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  1. Natural Fiber Composites: Retting, Preform Manufacture & Molding...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Natural Fiber Composites: Retting, Preform Manufacture & Molding Natural Fiber Composites: Retting, Preform Manufacture & Molding 2009 DOE Hydrogen Program and Vehicle Technologies...

  2. Natural Fiber Composites: Retting, Preform Manufacture & Molding...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Natural Fiber Composites: Retting, Preform Manufacture & Molding FY 2008 Progress Report for Lightweighting Materials - 8. Polymer Composites Research and Development FY 2009...

  3. Natural Fiber Composites: Retting, Preform Manufacture & Molding

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Retting, Preform Manufacture & Molding (Start:06.22.07) PI: Jim Holbery Presenter: Mark Smith Pacific Northwest National Laboratory Wednesday, February 27, 2008 This presentation...

  4. ret2dir: Rethinking Kernel Isolation Vasileios P. Kemerlis Michalis Polychronakis Angelos D. Keromytis

    E-Print Network [OSTI]

    Yang, Junfeng

    page frame sharing can be leveraged for the complete circumven- tion of software and hardware kernel, and kGuard. We also discuss techniques for constructing reliable ret2dir exploits against x86, x86-level software has become much harder, as recent versions of popular OSes come with nu- merous protections

  5. The Establishment of a Formal Midwest Renewable Energy Tracking System (M-RETS) Organization

    SciTech Connect (OSTI)

    Maria Redmond; Chela Bordas O'Connor

    2010-06-30

    The objectives identified in requesting and utilizing this funding has been met. The goal was to establish a formal, multi-jurisdictional organization to: (1) ensure the policy objectives of the participating jurisdictions are addressed through increased tradability of the Renewable Energy Credits (RECs) from M-RETS and to eliminate the possibility that a single jurisdiction will be the sole arbiter of the operation of the system; (2) facilitate the establishment of REC standards including the attributes related to, the creation, trading, and interaction with other trading and tracking systems; and (3) have a centralized and established organization that will be responsible for the contracting and governance responsibilities of a multi-jurisdictional tracking system. The M-RETS Inc. Board ensures that the system remains policy neutral; that the attributes of generation are tracked in a way that allows the system users to easily identify and trade relevant RECs; that the system can add jurisdictions as needed or desired; and that the tracking system operate in such a way to allow for the greatest access possible for those participating in other tracking or trading systems by allowing those systems to negotiate with a single M-RETS entity for the import and export of RECs. M-RETS as an organizational body participates and often leads the discussions related to the standardization of RECs and increasing the tradability of M-RETS RECs. M-RETS is a founding member of the Environmental Trading Network of North America (ETNNA) and continues to take a leadership role in the development of processes to facilitate trading among tracking systems and to standardize REC definitions. The Board of Directors of M-RETS, Inc., the non-profit corporation, continues to hold telephone/internet Board meetings. Legal counsel continues working with the board and APX management on a new agreement with APX. The board expects to have an agreement and corresponding fee structure in place by January 2011. The Board has recently approved exports to three other tracking systems and is in discussions about imports to the system. Below are the tasks outlined in the request and attached you will find the relevant documentation.

  6. Natural Fiber Composite Retting, Preform Manufacture and Molding (Project 18988/Agreement 16313)

    SciTech Connect (OSTI)

    Simmons, Kevin L.; Howe, Daniel T.; Laddha, Sachin; Fifield, Leonard S.

    2009-12-31

    Plant-based natural fibers can be used in place of glass in fiber reinforced automotive composites to reduce weight, cost and provide environmental benefits. Current automotive applications use natural fibers in injection molded thermoplastics for interior, non-structural applications. Compression molded natural fiber reinforced thermosets have the opportunity to extend natural fiber composite applications to structural and semi-structural parts and exterior parts realizing further vehicle weight savings. The development of low cost molding and fiber processing techniques for large volumes of natural fibers has helped in understanding the barriers of non-aqueous retting. The retting process has a significant effect on the fiber quality and its processing ability that is related to the natural fiber composite mechanical properties. PNNL has developed a compression molded fiber reinforced composite system of which is the basis for future preforming activities and fiber treatment. We are using this process to develop preforming techniques and to validate fiber treatment methods relative to OEM provided application specifications. It is anticipated for next fiscal year that demonstration of larger quantities of SMC materials and molding of larger, more complex components with a more complete testing regimen in coordination with Tier suppliers under OEM guidance.

  7. Research Experiences for Teachers, Site RET in Engineering: Connec7ng with Community Colleges Year 1 Isabel K. Lloyd & Leigh Abts

    E-Print Network [OSTI]

    Rubloff, Gary W.

    collaboraLve curriculum development seminar BENEFITS: · Increased student OUTCOMES: · Summer curriculum seminar key to translaLng research into relevantResearch Experiences for Teachers, Site RET in Engineering: Connec7ng

  8. Grant Title: RESEARCH EXPERIENCES FOR TEACHERS (RET) IN ENGINEERING AND COMPUTER Funding Opportunity Number: NSF 11-509. CFDA Number(s): 47.041.

    E-Print Network [OSTI]

    Farritor, Shane

    & Engineering. Area of Research: Engineering research to bring knowledge of engineering and technological science research in order to bring knowledge of engineering, computer science, and technologicalGrant Title: RESEARCH EXPERIENCES FOR TEACHERS (RET) IN ENGINEERING AND COMPUTER SCIENCE Funding

  9. Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy Department Under Secretary for Nuclear Security and Administrator for the National Nuclear Security Administration

    Office of Energy Efficiency and Renewable Energy (EERE)

    Lieutenant General Frank G. Klotz, United States Air Force (Ret), was confirmed by the Senate on Tuesday, April 08, 2014, as the Department of Energy’s Under Secretary for Nuclear Security and Administrator for the National Nuclear Security Administration (NNSA).

  10. Cold dust around nearby stars (DUNES). First results: A resolved exo-Kuiper belt around the solar-like star zeta^2 Ret

    E-Print Network [OSTI]

    Eiroa, C; Maldonado, J; González-García, B M; Rodmann, J; Heras, A M; Pilbratt, G L; Augereau, J -Ch; Mora, A; Montesinos, B; Ardila, D; Bryden, G; Liseau, R; Stapelfeldt, K; Launhardt, R; Solano, E; Bayo, A; Absil, O; Ar?evalo, M; Barrado, D; Beichmann, C; Danchi, W; del Burgo, C; Ertel, S; Fridlund, M; Fukagawa, M; Gutiérrez, R; Grün, E; Kamp, I; Krivov, A; Lebreton, J; Löhne, T; Lorente, R; Marshall, J; Martínez-Arnáiz, R; Meeus, G; Montes, D; Morbidelli, A; Müller, S; Mutschke, H; Nakagawa, T; Olofsson, G; Ribas, I; Roberge, A; Sanz-Forcada, J; Thébault, P; Walker, H; White, G J; Wolf, S

    2010-01-01

    We present the first far-IR observations of the solar-type stars delta Pav, HR 8501, 51 Peg and zeta^2 Ret, taken within the context of the DUNES Herschel Open Time Key Programme (OTKP). This project uses the PACS and SPIRE instruments with the objective of studying infrared excesses due to exo-Kuiper belts around nearby solar-type stars. The observed 100 um fluxes from delta Pav, HR 8501, and 51 Peg agree with the predicted photospheric fluxes, excluding debris disks brighter than Ldust/Lstar ~ 5 x 10^-7 (1 sigma level) around those stars. A flattened, disk-like structure with a semi-major axis of ~ 100 AU in size is detected around zeta^2 Ret. The resolved structure suggests the presence of an eccentric dust ring, which we interpret as an exo-Kuiper belt with Ldust/Lstar ~ 10^-5.

  11. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 3: Papers by Gen. Robert C. Richardson III (Ret.)

    SciTech Connect (OSTI)

    Rinne, R.L.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process-and how-would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies, or exercises. The conference proceedings consist of three volumes. Volume 1 contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and discussion panels. Volume 2 contains a short introduction and the papers and presentations from the conference. This volume contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.).

  12. Gen. Frank G. Klotz (Ret.)

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i nA Guide to Tapping intoandMinimaland the 1918 El NiñoDepartmentGeisha

  13. Automated Sky Search Max Doppke (RET)

    E-Print Network [OSTI]

    Cinabro, David

    of reliable software programs, a quality telescope, and a compatible CCD (charged coupling device) camera. My introductory period was spent working with the `SKY6' astronomy software by Software Bisque, Inc. This software an additional piece of software, called `Orchestrate'. Designed by #12;Software Bisque, it fully integrates

  14. Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the White House in the talks that led to the 2002 Moscow Treaty to reduce strategic nuclear weapons. Earlier in his career, he served as the defense attach at U.S. Embassy...

  15. Hon. Charles B. Swartwood, III (ret.) SPECIAL MASTER

    E-Print Network [OSTI]

    Department Office of Inspector General (OIG) to determine whether any of them involved conduct by NOAA Report and Recommendation to Secretary Locke concerning thirty (30) OIG designated cases. Secretary for resolving those complaints. The following is an interim report of my progress to date

  16. RetTrendReport1205.doc | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy BillsNo. 195 - Oct.7,Breakout SessionsEnergySampleWIPP

  17. Natural Fiber Composites: Retting, Preform Manufacture & Molding |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURING OFFICESpecialAPPENDIXConcentrating Solar PowerParksDepartment ofSecurity

  18. Renewable Energy Technologies Financial Model (RET Finance) | Open Energy

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EA EIS Report UrlNM-bRenewable Energy RFPsLtd RES Group Jump to:

  19. Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal GasAdministration Medal01 Sandia4) AugustA. -71- Particulate: ColumnsLake

  20. Lieutenant General Frank G. Klotz, USAF (Ret) | National Nuclear Security

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse Bergkamp GraduateResidentialLensless Imaging

  1. Design of a steady state thermal conductivity measurement device for CNT RET polymer composites

    E-Print Network [OSTI]

    Louie, Brian Ming

    2011-01-01

    conductive particles along with CNTs in polymer composites.polymer composites. 2,12 The combination of highly conductive

  2. Sensores CMOS para robotica e industria: Sensor ret nico espacio variante y vision activa

    E-Print Network [OSTI]

    Valencia, Universidad de

    imagenes con tecnolog a CMOS, son to- dav a conceptos poco conocidos en entornos industriales. En este art percepcion visiva, asemejandose cada vez mas a sus creadores. Por otro lado se presenta la tecnolog a CMOS. Por ultimo, se fun- den ambos conceptos y se presenta un sensor de imagenes, basado en tecnolog a CMOS

  3. Lieutenant General Frank G. Klotz, USAF (Ret) Sworn In as NNSA Administrator

    Broader source: Energy.gov [DOE]

    Secretary of Energy Ernest Moniz swore in Frank G. Klotz as the Department of Energy’s Undersecretary for Nuclear Security and NNSA Administrator.

  4. Lieutenant General Frank G. Klotz, USAF (Ret) Sworn In as NNSA

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal GasAdministration Medal01 Sandia4) AugustA. -71- Particulate: ColumnsLake MeadLead

  5. IAIFORIUA'IW3NPWCE!SSiNG LET MRS l(l971) 6%68.NORTH-HOLLAND PUBLISHING CY)@ANY Ret&ted 30 April 19' i

    E-Print Network [OSTI]

    Borodin, Allan

    (rP~). Thereffxe, an nth . c . polynomsal can be evaluated at fi porn;;; 141) operations,andatn pointsin

  6. Gallistel RET Model Instructions (4/15/03) Page 1 Instructions for Using the Excel Implementation of Rate Estimation Theory

    E-Print Network [OSTI]

    Pylyshyn, Zenon

    ) Check that it opened to the "Lng Model" sheet (look at sheet tabs at bottom left of workbook window the section below on "Interpreting Protocols." 5) To enter a ready-made protocol into the Lng Model, select it). Go back to Lng Model sheet, select the uppermost, leftmost input cell (Cell A3, which is grayed

  7. LCdr. Michael Shumberger, USN (ret), Dr. Andrew Duchowski, and Mr. Kevin Charlow Human Factors Engineering in Command, Control &

    E-Print Network [OSTI]

    Duchowski, Andrew T.

    , and security engineering functions in accordance with the Defense Acquisition System Directive, 5000.1 the processes and activities of international standard ISO/IEC 12207, Software Life-Cycle Processes Factors concepts, as they relate to software development are briefly reviewed with references to the ISO

  8. 2/24/2014 2014/02/23 MEMS @

    E-Print Network [OSTI]

    Chiao, Jung-Chih

    2/24/2014 2014/02/23 MEMS @ :: PIXNET :: http://spiderman186.pixnet.net/blog/post/103451560 1/3 Feb 23 Sun 2014 23:23 2014/02/23 MEMS 10Like 10 people like this. Sign Up to see what your friends like.Like micro-windmillsMEMS10 JC Chiao100 WinMEMS " " 1.8mm MEMS : BLOG 41 509893 (1) (18

  9. Current (as of March 21st): Faculty Research Description for HHMI RET Program 2011 Dr. Min-Ken Liao (Molecular Biology / Microbiology)

    E-Print Network [OSTI]

    antibiotic-resistance and heavy metal-resistance in urban stream bacteria. We will test for bacteria resistant to both antibiotics and heavy metals, and we will compare the abundance of such bacteria in urban bacteria and resistance genes. Briefly describe specific project(s) for your research intern. The main

  10. Greening the MLS for Business Intelligence

    Broader source: Energy.gov [DOE]

    Presents an exploration of the MLS platform, key RETS standards, current trends, and future expectations.

  11. SPORT F SHERY UNITED STATES DEPARTMENT OF THE INTERIOR

    E-Print Network [OSTI]

    pollution from sawdust disposal, ammonia, oil wells, gas works, and flax and hemp retting waste water

  12. Impact of imaging measurements on response assessment in glioblastoma clinical trials

    E-Print Network [OSTI]

    Reardon, DA; Ballman, KV; Buckner, JC; Chang, SM; Ellingson, BM

    2014-01-01

    13-cis-ret inoic acid and celecoxib in t he t reat m ent ofCis-retinoic acid + celecoxib Enzastaurin Erlotinib

  13. Klotz

    National Nuclear Security Administration (NNSA)

    5%2A en Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy Department Under Secretary for Nuclear Security and Administrator for the National Nuclear Security...

  14. The Effects of Resistance Exercise on In Vivo Cumulative Skeletal Muscle Protein Synthesis 

    E-Print Network [OSTI]

    Gasier, Heath G.

    2010-07-14

    An acute bout of resistance exercise (RE) and dietary protein consumption stimulate muscle protein synthesis (MPS). This anabolic effect is believed to be attenuated with resistance exercise training (RET), however, the mechanism for this plateau...

  15. Greening the MLS for Business Intelligence

    Broader source: Energy.gov [DOE]

    "Greening the MLS for Business Intelligence," by Margaret O’Sullivan, RealEstate Business Intelligence, July 10, 2012. Presents an exploration of the MLS platform, key RETS standards, current trends, and future expectations.

  16. Kelliher, Joseph From: Anderson, Margot

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    modules to form a sirgle, uriform glass pare Thvugh a ret- retenri arrngarent with Cetral Maine Powe; surplus solar electnaty is oqprted to the utility gnct effectivly spirug tde...

  17. Cost-effective allocation of public funding to promote the commercialization of renewable energy technology

    E-Print Network [OSTI]

    Culver, Lauren C. (Lauren Claire)

    2009-01-01

    The need for new Renewable Energy Technologies (RETs) is growing with the challenge of providing affordable electricity under increasing environmental and public health constraints while promoting energy security and ...

  18. Failure Mode, Effects and Criticality Analysis -Array D

    E-Print Network [OSTI]

    Rathbun, Julie A.

    , and have verified that Receivers A and B are failure isolated. This FMECA reflects the F ACI configuration 3 4 5 6 7 8 9 10 11 12 13 14... ·~:=.fRET DRAWING IN ACCORDANCE WITH STANDARDS PRESCRIBED

  19. CLEAN Webinar Series 2 | Open Energy Information

    Open Energy Info (EERE)

    JPG Triangle Right.JPG Webinar3.JPG Webinar4.JPG Webinar5.JPG Ret rieved from "http:en.openei.orgwindex.php?titleCLEANWebinarSeries2&oldid67800...

  20. Hydrogen Visual CDP Directory (Sunburst) | Open Energy Information

    Open Energy Info (EERE)

    Directory (Sunburst) Jump to: navigation, search Ret Left click to go straight to a CDP. Right click to find more information. The interactive graphic on this page links to all of...

  1. Widget:HydrogenSunburst | Open Energy Information

    Open Energy Info (EERE)

    Sunburst|width100%|height250px

    Example Ret Left click to go straight to a CDP. Right click to find more information. The interactive graphic on this page links to all of...

  2. CLEAN Webinar Series 4 | Open Energy Information

    Open Energy Info (EERE)

    WebinarHeader.JPG Webinar1.JPG Webinar2.JPG Webinar3.JPG Webinar4.JPG Triangle Right.JPG Webinar5.JPG Ret rieved from "http:en.openei.orgwindex.php?titleCLEANWebinarSeries4...

  3. CLEAN Webinar Series 1 | Open Energy Information

    Open Energy Info (EERE)

    WebinarHeader.JPG Webinar1.JPG Triangle Right.JPG Webinar2.JPG Webinar3.JPG Webinar4.JPG Webinar5.JPG Ret rieved from "http:en.openei.orgwindex.php?titleCLEANWebinarSeries...

  4. CLEAN Webinar Series 3 | Open Energy Information

    Open Energy Info (EERE)

    JPG Webinar3.JPG Triangle Right.JPG Webinar4.JPG Webinar5.JPG Ret rieved from "http:en.openei.orgwindex.php?titleCLEANWebinarSeries3&oldid678001...

  5. Development of High-Order CENO Finite-Volume Schemes with Block-Based Adaptive Mesh Refinement

    E-Print Network [OSTI]

    Groth, Clinton P. T.

    combinat¸ie cu un algoritm de adaptare a ret¸elei de discretizare bazat pe blocuri (AMR) este propusa, care este derivata pe baza unui ¸sablon centrat ¸si fixat de puncte, este combinata cu un algoritm de

  6. Senator Dorgan and Energy Under Secretary Orr to Speak at 2015...

    Office of Environmental Management (EM)

    - 3:32pm Addthis The U.S. Department of Energy's Vehicle Technologies Office (VTO) and Fuel Cell Technologies Office (FCTO) announce that Senator Byron L. Dorgan (ret.) and...

  7. Renewable Energy Research Laboratory University of Massachusetts, Amherst

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Renewable Energy Research Laboratory University of Massachusetts, Amherst 160 Governors Drive. Ellis February 28, 2008 #12;February 28, 2008 Renewable Energy Research Laboratory Page 1 University work sponsored by the Renewable Energy Trust (RET), as administered by the Massachusetts Technology

  8. Renewable Energy Research Laboratory University of Massachusetts, Amherst

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Renewable Energy Research Laboratory University of Massachusetts, Amherst 160 Governors Drive work sponsored by the Renewable Energy Trust (RET), as administered by the Massachusetts Technology 18, 2008 Renewable Energy Research Laboratory Page 1 University of Massachusetts, Amherst Amherst, MA

  9. Strategies for International Cooperation in Support of Energy Development in Pacific Island Nations

    SciTech Connect (OSTI)

    Miller, M.; Voss, P.; Warren, A.; Baring-Gould, I.; Conrad, M.

    2012-05-01

    The U.S. Department of Energy's National Renewable Energy Laboratory (NREL) has been partnering with island communities around the world to address the technical, policy, social, and economic hurdles to deploying energy efficiency and renewable energy technologies (RETs) on small, islanded systems. The lessons learned from these partnerships are briefly summarized in this document with the goal of supporting the International Renewable Energy Agency (IRENA) in the development of specific near-term and longer-term strategies for island RET deployment.

  10. Kinase Expression and Chromosomal Rearrangements in Papillary Thyroid Cancer Tissues: Investigations at the Molecular and Microscopic Levels

    SciTech Connect (OSTI)

    Weier, Heinz-Ulrich; Kwan, Johnson; Lu, Chun-Mei; Ito, Yuko; Wang, Mei; Baumgartner, Adolf; Hayward, Simon W.; Weier, Jingly F.; Zitzelsberger, Horst F.

    2009-07-07

    Structural chromosome aberrations are known hallmarks of many solid tumors. In the papillary form of thyroid cancer (PTC), for example, activation of the receptor tyrosine kinase (RTK) genes, ret or the neurotrophic tyrosine kinase receptor type I (NTRK1) by intra- or interchromosomal rearrangements have been suggested as a cause of the disease. The 1986 accident at the nuclear power plant in Chernobyl, USSR, led to the uncontrolled release of high levels of radioisotopes. Ten years later, the incidence of childhood papillary thyroid cancer (chPTC) near Chernobyl had risen by two orders of magnitude. Tumors removed from some of these patients showed aberrant expression of the ret RTK gene due to a ret/PTC1 or ret/PTC3 rearrangement involving chromosome 10. However, many cultured chPTC cells show a normal G-banded karyotype and no ret rearrangement. We hypothesize that the 'ret-negative' tumors inappropriately express a different oncogene or have lost function of a tumor suppressor as a result of chromosomal rearrangements, and decided to apply molecular and cytogenetic methods to search for potentially oncogenic chromosomal rearrangements in Chernobyl chPTC cases. Knowledge of the kind of genetic alterations may facilitate the early detection and staging of chPTC as well as provide guidance for therapeutic intervention.

  11. The Messed up Books (Pecha Trok Wa La). A personal recollection of Samten G. Karmay and the O rgyan chos gling catalogue (Bhutan)

    E-Print Network [OSTI]

    Pommaret, Françoise

    2008-01-01

    3. A short but steep walk of 45 minutes took him in full view of the grand mansion sitting at the top of a hillock and dominating the whole sTang valley. Buckwheat fields, pine trees and little hamlets were towered to the North by the cragged... stream_source_info ret_14_02.pdf.txt stream_content_type text/plain stream_size 14898 Content-Encoding UTF-8 stream_name ret_14_02.pdf.txt Content-Type text/plain; charset=UTF-8 "THE MESSED UP BOOKS" (PECHA TROK WA LA)1. A...

  12. International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009)

    E-Print Network [OSTI]

    Danon, Yaron

    2009-01-01

    International Conference on Mathematics, Computational Methods & Reactor Physics (M&C 2009) Saratoga Springs, New York, May 3-7, 2009, on CD-ROM, American Nuclear Society, LaGrange Park, IL (2009 and Nuclear Engineering Troy, New York, 12180 D.P. Barry, G. Leinweber, N.J. Drindak (ret.), J.G. Hoole Knolls

  13. Slaughter and carcass characteristics of finewool vs crossbred lambs 

    E-Print Network [OSTI]

    Bland, Bobby J

    1960-01-01

    Thichness of Ret Cser Loin Rye Caresse Credo Lan~ of Rody Iangth of Loin Carcass Kt. kvaesge Sadly Csin ~ 676es ~ 613ee ~ 631ee ~ 7SRee ~ 783es ~ 778ee . 3$6se . RCSac ~ 6LSse ~ 666se eS67eo ~ Sggse ~ 731eo ~ 633ek 64See ~ 666se...

  14. This document was downloaded on May 22, 2013 at 14:28:55 Author(s) Naval Postgraduate School (U.S.)

    E-Print Network [OSTI]

    , House of Representatives, Wash- ington, DC Lieutenant General Robert G. Gard, Jr., USA (Ret) Dr. Kermit Vice Admiral Robert L. Walters, Deputy Chief of Naval Operations (Surface Warfare), discusses O. Hanson, Dean, School and Graduate School of Business Administration, University of Washington Dr

  15. RESEARCH PAPER SERIES, 201314 14 MAY 2014 The Renewable Energy Target: a quick guide

    E-Print Network [OSTI]

    Green, Donna

    and solar hot water heaters. Liable entities have obligations to purchase renewable energy from both schemes: the large-scale RET (or LRET), for large renewable electricity developments like wind and solar farms, and the small-scale renewable energy scheme (the SRES) for small technology installations like rooftop solar

  16. CIMEL: Constructive and Collaborative, Inquiry-based Multimedia E-Learning (Summary of NSF CRCD Sponsored Grant #0087977 for October 2002 PI Meeting)

    E-Print Network [OSTI]

    Pottenger, William M.

    school teacher and two minority students from a local high school, joined the CIMEL team to assess and Cedar Crest College (a historically black and a women's college, respectively) as well as a RET middle to investigate adapting the multimedia for use in secondary schools. · A public interface at cimel

  17. Library Cell Layout with Alt-PSM Compliance and Composability Ke Cao, Puneet Dhawan and Jiang Hu

    E-Print Network [OSTI]

    Hu, Jiang

    Library Cell Layout with Alt-PSM Compliance and Composability Ke Cao, Puneet Dhawan and Jiang Hu and feasibility of deploying the RET such as Alternating Phase Shift- ing Mask (Alt-PSM) depend heavily on circuit that can achieve Alt- PSM compliance and composability in a constructive manner. Compared to previously

  18. clibrary.asm

    E-Print Network [OSTI]

    U: ANI 177Q CPI 'a' RM SUI 'a'-'A' RET .CPC: MOV C,A MVI B,0 LXI H,IOfcb DAD B DAD B MOV A,M MOV E,A INX H MOV D,M ORA D RNZ PUSH H LXI H,36 ...

  19. ANU Energy Change Institute Frank Fenner Building #141

    E-Print Network [OSTI]

    https://www.cleanenergycouncil.org.au/policy- advocacy/renewable-energy-target/ret-policy of 9 Review of the Renewable Energy Target Introduction The Energy Change Institute (ECI) at the Australian National University is pleased to provide a submission to the Review of the Renewable Energy

  20. Time Repor*ng Codes 3/1/15 TRC Description TRC Description TRC Description

    E-Print Network [OSTI]

    Barrash, Warren

    HHS Holiday Pay - Temp - Salary OTA Overtime Accrued 1.5 CBK Call Back Pay HLS Holiday Pay - Reg-Salary.0 CPT Comp Time Taken - Reg HOH Holiday Pay - Temp-Hourly REG Regular - Hourly/Salary DNO Organ Donation - Temp - Salary HOL Holiday Pay - Reg-Hourly RET Regular - Temp-Hourly/Salary DNR Organ Donation - Reg

  1. METODOS NUMERICOS EN INGENIERIA Y CIENCIAS APLICADAS E. O~nate, F. Zarate, G. Ayala, S. Botello y M. A. Moreles (Eds.)

    E-Print Network [OSTI]

    Bendito, Enrique

    M´ETODOS NUM´ERICOS EN INGENIER´IA Y CIENCIAS APLICADAS E. O~nate, F. Z´arate, G. Ayala, S. Botello INGENIER´IA Y CIENCIAS APLICADAS correspondiente coincide con los esquemas en diferencias sobre la ret´on relativamente simple, pre- sentaremos las definiciones de los operadores en diferencias en un con- texto

  2. Metodos combinatorios en teoria de juegos Introduccion

    E-Print Network [OSTI]

    Bilbao Arrese, Jesús Mario

    potencial de Hart y Mas-Colell. En el ret´iculo (L, ), el intervalo [S-, S] es un ´algebra de Boole para´ia convexa de partici´on, el intervalo [T, T+] es un ´algebra de Boole, para T L, T 6= , si

  3. A Quasi-Static Analysis of Dexterous Manipulation with Sliding and Rolling Contacts

    E-Print Network [OSTI]

    Trinkle, Jeff

    , especially when performed by an articulated mechanical hand. Kinematic analyses of dexterous manipulationA Quasi-Static Analysis of Dexterous Manipulation with Sliding and Rolling Contacts Je//ret; C of the manipulated object as functions of the robot's joint velocities. The inverse kinematic problem results

  4. Renewable Energy Research Laboratory University of Massachusetts, Amherst

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Renewable Energy Research Laboratory University of Massachusetts, Amherst 160 Governors Drive. Ellis July 14, 2008 #12;NOTICE AND ACKNOWLEDGEMENTS This report was prepared by the Renewable Energy sponsored by the Renewable Energy Trust (RET), as administered by the Massachusetts Technology Collaborative

  5. Renewable Energy Research Laboratory University of Massachusetts, Amherst

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Renewable Energy Research Laboratory University of Massachusetts, Amherst 160 Governors Drive by the Renewable Energy Research Laboratory (RERL) at the University of Massachusetts, Amherst in the course of performing work sponsored by the Renewable Energy Trust (RET), as administered by the Massachusetts

  6. Renewable Energy Research Laboratory University of Massachusetts, Amherst

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Renewable Energy Research Laboratory University of Massachusetts, Amherst 160 Governors Drive template version 3.1.2 #12;NOTICE AND ACKNOWLEDGEMENTS This report was prepared by the Renewable Energy sponsored by the Renewable Energy Trust (RET), as administered by the Massachusetts Technology Collaborative

  7. Renewable Energy Research Laboratory University of Massachusetts, Amherst

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Renewable Energy Research Laboratory University of Massachusetts, Amherst 160 Governors Drive AND ACKNOWLEDGEMENTS This report was prepared by the Renewable Energy Research Laboratory (RERL) at the University of Massachusetts, Amherst in the course of performing work sponsored by the Renewable Energy Trust (RET

  8. Renewable Energy Research Laboratory University of Massachusetts, Amherst

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Renewable Energy Research Laboratory University of Massachusetts, Amherst 160 Governors Drive Report template version 1.3 #12;April 3, 2006 Renewable Energy Research Laboratory Page 1 University work sponsored by the Renewable Energy Trust (RET), as administered by the Massachusetts Technology

  9. Renewable Energy Research Laboratory University of Massachusetts, Amherst

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Renewable Energy Research Laboratory University of Massachusetts, Amherst 160 Governors Drive. Ellis April 14, 2008 #12;NOTICE AND ACKNOWLEDGEMENTS This report was prepared by the Renewable Energy sponsored by the Renewable Energy Trust (RET), as administered by the Massachusetts Technology Collaborative

  10. A Science Servioe Feature 7 mTXES\\rEkTmR 7

    E-Print Network [OSTI]

    , cloud or rain that it codlains. Cold snow is d r y , only SSnilarly water vapor, a gas, is another dry University. WATER VAPOR There are three forms of water and only one of them is wet. Ice is a solid, perfectly dry until it begins t o melt and turn into water. melting snow is wet. there is nothing ret or dmnp

  11. H-Theorems in some kinetic models of chemically reacting dense gases

    E-Print Network [OSTI]

    Polewczak, Jacek

    gases: ­ search for the RET (Revised Enskog Theory) analog's of the reacting hard-sphere system ­ H as perturbations to the non-reactive terms. This was confirmed in a series of papers by B.Shizgal and M.Karplus (J by an equilibrium computations, where solvent effects enter through the free energy at the transition state. (for

  12. HTheorems in some kinetic models of chemically reacting dense gases

    E-Print Network [OSTI]

    Polewczak, Jacek

    gases: -- search for the RET (Revised Enskog Theory) analog's of the reacting hard­sphere system -- H as perturbations to the non­reactive terms. This was confirmed in a series of papers by B.Shizgal and M.Karplus (J by an equilibrium computations, where solvent e#ects enter through the free energy at the transition state. (for

  13. AN OPERATOR IS A PRODUCT OF TWO QUASI-NILPOTENT OPERATORS IFF IT IS NOT SEMI-FREDHOLM

    E-Print Network [OSTI]

    Müller, Vladimír

    AN OPERATOR IS A PRODUCT OF TWO QUASI-NILPOTENT OPERATORS IFF IT IS NOT SEMI-FREDHOLM ROMAN operators. The essential spectrum e(T), left essential spectrum le(T) and right essential spectrum re(T) of an operator T B(H) is defined as the spectrum, left spectrum and right spectrum of the class T + K

  14. National Oceanic and Atmospheric Administration Weather Bureau Hurricane Series

    E-Print Network [OSTI]

    #12;#12;National Oceanic and Atmospheric Administration Weather Bureau Hurricane Series ERRATA Beltsville, MD 20704-1387 November 6,2007 #12;YRKLXMINARY RET'OHT ON HURRICANE CLEO AUGUST 1.4-~9,1958 The existence af Hurricane "Cleo" i n the Atlantic som 900 milee e a ~ tof the Antflles (near 1 4 . 6 ~ ,47

  15. Chromosomal Rainbows detect Oncogenic Rearrangements of Signaling Molecules in Thyroid Tumors

    SciTech Connect (OSTI)

    O'Brien, Benjamin; Jossart, Gregg H.; Ito, Yuko; Greulich-Bode, Karin M.; Weier, Jingly F.; Munne, Santiago; Clark, Orlo H.; Weier, Heinz-Ulrich G.

    2010-08-19

    Altered signal transduction can be considered a hallmark of many solid tumors. In thyroid cancers the receptor tyrosine kinase (rtk) genes NTRK1 (Online Mendelian Inheritance in Man = OMIM *191315, also known as 'TRKA'), RET ('Rearranged during Transfection protooncogene', OMIM *164761) and MET (OMIM *164860) have been reported as activated, rearranged or overexpressed. In many cases, a combination of cytogenetic and molecular techniques allows elucidation of cellular changes that initiate tumor development and progression. While the mechanisms leading to overexpression of the rtk MET gene remain largely unknown, a variety of chromosomal rearrangements of the RET or NTKR1 gene could be demonstrated in thyroid cancer. Abnormal expressions in these tumors seem to follow a similar pattern: the rearrangement translocates the 3'-end of the rtk gene including the entire catalytic domain to an expressed gene leading to a chimeric RNA and protein with kinase activity. Our research was prompted by an increasing number of reports describing translocations involving ret and previously unknown translocation partners. We developed a high resolution technique based on fluorescence in situ hybridization (FISH) to allow rapid screening for cytogenetic rearrangements which complements conventional chromosome banding analysis. Our technique applies simultaneous hybridization of numerous probes labeled with different reporter molecules which are distributed along the target chromosome allowing the detection of cytogenetic changes at near megabase-pair (Mbp) resolution. Here, we report our results using a probe set specific for human chromosome 10, which is altered in a significant portion of human thyroid cancers (TC's). While rendering accurate information about the cytogenetic location of rearranged elements, our multi-locus, multi-color analysis was developed primarily to overcome limitations of whole chromosome painting (WCP) and chromosome banding techniques for fine mapping of breakpoints in papillary thyroid cancer (PTC).

  16. Cooking with Dry Beans (Spanish) 

    E-Print Network [OSTI]

    Anding, Jenna

    2008-12-09

    jalape?o (si gusta) sal (al gusto) Modo de preparaci?n 1. L?vese las manos y aseg?rese de que el sitio en que va a cocinar est? limpio. 2. Enjuague los frijoles con agua corriente. Elimine frijoles rotos, piedritas u otros... objetos que encuentre. 3. Remoje los frijoles: col?quelos en una cazuela grande. A?ada 5 tazas de agua por cada taza de frijoles. Haga hervir el agua con los frijoles y hi?rvalos durante dos minutos. Ret?relos del quemador, cubra la olla y d...

  17. Results of the Evaluation Study DeAL Decentralized Facade Integrated Ventilation Systems 

    E-Print Network [OSTI]

    Mahler, B.; Himmler, R.

    2008-01-01

    and 23.264 square metres in this project. The number of DVS devices ranges between 60 and 815 units per building. Floor - Supply Air (activ) - Heating - Cooling - Humidificati on 200 2007 6.114 m? Neckarsulm Parapet - Supply/Ret urn Air (activ...: 166200313Number of DVS: 200320022004Occupied since: 9.027 m?6.317 m?7.741 m?Area: BerlinZ?richZ?richLocation: Floor - Supply Air (passiv) -Heating -Cooling 2002 10.142 m? Hamburg Facade - Supply Air / Return Air (activ) -Heating - Cooling 815 2005 43...

  18. Comprehensive Energy Efficiency in the Process Industries 

    E-Print Network [OSTI]

    Rossiter, A.

    2015-01-01

    Efficiency in the Process Industries Alan Rossiter Rossiter & Associates alan@rossiters.org Beth Jones LyondellBasell (ret) ESL-IE-15-06-15a Proceedings of the Thrity-Seventh Industrial Energy Technology Conference New Orleans, LA. June 2-4, 2015 The Main.... June 2-4, 2015 Keys to Improvement •Behavioral changes ? people and organizations ? no-cost savings •Process improvements ? typically capital projects ESL-IE-15-06-15a Proceedings of the Thrity-Seventh Industrial Energy Technology Conference New Orleans...

  19. Imaginacion e identidad: los personajes de Juan Tovar 

    E-Print Network [OSTI]

    Dennis, Susan Michele

    1983-01-01

    imaginacibn EL MAR BAJO LA TIERRA: EL ARTE I IVA El ambiente Los personajes LA MUCHACHA EN EL BALCON 0 LA PRESENCIA D L R RET RAD : IPOS SI N ESP R TUAL 0 MA I A N P I FATA? Ambiguedades estilisticas y estructurales La encrucijada de dos vidas... propios impulsos y quedarse al margen de la corriente. Esta tesis sigue el estilo de Hispania. Entre estos estaba Juan Tovar. Tovar se considera "medio atipico" en su generacion, porque en sus libros la pre- sentacion de la adolescencia es escasa y muy...

  20. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 2: Papers and presentations

    SciTech Connect (OSTI)

    Rinne, R.L.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process -- and how -- would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies, or exercises. The conference proceedings consist of three volumes. Volume 1 contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and panels. This volume contains a short introduction and the papers and presentations from the conference. Volume 3 contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.). Individual papers in this volume were abstracted and indexed for the database.

  1. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 1, Introduction and summary

    SciTech Connect (OSTI)

    Rinne, R.L. [ed.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process -- and how -- would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies or exercise. The conference proceedings consist of three volumes. This volume, Volume 1, contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and discussion panels. Volume 2 contains a short introduction and the papers and presentations from the conference. Volume 3 contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.).

  2. Supplementary balance laws and the entropy principle

    E-Print Network [OSTI]

    Serge Preston

    2010-08-01

    In this work we study the mathematical aspects of the development in the continuum thermodynamics known as the "Entropy Principle". It started with the pioneering works of B.Coleman, W.Noll and I. Muller in 60th of XX cent. and got its further development mostly in the works of G. Boillat, I-Shis Liu and T.Ruggeri. "Entropy Principle" combines in itself the structural requirement on the form of balance laws of the thermodynamical system (denote such system $(\\mathcal{C})$) and on the entropy balance law with the convexity condition of the entropy density. First of these requirements has pure mathematical form defining so called "supplementary balance laws" (shortly SBL) associated with the original balance system. Vector space of SBL can be considered as a kind of natural "closure" of the original balance system. This space includes the original balance laws, the entropy balance, the balance laws corresponding to the symmetries of the balance system and some other balance equations. We consider the case of Rational Extended Thermodynamics where densities, fluxes and sources of the balance equations do not depend on the derivatives of physical fields $y^i$. We present the basic structures of RET: Lagrange-Liu equations,"main fields", and dual formulation of the balance system. We obtain and start studying the defining system of equations for the density $h^0$ of a supplementary balance law. This overdetermined linear system of PDE of second order determines all the densities $h^0$ and with them, due to the formalism of RET, the fluxes and sources of SBL. Solvability conditions of defining system delivers the constitutive restrictions on the balance equations of the original balance system. We illustrate our results by some simple examples of balance system and by describing all the supplementary balance laws and the constitutive restrictions for the Cattaneo heat propagation system.

  3. Cloud Properties and Radiative Heating Rates for TWP

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Comstock, Jennifer

    2013-11-07

    A cloud properties and radiative heating rates dataset is presented where cloud properties retrieved using lidar and radar observations are input into a radiative transfer model to compute radiative fluxes and heating rates at three ARM sites located in the Tropical Western Pacific (TWP) region. The cloud properties retrieval is a conditional retrieval that applies various retrieval techniques depending on the available data, that is if lidar, radar or both instruments detect cloud. This Combined Remote Sensor Retrieval Algorithm (CombRet) produces vertical profiles of liquid or ice water content (LWC or IWC), droplet effective radius (re), ice crystal generalized effective size (Dge), cloud phase, and cloud boundaries. The algorithm was compared with 3 other independent algorithms to help estimate the uncertainty in the cloud properties, fluxes, and heating rates (Comstock et al. 2013). The dataset is provided at 2 min temporal and 90 m vertical resolution. The current dataset is applied to time periods when the MMCR (Millimeter Cloud Radar) version of the ARSCL (Active Remotely-Sensed Cloud Locations) Value Added Product (VAP) is available. The MERGESONDE VAP is utilized where temperature and humidity profiles are required. Future additions to this dataset will utilize the new KAZR instrument and its associated VAPs.

  4. Environmental audit, Bonneville Power Administration, lower Columbia area

    SciTech Connect (OSTI)

    Not Available

    1990-11-01

    This report documents the results of the US Department of Energy's (DOE's) Environmental Audit conducted by the DOE Headquarters Office of Environmental Audit within the Bonneville Power Administration's (BPA's) Lower Columbia Area. The BPA facilities included in the Audit are the Ross Complex in Vancouver, Washington; the substations of North Bonneville, North Bonneville Annex, Camas, and Longview within the state of Washington; and the Acton and Troutdale Substations within the state of Oregon. The independent Audit was conducted by a team of professionals from DOE and contractors. The purpose of the Audit is to provide the Secretary of Energy, Admiral James D. Watkins, Ret., with the status of environmental programs within BPA's Lower Columbia Area. The Environmental Audit team identified 25 findings dealing with the lack of conformance with federal and state laws and regulations and DOE Orders, and 7 findings in which BMPs were not attained. Although all findings require corrective action, none required cessation of operations or reflect situations that present an immediate risk to public health or the environment. The Audit team noted inadequacies in PCB management included storage, labeling, reporting, and spill control. The most significant causal factors for the findings include lack of policy implementation throughout the Lower Columbia Area, inadequate training of personnel charged with environmental protection, lack of standard operating procedures for many programs, lack of reviews and appraisals, and an inaccurate perception of low risk for environmental concerns.

  5. The influence of TRP53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lemon, Jennifer A.; Taylor, Kristina; Verdecchia, Kyle; Phan, Nghi; Boreham, Douglas R.

    2014-01-01

    Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA double-strand breaks in bone marrow and genomic instability (MN-RET levels) in peripheral blood, between wild-type (Trp53+/+) and heterozygous (Trp53+/-) mice. The dose response for Trp53+/+ mice showed higher initial levelsmore »of radiation-induced lymphocyte apoptosis relative to Trp53+/- between 0 and 1 Gy. Although this trend was observed up to 12 hours post-irradiation, both genotypes ultimately reached the same level of apoptosis at 14 hours, suggesting the importance of late-onset p53-independent apoptotic responses in this mouse model. Expected radiation-induced G1 cell cycle delay was observed in Trp53+/+ but not Trp53+/-. Although p53 has an important role in cancer risk, we have shown its influence on radiation dose response can be temporally variable. This research highlights the importance of caution when using haematopoietic endpoints as surrogates to extrapolate radiation-induced cancer risk estimation.« less

  6. Effect of a relativistic correction to the Coulomb potential on the energy levels of hydrogen atom

    E-Print Network [OSTI]

    Behera, Harihar

    2012-01-01

    Based on classical electrodynamics, it is argued that the Coulomb potential (which is strictly valid for two point charges at rest), commonly used in the study of energy levels of hydrogen atom is not the correct one, because the electron in the hydrogen atom moves with relativistic speeds with respect to the nucleus. Retardation effect has to be considered in accordance with Li\\'{e}nard-Wiechert (or retarded) potential of a moving charge or the relativistic electrodynamics. However, such a consideration introduces a correction to the Coulomb potential, whose quantum mechanical expectation value is estimated at $E_{ret} = - \\frac{mc^2\\alpha ^4}{2n^3(l+1/2)}$, which is of the same order as the fine structure of hydrogen atom and hence added to the standard energy eigenvalue values of H-atom. This correction lifts the $l$-degeneracy in the spectra of H-atom and hence modifies the standard result. The result disturbs the existing agreement between the theory and experiments on H-atom and hence requires further t...

  7. Effect of a relativistic correction to the Coulomb potential on the energy levels of hydrogen atom

    E-Print Network [OSTI]

    Harihar Behera

    2012-01-10

    Based on classical electrodynamics, it is argued that the Coulomb potential (which is strictly valid for two point charges at rest), commonly used in the study of energy levels of hydrogen atom is not the correct one, because the electron in the hydrogen atom moves with relativistic speeds with respect to the nucleus. Retardation effect has to be considered in accordance with Li\\'{e}nard-Wiechert (or retarded) potential of a moving charge or the relativistic electrodynamics. However, such a consideration introduces a correction to the Coulomb potential, whose quantum mechanical expectation value is estimated at $E_{ret} = - \\frac{mc^2\\alpha ^4}{2n^3(l+1/2)}$, which is of the same order as the fine structure of hydrogen atom and hence added to the standard energy eigenvalue values of H-atom. This correction lifts the $l$-degeneracy in the spectra of H-atom and hence modifies the standard result. The result disturbs the existing agreement between the theory and experiments on H-atom and hence requires further theoretical and experimental re-examination. The implications of this result for the Kepler-problem in general is also discussed in the context of Heaviside's gravity, which seems to offer an alternative explanation for the non-Newtonian perihelion advance of Mercury without invoking the space-time curvature formalism of Einstein's general theory of relativity.

  8. Cloud Properties and Radiative Heating Rates for TWP

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Comstock, Jennifer

    A cloud properties and radiative heating rates dataset is presented where cloud properties retrieved using lidar and radar observations are input into a radiative transfer model to compute radiative fluxes and heating rates at three ARM sites located in the Tropical Western Pacific (TWP) region. The cloud properties retrieval is a conditional retrieval that applies various retrieval techniques depending on the available data, that is if lidar, radar or both instruments detect cloud. This Combined Remote Sensor Retrieval Algorithm (CombRet) produces vertical profiles of liquid or ice water content (LWC or IWC), droplet effective radius (re), ice crystal generalized effective size (Dge), cloud phase, and cloud boundaries. The algorithm was compared with 3 other independent algorithms to help estimate the uncertainty in the cloud properties, fluxes, and heating rates (Comstock et al. 2013). The dataset is provided at 2 min temporal and 90 m vertical resolution. The current dataset is applied to time periods when the MMCR (Millimeter Cloud Radar) version of the ARSCL (Active Remotely-Sensed Cloud Locations) Value Added Product (VAP) is available. The MERGESONDE VAP is utilized where temperature and humidity profiles are required. Future additions to this dataset will utilize the new KAZR instrument and its associated VAPs.

  9. The influence of TRP53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

    SciTech Connect (OSTI)

    Lemon, Jennifer A.; Taylor, Kristina; Verdecchia, Kyle; Phan, Nghi; Boreham, Douglas R.

    2014-01-01

    Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA double-strand breaks in bone marrow and genomic instability (MN-RET levels) in peripheral blood, between wild-type (Trp53+/+) and heterozygous (Trp53+/-) mice. The dose response for Trp53+/+ mice showed higher initial levels of radiation-induced lymphocyte apoptosis relative to Trp53+/- between 0 and 1 Gy. Although this trend was observed up to 12 hours post-irradiation, both genotypes ultimately reached the same level of apoptosis at 14 hours, suggesting the importance of late-onset p53-independent apoptotic responses in this mouse model. Expected radiation-induced G1 cell cycle delay was observed in Trp53+/+ but not Trp53+/-. Although p53 has an important role in cancer risk, we have shown its influence on radiation dose response can be temporally variable. This research highlights the importance of caution when using haematopoietic endpoints as surrogates to extrapolate radiation-induced cancer risk estimation.

  10. MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway

    SciTech Connect (OSTI)

    Ma, Yanfei; Qin, Huadong [Department of Fourth Surgery, the Second Affiliated Hospital of Harbin Medical University, 148 Xuefu Road, Nangang District, Harbin 150086 (China)] [Department of Fourth Surgery, the Second Affiliated Hospital of Harbin Medical University, 148 Xuefu Road, Nangang District, Harbin 150086 (China); Cui, Yunfu, E-mail: yfma77@126.com [Department of First Surgery, the Second Affiliated Hospital of Harbin Medical University, 148 Xuefu Road, Nangang District, Harbin 150086 (China)] [Department of First Surgery, the Second Affiliated Hospital of Harbin Medical University, 148 Xuefu Road, Nangang District, Harbin 150086 (China)

    2013-11-29

    Highlights: •MiR-34a is up- and GAS1 is down-regulated in papillary thyroid carcinoma. •GAS1 is a direct target for miR-34a. •MiR-34a promotes PTC cells proliferation and inhibits apoptosis through PI3K/Akt/Bad pathway. -- Abstract: MicroRNAs (miRNAs) are fundamental regulators of cell proliferation, differentiation, and apoptosis, and are implicated in tumorigenesis of many cancers. MiR-34a is best known as a tumor suppressor through repression of growth factors and oncogenes. Growth arrest specific1 (GAS1) protein is a tumor suppressor that inhibits cancer cell proliferation and induces apoptosis through inhibition of RET receptor tyrosine kinase. Both miR-34a and GAS1 are frequently down-regulated in various tumors. However, it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma (PTC), miR-34a is up-regulated in this specific type of cancer, although their potential roles in PTC tumorigenesis have not been examined to date. A computational search revealed that miR-34a putatively binds to the 3?-UTR of GAS1 gene. In the present study, we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues. Further studies indicated that GAS1 is directly targeted by miR-34a. Overexpression of miR-34a promoted PTC cell proliferation and colony formation and inhibited apoptosis, whereas knockdown of miR-34a showed the opposite effects. Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a. Furthermore, miR-34a overexpression led to activation of PI3K/Akt/Bad signaling pathway in PTC cells, and depletion of Akt reversed the pro-growth, anti-apoptotic effects of miR-34a. Taken together, our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway. MiR-34a functions as an oncogene in PTC.

  11. Irradiation-induced angiosarcoma and anti-angiogenic therapy: A therapeutic hope?

    SciTech Connect (OSTI)

    Azzariti, Amalia, E-mail: a.azzariti@oncologico.bari.it [Clinical and Preclinical Pharmacology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy); Porcelli, Letizia [Clinical and Preclinical Pharmacology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy); Mangia, Anita; Saponaro, Concetta [Functional Biomorphology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy); Quatrale, Anna E. [Clinical and Preclinical Pharmacology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy); Popescu, Ondina S. [Department of Pathology, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy); Strippoli, Sabino [Medical Oncology Unit, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy); Simone, Gianni [Department of Pathology, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy); Paradiso, Angelo [Experimental Medical Oncology, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy); Guida, Michele [Medical Oncology Unit, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, 70124 Bari (Italy)

    2014-02-15

    Angiosarcomas are rare soft-tissue sarcomas of endothelial cell origin. They can be sporadic or caused by therapeutic radiation, hence secondary breast angiosarcomas are an important subgroup of patients. Assessing the molecular biology of angiosarcomas and identify specific targets for treatment is challenging. There is currently great interest in the role of angiogenesis and of angiogenic factors associated with tumor pathogenesis and as targets for treatment of angiosarcomas. A primary cell line derived from a skin fragment of a irradiation-induced angiosarcoma patient was obtained and utilized to evaluate cell biomarkers CD31, CD34, HIF-1alpha and VEGFRs expression by immunocytochemistry and immunofluorescence, drugs cytotoxicity by cell counting and VEGF release by ELISA immunoassay. In addition to previous biomarkers, FVIII and VEGF were also evaluated on tumor specimens by immunohistochemistry to further confirm the diagnosis. We targeted the VEGF–VEGFR-2 axis of tumor angiogenesis with two different class of vascular targeted drugs; caprelsa, the VEGFR-2/EGFR/RET inhibitor and bevacizumab the anti-VEGF monoclonal antibody. We found the same biomarkers expression either in tumor specimens and in the cell line derived from tumor. In vitro experiments demonstrated that angiogenesis plays a pivotal role in the progression of this tumor as cells displayed high level of VEGFR-2, HIF-1 alpha strongly accumulated into the nucleus and the pro-angiogenic factor VEGF was released by cells in culture medium. The evaluation of caprelsa and bevacizumab cytotoxicity demonstrated that both drugs were effective in inhibiting tumor proliferation. Due to these results, we started to treat the patient with pazopanib, which was the unique tyrosine kinase inhibitor available in Italy through a compassionate supply program, obtaining a long lasting partial response. Our data suggest that the study of the primary cell line could help physicians in choosing a therapeutic approach for patient that almost in vitro shows chances of success and that the anti-angiogenetic agents are a reliable therapeutic opportunity for angiosarcomas patients. - Highlights: • Characterization of a new AS cell line for VEGFR-2, HIF-1 alpha and VEGF. • Caprelsa and bevacizumab inhibit AS cells proliferation. • Anti-angiogenetic agents as a reliable therapeutic opportunity for AS patients.