National Library of Energy BETA

Sample records for retinitis pigmentosa rp

  1. Molecular analysis and genetic mapping of the rhodopsin gene in families with autosomal dominant retinitis pigmentosa

    SciTech Connect (OSTI)

    Bunge, S.; Wedemann, H.; Samanns, C.; Horn, M.; Schwinger, E.; Gal, A. (Medizinische Universitaet zu Luebeck (Germany)); David, D. (Laboratorio de Genetica Humana, Lisbon (Portugal)); Terwilliger, D.J.; Ott, J. (Columbia Univ., New York, NY (United States)); Born, L.I. van den (The Netherlands Ophthalmic Research Institute, Amsterdam (Netherlands)) (and others)

    1993-07-01

    Eighty-eight patients/families with autosomal dominant retinitis pigmentosa (RP) were screened for rhodopsin mutations. Direct sequencing revealed 13 different mutations in a total of 14 (i.e., 16%) unrelated patients. Five of these mutations (T4K, Q28H, R135G, F220C, and C222R) have not been reported so far. In addition, multipoint linkage analysis was performed on two large families with autosomal dominant RP due to rhodopsin mutations by using five DNA probes from 3q21-q24. No tight linkage was found between the rhodopsin locus (RHO) and D3S47 ([theta][sub max] = 0.08). By six-point analysis, RHO was localized in the region between D3S21 and D3S47, with a maximum lod score of 13.447 directly at D3S20. 13 refs., 1 fig., 2 tabs.

  2. Localizing multiple X chromosome-linked retinitis pigmentosa loci using multilocus homogeneity tests

    SciTech Connect (OSTI)

    Ott, J.; Terwilliger, J.D. (New York State Psychiatric Institute, New York (USA)); Bhattacharya, S. (Univ. of Newcastle upon Tyne (England)); Chen, J.D.; Denton, J.; Donald, J. (Prince of Wales Hospital, Randwick (Australia)); Dubay, C.; Litt, M.; Weleber, R.G. (Oregon Health Sciences Univ., Portland (USA)); Farrar, G.J.; Humphries, P. (Trinity College, Dublin (Ireland)); Fishman, G.A.; Wong, F. (Univ. of Illinois, Chicago (USA)); Frey, D.; Maechler, M. (Institute of Medical Genetics, Zurich (Switzerland))

    1990-01-01

    Multilocus linkage analysis of 62 family pedigrees with X chromosome-linked retinitis pigmentosa (XLRP) was undertaken to determine the presence of possible multiple disease loci and to reliability estimate their map location. Multilocus homogeneity tests furnish convincing evidence for the presence of two XLRP loci, the likelihood ratio being 6.4 {times} 10{sup 9}:1 in a favor of two versus a single XLRP locus and gave accurate estimates for their map location. In 60-75% of the families, location of an XLRP gene was estimated at 1 centimorgan distal to OTC, and in 25-40% of the families, an XLRP locus was located halfway between DXS14 (p58-1) and DXZ1 (Xcen), with an estimated recombination fraction of 25% between the two XLRP loci. There is also good evidence for third XLRP locus, midway between DXS28 (C7) and DXS164 (pERT87), supported by a likelihood ratio of 293:1 for three versus two XLRP loci.

  3. Retinitis Pigmentosa and Hannah Arnson

    E-Print Network [OSTI]

    Wang, Yan Mei

    LR, Bloom FE, et al. Fundamental Neuroscience. 2nd edition. 2003 Hartong DT, Berson EL, Dryja TP-188 203-207 211 Computational research regarding 164 studied residues: 91/164 (55%) don't affect folding

  4. Organization and differentiation of stem cells on delivery scaffold for retinal tissue engineering

    E-Print Network [OSTI]

    Ko, Chi Wan

    2011-01-01

    Retinal degenerative diseases, including retinitis pigmentosa and age-related macular degeneration, affect more than ten million people in the US. Currently, there is no proven visually beneficial treatment for these types ...

  5. 4065 (RP-664) Heat Transfer

    E-Print Network [OSTI]

    of roomsurface-to-air heat transmission is dependentonan accurateestimateof the filmcoefficient. Forty- eight4065 (RP-664) Convective Energy and Heat Transfer Thermal Load in Building Calculations Daniel E convection film coefficients significantly underpredict the rate of surface convective heat 'transfer

  6. Visual Prostheses: Current Progress and Challenges Luke Theogarajan1

    E-Print Network [OSTI]

    Kelly, Shawn K.

    of exquisite neural circuitry that performs an amazing level of processing. Hence, the greatest chance of building a successful retinal prosthesis is to start with diseases that leave much of the retinal, the photoreceptor layer, of the retina. The first is AMD and the second is retinitis pigmentosa (RP), both

  7. RP-5 RENEWABLE ENERGY PROJECT

    SciTech Connect (OSTI)

    Neil Clifton; Eliza Jane Whitman; Jamal A. Zughbi

    2003-01-30

    This is the second quarterly technical report for the RP-5 Renewable Energy Project. The report summarizes the work progress, effort and activities that took place during the period of October 1, 2002 to December 31, 2002. The report has been prepared in accordance with the Department of Energy (DOE) Guidelines. This technical report covers all meetings and discussions that were conducted in order to follow up on potential renewable energy technologies that were identified in the previous report; the technologies were analyzed for their feasibility, suitability and cost effectiveness for this project. This report covers the one-day conceptual design kickoff meeting that took place on November 4, 2002. The meeting was held to discuss the practicality and implementation of potential innovative technologies. Following the kickoff meeting, Inland Empire Utilities Agency (IEUA) and CH2M Hill, the Public Interest Energy Research (PIER) Consultant, held a meeting on December 2, 2002 to discuss the Conceptual Design Report outline and contents in order to clearly present each selected technology along with its evaluation, cost effectiveness and justification. A conference call also took place between the PIER Consultant and IEUA on December 13, 2002, to discuss the overall scope of work for this project. Major project activities in this period include expanded discussions on previous Energy Charrette decisions and recommendations, conceptual design kickoff meeting, conceptual design report, and deciding on the overall project scope of work.

  8. Deforming convex RP3-structures on 3-orbifolds Deforming convex RP3-structures on 3-orbifolds

    E-Print Network [OSTI]

    Choi, Suhyoung

    Deforming convex RP3-structures on 3-orbifolds Deforming convex RP3-structures on 3-orbifolds-structures on 3-orbifolds Introduction Orbifolds and RPn-structures Orbifolds By an n-dimensional orbifold . an inclusion Uj Ui induces an equivariant map ~Uj ~Ui with respect to Gj Gi . A RPn-structure on an orbifold

  9. Deforming convex RP3-structures on 3-orbifolds Deforming convex RP3-structures on 3-orbifolds

    E-Print Network [OSTI]

    Choi, Suhyoung

    Deforming convex RP3-structures on 3-orbifolds Deforming convex RP3-structures on 3-orbifolds-structures on 3-orbifolds Outline A RPn-structure (projectively flat structure; real projective structure; projective structure) on an orbifold is a geometric structure on the orbifold modelled on (RPn, PGL(n + 1, R

  10. Nucleosynthesis and the rp-process

    SciTech Connect (OSTI)

    Nabi, Jameel-Un [Faculty of Engineering Sciences, GIK Institute of Engineering Sciences and Technology, Topi 23640, Swabi, Khyber Pakhtunkhwa (Pakistan)

    2012-11-20

    Production of elements heavier than iron, their abundance and cite of production remain an active field of research to-date. In this paper I would present a brief review of the nucleosynthesis process and then focus further on the proton capture processes with particular emphasis on the nuclear physics aspects of the rp-process. The present calculation clearly shows that the electron capture rates on waiting point nuclei are at least of similar magnitude as the competing positron decay rates under rp-process conditions. The study strongly suggests that electron capture rates form an integral part of weak-interaction mediated rates under rp-process conditions and should not be neglected in nuclear reaction network calculations as done in past.

  11. RP-5 Renewable Energy Efficiency Project

    SciTech Connect (OSTI)

    Neil Clifton; Dave Wall; Jamal Zughbi

    2007-06-30

    This is the final technical report for the RP-5 Renewable Energy Efficiency Project (REEP). The report summarizes, in a comprehensive manner, all the work performed during the award period extending between July 12, 2002 and June 30, 2007. This report has been prepared in accordance with the Department of Energy (DOE) Guidelines and summarizes all of the activities that occurred during the award period. The RP-5 Renewable Energy Efficiency Project, under development by the Inland Empire Utilities Agency (IEUA), is comprised of a series of full-scale demonstration projects that will showcase innovative combinations of primary and secondary generation systems using methane gas derived from local processing of biosolids, dairy manure and other organic material. The goal of the project is to create renewable energy-based generation systems with energy efficiencies 65% or more. The project was constructed at the 15 MGD Regional Wastewater Treatment Plant No. 5 located in the City of Chino in California where the Agency has constructed its new energy-efficient (platinum-LEED rating) headquarters building. Technologies that were featured in the project include internal combustion engines (ICE), absorption chillers, treatment plant secondary effluent cooling systems, heat recovery systems, thermal energy storage (TES), Organic Rankine Cycle (ORC) secondary power generation system, the integration of a future fuel cell system, gas cleaning requirements, and other state-of-the-art design combinations. The RP-5 REEP biogas source is coming from three manure digesters which are located within the RP-5 Complex and are joined with the RP-5 REEP through gas conveyance pipelines. Food waste is being injected into the manure digesters for digester gas production enhancement. The RP-5 REEP clearly demonstrates the biogas production and power generation viability, specifically when dealing with renewable and variable heating value (Btu) fuel. The RP-5 REEP was challenged with meeting stringent utility, gas, power, and air quality rules and regulations. Coordination with the Southern California Gas Company (SCGC), Southern California Edison (SCE), and South Coast Air Quality Management District (SCAQMD) was continuous and extensive. The interconnecting agreement and the permit to construct and operate were major obstacles despite the early start and coordination with the utility companies and regulatory agencies. The RP-5 REEP is part of a unique RP-5 Complex approach where several facilities are tied and connected with each other; where energy and gas can be transferred from one facility to another (see attached RP-5 Complex Ultimate Energy Balance Diagram). The REEP also incorporated new technologies, such as TES and ORC, along with using heat recovery for the platinum-LEED headquarter buildings heating and cooling via efficient absorption chillers. Through the conceptual design phase, numerous innovative technologies were researched and evaluated, with the most proven and efficient selected to be part of the RP-5 REEP.

  12. enter part number BNC / RP-BNC

    E-Print Network [OSTI]

    Berns, Hans-Gerd

    enter part number Products 7/16 1.0/2.3 1.6/5.6 AFI AMC BNC / RP-BNC C FAKRA SMB FME HN MCX Mini ------- Product Search ------- Inventory Search Search Results for: 31-10152-RFX Results: 1 - 1 of 1 Part Number. All rights reserved. Copyright | Terms & Conditions | RF E-Mail Client | Contact Us | Amphenol

  13. Retinal Neurotransmitters Robert E. Marc

    E-Print Network [OSTI]

    Marc, Robert E.

    Retinal Neurotransmitters Robert E. Marc John Moran Eye Center University of Utah School of References: 85 Abbreviated Title: Retinal Neurotransmitters *Correspondence to: Robert E. Marc, Moran Eye-6500. Facsimile (801) 581-3357 robert.marc@hsc.utah.edu #12;Rbert E. Marc Retinal Neurotransmitters Introduction

  14. RP-5 Renewable Energy Efficiency Project

    SciTech Connect (OSTI)

    Neil Clifton; Eliza Jane Whitman; Jamal A. Zughbi

    2003-07-28

    This is the fourth quarterly technical report for the RP-5 Renewable Energy Efficiency Project. The report summarizes the work progress, effort and activities that took place during the period of April 1, 2003 to June 30, 2003. However, IEUA is preparing a Supplemental report that will be mailed to the Department of Energy (DOE) by August 1, 2003, that provides additional information regarding IEUA's plan to expedite certain project activities. The report has been prepared in accordance with the Department of Energy (DOE) Guidelines. This technical report covers all meetings, discussions, and engineering and design activities that took place to finalize the project scope of work and complete the Request for Proposal (RFP) for the RP-5 Renewable Energy Efficiency Project. IEUA has decided to invite three more consulting engineering firms besides CH2M Hill, the Public Interest Energy Research (PIER) Consultant, to submit proposals for the design of the energy efficiency project. The proposals are currently in the evaluation phase and a decision is expected by the end of July. IEUA moved to its new headquarters building on June 13, 2003. The central plant is the system that supplies cooling and heating water to the headquarters building, and it primarily consists of equipment listed in the cooperative agreement under ''Chiller and Heater''. The central plant equipment was successfully installed and started. Other activities include gas analysis of three sources of low quality digester gas and foul air which could be used as fuel for an innovative flex microturbine. IEUA is also working with Stirling Energy Systems to determine if the Agency should be a host site for their equipment for testing the engine's operation on digester and natural gas. A matching funds update is also included in the Results and Discussion section, which presents the work effort performed by the PIER Consultant and the associated costs that serve as matching funds for the RP-5 Project during this report period.

  15. Cellular Mechanisms Underlying Retinal Wave Generation

    E-Print Network [OSTI]

    Ford, Kevin

    2011-01-01

    Underlying Retinal Wave Generation By Kevin J Ford AUnderlying Retinal Wave Generation By Kevin J Ford Doctor ofwith age, so does the wave generation mechanism. The most

  16. RP-5 Renewable Energy Efficiency Project

    SciTech Connect (OSTI)

    Neil Clifton; Eliza Jane Whitman; Jamal A. Zughbi

    2004-01-29

    This is the sixth quarterly technical report for the RP-5 Renewable Energy Efficiency Project. The report summarizes the work progress, effort and activities that took place during the period from October 1, 2003 through December 31, 2003. The report has been prepared in accordance with the Department of Energy (DOE) Guidelines. In coordination with the DOE, IEUA has revised the original Cooperative Agreement to reflect the actual and current project scope of work. The original Agreement statement of work (SOW) included conceptual and preliminary equipment and systems, which were further evaluated for feasibility and suitability for the project. As a result, some of the equipment was taken out of the project scope. In response to questions from the DOE, IEUA has submitted a summary report on the Organic Rankine Cycle (ORC) secondary power generation units for availability and suitability for this project and associated safety concerns pointed out by the DOE. IEUA has awarded the consulting engineering contract to Parsons Water and Infrastructure, Inc. to provide the project's design and construction services. The project's pre-design kickoff meeting was held at IEUA's headquarters on December 11, 2003. IEUA has submitted a proposal for a grant offered by California Energy Commission (CEC) which if awarded to IEUA, will add value to this project. IEUA has finalized and signed the agreement with Stirling Energy Systems (SES) to host a 25 kW Stirling Engine at the RP-5 plant site for reliability and performance testing using digester and natural gas. As a result of further evaluation of the flexible microturbine system, IEUA has decided to take it out of the project's scope of work; however, it may be considered in future projects at other locations. IEUA has installed a 60 kW Photovoltaic (PV) power generation system on the roof of the new headquarters building. A matching funds update is also included in the Results and Discussion section. The update presents the work effort performed by CH2M Hill, the PIER Consultant, and the associated costs that serve as matching funds for the RP-5 Renewable Energy Efficiency Project during this report period.

  17. A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors

    SciTech Connect (OSTI)

    Zhou, Dan, E-mail: DZhou@syntapharma.com [Synta Pharmaceuticals Corp., 45 Hartwell Avenue, Lexington, MA 02421 (United States); Liu, Yuan; Ye, Josephine; Ying, Weiwen; Ogawa, Luisa Shin; Inoue, Takayo; Tatsuta, Noriaki; Wada, Yumiko; Koya, Keizo [Synta Pharmaceuticals Corp., 45 Hartwell Avenue, Lexington, MA 02421 (United States); Huang, Qin [Department of Pathology and Laboratory Medicine, Veterans Affairs Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA 02132 (United States); Bates, Richard C.; Sonderfan, Andrew J. [Synta Pharmaceuticals Corp., 45 Hartwell Avenue, Lexington, MA 02421 (United States)

    2013-12-01

    In human trials certain heat shock protein 90 (Hsp90) inhibitors, including 17-DMAG and NVP-AUY922, have caused visual disorders indicative of retinal dysfunction; others such as 17-AAG and ganetespib have not. To understand these safety profile differences we evaluated histopathological changes and exposure profiles of four Hsp90 inhibitors, with or without clinical reports of adverse ocular effects, using a rat retinal model. Retinal morphology, Hsp70 expression (a surrogate marker of Hsp90 inhibition), apoptotic induction and pharmacokinetic drug exposure analysis were examined in rats treated with the ansamycins 17-DMAG and 17-AAG, or with the second-generation compounds NVP-AUY922 and ganetespib. Both 17-DMAG and NVP-AUY922 induced strong yet restricted retinal Hsp70 up-regulation and promoted marked photoreceptor cell death 24 h after the final dose. In contrast, neither 17-AAG nor ganetespib elicited photoreceptor injury. When the relationship between drug distribution and photoreceptor degeneration was examined, 17-DMAG and NVP-AUY922 showed substantial retinal accumulation, with high retina/plasma (R/P) ratios and slow elimination rates, such that 51% of 17-DMAG and 65% of NVP-AUY922 present at 30 min post-injection were retained in the retina 6 h post-dose. For 17-AAG and ganetespib, retinal elimination was rapid (90% and 70% of drugs eliminated from the retina at 6 h, respectively) which correlated with lower R/P ratios. These findings indicate that prolonged inhibition of Hsp90 activity in the eye results in photoreceptor cell death. Moreover, the results suggest that the retina/plasma exposure ratio and retinal elimination rate profiles of Hsp90 inhibitors, irrespective of their chemical class, may predict for ocular toxicity potential. - Highlights: • In human trials some Hsp90 inhibitors cause visual disorders, others do not. • Prolonged inhibition of Hsp90 in the rat eye results in photoreceptor cell death. • Retina/plasma ratio and retinal elimination rate are linked to toxicity potential. • Rat retinotoxic responses to individual Hsp90 inhibitors reflect clinical profiles. • Rodent modeling may be used to assess ocular risks of targeted Hsp90 compounds.

  18. Science and Technology Roadmap Cooperative Research Program (CoRP)

    E-Print Network [OSTI]

    Kuligowski, Bob

    Science and Technology Roadmap Cooperative Research Program (CoRP) National Oceanic and Atmospheric.3.2 The Global Precipitation Climatology Project 5. SCIENCE AND TECHNOLOGY ROADMAP 6. PERFORMANCE TARGETS 6RP research capabilities are described along with a science roadmap for the next decade. This science

  19. Neuronal Circuitry of the Local Edge Detector Retinal Ganglion Cell

    E-Print Network [OSTI]

    Russell, Thomas Lee

    2010-01-01

    but their role in retinal signal processing has not beenF. S. (2006). Parallel processing in retinal ganglion cells:

  20. Retinal Remodeling Triggered by Photoreceptor Degenerations

    E-Print Network [OSTI]

    Marc, Robert E.

    retina drive signal-processing circuitries of the neural retina. Most retinal degenerationsRetinal Remodeling Triggered by Photoreceptor Degenerations BRYAN W. JONES,1* CARL B. WATT,1 JEANNE retina is largely resistant to this sensory deafferentation. New evidence from fast retinal degenerations

  1. Cellular Mechanisms Underlying Retinal Wave Generation

    E-Print Network [OSTI]

    Ford, Kevin

    2011-01-01

    assembled by short-range cellular interactions. J Neurosci,II. III. Cellular mechanisms underlying cholinergic retinalL. Felix, Marla B. Feller. Cellular Mechanisms underlying

  2. Alpha Emission Near 100Sn and the Termination of the rp Process

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alpha Emission Near 100 Sn and the Termination of the rp Process The astrophysical rp-process is thought to reach a termination point in the region of 100 Sn, via the...

  3. Photovoltaic retinal prosthesis with high pixel density

    E-Print Network [OSTI]

    Palanker, Daniel

    Photovoltaic retinal prosthesis with high pixel density Keith Mathieson1,4 , James Loudin1 to stimulating electrodes via intraocular cables. We present a photovoltaic subretinal prosthesis, in which pixel, demonstrating the possibility of a fully integrated photovoltaic retinal prosthesis with high

  4. Acceleration of the Retinal Vascular Tracing Algorithm

    E-Print Network [OSTI]

    Kepner, Jeremy

    Acceleration of the Retinal Vascular Tracing Algorithm using FPGAs Direction Filter Design FPGA along with image processing results at frame rate with low latency Results MEMORY 2 Results MEMORY 3 Memory Switching Design #12;Retinal Vascular Tracing Application Goal: Detection and enhancement

  5. Molecular Evolution of Adeno-associated Virus for Improved Retinal Gene Therapies

    E-Print Network [OSTI]

    Klimczak, Ryan Raymond

    2010-01-01

    the complexity of retinal processing and visual informationcortical processing (Figure 1.1). The retinal pigmentto visual processing [71]. Also, in most retinal diseases,

  6. RP Global Spain S A Minicentrales | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop Inc Jump to:Newberg,Energy LLCALLETEREFU Elektronik GmbH JumpChinaRM Eolica JumpRP

  7. Integrated computational system for portable retinal imaging

    E-Print Network [OSTI]

    Boggess, Jason (Jason Robert)

    2012-01-01

    This thesis introduces a system to improve image quality obtained from a low-light CMOS camera-specifically designed to image the surface of the retina. The retinal tissue, as well as having various diseases of its own, ...

  8. Novel Measures Of Retinal Health And Their Inter- relationships In Early Diabetes

    E-Print Network [OSTI]

    Dhamdhere, Kavita P.

    2012-01-01

    and luminosity processing in retinal disease. Am J Optomand luminosity processing in retinal disease. Am J Optom

  9. Microsoft Word - 2015-03-17_FINALRev0_SRNL-RP-2014-01198c

    Office of Environmental Management (EM)

    SRNL-RP-2014-01198 Revision 0 March 17, 2015 Page 3 of 277 Keywords: Waste Isolation Pilot Plant, WIPP, transuranic, TRU, drum Retention: Permanent Waste...

  10. Fluid Dynamics in Sucker Rod Pumps Cutler, R.P.; Mansure, A.J...

    Office of Scientific and Technical Information (OSTI)

    Fluid Dynamics in Sucker Rod Pumps Cutler, R.P.; Mansure, A.J. 02 PETROLEUM; FLOW MODELS; MATHEMATICAL MODELS; OIL WELLS; PETROLEUM; ROD PUMPS; SANDIA NATIONAL LABORATORIES Sucker...

  11. Application of a new screening model to thermonuclear reactions of the rp process

    E-Print Network [OSTI]

    Theodore Liolios

    2003-05-09

    A new screening model for astrophysical thermonuclear reactions was derived recently which improved Salpeter's weak-screening one. In the present work we prove that the new model can also give very reliable screening enhancement factors (SEFs) when applied to the rp process. According to the results of the new model, which agree well with Mitler's SEFs, the screened rp reaction rates can be, at most, twice as fast as the unscreened ones.

  12. Patterned electrical stimulation of primate retina for the development of retinal prostheses

    E-Print Network [OSTI]

    Jepson, Lauren Hruby

    2012-01-01

    In addition, models of retinal processing typically onlyretinal interneurons (3), which perform initial processingthe processing normally provided by the retinal circuitry

  13. The population perspective : how primate retinal ganglion cells collectively encode visual space

    E-Print Network [OSTI]

    Gauthier, Jeffrey Lee

    2008-01-01

    energy e?ciency in retinal processing. Vision Res 43:1283–Although each layer of retinal processing has been studied

  14. PARALLEL PROCESSING: A RELATIONSHIP BETWEEN RETINAL AND FOURIER OPTICS TECHNIQUES

    E-Print Network [OSTI]

    Moore, John Barratt

    PARALLEL PROCESSING: A RELATIONSHIP BETWEEN RETINAL AND FOURIER OPTICS TECHNIQUES by D,J.H. Moore P #12;ABSTIbiCT Two methods of describing and processing visual data by replacing the pattern a retinal-machine approach. Modifications are suggested for the Fourier-optics approach which greatly

  15. Image Processing and Interface for Retinal Visual Wentai Liu1

    E-Print Network [OSTI]

    Arizona, University of

    Image Processing and Interface for Retinal Visual Prostheses Wentai Liu1 , Wolfgang Fink2 , Mark of pixels/electrodes of a retinal implant may restore low-resolution vision for unaided mobility and large print reading. We describe the real-time application of image processing techniques such as contrast

  16. Proposed changes to FED-STD-209 and IES-RP-CC006

    SciTech Connect (OSTI)

    Mielke, R.L.

    1992-12-31

    In the United States, two documents have been considered basic to work with cleanrooms and controlled environments. They are {ital Cleanroom and Work Station Requirements, Controlled Environment{emdash}Federal Standard 209D}, published by the U.S. General Services Administration, and {ital Recommended Practice for Testing Cleanrooms} (IES-RP-CC006), published by the Institute of Environmental Sciences (IES). FED-STD-209 is the authoritative document on air cleanliness classification and cleanroom certification. Recommended Practice 006 is the recognized source for testing cleanroom performance. This paper covers the purpose and proposed changes for both FED-STD-209D and IES-RP-CC006. 3 refs., 1 tab.

  17. $?$-Decay Half-Life of the $rp$-Process Waiting Point Nuclide $^{84}$Mo

    E-Print Network [OSTI]

    J. B. Stoker; P. F. Mantica; D. Bazin; A. Becerril; J. S. Berryman; H. L. Crawford; A. Estrade; C. J. Guess; G. W. Hitt; G. Lorusso; M. Matos; K. Minamisono; F. Montes; J. Pereira; G. Perdikakis; H. Schatz; K. Smith; R. G. T. Zegers

    2009-01-08

    A half-life of 2.2 $\\pm$ 0.2 s has been deduced for the ground-state $\\beta$ decay of $^{84}$Mo, more than 1$\\sigma$ shorter than the previously adopted value. $^{84}$Mo is an even-even N = Z nucleus lying on the proton dripline, created during explosive hydrogen burning in Type I X-ray bursts in the rapid proton capture ($rp$) process. The effect of the measured half-life on $rp$-process reaction flow is explored. Implications on theoretical treatments of nuclear deformation in $^{84}$Mo are also discussed.

  18. Numerical Simulations of the Island-Induced Circulations over the Island of Hawaii during HaRP

    E-Print Network [OSTI]

    Chen, Yi-Leng

    Numerical Simulations of the Island-Induced Circulations over the Island of Hawaii during HaRP YANG YANG AND YI-LENG CHEN Department of Meteorology, SOEST, University of Hawaii at Manoa, Honolulu, Hawaii island-scale circulations over the island of Hawaii during the Hawaiian Rainband Project (HaRP, 11 July

  19. Texas Transportation Institute, Agency 727 Energy Management and Conservation Plan (RP-49)

    E-Print Network [OSTI]

    consumption of electricity, motor fuels and natural gas. The Texas Transportation Institute (TTI) submittedTexas Transportation Institute, Agency 727 Energy Management and Conservation Plan (RP-49) Year implementations. This includes, but is not limited to, various electrical, gas, lighting and plumbing fixtures

  20. Convective heat transfer characteristics of China RP-3 aviation kerosene at supercritical pressure

    E-Print Network [OSTI]

    Guo, Zhixiong "James"

    Convective heat transfer characteristics of China RP-3 aviation kerosene at supercritical pressure Keywords: Supercritical pressure Aviation kerosene Convective heat transfer Numerical study a b s t r a c convective in kerosene pipe flow is complicated. Here the convective heat transfer characteristics of China

  1. Retinal Counterion Switch Mechanism in Vision Evaluated by Molecular Simulations

    E-Print Network [OSTI]

    181 exist as glutamates in the dark state and remain deprotonated through the MI state, giving a net circumstances. According to the original proposal,8 in the dark and bathorhodopsin states, the retinal PSB

  2. RSAC 6.2 with WinRP 2.0 User Manual

    SciTech Connect (OSTI)

    Bradley Schrader

    2005-09-01

    The Radiological Safety Analysis Computer Program (RSAC-6.2) calculates the consequences of a release of radionuclides to the atmosphere. Using a personal computer, a user can generate a fission product inventory from either reactor operating history or a nuclear criticality accident. RSAC-6.2 models the effects of high-efficiency particulate air filters or other cleanup systems and calculates decay and ingrowth during transport through processes, facilities, and the environment. Doses are calculated for resuspension, inhalation, immersion, ground surface, and ingestion pathways. WinRP 2.0, a windows based overlay to RSAC-6.2, assists users in creating and running RSAC-6.2 input files. This users manual contains the mathematical models and operating instructions for RSAC-6.2 and WinRP 2.0. Instructions, screens, and examples are provided to guide the user through the functions provided by RSAC-6.2 and WinRP 2.0. These programs are designed for users who are familiar with radiological dose assessment methods.

  3. Biomechanical Testing Of An Adhesive Polymer Intended For The Treatment Of Retinal Detachment

    E-Print Network [OSTI]

    Kerr, Mayuri

    2014-01-01

    of cyanoacrylate tissue adhesive in the rabbit. ,” Retina,and M. F. Marmor, “Retinal adhesive force in living rabbit,effects of retinal adhesive force in vivo. ,” Retina, vol.

  4. Probabilistic intra-retinal layer segmentation in 3-D OCT images using global shape regularization

    E-Print Network [OSTI]

    Schnörr, Christoph

    Probabilistic intra-retinal layer segmentation in 3-D OCT images using global shape regularization Processing (HCI), University of Heidelberg, Speyerer Str. 6, 69126 Heidelberg, Germany c Heidelberg 2014 Keywords: Statistical shape model Retinal layer segmentation Pathology detection Optical coherence

  5. Sparse representation and variational methods in retinal image J. Dobrosotskaya,1

    E-Print Network [OSTI]

    Ehler, Martin

    1 Sparse representation and variational methods in retinal image processing J. Dobrosotskaya,1 , M/LIMB/SMB, Bethesda, MD, 20892 Abstract - Relations between different types of cameras used for retinal imaging were analyt- ical models of the effects that cameras introduce into the retinal data and described possible

  6. Image Mining in IRIS: Integrated Retinal Information System Wynne Hsu, Mong Li Lee, Kheng Guan Goh

    E-Print Network [OSTI]

    Lee, Mong Li "Janice"

    , applies state-of- the-art data mining and image processing techniques on the retinal images to aid in the screening process. 2. Image Classification An abnormal retinal image has one or more of the following signs1 Image Mining in IRIS: Integrated Retinal Information System Wynne Hsu, Mong Li Lee, Kheng Guan

  7. Abstract Title: Image Informatics Tools for the Analysis of Retinal Images

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    Barbara, Santa Barbara, CA. Keywords: 682 retinal detachment, 541 image processing, 543 imagingAbstract Title: Image Informatics Tools for the Analysis of Retinal Images Presentation Start/End Time: Wednesday, May 03, 2006, 11:15 AM - 1:00 PM Location: Hall B/C Reviewing Code: 289 retinal

  8. An Updated Library of Reaction Rates for the Astrophysical rp-Process

    SciTech Connect (OSTI)

    Sakharuk, A.; Elliot, T.; Hemingray, S.; Smith, K. [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI 48824 (United States); Fisker, J. L.; Wiescher, M. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Kruizenga, A. [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI 48824 (United States); Rauscher, T.; Thielemann, F.-K. [Departement fuer Physik und Astronomie, Universitaet Basel, Klingelbergstrasse 82, CH-4056 Basel (Switzerland); Schatz, H. [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI 48824 (United States); Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824 (United States)

    2006-03-13

    We are developing an updated library with reaction rates important for the study of the astrophysical rp- process. It includes both experimental and theoretical rates parametrized in terms of the standard REACLIB format. The experimental data contain various compilations updated with the most recent data. The theoretical data are taken from shell-model calculations whenever available otherwise statistical Hauser-Feshbach calculations were used. All theoretical rates were recalculated using the latest reaction Q-values. All new rates include stellar enhancement factors. The data will be accessed through a convenient web interface. It is anticipated that this JINA project evolves into an evaluated public data archive for reaclib library data.

  9. Recent Advances in Retinal Imaging With Adaptive Optics

    E-Print Network [OSTI]

    Recent Advances in Retinal Imaging With Adaptive Optics 36 Optics & Photonics News January 2005-6938/05/01/0036/7-$0015.00 © Optical Society of America A daptive optics imaging systems use active optical elements to compensate for aberrations in the optical path between the camera and the object being imaged. In 1953, Babcock first

  10. Injury and Repair: Retinal Remodeling Robert E. Marc

    E-Print Network [OSTI]

    Marc, Robert E.

    Injury and Repair: Retinal Remodeling Robert E. Marc Department of Ophthalmology John A. Moran Eye Center 65 Mario Capecchi Dr University of Utah Salt Lake City, UT 84132 robert.marc@hsc.utah.edu Keywords photoreceptors In press Elsevier Encyclopedia of the Eye Robert E. Marc :: Chapter 220 :: Injury and Repair

  11. Effects of Methanol on the Retinal Function of Juvenile Rats

    E-Print Network [OSTI]

    Casanova, Christian

    Effects of Methanol on the Retinal Function of Juvenile Rats C. Plaziac1 , P. Lachapelle2 , C Received 18 April 2002; accepted 22 July 2002 Abstract We have investigated the effect of methanol exposure recorded prior to and up to 72 h after the administration of methanol. Data were compared to a control

  12. Variability of aerosol optical depth and aerosol forcing over India S. Sarkar, R. Chokngamwong, G. Cervone, R.P. Singh *, M. Kafatos

    E-Print Network [OSTI]

    Singh, Ramesh P.

    . Cervone, R.P. Singh *, M. Kafatos Centre for Earth Observing and Space Research, School of Computational is centrally located in the Indo-Gangetic basin. Recently, Singh et al. (2004) have discussed the annual-mail addresses: rsingh3@gmu.edu, rpalka425@gmail.com (R.P. Singh). www.elsevier.com/locate/asr Advances in Space

  13. FLATNESS EVALUATION FOR A V-FLASH RAPID PROTOTYPE (RP) MACHINE Abdon Godinez Velasco, Mohammed Anazi, Gaurav Ameta

    E-Print Network [OSTI]

    Collins, Gary S.

    of the object. There are two main types of RP: · Subtractive Manufacturing · Additive Manufacturing This research focuses on additive manufacturing (AM). V- Flash is a machine (see figure 1) that uses Engineering ,Washington State University, Pullman WA 99164 Abstract In today`s society manufacturing is very

  14. he application of rapid prototyping (RP) in fabricat-ing nonassembly robotic systems with inserts is pre-

    E-Print Network [OSTI]

    Mavroidis, Constantinos

    T he application of rapid prototyping (RP) in fabricat- ing nonassembly robotic systems with inserts is pre- sented in this article. The development of robotic systems that have all necessary of which are essential steps toward the future goal of automated (robotized) robot design and manufacturing

  15. UTS:LIBRARY AUG08/UTS:CRICOS CODE 00099F / RP080805 Filming at the UTS Library

    E-Print Network [OSTI]

    University of Technology, Sydney

    UTS:LIBRARY AUG08/UTS:CRICOS CODE 00099F / RP080805 Filming at the UTS Library: APPLICATION TO FILM WWW.LIB.UTS.EDU.AU UTS LIBRARY: FACILITIES Please send this completed form to: Director, Library Client Services Unit Level 3, Blake Library (City Campus) Corner Quay Street & Ultimo Road Haymarket, NSW

  16. Question of universality in RP{sup {ital n}{minus}1} and O({ital n}) lattice {sigma} models

    SciTech Connect (OSTI)

    Niedermayer, F.; Weisz, P.; Shin, D.

    1996-05-01

    We argue that there is no essential violation of universality in the continuum limit of mixed RP{sup {ital n}{minus}1} and O({ital n}) lattice {sigma} models in two dimensions, contrary to opposite claims in the literature. {copyright} {ital 1996 The American Physical Society.}

  17. Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on MRI 

    E-Print Network [OSTI]

    Doubal, F.N.; de Haan, R; MacGillivray, T.J.; Cohn-Hokke, P.; Dhillon, B.; Dennis, M.S.; Wardlaw, J.M.

    Background. Cerebral small vessel disease (lacunar stroke and cerebral white matter hyperintensities) is caused by vessel abnormalities of unknown aetiology. Retinal vessels show developmental and pathophysiological ...

  18. Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9-cis-Retinal Isomerase Activity

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9-cis-Retinal Isomerase Activity molecules in both CRALBP-assisted specificity toward 9-cis-retinal and its thermal isomerase activity opsin receptor molecules into photosensitive retinoid pigments of the eye. We report a thermal secondary

  19. An LDA-based relative hysteresis classifier with application to segmentation of retinal vessels

    E-Print Network [OSTI]

    Lübeck, Universität zu

    An LDA-based relative hysteresis classifier with application to segmentation of retinal vessels hysteresis methods and, for the problem of retina vessel segmentation, to known dedicated methods on similar, to support medical diagnosis and for intervention planning. To this end, the retinal vessels need

  20. Retinal Blood Vessels Segmentation Using the Radial Projection and Supervised Classification

    E-Print Network [OSTI]

    Cheung, Yiu-ming

    Retinal Blood Vessels Segmentation Using the Radial Projection and Supervised Classification Qinmu: ymc@comp.hkbu.edu.hk Abstract The low-contrast and narrow blood vessels in retinal images of improving detection of such vessels, we propose the ra- dial projection method to locate the vessel

  1. Retinal Vessel Extraction Using Multiscale Matched Filters, Confidence and Edge Measures

    E-Print Network [OSTI]

    Bystroff, Chris

    Retinal Vessel Extraction Using Multiscale Matched Filters, Confidence and Edge Measures Michal of improving detection of low-contrast and narrow vessels and eliminating false detections at non-vascular structures, a new technique is presented for extracting vessels in retinal images. The core of the technique

  2. Reaction Pathways of Photoexcited Retinal in Proteorhodopsin Studied by Pump-Dump-Probe Spectroscopy

    E-Print Network [OSTI]

    van Stokkum, Ivo

    Reaction Pathways of Photoexcited Retinal in Proteorhodopsin Studied by PumpR) is a membrane-embedded proton pump from the microbial rhodopsin family. Light absorption by its retinalR, using dispersed ultrafast pump-dump-probe spectroscopy. The application of a pump pulse initiates

  3. Improving retinal image resolution with iterative weighted shift-and-add

    E-Print Network [OSTI]

    Ribak, Erez

    1 Improving retinal image resolution with iterative weighted shift-and-add Nizan Meitav1 High-resolution retinal imaging requires dilating the pupil, and therefore exposing more aberrations that blur the image. We developed an image processing technique that takes advantage of the natu- ral

  4. MODELLING RETINAL FEATURE DETECTION WITH DEEP BELIEF NETWORKS IN A SIMULATED ENVIRONMENT

    E-Print Network [OSTI]

    Bargiela, Andrzej

    of retinal implant en- gineering, but could also improve image processing and computer vision algorithmsMODELLING RETINAL FEATURE DETECTION WITH DEEP BELIEF NETWORKS IN A SIMULATED ENVIRONMENT Diana and later stages of vi- sual processing found in the brain. Lower level processes such as those found

  5. Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary

    E-Print Network [OSTI]

    Tomasi, Carlo

    Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary.hendargo@duke.edu Abstract: Variance processing methods in Fourier domain optical coherence tomography (FD-OCT) have enabled demonstrate a method to eliminate motion artifacts in speckle variance FD-OCT images of the retinal

  6. On Chip Implementation of a Pixel-Parallel Approach for Retinal Vessel Tree Extraction

    E-Print Network [OSTI]

    Dudek, Piotr

    On Chip Implementation of a Pixel-Parallel Approach for Retinal Vessel Tree Extraction C. Alonso Univ. A Coru~na. SPAIN mgpenedo@udc.es Abstract-- Retinal vessel tree extraction from angiography applications. From the image processing point of view, many algorithms and strategies have been developed

  7. Modeling of the rhodopsin bleaching with variational analysis of retinal images J. Dobrosotskayaa

    E-Print Network [OSTI]

    Ehler, Martin

    processing were obtained via the cSLO camera (Heidelberg Retinal Angiograph 4.0, or HRA) which is a confocalModeling of the rhodopsin bleaching with variational analysis of retinal images J. Dobrosotskayaa Memorial Drive, Bethesda, MD 20892 ABSTRACT This paper discusses a variational method of processing

  8. 2005 Special Issue Stochastic resonance in noisy spiking retinal and sensory neuron models*

    E-Print Network [OSTI]

    Kosko, Bart

    2005 Special Issue Stochastic resonance in noisy spiking retinal and sensory neuron models* Ashok Patel, Bart Kosko* Department of Electrical Engineering, Signal and Image Processing Institute of spiking retinal neurons and spiking sensory neurons. The first theorem gives necessary and sufficient

  9. Effects of retinal scattering in the ocular double-pass process

    E-Print Network [OSTI]

    Dainty, Chris

    Effects of retinal scattering in the ocular double-pass process L. Diaz-Santana and J. C. Dainty-pass process is presented. With the help of this description, the relationship between the phase information losses and the statistical properties of retinal scattering is demonstrated. © 2001 Optical Society

  10. Decorrelation of retinal response to natural scenes by fixational eye movements

    E-Print Network [OSTI]

    Rucci, Michele

    to reduce correlations in retinal responses and contribute to visual information processing. retinaDecorrelation of retinal response to natural scenes by fixational eye movements Irina Yonit Segala. It is commonly assumed that the retina processes this input signal efficiently by taking into account

  11. Towards building an anatomically correct solid eye model with volumetric representation of retinal morphology

    E-Print Network [OSTI]

    Hamann, Bernd

    Towards building an anatomically correct solid eye model with volumetric representation of retinal volumetric retinal morphology) has many applications in the field of ophthalmology, including evaluation of ophthalmic instruments and optometry/ophthalmology training. We present a method that uses volumetric OCT

  12. The rp Process Ashes from Stable Nuclear Burning on an Accreting Neutron Star

    E-Print Network [OSTI]

    Hendrik Schatz; Lars Bildsten; Andrew Cumming; Michael Wiescher

    1999-05-20

    We calculate the nucleosynthesis during stable nuclear burning on an accreting neutron star. This is appropriate for weakly magnetic neutron stars accreting at near-Eddington rates in low mass X-ray binaries, and for most accreting X-ray pulsars. We show that the nuclear burning proceeds via the rapid proton capture process (rp process), and makes nuclei far beyond the iron group. The final mixture of nuclei consists of elements with a range of masses between approximately A=60 and A=100. The average nuclear mass of the ashes is set by the extent of helium burning via (alpha,p) reactions, and depends on the local accretion rate. Our results imply that the crust of these accreting neutron stars is made from a complex mixture of heavy nuclei, with important implications for its thermal, electrical and structural properties. A crustal lattice as impure as our results suggest will have a conductivity set mostly by impurity scattering, allowing more rapid Ohmic diffusion of magnetic fields than previously estimated.

  13. Mass Measurements of Very Neutron-Deficient Mo and Tc Isotopes and Their Impact on rp Process Nucleosynthesis

    SciTech Connect (OSTI)

    Haettner, E.; Plass, W. R.; Scheidenberger, C.; Ackermann, D.; Block, M.; Eliseev, S.; Herfurth, F.; Hessberger, F. P.; Hofmann, S.; Kluge, H.-J.; Audi, G.; Blaum, K.; Ketter, J.; Fleckenstein, T.; Ketelaer, J.; Marx, G.; Schweikhard, L.; Mazzocco, M.; Novikov, Yu. N.; Vorobjev, G.

    2011-03-25

    The masses of ten proton-rich nuclides, including the N=Z+1 nuclides {sup 85}Mo and {sup 87}Tc, were measured with the Penning trap mass spectrometer SHIPTRAP. Compared to the Atomic Mass Evaluation 2003 a systematic shift of the mass surface by up to 1.6 MeV is observed causing significant abundance changes of the ashes of astrophysical x-ray bursts. Surprisingly low {alpha} separation energies for neutron-deficient Mo and Tc are found, making the formation of a ZrNb cycle in the rp process possible. Such a cycle would impose an upper temperature limit for the synthesis of elements beyond Nb in the rp process.

  14. Mass measurements of very neutron-deficient Mo and Tc isotopes and their impact on rp process nucleosynthesis

    E-Print Network [OSTI]

    E. Haettner; D. Ackermann; G. Audi; K. Blaum; M. Block; S. Eliseev; T. Fleckenstein; F. Herfurth; F. P. Heßberger; S. Hofmann; J. Ketelaer; J. Ketter; H. -J. Kluge; G. Marx; M. Mazzocco; Yu. N. Novikov; W. R. Plaß; S. Rahaman; T. Rauscher; D. Rodríguez; H. Schatz; C. Scheidenberger; L. Schweikhard; B. Sun; P. G. Thirolf; G. Vorobjev; M. Wang; C. Weber

    2011-03-28

    The masses of ten proton-rich nuclides, including the N=Z+1 nuclides 85-Mo and 87-Tc, were measured with the Penning trap mass spectrometer SHIPTRAP. Compared to the Atomic Mass Evaluation 2003 a systematic shift of the mass surface by up to 1.6 MeV is observed causing significant abundance changes of the ashes of astrophysical X-ray bursts. Surprisingly low alpha-separation energies for neutron-deficient Mo and Tc are found, making the formation of a ZrNb cycle in the rp process possible. Such a cycle would impose an upper temperature limit for the synthesis of elements beyond Nb in the rp process.

  15. Pressure Losses in 12”, 15” and 16” Non-Metallic Flexible Ducts with Compression and Sag (RP-1333) 

    E-Print Network [OSTI]

    Culp, C.H.; Cantrill, D.

    2009-01-01

    is based on findings resulting from ASHRAE Research Project RP-1333. ABSTRACT A study was conducted to measure air pressure loss in non- metallic flexible ducts and included 12” (305 mm), 14” (356 mm) and 16” (406 mm) diameter ducts on a flat surface... and also positioned over joists on 24” (610 mm) centers. For this study, flexible duct compression configurations were fully stretched and 4%, 15%, 30% and 45% compressed. Measure- ments were performed at each compression. All tests were performed...

  16. Blood vessel detection in retinal images and its application in diabetic retinopathy screening 

    E-Print Network [OSTI]

    Zhang, Ming

    2009-05-15

    In this dissertation, I investigated computing algorithms for automated retinal blood vessel detection. Changes in blood vessel structures are important indicators of many diseases such as diabetes, hypertension, etc. Blood vessel is also very...

  17. Reorganization of Visual Processing in Macular Degeneration Is Not Specific to the "Preferred Retinal Locus"

    E-Print Network [OSTI]

    Baker, Chris I.

    Recent work has shown that foveal cortex, deprived of its normal bottom-up input as a result of macular degeneration (MD), begins responding to stimuli presented to a peripheral retinal location. However, these studies ...

  18. Automated Tracing of Horizontal Neuron Processes During Retinal Development

    SciTech Connect (OSTI)

    Kerekes, Ryan A [ORNL; Martins, Rodrigo [St. Jude Children's Research Hospital; Dyer, Michael A [ORNL; Gleason, Shaun Scott [ORNL; Karakaya, Mahmut [ORNL; Davis, Denise [St. Jude Children's Research Hospital

    2011-01-01

    In the developing mammalian retina, horizontal neurons undergo a dramatic reorganization oftheir processes shortly after they migrate to their appropriate laminar position. This is an importantprocess because it is now understood that the apical processes are important for establishing theregular mosaic of horizontal cells in the retina and proper reorganization during lamination isrequired for synaptogenesis with photoreceptors and bipolar neurons. However, this process isdifficult to study because the analysis of horizontal neuron anatomy is labor intensive and time-consuming. In this paper, we present a computational method for automatically tracing the three-dimensional (3-D) dendritic structure of horizontal retinal neurons in two-photon laser scanningmicroscope (TPLSM) imagery. Our method is based on 3-D skeletonization and is thus able topreserve the complex structure of the dendritic arbor of these cells. We demonstrate theeffectiveness of our approach by comparing our tracing results against two sets of semi-automatedtraces over a set of 10 horizontal neurons ranging in age from P1 to P5. We observe an averageagreement level of 81% between our automated trace and the manual traces. This automatedmethod will serve as an important starting point for further refinement and optimization.

  19. Photovoltaic retinal prosthesis: implant fabrication and performance This article has been downloaded from IOPscience. Please scroll down to see the full text article.

    E-Print Network [OSTI]

    Palanker, Daniel

    Photovoltaic retinal prosthesis: implant fabrication and performance This article has been (11pp) doi:10.1088/1741-2560/9/4/046014 Photovoltaic retinal prosthesis: implant fabrication/046014 Abstract The objective of this work is to develop and test a photovoltaic retinal prosthesis for restoring

  20. Shifts in the retinal image of a visual scene during saccades contribute to the perception of reached gaze direction in humans

    E-Print Network [OSTI]

    based on the processing of retinal excitation both before and after the eye movements. q 2003 Elsevier; Target position; Human Evidences are cumulating suggesting that retinal signals influence the processingShifts in the retinal image of a visual scene during saccades contribute to the perception

  1. Robert E. Marc: The Structure of Vertebrate Retinas In: J Toyoda (ed.) The Retinal Basis of Vision

    E-Print Network [OSTI]

    Marc, Robert E.

    Robert E. Marc: The Structure of Vertebrate Retinas In: J Toyoda (ed.) The Retinal Basis of Vision Elsevier, Amsterdam 1998 The Structure of Vertebrate Retinas Robert E. Marc John Moran Eye Center, retinal neurons, neuronal patterning, neuronal stratification Correspondence: Robert E. Marc John Moran

  2. Absolute distance perception during in-depth head movement: calibrating optic flow with extra-retinal information

    E-Print Network [OSTI]

    Fah, Cheong Loong

    Absolute distance perception during in-depth head movement: calibrating optic flow with extra-retinal Processing and Application Laboratory (IPAL-CNRS), KDRL, 21 Heng Mui Keng Terrace, Singapore 119613 d reserved. Keywords: Self-motion; Object-motion; Absolute distance perception; Optic flow; Extra-retinal cue

  3. Effects of Terrain Heights and Sizes on Island-Scale Circulations and Rainfall for the Island of Hawaii during HaRP

    E-Print Network [OSTI]

    Chen, Yi-Leng

    of Hawaii during HaRP YANG YANG AND YI-LENG CHEN Department of Meteorology, SOEST, University of Hawaii at Manoa, Honolulu, Hawaii (Manuscript received 9 August 2006, in final form 23 April 2007) ABSTRACT Islands in Hawaii have different sizes and terrain heights with notable differences in climate and weather

  4. Method and system for the diagnosis of disease using retinal image content and an archive of diagnosed human patient data

    DOE Patents [OSTI]

    Tobin, Kenneth W; Karnowski, Thomas P; Chaum, Edward

    2013-08-06

    A method for diagnosing diseases having retinal manifestations including retinal pathologies includes the steps of providing a CBIR system including an archive of stored digital retinal photography images and diagnosed patient data corresponding to the retinal photography images, the stored images each indexed in a CBIR database using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the stored images. A query image of the retina of a patient is obtained. Using image processing, regions or structures in the query image are identified. The regions or structures are then described using the plurality of feature vectors. At least one relevant stored image from the archive based on similarity to the regions or structures is retrieved, and an eye disease or a disease having retinal manifestations in the patient is diagnosed based on the diagnosed patient data associated with the relevant stored image(s).

  5. Retinal Anatomy and Physiology Vision begins at the retina, where light is converted into

    E-Print Network [OSTI]

    Duong, Timothy Q.

    plexiform layer (IPL), and the gan- glion cell layer (GCL). The signals are transmitted to the fiber nerve is mainly localized in the GCL, but projects capillaries into the INL, IPL, and OPL.1,4,5 The choroidal the retinal pigment epithelium.1,4,5 The thickness of the choroid is reported to be 25­45 m in rats.6

  6. Retinal Target Cells of the Centrifugal Projection from the Isthmo-optic Nucleus

    E-Print Network [OSTI]

    Uchiyama, Hiroyuki

    Retinal Target Cells of the Centrifugal Projection from the Isthmo-optic Nucleus HIROYUKI UCHIYAMA by the axons might be essential for the overall topographic organization of the centrifugal visual system in birds. J. Comp. Neurol. 476:146­153, 2004. © 2004 Wiley-Liss, Inc. Indexing terms: retina; centrifugal

  7. Segmentation of retinal vessels with a hysteresis binary-classification paradigm

    E-Print Network [OSTI]

    Lübeck, Universität zu

    Segmentation of retinal vessels with a hysteresis binary-classification paradigm Alexandru P Building 64 D-23562 Luebeck, Germany Abstract Vessel segmentation in photographies of the retina is needed a paradigm of hysteresis- classifier design that we apply to the problem of vessel segmentation. Before

  8. Adaptive optics retinal imaging in the living Ying Geng,1,2,*

    E-Print Network [OSTI]

    Adaptive optics retinal imaging in the living mouse eye Ying Geng,1,2,* Alfredo Dubra,1,3,4 Lu Yin for Visual Science, University of Rochester, Rochester, NY 14627, USA 2 The Institute of Optics, University@corning.com Abstract: Correction of the eye's monochromatic aberrations using adaptive optics (AO) can improve

  9. Supernormal vision and high-resolution retinal imaging through adaptive optics

    E-Print Network [OSTI]

    Supernormal vision and high-resolution retinal imaging through adaptive optics Junzhong Liang corrected these aberra- tions using adaptive optics, providing normal eyes with supernormal optical quality optics. The eye's aber- rations also limit the resolution of images of the retina, a limit that has

  10. Purification, crystallization and preliminary X-ray diffraction studies of retinal dehydrogenase type II

    E-Print Network [OSTI]

    Lamb, Audrey Lee; Wang, Xianshu; Napoli, Joseph L.; Newcomer, Marcia E.

    1998-07-01

    One enzyme which catalyzes the last step of the formation of the hormone retinoic acid from vitamin A (retinol) is retinal dehydrogenase type II (RalDH2). RalDH2, expressed in the Escherichia coli BL21(DE3) strain, was purified and crystallized...

  11. Decoding the Speed and Motion Direction of Moving Targets Using a Turtle Retinal Patch Model

    E-Print Network [OSTI]

    Ghosh, Bijoy K.

    Decoding the Speed and Motion Direction of Moving Targets Using a Turtle Retinal Patch Model to express my sincerest gratitude to my advisor, Dr. Bijoy Ghosh, whose guidance, advice, encouragement and support made my research possible at the Center for BioCybernetis and Intelligent Systems (CBCIS

  12. Communication: One-photon phase control of cis-trans isomerization in retinal

    SciTech Connect (OSTI)

    Arango, Carlos A.; Brumer, Paul

    2013-02-21

    We computationally demonstrate the one-photon phase control of retinal isomerization under conditions of low laser intensity. The calculations, utilizing the multiconfigurational time dependent Hartree method, include coupling between the two modes that are active in isomerization and the background molecular vibrational environment. Noting previously unsuccessful computations highlights the significance of this result.

  13. Retinal Pigment Epithelial (RPE) Verification of melanin function as a light activated ROS scavenger

    E-Print Network [OSTI]

    role in protecting our skin from the damaging effects of UV radiation and in preventing skin cancer officinalis, a species of cuttlefish, were added to cultured human retinal pigment epithelial (RPE) cells only native melanin. These experiments conclusively demonstrate that melanin serves as a light

  14. Cellular/Molecular Intrinsic ON Responses of the Retinal OFF Pathway Are

    E-Print Network [OSTI]

    Stryker, Michael

    -0874, Japan Parallel ON and OFF pathways conduct visual signals from bipolar cells in the retina to higher-latencyONresponsesareinitiatedintheOFFpathways.Ourresultsexposeapreviouslyunrecognizedintrinsic property of OFF retinal pathways that generates responses to light onset. In mGluR6-null mice, long and the associated b-wave of the flash electroretinogram (ERG) [mouse (Green et al., 2004); rabbit (Massey et al

  15. Improvement of in-vivo en-face OCT retinal images using adaptive optics

    E-Print Network [OSTI]

    Dainty, Chris

    Improvement of in-vivo en-face OCT retinal images using adaptive optics D. Merinoa, A. Bradub, C an adaptive optics closed-loop system that uses a Shack-Hartmann wavefront sensor and a 37 OKO membrane the reference and object arm is used to determine the amount of light reflected back from a certain point within

  16. PROGRESS TOWARDS A HIGH-RESOLUTION RETINAL PROSTHESIS James D. Weiland1

    E-Print Network [OSTI]

    Arizona, University of

    PROGRESS TOWARDS A HIGH-RESOLUTION RETINAL PROSTHESIS James D. Weiland1 , Wolfgang Fink2,1 , Mark of image processing, microelectronics, and polymer based electrodes and interconnects. An image processing and tested to demonstrate closed loop power control and efficient microstimulation. A novel packaging process

  17. International Conference Mathematical and Computational Biology 2011 International Journal of Modern Physics: Conference Series

    E-Print Network [OSTI]

    Bargiela, Andrzej

    : Retina; retinal prosthesis; vision; image processing; neural computation. #12;210 T. T. Kien, T. Maul.1142/S2010194512005272 209 A REVIEW OF RETINAL PROSTHESIS APPROACHES TRAN TRUNG KIEN School of Computer-related macular degeneration and retinitis pigmentosa are two of the most common diseases that cause degeneration

  18. 1) The snow plow problem (R.P. Agnew): It began to snow early in the morning and the snow continued to fall throughout the

    E-Print Network [OSTI]

    Prigozhin, Leonid

    1) The snow plow problem (R.P. Agnew): It began to snow early in the morning and the snow continued to fall throughout the day at a constant rate. Assume that the speed at which a snow plow is able to clear a road is inversely proportional to the height of the snow. The snow plow started at 5 a.m. and had

  19. ARM - Datastreams - rp

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Comments? We wouldDatastreamsnoaaradbrw Documentation XDC documentation DataDatastreamspwsDatastreamsrp

  20. Clinical and Experimental Optometry 88.5 September 2005 Retinal remodelling Jones, Watt and Marc

    E-Print Network [OSTI]

    Marc, Robert E.

    and Marc OPTOMETRY C L I N I C A L A N D E X P E R I M E N T A L Clin Exp Optom 2005; 88: 5: 282D Robert E Marc PhD Moran Eye Center, School of Medicine, University of Utah, Salt Lake City, USA Submitted and Experimental Optometry 88.5 September 2005 283 Retinal remodelling Jones, Watt and Marc dystrophies

  1. Slow Feature Analysis on Retinal Waves Leads to V1 Complex Cells

    E-Print Network [OSTI]

    Wiskott, Laurenz

    Slow Feature Analysis on Retinal Waves Leads to V1 Complex Cells Sven Da¨hne1,2,3 *, Niko Wilbert2 such that it is best prepared for coding input from the natural world. Citation: Da¨hne S, Wilbert N, Wiskott L (2014 Received June 25, 2013; Accepted December 20, 2013; Published May 8, 2014 Copyright: ß 2014 Da¨hne et al

  2. L3:THM.CFD.P5.02 J.N. Shadid, T.M. Smith, R.P. Pawlowski, E. C. Cyr,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse Bergkamp Graduate student Subtask2 J.N. Shadid, T.M. Smith, R.P.

  3. Proceedings of International Joint Conference on Neural Networks, Atlanta, Georgia, USA, June 14-19, 2009 Fast and Accurate Retinal Vasculature Tracing and

    E-Print Network [OSTI]

    that require real time processing. In order to extract the retinal vessels in real time, we propose a fast-19, 2009 Fast and Accurate Retinal Vasculature Tracing and Kernel-Isomap-based Feature Selection Donghyeop tracing algorithms based on a detailed analysis of the image can be too slow to quickly process a large

  4. An Effective Approach to Detect Lesions in Color Retinal Images1 Huan Wang, Wynne Hsu, Kheng Guan Goh, Mong Li Lee

    E-Print Network [OSTI]

    Lee, Mong Li "Janice"

    1 An Effective Approach to Detect Lesions in Color Retinal Images1 Huan Wang, Wynne Hsu, Kheng Guan screenings. To lower the cost of such screenings, we employ state-of-the-art image processing techniques to automatically detect the presence of abnormalities in the retinal images obtained during the screenings

  5. High-resolution retinal imaging using adaptive optics and Fourier-domain optical coherence tomography

    DOE Patents [OSTI]

    Olivier, Scot S. (Livermore, CA); Werner, John S. (Davis, CA); Zawadzki, Robert J. (Sacramento, CA); Laut, Sophie P. (Pasedena, CA); Jones, Steven M. (Livermore, CA)

    2010-09-07

    This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4.times.4.times.6 .mu.m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

  6. Retinal instrument

    SciTech Connect (OSTI)

    Britton, Charles L; D& #x27; Urso, Brian R; Chaum, Edward; Simpson, John T; Baba, Justin S; Ericson, M. Nance; Warmack, Robert J

    2013-04-23

    In one embodiment, the present invention provides a method of removing scar tissue from an eye that includes inserting a device including an array of micro-rods into an eye, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature; contacting a scar tissue with the array of micro-rods; and removing the array of micro-rods and the scar tissue from the eye. In another embodiment, the present invention provides a medical device for engaging a tissue including and an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods that is connected to the cannula, wherein the sharp feature of the at least one micro-rod is angled from a plane that is normal to a face of the base of the array of glass micro-rods.

  7. Retinal Ganglion

    E-Print Network [OSTI]

    The third mechanism model, FCM model, consists of five ion channels ... of a maximum rate constant (“g bar”), a value proportional to some combination of the

  8. Honeybee retinal glial cells transform glucose and supply the neurons with metabolic substrate

    SciTech Connect (OSTI)

    Tsacopoulos, M.; Evequoz-Mercier, V.; Perrottet, P.; Buchner, E.

    1988-11-01

    The retina of the honeybee drone is a nervous tissue in which glial cells and photoreceptor cells (sensory neurons) constitute two distinct metabolic compartments. Retinal slices incubated with 2-deoxy(/sup 3/H)glucose convert this glucose analogue to 2-deoxy(/sup 3/H)glucose 6-phosphate, but this conversion is made only in the glial cells. Hence, glycolysis occurs only in glial cells. In contrast, the neurons consume O/sub 2/ and this consumption is sustained by the hydrolysis of glycogen, which is contained in large amounts in the glia. During photostimulation the increased oxidative metabolism of the neurons is sustained by a higher supply of carbohydrates from the glia. This clear case of metabolic interaction between neurons and glial cells supports Golgi's original hypothesis, proposed nearly 100 years ago, about the nutritive function of glial cells in the nervous system.

  9. Blood flow measurement and slow flow detection in retinal vessels with Joint Spectral and Time domain method in ultrahigh speed OCT

    E-Print Network [OSTI]

    Gorczynska, Iwona

    We present an application of the Joint Spectral and Time domain OCT (STdOCT) method for detection of wide range of flows in the retinal vessels. We utilized spectral/Fourier domain OCT (SOCT) technique for development of ...

  10. Early-Stage Waves in the Retinal Network Emerge Close to a Critical State Transition between Local and Global Functional Connectivity 

    E-Print Network [OSTI]

    Hennig, M H; Willshaw, David; Adams, C; Sernagor, E

    2009-01-28

    A novel, biophysically realistic model for early-stage, acetylcholine-mediated retinal waves is presented. In this model, neural excitability is regulated through a slow after-hyperpolarization (sAHP) operating on two ...

  11. Nuclear translocation and overexpression of GAPDH by the hyper-pressure in retinal ganglion cell

    SciTech Connect (OSTI)

    Kim, Choong-Il; Lee, Sung-Ho; Seong, Gong-Je; Kim, Yeon-Hyang; Lee, Mi-Young . E-mail: miyoung@sch.ac.kr

    2006-03-24

    To investigate the effect of hyper-pressure on retinal ganglion cells (RGC-5), RGC-5 cells were exposed to an ambient hydrostatic pressure of 100 mm Hg. Upon treatment, the proliferation of RGC-5 cells was inhibited and neuronal apoptosis was detected by specific apoptosis marker TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling). To probe into the mechanism mediating the apoptosis of RGC-5 cells in 100 mm Hg, protein profile alterations following hyper-pressure treatment were examined using two-dimensional gel electrophoresis (2-DE) followed by MALDI-TOF. Out of the 400 protein spots of RGC-5 cells detected on 2-DE gels, 37 differentially expressed protein spots were further identified using in gel tryptic digestion and mass spectrometry. Among these proteins, glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) was significantly expressed 10 times more in 100 mm Hg than in normal pressure. The accumulation of GAPDH in the nucleus and its translocation from the cytosol to the nucleus in 100 mm Hg were observed using a microscope. These results suggest that the hyper-pressure-induced apoptosis in RGC-5 cells may be involved with not only the increase of GAPDH expression, but also the accumulation and the translocalization of GAPDH to the nucleus.

  12. DOE FINAL TECHNICAL REPORT RP

    SciTech Connect (OSTI)

    RUSS PETERMAN

    2012-01-01

    The City of Georgetown Utility Systems (GUS) patnered with the private sector, the American Public Power Association (APPA) and Southwestern University to design, construct, test and monitor a solar co-generation system directly connected to the GUS electric distribution system. This report consists of the Primary Technical Report and 3 attachments.

  13. if020rp6.PDF

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematics And Statistics » USAJobsMotion to Withdraw | DepartmentSuite 600, 1901 North Moore

  14. Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development

    E-Print Network [OSTI]

    Lin, Andrew C; Tan, Chin Lik; Lin, Chien-Ling; Strochlic, Laure; Huang, Yi-Shuian; Richter, Joel D; Holt, Christine E

    2009-03-02

    ) RFP/RBM-transfected embryos have bright RFP-positive axons in the optic pathway projecting correctly to the tectum, while RFP/AA-transfected embryos do not. Scale bars: 65 ?m (A, B, M, N); 10 ?m (D, F, J, K); 5 ?m (I). Blue, DAPI; green, CPEB1-GFP... AcceCResearch article Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development Andrew C Lin1,3, Chin Lik Tan1,4, Chien-Ling Lin2, Laure Strochlic1,5, Yi- Shuian...

  15. Reconstruction 3-dimensional image from 2-dimensional image of status optical coherence tomography (OCT) for analysis of changes in retinal thickness

    SciTech Connect (OSTI)

    Arinilhaq,; Widita, Rena [Department of Physics, Nuclear Physics and Biophysics Research Group, Institut Teknologi Bandung (Indonesia)

    2014-09-30

    Optical Coherence Tomography is often used in medical image acquisition to diagnose that change due easy to use and low price. Unfortunately, this type of examination produces a two-dimensional retinal image of the point of acquisition. Therefore, this study developed a method that combines and reconstruct 2-dimensional retinal images into three-dimensional images to display volumetric macular accurately. The system is built with three main stages: data acquisition, data extraction and 3-dimensional reconstruction. At data acquisition step, Optical Coherence Tomography produced six *.jpg images of each patient were further extracted with MATLAB 2010a software into six one-dimensional arrays. The six arrays are combined into a 3-dimensional matrix using a kriging interpolation method with SURFER9 resulting 3-dimensional graphics of macula. Finally, system provides three-dimensional color graphs based on the data distribution normal macula. The reconstruction system which has been designed produces three-dimensional images with size of 481 × 481 × h (retinal thickness) pixels.

  16. Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis

    SciTech Connect (OSTI)

    Pourgholami, Mohammad H.; Khachigian, Levon M.; Fahmy, Roger G.; Badar, Samina; Wang, Lisa; Chu, Stephanie Wai Ling; Morris, David Lawson

    2010-07-09

    The angiogenic process begins with the cell proliferation and migration into the primary vascular network, and leads to vascularization of previously avascular tissues and organs as well to growth and remodeling of the initially homogeneous capillary plexus to form a new microcirculation. Additionally, an increase in microvascular permeability is a crucial step in angiogenesis. Vascular endothelial growth factor (VEGF) plays a central role in angiogenesis. We have previously reported that albendazole suppresses VEGF levels and inhibits malignant ascites formation, suggesting a possible effect on angiogenesis. This study was therefore designed to investigate the antiangiogenic effect of albendazole in non-cancerous models of angiogenesis. In vitro, treatment of human umbilical vein endothelial cells (HUVECs) with albendazole led to inhibition of tube formation, migration, permeability and down-regulation of the VEGF type 2 receptor (VEGFR-2). In vivo albendazole profoundly inhibited hyperoxia-induced retinal angiogenesis in mice. These results provide new insights into the antiangiogenic effects of albendazole.

  17. TGF-{beta}-stimulated aberrant expression of class III {beta}-tubulin via the ERK signaling pathway in cultured retinal pigment epithelial cells

    SciTech Connect (OSTI)

    Chung, Eun Jee [Department of Ophthalmology, National Health Insurance Corporation Ilsan Hospital, Gyeonggi-do (Korea, Republic of)] [Department of Ophthalmology, National Health Insurance Corporation Ilsan Hospital, Gyeonggi-do (Korea, Republic of); Chun, Ji Na; Jung, Sun-Ah [Konyang University Myunggok Medical Research Institute, Kim's Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of)] [Konyang University Myunggok Medical Research Institute, Kim's Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of); Cho, Jin Won [Department of Biology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749 (Korea, Republic of)] [Department of Biology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Lee, Joon H., E-mail: joonhlee@konyang.ac.kr [Konyang University Myunggok Medical Research Institute, Kim's Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of)

    2011-11-18

    Highlights: Black-Right-Pointing-Pointer TGF-{beta} induces aberrant expression of {beta}III in RPE cells via the ERK pathway. Black-Right-Pointing-Pointer TGF-{beta} increases O-GlcNAc modification of {beta}III in RPE cells. Black-Right-Pointing-Pointer Mature RPE cells have the capacity to express a neuron-associated gene by TGF-{beta}. -- Abstract: The class III {beta}-tubulin isotype ({beta}{sub III}) is expressed exclusively by neurons within the normal human retina and is not present in normal retinal pigment epithelial (RPE) cells in situ or in the early phase of primary cultures. However, aberrant expression of class III {beta}-tubulin has been observed in passaged RPE cells and RPE cells with dedifferentiated morphology in pathologic epiretinal membranes from idiopathic macular pucker, proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR). Transforming growth factor-{beta} (TGF-{beta}) has been implicated in dedifferentiation of RPE cells and has a critical role in the development of proliferative vitreoretinal diseases. Here, we investigated the potential effects of TGF-{beta} on the aberrant expression of class III {beta}-tubulin and the intracellular signaling pathway mediating these changes. TGF-{beta}-induced aberrant expression and O-linked-{beta}-N-acetylglucosamine (O-GlcNac) modification of class III {beta}-tubulin in cultured RPE cells as determined using Western blotting, RT-PCR and immunocytochemistry. TGF-{beta} also stimulated phosphorylation of ERK. TGF-{beta}-induced aberrant expression of class III {beta}-tubulin was significantly reduced by pretreatment with U0126, an inhibitor of ERK phosphorylation. Our findings indicate that TGF-{beta} stimulated aberrant expression of class III {beta}-tubulin via activation of the ERK signaling pathway. These data demonstrate that mature RPE cells have the capacity to express a neuron-associated gene in response to TGF-{beta} stimulation and provide useful information towards understanding the pathogenesis of proliferative vitreoretinal diseases.

  18. Cholesterol enhances amyloid {beta} deposition in mouse retina by modulating the activities of A{beta}-regulating enzymes in retinal pigment epithelial cells

    SciTech Connect (OSTI)

    Wang, Jiying [Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 (Japan)] [Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 (Japan); Ohno-Matsui, Kyoko, E-mail: k.ohno.oph@tmd.ac.jp [Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 (Japan)] [Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 (Japan); Morita, Ikuo [Section of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 (Japan)] [Section of Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 (Japan)

    2012-08-10

    Highlights: Black-Right-Pointing-Pointer Cholesterol-treated RPE produces more A{beta} than non-treated RPE. Black-Right-Pointing-Pointer Neprilysin expression and activity decreased in cholesterol-treated RPE. Black-Right-Pointing-Pointer {alpha}-Secretase expression and activity decreased in cholesterol-treated RPE. Black-Right-Pointing-Pointer Cholesterol-enriched diet induced subRPE deposits in aged mice. Black-Right-Pointing-Pointer A{beta} were present in cholesterol-enriched-diet-induced subRPE deposits in aged mice. -- Abstract: Subretinally-deposited amyloid {beta} (A{beta}) is a main contributor of developing age-related macular degeneration (AMD). However, the mechanism causing A{beta} deposition in AMD eyes is unknown. Hypercholesterolemia is a significant risk for developing AMD. Thus, we investigated the effects of cholesterol on A{beta} production in retinal pigment epithelial (RPE) cells in vitro and in the mouse retina in vivo. RPE cells isolated from senescent (12-month-old) C57BL/6 mice were treated with 10 {mu}g/ml cholesterol for 48 h. A{beta} amounts in culture supernatants were measured by ELISA. Activity and expression of enzymes and proteins that regulate A{beta} production were examined by activity assay and real time PCR. The retina of mice fed cholesterol-enriched diet was examined by transmission electron microscopy. Cholesterol significantly increased A{beta} production in cultured RPE cells. Activities of A{beta} degradation enzyme; neprilysin (NEP) and anti-amyloidogenic secretase; {alpha}-secretase were significantly decreased in cell lysates of cholesterol-treated RPE cells compared to non-treated cells, but there was no change in the activities of {beta}- or {gamma}-secretase. mRNA levels of NEP and {alpha}-secretase (ADAM10 and ADAM17) were significantly lower in cholesterol-treated RPE cells than non-treated cells. Senescent (12-month-old) mice fed cholesterol-enriched chow developed subRPE deposits containing A{beta}, whereas age-matched mice fed standard rodent chow diet did not. Activities and mRNA levels of NEP and {alpha}-secretase were significantly lower in native RPE cells freshly isolated from cholesterol-enriched chow fed mice compared to standard rodent chow fed mice. These findings suggest that cholesterol enhances subretinal A{beta} accumulation by modulating the activities of enzymes degrading and processing A{beta} in RPE cells in senescent subjects.

  19. DE-RP05-01OR22717

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submit theCovalent Bonding Low-Cost Ground8 Gas Hydrate CharacterizationTBD Notice

  20. GVB RP: A Reliable MCSCF Wave Function for Large Systems

    E-Print Network [OSTI]

    Goddard III, William A.

    DURIP; BP Chemical; ARO; Exxon; Seiko-Epson; Owens Corning; Asahi Chemical, Saudi Aramco; Beckman Institute

  1. SRO-N E RP-12 ,/-:.:;:"Yj$~~-'

    E-Print Network [OSTI]

    Georgia, University of

    Catostomidae - Sucker Family Key to Species of Family Catostomidae Order Siluri formes I ctaluridae - Catfish

  2. 16.810 Design and RP Introduction to idea sketching

    E-Print Network [OSTI]

    de Weck, Olivier L.

    and visual memory basic structure proportion necessary details #12;Technique Rule number 1 no postage stamps Skills drawing basic shapes Method to represent 3D objects in 2D #12;Ideation Sketching #12;Idea Exploration Engineering style #12;Goal In a few weeks ...in 5-10 minutes #12;Sketching Philosophy Technique

  3. IDC RP2 & 3 US Industry Standard Cost Estimate Summary.

    SciTech Connect (OSTI)

    Harris, James M.; Huelskamp, Robert M.

    2015-01-01

    Sandia National Laboratories has prepared a ROM cost estimate for budgetary planning for the IDC Reengineering Phase 2 & 3 effort, using a commercial software cost estimation tool calibrated to US industry performance parameters. This is not a cost estimate for Sandia to perform the project. This report provides the ROM cost estimate and describes the methodology, assumptions, and cost model details used to create the ROM cost estimate. ROM Cost Estimate Disclaimer Contained herein is a Rough Order of Magnitude (ROM) cost estimate that has been provided to enable initial planning for this proposed project. This ROM cost estimate is submitted to facilitate informal discussions in relation to this project and is NOT intended to commit Sandia National Laboratories (Sandia) or its resources. Furthermore, as a Federally Funded Research and Development Center (FFRDC), Sandia must be compliant with the Anti-Deficiency Act and operate on a full-cost recovery basis. Therefore, while Sandia, in conjunction with the Sponsor, will use best judgment to execute work and to address the highest risks and most important issues in order to effectively manage within cost constraints, this ROM estimate and any subsequent approved cost estimates are on a 'full-cost recovery' basis. Thus, work can neither commence nor continue unless adequate funding has been accepted and certified by DOE.

  4. CRAD, NNSA - Radiation Protection (RP) | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirley Ann Jackson About UsEnergy MarketingAsset Score00.4| Department of Energy FederalRadiation

  5. CHAPTER: In-Situ Characterization of Stimulating Microelectrode Arrays: Study of an Idealized Structure Based on Argus II Retinal implantsBOOK TITLE: Implantable Neural Prostheses 2: Techniques and Engineering Approaches, D.M. Zhou and E. Greenbaum, Eds., Springer, NY 2009

    SciTech Connect (OSTI)

    Greenbaum, Elias [ORNL; Sanders, Charlene A [ORNL; Kandagor, Vincent [ORNL

    2010-01-01

    The development of a retinal prosthesis for artificial sight includes a study of the factors affecting the structural and functional stability of chronically implanted microelectrode arrays. Although neuron depolarization and propagation of electrical signals have been studied for nearly a century, the use of multielectrode stimulation as a proposed therapy to treat blindness is a frontier area of modern ophthalmology research. Mapping and characterizing the topographic information contained in the electric field potentials and understanding how this information is transmitted and interpreted in the visual cortex is still very much a work in progress. In order to characterize the electrical field patterns generated by the device, an in vitro prototype that mimics several of the physical and chemical parameters of the in vivo visual implant device was fabricated. We carried out multiple electrical measurements in a model 'eye,' beginning with a single electrode, followed by a 9-electrode array structure, both idealized components based on the Argus II retinal implants. Correlating the information contained in the topographic features of the electric fields with psychophysical testing in patients may help reduce the time required for patients to convert the electrical patterns into graphic signals.

  6. REVERSIBLE THERMOSENSITIVE GLUE FOR RETINAL IMPLANTS

    E-Print Network [OSTI]

    Meng, Ellis

    . Methods: Polyimide (50 m), parylene C [poly(monochloro-p-xylylene)] (20 m), and poly(dimethyl siloxane three types of base materials: polyimide, parylene C [poly(monochloro-p-xylylene)], and poly- (dimethyl of the epiretinal electrode for epiretinal stimulation. Polyimide was prepared as 50 m thick films, parylene as 20

  7. Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration

    E-Print Network [OSTI]

    Seiler, MJ; Jones, BW; Aramant, RB; Yang, PB; Keirstead, HS; Marc, RE

    2012-01-01

    nuclei; 10 seconds of uranyl acetate stain. (B) Enlargementto ribbon synapse. Ten seconds of uranyl acetate stain. (E)adjacent section. Ten seconds of uranyl acetate stain. (G)

  8. Progress in Retinal and Eye Research, In Press Retinal Connectomics: Towards Complete, Accurate Networks

    E-Print Network [OSTI]

    Marc, Robert E.

    den Heuvel and Sporns, 2011), mesoscale optical studies of connections between defined brain regions

  9. Inner retinal preservation in rat models of retinal degeneration implanted with subretinal photovoltaic arrays

    E-Print Network [OSTI]

    Palanker, Daniel

    photovoltaic arrays Jacob G. Light a, b , James W. Fransen c , Adewumi N. Adekunle a , Alice Adkins b , Gobinda: Retina Prosthetic Bipolar cells Amacrine cells Müller glial cells a b s t r a c t Photovoltaic arrays

  10. Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance 

    E-Print Network [OSTI]

    Manuel, M.; Pratt, T.; Liu, M.; Jeffery, G.; Price, D. J.

    errors in intraretinal navigation by RGC axons, a decrease in the number of RGC axons reaching the thalamus and an increase in the proportion of ipsilateral projections among those RGC axons that do reach the thalamus. A survey of embryos with different...

  11. Low-lying levels in Cu-57 and the rp process 

    E-Print Network [OSTI]

    Zhou, XG; Dejbakhsh, H.; Gagliardi, Carl A.; Jiang, J.; Trache, L.; Tribble, Robert E.

    1996-01-01

    , and 2398 +/- 10 keV. The results are compared with well known excited states of the mirror nucleus Ni-57. Th, measured excited states of Cu-57 allow recalculation of the astrophysical reaction rate for the stellar radiative proton capture reaction Ni-56(p...

  12. Static Pressure Losses in 6 in., 8 in., and 10 in. Nonmetallic Flexible Duct (RP-1333) 

    E-Print Network [OSTI]

    Weaver, K.; Culp, C.H.

    2007-01-01

    with permission of the copyright owner. Further reproduction prohibited without permission. Static Pressure Losses in Nonmetallic Flexible Duct Weaver, Kevin;Culp, Charles ASHRAE Transactions; 2007; 113, ProQuest pg. 400 Reproduced with permission...

  13. Discovering Hierarchical Process Models R.P. Jagadeesh Chandra Bose1,2

    E-Print Network [OSTI]

    van der Aalst, Wil

    ) with domain significance. Keywords: process discovery, process maps, hierarchical models, ab- stractions approach to process discovery and our two-phase approach. Note that the process model (map) discovered the discovery of hi- erarchical process models. In this paper, we demonstrate the discovery of hierar- chical

  14. Capture reactions into borromean two-proton systems at rp-waiting points

    E-Print Network [OSTI]

    D. Hove; A. S. Jensen; H. O. U. Fynbo; N. T. Zinner; D. V. Fedorov; E. Garrido

    2015-07-07

    We investigate even-even two-proton borromean systems at prominent intermediate heavy waiting points for the rapid proton capture process. The most likely single-particle levels are used to calculate three-body energy and structure as a function of proton-core resonance energy. We establish a linear dependence between two- and three-body energies with the same slope, but the absolute value slightly dependent on partial wave structure. Using these relations we predict low-lying excited states in the isotones following the critical waiting points. The capture rate for producing a borromean bound state is described both based on a full three-body calculation and on a very simple analytic rate expression for temperatures about $1-5$~GK. This rate is valid for both direct and sequential capture paths, and it only depends on the three-body resonance energy. As a result the relevant path of the radiative capture reactions can be determined. We present numerical results for $E1$ and $E2$ photon emission, and discuss occurrence preferences in general as well as relative sizes of these most likely processes. Finally, we present narrow estimated intervals for the proton capture rates relevant for the critical waiting points.

  15. Capture reactions into borromean two-proton systems at rp-waiting points

    E-Print Network [OSTI]

    Hove, D; Fynbo, H O U; Zinner, N T; Fedorov, D V; Garrido, E

    2015-01-01

    We investigate even-even two-proton borromean systems at prominent intermediate heavy waiting points for the rapid proton capture process. The most likely single-particle levels are used to calculate three-body energy and structure as a function of proton-core resonance energy. We establish a linear dependence between two- and three-body energies with the same slope, but the absolute value slightly dependent on partial wave structure. Using these relations we predict low-lying excited states in the isotones following the critical waiting points. The capture rate for producing a borromean bound state is described both based on a full three-body calculation and on a very simple analytic rate expression for temperatures about $1-5$~GK. This rate is valid for both direct and sequential capture paths, and it only depends on the three-body resonance energy. As a result the relevant path of the radiative capture reactions can be determined. We present numerical results for $E1$ and $E2$ photon emission, and discuss ...

  16. Effects of Diffuser Airflow Minima on Occupant Comfort, Air Mixing, and Building Energy Use (RP-1515)

    E-Print Network [OSTI]

    2015-01-01

    and Environment 45(1): 29 – Science and Technology for theScience and Technology for the Built Environment, July 2015Science and Technology for the Built Environment, July 2015

  17. CBFO:AMO:RP:GS:05-0217:UFC 5486.00 Department of Energy

    E-Print Network [OSTI]

    Recertification Application (CRA) performance assessment calculations for the Waste Isolation Pilot Plant (WIPP the definition of TRU waste set forth in the WIPP Land Withdrawal Act (LWA) of 1992, P. L. No. 102-579, 106 Stat. 4777, as amended by the WIPP LWA Amendments of 1996, P. L. 104-201, 110 Stat. 2422. Those wastes should

  18. A Coupled Airflow-and-Energy Simulation Program for Indoor Thermal Environment Studies (RP-927)

    E-Print Network [OSTI]

    Chen, Qingyan "Yan"

    for the design of radiative, convective, and hybrid heating and cooling systems. Keywords: Airflow, Air with convective, radiative, and hybrid heating and cooling systems. In the past few years, many investigations for thermal comfort (ASHRAE 1992). In an indoor space with radiative, convective, and hybrid heating

  19. Qualification of Fan Generated Duct Rumble Noise: Part 1: Test Facility(RP 1219) 

    E-Print Network [OSTI]

    Kading, J.; Mann, A.; Pate, M.B.

    2008-01-01

    :4. The transition was enclosed in a 53” by 93” by 3’ tall box constructed from MDF and lined with 2” duct board fiber- glass. The box was designed to isolate the transition duct from break in noise from the fan room. The fiberglass insulation on the inside... (MDF) shell that was mounted on a 2x4 structure. The interior consisted of three layers. The first was fiberglass board 2’x 4’ x 2”, these boards were cut to be stacked and fill in between the MDF and the duct lining insu- lation. The second layer...

  20. Effects of Diffuser Airflow Minima on Occupant Comfort, Air Mixing, and Building Energy Use (RP-1515)

    E-Print Network [OSTI]

    2015-01-01

    in buildings that reduce energy by reducing minimum airflowAdvanced variable air volume (VAV) systems. Energy DesignResources, California Energy Commission. Taylor S, Stein T,

  1. Alpha Emission Near 100Sn and the Termination of the rp Process

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O O D S TA I N P A T TSorbentsAllosteric ModulationAlpha

  2. Request for Proposals (RFP) Number DE-RP36-07GO97036: Alliance Prime

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Financing Tool FitsProject DevelopsforReporting Occupational Radiation|

  3. Microsoft PowerPoint - NA-RP_Public_Workshop_April-2013.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines light on darkMicroorganismsnow widelySmall Ice CrystalsHighMorgantown

  4. Savannah River Site Land Use Plan - May, 2013 i SRNS-RP-2013-00162

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory ofDidDevelopment Top LDRDUniversity PartnershipsSavannah River Site

  5. Microsoft Word - 2015-03-17_FINALRev0_SRNL-RP-2014-01198c

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i nAand DOE Safetyof MethaneMillion Electric VehiclesFirst Quarter Overall

  6. DE-RP05-08OR23286 SOLICITATION, OFFER AND AWARD 4. TYPE OF SOLICITATION

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p aDepartmentEnergyEveryCustomerD= DOE/RG-0067 o yNo. 2.OTHER

  7. Microsoft Word - 2015-03-17_FINALRev0_SRNL-RP-2014-01198c

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJessework uses concrete and realistic microscopicWednesday, AugustMayTechnical

  8. Golden Reading Room: Request for Proposals (RFP) Number DE-RP36-07GO97036 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuelsof Energy Services »Information1

  9. On the Detection of Retinal Vessels in Fundus Images

    E-Print Network [OSTI]

    Fang, Bin

    Ocular fundus image can provide information on pathological changes caused by local ocular diseases and early signs of certain systemic diseases. Automated analysis and interpretation of fundus images has become a necessary ...

  10. Neuronal Circuitry of the Local Edge Detector Retinal Ganglion Cell

    E-Print Network [OSTI]

    Russell, Thomas Lee

    2010-01-01

    Artificial Project. 15. Marr, D. , and Hildreth, E. (1980).perpendicular to it. Marr points out that the logicalsizes is a requirement for Marr and Hildreth?s theory of

  11. Segmentation, registration,and selective watermarking of retinal images 

    E-Print Network [OSTI]

    Wu, Di

    2006-08-16

    vessels, microaneurysms, hemorrhages, exudates, etc.) that are pathologically important and have close resemblance in shapes and colors. To attack this complex subject, I developed a divide-and-conquer strategy to address related issues step...

  12. Polarization and orientation of retinal ganglion cells in vivo

    E-Print Network [OSTI]

    Zolessi, Flavio R.; Poggi, Lucia; Wilkinson, Christopher J.; Chien, Chi-Bin; Harris, William A.

    2006-10-13

    laboratory: Tg(pBatoh7:gap43-gfp)cb1 ('ath5:gap-gfp') and Tg(pBatoh7:gap43-rfp)cb2 ('ath5:gap-rfp'). They express a fluorescent protein (enhanced green fluorescent protein (EGFP) or monomeric red fluorescent protein 1 (mRFP1), respectively) fused to the GAP43... -EGFP in RGCs could be obtained, namely nokm227 × Tg(pBatoh7:gap43-gfp)cb1 and hasm567 × Tg(pBatoh7:gap43-gfp)cb1.Page 2 of 21 (page number not for citation purposes) they stabilize one as the axon. Neural Development 2006, 1:2 http...

  13. Compilation of Diversity Factors and Schedules for Energy and Cooling Load Calculations, ASHRAE Research Project 1093-RP, Final Report 

    E-Print Network [OSTI]

    Abushakra, B.; Sreshthaputra, A.; Haberl, J. S.; Claridge, D. E.

    2001-01-01

    from the diversity factors are then compared with the EUI?s calculated directly from the raw data (Total kWh per year divided by the square footage) to assure that the data manipulation during the derivation of the diversity factors is free...

  14. Applied Mathematical Sciences, Vol. 3, 2009, no. 54, 2703 -2706 The Limit of the Statistic R/P in Models

    E-Print Network [OSTI]

    Stark, Dudley

    to predict that the peak of oil production in the U.S.A. would occur between 1965 and 1970. Oil produc- tion for the U.S.A actually peaked in 1970. In Hubbert's analysis the profile for oil production is approximated/P in Models of Oil Discovery and Production Dudley Stark School of Mathematical Sciences Queen Mary

  15. Developmental arrest of T cells in RpL22-deficient mice is dependent upon multiple p53 effectors

    E-Print Network [OSTI]

    Stadanlick, Jason E.

    alpha beta and gamma delta lineage T cells are thought to arise from a common CD4–CD8– progenitor in the thymus. However, the molecular pathways controlling fate selection and maturation of these two lineages remain poorly ...

  16. Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study

    E-Print Network [OSTI]

    2013-01-01

    may change the retinal bioenergetics and play a significantmay change retinal bioenergetics and energy production

  17. Development and Assessment of Gene Therapies for

    E-Print Network [OSTI]

    Kolstad, Kathleen Durgin

    2009-01-01

    the restoration of retinal processing between bipolar andoverride early stage retinal processing, or lack there of inand a degree of retinal processing, as shown by recordings

  18. Testing neural mechanisms that may underlie spatiotopic processing in area MT

    E-Print Network [OSTI]

    Ong, Wei Song

    2012-01-01

    Hence if motion processing occurs in retinal coordinates, wethat show motion processing do so in retinal coordinates, wein retinal coordinates, can have spatiotopic processing. In

  19. Computational models of early visual processing layers

    E-Print Network [OSTI]

    Shan, Honghao

    2010-01-01

    prevailing view of retinal processing. However, as discussedsimplified) model of retinal processing. A Retinal Codingretinal coding, the pre-cortical stage of visual processing,

  20. Radiation Characteristics of Chlamydomonas reinhardtii CC125 and Its Truncated Chlorophyll Antenna Transformants tla1, tlaX, and 37RP1-tla1

    E-Print Network [OSTI]

    Berberoglu, Halil; Pilon, Laurent; Melis, Anastasios

    2008-01-01

    issues limiting the solar energy conversion e?ciency [8–12].and low solar to hydrogen energy conversion e?ciency. Torate and the solar to H 2 energy conversion e?ciency of high

  1. Chapter 3. Terms and Conditions of Employment RP-59 Self-Insurance shall promptly notify the University's Director of Risk Management

    E-Print Network [OSTI]

    Farritor, Shane

    the University's Director of Risk Management of: 1) any occurrence the commissioned law enforcement officer has Management to be effective. (c) The University's Director of Risk Management shall make a decision on any claim for benefits promptly, and not later than thirty (30) days after the Director of Risk Management

  2. Development of a Toolkit for Calculating Linear, Change-Point Linear and Multiple-Linear Inverse Building Energy Analysis Models, ASHRAE Research Project 1050-RP, Final Report 

    E-Print Network [OSTI]

    Kissock, J. K.; Haberl, J. S.; Claridge, D. E.

    2002-11-01

    This report summarizes the results of ASHRAE Research Project 1050: Development of a Toolkit for Calculating Linear, Change-Point Linear and Multiple Linear Inverse Building Energy Analysis Models. The Inverse Modeling ...

  3. NON-REFEREED PUBLICATIONS Dunn, M.A., R.P. Vlosky, and T.F. Shupe. 2005. Homebuilders attitudes and

    E-Print Network [OSTI]

    recomendaciones para su desarrollo." Revista Alternativas. Universidad Catolica de Santiago de Guayaquil, Ecuador fishing survey: the Red River. Louisiana Agricultural Experiment Station Research Summary 161. Baton Rouge

  4. UNL POLICY FOR DIVISION OF NET ROYALTY AND PROCEEDS Section 5 of the RP-4.4.2 Regents' Patent and Technology Transfer Policy includes

    E-Print Network [OSTI]

    Farritor, Shane

    and Technology Transfer Policy includes information on the division of net royalties and proceeds: "With respect intellectual property protection, and licensing or other technology transfer activity, including legal expenses licenses or other technology transfer activities related to an invention, or patent or other intellectual

  5. A Positive Feedback Synapse from Retinal Horizontal Cells to Cone Photoreceptors

    E-Print Network [OSTI]

    Alford, Simon

    an inhibitory synapse. Here we report that HCs also transmit to cone terminals a positive feedback signal cell; IPL, inner plexiform layer; mEPSC, miniature excitatory postsynaptic current; NO, nitric oxide

  6. Order Preserving and Shape Prior Constrained Intra-Retinal Layer Segmentation in Optical

    E-Print Network [OSTI]

    Heermann, Dieter W.

    the dataset we used for evaluation and reports empirical results. We conclude in Sect. 5. Fig. 1. An OCT B are: nerve fiber layer (NFL), ganglion cell layer and inner plexiform layer (GCL + IPL), inner nuclear

  7. Numerical simulation of the photoisomerization of retinal from the cis to the trans form 

    E-Print Network [OSTI]

    Sinha, Indrani

    2009-05-15

    systems including ethylene, 2-butene, and stilbene. The cis-trans isomerization is modeled and in each case the results agree well with those obtained from other computational and empirical methods. Next, we use the tight-binding model to simulate...

  8. Characterization of RPGR Variants and Their Role in Inherited Retinal Degeneration 

    E-Print Network [OSTI]

    Wright, Rachel

    2012-10-19

    about the physiological significance of expressing two distinct groups of variants. This study compares Rpgr^ex1-19 and Rpgr^ORF15 expression in developing photoreceptors using immunoblot analysis and immunohistochemistry, assesses ciliary affinity...

  9. Theoretical Analysis of a Spectrophotometric Technique for Measuring Oxygen Saturation in Retinal Vessels

    E-Print Network [OSTI]

    van Vliet, Lucas J.

    Vessels M. Üzümcü1 , F.M. Vos1 , A.M. Vossepoel1 , G.L. van der Heijde2 1. Pattern Recognition Group], the formation of pathological new vessels [2]. Such new vessels block sensitive areas of the retina and can a fluorescent dye is injected in the patient, which spreads all over the body through the blood vessels. Upon

  10. 2001 Special issue ONOFF retinal ganglion cells temporally encode OFF/ON sequence

    E-Print Network [OSTI]

    Uchiyama, Hiroyuki

    ; Innisfree, UK). A light-emitting diode (LED; lp 590 nm) was positioned in the center of the receptive ®elds

  11. The light-activated signaling pathway in SCN-projecting rat retinal ganglion cells

    E-Print Network [OSTI]

    Newman, Eric A.

    candidate channels, cyclic nucleotide-gated (CNG) channels and transient receptor potential (TRP) channels nucleotides modulate the signaling pathway, CNG channels do not appear to conduct the light-activated current the light response, (ii) CNG channel blockers fail to inhibit the light response, (iii) the effects

  12. Central retinal thickness is positively correlated with macular pigment optical density

    E-Print Network [OSTI]

    of healthy subjects. We report that macular pigment optical density (MPOD) has a significant and positive of the observed relationship (rw0.30) was independent of the technique used to measure MPOD, whether

  13. Patterned electrical stimulation of primate retina for the development of retinal prostheses

    E-Print Network [OSTI]

    Jepson, Lauren Hruby

    2012-01-01

    239–248. [16] Hottowy, P. , Beggs, J. , Chichilnisky, E. ,3311–3327. [25] Hottowy, P. , Beggs, J. , Chichilnisky, E. ,14:5–13. [8] Hottowy, P. , Beggs, J. , Chichilnisky, E. ,

  14. Molecular Evolution of Adeno-associated Virus for Improved Retinal Gene Therapies

    E-Print Network [OSTI]

    Klimczak, Ryan Raymond

    2010-01-01

    J, Humayun MS (2009) Artificial vision: needs, functioning,for the artificial restoration of vision in ONL-depleted

  15. Patterned electrical stimulation of primate retina for the development of retinal prostheses

    E-Print Network [OSTI]

    Jepson, Lauren Hruby

    2012-01-01

    electrode device for artificial vision in rabbits. Journalhigh resolution artificial vision to the blind. However, theof mediating advanced artificial vision. We probed the

  16. Patterned electrical stimulation of primate retina for the development of retinal prostheses

    E-Print Network [OSTI]

    Jepson, Lauren Hruby

    2012-01-01

    2.2.2 Electrical stimulation . . . . . . . . . . . . . . . .3.2.2 Electrical stimulation and recording . . . . . . . .Electrical stimulation of parallel pathways in the primate

  17. Ciliopathies : molecular and genetic basis for Ahi1 function in retinal degeneration

    E-Print Network [OSTI]

    Louie, Carrie MC

    2010-01-01

    to classic JS. Ahi1 and oncogenesis Though the Ahi1 locus indirectly contributes to oncogenesis. Jiang et. al. foundhas been associated with oncogenesis in specific forms of

  18. Molecular mechanisms mediating retinal reactive gliosis following bone marrow mesenchymal stem cell (BM-MSC) transplantation

    E-Print Network [OSTI]

    Tassoni, Alessia; Gutteridge, Alex; Barber, Amanda C.; Osborne, Andrew; Martin, Keith R.

    2015-01-01

    suspension by 7 minute incubation in 0.1% trypsin (Sigma-Aldrich, Corp. UK) at 37°C. DNase 0.01% (D5025-15 ku, Sigma-Aldrich, Corp. UK) was added to the sample followed by centrifugation at 600g for 5 minutes. The pellet was re-suspended in Mg2+/Ca2+ free...

  19. Modeling, Pattern Analysis and Feature-Based Retrieval on Retinal Images 

    E-Print Network [OSTI]

    Ying, Huajun

    2012-07-16

    . In this dissertation, I propose an analytical framework for the modeling of retina blood vessels to capture their statistical properties, so that based on these properties one can develop blood vessel mapping algorithms with self-optimized parameters. Then, other...

  20. Transcriptomic Analysis of Human Retinal Detachment Reveals Both Inflammatory Response and Photoreceptor

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , De´partement d'Ophtalmologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France, 5 management remains to this day exclusively surgical. We have used surgical specimens to perform

  1. Retinal Ligand Mobility Explains Internal Hydration and Reconciles Active Rhodopsin Structures

    E-Print Network [OSTI]

    *W Web-Enhanced Feature *S Supporting Information ABSTRACT: Rhodopsin, the mammalian dim resonance spectroscopy, to understand the transition between the dark and metarhodopsin I (Meta I) states to take on alternate stable conformations when bound to the receptor. In the dark state of rhodopsin, 11

  2. Nonlinear Optical Effects on Retinal Damage Thresholds in the 1200-1400 nm Wavelength Range 

    E-Print Network [OSTI]

    Echeverria, Francesco Jozac

    2015-05-12

    Recent changes in the maximum permissible exposure (MPE) limits for near-infrared (NIR) laser exposures are analyzed in light of nonlinear optical phenomena. We have evaluated the thresholds for supercontinuum (SC) generation ...

  3. Enhanced visualization of retinal pathologies with ultrahigh resolution optical coherence tomography

    E-Print Network [OSTI]

    Ko, Tony Hong-Tyng, 1975-

    2005-01-01

    Current clinical practice calls for the development of techniques to diagnose diseases in its early stages, when treatment is most effective and significant irreversible damage can either be prevented or delayed. Optical ...

  4. Effects of glial cell line-derived neurotrophic factor on cultured murine retinal progenitor cells

    E-Print Network [OSTI]

    Wang, Jinmei; Yang, Jing; Gu, Ping; Klassen, Henry

    2010-01-01

    of glial cell line-derived neurotrophic factor (GDNF)F. GDNF: a glial cell line-derived neurotrophic factor forlevel glial cell line-derived neurotrophic factor delivery

  5. Method for Confidence Metric in Optic Disk Location in Retinal Images -

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines light on dark matter ByMentor-ProtegeFromGasInnovation PortalEnergy

  6. a 3.37 mm length b 3.32 mm diameter

    E-Print Network [OSTI]

    Marc, Robert E.

    5.2 ml retinal subtense 300 µm/deg retinal arc 51 mm retinal area* 1024 ± 184 mm2 total.3 µl retinal subtense 31 µm/deg retinal arc 4.9 mm retinal area 15.6 mm2 cone:rod ratio 0/deg retinal arc 10.6 mm retinal area 52 mm2 cone:rod ratio mean cone density* mm-2 mean rod

  7. The ON-OFF dichotomy in visual processing: From receptors to perception

    E-Print Network [OSTI]

    Westheimer, Gerald

    2007-01-01

    leave a survey of retinal processing, however brief andsegregation of processing within the retinal ON and OFF

  8. Roles for Wnts and their receptors in topographic mapping and laminar termination

    E-Print Network [OSTI]

    Richman, Alisha

    2011-01-01

    information. Processing of Z-stack images from retinal andfor later image processing. Chick retinal explant culture

  9. Attention and the Indeterminacy of Visual Experience

    E-Print Network [OSTI]

    Stazicker, James David

    2011-01-01

    Early in post-retinal visual processing, information aboutEarly in post-retinal visual processing, information about

  10. Is sleep's 'supreme mystery' unraveling? An evolutionary analysis of sleep encounters no mystery; nor does life's earliest sleep, recently discovered in jellyfish.

    E-Print Network [OSTI]

    Kavanau, Julian L.

    2006-01-01

    degree of complex retinal processing occurs (see [3]) thein the sense of forming and processing a retinal image [18],

  11. Characterization of the Structure and Function of the Normal Human Fovea Using Adaptive Optics Scanning Laser Ophthalmoscopy

    E-Print Network [OSTI]

    Putnam, Nicole Marie

    2012-01-01

    motion processing using high-resolution retinal imaging.in visual processing: one that they maintain retinal image

  12. Resource-Bounded Strong Dimension versus Resource-Bounded Category

    E-Print Network [OSTI]

    Aduri, Pavan

    () | is a constructor}. Then R(all) = C, R(p) = E, R(p2 ) = EXP, R(pspace) = ESPACE, and R(comp) = DEC. Each resource

  13. LEARNING NON-HOMOGENOUS TEXTURES AND THE UNLEARNING PROBLEM WITH APPLICATION TO DRUSEN DETECTION IN RETINAL IMAGES

    E-Print Network [OSTI]

    mimics the human behavior of selective learning in the sense of fast memory renewal. We perform. If new knowledge is available batch learning algorithms have to be retrained. To ideally adapt

  14. Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes

    E-Print Network [OSTI]

    Gelfand, JM; Goodin, DS; Boscardin, WJ; Nolan, R; Cuneo, A; Green, AJ

    2012-01-01

    disease subtype in multiple sclerosis. Neurology 69: 2085–layer atrophy between multiple sclerosis subtypes. J Neurolnerve fiber layer in multiple sclerosis. High resolution

  15. Performance of photovoltaic arrays in-vivo and characteristics of prosthetic vision in animals with retinal degeneration

    E-Print Network [OSTI]

    Palanker, Daniel

    Performance of photovoltaic arrays in-vivo and characteristics of prosthetic vision in animals neurons. Subretinal photovoltaic arrays convert pulsed illumination into pulsed electric current

  16. 2-ethylpyridine, a cigarette smoke component, causes mitochondrial damage in human retinal pigment epithelial cells in vitro

    E-Print Network [OSTI]

    Kenney, MC; Mansoor, S; Gupta, N; Falatoonzadeh, P; Kuppermann, BD

    2014-01-01

    a cigarette smoke component, causes mitochondrial damage ina cigarette smoke component, causes mitochondrial damage ina cigarette smoke component, causes mitochondrial damage in

  17. Color vision is achieved by comparing the inputs from retinal photoreceptor neurons that differ in their wavelength

    E-Print Network [OSTI]

    Desplan, Claude

    objects lacks UV and is composed pre- dominantly of green/yellow middle-energy wavelengths. Therefore green-light-sensitive cone R photoreceptor cell Rh rhodopsin Rh1 blue/green-sensitive opsin S cone blue to UV and green wavelengths [1]. This two-pigment system may have evolved into a broader range

  18. Experimentally Induced Retinal Projections to the Ferret Auditory Thalamus: Development of Clustered Eye-Specific Patterns in a

    E-Print Network [OSTI]

    Sur, Mriganka

    and cellular differentiation. Key words: retinogeniculate; eye-specific segregation; chol- era toxin subunit B; medial geniculate nucleus; afferents; cross- modal plasticity A fundamental feature of the development

  19. Detecting pairwise correlations in spike trains: an objective comparison of methods and application to the study of retinal waves

    E-Print Network [OSTI]

    Cutts, Catherine S.; Eglen, Stephen J.

    2014-10-22

    Correlations in neuronal spike times are thought to be key to processing in many neural systems. Many measures have been proposed to summarize these correlations and of these the correlation index is widely used and is the standard in studies...

  20. Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice

    E-Print Network [OSTI]

    2011-01-01

    the phenomenon of HESC-derived RPE: anatomy of cell genesis,population of donor-derived photoreceptor cells (indicatedof human embryonic stem cell-derived photoreceptors restores

  1. Upper left: visual perception with a 32 x 32 electrode array retinal implant. Upper right: visual perception with a 64 x 64 electrode array retinal implant. Lower left: visual perception with a 32 x 32 electrode array retinal implant with blur. Lower righ

    E-Print Network [OSTI]

    Haile, Sossina M.

    of research is astonishing, and embraces phenomena from genomics to computational finance, alongside

  2. Effects of non-linear processing on information transfer in the lateral geniculate nucleus

    E-Print Network [OSTI]

    Denning, Kate

    2006-01-01

    1997) Adaptation of retinal processing to image contrast and1997) Adaptation of retinal processing to image contrast andProcessing Systems 14:269-276. Shapley R (1997) Retinal

  3. The Limits of Visual Resolution

    E-Print Network [OSTI]

    Rossi, Ethan Andrew

    2009-01-01

    the first stages of retinal processing is remarkable. 4.5.2stages of neural processing; this retinal circuitry changesresolution. 5.3.8 Post-Processing of Retinal Imagery Digital

  4. Open Journal of Molecular and Integrative Physiology, 2012, 2, 75-86 OJMIP doi:10.4236/ojmip.2012.23011 Published Online August 2012 (http://www.SciRP.org/journal/ojmip/)

    E-Print Network [OSTI]

    Cooper, Robin L.

    environmental temperature changes will impact sur- vival and in time the distribution of a species. The sig temperature on survival, heart rate and neural function in crayfish (Procambarus clarkii) and prawn (Macrobrachium rosenbergii) species Yoo Sun Chung, Richard M. Cooper, Justin Graff, Robin L. Cooper* Department

  5. Open Journal of Fluid Dynamics, 2012, 2, 35-43 doi:10.4236/ojfd.2012.22004 Published Online June 2012 (http://www.SciRP.org/journal/ojfd)

    E-Print Network [OSTI]

    Apte, Sourabh V.

    Open Journal of Fluid Dynamics, 2012, 2, 35-43 doi:10.4236/ojfd.2012.22004 Published Online June; accepted May 25, 2012 ABSTRACT In many applications, a moving fluid carries a suspension of droplets of a second phase which may change in size due to evaporation or condensation. Examples include liquid fuel

  6. Journal of Geographic Information System, 2011, 3, 334-344 doi:10.4236/jgis.2011.34031 Published Online October 2011 (http://www.SciRP.org/journal/jgis)

    E-Print Network [OSTI]

    Mountrakis, Giorgos

    , and diverse sensor feeds. These datasets are col- lected, stored, and distributed by a variety of federal (e.g. Ushahidi) or even individuals. Through advancements in sensor technology, computer hardware, and software (IR), geospa- tial datasets are indexed with metadata describing their essential properties (e.g. date

  7. Journal of Environmental Protection, 2012, 3, 1117-1123 doi:10.4236/jep.2012.329130 Published Online September 2012 (http://www.SciRP.org/journal/jep)

    E-Print Network [OSTI]

    Lin, C.-Y. Cynthia

    in Lin (2010), in which I use spatial econometrics to analyze air pollution externalities. In Lin (2010,6]. A secondary pollutant, ozone is not emitted directly but is formed in ambient air by chemical reactions in Econometrics to Measure Ozone Pollution Externalities C.-Y. Cynthia Lin Agricultural and Resource Economics

  8. 3-D INTEGRATION USING WAFER BONDING J.-Q. L *, A. KUMAR *, Y. KWON *, E.T. EISENBRAUN **, R.P. KRAFT *, J.F. McDONALD *, R.J.

    E-Print Network [OSTI]

    Lü, James Jian-Qiang

    . McDonald et al. studied via holes formed by laser drilling, etching, Cu sputtering, and Au plating unattractive. Conventional scaling of planar ICs has advanced significantly in the last decade, partially generations of conventional scaling of planar ICs [5]. However, this scaling process has begun to encounter

  9. Cameron, R.P., Barnett, S.M., and Yao, A.M. (2014) Optical helicity of interfering waves. Journal of Modern Optics, 61 (1). pp. 25-31. ISSN 0950-

    E-Print Network [OSTI]

    2014-01-01

    the fundamental description of the angular momentum of light in electromagnetic theory has proved surprisingly taken by the helicity of light within classical electromagnetic theory and reflect upon some of its with the `orbital' angular momentum that is associated with the spatial distri- bution of the electromagnetic field

  10. Dziak, R.P., D.R. Bohnenstiehl, and D.K. Smith. 2012. Hydroacoustic monitoring of oceanic spreading centers: Past, present, and future. Oceanography 25(1):116127,

    E-Print Network [OSTI]

    Bohnenstiehl, Delwayne

    of The Oceanography Society. Send all correspondence to: info@tos.org or The Oceanography Society, PO Box 1931 characteristics and because they are the loudest natural sounds recorded in the ocean. Because of the combined, Cooperative Institute for Marine Resources Studies/Oregon State University, Hatfield Marine Science Center

  11. Specifying and controlling the optical image on the human retina.

    E-Print Network [OSTI]

    Westheimer, Gerald

    2006-01-01

    tions, intra-retinal light processing cannot be excluded asretinal and higher neural stages in the processing of aand retinal summation in analyzing visual processing became

  12. Automatic Microaneurysm Detection and Characterization Through Digital Color Fundus Images

    E-Print Network [OSTI]

    Martins, Charles

    2010-01-01

    retinal images. International Conference on Image Processing,retinal angiograms of diabetic patients. In International Conference on Image Analysis and Processing (

  13. The development of direction selectivity in the mouse retina

    E-Print Network [OSTI]

    Elstrott, Justin Blake

    2009-01-01

    at each stage of visual processing- retinal, subcortical andvisual processing stream is combined with other retinalof visual processing. On-Off direction selective retinal

  14. Symmetry in the retinogeniculate motion circuit /

    E-Print Network [OSTI]

    Kaye, Alfred

    2013-01-01

    cortical stages of processing, retinal direction selectivityfeatures of retinal mo- tion processing with the efficientretinal ganglion cell subtypes and brain structures involved in motion processing.

  15. Imaging the foveal cone mosaic with a MEMS-based adaptive optics scanning laser ophthalmoscope

    E-Print Network [OSTI]

    Li, Yiang

    2010-01-01

    4.2.1 Retinal imaging 4.2.2 Image processing and analysisprocessing, control theory and optics all applied toward advancing adaptive optics for retinal

  16. Carbon Based Nano-Materials Research, Development and Applications in Optoelectronics

    E-Print Network [OSTI]

    Wang, Feihu

    2012-01-01

    RP Relative Purity PEMFC Proton Exchange Membrane Fuel Cellexchange membrane fuel cell (PEMFC) utilizing hydrogen as

  17. Predator satiation Periodical Cicadas in Ohio

    E-Print Network [OSTI]

    Mitchell, Randall J.

    ­ = Transmission coefficient (affected by ( y contagiousness and host behavior) · Rp = LS This is a molecular

  18. Biochem. J. (2011) 435, 116 (Printed in Great Britain) doi:10.1042/BJ20100965 1 REVIEW ARTICLE

    E-Print Network [OSTI]

    Craik, Charles S.

    2011-01-01

    , digestive disorders, inflammation, cystic fibrosis, retinal disorders, psoriasis and other diseases

  19. A Songbird Model of Genetically Based Speech Disorders

    E-Print Network [OSTI]

    Condro, Michael Christopher

    2013-01-01

    processing pathways for rotational and expansion visual stimuli. Summary Fruit flies respond to panoramic retinal

  20. Many of the behaviors exhibited by flying insects are mediated visually. For example, insects rely on complex visual

    E-Print Network [OSTI]

    Daniel, Tom

    on complex visual processing (i) to maintain their orientation with respect to the retinal panorama (Collett

  1. A. Heyden et al. (Eds.): ECCV 2002, LNCS 2353, pp. 502516, 2002. Springer-Verlag Berlin Heidelberg 2002

    E-Print Network [OSTI]

    Mirmehdi, Majid

    - processing step, the colour retinal image is segmented using Fuzzy C-Means clustering. We then classify localisation in retinal image analysis is of critical importance, the segmentation process provides us.K. markham@gifford.co.uk Abstract. Retinal exudates are a characteristic feature of many retinal diseases

  2. Engineered Adeno-Associated Viral Vectors for Gene Therapy in the Retina

    E-Print Network [OSTI]

    Byrne, Leah

    2011-01-01

    processing visual information through phototransduction. The overwhelming majority of inherited retinal

  3. Biosynthesis of all-trans-Retinoic Acid and Regulation of Retinoids Homeostasis in Primary Hippocampal Astrocytes and Neurons

    E-Print Network [OSTI]

    Wang, Chao

    2010-01-01

    and processing retinol .. 5 ADHs .6 SDRs ..7 Retinalprocessing can be an evolutionary conserved process. Retinal

  4. Repetition Suppression Dissociates Spatial Frames of Reference4 in Human Saccade Generation5

    E-Print Network [OSTI]

    Diedrichsen, Jörn

    of the sensorimotor transformation for a saccade,41 including sensory processing, saccade planning and saccade execution. We42 distinguished between retinal (eye-centered) and non-retinal (e.g., head-43 centered) coding factorial design with factors retinal and non-retinal coordinates48 and levels novel and repeated. In all

  5. www.ann-phys.org Synergetic analysis of the Haussler-von der Malsburg equations

    E-Print Network [OSTI]

    Pelster, Axel

    in processing optical information. In the adult animal, however, neighboring retinal cells project onto

  6. Corner detection in color images by multiscale combination of end-stopped cortical cells

    E-Print Network [OSTI]

    Würtz, Rolf P.

    processing: Retinal cells feed their output to the LGN, whose output is combined to form orientation

  7. Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second

    E-Print Network [OSTI]

    Potsaid, Benjamin M.

    We demonstrate ultrahigh speed swept source/Fourier domain ophthalmic OCT imaging using a short cavity swept laser at 100,000 – 400,000 axial scan rates. Several design configurations illustrate tradeoffs in imaging speed, ...

  8. Changing dynamics of spontaneous waves during retinal development: a novel panretinal perspective achieved with the Active Pixel Sensor (APS) 4,096 electrodes array 

    E-Print Network [OSTI]

    Hennig, Matthias; Sernagor, Evelyne; Maccione, Alessandro; Gandolfo, Mauro; Eglen, Stephen; Berdondini, Luca

    2010-07-02

    The developing retina exhibits spontaneous waves of activity spreading across the ganglion cell layer. These waves are present only during a limited perinatal period, and they are known to play important roles during the ...

  9. Evidence of Retinal Light Damage in Rana cascadae: A Declining Amphibian Species Author(s): Katherine V. Fite, Andrew Blaustein, Lynn Bengston and Heather E. Hewitt

    E-Print Network [OSTI]

    Blaustein, Andrew R.

    , and build upon a wide range of content in a trusted digital archive. We use information technology and tools. To assesswhetherthe retinasof this species maybe showingsignsof injury resultingfrom cumulativeexposure to solar, pathogens, overcollection, natural popu- lation fluctuations, and increased solar ultravi- olet radiation

  10. Dependence of Retinal Ganglion Cells' Responses to Natural Images on the Mean Contrasts of the Receptive-Field Center and Surround

    E-Print Network [OSTI]

    Grzywacz, Norberto

    of information (Laughlin, 1981), help constrain energy consumption (Vincent & Baddeley, 2003), or reduce, 1953; Kuffler, 1953; Rodieck, 1965; Levick, 1967; Enroth-Cugell & Lennie, 1975; Amthor et al., 1989 in all invertebrate and vertebrate species studied (Rattliff, 1965; Sagdullaev & McCall, 2005). Several

  11. Studies of meutron star X-ray binaries

    E-Print Network [OSTI]

    Thompson, Thomas W. J.

    2008-01-01

    while the energy released through thermonuclear fusion isthermonuclear ignition the hydrogen burns via the rapid-proton (rp) process where energythermonuclear ignition the hydrogen burns via the rapid-proton (rp) process where energy

  12. Muscular Responses and Movement Strategies During Stumbling Over Obstacles

    E-Print Network [OSTI]

    -dependent response modulation. Both strategies had the same initial electromyographic responses till 100 ms (RP1-RP2 of sensory afferents. The electromyographic (EMG) responses in leg muscles occurring after stimulation

  13. Supporting Information The effect of strong acid functional groups on electrode rise potential in

    E-Print Network [OSTI]

    ElectrodePotential(vsAgAgCl-1 ) YP50(Neg) YP(Pos) RP20(Neg) RP20(Pos) SX+(Neg) SX+(Pos) BC(Neg) BC(Pos) Hrd(Neg) Hrd(Pos) Figure

  14. Organic synthesis as an effective approach to chemical, pharmaceutical, and biosynthetic investigations of natural products

    E-Print Network [OSTI]

    Suyama, Takashi L.

    2009-01-01

    mm Synergi 4? Hydro- RP 80A column, MeCN/H 2 O gradient) tousing a Synergi 4? Hydro-RP 80A (250 x 10 mm) column (1.2

  15. A simple method for enzymatic synthesis of unlabeled and radiolabeled Hydroxycinnamate-CoA

    E-Print Network [OSTI]

    Rautergarten, Carsten

    2012-01-01

    column (Synergy 4u Fusion-RP 80A 250× 2.0 mm, Phenomenex,column (Synergy 4u Fusion-RP 80A 250× 10.0 mm, Phenomenex)

  16. A Simple Method for Enzymatic Synthesis of Unlabeled and Radiolabeled Hydroxycinnamate-CoA

    E-Print Network [OSTI]

    Rautengarten, Carsten; Baidoo, Edward; Keasling, Jay D.; Scheller, Henrik Vibe

    2010-01-01

    column (Synergy 4u Fusion-RP 80A 250× 2.0 mm, Phenomenex,column (Synergy 4u Fusion-RP 80A 250× 10.0 mm, Phenomenex)

  17. Multi-core beamformer for spatio-temporal MEG source activity reconstruction

    E-Print Network [OSTI]

    Diwakar, Mithun

    2011-01-01

    NeuroImage 25, 734-745. Marinkovic, K. , Dhond, R.P. , Dale,NeuroImage 25, 734- 745. Marinkovic, K. , Dhond, R.P. ,Dale and Halgren, 2001; Marinkovic et al. , 2003). The L1-

  18. New Challenges in Contamination Control: The Leadership Role of IEST in Shaping Future Research and Practices.

    E-Print Network [OSTI]

    Xu, Tengfang; Eudy, Jane; Berndt, Charles

    2007-01-01

    The RP specifies four outgassing temperatures viz. , 50 °C (as they pertain to outgassing and endurance of flexible

  19. Scottish Universities Physics Alliance Peer Reviewed Publications

    E-Print Network [OSTI]

    Strathclyde, University of

    for nickel-titanium alloy Swift, DC; Niemczura, JG; Paisley, DL; Johnson, RP; Hauer, A; Hackenberg, RE

  20. Association Analysis of the Extended MHC Region in Celiac Disease Implicates Multiple Independent Susceptibility Loci

    E-Print Network [OSTI]

    2012-01-01

    Symposium on Coeliac Disease. Tampere, Finland: Institute ofTechnology, University of Tampere. pp 265–274. 25. Hall RP,

  1. IAIFORIUA'IW3NPWCE!SSiNG LET MRS l(l971) 6%68.NORTH-HOLLAND PUBLISHING CY)@ANY Ret&ted 30 April 19' i

    E-Print Network [OSTI]

    Borodin, Allan

    (rP~). Thereffxe, an nth . c . polynomsal can be evaluated at fi porn;;; 141) operations,andatn pointsin

  2. Resultatives as Causal Relations between Events Ik-Hwan Lee

    E-Print Network [OSTI]

    . She washes them clean. (resultative) = She washes them and, because she washes them, they become clean painted the car a pale shade of red. (RP=Noun Phrase) [Object-predicated] c. The brook froze solid. (RP of red, is predicated of the direct object NP the car. In (3c) the RP solid is predicated of the surface

  3. Design and syntheses of nonnatural amino acids and their incorporation into somatostatin and RGD analogs

    E-Print Network [OSTI]

    Kelleman, Audrey

    2007-01-01

    589 nm); Analytical RP-HPLC: 80A:20B 10A:90B / 30 min. r t =589 nm); Analytical RP-HPLC: 80A:20B D 10A:90B / 30 min. r t589 nm); Analytical RP-HPLC: 80A:20B D 10A:90B / 30 min. r t

  4. Office of External Affairs and Communications

    E-Print Network [OSTI]

    1RP Tel: 01223 765490 Email: penny.wilson@admin.cam.ac.uk Web: www 1RP Tel: 01223 765490 Email: penny.wilson@admin.cam.ac.uk Web: www.cam.ac.uk/communityaffairs Staff, Cambridge CB2 1RP Tel: 01223 765490 Email: penny.wilson@admin.cam.ac.uk Web: www

  5. Molecular Biology and Analytical Chemistry Methods Used to Probe the Retinoid Cycle

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    reformation of 11-cis-retinal from all-trans-retinal by several chemical transformations. The classical vision. In many cases, the disease is caused by loss of catalytic or retinoid-binding function (2, 4, 5

  6. A Feature-Based, Robust, Hierarchical Algorithm for Registering Pairs of Images

    E-Print Network [OSTI]

    Radke, Rich

    overlaps compare favorably with retinal image registration techniques published in the literature. Index TermsÐRobust estimation, registration, transformation estimation, image mosaic, retinal imaging, feature extraction, feature refinement, multiscale methods, ophthalmic image processing, biomedical image processing

  7. EVALUATION AND BENCHMARK FOR BIOLOGICAL IMAGE SEGMENTATION Elisa Drelie Gelasca, Jiyun Byun, Boguslaw Obara, B.S. Manjunath

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    value to the image processing re- searchers is that the data comes with associated ground truth in evaluating and benchmarking new technologies. This is par- ticularly important in image processing methods) (Retinal layers Microtubule tracing Cell segmentation Retinal layer

  8. Activation of the retina's regenerative potential by embryonic stem cell-derived microvesicles

    E-Print Network [OSTI]

    Katsman, Diana

    2012-01-01

    software for image processing. In BrdU-retinal marker co-and processing of the Z-stacked images. Electroretinography: Bilateral ERGs were recorded to assess the baseline retinal

  9. Photochemical restoration of visual responses in blind mice

    E-Print Network [OSTI]

    Polosukhina, Aleksandra

    2013-01-01

    retinal cells allows for direct stimulation of surviving neurons, potentially shaping a clearer neu- ral/processing

  10. 25:8-15, 2010. doi:10.1152/physiol.00038.2009Physiology Brian M. Kevany and Krzysztof Palczewski

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    for the regeneration of 11-cis-retinal in a process referred to as the "visual cycle" (78, 83). Upon absorption photoreceptor cells, responsible for collecting and processing visual stimuli, and the retinal pigment Medicine .. Retinal Pigment Epithelium Physiology .. Photoreception Physiology .. Phagocytosis Physiology

  11. Universitat des Saarlandes Fachrichtung 6.1 Mathematik

    E-Print Network [OSTI]

    to analyse dig- ital databases of retinal images in a short time, and to process the image in situ while to have an efficient image processing system for the analysis of huge databases of retinal images Preprint Nr. 320 Fast Retinal Vessel Analysis Michael Krause, Ralph Maria Alles, Bernhard Burgeth

  12. A Neural Computation for Visual Acuity in the Presence of Eye Movements

    E-Print Network [OSTI]

    the complex eye movement trajectory, then it could realign the retinal responses before processing them must identify the retinal firing patterns induced by the stimulus while discounting similar patterns caused by spontaneous retinal activity. This is a challenge since the trajectory of the eye movements

  13. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 54, NO. 6, JUNE 2007 993 Image Processing for a High-Resolution

    E-Print Network [OSTI]

    Palanker, Daniel

    system. Index Terms--Biomedical image processing, macular degenera- tion, retinal prosthesis, retinitisIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 54, NO. 6, JUNE 2007 993 Image Processing for a High-Resolution Optoelectronic Retinal Prosthesis Alon Asher*, William A. Segal, Stephen A. Baccus

  14. Research Article Visual Control of Action Without

    E-Print Network [OSTI]

    Loomis, Jack M.

    almost always entails retinal flow, research on the physiology of optic-flow processing has invari- ablyResearch Article Visual Control of Action Without Retinal Optic Flow Jack M. Loomis,1 Andrew C a field of obstacles and catching a ball, entails retinal flow with motion energy (first-order motion). We

  15. A vacancy is available for a motivated PhD student

    E-Print Network [OSTI]

    Mouritsen, Henrik

    on diverse aspects of retinal processing. For example, we are interested in the cellular distribution are interested in retinal processing, and if you are highly motivated to learn and to employ different methods Forschergruppe Dynamics and Stability of Retinal Processing and the EU project RETICIRC. Thus, you will become

  16. Retina Encoder Tuning and Data Encryption for Learning Retina Implants Oliver Baruth, Rolf Eckmiller, and Dirk Neumann

    E-Print Network [OSTI]

    Behnke, Sven

    time as specified by a physiological-inspired model [6-8] of retinal informa- tion processing be tuned continuously within a wide range to mimic the typical information processing of primate retinal with retinal degen- erative disorders was implemented by an array of 256 tunable spatio-temporal filters (ST

  17. revised for resubmission to IEEE Trans. on Pattern Analysis and Machine Intelligence Frame-Rate Spatial Referencing Based on Invariant

    E-Print Network [OSTI]

    Radke, Rich

    indexing, robust estimation, retinal imaging, ophthalmic image processing, biomedical image processing-Rate Spatial Referencing Based on Invariant Indexing and Alignment with Application to On-Line Retinal Image registration error in either case is about 1 pixel. Index terms: retinal laser surgery, registration, invariant

  18. Int. Conf. Neural Inf. Proc., ICONIP '96, Hongkong, Sept. 1996 Concerning the development of retina implants with neural nets *

    E-Print Network [OSTI]

    Behnke, Sven

    implants for blind humans suffering from various retinal degenerative diseases to regain a moderate amount (RE) outside the eye has to replace the information processing of the retina. A retina stimulator (RS), implanted adjacent to the retinal ganglion cell layer at the retinal `output', has to contact a sufficient

  19. The Art and Science of Depiction Fredo Durand

    E-Print Network [OSTI]

    Durand, Frédo

    as information processing · Input: retinal image · Output: 3D layout, object recognition, etc. Retinal image Problems Intro to Visual Perception 2 Plan · Vision as an cognitive process · Computational theory stimulus: reality · Proximal stimulus: retinal image Distal stimulus (3D)proximal stimulus (2D) Intro

  20. Perceptual and Artistic Principles for Effective Computer Depiction

    E-Print Network [OSTI]

    Durand, Frédo

    ;19 Vision as information processing · Input: retinal image · Output: 3D layout, object recognition, etc. Retinal image Intermediate Data Scene understanding Processing Processing 20 Computational theory) · Contrast, edge detection · Not so easy Cup Raw edge detection Image- based processing Retinal Image 23

  1. Perceptual and Artistic Principles for Effective Computer Depiction

    E-Print Network [OSTI]

    Durand, Frédo

    theory of vision · Complex mapping #12;19 Vision as information processing · Input: retinal image Raw edge detection Image- based processing Retinal Image #12;23 Surface-based · Visible surfaces, organization · Distance, orientation Cup Local orientation Image- based processing Retinal Image Surface- based

  2. Color Perception and Applications Penny Rheingans

    E-Print Network [OSTI]

    Rheingans, Penny

    Vision Processing of visual stimuli by the human visual system begins in the eye and continues to the retinal ganglia cells. Retinal ganglia cells have concentric receptive fields with a center versa, though some cells respond to differences between blue and yellow light. In the retinal ganglia

  3. Miniature eye movements enhance fine spatial detail Michele Rucci1

    E-Print Network [OSTI]

    Rucci, Michele

    retinal image motion is eliminated in the laboratory5­9 . However, it has long been debated whether a new method of retinal image sta- bilization18 , we selectively eliminated the motion of the retinal to constitute an effective sampling strategy by which the visual system enhances the processing of spatial

  4. J Sign Process Syst DOI 10.1007/s11265-008-0217-3

    E-Print Network [OSTI]

    Stanchev, Peter

    J Sign Process Syst DOI 10.1007/s11265-008-0217-3 Retinal Vessel Radius Estimation and a Vessel of automatic tools [2]. One important task in the automated processing of retinal images is the segmentation Science + Business Media, LLC. Manufactured in The United States Abstract This paper studies the retinal

  5. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 54, NO. 12, DECEMBER 2007 2261 Tissue Damage by Pulsed Electrical Stimulation

    E-Print Network [OSTI]

    Palanker, Daniel

    of the retina degenerates, yet the inner retinal neurons, the "processing circuitry" downstream from in retinal ganglion cells occurred at pulse durations near chronaxie--around 1.3 ms. Index Terms--Electrical stimulation, electroporation, neural prosthesis, neural stimulation, retinal prosthesis. I. INTRODUCTION AGE

  6. Frame-Rate Spatial Referencing Based on Invariant Indexing and Alignment with Application to On-Line

    E-Print Network [OSTI]

    Radke, Rich

    , registration, invariant indexing, robust estimation, retinal imaging, ophthalmic image processing, biomedical-Line Retinal Image Registration #3; Hong Shen 1 Charles V. Stewart 1 Badrinath Roysam 1 Gang Lin 1 Howard L is achieved. The median registration error in either case is about 1 pixel. Index terms: retinal laser surgery

  7. An Image Analysis Framework for the Early Assessment of Hypertensive Retinopathy Signs

    E-Print Network [OSTI]

    Zabulis, Xenophon

    of the image processing, much effort has been devoted for segmenting the retinal vasculature and extracting its a framework for the detection and measurement of retinal vessels in fundoscopy images. The proposed method segments retinal vessels, enabling the actual measurement of the vessel diameter. A Graphical User

  8. The FASEB Journal Research Communication DICER1 is essential for survival of postmitotic rod

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    to combat blindness. Down-regula- tion of the microRNA (miRNA)-processing enzyme DICER1 in the retinal Photoreceptor cell death is the proximal cause of blindness in many retinal degenerative disor- ders; hence, another retinal cell type that is se- verely affected in AMD. Using a conditional-knockout (cKO) mouse

  9. ORIGINAL PAPER Stefan D. Wilke Andreas Thiel Christian W. Eurich

    E-Print Network [OSTI]

    Eurich, Christian

    the encoding of movement patterns on the retinal level is a prerequisite for the study of processing in later 1998). This period-doubling bi- furcation in retinal processing, which could be shown to be the cause (Pseudemys scripta elegans) retinal ganglion cells to dierent motion patterns. The onset of motion

  10. IOP PUBLISHING JOURNAL OF NEURAL ENGINEERING J. Neural Eng. 7 (2010) 016006 (10pp) doi:10.1088/1741-2560/7/1/016006

    E-Print Network [OSTI]

    Itti, Laurent

    2010-01-01

    .1088/1741-2560/7/1/016006 Saliency-based image processing for retinal prostheses N Parikh1, L Itti2 and J Weiland3 1 Department field of view. Retinal prosthesis research can involve image processing in a number of different ways implemented on a portable, wearable system can be used in conjunction with a retinal prosthesis, to identify

  11. DEVELOPMENT OF A NATURAL GAS SYSTEMS ANALYSIS MODEL (GSAM) VOLUME I - SUMMARY REPORT VOLUME II - USER'S GUIDE VOLUME IIIA - RP PROGRAMMER'S GUIDE VOLUME IIIB - SRPM PROGRAMMER'S GUIDE VOLUME IIIC - E&P PROGRAMMER'S GUIDE VOLUME IIID - D&I PROGRAMMER'S GUIDE

    SciTech Connect (OSTI)

    Unknown

    2001-02-01

    This report summarizes work completed on DOE Contract DE-AC21-92MC28138, Development of a Natural Gas Systems Analysis Model (GSAM). The products developed under this project directly support the National Energy Technology Laboratory (NETL) in carrying out its natural gas R&D mission. The objective of this research effort has been to create a comprehensive, non-proprietary, microcomputer model of the North American natural gas market. GSAM has been developed to explicitly evaluate components of the natural gas system, including the entire in-place gas resource base, exploration and development technologies, extraction technology and performance parameters, transportation and storage factors, and end-use demand issues. The system has been fully tested and calibrated and has been used for multiple natural gas metrics analyses at NETL in which metric associated with NETL natural gas upstream R&D technologies and strategies under the direction of NETL has been evaluated. NETL's Natural Gas Strategic Plan requires that R&D activities be evaluated for their ability to provide adequate supplies of reasonably priced natural gas. GSAM provides the capability to assess potential and on-going R&D projects using a full fuel cycle, cost-benefit approach. This method yields realistic, market-based assessments of benefits and costs of alternative or related technology advances. GSAM is capable of estimating both technical and commercial successes, quantifying the potential benefits to the market, as well as to other related research. GSAM, therefore, represents an integration of research activities and a method for planning and prioritizing efforts to maximize benefits and minimize costs. Without an analytical tool like GSAM, NETL natural gas upstream R&D activities cannot be appropriately ranked or focused on the most important aspects of natural gas extraction efforts or utilization considerations.

  12. IPSJ SIG Technical Report 1 1 1 1 1 1

    E-Print Network [OSTI]

    Kasahara, Hironori

    , , . , Web , . 2 . , . ( 1 ) Web Arduino (1 ), . ( 2 ) Arduino RP-X , Web . ( 3 ) Arduino HTML , . , , Web 9IPSJ SIG Technical Report RP-X 1 Web 1 1 1 1 1 1 Web , , , Web RP-X , QoS (Quality of Service) Web , Web Web , 1.04 . , , Web QoS(Quality of Service) , 1.66 . Web , . Realization of 1 Watt Web Service

  13. Supplementary Figure S1. Light-associated motor responses of worms expressing (b)opsin in neurons. a, Vigorously crawling TG animals pre-incubated with 10 M 9-cis-retinal and expressing

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    Supplementary Figure S1. Light-associated motor responses of worms expressing (b)opsin in neurons)opsin in neurons were exposed to blue light (488 ± 20 nm) for 1 s at indicated intensities and their motor responses to light were recorded and scored. Data represent three independent experiments with 3- 10 worms

  14. Energy Data Sourcebook for the U.S. Residential Sector

    E-Print Network [OSTI]

    Wenzel, T.P.

    2010-01-01

    Conditioning Equipment. Arthur D. Little Associates, Inc.Prepared for US DOE. Arthur D. Little 46230. November.Data, prepared for Arthur D. Little, Inc. EPRI project RP-

  15. Alternative Fuel Vehicles: The Case of Compressed Natural Gas (CNG) Vehicles in California Households

    E-Print Network [OSTI]

    Abbanat, Brian A.

    2001-01-01

    Infrastructure F. Current California CNG Vehicle UseCharacteristics of CNG Vehicles Review of Previous Studies/RP) Studies of AFVs/CNG Vehicles i. British Columbia, Canada

  16. Bike/ped bridge To Palo Alto

    E-Print Network [OSTI]

    Kay, Mark A.

    TECH R RP To MountainView San Antonio Shopping Center (Walmart,Kohl's, Target and more) SE W P To Menlo

  17. Effects of long-term flutamide treatment during development in zebra finches

    E-Print Network [OSTI]

    2007-01-01

    Term Flutamide 13 [7] M. Gahr, R. Metzdorf, The sexuallyR. Lohmann, R.P. Vloet, M. Gahr, Androgen receptors in the

  18. BEAM-CAVITY INTERACTION IN ELECTRON STORAGE RINGS

    E-Print Network [OSTI]

    Henkin, Bruce M.

    2008-01-01

    the values of R,p given in egs. (18) and (19). It may beautomatically satisfied, and egs. (30) and (34) are reduced

  19. Vessel network detection using contour evolution and color components

    E-Print Network [OSTI]

    Ushizima, Daniela

    2013-01-01

    segmentation of retinal blood vessels and identification ofnormalization and local vessel detection. IEEE Trans MedLea. A review of 3d vessel lumen segmentation techniques:

  20. Received 20 Oct 2012 | Accepted 29 Apr 2013 | Published 18 Jun 2013 Cortical responses elicited by photovoltaic

    E-Print Network [OSTI]

    Palanker, Daniel

    elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials Yossi developed a wireless photovoltaic retinal prosthesis, in which camera- captured images are projected onto

  1. Technische Universitat Bernstein Center for Berlin Computational Neuroscience

    E-Print Network [OSTI]

    Wiskott, Laurenz

    's Thesis Self-organization Of V1 Complex-Cells Based On Slow Feature Analysis And Retinal Waves Sven D¨ahne

  2. Robust Biological Image Sequence Analysis Using Graph Based Approaches

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    informatics refers to managing, processing, analysing, annotating, navigating and understanding biological microscopy from Williams Lab at UCLA [2]. Melanosomes are organelles present in the retinal pigment

  3. List of Publications of Professor Ramanath Cowsik 1. Neutral Pion Production by 17 GeV Negative Pions in Carbon.

    E-Print Network [OSTI]

    of Primary Helium Nuclei by a Magnetic Spectrograph. R. Cowsik, Y. Pal, S.N. Tandon and R.P. Verma, Can. J of Cosmic Ray Helium Nuclei with Magnetic Spectrograph. R. Cowsik, Y. Pal, S.N. Tandon and R.P. Verma, ibid (1970);11th International Cosmic Ray Conference, Budapest. 23. Solar Flares, the Lunar Surface, and Gas

  4. Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent

    E-Print Network [OSTI]

    Butler, Samantha

    Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent Regulates, Toronto, Ontario, Canada M5G 1X8 Commissural spinal axons extend away from the roof plate (RP) in response to the dorsal midline and are generated by the bone morphogenetic proteins (BMPs) in the roof plate (RP) (Liem

  5. Ultrasound in Med. & Bidl. Vol. 8. pp. 207-208 Printed in Great Britain. All rights reserved

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    . Ultrasound Med. Biol. 7:267-273. Liburdy, R.P. (1979). Radiofrequency radiation alters the immune system. Res. 77~34-46. Liburdy, R.P. (1980). Radiofrequency radiation alters the immune system. II. Modulation exper- imental groups: one group received radiofrequency radiation (RFR) on a single occasion

  6. Fast decomposition of p-groups in the Roquette category, for p > 2

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Fast decomposition of p-groups in the Roquette category, for p > 2 Serge Bouc Abstract : Let p be a prime number. In [9], I introduced the Roquette category Rp of finite p-groups, which is an additive tensor category containing all finite p-groups among its objects. In Rp, every finite p-group P admits

  7. Copyright by International OCSCO World Press. All rights reserved. 2006 Research paper 101

    E-Print Network [OSTI]

    Fernandez, Thomas

    manufacturing parameters of RP technologies. Additionally, any user of the PolyJetTM RP machine can use-June 2006 Research paper 101 of Achievements in Materials and Manufacturing Engineering of Achievements in Materials and Manufacturing Engineering Optimizing scale factors of the PolyJetTM rapid prototyping

  8. Department of Energy Carlsbad Field Office

    E-Print Network [OSTI]

    JAN 111010 · Errata 1000071 · Tracking Summary Table MAll ROOM COpy CBFO:ORC:RP:GS:10-0900: UFC 5486 CBFO M&RC *ED denotes electronic distribution JAN 1 2 2010 CBFO:ORC:RP:GS:1().()9OO:UFC 5486.00 #12

  9. A coupled model study of the remote influence of enso on tropical Atlantic sst variability 

    E-Print Network [OSTI]

    Fang, Yue

    2006-08-16

    To investigate the tropical Atlantic response to the remote El Nino-Southern Oscillation (ENSO) forcing, a Reduced Physics Â? Coupled Global Circulation Model (RP-CGCM) is developed, and four experiments are carried out. The results show that the RP...

  10. Rotordynamic coefficients and leakage flow of parallel-grooved liquid-seals 

    E-Print Network [OSTI]

    Kilgore, James Joseph

    1988-01-01

    ? 5300 RP51 6 ? 1200 RPV1 200000 300000 400000 Reynolds number Seal 8 087 06 4~ . 04r 02' Measured Theory 1000 RPM 2000 RPM 3000 RPM 4000 RPM 5300 RPM 1200 RP51 0. 100000 200000 300000 400000 Reynolds number Figure 17 Measured...

  11. Design and Performance Analysis of an Aeronautical Routing Protocol with Ground Station Updates

    E-Print Network [OSTI]

    Narra, Hemanth

    2011-08-31

    Aeronautical routing protocol (AeroRP) is a position-based routing protocol developed for highly dynamic airborne networks. It works in conjunction with the aeronautical network protocol (AeroNP). AeroRP is a multi-modal protocol that operates...

  12. Erk phosphorylates threonine 42 residue of ribosomal protein S3

    SciTech Connect (OSTI)

    Kim, Hag Dong [Laboratory of Biochemistry, School of Life Sciences and Biotechnology, and BioInstitute, Korea University, Seoul 136-701 (Korea, Republic of); Lee, Jae Yung [Department of Biology, Mokpo National University, Chonnam 534-729 (Korea, Republic of); Kim, Joon [Laboratory of Biochemistry, School of Life Sciences and Biotechnology, and BioInstitute, Korea University, Seoul 136-701 (Korea, Republic of)]. E-mail: joonkim@korea.ac.kr

    2005-07-22

    The ribosomal protein S3 (rpS3) is involved in ribosome biogenesis as a member of ribosomal small subunit and also plays a role in the repair of damaged DNA. Extracellular signal-regulated kinase (Erk), a MAP kinase, is known to play important roles in the regulation of cell growth, differentiation, and apoptosis. In this study, the sequence analysis of rpS3 protein revealed that this protein has a putative FXFP motif which is believed to be an Erk binding site. Indeed, the motif was demonstrated as an Erk binding site by co-immunoprecipitation. In addition to this, it was revealed that Erk specifically phosphorylated Thr 42 residue of rpS3 in vitro and in vivo using the various mutants of rpS3. Taken together, rpS3 appears to be phosphorylated by activated Erk in proliferating cells, resulting in the decreased interaction between two proteins.

  13. http://mvr.mcgill.ca/Robert/ rhess_home.html

    E-Print Network [OSTI]

    Hess, Robert F.

    http://mvr.mcgill.ca/Robert/ rhess_home.html #12;Luminance and retinal illumination The range of luminances (left) and retinal illumination (right) found in the natural world Sun Fluorescent light sensitivity functions at three different light levels Spatial Frequency (cycles/mm on retina) Spatial

  14. Review Article Layer-specific anatomical, physiological and functional MRI

    E-Print Network [OSTI]

    Duong, Timothy Q.

    ­3). Starting from the vitreous boundary, they include the ganglion cell layer (GCL), inner plexiform layer (IPL: the retinal and choroidal circulations (1,4,5). Retinal vessels exist in the GCL, INL, IPL and OPL. Choroidal the choroid, has been reported to be $217 mm (2,3) and the choroidal thickness, which is less well documented

  15. First-order design of off-axis reflective ophthalmic adaptive optics systems using afocal

    E-Print Network [OSTI]

    First-order design of off-axis reflective ophthalmic adaptive optics systems using afocal for designing laser cavities, spectrographs and adaptive optics retinal imaging systems. The use, range respectively. This is discussed using examples from adaptive optics retinal imaging systems. The performance

  16. Investigating a C1QTNF5 mutation associated with macular degeneration 

    E-Print Network [OSTI]

    Slingsby, Fern

    2009-01-01

    C1QTNF5 is a 25kDa short chain collagen of unknown function which is mutated in late-onset retinal macular degeneration (L-ORMD). L-ORMD is an autosomal dominant disease characterised by sub-retinal pigment epithelial ...

  17. Vol. 4, No. 8/August 1987/J. Opt. Soc. Am. A 1579 Estimation of local spatial scale

    E-Print Network [OSTI]

    that spatial processing, as manifest in some class of psycho- physical measurements, is homogeneous everywhere. Other studies have relat- ed local scale to the linear density of retinal elements.6 However estimates of cortical or retinal magnification and, indeed, without any prejudice about its

  18. Dictionary Learning-based Volumetric Image Classification for The Diagnosis of Age-related

    E-Print Network [OSTI]

    Coenen, Frans

    -based approach to supporting the classification of 3D Optical Coherence Tomography (OCT) retinal images, so, Spatial gradient his- tograms, diactioanry learning, Medical image processing, Optical Coher- ence of retinal imagery. Traditionally this is conducted using 2-dimensional (2D) colour fundus images

  19. Exploratory Dijkstra forest based automatic vessel segmentation

    E-Print Network [OSTI]

    Tomasi, Carlo

    , and follows vessel branching naturally and efficiently. To test our method, we constructed a retinal video code freely available online. © 2012 Optical Society of America OCIS codes: (100.0100) Image processing, "Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation

  20. The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/b-Catenin Signaling

    E-Print Network [OSTI]

    Birdsey, Graeme M.; Shah, Aarti V.; Dufton, Neil; Reynolds, Louise E.; Almagro, Lourdes Osuna; Yang, Youwen; Aspalter, Irene M.; Khan, Samia T.; Mason, Justin C.; Dejana, Elisabetta; Göttgens, Berthold; Hodivala-Dilke, Kairbaan; Gerhardt, Holger; Adams, Ralf H.; Randi, Anna M.

    2015-01-12

    ) Act of 1986. Postnatal Retinal Angiogenesis Mice were administered Tamoxifen (50 mg per mouse; Sigma) by intraperito- neal injection (IP) at postnatal (P) day 1, P2 and P3. Retinas were collected at P6 and processed as described (Pitulescu et al., 2010... .05, and ***p retinal vasculature of littermate controls (Ergfl/fl), ERGwas...

  1. Nature Macmillan Publishers Ltd 1997 Colour tuning in human visual

    E-Print Network [OSTI]

    Wandell, Brian A.

    processing of these cone signals within the retina and the brain. Perceptual experiments have identified. Midget retinal ganglion cells and parvocellular neurons in the lateral geniculate nucleus (LGN) combine. For example, perceptual spatial resolution is highest for luminance patterns, but the retinal mosaic

  2. Mathematical Medicine and Biology (2006) 23, 79-99 doi:10.1093/imammb/dql003

    E-Print Network [OSTI]

    Eglen, Stephen

    2006-01-01

    processing. For a comprehensive review of retinal architecture and processing, see Rodieck (1998 understanding of the role of these processes upon mosaic formation. Three developmental mechanisms are studied mechanisms might be involved in the formation of retinal ganglion cell mosaics. 1. Nature and formation

  3. Automatic Instrument Tracking Endo-illuminator for Intraocular

    E-Print Network [OSTI]

    Awtar, Shorya

    and manipulate retinal tissue with microsurgical instruments (Fig.1). Because the retina is on average 250 m in thickness and retinal anatomical detail is microscopic, adequate illumination for a clear view of the retina: an image recognition and processing module that uses a live video feed of the surgical feed from

  4. Bacteriorhodopsin: A Natural (Nonlinear) Photonic Bandgap Material

    E-Print Network [OSTI]

    Ozbay, Ekmel

    processing. The two-dimen- sional purple membrane consists of patches of the pro- tein bacteriorhodopsin. The small optical moiety, the retinal chromophore, is embedded in this large protein matrix. The molecular hyperpolarizability of retinal and derivatives was analyzed previously both theoretically and experimentally.3

  5. Bio-Inspired Visuomotor Convergence in Navigation and Flight Control Systems

    E-Print Network [OSTI]

    Murray, Richard M.

    , extraction of global retinal motion cues through computationally efficient wide-field integration process. A fundamental principle contributing to this unparalleled behavior is rapid processing and convergence of visual sensory information to flight motor commands via spatial wide-field integration, accomplished by retinal

  6. SoftwareBased Method for Acquiring Enhanced, Panoramic Images from Video Indirect Ophthalmoscopy for Evaluation of Retinopathy of Prematurity (ROP)

    E-Print Network [OSTI]

    Tomasi, Carlo

    , digitallyenhanced, wide FOV images of the retina from a headmounted VIO taken during neonatal retinal examinations. Methods: Retinal video recordings were taken by headmounted VIO during usual ROP screening examinations, the video camera, or the processing algorithm: 1. Light source reflections appearing as saturated white

  7. Learning of Position-Invariant Object Representation Across Attention Shifts

    E-Print Network [OSTI]

    Clark, James J.

    , such as at different retinal positions or with different appearance due to viewpoint changes. Most research work done the external environment for further processing. Therefore, it is conceivable to hypothesize that the learning attention shifts, with position-related retinal distortions taken into consideration. The need

  8. The Art and Science of Depiction Fredo Durand

    E-Print Network [OSTI]

    Durand, Frédo

    Vision as information processing · Input: retinal image · Output: 3D layout, object recognition, etc. Retinal image Intermediate Data Scene understanding Processing Processing #12;Intro to Visual Perception #12;Intro to Visual Perception 2 Plan · Vision as an cognitive process · Computational theory

  9. 1912 IEEE TRANSACTIONS ON IMAGE PROCESSING, VOL. 20, NO. 7, JULY 2011 VE-LLI-VO: Vessel Enhancement Using Local Line

    E-Print Network [OSTI]

    Chung, Albert C. S.

    1912 IEEE TRANSACTIONS ON IMAGE PROCESSING, VOL. 20, NO. 7, JULY 2011 VE-LLI-VO: Vessel Enhancement synthetic images and retinal images. It is experimentally demonstrated that produces improved performance estimation. Index Terms--Retinal images, vessel enhancement. I. INTRODUCTION OPTIC FUNDUS photography

  10. Nature Macmillan Publishers Ltd 1998 Paired-spike interactions

    E-Print Network [OSTI]

    Reid, R. Clay

    Nature © Macmillan Publishers Ltd 1998 8 Paired-spike interactions and synaptic efficacy of retinal that information encoded in the high firing rate of an individual retinal ganglion cell becomes distributed among is transmitted to the next level of processing. We made simultaneous recordings from 205 pairs of neurons

  11. colour separation in the retina A. M. Labin, E. N. Ribak, S. K. Safuri and I. Perlman

    E-Print Network [OSTI]

    Ribak, Erez

    at the bottom of the retina. Lateral neural layers, for processing the image temporally, spectrally the expected light concentration according to colours. More details: 1. A. M. Labin and E. N. Ribak, "Retinal, "color sorting by retinal waveguides". Optics Express, Accepted (2014) Results: Simulations

  12. INTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS Int. J. Circ. Theor. Appl. 2008; 36:641651

    E-Print Network [OSTI]

    Dudek, Piotr

    high computation speed that is required. Some retinal vessel processing techniques have been proposed:641­651 Published online in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/cta.512 Fast retinal disease diagnosis is an important field in medical research. From the image processing point of view, many

  13. IOP PUBLISHING JOURNAL OF NEURAL ENGINEERING J. Neural Eng. 10 (2013) 056021 (13pp) doi:10.1088/1741-2560/10/5/056021

    E-Print Network [OSTI]

    Palanker, Daniel

    2013-01-01

    restoration to the blind, such as photovoltaic retinal prosthesis, optogenetic and other photoactivation techniques. We compare it with conventional liquid crystal displays (LCD) or digital light processing (DLP only in the online journal) 1. Introduction Retinal degenerative diseases such as age-related macular

  14. Information Processing in the Primate Retina

    E-Print Network [OSTI]

    Chichilnisky, E.J.

    Information Processing in the Primate Retina: Circuitry and Coding G.D. Field and E.J. Chichilnisky, neural coding, synchrony, retinal ganglion cells Abstract The function of any neural circuit is governed on retinal function has substantially advanced understanding in both areas. First, visual information

  15. SENSORIMOTOR CONVERGENCE IN VISUAL NAVIGATION AND FLIGHT CONTROL

    E-Print Network [OSTI]

    Murray, Richard M.

    in the processing of retinal image pattern movement (optic flow) by the visuomotor systems of insects, one of na of optic flow are extracted by retinal motion sensitivity kernels. ditional approach, LPTC-based processing processing and convergence of visual sensory information to flight motor commands via spatial wide

  16. A REAL-TIME SPIKE-DOMAIN SENSORY INFORMATION PROCESSING SYSTEM Udayan Mallik1

    E-Print Network [OSTI]

    Cauwenberghs, Gert

    on the implementation of an autonomous, real-time, combined retinal/cortical system that can process video informa- tion of processing, and has advanced to very sophisticated models of retinal processing and the first layerA REAL-TIME SPIKE-DOMAIN SENSORY INFORMATION PROCESSING SYSTEM Udayan Mallik1 , R. Jacob Vogelstein

  17. Predictive Gaze Stabilization During Periodic Locomotion Using a Feedforward-Feedback Controller based on Adaptive Frequency

    E-Print Network [OSTI]

    Instituto de Sistemas e Robotica

    dealing with robots since most vision processing algorithms reach optimal performance with a stable image as main sensory input to excite a leaky integrator. The remaining retinal slip (usually measured and the retinal slip, and feeding back its output to the brainstem. [9] uses a single neural network excited

  18. This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the

    E-Print Network [OSTI]

    Wessel, Ralf

    is not explicitly encoded at the level of the retinal input. Rather, motion has to be computed from the spatiotemporal intensity changes in the retinal image as sensed by the two-dimensional array of photoreceptors animals with vision have mechanisms for motion processing. Local Motion Processing There are basically two

  19. Double lateral shearing interferometer for the quantitative measurement of tear film topography

    E-Print Network [OSTI]

    Dainty, Chris

    is presented. Simple data processing algorithms are discussed and tested on data illustrating different tear surgery and high-resolution retinal imaging instruments. It is likely that the largest source breakup, like that by Tutt et al.22 showing that the tear breakup affects the contrast of retinal images

  20. Biological Cybernetics manuscript No. (will be inserted by the editor)

    E-Print Network [OSTI]

    Moeller, Ralf

    , a processing pathway without retinal position coding is suggested by the following ex- periment. Carey et al mimics two alternative processing pathways for grasping, which are also likely to co-exist in the human brain. The first path- way uses directly the retinal activation to encode the target position

  1. Visual form perception Peter U. Tse and Howard C. Hughes

    E-Print Network [OSTI]

    Bucci, David J.

    . The fact that retinal processing emphasizes contour information suggests that contours play a crucial role inherently ambiguous 2 dimensional retinal images. How this feat is accomplished is perhaps the most amount of processing is involved in the construction of an internal representation of the visible scene

  2. versity of To of Medical S

    E-Print Network [OSTI]

    Goda, Keisuke

    therapy Associate Professor, Division of Stem Cell Processing & Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, IMSUT Makoto Otsu, M.D., Ph.D. 3 Application of iPS cells to retinal diseases Project Leader, Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN

  3. A generalized linear model of the impact of direct and indirect inputs to the lateral geniculate nucleus

    E-Print Network [OSTI]

    Paninski, Liam

    retinal ganglion cell (RGC), in addition to indirect input from other sources including interneurons in processing visual information remains a matter of debate (Sherman and Guillery, 2002; Carandini et al., 2005 in demonstrating that non-retinal inputs to the relay cells significantly alter LGN activity, and enough is known

  4. Speculative Moves: Multithreading Markov Chain Monte Carlo Programs

    E-Print Network [OSTI]

    Jarvis, Stephen

    used to map muscle cells using Voronoi polygons [3] and tracing retinal vascular trees [4, 5]. The work iterations (approx 4 seconds processing time). of MCMC in solving segmentation problems for prostate many features in large images can take minutes or hours. As an example, the mapping of retinal vascular

  5. Computational Neuroimaging: Color Representations and Processing

    E-Print Network [OSTI]

    Wandell, Brian A.

    Computational Neuroimaging: Color Representations and Processing £ Brian A. Wandell Neuroscience the retinal image as a collection of objects having various perceptual features, including color, motion the retinal image. This chapter reviews the main ideas concerning how color appearance is derived from

  6. SIMULATION MODELLING OF NANOPARTICLE ASSEMBLIES FORMED BY SPRAY DEPOSITION

    E-Print Network [OSTI]

    Bargiela, Andrzej

    processing we have been developing retinal models in order to better understand the structure and function Nanoparticle Assemblies, Roughness, Contact Angle, Superhydrophobicity, Retinal Prosthesis. ABSTRACT This paper nanoparticles via a semi-mechanistic process, which in spite of its simplicity generates morphologies

  7. Predictive Gaze Stabilization During Periodic Locomotion Based On Adaptive Frequency Oscillators

    E-Print Network [OSTI]

    Instituto de Sistemas e Robotica

    the retina slip. The same issue is present when dealing with robots since most vision processing algorithms to excite a leaky integrator. The remaining retinal slip (usually measured by optical flow) is then used sensor, and an artificial cerebellum getting input from the brainstem and the retinal slip, and feeding

  8. A Control-Oriented Analysis of Bio-inspired Visuomotor Convergence1 J. Sean Humbert

    E-Print Network [OSTI]

    Murray, Richard M.

    in the processing of retinal image pattern movement (optic flow) by the visuomotor systems of insects. Insect visual contributing to this amazing behavior is rapid processing and convergence of visual sensory information for wide-field integration of retinal image flow is devel- oped, establishing the connection between image

  9. Brief Communications Reorganization of Visual Processing in Macular

    E-Print Network [OSTI]

    Peli, Eli

    Brief Communications Reorganization of Visual Processing in Macular Degeneration Is Not Specific to the "Preferred Retinal Locus" Daniel D. Dilks,1 Chris I. Baker,2 Eli Peli,3 and Nancy Kanwisher1 1Mc of macular degeneration (MD), begins responding to stimuli presented to a peripheral retinal location

  10. The effect of moving textures on the responses of cells in the cat's dorsal lateral geniculate nucleus

    E-Print Network [OSTI]

    Kiper, Daniel C.

    ¯uence on the degree of suppression. These observations are similar to effects seen on cat retinal ganglion cells al., 1980; Lauritzen et al., 2001). The question arises as to whether earlier stages of processing stimulation on the responses of retinal ganglion cells, mainly suppressive effects have been reported in cat

  11. Brief Communication Reorganization of Visual Processing in

    E-Print Network [OSTI]

    Kanwisher, Nancy

    Brief Communication Reorganization of Visual Processing in Macular Degeneration Chris I. Baker,1. In such cases, the macular damage eliminates the normal retinal input to a large region of visual cortex subjects with extensive bilateral central retinal lesions, we found that parts of visual cortex (including

  12. This information is for the personal use of attendees of the University of Florida Industrial

    E-Print Network [OSTI]

    Van Stryland, Eric

    excision and processing. Optical Biopsy #12;6 OCT ­ Subject Categories Source: Courtesy of Wolfgang Drexler of OCT in Ophthalmology OCT1 (1996) Carl Zeiss Meditec OCT2 (2000) Stratus OCT3 (2002) #12;9 OCT Retinal to optic disc Retinal Pathology 250µm 500 µm Full thickness macular hole Partial thickness or lamellar hole

  13. Method and system for assigning a confidence metric for automated determination of optic disc location

    DOE Patents [OSTI]

    Karnowski, Thomas P. (Knoxville, TN); Tobin, Jr., Kenneth W. (Harriman, TN); Muthusamy Govindasamy, Vijaya Priya (Knoxville, TN); Chaum, Edward (Memphis, TN)

    2012-07-10

    A method for assigning a confidence metric for automated determination of optic disc location that includes analyzing a retinal image and determining at least two sets of coordinates locating an optic disc in the retinal image. The sets of coordinates can be determined using first and second image analysis techniques that are different from one another. An accuracy parameter can be calculated and compared to a primary risk cut-off value. A high confidence level can be assigned to the retinal image if the accuracy parameter is less than the primary risk cut-off value and a low confidence level can be assigned to the retinal image if the accuracy parameter is greater than the primary risk cut-off value. The primary risk cut-off value being selected to represent an acceptable risk of misdiagnosis of a disease having retinal manifestations by the automated technique.

  14. Bridging the Information Gap: Remote Sensing and Micro Hydropower Feasibility in Data-Scarce Regions

    E-Print Network [OSTI]

    Muller, Marc Francois

    2015-01-01

    RP Saini. Cost analysis of low-head dam-toe small hydropowercost estimation of low head run-of-river small hydropowerwith the fact that low- head (and therefore high-flow)

  15. Determining Long-Term Performance of Cool Storage Systems from Short-Term Tests; Literature Review, Preliminary Methodology Description, and Final Site Selection (Final Revision of Nov. 1997 Report) 

    E-Print Network [OSTI]

    Reddy, T. A.; Elleson, J.; Haberl, J. S.; Claridge, D. E.

    1998-01-01

    This preliminary report contains the literature review, a preliminary description of the methodologies that have been chosen for the project and final site selection recommendations for ASHRAE Research Project RP 1004 ~ "Determining Long...

  16. Determining Long-Term Performance of Cool Storage Systems from Short-Term Tests; Literature Review and Site Selection, Nov. 1997 (Revised Feb. 1998) 

    E-Print Network [OSTI]

    Haberl, J. S.; Claridge, D. E.; Reddy, T. A.; Elleson, J.

    1997-01-01

    This is the preliminary report contains the literature review and site selection recommendations for ASHRAE Research Project RP 1004 — "Determining Long-term Performance of Cool Storage Systems From Short-term Tests"....

  17. Synthesis of Graphene Layers from Metal-Carbon Melts: Nucleation and Growth Kinetics

    E-Print Network [OSTI]

    Amini, Shaahin

    2012-01-01

    Transaction of American Foundry Society, 16 (1949) 33. [35]J.F. Wallace, American Foundry Society Transactions, 83 (R.P. Dumphy, W.S. Pellini, Foundry, 50 (1952) 82-86. [90

  18. Energy Efficiency Improvement and Cost Saving Opportunities for the Fruit and Vegetable Processing Industry. An ENERGY STAR Guide for Energy and Plant Managers

    E-Print Network [OSTI]

    Masanet, Eric

    2008-01-01

    efficiency actions, develop an energy management plan forE. Worrell (1995). Clean Energy Technologies: A PreliminarySingh, R.P. (1986a). Energy Accounting in Food Canning

  19. Neuron, Vol. 24, 127141, September, 1999, Copyright 1999 by Cell Press BMPs as Mediators of Roof Plate Repulsion

    E-Print Network [OSTI]

    Butler, Samantha

    Neuron, Vol. 24, 127­141, September, 1999, Copyright ©1999 by Cell Press BMPs as Mediators of Roof., 1997). that the roof plate (RP) expresses a diffusible activity One source of FP-independent guidance

  20. Physical and Chemical Factors Influencing the Transport and Fate of Microorganisms in Soils With Preferential Flow

    E-Print Network [OSTI]

    Wang, Yusong

    2013-01-01

    the breakthrough curve (BTC) for the microbes and bromide,determined from the Br BTC and the transport parameters (Sdescription of the E. coli D21g BTC and RP data (R 2 >0.95

  1. Computational psychiatry: a Rosetta Stone linking the brain to mental illness

    E-Print Network [OSTI]

    Corlett, Philip R.; Fletcher, Paul C.

    2014-08-12

    between patients with schizophrenia, depression, and anorexia nervosa. Cogn Neuropsychiatry 2012; 17: 262–86. 7 Moutoussis M, Bentall RP, El-Deredy W, Dayan P. Bayesian modelling of Jumping-to-Conclusions bias in delusional patients. Cogn...

  2. MA 366 Review - Test # 1

    E-Print Network [OSTI]

    1910-50-91

    (iii) Logistic: dP dt. = rP. (. 1 -. P. K. ) . Practice Problems. 1. Determine the order of each of these differential equations and state whether the equation is linear or

  3. Calculation of the Solar Load onto Occupants in a Room using Bidirectional Scattering Distribution Functions and a View Factor Approach

    E-Print Network [OSTI]

    Jedek, Christoph

    2012-01-01

    J.A. , Beckman, W.A. (1991). Solar engineering of thermalA new method for predicting the solar heat gain of complexfenestration systems. ASHRAE Solar Heat Gain Project 548-RP

  4. Physics is the source of new concepts about the nature of the universe and is a driving force for new technologies. The fundamental physics research of one generation often

    E-Print Network [OSTI]

    Linhardt, Robert J.

    in nanoscience, including energy storage, electronic transport properties and materials. james napolitano, nano and silicon photonics, solid state lighting, solar energy applications. toh-Ming lu r.P. Baker

  5. Bike/ped bridge To Palo Alto

    E-Print Network [OSTI]

    Kay, Mark A.

    TECH R RP To MountainView San Antonio Shopping Center (Walmart,Kohl's, Target and more) SE W P To Menlo TECH Target Walmart Ross Whole Foods SANANTONIORD SHOW ERSDR EL CAMINO REAL CALIFOR NIAST SE Kohl's CVS

  6. Bike/ped bridge To Palo Alto

    E-Print Network [OSTI]

    Kay, Mark A.

    TECH R RP To MountainView San Antonio Shopping Center (Walmart,Kohl's, Target and more) SE W P To Menlo TECH Target Walmart Ross Whole Foods SANANTONIORD SHOW ERSDR EL CAMIN O REAL CALIFOR NIAST SE Kohl

  7. Bike/ped bridge To Palo Alto

    E-Print Network [OSTI]

    Raymond, Jennifer L.

    Tech Center TECH R RP To MountainView San Antonio Shopping Center (Walmart,Kohl's, Target and more) SE 1850 EM BARCADERO RD TECH Byers Eye Institute Target Walmart Ross Whole Foods SANANTONIORD SHOW ERSDR

  8. Artificial Intelligence 119 (2000) 295299 Book Review

    E-Print Network [OSTI]

    Würtz, Rolf P.

    2000-01-01

    Artificial Intelligence 119 (2000) 295­299 Book Review Gossiping Nets 6 Rolf P. Würtz 1 Ruhr;296 R.P. Würtz / Artificial Intelligence 119 (2000) 295­299 Anderson and Rosenfeld present a book

  9. A keyvowel approach to the synthesis of regional accents of English. 

    E-Print Network [OSTI]

    Williams, Briony; Isard, Stephen

    1997-01-01

    Most English text-to-speech synthesisers offer one of only two accents: General American or RP. Developing a new accent is laborious, since it is not possible to choose one accent as a base form and systematically translate ...

  10. Effects of an allatostatin and a myosuppressin on midgut carbohydrate enzyme activity in the cockroach Diploptera punctata

    E-Print Network [OSTI]

    Fuse, Megumi

    of both invertase and -amylase in a dose-dependent fashion in the lumen contents of ligatured midguts-related peptide (FaRP); Cockroach; Diploptera; Invertase; Amylase 1. Introduction The insect midgut (mesenteron

  11. CHARACTERIZATION OF THE ATLAS ROMAN POTS BEAM COUPLING IMPEDANCE AND MECHANICS

    E-Print Network [OSTI]

    . Figure 2: 3D view of a RP unit, side seen from the beam. instabilities and power exchange between longitu- dinal impedances characterize the electromagnetic power exchange between the beam

  12. Compilation of Diversity Factors and Schedules for Energy and Cooling Load Calculations, ASHRAE Research Project 1093, Phase III Draft Report, Compilation of Diversity Factors and Load Shapes 

    E-Print Network [OSTI]

    Abushakra, B.; Haberl, J. S.; Claridge, D. E.; Sreshthaputra, A.

    2000-01-01

    This is a draft of the Final Report in the ASHRAE RP-1093 project that, first summarizes the work completed during the scheduled Phase I and Phase II (presented to the PMSC in Seattle - June 1999, and Dallas February 2000), ...

  13. Rail + Property Development: A model of sustainable transit finance and urbanism

    E-Print Network [OSTI]

    Cervero, Robert; Murakami, Jin

    2008-01-01

    Development and Sustainable Urbanism While R+P projects arehigh-quality and sustainable urbanism is an important by-A model of sustainable transit finance and urbanism Robert

  14. Prelminary Design RM

    Office of Environmental Management (EM)

    (RP-3.3) Are one or more of the following features used for each entrance or access point to a high radiation area where radiation levels exist such that an individual could...

  15. Methodology for the Preliminary Design of High Performance Schools in Hot and Humid Climates 

    E-Print Network [OSTI]

    Im, Piljae

    2010-07-14

    steps include: 1) Using an actual 2006 weather file with measured solar radiation, 2) Modifying lighting & equipment schedule using ASHRAE's RP-1093 methods, 3) Using actual equipment performance curves (i.e., scroll chiller), 4) Using the Winkelmann...

  16. ELLIPSOMETRY AFPO Group Laboratoire de physique des solides -CNRS & Universite Paris Sud-11

    E-Print Network [OSTI]

    Paris-Sud 11, Université de

    : = rp rs = tan()ei Consequences: · ellipsometry is very robust, accurate, and reproducible 1.41 0 PS 1.58 0 3 Brewster microscopy This microscopy technique allows the direct observation

  17. To the measurement of the radius via an electron scattering

    E-Print Network [OSTI]

    B. Wojtsekhowski

    2015-10-04

    We propose an experiment for an accurate measurement of the proton radius. A key feature of our proposal is an iron-free magnetic spectrometer. Projected systematics uncertainties will allow a 1% level accuracy for the $r_p$ value.

  18. 10/2/2006 SLAC-I-760-2A08Z-001-R002 HAZARDOUS WASTE DETERMINATION FORM

    E-Print Network [OSTI]

    Wechsler, Risa H.

    /2/2006 SLAC-I-760-2A08Z-001-R002 HAZARDOUS WASTE DETERMINATION FORM For RP Use Only Hazardous Waste;________________________________________________________________________________________________ 10/2/2006 SLAC-I-760-2A08Z-001-R002 HAZARDOUS WASTE DETERMINATION FORM For RP Use Only Hazardous Waste Codes:Hazardous Classification: [ ] Non-Hazardous [ ] RCRA Waste [ ] Non-RCRA Waste (CA Haz Waste

  19. 1.25-1.75GHZ 1.5 -2.0 GHZ

    E-Print Network [OSTI]

    . SHEET 4) FP FP -10 -10 RP RP 8-T0-1 SWITCH, POL A (SIGNAL SELECTOR FOR PWR METER 2a) 8-T0-1 SWITCH, POL B (SIGNAL SELECTOR FOR PWR METER 2b) FROM AMPS 1-8 POL. B FROM AMPS 1-8 POL. A COUGAR AC582C AMPS 20 RACK 5 COMPUTER READ OUT NOT USED RACK 5 RIGHT HAND PWR METER DUAL-CHANNEL POWER METER #2 HP E4419B

  20. Do Angiotensin-Converting Enzyme Inhibitors Reduce the Risk of Symptomatic Radiation Pneumonitis in Patients With Non-Small Cell Lung Cancer After Definitive Radiation Therapy? Analysis of a Single-Institution Database

    SciTech Connect (OSTI)

    Wang, Hongmei [Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, P.R. of China (China); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang, Yan; Xu, Ting; Nguyen, Quynh-Nhu; Levy, Lawrence B.; O'Reilly, Michael [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gold, Kathryn A. [Department of Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-12-01

    Purpose: Preclinical studies have suggested that angiotensin-converting enzyme inhibitors (ACEIs) can mitigate radiation-induced lung injury. We sought here to investigate possible associations between ACEI use and the risk of symptomatic radiation pneumonitis (RP) among patients undergoing radiation therapy (RT) for non–small cell lung cancer (NSCLC). Methods and Materials: We retrospectively identified patients who received definitive radiation therapy for stages I to III NSCLC between 2004 and 2010 at a single tertiary cancer center. Patients must have received a radiation dose of at least 60 Gy for a single primary lung tumor and have had imaging and dosimetric data available for analysis. RP was quantified according to Common Terminology Criteria for Adverse Events, version 3.0. A Cox proportional hazard model was used to assess potential associations between ACEI use and risk of symptomatic RP. Results: Of 413 patients analyzed, 65 were using ACEIs during RT. In univariate analysis, the rate of RP grade ?2 seemed lower in ACEI users than in nonusers (34% vs 46%), but this apparent difference was not statistically significant (P=.06). In multivariate analysis of all patients, ACEI use was not associated with the risk of symptomatic RP (hazard ratio [HR] = 0.66; P=.07) after adjustment for sex, smoking status, mean lung dose (MLD), and concurrent carboplatin and paclitaxel chemotherapy. Subgroup analysis showed that ACEI use did have a protective effect from RP grade ?2 among patients who received a low (?20-Gy) MLD (P<.01) or were male (P=.04). Conclusions: A trend toward reduction in symptomatic RP among patients taking ACEIs during RT for NSCLC was not statistically significant on univariate or multivariate analyses, although certain subgroups may benefit from use (ie, male patients and those receiving low MLD). The evidence at this point is insufficient to establish whether the use of ACEIs does or does not reduce the risk of RP.

  1. Lecture Notes 8 Jussi Klemela

    E-Print Network [OSTI]

    Klemelä, Jussi

    the portfolio: 1. Maximize the variance penalized expected return ERp t+1 - 2 Var Rp t+1 . where 0 for the expected return: ERp t+1 µ0. 3. Maximize the expected return ERp t+1 under a condition that the vari- ance Var(Rs t+1) = 2 . Then, ERp t+1 - 2 Var(Rp t+1) = µr + b(µ - µr) - 2 b2 2 . Setting the derivative

  2. On the proton charge extensions

    E-Print Network [OSTI]

    Jesse R. Stryker; Gerald A. Miller

    2015-08-26

    We examine how corrections to $S$-state energy levels, $ E_{nS}$, in hydrogenic atoms due to the finite proton size are affected by moments of the proton charge distribution. The corrections to $E_{nS}$ are computed moment by moment. The results demonstrate that the next-to-leading order term in the expansion is of order $r_p / a_B $ times the size of the leading order $ \\langle r_p^2 \\rangle $ term. Our analysis thus dispels any concern that the larger relative size of this term for muonic hydrogen versus electronic hydrogen might account for the outstanding discrepancy of proton radius measurements extracted from the two systems. Furthermore, the next-to-leading order term in powers of $r_p / a_B $ that we derive from a dipole proton form factor is proportional to $\\langle r_p^3 \\rangle $, rather than $\\langle r_p^4 \\rangle$ as would be expected from the scalar nature of the form factor. The dependence of the finite-size correction on $\\langle r_p^3 \\rangle $ and higher odd-power moments is shown to be a general result for any spherically symmetric proton charge distribution. A method for computing the moment expansion of the finite-size correction to arbitrary order is introduced and the results are tabulated for principal quantum numbers up to $n=7$.

  3. A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636

    E-Print Network [OSTI]

    Dangour, Alan D.; Clemens, Felicity; Elbourne, Diana; Fasey, Nicky; Fletcher, Astrid E.; Hardy, Pollyanna; Holder, Graham E.; Huppert, Felicia A.; Knight, Rosemary; Letley, Louise; Richards, Marcus; Truesdale, Ann; Vickers, Madge; Uauy, Ricardo

    2006-08-31

    -chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636] Alan D Dangour*1, Felicity Clemens2, Diana Elbourne2, Nicky Fasey3, Astrid E Fletcher4, Pollyanna Hardy2,5, Graham E Holder6, Felicia A Huppert7, Rosemary Knight3, Louise Letley3, Marcus... will be identical in size, shape, colour and smell for both the intervention and placebo arms of the trial. Given the lack of trial evi- dence to support the use of any particular level of dietary supplementation, the dose selected in the OPAL study was based...

  4. The number and localization of rods and cones in the retina vary widely among species. A rod-dominant distribution

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    ; IPL, inner plexiform layer; IS, inner segment(s); LRAT, lecithin: retinol acyltransferase; Nrl, rod susceptible to light-induced, all-trans-retinal- mediated damage. Previously, we reported that mice lacking

  5. A system for efficient neural stimulation with energy recovery

    E-Print Network [OSTI]

    Kelly, Shawn Kevin, 1973-

    2004-01-01

    An analog VLSI-based low-power neural tissue stimulator is presented as a part of the MIT and Massachusetts Eye and Ear Infirmary Retinal Implant Project to develop a prosthesis for restoring some useful vision to patients ...

  6. Metatranscriptomic and physiological analyses of proteorhodopsin-containing marine flavobacteria

    E-Print Network [OSTI]

    Kim, Hana, S.M. Massachusetts Institute of Technology

    2013-01-01

    Proteorhodopsin (PR) is a seven-helix integral membrane protein that uses retinal as a chromophore. PRs transport protons from the cytoplasmic (CP) to the extracellular (EC) side of the cell membrane utilizing the energy ...

  7. DOE Publishes Technical Brief Clarifying Misconceptions about...

    Energy Savers [EERE]

    LEDs to cause retinal damage, changes to artwork or other media, and stimulation of the human circadian system (which impacts health). Too much exposure to "blue light"-or...

  8. Precision and reliability of cochlear nerve response in mice lacking functional synaptic ribbons

    E-Print Network [OSTI]

    Buran, Bradley N. (Bradley Nicholas)

    2009-01-01

    Synaptic ribbons are electron-dense structures surrounded by vesicles and anchored to the presynaptic membrane of photoreceptors, retinal bipolar cells and hair cells. Ribbon synapses are characterized by sustained exocytosis ...

  9. Enrichment of canine gestation and lactation diets with n-3 polyunsaturated fatty acids to support neurologic development 

    E-Print Network [OSTI]

    Heinemann, Kimberly Michele

    2005-11-01

    Long-chain polyunsaturated fatty acids (LCPUFA) are essential for proper neural and retinal development in many mammalian species. One objective of this research was to investigate the effects of dietary ?-linolenic ...

  10. Probabilistic Models of Phase Variables for Visual Representation and Neural Dynamics

    E-Print Network [OSTI]

    Cadieu, Charles

    2009-01-01

    87(6):2715, 2002. [Bulow and Sommer, 2001] T.Bulow and G. Sommer. Hypercomplex signals-a novel exten-J.A. Hirsch, and F.T. Sommer. Retinal oscillations carry

  11. Anti-tumour activity in RAS-driven tumours by blocking AKT and MEK

    E-Print Network [OSTI]

    Tolcher, Anthony W.; Khan, Khurum; Ong, Michael; Banerji, Udai; Papadimitrakopoulou, Vassiliki; Gandara, David; Patnaik, Amita; Baird, Richard D.; Olmos, David; Garrett, Christopher R.; Skolnik, Jeffrey M.; Rubin, Eric; Smith, Paul; Huang, Pearl; Learoyd, Maria; Shannon, Keith; Morosky, Anne; Tetteh, Ernestina; Jou, Ying-Ming; Papadopoulos, Kyriakos P.; Moreno, Victor; Kaiser, Brianne; Yap, Timothy A.; Yan, Li; de Bono, Johann S.

    2014-12-16

    retinal pigment epithelium detachment. There were no meaningful pharmacokinetic drug-drug interactions. Clinical anti-tumour activity included RECIST 1.0-confirmed partial responses in non-small cell lung cancer and low-grade ovarian carcinoma...

  12. "Main_drv" --2011/10/28 --7:19 --page 1 --#1 Metadata of the chapter that will be visualized online

    E-Print Network [OSTI]

    Nelson, Philip

    algorithm); Retinal ganglion cell (RGC);14 Spacetime pixel (Stixel); Spike identification (Spike15 sorting neurons, cells that are special-19 ized for information processing and communication.20 The output of most

  13. Synapse classification and localization in Electron Micrographs Vignesh Jagadeesh a,

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    from a mammalian retinal tissue compare favorably with state of the art descriptors used for object meta-data such as molecule specific bio-markers used for imaging are critical for further processing

  14. Line and Net Pattern Segmentation Using Shape Modeling Adam Huanga

    E-Print Network [OSTI]

    : Image processing, image enhancement, image segmentation, feature extraction, matched filter, crest lines of blood vessels in retinal images: 1) Blood vessels usually have small curvatures and can be approximated

  15. Neuroinformatics manuscript No. (will be inserted by the editor)

    E-Print Network [OSTI]

    Labate, Demetrio

    -of-the-art algorithms. Keywords Image processing · Automated neuron tracing · Neuron image segmentation D. Jim of a neuron. Clearly, this imaging problem is present in other types of applications such as retinal imaging

  16. Visual Navigation in a Robot using Zig-Zag Behavior

    E-Print Network [OSTI]

    Lewis, M. Anthony

    ,[ ] Neural Information Processing Systems 10, MIT Press 1998 #12;probably prevents the use of this technique- ment, and is the projection of that point on the retinal plane. The velocity of the image of a moving

  17. Mode-locking in a periodically forced integrate-and-fire-or-burst neuron model

    E-Print Network [OSTI]

    the spatial receptive field properties of LGN relay neurons are largely inherited from retinal ganglion cells to investigators that thalamus has an important dynamic role to play in visual processing [4, 5]. For this reason

  18. stereoacuity in processing near and far stimuli 

    E-Print Network [OSTI]

    Wu, Yu-Chieh

    2010-11-14

    ). In contrast, character behind the horopter was presented in UVF, which induces uncrossed retinal disparities (URD). The results showed that males were superior to the information presented on the UVF, while females did not show significant bias. Moreover...

  19. Vision as a Compensatory Mechanism for Disturbance Rejection in Upwind Flight Michael B. Reiser1, J. Sean Humbert2, Mary J. Dunlop, Domitilla Del Vecchio,

    E-Print Network [OSTI]

    Dunlop, Mary

    studies have focused on the visual processing of insects, revealing simple algorithms for collision production of realistic wing kinematics [14], and the higher-level processing in the insect visual system to minimize retinal slip. The p

  20. MICCAI Workshop on: Biophotonics Imaging

    E-Print Network [OSTI]

    , DTU, Denmark #12;51 A bidimensional signal processing approach to vesicle trafficking analysis in 3D, INRA Jouy-en-Josas, France 61 Characterization of pre- and postoperative macular holes from retinal OCT

  1. A visual thalamocortical slice Jason N MacLean, Vivian Fenstermaker, Brendon O Watson & Rafael Yuste

    E-Print Network [OSTI]

    Cai, Long

    for the examination of sensory processing by the cortex1. Retinal ganglion cells project into the lateral geniculate cortex is the first stage of cortical processing of visual input and is the classic model system

  2. Chattering and Differential Signal Processing in Identified Motion-Sensitive Neurons of Parallel Visual Pathways in the Chick Tectum

    E-Print Network [OSTI]

    Wessel, Ralf

    Chattering and Differential Signal Processing in Identified Motion- Sensitive Neurons of Parallel I and type II, con- stitute the major direct inputs to rotundal subdivisions that process various ("chat- tering") to depolarizing current injection. Electrical stimulation of retinal afferents evoked

  3. Optimal dynamical range of excitable networks at criticality

    E-Print Network [OSTI]

    Loss, Daniel

    is that optimal information processing is to be found near phase transitions. However, this heuristic hypothesis and retinal ganglionar cell output. Synchronization and global oscillations also emerge from the network

  4. Synchrony and concerted activity in the neural code of the retina

    E-Print Network [OSTI]

    Shlens, Jonathon

    2007-01-01

    AP Sampath, and F Rieke. Retinal processing near absoluteretinal ganglion cells (RGCs) exhibit strong stimulus-independent correlated activity; the circuits mediating such correlations and the consequences for visual processing

  5. Spatial representation of pitch height: the SMARC effect

    E-Print Network [OSTI]

    Butterworth, Brian

    the inversion of the retinal image forces us to stand on our heads to see the world right side up that crosstalk occurs between written words and pitch at a semantic level of processing, which suggests

  6. Author Identification on the Large Scale David Madigan1,3

    E-Print Network [OSTI]

    of a broader growth within computer science of identification technologies, including biometrics (retinal processing [5, 46] in authorship attribution. These techniques have also been applied to related prob- lems

  7. Speciation through sensory drive in cichlid Ole Seehausen1,2

    E-Print Network [OSTI]

    ), and by its interaction with the amino acid residues lining the retinal-binding pocket of the opsin in which transmission, receiver sensitivity and higher level processing2,20 . Sympatric pairs of closely related

  8. Subject Title: EMF Radiation Safety Program at the

    E-Print Network [OSTI]

    Chan, Hue Sun

    of retinal #12;Subject Title: EMF Radiation Safety Program at the University of Toronto Issued by: Senior, such as cognitive processing, can be affected by induced electric fields below the threshold for direct stimulation

  9. Stereoacuity in processing near or far stimuli 

    E-Print Network [OSTI]

    Wu, Yu-Chieh

    2010-11-24

    ). In contrast, character behind the horopter was presented in UVF, which induces uncrossed retinal disparities (URD). The results showed that males were superior to the information presented on the UVF, while females did not show significant bias. Moreover...

  10. Two research seminars Department of Computer Science & Software Engineering

    E-Print Network [OSTI]

    Hickman, Mark

    .00-16.00, room: Psychology 251 Towards better understanding of retinal information processing The challenge of developing prosthetic eye has been a "holly and information processing questions. In this talk I will outline the recent progress

  11. Association Between White Blood Cell Count Following Radiation Therapy With Radiation Pneumonitis in Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Tang, Chad; Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wang, Hongmei [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou (China); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang, Yan [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Xu, Ting; Nguyen, Quynh; Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-02-01

    Purpose: Radiation pneumonitis (RP) is an inflammatory response to radiation therapy (RT). We assessed the association between RP and white blood cell (WBC) count, an established metric of systemic inflammation, after RT for non-small cell lung cancer. Methods and Materials: We retrospectively analyzed 366 patients with non-small cell lung cancer who received ?60 Gy as definitive therapy. The primary endpoint was whether WBC count after RT (defined as 2 weeks through 3 months after RT completion) was associated with grade ?3 or grade ?2 RP. Median lung volume receiving ?20 Gy (V{sub 20}) was 31%, and post-RT WBC counts ranged from 1.7 to 21.2 × 10{sup 3} WBCs/?L. Odds ratios (ORs) associating clinical variables and post-RT WBC counts with RP were calculated via logistic regression. A recursive-partitioning algorithm was used to define optimal post-RT WBC count cut points. Results: Post-RT WBC counts were significantly higher in patients with grade ?3 RP than without (P<.05). Optimal cut points for post-RT WBC count were found to be 7.4 and 8.0 × 10{sup 3}/?L for grade ?3 and ?2 RP, respectively. Univariate analysis revealed significant associations between post-RT WBC count and grade ?3 (n=46, OR=2.6, 95% confidence interval [CI] 1.4?4.9, P=.003) and grade ?2 RP (n=164, OR=2.0, 95% CI 1.2?3.4, P=.01). This association held in a stepwise multivariate regression. Of note, V{sub 20} was found to be significantly associated with grade ?2 RP (OR=2.2, 95% CI 1.2?3.4, P=.01) and trended toward significance for grade ?3 RP (OR=1.9, 95% CI 1.0-3.5, P=.06). Conclusions: Post-RT WBC counts were significantly and independently associated with RP and have potential utility as a diagnostic or predictive marker for this toxicity.

  12. Accepted Manuscript Comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient

    E-Print Network [OSTI]

    Boyer, Edmond

    Accepted Manuscript Comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age- related retinal on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age- related retinal

  13. Rest period duration of the coronary arteries: Implications for magnetic resonance coronary angiography

    SciTech Connect (OSTI)

    Shechter, Guy; Resar, Jon R.; McVeigh, Elliot R. [Lab of Cardiac Energetics, NHLBI, NIH Building 10, Room B1D-412, msc-1061, Bethesda, Maryland 20892-1061 (United States); Division of Cardiology, Department of Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 524B, Baltimore, Maryland 21287 (United States); Lab of Cardiac Energetics, NHLBI, NIH Building 10, Room B1D-412, msc-1061, Bethesda, Maryland 20892-1061 (United States)

    2005-01-01

    Magnetic resonance (MR) and computed tomography coronary imaging is susceptible to artifacts caused by motion of the heart. The presence of rest periods during the cardiac and respiratory cycles suggests that images free of motion artifacts could be acquired. In this paper, we studied the rest period (RP) duration of the coronary arteries during a cardiac contraction and a tidal respiratory cycle. We also studied whether three MR motion correction methods could be used to increase the respiratory RP duration. Free breathing x-ray coronary angiograms were acquired in ten patients. The three-dimensional (3D) structure of the coronary arteries was reconstructed from a biplane acquisition using stereo reconstruction methods. The 3D motion of the arterial model was then recovered using an automatic motion tracking algorithm. The motion field was then decomposed into separate cardiac and respiratory components using a cardiac respiratory parametric model. For the proximal-to-middle segments of the right coronary artery (RCA), a cardiac RP (<1 mm 3D displacement) of 76{+-}34 ms was measured at end systole (ES), and 65{+-}42 ms in mid-diastole (MD). The cardiac RP was 80{+-}25 ms at ES and 112{+-}42 ms at MD for the proximal 5 cm of the left coronary tree. At end expiration, the respiratory RP (in percent of the respiratory period) was 26{+-}8% for the RCA and 27{+-}17% for the left coronary tree. Left coronary respiratory RP (<0.5 mm 3D displacement) increased with translation (32% of the respiratory period), rigid body (51%), and affine (79%) motion correction. The RCA respiratory RP using translational (27%) and rigid body (33%) motion correction were not statistically different from each other. Measurements of the cardiac and respiratory rest periods will improve our understanding of the temporal and spatial resolution constraints for coronary imaging.

  14. Serum Amyloid A as a Predictive Marker for Radiation Pneumonitis in Lung Cancer Patients

    SciTech Connect (OSTI)

    Wang, Yu-Shan [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China) [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Department of Animal Science, National Ilan University, Ilan, Taiwan (China); Chang, Heng-Jui [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Chang, Yue-Cune [Department of Mathematics, Tamkang University, Taipei, Taiwan (China)] [Department of Mathematics, Tamkang University, Taipei, Taiwan (China); Huang, Su-Chen; Ko, Hui-Ling; Chang, Chih-Chia [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Yeh, Yu-Wung; Jiang, Jiunn-Song [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Lee, Cheng-Yen; Chi, Mau-Shin [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China)] [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Chi, Kwan-Hwa, E-mail: M006565@ms.skh.org.tw [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China) [Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Institute of Radiation Science and School of Medicine, National Yang-Ming University, Taipei, Taiwan (China)

    2013-03-01

    Purpose: To investigate serum markers associated with radiation pneumonitis (RP) grade ?3 in patients with lung cancer who were treated with radiation therapy. Methods and Materials: Pretreatment serum samples from patients with stage Ib-IV lung cancer who developed RP within 1 year after radiation therapy were analyzed to identify a proteome marker able to stratify patients prone to develop severe RP by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). Dosimetric parameters and 3 biological factors were compared. Results: Serum samples from 16 patients (28%) with severe RP (grade 3-4) and 42 patients (72%) with no or mild RP (grade 0-2) were collected for analysis. All patients received a median of 54 Gy (range, 42-70 Gy) of three-dimensional conformal radiation therapy with a mean lung dose (MLD) of 1502 cGy (range, 700-2794 cGy). An m/z peak of 11,480 Da was identified by SELDI-TOF-MS, and serum amyloid A (SAA) was the primary splitter serum marker. The receiver operating characteristic area under the curve of SAA (0.94; 95% confidence interval [CI], 0.87-1.00) was higher than those of C-reactive protein (0.83; 95% CI, 0.72-0.94), interleukin-6 (0.79; 95% CI, 0.65-0.94), and MLD (0.57; 95% CI, 0.37-0.77). The best sensitivity and specificity of combined SAA and MLD for predicting RP were 88.9% and 96.0%, respectively. Conclusions: Baseline SAA could be used as an auxiliary marker for predicting severe RP. Extreme care should be taken to limit the lung irradiation dose in patients with high SAA.

  15. EVALUATION OF SPRING OPERATED RELIEF VALVE MAINTENANCE INTERVALS AND EXTENSION OF MAINTENANCE TIMES USING A WEIBULL ANALYSIS WITH MODIFIED BAYESIAN UPDATING

    SciTech Connect (OSTI)

    Harris, S.; Gross, R.; Mitchell, E.

    2011-01-18

    The Savannah River Site (SRS) spring operated pressure relief valve (SORV) maintenance intervals were evaluated using an approach provided by the American Petroleum Institute (API RP 581) for risk-based inspection technology (RBI). In addition, the impact of extending the inspection schedule was evaluated using Monte Carlo Simulation (MCS). The API RP 581 approach is characterized as a Weibull analysis with modified Bayesian updating provided by SRS SORV proof testing experience. Initial Weibull parameter estimates were updated as per SRS's historical proof test records contained in the Center for Chemical Process Safety (CCPS) Process Equipment Reliability Database (PERD). The API RP 581 methodology was used to estimate the SORV's probability of failing on demand (PFD), and the annual expected risk. The API RP 581 methodology indicates that the current SRS maintenance plan is conservative. Cost savings may be attained in certain mild service applications that present low PFD and overall risk. Current practices are reviewed and recommendations are made for extending inspection intervals. The paper gives an illustration of the inspection costs versus the associated risks by using API RP 581 Risk Based Inspection (RBI) Technology. A cost effective maintenance frequency balancing both financial risk and inspection cost is demonstrated.

  16. Modeling of Radiation Pneumonitis after Lung Stereotactic Body Radiotherapy: A Bayesian Network Approach

    E-Print Network [OSTI]

    Lee, Sangkyu; Jeyaseelan, Krishinima; Faria, Sergio; Kopek, Neil; Brisebois, Pascale; Vu, Toni; Filion, Edith; Campeau, Marie-Pierre; Lambert, Louise; Del Vecchio, Pierre; Trudel, Diane; El-Sokhn, Nidale; Roach, Michael; Robinson, Clifford; Naqa, Issam El

    2015-01-01

    Background and Purpose: Stereotactic body radiotherapy (SBRT) for lung cancer accompanies a non-negligible risk of radiation pneumonitis (RP). This study presents a Bayesian network (BN) model that connects biological, dosimetric, and clinical RP risk factors. Material and Methods: 43 non-small-cell lung cancer patients treated with SBRT with 5 fractions or less were studied. Candidate RP risk factors included dose-volume parameters, previously reported clinical RP factors, 6 protein biomarkers at baseline and 6 weeks post-treatment. A BN ensemble model was built from a subset of the variables in a training cohort (N=32), and further tested in an independent validation cohort (N=11). Results: Key factors identified in the BN ensemble for predicting RP risk were ipsilateral V5, lung volume receiving more than 105% of prescription, and decrease in angiotensin converting enzyme (ACE) from baseline to 6 weeks. External validation of the BN ensemble model yielded an area under the curve of 0.8. Conclusions: The BN...

  17. Solar Wind at 33 AU: Setting Bounds on the Pluto Interaction for New Horizons

    E-Print Network [OSTI]

    Bagenal, F; Elliott, H A; Hill, M E; Lisse, C M; McComas, D J; McNutt,, R L; Richardson, J D; Smith, C W; Strobel, D F

    2015-01-01

    The NASA New Horizons spacecraft flies past Pluto on July 14, 2015, carrying two instruments that detect charged particles. Pluto has a tenuous, extended atmosphere that is escaping the weak gravity of the planet. The interaction of the solar wind with the escaping atmosphere of Pluto depends on solar wind conditions as well as the vertical structure of the atmosphere. We have analyzed Voyager 2 particles and fields measurements between 25 and 39 AU and present their statistical variations. We have adjusted these predictions to allow for the declining activity of the Sun and solar wind output. We summarize the range of SW conditions that can be expected at 33 AU and survey the range of scales of interaction that New Horizons might experience. Model estimates for the solar wind stand-off distance vary from approximately 7 to 1000 RP with our best estimate being around 40 RP (where we take the radius of Pluto to be RP=1184 km).

  18. Environment-induced anisotropy and the sensitivity of the radical pair mechanism in the avian compass

    E-Print Network [OSTI]

    Alejandro Carrillo; Marcio F. Cornelio; Marcos C. de Oliveira

    2015-08-07

    Several experiments over the years have shown that the Earth's magnetic field is essential for orientation in birds migration. The most promising explanation for this orientation is the photo-stimulated radical pair (RP) mechanism. In order to define a reference frame for the orientation task radicals must have an intrinsic anisotropy. We show that this kind of anisotropy, and consequently the entanglement in the model, are not necessary for the proper functioning of the compass. Classically correlated initial conditions for the RP, subjected to a fast decoherence process, are able to provide the anisotropy required. Even a dephasing environment can provide the necessary frame for the compass to work, and also implies fast decay of any quantum correlation in the system without damaging the orientation ability. This fact significantly expands the range of applicability of the RP mechanism providing more elements for experimental search.

  19. Effects of nonlinearity and wave directionality on the use of Morison equation 

    E-Print Network [OSTI]

    Chen, Weida

    1993-01-01

    Bu Bv, C, pV ? + C, pV(u ? + v ? )+ C, pVrv- Bt Bz By Bz C rpV a, + C, pV. a. , + C, pV (z) (s) (r) (90) In equation (90) 8r. (91), a?a, r, a, z in the equation above are the s. ccelerations from the i direction. Bv Bv Bv Fv ? 2p'V ? + 2p...V(u ? + v ? ) Bt Bz By Bv Bv C, pV ? + C, pV(v ? + Bt Bv + pVrv- Bz Bv Bv v ? ) + C~zpVw- By Bz C rpV a, + C rpV a, r + C zpV a? (z) (z) (s) (91) where as, a, r, a, z in the equation above are the accelerations I'rom the i direction. Therefore...

  20. Correlation of rocket propulsion fuel properties with chemical composition using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry followed by partial least squares regression analysis

    SciTech Connect (OSTI)

    Kehimkar, Benjamin; Hoggard, Jamin C.; Marney, Luke C.; Billingsley, Matthew; Fraga, Carlos G.; Bruno, Thomas J.; Synovec, Robert E.

    2014-01-31

    There is an increased need to more fully assess and control the composition of kerosene based rocket propulsion fuels, namely RP-1 and RP-2. In particular, it is crucial to be able to make better quantitative connections between the following three attributes: (a) fuel performance, (b) fuel properties (flash point, density, kinematic viscosity, net heat of combustion, hydrogen content, etc) and (c) the chemical composition of a given fuel (i.e., specific chemical compounds and compound classes present as a result of feedstock blending and processing). Indeed, recent efforts in predicting fuel performance through modeling put greater emphasis on detailed and accurate fuel properties and fuel compositional information. In this regard, advanced distillation curve (ADC) metrology provides improved data relative to classical boiling point and volatility curve techniques. Using ADC metrology, data obtained from RP-1 and RP-2 fuels provides compositional variation information that is directly relevant to predictive modeling of fuel performance. Often, in such studies, one-dimensional gas chromatography (GC) combined with mass spectrometry (MS) is typically employed to provide chemical composition information. Building on approaches using GC-MS, but to glean substantially more chemical composition information from these complex fuels, we have recently studied the use of comprehensive two dimensional gas chromatography combined with time-of-flight mass spectrometry (GC × GC - TOFMS) to provide chemical composition data that is significantly richer than that provided by GC-MS methods. In this report, by applying multivariate data analysis techniques, referred to as chemometrics, we are able to readily model (correlate) the chemical compositional information from RP-1 and RP-2 fuels provided using GC × GC - TOFMS, to the fuel property information such as that provided by the ADC method and other specification properties. We anticipate that this new chemical analysis strategy will have broad implications for the development of high fidelity composition-property models, leading to an optimized approach to fuel formulation and specification for advanced engine cycles.

  1. Control of linear modes in cylindrical resistive magnetohydrodynamics with a resistive wall, plasma rotation, and complex gain

    SciTech Connect (OSTI)

    Brennan, D. P. [Department of Astrophysical Sciences, Princeton University, Princeton, New Jersey 08544 (United States); Finn, J. M. [Applied Mathematics and Plasma Physics, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

    2014-10-15

    Feedback stabilization of magnetohydrodynamic (MHD) modes in a tokamak is studied in a cylindrical model with a resistive wall, plasma resistivity, viscosity, and toroidal rotation. The control is based on a linear combination of the normal and tangential components of the magnetic field just inside the resistive wall. The feedback includes complex gain, for both the normal and for the tangential components, and it is known that the imaginary part of the feedback for the former is equivalent to plasma rotation [J. M. Finn and L. Chacon, Phys. Plasmas 11, 1866 (2004)]. The work includes (1) analysis with a reduced resistive MHD model for a tokamak with finite ? and with stepfunction current density and pressure profiles, and (2) computations with a full compressible visco-resistive MHD model with smooth decreasing profiles of current density and pressure. The equilibria are stable for ??=?0 and the marginal stability values ?{sub rp,rw}?rp,iw} rp,iw} because rotation suppresses the diffusion of flux from the plasma out through the wall and, more surprisingly, (b) rotation or imaginary gain with normal sensors destabilizes above ?{sub rp,iw} because it prevents the feedback flux from entering the plasma through the resistive wall to form a virtual wall. A method of using complex gain G{sub i} to optimize in the presence of rotation in this regime with ??>??{sub rp,iw} is presented. The effect of imaginary gain with tangential sensors is more complicated but essentially destabilizes above and below ?{sub rp,iw}.

  2. Functional Promoter Variant rs2868371 of HSPB1 Is Associated With Risk of Radiation Pneumonitis After Chemoradiation for Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Pang, Qingsong; Department of Radiation Oncology and Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin ; Wei, Qingyi; Xu, Ting; Yuan, Xianglin; Lopez Guerra, Jose Luis; Levy, Lawrence B.; Liu, Zhensheng; Gomez, Daniel R.; Zhuang, Yan; Wang, Li-E.; Mohan, Radhe; Komaki, Ritsuko; Liao, Zhongxing

    2013-04-01

    Purpose: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single nucleotide polymorphisms (SNPs) in HSPB1 and risk of RP after chemoradiation for non-small cell lung cancer (NSCLC). Methods and Materials: Subjects were patients with NSCLC treated with chemoradiation at 1 institution. The training data set comprised 146 patients treated from 1999 to July 2004; the validation data set was 125 patients treated from August 2004 to March 2010. We genotyped 2 functional SNPs of HSPB1 (rs2868370 and rs2868371) from all patients. We used Kaplan-Meier analysis to assess the risk of grade ?2 or ?3 RP in both data sets and a parametric log-logistic survival model to evaluate the association of HSPB1 genotypes with that risk. Results: Grade ?3 RP was experienced by 13% of those with CG/GG and 29% of those with CC genotype of HSPB1 rs2868371 in the training data set (P=.028); corresponding rates in the validation data set were 2% CG/GG and 14% CC (P=.02). Univariate and multivariate analysis confirmed the association of CC of HSPB1 rs2868371 with higher risk of grade ?3 RP than CG/GG after adjustment for sex, age, performance status, and lung mean dose. This association was validated both in the validation data set and with Harrell's C statistic. Conclusions: The CC genotype of HSPB1 rs2868371 was associated with severe RP after chemoradiation for NSCLC.

  3. Growth of Ca{sub 2}MnO{sub 4} Ruddlesden-Popper structured thin films using combinatorial substrate epitaxy

    SciTech Connect (OSTI)

    Lacotte, M.; David, A.; Pravarthana, D.; Prellier, W.; Grygiel, C.; Rohrer, G. S.; Salvador, P. A.; Velazquez, M.; Kloe, R. de

    2014-12-28

    The local epitaxial growth of pulsed laser deposited Ca{sub 2}MnO{sub 4} films on polycrystalline spark plasma sintered Sr{sub 2}TiO{sub 4} substrates was investigated to determine phase formation and preferred epitaxial orientation relationships (ORs) for isostructural Ruddlesden-Popper (RP) heteroepitaxy, further developing the high-throughput synthetic approach called Combinatorial Substrate Epitaxy (CSE). Both grazing incidence X-ray diffraction and electron backscatter diffraction patterns of the film and substrate were indexable as single-phase RP-structured compounds. The optimal growth temperature (between 650?°C and 800?°C) was found to be 750?°C using the maximum value of the average image quality of the backscattered diffraction patterns. Films grew in a grain-over-grain pattern such that each Ca{sub 2}MnO{sub 4} grain had a single OR with the Sr{sub 2}TiO{sub 4} grain on which it grew. Three primary ORs described 47 out of 49 grain pairs that covered nearly all of RP orientation space. The first OR, found for 20 of the 49, was the expected RP unit-cell over RP unit-cell OR, expressed as [100][001]{sub film}||[100][001]{sub sub}. The other two ORs were essentially rotated from the first by 90°, with one (observed for 17 of 49 pairs) being rotated about the [100] and the other (observed for 10 of 49 pairs) being rotated about the [110] (and not exactly by 90°). These results indicate that only a small number of ORs are needed to describe isostructural RP heteroepitaxy and further demonstrate the potential of CSE in the design and growth of a wide range of complex functional oxides.

  4. Stereotactic Body Radiation Therapy Can Be Used Safely to Boost Residual Disease in Locally Advanced Non-Small Cell Lung Cancer: A Prospective Study

    SciTech Connect (OSTI)

    Feddock, Jonathan; Arnold, Susanne M.; Department of Medical Oncology, University of Kentucky, Lexington, Kentucky ; Shelton, Brent J.; Sinha, Partha; Conrad, Gary; Chen, Li; Rinehart, John; McGarry, Ronald C.

    2013-04-01

    Purpose: To report the results of a prospective, single-institution study evaluating the feasibility of conventional chemoradiation (CRT) followed by stereotactic body radiation therapy (SBRT) as a means of dose escalation for patients with stage II-III non-small cell lung cancer (NSCLC) with residual disease. Methods and Materials: Patients without metastatic disease and with radiologic evidence of limited residual disease (?5 cm) within the site of the primary tumor and good or complete nodal responses after standard CRT to a target dose of 60 Gy were considered eligible. The SBRT boost was done to achieve a total combined dose biological equivalent dose >100 Gy to the residual primary tumor, consisting of 10 Gy × 2 fractions (20 Gy total) for peripheral tumors, and 6.5 Gy × 3 fractions (19.5 Gy total) for medial tumors using the Radiation Therapy Oncology Group protocol 0813 definitions. The primary endpoint was the development of grade ?3 radiation pneumonitis (RP). Results: After a median follow-up of 13 months, 4 patients developed acute grade 3 RP, and 1 (2.9%) developed late and persistent grade 3 RP. No patients developed grade 4 or 5 RP. Mean lung dose, V2.5, V5, V10, and V20 values were calculated for the SBRT boost, and none were found to significantly predict for RP. Only advancing age (P=.0147), previous smoking status (P=.0505), and high CRT mean lung dose (P=.0295) were significantly associated with RP development. At the time of analysis, the actuarial local control rate at the primary tumor site was 82.9%, with only 6 patients demonstrating recurrence. Conclusions: Linear accelerator-based SBRT for dose escalation of limited residual NSCLC after definitive CRT was feasible and did not increase the risk for toxicity above that for standard radiation therapy.

  5. Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases

    E-Print Network [OSTI]

    Lin, Xiaoyan; Thorne, Lucy; Jin, Zhinan; Hammad, Loubna A.; Li, Serena; Deval, Jerome; Goodfellow, Ian G.; Kao, C. Cheng

    2014-12-17

    Rp in the presence of increasing concentrations of three competitor RNAs, Chp, Ghp and Mhp. Comparable results were obtained in three independent experiments. (E) Deletions in the hairpin within Mps severely reduced de novo initiated RNA synthesis. The gel image... Rp in the presence of increasing concentrations of three competitor RNAs, Chp, Ghp and Mhp. at U niversity of Cam bridge on February 11, 2015 http://nar.oxfordjournals.org/ D ow nloaded from Nucleic Acids Research, 2014 7 We sought to determine whether...

  6. Quantum models with spectrum generated by the flows of polynomial zeros

    E-Print Network [OSTI]

    Alexander Moroz

    2014-10-27

    A class {\\cal R}_p of purely bosonic models is characterized having the following properties in the Bargmann Hilbert space of analytic functions: (i) wave function \\psi(\\epsilon,z)=\\sum_{n=0}^\\infty \\phi_n(\\epsilon) z^n is the {\\em generating function} for orthogonal polynomials \\phi_n(\\epsilon) of a discrete energy variable \\epsilon, (ii) any Hamiltonian \\hat{H}_b\\in {\\cal R}_p has nondegenerate purely point spectrum that corresponds to infinite discrete support of measure d\

  7. Pneumatic vibratory cleaner conveyor for sugarcane 

    E-Print Network [OSTI]

    Oliveira, Roberto Costa de

    1983-01-01

    physical positions, each of which demand a particular set of equations of motion. Those billet physical positions are: 1. Friction with the conveyor bed. 2. Impact on the flap. 3. F iction with the flap without influence of air jet. 4. Free flight. 5... the system of the three equations [31], [32] and [33] for the three unknowns yields: ()* = [rP + 2(s-x)] I 3r [34] z* = s ? rP* [36] y* = sy [36] With these results, the no slip assumption can be tested: F . . = ~F x n~ & uF n friction where F...

  8. An Experimental Study into the Ignition of Methane and Ethane Blends in a New Shock-tube Facility 

    E-Print Network [OSTI]

    Aul, Christopher Joseph Erik

    2011-02-22

    pump for driver section GRI Gas Research Institute NTC negative temperature coefficient PT pressure transducer RCM rapid compression machine RMS root-mean square RP roughing pump for driven section TP turbomolecular pump for driven section ix... Turbomolecular PumpTP Backing PumpBP Roughing PumpRP Driver PumpDP Diaphragm Location Inertial Mass (7,700 kg) Figure 2. Shock tube facility with two available configurations shown The total facility consists of the shock-tube hardware, control system, data...

  9. Association study of schizophrenia and IL-2 receptor {beta} chain gene

    SciTech Connect (OSTI)

    Nimgaonkar, V.L.; Yang, Z.W.; Zhang, X.R.; Brar, J.S.

    1995-10-09

    A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2RP chain gene, were examined in both groups. No significant differences in IL-2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2RP gene locus, contrary to the suggestive evidence from linkage analysis in multicase families. 17 refs., 2 tabs.

  10. Operational Radiation Protection in High-Energy Physics Accelerators

    SciTech Connect (OSTI)

    Rokni, S.H.; Fasso, A.; Liu, J.C.; /SLAC

    2012-04-03

    An overview of operational radiation protection (RP) policies and practices at high-energy electron and proton accelerators used for physics research is presented. The different radiation fields and hazards typical of these facilities are described, as well as access control and radiation control systems. The implementation of an operational RP programme is illustrated, covering area and personnel classification and monitoring, radiation surveys, radiological environmental protection, management of induced radioactivity, radiological work planning and control, management of radioactive materials and wastes, facility dismantling and decommissioning, instrumentation and training.

  11. Biocompatible implants and methods of making and attaching the same

    DOE Patents [OSTI]

    Rowley, Adrian P; Laude, Lucien D; Humayun, Mark S; Weiland, James D; Lotfi, Atoosa; Markland, Jr., Francis S

    2014-10-07

    The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.

  12. United management of groups of farms in the Middle West and Texas 

    E-Print Network [OSTI]

    Orr, William Bassett

    1933-01-01

    ' XHVHSTHRRT Huaber of Reyorts Hntent to Shish Operating Hn pensee are puraishad bp Caner Returas an Owners' Inrsstaeat (yer oent) adllN SoQ aV?rp Little" Sad ul4 14 1n Ge asserting to the rsyorts, aoet tares under oonsiderat1on 1n this study...

  13. The effects of cattle on shoreline vegetation of ponds and tanks in south Texas 

    E-Print Network [OSTI]

    Whyte, Richard John

    1978-01-01

    4. 5 i2 Q7 50 i6 5i Ln n e Zone [ ong+o. . . Zone I' stores;. caner&wee ~ I gooati~ Zone (8) Low water level Range Zone Lor, gtorn Zone Knotg ass-Sea twoeo Zone . . r~p+, &i?& ~+~", r ~ Tran-. ition Zone I i ~i' (g r(Pne '"' p T'ne yo, k...

  14. CHARACTERIZATION Volume 1: Report

    E-Print Network [OSTI]

    #12;EFFLUENT CHARACTERIZATION STUDY Volume 1: Report for FRASER RIVER ESTUARY MANAGEMENT PROGRAM Report No.: F07201RP.J11 #12;EFFLUENT CHARACTERIZATION STUDY i PREFACE The Fraser River Estuary Resource Inc. (TRI) was contracted to characterize the effluent from eleven industrial sites. Mc

  15. 46 (2009-6) Effect of Surface Roughness on Emittance Spectra of Metal-coated Silicon Microcavity

    E-Print Network [OSTI]

    Kasagi, Nobuhide

    to the electromagnetic resonance mode. When InGaAsSb PV cell is assumed, theoretical conversion efficiency becomes 31-372 infrared heat lamp sample & sample holder vacuum chamber IR spectrometer silver-coated mirror sapphire window lock-in amplifiervacuum pumping system data logger radiation oval mirror RP TMP radiation

  16. Mem. S.A.It. Vol. 73, 23 SAIt 2002 Memorie della

    E-Print Network [OSTI]

    - physical environments. Our group is collab- orating with the Center for Astrophysical Thermonuclear Flashes, and energy conservation are in the form: @#26; @t +r #1; #26;v = 0 @#26;v @t +r #1; #26;vv +rP = #26;g +r #1 is the total plasma energy (internal en- ergy #15; plus kinetic) per unit mass, #26; is the plasma mass density

  17. ENERGY MANAGEMENT REPORT NOVEMBER 2015

    E-Print Network [OSTI]

    Matlack, Raymond S.

    initiatives have helped the main campus source Energy Use Index (EUI) stay flat from 156 mBtu per square foot in November, 2012 to 159.6 mBtu per square foot in August, 2015. B. The steps the agency may take to increaseENERGY MANAGEMENT REPORT NOVEMBER 2015 #12;Executive Order RP-49 Energy Management Report

  18. Signaling pathways that regulate cellular senescence

    E-Print Network [OSTI]

    Freund, Adam Mark

    2010-01-01

    Acrp30 Angiogenin Axl bFGF BLC BTC CTACK EGF-­?R Fas DDIS  (bFGF Angiopoie?n-­?2 AgRP BTC VEGF Amphiregulin HCC-­?4gamma MSP-­alpha NT-­4 bFGF BTC MIF TNF-­beta MIG b-­NGF

  19. Energies 2012, 5, 5065-5085; doi:10.3390/en5125065 ISSN 1996-1073

    E-Print Network [OSTI]

    in Northwestern Ontario, Canada Md. Bedarul Alam 1, *, Reino Pulkki 1,2 , Chander Shahi 1 and Thakur Upadhyay 1 11, Canada; E-Mails: rpulkki@lakeheadu.ca (R.P.); cshahi@lakeheadu.ca (C.S.); tpupadhy) in northwestern Ontario (NWO) to replace lignite coal with renewable woody biomass as feedstock by 2014. The AGS

  20. Approximating the Visible Region of a Point on a Terrain Boaz Ben-Moshe

    E-Print Network [OSTI]

    Ben-Moshe, Boaz

    enough; that is, whenever the difference between the sets of visible segments along the cross sections computes the (projections of the) visible por- tions of the cross section of T in this direc§ Abstract Given a terrain T and a point p on or above it, we wish to compute the region Rp that is visible

  1. Sex Differences in the Genetic Basis of Morning Serum Cortisol Levels: Genome-Wide Screen Identifies Two

    E-Print Network [OSTI]

    Abney, Mark

    in a cohort of middle-aged Swedish men. Moreover, cross- sectional studies have identified associations; School of Medicine (R.P.), University of South Dakota, Sioux Falls, South Dakota 57105 practice a communal, farming lifestyle in the western United States and in Canada. Hutterites (n 504, 53

  2. National Centre for Earth Observation, Publications 2008 National Centre for Earth Observation Publications 2008

    E-Print Network [OSTI]

    :213, British Geological Survey Report no. CR/08/179, 48pp. Aiken, J., Hardman-Mountford, N.J., Barlow remote sensing. Journal of Plankton Research 30: 165-182. Allan, R.P. and Soden, B.J. (2008) Atmospheric. Bösch, S.C. Doney, and D.S. Schimel, (2008) Carbon source/sink information provided by column CO2

  3. ASHRAE Research PROGRAM OVERVIEW

    E-Print Network [OSTI]

    Oak Ridge National Laboratory

    : · Indoor Environmental Quality (IEQ) · Sustainability: Solar, Geothermal, Heat Pumps, Fuel Cells, CHP, etc of appliances , such as heat pump water heaters 2. Our equipment rating methods are (at best) obsolete. #12;Heat Pump Research · RP-247, A Solar Heat Pump Heating System with Latent Heat Storage for Cold

  4. Informatica Biomedica: desafios e perspectivas Daniel Weingaertner

    E-Print Network [OSTI]

    Inform´atica Biom´edica: desafios e perspectivas Daniel Weingaertner Departamento de Inform´atica ­ UFPR Centro de Computa¸c~ao Cient´ifica e Software Livre ­ C3SL Semana de Inform´atica Biom´edica 03, Jim not a . . . " Daniel Weingaertner (C3SL-UFPR) USP-RP 7 / 10 #12;Inform´atica Biom

  5. Marketing Milk Under Federal Orders in Texas. 

    E-Print Network [OSTI]

    Stelly, Randall

    1960-01-01

    in Corpus Christi and from 694 to :,1119 pounds in the Austin-Waco Market. By January 1, 1959, 76 federal milk market- .rp orders were operating throughout the United kites. About 40 percent of all the milk sold wholesale and more than one...

  6. IMPACT: Science goals and firsts with STEREO J.G. Luhmann a,*, D.W. Curtis a

    E-Print Network [OSTI]

    California at Berkeley, University of

    on the solar energetic particle, solar wind and suprathermal electron, and magnetic field measurements needed and multinational effort to provide the solar energetic particle (SEP), solar wind and suprathermal electronIMPACT: Science goals and firsts with STEREO J.G. Luhmann a,*, D.W. Curtis a , R.P. Lin a , D

  7. Les services de la PLM Mathrice Et quelques outils de web-confrence

    E-Print Network [OSTI]

    Jeanjean, Louis

    Les services de la PLM Mathrice Et quelques outils de web-conférence Richard Ferrere - Florent ensemble de services informatiques accessibles depuis tout l'internet. RF, FL, RP ()PLM et outils de web outils de web conférence Avril 2011 5 / 21 #12;Les services de la PLM (1) Services de la PLM Accès aux

  8. Cryptanalysis of S-DES Dr. K. S. Ooi

    E-Print Network [OSTI]

    International Association for Cryptologic Research (IACR)

    1.2 shows the total amount of financial losses caused by computer crime. Even with billions tools (see Figure 1.3). Figure 1.1 Source: 2000 CSI/FBI Computer Crime and Security Survey (from[RP00 Telecom fraud Financial fraus Virus Laptop Theft Insider net abuse Denial of service Sabotage System

  9. Quantitative and Qualitative Determination of Polysulfide Species in the Electrolyte of a Lithium-Sulfur Battery using HPLC ESI/MS with One-Step Derivatization

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zheng, Dong; Qu, Deyu; Yang, Xiao-Qing; Yu, Xiqian; Lee, Hung-Sui; Qu, Deyang

    2015-01-29

    The polysulfide species dissolved in aprotic solvents can be separated and analyzed by reverse phase (RP) high performance liquid chromatography (HPLC) in tandem with electrospray-mass spectroscopy. The relative distribution of polysulfide species in the electrolyte recovered from Li-S batteries is quantitatively and reliably determined for the first time.

  10. Reaction Pathways and Projection Operators: Application to String Methods

    E-Print Network [OSTI]

    Quapp, Wolfgang

    : Potential energy surface; reaction path; projected gradient; IRC; Newton trajectory; gradient extremal coordinate (IRC), for the following of the reduced gradient (RGF) or Newton trajectory (NT of the RP de#12;nition. We use here the IRC, 3 the distinguished or driven coordinate method 4

  11. Copyright 2004 by the Genetics Society of America DOI: 10.1534/genetics.104.032656

    E-Print Network [OSTI]

    Craig, Elizabeth A

    , heat shock, assembled from four rRNAs and 80 ribosomal proteins. oxidization, or osmotic stress, all and Biochemical Interactions Among Yar1, Ltv1 and RpS3 Define Novel Links Between Environmental Stress. In this study we show that two nonessential stress-responsive genes, YAR1 and LTV1, function in 40S subunit

  12. Texas Tech University Energy Savings Program October 2010 Update

    E-Print Network [OSTI]

    Zhuang, Yu

    Savings Electricity 49.11 48.27 Down 1.7% $ 91,300. Natural Gas 17.26 16.01 Down 7.2% $ 34,540. Steam 54, gasoline and natural gas. As a result of that order, Texas Tech University established the following goals Plan (Vehicles) In FY06, Governor Perry's Executive Order RP-49 required agencies to establish

  13. Energy Syst DOI 10.1007/s12667-009-0005-6

    E-Print Network [OSTI]

    Oren, Shmuel S.

    , or transmission element. R.P. O'Neill · E.A. Krall Federal Energy Regulatory Commission, Washington, DC 20426, USA commitment and transmission switching problem using duality concepts Richard P. O'Neill · Kory W. Hedman optimization models. Optimal transmission switching is a low cost way to leverage grid controllability: to make

  14. Baseline Risk Assessment for the F-Area Burning/Rubble Pits and Rubble Pit

    SciTech Connect (OSTI)

    Palmer, E.

    1996-03-01

    This document provides an overview of the Savannah River Site (SRS) and a description of the F-Area Burning/Rubble Pits (BRPs) and Rubble Pit (RP) unit. It also describes the objectives and scope of the baseline risk assessment (BRA).

  15. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Fluid Dynamics in Sucker Rod Pumps","Cutler, R.P.; Mansure, A.J.","1999-01-14T05:00:00Z",3261,,"SAND99-0093C","AC04-94AL85000","TRN: AH200112%%456","Conference",,,"Conference:...

  16. Assembling a viable, generic Risk-Based PV&T

    E-Print Network [OSTI]

    Das, Suman

    Based Methods, ASME PCC-3-2007. Risk-Based Inspection Technology, API RP 581, 2nd Edition, September Mitigation: Inspection Repair Replace Refer ASME PCC-3-2007, Fig. 3.3.4 #12;11/13/2014 5 The 6 step by NDE technicians, consider permanent labels, barcodes, QR codes etc. that correspond

  17. Monolithic RTD Array Oscillators at 100 GHz and 200 GHz with On-Wafer Bias Stabilization

    E-Print Network [OSTI]

    Rodwell, Mark J. W.

    .E. Muller and R.P. Smith Jet Propulsion Labs, Pasadena, CA 90265 We report 100 GHz and 200 GHz monolithic measurements of these are currently in progress. 712 GHz wave guide RTD oscillators have been demonstrated [1]. Power levels however are low due to constraints imposed on device area for suppressing parasitic bias

  18. Decision Fusion and Supervisor Synthesis in Decentralized Discrete-Event Systems

    E-Print Network [OSTI]

    Kwatny, Harry G.

    architecture, two or more supervisors simultaneously aect a DES plant. An excellent overview of the evolution by the NSF grant no. ECS-9216588 and the Electric Power Research Institute contract no. RP-8030 local controllable event set.) To date, virtually every study in decentralized supervisory control has

  19. RAMSEY DEGREES, LABELED AND UNLABELED PARTITIONS MIODRAG SOKIC

    E-Print Network [OSTI]

    Sokic, Miodrag

    RAMSEY DEGREES, LABELED AND UNLABELED PARTITIONS MIODRAG SOKI´C Abstract. Let K be a class.e. an equivalence relation, to structures in K. We calculate Ramsey degrees for structures in Kn and EK. In addition such that C ! (B)A r , then we say that K is a Ramsey class or that K satis...es the Ramsey property (RP

  20. Alfred Olivier Hero III gurriulum it

    E-Print Network [OSTI]

    Cafarella, Michael J.

    . . . . . . . . . . . . . . . . . . . . . . . . . RI 3.1.5 Book Reviews: . . . . . . . . . . . . . . . . . . . . . . . . . . RP 3.1.6 Technical Reports of Michigan courses taught . . . . . . . . . . . . . . . . RW 4.2 Post-doctoral students . . . . . . . . . . . . . . . . . . . . . . . . . RW 4.3 PhD students and thesis titles (University of Michigan) . . . . . SH 4.4 Major Short Courses

  1. MET 416: TROPICAL ANALYSIS AND FORECASTING Spring Semester 2013

    E-Print Network [OSTI]

    current (nowcasting) and expected weather, using all available real-time operational weather data Exam 4/9 Summer trade-wind weather based on HaRP 4/11-16 Large-scale influences, Diurnal cycle to the development of tropical storm systems and mesoscale weather. Lectures will include a forecasting perspective

  2. Interaction Between Cholesterol and Non-ionic Surfactants Studied by

    E-Print Network [OSTI]

    Miksik, Ivan

    -layer chromatography (RP-TLC) using cholesterol impregnated TLC plates and methanol­water mixtures as mobile phases. The RM values obtained were in linear correlation with the methanol concentration of the mobile phase that stacking interaction exists between cholesterol and the aromatic ring of the surfactants. The number

  3. Effect of Entropy Generation on the Performance of Humidification-Dehumidification Desalination Cycles

    E-Print Network [OSTI]

    Lienhard V, John H.

    power plant. In the developing world, the high cost of energy required for traditional desalination/s] Qin, Qsep heat input, heat of separation [kW] R specific gas constant [kJ/kg-K] Rp recovery ratio of electricity, and both MSF and MED require substantial heat input, usually as steam supplied by a neighboring

  4. Introduction Lyrics feature sets Experiments Conclusions and future work Combination of Audio &

    E-Print Network [OSTI]

    Rauber,Andreas

    to `traditional' bag-of-words · Compare to audio features · Rhythm Patterns (RP) · Rhythm Histograms (RHIntroduction Lyrics feature sets Experiments Conclusions and future work Combination of Audio & Lyrics Features for Genre Classication in Digital Audio Collections Rudolf Mayer, Andreas Rauber Vienna

  5. Quantitative and Qualitative Determination of Polysulfide Species in the Electrolyte of a Lithium-Sulfur Battery using HPLC ESI/MS with One-Step Derivatization

    SciTech Connect (OSTI)

    Zheng, Dong [Department of Chemistry; University of Massachusetts Boston; Boston MA 02125 USA; Qu, Deyu [Wuhan Univ. of Technology, Wuhan (China). Dept. of Chemistry; Yang, Xiao-Qing [Brookhaven National Lab. (BNL), Upton, NY (United States). Dept. of Chemistry; Yu, Xiqian [Brookhaven National Lab. (BNL), Upton, NY (United States). Dept. of Chemistry; Lee, Hung-Sui [Brookhaven National Lab. (BNL), Upton, NY (United States). Dept. of Chemistry; Qu, Deyang [Univ. of Massachusetts, Boston, MA (United States). Dept. of Chemistry

    2015-01-01

    The polysulfide species dissolved in aprotic solvents can be separated and analyzed by reverse phase (RP) high performance liquid chromatography (HPLC) in tandem with electrospray-mass spectroscopy. The relative distribution of polysulfide species in the electrolyte recovered from Li-S batteries is quantitatively and reliably determined for the first time.

  6. Khesbn no. 149 - Spring 2007 - Journal

    E-Print Network [OSTI]

    Admin, LAYCC

    2007-01-01

    ryrrf,.t rybrse:XbXu X - 0"l'l nx r1$1l? - Dl'Dl5t6r1 "lltrro'. 'tuuxs yu'rgllpr) nx i:*pi*ulrii:rru>rp lyDll fN .ly:Eyl ? '? ff lltly vtrnrrn nx uDNVJrb orD D'tt Fryn ybr /? t{

  7. Inferring distributions of chirodropid box-jellyfishes (Cnidaria: Cubozoa) in geographic and ecological space using ecological niche modeling

    E-Print Network [OSTI]

    Bentlage, Bastian; Peterson, A. Townsend; Cartwright, Paulyn

    2009-05-29

    : insights from predictive models. Glob Ecol Bio- geogr 11:131–141 Anderson RP, Lew D, Peterson AT (2003) Evaluating predic- tive models of species’ distributions: criteria for selecting optimal models. Ecol Model 162:211–232 Bahn V, McGill BJ (2007) Can...

  8. Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain

    E-Print Network [OSTI]

    Ahringe, Julie

    Femke Simmer1[ , Celine Moorman1[ , Alexander M. van der Linden1[ , Ewart Kuijk1 , Peter V. E. van den (Sijen et al. 2001; Simmer et al. 2002). There are four RdRP-like genes in C. elegans. Two of these, ego

  9. Safety Issues for Hg irradiation Experiment siting -

    E-Print Network [OSTI]

    McDonald, Kirk

    1 SC/RP Safety Issues for Hg irradiation Experiment siting - Activation of air and components water retention Activation of air by 40 pulses of 2E13 p corresponds to approx. 1 yr of operation in EHN1. Lack of beam dump leads to unnecessary activation of components and aggravates air activation #12

  10. Comparisons of numerical modelling of the Selective Laser Melting Laurent VAN BELLE1, 2, a

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    and arc additive layer manufacturing (WAALM), laser metal deposition (LMD), selective laser melting (SLM laser melting (SLM) first developed for rapid prototyping (RP) is now used for rapid manufacturing is based upon a double meshing with a multi step birth and death technique of manufactured part

  11. Determining Long-Term Performance of Cool Storage Systems from Short-Term Tests, Final Report 

    E-Print Network [OSTI]

    Reddy, T. A.; Elleson, J.; Haberl, J. S.

    2000-01-01

    This is the final report for ASHRAE Research Project 1004-RP: Determining Long-Term Performance of Cool Storage Systems from Short-Term Tests. This report presents the results of the development and application of the methodology to Case Study #2...

  12. Determining Long-Term Performance of Cool Storage Systems from Short-Term Tests, Progress Report, 6-99, Revised 12-99 

    E-Print Network [OSTI]

    Reddy, T. A.; Elleson, J.; Haberl, J. S.

    1999-01-01

    This is the Spring 1999 progress report on ASHRAE Research Project RP 1004: Determining Long-Term Performance of Cool Storage Systems from Short-Term Tests. This report presents an update concerning the work that has been accomplished since the June...

  13. Strategies for abbreviating multiple word titles 

    E-Print Network [OSTI]

    Takao, Alan Clay

    1993-01-01

    HLED [IHEDU i]HLTH I~ETEC IIFD'IC IIEDUI' ] ['f'CH [] ET I I EDTE 11. RECREATION AND PARKS I ] RP I I REPK f I RFCP I I RECR [ f RPKS i)REPA 12. SAFETY ENGINEER)NO [)SAFE IISENG IISEGR I[BE (] SAEN I I SFTY Figure A2. Encoding page (example) used...

  14. Lecture by John F. Nash Jr. An Interesting Equation

    E-Print Network [OSTI]

    Babu, G. Jogesh

    Lecture by John F. Nash Jr. An Interesting Equation The equation that we have discovered is a 4th order covariant tensor partial differential equation applicable to the metric tensor of a spaceRp a s b - 1 2 gab Rps = 0 And this equation is formally divergence free in the same way

  15. Renormalization in the Three-body Problem with Resonant P-wave Interactions

    E-Print Network [OSTI]

    Eric Braaten; P. Hagen; H. -W. Hammer; L. Platter

    2012-08-17

    Resonant P-wave interactions can be described by a minimal zero-range model defined by a truncated effective range expansion, so that the only 2-body interaction parameters are the inverse scattering volume 1/a_P and the P-wave effective range r_P. This minimal model can be formulated as a local quantum field theory with a P-wave interaction between atom fields and a molecular field. In the two-atom sector, the model is renormalizable, but it has unphysical behavior at high energies, because there are negative-probability states with momentum scale r_P. In the sector with three atoms, two of which are identical, renormalization in some parity and angular-momentum channels involves an ultraviolet limit cycle, indicating asymptotic discrete scale invariance. The Efimov effect occurs in the unitary limit a_P^(-1/3), r_P \\to 0, but this limit is unphysical because there are low-energy states with negative probability. The minimal model can be of physical relevance only at energies small compared to the energy scale set by r_P, where the effects of negative-probability states are suppressed.

  16. Book Review The Reaction Path in Chemistry: Current Ap-

    E-Print Network [OSTI]

    Quapp, Wolfgang

    . Heidrich, Editor, University of Leipzig, Germany; Kluwer, Dordrecht, Boston, London, 1995; 297 pp by the editor of the Z .present book: i analysis of potential energy sur- faces and calculation of chemically to the Nomenclature and Usage of the RP Concept'' written by the editor, D. Heidrich. In the following section, some

  17. Nonlinear ultimate strength analysis of fixed offshore platforms for earthquake environments

    SciTech Connect (OSTI)

    Chang, S.S. [Hudson Engineering Corp., Houston, TX (United States)

    1995-12-01

    The design of an offshore platform usually requires the use of ASME B31.3 and API (American Petroleum Institute) RP 2A design codes. ASME B31.3 addresses the design of pressure piping systems for offshore facilities while API RP 2A ``Recommended Practice for Planning, Designing and Constructing Fixed Offshore Platforms`` (WSD or LRFD) addresses the structural design. This paper first identifies the difference between the ASME B31.3 and API RP 2A on the earthquake load requirements. Second, the paper presents a nonlinear static pushover analysis of a typical fixed offshore platform subject to a ductility level earthquake in 394 ft (120 m) of water depth. The analysis uses a three-dimensional structural model consisting of STRUT, BEAM-COLUMN and LINEAR BEAM elements to determine the structural response while properly accounting for structure-pile-soil interaction effort. Finally, the status of current on-going efforts to implement the API RP 2A code (LRFD version) to the ISO code (International Organization for Standardization), particularly on the earthquake resistant design aspect of fixed offshore the platforms, is briefly reported.

  18. Fabrication/Assembly Instructions McMaster Parts List

    E-Print Network [OSTI]

    Dollar, Aaron M.

    ) ­ Model material: ABS ­ Support material? Yes · Not recommended to use PLA or alternative materials for RP parts · Majority of parts are designed to not require support material · Authors do not know how well be attached with any appropriately-sized set of bolts/nuts · Improved clinch knot used in prototype tests

  19. Design of linear multivariable systems with reduced sensitivity to parameter variations 

    E-Print Network [OSTI]

    Martin, Philippe Jean-Maurice

    1977-01-01

    of the adjoint matrix. Me then have the fol locating resul ts. dx, = (tr R (x, )) (R (&, , )*(dA + , 'dB}F)) ? (tr R (x, )) ((R?(~. )aF(~, I ? A + LI:) 1):. (dA + (d~)F) -(?Rp(v. ) ) (R~()(- j*((d~)I ) ) 3 2 J II-7 Remar ks (a) In this full...

  20. Gaseous and particulate contamination in space 

    E-Print Network [OSTI]

    Yang, Xiaofang

    1989-01-01

    ?w??effect on the NC'Ds is plotted for water at 300 km altitude in Fsgure 7. assuming that the observer is at the coordinates of (rpv, ? 0, rp, ? 1 m). YVhen the parameter Daway value is less than 0. 1 meter, the tangentsal or x-direction distance at which...

  1. The design and analysis of a thermal mass groundwater flowmeter 

    E-Print Network [OSTI]

    Weathers, Lenly Joseph

    1990-01-01

    in the Graetz problem is dT 24o dz RpV c (35a) or in dimensionless form: dd 4 dX Pe (356) The second snd third assumptions require modification of the numerical algorithm. Hence, the algorithm described in the previous section is used for flowmeter...

  2. Analytical Potential Energy Surface for the Na + HF NaF + H reaction: Application of Conventional Transition-State Theory

    E-Print Network [OSTI]

    Analytical Potential Energy Surface for the Na + HF NaF + H reaction: Application of Conventional Transition-State Theory Alessandra F. A. Vilela, Ricardo Gargano a Patr´icia R.P. Barreto b a Instituto de from calculation of the rate constant using con- ventional Transition State Theory (TST

  3. THIRD QUARTER 2006 www.sme.org/pcc VOL. 5, NO. 3 Latest-Generation SLA Resins Enable

    E-Print Network [OSTI]

    O'Brien, James F.

    and Smith [1] and Harris et al. [2-4]. The ability to fabricate injection molding tools directly from RP. In this research, a low-cost injection mold tool was directly fabricated from high-resolution stereolithography such as Z-Corp.'s 3-D printing have been studied in injection molding [7]. While direct tooling methods

  4. Recent Journal Articles on Current Research Professor Martha Mecartney

    E-Print Network [OSTI]

    Mease, Kenneth D.

    , zirconia composites Author(s): Dillon RP (Dillon, R. Peter)1 , Kim DK (Kim, Dong-Kyu)2 , Trujillo JE of zircon during high temperature deformation of zirconia-silica composites with alumina additions Author of a fine grain three-phase alumina-zirconia-mullite ceramic composite Author(s): Chen TD, Mecartney ML

  5. Soil and sedimentary charcoal evidence for Holocene forest fires in an inland

    E-Print Network [OSTI]

    Coxson, Darwyn

    University Way, Prince George BC V2N 4Z9, Canada; 2 Ministry of Forests and Range, 1011 Á/ 4th Avenue, Prince,3 (2006) pp. 415Á/427 # 2006 Edward Arnold (Publishers) Ltd 10.1191/0959683606hl937rp #12;combination

  6. Stat 586 Interpretation of Data I (Modern Applied Statistical Modeling and Computing)

    E-Print Network [OSTI]

    Xie, Minge

    , B.D., Modern Applied Statistics with S-Plus (Springer) Cody, R.P. and Simth, J.K. Applied Statistics and the SAS Programming Language Elliott, R. J. Learning SAS in the Computer Lab (Duxbury Press). Based allows) Students should expect to use either R or SAS or Splus statistical software packages in data

  7. International Oil and Gas Exploration and Development

    Reports and Publications (EIA)

    1993-01-01

    Presents country level data on oil reserves, oil production, active drilling rigs, seismic crews, wells drilled, oil reserve additions, and oil reserve to production ratios (R/P ratios) for about 85 countries, where available, from 1970 through 1991. World and regional summaries are given in both tabular and graphical form.

  8. The cross-coupled amplifier 

    E-Print Network [OSTI]

    Robinson, George Clyde

    1951-01-01

    p4 pa p4 rpa PE PZ Pb rp2 rPa = rpb As previously, define U', the per-cent unbalance of the , Ic?l- lr. . J I ~ . to~i output voltages E and E, by TJ= " ' (co= ' 100 ~E. , E-il l D. . . - Q?s, ) ()(Qd let E Ei, E& being sero. 'From Appendix AR...

  9. nature biotechnology VOLUME 29 NUMBER 8 AUGUST 2011 757 l e t t e r s

    E-Print Network [OSTI]

    Verkhusha, Vladislav V.

    the near-infrared optical window of high transparency1. Here we report a phytochrome-based near- infrared fluorescent. The RpBphP2-PAS-GAF/D202H variant was then subjected to three rounds of random mutagenesis followed by a round of saturat- ing mutagenesis of the identified key residues. The brightest clones

  10. SiO2 thickness determination by x-ray photoelectron spectroscopy, Auger electron spectroscopy, secondary ion mass spectrometry, Rutherford

    E-Print Network [OSTI]

    Florida, University of

    University, Uxbridge UB8 3PH, United Kingdom R. J. Bleiler Evans Texas, Round Rock, Texas 78681 K. Jones- creases in the projected range, Rp , of low energy ion im- plants. There are a number of analytical , nuclear reaction analysis NRA , and capacitance­voltage C­V measurements. In this study, we will compare

  11. GLOBAL VIRTUAL VAULT: PREVENTING UNAUTHORIZED PHYSICAL DISCLOSURE BY THE INSIDER Mike Fisk, Scott Miller, Alex Kent

    E-Print Network [OSTI]

    Fisk, Mike

    minimize this risk by con- centrating data storage and processing into a system of physically controlled to greatly reduce residual risk by limiting access to human-interaction protocols. This approach eliminates Laboratory under Contract No. DE-RP52-05NA25396 with the U.S. Department of Energy. The United States

  12. Incorporating Single-nucleotide Polymorphisms Into the Lyman Model to Improve Prediction of Radiation Pneumonitis

    SciTech Connect (OSTI)

    Tucker, Susan L., E-mail: sltucker@mdanderson.org [Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Li Minghuan [Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong (China)] [Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong (China); Xu Ting; Gomez, Daniel [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Yuan Xianglin [Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (China)] [Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (China); Yu Jinming [Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong (China)] [Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong (China); Liu Zhensheng; Yin Ming; Guan Xiaoxiang; Wang Lie; Wei Qingyi [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Vinogradskiy, Yevgeniy [University of Colorado School of Medicine, Aurora, Colorado (United States)] [University of Colorado School of Medicine, Aurora, Colorado (United States); Martel, Mary [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-01-01

    Purpose: To determine whether single-nucleotide polymorphisms (SNPs) in genes associated with DNA repair, cell cycle, transforming growth factor-{beta}, tumor necrosis factor and receptor, folic acid metabolism, and angiogenesis can significantly improve the fit of the Lyman-Kutcher-Burman (LKB) normal-tissue complication probability (NTCP) model of radiation pneumonitis (RP) risk among patients with non-small cell lung cancer (NSCLC). Methods and Materials: Sixteen SNPs from 10 different genes (XRCC1, XRCC3, APEX1, MDM2, TGF{beta}, TNF{alpha}, TNFR, MTHFR, MTRR, and VEGF) were genotyped in 141 NSCLC patients treated with definitive radiation therapy, with or without chemotherapy. The LKB model was used to estimate the risk of severe (grade {>=}3) RP as a function of mean lung dose (MLD), with SNPs and patient smoking status incorporated into the model as dose-modifying factors. Multivariate analyses were performed by adding significant factors to the MLD model in a forward stepwise procedure, with significance assessed using the likelihood-ratio test. Bootstrap analyses were used to assess the reproducibility of results under variations in the data. Results: Five SNPs were selected for inclusion in the multivariate NTCP model based on MLD alone. SNPs associated with an increased risk of severe RP were in genes for TGF{beta}, VEGF, TNF{alpha}, XRCC1 and APEX1. With smoking status included in the multivariate model, the SNPs significantly associated with increased risk of RP were in genes for TGF{beta}, VEGF, and XRCC3. Bootstrap analyses selected a median of 4 SNPs per model fit, with the 6 genes listed above selected most often. Conclusions: This study provides evidence that SNPs can significantly improve the predictive ability of the Lyman MLD model. With a small number of SNPs, it was possible to distinguish cohorts with >50% risk vs <10% risk of RP when they were exposed to high MLDs.

  13. In-vivo Performance of Photovoltaic Subretinal Prosthesis Yossi Mandel1,2

    E-Print Network [OSTI]

    Palanker, Daniel

    In-vivo Performance of Photovoltaic Subretinal Prosthesis Yossi Mandel1,2 , Georges Goetz1, University of Strathclyde, Glasgow, Scotland, G4 0NW ABSTRACT We have developed a photovoltaic retinal at 20 - 40 Hz. Modular design of the photovoltaic arrays allows scalability to a large number of pixels

  14. The time-rescaling interval model: extending conditional-intensity based models of neural spike trains Jonathan W. Pillow Depts. of Psychology & Neurobiology, The University of Texas at Austin

    E-Print Network [OSTI]

    Pillow, Jonathan

    . Acknowledgments 9. Conclusions · Conditional renewal (CR) process model incorporates real-time and rescaled dependencies between ISIs can also be modeled using conditional renewal densities 4. Time-rescaling theorem of conditional renewal model 8. Application to retinal data 7. Removing serial dependencies 2. Incorporating

  15. appropriately expressed the distinctive molec-ular markers of both the neural retina and the

    E-Print Network [OSTI]

    Levermann, Anders

    gravity wave -- a tsunami. MacAyeal et al. provide a theoretical analysis of the potential of iceberg, retinal progenitor cells -- the multi- potential cells of the neural retina -- divided and differentiated rules and internal forces within the epithelium. However, Eiraku and colleagues' power- ful in vitro

  16. Animal Learning & Behavior 2001, 29 (1), 1-9

    E-Print Network [OSTI]

    Cheng, Ken

    the beaconing trajectory, she may veer off on a sensori- motor vector toward the target location (Cheng, 1999b is asso- ciated with a particular (motor) trajectory to head to the target. Finally, on failing to see retinally, in terms of where they should appear on the retina. In order to dispense with having to translate

  17. Functional Ecology 2009, 23, 321329 doi: 10.1111/j.1365-2435.2008.01498.x 2008 The Authors. Journal compilation 2008 British Ecological Society

    E-Print Network [OSTI]

    McGraw, Kevin J.

    Functional Ecology 2009, 23, 321­329 doi: 10.1111/j.1365-2435.2008.01498.x © 2008 The Authors. Journal compilation © 2008 British Ecological Society Blackwell Publishing Ltd Seasonal, sexual, and quality related variation in retinal carotenoid accumulation in the house finch (Carpodacus mexicanus

  18. 1874 IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, VOL. 18, NO. 6, NOVEMBER 2014 Segmentation of the Blood Vessels and Optic Disk

    E-Print Network [OSTI]

    Li, Yongmin

    of the Blood Vessels and Optic Disk in Retinal Images Ana Salazar-Gonzalez, Djibril Kaba, Yongmin Li in modern ophthalmology. In this paper, we present a novel method to segment blood vessels and optic disk since the morphology of the blood vessel and the optic disk is an impor- tant indicator for diseases

  19. Plasticity of opsin gene expression in cichlids from Lake Malawi

    E-Print Network [OSTI]

    Carleton, Karen L.

    Plasticity of opsin gene expression in cichlids from Lake Malawi CHRISTOPHER M. HOFMANN, KELLY E. O plasticity has important evolutionary implications. In this study, we examined retinal plasticity in five found that the magnitude of plasticity varied across species. These findings have important implications

  20. Beata Jastrzebska Editor Methods and Protocols

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    ]. Then the spent chromophore was recycled back through the retinoid cycle to regenerate the photo- active" of cone pigments. The protonated Schiff base linkage of 11-cis-retinal with opsin [7, 10, 11] is critical but rods constitute about 80 % (or about 108 photo- receptor cells) of the cells in the human, mouse

  1. Modeling Measuring and Correcting the LCA of theModeling Measuring and Correcting the LCA of the Human EyeHuman Eye

    E-Print Network [OSTI]

    Ribak, Erez

    Modeling Measuring and Correcting the LCA of theModeling Measuring and Correcting the LCA aberration (LCA) and transverse chromatic aberration (TCA). In the presence of polychromatic light, these two types of chromatic aberrations have an impact on the retinal image. Studied isolated, both the LCA

  2. J. Phys. Chem. 1992, 96,737-745 737 Photochemical Hole-Burning Spectroscopy of Bovine Rhodopsin and Bacterlorhodopsln

    E-Print Network [OSTI]

    Boxer, Steven G.

    is a rapid isomerization of the retinal prosthetic group. Understanding the dynamics and structural changes their lowest energy electronic absorption bands. Hole widths were -2500 cm-' full width at half-maximum (fwhm-wavelengthdependence,vibronicfeatures, and widths of the observed holes. The calculations also yield the magnitudes of the homogeneous

  3. The role of PI3K in Ephrin-A1 induced cell retraction

    E-Print Network [OSTI]

    Fero, Daniel James

    2008-01-01

    Eng. 9 Suppl 1:S77-89. O'Leary, D.D. , and T. McLaughlin.retinal activity. Prog Brain Res. O'Leary, D.D. , and D.G.proper tissue development (O'Leary and Wilkinson, 1999) (

  4. C. Selected peer-reviewed publications (in chronological order.) (Publications selected from more than 350 peer-reviewed publications. The publications

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    C. Selected peer-reviewed publications (in chronological order.) (Publications selected from more than 350 peer-reviewed publications. The publications listed concern either the development of large of these MEA systems. The other ~300 publications are in the field of high energy physics.) 1. "The Retinal

  5. Infrared retina

    DOE Patents [OSTI]

    Krishna, Sanjay (Albuquerque, NM); Hayat, Majeed M. (Albuquerque, NM); Tyo, J. Scott (Tucson, AZ); Jang, Woo-Yong (Albuquerque, NM)

    2011-12-06

    Exemplary embodiments provide an infrared (IR) retinal system and method for making and using the IR retinal system. The IR retinal system can include adaptive sensor elements, whose properties including, e.g., spectral response, signal-to-noise ratio, polarization, or amplitude can be tailored at pixel level by changing the applied bias voltage across the detector. "Color" imagery can be obtained from the IR retinal system by using a single focal plane array. The IR sensor elements can be spectrally, spatially and temporally adaptive using quantum-confined transitions in nanoscale quantum dots. The IR sensor elements can be used as building blocks of an infrared retina, similar to cones of human retina, and can be designed to work in the long-wave infrared portion of the electromagnetic spectrum ranging from about 8 .mu.m to about 12 .mu.m as well as the mid-wave portion ranging from about 3 .mu.m to about 5 .mu.m.

  6. Robert E. Marc, PhD Calvin & JeNeal Hatch Presidential Endowed Chair in Ophthalmology

    E-Print Network [OSTI]

    Marc, Robert E.

    Robert E. Marc, PhD Calvin & JeNeal Hatch Presidential Endowed Chair in Ophthalmology Distinguished Lake City, UT 84132 801-585-6500 office, 801-587-7724 fax robert.marc@hsc.utah.edu http Neurochemistry of Retinal Circuits Marc, RE (PI) 01 Dec 11 ­ 30 Nov 16. Robert E. Marc, PI Aims: Generate

  7. Amino Acid Signatures in the Primate Retina Michael Kalloniatis,1 Robert E. Marc,2 and Ralph F. Murry2

    E-Print Network [OSTI]

    Marc, Robert E.

    Amino Acid Signatures in the Primate Retina Michael Kalloniatis,1 Robert E. Marc,2 and Ralph F glutamate, GABA, and glycine domi- nate retinal information processing (Yazulla, 1986; Ehinger, 1989; Marc, 1989; Marc et al., 1990, 1995; Massey, 1990; Davanger et al., 1991; Crooks and Kolb, 1992; Kalloniatis

  8. Bryan William Jones, Ph.D. Marc Laboratory

    E-Print Network [OSTI]

    Marc, Robert E.

    Bryan William Jones, Ph.D. Marc Laboratory John A. Moran Eye Center Dept. Ophthalmology University (IgG) library has been produced by the Marc Lab at the University of Utah, targeting over 60 types;MC signature collapse & recovery in Retinal Detachment Cat Retina (Marc, Murray, Fisher, Lindberg

  9. ROBERT E. MARC, PHD Distinguished Professor of Ophthalmology

    E-Print Network [OSTI]

    Marc, Robert E.

    ROBERT E. MARC, PHD Distinguished Professor of Ophthalmology University of Utah School of Medicine, Salt Lake City, UT 84132 robert.marc@hsc.utah.edu (801) 585-6500 EDUCATION 1971 BSc Honors, Univ Texas (Science, Nature, PNAS, PLoS Biology) SELECTED PUBLICATIONS Marc et al. 2012 Building retinal connectomes

  10. Robert E. Marc Moran Eye Center

    E-Print Network [OSTI]

    Marc, Robert E.

    #12;Robert E. Marc Moran Eye Center University of Utah Disclosure REM is a principal of Signature IN RETINAL NEUROANATOMY Marc RE 2010 Synaptic Organization of the retina. Adler's Physiology of the Eye 7(3): e1000074 Marc RE 2009 Functional Anatomy of the Retina. Duane's Foundations of Clinical

  11. 10/22/09 1:38 PMCaltech Scientists Create Robot Surrogate for Blind Persons in Testing Visual Prostheses -Caltech Page 1 of 3http://media.caltech.edu/press_releases/13294

    E-Print Network [OSTI]

    Arizona, University of

    artificial vision prostheses. And this, too, is often done. But it's a less-than-ideal solution since with a visual prosthesis, such as an artificial retina. An artificial retina consists of a silicon chip studded and Programs in Biomedicine. An artificial retina, also known as a retinal prosthesis, may use either

  12. Seeing differently... Optogenetics, holography, and vision restoration Lecturer: Inna Reutsky-Gefen

    E-Print Network [OSTI]

    Seeing differently... Optogenetics, holography, and vision restoration Lecturer: Inna Reutsky-electrode arrays might restore basic vision. Such implants electrically stimulate the retinal ganglion cells, just limitations. In this lecture I will present a non-invasive alternative to artificial stimulation

  13. Enhanced Photocurrent in Engineered Bacteriorhodopsin Monolayer Amol V. Patil,

    E-Print Network [OSTI]

    Watts, Anthony

    these membranes the protein is trimeric with each monomer, an independent proton pump composed of seven; the remaining steps are a sequence of thermal relaxations that return the retinal to its all-trans conformer.4 surface. Wild-type BR, which occurs as a two-dimensional crystal, exhibits exceptional thermal

  14. On the Foundations of Vision Modelling, IV. Weberized Mumford-Shah Model with Bose-Einstein Photon Noise: Light Adapted Segmentation

    E-Print Network [OSTI]

    Noise: Light Adapted Segmentation Inspired by Vision Psychology, Retinal Physiology, and Quantum are issues concerning why the classical Mumford-Shah model lacks light adaptivity, and why its "weberized. Numerical results further confirm and highlight the light adaptivity feature of the new model. Key words

  15. On the Foundations of Vision Modelling, IV. Weberized Mumford-Shah Model with Bose-Einstein Photon Noise: Light Adapted

    E-Print Network [OSTI]

    Ferguson, Thomas S.

    Noise: Light Adapted Segmentation Inspired by Vision Psychology, Retinal Physiology, and Quantum in details are issues concerning why the classical Mumford-Shah model lacks light adaptivity, and why its. Numerical results further con#12;rm and highlight the light adaptivity feature of the new model. Key words

  16. Temporal integration of focus position signal during compensation for pursuit in optic flow

    E-Print Network [OSTI]

    Krekelberg, Bart

    Temporal integration of focus position signal during compensation for pursuit in optic flow Center in optic flow that specifies heading. Concurrent smooth pursuit causes distortion of the retinal flow on optic flow perception has received little attention. Here we separated the effects of velocity and gaze

  17. Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons

    E-Print Network [OSTI]

    Kwok, Jessica C. F.; Yuen, Ying Lai; Lau, Wai Kit; Zhang, Fu Xing; Fawcett, James W.; Chan, Ying Shing; Shum, Daisy K. Y.

    2012-02-03

    showed that treatment of the fil- ter with ChABC resulted in cultures bearing longer neur- ites [19]. Treatment of chiasmatic brain slice cultures (E13 to E15, mouse) with ChABC resulted in misrouting of retinal ganglion cell projections at the optic...

  18. Type II Opsins: Evolutionary Origin by Internal Domain Duplication?

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    Science+Business Media, LLC 2008 Abstract Opsins are a large group of proteins with seven transmembrane evolutionary origin, in which both groups of opsins evolved a seven-TM structure and light sensitivity independently. This convergence may indicate an impor- tant role for seven-TM protein structure for retinal

  19. Motion and Color Analysis for Animat Perception Tamer F. Rabie and Demetri Terzopoulos

    E-Print Network [OSTI]

    Terzopoulos, Demetri

    . Spatially nonuniform retinal imaging providesopportunitiesfor increased compu- Figure 1: Artificial fishes 1979). Some species of fish are able to recognize the color signa- tures of other fish and use artificial fishes in a virtual marine world (Fig. 1). The fish animats are the result of research

  20. ORIGINAL PAPER Azobenzene photomechanics: prospects and potential

    E-Print Network [OSTI]

    Barrett, Christopher

    , the energy of the input photon amplified many thousands of times in the process. Complicated biochemical, hence direct application of the retinal/rhodopsin photo-switch to engineering systems is difficult of great interest for light energy harvesting applications across much of the solar spectrum, yet