handling and delivery of hydrogen. Office of Fossil Energy Milestone · 2006: Define & Petroleum Technology Office of Fossil Energy June 3, 2003 Hydrogen Coordination Meeting #12;Key NearDelivery of Hydrogen Produced from Natural Gas Christopher Freitas Office of Natural Gas

154

Potential Carriers and Approaches for Hydrogen Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Carriers and Potential Carriers and Carriers and Potential Carriers and Approaches for Hydrogen Approaches for Hydrogen Delivery Delivery TIAX LLC 1601 S. D Anza Blvd. Cupertino CA, 95014 Tel. 408-517-1550 Reference: D0348 © 2007 TIAX LLC Hydrogen Delivery Analysis Meeting May 8-9, 2007 Columbia, Maryland Matthew Hooks Stefan Unnasch Stephen Lasher 1 Novel Hydrogen Carriers Project Overview Cost Density (wt. and vol.) Energy requirements Forecourt storage requirements Codes and standards H H 2 2 Plant, Liquefier, LH Plant, Liquefier, LH 2 2 storage storage H H 2 2 Tube Trailer Tube Trailer LH 2 2 Tank/ Fueling Station LH Tank/ Fueling Station The efficient delivery of hydrogen is necessary for the adoption of hydrogen as a transportation fuel, but numerous challenges must be met. 2 "Conventional" delivery options are limited by volumetric density,

155

Fiber laser coupled optical spark delivery system  

DOE Patents (OSTI)

A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

2008-03-04T23:59:59.000Z

156

Life-Changing Drug Design  

NLE Websites -- All DOE Office Websites (Extended Search)

facilities are aimed at designing more effective drugs with fewer side effects. Life-Changing Drug Design One notable example is vemurafenib, a drug designed by...

157

Tissue-Specific Gene Delivery via Nanoparticle Coating  

E-Print Network (OSTI)

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

Harris, Todd J.

158

The delivery option in mortgage backed security valuation simulations  

Science Conference Proceedings (OSTI)

A delivery option exists in mortgage-backed security market, which has not been considered in existing mortgage pricing simulation literature. We explain the delivery option in the "To Be Announced" trade. We discuss how the presence of the delivery ...

Scott Gregory Chastain; Jian Chen

2005-12-01T23:59:59.000Z

159

A key target for diabetes drugs | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

and Systems (AIMMS) of VU University Amsterdam; and Jesper Lau at Novo Nordisk (Denmark). Combining the new data with previous work, computational biochemists De Graaf and...

160

Gastric H,K-ATPase as a drug target  

E-Print Network (OSTI)

cations. J Biol Chem Fukushima Y, Nakao M: Changes inChem 1980;255(16):7813-9. Fukushima Y, Post RL: Binding of

Shin, Jai M; Sachs, G

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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161

Percentage of Total Natural Gas Residential Deliveries included...  

Gasoline and Diesel Fuel Update (EIA)

City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices...

162

Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery and Delivery and Fueling (Text Alternative Version) to someone by E-mail Share Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Facebook Tweet about Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Twitter Bookmark Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Google Bookmark Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Delicious Rank Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on Digg Find More places to share Fuel Cell Technologies Office: Hydrogen Delivery and Fueling (Text Alternative Version) on AddThis.com... Publications Program Publications

163

California Natural Gas Exports (No Intransit Deliveries) (Million...  

Annual Energy Outlook 2012 (EIA)

Exports (No Intransit Deliveries) (Million Cubic Feet) California Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4...

164

Office of Electricity Delivery & Energy Reliability FY 2012 Budget...  

NLE Websites -- All DOE Office Websites (Extended Search)

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation...

165

Office of Electricity Delivery And Energy Reliability To Hold...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy...

166

Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...  

NLE Websites -- All DOE Office Websites (Extended Search)

on Hydrogen Delivery Modeling and Analysis FreedomCAR and Fuels Partnership Hydrogen Delivery, Storage and Fuel Pathway Integration Tech Teams May 8-9, 2007 Energetics...

167

FY 2014 Budget Request for the Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Budget Request for the Office of Electricity Delivery and Energy Reliability FY 2014 Budget Request for the Office of Electricity Delivery and Energy Reliability Table showing the...

168

FY 2013 Budget Request for the Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

3 Budget Request for the Office of Electricity Delivery and Energy Reliability FY 2013 Budget Request for the Office of Electricity Delivery and Energy Reliability Table showing...

169

Texas Natural Gas Deliveries to Electric Power Consumers (Million...  

U.S. Energy Information Administration (EIA) Indexed Site

View History: Monthly Annual Download Data (XLS File) Texas Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Texas Natural Gas Deliveries to Electric Power...

170

Secretary of Energy Announces New Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

of Electricity Delivery & Energy Reliability Secretary of Energy Announces New Office of Electricity Delivery & Energy Reliability June 9, 2005 - 1:45pm Addthis WASHINGTON, DC --...

171

Office of Electricity Delivery and Energy Reliability: Organizational...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Skip to main content Energy.gov Office of Electricity Delivery & Energy Reliability Search form Search Office of Electricity Delivery & Energy Reliability Services Electricity...

172

Office of Electricity Delivery & Energy Reliability 2010 Strategic...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

You are here Home Office of Electricity Delivery & Energy Reliability 2010 Strategic Plan (WEB) Office of Electricity Delivery & Energy Reliability 2010 Strategic Plan...

173

Office of Electricity and Delivery & Energy Reliability 2010...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

You are here Home Office of Electricity and Delivery & Energy Reliability 2010 Strategic Plan (PRINT) Office of Electricity and Delivery & Energy Reliability 2010 Strategic...

174

2013 Annual Planning Summary for the Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Electricity Delivery and Energy Reliability 2013 Annual Planning Summary for the Office of Electricity Delivery and Energy Reliability 2013 Annual Planning Summary for the Carlsbad...

175

Natural Gas Deliveries to Commercial Consumers (Including Vehicle...  

Gasoline and Diesel Fuel Update (EIA)

Natural Gas Deliveries to Commercial Consumers (Including Vehicle Fuel through 1996) in South Dakota (Million Cubic Feet) Natural Gas Deliveries to Commercial Consumers...

176

South Dakota Natural Gas % of Total Residential Deliveries (Percent...  

Gasoline and Diesel Fuel Update (EIA)

View History: Annual Download Data (XLS File) South Dakota Natural Gas % of Total Residential Deliveries (Percent) South Dakota Natural Gas % of Total Residential Deliveries...

177

South Dakota Natural Gas Deliveries to Electric Power Consumers...  

Annual Energy Outlook 2012 (EIA)

View History: Monthly Annual Download Data (XLS File) South Dakota Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) South Dakota Natural Gas Deliveries to...

178

Target tracking using DMLC for volumetric modulated arc therapy: A simulation study  

SciTech Connect

Purpose: Target tracking using dynamic multileaf collimator (DMLC) is a promising approach for intrafraction motion management in radiation therapy. The purpose of this work is to develop a DMLC tracking algorithm capable of delivering volumetric-modulated arc therapy (VMAT) to the targets that experience two-dimensional (2D) rigid motion in the beam's eye view. Methods: The problem of VMAT delivery to moving targets is formulated as a control problem with constraints. The relationships between gantry speed, gantry acceleration, MLC leaf-velocity, dose rate, and target motion are derived. An iterative search algorithm is developed to find numerical solutions for efficient delivery of a specific VMAT plan to the moving target using 2D DMLC tracking. The delivery of five VMAT lung plans is simulated. The planned and delivered fluence maps in the target-reference frame are calculated and compared. Results: The simulation demonstrates that the 2D tracking algorithm is capable of delivering the VMAT plan to a moving target fast and accurately without violating the machine constraints and the integrity of the treatment plan. The average delivery time is only 29 s longer than that of no-tracking delivery, 101 versus 72 s, respectively. The fluence maps are normalized to 200 MU and the average root-mean-square error between the desired and the delivered fluence is 2.1 MU, compared to 14.8 MU for no-tracking and 3.6 MU for one-dimensional tracking. Conclusions: A locally optimal MLC tracking algorithm for VMAT delivery is proposed, aiming at shortest delivery time while maintaining treatment plan invariant. The inconsequential increase of treatment time due to DMLC tracking is clinically desirable, which makes VMAT with DMLC tracking attractive in treating moving tumors.

Sun Baozhou; Rangaraj, Dharanipathy; Papiez, Lech; Oddiraju, Swetha; Yang Deshan; Li, H. Harold [Department of Radiation Oncology, School of Medicine, Washington University, 4921 Parkview Place, St. Louis, Missouri 63110 (United States); Department of Radiation Oncology, Southwestern Medical Center, University of Texas, Dallas, Texas 75390 (United States); Department of Radiation Oncology, School of Medicine, Washington University, 4921 Parkview Place, St. Louis, Missouri 63110 (United States)

2010-12-15T23:59:59.000Z

179

Delivery and Receipt | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Delivery and Receipt Delivery and Receipt Delivery and Receipt Delivery and Receipt of Personal Property Acquired by Purchase Card at Headquarters Receiving Items Purchased with the Purchase Card that are Shipped or Delivered by the Vendor All personal property acquired by using the purchase card should generally be delivered to and processed by the receiving office (loading dock). This will ensure inventory control identification, as appropriate and recording in the personal property management records. The following practices and procedures, as set forth by the Personal Property and Supply Management Team, Office of Logistics and Facility Operations, Office of Administration, are effective November 2007. These procedures were implemented to create a safe work environment, reduce

180

Categorical Exclusion Determinations: Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

A9, B3.6, B4.11 Date: 07132010 Location(s): Oak Ridge, Tennessee Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory July 13,...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

NREL: Learning - Energy Delivery and Storage Basics  

NLE Websites -- All DOE Office Websites (Extended Search)

Energy Delivery and Storage Basics Helping secure a clean energy future for the nation and the world isn't just about reducing energy usage or producing clean energy. It is about...

182

Silica-coated liposomes for insulin delivery  

Science Conference Proceedings (OSTI)

Liposomes coated with silica were explored as protein delivery vehicles for their enhanced stability and improved encapsulation efficiency. Insulin was encapsulated within the fluidic phosphatidylcholine lipid vesicles by thin film hydration at pH 2.5, ...

Neelam Dwivedi; M. A. Arunagirinathan; Somesh Sharma; Jayesh Bellare

2010-01-01T23:59:59.000Z

183

Coordinated part delivery using distributed planning  

E-Print Network (OSTI)

In this thesis, we develop a distributed mobile robot platform to deliver parts around a model construction site. The platform's robots, specialized into delivery robots and assembly robots, use a distributed coverage ...

Bolger, Adrienne (Adrienne M.)

2010-01-01T23:59:59.000Z

184

WE?A?BRA?04: Real?Time Telerobotic 3D Ultrasound for Soft?Tissue Guidance Concurrent with Beam Delivery  

Science Conference Proceedings (OSTI)

Managing internal anatomy motion due to physiological random or quasi? periodical processes is a critical challenge in external beam radiation therapy especially in the context of single? or few?fraction ablative regiments for abdominal targets. Existing and emerging technologies for localizing abdominal targets during beam delivery employ tracking of implanted fiducial markers

D Hristov; J Schlosser; C Kirmizibayrak; V Shamdasani; K Salisbury; D Chang; S Metz

2012-01-01T23:59:59.000Z

185

Percent of Industrial Natural Gas Deliveries in Minnesota ...  

U.S. Energy Information Administration (EIA)

Percentage of Total Natural Gas Industrial Deliveries included in Prices ; Minnesota Natural Gas Prices ...

186

Natural Gas Deliveries to Commercial Consumers (Including Vehicle ...  

U.S. Energy Information Administration (EIA)

Natural Gas Deliveries to Commercial Consumers (Including Vehicle Fuel through 1996) in Wisconsin (Million Cubic Feet)

187

TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)  

SciTech Connect

The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition scheme is an essential component of an acceptably low-risk solution. The degree of coupling seen on NIF between driver and target performance mandates that little deviation be adopted from the NIF geometry and beamline characteristics. Similarly, the strong coupling between subsystems in an operational power plant mandates that a self-consistent solution be established via an integrated facility delivery project. The benefits of separability of the subsystems within an IFE plant (driver, chamber, targets, etc.) emerge in the operational phase of a power plant rather than in its developmental phase. An optimized roadmap for IFE delivery needs to account for this to avoid nugatory effort and inconsistent solutions. For LIFE, a system design has been established that could lead to an operating power plant by the mid-2020s, drawing from an integrated subsystem development program to demonstrate the required technology readiness on a time scale compatible with the construction plan. Much technical development work still remains, as does alignment of key stakeholder groups to this newly emerging development option. If the required timeline is to be met, then preparation of a viable program is required alongside the demonstration of ignition on NIF. This will enable timely analysis of the technical and economic case and establishment of the appropriate delivery partnership.

Dunne, A M

2010-11-30T23:59:59.000Z

188

Purchase, Delivery, and Storage of Gases  

NLE Websites -- All DOE Office Websites (Extended Search)

Purchase, Delivery, and Storage of Gases Print Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the ALS. See Shipping and Receiving for information on any non-gas deliveries. Contacts: Gas purchase or delivery: ALS Receiving, 510-486-4494 Gas use and storage: Experiment Coordination, 510-486-7222, This e-mail address is being protected from spambots. You need JavaScript enabled to view it Gas Storage: Berkeley Lab Chemical Inventory All gas bottles and cylinders at the ALS must be identified with bar code and logged into the Berkeley Lab Chemical Inventory by ALS staff. The inventory will be updated periodically; for more information contact Experiment Coordination. Gases are stored either in the racks between buildings 6 and 7; toxic and corrosive gases are stored in Building 6, room 6C across the walkway from beamline 10.0.

189

Magnetically attached sputter targets  

DOE Patents (OSTI)

An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.

Makowiecki, D.M.; McKernan, M.A.

1994-02-15T23:59:59.000Z

190

Structural Biology Helps Drug Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology Helps Drug Discovery Print Last year, drug discovery company Plexxikon made front-page news with its highly successful anti-cancer drug, Zelboraf, a product that...

191

Structural Biology Helps Drug Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology Helps Drug Discovery Structural Biology Helps Drug Discovery Print Thursday, 19 July 2012 11:21 Last year, drug discovery company Plexxikon made front-page news...

192

2012 Revenue for Delivery Service Providers  

U.S. Energy Information Administration (EIA) Indexed Site

Revenue for Delivery Service Providers" Revenue for Delivery Service Providers" "(Data from form EIA-861 schedule 4C)" ,,,"Revenue (Thousands Dollars)" "Entity","State","Ownership","Residential","Commercial","Industrial","Transportation","Total" "Pacific Gas & Electric Co","CA","Investor Owned",38657,306699,232366,2843,580565 "San Diego Gas & Electric Co","CA","Investor Owned",1019.1,62400.1,84143.3,0,147562.5 "Southern California Edison Co","CA","Investor Owned",6706,456007,69193,".",531906 "Connecticut Light & Power Co","CT","Investor Owned",362262,514043,100262,6681,983248

193

Renewable energy delivery systems and methods  

DOE Patents (OSTI)

A system, method and/or apparatus for the delivery of energy at a site, at least a portion of the energy being delivered by at least one or more of a plurality of renewable energy technologies, the system and method including calculating the load required by the site for the period; calculating the amount of renewable energy for the period, including obtaining a capacity and a percentage of the period for the renewable energy to be delivered; comparing the total load to the renewable energy available; and, implementing one or both of additional and alternative renewable energy sources for delivery of energy to the site.

Walker, Howard Andrew

2013-12-10T23:59:59.000Z

194

Targets for Precision Measurements  

E-Print Network (OSTI)

The general properties needed in targets (sources) for high precision, high accuracy measurements are reviewed. The application of these principles to the problem of developing targets for the Fission TPC is described. Longer term issues, such as the availability of actinide materials, improved knowledge of energy losses and straggling and the stability of targets during irradiation are also discussed.

W. Loveland; L. Yao; David M. Asner; R. G. Baker; J. Bundgaard; E. Burgett; M. Cunningham; J. Deaven; D. L. Duke; U. Greife; S. Grimes; M. Heffer; T. Hill; D. Isenhower; J. L. Klay; V. Kleinrath; N. Kornilov; A. B. Laptev; T. N. Massey; R. Meharchand; H. Qu; J. Ruz; S. Sangiorgio; B. Selhan; L. Snyder; S. Stave; G. Tatishvili; R. T. Thornton; F. Tovesson; D. Towell; R. S. Towell; S. Watson; B. Wendt; L. Wood

2013-03-09T23:59:59.000Z

195

Alabama Natural Gas Percentage Total Commercial Deliveries (Percent...  

Gasoline and Diesel Fuel Update (EIA)

Commercial Deliveries (Percent) Alabama Natural Gas Percentage Total Commercial Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

196

Utah Heat Content of Natural Gas Deliveries to Consumers (BTU...  

Annual Energy Outlook 2012 (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Utah Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1 Year-2...

197

Utah Natural Gas % of Total Residential Deliveries (Percent)  

Gasoline and Diesel Fuel Update (EIA)

% of Total Residential Deliveries (Percent) Utah Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

198

A prepaid architecture for solar electricity delivery in rural areas  

Science Conference Proceedings (OSTI)

This paper demonstrates a model for electricity delivery and revenue collection in a rural context with the potential to increase the reliability of service delivery and lower operating costs compared to traditional fixed monthly fee utilities. The microutility ...

Daniel Soto; Edwin Adkins; Matt Basinger; Rajesh Menon; Sebastian Rodriguez-Sanchez; Natasha Owczarek; Ivan Willig; Vijay Modi

2012-03-01T23:59:59.000Z

199

California Heat Content of Natural Gas Deliveries to Consumers...  

Gasoline and Diesel Fuel Update (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) California Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1...

200

California Natural Gas % of Total Residential Deliveries (Percent...  

Annual Energy Outlook 2012 (EIA)

% of Total Residential Deliveries (Percent) California Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Ohio Natural Gas % of Total Residential Deliveries (Percent)  

Gasoline and Diesel Fuel Update (EIA)

% of Total Residential Deliveries (Percent) Ohio Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

202

Ohio Heat Content of Natural Gas Deliveries to Consumers (BTU...  

Gasoline and Diesel Fuel Update (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Ohio Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1 Year-2...

203

Wisconsin Heat Content of Natural Gas Deliveries to Consumers...  

Gasoline and Diesel Fuel Update (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Wisconsin Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1...

204

Wisconsin Natural Gas % of Total Residential Deliveries (Percent...  

Annual Energy Outlook 2012 (EIA)

% of Total Residential Deliveries (Percent) Wisconsin Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

205

Michigan Heat Content of Natural Gas Deliveries to Consumers...  

Annual Energy Outlook 2012 (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Michigan Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1...

206

Michigan Natural Gas % of Total Residential Deliveries (Percent...  

Annual Energy Outlook 2012 (EIA)

% of Total Residential Deliveries (Percent) Michigan Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

207

Idaho Natural Gas % of Total Residential Deliveries (Percent...  

Gasoline and Diesel Fuel Update (EIA)

% of Total Residential Deliveries (Percent) Idaho Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

208

Idaho Heat Content of Natural Gas Deliveries to Consumers (BTU...  

Gasoline and Diesel Fuel Update (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Idaho Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1 Year-2...

209

California Natural Gas % of Total Electric Utility Deliveries...  

U.S. Energy Information Administration (EIA) Indexed Site

Electric Utility Deliveries (Percent) California Natural Gas % of Total Electric Utility Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

210

California Natural Gas Interstate Deliveries to All States (Million...  

U.S. Energy Information Administration (EIA) Indexed Site

Deliveries to All States (Million Cubic Feet) California Natural Gas Interstate Deliveries to All States (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5...

211

Vermont Natural Gas % of Total Residential Deliveries (Percent...  

Annual Energy Outlook 2012 (EIA)

% of Total Residential Deliveries (Percent) Vermont Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

212

Vermont Heat Content of Natural Gas Deliveries to Consumers ...  

Annual Energy Outlook 2012 (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Vermont Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1...

213

Colorado Natural Gas % of Total Residential Deliveries (Percent...  

Gasoline and Diesel Fuel Update (EIA)

% of Total Residential Deliveries (Percent) Colorado Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

214

Colorado Heat Content of Natural Gas Deliveries to Consumers...  

Annual Energy Outlook 2012 (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Colorado Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1...

215

Argonne Transportation - DOE H2A Delivery Analysis  

NLE Websites -- All DOE Office Websites (Extended Search)

DOE H2A Delivery Analysis Hydrogen delivery is an essential component of any future hydrogen energy infrastructure. Hydrogen must be transported from the point of production to the...

216

Deputy Secretary Poneman's Remarks as Prepared for Delivery at...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

as Prepared for Delivery at the American Chamber of Commerce in Korea Deputy Secretary Poneman's Remarks as Prepared for Delivery at the American Chamber of Commerce in Korea June...

217

Alabama Natural Gas Percentage Total Industrial Deliveries (Percent...  

Annual Energy Outlook 2012 (EIA)

Industrial Deliveries (Percent) Alabama Natural Gas Percentage Total Industrial Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

218

Illinois Natural Gas % of Total Residential Deliveries (Percent...  

Annual Energy Outlook 2012 (EIA)

% of Total Residential Deliveries (Percent) Illinois Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

219

Illinois Heat Content of Natural Gas Deliveries to Consumers...  

Annual Energy Outlook 2012 (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Illinois Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1...

220

New Mexico Natural Gas % of Total Residential Deliveries (Percent...  

Gasoline and Diesel Fuel Update (EIA)

% of Total Residential Deliveries (Percent) New Mexico Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

New Mexico Natural Gas % of Total Vehicle Fuel Deliveries (Percent...  

U.S. Energy Information Administration (EIA) Indexed Site

Vehicle Fuel Deliveries (Percent) New Mexico Natural Gas % of Total Vehicle Fuel Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

222

New Mexico Natural Gas Percentage Total Commercial Deliveries...  

U.S. Energy Information Administration (EIA) Indexed Site

Commercial Deliveries (Percent) New Mexico Natural Gas Percentage Total Commercial Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

223

New Mexico Heat Content of Natural Gas Deliveries to Consumers...  

Annual Energy Outlook 2012 (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) New Mexico Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1...

224

New Mexico Natural Gas % of Total Electric Utility Deliveries...  

U.S. Energy Information Administration (EIA) Indexed Site

Electric Utility Deliveries (Percent) New Mexico Natural Gas % of Total Electric Utility Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

225

New Mexico Natural Gas Percentage Total Industrial Deliveries...  

U.S. Energy Information Administration (EIA) Indexed Site

Industrial Deliveries (Percent) New Mexico Natural Gas Percentage Total Industrial Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

226

New Mexico Natural Gas Interstate Deliveries (Million Cubic Feet...  

U.S. Energy Information Administration (EIA) Indexed Site

Deliveries (Million Cubic Feet) New Mexico Natural Gas Interstate Deliveries (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

227

Texas Natural Gas Exports (No Intransit Deliveries) (Million...  

Annual Energy Outlook 2012 (EIA)

Exports (No Intransit Deliveries) (Million Cubic Feet) Texas Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5...

228

Texas Natural Gas % of Total Residential Deliveries (Percent...  

Gasoline and Diesel Fuel Update (EIA)

% of Total Residential Deliveries (Percent) Texas Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

229

Texas Heat Content of Natural Gas Deliveries to Consumers (BTU...  

Annual Energy Outlook 2012 (EIA)

Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Texas Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) Decade Year-0 Year-1 Year-2...

230

DOE Hydrogen Analysis Repository: H2A Delivery Components Model  

NLE Websites -- All DOE Office Websites (Extended Search)

Investigator: Matt Ringer Keywords: Hydrogen delivery; tube trailers; costs; pipelines Performer Principal Investigator: Matt Ringer Organization: National Renewable...

231

Office of Electricity Delivery and Energy Reliability | Department...  

NLE Websites -- All DOE Office Websites

of Electricity Delivery & Energy Reliability Services Electricity Advisory Committee Technology Development Electricity Policy Coordination and Implementation DOE Grid Tech Team...

232

2012 Annual Planning Summary for Electricity Delivery and Energy Reliability  

Energy.gov (U.S. Department of Energy (DOE))

The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2012 and 2013 within Electricity Delivery and Energy Reliability.

233

Alabama Aviation Gasoline All Sales/Deliveries by Prime ...  

U.S. Energy Information Administration (EIA)

View History: Monthly Annual : Download Data (XLS File) Alabama Aviation Gasoline All Sales/Deliveries by Prime Supplier ... Alabama Prices, ...

234

AFM Fluid Delivery/Liquid Extraction Surface Sampling ...  

Disclosure Number 201303009 . Technology Summary This invention is an Atomic Force Microscope (AFM) Fluid Delivery/Electrostatic ... The invention pro ...

235

Experimental verification of a real-time compensation functionality for dose changes due to target motion in scanned particle therapy  

SciTech Connect

Purpose: Implementation and experimental assessment of a real-time dose compensation system for beam tracking in scanned carbon beam therapy of intrafractionally moving targets. Methods: A real-time dose compensation functionality has been developed and implemented at the experimental branch of the beam tracking system at GSI Helmholtzzentrum fuer Schwerionenforschung (GSI). Treatment plans for different target geometries have been optimized. They have been delivered using scanned carbon ions with beam tracking (BT) and real-time dose compensation combined with beam tracking (RDBT), respectively. Target motion was introduced by a rotating table. Dose distributions were assessed by ionization chamber measurements and dose reconstructions. These distributions have been compared to stationary delivery for BT as well as RDBT. Additionally simulations have been performed to investigate the dependence of delivered dose distributions on varying motion starting phases for BT and RDBT, respectively. Results: Average measured dose differences between static delivery and motion influenced delivery could be reduced from 27-68 mGy when BT was used to 12-37 mGy when RDBT was used. Nominal dose was 1000 mGy. Simulated dose deliveries showed improvements in dose delivery and robustness against varying starting motion phases when RDBT was used. Conclusions: A real-time dose compensation functionality extending the existing beam tracking functionality has been implemented and verified by measurements. Measurements and simulated dose deliveries show that real-time dose compensation can substantially improve delivered dose distributions for large rotational target motion compared to beam tracking alone.

Luechtenborg, Robert; Saito, Nami; Durante, Marco; Bert, Christoph [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstrasse 1, 64291 Darmstadt, Germany Technische Universitaet Darmstadt, Institut fuer Festkoerperphysik, Hochschulstrasse 6-8, 64289 Darmstadt (Germany); GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstrasse 1, 64291 Darmstadt (Germany); GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstrasse 1, 64291 Darmstadt, Germany Technische Universitaet Darmstadt, Institut fuer Festkoerperphysik, Hochschulstrasse 6-8, 64289 Darmstadt (Germany); GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstrasse 1, 64291 Darmstadt (Germany)

2011-10-15T23:59:59.000Z

236

Reliability Centered Maintenance (RCM) Technical Reference for Power Delivery  

Science Conference Proceedings (OSTI)

The overall goal of Reliability Centered Maintenance (RCM) is to improve the economic posture of a utility by promoting cost-effective application of maintenance resources. EPRI's RCM Technical Reference for Power Delivery provides utilities with essential technical data and guidance for conducting RCM studies of power delivery equipment and systems. It serves as the "handbook" of RCM for the utility power delivery sector.

1997-11-04T23:59:59.000Z

237

Target Database | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Science & Engineering Applications Target Database The Target database and analytical pipeline provides bioinformatics support and selection of protein targets of biomedical...

238

Postoperative Irradiation of Gynecologic Malignancies: Improving Treatment Delivery Using Aperture-Based Intensity-Modulated Radiotherapy  

SciTech Connect

Purpose: To evaluate dosimetric and treatment delivery advantages of aperture-based intensity-modulated radiotherapy (AB-IMRT) for the treatment of patients receiving whole pelvic radiotherapy for gynecologic malignancies. Methods and Materials: Nineteen patients undergoing pelvic radiotherapy after resection of endometrial cancers were selected. A 45-Gy dose was prescribed to the target volume delineated on a planning CT scan. An in-house inverse planning system, Ballista, was used to develop a treatment plan using aperture-based multileaf collimator segments. This approach was compared with conventional four-field, enlarged four-field, and static beamlet-based IMRT (BB-IMRT) techniques in terms of target coverage, dose-volume histogram statistics for surrounding normal tissues, and numbers of segments and monitor units (MU). Results: Three quarters (76.4%) of the planning target volume received the prescription dose with conventional four-field plans. With adequate target coverage, the Ballista plans significantly reduced the volume of bowel and bladder irradiated at the prescribed dose (p < 0.001), whereas the two approaches provided equivalent results for the rectum (p 0.5). On the other hand, AB-IMRT and BB-IMRT plans showed only small differences in dose-volume histogram statistics of unknown clinical impact, whereas Ballista plan delivery required on average 73% and 59% fewer segments and MU, respectively. Conclusion: With respect to conventional techniques, AB-IMRT for the treatment of gynecologic malignancies provides dosimetric advantages similar to those with BB-IMRT but with clear treatment delivery improvements.

Nadeau, Sylvain [Departement de physique, de genie physique et d' optique, Universite Laval, Quebec, QC (Canada) and Departement de radio-oncologie et Centre de recherche de l' Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada)]. E-mail: sylvainn@rrsb.nb.ca; Bouchard, Myriam [Departement de radio-oncologie et Centre de recherche de l' Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Germain, Isabelle [Departement de radio-oncologie et Centre de recherche de l' Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Raymond, Paul-Emile [Departement de radio-oncologie et Centre de recherche de l' Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Beaulieu, Frederic [Departement de radio-oncologie et Centre de recherche de l' Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Beaulieu, Luc [Departement de physique, de genie physique et d' optique, Universite Laval, Quebec, QC (Canada); Departement de radio-oncologie et Centre de recherche de l' Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada); Roy, Rene [Departement de physique, de genie physique et d' optique, Universite Laval, Quebec, QC (Canada); Gingras, Luc [Departement de physique, de genie physique et d' optique, Universite Laval, Quebec, QC (Canada); Departement de radio-oncologie et Centre de recherche de l' Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Hotel-Dieu de Quebec, Quebec, QC (Canada)

2007-06-01T23:59:59.000Z

239

HYDROGEN ISOTOPE TARGETS  

DOE Patents (OSTI)

The design of targets for use in the investigation of nuclear reactions of hydrogen isotopes by bombardment with accelerated particles is described. The target con struction eomprises a backing disc of a metal selected from the group consisting of molybdenunn and tungsten, a eoating of condensed titaniunn on the dise, and a hydrogen isotope selected from the group consisting of deuterium and tritium absorbed in the coatiag. The proeess for preparing these hydrogen isotope targets is described.

Ashley, R.W.

1958-08-12T23:59:59.000Z

240

Target Cost Management Strategy  

E-Print Network (OSTI)

Target cost management (TCM) is an innovation of Japanese management accounting system and by common sense has been considered with great interest by practitioners. Nowadays, TCM related

Okano, Hiroshi

1996-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Assessment of ion-selective optical nanosensors for drug screening applications  

E-Print Network (OSTI)

Ion channels represent an important category of drug targets. They play a significant role in numerous physiological functions, from membrane excitation and signaling to fluid absorption and secretion. An ion-channel assay ...

Yun, Hannah

2007-01-01T23:59:59.000Z

242

DOE Hydrogen and Fuel Cells Program Record 12001: H2 Production and Delivery Cost Apportionment  

NLE Websites -- All DOE Office Websites (Extended Search)

01 Date: May 14, 2012 01 Date: May 14, 2012 Title: H 2 Production and Delivery Cost Apportionment Originator: Scott Weil, Sara Dillich, Fred Joseck, and Mark Ruth Approved by: Sunita Satyapal and Rick Farmer Date: December 14, 2012 Item: The hydrogen threshold cost is defined as the untaxed cost of hydrogen (H 2 ) (produced, delivered, and dispensed) at which hydrogen fuel cell electric vehicles (FCEVs) are projected to become competitive on a $/mile basis with competing vehicles [gasoline in hybrid-electric vehicles (HEVs)] in 2020. As established in Record 11007 [1], this cost ranges from $2.00-$4.00/gge a of H 2 (based on $2007). The threshold cost can be apportioned into its constituent H 2 production and delivery costs, which can then serve as the respective cost targets for multi-year planning of the Fuel Cell Technologies (FCT)

243

Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vectren Energy Delivery of Ohio (Gas) - Residential Energy Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency Rebates Vectren Energy Delivery of Ohio (Gas) - Residential Energy Efficiency Rebates < Back Eligibility Construction Installer/Contractor Residential Savings Category Heating & Cooling Commercial Heating & Cooling Heating Home Weatherization Commercial Weatherization Sealing Your Home Ventilation Appliances & Electronics Water Heating Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Furnace: $150 - $275 Boiler: $300 Storage Water Heater: $125 Tankless Water Heater: $150 Programmable Thermostat: $20 Attic Insulation: Up to $600 Wall Insulation: Up to $700 Air Sealing: Up to $250 Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery offers residential natural gas customers in Ohio

244

College of Electricity Delivery and Energy Reliability | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Electricity Delivery and Energy Reliability Electricity Delivery and Energy Reliability College of Electricity Delivery and Energy Reliability College of Electricity Delivery and Energy Reliability Vision OE recognizes that our Nation's sustained economic prosperity, quality of life, and global competitiveness depend on access to an abundance of secure, reliable, and affordable energy resources. Through a mix of technology and policy solutions, we will address the changing dynamics and uncertainties in which the electric system will operate. We will leverage effective partnerships, solid research, and best practices to address diverse interests in achieving economic, societal, and environmental objectives. Resources Explore the following topics at OE's College of Electricity Delivery and Energy Reliability:

245

Roadmap to Achieve Energy Delivery Systems Cybersecurity  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Roadmap to Achieve Energy Delivery Systems Cybersecurity Roadmap to Achieve Energy Delivery Systems Cybersecurity ii Acknowledgements The Energy Sector Control Systems Working Group (ESCSWG) developed this roadmap in support of the Electricity Sub-sector Coordinating Council, Oil and Natural Gas Sector Coordinating Council, and the Government Coordinating Council for Energy under the Critical Infrastructure Partnership Advisory Council (CIPAC) Framework; the roadmap has been approved for release by these councils. The ESCSWG members volunteered their time and expertise to this effort and would like to thank the other participants for their valuable perspectives and contributions to this important effort. Special thanks go to the U.S. Department of Energy, which provided the funds and support needed to convene participants

246

Office of Electricity Delivery and Energy Reliability  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Comments of Cisco Systems to Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Department of Energy in Response to Request for Information: Addressing Policy and Logistical Challenges to Smart Grid Implementation Issued September 13, 2010 FR Doc. 2010-23251 November 30, 2010 Cisco Systems provides these Comments in response to the Request for Information ("RFI") issued by the Office of Electricity Delivery and Energy Reliability of the Department of Energy ("DOE") on September 13, 2010. The RFI seeks information across a broad range of topics, but also requests that commenters be "concise," and provide "facts and concrete recommendations that can augment the general knowledge." 1 1. Interoperability Standards and the Smart Grid

247

Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

2 2 Electricity Delivery and Energy Reliability PROGRAM DESCRIPTION The Office of Electricity Delivery and Energy Reliability (OE) leads national efforts to modernize the electric grid, enhance security and reliability of energy infrastructure, and facilitate recovery from disruptions to the energy supply. As stated in the President's A Policy Framework for the 21 st Century Grid, a smarter, modernized electric grid is fundamental to transforming the Nation's energy system and securing US leadership in a clean energy future. OE supports activities that enable innovation across the energy sector, empower American consumers, and secure our energy future. OE consists of three programs: Research and Development; Permitting, Siting and Analysis; and Infrastructure Security and Energy Restoration.

248

Vulnerability Analysis of Energy Delivery Control Systems  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

0-18381 0-18381 Vulnerability Analysis of Energy Delivery Control Systems September 2011 Idaho National Laboratory Idaho Falls, Idaho 83415 http://www.inl.gov Prepared for the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability Under DOE Idaho Operations Office Contract DE-AC07-05ID14517 The INL is a U.S. Department of Energy National Laboratory operated by Battelle Energy Alliance DISCLAIMER This information was prepared as an account of work sponsored by an agency of the U.S. Government. Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness, of any information, apparatus, product, or

249

Final Report - Hydrogen Delivery Infrastructure Options Analysis  

NLE Websites -- All DOE Office Websites (Extended Search)

The Power of Experience The Power of Experience Final Report Hydrogen Delivery Infrastructure Options Analysis DOE Award Number: DE-FG36-05GO15032 Project director/principal investigator: Tan-Ping Chen Consortium/teaming Partners: Air Liquide, Chevron Technology Venture, Gas Technology Institute, NREL, Tiax, ANL Hydrogen Delivery Infrastructure Options Analysis ii TABLE OF CONTENTS SECTION 1 EXECUTIVE SUMMARY ........................................................................... 1-1 1.1 HOW THE RESEARCH ADDS TO THE UNDERSTANDING OF THE AREA INVESTIGATED. 1-1 1.2 TECHNICAL EFFECTIVENESS AND ECONOMIC FEASIBILITY OF THE METHODS OR TECHNIQUES INVESTIGATED OR DEMONSTRATED .................................................... 1-1 1.3 HOW THE PROJECT IS OF BENEFIT TO THE PUBLIC..................................................... 1-1

250

Improved Audit Implementation Through Programmed Report Delivery  

E-Print Network (OSTI)

Studies of energy audit recommendations have identified four primary barriers to implementation, perceived process interference, finances, organizational changes, and knowledge limitations leading to a bias against innovative technologies. To address these barriers, Georgia Tech engineers providing industrial audits have begun a program of delivering audit reports instead of mailing them. Although report delivery does not directly confront barriers relating to organization changes, it can be effective in dealing with the other three barriers. The delivery process is automated by using a personal computer and overhead projector to display relevant audit calculations, graphs, and tables as well as images of recommended equipment and maintenance concerns. The program elements can be modified depending on the plant and audit report contents.

Brown, M. L.; Gurta, M. E.; Meffert, W. A.

1995-04-01T23:59:59.000Z

251

Chemical biology drug discovery  

E-Print Network (OSTI)

Keywords Chemical biology drug discovery high-throughput screening protein ligands proteases novel chemical and biochemical methods for the identification and optimization of protein ligands us of pro- tein ligands. Results of this research are translated into protein-specific, chemical probes

Schüler, Axel

252

Parameter identification and model verification in systems of partial differential equations applied to transdermal drug delivery  

Science Conference Proceedings (OSTI)

The purpose of this paper is to present some numerical tools which facilitate the interpretation of simulation or data fitting results and which allow computation of optimal experimental designs. They help to validate mathematical models describing the ... Keywords: Confidence interval, Optimum experimental design, Parameter estimation, Partial differential equation, Transdermal application

Klaus Schittkowski

2008-12-01T23:59:59.000Z

253

Theoretical and experimental investigations of passive and ultrasound-enhanced transdermal drug delivery  

E-Print Network (OSTI)

In the initial investigation of this thesis, Fick's second law of diffusion was modified to describe both the transient, and the steady-state, transdermal transport of hydrophilic permeants through unbranched, aqueous pore ...

Kushner, Joseph, IV

2007-01-01T23:59:59.000Z

254

A Lorentz-force actuated controllable needle-free drug delivery system  

E-Print Network (OSTI)

The advantages of delivering injections via needle-free methods are numerous. However, conventional methods for needle-free injection lack sufficient control over depth of penetration and shape of injection. Thus, a ...

Hemond, Brian D. (Brian David Thomson)

2004-01-01T23:59:59.000Z

255

Nanostructured gene and drug delivery systems based on molecular self-assembly  

E-Print Network (OSTI)

Molecular self-assembly describes the assembly of molecular components into complex, supramolecular structures governed by weak, non-covalent interactions. In recent years, molecular self-assembly has been used extensively ...

Wood, Kris Cameron

2007-01-01T23:59:59.000Z

256

Synthesis of novel polymeric nanoparticles for hydrophobic and hydrophilic drug delivery  

E-Print Network (OSTI)

R. Langer, S. Jon, Angewandte Chemie- International EditionR. Langer, S. Jon, Angewandte Chemie- International EditionV. Vinogradov, Angewandte Chemie-International Edition 2009,

Sartor, Marta

2010-01-01T23:59:59.000Z

257

pH-sensitive core-shell nanoparticles for intracellular drug delivery  

E-Print Network (OSTI)

Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis ...

Hu, Yuhua, Ph. D. Massachusetts Institute of Technology

2008-01-01T23:59:59.000Z

258

Power Delivery Asset Management Information Sharing Method  

Science Conference Proceedings (OSTI)

EPRI's Power Delivery Asset Management (PDAM) Program has initiated an EPRI.com Collaboration website for its members. Using this tool, members can access important meeting documents as well as presentations from meetings and webcasts. Members can also post documents for comment and discussion between other members. This report describes the process for accessing and using the EPRI.com Collaboration site for PDAM. This site was established for the sole use of EPRI members participating in the PDAM program.

2008-12-22T23:59:59.000Z

259

Power Delivery Asset Management Decision Making Process  

Science Conference Proceedings (OSTI)

Asset management processes for electric utility fossil and nuclear generation were formalized and widely used during the 1990s. However, transmission and distribution asset management processes have been slower to evolve because of wide diversity in power delivery organizations, many dimensions of potential value, varying perceptions of value by various stakeholders, the need to accommodate uncertainty, and the need to align the actions of individuals with higher level corporate objectives. Therefore, t...

2008-12-18T23:59:59.000Z

260

Waste feed delivery planning at Hanford  

Science Conference Proceedings (OSTI)

The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

2013-01-10T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

DOE to Defer Strategic Petroleum Reserve RIK Deliveries | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

to Defer Strategic Petroleum Reserve RIK Deliveries to Defer Strategic Petroleum Reserve RIK Deliveries DOE to Defer Strategic Petroleum Reserve RIK Deliveries June 5, 2008 - 12:51pm Addthis 2.1 Million Barrels Delayed Until Spring 2009 WASHINGTON, DC - The U. S. Department of Energy today announced it will defer approximately 2.1 million barrels of royalty-in-kind (RIK) exchange crude oil that had been scheduled for delivery to the nation's Strategic Petroleum Reserve sites (SPR) this summer. The deferred deliveries are part of a royalty-in-kind crude oil exchange that began in January 2008 and were to total approximately 11 million barrels delivered to the SPR through July 2008. The approximately 2.1 million barrels will be deferred for delivery until March-May 2009, after the winter heating season. Deliveries of approximately 2.8 million

262

Development of alternating amphiphilic copolymers for targeted delivery applications in cancer  

E-Print Network (OSTI)

According to the American Cancer Society, approximately 1,479,000 new cases of cancer were expected to be diagnosed, while 562,340 Americans were expected to die from cancer in 2009 alone. Even though advances in early ...

Brower, Kevin P. (Kevin Peter)

2011-01-01T23:59:59.000Z

263

Target | Open Energy Information  

Open Energy Info (EERE)

Target Target Jump to: navigation, search Name Target Address 1000 Nicollet Mall Place Minneapolis, MN Zip 55440 Website http://www.target.com Coordinates 44.9739366°, -93.2750493° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.9739366,"lon":-93.2750493,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

264

Multiple shell fusion targets  

DOE Patents (OSTI)

Multiple shell fusion targets for use with electron beam and ion beam implosion systems are described. The multiple shell targets are of the low-power type and use a separate relatively low Z, low density ablator at large radius for the outer shell, which reduces the focusing and power requirements of the implosion system while maintaining reasonable aspect ratios. The targets use a high Z, high density pusher shell placed at a much smaller radius in order to obtain an aspect ratio small enough to protect against fluid instability. Velocity multiplication between these shells further lowers the power requirements. Careful tuning of the power profile and intershell density results in a low entropy implosion which allows breakeven at low powers. For example, with ion beams as a power source, breakeven at 10-20 Terrawatts with 10 MeV alpha particles for imploding a multiple shell target can be accomplished.

Lindl, J.D.; Bangerter, R.O.

1975-10-31T23:59:59.000Z

265

Report of the Production and Delivery Subgroup  

DOE Green Energy (OSTI)

The Production and Delivery Subgroup was tasked with evaluating the various options that could be used for hydrogen production and delivery in terms of availability/industry readiness, technical and economic barriers, and environmental considerations. Hydrogen can be produced using a variety of feedstocks and conversion technologies. The feedstock options include water, natural gas, coal, petroleum, methanol, ethanol, biomass, and organic waste streams. Ultimately, using these domestic resources we will be able to produce all the hydrogen we will need for the complete conversion of our transportation infrastructure. The various conversion technologies include electrolysis, reforming (principally of natural gas, but also ethanol and methanol), photobiological and photoelectrochemical, biofermentation, pyrolysis and gasification of biomass and coal, high temperature thermochemical, and catalytic membranes. All of these production technologies are being actively researched by DOE's Office of Hydrogen, Fuel Cells and Infrastructure Technologies (HFCIT); and other offices within DOE support work that complements the HFCIT Program activities. In addition, private industry is also dedicating significant resources to these efforts. In establishing the California Hydrogen Highway Network (CA H2 Net) we must utilize both distributed (that is, hydrogen that is produced at the point of use) as well as centralized production of hydrogen. Because of technical and economic barriers, most of the technologies for hydrogen production listed above will not become practical for either mode of hydrogen production in large quantities until at least the 2015-2030 timeframe. In the near term, that is, the transitional period between now and 2010 when we will establish a widely available hydrogen fueling infrastructure in California, the distributed production options of reforming and electrolysis will play the dominant role. In addition, production of hydrogen at centralized plants using natural gas reforming and delivery of pressurized or liquefied hydrogen by truck will be utilized. This is a logical extension of the current merchant hydrogen market.

Glass, R; Zalesky, R

2004-11-01T23:59:59.000Z

266

Report of the Production and Delivery Subgroup  

SciTech Connect

The Production and Delivery Subgroup was tasked with evaluating the various options that could be used for hydrogen production and delivery in terms of availability/industry readiness, technical and economic barriers, and environmental considerations. Hydrogen can be produced using a variety of feedstocks and conversion technologies. The feedstock options include water, natural gas, coal, petroleum, methanol, ethanol, biomass, and organic waste streams. Ultimately, using these domestic resources we will be able to produce all the hydrogen we will need for the complete conversion of our transportation infrastructure. The various conversion technologies include electrolysis, reforming (principally of natural gas, but also ethanol and methanol), photobiological and photoelectrochemical, biofermentation, pyrolysis and gasification of biomass and coal, high temperature thermochemical, and catalytic membranes. All of these production technologies are being actively researched by DOE's Office of Hydrogen, Fuel Cells and Infrastructure Technologies (HFCIT); and other offices within DOE support work that complements the HFCIT Program activities. In addition, private industry is also dedicating significant resources to these efforts. In establishing the California Hydrogen Highway Network (CA H2 Net) we must utilize both distributed (that is, hydrogen that is produced at the point of use) as well as centralized production of hydrogen. Because of technical and economic barriers, most of the technologies for hydrogen production listed above will not become practical for either mode of hydrogen production in large quantities until at least the 2015-2030 timeframe. In the near term, that is, the transitional period between now and 2010 when we will establish a widely available hydrogen fueling infrastructure in California, the distributed production options of reforming and electrolysis will play the dominant role. In addition, production of hydrogen at centralized plants using natural gas reforming and delivery of pressurized or liquefied hydrogen by truck will be utilized. This is a logical extension of the current merchant hydrogen market.

Glass, R; Zalesky, R

2004-11-01T23:59:59.000Z

267

Argus target chamber  

SciTech Connect

A target chamber for application in the laser fusion program must satisfy some very basic requirements. (1) Provide a vacuum on the order of 10$sup -6$ torr. (2) Support a microscopically small target in a fixed point in space and verify its location within 5 micrometers. (3) Contain an adjustable beam focusing system capable of delivering a number of laser beams onto the target simultaneously, both in time and space. (4) Provide access for diagnostics to evaluate the results of target irradiation. (5) Have flexibility to allow changes in targets, focusing optics and number of beams. The ARGUS laser which is now under construction at LLL will have a target chamber which meets these requirements in a simple economic manner. The chamber and auxiliary equipment are described, with reference to two double beam focusing systems; namely, lenses and ellipsoidal mirrors. Provision is made for future operation with four beams, using ellipsoidal mirrors for two-sided illumination and lens systems for tetragonal and tetrahedral irradiation. (auth)

Rienecker, F. Jr.; Glaros, S.S.; Kobierecki, M.

1975-11-12T23:59:59.000Z

268

Materials Solutions for Hydrogen Delivery in Pipelines  

NLE Websites -- All DOE Office Websites (Extended Search)

Solutions for Solutions for Hydrogen Delivery in Pipelines Dr. Subodh K. Das Secat, Inc. September 26, 2007 This presentation does not contain any proprietary, confidential, or otherwise restricted information Project Team SECAT (KY) Project Manager Oregon Steel Mills (OR) Steel Pipe Producer Columbia Gas of Kentucky (KY) NG transporter Schott North America (PA) Glass coatings supplier Chemical Composite Coatings (GA) Composites coatings Advanced Technology Corp. (TN) ABI technology provider ASME (NY) Codes and Standards DGS Metallurgical Solutions (OR) Steel consulting University of Illinois (IL) Basic embrittlement studies Oak Ridge National Laboratory (TN) Applied research Objective and Deliverables Objective: ∑ Develop materials technologies to minimize embrittlement of

269

Real time sensor for therapeutic radiation delivery  

DOE Patents (OSTI)

The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body. 14 figs.

Bliss, M.; Craig, R.A.; Reeder, P.L.

1998-01-06T23:59:59.000Z

270

Real time sensor for therapeutic radiation delivery  

DOE Patents (OSTI)

The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body.

Bliss, Mary (West Richland, WA); Craig, Richard A. (West Richland, WA); Reeder, Paul L. (Richland, WA)

1998-01-01T23:59:59.000Z

271

Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. The final agenda and welcome presentation are below. Presentations

272

H2A Delivery Scenario Model and Analyses  

NLE Websites -- All DOE Office Websites (Extended Search)

H2A Delivery Scenario Model H2A Delivery Scenario Model and Analyses Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office of Science U.S. Department of Energy Topics * Delivery Scenarios - Current status - Future scenarios * Delivery Scenarios model - Approach - Structure - Current status - Results * Pipeline modeling - Approach - Key assumptions - Results * Next Steps 3 Pioneering Science and Technology Office of Science U.S. Department of Energy Delivery Scenarios 4 Pioneering Science and Technology Office of Science U.S. Department of Energy Three-Quarters of the US Population Reside in Urbanized Areas East of the Mississippi there are many large, proximate urban areas. In the West

273

Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. The final agenda and welcome presentation are below. Presentations

274

Percentage of Total Natural Gas Industrial Deliveries included...  

U.S. Energy Information Administration (EIA) Indexed Site

Pipeline and Distribution Use Price City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial...

275

Examination of Terminal Land Requirements for Hydrogen Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

May 8, 2007 Jerry Gillette Examination of Terminal Land Requirements for Hydrogen Hydrogen Delivery Analysis Meeting Argonne National Laboratory A Variety of Terminal...

276

Winter LNG deliveries played a limited, yet important role - Today ...  

U.S. Energy Information Administration (EIA)

Total deliveries of liquefied natural gas ... terminals delivering natural gas into the Northeast market, at terminals that rely upon longer duration contracts, ...

277

Office of Electricity Delivery and Energy Reliability Cyber Security...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Cyber Security Project Selections Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections On September 23, 2010, speaking at the inaugural GridWise...

278

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Software Engineering Institute Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations from Carnegie Mellon University's Software Engineering

279

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Visualization and Modeling Visualization and Modeling Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Visualization and Modeling are below.

280

Office of Electricity Delivery And Energy Reliability To Hold...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy Reliability To Hold Technical...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

DOE Hydrogen Analysis Repository: H2 Delivery Infrastructure...  

NLE Websites -- All DOE Office Websites (Extended Search)

carriers. Keywords: Hydrogen delivery; Hydrogen infrastructure; tube trailers; pipelines Purpose This project will conduct an in-depth comparative analysis of the various...

282

Competition Advocates and Task-Order and Delivery Order Ombudsman...  

National Nuclear Security Administration (NNSA)

Delivery Order Ombudsman Home > About Us > Our Operations > Acquisition and Project Management > Office of Acquisition Management (OAM) > Competition Advocates and Task-Order and...

283

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers, industry partners, and academia from the Cybersecurity for...

284

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

for Energy Delivery Systems 2010 Peer Review Presentations - Visualization and Modeling National lab researchers, industry partners, and academia from the Cybersecurity for...

285

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Delivery Systems 2010 Peer Review Presentations - Best PracticesStandards Development National lab researchers, industry partners, and academia from the Cybersecurity for...

286

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Delivery Systems 2010 Peer Review Presentations - Best Practice DesignConfiguration National lab researchers, industry partners, and academia from the Cybersecurity for...

287

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry partners, and academia from the Cybersecurity for...

288

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia from the Cybersecurity for...

289

Specification of an Information Delivery Tool to Support Optimal...  

NLE Websites -- All DOE Office Websites (Extended Search)

Media Contacts Specification of an Information Delivery Tool to Support Optimal Holistic Environmental and Energy Management in Buildings Title Specification of an Information...

290

United Parcel Service Evaluates Hybrid Electric Delivery Vans...  

NLE Websites -- All DOE Office Websites (Extended Search)

fuel economy than comparable conventional vans. United Parcel Service Evaluates Hybrid Electric Delivery Vans Advanced Vehicle Testing This project is part of a series of...

291

Secretary of Energy Announces New Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

of Electricity Delivery & Energy Reliability June 9, 2005 - 9:26am Addthis WASHINGTON, DC -- Secretary of Energy Samuel Bodman today announced the completion of the merger of...

292

Joint Meeting on Hydrogen Delivery Modeling and Analysis, May...  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery Model: Discussion Items, Comments, and Follow-up Actions 1. Pipeline Pressures: Transmission, Trunk, and Distribution lines - Early on it may be difficult to do anything...

293

DOE Hydrogen Analysis Repository: H2A Delivery Scenario Analysis...  

NLE Websites -- All DOE Office Websites (Extended Search)

Scenario Analysis Model (HDSAM) Project Summary Full Title: H2A Delivery Scenario Analysis Model (HDSAM) Project ID: 218 Principal Investigator: Marianne Mintz Keywords: Models;...

294

H2A Delivery Components Model and Analysis  

NLE Websites -- All DOE Office Websites (Extended Search)

- Replacement capital includes for some components H2A Delivery Component Economic Analysis * The economic results presented assume specific scenario - Scenario refers to...

295

Office of Electricity Delivery and Energy Reliability | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Storm Karen Visit the Blog Current Topics Community Guidelines for Energy Emergencies Demand Response Cybersecurity for Energy Delivery Systems Energy Storage Modeling and...

296

PHEV Parcel Delivery Truck Model - Development and Preliminary Results (Presentation)  

DOE Green Energy (OSTI)

Describes results of a study to determine the impact of drive cycles on the energy- and cost-effectiveness of plug-in hybrid electric delivery vans.

Barnitt, R

2009-10-28T23:59:59.000Z

297

DOE Hydrogen and Fuel Cells Program: Hydrogen Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

refueling stations or stationary power facilities. Due to its relatively low volumetric energy density, transportation, storage and final delivery to the point of use can be one...

298

Energy Infrastructure Office of Electricity Delivery and Energy...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Comparing the Impacts of Northeast Hurricanes on Energy Infrastructure Office of Electricity Delivery and Energy Reliability U.S. Department of Energy April 2013 i For Further...

299

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

- Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program...

300

NREL: Hydrogen and Fuel Cells Research - Hydrogen Production and Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Hydrogen Production and Delivery Hydrogen Production and Delivery Most of the hydrogen in the United States is produced by steam reforming of natural gas. For the near term, this production method will continue to dominate. Researchers at NREL are developing advanced processes to produce hydrogen economically from sustainable resources. NREL's hydrogen production and delivery R&D efforts, which are led by Huyen Dinh, focus on the following topics: Biological Water Splitting Fermentation Conversion of Biomass and Wastes Photoelectrochemical Water Splitting Solar Thermal Water Splitting Renewable Electrolysis Hydrogen Dispenser Hose Reliability Hydrogen Production and Delivery Pathway Analysis. Biological Water Splitting Certain photosynthetic microbes use light energy to produce hydrogen from

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Hazard Evaluation for Waste Feed Delivery Operations and Activities  

Science Conference Proceedings (OSTI)

This document contains the results of the hazard analysis that has been performed to address Waste Feed Delivery operations and activities.

RYAN, G.W.

2000-03-10T23:59:59.000Z

302

South Dakota Heat Content of Natural Gas Deliveries to Consumers...  

Gasoline and Diesel Fuel Update (EIA)

View History: Annual Download Data (XLS File) South Dakota Heat Content of Natural Gas Deliveries to Consumers (BTU per Cubic Foot) South Dakota Heat Content of Natural Gas...

303

Percent of Industrial Natural Gas Deliveries in South Dakota...  

Annual Energy Outlook 2012 (EIA)

Monthly Annual Download Data (XLS File) Percent of Industrial Natural Gas Deliveries in South Dakota Represented by the Price (Percent) Percent of Industrial Natural Gas...

304

Percent of Commercial Natural Gas Deliveries in South Dakota...  

Annual Energy Outlook 2012 (EIA)

Monthly Annual Download Data (XLS File) Percent of Commercial Natural Gas Deliveries in South Dakota Represented by the Price (Percent) Percent of Commercial Natural Gas...

305

,"South Dakota Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

,"Workbook Contents" ,"South Dakota Natural Gas Deliveries to Electric Power Consumers (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","...

306

Microsoft Word - LCC-0135 Machine Protection Issues in the Beam Delivery System.doc  

NLE Websites -- All DOE Office Websites (Extended Search)

5 5 SLAC-TN-04-039 November 2003 Abstract This note documents a set of expressions used to explore the issue of whether or not it is reasonable to consider a conventional positron source for a Tesla formatted beam. The critical issue is that of energy deposition in the conversion target and the comparison of the induced stress with the ultimate tensile strength of the target material. Since the length of the incident beam pulse is large in comparison to the ratio of beam size to the speed of sound, the concurrent pressure pulse dissipates in a time short compared to the overall pulse duration and one is left with only the Machine Protection Issues in the Beam Delivery System L. Keller and T. Markiewicz Stanford Linear Accelerator Center

307

Foam encapsulated targets  

SciTech Connect

Foam encapsulated laser-fusion targets wherein a quantity of thermonuclear fuel is embedded in low density, microcellular foam which serves as an electron conduction channel for symmetrical implosion of the fuel by illumination of the target by one or more laser beams. The fuel, such as DT, is contained within a hollow shell constructed of glass, for example, with the foam having a cell size of preferably no greater than 2 .mu.m, a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3, and external diameter of less than 200 .mu.m.

Nuckolls, John H. (Livermore, CA); Thiessen, Albert R. (Livermore, CA); Dahlbacka, Glen H. (Livermore, CA)

1983-01-01T23:59:59.000Z

308

Realizing Technologies for Magnetized Target Fusion  

SciTech Connect

Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

Wurden, Glen A. [Los Alamos National Laboratory

2012-08-24T23:59:59.000Z

309

FABRICATION OF A NEW TYPE OF DOUBLE SHELL TARGET HAVING A PVA INNER LAYER  

SciTech Connect

OAK-B135 The General Atomics Target Fabrication team was tasked in FY03, under its ICF Target Support contract, to make a new type of double-shell target. its specifications called for the outer shell to have an inner lining of PVA (poly(vinyl alcohol)) that would keep the xenon gas fill from occupying the target wall. The inner shell consisted of a glass shell coated with 2000 {angstrom} of silver and filled with 9 atm of deuterium. Furthermore, the delivery deadline was less than seven weeks away. This paper describes the fielding of this double-shell target, made possible through the combined efforts of Lawrence Livermore National Laboratory and General Atomics target fabrication specialists.

STEINMAN,D.A; WALLACE,R; GRANT,S.E; HOPPE,M.L; SMITH,JR.J.N

2003-06-01T23:59:59.000Z

310

Targeted radionuclide therapy  

Science Conference Proceedings (OSTI)

Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F. [Radiology Division, City of Hope National Medical Center, Duarte, California 91010 (United States); Internal Medicine, University of California Davis Medical Center, 1508 Alhambra Boulevard, Suite 3100, Sacramento, California 95816 (United States); Department of Radiation Oncology, Wallace Tumor Institute WTI No. 117, University of Alabama at Birmingham, Birmingham, Alabama 35294 (United States)

2008-07-15T23:59:59.000Z

311

First SNS Target Replacement  

E-Print Network (OSTI)

· Replacement of the target module was accomplished using only remote handling tooling and procedures (hands operations. Remote Handling Control Room Manipulator Gallery #12;10 Managed by UT-Battelle for the U ­ Interim process fitting leak testing ­ Limitations on remote handling equipment reliability ­ Limitations

McDonald, Kirk

312

SNS Target Systems Operational  

E-Print Network (OSTI)

scheduling conflict with other remote handling work planned for the next shutdown. · The target and PBW integrated monolith and hot cell structures #12;32 Managed by UT-Battelle for the U.S. Department of Energy based on testing at Riken to 1.8 x 105 Gy · Improved neutronic performance and reduced remote handling

McDonald, Kirk

313

Office of Electricity Delivery and Energy Reliability  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Subtopic c. References: Subtopic c. References: 1. Thomas B. Johansson, Henry Kelly, Amulya K.N. Reddy, and Robert H. Williams, "Renewable Energy: Sources for Fuels and Electricity", Island Press, 1993 2. Patrick Takahashi and Andrew Trenka, "Ocean Thermal Energy Conversion", John Wiley & sons, 1996. *All references can be accessed at: http://archive.epri.com/oceanenergy/streamenergy.html#reports OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY 28. NATURAL DISASTER REDUCTION THROUGH TECHNOLOGY The U.S. electric power sector is a critical part of our society. Virtually all aspects of residential, industrial, and commercial activities depend on safe, reliable, and affordable electricity. Electricity is among the most infrastructure-intensive segments of the energy sector - the electricity grid includes a network of 5,000 power

314

LNG delivery system for gas powered vehicles  

Science Conference Proceedings (OSTI)

This patent describes a natural gas delivery system. It comprises a first vehicle mounted tank for storing liquid natural gas and natural gas vapor; a second vehicle mounted tank for storing liquid natural gas and natural gas vapor; a use line connected to the first and second tanks for receiving natural gas from the first and second tanks and delivering natural gas vapor to the use device on the vehicle and means for pressurizing the natural gas in the use line; means for selecting one of the first or second tanks to deliver natural gas to the use line; and means for overriding the selecting means to deliver natural gas vapor to the use line from either of the tanks in response to detecting a pressure rise therein which exceeds a preselected maximum.

Nesser, T.A.; Hedegard, K.W.

1992-07-07T23:59:59.000Z

315

Express location: supporting coordination of mobile delivery work  

Science Conference Proceedings (OSTI)

This paper introduces Express Location, a mobile web application, supporting drivers in delivery service in the daily coordination of work. Remote communication and cooperation takes place on a shared map view around the drivers' locations and next stop, ... Keywords: CSCW, delivery service, drawing, drivers, express location, field study, location-awareness, mobility, visual representations, workspace

Markus Westerlund; Maria Normark; Lars Erik Holmquist

2011-03-01T23:59:59.000Z

316

CIB White Paper on IDDS Integrated Design & Delivery Solutions  

E-Print Network (OSTI)

CIB White Paper on IDDS Integrated Design & Delivery Solutions Publication 328 ISBN 978-90-6363-060-7 #12;CIB White Paper on IDDS Page 1 of 15 CIB White Paper on IDDS Integrated Design & Delivery White Paper on IDDS Page 2 of 15 Table of Contents Introduction and Use of this White Paper

Amor, Robert

317

Adaptive Medical Information Delivery Combining User, Task and Situation Models  

E-Print Network (OSTI)

Adaptive Medical Information Delivery Combining User, Task and Situation Models Luis Francisco, USA +1409 845 4924 {lOfO954,shipman} @cs.tamu.edu ABSTRACT Medical information delivery for users for communication with Earth. The Mars Medical Assistant (MMA) uses a combination of user, situation, and task

Francisco-Revilla, Luis

318

Project delivery system selection of construction projects in China  

Science Conference Proceedings (OSTI)

Abstract: The suitability of the project delivery system (PDS) selected for a project greatly influences the efficiency to conduct a project. It is not an easy task to select an appropriate PDS as a large amount of ambiguous information exists. The paper ... Keywords: Artificial neural network, China, Construction project, Data envelopment analysis, Project delivery system

Yong Qiang Chen; Jun Ying Liu; Bingguang Li; Binshan Lin

2011-05-01T23:59:59.000Z

319

MADServer: a server architecture for mobile advanced delivery  

Science Conference Proceedings (OSTI)

Rapid increases in cellular data traffic demand creative alternative delivery vectors for data. Despite the conceptual attractiveness of mobile data offloading, no concrete web server architectures integrate intelligent offloading in a production-ready ... Keywords: cellular data offloading, delay tolerant cache, mobile advanced delivery

Agoston Petz; Anders Lindgren; Pan Hui; Christine Julien

2012-08-01T23:59:59.000Z

320

Mexico Border HIV Drug abuse  

E-Print Network (OSTI)

Ó The Author(s) 2011. This article is published with open access at Springerlink.com Abstract We examined correlates of ever injecting drugs in Mexico among residents of San Diego, California. From 2007 to 2010, injecting drug users (IDUs) in San Diego underwent an interviewer-administered survey. Logistic regression identified correlates of injection drug use in Mexico. Of 302 IDUs, 38 % were Hispanic, 72 % male and median age was 37; 27 % ever injected in Mexico; 43% reported distributive syringe sharing there. Factors independently associated with ever injecting drugs in Mexico included being younger at first injection, injecting heroin, distributive syringe sharing at least half of the time, and transporting drugs over the last 6 months. One-quarter of IDUs reported ever injecting drugs in Mexico, among whom syringe sharing was common, suggesting possible mixing between IDUs in the Mexico-US border region. Prospective studies should monitor trends in cross-border drug use in light of recent Mexican drug policy reforms partially decriminalizing drug possession.

Tyson Volkmann; Sanghyuk S. Shin; Richard S. Garfein; Irina Artamanova; Steffanie A. Strathdee; T. Volkmann; S. S. Shin; R. S. Garfein; R. A. Pollini; K. D. Wagner; I. Artamanova; S. A. Strathdee; T. L. Patterson

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Environmental Assessment : Muddy Ranch Point of Delivery.  

Science Conference Proceedings (OSTI)

Bonneville Power Administration's (BPA's) proposed action is to provide a new pint-of-delivery while Wasco Electric Cooperative (WEC, a preference customer of BPA) will build a new substation and transmission tapline for this new point-of-delivery as connected actions. If the action is not taken, system reliability in the area will be threatened in the near future. The load of the Clarno Basin, served by the Antelope substation, exclusive of the Muddy Ranch Development, is approximately 1000 kW. The connected load on the Muddy Ranch at present is approximately 2000 kW and recently has been growing at the rate of 400 kW per month. The Clarno load and the Muddy Ranch load, when totaled, is approximately 3000 kW at the present time. In an effort to maintain voltage on the system, WEC has installed three banks of regulators between Antelope and the Muddy Ranch, each of which boosts the voltage approximately 10%. Electrical service has been kept within usable standards through operation of these regulators and by voluntary curtailment of major uses on portions of the Muddy Ranch Development. However, the present condition does not meet normal standards expected under th American National Standards Institute for electrical service. With the load growth on the Muddy Ranch, and continued growth in electrical demand from the ranchers in the Clarno area, an extremely unstable operating condition is projected as early as the winter of 1982-1983. At that time, the existing facilities could be heavily overtaxed and damage could be caused to electrical pumps and other electrical applicances. 10 refs., 14 figs., 3 tabs.

United States. Bonneville Power Administration.

1982-09-01T23:59:59.000Z

322

Drug Detection Study  

Office of Scientific and Technical Information (OSTI)

ORISE-07-NSEM-0544 ORISE-07-NSEM-0544 U.S. Department of Energy Office of Health, Safety and Security Office of Security Policy Drug Retention Times Center for Human Reliability Studies Oak Ridge Institute for Science and Education Operated by Oak Ridge Associated Universities For the U.S. Department of Energy Oak Ridge Associated Universities (ORAU) is a university consortium leveraging the scientific strength of major research institutions to advance science and education by partnering with national laboratories, government agencies, and private industry. ORAU manages the Oak Ridge Institute for Science and Education for the U.S. Department of Energy. The Oak Ridge Institute for Science and Education (ORISE) is a U.S. Department of Energy institute focusing on

323

Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vectren Energy Delivery of Indiana (Gas) - Residential Energy Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency Rebates Vectren Energy Delivery of Indiana (Gas) - Residential Energy Efficiency Rebates < Back Eligibility Construction Residential Savings Category Heating & Cooling Commercial Heating & Cooling Heating Home Weatherization Commercial Weatherization Sealing Your Home Ventilation Program Info State Indiana Program Type Utility Rebate Program Rebate Amount Attic Insulation: 40% of cost, up to $450 Wall/Ceiling Insulation: 40% of cost, up to $450 Duct Sealing: Total cost, up to $400 Boilers: $300 Furnace: $150 - $275 Programmable Thermostat: $20 Provider Vectren Energy Delivery of Indiana Vectren Energy Delivery offers its residential natural gas customers in Indiana rebates for the installation of certain high efficiency natural gas

324

Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate Vectren Energy Delivery of Ohio (Gas) - Energy Star Home Rebate < Back Eligibility Construction Installer/Contractor Residential Savings Category Heating & Cooling Home Weatherization Construction Commercial Weatherization Commercial Heating & Cooling Design & Remodeling Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Full Adoption of Energy Star (Version 2.5) Standards: $750 Vectren Gold Star - HERS rating of 70 or less: $750 Furnace: $300 Boiler: $500 Tankless Water Heater: $150 Storage Water Heater: $50-$150 Programmable Thermostat: $20 Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery of Ohio offers a flat rebate to builders of residential single-family Energy Star certified homes that receive gas

325

Office of Electricity Delivery &amp; Energy Reliability Contributors |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Office of Electricity Delivery & Energy Reliability » Office of Office of Electricity Delivery & Energy Reliability » Office of Electricity Delivery & Energy Reliability Contributors Office of Electricity Delivery & Energy Reliability Contributors June 20, 2012 David Ortiz, OE-40 David Ortiz is Deputy Assistant Secretary for Energy Infrastructure Modeling and Analysis (EIMA) in the Department of Energy's Office of Electrici April 25, 2013 Eric Lightner June 22, 2011 Henry S. Kenchington, OE-50 Mr. Henry (Hank) Kenchington is Deputy Assistant Secretary (DAS) for the Advanced Grid Integration Division in the Department of Energy's Office of Electricity Delivery and Energy Reliability. He is responsible for the strategic management of the $3.4 billion Smart Grid Investment Grant program funded under the American Recovery and Reinvestment Act of 2009 to

326

National Electricity Delivery Division (NEDD) | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) National Electricity Delivery Division (NEDD) Timely, accurate and defensible policy and market analysis is a key ingredient to building and sustaining successful programs at DOE. The National Electricity Delivery Division coordinates OE's policy-related activities which include: Coordination of Federal Transmission Authorizations Section 1221(a) of EPACT added section 216(h) to the Federal Power Act, which requires that DOE act as the lead agency for purposes of coordinating all applicable Federal authorizations and related environmental reviews required to site an electric transmission facility. DOE and eight other Federal agencies have entered into a Memorandum of Understanding and DOE

327

Hydrogen Delivery: An Option to Ease the Transition  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery: Delivery: An Option to Ease the Transition Presentation at: The DOE Hydrogen and Fuel Cells Coordination Meeting Washington, D.C. June 3, 2003 John C. Winslow, Product Manager, Coal Fuels & Hydrogen National Energy Technology Laboratory Descriptor - include initials, /org#/date Hydrogen Delivery Today * Hydrogen infrastructure exists only for small merchant hydrogen markets in the chemical and refining industries * Current natural gas infrastructure consists of: - Pipelines - intermediate product storage - import terminals - rail, barge, and truck delivery U.S. Pipeline Mileage 0.7 2000 279 0 1000 2000 3000 Oil Nat Gas Hydrogen thousand miles Source: APCI, EIA, NEP Descriptor - include initials, /org#/date Comparison of Alternative Delivery Pathways Central H 2 production (coal)

328

Optical diagnostics integrated with laser spark delivery system  

DOE Patents (OSTI)

A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

Yalin, Azer (Fort Collins, CO); Willson, Bryan (Fort Collins, CO); Defoort, Morgan (Fort Collins, CO); Joshi, Sachin (Fort Collins, CO); Reynolds, Adam (Fort Collins, CO)

2008-09-02T23:59:59.000Z

329

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Electricity Electricity Delivery and Energy Reliability Categorical Exclusion Determinations: Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations issued by Electricity Delivery and Energy Reliability. DOCUMENTS AVAILABLE FOR DOWNLOAD September 18, 2012 CX-009236: Categorical Exclusion Determination Dynasty Power, Inc. Export Authorization CX(s) Applied: B4.2 Date: 09/18/2012 Location(s): Canada Offices(s): Electricity Delivery and Energy Reliability September 18, 2012 CX-009406: Categorical Exclusion Determination Rainbow Energy Marketing Corporation CX(s) Applied: B4.2 Date: 09/18/2012 Location(s): CX: none Offices(s): Electricity Delivery and Energy Reliability June 12, 2012 CX-008821: Categorical Exclusion Determination NRG Power Marketing, LLC Docket EA-384

330

Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity - 2011 As part of the Obama Administration's goals to enhance the security and reliability of the Nation's energy infrastructure, the U.S. Department of Energy released the 2011 Roadmap to Achieve Energy Delivery Systems Cybersecurity. Developed as an update to the 2006 Roadmap to Secure Control Systems in the Energy Sector, the report outlines a strategic framework over the next decade among industry, vendors, academia and government stakeholders to design, install, operate, and maintain a resilient energy delivery system capable of surviving a cyber incident while sustaining critical functions. Developed by the Energy Sector Control Systems Working Group, a partnership

331

DOE Hydrogen and Fuel Cells Program: DOE H2A Delivery Analysis  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery Carrier Components Overview Version 1.0 (PDF 415 KB) H2A Current (2010) Delivery Scenario Analysis Model Version 2.3 (Excel 8.6 MB) H2A Future (2020) Delivery Scenario...

332

DOE Hydrogen and Fuel Cells Program: 2008 Annual Progress Report - Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery Delivery Printable Version 2008 Annual Progress Report III. Delivery This section of the 2008 Progress Report for the DOE Hydrogen Program focuses on delivery. Each technical report is available as an individual Adobe Acrobat PDF. Download Adobe Reader. Hydrogen Delivery Sub-Program Overview, Rick Farmer, U.S. Department of Energy (PDF 218 KB) Hydrogen Delivery Infrastructure Options Analysis, TP Chen, Nexant, Inc. (PDF 242 KB) Hydrogen Delivery Infrastructure Analysis, Marrianne Mintz, Argonne National Laboratory (PDF 324 KB) Hydrogen Embrittlement of Pipelines: Fundamentals, Experiments, Modeling, Petros Sofronis, University of Illinois, Urbana-Champaign (PDF 686 KB) Materials Solutions for Hydrogen Delivery in Steel Pipeline, Subodh Das, Secat, Inc. (PDF 691 KB)

333

FY 2011 Budget Control Table for the Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1 Budget Control Table for the Office of Electricity Delivery and Energy Reliability FY 2011 Budget Control Table for the Office of Electricity Delivery and Energy Reliability...

334

FY 2012 Budget Control Table for the Office of Electricity Delivery...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FY 2012 Budget Control Table for the Office of Electricity Delivery and Energy Reliability FY 2012 Budget Control Table for the Office of Electricity Delivery and Energy...

335

Electro-osmotically driven liquid delivery method and apparatus  

DOE Patents (OSTI)

Method and apparatus are disclosed for controlling precisely the composition and delivery of liquid at sub-{micro}L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-{micro}L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column. 4 figs.

Rakestraw, D.J.; Anex, D.S.; Yan, C.; Dadoo, R.; Zare, R.N.

1999-08-24T23:59:59.000Z

336

Electro-osmotically driven liquid delivery method and apparatus  

DOE Patents (OSTI)

Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

Rakestraw, David J. (Fremont, CA); Anex, Deon S. (Livermore, CA); Yan, Chao (Pleasanton, CA); Dadoo, Rajeev (Stanford, CA); Zare, Richard N. (Stanford, CA)

1999-01-01T23:59:59.000Z

337

An Unusual Mechanism for the Antimicrobial Target Flavine-dependant  

NLE Websites -- All DOE Office Websites (Extended Search)

An Unusual Mechanism for the Antimicrobial An Unusual Mechanism for the Antimicrobial Target Flavine-dependant Thymidylate Synthase (FTDS) Classical thymidylate synthases, encoded by the thyA and TYMS genes, are present in most eukaryotes, including humans, and are frequently targeted by chemotherapeutic and antibiotic drugs. A recently discovered class of thymidylate synthases, the FDTSs encoded by the thyX gene has been found primarily in prokaryotes and viruses including several pathogens and biological warfare agents (see http://www.cdc.gov). Several organisms, including human pathogens, rely solely on thyX for thymidylate synthesis. FDTSs share no structure or sequence homology with classical thymidylate synthases (Fig 1), and thus present a promising new frontier for antibacterial/antiviral drug development.

338

Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vectren Energy Delivery of Indiana (Electric) - Commercial New Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction Rebates (Indiana) Vectren Energy Delivery of Indiana (Electric) - Commercial New Construction Rebates (Indiana) < Back Eligibility Commercial Fed. Government Industrial Local Government Nonprofit State Government Savings Category Home Weatherization Commercial Weatherization Heating & Cooling Commercial Heating & Cooling Cooling Other Heat Pumps Appliances & Electronics Commercial Lighting Lighting Windows, Doors, & Skylights Maximum Rebate Custom/HVAC Systems: $100,000 or 50% of the total project cost Incentive cannot buy down project below 1.5 years payback. Program Info State Indiana Program Type Utility Rebate Program Rebate Amount HVAC Systems (New Construction): $0.12/kWh reduced

339

A Collaborative Infrastructure for Scalable and Robust News Delivery  

E-Print Network (OSTI)

In this paper we describe the model used for the News Wire collaborative content delivery system. The system builds on the robustness and scalability of Astrolabe to weave a peer-to-peer infrastructure for real-time delivery of news items. The goal of the system is to deliver news updates to hundreds of thousands of subscribers within tens of seconds of the moment of publishing. The system significantly reduces the compute and network load at the publishers and guarantees delivery even in the face of publisher overload or denial of service attacks.

Werner Vogels Cornell; Werner Vogels; Ken Birman

2002-01-01T23:59:59.000Z

340

Learning to target: what works for behavioral targeting  

Science Conference Proceedings (OSTI)

Understanding what interests and delights users is critical to effective behavioral targeting, especially in information-poor contexts. As users interact with content and advertising, their passive behavior can reveal their interests towards advertising. ... Keywords: advertising, behavioral targeting, user modeling

Sandeep Pandey; Mohamed Aly; Abraham Bagherjeiran; Andrew Hatch; Peter Ciccolo; Adwait Ratnaparkhi; Martin Zinkevich

2011-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Fluid Delivery System For Capillary Electrophoretic Applications.  

DOE Patents (OSTI)

An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.

Li, Qingbo (State College, PA); Liu, Changsheng (State College, PA); Kane, Thomas E. (State College, PA); Kernan, John R. (Loganton, PA); Sonnenschein, Bernard (Brooklyn, NY); Sharer, Michael V. (Tyrone, PA)

2002-04-23T23:59:59.000Z

342

Rethinking hydrogen fueling insights from delivery modeling.  

SciTech Connect

Over the past century gasoline fueling has evolved from being performed by a variety of informal, diverse methods to being performed through the use of a standardized, highly automated system that exploits the fuel's benefits and mitigates its hazards. Any effort to transition to another fuel with different properties--with both advantages and disadvantages--must make similar adjustments. This paper discusses the existing gasoline refueling infrastructure and its evolution. It then describes the hydrogen delivery scenario analysis model, an Excel-based tool that calculates the levelized cost of delivering hydrogen from a central production facility to a vehicle by the use of currently available technologies and a typical profile of vehicle use and fueling demand. The results are shown for a status quo, or gasoline-centric case, in which demand reflects the current gasoline-based system and supply responds accordingly, and a hydrogen-centric case, in which some of those patterns are altered. The paper highlights fueling requirements that are particularly problematic for hydrogen and concludes with a discussion of alternative fueling paradigms.

Mintz, M.; Elgowainy, A.; Gardiner, M.; Energy Systems; U. S. DOE

2009-01-01T23:59:59.000Z

343

Using a shallow linguistic kernel for drug-drug interaction extraction  

Science Conference Proceedings (OSTI)

A drug-drug interaction (DDI) occurs when one drug influences the level or activity of another drug. Information Extraction (IE) techniques can provide health care professionals with an interesting way to reduce time spent reviewing the literature for ... Keywords: Biomedical information extraction, Drug-drug interactions, Machine learning, MetaMap, Patient safety, Shallow linguistic kernel, Unified medical language system

Isabel Segura-Bedmar; Paloma MartíNez; Cesar De Pablo-SáNchez

2011-10-01T23:59:59.000Z

344

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vulnerability and Intrusion Detection Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Vulnerability and Instrusion Detection are below.

345

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vulnerability and Intrusion Detection Vulnerability and Intrusion Detection Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Vulnerability and Instrusion Detection are below.

346

Oncor Electric Delivery Company LLC | Open Energy Information  

Open Energy Info (EERE)

Oncor Electric Delivery Company LLC Oncor Electric Delivery Company LLC (Redirected from Oncor Electric Delivery Company, LLC) Jump to: navigation, search Name Oncor Electric Delivery Company LLC Place Texas Service Territory Texas Website www.oncor.com/EN/Pages/de Green Button Landing Page www.smartmetertexas.com/C Green Button Reference Page www.emeter.com/smart-grid Green Button Implemented Yes Utility Id 44372 Utility Location Yes Ownership I NERC Location TRE NERC ERCOT Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Buying Distribution Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it.

347

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Best Practices/Standards Development Best Practices/Standards Development Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practices/Standards Development National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Best Practices/Standards Development are below.

348

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Trustworthy Cyber Infrastructure for the Power Grid (TCIPG) National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs.

349

The Office of Electricity Delivery and Energy Reliability is Closely  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

The Office of Electricity Delivery and Energy Reliability is The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) The Office of Electricity Delivery and Energy Reliability is Closely Monitoring Hurricane Irene (2011) August 25, 2011 - 11:13am Addthis The Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is closely monitoring Hurricane Irene as it travels up the U.S. coast and is publishing Situation Reports. Addthis Related Articles Sandy made landfall as a post-tropical cyclone on the southern coast of New Jersey near Atlantic City at 8 p.m. on October 29, with top sustained winds of 80 mph. | Photo courtesy of NOAA. Responding To Hurricane Sandy: DOE Situation Reports On November 7, a Nor'easter began to impact the Mid-Atlantic and Northeast with strong winds, rain or snow, and coastal flooding. | Photo courtesy of NOAA.

350

Secretary Chu's Remarks as Prepared for Delivery at the Washington  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

as Prepared for Delivery at the Washington as Prepared for Delivery at the Washington University Commencement Secretary Chu's Remarks as Prepared for Delivery at the Washington University Commencement May 21, 2010 - 12:00am Addthis Remarks of Secretary Steven Chu- As Prepared for Delivery Washington University Friday, May 21, 2010 Chancellor Mark Wrighton, the Board of Trustees, faculty, family, and friends here today, thank you for letting me share this wonderful day with you. It is a special privilege to return to the campus where my father began his career as a professor of chemical engineering. To the new graduates: Congratulations on your achievements. This year is the 40th anniversary of my own commencement. I know from personal experience that you will probably not remember what I will have said five years from today. I could stand here and read the phone book -

351

Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results  

NLE Websites -- All DOE Office Websites (Extended Search)

to Hydrogen to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad Elgowainy Argonne National Laboratory Comparison of Delivery Pathways- V1.0 vs. V2.0 2 1 3 i delivery by a Loading, the plant Version 1.0 character zed components for 3 pathways with single mode. conditioning and storage are at or adjacent to Liquid Hydrogen (LH) Truck H2 Production 100 or 1500 kg/d Compressed H2 (CH) Truck H2 Production 3 or 7 kpsi 100 or 1500 kg/d H2 Production Gaseous H2 Pipeline 100 or 1500 kg/d HDSAM V1.0 Estimates Delivery Cost for 3 Pathways 4 H2 H2 1 2 3 H2 Distribution and Ci I. Liquid H2 Distribution: HDSAM V2.0 Simulates Nine Pathways Production Production LH Terminal LH Terminal Production LH Terminal Transmission Transmission Distribution

352

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Secure Communications Secure Communications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Secure Communications National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Secure Communications are below. CEDS 2010 Peer Review - Cryptographic Trust Management - Mark Hadley,

353

EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts EM's Indefinite Delivery/Indefinite Quantity Cleanup Contracts The Office of Environmental Management (EM) has 23 Indefinite Delivery/Indefinite Quantity (IDIQ) contracts to provide cleanup services at EM sites across the United States. The scope of work of the IDIQ contracts includes: environmental remediation deactivation, decommissioning, demolition and removal of contaminated facilities waste management regulatory compliance These nationwide, multiple-award IDIQ contracts allow EM sites to place timely, competitive and cost-effective task orders for environmental services with either large or small businesses, as determined by the complexity of the requirements. Twelve of the IDIQ contracts were awarded

354

Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology  

NLE Websites -- All DOE Office Websites (Extended Search)

delivery of compressed hydrogen delivery of compressed hydrogen with advanced vessel technology Gene Berry Andrew Weisberg Salvador M. Aceves Lawrence Livermore National Laboratory (925) 422-0864 saceves@LLNL.GOV DOE and FreedomCar & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop Washington, DC January 25, 2006 LLNL is developing innovative concepts for efficient containment of hydrogen in light duty vehicles concepts may offer advantages for hydrogen delivery Conformable containers efficiently use available space in the vehicle. We are pursuing multiple approaches to conformability High Strength insulated pressure vessels extend LH 2 dormancy 10x, eliminate boiloff, and enable efficiencies of flexible refueling (compressed/cryogenic H 2 /(L)H 2 ) The PVT properties of H

355

FedEx Express Gasoline Hybrid Electric Delivery Truck Evaluation...  

NLE Websites -- All DOE Office Websites (Extended Search)

FedEx Express Gasoline Hybrid Electric Delivery Truck Evaluation: 12-Month Report R. Barnitt Technical Report NRELTP-5400-48896 January 2011 NREL is a national laboratory of the...

356

California Total Gasoline All Sales/Deliveries by Prime Supplier ...  

U.S. Energy Information Administration (EIA)

California Total Gasoline All Sales/Deliveries by Prime Supplier (Thousand Gallons per Day) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9;

357

California Natural Gas Deliveries to Electric Power Consumers ...  

U.S. Energy Information Administration (EIA)

California Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9; 1990's:

358

Ohio Natural Gas Deliveries to Electric Power Consumers (Million ...  

U.S. Energy Information Administration (EIA)

Ohio Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9; 1990's: 3,491:

359

Cost-reduced Cable Delivery for the 21st Century  

Science Conference Proceedings (OSTI)

This paper addresses the issue of cost-effective optical fibre cable delivery within current projections of fibre build. The implications are generally valid for fibre to the home (FTTH), but additional considerations will apply. The challenge lies in ...

A. J. Mayhew; D. J. Stockton

1998-10-01T23:59:59.000Z

360

Colorado Natural Gas Deliveries to Electric Power Consumers ...  

U.S. Energy Information Administration (EIA)

Colorado Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9; 1990's ...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Texas Total Gasoline All Sales/Deliveries by Prime Supplier ...  

U.S. Energy Information Administration (EIA)

Texas Total Gasoline All Sales/Deliveries by Prime Supplier (Thousand Gallons per Day) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec; 1983: 26,179.1: 26,695.0 ...

362

Agility at scale: economic governance, measured improvement, and disciplined delivery  

Science Conference Proceedings (OSTI)

Agility without discipline cannot scale, and discipline without agility cannot compete. Agile methods are now mainstream. Software enterprises are adopting these practices in broad, comprehensive delivery contexts. There have been many successes, and ...

Alan W. Brown, Scott Ambler, Walker Royce

2013-05-01T23:59:59.000Z

363

Michigan Natural Gas Deliveries to Electric Power Consumers ...  

U.S. Energy Information Administration (EIA)

Michigan Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9; 1990's:

364

Michigan Kerosene Adj Sales/Deliveries to Residential Consumers ...  

U.S. Energy Information Administration (EIA)

Michigan Kerosene Adj Sales/Deliveries to Residential Consumers (Thousand Gallons) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9; 1980's:

365

A vector-free microfluidic platform for intracellular delivery  

E-Print Network (OSTI)

Intracellular delivery of macromolecules is a challenge in research and therapeutic applications. Existing vector-based and physical methods have limitations, including their reliance on exogenous materials or electrical ...

Sharei, Armon Reza

366

Delivery optimization for a make to order custom wire mill  

E-Print Network (OSTI)

In the face of growing competition in the Tantalum business, H.C.Starck's management is minimizing the delivery time for custom-made capacitor-grade tantalum wire products. H.C. Starck, Inc., Newton, Massachusetts faces ...

Slivinskiy, Andrey L

2005-01-01T23:59:59.000Z

367

Colorado Total Distillate Adj Sales/Deliveries to Military ...  

U.S. Energy Information Administration (EIA)

Colorado Total Distillate Adj Sales/Deliveries to Military Consumers (Thousand Gallons) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 ...

368

Colorado Total Gasoline All Sales/Deliveries by Prime Supplier ...  

U.S. Energy Information Administration (EIA)

Colorado Total Gasoline All Sales/Deliveries by Prime Supplier (Thousand Gallons per Day) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9;

369

Office of Electricity Delivery And Energy Reliability To Hold Technical  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Office of Electricity Delivery And Energy Reliability To Hold Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission February 5, 2009 - 10:57am Addthis On March 4, 2009, the Department of Energy's Office of Electricity Delivery and Energy Reliability (OE) will conduct a technical conference in the Washington, DC area to discuss the design of future electric transmission. The technical conference will discuss the likely demand for future electric transmission and whether the development of conceptual alternative extra high voltage (EHV) systems would assist generation developers, State energy policy officials, utility planners, and other

370

Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations -  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Practice Design/Configuration Practice Design/Configuration Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best Practice Design/Configuration National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy Sector Control Systems Working Group provided technical feedback and recommendations to each project to ensure DOE continues to support robust projects that meet industry needs. Presentations on Best Practice Design/Configuration are below.

371

New York Natural Gas Deliveries to Electric Power Consumers ...  

U.S. Energy Information Administration (EIA)

New York Natural Gas Deliveries to Electric Power Consumers (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 ...

372

Illinois Kerosene Sales/Deliveries to Residential Consumers ...  

U.S. Energy Information Administration (EIA)

Illinois Kerosene Sales/Deliveries to Residential Consumers (Thousand Gallons) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9; 1980's ...

373

,"New Mexico Natural Gas Deliveries to Electric Power Consumers...  

U.S. Energy Information Administration (EIA) Indexed Site

,,"(202) 586-8800",,,"10312013 3:28:06 PM" "Back to Contents","Data 1: New Mexico Natural Gas Deliveries to Electric Power Consumers (MMcf)" "Sourcekey","N3045NM2"...

374

Telerobotic system concept for real-time soft-tissue imaging during radiotherapy beam delivery  

Science Conference Proceedings (OSTI)

Purpose: The curative potential of external beam radiation therapy is critically dependent on having the ability to accurately aim radiation beams at intended targets while avoiding surrounding healthy tissues. However, existing technologies are incapable of real-time, volumetric, soft-tissue imaging during radiation beam delivery, when accurate target tracking is most critical. The authors address this challenge in the development and evaluation of a novel, minimally interfering, telerobotic ultrasound (U.S.) imaging system that can be integrated with existing medical linear accelerators (LINACs) for therapy guidance. Methods: A customized human-safe robotic manipulator was designed and built to control the pressure and pitch of an abdominal U.S. transducer while avoiding LINAC gantry collisions. A haptic device was integrated to remotely control the robotic manipulator motion and U.S. image acquisition outside the LINAC room. The ability of the system to continuously maintain high quality prostate images was evaluated in volunteers over extended time periods. Treatment feasibility was assessed by comparing a clinically deployed prostate treatment plan to an alternative plan in which beam directions were restricted to sectors that did not interfere with the transabdominal U.S. transducer. To demonstrate imaging capability concurrent with delivery, robot performance and U.S. target tracking in a phantom were tested with a 15 MV radiation beam active. Results: Remote image acquisition and maintenance of image quality with the haptic interface was successfully demonstrated over 10 min periods in representative treatment setups of volunteers. Furthermore, the robot's ability to maintain a constant probe force and desired pitch angle was unaffected by the LINAC beam. For a representative prostate patient, the dose-volume histogram (DVH) for a plan with restricted sectors remained virtually identical to the DVH of a clinically deployed plan. With reduced margins, as would be enabled by real-time imaging, gross tumor volume coverage was identical while notable reductions of bladder and rectal volumes exposed to large doses were possible. The quality of U.S. images obtained during beam operation was not appreciably degraded by radiofrequency interference and 2D tracking of a phantom object in U.S. images obtained with the beam on/off yielded no significant differences. Conclusions: Remotely controlled robotic U.S. imaging is feasible in the radiotherapy environment and for the first time may offer real-time volumetric soft-tissue guidance concurrent with radiotherapy delivery.

Schlosser, Jeffrey; Salisbury, Kenneth; Hristov, Dimitre [Department of Mechanical Engineering, Stanford University, Stanford, California 94305 (United States); Department of Computer Science and Department of Surgery, Stanford University, Stanford, California 94305 (United States); Department of Radiation Oncology, Stanford University, Stanford, California 94305 (United States)

2010-12-15T23:59:59.000Z

375

Delivery system for molten salt oxidation of solid waste  

DOE Patents (OSTI)

The present invention is a delivery system for safety injecting solid waste particles, including mixed wastes, into a molten salt bath for destruction by the process of molten salt oxidation. The delivery system includes a feeder system and an injector that allow the solid waste stream to be accurately metered, evenly dispersed in the oxidant gas, and maintained at a temperature below incineration temperature while entering the molten salt reactor.

Brummond, William A. (Livermore, CA); Squire, Dwight V. (Livermore, CA); Robinson, Jeffrey A. (Manteca, CA); House, Palmer A. (Walnut Creek, CA)

2002-01-01T23:59:59.000Z

376

Reliability Centered Maintenance (RCM) Technical Reference for Power Delivery  

Science Conference Proceedings (OSTI)

This technical reference expands on the original reliability centered maintenance (RCM) research performed by EPRI in the late 1990s. It incorporates nearly ten years of utility RCM experience in power delivery and emphasizes the requirements of managing and measuring maintenance programs. RCM's overall goal is to improve the economic posture of a utility by promoting cost-effective application of maintenance resources. This "Technical Reference for Power Delivery" serves as the "handbook" of RCM for the...

2003-12-10T23:59:59.000Z

377

Beam heating of target foils  

SciTech Connect

A target rotator, built to reduce the effects of beam spot heating, is fully adjustable, holds three targets, is chamber independent, and takes up limited space. The expected temperature rise in the target is calculated from the Stefan--Boltzmann law. (PMA)

Corwin, W.C.

1975-01-01T23:59:59.000Z

378

Percentage of Total Natural Gas Commercial Deliveries included in Prices  

Gasoline and Diesel Fuel Update (EIA)

City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area May-13 Jun-13 Jul-13 Aug-13 Sep-13 Oct-13 View History U.S. 63.3 59.3 57.9 57.0 57.4 61.3 1983-2013 Alabama 71.7 71.0 68.5 68.2 68.4 66.7 1989-2013 Alaska 94.1 91.6 91.1 91.0 92.3 92.6 1989-2013 Arizona 84.0 83.0 81.6 80.3 82.8 82.7 1989-2013 Arkansas 37.8 28.3 28.1 28.6 26.7 28.0 1989-2013

379

Percentage of Total Natural Gas Industrial Deliveries included in Prices  

Gasoline and Diesel Fuel Update (EIA)

City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area May-13 Jun-13 Jul-13 Aug-13 Sep-13 Oct-13 View History U.S. 16.5 16.3 16.0 16.2 16.6 16.9 2001-2013 Alabama 22.1 21.7 21.6 22.8 22.0 22.7 2001-2013 Alaska 100.0 100.0 100.0 100.0 100.0 100.0 2001-2013 Arizona 13.4 15.7 15.3 13.8 13.7 13.9 2001-2013 Arkansas 1.7 1.4 1.2 1.4 1.3 1.5 2001-2013

380

Percent of Industrial Natural Gas Deliveries in U.S. Total ...  

U.S. Energy Information Administration (EIA)

Percentage of Total Natural Gas Industrial Deliveries included in Prices ; U.S. Natural Gas Prices ...

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Percent of Commercial Natural Gas Deliveries in U.S. Total ...  

U.S. Energy Information Administration (EIA)

Percentage of Total Natural Gas Commercial Deliveries included in Prices ; U.S. Natural Gas Prices ...

382

Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery (Presentation)  

DOE Green Energy (OSTI)

This presentation summarizes "A Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery".

Jalalzadeh-Azar, A.

2010-10-18T23:59:59.000Z

383

North Carolina No 2 Fuel Oil / Heating Oil Sales/Deliveries to ...  

U.S. Energy Information Administration (EIA)

North Carolina No 2 Fuel Oil / Heating Oil Sales/Deliveries to Industrial Consumers (Thousand Gallons)

384

North Carolina No 2 Fuel Oil / Heating Oil Sales/Deliveries to ...  

U.S. Energy Information Administration (EIA)

North Carolina No 2 Fuel Oil / Heating Oil Sales/Deliveries to Commercial Consumers (Thousand Gallons)

385

PDFs for nuclear targets  

E-Print Network (OSTI)

Understanding nuclear effects in parton distribution functions (PDF) is an essential component needed to determine the strange and anti-strange quark contributions in the proton. In addition Nuclear Parton Distribution Functions (NPDF) are critically important for any collider experiment with nuclei (e.g. RHIC, ALICE). Here two next-to-leading order chi^2-analyses of NPDF are presented. The first uses neutral current charged-lepton Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DIS data. We compare the nuclear corrections factors (F_2^Fe/F_2^D) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.

Karol Kovarik

2010-06-25T23:59:59.000Z

386

ORION laser target diagnostics  

SciTech Connect

The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K. [Plasma Physics Department, Atomic Weapons Establishment, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); and others

2012-10-15T23:59:59.000Z

387

Cost Comparison of Collaborative and IPD-like Project Delivery Methods Versus Competitive Non-collaborative Project Delivery Methods  

E-Print Network (OSTI)

Collaborative project delivery methods are believed to contribute to faster completions times, lower overall project costs and higher quality. Contracts are expected to influence the degree of collaboration on a given project since they allow or restrict certain lines of communication in the decision making process. Various delivery systems rank differently on the spectrum of collaboration. Because collaborative project delivery methods require owners and AEC stakeholders to meet frequently early in the delivery process, they are thought to add additional upfront costs to the project. The purpose of this study is to test if collaborative project delivery methods impart enough value so that the upfront cost incurred at the beginning of project is eventually surpassed by realized savings. Ideally, the extreme forms of project delivery methods, that is, Integrated Project Delivery (IPD) and Design-Bid-Build (DBB), should be compared to test the effects of collaboration on benefits to the owner. Due to difficulty in obtaining data on IPD and similarly scaled DBB projects, for this study, their close cousins, CM-at-Risk (CMR) and Competitive Sealed Proposal (CSP) were compared. The study engaged statistical comparison of cost of change orders and overall project cost performance of 17 CMR and 13 CSP projects of similar scales by same owner. Project cost performance observed under CMR projects was found significantly more than those under CSP. This study is expected to help boost confidence in the benefits of collaborative project delivery methods. It is likely that the results will encourage acceptance of IPD for public projects. Owners who were previously discouraged by the increased upfront cost of collaborative projects may also find interest in the results of this study.

Kulkarni, Aditi

2012-05-01T23:59:59.000Z

388

Targeting Political Advertising on Television ?  

E-Print Network (OSTI)

We study the targeting of political advertising by congressional candidates on television. Targeting strategies for television differ from targeting strategies for direct mail advertising or get out the vote efforts because candidates cannot target voters individually. Instead, candidates must target television programs with viewers most similar to the desired target voters. Thus, for targeted advertising to have value, the audiences for television programs must differ in meaningful ways and advertising must be effective. In this project, we develop and estimate a model of targeted advertising for U.S. congressional races. We study whether television shows segment potential voters sufficiently to allow for effective targeting and we consider the effect of television advertising- whether it persuades individuals to vote for a particular candidate or mobilizes them to vote in general. Our results suggest the function of television advertising is primarily to persuade. Moreover, we find that there is sufficient variation in the distribution of viewer characteristics across television programs to allow for effective targeting. The most effective targeting strategies therefore involve both parties adopting similar strategies of advertising primarily on programs with audiences containing many swing voters that are likely to vote. While

Mitchell Lovett; Michael Peress

2010-01-01T23:59:59.000Z

389

In silico approach to discover multi-target-directed ligands for the treatment of Alzheimer's disease  

Science Conference Proceedings (OSTI)

Multi-target directed (MTD) drugs have been found to be very effective in controlling neurodegenerative diseases. We have developed an in silico strategy to screen molecules for both AChE and BACE-1 enzyme dual inhibition. Pharmacophore model ... Keywords: ?-secretase, in silico drug design, ADMET screening, GOLD, GOLD score, HIPHOP, Lipinski's rule, acetylcholinesterase, blood-brain barrier, cholinesterase inhibitors, discovery studio, docking, pharmacophore modeling, protein data bank, virtual screening

Ankit Tyagi; Shikhar Gupta; C. Gopi Mohan

2010-02-01T23:59:59.000Z

390

Strategic Directions for Hydrogen Delivery Workshop Proceedings  

NLE Websites -- All DOE Office Websites (Extended Search)

W W W o o r r k k s s h h o o p p P P r r o o c c e e e e d d i i n n g g s s M M a a y y 7 7 - - 8 8 , , 2 2 0 0 0 0 3 3 C C r r y y s s t t a a l l C C i i t t y y M M a a r r r r i i o o t t t t A A r r l l i i n n g g t t o o n n , , V V A A S S p p o o n n s s o o r r e e d d b b y y U U . . S S . . D D e e p p a a r r t t m m e e n n t t o o f f E E n n e e r r g g y y O O f f f f i i c c e e o o f f E E n n e e r r g g y y E E f f f f i i c c i i e e n n c c y y a a n n d d R R e e n n e e w w a a b b l l e e E E n n e e r r g g y y O O f f f f i i c c e e o o f f H H y y d d r r o o g g e e n n , , F F u u e e l l C C e e l l l l s s , , a a n n d d I I n n f f r r a a s s t t r r u u c c t t u u r r e e T T e e c c h h n n o o l l o o g g i i e e s s P P r r o o g g r r a a m m Strategic Directions for Hydrogen Delivery Workshop i May 2003 Table of Contents INTRODUCTION ...........................................................................................................................................................................................1 BACKGROUND.............................................................................................................................................................................................1

391

Analysis of Assembly Bill 369: Prescription Drugs  

E-Print Network (OSTI)

health treatment; prescription drugs; rehabilitative and habilitative services and devices; laboratory

California Health Benefits Review Program (CHBRP)

2011-01-01T23:59:59.000Z

392

Bounding Radionuclide Inventory and Accident Consequence Calculation for the 1L Target  

Science Conference Proceedings (OSTI)

A bounding radionuclide inventory for the tungsten of the Los Alamos Neutron Science Center (LANSCE) IL Target is calculated. Based on the bounding inventory, the dose resulting from the maximum credible incident (MCI) is calculated for the maximally exposed offsite individual (MEOl). The design basis accident involves tungsten target oxidation following a loss of cooling accident. Also calculated for the bounding radionuclide inventory is the ratio to the LANSCE inventory threshold for purposes of inventory control as described in the target inventory control policy. A bounding radionuclide inventory calculation for the lL Target was completed using the MCNPX and CINDER'90 codes. Continuous beam delivery at 200 {micro}A to 2500 mA{center_dot}h was assumed. The total calculated activity following this irradiation period is 205,000 Ci. The dose to the MEOI from the MCI is 213 mrem for the bounding inventory. The LANSCE inventory control threshold ratio is 132.

Kelsey, Charles T. IV [Los Alamos National Laboratory

2011-01-01T23:59:59.000Z

393

Multiple target laser ablation system  

DOE Patents (OSTI)

A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

Mashburn, Douglas N. (Knoxville, TN)

1996-01-01T23:59:59.000Z

394

Inertial-confinement-fusion targets  

DOE Green Energy (OSTI)

Inertial confinement fusion (ICF) targets are made as simple flat discs, as hollow shells or as complicated multilayer structures. Many techniques have been devised for producing the targets. Glass and metal shells are made by using drop and bubble techniques. Solid hydrogen shells are also produced by adapting old methods to the solution of modern problems. Some of these techniques, problems and solutions are discussed. In addition, the applications of many of the techniques to fabrication of ICF targets is presented.

Hendricks, C.D.

1981-11-16T23:59:59.000Z

395

Electromagnetic Detection and Real-Time DMLC Adaptation to Target Rotation During Radiotherapy  

SciTech Connect

Purpose: Intrafraction rotation of more than 45 Degree-Sign and 25 Degree-Sign has been observed for lung and prostate tumors, respectively. Such rotation is not routinely adapted to during current radiotherapy, which may compromise tumor dose coverage. The aim of the study was to investigate the geometric and dosimetric performance of an electromagnetically guided real-time dynamic multileaf collimator (DMLC) tracking system to adapt to intrafractional tumor rotation. Materials/Methods: Target rotation was provided by changing the treatment couch angle. The target rotation was measured by a research Calypso system integrated with a real-time DMLC tracking system employed on a Varian linac. The geometric beam-target rotational alignment difference was measured using electronic portal images. The dosimetric accuracy was quantified using a two-dimensional ion chamber array. For each beam, the following five delivery modes were tested: 1) nonrotated target (reference); 2) fixed rotated target with tracking; 3) fixed rotated target without tracking; 4) actively rotating target with tracking; and 5) actively rotating target without tracking. Dosimetric performance of the latter four modes was measured and compared to the reference dose distribution using a 3 mm/3% {gamma}-test. Results: Geometrically, the beam-target rotational alignment difference was 0.3 Degree-Sign {+-} 0.6 Degree-Sign for fixed rotation and 0.3 Degree-Sign {+-} 1.3 Degree-Sign for active rotation. Dosimetrically, the average failure rate for the {gamma}-test for a fixed rotated target was 11% with tracking and 36% without tracking. The average failure rate for an actively rotating target was 9% with tracking and 35% without tracking. Conclusions: For the first time, real-time target rotation has been accurately detected and adapted to during radiation delivery via DMLC tracking. The beam-target rotational alignment difference was mostly within 1 Degree-Sign . Dose distributions to fixed and actively rotating targets with DMLC tracking were significantly superior to those without tracking.

Wu Junqing [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); School of Health Sciences, Purdue University, West Lafayette, IN (United States); Ruan, Dan [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); Cho, Byungchul [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); Asan Medical Center, Seoul (Korea, Republic of); Sawant, Amit [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); Petersen, Jay; Newell, Laurence J. [Calypso Medical Technologies, Seattle, WA (United States); Cattell, Herbert [Varian Medical Systems, Palo Alto, CA (United States); Keall, Paul J., E-mail: radphyslab@sydney.edu.au [Department of Radiation Oncology, Stanford University, Stanford, CA (United States); Radiation Physics Laboratory, Sydney Medical School, University of Sydney, Sydney (Australia)

2012-03-01T23:59:59.000Z

396

Drug Use and Drug Policy in a Prohibition Regime  

E-Print Network (OSTI)

Heroin/opiates MacCoun and Martin - 2/4/2008 - 41 Otherstory_268000326.html. MacCoun and Martin - 2/4/2008 - 29Toward a drugs MacCoun and Martin - 2/4/2008 - 32 and crime

MacCoun, Robert; Martin, Karin D.

2008-01-01T23:59:59.000Z

397

Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan  

Alternative Fuels and Advanced Vehicles Data Center (EERE)

Natural Gas Delivery Natural Gas Delivery Vans Support McShan Florist to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Twitter Bookmark Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Google Bookmark Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Delicious Rank Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Digg Find More places to share Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on AddThis.com... May 25, 2012 Natural Gas Delivery Vans Support McShan Florist W atch how a Dallas, Texas, florist reduces emissions and saves money

398

Oncor Electric Delivery - Government and Education Facilities Program |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Oncor Electric Delivery - Government and Education Facilities Oncor Electric Delivery - Government and Education Facilities Program Oncor Electric Delivery - Government and Education Facilities Program < Back Eligibility Institutional Local Government Schools Tribal Government Savings Category Home Weatherization Commercial Weatherization Heating & Cooling Commercial Heating & Cooling Cooling Other Construction Heat Pumps Appliances & Electronics Commercial Lighting Lighting Manufacturing Insulation Design & Remodeling Windows, Doors, & Skylights Program Info State Texas Program Type Utility Rebate Program Rebate Amount Chillers (Metro): $225.72/kW plus $0.07/kWh Chillers (Non-Metro): $219.82/kW plus $0.08/kWh DX HVAC (Metro): $191.15/kW plus $0.06/kWh DX HVAC (Non-Metro): $219.82/kW plus $0.07/kWh Geothermal (Metro): $251.45/kW plus $0.08/kWh

399

Oncor Electric Delivery - Large Commercial and Industrial Rebate Program |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Oncor Electric Delivery - Large Commercial and Industrial Rebate Oncor Electric Delivery - Large Commercial and Industrial Rebate Program Oncor Electric Delivery - Large Commercial and Industrial Rebate Program < Back Eligibility Commercial Construction Industrial Installer/Contractor Institutional Local Government Schools State Government Savings Category Heating & Cooling Commercial Heating & Cooling Cooling Manufacturing Other Heat Pumps Appliances & Electronics Commercial Lighting Lighting Home Weatherization Insulation Design & Remodeling Windows, Doors, & Skylights Solar Buying & Making Electricity Water Heating Wind Maximum Rebate General: 20% of the incentive budget in a given budget year Contact Oncor for additional details Program Info State Texas Program Type Utility Rebate Program Rebate Amount DX Air Conditioning: $285.30/kW; $0.09/kWh

400

Office of Electricity Delivery and Energy Reliability FY 2010 Budget |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FY 2010 FY 2010 Budget Office of Electricity Delivery and Energy Reliability FY 2010 Budget The FY 2010 Office of Electricity Delivery and Energy Reliability (OE) budget request is $208.0 million, $71.0 million more than the FY 2009 Appropriation. This increase reflects increased investments in research and development, particularly in energy storage, smart grid technologies, and cyber security areas. OE will also establish one of the Department's multi-disciplinary Energy Innovation Hubs (Hubs) that specifically focuses on Grid Materials, Devices, and Systems. The FY 2010 budget proposes a budget structure change to better align with the Department's priorities to establish a clean, secure energy future. Office of Electricity Delivery and Energy Reliability FY 2010 Budget

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

August 20, 2010 August 20, 2010 CX-003473: Categorical Exclusion Determination Pacific Northwest Smart Grid Demonstration CX(s) Applied: A1, A9, A11, B1.7, B4.4, B4.7, B4.11, B5.1 Date: 08/20/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory August 17, 2010 CX-003429: Categorical Exclusion Determination Oswego County BOCES Wind Turbine Model Project CX(s) Applied: A9, B1.15, B5.1 Date: 08/17/2010 Location(s): Mexico, New York Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory August 5, 2010 CX-003312: Categorical Exclusion Determination Power Grid Reliability and Security ? Phase II CX(s) Applied: A9, A11 Date: 08/05/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy

402

Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

SPR Oil to Marathon Petroleum Company SPR Oil to Marathon Petroleum Company Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of SPR Oil to Marathon Petroleum Company September 8, 2008 - 3:20pm Addthis WASHINGTON, DC - Today, September 8, 2008, the U.S. Department of Energy will deliver 250,000 barrels of oil from the Strategic Petroleum Reserve to Marathon Petroleum Company's Midwest refineries along the Capline pipeline system. The oil was requested by Marathon because of disruptions in supply caused by Hurricane Gustav. Media contact(s): Healy Baumgardner, (202) 586-4940 Addthis Related Articles Statement from DOE's Chief Spokesperson Andrew Beck Regarding Strategic Petroleum Reserve Oil Deliveries Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of

403

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

November 4, 2010 November 4, 2010 CX-004397: Categorical Exclusion Determination The Padlock Project CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 11/04/2010 Location(s): Pullman, Washington Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory October 27, 2010 CX-004331: Categorical Exclusion Determination Long Island Smart Energy Corridor CX(s) Applied: A1, A9, A11 Date: 10/27/2010 Location(s): Stony Brook, New York Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory October 27, 2010 CX-004330: Categorical Exclusion Determination Long Island Smart Energy Corridor CX(s) Applied: A9, A11, B3.6, B4.4, B5.1 Date: 10/27/2010 Location(s): Farmingdale, New York Office(s): Electricity Delivery and Energy Reliability, National Energy

404

Design-Build Project Delivery | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Design-Build Project Delivery Design-Build Project Delivery Design-Build Project Delivery October 16, 2013 - 4:46pm Addthis Renewable energy must be integrated into each of the design phases. Noting that any agency may have specific processes during the development of a construction project, this section discusses key issues in the following phases of the design-build process: Planning and Programming Request for Qualifications Request for Proposal Construction Contract Design and Build Integrating renewable energy into design-bid-build strategy involves a few different approaches, which are covered in the main building design section of this guide. Planning and Programming The planning and programming phase should look the same regardless of whether the project is design-bid-build or design-build. An early team is

405

Vectren Energy Delivery of Ohio (Gas) - Commercial Energy Efficiency  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Ohio (Gas) - Commercial Energy Ohio (Gas) - Commercial Energy Efficiency Rebates Vectren Energy Delivery of Ohio (Gas) - Commercial Energy Efficiency Rebates < Back Eligibility Commercial Industrial Savings Category Heating & Cooling Commercial Heating & Cooling Heating Other Commercial Weatherization Maximum Rebate Boilers: $5,000 Boiler Tune-Up: $250 Custom Incentives: 30% of the total project cost or $25,000/project Program Info State Ohio Program Type Utility Rebate Program Rebate Amount Boilers: 25% of cost Boiler Tune-Up: 50% of cost Furnace: $200 Programmable Thermostat: $20 Custom Incentives: $0.75/therm (less than 7500 therm savings) or $1/therm (greater than 7500 therm savings) calculated based on first year energy savings. Provider Vectren Energy Delivery of Ohio Vectren Energy Delivery offers commercial natural gas customers in Ohio

406

Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency Rebates Vectren Energy Delivery of Indiana (Gas) - Commercial Energy Efficiency Rebates < Back Eligibility Commercial Fed. Government Local Government Nonprofit State Government Savings Category Heating & Cooling Commercial Heating & Cooling Heating Other Commercial Weatherization Appliances & Electronics Water Heating Maximum Rebate Boilers: $5,000 Boiler Modulating Burner Control: $5,000 Infrared Heater: $700 Custom: Contact Vectren Program Info State Indiana Program Type Utility Rebate Program Rebate Amount Boilers: $4/MMbtu Boiler Modulating Burner Control: up to $5000 Boiler Reset Control or Tune-Up: $250 Boiler Tune-up: $200 Furnace: $150 - $275 Tank Water Heater: $125 - $150 Tankless Water Heater: $150

407

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

February 9, 2010 February 9, 2010 CX-000760: Categorical Exclusion Determination Amber Kinetics Flywheel Energy Storage Demonstration CX(s) Applied: B3.6 Date: 02/09/2010 Location(s): Freemont, California Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 8, 2010 CX-000762: Categorical Exclusion Determination Eastern Interconnection Planning Collaborative CX(s) Applied: A9 Date: 02/08/2010 Location(s): Morristown, Pennsylvania Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 8, 2010 CX-000764: Categorical Exclusion Determination Dynamic Line Rating Project CX(s) Applied: B3.11, B4.6 Date: 02/08/2010 Location(s): Texas Office(s): Electricity Delivery and Energy Reliability, National Energy

408

Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Deputy Secretary Poneman's Remarks at TERI - As Prepared for Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery Deputy Secretary Poneman's Remarks at TERI - As Prepared for Delivery July 18, 2011 - 6:15pm Addthis U.S. Deputy Secretary of Energy Daniel Poneman Remarks As Prepared for Delivery at TERI Monday, July 18, 2011 New Delhi, India Good morning. Thank you, Mr. Desai for the introduction. And thank you to TERI for hosting me this afternoon. I want to acknowledge the leadership TERI is already showing in advancing energy research and in fostering a constructive dialogue on issues that are critical to the people of India and to the world. We are grateful for your commitment and dedication, and for the work that you do every day. Before I begin my remarks today, I want to take a moment on behalf of the

409

Competition Advocates and Task-Order and Delivery Order Ombudsman |  

National Nuclear Security Administration (NNSA)

Competition Advocates and Task-Order and Delivery Order Ombudsman | Competition Advocates and Task-Order and Delivery Order Ombudsman | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Competition Advocates and Task-Order and Delivery Order Ombudsman Home > About Us > Our Operations > Acquisition and Project Management > Office of Acquisition Management (OAM) > Competition Advocates and

410

Computer modeling reveals how surprisingly potent hepatitis C drug works  

NLE Websites -- All DOE Office Websites (Extended Search)

Hepatitis C computer modeling Hepatitis C computer modeling Computer modeling reveals how surprisingly potent hepatitis C drug works A study reveals how daclatasvir targets one of its proteins and causes the fastest viral decline ever seen with anti-HCV drugs - within 12 hours of treatment. February 19, 2013 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

411

Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

March 28, 2012 March 28, 2012 Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C. 20585 OE Docket No. RRTT-IR-001 Submitted via email to: Lamont.Jackson@hq.doe.gov COMMENTS OF THE AMERICAN WIND ENERGY ASSOCIATION ON THE DEPARTMENT OF ENERGY'S REQUEST FOR INFORMATION RELATED TO THE PERMITTING OF TRANSMISSION LINES Dear Mr. Jackson, The American Wind Energy Association 1 (AWEA) appreciates the opportunity to provide comments to the Department of Energy's Office of Electricity Delivery and Energy Reliability (DOE) on its request for information

412

Hydrogen Permeability and Integrity of Hydrogen Delivery Pipelines  

NLE Websites -- All DOE Office Websites (Extended Search)

Permeability and Permeability and Integrity of Hydrogen Delivery Pipelines Z. Feng*, L.M. Anovitz*, J.G. Blencoe*, S. Babu*, and P. S. Korinko** * Oak Ridge National Laboratory * Savannah River National Laboratory August 30, 2005 2 OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY Partners and Collaborators * Oak Ridge National Laboratory - Project lead * Savannah River National Laboratory - Low H 2 pressure permeation test * Edison Welding Institute - Pipeline materials * Lincoln Electric Company - Welding electrode and weld materials for pipelines * Trans Canada - Commercial welding of pipelines and industry expectations * DOE Pipeline Working Group and Tech Team activities - FRP Hydrogen Pipelines - Materials Solutions for Hydrogen Delivery in Pipelines - Natural Gas Pipelines for Hydrogen Use

413

Tank Waste Feed Delivery System Readiness at the Hanford Site  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Audit Report Audit Report Tank Waste Feed Delivery System Readiness at the Hanford Site OAS-L-12-09 August 2012 Department of Energy Washington, DC 20585 August 23, 2012 MEMORANDUM FOR THE MANAGER, OFFICE OF RIVER PROTECTION FROM: David Sedillo, Director Western Audits Division Office of Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Tank Waste Feed Delivery System Readiness at the Hanford Site" BACKGROUND The Department of Energy's largest cleanup task involves the treatment, immobilization and disposal of 56 million gallons of hazardous and highly radioactive waste at the Hanford Site, located in Southeastern Washington State. As part of this effort, the Department is constructing

414

The amphiphilic self-assembling peptide EAK16-I as a potential hydrophobic drug carrier  

Science Conference Proceedings (OSTI)

It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is reported here to be able to stabilize ...

Jing Wang; Fushan Tang; Feng Li; Juan Lin; Yinghui Zhang; Linfang Du; Xiaojun Zhao

2008-01-01T23:59:59.000Z

415

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request  

NLE Websites -- All DOE Office Websites (Extended Search)

Office of Electricity Delivery & Energy Reliability FY 2012 Budget Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation Presentation by Patricia Hoffman of the Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request. OE's FY 2012 budget request represents a strong commitment to modernizing the grid and providing the reliable, affordable, and secure electric power needed to expand economic recovery enable sources Office of Electricity Delivery and Energy Reliability recovery, the transition to renewable energy sources, and achieve the President's clean energy goals. Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request Presentation More Documents & Publications

416

Luminosity Stability Issues for the TESLA Beam Delivery System (BDS)  

E-Print Network (OSTI)

Luminosity Stability Issues for the TESLA Beam Delivery System (BDS) Nicholas Walker1 (DESY, Germany) Andrzej Wolski2 (Daresbury Laboratory, UK) TESLA 2000-22 October 17, 2000 1 Introduction Given of ground motion and vibration in linear colliders both for TESLA and NLC/JLC (see for example [1

417

Evaluation of an information service for enhanced multiaccess media delivery  

Science Conference Proceedings (OSTI)

Multimedia delivery in mobile multiaccess network environments is gaining traction as a key area within the future Internet research domain. When network heterogeneity is coupled with the proliferation of multiaccess capabilities of mobile handheld devices, ... Keywords: event service, information service, mobility management, multiaccess

Jukka Mäkelä; Markus Luoto; Tiia Sutinen; Kostas Pentikousis

2009-09-01T23:59:59.000Z

418

Timely Delivery of Laser Inertial Fusion Energy Presentation prepared for  

E-Print Network (OSTI)

acceptability Timely delivery NIF-1210-20673s2.ppt · Pinnacle West Capital Corp · PG&E Corporation · Mid Generation · Exelon Generation Company · Southern California Edison Electric Power Utility needs NIF-0611 on direct evidence of fusion performance (NIF). · Use of available technology and materials that can

419

United Parcel Service Evaluates Hybrid Electric Delivery Vans (Fact Sheet)  

DOE Green Energy (OSTI)

This fact sheet describes how the National Renewable Energy Laboratory's Fleet Test and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans - fueled by regular diesel - and six comparable conventional diesel vans operated by the United Parcel Service.

Not Available

2010-02-01T23:59:59.000Z

420

A Hybrid Solution Approach for Ready-Mixed Concrete Delivery  

Science Conference Proceedings (OSTI)

Companies in the concrete industry are facing the following scheduling problem on a daily basis: Concrete produced at several plants has to be delivered at customers' construction sites using a heterogeneous fleet of vehicles in a timely, but cost-effective ... Keywords: hybrid approach, integer multicommodity flow, ready-mixed concrete delivery, variable neighborhood search

Verena Schmid; Karl F. Doerner; Richard F. Hartl; Martin W. P. Savelsbergh; Wolfgang Stoecher

2009-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Waste Feed Delivery Environmental Permits and Approvals Plan  

Science Conference Proceedings (OSTI)

This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

TOLLEFSON, K.S.

2000-01-18T23:59:59.000Z

422

Hydrogen Delivery Technologies and Pipeline Transmission of Hydrogen  

E-Print Network (OSTI)

Hydrogen Delivery Technologies and Systems Pipeline Transmission of Hydrogen Strategic Initiatives, and Infrastructure Technologies Program #12;Pipeline Transmission of Hydrogen --- 2 Copyright: Design & Operation Standards Relevant Design and Operating Standards ANSI/ASME B31.8 49 CFR 192 CGA H2 Pipeline Standard (in

423

A method of dose reconstruction for moving targets compatible with dynamic treatments  

SciTech Connect

Purpose: To develop a method that allows a commercial treatment planning system (TPS) to perform accurate dose reconstruction for rigidly moving targets and to validate the method in phantom measurements for a range of treatments including intensity modulated radiation therapy (IMRT), volumetric arc therapy (VMAT), and dynamic multileaf collimator (DMLC) tracking. Methods: An in-house computer program was developed to manipulate Dicom treatment plans exported from a TPS (Eclipse, Varian Medical Systems) such that target motion during treatment delivery was incorporated into the plans. For each treatment, a motion including plan was generated by dividing the intratreatment target motion into 1 mm position bins and construct sub-beams that represented the parts of the treatment that were delivered, while the target was located within each position bin. For each sub-beam, the target shift was modeled by a corresponding isocenter shift. The motion incorporating Dicom plans were reimported into the TPS, where dose calculation resulted in motion including target dose distributions. For experimental validation of the dose reconstruction a thorax phantom with a moveable lung equivalent rod with a tumor insert of solid water was first CT scanned. The tumor insert was delineated as a gross tumor volume (GTV), and a planning target volume (PTV) was formed by adding margins. A conformal plan, two IMRT plans (step-and-shoot and sliding windows), and a VMAT plan were generated giving minimum target doses of 95% (GTV) and 67% (PTV) of the prescription dose (3 Gy). Two conformal fields with MLC leaves perpendicular and parallel to the tumor motion, respectively, were generated for DMLC tracking. All treatment plans were delivered to the thorax phantom without tumor motion and with a sinusoidal tumor motion. The two conformal fields were delivered with and without portal image guided DMLC tracking based on an embedded gold marker. The target dose distribution was measured with a radiochromic film in the moving rod and compared with the reconstructed doses using gamma tests. Results: Considerable interplay effects between machine motion and target motion were observed for the treatments without tracking. For nontracking experiments, the mean 2 mm/2% gamma pass rate over all investigated scenarios was 99.6% between calculated and measured doses. For tracking experiments, the mean gamma pass rate was 99.4%. Conclusions: A method for accurate dose reconstruction for moving targets with dynamic treatments was developed and experimentally validated in a variety of delivery scenarios. The method is suitable for integration into TPSs, e.g., for reconstruction of the dose delivered to moving tumors or calculation of target doses delivered with DMLC tracking.

Rugaard Poulsen, Per; Lykkegaard Schmidt, Mai; Keall, Paul; Schjodt Worm, Esben; Fledelius, Walther; Hoffmann, Lone [Department of Oncology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Institute of Clinical Medicine, Aarhus University, Brendstrupgaardsvej 100, 8200 Aarhus N (Denmark); Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C (Denmark); Radiation Physics Laboratory, Sydney Medical School, University of Sydney, NSW 2006 (Australia); Department of Oncology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Department of Medical Physics, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark); Department of Oncology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark); Department of Medical Physics, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark)

2012-10-15T23:59:59.000Z

424

Process management applications in biopharmaceutical drug production  

E-Print Network (OSTI)

Genzyme's manufacturing and supply chain organization is responsible for the production and delivery of medically necessary medicines for patients with rare diseases around the world. Because of the nature of the products ...

Smith, Stephen E

2011-01-01T23:59:59.000Z

425

Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in  

Alternative Fuels and Advanced Vehicles Data Center (EERE)

Natural Gas Powers Natural Gas Powers Milk Delivery Trucks in Indiana to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Facebook Tweet about Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Twitter Bookmark Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Google Bookmark Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Delicious Rank Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Digg Find More places to share Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on AddThis.com... Aug. 20, 2011 Natural Gas Powers Milk Delivery Trucks in Indiana

426

DOE Hydrogen and Fuel Cells Program: 2007 Annual Progress Report - Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery Delivery Printable Version 2007 Annual Progress Report III. Delivery This section of the 2007 Progress Report for the DOE Hydrogen Program focuses on delivery. Each technical report is available as an individual Adobe Acrobat PDF. Download Adobe Reader. Hydrogen Delivery Sub-Program Overview, Mark Paster, U.S. Department of Energy (PDF 182 KB) A. Analysis Hydrogen Delivery Infrastructure Options Analysis, Tan-Ping Chen, Nexant, Inc. (PDF 620 KB) B. Liquefaction Innovative Hydrogen Liquefaction Cycle, Martin A. Shimko, Gas Equipment Engineering Corp. (PDF 514 KB) C. Carriers Reversible Liquid Carriers for an Integrated Production, Storage and Delivery of Hydrogen, Guido P. Pez, Air Products & Chemicals, Inc. (PDF 528 KB) D. Storage Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel

427

Apatite-Polymer Composite Particles for Controlled Delivery of BMP-2  

E-Print Network (OSTI)

We have developed a versatile delivery platform comprising a novel composite of two biomaterials with proven track records: apatite and poly(lactic-co-glycolic acid) (PLGA). These composites have been tested in the delivery ...

Yong, Tseh-Hwan

428

Understanding barriers to efficient nucleic acid delivery with bioresponsive block copolymers  

E-Print Network (OSTI)

The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have been held back by immunogenicity and toxicity ...

Bonner, Daniel Kenneth

2012-01-01T23:59:59.000Z

429

Cell squeezing : a vector-free microfluidic platform for intracellular delivery of macromolecules  

E-Print Network (OSTI)

Intracellular delivery of material is a long-standing challenge for both therapeutic and research applications. Existing technologies rely on a variety of mechanisms to facilitate delivery. Vector-based methods, such as ...

Sharei, Armon R. (Armon Reza)

2013-01-01T23:59:59.000Z

430

Abstract This research investigates the requirements for proactive service delivery for heavy industrial equipment  

E-Print Network (OSTI)

Abstract ­ This research investigates the requirements for proactive service delivery for heavy. Keywords: Service contract, heavy industrial equipment, proactive service delivery, reference model. 1 Introduction Manufacturers of heavy industry are increasingly expanding into the service sector, not just

Hsu, Cheng

431

Targeting NRF2 signaling for cancer chemoprevention  

SciTech Connect

Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

Kwak, Mi-Kyoung, E-mail: mkwak@ynu.ac.k [College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749 (Korea, Republic of); Kensler, Thomas W. [Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (United States)

2010-04-01T23:59:59.000Z

432

In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles  

E-Print Network (OSTI)

Cancer is the collective group of diseases distinguished by uninhibited growth and spread of abnormal cells. It often results in death if the spread is not controlled. Most cancers are treated by surgery, radiation, ...

Miller, Michelle Teresa

2009-01-01T23:59:59.000Z

433

Countdown to Fixed Target INSIDE  

NLE Websites -- All DOE Office Websites (Extended Search)

17, 1996 17, 1996 Number 10 Countdown to Fixed Target INSIDE 2 University Close-Up: The University of Illinois 4 Tollestrup Elected to National Academy 5 Bardeen Receives Sakurai Prize 6 Take Your Daughters and Sons to Work Day "At this moment," Fermilab Director John Peoples told the House Subcommittee on Energy and Environment in testimony deliv- ered in Washington on May 8, "Fermilab is in the midst of the transition from collider opera- tions to fixed-target operations. In June, we will begin extracting a beam of protons from the Tevatron, the highest-energy external beam in the world. By directing this beam onto eight targets we will create eight distinct particle beams that will in turn support 10 unique experiments. Although fixed-target experi- ments cannot explore the high-energy frontier

434

Multiple agents moving target search  

Science Conference Proceedings (OSTI)

Traditional single-agent search algorithms usually make simplifying assumptions (single search agent, stationary target, complete knowledge of the state, and sufficient time). There are algorithms for relaxing one or two of these constraints; in this ...

Mark Goldenberg; Alexander Kovarsky; Xiaomeng Wu; Jonathan Schaeffer

2003-08-01T23:59:59.000Z

435

Targeted Advertising ... And Privacy Too  

Science Conference Proceedings (OSTI)

The Web presents a rich and powerful tool for aggregation of consumer information. A flurry of recent articles in the popular press has documented aggressive manipulation of such information by some companies for the purposes of targeted advertising. ...

Ari Juels

2001-04-01T23:59:59.000Z

436

Improving translation via targeted paraphrasing  

Science Conference Proceedings (OSTI)

Targeted paraphrasing is a new approach to the problem of obtaining cost-effective, reasonable quality translation that makes use of simple and inexpensive human computations by monolingual speakers in combination with machine translation. The key insight ...

Philip Resnik; Olivia Buzek; Chang Hu; Yakov Kronrod; Alex Quinn; Benjamin B. Bederson

2010-10-01T23:59:59.000Z

437

The dosimetric impact of inversely optimized arc radiotherapy plan modulation for real-time dynamic MLC tracking delivery  

SciTech Connect

Purpose: Real-time dynamic multileaf collimator (MLC) tracking for management of intrafraction tumor motion can be challenging for highly modulated beams, as the leaves need to travel far to adjust for target motion perpendicular to the leaf travel direction. The plan modulation can be reduced by using a leaf position constraint (LPC) that reduces the difference in the position of adjacent MLC leaves in the plan. The purpose of this study was to investigate the impact of the LPC on the quality of inversely optimized arc radiotherapy plans and the effect of the MLC motion pattern on the dosimetric accuracy of MLC tracking delivery. Specifically, the possibility of predicting the accuracy of MLC tracking delivery based on the plan modulation was investigated. Methods: Inversely optimized arc radiotherapy plans were created on CT-data of three lung cancer patients. For each case, five plans with a single 358 deg. arc were generated with LPC priorities of 0 (no LPC), 0.25, 0.5, 0.75, and 1 (highest possible LPC), respectively. All the plans had a prescribed dose of 2 Gy x 30, used 6 MV, a maximum dose rate of 600 MU/min and a collimator angle of 45 deg. or 315 deg. To quantify the plan modulation, an average adjacent leaf distance (ALD) was calculated by averaging the mean adjacent leaf distance for each control point. The linear relationship between the plan quality [i.e., the calculated dose distributions and the number of monitor units (MU)] and the LPC was investigated, and the linear regression coefficient as well as a two tailed confidence level of 95% was used in the evaluation. The effect of the plan modulation on the performance of MLC tracking was tested by delivering the plans to a cylindrical diode array phantom moving with sinusoidal motion in the superior-inferior direction with a peak-to-peak displacement of 2 cm and a cycle time of 6 s. The delivery was adjusted to the target motion using MLC tracking, guided in real-time by an infrared optical system. The dosimetric results were evaluated using gamma index evaluation with static target measurements as reference. Results: The plan quality parameters did not depend significantly on the LPC (p {>=} 0.066), whereas the ALD depended significantly on the LPC (p < 0.001). The gamma index failure rate depended significantly on the ALD, weighted to the percentage of the beam delivered in each control point of the plan (ALD{sub w}) when MLC tracking was used (p < 0.001), but not for delivery without MLC tracking (p {>=} 0.342). The gamma index failure rate with the criteria of 2% and 2 mm was decreased from > 33.9% without MLC tracking to <31.4% (LPC 0) and <2.2% (LPC 1) with MLC tracking. Conclusions: The results indicate that the dosimetric robustness of MLC tracking delivery of an inversely optimized arc radiotherapy plan can be improved by incorporating leaf position constraints in the objective function without otherwise affecting the plan quality. The dosimetric robustness may be estimated prior to delivery by evaluating the ALD{sub w} of the plan.

Falk, Marianne; Larsson, Tobias; Keall, Paul; Chul Cho, Byung; Aznar, Marianne; Korreman, Stine; Poulsen, Per; Munck af Rosenschoeld, Per [Radiation Medicine Research Center, Department of Radiation Oncology - 3994, Rigshospitalet, Blegdamsvej 9, DK - 2100 Copenhagen (Denmark) and Niels Bohr Institute, University of Copenhagen (Denmark); Radiation Medicine Research Center, Department of Radiation Oncology, Rigshospitalet, Copenhagen University Hospital (Denmark); Radiation Physics Laboratory, Sydney Medical School, University of Sydney (Australia); Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Radiation Medicine Research Center, Department of Radiation Oncology, Rigshospitalet, Copenhagen University Hospital, Denmark and Niels Bohr Institute, University of Copenhagen (Denmark); Radiation Medicine Research Center, Department of Radiation Oncology, Rigshospitalet, Copenhagen University Hospital (Denmark); Niels Bohr Institute, University of Copenhagen (Denmark) and Department of Science, Systems and Models, Roskilde University (Denmark); Department of Oncology, Aarhus University Hospital (Denmark); Radiation Medicine Research Center, Department of Radiation Oncology, Rigshospitalet, Copenhagen University Hospital (Denmark) and Niels Bohr Institute, University of Copenhagen (Denmark)

2012-03-15T23:59:59.000Z

438

Project Startup: Evaluating Coca-Cola's Class 8 Hybrid-Electric Delivery Trucks (Fact Sheet)  

DOE Green Energy (OSTI)

Fact sheet describing the project startup for evaluating Coca-Cola's Class 8 hybrid-electric delivery trucks.

Not Available

2011-03-01T23:59:59.000Z

439

Secretary Steven Chu Remarks as Prepared for Delivery to the 2011 IAEA General Conference  

Energy.gov (U.S. Department of Energy (DOE))

2011 IAEA General ConferenceRemarks as Prepared for DeliverySecretary Steven ChuMonday, September 19, 2011

440

South Carolina Kerosene-Type Jet Fuel All Sales/Deliveries by ...  

U.S. Energy Information Administration (EIA)

South Carolina Kerosene-Type Jet Fuel All Sales/Deliveries by Prime Supplier (Thousand Gallons per Day)

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

South Dakota No 2 Fuel Oil / Heating Oil Adj Sales/Deliveries to ...  

U.S. Energy Information Administration (EIA)

South Dakota No 2 Fuel Oil / Heating Oil Adj Sales/Deliveries to Commercial Consumers (Thousand Gallons)

442

National Ignition Facility Target Chamber  

DOE Green Energy (OSTI)

On June 11, 1999 the Department of Energy dedicated the single largest piece of the National Ignition Facility (NIF) at Lawrence Livermore National Laboratory (LLNL) in Livermore, California. The ten (10) meter diameter aluminum target high vacuum chamber will serve as the working end of the largest laser in the world. The output of 192 laser beams will converge at the precise center of the chamber. The laser beams will enter the chamber in two by two arrays to illuminate 10 millimeter long gold cylinders called hohlraums enclosing 2 millimeter capsule containing deuterium, tritium and isotopes of hydrogen. The two isotopes will fuse, thereby creating temperatures and pressures resembling those found only inside stars and in detonated nuclear weapons, but on a minute scale. The NIF Project will serve as an essential facility to insure safety and reliability of our nation's nuclear arsenal as well as demonstrating inertial fusion's contribution to creating electrical power. The paper will discuss the requirements that had to be addressed during the design, fabrication and testing of the target chamber. A team from Sandia National Laboratories (SNL) and LLNL with input from industry performed the configuration and basic design of the target chamber. The method of fabrication and construction of the aluminum target chamber was devised by Pitt-Des Moines, Inc. (PDM). PDM also participated in the design of the chamber in areas such as the Target Chamber Realignment and Adjustment System, which would allow realignment of the sphere laser beams in the event of earth settlement or movement from a seismic event. During the fabrication of the target chamber the sphericity tolerances had to be addressed for the individual plates. Procedures were developed for forming, edge preparation and welding of individual plates. Construction plans were developed to allow the field construction of the target chamber to occur parallel to other NIF construction activities. This was necessary to achieve the overall schedule. Plans had to be developed for the precise location and alignment of laser beam ports. Upon completion of the fabrication of the aluminum target chamber in a temporary structure the 130 ton sphere was moved from the temporary construction enclosure to its final location in the target building. Prior to the installation of a concrete shield and after completion of the welding of the chamber penetrations vacuum leak checking was performed to insure the vacuum integrity of target chamber. The entire spherical chamber external surface supports a 40 cm thick reinforced concrete shield after installation in the target building. The final task is a total survey of the laser ports and the contour machining of spacer plates so that laser devices attached to these ports meet the alignment criteria.

Wavrik, R W; Cox, J R; Fleming, P J

2000-10-05T23:59:59.000Z

443

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel...

444

The pipeline and future of drug development in schizophrenia  

E-Print Network (OSTI)

The Pipeline and Future of Drug Development in SchizophreniaThe Drug Discovery Pipeline in Schizophrenia Keywords:discuss the current pipeline of drugs for schizophrenia,

Gray, J A; Roth, B L

2007-01-01T23:59:59.000Z

445

ChemCam laser sets its sights on first martian target  

NLE Websites -- All DOE Office Websites (Extended Search)

First martian target First martian target ChemCam laser sets its sights on first martian target The successful capture of ChemCam's first 10 photos sets the stage for the first test bursts of the instrument's rock-zapping laser in the near future. August 17, 2012 Curiosity zaps Mars for vital signs: ChemCam, designed by Lab team, looks for elements such as carbon, nitrogen, and oxygen, all of which are crucial for life. Curiosity zaps Mars for vital signs: ChemCam, designed by Lab team, looks for elements such as carbon, nitrogen, and oxygen, all of which are crucial for life. Contact James E. Rickman Communications Office (505) 665-9203 Email "The successful delivery of these photos means we can begin efforts in earnest for the first images of Mars rocks by the ChemCam instrument and

446

The Production and Delivery of an Inertial Fusion Energy Power Plant Fuel - The Cryogenic Target (A25529)  

E-Print Network (OSTI)

Proc. Of 24th Symposium On Fusion Technology, Warsaw, Poland (2006), To Be Published In Fusion Eng, And Design24th Symposium on Fusion Technology Warsaw, pl, 2006999612525

Bozek, A.S.

2006-09-01T23:59:59.000Z

447

Cellular delivery and site-specific targeting of organic fluorophores for super-resolution imaging in living cells  

E-Print Network (OSTI)

Recent advances in super-resolution fluorescence microscopy have pushed the spatial resolution of biological imaging down to a few nanometers. The key element to the development of such imaging modality is synthetic organic ...

Uttamapinant, Chayasith

2013-01-01T23:59:59.000Z

448

Finding the 3-D Structure of a Key Drug Target for Diabetes ...  

NLE Websites -- All DOE Office Websites (Extended Search)

Cool Muscles: Storing Elastic Energy for Flight A Further Understanding of Superconductivity New Family of Tiny Crystals Glow Bright in LED Lights Science Highlights...

449

Phosphoinositide 3-kinases as drug targets in cancer Len Stephens1  

E-Print Network (OSTI)

, particularly, in the control of proliferation, survival and regulation of the potential oncogene PKB, with several additional PI3K effectors controlling cell proliferation and apoptosis having been described of the activity of a gene, a potential onco- gene, that favours survival, growth and/or proliferation. This can

Williams, Roger L.

450

Targets and methods for target preparation for radionuclide production  

DOE Patents (OSTI)

The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti--Sb, Al--Sb, Cu--Sb, or Ni--Sb in order to produce radionuclides (e.g., tin-117 m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.

Zhuikov, Boris L; Konyakhin, Nicolai A; Kokhanyuk, Vladimir M; Srivastava, Suresh C

2012-10-16T23:59:59.000Z

451

Layered double hydroxides as supports for intercalation and sustained release of antihypertensive drugs  

SciTech Connect

Zn/Al layered double hydroxides (LDHs) were intercalated with the anionic antihypertensive drugs Enalpril, Lisinopril, Captopril and Ramipril by using coprecipitation or ion-exchange technique. TG-MS analyses suggested that the thermal stability of Ena{sup -}, Lis{sup -} (arranged with monolayer, resulted from X-ray diffraction (XRD) and Fourier transform infrared spectra (FT-IR) analysis was enhanced much more than Cap{sup -} and Ram{sup -} (arranged with bilayer). The release studies show that the release rate of all samples markedly decreased in both pH 4.25 and 7.45. However, the release time of Ena{sup -}, Lis{sup -} were much longer compared with Cap{sup -}, Ram{sup -} in both pH 4.25 and 7.45, it is possible that the intercalated guests, arranged with monolayer in the interlayer, show lesser repulsive force and strong affinity with the LDH layers. And the release data followed both the Higuchi-square-root law and the first-order equation well. Based on the analysis of batch release, intercalated structural models as well as the TG-DTA results, we conclude that for drug-LDH, stronger the affinity between intercalated anions and the layers is, better the thermal property and the stability to the acid attack of drug-LDH, and the intercalated anions are easier apt to monolayer arrangement within the interlayer, were presented. - Graphical abstract: A series of antihypertensive drugs including Enalpril, Lisinopril, Captopril and Ramipril were intercalated into Zn/Al-NO{sub 3}-LDHs successfully by coprecipitation or ion-exchange technique. We focus on the structure, thermal property and low/controlled release property of as-synthesized drug-LDH composite intended for the possibility of applying these LDH-antihypertensive nanohybrids in drug delivery and controlled release systems.

Xia Shengjie [College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032 (China); Ni Zheming [College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032 (China)], E-mail: jchx@zjut.edu.cn; Xu Qian; Hu Baoxiang; Hu Jun [College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032 (China)

2008-10-15T23:59:59.000Z

452

Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Strategic Petroleum Reserve Oil Strategic Petroleum Reserve Oil Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of Strategic Petroleum Reserve Oil September 14, 2008 - 3:43pm Addthis WASHINGTON - The U.S. Department of Energy has agreed to deliver 200,000 barrels of emergency exchange oil from the Strategic Petroleum Reserve to ConocoPhillips Company's Wood River refinery along the Capline pipeline system. The Department will also deliver an additional 109,000 barrels of emergency exchange oil from the Strategic Petroleum Reserve to Placid Oil's Port Allen refinery along a Shell pipeline in Louisiana. The oil was requested by ConocoPhillips and Placid Oil because of disruptions in supply caused by Hurricanes Gustav and Ike. The deliveries will begin today. Media contact(s):

453

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

May 10, 2010 May 10, 2010 CX-002355: Categorical Exclusion Determination Kansas City Power and Light (KCP&L) Green Impact Zone Smart Grid Demonstration CX(s) Applied: B4.6, A1, A9, A11, B1.7, B4.11, B5.1 Date: 05/10/2010 Location(s): Kansas City, Missouri Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory May 10, 2010 CX-002353: Categorical Exclusion Determination Research and Development of a Silicon Carbide Fault Current Limiter (SSFCL) CX(s) Applied: B3.6 Date: 05/10/2010 Location(s): Fayetteville, Arkansas Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory April 22, 2010 CX-001701: Categorical Exclusion Determination Topic B - Cooperation on Electric Resource Planning and Priorities

454

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

July 13, 2010 July 13, 2010 CX-003028: Categorical Exclusion Determination Recovery Act - Fault Current Limiting Superconducting Transformer CX(s) Applied: A9, B3.6, B4.11 Date: 07/13/2010 Location(s): Oak Ridge, Tennessee Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory July 13, 2010 CX-003034: Categorical Exclusion Determination Pacific Northwest Smart Grid Demonstration CX(s) Applied: A1, A9, A11, B1.7, B4.4, B5.1 Date: 07/13/2010 Location(s): Helena, Montana Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory July 1, 2010 CX-002833: Categorical Exclusion Determination Pacific Northwest Smart Grid Demonstration CX(s) Applied: B3.6, B4.4, A1, A9, A11, B1.7, B5.1 Date: 07/01/2010 Location(s): Salem, Oregon

455

Categorical Exclusion Determinations: Office of Electricity Delivery and  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

February 24, 2011 February 24, 2011 CX-005326: Categorical Exclusion Determination Boeing Distribution Management System (BDMS) CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 02/24/2011 Location(s): Hazelwood, Missouri Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 24, 2011 CX-005325: Categorical Exclusion Determination Boeing Distribution Management System (BDMS) CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 02/24/2011 Location(s): Oak Brook Terrace, Illinois Office(s): Electricity Delivery and Energy Reliability, National Energy Technology Laboratory February 24, 2011 CX-005324: Categorical Exclusion Determination Boeing Distribution Management System (BDMS) CX(s) Applied: A1, A9, A11, B1.2, B1.7 Date: 02/24/2011 Location(s): Fort Collins, Colorado

456

Understanding High-Power Fiber-Optic Laser Beam Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

High-Power Fiber-Optic Laser Beam Delivery High-Power Fiber-Optic Laser Beam Delivery The submitted manuscript has been authored by a contractor of the U.S. Government under contract No. W- 31-109-ENG-38. Accordingly, the U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes. Boyd V. Hunter and Keng H. Leong Argonne National Laboratory Technology Development Division Laser Applications Laboratory 9700 South Cass Avenue, Building 207 Argonne, Illinois 60439 Carl B. Miller, James F. Golden, Robert D. Glesias and Patrick J. Laverty U. S. Laser Corporation 825 Windham Court North P. O. Box 609 Wyckoff, New Jersey 07481 March 25, 1996 Manuscript to be submitted to Journal of Laser Applications

457

Urban Sewage Delivery Heat Transfer System (2): Heat Transfer  

E-Print Network (OSTI)

The thimble delivery heat-transfer (TDHT) system is one of the primary modes to utilize the energy of urban sewage. Using the efficiency-number of transfer units method ( ), the heat-transfer efficiencies of the parallel-flow and reverse-flow TDTH forms are analyzed and the calculation formulas and characteristic are also given. The results indicate that the efficiency of the parallel-flow form is greater than that of the reverse-flow, so the TDTH system must choose the parallel-flow form. The distance-load ratio (DLR) is defined and the minimum DLR is obtained by the technical and economic feasibility analysis. The paper will provide references for heat-transfer calculation and schematic determination of urban sewage cool or heat source applied delivery heat transfer methods.

Zhang, C.; Wu, R.; Li, X.; Li, G.; Zhuang, Z.; Sun, D.

2006-01-01T23:59:59.000Z

458

Oncor Electric Delivery Company LLC | Open Energy Information  

Open Energy Info (EERE)

Oncor Electric Delivery Company LLC Oncor Electric Delivery Company LLC Place Texas Service Territory Texas Website www.oncor.com/EN/Pages/de Green Button Landing Page www.smartmetertexas.com/C Green Button Reference Page www.emeter.com/smart-grid Green Button Implemented Yes Utility Id 44372 Utility Location Yes Ownership I NERC Location TRE NERC ERCOT Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Buying Distribution Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Metered Facilities - Company-Owned (Closed to new installations) Lighting

459

Cyber Security Procurement Methodology for Power Delivery Systems  

Science Conference Proceedings (OSTI)

Determining how to apply cyber security requirements for new power delivery systems requires cyber security experts, power system engineers, and procurement organizations to work together with vendors to implement and maintain cyber security controls. Improper or incomplete implementation of controls due to lack of proper requirements and/or division of responsibilities between the utility and vendor can often result in costly backfit to meet requirements.The Electric Power Research ...

2012-12-31T23:59:59.000Z

460

Vision for a Holistic Power Supply and Delivery Chain  

Science Conference Proceedings (OSTI)

The dramatic changes that are likely to occur in the electric power industry in the next 10 years are inextricably linked to the activities of power system operators and planners. This report describes the necessary enhancements to the power delivery infrastructure as well as the tools and methods personnel will need to improve economic efficiency, assure adequate reliability and acceptable environmental impacts, increase system robustness and flexibility to mitigate extreme events, protect and leverage ...

2009-02-06T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Natural Gas Distributed Resource Fuel Pressure and Delivery Issues  

Science Conference Proceedings (OSTI)

Many emerging distributed resource (DR) technologies will be developed to operate on natural gas. However, increased reliance on natural gas as an energy source raises issues with regard to its availability and delivery capacity. In addition, some DR technologies may require specific pressure levels to operate properly. This report discusses the natural gas distribution infrastructure as well as the availability and suitability of DR gas booster technologies.

2000-10-17T23:59:59.000Z

462

Framework for Grading Procurement Requirements for Power Delivery Systems  

Science Conference Proceedings (OSTI)

Determining how to apply cyber security requirements for new power delivery systems requires cyber security experts, power system engineers, and procurement organizations to work together with vendors to select, implement, and maintain cyber security controls. Improper or incomplete implementations of security controls due to a lack of adequate requirements and/or division of responsibilities between the utility and vendor can often result in costly back fit to meet requirements.This ...

2013-11-27T23:59:59.000Z

463

Power Delivery System and Electricity Markets for the Future  

Science Conference Proceedings (OSTI)

This report is in draft form pending approval by EPRI Power Delivery & Markets Group Council. Upon approval, the report will be reformatted and issued as a final report by October 31, 2003. The Electricity Roadmap Initiative is an ongoing collaborative exploration of the opportunities for electricity-based innovation over the next 20 years and beyond. Thus far, over 150 organizations have participated with EPRI and its members in shaping a comprehensive vision of how to further increase electricity's val...

2003-08-27T23:59:59.000Z

464

Strategic Intelligence Update: Superconductivity for Power Delivery Applications, April 2013  

Science Conference Proceedings (OSTI)

EPRI’s Strategic Intelligence Update: Superconductivity for Power Delivery Applications newsletter is part of its commitment to keep its members informed on the latest industry news and intelligence. Superconductivity is a rapidly evolving field, and this newsletter—along with EPRI’s annual Technology Watch reports—will closely follow developments in key technologies, R&D programs, demonstrations, deployments, and other superconductivity activities. The ...

2013-04-30T23:59:59.000Z

465

Framework for Evaluating Cyber Security Posture for Power Delivery Systems  

Science Conference Proceedings (OSTI)

While many asset owners and operators are performing self-assessments of their control systems, the methods used vary widely across the electric sector. This lack of consistent criteria and metrics makes it difficult to benchmark and compare the cyber security posture of power delivery systems.The objective of this technical update is to develop an evaluation framework that uses both the Department of Energy (DOE) Electricity Subsector Cybersecurity Capability Maturity Model (ES-C2M2) ...

2013-11-28T23:59:59.000Z

466

Feasibility Study: Ductless Hydronic Distribution Systems with Fan Coil Delivery  

SciTech Connect

The primary objectives of this study are to estimate potential energy savings relative to conventional ducted air distribution, and to identify equipment requirements, costs, and barriers with a focus on ductless hydronic delivery systems that utilize water-to-air terminal units in each zone. Results indicate that annual heating and cooling energy use can be reduced by up to 27% assuming replacement of the conventional 13 SEER heat pump and coil with a similarly rated air-to-water heat pump.

Springer, D.; Dakin, B.; Backman, C.

2012-07-01T23:59:59.000Z

467

Experimental investigation of a moving averaging algorithm for motion perpendicular to the leaf travel direction in dynamic MLC target tracking  

SciTech Connect

Purpose: In dynamic multileaf collimator (MLC) motion tracking with complex intensity-modulated radiation therapy (IMRT) fields, target motion perpendicular to the MLC leaf travel direction can cause beam holds, which increase beam delivery time by up to a factor of 4. As a means to balance delivery efficiency and accuracy, a moving average algorithm was incorporated into a dynamic MLC motion tracking system (i.e., moving average tracking) to account for target motion perpendicular to the MLC leaf travel direction. The experimental investigation of the moving average algorithm compared with real-time tracking and no compensation beam delivery is described. Methods: The properties of the moving average algorithm were measured and compared with those of real-time tracking (dynamic MLC motion tracking accounting for both target motion parallel and perpendicular to the leaf travel direction) and no compensation beam delivery. The algorithm was investigated using a synthetic motion trace with a baseline drift and four patient-measured 3D tumor motion traces representing regular and irregular motions with varying baseline drifts. Each motion trace was reproduced by a moving platform. The delivery efficiency, geometric accuracy, and dosimetric accuracy were evaluated for conformal, step-and-shoot IMRT, and dynamic sliding window IMRT treatment plans using the synthetic and patient motion traces. The dosimetric accuracy was quantified via a {gamma}-test with a 3%/3 mm criterion. Results: The delivery efficiency ranged from 89 to 100% for moving average tracking, 26%-100% for real-time tracking, and 100% (by definition) for no compensation. The root-mean-square geometric error ranged from 3.2 to 4.0 mm for moving average tracking, 0.7-1.1 mm for real-time tracking, and 3.7-7.2 mm for no compensation. The percentage of dosimetric points failing the {gamma}-test ranged from 4 to 30% for moving average tracking, 0%-23% for real-time tracking, and 10%-47% for no compensation. Conclusions: The delivery efficiency of moving average tracking was up to four times higher than that of real-time tracking and approached the efficiency of no compensation for all cases. The geometric accuracy and dosimetric accuracy of the moving average algorithm was between real-time tracking and no compensation, approximately half the percentage of dosimetric points failing the {gamma}-test compared with no compensation.

Yoon, Jai-Woong; Sawant, Amit; Suh, Yelin; Cho, Byung-Chul; Suh, Tae-Suk; Keall, Paul [Department of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, Korea 131-700 and Research Institute of Biomedical Engineering, Catholic University of Korea, Seoul, 131-700 (Korea, Republic of); Department of Radiation Oncology, Stanford University, Stanford, California 94305 (United States); Department of Radiation Oncology, Stanford University, Stanford, California 94305 (United States) and Department of Radiation Oncology, Asan Medical Center, Seoul, 138-736 (Korea, Republic of); Department of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 131-700 and Research Institute of Biomedical Engineering, Catholic University of Korea, Seoul, 131-700 (Korea, Republic of); Department of Radiation Oncology, Stanford University, Stanford, California 94305 (United States) and Radiation Physics Laboratory, Sydney Medical School, University of Sydney, 2006 (Australia)

2011-07-15T23:59:59.000Z

468

Alaska Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)  

Gasoline and Diesel Fuel Update (EIA)

Exports (No Intransit Deliveries) (Million Cubic Feet) Exports (No Intransit Deliveries) (Million Cubic Feet) Alaska Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 49,861 52,857 52,840 52,883 50,172 48,599 51,573 51,424 1990's 52,546 54,005 52,532 55,989 62,682 65,283 67,648 62,187 65,951 63,607 2000's 65,610 65,753 63,439 65,698 62,099 65,124 60,765 48,396 39,164 30,536 2010's 30,100 16,398 9,342 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 1/7/2014 Next Release Date: 1/31/2014 Referring Pages: U.S. Natural Gas Exports Alaska U.S. Natural Gas Imports & Exports Natural Gas Exports (Summary)

469

Michigan Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)  

Gasoline and Diesel Fuel Update (EIA)

Exports (No Intransit Deliveries) (Million Cubic Feet) Exports (No Intransit Deliveries) (Million Cubic Feet) Michigan Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 0 0 0 0 9,113 3,257 17,900 38,361 1990's 17,284 14,751 67,763 44,413 49,470 26,948 50,363 56,447 39,683 36,998 2000's 70,980 161,588 171,515 259,597 368,947 337,818 317,291 455,216 531,333 673,318 2010's 721,075 876,267 872,620 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 1/7/2014 Next Release Date: 1/31/2014 Referring Pages: U.S. Natural Gas Exports Michigan U.S. Natural Gas Imports & Exports Natural Gas Exports

470

Arizona Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)  

Gasoline and Diesel Fuel Update (EIA)

Exports (No Intransit Deliveries) (Million Cubic Feet) Exports (No Intransit Deliveries) (Million Cubic Feet) Arizona Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 1,694 1,646 1,757 1,813 1,525 1,757 1,905 1,469 1990's 1,676 1,597 2,565 3,253 2,459 42 3,405 3,901 4,166 4,279 2000's 9,099 8,452 11,257 10,840 7,544 7,376 15,720 16,207 46,581 44,152 2010's 44,693 45,086 46,385 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 1/7/2014 Next Release Date: 1/31/2014 Referring Pages: U.S. Natural Gas Exports Arizona U.S. Natural Gas Imports & Exports Natural Gas Exports (Summary

471

Public Sector Procurement: Issues in Program Development & Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Public Sector Procurement: Issues in Program Development & Delivery Public Sector Procurement: Issues in Program Development & Delivery Title Public Sector Procurement: Issues in Program Development & Delivery Publication Type Report LBNL Report Number LBNL-6015E Year of Publication 2012 Authors Payne, Christopher T., and Andrew Weber Publisher LBNL Abstract The primary intention of this document is to illustrate the key issues and considerations made during the course of implementing a sustainable procurement program. Our primary sources of information have been our partners in the Super Efficient Equipment and Appliance Deployment (SEAD) Initiative Procurement Working Group. Where applicable, we have highlighted specific ways in which working group participants have successfully overcome these barriers. It is our hope that the issues discussed in this book will benefit developed and developing programs alike. In countries with less developed sustainable procurement programs, we hope that the discussions contained in the document will aid in the planning process. In addition, we hope that consideration of some of these key issues in the beginning stages of program implementation will help avoid some of the pitfalls experienced by more mature programs. In the case of more developed programs, we hope this book will spur conversation among those responsible for administering and evaluating sustainable procurement programs. In many cases, developed programs are seeking to improve existing processes and develop more effective purchaser resources.

472

Materials considerations in accelerator targets  

Science Conference Proceedings (OSTI)

Future nuclear materials production and/or the burn-up of long lived radioisotopes may be accomplished through the capture of spallation produced neutrons in accelerators. Aluminum clad-lead and/or lead alloys has been proposed as a spallation target. Aluminum was the cladding choice because of the low neutron absorption cross section, fast radioactivity decay, high thermal conductivity, and excellent fabricability. Metallic lead and lead oxide powders were considered for the target core with the fabrication options being casting or powder metallurgy (PM). Scoping tests to evaluate gravity casting, squeeze casting, and casting and swaging processes showed that, based on fabricability and heat transfer considerations, squeeze casting was the preferred option for manufacture of targets with initial core cladding contact. Thousands of aluminum clad aluminum-lithium alloy core targets and control rods for tritium production have been fabricated by coextrusion processes and successfully irradiated in the SRS reactors. Tritium retention in, and release from the coextruded product was modeled from experimental and operational data. Newly produced tritium atoms were trapped by lithium atoms to form a lithium tritide. The effective tritium pressure required for trap or tritide stability was the equilibrium decomposition pressure of tritium over a lithium tritide-aluminum mixture. The temperature dependence of tritium release was determined by the permeability of the cladding to tritium and the local equilibrium at the trap sites. The model can be used to calculate tritium release from aluminum clad, aluminum-lithium alloy targets during postulated accelerator operational and accident conditions. This paper describes the manufacturing technologies evaluated and presents the model for tritium retention in aluminum clad, aluminum-lithium alloy tritium production targets.

Peacock, H.B. Jr.; Iyer, N.C.; Louthan, M.R. Jr. [Westinghouse Savannah River Co., Aiken, SC (United States). Materials Technology Section

1994-08-01T23:59:59.000Z

473

Tracking highly maneuverable targets with unknown behavior  

E-Print Network (OSTI)

for maneuvering target tracking,” IEEE Trans. Aerosp.converted measurements for tracking,” IEEE Trans. Aerosp.particle filters for tracking a maneuvering target,” in

Schell, C; Linder, S P; Zeidler, J R

2004-01-01T23:59:59.000Z

474

EPA's Target Finder calculator | ENERGY STAR  

NLE Websites -- All DOE Office Websites (Extended Search)

sample in the nation, plus have it normalized for size, operating characteristics, and weather. Target Finder Access ENERGY STAR Target Finder When to use Portfolio Manager instead...

475

Energy Efficiency Targets | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Targets Energy Efficiency Targets Eligibility Utility Program Information Maine Program Type Energy Efficiency Resource Standard In June 2009, Maine enacted the ''Act Regarding...

476

Method for producing laser targets  

DOE Patents (OSTI)

An apparatus and method for producing deuterium targets or pellets of 25.mu. to 75.mu. diameter. The pellets are sliced from a continuously spun solid deuterium thread at a rate of up to 10 pellets/second. The pellets after being sliced from the continuous thread of deuterium are collimated and directed to a point of use, such as a laser activated combustion or explosion chamber wherein the pellets are imploded by laser energy or laser produced target plasmas for neutral beam injection.

Jarboe, Thomas R. (Oakland, CA); Baker, William R. (Orinda, CA)

1977-01-01T23:59:59.000Z

477

Foam shell cryogenic ICF target  

SciTech Connect

A uniform cryogenic layer of DT fuel is maintained in a fusion target having a low density, small pore size, low Z rigid foam shell saturated with liquid DT fuel. Capillary action prevents gravitational slumping of the fuel layer. The saturated shell may be cooled to produce a solid fuel layer.

Darling, Dale H. (Pleasanton, CA)

1987-01-01T23:59:59.000Z

478

NIST Forensics Science -- Drugs and Toxicology  

Science Conference Proceedings (OSTI)

... Sign up to receive news about NIST Forensic Science. *Email Address. ... NIST Forensic Science — Drugs and Toxicology. Credit: iStock. ...

2013-09-23T23:59:59.000Z

479

FY 2012 Highlighted Sustainable Targets and Initiatives  

Energy.gov (U.S. Department of Energy (DOE))

Joint Environmental Management System (EMS) GoalsFY 2012 Highlighted Sustainable Targets and Initiatives

480

Efficient search algorithms for RNAi target detection  

Science Conference Proceedings (OSTI)

RNA interference (RNAi) is a posttranscriptional gene silencing mechanism used to study gene functions, inhibit viral activities, and treat diseases therapeutically. However, RNAi has off-target effects--non-target genes can be unintentionally silenced. ... Keywords: Off-target, RNAi target detection, Reverse string search, String inexact matching, String kernels, siRNA seed region

Shibin Qiu; Terran Lane; Cundong Yang

2007-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "targeted drug delivery" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Multishell inertial confinement fusion target  

DOE Patents (OSTI)

A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reactions accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

1987-01-01T23:59:59.000Z

482

Multishell inertial confinement fusion target  

DOE Patents (OSTI)

A method of fabricating multishell fuel targets for inertial confinement fusion usage. Sacrificial hemispherical molds encapsulate a concentric fuel pellet which is positioned by fiber nets stretched tautly across each hemispherical mold section. The fiber ends of the net protrude outwardly beyond the mold surfaces. The joint between the sacrificial hemispheres is smoothed. A ceramic or glass cover is then deposited about the finished mold surfaces to produce an inner spherical surface having continuously smooth surface configuration. The sacrificial mold is removed by gaseous reaction accomplished through the porous ceramic cover prior to enclosing of the outer sphere by addition of an outer coating. The multishell target comprises the inner fuel pellet concentrically arranged within a surrounding coated cover or shell by fiber nets imbedded within the cover material.

Holland, James R. (Butler, PA); Del Vecchio, Robert M. (Vandergrift, PA)

1984-01-01T23:59:59.000Z

483

Target preparations and thickness measurements  

SciTech Connect

A wide variety of isotope target preparative methods have been used, including rolling of metals, vapor deposition, electrodeposition, chemical vapor deposition, and sputtering, to obtain thin and thick films of most elements or compounds of elements in the Periodic Table. Most thin films prepared for use in self-supported form as well as those deposited on substrates require thickness measurement (atom count and distribution) and/or thickness uniformity determination before being used in nuclear research. Preparative methods are described together with thickness and uniformity determination procedures applicable to samples being prepared (in situ) and to completed samples. Only nondestructive methods are considered applicable to target samples prepared by the ORNL Solid State Division, Isotope Research Materials Laboratory. Thickness or areal density measurements of sufficient sophistication to yield errors of less than +-1 percent have been achieved with regularity. A statistical analysis procedure is applied which avoids error caused by balance zero-point drift in direct weight measurement methods. (auth)

Adair, H.L.; Kobisk, E.H.

1975-01-01T23:59:59.000Z

484

Office of Electricity Delivery and Energy Reliability, OE-20  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

January, 2012 January, 2012 Office of Electricity Delivery and Energy Reliability, OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 Greetings: The Wyoming Infrastructure Authority (WIA) hereby submits its initial comments on the 2012 National Electric Transmission Congestion Study (the 2012 Study). The WIA is an instrumentality of the State of Wyoming, created in 2004 by the Wyoming State Legislature and is tasked with "diversifying and expanding the Wyoming economy through improvements in the state's electric transmission infrastructure and to facilitate the consumption of Wyoming energy by planning, financing, constructing, developing, acquiring, maintaining and operating electric transmission facilities, advanced coal technology facilities, advanced energy technology facilities

485

Mr. Lamont Jackson Office of Electricity Delivery and Energy Reliability  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

8, 2012 8, 2012 Mr. Lamont Jackson Office of Electricity Delivery and Energy Reliability Mail Code: OE-20 U.S. Department of Energy 1000 Independence Avenue SW Washington, DC 20585 Submitted via email to: Lamont.Jackson@hq.doe.gov Re: Department of Energy - Rapid Response Team for Transmission Request for Information, RRTT-IR-01, 77 Fed. Reg. 11517 (Feb. 27, 2012) Dear Mr. Jackson: Southern California Edison Company submits these comments in response to the Department of Energy's Request for Information concerning the efforts to resolve the issue of "incongruent development timelines" for the siting and permitting of electricity

486

THE HANFORD WASTE FEED DELIVERY OPERATIONS RESEARCH MODEL  

SciTech Connect

Washington River Protection Solutions (WRPS), the Hanford tank farm contractor, is tasked with the long term planning of the cleanup mission. Cleanup plans do not explicitly reflect the mission effects associated with tank farm operating equipment failures. EnergySolutions, a subcontractor to WRPS has developed, in conjunction with WRPS tank farms staff, an Operations Research (OR) model to assess and identify areas to improve the performance of the Waste Feed Delivery Systems. This paper provides an example of how OR modeling can be used to help identify and mitigate operational risks at the Hanford tank farms.

BERRY J; GALLAHER BN

2011-01-13T23:59:59.000Z

487

Mar. Drugs 2013, 11, 3350-3371; doi:10.3390/md11093350 marine drugs  

E-Print Network (OSTI)

Mar. Drugs 2013, 11, 3350-3371; doi:10.3390/md11093350 marine drugs ISSN 1660-3397 www% cytotoxicity was observed at the highest concentration tested (5 µg mL-1 ). However, OPEN ACCESS #12;Mar. Drugs Pinna had first been implicated in food poisoning in China in 1990 [1]. Pinnatoxin A (Pn

Recanati, Catherine

488

Coherent Communications, Imaging and Targeting  

SciTech Connect

Laboratory and field demonstration results obtained as part of the DARPA-sponsored Coherent Communications, Imaging and Targeting (CCIT) program are reviewed. The CCIT concept uses a Phase Conjugation Engine based on a quadrature receiver array, a hologram processor and a spatial light modulator (SLM) for high-speed, digital beam control. Progress on the enabling MEMS SLM, being developed by a consortium consisting of LLNL, academic institutions and small businesses, is presented.

Stappaerts, E; Baker, K; Gavel, D; Wilks, S; Olivier, S; Brase, J; Olivier, S; Brase, J

2003-10-03T23:59:59.000Z

489

DOE Hydrogen and Fuel Cells Program: 2005 Annual Progress Report - Delivery  

NLE Websites -- All DOE Office Websites (Extended Search)

Delivery Delivery Printable Version 2005 Annual Progress Report V. Delivery This section of the 2005 Progress Report for the DOE Hydrogen Program focuses on delivery. Each technical report is available as an individual Adobe Acrobat PDF. Download Adobe Reader. Hydrogen Delivery Sub-program Overview, Mark Paster, Department of Energy (PDF 159 KB) A. Pipelines Hydrogen Permeability and Integrity of Hydrogen Transfer Pipelines, Zhili Feng, Oak Ridge National Laboratory (PDF 596 KB) New Materials for Hydrogen Pipelines, Barton Smith, Oak Ridge National Laboratory (PDF 562 KB) Materials Solutions for Hydrogen Delivery in Pipelines, Subodh K. Das, SECAT Inc (PDF 248 KB) Evaluation of Natural Gas Pipeline Materials for Hydrogen/Mixed Hydrogen-natural Gas Service, Thad M. Adams, Savannah River National

490

Chemical Innovation in Drug Dr Matthew Fuchter  

E-Print Network (OSTI)

Chemical Innovation in Drug Discovery Dr Matthew Fuchter Lecturer in Synthetic and Medicinal&D Spending and Output #12;Chemical Innovation Impact Discovery Development Basic research: years 0-3 Pre 3, File DRUG Chemical start point Hit to lead Preclinical Assessment Synthetic Chemistry Chemistry

491

source_target+_rev11.PDF  

NLE Websites -- All DOE Office Websites (Extended Search)

4-1 - April 15 4-1 - April 15 th , 2000 4. Target System and Support Facility 4.1 Overview The target facility extends from the pre-target primary beam focusing to the end of the decay channel. Technical components include the target, beam absorber, and solenoid magnetic field focusing system. While the ultimate goal is to target approximately 4 MW of proton beam in the target area, smaller values and different target materials (low Z etc.) are considered for the first phase of operation. Chosen initially is a carbon target with incident primary beam power of 1.5 MW. The target is embedded in a high field solenoid magnet of 20 Tesla, and followed by a matching section channel, where the field tapers down to 1.25 T. An iterative design process has been carried out in optimizing Monte

492

LIFE Target Fabrication Research Plan Sept 2008  

SciTech Connect

The target-system for the baseline LIFE fast-ignition target was analyzed to establish a preliminary estimate for the costs and complexities involved in demonstrating the technologies needed to build a prototype LIFE plant. The baseline fast-ignition target upon which this analysis was developed is shown in Figure 1.0-1 below. The LIFE target-system incorporates requirements for low-cost, high throughput manufacture, high-speed, high accuracy injection of the target into the chamber, production of sufficient energy from implosion and recovery and recycle of the imploded target material residue. None of these functions has been demonstrated to date. Existing target fabrication techniques which lead to current 'hot spot' target costs of {approx}$100,000 per target and at a production rate of 2/day are unacceptable for the LIFE program. Fabrication techniques normally used for low-cost, low accuracy consumer products such as toys must be adapted to the high-accuracy LIFE target. This will be challenge. A research program resulting is the demonstration of the target-cycle technologies needed for a prototype LIFE reactor is expected to cost {approx}$51M over the course of 5 years. The effort will result in targets which will cost an estimated $0.23/target at a rep-rate of 20 Hz or about 1.73M targets/day.

Miles, R; Biener, J; Kucheyev, S; Montesanti, R; Satcher, J; Spadaccini, C; Rose, K; Wang, M; Hamza, A; Alexander, N; Brown, L; Hund, J; Petzoldt, R; Sweet, W; Goodin, D

2008-11-10T23:59:59.000Z

493

Spatiotemporal controlled delivery of nanoparticles to injured vasculature  

E-Print Network (OSTI)

Complex multimodal nanoparticles (NP) that target and deliver therapeutic agents to a site of disease are a promising direction in modem medicine. As a starting point for innovation, we designed a hybrid NP system combining ...

Chan, Juliana Maria

2010-01-01T23:59:59.000Z

494

Spatiotemporal controlled delivery of nanoparticles to injured vasculature  

E-Print Network (OSTI)

There are a number of challenges associated with designing nanoparticles for medical applications. We define two challenges here: (i) conventional targeting against up-regulated cell surface antigens is limited by heterogeneity ...

Chan, Juliana Maria

495

DOE Hydrogen and Fuel Cells Program Record 12022: Hydrogen Delivery...  

NLE Websites -- All DOE Office Websites (Extended Search)

Date: July 12, 2013 Item: Reported below are past 2005 and 2011 estimates, and target costs of delivering and dispensing (untaxed) H 2 to 10%-15% of the vehicles within a city...

496

FedEx Gasoline Hybrid Electric Delivery Truck Evaluation: 6-Month...  

NLE Websites -- All DOE Office Websites (Extended Search)

7693 May 2010 FedEx Gasoline Hybrid Electric Delivery Truck Evaluation: 6-Month Interim Report R. Barnitt National Renewable Energy Laboratory 1617 Cole Boulevard, Golden, Colorado...

497

FY 2014 Budget Request for the Office of Electricity Delivery and Energy Reliability  

Energy.gov (U.S. Department of Energy (DOE))

Table showing the FY 2012 Current Appropriation, the FY 2013 Annualized Continuing Resolution, and the FY 2014 Congressional Request for the Office of Electricity Delivery and Energy Reliability.

498

2011 Annual Planning Summary for Electricity Delivery and Energy Reliability (OE)  

Energy.gov (U.S. Department of Energy (DOE))

The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2011 and 2012 within the Office of Electricity Delivery and Energy Reliability (OE).

499

Novel carbon dioxide tolerant ceramic membrane for air separation and clean energy delivery.  

E-Print Network (OSTI)

??The ceramic membrane is drawing ever-increasing attention due to its potential in oxygen production and clean energy delivery. However, there are still many challenges which… (more)

Zhang, Kun

2013-01-01T23:59:59.000Z

500

,"Share of Total U.S. Natural Gas Electric Power Deliveries ...  

U.S. Energy Information Administration (EIA) Indexed Site

Electric Power Deliveries " ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Share of Total...