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  1. Renewable Energy Technologies Financial Model (RET Finance) ...

    Open Energy Info (EERE)

    Financial Model (RET Finance) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Renewable Energy Technologies Financial Model (RET Finance) Focus Area: Renewable Energy...

  2. RetTrendReport1205.doc | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    RetTrendReport1205.doc&0; PDF icon RetTrendReport1205.doc&0; More Documents & Publications Pension Plans for Contractor Workers April 1-10 comments.doc&0; POLICY GUIDANCE ...

  3. Lieutenant General Frank G. Klotz, USAF (Ret.) | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration Lieutenant General Frank G. Klotz, USAF (Ret.) Under Secretary for Nuclear Security and NNSA Administrator Our Leadership Lieutenant General Frank G. Klotz, United States Air Force (Ret.), was confirmed by the Senate on Tuesday, April 8, 2014, as the Department of Energy's Under Secretary for Nuclear Security and Administrator for the National Nuclear Security Administration (NNSA). As Under Secretary for Nuclear Security, Klotz is responsible for the management and operation

  4. Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy

    National Nuclear Security Administration (NNSA)

    Department Under Secretary for Nuclear Security and Administrator for the National Nuclear Security Administration | National Nuclear Security Administration , Confirmed as Energy Department Under Secretary for Nuclear Security and Administrator for the National Nuclear Security Administration April 08, 2014 WASHINGTON - Lieutenant General Frank G. Klotz, United States Air Force (Ret), was confirmed by the Senate on Tuesday, April 8, 2014, as the Department of Energy's Under Secretary for

  5. The Establishment of a Formal Midwest Renewable Energy Tracking System (M-RETS) Organization

    SciTech Connect (OSTI)

    Maria Redmond; Chela Bordas O'Connor

    2010-06-30

    The objectives identified in requesting and utilizing this funding has been met. The goal was to establish a formal, multi-jurisdictional organization to: (1) ensure the policy objectives of the participating jurisdictions are addressed through increased tradability of the Renewable Energy Credits (RECs) from M-RETS and to eliminate the possibility that a single jurisdiction will be the sole arbiter of the operation of the system; (2) facilitate the establishment of REC standards including the attributes related to, the creation, trading, and interaction with other trading and tracking systems; and (3) have a centralized and established organization that will be responsible for the contracting and governance responsibilities of a multi-jurisdictional tracking system. The M-RETS Inc. Board ensures that the system remains policy neutral; that the attributes of generation are tracked in a way that allows the system users to easily identify and trade relevant RECs; that the system can add jurisdictions as needed or desired; and that the tracking system operate in such a way to allow for the greatest access possible for those participating in other tracking or trading systems by allowing those systems to negotiate with a single M-RETS entity for the import and export of RECs. M-RETS as an organizational body participates and often leads the discussions related to the standardization of RECs and increasing the tradability of M-RETS RECs. M-RETS is a founding member of the Environmental Trading Network of North America (ETNNA) and continues to take a leadership role in the development of processes to facilitate trading among tracking systems and to standardize REC definitions. The Board of Directors of M-RETS, Inc., the non-profit corporation, continues to hold telephone/internet Board meetings. Legal counsel continues working with the board and APX management on a new agreement with APX. The board expects to have an agreement and corresponding fee structure in place by January 2011. The Board has recently approved exports to three other tracking systems and is in discussions about imports to the system. Below are the tasks outlined in the request and attached you will find the relevant documentation.

  6. Natural Fiber Composite Retting, Preform Manufacture and Molding (Project 18988/Agreement 16313)

    SciTech Connect (OSTI)

    Simmons, Kevin L.; Howe, Daniel T.; Laddha, Sachin; Fifield, Leonard S.

    2009-12-31

    Plant-based natural fibers can be used in place of glass in fiber reinforced automotive composites to reduce weight, cost and provide environmental benefits. Current automotive applications use natural fibers in injection molded thermoplastics for interior, non-structural applications. Compression molded natural fiber reinforced thermosets have the opportunity to extend natural fiber composite applications to structural and semi-structural parts and exterior parts realizing further vehicle weight savings. The development of low cost molding and fiber processing techniques for large volumes of natural fibers has helped in understanding the barriers of non-aqueous retting. The retting process has a significant effect on the fiber quality and its processing ability that is related to the natural fiber composite mechanical properties. PNNL has developed a compression molded fiber reinforced composite system of which is the basis for future preforming activities and fiber treatment. We are using this process to develop preforming techniques and to validate fiber treatment methods relative to OEM provided application specifications. It is anticipated for next fiscal year that demonstration of larger quantities of SMC materials and molding of larger, more complex components with a more complete testing regimen in coordination with Tier suppliers under OEM guidance.

  7. Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy Department Under Secretary for Nuclear Security and Administrator for the National Nuclear Security Administration

    Broader source: Energy.gov [DOE]

    Lieutenant General Frank G. Klotz, United States Air Force (Ret), was confirmed by the Senate on Tuesday, April 08, 2014, as the Department of Energy’s Under Secretary for Nuclear Security and Administrator for the National Nuclear Security Administration (NNSA).

  8. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 3: Papers by Gen. Robert C. Richardson III (Ret.)

    SciTech Connect (OSTI)

    Rinne, R.L.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process-and how-would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies, or exercises. The conference proceedings consist of three volumes. Volume 1 contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and discussion panels. Volume 2 contains a short introduction and the papers and presentations from the conference. This volume contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.).

  9. Gen. Frank G. Klotz (Ret.)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... logistical purposes, quality control and to have access to state-of-the-art techniques. ... In fact, Iran's history provides a good example. In February 2003, the IAEA requested ...

  10. Natural Fiber Composites: Retting, Preform Manufacture & Molding

    Broader source: Energy.gov [DOE]

    2009 DOE Hydrogen Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting, May 18-22, 2009 -- Washington D.C.

  11. Natural Fiber Composites: Retting, Preform Manufacture & Molding...

    Broader source: Energy.gov (indexed) [DOE]

    Review and Peer Evaluation Meeting, May 18-22, 2009 -- Washington D.C. PDF icon lm12smith.pdf More Documents & Publications FY 2009 Progress Report for Lightweighting Materials ...

  12. Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the White House in the talks that led to the 2002 Moscow Treaty to reduce strategic nuclear weapons. Earlier in his career, he served as the defense attach at U.S. Embassy...

  13. Lieutenant General Frank G. Klotz, USAF (Ret) Sworn In as NNSA Administrator

    Broader source: Energy.gov [DOE]

    Secretary of Energy Ernest Moniz swore in Frank G. Klotz as the Department of Energy’s Undersecretary for Nuclear Security and NNSA Administrator.

  14. Lieutenant General Frank G. Klotz, USAF (Ret) Sworn In as NNSA

    National Nuclear Security Administration (NNSA)

    Administrator | National Nuclear Security Administration Sworn In as NNSA Administrator April 17, 2014 WASHINGTON, D.C. - Secretary of Energy Ernest Moniz swore in Frank G. Klotz as the Department of Energy's Undersecretary for Nuclear Security and NNSA Administrator in a private ceremony this afternoon. General Klotz was joined by his wife, Nancy, and Acting Administrator Bruce Held. "I am very pleased that General Klotz has now been sworn in as the fourth Undersecretary of Nuclear

  15. Energy Storage Activities in the United States Electricity Grid...

    Energy Savers [EERE]

    Grid Electricity Advisory Committee Energy Storage Technologies Subcommittee Members ... Duncan General Manager (Ret.) Austin Energy Robert Gramlich Senior Vice President, ...

  16. Before the House Committee on Armed Services - Subcommittee on...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Before the House Committee on Armed Services - Subcommittee on Strategic Forces Testimony of Gen. Frank G. Klotz (Ret.) Before the House Committee on Armed Services - Subcommittee ...

  17. Electricity Advisory Committee

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Carlos Coe Millennium Energy Robert Curry Jr. CurryEnergy Clark Gellings Electric Power Research Institute Michael Heyeck American Electric Power (Ret.) Paul Hudson Stratus ...

  18. POLICY GUIDANCE MEMORANDUM #39 Phased Retirement | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Publications THE EMPLOYEE'S GUIDE TO BENEFITS FOR THOSE AFFECTED BY REDUCTION IN FORCE RetTrendReport1205.doc&0; Manager's Desk Reference on Human Capital Management Flexibilities

  19. Madelyn Creedon Confirmed as Principal Deputy Administrator for...

    Broader source: Energy.gov (indexed) [DOE]

    of Evansville, Evansville, Indiana. Addthis Related Articles Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy Department Under Secretary for Nuclear...

  20. Klotz

    National Nuclear Security Administration (NNSA)

    5%2A en Lieutenant General Frank G. Klotz, USAF (Ret), Confirmed as Energy Department Under Secretary for Nuclear Security and Administrator for the National Nuclear Security...

  1. Microsoft Word - Full report_cover page_colour pages.doc

    Open Energy Info (EERE)

    solar resource and a larger amount of electricity would be generated here from the same solar panel. At present, the share of Renewable Energy Technologies (RETs) in electricity...

  2. Genesys LLC | Open Energy Information

    Open Energy Info (EERE)

    search Name: Genesys LLC Place: Palo Alto, California Zip: 94306 Sector: Hydro, Hydrogen Product: Focused on RET (Radiant Energy Transfer) technology for the production of...

  3. Kansas City Field Office Mark Holecek Assoc. Admin. & Dep.

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Aoki NA-80 August 2015 Under Secretary for Nuclear Security & Administrator, NNSA Lt. Gen. Frank G. Klotz, USAF (Ret) Principal Deputy Administrator: Madelyn R. Creedon Deputy...

  4. Reversible Fuel Cells Workshop Summary Report | Department of Energy

    Office of Environmental Management (EM)

    RetTrendReport1205.doc� RetTrendReport1205.doc� PDF icon RetTrendReport1205.doc� More Documents & Publications Pension Plans for Contractor Workers April 1-10 comments.doc� POLICY GUIDANCE MEMORANDUM #39 Phased Retirement

    LBNL-1470E Retail Demand Response in Southwest Power Pool Ranjit Bharvirkar, Grayson Heffner and Charles Goldman Lawrence Berkeley National Laboratory Environmental Energy Technologies Division January 2009 The work described in this report

  5. Greening the MLS for Business Intelligence

    Broader source: Energy.gov [DOE]

    "Greening the MLS for Business Intelligence," by Margaret OSullivan, RealEstate Business Intelligence, July 10, 2012. Presents an exploration of the MLS platform, key RETS standards, current trends, and future expectations.

  6. Greening the MLS for Business Intelligence

    Broader source: Energy.gov [DOE]

    "Greening the MLS for Business Intelligence," by Margaret O’Sullivan, RealEstate Business Intelligence, July 10, 2012. Presents an exploration of the MLS platform, key RETS standards, current trends, and future expectations.

  7. Vikas Chandra ARM Research San Jose, CA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Strain CU wires PMOS LE, LE, < Strong RET FinFET LELE 14 Salishan Conference on High-Speed Computing, 2015 LE Future technology 2010 2015 2020 2025 2005 Complexity...

  8. ~txF74.ptx

    Energy Savers [EERE]

    WEDNESDAY OCTOBER 19, 2011 + + + + + The Electricity Advisory Committee met in the Conference Center of the National Rural Electric Cooperative Association Headquarters, 4301 Wilson Boulevard, Arlington, Virginia, at 2:00 p.m., Richard Cowart, Chair, presiding. MEMBERS PRESENT RICHARD COWART, Regulatory Assistance Project, Chair THE HONORABLE ROBERT CURRY, New York State Public Service Commission JOSE DELGADO, American Transmission Company (Ret.) ROGER DUNCAN, Austin Energy (Ret.) ROBERT

  9. U.S. Department of Energy Electricity Advisory Committee Meeting

    Energy Savers [EERE]

    Electricity Advisory Committee Meeting October 19 & 20th, 2011 Minutes EAC Members in Attendance: Richard Cowart Regulatory Assistance Project CHAIR Rick Bowen Alcoa Honorable Robert Curry New York State Public Service Commission Jose Delgado American Transmission Company (Ret.) Roger Duncan Austin Energy (Ret.) Robert Gramlich American Wind Energy Association Michael Heyeck American Electric Power Joseph Kelliher NextEra Energy, Inc. Edward Krapels Anbaric Holdings Ralph Masiello KEMA

  10. Strategies for International Cooperation in Support of Energy Development in Pacific Island Nations

    SciTech Connect (OSTI)

    Miller, M.; Voss, P.; Warren, A.; Baring-Gould, I.; Conrad, M.

    2012-05-01

    The U.S. Department of Energy's National Renewable Energy Laboratory (NREL) has been partnering with island communities around the world to address the technical, policy, social, and economic hurdles to deploying energy efficiency and renewable energy technologies (RETs) on small, islanded systems. The lessons learned from these partnerships are briefly summarized in this document with the goal of supporting the International Renewable Energy Agency (IRENA) in the development of specific near-term and longer-term strategies for island RET deployment.

  11. Stellar kinematics and metallicities in the ultra-faint dwarf galaxy Reticulum II

    SciTech Connect (OSTI)

    Simon, J. D.

    2015-07-23

    With this study, we present Magellan/M2FS, Very Large Telescope/GIRAFFE, and Gemini South/GMOS spectroscopy of the newly discovered Milky Way satellite Reticulum II. Based on the spectra of 25 Ret II member stars selected from Dark Energy Survey imaging, we measure a mean heliocentric velocity of $62.8\\pm 0.5\\;\\mathrm{km}\\;{{\\rm{s}}}^{-1}$ and a velocity dispersion of $3.3\\pm 0.7\\;\\mathrm{km}\\;{{\\rm{s}}}^{-1}$. The mass-to-light ratio of Ret II within its half-light radius is $470\\pm 210\\ {M}_{\\odot }/{L}_{\\odot }$, demonstrating that it is a strongly dark matter-dominated system. Despite its spatial proximity to the Magellanic Clouds, the radial velocity of Ret II differs from that of the LMC and SMC by 199 and 83 $\\mathrm{km}\\ {{\\rm{s}}}^{-1}$, respectively, suggesting that it is not gravitationally bound to the Magellanic system. The likely member stars of Ret II span 1.3 dex in metallicity, with a dispersion of 0.28 0.09 dex, and we identify several extremely metal-poor stars with ${\\rm{[Fe/H]}}\\lt -3$. In combination with its luminosity, size, and ellipticity, these results confirm that Ret II is an ultra-faint dwarf galaxy. With a mean metallicity of ${\\rm{[Fe/H]}}=-2.65\\pm 0.07$, Ret II matches Segue 1 as the most metal-poor galaxy known. Although Ret II is the third-closest dwarf galaxy to the Milky Way, the line-of-sight integral of the dark matter density squared is ${\\mathrm{log}}_{10}(J)=18.8\\pm 0.6\\;\\;\\mathrm{GeV}{\\;}^{2}\\;{\\mathrm{cm}}^{-5}\\;$ within 0fdg2, indicating that the predicted gamma-ray flux from dark matter annihilation in Ret II is lower than that of several other dwarf galaxies.

  12. NNSA Administrator honors nonproliferation research leader | National

    National Nuclear Security Administration (NNSA)

    Nuclear Security Administration Administrator honors nonproliferation research leader Monday, May 16, 2016 - 11:41am NNSA Administrator Lt. Gen. Frank G. Klotz (Ret.), right, presents the agency's Distinguished Service Gold Medal Award to Assistant Deputy Administrator for Nonproliferation Research and Development Dr. Rhys Williams. Last week DOE Under Secretary for Nuclear Security and NNSA Administrator Lt. Gen. Frank G. Klotz (Ret.) presented the agency's Assistant Deputy Administrator

  13. Kinase Expression and Chromosomal Rearrangements in Papillary Thyroid Cancer Tissues: Investigations at the Molecular and Microscopic Levels

    SciTech Connect (OSTI)

    Weier, Heinz-Ulrich; Kwan, Johnson; Lu, Chun-Mei; Ito, Yuko; Wang, Mei; Baumgartner, Adolf; Hayward, Simon W.; Weier, Jingly F.; Zitzelsberger, Horst F.

    2009-07-07

    Structural chromosome aberrations are known hallmarks of many solid tumors. In the papillary form of thyroid cancer (PTC), for example, activation of the receptor tyrosine kinase (RTK) genes, ret or the neurotrophic tyrosine kinase receptor type I (NTRK1) by intra- or interchromosomal rearrangements have been suggested as a cause of the disease. The 1986 accident at the nuclear power plant in Chernobyl, USSR, led to the uncontrolled release of high levels of radioisotopes. Ten years later, the incidence of childhood papillary thyroid cancer (chPTC) near Chernobyl had risen by two orders of magnitude. Tumors removed from some of these patients showed aberrant expression of the ret RTK gene due to a ret/PTC1 or ret/PTC3 rearrangement involving chromosome 10. However, many cultured chPTC cells show a normal G-banded karyotype and no ret rearrangement. We hypothesize that the 'ret-negative' tumors inappropriately express a different oncogene or have lost function of a tumor suppressor as a result of chromosomal rearrangements, and decided to apply molecular and cytogenetic methods to search for potentially oncogenic chromosomal rearrangements in Chernobyl chPTC cases. Knowledge of the kind of genetic alterations may facilitate the early detection and staging of chPTC as well as provide guidance for therapeutic intervention.

  14. Impact Evaluation Framework for Technology Deployment Programs: An Overview and Example

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    _______________________ An Overview and Example John H. Reed Innovologie LLC Gretchen Jordan Sandia National Laboratories Edward Vine Lawrence Berkeley National Laboratory July 2007 IMPACT EVALUATION FRAMEWORK FOR TECHNOLOGY DEPLOYMENT PROGRAMS An ap pro ach fo r q u anti fyi ng ret ro sp ect ive en erg y savin gs, cl ean en erg y ad van ces, an d m ark et eff ect s Introduction and Background The document briefly describes a framework for evaluating the "ret- rospective" impact of

  15. Stellar kinematics and metallicities in the ultra-faint dwarf galaxy Reticulum II

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Simon, J. D.

    2015-07-23

    With this study, we present Magellan/M2FS, Very Large Telescope/GIRAFFE, and Gemini South/GMOS spectroscopy of the newly discovered Milky Way satellite Reticulum II. Based on the spectra of 25 Ret II member stars selected from Dark Energy Survey imaging, we measure a mean heliocentric velocity ofmore » $$62.8\\pm 0.5\\;\\mathrm{km}\\;{{\\rm{s}}}^{-1}$$ and a velocity dispersion of $$3.3\\pm 0.7\\;\\mathrm{km}\\;{{\\rm{s}}}^{-1}$$. The mass-to-light ratio of Ret II within its half-light radius is $$470\\pm 210\\ {M}_{\\odot }/{L}_{\\odot }$$, demonstrating that it is a strongly dark matter-dominated system. Despite its spatial proximity to the Magellanic Clouds, the radial velocity of Ret II differs from that of the LMC and SMC by 199 and 83 $$\\mathrm{km}\\ {{\\rm{s}}}^{-1}$$, respectively, suggesting that it is not gravitationally bound to the Magellanic system. The likely member stars of Ret II span 1.3 dex in metallicity, with a dispersion of 0.28 ± 0.09 dex, and we identify several extremely metal-poor stars with $${\\rm{[Fe/H]}}\\lt -3$$. In combination with its luminosity, size, and ellipticity, these results confirm that Ret II is an ultra-faint dwarf galaxy. With a mean metallicity of $${\\rm{[Fe/H]}}=-2.65\\pm 0.07$$, Ret II matches Segue 1 as the most metal-poor galaxy known. Although Ret II is the third-closest dwarf galaxy to the Milky Way, the line-of-sight integral of the dark matter density squared is $${\\mathrm{log}}_{10}(J)=18.8\\pm 0.6\\;\\;\\mathrm{GeV}{\\;}^{2}\\;{\\mathrm{cm}}^{-5}\\;$$ within 0fdg2, indicating that the predicted gamma-ray flux from dark matter annihilation in Ret II is lower than that of several other dwarf galaxies.« less

  16. Senator Dorgan and Under Secretary Orr to Deliver Remarks at 2015 Fuel Cell Technologies and Vehicle Technologies Annual Merit Review

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy’s Fuel Cell Technologies Office and the Vehicle Technologies Office announce that Senator Byron L. Dorgan (ret.) and DOE’s Under Secretary for Science and Energy Franklin Orr will deliver remarks at the 2015 Hydrogen and Fuel Cell Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting on Monday, June 8.

  17. gold medal | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    gold medal NNSA Administrator honors nonproliferation research leader Last week DOE Under Secretary for Nuclear Security and NNSA Administrator Lt. Gen. Frank G. Klotz (Ret.) presented the agency's Assistant Deputy Administrator for Nonproliferation Research and Development (R&D) Dr. Rhys Williams with the Distinguished Service Gold Medal Award at a

  18. Energy Department Officially Dedicates New National Security Campus in Kansas City

    Broader source: Energy.gov [DOE]

    Secretary of Energy Ernest Moniz was joined by the Administrator of the National Nuclear Security Administration (NNSA), Lt. Gen. Frank Klotz, United States Air Force (Ret), U.S. Representatives Emanuel Cleaver II and Vicky Hartzler, and other local officials today to officially dedicate the new National Security Campus in Kansas City.

  19. Radiological Assistance Program | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Radiological Assistance Program NNSA Administrator visits Brookhaven National Laboratory On Friday, May 6, DOE Under Secretary for Nuclear Security and NNSA Administrator Lt. Gen. Frank G. Klotz (Ret.) visited Brookhaven National Laboratory in Upton, New York. Brookhaven Lab brings world-class facilities and expertise to the most exciting and important questions in basic and applied...

  20. nuclear counterterrorism | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    counterterrorism NNSA chief visits New Mexico laboratories NNSA Administrator Lt. Gen. Frank Klotz (Ret.) visited NNSA's New Mexico laboratories last week. At Sandia National Laboratories (SNL) and Los Alamos National Laboratory (LANL), Klotz addressed the workforces of both labs on how the FY17 budget request supports NNSA's missions, and he got a first-

  1. wind energy | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    wind energy NNSA chief visits New Mexico laboratories NNSA Administrator Lt. Gen. Frank Klotz (Ret.) visited NNSA's New Mexico laboratories last week. At Sandia National Laboratories (SNL) and Los Alamos National Laboratory (LANL), Klotz addressed the workforces of both labs on how the FY17 budget request supports NNSA's missions, and he got a first-... Pantex to Become Wind Energy Research Center

  2. Congress | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Congress NNSA administrator shows NM congressional delegation the Albuquerque Complex to make case for new facility WASHINGTON, DC - Lt. Gen. Frank Klotz (Ret.), Administrator of the Department of Energy's National Nuclear Security Administration, hosted two members of the New Mexico congressional delegation on Feb. 18 for a tour of the aging facilities occupied by 1,200 NNSA employees at the Albuquerque Complex

  3. Controlled dipole-dipole interactions between K Rydberg atoms in a laser-chopped effusive beam

    SciTech Connect (OSTI)

    Kutteruf, M. R.; Jones, R. R.

    2010-12-15

    We explore pulsed-field control of resonant dipole-dipole interactions between K Rydberg atoms. A laser-based atomic beam chopper is used to reduce the relative velocities of Rydberg atoms excited from an effusive thermal source. Resonant energy transfer (RET) between pairs of atoms is controlled via Stark tuning of the relevant Rydberg energy levels. Resonance line shapes in the electric field dependence of the RET probability are used to determine the effective temperature of the sample. We demonstrate that the relative atom velocities can be reduced to the point where the duration of the electric-field tuning pulses, and not the motion of neighboring atoms, defines the interaction time for each pair within the ensemble. Coherent, transform-limited broadening of the resonance line shape is observed as the tuning pulse duration is reduced below the natural time scale for collisions.

  4. Microsoft Word - Cover Page - Exhibit 12

    Energy Savers [EERE]

    2 Northern Pass Project List of Wetlands, Floodplains, Streams and Threatened and Endangered Wildlife and Plants Potentially Present on Proposed Route P:\Bedford Projects\Projects\21812.200 Northern Pass HVDC RET\Natural Resources Report\Report Section Docs\Wetlands, Vernal Pools, Streams\Wetland Tables\Wetland_Table_Combined(2-13-13).Docx 1 Exhibit 12: Existing ROW Wetland Summary Table - North, Central and South Sections (North Section South of Lost Nation Substation) Wetland Functions and

  5. Before the House Committee on Armed Services - Subcommittee on Strategic

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Forces | Department of Energy Armed Services - Subcommittee on Strategic Forces Before the House Committee on Armed Services - Subcommittee on Strategic Forces Testimony of Gen. Frank G. Klotz (Ret.) Before the House Committee on Armed Services - Subcommittee on Strategic Forces PDF icon 9-10-15_Frank_Klotz FT HAS.pdf More Documents & Publications Before the House Committee on Foreign Affairs Before the Senate Committee on Armed Services Before the Senate Foreign Affairs Committee

  6. Senator Dorgan and Energy Under Secretary Orr to Speak at 2015 Annual Merit

    Energy Savers [EERE]

    Review Plenary Session | Department of Energy Senator Dorgan and Energy Under Secretary Orr to Speak at 2015 Annual Merit Review Plenary Session Senator Dorgan and Energy Under Secretary Orr to Speak at 2015 Annual Merit Review Plenary Session June 4, 2015 - 3:32pm Addthis The U.S. Department of Energy's Vehicle Technologies Office (VTO) and Fuel Cell Technologies Office (FCTO) announce that Senator Byron L. Dorgan (ret.) and DOE's Under Secretary for Science and Energy Franklin Orr will

  7. Electronic Structure and Excited State Dynamics in Biological and Nanoscale

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems | MIT-Harvard Center for Excitonics Electronic Structure and Excited State Dynamics in Biological and Nanoscale Systems February 25, 2009 at 3pm/36-428 Gregory D. Scholes Department of Chemistry, University of Toronto scholes2 abstract: After photoexcitation, energy absorbed by a molecule can be transferred efficiently over a distance of up to several tens of Ångstrom to another molecule by the process of resonance energy transfer, RET (also commonly known as electronic energy

  8. Senator Dorgan and Acting Assistant Secretary Friedman at 2016 Fuel Cell Technologies and Vehicle Technologies Annual Merit Review

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy’s (DOE's) Fuel Cell Technologies Office and the Vehicle Technologies Office announce that Senator Byron L. Dorgan (ret.) and DOE’s Acting Assistant Secretary for the Office of Energy Efficiency and Renewable Energy, David Friedman, will deliver remarks at the 2016 Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting on Monday, June 6.

  9. Pantex Wind Farm Complete | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Library / Press Releases Pantex Wind Farm Complete June 18, 2014 Lt. Gen. (Ret.) Frank G. Klotz, Under Secretary for Nuclear Security and Administrator for the National Nuclear Security Administration (NNSA), dedicated the nation's largest federally owned wind farm Tuesday at the Pantex Plant near Amarillo, Texas. Klotz was joined at the ceremony by Kevin Knobloch, DOE's Chief of Staff, NNSA Production Office (NPO) Manager Steven Erhart, Siemens Government Technologies President and CEO Judy

  10. recommissioning

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    rap NNSA Administrator visits Brookhaven National Laboratory On Friday, May 6, DOE Under Secretary for Nuclear Security and NNSA Administrator Lt. Gen. Frank G. Klotz (Ret.) visited Brookhaven National Laboratory in Upton, New York. Brookhaven Lab brings world-class facilities and expertise to the most exciting and important questions in basic and applied... Nation's Radiological Assistance Program teams practice emergency response Radiological Assistance Program (RAP) teams from around the

  11. Microsoft PowerPoint - Vic.Reis.Salishan.09

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Potential Roles for High Performance Computing in the Obama Administration 2009 Conference on High Speed Computing Victor Reis Senior Advisor Department of Energy Alex Larzelere Lt. USCG(Ret) Department of Energy & With Specific Emphasis on DOE Outline * The Obama Administration Views on HPC - From White House Website * A very short history of U.S. High Performance Computing - The role of computer architecture * A short history of ASCI - Lessons Learned * Problem & Partnership drives the

  12. NNSA Administrator visits Brookhaven National Laboratory | National Nuclear

    National Nuclear Security Administration (NNSA)

    Security Administration NNSA Administrator visits Brookhaven National Laboratory Tuesday, May 10, 2016 - 9:37am On Friday, May 6, DOE Under Secretary for Nuclear Security and NNSA Administrator Lt. Gen. Frank G. Klotz (Ret.) visited Brookhaven National Laboratory in Upton, New York. Brookhaven Lab brings world-class facilities and expertise to the most exciting and important questions in basic and applied science-from the birth of the universe to the sustainable energy technology of

  13. NNSA administrator shows NM congressional delegation the Albuquerque

    National Nuclear Security Administration (NNSA)

    Complex to make case for new facility | National Nuclear Security Administration NNSA administrator shows NM congressional delegation the Albuquerque Complex to make case for new facility Friday, February 26, 2016 - 1:42pm WASHINGTON, DC - Lt. Gen. Frank Klotz (Ret.), Administrator of the Department of Energy's National Nuclear Security Administration, hosted two members of the New Mexico congressional delegation on Feb. 18 for a tour of the aging facilities occupied by 1,200 NNSA employees

  14. Podcast: Pushing the Limits of Solar Cells | MIT-Harvard Center for

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Plutonium NNSA chief visits New Mexico laboratories NNSA Administrator Lt. Gen. Frank Klotz (Ret.) visited NNSA's New Mexico laboratories last week. At Sandia National Laboratories (SNL) and Los Alamos National Laboratory (LANL), Klotz addressed the workforces of both labs on how the FY17 budget request supports NNSA's missions, and he got a first-... United States Collaborates with Switzerland to Remove Last Remaining Separated Plutonium (WASHINGTON, D.C.) - The Department of Energy's National

  15. February 2016 | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    February 2016 NNSA administrator shows NM congressional delegation the Albuquerque Complex to make case for new facility Friday, February 26, 2016 - 1:42pm WASHINGTON, DC - Lt. Gen. Frank Klotz (Ret.), Administrator of the Department of Energy's National Nuclear Security Administration, hosted two members of the New Mexico congressional delegation on Feb. 18 for a tour of the aging facilities occupied by 1,200 NNSA employees at the Albuquerque Complex on Kirtland Air Force Base in New Mexico.

  16. Part III - List of Documents, Exhibits, and Other Attachments

    National Nuclear Security Administration (NNSA)

    D KEY PERSONNEL TITLE NAME Laboratory Director George Miller, Ph.D Deputy Director Steven Liedle, D. Env. Laboratory Counsel Melissa Allain, J.D. Associate Director, Facilities and Infrastructure Harold Conner, Jr. Associate Director, Computation and Simulation Dona Crawford Associate Director, Chemistry, Materials, and Life Sciences Tomás Díaz de la Rubia, Ph.D. Principal Associate Director, Global Security John Doesburg, Major General (Ret.) Associate Director, Physical Sciences William

  17. wind | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    wind Wind farm generating more renewable energy than expected for Pantex The Texas Panhandle has some of the world's best winds for creating renewable energy, and the Wind Farm at the Pantex Plant is taking advantage of those winds, generating up to 60% of the energy needs of the plant in an inaugural program, mandated by the White House. Back in 2013,... NNSA chief visits New Mexico laboratories NNSA Administrator Lt. Gen. Frank Klotz (Ret.) visited NNSA's New Mexico laboratories last week. At

  18. workforce | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    workforce NNSA administrator shows NM congressional delegation the Albuquerque Complex to make case for new facility WASHINGTON, DC - Lt. Gen. Frank Klotz (Ret.), Administrator of the Department of Energy's National Nuclear Security Administration, hosted two members of the New Mexico congressional delegation on Feb. 18 for a tour of the aging facilities occupied by 1,200 NNSA employees at the Albuquerque Complex... DOE Celebrates LGBT Pride Month To recognize the accomplishments of Lesbian,

  19. Renewable energy and its potential for carbon emissions reductions in developing countries: Methodology for technology evaluation. Case study application to Mexico

    SciTech Connect (OSTI)

    Corbus, D.; Martinez, M.; Rodriguez, L.; Mark, J.

    1994-08-01

    Many projects have been proposed to promote and demonstrate renewable energy technologies (RETs) in developing countries on the basis of their potential to reduce carbon emissions. However, no uniform methodology has been developed for evaluating RETs in terms of their future carbon emissions reduction potential. This study outlines a methodology for identifying RETs that have the potential for achieving large carbon emissions reductions in the future, while also meeting key criteria for commercialization and acceptability in developing countries. In addition, this study evaluates the connection between technology identification and the selection of projects that are designed to demonstrate technologies with a propensity for carbon emission reductions (e.g., Global Environmental Facility projects). Although this report applies the methodology to Mexico in a case study format, the methodology is broad based and could be applied to any developing country, as well as to other technologies. The methodology used in this report is composed of four steps: technology screening, technology identification, technology deployment scenarios, and estimates of carbon emissions reductions. The four technologies with the highest ranking in the technology identification process for the on-grid category were geothermal, biomass cogeneration, wind, and micro-/mini-hydro. Compressed natural gas (CNG) was the alternative that received the highest ranking for the transportation category.

  20. Chromosomal Rainbows detect Oncogenic Rearrangements of Signaling Molecules in Thyroid Tumors

    SciTech Connect (OSTI)

    O'Brien, Benjamin; Jossart, Gregg H.; Ito, Yuko; Greulich-Bode, Karin M.; Weier, Jingly F.; Munne, Santiago; Clark, Orlo H.; Weier, Heinz-Ulrich G.

    2010-08-19

    Altered signal transduction can be considered a hallmark of many solid tumors. In thyroid cancers the receptor tyrosine kinase (rtk) genes NTRK1 (Online Mendelian Inheritance in Man = OMIM *191315, also known as 'TRKA'), RET ('Rearranged during Transfection protooncogene', OMIM *164761) and MET (OMIM *164860) have been reported as activated, rearranged or overexpressed. In many cases, a combination of cytogenetic and molecular techniques allows elucidation of cellular changes that initiate tumor development and progression. While the mechanisms leading to overexpression of the rtk MET gene remain largely unknown, a variety of chromosomal rearrangements of the RET or NTKR1 gene could be demonstrated in thyroid cancer. Abnormal expressions in these tumors seem to follow a similar pattern: the rearrangement translocates the 3'-end of the rtk gene including the entire catalytic domain to an expressed gene leading to a chimeric RNA and protein with kinase activity. Our research was prompted by an increasing number of reports describing translocations involving ret and previously unknown translocation partners. We developed a high resolution technique based on fluorescence in situ hybridization (FISH) to allow rapid screening for cytogenetic rearrangements which complements conventional chromosome banding analysis. Our technique applies simultaneous hybridization of numerous probes labeled with different reporter molecules which are distributed along the target chromosome allowing the detection of cytogenetic changes at near megabase-pair (Mbp) resolution. Here, we report our results using a probe set specific for human chromosome 10, which is altered in a significant portion of human thyroid cancers (TC's). While rendering accurate information about the cytogenetic location of rearranged elements, our multi-locus, multi-color analysis was developed primarily to overcome limitations of whole chromosome painting (WCP) and chromosome banding techniques for fine mapping of breakpoints in papillary thyroid cancer (PTC).

  1. SR9912

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    17, 1999 Media Contact: Bill Taylor (803) 725-2889 DOE Security Czar To Visit SRS August 18, 1999 Flag Ribbon Art General Eugene Habiger (USAF Ret.), the Department of Energy's Director of Security and Emergency Response will be at the Savannah River Site on Wednesday, August 18, 1999. Gen. Habiger, the former Commander-In-Chief, U.S. Strategic Command, has recently been named by the Secretary of Energy as the DOE's Security Czar. While at the Savannah River Site, he will visit first-hand

  2. R&D | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    R&D NNSA Administrator honors nonproliferation research leader Last week DOE Under Secretary for Nuclear Security and NNSA Administrator Lt. Gen. Frank G. Klotz (Ret.) presented the agency's Assistant Deputy Administrator for Nonproliferation Research and Development (R&D) Dr. Rhys Williams with the Distinguished Service Gold Medal Award at a... NNSA sites take home 15 R&D Awards R&D Magazine named 15 NNSA lab projects as winners in the 53rd annual R&D 100 Awards, which honor

  3. ASC-eNews-March-2008.indd

    National Nuclear Security Administration (NNSA)

    6 March 2008 Springtime in Washington Editorial by Bob Meisner Ret. General Smolen has introduced some organizational changes in Defense Programs at NNSA HQ. A major change that affects the ASC Program is that Dimitri Kusnezov has been asked to lead NA-11, I have assumed the role of acting ASC Division leader, and Njema Fra- zier is the acting deputy ASC Division Leader. Our budget continues to be a challenge. The Future-Years Nuclear Security Program (FYNSP) budget continues to drop until 2011

  4. IO2566

    Office of Legacy Management (LM)

    566 ;;I: :.f;l -5 iii i: i:2 JOSEPH OALIBER, EBQ., RKCEIVKR 513-519 WKBT 20th STREET NEW YORK, NKU YORK April 1, 1993 Former Sites Restoration Division Director U.S. Department of Energy, OR Operations P.O. BOX 2001 Oak Ridge, Tennessee 37831-8723 Ret 513-519 West 20th Street pew York. New York Dear Sir/Madam: Please be advised that pursuant to our remedial action license agreement dated November 30, premises (the t*License8q), 1992 relating to the above I hereby certify to you that the

  5. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 1, Introduction and summary

    SciTech Connect (OSTI)

    Rinne, R.L.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process -- and how -- would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies or exercise. The conference proceedings consist of three volumes. This volume, Volume 1, contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and discussion panels. Volume 2 contains a short introduction and the papers and presentations from the conference. Volume 3 contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.).

  6. The history of NATO TNF policy: The role of studies, analysis and exercises conference proceedings. Volume 2: Papers and presentations

    SciTech Connect (OSTI)

    Rinne, R.L.

    1994-02-01

    This conference was organized to study and analyze the role of simulation, analysis, modeling, and exercises in the history of NATO policy. The premise was not that the results of past studies will apply to future policy, but rather that understanding what influenced the decision process -- and how -- would be of value. The structure of the conference was built around discussion panels. The panels were augmented by a series of papers and presentations focusing on particular TNF events, issues, studies, or exercises. The conference proceedings consist of three volumes. Volume 1 contains the conference introduction, agenda, biographical sketches of principal participants, and analytical summary of the presentations and panels. This volume contains a short introduction and the papers and presentations from the conference. Volume 3 contains selected papers by Brig. Gen. Robert C. Richardson III (Ret.). Individual papers in this volume were abstracted and indexed for the database.

  7. LLNL Results from CALIBAN-PROSPERO Nuclear Accident Dosimetry Experiments in September 2014

    SciTech Connect (OSTI)

    Lobaugh, M. L.; Hickman, D. P.; Wong, C. W.; Wysong, A. R.; Merritt, M. J.; Heinrichs, D. P.; Topper, J. D.

    2015-05-21

    Lawrence Livermore National Laboratory (LLNL) uses thin neutron activation foils, sulfur, and threshold energy shielding to determine neutron component doses and the total dose from neutrons in the event of a nuclear criticality accident. The dosimeter also uses a DOELAP accredited Panasonic UD-810 (Panasonic Industrial Devices Sales Company of America, 2 Riverfront Plaza, Newark, NJ 07102, U.S.A.) thermoluminescent dosimetery system (TLD) for determining the gamma component of the total dose. LLNL has participated in three international intercomparisons of nuclear accident dosimeters. In October 2009, LLNL participated in an exercise at the French Commissariat à l’énergie atomique et aux énergies alternatives (Alternative Energies and Atomic Energy Commission- CEA) Research Center at Valduc utilizing the SILENE reactor (Hickman, et.al. 2010). In September 2010, LLNL participated in a second intercomparison at CEA Valduc, this time with exposures at the CALIBAN reactor (Hickman et al. 2011). This paper discusses LLNL’s results of a third intercomparison hosted by the French Institut de Radioprotection et de Sûreté Nucléaire (Institute for Radiation Protection and Nuclear Safety- IRSN) with exposures at two CEA Valduc reactors (CALIBAN and PROSPERO) in September 2014. Comparison results between the three participating facilities is presented elsewhere (Chevallier 2015; Duluc 2015).

  8. MELCOR 1.8.2 Analyses in Support of ITER’s RPrS

    SciTech Connect (OSTI)

    Brad J Merrill

    2008-01-01

    The International Thermonuclear Experimental Reactor (ITER) Program is performing accident analyses for ITER’s “Rapport Préliminaire de Sûreté” (Report Preliminary on Safety - RPrS) with a modified version of the MELCOR 1.8.2 code. The RPrS is an ITER safety document required in the ITER licensing process to obtain a “Décret Autorisation de Construction” (a Decree Authorizing Construction - DAC) for the ITER device. This report documents the accident analyses performed by the US with the MELCOR 1.8.2 code in support of the ITER RPrS effort. This work was funded through an ITER Task Agreement for MELCOR Quality Assurance and Safety Analyses. Under this agreement, the US was tasked with performing analyses for three accident scenarios in the ITER facility. Contained within the text of this report are discussions that identify the cause of these accidents, descriptions of how these accidents are likely to proceed, the method used to analyze the consequences of these accidents, and discussions of the transient thermal hydraulic and radiological release results for these accidents.

  9. The influence of TRP53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lemon, Jennifer A.; Taylor, Kristina; Verdecchia, Kyle; Phan, Nghi; Boreham, Douglas R.

    2014-01-01

    Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA double-strand breaks in bone marrow and genomic instability (MN-RET levels) in peripheral blood, between wild-type (Trp53+/+) and heterozygous (Trp53+/-) mice. The dose response for Trp53+/+ mice showed higher initial levelsmore » of radiation-induced lymphocyte apoptosis relative to Trp53+/- between 0 and 1 Gy. Although this trend was observed up to 12 hours post-irradiation, both genotypes ultimately reached the same level of apoptosis at 14 hours, suggesting the importance of late-onset p53-independent apoptotic responses in this mouse model. Expected radiation-induced G1 cell cycle delay was observed in Trp53+/+ but not Trp53+/-. Although p53 has an important role in cancer risk, we have shown its influence on radiation dose response can be temporally variable. This research highlights the importance of caution when using haematopoietic endpoints as surrogates to extrapolate radiation-induced cancer risk estimation.« less

  10. Cloud Properties and Radiative Heating Rates for TWP

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Comstock, Jennifer

    2013-11-07

    A cloud properties and radiative heating rates dataset is presented where cloud properties retrieved using lidar and radar observations are input into a radiative transfer model to compute radiative fluxes and heating rates at three ARM sites located in the Tropical Western Pacific (TWP) region. The cloud properties retrieval is a conditional retrieval that applies various retrieval techniques depending on the available data, that is if lidar, radar or both instruments detect cloud. This Combined Remote Sensor Retrieval Algorithm (CombRet) produces vertical profiles of liquid or ice water content (LWC or IWC), droplet effective radius (re), ice crystal generalized effective size (Dge), cloud phase, and cloud boundaries. The algorithm was compared with 3 other independent algorithms to help estimate the uncertainty in the cloud properties, fluxes, and heating rates (Comstock et al. 2013). The dataset is provided at 2 min temporal and 90 m vertical resolution. The current dataset is applied to time periods when the MMCR (Millimeter Cloud Radar) version of the ARSCL (Active Remotely-Sensed Cloud Locations) Value Added Product (VAP) is available. The MERGESONDE VAP is utilized where temperature and humidity profiles are required. Future additions to this dataset will utilize the new KAZR instrument and its associated VAPs.

  11. Cloud Properties and Radiative Heating Rates for TWP

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Comstock, Jennifer

    A cloud properties and radiative heating rates dataset is presented where cloud properties retrieved using lidar and radar observations are input into a radiative transfer model to compute radiative fluxes and heating rates at three ARM sites located in the Tropical Western Pacific (TWP) region. The cloud properties retrieval is a conditional retrieval that applies various retrieval techniques depending on the available data, that is if lidar, radar or both instruments detect cloud. This Combined Remote Sensor Retrieval Algorithm (CombRet) produces vertical profiles of liquid or ice water content (LWC or IWC), droplet effective radius (re), ice crystal generalized effective size (Dge), cloud phase, and cloud boundaries. The algorithm was compared with 3 other independent algorithms to help estimate the uncertainty in the cloud properties, fluxes, and heating rates (Comstock et al. 2013). The dataset is provided at 2 min temporal and 90 m vertical resolution. The current dataset is applied to time periods when the MMCR (Millimeter Cloud Radar) version of the ARSCL (Active Remotely-Sensed Cloud Locations) Value Added Product (VAP) is available. The MERGESONDE VAP is utilized where temperature and humidity profiles are required. Future additions to this dataset will utilize the new KAZR instrument and its associated VAPs.

  12. The influence of TRP53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

    SciTech Connect (OSTI)

    Lemon, Jennifer A.; Taylor, Kristina; Verdecchia, Kyle; Phan, Nghi; Boreham, Douglas R.

    2014-01-01

    Apoptotic and DNA damage endpoints are frequently used as surrogate markers of cancer risk, and have been well-studied in the Trp53+/- mouse model. We report the effect of differing Trp53 gene status on the dose response of ionizing radiation exposures (0.01-2 Gy), with the unique perspective of determining if effects of gene status remain at extended time points. Here we report no difference in the dose response for radiation-induced DNA double-strand breaks in bone marrow and genomic instability (MN-RET levels) in peripheral blood, between wild-type (Trp53+/+) and heterozygous (Trp53+/-) mice. The dose response for Trp53+/+ mice showed higher initial levels of radiation-induced lymphocyte apoptosis relative to Trp53+/- between 0 and 1 Gy. Although this trend was observed up to 12 hours post-irradiation, both genotypes ultimately reached the same level of apoptosis at 14 hours, suggesting the importance of late-onset p53-independent apoptotic responses in this mouse model. Expected radiation-induced G1 cell cycle delay was observed in Trp53+/+ but not Trp53+/-. Although p53 has an important role in cancer risk, we have shown its influence on radiation dose response can be temporally variable. This research highlights the importance of caution when using haematopoietic endpoints as surrogates to extrapolate radiation-induced cancer risk estimation.

  13. A Comparison of Modifications to MELCOR versions 1.8.2 and 1.8.6 for ITER Safety Analysis

    SciTech Connect (OSTI)

    B. J. Merrill; P. W. Humrickhouse

    2010-06-01

    During the Engineering Design Activity of the International Thermonuclear Experimental Reactor (ITER), the MELCOR 1.8.2 code was selected as one of several codes to be used to perform ITER safety analyses [1]. MELCOR was chosen because it has the capability of predicting coolant pressure, temperature, mass flow rate, and radionuclide and aerosol transport in nuclear facilities and reactor cooling systems. MELCOR can also predict structural temperatures (e.g. first wall, blanket, divertor, and vacuum vessel) resulting from energy produced by radioactive decay heat and/or chemical reactions (oxidation). The Idaho National Laboratory (INL) Fusion Safety Program (FSP) made fusion specific modifications to the MELCOR 1.8.2 code [2-6], including models for water freezing, air condensation, beryllium, carbon, and tungsten oxidation in steam and air environments, flow boiling in coolant loops, and radiation in enclosures, that allowed MELCOR to assess the thermal hydraulic response of ITER cooling systems and the transport of radionuclides as aerosols during accident conditions. Recently, the ITER International Organization (IO) used a “pedigreed” version of MELCOR 1.8.2 [7] to perform accident analyses for ITER’s “Rapport Préliminaire de Sûreté” (Report Preliminary on Safety - RPrS). The MELCOR thermal-hydraulics code [8] is currently under development at the Sandia National Laboratory (SNL) for the US Nuclear Regulatory Commission (NRC). MELCOR is used to model the progression of severe accidents in light water fission reactors. Because MELCOR has undergone many improvements between version 1.8.2 and 1.8.6, the INL FSP decided to introduce fusion modifications into MELCOR 1.8.6, and thereby produce a version of MELCOR 1.8.6 with similar capabilities to the pedigreed version of MELCOR 1.8.2 used for the ITER RPrS. We have applied this version of MELCOR 1.8.6 to the same set of problems used in the MELCOR 1.8.2 pedigree analysis [7]. Section 2 describes a non-regression analysis that involves comparing the results from the modified version of MELCOR 1.8.6 against those predicted by the original, unmodified version of MELCOR 1.8.6. The purpose of this non-regression analysis is to demonstrate that the modifications made to the MELCOR 1.8.6 code do not drastically alter the intended functions of the MELCOR base code, and if they do to explain why the departure occurs and if the change is needed. The analysis was performed using the demonstration problem that came with the MELCOR 1.8.6 source distribution. Section 3 makes a comparison between the pedigreed version of MELCOR 1.8.2 and the new modified version of MELCOR 1.8.6 on a set of accident problems used by the ITER Joint Central Team (JCT) in the Generic Site Safety Report (GSSR) [9]. Finally, in section 4, the two versions of the code are compared on a series of developmental test problems described in the change documents [2-4, 6].