National Library of Energy BETA

Sample records for respiratory disease orthopedic

  1. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  2. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  3. Climate Change and Our Environment: The Effect on Respiratory and Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    Climate Change and Our Environment: The Effect on Respiratory and Allergic Disease Charles S; Atlanta, Ga; Tulsa, Okla; Los Angeles, Calif; and Boston, Mass Climate change is a constant and ongoing climate change. It provides suggestions to help the allergist/environmental physician integrate recommenda

  4. Respiratory disease and particulate air pollution in Santiago Chile: Contribution of erosion particles from fine sediments

    E-Print Network [OSTI]

    Commentary Respiratory disease and particulate air pollution in Santiago Chile: Contribution pollution Santiago Erosion Sedimentation a b s t r a c t Air pollution in Santiago is a serious problem for a couple of days, followed by extreme levels of air pollution. Current regulations focus mostly on PM10

  5. Nanostructured apatites as orthopedic biomaterials

    E-Print Network [OSTI]

    Ahn, Edward Sun, 1972-

    2001-01-01

    Historically, using suitable mechanical replacements for bone has been a priority in designing permanent, load-bearing orthopedic implants. As a result, the biomaterials used in these implants have been largely limited to ...

  6. Prevalence of respiratory symptoms and diseases in schoolchildren living in a polluted and in a low polluted area in Israel

    SciTech Connect (OSTI)

    Goren, A.I.; Hellmann, S.

    1988-02-01

    Second and fifth grade schoolchildren living in two communities with different levels of air pollution were studied. The parents of these children filled out ATS-NHLI health questionnaires. The prevalence of reported respiratory symptoms and pulmonary diseases was found to be significantly higher among children growing up in the polluted community (Ashdod) as compared with the low-pollution area (Hadera). Logistic models fitted for the respiratory conditions which differed significantly between both areas of residence also included background variables that could be responsible for these differences. Relative risk values, which were calculated from the logistic models, were in the range of 1.47 for cough without cold to 2.66 for asthma for children from Ashdod, as compared with 1.00 for children from Hadera.

  7. Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report

    E-Print Network [OSTI]

    McCormick, Liam M; Goddard, Martin; Mahadeva, Ravi

    2008-08-05

    . It is partic- ularly important to obtain an accurate diagnosis of inter- stitial shadowing on chest radiograph as pulmonary siderosis in our patient had a relatively good prognosis compared with other interstitial and small airway disor- ders. Abbreviations FEV... ]. All subjects, however, remained in good health, leading to the conclusion that siderosis (in its pure form) was not associated with respiratory symptoms or functional impairment. This view was supported by sub- sequent pathological investigations...

  8. Correlation of Klebsiella pneumoniae Comparative Genetic Analyses with Virulence Profiles in a Murine Respiratory Disease Model

    E-Print Network [OSTI]

    Fodah, Ramy A.

    Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied ...

  9. Effects of Air Pollution on Respiratory Disease Asthma, closely associated with air pollution, affects nearly 15 million people in the United States, one-third of them

    E-Print Network [OSTI]

    Schladow, S. Geoffrey

    Effects of Air Pollution on Respiratory Disease Asthma, closely associated with air pollution as a greater understanding of the types of air pollutants that cause the most harm. Seminal findings, supporting a proposed update to existing air quality standards. Air pollutant ozone causes childhood asthma

  10. Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein 

    E-Print Network [OSTI]

    Herlihy, Sarah E

    2014-06-05

    The work in this dissertation links two diseases through a protein secreted by Dictyostelium discoideum cells. The protein, AprA, inhibits cell proliferation and induces chemorepulsion (movement away) of Dictyostelium cells. This has implications...

  11. Development of a novel orthopedic microfastener 

    E-Print Network [OSTI]

    Agnihotri, Mukul Mukund

    2007-04-25

    Over the last decade, biodegradable screws and plates have received wide acceptance over metallic fasteners for orthopedic fracture fixation. A biodegradable fastener would gradually "disappear" during healing of a fractured bone or tissues...

  12. Porcine Reproductive and Respiratory Syndrome 

    E-Print Network [OSTI]

    Lawhorn, D. Bruce

    2001-07-25

    Porcine reproductive and respiratory syndrome (PRRS) is becoming one of the most economically significant diseases of swine. It causes weak, stillborn and mummified pigs, and sometimes losses of entire litters. This publication describes the disease...

  13. CFD modeling and image analysis of exhaled aerosols due to a growing bronchial tumor: Towards non-invasive diagnosis and treatment of respiratory obstructive diseases

    SciTech Connect (OSTI)

    Xi, Jinxiang [Central Michigan Univ., Mount Pleasant, MI (United States); Kim, JongWon [Central Michigan Univ., Mount Pleasant, MI (United States); Si, Xiuhua A. [California Baptist Univ., Riverside, CA (United States); Corley, Richard A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kabilan, Senthil [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wang, Shengyu [First Affiliated Hospital of Xi'an Medical Univ., Shaanxi (China); Mayo Clinic, Rochester, MN (United States)

    2015-01-01

    Diagnosis and prognosis of tumorigenesis are generally performed with CT, PET, or biopsy. Such methods are accurate, but have the limitations of high cost and posing additional health risks to patients. In this study, we introduce an alternative computer aided diagnostic tool that can locate malignant sites caused by tumorigenesis in a non-invasive and low-cost way. Our hypothesis is that exhaled aerosol distribution is unique to lung structure and is sensitive to airway structure variations. With appropriate approaches, it is possible to locate the disease site, determine the disease severity, and subsequently formulate a targeted drug delivery plan to treat the disease. This study numerically evaluated the feasibility of the proposed breath test in an image-based lung model with varying pathological stages of a bronchial squamous tumor. Large eddy simulations and a Lagrangian tracking approach were used to model respiratory airflows and aerosol dynamics. Respirations of tracer aerosols of 1 ?m at a flow rate of 20 L/min were simulated, with the distributions of exhaled aerosols recorded on a filter at the mouth exit. Aerosol patterns were quantified with multiple analytical techniques such as concentration disparity, spatial scanning and fractal analysis. We demonstrated that a growing bronchial tumor induced notable variations in both the airflow and exhaled aerosol distribution. These variations became more apparent with increasing tumor severity. The exhaled aerosols exhibited distinctive pattern parameters such as spatial probability, fractal dimension, and multifractal spectrum. Results of this study show that morphometric measures of the exhaled aerosol pattern can be used to detect and monitor the pathological states of respiratory diseases in the upper airway. The proposed breath test also has the potential to locate the site of the disease, which is critical in developing a personalized, site-specific drug delivery protocol.

  14. CFD modeling and image analysis of exhaled aerosols due to a growing bronchial tumor: Towards non-invasive diagnosis and treatment of respiratory obstructive diseases

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xi, Jinxiang; Kim, JongWon; Si, Xiuhua A.; Corley, Richard A.; Kabilan, Senthil; Wang, Shengyu

    2015-01-01

    Diagnosis and prognosis of tumorigenesis are generally performed with CT, PET, or biopsy. Such methods are accurate, but have the limitations of high cost and posing additional health risks to patients. In this study, we introduce an alternative computer aided diagnostic tool that can locate malignant sites caused by tumorigenesis in a non-invasive and low-cost way. Our hypothesis is that exhaled aerosol distribution is unique to lung structure and is sensitive to airway structure variations. With appropriate approaches, it is possible to locate the disease site, determine the disease severity, and subsequently formulate a targeted drug delivery plan to treatmore »the disease. This study numerically evaluated the feasibility of the proposed breath test in an image-based lung model with varying pathological stages of a bronchial squamous tumor. Large eddy simulations and a Lagrangian tracking approach were used to model respiratory airflows and aerosol dynamics. Respirations of tracer aerosols of 1 ?m at a flow rate of 20 L/min were simulated, with the distributions of exhaled aerosols recorded on a filter at the mouth exit. Aerosol patterns were quantified with multiple analytical techniques such as concentration disparity, spatial scanning and fractal analysis. We demonstrated that a growing bronchial tumor induced notable variations in both the airflow and exhaled aerosol distribution. These variations became more apparent with increasing tumor severity. The exhaled aerosols exhibited distinctive pattern parameters such as spatial probability, fractal dimension, and multifractal spectrum. Results of this study show that morphometric measures of the exhaled aerosol pattern can be used to detect and monitor the pathological states of respiratory diseases in the upper airway. The proposed breath test also has the potential to locate the site of the disease, which is critical in developing a personalized, site-specific drug delivery protocol.« less

  15. A Novel Wireless Health Orthopedic System Integrating Motion and Acoustic Emission Monitoring

    E-Print Network [OSTI]

    Paul, Manda

    2013-01-01

    id/ds-260/lang/en›. [10] Wireless Ethernet Bridge (WET54G).Los Angeles A Novel Wireless Health Orthopedic SystemOF THE THESIS A Novel Wireless Health Orthopedic System

  16. Elec 331 -Respiratory System Respiratory & CV Systems

    E-Print Network [OSTI]

    Pulfrey, David L.

    ) during heavy breathing Transport (Respiratory) Natural state of lung #12;Elec 331 - Respiratory System 2 - Respiratory System 4 Measurements · Composition ­ End-tidal CO2 · Volume / Capacity (CC) ­ Spirometry SRC: www.anaesthesiauk.com gas velocity ultrasonic wave velocity gV c xmit recv gV c gV cosg

  17. Bovine Respiratory Disease Max Irsik DVM, MAB

    E-Print Network [OSTI]

    Watson, Craig A.

    . The clinical signs are usually mild and involve coughing, nasal discharge, fever and a decreased appetite signs of BRD are nasal and eye discharges, coughing, fever, depressed appetite, varying degrees

  18. Multiplex detection of respiratory pathogens

    DOE Patents [OSTI]

    McBride, Mary (Brentwood, CA); Slezak, Thomas (Livermore, CA); Birch, James M. (Albany, CA)

    2012-07-31

    Described are kits and methods useful for detection of respiratory pathogens (influenza A (including subtyping capability for H1, H3, H5 and H7 subtypes) influenza B, parainfluenza (type 2), respiratory syncytial virus, and adenovirus) in a sample. Genomic sequence information from the respiratory pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay to successfully identify the presence or absence of pathogens in a sample.

  19. In-vivo orthopedic implant diagnostic device for sensing load, wear, and infection

    DOE Patents [OSTI]

    Evans, III, Boyd McCutchen; Thundat, Thomas G.; Komistek, Richard D.; Dennis, Douglas A.; Mahfouz, Mohamed

    2006-08-29

    A device for providing in vivo diagnostics of loads, wear, and infection in orthopedic implants having at least one load sensor associated with the implant, at least one temperature sensor associated with the implant, at least one vibration sensor associated with the implant, and at least one signal processing device operatively coupled with the sensors. The signal processing device is operable to receive the output signal from the sensors and transmit a signal corresponding with the output signal.

  20. Respiratory Protective 231 Corstorphine Road

    E-Print Network [OSTI]

    1 Respiratory Protective Equipment 231 Corstorphine Road Edinburgh EH12 7AT www.forestry.gov.uk J U to sustain life. · The equipment used must be suitable for the intended purpose. This means it must provide

  1. Respiratory correlated cone beam CT

    SciTech Connect (OSTI)

    Sonke, Jan-Jakob; Zijp, Lambert; Remeijer, Peter; Herk, Marcel van [Department of Radiation Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam (Netherlands)

    2005-04-01

    A cone beam computed tomography (CBCT) scanner integrated with a linear accelerator is a powerful tool for image guided radiotherapy. Respiratory motion, however, induces artifacts in CBCT, while the respiratory correlated procedures, developed to reduce motion artifacts in axial and helical CT are not suitable for such CBCT scanners. We have developed an alternative respiratory correlated procedure for CBCT and evaluated its performance. This respiratory correlated CBCT procedure consists of retrospective sorting in projection space, yielding subsets of projections that each corresponds to a certain breathing phase. Subsequently, these subsets are reconstructed into a four-dimensional (4D) CBCT dataset. The breathing signal, required for respiratory correlation, was directly extracted from the 2D projection data, removing the need for an additional respiratory monitor system. Due to the reduced number of projections per phase, the contrast-to-noise ratio in a 4D scan reduced by a factor 2.6-3.7 compared to a 3D scan based on all projections. Projection data of a spherical phantom moving with a 3 and 5 s period with and without simulated breathing irregularities were acquired and reconstructed into 3D and 4D CBCT datasets. The positional deviations of the phantoms center of gravity between 4D CBCT and fluoroscopy were small: 0.13{+-}0.09 mm for the regular motion and 0.39{+-}0.24 mm for the irregular motion. Motion artifacts, clearly present in the 3D CBCT datasets, were substantially reduced in the 4D datasets, even in the presence of breathing irregularities, such that the shape of the moving structures could be identified more accurately. Moreover, the 4D CBCT dataset provided information on the 3D trajectory of the moving structures, absent in the 3D data. Considerable breathing irregularities, however, substantially reduces the image quality. Data presented for three different lung cancer patients were in line with the results obtained from the phantom study. In conclusion, we have successfully implemented a respiratory correlated CBCT procedure yielding a 4D dataset. With respiratory correlated CBCT on a linear accelerator, the mean position, trajectory, and shape of a moving tumor can be verified just prior to treatment. Such verification reduces respiration induced geometrical uncertainties, enabling safe delivery of 4D radiotherapy such as gated radiotherapy with small margins.

  2. Investigation of a HA/PDLGA/Carbon Foam Material System for Orthopedic Fixation Plates Based on Time-Dependent Properties 

    E-Print Network [OSTI]

    Rodriguez, Douglas E.

    2010-01-14

    Page 1.1 Mechanical properties of bone and typical metallic and ceramic biomaterials [12] (as detailed by Ramakrishna et al. [13]) ............................. 4 1.1 Mechanical properties of typical bioresorbable polymers [14... The use of bioresorbable polymers, materials that degrade within the body and are resorbed through the body’s metabolic cycle, has been proposed for orthopedic applications since the advent of these polymers as a biomaterial[1]. Since the introduction...

  3. Navajo Coal Combustion and Respiratory Health Near Shiprock, New Mexico

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bunnell, Joseph E.; Garcia, Linda V.; Furst, Jill M.; Lerch, Harry; Olea, Ricardo A.; Suitt, Stephen E.; Kolker, Allan

    2010-01-01

    Indoor air pollution has been identified as a major risk factor for acute and chronic respiratory diseases throughout the world. In the sovereign Navajo Nation, an American Indian reservation located in the Four Corners area of the USA, people burn coal in their homes for heat. To explore whether/how indoor coal combustion might contribute to poor respiratory health of residents, this study examined respiratory health data, identified household risk factors such as fuel and stove type and use, analyzed samples of locally used coal, and measured and characterized fine particulate airborne matter inside selected homes. In twenty-five percent ofmore »homes surveyed coal was burned in stoves not designed for that fuel, and indoor air quality was frequently found to be of a level to raise concerns. The average winter 24-hour PM 2.5 concentration in 20 homes was 36.0? ? g/ m 3 . This is the first time that PM 2.5 has been quantified and characterized inside Navajo reservation residents' homes. « less

  4. Effects of air pollution on the respiratory health of children: a cross-sectional study

    SciTech Connect (OSTI)

    Spinaci, S.; Arossa, W.; Bugiani, M.; Natale, P.; Bucca, C.; de Candussio, G.

    1985-09-01

    To investigate the effects of air pollution on the respiratory health of children, a subject of some controversy, a comparative study was undertaken of 2,385 school children who lived in central urban, peripheral urban, and suburban areas. Daily monitoring of sulfur dioxide and total suspended particle concentrations in all areas showed that pollutant concentrations in central and peripheral urban areas were above commonly accepted safety levels for respiratory health, while concentrations in the suburban area were within acceptable limits. A questionnaire administered to each mother assessed environmental exposure to pollutants in the household, the occurrence of respiratory symptoms as well as lung diseases as diagnosed by a physician, and general information. Children were interviewed about smoking habits and any acute respiratory symptoms. Children also performed standard lung function tests. Results showed that children from both urban areas had lessened pulmonary function and a higher prevalence of bronchial secretion with common colds than did those from the suburban area. These differences persisted after corrections for exposure to indoor pollutants, active or passive smoking, socioeconomic status, and sex. Parental cigarette smoking was related to a fall in forced expiratory volume in 1 second and an increased incidence of acute respiratory illnesses and chronic cough in children. Although boys had higher lung volumes and lower air flow, regression analysis showed no significant influence of the interactions sex-geographic area and sex-smoking on lung function. It was concluded that air pollution has a significant effect on the respiratory health of children.

  5. Chair, Department of Respiratory Therapy BYRDINE F. LEWIS SCHOOL OF NURSING AND HEALTH PROFESSIONS

    E-Print Network [OSTI]

    Frantz, Kyle J.

    Chair, Department of Respiratory Therapy BYRDINE F. LEWIS SCHOOL OF NURSING AND HEALTH PROFESSIONS The Byrdine F. Lewis School of Nursing and Health Professions invites applications and nominations for Disease Control and Prevention and the American Cancer Society. As part of the new campus master plan

  6. LANL spinoff receives NIH grant for respiratory disease diagnostic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2006 to fill a funding gap that slowed the commercialization of technologies by Northern New Mexico companies. Mesa Tech also participated successfully in LANL's New Mexico Small...

  7. Bovine Respiratory Disease Pathogens in Pre-weaned Holstein Calves

    E-Print Network [OSTI]

    Collins, Gary S.

    , presence of nasal discharge and cough, and eye or ear appearance. Scores ranged from 0 to 12 with calves such as fever, rapid breathing, repetitive coughing, nasal and/or eye discharge, diarrhea, dehydration

  8. LANL spinoff receives NIH grant for respiratory disease diagnostic device

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse Bergkamp Graduate student Subtask2 J.N.open to badgeLANL selectsLANL

  9. Modeling the Dynamics of Fermentation and Respiratory

    E-Print Network [OSTI]

    Sheffield, University of

    Modeling the Dynamics of Fermentation and Respiratory Processes in a Groundwater Plume of Phenolic implemented into a field- scale reactive transport model of a groundwater plume of phenolic contaminants toxicity toward degradation, bioavailability of mineral oxides, and adsorption of biogenic Fe(II) species

  10. REGULAR ARTICLE A Simple Dynamic Model of Respiratory Pump

    E-Print Network [OSTI]

    Fontecave-Jallon, Julie

    REGULAR ARTICLE A Simple Dynamic Model of Respiratory Pump Pascale Calabrese · Pierre Baconnier the relative motion of rib cage and abdomen during quiet breathing. Keywords Respiratory pump model Á. Hillman and Finucane (1987) have produced a simple model of the respiratory pump that ``appears

  11. Nitrogen dioxide and respiratory illnesses in infants

    SciTech Connect (OSTI)

    Samet, J.M.; Lambert, W.E.; Skipper, B.J.; Cushing, A.H.; Hunt, W.C.; Young, S.A.; McLaren, L.C.; Schwab, M.; Spengler, J.D. )

    1993-11-01

    Nitrogen dioxide is an oxidant gas that contaminates outdoor air and indoor air in homes with unvented gas appliances. A prospective cohort study was carried out to test the hypothesis that residential exposure to NO2 increases incidence and severity of respiratory illnesses during the first 18 months of life. A cohort of 1,205 healthy infants from homes without smokers was enrolled. The daily occurrence of respiratory symptoms and illnesses was reported by the mothers every 2 wk. Illnesses with wheezing or wet cough were classified as lower respiratory tract. Indoor NO2 concentrations were serially measured with passive samplers place in the subjects' bedrooms. In stratified analyses, illness incidence rates did not consistently increase with exposure to NO2 or stove type. In multivariate analyses that adjusted for potential confounding factors, odds ratios were not significantly elevated for current or lagged NO2 exposures, or stove type. Illness duration, a measure of illness severity, was not associated with NO2 exposure. The findings can be extended to homes with gas stoves in regions of the United States where the outdoor air is not heavily polluted by NO2.

  12. Participatory epidemiology : harnessing the HealthMap platform for community-based disease outbreak monitoring

    E-Print Network [OSTI]

    Freifeld, Clark

    2010-01-01

    Due to increasing global trade and travel along with a range of environmental factors, emerging infectious diseases such as Severe Acute Respiratory Syndrome (SARS), drug-resistant tuberculosis, and 2009 HiNi continue to ...

  13. The Relationship Between the Prevalence of Respiratory Illness and Dermatitis and Infant Diet in the First Year of Life

    E-Print Network [OSTI]

    Kunz, Lara

    2009-04-09

    for asthma and allergic disease since the 12th century when a Jewish physician and philosopher, Maimonides, produced a remedy of Rhazes to ?clear the lungs of moisture, ease respiration and eliminate the cough? (32). The relationship of the environment...-wheezing lower respiratory infections included chest infection, pneumonia, whooping cough, chronic cough, or croup. As a check for reliability and validity of parental reporting of illnesses, the investigators compared 100 hospital medical records against...

  14. NICS report links VOCs to respiratory problems

    SciTech Connect (OSTI)

    Kirschner, E.

    1992-04-22

    Children who live near the chemical plants of Kanawha Valley, WV, suffer more acute and chronic respiratory aliments than those farther away, says a Harvard University School of Public Health report. In the $1-million, five-year study commissioned by the National Institute for Chemical Studies (NICS:Charleston, WV) and funded by the Environmental Protection Agency, proximity to chemical plants that emit volatile organic compounds (VOCs) was linked to higher incidence of asthma, acute eye irritation, shortness of breath, and chronic cough. The researchers say they adjusted for most other factors, such as parental smoking and petroleum. {open_quotes}The research hypothesis was whether children in the valley had more symptoms,{close_quotes} says NICS president Paul Hill. {open_quotes}Yes, there is a difference.{close_quotes} The study showed that some ailments were up to 28% more prevalent in children in the valley than in other Kanawha County children.

  15. Chronic respiratory effects of indoor formaldehyde exposure

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Quackenboss, J.J.; Lebowitz, M.D.

    1990-01-01

    The relation of chronic respiratory symptoms and pulmonary function to formaldehyde (HCHO) in homes was studied in a sample of 298 children (6-15 years of age) and 613 adults. HCHO measurements were made with passive samplers two one-week periods. Data on chronic cough and phlegm, wheeze, attacks of breathlessness, and doctor diagnoses of chronic bronchitis and asthma were collected with self-completed questionnaires. Peak expiratory flow rates (PEFR) were obtained during the evenings and mornings for up to 14 consecutive days for each individual. Significantly greater prevalence rates of asthma and chronic bronchitis were found in children from houses with HCHO levels 60-120 ppb than in those less exposed, especially in children also exposed to environmental tobacco smoke. In children, levels of PEFR linearly decreased with HCHO exposure, with estimated decrease due to 60 ppb of HCHO equivalent to 22% of PEFR level in nonexposed children.

  16. Occupational exposures and chronic respiratory symptoms. A population-based study

    SciTech Connect (OSTI)

    Korn, R.J.; Dockery, D.W.; Speizer, F.E.; Ware, J.H.; Ferris, B.G. Jr.

    1987-08-01

    Data from a random sample of 8515 white adults residing in 6 cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms; 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalences of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared with unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR = 1.53, 95% Cl = 1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory symptoms and disease can be independently associated with occupational exposures.

  17. Occupational exposures and chronic respiratory symptoms: a population-based study

    SciTech Connect (OSTI)

    Korn, R.J.; Dockery, D.W.; Speizer, F.E.; Ware, J.H.; Ferris, B.G.

    1987-01-01

    Data from a random sample of 8515 white adults residing in six cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms. 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or to fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalence of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared to unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease (COPD) as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR=1.53, 95% CI=1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory disease can be independently associated with occupational exposures.

  18. Chronic respiratory effects of indoor formaldehyde exposure

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Quackenboss, J.J.; Lebowitz, M.D. )

    1990-08-01

    The relation of chronic respiratory symptoms and pulmonary function to formaldehyde (HCHO) in homes was studied in a sample of 298 children (6-15 years of age) and 613 adults. HCHO measurements were made with passive samplers during two 1-week periods. Data on chronic cough and phlegm, wheeze, attacks of breathlessness, and doctor diagnoses of chronic bronchitis and asthma were collected with self-completed questionnaires. Peak expiratory flow rates (PEFR) were obtained during the evenings and mornings for up to 14 consecutive days for each individual. Significantly greater prevalence rates of asthma and chronic bronchitis were found in children from houses with HCHO levels 60-120 ppb than in those less exposed, especially in children also exposed to environmental tobacco smoke. In children, levels of PEFR decreased linearly with HCHO exposure, with the estimated decrease due to 60 ppb of HCHO equivalent to 22% of PEFR level in nonexposed children. The effects in asthmatic children exposed to HCHO below 50 ppb were greater than in healthy ones. The effects in adults were less evident: decrements in PEFR due to HCHO over 40 ppb were seen only in the morning, and mainly in smokers.

  19. Measuring the mechanical properties of the respiratory system in patients

    E-Print Network [OSTI]

    Hayden, Nancy J.

    Measuring the mechanical properties of the respiratory system in patients on mechanical ventilators is currently widely performed by measuring pressure and flow delivered by a mechanical ventilator. However, when a patient is partially breathing for themselves, accurate mechanical parameters cannot

  20. Biomechanics of the Lung 1 HUMAN RESPIRATORY MECHANICS, part 1

    E-Print Network [OSTI]

    Prestwich, Ken

    Biomechanics of the Lung 1 HUMAN RESPIRATORY MECHANICS, part 1: THE BIOMECHANICS OF THE LUNG1 Summary: We begin a detailed study of ventilation and then examine the static forces that exist in lungs at different volumes

  1. Regional respiratory tract absorption of inhaled reactive gases

    SciTech Connect (OSTI)

    Miller, F.J.; Overton, J.H.; Kimbell, J.S.; Russell, M.L.

    1992-06-29

    Highly reactive gases present unique problems due to the number of factors which must be taken into account to determine regional respiratory tract uptake. The authors reviewed some of the physical, chemical, and biological factors that affect dose and that must be understood to interpret toxicological data, to evaluate experimental dosimetry studies, and to develop dosimetry models. Selected dosimetry experiments involving laboratory animals and humans were discussed, showing the variability and uptake according to animal species and respiratory tract region for various reactive gases. New experimental dosimetry approaches, such as those involving isotope ratio mass spectroscopy and cyclotron generation reactive gases, were discussed that offer great promise for improving the ability to study regional respiratory tract absorption of reactive gases. Various dosimetry modeling applications were discussed which demonstrate: the importance of airflow patterns for site-specific dosimetry in the upper respiratory tract, the influence of the anatomical model used to make inter- and intraspecies dosimetric comparisons, the influence of tracheobronchial path length on predicted dose curves, and the implications of ventilatory unit structure and volume on dosimetry and response. Collectively, these examples illustrate important aspects of regional respiratory tract absorption of inhaled reactive gases. Given the complex nature of extent and pattern of injury in the respiratory tract from exposure to reactive gases, understanding interspecies differences in the absorption of reactive gases will continue to be an important area for study.

  2. The effects of maintenance schedules following pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomised controlled trial

    E-Print Network [OSTI]

    Wilson, Andrew M.; Browne, Paula; Olive, Sandra; Clark, Allan; Galey, Penny; Dix, Emma; Woodhouse, Helene; Robinson, Sue; Wilson, Edward C. F.; Staunton, Lindi

    2015-03-11

    %. Patients were excluded if they had significant cardiac or pulmonary disease other than COPD, a myocardial infarction within the previous 6 months or unstable angina, respiratory infection (defined as cough, anti- biotic use or purulent sputum within 4 weeks...

  3. Human torso phantom for imaging of heart with realistic modes of cardiac and respiratory motion

    DOE Patents [OSTI]

    Boutchko, Rostyslav; Balakrishnan, Karthikayan; Gullberg, Grant T; O'Neil, James P

    2013-09-17

    A human torso phantom and its construction, wherein the phantom mimics respiratory and cardiac cycles in a human allowing acquisition of medical imaging data under conditions simulating patient cardiac and respiratory motion.

  4. What is the flu? Influenza, "the flu" is a contagious respiratory infection

    E-Print Network [OSTI]

    Virginia Tech

    What is the flu? Influenza, "the flu" is a contagious respiratory infection caused by the influenza medications are used. How is flu spread? The influenza virus is very contagious and is spread by respiratory

  5. Neural adaptive mechanisms in respiratory regulation : theory and experiments

    E-Print Network [OSTI]

    Young, Daniel Laurence

    2002-01-01

    The respiratory regulatory system is an example of a complex biological control system. The principle goal of the regulator is to preserve the chemical balance of 02, CO2 and pH in the body. Although much is known about ...

  6. Sorghum Diseases

    E-Print Network [OSTI]

    Amador, Jose; Berry, Robert W.; Frederiksen, Richard A.; Horne, C. Wendell; Thames, Walter H.; Toler, Robert W.

    1969-01-01

    Foreign animal disease can cause serious damage to the United States (US) agricultural sector and foot-and-mouth disease (FMD), in particular, poses a serious threat. FMD causes death and reduced fecundity in infected ...

  7. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  8. Effects of inhalable particles on respiratory health of children

    SciTech Connect (OSTI)

    Dockery, D.W.; Speizer, F.E.; Stram, D.O.; Ware, J.H.; Spengler, J.D.; Ferris, B.G. Jr.

    1989-03-01

    Results are presented from a second cross-sectional assessment of the association of air pollution with chronic respiratory health of children participating in the Six Cities Study of Air Pollution and Health. Air pollution measurements collected at quality-controlled monitoring stations included total suspended particulates (TSP), particulate matter less than 15 microns (PM15) and 2.5 microns (PM2.5) aerodynamic diameter, fine fraction aerosol sulfate (FSO4), SO2, O3, and No2. Reported rates of chronic cough, bronchitis, and chest illness during the 1980-1981 school year were positively associated with all measures of particulate pollution (TSP, PM15, PM2.5, and FSO4) and positively but less strongly associated with concentrations of two of the gases (SO2 and NO2). Frequency of earache also tended to be associated with particulate concentrations, but no associations were found with asthma, persistent wheeze, hay fever, or nonrespiratory illness. No associations were found between pollutant concentrations and any of the pulmonary function measures considered (FVC, FEV1, FEV0.75, and MMEF). Children with a history of wheeze or asthma had a much higher prevalence of respiratory symptoms, and there was some evidence that the association between air pollutant concentrations and symptom rates was stronger among children with these markers for hyperreactive airways. These data provide further evidence that rates of respiratory illnesses and symptoms are elevated among children living in cities with high particulate pollution. They also suggest that children with hyperreactive airways may be particularly susceptible to other respiratory symptoms when exposed to these pollutants.

  9. About the Air Pollution and Respiratory Health Program The Air Pollution and Respiratory Health Program of the National Center for Environmental Health, Centers for

    E-Print Network [OSTI]

    About the Air Pollution and Respiratory Health Program The Air Pollution and Respiratory Health indoor and outdoor air pollution. CDC's asthma program focuses on three main activities: (1) tracking public health agencies. For example, CDC staff are currently studying the effect of outdoor air pollution

  10. Identification and characterization of a virus isolated from bobwhite quail with a respiratory disease 

    E-Print Network [OSTI]

    DuBose, Robert Trafton

    1958-01-01

    $ Desori t 0 of the Diss ~ The outbreak of quail bronchitis reported by Olson ooeurre4 21 in 1949 at the Best Virgixd. a State Game Farm. Coughing and unseeing was observed in some of the adult bobshite quail, In young bixds spnptons first eccurred... at $ weeks of age. Foe4 con suaptien droype4 and coughing, encasing an4 tales were noto4. Basal disoharge was not seen. Bending cf the neck between tho wings or legs occurred in 2 to ) yoreent of the birds. The course of the dieoase was 1 to $ weeks...

  11. Evaluation of Two Methods to Prevent Bovine Respiratory Disease in Growing Cattle 

    E-Print Network [OSTI]

    Word, Alyssa Brook

    2014-07-09

    performance outcomes were not different, animal health was improved with metaphylaxis. A second trial was conducted to determine the effects of limit-feeding growing steers on immune function. Thirty-two steers were fed the same ration at one of three intake...

  12. SU-E-I-63: Quantitative Evaluation of the Effects of Orthopedic Metal Artifact Reduction (OMAR) Software On CT Images for Radiotherapy Simulation

    SciTech Connect (OSTI)

    Jani, S [Sharp Memorial Hospital, San Diego, CA (United States)

    2014-06-01

    Purpose: CT simulation for patients with metal implants can often be challenging due to artifacts that obscure tumor/target delineation and normal organ definition. Our objective was to evaluate the effectiveness of Orthopedic Metal Artifact Reduction (OMAR), a commercially available software, in reducing metal-induced artifacts and its effect on computed dose during treatment planning. Methods: CT images of water surrounding metallic cylindrical rods made of aluminum, copper and iron were studied in terms of Hounsfield Units (HU) spread. Metal-induced artifacts were characterized in terms of HU/Volume Histogram (HVH) using the Pinnacle treatment planning system. Effects of OMAR on enhancing our ability to delineate organs on CT and subsequent dose computation were examined in nine (9) patients with hip implants and two (2) patients with breast tissue expanders. Results: Our study characterized water at 1000 HU with a standard deviation (SD) of about 20 HU. The HVHs allowed us to evaluate how the presence of metal changed the HU spread. For example, introducing a 2.54 cm diameter copper rod in water increased the SD in HU of the surrounding water from 20 to 209, representing an increase in artifacts. Subsequent use of OMAR brought the SD down to 78. Aluminum produced least artifacts whereas Iron showed largest amount of artifacts. In general, an increase in kVp and mA during CT scanning showed better effectiveness of OMAR in reducing artifacts. Our dose analysis showed that some isodose contours shifted by several mm with OMAR but infrequently and were nonsignificant in planning process. Computed volumes of various dose levels showed <2% change. Conclusions: In our experience, OMAR software greatly reduced the metal-induced CT artifacts for the majority of patients with implants, thereby improving our ability to delineate tumor and surrounding organs. OMAR had a clinically negligible effect on computed dose within tissues. Partially funded by unrestricted educational grant from Philips.

  13. Rice Diseases

    E-Print Network [OSTI]

    Jones, Roger K.

    1987-01-01

    Alzheimer's disease (AD) is the most common form of the dementia in the aging population. ?-amyloid peptide (A?) has been indicated as the most important hallmark of AD and also is believed to be the central trigger of ...

  14. Respiratory effects of diesel exhaust in salt miners

    SciTech Connect (OSTI)

    Gamble, J.F.; Jones, W.G.

    1983-09-01

    The respiratory health of 259 white males working at 5 salt (NaCl) mines was assessed by questionnaire, chest radiographs, and air and He-O/sup 2/ spirometry. Response variables were symptoms, pneumoconiosis, and spirometry. Predictor variables included age, height, smoking, mine, and tenure in diesel-exposed jobs. The purpose was to assess the association of response measures of respiratory health with exposure to diesel exhaust. There were only 2 cases of Grade 1 pneumoconiosis, so no further analysis was done. Comparisons within the study population showed a statistically significant dose-related association of phlegm and diesel exposure. There was a nonsignificant trend for cough and dyspnea, and no association with spirometry. Age- and smoking-adjusted rates of cough, phlegm, and dyspnea were 145, 159, and 93% of an external comparison population. Percent predicted flow rates showed statistically significant reductions, but the reductions were small and there were no dose-response relations. Percent predicted FEV1 and FVC were about 96% of predicted.

  15. SU-E-J-48: Development of An Abdominal Compression Device for Respiratory Correlated Radiation Therapy

    SciTech Connect (OSTI)

    Kim, T; Kang, S; Kim, D; Suh, T [Catholic University Medical College, Seoul (Korea, Republic of); Kim, S [Virginia Commonwealth University, Richmond, VA (United States)

    2014-06-01

    Purpose: The aim of this study is to develop the abdominal compression device which could control pressure level according to the abdominal respiratory motion and evaluate its feasibility. Methods: In this study, we focused on developing the abdominal compression device which could control pressure level at any point of time so the developed device is possible to use a variety of purpose (gating technique or respiratory training system) while maintaining the merit of the existing commercial device. The compression device (air pad form) was designed to be able to compress the front and side of abdomen and the pressure level of the abdomen is controlled by air flow. Pressure level of abdomen (air flow) was determined using correlation data between external abdominal motion and respiratory volume signal measured by spirometer. In order to verify the feasibility of the device, it was necessary to confirm the correlation between the abdominal respiratory motion and respiratory volume signal and cooperation with respiratory training system also checked. Results: In the previous study, we could find that the correlation coefficient ratio between diaphragm and respiratory volume signal measured by spirometer was 0.95. In this study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion measured by belt-transducer (correlation coefficient ratio was 0.92) and used the correlated respiratory volume data as an abdominal pressure level. It was possible to control the pressure level with negligible time delay and respiratory volume data based guiding waveforms could be properly inserted into the respiratory training system. Conclusion: Through this feasibility study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion. Also initial assessment of the device and its compatibility with the respiratory training system were verified. Further study on application in respiratory gated therapy and respiratory training system will be investigated. This work was supported by Radiation Technology R and D program (No. 2013M2A2A7043498)and Basic Atomic Energy Research Institute (BAERI)(No. NRF-2009-0078390) through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning.

  16. Effects of air pollution on children's respiratory health in three Chinese cities

    SciTech Connect (OSTI)

    Qian, Z.; Chapman, R.S.; Tian, Q.; Chen, Y.; Lioy, P.J.; Zhang, J.

    2000-04-01

    During the winter of 1988--1989, parents of 2,789 elementary-school students completed standardized questionnaires. The students were 5--14 y of age and were from three urban districts and one suburban district of three large Chinese cities. The 4-y average ambient levels of total suspended particles in the three cities differed greatly during the period 1985--1988: Lanzhou, 1,067 {micro}g/m{sup 3}; urban Wuhan, 406 {micro}g/m{sup 3}; Guangzhou, 296 {micro}g/m{sup 3}; and suburban Wuhan, 191 {micro}g/m{sup 3}. The authors constructed unconditional logistic-regression models to calculate odds ratios and 95% confidence intervals for prevalences of several respiratory symptoms and illnesses, adjusted for district, use of coal in the home, and parental smoking status. There was a positive and significant association between total suspended particle levels and the adjusted odds ratios for couch, phlegm, hospitalization for diseases, and pneumonia. This association was derived from only the 1,784 urban children and, therefore, the authors were unable to extrapolate it to the suburban children. The results also indicated that parental smoking status was associated with cough and phlegm, and use of coal in the home was associated only with cough prevalence.

  17. Effects of ozone on the respiratory health, allergic sensitization, and cellular immune system in children

    SciTech Connect (OSTI)

    Zwick, H.; Popp, W.; Wagner, C.; Reiser, K.; Schmoeger, J.B.; Boeck, A.H.; Herkner, K.; Radunsky, K. )

    1991-11-01

    To investigate the lasting effects of high ozone concentrations under environmental conditions, we examined the respiratory health, pulmonary function, bronchial hyperresponsiveness to methacholine, allergic sensitization, and lymphocyte subpopulations of 10- to 14-yr-old children. A total of 218 children recruited from an area with high ozone concentrations (Group A) were tested against 281 children coming from an area with low ozone concentrations (Group B). As to subjective complaints, categorized as 'usually cough with or without phlegm,' 'breathlessness,' and 'susceptibility to chest colds,' there was no difference between the two groups. The lung function parameters were similar, but in Group A subjects' bronchial hyperresponsiveness occurred more frequently and was found to be more severe than in Group B (29.4 versus 19.9%, p less than 0.02; PD20 2,100 {plus minus} 87 versus 2,350 {plus minus} 58 micrograms, p less than 0.05). In both groups the number of children who had been suffering from allergic diseases and sensitization to aeroallergens, found by means of the skin test, was the same. Comparison of the total IgE levels showed no difference at all between the two groups. As far as the white blood cells are concerned, the total and differential cell count was the same, whereas lymphocyte subpopulations showed readily recognizable changes.

  18. Pulmonary function and respiratory symptoms in potash workers

    SciTech Connect (OSTI)

    Graham, B.L.; Dosman, J.A.; Cotton, D.J.; Weisstock, S.R.; Lappi, V.G.; Froh, F.

    1984-03-01

    Over 94% of the workers in each of four Saskatchewan potash mines participated in a respiratory health surveillance program that included a questionnaire and pulmonary function tests. Compared with a nonexposed control group, potash workers had higher prevalences of cough, dyspnea, and chronic bronchitis but better pulmonary function. Prevalences of symptoms and pulmonary function abnormalities were similar among workers at the four mines tested and at the various job locations. Potash dust, diesel fumes, and other air contaminants may have an irritant effect that leads to the increased prevalences of cough and chronic bronchitis. Although we found no adverse effects of the potash mine environment on pulmonary function, these findings reflect a healthy worker effect or some selection process that makes the potash workers appear healthier in a cross-sectional study.

  19. Pulmonary function and respiratory symptoms in potash workers

    SciTech Connect (OSTI)

    Graham, B.L.; Dosman, J.A.; Cotton, D.J.; Weisstock, S.R.; Lappi, V.G.; Froh, F.

    1984-03-01

    Over 94% of the workers in each of four Saskatchewan potash mines participated in a respiratory health surveillance program that included a questionnaire and pulmonary function tests. Compared with a nonexposed control group, potash workers had higher prevalences of cough, dyspnea, and chronic bronchitis but better pulmonary function. Prevalences of symptoms and pulmonary function abnormalities were similar among workers at the four mines tested and at the various job locations. Potash dust, diesel fumes, and other air contaminants may have an irritant effect that leads to the increased prevalences of cough and chronic bronchitis. Although no adverse effects of the potash mine environment on pulmonary function were found, these findings reflect a healthy worker effect or some selection process that makes the potash workers appear healthier in a cross-sectional study.

  20. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  1. Nitrogen dioxide and respiratory illness in children. Part I: Health outcomes

    SciTech Connect (OSTI)

    Samet, J.M.; Lambert, W.E.; Skipper, B.J.; Cushing, A.H.; Hunt, W.C.; Young, S.A.; McLaren, L.C.; Schwab, M.; Spengler, J.D. )

    1993-06-01

    We have carried out a prospective cohort study to test the hypothesis that exposure to nitrogen dioxide increases the incidence and severity of respiratory infections during the first 18 months of life. Between January 1988 and June 1990, 1,315 infants were enrolled into the study at birth and followed with prospective surveillance for the occurrence of respiratory infections and monitoring of nitrogen dioxide concentrations in their homes. The subjects were healthy infants from homes without smokers; they were selected with stratification by type of cooking stove at a ratio of four to one for gas and electric stoves. Illness experience was monitored by a daily diary of symptoms completed by the mother and a telephone interview conducted every two weeks. Illnesses with wheezing or wet cough were classified as involving the lower respiratory tract; all other respiratory illnesses were designated as involving the upper respiratory tract. Exposure to nitrogen dioxide was estimated by two-week average concentrations measured in the subjects' bedrooms with passive samplers. This analysis is limited to the 1,205 subjects completing at least one month of observation; of these, 823 completed the full protocol, contributing 82.8% of the total number of days during which the subjects were under observation. Incidence rates for all respiratory illnesses, all upper respiratory illness, all lower respiratory illnesses, and lower respiratory illness further divided into those with any wheezing, or wet cough without wheezing, were examined within strata of nitrogen dioxide exposure at the time of the illness, nitrogen dioxide exposure during the prior month, and type of cooking stove. Consistent trends of increasing illness incidence rates with increasing exposure to nitrogen dioxide were not evident for either the lagged or unlagged exposure variables.

  2. Building-related risk factors and work-related lower respiratory symptoms in 80 office buildings

    SciTech Connect (OSTI)

    Mendell, M.J.; Naco, G.M.; Wilcox, T.G.; Sieber, W.K.

    2002-01-01

    We assessed building-related risk factors for lower respiratory symptoms in office workers. The National Institute for Occupational Safety and Health in 1993 collected data during indoor environmental health investigations of workplaces. We used multivariate logistic regression analyses to assess relationships between lower respiratory symptoms in office workers and risk factors plausibly related to microbiologic contamination. Among 2,435 occupants in 80 office buildings, frequent, work-related multiple lower respiratory symptoms were strongly associated, in multivariate models, with two risk factors for microbiologic contamination: poor pan drainage under cooling coils and debris in outside air intake. Associations tended to be stronger among those with a history of physician-diagnosed asthma. These findings suggest that adverse lower respiratory health effects from indoor work environments, although unusual, may occur in relation to poorly designed or maintained ventilation systems, particularly among previously diagnosed asthmatics. These findings require confirmation in more representative buildings.

  3. Host-virus interactions in porcine reproductive and respiratory syndrome virus infection 

    E-Print Network [OSTI]

    Sorensen, George Edwin Peter

    2014-11-28

    Porcine reproductive and respiratory syndrome virus (PRRSV) is a rapidly evolving virus that has significant economic and welfare implications for the pig industry. Vaccination strategies have proved largely ineffective ...

  4. Impact of Intercurrent Respiratory Infections on Lung Health in Infants Born <29 Weeks with BPD

    E-Print Network [OSTI]

    Taylor, Jane B.

    2013-05-31

    Abstract: Objective: To assess the impact of intercurrent respiratory infections on infants born <29 weeks gestation with bronchopulmonary dysplasia (BPD). Study Design: A retrospective cohort study was conducted on 111 ...

  5. Passive cigarette smoke, coal heating, and respiratory symptoms of nonsmoking women in China

    SciTech Connect (OSTI)

    Pope, C.A. III Brigham Young Univ., Provo, UT ); Xu, X. )

    1993-09-01

    In this study the authors evaluated data from a sample of 973 never-smoking women, ages 20-40, who worked in three similar textile mills in Anhui Province, China. They compared prevalence rates of respiratory symptoms across homes with and without coal heating and homes with different numbers of smokers. Multiple logistic regression models that controlled for age, job title, and mill of employment were also estimated. Respiratory symptoms were associated with combined exposure to passive cigarette smoke and coal heating. Effects of passive cigarette smoke and coal heating on respiratory symptoms appeared to be nearly additive, suggesting a dose-response relationship between respiratory symptoms and home indoor air pollution from these two sources. The prevalence of chest illness, cough, phlegm, and shortness of breath (but not wheeze) was significantly elevated for women living in homes with both smokers and coal heating.

  6. John Widdicombe¿s contribution to respiratory physiology and cough: reminiscences

    E-Print Network [OSTI]

    Chung, Kian Fan; Nadel, Jay A; Fontana, Giovanni

    2013-01-01

    But urge-to-cough is perplexing. I await confirmation orM, Widdicombe J: Fog-induced cough with impaired respiratoryJ: Desensitization of the cough reflex by exercise and

  7. Genomics provides powerful tools in the global effort to combat Severe Acute Respiratory Syndrome (SARS)

    E-Print Network [OSTI]

    Brutlag, Doug

    ; a distressing cough brings up blood stained sputum. In the morning the dead bodies were stacked about the morgue by a nonproductive cough and shortness of breath. Eventually, some died because of progressive respiratory failure

  8. SYNCHROSQUEEZING TO INVESTIGATE CARDIO-RESPIRATORY INTERACTIONS WITHIN SIMULATED VOLUMETRIC SIGNALS

    E-Print Network [OSTI]

    Fontecave-Jallon, Julie

    SYNCHROSQUEEZING TO INVESTIGATE CARDIO-RESPIRATORY INTERACTIONS WITHIN SIMULATED VOLUMETRIC SIGNALS phone: +33 4 56 52 00 60, email: Celine.Franco@imag.fr ABSTRACT The interest of volumetric signals

  9. Association of residential dampness and mold with respiratory tract infections and bronchitis: a meta-analysis

    SciTech Connect (OSTI)

    Fisk, William J.; Eliseeva, Ekaterina A.; Mendell, Mark J.

    2010-11-15

    Dampness and mold have been shown in qualitative reviews to be associated with a variety of adverse respiratory health effects, including respiratory tract infections. Several published meta-analyses have provided quantitative summaries for some of these associations, but not for respiratory infections. Demonstrating a causal relationship between dampness-related agents, which are preventable exposures, and respiratory tract infections would suggest important new public health strategies. We report the results of quantitative meta-analyses of published studies that examined the association of dampness or mold in homes with respiratory infections and bronchitis. For primary studies meeting eligibility criteria, we transformed reported odds ratios (ORs) and confidence intervals (CIs) to the log scale. Both fixed and random effects models were applied to the log ORs and their variances. Most studies contained multiple estimated ORs. Models accounted for the correlation between multiple results within the studies analyzed. One set of analyses was performed with all eligible studies, and another set restricted to studies that controlled for age, gender, smoking, and socioeconomic status. Subgroups of studies were assessed to explore heterogeneity. Funnel plots were used to assess publication bias. The resulting summary estimates of ORs from random effects models based on all studies ranged from 1.38 to 1.50, with 95% CIs excluding the null in all cases. Use of different analysis models and restricting analyses based on control of multiple confounding variables changed findings only slightly. ORs (95% CIs) from random effects models using studies adjusting for major confounding variables were, for bronchitis, 1.45 (1.32-1.59); for respiratory infections, 1.44 (1.31-1.59); for respiratory infections excluding nonspecific upper respiratory infections, 1.50 (1.32-1.70), and for respiratory infections in children or infants, 1.48 (1.33-1.65). Little effect of publication bias was evident. Estimated attributable risk proportions ranged from 8% to 20%. Residential dampness and mold are associated with substantial and statistically significant increases in both respiratory infections and bronchitis. If these associations were confirmed as causal, effective control of dampness and mold in buildings would prevent a substantial proportion of respiratory infections.

  10. Hemolymph lactate levels and respiratory pumping behavior in the marine gastropod, Aplysia californica 

    E-Print Network [OSTI]

    Grech, Doreen Marie

    1988-01-01

    HEMOLYMPH LACTATE LEVELS AND RESPIRATORY PUMPING BEHAVIOR IN THE MARINE GASTROPOD, APLYSIA CALIFORNICA A Thesis by DOREEN MARIE GRECH Submitted to the Graduate College of Texas A & M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1988 Major Subject: Biology HEMOLYMPH LACTATE LEVELS AND RESPIRATORY PUMPING BEHAVIOR IN THE MARINE GASTROPOD, APLYSIA CALIFORNICA A Thesis by DOREEN MARIE GRECH Approved as to style and content by: ames E. K z...

  11. Daily air pollution effects on children's respiratory symptoms and peak expiratory flow

    SciTech Connect (OSTI)

    Vedal, S.; Schenker, M.B.; Munoz, A.; Samet, J.M.; Batterman, S.; Speizer, F.E.

    1987-06-01

    To identify acute respiratory health effects associated with air pollution due to coal combustion, a subgroup of elementary school-aged children was selected from a large cross-sectional study and followed daily for eight months. Children were selected to obtain three equal-sized groups: one without respiratory symptoms, one with symptoms of persistent wheeze, and one with cough or phlegm production but without persistent wheeze. Parents completed a daily diary of symptoms from which illness constellations of upper respiratory illness (URI) and lower respiratory illness (LRI) and the symptom of wheeze were derived. Peak expiratory flow rate (PEFR) was measured daily for nine consecutive weeks during the eight-month study period. Maximum hourly concentrations of sulfur dioxide, nitrogen dioxide, ozone, and coefficient of haze for each 24-hour period, as well as minimum hourly temperature, were correlated with daily URI, LRI, wheeze, and PEFR using multiple regression models adjusting for illness occurrence or level of PEFR on the immediately preceding day. Respiratory illness on the preceding day was the most important predictor of current illness. A drop in temperature was associated with increased URI and LRI but not with increased wheeze or with a decrease in level of PEFR. No air pollutant was strongly associated with respiratory illness or with level of PEFR, either in the group of children as a whole, or in either of the symptomatic subgroups; the pollutant concentrations observed, however, were uniformly lower than current ambient air quality standards.

  12. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. )

    1990-01-01

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  13. Biomarkers of acute respiratory allergen exposure: Screening for sensitization potential

    SciTech Connect (OSTI)

    Pucheu-Haston, Cherie M.; Copeland, Lisa B.; Vallanat, Beena; Boykin, Elizabeth; Ward, Marsha D.W.

    2010-04-15

    Effective hazard screening will require the development of high-throughput or in vitro assays for the identification of potential sensitizers. The goal of this preliminary study was to identify potential biomarkers that differentiate the response to allergens vs non-allergens following an acute exposure in naive individuals. Female BALB/c mice received a single intratracheal aspiration exposure to Metarhizium anisopliae crude antigen (MACA) or bovine serum albumin (BSA) in Hank's Balanced Salt Solution (HBSS) or HBSS alone. Mice were terminated after 1, 3, 6, 12, 18 and 24 h. Bronchoalveolar lavage fluid (BALF) was evaluated to determine total and differential cellularity, total protein concentration and LDH activity. RNA was isolated from lung tissue for microarray analysis and qRT-PCR. MACA administration induced a rapid increase in BALF neutrophils, lymphocytes, eosinophils and total protein compared to BSA or HBSS. Microarray analysis demonstrated differential expression of genes involved in cytokine production, signaling, inflammatory cell recruitment, adhesion and activation in 3 and 12 h MACA-treated samples compared to BSA or HBSS. Further analyses allowed identification of approx 100 candidate biomarker genes. Eleven genes were selected for further assessment by qRT-PCR. Of these, 6 demonstrated persistently increased expression (Ccl17, Ccl22, Ccl7, Cxcl10, Cxcl2, Saa1), while C3ar1 increased from 6-24 h. In conclusion, a single respiratory exposure of mice to an allergenic mold extract induces an inflammatory response which is distinct in phenotype and gene transcription from the response to a control protein. Further validation of these biomarkers with additional allergens and irritants is needed. These biomarkers may facilitate improvements in screening methods.

  14. Are you protected against Pertussis? Pertussis, or whooping cough, is a highly contagious respiratory infection caused by the bacterium

    E-Print Network [OSTI]

    Are you protected against Pertussis? Pertussis, or whooping cough, is a highly contagious respiratory infection caused by the bacterium Bordetella pertussis. It causes severe coughing spells, vomiting

  15. Respiratory health effects of the indoor environment in a population of Dutch children

    SciTech Connect (OSTI)

    Dijkstra, L.; Houthuijs, D.; Brunekreef, B.; Akkerman, I.; Boleij, J.S. )

    1990-11-01

    The effect of indoor exposure to nitrogen dioxide on respiratory health was studied over a period of 2 yr in a population of nonsmoking Dutch children 6 to 12 yr of age. Lung function was measured at the schools, and information on respiratory symptoms was collected from a self-administered questionnaire completed by the parents of the children. Nitrogen dioxide was measured in the homes of all children with Palmes' diffusion tubes. In addition, information on smoking and dampness in the home was collected by questionnaire. There was no relationship between exposure to nitrogen dioxide in the home and respiratory symptoms. Respiratory symptoms were found to be associated with exposure to tobacco smoke and home dampness. There was a weak, negative association between maximal midexpiratory flow (MMEF) and exposure to nitrogen dioxide. FEV1, peak expiratory flow, and MMEF were all negatively associated with exposure to tobacco smoke. Home dampness was not associated with pulmonary function. Lung function growth, measured over a period of 2 yr, was not consistently associated with any of the indoor exposure variables. The development of respiratory symptoms over time was not associated with indoor exposure to nitrogen dioxide. There was a significant association between exposure to environmental tobacco smoke in the home and the development of wheeze. There was also a significant association between home dampness and the development of cough.

  16. Hamilton study: distribution of factors confounding the relationship between air quality and respiratory health

    SciTech Connect (OSTI)

    Pengelly, L.D.; Kerigan, A.T.; Goldsmith, C.H.; Inman, E.M.

    1984-10-01

    Hamilton, Ontario is an industrial city with a population of 300,000 which is situated at the western end of Lake Ontario. Canada's two largest iron and steel mills are located here; the city historically has had relatively poor air quality, which has improved markedly in the last 25 years. Concern about the health effects of current air quality recently led us to carry out an epidemiological study of the effects of air pollution on the respiratory health of over 3500 school children. Respiratory health was measured by pulmonary function testing of each child, and by an assessment of each child's respiratory symptoms via a questionnaire administered to the parents. Previous studies had shown that other environmental factors (e.g. parental smoking, parental cough, socioeconomic level, housing, and gas cooking) might also affect respiratory health, and thus confound any potential relationships between health and air pollution. The questionnaire also collected information on many of these confounding factors. For the purposes of initial analysis, the city was divided into five areas in which differences in air quality were expected. In general, factors which have been associated with poor respiratory health were observed to be more prevalent in areas of poorer air quality.

  17. Gaucher Disease Inherited disorder

    E-Print Network [OSTI]

    Brutlag, Doug

    , spleen, and bone marrow ¡ Many types ¡ Possible link to Parkinson's Disease ¡ Affects 1 in 100,000 #12/> ¡ "Gaucher Disease." Genetics Home Reference ­ Your Guide to Understanding Genetic Conditions. US National Disease." Gene Review. Web 2 Oct. 2012. Genetics

  18. Smoking cessation among coal miners as predicted by baseline respiratory function and symptoms: a 5-year prospective study

    SciTech Connect (OSTI)

    Ames, R.G.; Hall, D.S.

    1985-03-01

    A prospective analysis was used to test whether respiratory impairment or the presence of respiratory symptoms predicts 5-year cigarette smoking cessation in a sample of 1,118 U.S. white, male, underground coal miners. Miners were examined in 1977 and re-examined in 1982 by NIOSH, and all miners with test abnormalities were so informed by letter. Respiratory impairment was measured by an index of airways obstruction combining the spirometric measures of Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 sec (FEV1). Bronchitis symptoms were measured by an index that combined chronic cough (3+ months/year) and chronic phlegm (3 + months/year). Among these coal miners, the presence of chronic respiratory symptoms initially was inversely associated with cigarette smoking cessation. Respiratory impairment, however, was positively associated with cigarette smoking cessation but did not reach statistical significance.

  19. Functional Analyses of the Molecular mechanisms Underlying Two Equine Respiratory Diseases: Recurrent Airway Obstruction and Rhodococcus equi Pneumonia 

    E-Print Network [OSTI]

    Kachroo, Priyanka

    2012-07-16

    ...................................................................................... 111 IV GENE EXPRESSION PROFILING TO ESTABLISH TEMPORAL CHANGES IN PERIPHERAL BLOOD LEUKOCYTES OF HEALTHY FOALS AND FOALS AFFECTED WITH RHODOCOCCUS EQUI PNEUMONIA...-3 Enriched biological process terms in RAO animals compared to control 60 Figure 2-4 GO Term Mapper result .......................................................................... 63 Figure 2-5 Linear discriminant analysis using three-gene...

  20. SU-D-17A-07: Development and Evaluation of a Prototype Ultrasonography Respiratory Monitoring System for 4DCT Reconstruction

    SciTech Connect (OSTI)

    Yan, P; Cheng, S; Chao, C [Columbia University Medical Center, NY, NY (United States); Jain, A [New York Presbyterian Hospital, NY, NY (United States)

    2014-06-01

    Purpose: Respiratory motion artifacts are commonly seen in the abdominal and thoracic CT images. A Real-time Position Management (RPM) system is integrated with CT simulator using abdominal surface as a surrogate for tracking the patient respiratory motion. The respiratory-correlated four-dimensional computed tomography (4DCT) is then reconstructed by GE advantage software. However, there are still artifacts due to inaccurate respiratory motion detecting and sorting methods. We developed an Ultrasonography Respiration Monitoring (URM) system which can directly monitor diaphragm motion to detect respiratory cycles. We also developed a new 4DCT sorting and motion estimation method to reduce the respiratory motion artifacts. The new 4DCT system was compared with RPM and the GE 4DCT system. Methods: Imaging from a GE CT scanner was simultaneously correlated with both the RPM and URM to detect respiratory motion. A radiation detector, Blackcat GM-10, recorded the X-ray on/off and synchronized with URM. The diaphragm images were acquired with Ultrasonix RP system. The respiratory wave was derived from diaphragm images and synchronized with CT scanner. A more precise peaks and valleys detection tool was developed and compared with RPM. The motion is estimated for the slices which are not in the predefined respiratory phases by using block matching and optical flow method. The CT slices were then sorted into different phases and reconstructed, compared with the images reconstructed from GE Advantage software using respiratory wave produced from RPM system. Results: The 4DCT images were reconstructed for eight patients. The discontinuity at the diaphragm level due to an inaccurate identification of phases by the RPM was significantly improved by URM system. Conclusion: Our URM 4DCT system was evaluated and compared with RPM and GE 4DCT system. The new system is user friendly and able to reduce motion artifacts. It also has the potential to monitor organ motion during therapy.

  1. Respiratory gating of anatomical optical coherence tomography images of the human

    E-Print Network [OSTI]

    Daume III, Hal

    , N. Zamel, and V. Hoffstein, "Pharyngeal cross-sectional area in normal men and women," J. Appl. Physiol. 61, 890-895 (1986). 8. P. P. Hsu, H. N. C. Han, Y. H. Chan, H. N. Tay, R. H. Brett, P. K. S. Lu demonstration of respiratory gating of aOCT airway data, and introduces a novel error measure to guide

  2. Extraction of Direct Respiratory Influences from the Tachogram using Multiscale Principal Component Analysis

    E-Print Network [OSTI]

    Leuven, Belgium; Abstract Heart rate variability (HRV) studies are widely used to assess the functioning of the autonomic nervous system. Due to respiratory influences in the tachogram, the interpretation of HRV mea Sinus Arrhythmia 1 Introduction Heart rate variability (HRV) analysis is widely used to gain insights

  3. Correspondence www.thelancet.com/respiratory Vol 3 March 2015 e7

    E-Print Network [OSTI]

    Handel, Andreas

    the study; JB reports grants from Pfizer, outside of the submitted work. RW reports receiving grantsCorrespondence www.thelancet.com/respiratory Vol 3 March 2015 e7 report the number of participants between intervention groups in each socioeconomic status subsample). Although we did not report

  4. Theoretical evaluation on burn injury of human respiratory tract due to inhalation of

    E-Print Network [OSTI]

    Zhang, Jun

    at tissue temperature (kPa) mQ Metabolic rate of tissue (W/m3 ) R Ideal gas constant (J/molK) Re Reynolds1 Theoretical evaluation on burn injury of human respiratory tract due to inhalation of hot gas to predict the thermal impact of inhaled hot air during the early stage of fires. Influences of individual

  5. Techniques in Whole Animal Respiratory Physiology JJ Cech Jr., University of California, Davis, CA, USA

    E-Print Network [OSTI]

    Wood, Spencer

    influenced by environmental temperature and so it is not always constant within an individual. Swimming The pressure that a component of a gas mixture would have if it alone occupied the same volume at the same The movement of the respiratory medium (air or water) over the surface of the gas exchanger. Ventilation volume

  6. Modeling Respiratory Lung Motion a Biophysical Approach using Finite Element Methods

    E-Print Network [OSTI]

    Lübeck, Universität zu

    Modeling Respiratory Lung Motion ­ a Biophysical Approach using Finite Element Methods Rene Wernera motion gains in importance. In this paper a biophysical approach for modeling lung motion is described. Main aspects of the process of lung ventilation are identified and outlined as the starting point

  7. Respiratory Physiology & Neurobiology 131 (2002) 233243 Relative motion of lung and chest wall promotes uniform

    E-Print Network [OSTI]

    Federspiel, William J.

    2002-01-01

    Respiratory Physiology & Neurobiology 131 (2002) 233­243 Relative motion of lung and chest wall, USA b Artificial Lung Program, Uni6ersity of Pittsburgh, Pittsburgh, PA 15260, USA c Department of lung par- enchyma and effective inspiratory action of the diaphragm, the lungs and chest wall must

  8. Personal exposure to nitrogen dioxide and its association with respiratory illness in Hong Kong

    SciTech Connect (OSTI)

    Koo, L.C.; Ho, J.H.; Ho, C.Y.; Matsuki, H.; Shimizu, H.; Mori, T.; Tominaga, S. )

    1990-05-01

    In 1985, 362 primary schoolchildren and their 319 mothers were surveyed in Hong Kong to study the possible relationship of air pollution to respiratory illnesses. Using nitrogen dioxide (NO{sub 2}) measured by personal samplers as a measure of air pollution, the study aimed to identify the major sources of NO{sub 2} in the indoor environment and see whether its increased presence was associated with respiratory symptoms. The levels of NO{sub 2} among the mothers was found to increase by 21% if dust exposure was reported from the workplace, 18% if they used such cooking fuels as liquid petroleum gas or kerosene, 11% when kitchens did not have ventilating fans, and 10% when incense was burned at home. In terms of respiratory symptoms, an increase in NO{sub 2} levels of 19% was reported among those with allergic rhinitis and 18% among those with chronic cough. The levels of NO2 among children were correlated with levels measured in classrooms, all of which had opened windows so that the NO{sub 2} came from outdoors. No association was found between children's NO{sub 2} levels and respiratory symptoms. With the exception of smoking by the father and the children's NO{sub 2} levels, no association was found between smoking at home and NO{sub 2} levels.

  9. Pulmonary function and respiratory symptoms of school children exposed to ambient air pollution

    SciTech Connect (OSTI)

    Kim, Yoon Shin; Ko, Ung Ring

    1996-12-31

    This study was undertaken to evaluate the health effect of air pollution on pulmonary function and respiratory symptoms of Korean school children between 7 and 10 years of age during November 1995-January 1996. A standard respiratory symptom questionnaire was administered and spirometry was performed to examine pulmonary function of 121 children in an urban polluted area, Seoul, and of 119 children in non-polluted area, Sokcho, respectively. There was significant difference in the level of pulmonary function [forced expiratory volume in second (FEV{sub 1.0}) and forced vital capacity (FVC)] between exposed groups to polluted area and non-polluted area. Parental smoking was significantly related to respiratory symptoms of cough, phlegm, and the level of pulmonary function. The observed changes in FEV{sub 1.0} and FVC seemed to relate to home cooking fuel, not to respiratory symptoms. The additional longitudinal work that carefully monitors ambient and indoor air pollution and health effects data should be conducted to confirm these results.

  10. Prevalence of respiratory symptoms and cases suspicious for tuberculosis among public health clinic patients in Afghanistan,

    E-Print Network [OSTI]

    Scharfstein, Daniel

    , and diagnostic test results were recorded. Correlates of TB-suggestive symptoms (defined as cough >2 weeks children (age 17 or under). The TB-suggestive symptoms of cough >2 weeks and / or haemoptysis were reported workers. keywords Afghanistan, tuberculosis, respiratory symptoms, cough, sputum smear accuracy

  11. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  12. Understanding Heart Disease

    E-Print Network [OSTI]

    Shen, Jun

    1 Understanding Heart Disease Vietnamese Aspire For Healthy Hearts What Is Heart Disease? Heart the blood vessels going to the heart become narrow and clogged. Blood vessels are long, hollow tubes arteries. When arteries become clogged, it increases the risk of developing heart disease. When the heart

  13. A cross-sectional study of secondhand smoke exposure and respiratory symptoms in non-current smokers in the U.S. trucking industry: SHS exposure and respiratory symptoms

    E-Print Network [OSTI]

    Laden, Francine; Chiu, Yueh-Hsiu; Garshick, Eric; Hammond, S; Hart, Jaime E

    2013-01-01

    with chronic phlegm, chronic cough, and any wheeze, defined= 1.00- 2.13) for chronic cough, 1.55 (95% CI = 1.08-2.21)respiratory symptoms, including cough, phlegm and wheeze, in

  14. Insights into the respiratory tract microbiota of patients with cystic fibrosis during early Pseudomonas aeruginosa colonization

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Keravec, Marlène; Mounier, Jérôme; Prestat, Emmanuel; Vallet, Sophie; Jansson, Janet K.; Burgaud, Gaëtan; Rosec, Sylvain; Gouriou, Stéphanie; Rault, Gilles; Coton, Emmanuel; et al

    2015-08-09

    Pseudomonas aeruginosa plays a major role in cystic fibrosis (CF) progression. Therefore, it is important to understand the initial steps of P. aeruginosa infection. The structure and dynamics of CF respiratory tract microbial communities during the early stages of P. aeruginosa colonization were characterized by pyrosequencing and cloning-sequencing. The respiratory microbiota showed high diversity, related to the young age of the CF cohort (mean age 10 years). Wide inter- and intra-individual variations were revealed. A common core microbiota of 5 phyla and 13 predominant genera was found, the majority of which were obligate anaerobes. A few genera were significantly moremore »prevalent in patients never infected by P. aeruginosa. Persistence of an anaerobic core microbiota regardless of P. aeruginosa status suggests a major role of certain anaerobes in the pathophysiology of lung infections in CF. Some genera may be potential biomarkers of pulmonary infection state.« less

  15. Respiratory symptoms and lung function in oil mist-exposed workers

    SciTech Connect (OSTI)

    Jarvholm, B.; Bake, B.; Lavenius, B.; Thiringer, G.; Vokmann, R.

    1982-06-01

    The prevalence of respiratory symptoms was registered and ventilatory function was determined in 164 men exposed to oil mist. The average exposure time was 16.2 years. One hundred fifty-nine office workers served as controls. The exposed men reported more respiratory symptoms: 14% of the exposed nonsmokers v. 2% of the nonsmoking controls having cough at least three months a year. There were non significant differences between spirometric measurements and chest roentgenograms of the men exposed to oil mist and those of the office workers. The lung function of 25 nonsmoking exposed men was further examined with other lung function tests. The mean values for closing volume, slope of the alveolar plateau, total lung capacity, residual volume, elastic recoil at various lung volumes, and diffusion capacity did not differ significantly.

  16. Mass-transport models to predict toxicity of inhaled gases in the upper respiratory tract

    SciTech Connect (OSTI)

    Hubal, E.A.C.; Fedkiw, P.S.; Kimbell, J.S. [North Carolina State Univ., Raleigh, NC (United States)

    1996-04-01

    Mass-transport (the movement of a chemical species) plays an important role in determining toxic responses of the upper respiratory tract (URT) to inhaled chemicals. Mathematical dosimetry models incorporate physical characteristics of mass transport and are used to predict quantitative uptake (absorption rate) and distribution of inhaled gases and vapors in the respiratory tract. Because knowledge of dose is an essential component of quantitative risk assessment, dosimetry modeling plays an important role in extrapolation of animal study results to humans. A survey of existing mathematical dosimetry models for the URT is presented, limitations of current models are discussed, and adaptations of existing models to produce a generally applicable model are suggested. Reviewed URT dosimetry models are categorized as early, lumped-parameter, and distributed-parameter models. Specific examples of other relevant modeling work are also presented. 35 refs., 11 figs., 1 tab.

  17. The Department of Energy Respiratory Acceptance Program for Supplied-Air Suits

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-02-04

    The supplied-air suits that protect DOE contractor and federal employees from exposure to harmful atmospheres and radioactive contaminants are not included in the National Institute for Occupational Safety and Health (NIOSH) certification process for respiratory protective devices. Therefore, with the awareness and acknowledgement of NIOSH and the Occupational Safety and Health Administration (OSHA), the Department established a system for acceptance testing of supplied-air suits.

  18. Rapid Reagentless Detection of M. tuberculosis H37Ra in Respiratory Effluents

    SciTech Connect (OSTI)

    Adams, K L; Steele, P T; Bogan, M J; Sadler, N M; Martin, S; Martin, A N; Frank, M

    2008-01-29

    Two similar mycobacteria, Mycobacteria tuberculosis H37Ra and Mycobacteria smegmatis are rapidly detected and identified within samples containing a complex background of respiratory effluents using Single Particle Aerosol Mass Spectrometry (SPAMS). M. tuberculosis H37Ra (TBa), an avirulent strain, is used as a surrogate for virulent tuberculosis (TBv); M. smegmatis (MSm) is utilized as a near neighbor confounder for TBa. Bovine lung surfactant and human exhaled breath condensate are used as first-order surrogates for infected human lung expirations from patients with pulmonary tuberculosis. This simulated background sputum is mixed with TBa or MSm and nebulized to produce conglomerate aerosol particles, single particles that contain a bacterium embedded within a background respiratory matrix. Mass spectra of single conglomerate particles exhibit ions associated with both respiratory effluents and mycobacteria. Spectral features distinguishing TBa from MSm in pure and conglomerate particles are shown. SPAMS pattern matching alarm algorithms are able to distinguish TBa containing particles from background matrix and MSm for >50% of the test particles, which is sufficient to enable a high probability of detection and a low false alarm rate if an adequate number of such particles are present. These results indicate the potential usefulness of SPAMS for rapid, reagentless tuberculosis screening.

  19. SU-E-J-261: Statistical Analysis and Chaotic Dynamics of Respiratory Signal of Patients in BodyFix

    SciTech Connect (OSTI)

    Michalski, D; Huq, M; Bednarz, G; Lalonde, R; Yang, Y; Heron, D [University of Pittsburgh Medical Center, Pittsburgh, PA (United States)

    2014-06-01

    Purpose: To quantify respiratory signal of patients in BodyFix undergoing 4DCT scan with and without immobilization cover. Methods: 20 pairs of respiratory tracks recorded with RPM system during 4DCT scan were analyzed. Descriptive statistic was applied to selected parameters of exhale-inhale decomposition. Standardized signals were used with the delay method to build orbits in embedded space. Nonlinear behavior was tested with surrogate data. Sample entropy SE, Lempel-Ziv complexity LZC and the largest Lyapunov exponents LLE were compared. Results: Statistical tests show difference between scans for inspiration time and its variability, which is bigger for scans without cover. The same is for variability of the end of exhalation and inhalation. Other parameters fail to show the difference. For both scans respiratory signals show determinism and nonlinear stationarity. Statistical test on surrogate data reveals their nonlinearity. LLEs show signals chaotic nature and its correlation with breathing period and its embedding delay time. SE, LZC and LLE measure respiratory signal complexity. Nonlinear characteristics do not differ between scans. Conclusion: Contrary to expectation cover applied to patients in BodyFix appears to have limited effect on signal parameters. Analysis based on trajectories of delay vectors shows respiratory system nonlinear character and its sensitive dependence on initial conditions. Reproducibility of respiratory signal can be evaluated with measures of signal complexity and its predictability window. Longer respiratory period is conducive for signal reproducibility as shown by these gauges. Statistical independence of the exhale and inhale times is also supported by the magnitude of LLE. The nonlinear parameters seem more appropriate to gauge respiratory signal complexity since its deterministic chaotic nature. It contrasts with measures based on harmonic analysis that are blind for nonlinear features. Dynamics of breathing, so crucial for 4D-based clinical technologies, can be better controlled if nonlinear-based methodology, which reflects respiration characteristic, is applied. Funding provided by Varian Medical Systems via Investigator Initiated Research Project.

  20. Wheat Diseases Atlas. 

    E-Print Network [OSTI]

    McCoy, Norman L.; Berry, Robert W.

    1982-01-01

    to wheat producers over the state on whose farms demonstrations have been conducted and pic tures for this publication were made. WhEAT DisEASES ATLAs Norman L. McCoy and Robert W Berry* INTRODUCTION Wheat diseases have caused untold human suffer ing...

  1. Air pollution and childhood respiratory health: Exposure to sulfate and ozone in 10 Canadian Rural Communities

    SciTech Connect (OSTI)

    Stern, B.R.; Raizenne, M.E.; Burnett, R.T.; Jones, L.; Kearney, J.; Franklin, C.A. )

    1994-08-01

    This study was designed to examine differences in the respiratory health status of preadolescent school children, aged 7-11 years, who resided in 10 rural Canadian communities in areas of moderate and low exposure to regional sulfate and ozone pollution. Five of the communities were located in central Saskatchewan, a low-exposure region, and five were located in southwestern Ontario, an area with moderately elevated exposures resulting from long-range atmospheric transport of polluted air masses. In this cross-sectional study, the child's respiratory symptoms and illness history were evaluated using a parent-completed questionnaire, administered in September 1985. Respiratory function was assessed once for each child in the schools between October 1985 and March 1986, by the measurement of pulmonary function for forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV[sub 1.0]), peak expiratory flow rate (PEFR), mean forced expiratory flow rate during the middle half of the FVC curve (FEF[sub 25-75]), and maximal expiratory flow at 50% of the expired vital capacity (V[sub 50]max). After controlling for the effects of age, sex, parental smoking, parental education and gas cooking, no significant regional differences were observed in rates of chronic cough or phlegm, persistent wheeze, current asthma, bronchitis in the past year, or any chest illness that kept the child at home for 3 or more consecutive days during the previous year. Children living in southwestern Ontario had statistically significant (P < 0.01) mean decrements of 1.7% in FVC and 1.3% in FEV[sub 1.0] compared with Saskatchewan children, after adjusting for age, sex, weight, standing height, parental smoking, and gas cooking. There were no statistically significant regional differences in the pulmonary flow parameters (P > 0.05). 54 refs., 1 fig., 7 tabs.

  2. International Scholarly Research Network ISRN Orthopedics

    E-Print Network [OSTI]

    Azad, Abdul-Majeed

    in wound healing. In this work, TiO2 nanofibers were synthesized by electrospinning. Doping with iron

  3. Orthopedic Correction of Growing Retrognathic Hyperdivergent Patients 

    E-Print Network [OSTI]

    Carrillo, Roberto

    2014-05-13

    The purpose of this prospective study was to determine whether dental intrusion is effective in treating growing retrognathic hyperdivergent patients without negatively affecting the roots and periodontal structures. The ...

  4. Nitric oxide and carbon monoxide in cigarette smoke in the development of cardiorespiratory disease in smokers

    E-Print Network [OSTI]

    Borland, Colin David Ross

    1988-10-18

    in the Department of Respiratory Physiology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ. 2) The practical work was all performed by me excepting as follows. In Chapter 6 Karen Harmes ESc p~rformed the methaemoglobin analyses. In Chapter 5(2) Rachel... as to atmospheric po llution (Reid and Fletcher 1971) . Genetic susceptibility to obstructive lung disease, e.g. a 1 antitrypsin defic iency (Kueppers and Black 1974) is well recognised but it affects only a s mall proportion of s mokers. The relat ionshi p...

  5. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  6. Chronic obstructive pulmonary disease, pulmonary function and cardiovascular disease 

    E-Print Network [OSTI]

    McAllister, David Anthony

    2011-07-05

    Cardiovascular disease is common in Chronic Obstructive Pulmonary Disease (COPD), and forced expiratory volume in one second (FEV1) independently predicts cardiovascular morbidity and mortality. Pathological changes in ...

  7. Acute and chronic respiratory lesions induced by sulfur mustard in guinea pigs: Role of tachykinins

    SciTech Connect (OSTI)

    Calvet, J.H.; Trouiller, G.; Harf, A.

    1993-05-13

    We investigated in anesthetized guinea pigs the involvement of tachykinins in respiratory alterations after an airway intoxication by sulfur mustard (SM). Early lesions were evaluated after 5h. Respiratory system resistance (R) and compliance were measured by the occlusion method and airway microvascular permeability by measuring the Evans Blue dye concentration in the trachea and main bronchi. Two groups of animals were studied treated with capsaicin (which induces a tachykinin depletion) or by its vehicle. Capsaicin pretreatment had no effect on the measured parameters. We also measured 14 J after the intoxication tracheal epithelium neutral endopeptidase (NEP) (the main enzyme which degrades tachykinins). In addition bronchial responsiveness to exogenous substance P was studied in two groups of animals intoxicated with SM or not. Tracheal epithelium NEP activity was decreased from 0.448 + or 0.027 nmol.min- 1.mg protein- 1 in controls to 0. 182 + or 0.038 in intoxicated animals. Response to substance P was greater in intoxicated animals with R=2.98 + or - 1.57 cmH20.MI-1.s versus 0.35 + or 0.02 in controls, after 5.10-5 M aerosolized substance P These results suggest tachykinins are not preponderant in the early stage lesions but that bronchial hyperactivity is present at recovery, related to epithelium NEP depletion.

  8. Absence of respiratory effects in subjects exposed to low concentrations of TDI and MDI

    SciTech Connect (OSTI)

    Musk, A.W.; Peters, J.M.; DiBerardinis, L.; Murphy, R.L.

    1982-10-01

    One hundred seven subjects from a polyurethane plastic manufacturing plant have been followed over a five-year period with measurements of forced expiratory volume in 1 s (FEV1), and questionnaires on respiratory symptoms and smoking habits. Environmental concentrations of toluene diisocyanate and diphenyl methyl diisocyanate were extensively monitored to provide accurate estimates of the upper-limits of exposure of the subjects. Current mean levels of FEV1 in this population were higher than those predicted for healthy subjects. The five-year change in FEV1 did not exceed that expected from aging. No acute change in FEV1 could be demonstrated over the course of a Monday either before or after a two-week vacation. No improvement in ventilatory function was observed over the vacation period. The presence of cough or sputum was related to smoking but was not related to isocyanate exposure. The results indicate that exposure of workers to extremely low levels of isocyanates (time-weighted average concentrations of the order of 0.001 parts per million (ppm)) is not associated with chronic respiratory symptoms or effects on ventilatory capacity. The results suggest that isocyanates can be controlled to the point of eliminating effects as measured by these techniques.

  9. A patient-specific respiratory model of anatomical motion for radiation treatment planning

    E-Print Network [OSTI]

    Zhang, Qinghui; Hertanto, Agung; Hu, Yu-Chi; Rosenzweig, Kenneth E; Ling, C Clifton; Mageras, Gig S

    2007-01-01

    Modeling of respiratory motion is important for a more accurate understanding and accounting of its effect on dose to cancers in the thorax and abdomen by radiotherapy. We have developed a model of respiration-induced organ motion in the thorax, without the commonly adopted assumption of repeatable breath cycles. The model describes the motion of a volume of interest within the patient, based on a reference 3-dimensional image (at end-expiration), and the diaphragm positions at different time points. The input data are respiration-correlated CT images of patients treated for nonsmall cell lung cancer, consisting of 3D images, including the diaphragm positions, at 10 phases of the respiratory cycle. A deformable image registration algorithm calculates the deformation field that maps each 3D image to the reference 3D image. A principle component analysis is performed to parameterize the 3D deformation field in terms of the diaphragm motion. We show that the first two principal components are adequate to accurat...

  10. Respiratory responses of vigorously exercising children to 0. 12 ppm ozone exposure

    SciTech Connect (OSTI)

    McDonnell, W.F. 3d.; Chapman, R.S.; Leigh, M.W.; Strope, G.L.; Collier, A.M.

    1985-10-01

    Changes in respiratory function have been suggested for children exposed to less than 0.12 ppm ozone (O3) while engaged in normal activities. Because the results of these studies have been confounded by other variables, such as temperature or the presence of other pollutants or have been questioned as to the adequacy of exposure measurements, the authors determined the acute response of children exposed to 0.12 ppm O3 in a controlled chamber environment. Twenty-three white males 8 to 11 yr of age were exposed once to clean air and once to 0.12 ppm O3 in random order. Exposures were for 2.5 h and included 2 h of intermittent heavy exercise. Measures of forced expiratory volume in one second (FEV1) and the symptom cough were determined prior to and after each exposure. A significant decline in FEV1 was found after the O3 exposure compared to the air exposure, and it appeared to persist for 16 to 20 h. No significant increase in cough was found due to O3 exposure. Forced vital capacity, specific airways resistance, respiratory frequency, tidal volume, and other symptoms were measured in a secondary exploratory analysis of this study.

  11. Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children

    SciTech Connect (OSTI)

    Neas, L.M.; Dockery, D.W.; Ware, J.H.; Spengler, J.D.; Speizer, F.E.; Ferris, B.G. Jr. )

    1991-07-15

    The effect of indoor nitrogen dioxide on the cumulative incidence of respiratory symptoms and pulmonary function level was studied in a cohort of 1,567 white children aged 7-11 years examined in six US cities from 1983 through 1988. Week-long measurements of nitrogen dioxide were obtained at three indoor locations over 2 consecutive weeks in both the winter and the summer months. The household annual average nitrogen dioxide concentration was modeled as a continuous variable and as four ordered categories. Multiple logistic regression analysis of symptom reports from a questionnaire administered after indoor monitoring showed that a 15-ppb increase in the household annual nitrogen dioxide mean was associated with an increased cumulative incidence of lower respiratory symptoms (odds ratio (OR) = 1.4, 95% confidence interval (95% Cl) 1.1-1.7). The response variable indicated the report of one or more of the following symptoms: attacks of shortness of breath with wheeze, chronic wheeze, chronic cough, chronic phlegm, or bronchitis. Girls showed a stronger association (OR = 1.7, 95% Cl 1.3-2.2) than did boys (OR = 1.2, 95% Cl 0.9-1.5). An analysis of pulmonary function measurements showed no consistent effect of nitrogen dioxide. These results are consistent with earlier reports based on categorical indicators of household nitrogen dioxide sources and provide a more specific association with nitrogen dioxide as measured in children's homes.

  12. Respiratory symptoms among glass bottle makers exposed to stannic chloride solution and other potentially hazardous substances

    SciTech Connect (OSTI)

    Levy, B.S.; Davis, F.; Johnson, B.

    1985-04-01

    Concern about upper respiratory tract irritation and other symptoms among workers at a glass bottle manufacturing plant led to an epidemiologic and an industrial hygiene survey. Questionnaire responses from 35 hot end and 53 cold end workers indicated that the incidence of wheezing, chest pain, dyspnea on exertion, and cough was significantly elevated among hot end workers. Among both smokers and nonsmokers, hot end workers reported higher, but not significantly higher, rates of wheezing and chest pain. Among smokers, hot end workers reported significantly higher rates of dyspnea on exertion and cough than did cold end workers. Data suggest that reported exposure to stannic chloride solution likely caused these symptoms. The industrial hygiene survey, conducted when stannic chloride use had been reduced, cleaning had been done, and ventilation improved, focused on measuring air contaminants that might possibly cause symptoms. Levels of hydrogen chloride, which apparently was formed by the combination of stannic chloride and water in the presence of heat, were elevated. The finding of increased prevalence of respiratory symptoms among hot end workers was consistent with this exposure. Recommendations were made to reduce hazardous exposures at this plant. Individuals responsible for occupational health should be aware that relatively benign substances, such as stannic chloride and water, can combine spontaneously to form hazardous substances.

  13. Health effects of acid aerosols on North American children: Respiratory symptoms

    SciTech Connect (OSTI)

    Dockery, D.W. |; Cunningham, J.; Damokosh, A.I.

    1996-05-01

    We examined the respiratory health effects of exposure to acidic air pollution among 13,369 white children 8 to 12 years old from 24 communities in the United States and Canada between 1988 and 1991. Each child`s parent or guardian completed a questionnaire. Air quality and meteorology were measured in each community for a 1-year period. We used a two-stage logistic regression model to analyze the data, adjusting for the period confounding effects of sex, history of allergies, parental asthma, parental education, and current smoking in the home. Children living in the community with the highest levels of particle strong acidity were significantly more likely [odds ratio (OR) = 1.66; 95% confidence interval (CI) 1.11-2.48] to report at least one episode of bronchitis in the past year compared to children living in the least-polluted community. Fine particulate sulfate was also associated with higher reporting of bronchitis (OR = 1.65; 95% CI 1.12-2.42). No other respiratory symptoms were significantly higher in association with any of the air pollutants of interest. No sensitive subgroups were identified. Reported bronchitis, but neither asthma, wheeze, cough, nor phlegm, were associated with levels of particle strong acidity for these children living in a nonurban environment. 26 refs., 3 figs., 4 tabs.

  14. Osteocytes and Bone Diseases 

    E-Print Network [OSTI]

    Ren, Yinshi

    2015-05-06

    For many centuries, the osteoblast is considered to be responsible for bone formation. It is also believed that an imbalance of osteoblasts (weak) and osteoclasts (strong) is the main cause for bone diseases such as ...

  15. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  16. Soybean Diseases Atlas. 

    E-Print Network [OSTI]

    Anonymous,

    1979-01-01

    new disease which causes root and stem rot to soybeans and other legumes in several southern states. The earliest sympt om is yellowing of leaves of individual plants or patches of plants across fields. Leaves of damaged plants usually develop... new soybean disease restricts root development and causes an absence of nitrogen-fixing nodules. Plants are stunted in an irregular pattern that may resemble manganese toxicity, or moisture or potash deficiency. High nematode populations often...

  17. SU-E-J-45: Design and Study of An In-House Respiratory Gating Phantom Platform for Gated Radiotherapy

    SciTech Connect (OSTI)

    Senthilkumar, S

    2014-06-01

    Purpose: The main purpose of this work was to develop an in-house low cost respiratory motion phantom platform for testing the accuracy of the gated radiotherapy system and analyze the dosimetric difference during gated radiotherapy. Methods: An in-house respiratory motion platform(RMP) was designed and constructed for testing the targeting accuracy of respiratory tracking system. The RMP consist of acrylic Chest Wall Platform, 2 DC motors, 4 IR sensors, speed controller circuit, 2 LED and 2 moving rods inside the RMP. The velocity of the movement can be varied from 0 to 30 cycles per minute. The platform mounted to a base using precision linear bearings. The base and platform are made of clear, 15mm thick polycarbonate plastic and the linear ball bearings are oriented to restrict the platform to a movement of approximately 50mm up and down with very little friction. Results: The targeting accuracy of the respiratory tracking system was evaluated using phantom with and without respiratory movement with varied amplitude. We have found the 5% dose difference to the PTV during the movement in comparison with stable PTV. The RMP can perform sinusoidal motion in 1D with fixed peak to peak motion of 5 to 50mm and cycle interval from 2 to 6 seconds. The RMP was designed to be able to simulate the gross anatomical anterior posterior motion attributable to respiration-induced motion of the thoracic region. Conclusion: The unique RMP simulates breathing providing the means to create a comprehensive program for commissioning, training, quality assurance and dose verification of gated radiotherapy treatments. Create the anterior/posterior movement of a target over a 5 to 50 mm distance to replicate tumor movement. The targeting error of the respiratory tracking system is less than 1.0 mm which shows suitable for clinical treatment with highly performance.

  18. Effectiveness of external respiratory surrogates for in vivo liver motion estimation

    SciTech Connect (OSTI)

    Chang, Kai-Hsiang; Ho, Ming-Chih; Yeh, Chi-Chuan; Chen, Yu-Chien; Lian, Feng-Li; Lin, Win-Li; Yen, Jia-Yush; Chen, Yung-Yaw [Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan (China); Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 10041, Taiwan (China); Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan (China); Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan (China); Institute of Biomedical Engineering, National Taiwan University, Taipei 10041, Taiwan (China); Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan (China); Department of Electrical Engineering and Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan (China)

    2012-08-15

    Purpose: Due to low frame rate of MRI and high radiation damage from fluoroscopy and CT, liver motion estimation using external respiratory surrogate signals seems to be a better approach to track liver motion in real-time for liver tumor treatments in radiotherapy and thermotherapy. This work proposes a liver motion estimation method based on external respiratory surrogate signals. Animal experiments are also conducted to investigate related issues, such as the sensor arrangement, multisensor fusion, and the effective time period. Methods: Liver motion and abdominal motion are both induced by respiration and are proved to be highly correlated. Contrary to the difficult direct measurement of the liver motion, the abdominal motion can be easily accessed. Based on this idea, our study is split into the model-fitting stage and the motion estimation stage. In the first stage, the correlation between the surrogates and the liver motion is studied and established via linear regression method. In the second stage, the liver motion is estimated by the surrogate signals with the correlation model. Animal experiments on cases of single surrogate signal, multisurrogate signals, and long-term surrogate signals are conducted and discussed to verify the practical use of this approach. Results: The results show that the best single sensor location is at the middle of the upper abdomen, while multisurrogate models are generally better than the single ones. The estimation error is reduced from 0.6 mm for the single surrogate models to 0.4 mm for the multisurrogate models. The long-term validity of the estimation models is quite satisfactory within the period of 10 min with the estimation error less than 1.4 mm. Conclusions: External respiratory surrogate signals from the abdomen motion produces good performance for liver motion estimation in real-time. Multisurrogate signals enhance estimation accuracy, and the estimation model can maintain its accuracy for at least 10 min. This approach can be used in practical applications such as the liver tumor treatment in radiotherapy and thermotherapy.

  19. Associations of symptoms related to isocyanate, ureaformol, and formophenolic exposures with respiratory symptoms and lung function in coal miners

    SciTech Connect (OSTI)

    Bertrand, J.P.; Simon, V.; Chau, N.

    2007-04-15

    The respiratory effects of diphenylmethane diisocyanate (MDI)-based resins and ureaformol- and formophenolic-based resins, used in coal mining, are unknown. This cross-sectional study of 354 miners evaluated respiratory health in miners with MDI-related symptoms (IS) and ureaformol/formophenolic-related symptoms (UFS). The protocol included clinical examination, chest radiograph, questionnaire on respiratory symptoms, smoking habit, job history, resin handling, and spirometry. Resin handling concerned 27.7% of the miners. IS affected 5.6%, and 1.4% also after work. UFS affected 22.6%, and 2.3% also after work. Wheezing affected 35.6%; chronic cough, expectoration, or bronchitis about 10%; dyspnea 5.4%; and asthma 2.8%. The miners with UFS had significantly more frequent chronic cough, expectoration, chronic bronchitis, dyspnea, and wheezing, whereas those with IS at and after work had markedly lower FVC, FEV1, MMEF, FEF50% and FEF25%. These findings raise the possibility of deleterious effects of exposures to MDI and ureaformol/ ormophenolic resins on respiratory health and lung function in coal miners during their working life.

  20. Effects of ambient ozone on respiratory function and symptoms in Mexico City schoolchildren

    SciTech Connect (OSTI)

    Castillejos, M.; Gold, D.R.; Dockery, D.; Tosteson, T.; Baum, T.; Speizer, F.E. )

    1992-02-01

    The effects of ambient ozone (O3) on respiratory function and acute respiratory symptoms were evaluated in 143 7- to 9-yr-old schoolchildren followed longitudinally at 1- to 2-wk intervals over a period of 6 months at three schools in Pedregal, Mexico City. The maximum O3 level exceeded the World Health Organization guideline of 80 ppb and the U.S. standard of 120 ppb in every week. For an increase from lowest to highest in the mean O3 level during the 48 hr before spirometry (53 ppb), logistic regression estimated relative odds of 1.7 for a child reporting cough/phlegm on the day of spirometry. For the full population, the mean O3 level during the hour before spirometry, not adjusted for temperature and humidity, predicted a significant decrement in FVC but not in FEV1 or FEF25-75. In contrast, the mean O3 level during the previous 24-, 48-, and 168-h periods predicted significant decrements in FEV1 and FEF25-75 but not in FVC. Ozone was consistently associated with a greater decrement in lung function for the 15 children with chronic phlegm as compared with the children without chronic cough, chronic phlegm, or wheeze. Ozone in the previous 24-, 48-, and 168-h periods predicted decrements in FEV1 for children of mothers who were current or former smokers, but not for children of mothers who were never smokers. Many of these effects were reduced in multiple regression analyses including temperature and humidity, as temperature and O3 were highly correlated.

  1. Effects of ambient sulfur oxides and suspended particles on respiratory health of preadolescent children

    SciTech Connect (OSTI)

    Ware, J.H.; Ferris, B.G. Jr.; Dockery, D.W.; Spengler, J.D.; Stram, D.O.; Speizer, F.E.

    1986-05-01

    Reported here are the results from an ongoing study of outdoor air pollution and respiratory health of children living in six cities in the eastern and midwestern United States. The study enrolled 10,106 white preadolescent children between 1974 and 1977 in 3 successive annual visits to each city. Each child received a spirometric examination, and a parent completed a standard questionnaire. Of this cohort, 8,380 children were seen for a second examination 1 yr later. An air pollution monitoring program was begun in each community at about the time of the first examination. For this report, measurements of total suspended particulates (TSP), the sulfate fraction of TSP (TSO/sub 4/), and sulfur dioxide (SO2) concentrations at study-affiliated outdoor stations were combined with measurements at other public and private monitoring sites to create a record of TSP, TSO/sub 4/, and SO/sub 2/ concentrations in each of 9 air pollution regions during the 1-yr period preceding each examination and, for TSP, during each child's lifetime up to the time of testing. Across the 6 cities, frequency of cough was significantly associated with the average of 24-h mean concentrations of all 3 air pollutants during the year preceding the health examination (p less than 0.01). Rates of bronchitis and a composite measure of lower respiratory illness were significantly associated with average particulate concentrations (p less than 0.05). In analyses restricted to lifetime residents, these outcomes were significantly associated with measures of lifetime mean TSP concentration. Within the cities, however, temporal and spatial variation in air pollutant concentrations and illness and symptom rates were not positively associated.

  2. Meta-Analyses of the Associations of Respiratory Health Effectswith Dampness and Mold in Homes

    SciTech Connect (OSTI)

    Fisk, William J.; Lei-Gomez, Quanhong; Mendell, Mark J.

    2006-01-01

    The Institute of Medicine (IOM) of the National Academy of Sciences recently completed a critical review of the scientific literature pertaining to the association of indoor dampness and mold contamination with adverse health effects. In this paper, we report the results of quantitative meta-analysis of the studies reviewed in the IOM report. We developed point estimates and confidence intervals (CIs) to summarize the association of several respiratory and asthma-related health outcomes with the presence of dampness and mold in homes. The odds ratios and confidence intervals from the original studies were transformed to the log scale and random effect models were applied to the log odds ratios and their variance. Models were constructed both accounting for the correlation between multiple results within the studies analyzed and ignoring such potential correlation. Central estimates of ORs for the health outcomes ranged from 1.32 to 2.10, with most central estimates between 1.3 and 1.8. Confidence intervals (95%) excluded unity except in two of 28 instances, and in most cases the lower bound of the CI exceeded 1.2. In general, the two meta-analysis methods produced similar estimates for ORs and CIs. Based on the results of the meta-analyses, building dampness and mold are associated with approximately 30% to 80% increases in a variety of respiratory and asthma-related health outcomes. The results of these meta-analyses reinforce the IOM's recommendation that actions be taken to prevent and reduce building dampness problems.

  3. Improving the Quality of EEG Data in Patients with Alzheimers Disease Using ICA

    E-Print Network [OSTI]

    Cichocki, Andrzej

    , electromyographic, elec- trodermal, electrovascular, and respiratory signals) may interfere with the EEG in the form

  4. Common Rose Diseases 

    E-Print Network [OSTI]

    Johnk, Janell

    2000-01-11

    is implied. 1. Plant roses in full sun.2. Use drip irrigation or soaker hoses. 3. Water in early morning.4. Selectively prune to open canopy and increase aircirculation. 5. Manage weeds and insects to prevent the spread of viruses. F i ve S te p..., making it moresusceptible to insect problems andother diseases.Management?Prune damaged orinfected canes . The black spot fungusover winters oncanes. Carefulpruning removesdamaged or infectedcanes and slowsdisease development. B lack Spot Rose varieties...

  5. Peanut Diseases Atlas. 

    E-Print Network [OSTI]

    Horne, Wendell C.

    1974-01-01

    Acknowledgments This publication was made possible by a grant from the Texas Peanut Producers Board to the Texas Agricultural Extension Service. This educational support in the area of peanut disease control is appreciated. The author also expresses... appreciation to producers who contributed through the voluntary check-off program and to those Extension staff members and research plant pathologists and nematologists who gave assistance and counsel during the prepara tion of this publication . Peanut...

  6. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  7. Vannida Ket Disease Case Presentation

    E-Print Network [OSTI]

    Brutlag, Doug

    -Sachs disease is classically diagnosed by an eye examination or behavior observation. Ganglion cells in the eye

  8. PLANT DISEASES IN SOUTH CAROLINA

    E-Print Network [OSTI]

    Stuart, Steven J.

    INDEX OF PLANT DISEASES IN SOUTH CAROLINA James H. Blake, Ed.D. Director, Home & Garden Information to compile a list of plant diseases occurring on cultivated and native plants in South Carolina. The data or conclusive list of the diseases of plants in South Carolina. New plants as well as new plant pathogens

  9. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01

    ............................................ Botlv Defense Against Disease 6 Manifestations of Disease ...................................................... 7 ........ Hatcherv and Breeder Flock Health Management 7 Hatchcrv Management and Sanitation ......... .... ........... 8 Principles... ......................................................... 10 Vaccination No Substitute for Sanitation .................... .. 11 Diseases for 'lIrhich Vaccines Are Available .................... 11 ....................... .................. Acl~ninistration of Vaccines ......... 11 -4 Suggested...

  10. The respiratory health and lung function of Anglo-American children in a smelter town

    SciTech Connect (OSTI)

    Dodge, R.

    1983-02-01

    Cooper smelters are large, usually isolated, sources of air pollution. Arizona has several such plants on the periphery of small communities. The smelters emit predominantly sulfur oxides and particulates, and the residents of these communities intermittently are exposed to high concentrations (24-h sulfur dioxide (SO2) . 250 to 500 micrograms/m3) of smelter smoke but little other pollution. This study compared the respiratory health of Anglo-American school children who lived in one smelter community with children living in another small community in Arizona that was free of smelter air pollution. The prevalence of cough, as determined by questionnaire, was 25.6% in the smelter town children and 14.3% in the nonsmelter town children (p less than 0.05). Pulmonary function at the study onset was equal in the two groups. Over the course of the 4 yr of study, lung function growth (measured as actual forced expiratory volume in one second (FEV1) after 4 yr of study minus predicted FEV1) was also equal in the smelter town and nonsmelter town children. These results suggest that children in smelter communities have slightly more cough when compared with children living in other communities, but no differences in initial lung function or lung function at yearly testing over the period of the study.

  11. Daily diaries of respiratory symptoms and air pollution: Methodological issues and results

    SciTech Connect (OSTI)

    Schwartz, J. ); Wypij, D.; Dockery D.; Ware, J.; Spengler, J.; Ferris, B. Jr. ); Zeger, S. )

    1991-01-01

    Daily diaries of respiratory symptoms are a powerful technique for detecting acute effects of air pollution exposure. While conceptually simple, these diary studies can be difficult to analyze. The daily symptom rates are highly correlated, even after adjustment for covariates, and this lack of independence must be considered in the analysis. Possible approaches include the use of incidence instead of prevalence rates and autoregressive models. Heterogeneity among subjects also induces dependencies in the data. These can be addressed by stratification and by two-stage models such as those developed by Korn and Whittemore. These approaches have been applied to two data sets: a cohort of school children participating in the Harvard Six Cities Study and a cohort of student nurses in Los Angeles. Both data sets provide evidence of autocorrelation and heterogeneity. Controlling for autocorrelation corrects the precision estimates, and because diary data are usually positively autocorrelated, this leads to larger variance estimates. Controlling for heterogeneity among subjects appears to increase the effect sizes for air pollution exposure. Preliminary results indicate associations between sulfur dioxide and cough incidence in children and between nitrogen dioxide and phlegm incidence in student nurses.

  12. Relationship of respiratory symptoms and pulmonary function to tar, nicotine, and carbon monoxide yield of cigarettes

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Sherrill, D.L.; Paoletti, P.; Lebowitz, M.D. )

    1991-02-01

    The data from consecutive surveys of the Tucson Epidemiologic Study (1981-1988) were used to evaluate the relationship in cigarette smokers of respiratory symptoms and pulmonary function to tar, nicotine, and carbon monoxide (CO) yields of the cigarette. There were 690 subjects who reported smoking regularly in at least one survey, over age 15. After adjustment for intensity and duration of smoking and for depth of inhalation, the risk of chronic phlegm, cough, and dyspnea were not related to the tar and nicotine yields. In 414 subjects with pulmonary function tested in at least one of the three surveys the spirometric indices used were significantly related to the daily dose of tar, nicotine, and CO (product of the cigarette yield and daily number of cigarettes smoked). The effects were more pronounced for past than for current doses. However, the differentiation of pulmonary function due to various yields of cigarettes was small in comparison to the difference in pulmonary function between smokers and nonsmokers.

  13. Spirometry variability criteria--association with respiratory morbidity and mortality in a cohort of coal miners

    SciTech Connect (OSTI)

    Kellie, S.E.; Attfield, M.D.; Hankinson, J.L.; Castellan, R.M.

    1987-03-01

    To clarify the association between spirometry variability and respiratory morbidity and mortality, the authors analyzed data for miners examined in the first round of the National Coal Study, 1969-1971, and they compared groups of miners who failed with those who met each of two spirometry variability criteria: a 5% criterion recommended by the American Thoracic Society, and a 200 ml criterion used in prior research studies. Compared with miners who met the 5% criterion (the best two forced vital capacities must be within 5% or 100 ml of one another), the group that failed had a lower mean for forced expiratory volume in one second (FEV1), and odds ratios for cough, phlegm, wheeze, shortness of breath, and death of 1.75, 1.67, 1.76, 2.71, and 1.30, respectively. The findings for the 200 ml criterion (the best two FEV1s must be within 200 ml of one another) were somewhat different. The group that failed versus the group that met this criterion had a higher mean for FEV1, and odds ratios for cough, phlegm, wheeze, shortness of breath, and death of 1.13, 1.07, 1.15, 1.43, and 0.94, respectively. Although the findings differ for the two criteria, the findings demonstrate that increased spirometry variability is associated with poorer health.

  14. Epidemiological-environmental study of diesel bus garage workers: chronic effects of diesel exhaust on the respiratory system

    SciTech Connect (OSTI)

    Gamble, J.; Jones, W.; Minshall, S.

    1987-10-01

    Two hundred and eighty-three (283) male diesel bus garage workers from four garages in two cities were examined to determine if there was excess chronic respiratory morbidity related to diesel exposure. The dependent variables were respiratory symptoms, radiographic interpretation for pneumoconiosis, and pulmonary function (FVC, FEV1, and flow rates). Independent variables included race, age, smoking, drinking, height, and tenure (as surrogate measure of exposure). Exposure-effect relationships within the study population showed no detectable associations of symptoms with tenure. There was an apparent association of pulmonary function and tenure. Seven workers (2.5%) had category 1 pneumoconiosis (three rounded opacities, two irregular opacities, and one with both rounded and irregular). The study population was also compared to a nonexposed blue-collar population. After indirect adjustment for age, race, and smoking, the study population had elevated prevalences of cough, phlegm, and wheezing, but there was no association with tenure. Dyspnea showed a dose-response trend but no apparent increase in prevalence. Mean percent predicted pulmonary function of the study population was greater than 100%, i.e., elevated above the comparison population. These data show there is an apparent effect of diesel exhaust on pulmonary function but not chest radiographs. Respiratory symptoms are high compared to blue-collar workers, but there is no relationship with tenure.

  15. Management of Respiratory Motion in Extracorporeal High-Intensity Focused Ultrasound Treatment in Upper Abdominal Organs: Current Status and Perspectives

    SciTech Connect (OSTI)

    Muller, A., E-mail: arnaud.muller@chu-lyon.fr [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France); Petrusca, L.; Auboiroux, V. [University of Geneva, Department of Radiology, Faculty of Medicine (Switzerland)] [University of Geneva, Department of Radiology, Faculty of Medicine (Switzerland); Valette, P. J. [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France)] [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France); Salomir, R. [University of Geneva, Department of Radiology, Faculty of Medicine (Switzerland)] [University of Geneva, Department of Radiology, Faculty of Medicine (Switzerland); Cotton, F. [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France)] [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France)

    2013-12-15

    Extracorporeal high-intensity focused ultrasound (HIFU) is a minimally invasive therapy considered with increased interest for the ablation of small tumors in deeply located organs while sparing surrounding critical tissues. A multitude of preclinical and clinical studies have showed the feasibility of the method; however, concurrently they showed several obstacles, among which the management of respiratory motion of abdominal organs is at the forefront. The aim of this review is to describe the different methods that have been proposed for managing respiratory motion and to identify their advantages and weaknesses. First, we specify the characteristics of respiratory motion for the liver, kidneys, and pancreas and the problems it causes during HIFU planning, treatment, and monitoring. Second, we make an inventory of the preclinical and clinical approaches used to overcome the problem of organ motion. Third, we analyze their respective benefits and drawbacks to identify the remaining physical, technological, and clinical challenges. We thereby consider the outlook of motion compensation techniques and those that would be the most suitable for clinical use, particularly under magnetic resonance thermometry monitoring.

  16. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  17. A computational study of the respiratory airflow characteristics in normal and obstructed human airways

    E-Print Network [OSTI]

    and Advanced Technology Research Center, United States Army Medical Research and Materiel Command, Fort Detrick for high expiratory flow rates (42300 ml/s), but not for inspiratory flow rates. Moreover, airflow patterns and diseased conditions. Further, we showed that wall shear stresses were not only dependent on breathing rates

  18. Similarities of host defense mechanisms against pulmonary infectious disease in animals and man

    SciTech Connect (OSTI)

    Green, G.M.

    1984-01-01

    Evidence linking exposure to air pollutants with increased susceptibility to infectious diseases in humans comes from epidemiological, clinical, and experimental laboratory studies. The data suggest that the most common, and perhaps the most sensitive, index of the pulmonary effect of air pollutant exposure is on post upper respiratory infection, prolonged cough, phlegm, and purulent sputum. Experimental models of these relationships for extrapolation to humans should be able to measure such minor changes in symptomatology and physiology rather than require major lethal events. The bacterial aerosol model for quantifying nonspecific defense mechanisms of the bronchopulmonary tree utilizing nonpathogenic organisms fulfills this criterion. The function of the six major components of pulmonary antimicrobial defense mechanisms - including aerodynamic filtration, secretory respiratory tract fluid, fluid transport at the alveolar and bronchial levels, the phagocytic function of alveolar macrophages, the augmenting mechanisms of blood-derived inflammatory cells, and the secretory and cellular-specific immune mechanisms and their mediator products - can all be quantified by this experimental animal model system. The defensive functions are remarkably similar across animal species, and available human data suggest that findings obtained using the model may be extrapolatred to humans.

  19. The etiology of loin disease 

    E-Print Network [OSTI]

    Greeley, Ralph Gordon

    1966-01-01

    treatment has been discovered and the etiology of the disease has never been proven. In South Africa a similar disease, larnsiekte, has been recorded for centuries. In the 1920's intensive research in that country un- covered a chain of conditions... the similarity of lamsiekte and loin disease, and of the phosphorus deficiency that soils of South Africa and the Texas coastal plains have in common. In 1924 he began recommending the routine supplemental feeding of phos- phorus to range cattle (8). Where...

  20. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular Biologist, of the Mathematical and Computational Epidemiology Team at Los Alamos National Laboratory Science Friday Interviews Mining Wikipedia Data to Track Disease...

  1. SU-E-J-63: Estimating the Effects of Respiratory Motion On Dose Heterogeneity for ITV-Based Treatments

    SciTech Connect (OSTI)

    Williams, C; Lewis, J

    2014-06-01

    Purpose: To quantify the relationship between the amount of dose heterogeneity in a treatment plan that uses an internal target volume (ITV) to account for respiratory motion and the true amount of heterogeneity in the dose delivered to the tumor contained within that ITV. Methods: We develop a convolution-based framework for calculating dose delivered to a tumor moving inside an ITV according to a common sinusoid-based breathing model including asymmetry. We model the planned ITV dose distribution as a centrally peaked analytic function approximating the profile of clinical stereotactic body radiotherapy treatments. Expressions for the minimum and maximum dose received by the tumor are derived and evaluated for a range of clinically relevant parameters. Results of the model are validated with phantom measurements using an ion chamber array. Results: An analytic expression is presented for the maximum and minimum doses received by the tumor relative to the planned ITV dose. The tumor dose heterogeneity depends solely on the ratio of tumor size to ITV size, the peak dose in the planned ITV dose distribution, and the respiratory asymmetry parameter. Under the assumptions of this model, using a typical breathing asymmetry parameter and a dose distribution with a fixed size ITV covered by the 100% line and with a 130% hotspot, the maximum dose to the tumor varies between 113%–130%, and the minimum dose varies between 100%–116% depending on the amount of tumor motion. Conclusion: This modeling exercise demonstrates the interplay between motion and dose heterogeneity. Tumors that exhibit large amounts of respiratory motion relative to their size will receive a more homogeneous dose and a larger minimum dose than would be inferred from the ITV dose distribution. This effect is not captured in current clinical treatment planning methods unless 4D dose calculation techniques are used. This work was partially supported by a Varian Medical Systems research grant.

  2. Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat

    SciTech Connect (OSTI)

    Kimbell, J.S.; Gross, E.A.; Joyner, D.R.; Godo, M.N.; Morgan, K.T. (Chemical Industry Institute of Toxicology, Research Triangle Park, NC (United States))

    1993-08-01

    For certain inhaled air pollutants, such as reactive, water soluble gases, the distribution of nasal lesions observed in F344 rats may be closely related to regional gas uptake patterns in the nose. These uptake patterns can be influenced by the currents of air flowing through the upper respiratory tract during the breathing cycle. Since data on respiratory tract lesions in F344 rats are extrapolated to humans to make predictions of risk to human health, a better understanding of the factors affecting these responses is needed. To assess potential effects of nasal airflow on lesion location and severity, a methodology was developed for creation of computer simulations of steady-state airflow and gas transport using a three-dimensional finite element grid reconstructed from serial step-sections of the nasal passages of a male F344 rat. Simulations on a supercomputer used the computational fluid dynamics package FIDAP (FDI, Evanston, IL). Distinct streams of bulk flow evident in the simulations matched inspiratory streams reported for the F344 rat. Moreover, simulated regional flow velocities matched measured velocities in concurrent laboratory experiments with a hollow nasal mold. Computer-predicted flows were used in simulations of gas transport to nasal passage walls, with formaldehyde as a test case. Results from the uptake simulations were compared with the reported distribution of formaldehyde-induced nasal lesions observed in the F344 rat, and indicated that airflow-driven uptake patterns probably play an important role in determining the location of certain nasal lesions induced by formaldehyde. This work demonstrated the feasibility of applying computational fluid dynamics to airflow-driven dosimetry of inhaled chemicals in the upper respiratory tract.

  3. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches disease is more complex than increased exposure to pollution and allergens and that early childhood of outdoor factors to allergic disease. Influence of Exposure to Pollutants on the Manifestation of Allergic

  4. Publications Fish Disease Diagnosis and

    E-Print Network [OSTI]

    Publications Fish Disease Diagnosis and Basic Fishery Computer Programs The second edition of "Disease Diagnosis and Control in North American Marine Aquaculture," edited by Carl J. Sindermann edition should be a big help to aquaculturists and others involved in the detection, prevention

  5. Occupational Disease in Connecticut, 2014

    E-Print Network [OSTI]

    Oliver, Douglas L.

    Occupational Disease in Connecticut, 2014 This report covers data for 2012 and was prepared under contract for the State of Connecticut Workers' Compensation Commission, John A. Mastropietro, Chairman, as part of the Occupational Disease Surveillance Program, operated in cooperation with the Connecticut

  6. COMPARATIVE COMPUTATIONAL MODELING OF AIRFLOWS AND VAPOR DOSIMETY IN THE RESPIRATORY TRACTS OF RAT, MONKEY, AND HUMAN

    SciTech Connect (OSTI)

    Corley, Richard A.; Kabilan, Senthil; Kuprat, Andrew P.; Carson, James P.; Minard, Kevin R.; Jacob, Rick E.; Timchalk, Charles; Glenny, Robb W.; Pipavath, Sudhaker; Cox, Timothy C.; Wallis, Chris; Larson, Richard; Fanucchi, M.; Postlewait, Ed; Einstein, Daniel R.

    2012-07-01

    Coupling computational fluid dynamics (CFD) with physiologically based pharmacokinetic (PBPK) models is useful for predicting site-specific dosimetry of airborne materials in the respiratory tract and elucidating the importance of species differences in anatomy, physiology, and breathing patterns. Historically, these models were limited to discrete regions of the respiratory system. CFD/PBPK models have now been developed for the rat, monkey, and human that encompass airways from the nose or mouth to the lung. A PBPK model previously developed to describe acrolein uptake in nasal tissues was adapted to the extended airway models as an example application. Model parameters for each anatomic region were obtained from the literature, measured directly, or estimated from published data. Airflow and site-specific acrolein uptake patterns were determined under steadystate inhalation conditions to provide direct comparisons with prior data and nasalonly simulations. Results confirmed that regional uptake was dependent upon airflow rates and acrolein concentrations with nasal extraction efficiencies predicted to be greatest in the rat, followed by the monkey, then the human. For human oral-breathing simulations, acrolein uptake rates in oropharyngeal and laryngeal tissues were comparable to nasal tissues following nasal breathing under the same exposure conditions. For both breathing modes, higher uptake rates were predicted for lower tracheo-bronchial tissues of humans than either the rat or monkey. These extended airway models provide a unique foundation for comparing dosimetry across a significantly more extensive range of conducting airways in the rat, monkey, and human than prior CFD models.

  7. Insights into the respiratory tract microbiota of patients with cystic fibrosis during early Pseudomonas aeruginosa colonization

    SciTech Connect (OSTI)

    Keravec, Marlène; Mounier, Jérôme; Prestat, Emmanuel; Vallet, Sophie; Jansson, Janet K.; Burgaud, Gaëtan; Rosec, Sylvain; Gouriou, Stéphanie; Rault, Gilles; Coton, Emmanuel; Barbier, Georges; Héry-Arnaud, Geneviève

    2015-08-09

    Pseudomonas aeruginosa plays a major role in cystic fibrosis (CF) progression. Therefore, it is important to understand the initial steps of P. aeruginosa infection. The structure and dynamics of CF respiratory tract microbial communities during the early stages of P. aeruginosa colonization were characterized by pyrosequencing and cloning-sequencing. The respiratory microbiota showed high diversity, related to the young age of the CF cohort (mean age 10 years). Wide inter- and intra-individual variations were revealed. A common core microbiota of 5 phyla and 13 predominant genera was found, the majority of which were obligate anaerobes. A few genera were significantly more prevalent in patients never infected by P. aeruginosa. Persistence of an anaerobic core microbiota regardless of P. aeruginosa status suggests a major role of certain anaerobes in the pathophysiology of lung infections in CF. Some genera may be potential biomarkers of pulmonary infection state.

  8. Innovative characteristics of the new dosimetric model for the human respiratory tract studied by the ICRP appointed Task Group of Committee 2

    E-Print Network [OSTI]

    Melandri, C; Tarroni, G

    1991-01-01

    In 1984, the ICRP appointed a Task Group of Committee 2 to review and revise, as necessary, the current lung dosimetric model. On the basis of the knowledge acquired during the past 20 years, the Task Group's approach has been to review, in depth, the morphology and physiology of the human respiratory tract, inspirability of aerosols and regional deposition of inhaled particles as functions of aerosol size and breathing parameters, clearance of deposited materials, nature and specific sites of damage to the respiratory system caused by inhaled radioactive substances. In the proposed model, clearance from the three regions of the respiratory tract (extrathoracic ET, fast-clearing thoracic T sub f and slow-clearing thoracic T sub s , comprising lymph nodes) is described in terms of competition between the mechanical processes moving particles, which do not depend on the substances, and those of absorption into the blood, determined solely by the material. A Task Group report will also include models for calcula...

  9. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  10. Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease

    E-Print Network [OSTI]

    Watts, Amber; Crimmins, Eileen M.; Gatz, Margaret

    2008-09-10

    Periodontal disease (PDD) is associated with increased risk of cardiovascular disease, cerebrovascular disease, and mortality in many studies, while other studies have begun to suggest an association of PDD with Alzheimer’s disease (AD). This paper...

  11. Alzheimer's Disease and Vitamin E

    E-Print Network [OSTI]

    Empey, Matthew

    1998-01-01

    Adelman A. Selegiline and vitamin E in Alzheimer's disease.bomb. Geriatrics Traber MG. Vitamin E in humans: Demand andJ, Cole GM, Schubert D. Vitamin E protects nerve cells from

  12. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01

    ........................................................ 7 Flock Health Management 7 Hatchery Management and Sanitation ............................ 8 Principles of Reasonable Drug Administration ................. .... 9 Drug Administration... Vaccines Are ................................................................... 10 Dangers of Vaccination ........................................................... 10 Vaccination-No Substitute for Sanitation ..... .................... 11 Diseases...

  13. Prudent behaviour accelerates disease transmission

    E-Print Network [OSTI]

    Scarpino, Samuel V; Hebert-Dufresne, Laurent

    2015-01-01

    Infectious diseases often spread faster near their peak than would be predicted given early data on transmission. Despite the commonality of this phenomena, there are no known general mechanisms able to cause an exponentially spreading dis- ease to begin spreading faster. Indeed most features of real world social networks, e.g. clustering1,2 and community structure3, and of human behaviour, e.g. social distancing4 and increased hygiene5, will slow disease spread. Here, we consider a model where individuals with essential societal roles-e.g. teachers, first responders, health-care workers, etc.- who fall ill are replaced with healthy individuals. We refer to this process as relational exchange. Relational exchange is also a behavioural process, but one whose effect on disease transmission is less obvious. By incorporating this behaviour into a dynamic network model, we demonstrate that replacing individuals can accelerate disease transmission. Furthermore, we find that the effects of this process are trivial w...

  14. Diarrheal Disease in Show Swine 

    E-Print Network [OSTI]

    Lawhorn, D. Bruce

    2007-02-27

    from the feces of recovered car- rier pigs or from contaminated premises, trailers or scales. Pigs affected with this disease usually become very sick. This organism infects the cells lining the cecum and spiral colon (the same area as whipworms... disease in show pigs. Infection occurs after pigs ingest microscopic whipworm eggs while rooting or eating in a contaminat- ed environment. Whipworm eggs remain viable for as long as 6 years so contaminated premises are an impor- tant source of infection...

  15. Controlling Diseases on Ornamental Plants. 

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01

    on elms and other shade trees. Mushroom-type fu ngal growths appear on trunk, limbs or roots near the soil surface. Rots may be present for several years before mushrooms ap pear. Tree becomes sus ceptible to wi nd damage. Plants may die back..., irises, lilies, narcissus and tulips. ROOT DISEASES Disease Cotton root rot (fungi) Crown gall Mushroom root rot Symptoms Small flowering plants die within a few days. Shrubs and trees die more slowly. Large trees may die within several...

  16. Inhalation exposure to sulfur mustard in the guinea pig model: Clinical, biochemical and histopathological characterization of respiratory injuries

    SciTech Connect (OSTI)

    Allon, Nahum, E-mail: nahuma@iibr.gov.i [Department of Pharmacology, Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona 74100 (Israel); Amir, Adina; Manisterski, Eliau; Rabinovitz, Ishay; Dachir, Shlomit; Kadar, Tamar [Department of Pharmacology, Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona 74100 (Israel)

    2009-12-01

    Guinea pigs (GP) were exposed (head only) in individual plethysmographs to various concentrations of sulfur mustard vapor, determined online, using FTIR attached to flow chamber. The LCt{sub 50} and the inhaled LD{sub 50} were calculated at different time points post exposure. Surviving animals were monitored for clinical symptoms, respiratory parameters and body weight changes for up to 30 days. Clinical symptoms were noted at 3 h post exposure, characterized by erythematic and swelling nose with extensive mucous secretion (with or without bleeding). At 6 h post exposure most of the guinea pigs had breathing difficulties, rhonchi and dyspnea and few deaths were noted. These symptoms peaked at 48 h and were noted up to 8 days, associated with few additional deaths. Thereafter, a spontaneous healing was noted, characterized by recovery of respiratory parameters and normal weight gain with almost complete apparent healing within 2 weeks. Histopathological evaluation of lungs and trachea in the surviving GPs at 4 weeks post exposure revealed a dose-dependent residual injury in both lung and trachea expressed by abnormal recovery of the tracheal epithelium concomitant with a dose-dependent increase in cellular volume in the lungs. These abnormal epithelial regeneration and lung remodeling were accompanied with significant changes in protein, LDH, differential cell count and glutathione levels in the bronchoalveolar lavage (BAL). It is suggested that the abnormal epithelial growth and cellular infiltration into the lung as well as the continuous lung inflammation could cause recurrent lung injury similar to that reported for HD exposed human casualties.

  17. SU-E-J-73: Generation of Volumetric Images with a Respiratory Motion Model Based On An External Surrogate Signal

    SciTech Connect (OSTI)

    Hurwitz, M; Williams, C; Mishra, P; Dhou, S; Lewis, J

    2014-06-01

    Purpose: Respiratory motion during radiotherapy treatment can differ significantly from motion observed during imaging for treatment planning. Our goal is to use an initial 4DCT scan and the trace of an external surrogate marker to generate 3D images of patient anatomy during treatment. Methods: Deformable image registration is performed on images from an initial 4DCT scan. The deformation vectors are used to develop a patient-specific linear relationship between the motion of each voxel and the trajectory of an external surrogate signal. Correlations in motion are taken into account with principal component analysis, reducing the number of free parameters. This model is tested with digital phantoms reproducing the breathing patterns of ten measured patient tumor trajectories, using five seconds of data to develop the model and the subsequent thirty seconds to test its predictions. The model is also tested with a breathing physical anthropomorphic phantom programmed to reproduce a patient breathing pattern. Results: The error (mean absolute, 95th percentile) over 30 seconds in the predicted tumor centroid position ranged from (0.8, 1.3) mm to (2.2, 4.3) mm for the ten patient breathing patterns. The model reproduced changes in both phase and amplitude of the breathing pattern. Agreement between prediction and truth over the entire image was confirmed by assessing the global voxel intensity RMS error. In the physical phantom, the error in the tumor centroid position was less than 1 mm for all images. Conclusion: We are able to reconstruct 3D images of patient anatomy with a model correlating internal respiratory motion with motion of an external surrogate marker, reproducing the expected tumor centroid position with an average accuracy of 1.4 mm. The images generated by this model could be used to improve dose calculations for treatment planning and delivered dose estimates. This work was partially funded by a research grant from Varian Medical Systems.

  18. SU-E-T-452: Impact of Respiratory Motion On Robustly-Optimized Intensity-Modulated Proton Therapy to Treat Lung Cancers

    SciTech Connect (OSTI)

    Liu, W; Schild, S; Bues, M [Mayo Clinic Arizona, Phoenix, AZ (United States); Liao, Z; Sahoo, N [MD Anderson Cancer Center, Houston, TX (United States); Park, P [Scottsdale, GA (United States); Li, H [M.D. Anderson Cancer Center, Houston, TX (United States); Li, Y [Varian Medical Systems, Houston, TX (United States); Li, X; Shen, J [Mayo Clinic Arizona, Phoenix, AA (United States); Anand, A [Mayo Clinic Arizona, Phoenix (United States); Dong, L [Scripps Proton Therapy Center, San Diego, CA (United States); Zhu, X; Mohan, R [UT MD Anderson Cancer Center, Houston, TX (United States)

    2014-06-01

    Purpose: We compared conventionally optimized intensity-modulated proton therapy (IMPT) treatment plans against the worst-case robustly optimized treatment plans for lung cancer. The comparison of the two IMPT optimization strategies focused on the resulting plans' ability to retain dose objectives under the influence of patient set-up, inherent proton range uncertainty, and dose perturbation caused by respiratory motion. Methods: For each of the 9 lung cancer cases two treatment plans were created accounting for treatment uncertainties in two different ways: the first used the conventional Method: delivery of prescribed dose to the planning target volume (PTV) that is geometrically expanded from the internal target volume (ITV). The second employed the worst-case robust optimization scheme that addressed set-up and range uncertainties through beamlet optimization. The plan optimality and plan robustness were calculated and compared. Furthermore, the effects on dose distributions of the changes in patient anatomy due to respiratory motion was investigated for both strategies by comparing the corresponding plan evaluation metrics at the end-inspiration and end-expiration phase and absolute differences between these phases. The mean plan evaluation metrics of the two groups were compared using two-sided paired t-tests. Results: Without respiratory motion considered, we affirmed that worst-case robust optimization is superior to PTV-based conventional optimization in terms of plan robustness and optimality. With respiratory motion considered, robust optimization still leads to more robust dose distributions to respiratory motion for targets and comparable or even better plan optimality [D95% ITV: 96.6% versus 96.1% (p=0.26), D5% - D95% ITV: 10.0% versus 12.3% (p=0.082), D1% spinal cord: 31.8% versus 36.5% (p =0.035)]. Conclusion: Worst-case robust optimization led to superior solutions for lung IMPT. Despite of the fact that robust optimization did not explicitly account for respiratory motion it produced motion-resistant treatment plans. However, further research is needed to incorporate respiratory motion into IMPT robust optimization.

  19. the heart truth What is heart Disease?

    E-Print Network [OSTI]

    Shen, Jun

    the heart truth® for Women What is heart Disease? Coronary heart disease (CHD) is the most common form of heart disease. Usually referred to simply as "heart disease," it is a disorder of the blood vessels of the heart in which a waxy substance called plaque builds up in the coronary (heart) arteries

  20. 200 Plant Disease / Vol. 87 No. 2200 Disease Notes

    E-Print Network [OSTI]

    Pappu, Hanu R.

    Leaf Curl Begomoviruses from Pakistan. S. L. Shih, W. S. Tsai, and S. K. Green, The Asian Vegetable Disease Research Institute, National Agricultural Research Centre, Islamabad, Pakistan; M. A. Rezaian in Pakistan. One chili sample with leaf curl symptoms was collected in 1998 in Multan (Punjab Province

  1. MAR 384 -DISEASES OF AQUATIC ORGANISMS (3 credits)

    E-Print Network [OSTI]

    Allam, Bassem

    . Disease management 26. Advances in aquatic animal disease Part I (vaccination, probiotics) 27. Advances

  2. Patching genes to fight disease

    SciTech Connect (OSTI)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  3. Disease Management in Organic Plantings

    E-Print Network [OSTI]

    Isaacs, Rufus

    cooling or proper drying · Clean harvesting and processing equipment · Control insects that may createGard (Gliocladium virens) Blight Ban (Pseudomonas fluorescens) PlantShield (Trichoderma harzianum) Agri Antibiotics for control of bacterial diseases #12;Effect of Trichoderma hamatum (T382) in potting mix

  4. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  5. Social Cognition in Frontotemporal Dementia, Motor Neurone Disease, and Alzheimer's Disease 

    E-Print Network [OSTI]

    Oliver, Lindsay

    2011-11-23

    cognition across a number of neurodegenerative diseases, a test battery and two questionnaires were administered to frontal variant frontotemporal dementia (fvFTD), motor neurone disease (MND), Alzheimer`s disease, and healthy control participant groups...

  6. Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?

    SciTech Connect (OSTI)

    Matney, Jason; Park, Peter C. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); The University of Texas Graduate School of Biomedical Sciences, Houston, Texas (United States); Bluett, Jaques [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chen, Yi Pei [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); The University of Texas Graduate School of Biomedical Sciences, Houston, Texas (United States); Liu, Wei; Court, Laurence E. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Li, Heng [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe, E-mail: rmohan@mdanderson.org [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-11-01

    Purpose: To quantify and compare the effects of respiratory motion on paired passively scattered proton therapy (PSPT) and intensity modulated photon therapy (IMRT) plans; and to establish the relationship between the magnitude of tumor motion and the respiratory-induced dose difference for both modalities. Methods and Materials: In a randomized clinical trial comparing PSPT and IMRT, radiation therapy plans have been designed according to common planning protocols. Four-dimensional (4D) dose was computed for PSPT and IMRT plans for a patient cohort with respiratory motion ranging from 3 to 17 mm. Image registration and dose accumulation were performed using grayscale-based deformable image registration algorithms. The dose–volume histogram (DVH) differences (4D-3D [3D = 3-dimensional]) were compared for PSPT and IMRT. Changes in 4D-3D dose were correlated to the magnitude of tumor respiratory motion. Results: The average 4D-3D dose to 95% of the internal target volume was close to zero, with 19 of 20 patients within 1% of prescribed dose for both modalities. The mean 4D-3D between the 2 modalities was not statistically significant (P<.05) for all dose–volume histogram indices (mean ± SD) except the lung V5 (PSPT: +1.1% ± 0.9%; IMRT: +0.4% ± 1.2%) and maximum cord dose (PSPT: +1.5 ± 2.9 Gy; IMRT: 0.0 ± 0.2 Gy). Changes in 4D-3D dose were correlated to tumor motion for only 2 indices: dose to 95% planning target volume, and heterogeneity index. Conclusions: With our current margin formalisms, target coverage was maintained in the presence of respiratory motion up to 17 mm for both PSPT and IMRT. Only 2 of 11 4D-3D indices (lung V5 and spinal cord maximum) were statistically distinguishable between PSPT and IMRT, contrary to the notion that proton therapy will be more susceptible to respiratory motion. Because of the lack of strong correlations with 4D-3D dose differences in PSPT and IMRT, the extent of tumor motion was not an adequate predictor of potential dosimetric error caused by breathing motion.

  7. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  8. Best Management Practices for Equine Disease Prevention 

    E-Print Network [OSTI]

    Scott, Brett D.

    2008-10-06

    AnimalDiseases,Revised1998] SchoolofVeterinaryMedicine,UniversityofWisconsin- Madison. Zoonotic Diseases Tutorial. www.vetmed.wisc.edu/pbs/zoonoses Hammer,Carolyn,2005, Equine Biological Risk Management.IowaStateUniversity. www.cfsph.iastate.edu Griffin...

  9. Karnal Bunt: A Disease of Wheat 

    E-Print Network [OSTI]

    Schuster, Greta; Krausz, Joseph P.; Rush, Charlie

    2002-11-20

    Karnal bunt is a fungal disease that affects wheat, durum wheat and triticale. This publication explains the life cycle of the disease, how it spreads, and methods of control....

  10. Does Drinking Tea Protect Against Cardiovascular Disease?

    E-Print Network [OSTI]

    Thompson, Natasha

    2003-01-01

    Maclure M, Muller JE et al. Tea consumption and mortalityU, Poole C, Arab L. Does Tea Affect Cardiovascular Disease?al. Regular Ingestion of black tea improves brachial artery

  11. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  12. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  13. SAGE-Hindawi Access to Research Advances in Orthopedics

    E-Print Network [OSTI]

    Azad, Abdul-Majeed

    with TiO2 nanocrystals or nanotubes as means of effective disinfectants for the prevention of major structure of photoactive TiO2 on the surface of Ti plates and wires is described. The nanoscale TiO2 films at least 50% reduction in the population of E. coli colonies (concentration 2.15 × 107 cells/mL) on TiO2

  14. A Community-Based Approach to Developing a Mobile Device for Measuring Ambient Air Exposure, Location, and Respiratory Health

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Rohlman, Diana; Syron, Laura; Hobbie, Kevin; Anderson, Kim A.; Scaffidi, Christopher; Sudakin, Daniel; Peterson, Elena S.; Waters, Katrina M.; Haynes, Erin; Arkin, Lisa; et al

    2015-08-15

    In west Eugene (Oregon), community research indicates residents are disproportionately exposed to industrial air pollution and exhibit increased asthma incidence. In Carroll County (Ohio), recent increases in unconventional natural gas drilling sparked air quality concerns. These community concerns led to the development of a prototype mobile device to measure personal chemical exposure, location, and respiratory function. Working directly with the environmental justice (EJ) communities, the prototype was developed to (1) meet the needs of the community and; (2) evaluate the use in EJ communities. The prototype was evaluated in 3 community focus groups (n=25) to obtain feedback on the prototypemore »and feasibility study design to evaluate the efficacy of the device to address community concerns. Focus groups were recorded and qualitatively analyzed with discrete feedback tabulated for further refinement. The prototype was improved by community feedback resulting in 8 alterations/additions to software and instructional materials. Overall, focus group participants were supportive of the device and believed it would be a useful environmental health tool. The use of focus groups ensured that community members were engaged in the research design and development of a novel environmental health tool. We found that community-based research strategies resulted in a refined device as well as relevant research questions, specific to the EJ community needs and concerns.« less

  15. SU-E-T-66: Characterization of Radiation Dose Associated with Dark Currents During Beam Hold for Respiratory-Gated Electron Therapy

    SciTech Connect (OSTI)

    Hessler, J; Gupta, N; Rong, Y; Weldon, M

    2014-06-01

    Purpose: The main objective of this study was to estimate the radiation dose contributed by dark currents associated with the respiratory-gated electron therapy during beam hold. The secondary aim was to determine clinical benefits of using respiratory-gated electron therapy for left-sided breast cancer patients with positive internal mammary nodes (IMN). Methods: Measurements of the dark current-induced dose in all electron modes were performed on multiple Siemens and Varian linear accelerators by manually simulating beam-hold during respiratory gating. Dose was quantified at the machine isocenter by comparing the collected charge to the known output for all energies ranging from 6 to 18 MeV for a 10cm × 10cm field at 100 SSD with appropriate solid-water buildup. Using the Eclipse treatment planning system, we compared the additional dose associated with dark current using gated electron fields to the dose uncertainties associated with matching gated photon fields and ungated electron fields. Dose uncertainties were seen as hot and cold spots along the match line of the fields. Results: The magnitude of the dose associated with dark current is highly correlated to the energy of the beam and the amount of time the beam is on hold. For lower energies (6–12 MeV), there was minimal dark current dose (0.1–1.3 cGy/min). Higher energies (15–18 MeV) showed measurable amount of doses. The dark current associated with the electron beam-hold varied between linear accelerator vendors and depended on dark current suppression and the age of the linear accelerator. Conclusion: For energies up to 12 MeV, the dose associated with the dark current for respiratorygated electron therapy was shown to be negligible, and therefore should be considered an option for treating IMN positive left-sided breast cancer patients. However, at higher energies the benefit of respiratory gating may be outweighed by dose due to the dark current.

  16. Biomarker for Lung and Inflammatory Diseases

    E-Print Network [OSTI]

    Heydari, Payam

    Biomarker for Lung and Inflammatory Diseases Tech ID: 23381 / UC Case 2012-660-0 BACKGROUND and clinical research. We describe herein a novel biomarker and method of detecting interstitial lung disease have discovered that patients with interstitial lung and intestinal inflammatory diseases, for example

  17. Linkage Disequilibrium Mapping and Parkinson's Disease

    E-Print Network [OSTI]

    Parkinson's Disease Genetics Study Group, Science 279, 1116 (1998); T. Lynch et al., ibid., 278, 1212 (1997Linkage Disequilibrium Mapping and Parkinson's Disease Several investigators (1) have questioned with Parkinson's disease (PD) in four appar- ently unrelated Italian and Greek families, may be a cause

  18. Akt Isoforms in Vascular Disease

    E-Print Network [OSTI]

    Yu, Haixiang; Littlewood, Trevor; Bennett, Martin

    2015-04-28

    aneurysm; eNOS, endothelial nitric oxide synthase;mTOR,mammalian target of rapamycin. 44 1223 331505. . This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). orms in vascular disease, Vascul. Pharmacol. (2015... p85 subunit and a catalytic p110 subunit that directly phosphorylates the ribosomal protein kinase p70s6k [29], the rho family polypeptide Rac [30], the serum and glucocorticoid-induced kinases SGK [31–33], and the serine/threonine kinase Akt [34...

  19. Diseases of Peaches and Plums. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    the possibility of root injury during cultivation as much as possible. Mushroom Root Rot Mushroom root rot is a fungal disease commonly known as "post oak root rot," "shoestring root rot" or "mushroom root rot." It attacks peach, pear, plum, apple and many... trees. Do not replant trees in old orchard sites infested with mushroom root rot. Cotton Root Rot Peach and plum trees die suddenly after show ing first symptoms of wilting. When roots are pulled from the soil, the bark is decayed, and covered...

  20. The South Karelia Air Pollution Study. The effects of malodorous sulfur compounds from pulp mills on respiratory and other symptoms

    SciTech Connect (OSTI)

    Jaakkola, J.J.; Vilkka, V.; Marttila, O.; Jaeppinen, P.H.; Haahtela, T. )

    1990-12-01

    The paper mills in South Karelia, the southeast part of Finland, are responsible for releasing a substantial amount of malodorous sulfur compounds such as hydrogen sulfide (H2S), methyl mercaptan (CH3SH), and methyl sulfides ((CH3)2S and (CH3)2S2), into ambient air. In the most polluted residential area the annual mean concentrations of hydrogen sulfide and methyl mercaptan are estimated to be 8 and 2 to 5 micrograms/m3 and the highest daily average concentration 100 and 50 micrograms/m3. The annual mean and highest daily concentrations of sulfur dioxide (SO2) are very low. We studied the effects of malodorous sulfur compounds on eye, nasal and respiratory symptoms, and headache in adults. A cross-sectional self-administered questionnaire was distributed in February 1987 and responded to by 488 adults living in a severely (n = 198), a moderately (n = 204), and a nonpolluted community (n = 86). This included questions about occurrence of the symptoms of interest during the previous 4 wk and 12 months and individual, behavioral, and other environmental determinants of the symptoms. The response rate was 83%. The odds ratios (OR) for symptoms experienced often or constantly in severely versus nonpolluted and moderately versus nonpolluted communities were estimated in logistic regression analysis controlling potential confounders. The odds ratios for eye (moderate exposure OR 11.70, Cl95% 2.33 to 58.65; severe exposure OR 11.78, Cl95% 2.35 to 59.09) and nasal symptoms (OR 2.01, Cl95% 0.97 to 4.15; OR 2.19, Cl95% 1.06 to 4.55) and cough (OR 1.89, Cl95% 0.61 to 5.86; OR 3.06, Cl95% 1.02 to 9.29) during the previous 12 months were increased, with a dose-response pattern.

  1. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  2. Major Oak Diseases and Their Control. 

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01

    in many areas where oaks are the predominant native tree species. Research shows that much of this mortality is due to disease-causing organisms or disease complexes 10- volving environmental stress and pathogens. FOLIAR DISEASES Anthracnose (Fungus... tor nado, hurricane, severe hail or following a period of mechanical activity around oak trees. Heavy equip- ment working around trees can create large wounds. When this occurs, insects are attracted to the site and may be carrying the wilt...

  3. Diseases of Small Grains in Texas. 

    E-Print Network [OSTI]

    Atkins, I. M.; Futrell, M. C.

    1958-01-01

    Diseases - of SMALL GRAINS in cooperation with the UNITED STATES DEPARTMENT OF AGRICULTURE TEXAS AGRICULTURAL EXPERIMENT STATION R. D. LEWIS, DIRECTOR. COLLEGE STATIOKJ. TEXAS DIGEST CONTENTS 1 Diseases of small grains are important factors... and international signif- icance. The fall infection, winter survival and spring increase in South Texas of airborne pathogens, such as the cereal rusts, may endanger the small grain crops throughout Texas and other states. Diseases of wheat, which consistently...

  4. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  5. HANFORD THYROID DISEASE STUDY FINAL REPORT

    E-Print Network [OSTI]

    HANFORD THYROID DISEASE STUDY FINAL REPORT Study Management Team Scott Davis, Ph.D., Principal Gilman, Jennifer Sporleder, Jan Kikuchi, Bill Mullin, Liza Noonan, Chuck Wiggins, Belen Gallardo

  6. "Artificial" brains, electrical grids, and disease modeling:...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for...

  7. Sci—Thur AM: YIS - 01: Dosimetric Analysis of Respiratory Induced Cardiac Intrafraction Motion in Left-sided Breast Cancer Radiotherapy

    SciTech Connect (OSTI)

    El-Sherif, O; Xhaferllari, I; Patrick, J; Yu, E; Gaede, S

    2014-08-15

    Introduction: Long-term cardiac side effects in left-sided breast cancer patients (BREL) after post-operative radiotherapy has become one of the most debated issues in radiation oncology. Through breathing-adapted radiotherapy the volume of the heart exposed to radiation can be significantly reduced by delivering the radiation only at the end of inspiration phase of the respiratory cycle, this is referred to as inspiration gating (IG). The purpose of this study is to quantify the potential reduction in cardiac exposure during IG compared to conventional BREL radiotherapy and to assess the dosimetric impact of cardiac motion due to natural breathing. Methods: 24 BREL patients treated with tangential parallel opposed photon beams were included in this study. All patients received a standard fast helical planning CT (FH-CT) and a 4D-CT. Treatment plans were created on the FH-CT using a clinical treatment planning system. The original treatment plan was then superimposed onto the end of inspiration CT and all 10 phases of the 4D-CT to quantify the dosimetric impact of respiratory motion and IG through 4D dose accumulation. Results: Through IG the mean dose to the heart, left ventricle, and left anterior descending artery (LAD) can be reduced in comparison to the clinical standard BREL treatment by as much as 8.39%, 10.11%, and 13.71% respectively (p < 0.05). Conclusion: Failure to account for respiratory motion can lead to under or overestimation in the calculated DVH for the heart, and it's sub-structures. IG can reduce cardiac exposure especially to the LAD during BREL radiotherapy.

  8. SU-E-J-155: Utilizing Varian TrueBeam Developer Mode for the Quantification of Mechanical Limits and the Simulation of 4D Respiratory Motion

    SciTech Connect (OSTI)

    Moseley, D; Dave, M [Princess Margaret Hospital, Toronto, ON (Canada)

    2014-06-01

    Purpose: Use Varian TrueBeam Developer mode to quantify the mechanical limits of the couch and to simulate 4D respiratory motion. Methods: An in-house MATLAB based GUI was created to make the BEAM XML files. The couch was moved in a triangular wave in the S/I direction with varying amplitudes (1mm, 5mm, 10mm, and 50mm) and periods (3s, 6s, and 9s). The periods were determined by specifying the speed. The theoretical positions were compared to the values recorded by the machine at 50 Hz. HD videos were taken for certain tests as external validation. 4D Respiratory motion was simulated by an A/P MV beam being delivered while the couch moved in an elliptical manner. The ellipse had a major axis of 2 cm (S/I) and a minor axis of 1 cm (A/P). Results: The path planned by the TrueBeam deviated from the theoretical triangular form as the speed increased. Deviations were noticed starting at a speed of 3.33 cm/s (50mm amplitude, 6s period). The greatest deviation occurred in the 50mm- 3s sequence with a correlation value of ?0.13 and a 27% time increase; the plan essentially became out of phase. Excluding these two, the plans had correlation values of 0.99. The elliptical sequence effectively simulated a respiratory pattern with a period of 6s. The period could be controlled by changing the speeds or the dose rate. Conclusion: The work first shows the quantification of the mechanical limits of the couch and the speeds at which the proposed plans begin to deviate. These limits must be kept in mind when programming other couch sequences. The methodology can be used to quantify the limits of other axes. Furthermore, the work shows the possibility of creating 4D respiratory simulations without using specialized phantoms or motion-platforms. This can be further developed to program patient-specific breathing patterns.

  9. Disease management Applying Stylet Oil, Sulforix or

    E-Print Network [OSTI]

    Isaacs, Rufus

    1 Disease management Applying Stylet Oil, Sulforix or Armicarb now to vines with powdery mildew will reduce disease pressure next year. Do not apply Sulforix to sulfur-sensitive grapes. Bunch rots are best controlled by leaf pulling, but application of Fungastop may help reduce sour rot. Insect management Low

  10. What You Should Know About Plant Diseases

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01

    lodge, the grain is shrivelled and yields are low. The disease movement is shown in figure 6. " Seedling Disease ig. 7. See, caused b - -.-!.. ~. &> dling dise; y a comp' L , ase of cot1 lex of mic 11, *L^ -1. .fore its el tter it emf...

  11. Epidemiological-environmental study of diesel bus garage workers: acute effects of NO/sub 2/ and respirable particulate on the respiratory system

    SciTech Connect (OSTI)

    Gamble, J.; Jones, W.; Minshall, S.

    1987-02-01

    Personal samples of nitrogen dioxide (NO/sub 2/) and respirable particulate (RP) were collected over the shift on 232 workers in four diesel bus garages. Response was assessed by an acute respiratory questionnaire and before and after shift spirometry. Measures of exposure to NO/sub 2/ and RP were associated with work-related symptoms of cough; itching, burning, or watering eyes; difficult or labored breathing; chest tightness; and wheeze. The prevalence of burning eyes, headaches, difficult or labored breathing, nausea, and wheeze experienced at work were higher in the diesel bus garage workers than in a comparison population of battery workers, while the prevalence of headaches was reduced. Mean reductions in forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), peak flow, and flows at 50 and 75% of FVC were not obviously different from zero. There was no detectable association of exposure to NO/sub 2/ or respirable particulate and acute reductions in pulmonary function. Workers who often had respiratory work-related symptoms generally had a slightly greater mean acute reduction in FEV1 and FEF50 than did those who did not have these symptoms, but these differences were not statistically significant.

  12. The implications of human metabolic network topology for disease comorbidity

    E-Print Network [OSTI]

    of different (and often disease-causing) genetic and epigenetic variations are not restricted but may spread, certain diseases, such as diabetes and obesity, or Gaucher disease and Parkinson disease, often cooccurThe implications of human metabolic network topology for disease comorbidity D.-S. Lee* , J. Park

  13. Disease Prevention in the Home Garden. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    . 12. Rotation. Avoid soil disease buildup. ?13. Insect control. Prevent virus spread. 14. Proper harvesting. Avoid storage decay. 15. Sanitation. Prevent buildup of diseased plant tissue in garden. 16. Fungicide application. Control diseases should...H to approximately 5.2; 10 Ibs. of sulfur per 1000 sq . ft. d rops the pH .5. Examp le: Ori- ginal pH 7.5; desired pH 5.5; 40 Ibs. of sulfur requ ired to adjust pH 3. Ring rot Bacterium I nfected seed pieces Introduction of Rotation and sanitation Equipment...

  14. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general populationAging is the primary risk factor for the majority of neurodegenerative diseases, including

  15. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population James Parkinson first described the clinical symptoms of Parkinson's disease (PD) in his 1817 monograph

  16. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population array of neurobiological disorders, including Parkinson's disease, epilepsy, essential tremor, Tourette

  17. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  18. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  19. Epidemiology and evolution of Marek’s Disease virus 

    E-Print Network [OSTI]

    Atkins, Katherine E.

    2010-01-01

    Marek’s disease (MD) is an oncogenic disease affecting chickens and is estimated to cost the worldwide poultry industry $1-2 billion annually. The causative agent of MD, Marek’s disease virus (MDV), provides a ...

  20. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  1. Metabolomics reveals metabolic biomarkers of Crohn's disease

    SciTech Connect (OSTI)

    Jansson, J.K.; Willing, B.; Lucio, M.; Fekete, A.; Dicksved, J.; Halfvarson, J.; Tysk, C.; Schmitt-Kopplin, P.

    2009-06-01

    The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.

  2. Management of cotton seedling disease complexes 

    E-Print Network [OSTI]

    Fichtner, Scott Michael

    2001-01-01

    The objective of this research was to evaluate combinations of approaches for the management of seedling diseases of cotton caused by soilborne pathogens, including the use of host resistance. Over 200 cotton lines were ...

  3. MFR PAPER 1208 Minchinia nelsoni (MSX) Disease

    E-Print Network [OSTI]

    of the disease in each of these areas has been thoroughly stud- 22 ied and reported (Haskin et aI., 1965; Andrews, 1966, 1968; Rosenfield and Sindermann, 1966; Andrews and Wood, 1967; Couch and Rosenfield, 1968; Ford

  4. Is chytridiomycosis an emerging disease in Asia?

    E-Print Network [OSTI]

    Brown, Rafe M.

    2011-01-01

    Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic... Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic...

  5. How should environmental stress affect the population dynamics of disease?

    E-Print Network [OSTI]

    Holt, Robert D.

    in pollution (Khan 1990), malnutrition (Beck & Levander 2000) and thermal stress from climate change (Harvell and disease in natural populations. Keywords Disease, dynamics, host, infectious, model, pollution, population

  6. ATTACHMENT 1: HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    : HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM (CBDPP) COMMITTEE CHARTER The Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP) Committee is established...

  7. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease 

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17

    This study assesses generic and disease-specific Health-Related Quality of Life (HRQOL) in children and adolescents with Inflammatory Bowel Disease (IBD). More specifically, the purpose of the study is to address the relationship between disease...

  8. Photo-environment affects disease progression in bacterial artificial chromosome (BAC) Huntington s disease mouse model

    E-Print Network [OSTI]

    HUEI-BIN, WANG,

    2015-01-01

    OF CALIFORNIA Los Angeles Photo-environment affects diseaseABSTRACT OF THE THESIS Photo-environment affects diseaseshow that inappropriate photo-environment such as constant

  9. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  10. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D.

    1996-10-01

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  11. Global disease monitoring and forecasting with Wikipedia

    SciTech Connect (OSTI)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: access logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.

  12. Global disease monitoring and forecasting with Wikipedia

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: accessmore »logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.« less

  13. 788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi

    E-Print Network [OSTI]

    Hsiang, Tom

    788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi that grow and attack limit the activity and number of com- petitors and antagonists of snow mold fungi, and allow these pathogens to mo- nopolize the nutrient-rich but weakened plant tissues (42). Most snow mold fungi that have

  14. An immuno-epidemiological model for Johne's disease in cattle

    E-Print Network [OSTI]

    Martcheva, Maia

    An immuno-epidemiological model for Johne's disease in cattle Maia Martcheva1 Email: maia's disease in dairy cattle, this paper illustrates a novel way to link a within-host model for Mycobacterium reproduction model. Introduction Johne's disease (JD) in dairy cattle is a chronic infectious disease

  15. Investigating the role of bovine herpesvirus-1 in abortion and systemic disease in cattle 

    E-Print Network [OSTI]

    Crook, Tara Catherine

    2011-10-05

    Bovine herpesvirus-1 (BoHV-1) is a pathogen of cattle, which most commonly affects the upper respiratory tract to cause infectious bovine rhinotracheitis (IBR). It can also spread systemically to cause fatalities in ...

  16. interdisciplinary Glyphosate, pathways to modern diseases II

    E-Print Network [OSTI]

    Seneff, Stephanie

    rashes, depression, and nutrient deficiencies. Usually, but not always, a strict gluten-free diet caninterdisciplinary Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North

  17. ISSUE 58 APRIL 2009 Will coeliac disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 58 APRIL 2009 Will coeliac disease always mean gluten-free? Pen-pushers Meet the winning is to deliver a free, Darwin-inspired experiment to every schoolchild in the country. For primary schools, we of the Wellcome Trust Wellcome News Wellcome News is published four times a year and is available free of charge

  18. Centers for Disease Control and Prevention (CDC)

    E-Print Network [OSTI]

    and Terrorism and Director of Global Health Activities for the Division of Environmental Hazards and Health based environmental health assessments #12;Government Agencies Visited · The United States AgencyCenters for Disease Control and Prevention (CDC) National Center for Environmental Health CDC

  19. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  20. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    of plant disease Nematodes alone cost ~$100 billions worldwide In the US, yearly cost ~ $15 billions #12 of temperature 3 Days After #12;#12;Effects of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury

  1. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    In the US, yearly cost ~ $15 billions #12;4/29/2015 15 Impacts of plant disease In a worldwide scale 27 of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury (mechanical abrasion) Effects of temperature

  2. Genetically Determined Height and Coronary Artery Disease

    E-Print Network [OSTI]

    Nelson, Christopher P.; Hamby, Stephen E.; Saleheen, Danish; Hopewell, Jenna C.; Zeng, Lingyao; Assimes, Themistocles L.; Kanoni, Stavroula; Willenborg, Christina; Burgess, Stephen; Amouyel, Philippe; Anand, Sonia; Blankenberg, Stefan; Boehm, Bernhard O.; Clarke, Robert J.; Collins, Rory; Dedoussis, George; Farrall, Martin; Franks, Paul W.; Groop, Leif; Hall, Alistair S.; Hamsten, Anders; Hengstenberg, Christian; Hovingh, G. Kees; Ingelsson, Erik; Kathiresan, Sekar; Kee, Frank; König, Inke R.; Kooner, Jaspal; Lehtimäki, Terho; März, Winifred; McPherson, Ruth; Metspalu, Andres; Nieminen, Markku S.; O'Donnell, Christopher J.; Palmer, Colin N.A.; Peters, Annette; Perola, Markus; Reilly, Muredach P.; Ripatti, Samuli; Roberts, Robert; Salomaa, Veikko; Shah, Svati H.; Schreiber, Stefan; Siegbahn, Agneta; Thorsteinsdottir, Unnur; Veronesi, Giovani; Wareham, Nicholas J.; Willer, Cristen J.; Zalloua, Pierre A.; Erdmann, Jeanette; Deloukas, Panos; Watkins, Hugh; Schunkert, Heribert; Danesh, John; Thompson, John R.; Samani, Nilesh J.

    2015-04-23

    of Tampere, Tampere (T.L.), and the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital (M.S.N.), Department of Chronic Disease Prevention, National Institute for Health and Welfare (M.P., V.S.), and Hjelt Institute The New...

  3. 3301DEVELOPMENT AND DISEASE RESEARCH ARTICLE INTRODUCTION

    E-Print Network [OSTI]

    Gibson, Matt

    smooth muscle cells (SMC) and SM pathology is associated with several diseases, including asthma, lung the urinary bladder, and a failure of this activity causes `functional' flow impairment leading to urinary tract may be an important primary cause of functional obstruction and hydronephrosis. Between mouse

  4. Treatment of Anthrax Disease Frequently Asked Questions

    SciTech Connect (OSTI)

    Judd, Kathleen S.; Young, Joan E.; Lesperance, Ann M.; Malone, John D.

    2010-05-14

    This document provides a summary of Frequently Asked Questions (FAQs) on the treatment of anthrax disease caused by a wide-area release of Bacillus anthracis spores as an act bioterrorism. These FAQs are intended to provide the public health and medical community, as well as others, with guidance and communications to support the response and long-term recovery from an anthrax event.

  5. ISSUE 55 JULY 2008 Genes and disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 55 JULY 2008 FUNDING Genes and disease In this issue... FUNDING AND UPDATES 2­5 Project building, in Kenya, South Africa, Uganda and elsewhere in Africa (see page 5). The largest ever study. The Institute will devote a large part of its high-throughput genotyping pipeline, headed by Dr Panos Deloukas

  6. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Harvell, Catherine Drew

    and disease in Mexico J. R. Ward1,*, K. L. Rypien1 , J. F. Bruno2 , C. D. Harvell1 , E. Jordán-Dahlgren3 , K Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3300, USA 3

  7. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  8. Laterality of Motor Symptom Onset, Disease Progression, and Cognition in Parkinson's Disease

    E-Print Network [OSTI]

    Chau, Phuong My

    2010-08-31

    The current study examined whether laterality of initial motor symptom onset (left-sided onset vs. right-sided onset) in Parkinson's disease (PD) would predict the pattern and/or severity of cognitive deficits measured at ...

  9. Epidemiological-environemental study of lead acid battery workers. III. Chronic effects of sulfuric acid on the respiratory system and teeth

    SciTech Connect (OSTI)

    Gamble, J.; Jones, W.; Hancock, J.; Meckstroth, R.L.

    1984-10-01

    The effects of long-term exposure to sulfuric acid mist on the teeth and respiratory system were studied in 248 workers in five plants manufacturing lead acid batteries. The prevalence of cough, phlegm, dyspnea, and wheezing as determined by questionnaire were not associated with estimates of cumulative acid exposure. There was only one case of irregular opacities seen on the chest radiographs. There was no statistically significant association of reduced FEV/sub 1/ peak flow, FEF/sub 50/, and FEF/sub 75/ with acid exposure although the higher exposed group had lower mean values. FVC in the high exposure group showed a statistically significant reductioon compared to the low exposure group but there was no significant association when exposure was analyzed as a continuous variable. The ratio of observed to expected prevalence of teeth etching and erosion was about four times greater in the high acid-exposure group. The earliest case of etching occured after 4 months exposure to an estimated average exposure of 0.23 mg/m/sup 3/ sulfuric acid.

  10. Associations of indoor carbon dioxide concentrations and environmental susceptibilities with mucous membrane and lower respiratory building related symptoms in the BASE study: Analyses of the 100 building dataset

    SciTech Connect (OSTI)

    Erdmann, Christine A.; Apte, Michael G.

    2003-09-01

    Using the US EPA 100 office-building BASE Study dataset, they conducted multivariate logistic regression analyses to quantify the relationship between indoor CO{sub 2} concentrations (dCO{sub 2}) and mucous membrane (MM) and lower respiratory system (LResp) building related symptoms, adjusting for age, sex, smoking status, presence of carpet in workspace, thermal exposure, relative humidity, and a marker for entrained automobile exhaust. In addition, they tested the hypothesis that certain environmentally-mediated health conditions (e.g., allergies and asthma) confer increased susceptibility to building related symptoms within office buildings. Adjusted odds ratios (ORs) for statistically significant, dose-dependent associations (p < 0.05) for dry eyes, sore throat, nose/sinus congestion, and wheeze symptoms with 100 ppm increases in dCO{sub 2} ranged from 1.1 to 1.2. These results suggest that increases in the ventilation rates per person among typical office buildings will, on average, reduce the prevalence of several building related symptoms by up to 70%, even when these buildings meet the existing ASHRAE ventilation standards for office buildings. Building occupants with certain environmentally-mediated health conditions are more likely to experience building related symptoms than those without these conditions (statistically significant ORs ranged from 2 to 11).

  11. Binding of the Respiratory Chain Inhibitor Antimycin to theMitochondrial bc1 Complex: A New Crystal Structure Reveals an AlteredIntramolecular Hydrogen-Bonding Pattern

    SciTech Connect (OSTI)

    Huang, Li-shar; Cobessi, David; Tung, Eric Y.; Berry, Edward A.

    2005-05-10

    Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial respiratory chain, binds to the quinone reduction site of the cytochrome bc1 complex.Structure-activity-relationship studies have shown that the N-formylamino-salicyl-amide group is responsible for most of the binding specificity, and suggested that a low pKa for the phenolic OH group and an intramolecular H-bond between that OH and the carbonyl O of the salicylamide linkage are important. Two previous X-ray structures of antimycin bound to vertebrate bc1 complex gave conflicting results. A new structure reported here of the bovine mitochondrial bc1 complex at 2.28Angstrom resolution with antimycin bound, allows us for the first time to reliably describe the binding of antimycin and shows that the intramolecular hydrogen bond described in solution and in the small-molecule structure is replaced by one involving the NH rather than carbonyl O of the amide linkage, with rotation of the amide group relative to the aromatic ring. The phenolic OH and formylamino N form H-bonds with conserved Asp228 of cyt b, and the formylamino O H-bonds via a water molecule to Lys227. A strong density the right size and shape for a diatomic molecule is found between the other side of the dilactone ring and the alpha-A helix.

  12. Disease resistance and performance of blended populations of creepi 

    E-Print Network [OSTI]

    Abernathy, Scott David

    1999-01-01

    Plant diseases are a major problem on creeping bentgrass greens and can significantly decrease putting quality. Blended populations comprised of two or more cultivars within the same species have been utilized to decrease disease development...

  13. Goal-directed Behaviour & Apathy in Parkinson's Disease 

    E-Print Network [OSTI]

    Cox, Simon

    2009-11-26

    Apathy has been described as a highly-prevalent symptom of Parkinson's disease that has a significant effect upon quality of life, even when the motor symptoms of the disease are taken into account.

  14. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  15. Mycosphaerella species causing leaf disease in South African Eucalyptus plantations

    E-Print Network [OSTI]

    Mycosphaerella species causing leaf disease in South African Eucalyptus plantations Gavin C. HUNTER Eucalyptus plantations provide an important source of hardwood for forestry industries, worldwide. Several species of Mycosphaerella are associated with a destructive Eucalyptus leaf disease known

  16. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  17. Endemic models for the spread of infectious diseases with arbitrarily ...

    E-Print Network [OSTI]

    SIAM (#1) 1035 1999 Jan 20 12:53:14

    2000-10-03

    have general length distributions and disease survival functions, the different time ..... In order to describe the duration of the various stages and the related disease ...... Approaches to Problems in Resource Management and Epidemiology, ...

  18. Role of the hedgehog signalling pathway in inflammatory bowel disease 

    E-Print Network [OSTI]

    Lees, Charles William

    2009-01-01

    Introduction. The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are common in Western Europe (200-400 cases /100,000) and associated with substantial morbidity, although mortality ...

  19. Measuring human movement for biomechanical applications using markerless motion capture

    E-Print Network [OSTI]

    Sundaresan, Aravind

    in multiple 2D image planes. The three methods are systematically evaluated and results for real data many different fields such as kinesiology, physiotherapy, orthopedic surgery, ergonomics, etc [1 related to musculoskeletal diseases, the development and evaluation of rehabilitative treatments

  20. Nanoscale influences on bioactivity : ultrastructure and nanomechanics of model bioactive hydroxyapatite based biomaterials

    E-Print Network [OSTI]

    Vandiver, Jennifer M. (Jennifer McKeehan)

    2006-01-01

    There is a significant need for improved synthetic materials as orthopedic implants to replace human bone lost and damaged due to disease or injury. Certain ceramics, such as hydroxyapatite (HA), have the special property ...

  1. Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms Molecular mechanisms of aging-related neurodegenerative diseases: emerging views

    E-Print Network [OSTI]

    Breitling, Rainer

    , including Parkinson's disease, polyglutamine expansion diseases and Alzheimer's disease, are associated used to model these diseases and high throughput genetic screens using these models have led-analysis #12;3 Introduction Several age-related neurodegenerative diseases, including Parkinson's disease

  2. (See reverse side) Information about Meningococcal Disease and Vaccination

    E-Print Network [OSTI]

    Dennett, Daniel

    is infected and is coughing or sneezing. Who is at most risk for getting meningococcal disease? High

  3. Exploring Disease Transmission On Networks with Winfried Just

    E-Print Network [OSTI]

    Just, Winfried

    the relevant contact network, depends on the particular disease. Think of the flu vs. a computer virus vs of disease transmission Infectious diseases are caused by pathogens (such as viruses, bacteria, fungi identical. Such models can be embodied in computer code as agent-based models. Winfried Just and Ying Xin

  4. Disease transmission by cannibalism: rare event or common occurrence?

    E-Print Network [OSTI]

    Antonovics, Janis

    Disease transmission by cannibalism: rare event or common occurrence? Volker H. W. Rudolf Cannibalism has been documented as a possible disease transmission route in several species, including humans. However, the dynamics resulting from this type of disease transmission are not well understood. Using

  5. Neurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity

    E-Print Network [OSTI]

    Lübbert, Hermann

    . Introduction Parkinson's disease (PD) is a major neurodegenerative disease characterized by the degenerationNeurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity Ji Won Um,1 Eunju Im,1-University Bochum, D-44780 Bochum, Germany, and 4Biofrontera Bioscience GmbH, D-51377 Leverkusen, Germany Parkinson

  6. Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response

    E-Print Network [OSTI]

    Sulzer, David

    in a wide range of toxin-based, inflammatory and genetic Parkinson's disease animal models. KeywordsNeuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step neuroin- flammatory processes are exacerbated in Parkinson's disease, including glial- mediated reactions

  7. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases

    E-Print Network [OSTI]

    Bellugi, Ursula

    such as Parkinson's disease and amyotrophic lateral sclerosis where patients' cells have been successfully repro the end-stage of the disease. Mouse models provide a means to mimic human genetic forms of diseases. Owingto tech- nical challenges, species differences and genetic background, even neurologic

  8. Emerging infectious diseases of plants: pathogen pollution, climate change

    E-Print Network [OSTI]

    Schweik, Charles M.

    Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology, Boston, MA 02115, USA Emerging infectious diseases (EIDs) pose threats to conservation and public health a series of emerging plant diseases. We include EIDs of cultivated and wild plants, some of which

  9. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  10. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  11. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  12. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease 

    E-Print Network [OSTI]

    Phillips, Anne Mairead

    2011-07-05

    The inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract. Their aetiology is not fully understood but is thought ...

  13. An investigation of the genetic determinants of succeptibility and disease behavoir in early onset Inflammatory Bowel Disease in Scottish children. 

    E-Print Network [OSTI]

    Russell, Richard K

    2008-01-01

    A series of investigations examining the importance of genetic factors in the development of the inflammatory bowel diseases (IBD) namely Crohn’s disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC) has ...

  14. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  15. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  16. Understanding diseases at a molecular level

    SciTech Connect (OSTI)

    Rosev, Tatjana K [Los Alamos National Laboratory

    2008-01-01

    A group of scientists at Los Alamos National Laboratory in 2008 successfully pioneered a microscope able to track protein-sized, hard to see particles in three dimensions. The 3D Tracking Microscope, designed and developed by James H. Werner, Guillaume A. Lessard, Nathan Wells and Peter M. Goodwin of LANL's Center for Integrated Nanotechnologies, won a 2008 R&D 100 award. The team's invention is a unique confocal 3D tracking microscope capable of following the motion of nanometer-sized objects, such as individual molecules, quantum dots, organic fluorophores and single green fluorescent proteins as they zoom through three-dimensional space at rates faster than many intracellular transport processes. The 3D tracking microscope can follow the transport of nanometer-sized particles at micrometer per second rates. This enables researchers to follow individual protein, ribonucleic acid (RNA), or deoxyribonucleic acid (DNA) motion throughout the full three-dimensional volume of a cell to discover the path a particular biomolecule takes, the method it employs to get there and the specific proteins it may be interacting with along the way. In addition to applications in molecular spectroscopy and materials research, the 3D tracking microscope is a powerful tool primarily in the fields of cellular biology and biomedical research, Werner said. 'The 3D tracking microscope will advance our understanding of the molecular basis and kinetics of many diseases, such as cancer, diabetes, or muscular dystrophy,' he said. 'We anticipate the microscope will become a valuable weapon in the arsenal of biomedical researchers who are fighting to find cures for cancer, heart disease and other protein or DNA-based diseases.'

  17. Isotoxic Dose Escalation in the Treatment of Lung Cancer by Means of Heterogeneous Dose Distributions in the Presence of Respiratory Motion

    SciTech Connect (OSTI)

    Baker, Mariwan; Nielsen, Morten [Laboratory of Radiation Physics, Odense University Hospital, Odense (Denmark); Hansen, Olfred [Department of Oncology, Odense University Hospital, Odense (Denmark); Jahn, Jonas Westberg [Laboratory of Radiation Physics, Odense University Hospital, Odense (Denmark); Korreman, Stine [Department of Radiation Oncology, Copenhagen University Hospital, Copenhagen (Denmark); Brink, Carsten, E-mail: carsten.brink@ouh.regionsyddanmark.dk [Laboratory of Radiation Physics, Odense University Hospital, Odense (Denmark); Institute of Clinical Research, University of Southern Denmark, Odense (Denmark)

    2011-11-01

    Purpose: To test, in the presence of intrafractional respiration movement, a margin recipe valid for a homogeneous and conformal dose distribution and to test whether the use of smaller margins combined with heterogeneous dose distributions allows an isotoxic dose escalation when respiratory motion is considered. Methods and Materials: Twenty-three Stage II-III non-small-cell lung cancer patients underwent four-dimensional computed tomography scanning. The gross tumor volume and clinical target volume (CTV) were outlined in the mid-ventilation phase. The CTV-to-planning target volume (PTV) margin was calculated by use of a standard margin recipe and the patient-specific respiration pattern. Standard three-dimensional treatment plans were generated and recalculated on the remaining respiration phases. The planning was repeated for a CTV-to-PTV margin decreased by 2.5 and 5 mm relative to the initial margin in all directions. Time-averaged dose-volume histograms (four-dimensional dose-volume histograms) were calculated to evaluate the CTV-to-PTV margin. Finally, the dose was escalated in the plans with decreased PTV such that the mean lung dose (predictor of radiation-induced pneumonitis) was equal to mean lung dose in the plan by use of the initially calculated margin. Results: A reduction of the standard margin by 2.5 mm compared with the recipe resulted in too low of a minimum dose for some patients. A combination of dose escalation and use of heterogeneous dose distribution was able to increase the minimum dose to the target by approximately 10% and 20% for a CTV-to-PTV margin reduction of 2.5 mm and 5.0 mm, respectively. Conclusion: The margin recipe is valid for intrafractional respiration-induced tumor motions. It is possible to increase the dose to the target without increased mean lung dose with an inhomogeneous dose distribution.

  18. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  19. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  20. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  1. PERIORAL BIOMECHANICS, KINEMATICS, AND ELECTROPHYSIOLOGY IN PARKINSON'S DISEASE

    E-Print Network [OSTI]

    Chu, Shin Ying

    2010-11-21

    This investigation quantitatively characterized the orofacial biomechanics, labial kinematics, and associated electromyography (EMG) patterns in individuals with Parkinson's disease (PD) as a function of anti-PD medication ...

  2. Structure of the Newcastle disease virus hemagglutinin-neuraminidase...

    Office of Scientific and Technical Information (OSTI)

    of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk Citation Details In-Document Search Title: Structure of the Newcastle...

  3. Proteins' Amazing Origami Powers: Insight for Potential Disease...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Senior Writer, Office of Science What are the key facts? Better knowledge of protein folding could in turn provide more insight into the diseases associated with malformed...

  4. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  5. Psoriasis disease severity affects patient satisfaction with treatment

    E-Print Network [OSTI]

    Korman, Neil J; Zhao, Yang; Lu, Jackie; Tran, Mary Helen

    2015-01-01

    among patients with psoriasis and psoriatic arthritis in thefindings from the National Psoriasis Foundation surveys,J. Mechanism of disease: psoriasis. N Engl J Med. 2009;361(

  6. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  7. AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS...

    Office of Scientific and Technical Information (OSTI)

    Converting energy to medical progress nuclear medicine NONE 62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS; NUCLEAR MEDICINE; PATIENTS; RADIATION...

  8. Bacteria Associated With Colitis and Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Ye, Jingxiao

    2009-01-01

    bowel diseases: antibiotics, probiotics, and prebiotics."clinical trial of probiotics (Lactobacillus johnsonii, LA1)Besides antibiotics, probiotics might also be a potential

  9. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  10. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  11. Fish oil can help reduce deaths from heart disease,

    E-Print Network [OSTI]

    Shen, Jun

    Fish oil can help reduce deaths from heart disease, according to new evidence reports announced- ute to heart disease. The review also found other evidence indicating that fish oil can help lower in knowledge." Continued, page 2... Evidence Reports Confirm Benefits of Fish Oil Elizabeth Yetley, PhD Joins

  12. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  13. Epidemiology / pidmiologie Climate change and plant diseases in Ontario

    E-Print Network [OSTI]

    Boland, Greg J.

    Epidemiology / Épidémiologie Climate change and plant diseases in Ontario G.J. Boland, M.S. Melzer in Ontario will significantly affect the occurrence of plant diseases in agriculture and forestry management plans. Adaptations in agriculture and forestry have been occurring in Ontario for over 100 years

  14. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  15. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  16. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

    E-Print Network [OSTI]

    Sulzer, David

    State Psychiatric Institute, New York City, NY 10032, USA Parkinson's disease arises from geneticMultiple hit hypotheses for dopamine neuron loss in Parkinson's disease David Sulzer Departments features. Although many genetic mutations have been suggested as causes or risk factors for Parkinson

  17. Ash dieback disease www.forestry.gov.uk/planthealth

    E-Print Network [OSTI]

    Ash dieback disease www.forestry.gov.uk/planthealth Pest Alert Distribution In Britain, most of the outbreaks of ash dieback disease in the natural environment are confined to East Anglia and Kent, although a small number of outlying cases have been confirmed in northeast England and Scotland. Common ash

  18. Chronic Beryllium Disease Prevention Environment, Safety, Health, and Quality Division

    E-Print Network [OSTI]

    Wechsler, Risa H.

    Chronic Beryllium Disease Prevention Program Environment, Safety, Health, and Quality Division SLAC-I-730-0A09M-001-R003 24 September 2013 #12;Publication Data This document was developed by the Beryllium program and published by ESHQ Publishing. Document Title: Chronic Beryllium Disease Prevention Program

  19. Economic Consideration of Mitigation of Foreign Animal Disease Introduction *

    E-Print Network [OSTI]

    McCarl, Bruce A.

    Economic Consideration of Mitigation of Foreign Animal Disease Introduction * Levan Elbakidze, Bruce A. McCarl Department of Agricultural Economics National Center for Foreign Animal and Zoonotic Disease Defense (FAZDD), Texas A&M University, College Station TX, USA The economic implications

  20. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  1. Research Fund for the Prevention and Treatment of Kidney Disease

    E-Print Network [OSTI]

    Weber, David J.

    and economic costs associated with these diseases. UMMC accommodates one million patient visits a year With a reputation for innovation and technical and surgical excellence, the UMSOM Division of Transplantation is one global cost for treatment of kidney disease in terms of dialysis and transplantation over the next decade

  2. Development and Characterization of A Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out

    SciTech Connect (OSTI)

    Smith, S M; Danganan, L; Tammero, L; Vitalis, B; Lenhoff, R; Naraghi-arani, P; Hindson, B

    2007-08-06

    Lawrence Livermore National Laboratory (LLNL), in collaboration with the Department of Homeland Security (DHS) and the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Services (APHIS) has developed candidate multiplexed assays that may potentially be used within the National Animal Health Laboratory Network (NAHLN), the National Veterinary Services Laboratory (Ames, Iowa) and the Plum Island Animal Disease Center (PIADC). This effort has the ability to improve our nation's capability to discriminate between foreign animal diseases and those that are endemic using a single assay, thereby increasing our ability to protect food and agricultural resources with a diagnostic test which could enhance the nation's capabilities for early detection of a foreign animal disease. In FY2005 with funding from the DHS, LLNL developed the first version (Version 1.0) of a multiplexed (MUX) nucleic-acid-based RT-PCR assay that included signatures for foot-and-mouth disease virus (FMDV) detection with rule-out tests for two other foreign animal diseases (FADs) of swine, Vesicular Exanthema of Swine (VESV) and Swine Vesicular Disease Virus (SVDV), and four other domestic viral diseases Bovine Viral Diarrhea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1), Bluetongue virus (BTV) and Parapox virus complex (which includes Bovine Papular Stomatitis Virus [BPSV], Orf of sheep, and Pseudocowpox). In FY06, LLNL has developed Bovine and Porcine species-specific panel which included existing signatures from Version 1.0 panel as well as new signatures. The MUX RT-PCR porcine assay for detection of FMDV includes the FADs, VESV and SVD in addition to vesicular stomatitis virus (VSV) and porcine reproductive and respiratory syndrome (PRRS). LLNL has also developed a MUX RT-PCR bovine assay for detection of FMDV with rule out tests for the two bovine FADs malignant catarrhal fever (MCF), rinderpest virus (RPV) and the domestic diseases vesicular stomatitis virus (VSV), bovine viral diarrhea virus (BVDV), infectious bovine rhinotracheitus virus (BHV-1), bluetongue virus (BTV), and the Parapox viruses (which are of two bovine types) bovine papular stomatitis virus (BPSV) and psuedocowpox (PCP). A timeline for this development is presented in Table 1. The development of the Version 1.0 panel for FMDV rule-out and the most current efforts aimed to designed species specific panels has spanned over 2 1/2 years with multiple collaborative partnerships. This document provides a summary of the development, testing and performance data at OIE Stage 1 Feasibility into Stage 2 Assay Development and Standardization1 (see Table 2), gathered as of June 30th, 2007 for the porcine and bovine MUX assay panels. We present an overview of the identification and selection of candidate genetic signatures, the assay development process, and preliminary performance data for each of the individual signatures as characterized in the multiplexed format for the porcine and bovine panels. The Stage 1 Feasibility data of the multiplexed panels is presented in this report also includes relevant data acquired from the Version 1.0 panel as supporting information where appropriate. In contrast to last years effort, the development of the bovine and porcine panels is pending additional work to complete analytical characterization of FMDV, VESV, SVD, RPV and MCF. The signature screening process and final panel composition impacts this effort. The unique challenge presented this year was having strict predecessor limitations in completing characterization, where efforts at LLNL must precede efforts at PIADC, such challenges were alleviated in the 2006 reporting by having characterization data from the interlaboratory comparison and at Plum Island under AgDDAP project. We will present an addendum at a later date with additional data on the characterization of the porcine and bovine multiplex assays when that data is available. As a summary report, this document does not provide the details of signature generation, evaluation, and testing, nor does it provide spec

  3. Development and Characterization of a Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out Supplemental Materials

    SciTech Connect (OSTI)

    Smith, S; Danganan, L; Tammero, L; Lenhoff, R; Naraghi-arani, P; Hindson, B

    2007-08-06

    Lawrence Livermore National Laboratory (LLNL), in collaboration with the Department of Homeland Security (DHS) and the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Services (APHIS) has developed advanced rapid diagnostics that may be used within the National Animal Health Laboratory Network (NAHLN), the National Veterinary Services Laboratory (Ames, Iowa) and the Plum Island Animal Disease Center (PIADC). This effort has the potential to improve our nation's ability to discriminate between foreign animal diseases and those that are endemic using a single assay, thereby increasing our ability to protect animal populations of high economic importance in the United States. Under 2005 DHS funding we have developed multiplexed (MUX) nucleic-acid-based PCR assays that combine foot-and-mouth disease virus (FMDV) detection with rule-out tests for two other foreign animal diseases Vesicular Exanthema of Swine (VESV) and Swine Vesicular Disease (SVD) and four other domestic viral diseases Bovine Viral Diarrhea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1 or Infectious Bovine Rhinotracheitus IBR), Bluetongue virus (BTV) and Parapox virus complex (which includes Bovine Papular Stomatitis Virus BPSV, Orf of sheep, and Pseudocowpox). Under 2006 funding we have developed a Multiplexed PCR [MUX] porcine assay for detection of FMDV with rule out tests for VESV and SVD foreign animal diseases in addition to one other domestic vesicular animal disease vesicular stomatitis virus (VSV) and one domestic animal disease of swine porcine reproductive and respiratory syndrome (PRRS). We have also developed a MUX bovine assay for detection of FMDV with rule out tests for the two bovine foreign animal diseases malignant catarrhal fever (MCF), rinderpest virus (RPV) and the domestic diseases vesicular stomatitis virus (VSV), bovine viral diarrhea virus (BVDV), infectious bovine rhinotracheitus virus (BHV-1), bluetongue virus (BTV), and the Parapox viruses which are of two bovine types bovine papular stomatitis virus (BPSV) and psuedocowpox (PCP). This document provides details of signature generation, evaluation, and testing, as well as the specific methods and materials used. A condensed summary of the development, testing and performance of the multiplexed assay panel was presented in a 126 page separate document, entitled 'Development and Characterization of A Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out'. This supplemental document provides additional details of large amount of data collected for signature generation, evaluation, and testing, as well as the specific methods and materials used for all steps in the assay development and utilization processes. In contrast to last years effort, the development of the bovine and porcine panels is pending additional work to complete analytical characterization of FMDV, VESV, VSV, SVD, RPV and MCF. The signature screening process and final panel composition impacts this effort. The unique challenge presented this year was having strict predecessor limitations in completing characterization, where efforts at LLNL must preceed efforts at PIADC, such challenges were alleviated in the 2006 reporting by having characterization data from the interlaboratory comparison and at Plum Island under AgDDAP project. We will present an addendum at a later date with additional data on the characterization of the porcine and bovine multiplex assays when that data is available.

  4. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK

    E-Print Network [OSTI]

    Sulzer, David

    and 2 Department of Neurology, Center for Parkinson's Disease and Other Movement Disorders, Columbia Disease, polyglutamine disease (CAG repeat), and Parkinson disease (10). Ã To whom correspondence shouldAutophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and m

  5. Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency 

    E-Print Network [OSTI]

    Lee, Thomas A.; Krausz, Joseph P.

    2006-04-13

    to be healthy and vigor- ous and for nut quality and yield to be satisfactory, producers must establish sound disease-management programs. Producers can pre- vent losses from diseases and insuff_i cient zinc by implementing ef_fective grove management... fall. Although the foliage is mature and no longer susceptible to the scab fun- gus, the shucks surrounding the nuts are immature and vulnerable to late-season infections. Factors inf_l uencing disease development As you develop a spray program...

  6. Adaptation of the modified Bouc–Wen model to compensate for hysteresis in respiratory motion for the list-mode binning of cardiac SPECT and PET acquisitions: Testing using MRI

    SciTech Connect (OSTI)

    Dasari, Paul K. R.; Shazeeb, Mohammed Salman [Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655 and Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609 (United States); Könik, Arda; Lindsay, Clifford; Mukherjee, Joyeeta M.; Johnson, Karen L.; King, Michael A., E-mail: Michael.King@umassmed.edu [Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655 (United States)

    2014-11-01

    Purpose: Binning list-mode acquisitions as a function of a surrogate signal related to respiration has been employed to reduce the impact of respiratory motion on image quality in cardiac emission tomography (SPECT and PET). Inherent in amplitude binning is the assumption that there is a monotonic relationship between the amplitude of the surrogate signal and respiratory motion of the heart. This assumption is not valid in the presence of hysteresis when heart motion exhibits a different relationship with the surrogate during inspiration and expiration. The purpose of this study was to investigate the novel approach of using the Bouc–Wen (BW) model to provide a signal accounting for hysteresis when binning list-mode data with the goal of thereby improving motion correction. The study is based on the authors’ previous observations that hysteresis between chest and abdomen markers was indicative of hysteresis between abdomen markers and the internal motion of the heart. Methods: In 19 healthy volunteers, they determined the internal motion of the heart and diaphragm in the superior–inferior direction during free breathing using MRI navigators. A visual tracking system (VTS) synchronized with MRI acquisition tracked the anterior–posterior motions of external markers placed on the chest and abdomen. These data were employed to develop and test the Bouc–Wen model by inputting the VTS derived chest and abdomen motions into it and using the resulting output signals as surrogates for cardiac motion. The data of the volunteers were divided into training and testing sets. The training set was used to obtain initial values for the model parameters for all of the volunteers in the set, and for set members based on whether they were or were not classified as exhibiting hysteresis using a metric derived from the markers. These initial parameters were then employed with the testing set to estimate output signals. Pearson’s linear correlation coefficient between the abdomen, chest, average of chest and abdomen markers, and Bouc–Wen derived signals versus the true internal motion of the heart from MRI was used to judge the signals match to the heart motion. Results: The results show that the Bouc–Wen model generated signals demonstrated strong correlation with the heart motion. This correlation was slightly larger on average than that of the external surrogate signals derived from the abdomen marker, and average of the abdomen and chest markers, but was not statistically significantly different from them. Conclusions: The results suggest that the proposed model has the potential to be a unified framework for modeling hysteresis in respiratory motion in cardiac perfusion studies and beyond.

  7. PrPSc complexity in different forms of Creutzfeldt-Jakob disease identified using biochemical approaches 

    E-Print Network [OSTI]

    Choi, Young Pyo

    2010-01-01

    Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative diseases affecting humans and animal species. Prion diseases are characterized by the conversion of the host encoded ...

  8. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN RESIDENTIAL BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Buildings H M N DISEASE FROM RADON EXPOSURES: U A THE IMPACTVent 78-6 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OFof conservation measures on radon levels, and the disease

  9. Tackling Africa's chronic disease burden: from the local to the global

    E-Print Network [OSTI]

    de-Graft Aikins, Ama; Unwin, Nigel; Agyemang, Charles; Allotey, Pascale; Campbell, Catherine; Arhinful, Daniel

    2010-04-19

    Abstract Africa faces a double burden of infectious and chronic diseases. While infectious diseases still account for at least 69% of deaths on the continent, age specific mortality rates from chronic diseases as a whole are actually higher in sub...

  10. Speaker for Nov. 1 Lecture to Discuss Deadliest Viral Diseases...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    These studies have led her from the U.S. Centers for Disease Control and Prevention to Lyon, France, where she was instrumental in designing, constructing and making operational a...

  11. Interpreting noncoding genetic variation in complex traits and human disease

    E-Print Network [OSTI]

    Kellis, Manolis

    Association studies provide genome-wide information about the genetic basis of complex disease, but medical research has focused primarily on protein-coding variants, owing to the difficulty of interpreting noncoding ...

  12. Striatal origin of the pathologic beta oscillations in Parkinson's disease

    E-Print Network [OSTI]

    Boyden, Edward Stuart

    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

  13. Superspreading and the impact of individual variation on disease emergence

    E-Print Network [OSTI]

    Getz, Wayne M.

    1 Superspreading and the impact of individual variation on disease emergence Supplementary.................................................................................................................................. 4 1.1 Factors contributing to variation in infectiousness 2.2.2 Parameter estimation from mean and proportion of zeros .................................... 8

  14. Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses

    E-Print Network [OSTI]

    Wurtman, Richard Jay

    The loss of hippocampal and cortical synapses, resulting from impaired synaptogenesis, accelerated synaptic degeneration, or both, is one of the earliest neuropathologic findings in Alzheimer’s Disease and is the finding ...

  15. Introduction Multiple sclerosis (MS) is an inflammatory disease of the

    E-Print Network [OSTI]

    Strominger, Jack L.

    Introduction Multiple sclerosis (MS) is an inflammatory disease of the CNS affecting 0 the frequency of relapses by 30% in relapsing-remitting multiple sclerosis (MS) patients. In the present study

  16. Computational and experimental studies of collagen and related diseases

    E-Print Network [OSTI]

    Yang, Chen, M. Eng. Massachusetts Institute of Technology

    2005-01-01

    Collagen is the most abundant proteins in mammals, and collagen degradation is a process that may be associated with many diseases. In this research we use collagen-like peptides that model both cleavage and noncleavage ...

  17. A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE 

    E-Print Network [OSTI]

    Newton, Billy W.

    2010-01-16

    Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease and is characterized by the accumulation of fat in the liver. AS is considered clinically benign as it is reversible, ...

  18. Peptide immunotherapy in models of allergic airways disease 

    E-Print Network [OSTI]

    MacKenzie, Karen Joan

    2011-11-25

    Allergen-reactive CD4+ T cells are implicated in the pathogenesis of allergic disease. Peptide immunotherapy (PIT) involves therapeutic administration of short immunodominant peptides from within the protein allergen to ...

  19. Ecologic niche modeling and spatial patterns of disease transmission

    E-Print Network [OSTI]

    Peterson, A. Townsend

    2006-12-01

    Ecologic niche modeling (ENM) is a growing field with many potential applications to questions regarding the geography and ecology of disease transmission. Specifically, ENM has the potential to inform investigations concerned ...

  20. Biological studies and characterization of the High Plains Disease pathogen 

    E-Print Network [OSTI]

    Mirabile, Joanna

    2001-01-01

    High Plains Disease (HPD), which is a recently recognized affliction causing up to 80% yield losses in corn and wheat, has been suspected to be of viral origin, however no clear evidence existed to validate this claim. ...

  1. Parenting styles, peer influences, and adolescent cardiovascular disease risk factors 

    E-Print Network [OSTI]

    Tramm, Amy Bishop

    2000-01-01

    Parenting and friendship styles were examined as indicators for obesity and risk of cardiovascular disease in 54 Texas adolescents. This study investigated the relationship between parental and peer influences on obesity ...

  2. Cognitive change in motor neurone disease : evidence of orbitofrontal dysfunction 

    E-Print Network [OSTI]

    McNeill, Ewan

    2006-01-01

    This study examines the presence of cognitive changes in amyotrophic lateral sclerosis (ALS), a subtype of motor neurone disease. Past research has shown executive dysfunction in patients with ALS and frontotemporal ...

  3. Marek’s disease virus pathogenesis and latency 

    E-Print Network [OSTI]

    Hunter, Gillian

    2012-11-30

    Marek’s Disease virus (MDV) is a highly contagious, widespread and persistent neoplastic ?-herpesvirus causing extensive lymphoblastic tumours in chickens. The virus is shed in feather dust and spread through inhalation. ...

  4. Nature of language impairment in motor neurone disease 

    E-Print Network [OSTI]

    Rewaj, Phillipa Jane

    2014-07-01

    Background: Language impairment associated with Motor Neurone Disease (MND) has been documented since the late 19th century, yet little is understood about the pervasiveness or nature of these deficits. The common clinical ...

  5. GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA

    E-Print Network [OSTI]

    Ullrich, Paul

    GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA Anthracnose Angular Leaf on the underside of the leaf is one of the most recognizable signs of bacterial infection on strawberry leaves

  6. Disease marketing and patient coping : a research study

    E-Print Network [OSTI]

    Lau, Hew Mun

    2012-01-01

    BACKGROUND: There is a high prevalence of disease marketing actions in the United States that are targeted towards patients with chronic illness. However, no study has assessed the direct effects of these marketing actions ...

  7. Transforming South–South Technical Support to Fight Noncommunicable Diseases

    E-Print Network [OSTI]

    Shakow, Aaron D.A.

    At the UN High-Level Meeting on non-communicable diseases (NCD) in September 2011, each member state was challenged to create a multisectoral national policy and plan for the prevention and control of non-communicable ...

  8. Polyamine pathway contributes to the pathogenesis of Parkinson disease

    E-Print Network [OSTI]

    Lewandowski, Nicole M.

    The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify ...

  9. Interactive Whole-Heart Segmentation in Congenital Heart Disease

    E-Print Network [OSTI]

    Pace, Danielle Frances

    We present an interactive algorithm to segment the heart chambers and epicardial surfaces, including the great vessel walls, in pediatric cardiac MRI of congenital heart disease. Accurate whole-heart ...

  10. Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease

    E-Print Network [OSTI]

    Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease Christian Habeck January 2008 Available online 14 February 2008 We performed univariate and multivariate discriminant univariate and multivariate analyses produced markers with high classification accuracy in the derivation

  11. Food, Poverty and Epidemic Disease, Edinburgh: 1840-1850 

    E-Print Network [OSTI]

    MacGillivray, Neil

    2004-01-01

    The thesis first examines the link between nutrition and disease, focusing on the poor of Edinburgh during the 184Os, a time of economic depression and food shortage. The development of nutritional science and the level ...

  12. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  13. Strategic Global Alliances in Vaccine Development and Disease Control

    E-Print Network [OSTI]

    Schnaufer, Achim

    Strategic Global Alliances in Vaccine Development and Disease Control Dr Sadhana Sharma BBSRC · UK veterinary vaccinology network · Global veterinary vaccinology alliance #12;3 COORDINATION public engagement on bioscience What we do: #12;"Global Strategic Alliances for the Coordination

  14. Neuroimaging of Discourse Processing in Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Wang, Clarice

    2011-12-31

    Detection of very early stages of Alzheimer's Disease (AD) has been an area of difficulty for researchers due to confounds with age. Prose recall has been suggested as a diagnostically sensitive test of episodic memory declines in AD; however...

  15. Timing of testing and treatment for asymptomatic diseases

    SciTech Connect (OSTI)

    K?rk?zlar, Eser; Faissol, Daniel M.; Griffin, Paul M.; Swann, Julie L.

    2010-07-01

    Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision Process (MDP) model for a simple class of asymptomatic diseases in order to provide the building blocks for analysis of a more general class of diseases. We provide a computationally efficient method for determining a cost-effective dynamic intervention strategy that takes into account (i) the results of the previous test for each individual and (ii) the change in the individual’s behavior based on awareness of the disease. We demonstrate the usefulness of the approach by applying the results to screening decisions for Hepatitis C (HCV) using medical data, and compare our findings to current HCV screening recommendations.

  16. Medicating race : heart disease and durable preoccupations with difference

    E-Print Network [OSTI]

    Pollock, Anne, 1975-

    2007-01-01

    This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

  17. Mechanisms of disease pathogenesis in Spinal Muscular Atrophy 

    E-Print Network [OSTI]

    Mutsaers, Chantal

    2014-06-28

    Low levels of survival motor neuron (SMN) protein cause the autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA), through mechanisms that are poorly defined. SMN protein is ubiquitously expressed, ...

  18. Field Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Taubenhaus, J. J. (Jacob Joseph)

    1919-01-01

    the diseases of the sweet potato. Instead, the corrosive sub: mate treatment should be resorted to because of its efficiency as a fun$ cide arid because of the stimulating effect which it exerts on the resul ing sprouts. After carefully selecting the seed... sweet potatoes for shape (Fig. 1) and discarding all the "shoe strings" (Fig. 2), they should be disinfected with corrosive sublimate solution. This treatment aims at killing the spores of the various disease producing organisms which adhere...

  19. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  20. Characterization of Resistance to Black Spot Disease of Rosa Spp. 

    E-Print Network [OSTI]

    Dong, Qianni

    2014-12-01

    Young-Ki Jo Joshua Yuan Head of Department, Daniel R. Lineberger December 2014 Choose an item. Choose an item. Major Subject: Horticulture Copyright.... These trials typically last 2-3 years to ensure sufficient disease pressure to properly assess the resistance of the plants (Carlson-Nilsson, 2000; Noack, 2003; Shupert, 2005). Lab based detached leaf 4 assay (DLA) is a tool for observing disease...

  1. The inflammatory response in transgastric surgery: gastric content leak leads to localized inflammatory response and higher adhesive disease

    E-Print Network [OSTI]

    2010-01-01

    response and higher adhesive disease Sonia L. Ramamoorthy Æin?ammatory markers, adhesive disease, and morbidity.cantly higher rate of adhesive disease in the SG compared

  2. GridQTL: HIGH PERFORMANCE QTL ANALYSIS VIA THE GRID

    E-Print Network [OSTI]

    Obbard, Darren

    , a hereditary chronic respiratory disease that causes wheezing and coughing in horses world-wide. The condition

  3. Thoracic irradiation in Hodgkin's disease: Disease control and long-term complications

    SciTech Connect (OSTI)

    Tarbell, N.J.; Thompson, L.; Mauch, P. (Harvard Medical School, Boston, MA (USA))

    1990-02-01

    A total of 590 patients with Stage IA-IIIB Hodgkin's disease received mantle irradiation at the Joint Center for Radiation Therapy between April 1969 and December 1984 as part of their initial treatment. Recurrence patterns as well as pulmonary, cardiac and thyroid complications were analyzed. Pulmonary recurrence was more frequently seen in patients with large mediastinal adenopathy (LMA); 11% of patients with LMA recurred in the lung in contrast to 3.1% with small or no mediastinal disease, p = 0.003. Hilar involvement, when corrected for size of mediastinal involvement, was not predictive of lung relapse. Patients with LMA also had a high rate of nodal relapse above the diaphragm (40%) following radiation therapy (RT) alone as compared to similarly treated patients with small or no mediastinal adenopathy (6.5%), p less than 0.0001. This risk of nodal recurrence was greatly reduced (4.7%) for LMA patients receiving combined radiation therapy and chemotherapy (CMT), p less than 0.0001. Sixty-seven patients (11%) with hilar or large mediastinal involvement received prophylactic, low dose, whole lung irradiation. No decrease in the frequency of lung recurrence was seen with the use of whole lung irradiation. Radiation pneumonitis was seen in 3% of patients receiving radiation therapy alone. In contrast, the use of whole lung irradiation was associated with a 15% risk of pneumonitis, p = 0.006. The risk of pneumonitis was also significantly increased with the use of chemotherapy (11%), p = 0.0001. Cardiac complications were uncommon with pericarditis being the most common complication (2.2%). Thyroid dysfunction was seen in 25% of patients and appeared to be age-related. These data suggest that the long-term complications of mantle irradiation are uncommon with the use of modern radiotherapeutic techniques.

  4. Textile-Based Sensor Development for the Continuous Monitoring of Proper Orthopedic Cast Fit

    E-Print Network [OSTI]

    Umsted, Carson Andrew

    2013-01-01

    Evaluation .. 13 Chapter 3: Sensorforce sensor worked very well in the evaluation phase andthe sensor performance was good in initial evaluation, to be

  5. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    tantalum: changes with oxide layer and hydroxyapatite at theTantalum - Changes with Oxide Layer and Hydroxyapatite atand pH), the solid oxide layer can be either compact, or

  6. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    applications. Solar Energy Materials and Solar Cells, 2006.arrays: Fabrication, material properties, and solar energysolar energy, water splitting, and the biomedical materials

  7. SmartCast - Novel Textile Sensors for Embedded Pressure Sensing of Orthopedic Casts

    E-Print Network [OSTI]

    Danilovic, Andrew

    2013-01-01

    set_sleep_mode(SLEEP_MODE_PWR_DOWN); //enter Power-down Mode4 #define SEL2_PB0 8 #define SEL1_PD7 7 #define PWR_CTRL_PINPD5 #define PWR_CTRL_SD_CARD 6 //SmartCast bitFields for

  8. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    Properties of TiO2 Nanotubes. Solid State Phenomena, 2010.and A. Bandyopadhyay, TiO2 nanotubes on Ti: Influence of2075. Macak, J.M. , et al. , TiO2 nanotubes: Self-organized

  9. A Novel Wireless Health Orthopedic System Integrating Motion and Acoustic Emission Monitoring

    E-Print Network [OSTI]

    Paul, Manda

    2013-01-01

    mems/gyro/mpu9150.html›. [17] Nine-Axis Sensor Fusion UsingBoard Sensor: MPU-9150 o Triple-axis MEMS gyroscope,Sensor; 16-bit ADC; Digital Motion Processor; 9 axis MEMS;

  10. Evaluation of Biomimetic and Alloy-based Materials for Orthopedic Applications 

    E-Print Network [OSTI]

    Guiza-Arguello, Viviana R.

    2013-07-17

    The basic principle of tissue engineering is the combination of appropriate cells with biomaterials under conditions that promote and lead to tissue formation. A tissue engineering scaffold is a material that supports cells for their growth...

  11. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    dental applications, including bioactive glasses, ceramics, and composites [10]. Resorbable biomaterials (

  12. Development of Controlled Matrix Heterogeneity on a Triphasic Scaffold for Orthopedic Interface Tissue Engineering

    E-Print Network [OSTI]

    Lu, Helen H.

    reconstruction because of the high incidence of donor site morbidity associated with bone-patellar 1 Biomaterials Department of Orthopaedic Surgery, Columbia University, New York, New York. 4 College of Dental Medicine

  13. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01

    nanostructured cubic zirconia. arXiv.org, 13. Biggs, M.J. ,et al. , Bioactivity of zirconia nanotube arrays fabricatedcrosslinked UHMWPE and zirconia implants in knee simulation.

  14. Quantitative determination of proximal radial and ulnar growth rates in foals using orthopedic markers 

    E-Print Network [OSTI]

    Smith, Barbara Lynn

    1988-01-01

    and ulna. Horse 6 both limbs 29 10 Cumulative growth of proximal radius and ulna. All horses all limbs 31 FIGURE page Cumulative growth of proximal radius and ulna. All horses left limbs 34 12 Cumulative growth of proximal radius and ulna. All horses... 27 Cumulati ve growth of radius and ulna at epiphyseal and meta- physeal levels. All horses left limbs 70 28 Cumulative growth between radius and ulna at epiphyseal and meta- physeal levels. All horses right limbs 72 29 Immediate postop...

  15. Improved performance of ultra-high molecular weight polyethylene for orthopedic applications 

    E-Print Network [OSTI]

    Plumlee, Kevin Grant

    2009-05-15

    taken in a JOEL-6400 scanning electron microscope (SEM), and were prepared using a ruthenium vapor coating method [28], then lightly sputter-coated with gold-palladium. Sections of impact samples were cut with razor blades, and then imaged in both.... Samples were prepared for imaging first with a ruthenium vapor coating 29 technique [28], then with a light sputter coating of gold-palladium. The ruthenium vapor coating creates a more even coating on highly mottled surfaces than sputter coating would...

  16. Holdover inoculum of Pseudomonas syringae pv. alisalensis from broccoli raab causes disease in subsequent plantings

    E-Print Network [OSTI]

    Cintas, N A; Koike, S T; Bunch, R A; Bull, C T

    2006-01-01

    alisalensis from Broccoli Raab Causes Disease in Subsequentalisalensis from broccoli raab causes disease in subsequentsyringae pv. maculicola causes bacterial spot on many

  17. Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health

    E-Print Network [OSTI]

    Tartof, Sara Yee

    2010-01-01

    rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

  18. Is coronary heart disease rising in India? A systematic review based on ECG defined coronary heart disease 

    E-Print Network [OSTI]

    Ahmad, N; Bhopal, Raj

    2005-01-01

    The aim of this study was to investigate whether coronary heart disease (CHD) is rising in India and assess the quality of the evidence. Thirty one studies were reviewed. The sample sizes of the studies varied from ...

  19. New insights into the natural history of thrombo-embolic disease provided by imaging and disease quantification 

    E-Print Network [OSTI]

    Murchison, John Tallach

    2013-07-06

    Venous thromboembolism (VTE) is a common disease with a myriad of presentation. It is often difficult to diagnosis with symptoms which are shared with many other disorders. Because of the overlap in symptomatology with ...

  20. Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases

    E-Print Network [OSTI]

    Jackson, Walker S.

    In man, mutations in different regions of the prion protein (PrP) are associated with infectious neurodegenerative diseases that have remarkably different clinical signs and neuropathological lesions. To explore the roots ...

  1. Associations of indoor carbon dioxide concentrations, VOCS, environmental susceptibilities with mucous membrane and lower respiratory sick building syndrome symptoms in the BASE study: Analyses of the 100 building dataset

    SciTech Connect (OSTI)

    Apte, M.G.; Erdmann, C.A.

    2002-10-01

    Using the 100 office-building Building Assessment Survey and Evaluation (BASE) Study dataset, we performed multivariate logistic regression analyses to quantify the associations between indoor minus outdoor CO{sub 2} (dCO{sub 2}) concentrations and mucous membrane (MM) and lower respiratory system (Lresp) Sick Building Syndrome (SBS) symptoms, adjusting for age, sex, smoking status, presence of carpet in workspace, thermal exposure, relative humidity, and a marker for entrained automobile exhaust. Using principal components analysis we identified a number of possible sources of 73 measured volatile organic compounds in the office buildings, and assessed the impact of these VOCs on the probability of presenting the SBS symptoms. Additionally we included analysis adjusting for the risks for predisposition of having SBS symptoms associated with the allergic, asthmatic, and environmentally sensitive subpopulations within the office buildings. Adjusted odds ratios (ORs) for statistically significant, dose-dependant associations (p<0.05) for dry eyes, sore throat, nose/sinus congestion, and wheeze symptoms with 100-ppm increases in dCO{sub 2} ranged from 1.1 to 1.2. These results suggest that increases in the ventilation rates per person among typical office buildings will, on average significantly reduce the prevalence of several SBS symptoms, up to 80%, even when these buildings meet the existing ASHRAE ventilation standards for office buildings. VOC sources were observed to play an role in direct association with mucous membrane and lower respiratory irritation, and possibly to be indirectly involved in indoor chemical reactions with ozone that produce irritating compounds associated with SBS symptoms. O-xylene, possibly emitted from furniture coatings was associated with shortness of breath (OR at the maximum concentration = 8, p < 0.05). The environmental sensitivities of a large subset of the office building population add to the overall risk of SBS symptoms (ORs ranging from 2 to above 11) within the buildings.

  2. Integrative Analysis of Common Neurodegenerative Diseases Using Gene Association, Interaction Networks and mRNA Expression Data

    E-Print Network [OSTI]

    Koyuturk, Mehmet

    , Inc., Cleveland OH. * Corresponding author Abstract Alzheimer's and Parkinson's diseases (AD and PD Alzheimer's disease (AD) and Parkinson's disease (PD) are caused by progressive degeneration and/or deathIntegrative Analysis of Common Neurodegenerative Diseases Using Gene Association, Interaction

  3. Airborne spread of foot-and-mouth disease - model intercomparison

    SciTech Connect (OSTI)

    Gloster, J; Jones, A; Redington, A; Burgin, L; Sorensen, J H; Turner, R; Dillon, M; Hullinger, P; Simpson, M; Astrup, P; Garner, G; Stewart, P; D'Amours, R; Sellers, R; Paton, D

    2008-09-04

    Foot-and-mouth disease is a highly infectious vesicular disease of cloven-hoofed animals caused by foot-and-mouth disease virus. It spreads by direct contact between animals, by animal products (milk, meat and semen), by mechanical transfer on people or fomites and by the airborne route - with the relative importance of each mechanism depending on the particular outbreak characteristics. Over the years a number of workers have developed or adapted atmospheric dispersion models to assess the risk of foot-and-mouth disease virus spread through the air. Six of these models were compared at a workshop hosted by the Institute for Animal Health/Met Office during 2008. A number of key issues emerged from the workshop and subsequent modelling work: (1) in general all of the models predicted similar directions for 'at risk' livestock with much of the remaining differences strongly related to differences in the meteorological data used; (2) determination of an accurate sequence of events is highly important, especially if the meteorological conditions vary substantially during the virus emission period; and (3) differences in assumptions made about virus release, environmental fate, and subsequent infection can substantially modify the size and location of the downwind risk area. Close relationships have now been established between participants, which in the event of an outbreak of disease could be readily activated to supply advice or modelling support.

  4. Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function*

    E-Print Network [OSTI]

    Li, Lian

    Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function by which loss-of-function mutations in DJ-1 lead to Par- kinson's disease. Parkinson's disease (PD)1 of this devastating disease. Recent evidence indi- cates that at least 10 distinct genetic loci, PARK1­PARK10

  5. Available online at www.sciencedirect.com A cellular perspective on conformational disease: the role of

    E-Print Network [OSTI]

    Morimoto, Richard

    of destabilized proteins. Genetic mutations in conformational disease-associated proteins, as well as exposure in the genetic background may account for some of the cell-type specificity observed in disease, even when neurodegenerative diseases, including Alzheimer's Dis- ease (AD), Parkinson's Disease (PD), Amyotrophic Lat- eral

  6. Clues to How Alpha-Synuclein Damages Neurons in Parkinson's Disease

    E-Print Network [OSTI]

    Sulzer, David

    -synuclein; Parkinson's disease a-SYN AS A CAUSE OF PARKINSON'S DISEASE Multiple genetic mutations can cause ParkinsonClues to How Alpha-Synuclein Damages Neurons in Parkinson's Disease David Sulzer, PhD* Departments vesicles. The pathogenic effects of a-syn leading to Parkin- son's disease (PD) appear to result from

  7. Exploring candidate genes for human brain diseases from a brain-specific gene network

    E-Print Network [OSTI]

    Jiang,Tianzi

    identifying multiple candidate genes for genetic human brain diseases from a brain-specific gene network; Candidate genes Many common human brain diseases, such as schizo- phrenia, Alzheimer's disease, Parkinson's disease, depres- sion, etc., have prominent genetic components [1,2]. Most researchers think that large

  8. Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases*

    E-Print Network [OSTI]

    Li, Lian

    Oxidative Damage of DJ-1 Is Linked to Sporadic Parkinson and Alzheimer Diseases* Received an autosomal recessive, early onset familial form of Parkinson disease (PD). However, little is presently known with sporadic PD and AD. Alzheimer disease (AD)2 and Parkinson disease (PD) are the two most common

  9. South Carolina Pest Management Handbook for Field Crops -2015 TOBACCO DISEASE MANAGEMENT

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 293 TOBACCO DISEASE MANAGEMENT Bruce and potentially devastating diseases of tobacco can best be managed through a combination of control methods. It is urged that growers identify disease problems in their fields and follow disease management suggestions

  10. Estimating Seasonal Drivers in Childhood Infectious Diseases with Continuous Time Models 

    E-Print Network [OSTI]

    Abbott, George H.

    2010-07-14

    similar results for a relatively unstudied city in childhood infectious disease research, Bangkok, Thailand....

  11. Remote sensing, global warming, and vector-borne disease

    SciTech Connect (OSTI)

    Wood, B.; Beck, L.; Dister, S.; Lobitz, B.

    1997-12-31

    The relationship between climate change and the pattern of vector-borne disease can be viewed at a variety of spatial and temporal scales. At one extreme are changes such as global warming, which are continental in scale and occur over periods of years, decades, or longer. At the opposite extreme are changes associated with severe weather events, which can occur at local and regional scales over periods of days, weeks, or months. Key ecological factors affecting the distribution of vector-borne diseases include temperature, precipitation, and habitat availability, and their impact on vectors, pathogens, reservoirs, and hosts. Global warming can potentially alter these factors, thereby affecting the spatial and temporal patterns of disease.

  12. Using dimension reduction to improve outbreak predictability of multistrain diseases

    E-Print Network [OSTI]

    Leah B. Shaw; Lora Billings; Ira B. Schwartz

    2006-07-12

    Multistrain diseases have multiple distinct coexisting serotypes (strains). For some diseases, such as dengue fever, the serotypes interact by antibody-dependent enhancement (ADE), in which infection with a single serotype is asymptomatic, but contact with a second serotype leads to higher viral load and greater infectivity. We present and analyze a dynamic compartmental model for multiple serotypes exhibiting ADE. Using center manifold techniques, we show how the dynamics rapidly collapses to a lower dimensional system. Using the constructed reduced model, we can explain previously observed synchrony between certain classes of primary and secondary infectives (Schwartz et al., Phys. Rev. E 72: 066201, 2005). Additionally, we show numerically that the center manifold equations apply even to noisy systems. Both deterministic and stochastic versions of the model enable prediction of asymptomatic individuals that are difficult to track during an epidemic. We also show how this technique may be applicable to other multistrain disease models, such as those with cross-immunity.

  13. Investigation of saliva of patients with periodontal disease using NAA

    SciTech Connect (OSTI)

    Zamboni, C. B.; Metairon, S.; Medeiros, I. M. M. A.

    2013-05-06

    In this study the non-stimulated whole saliva of 26 healthy subjects (mean age 33.9 {+-} 11.0 years, range: 26 to 49 years) and 11 patients with periodontal disease (mean age 41.7 {+-} 11.5 years; range 29 to 55 years) was investigated using Neutron Activation Analysis (NAA) technique. The samples were obtained from donors at Sao Paulo city (Brazil). The analyses were performed in the nuclear reactor IEA-R1 (3.5-4.5MW, pool type) at IPEN/CNEN-SP (Brazil). Considerable changes in Ca and S saliva's level were identified in patients with periodontal disease suggesting they can be used as monitors of periodontal diseases.

  14. Complications of treatment of Hodgkin's disease in children

    SciTech Connect (OSTI)

    Donaldson, S.S.; Kaplan, H.S.

    1982-04-01

    An analysis of complications of therapy requires long-term and frequent followup. Reported here is a review of 179 consecutive children with Hodgkin's disease from Stanford University Medical Center who were seen, treated, and followed over a 20-year period. Complications of treatment are related to the extent of disease and the aggressiveness of therapy. Severe complications from radiotherapy are associated with high-dose, extended-field treatment in preadolescent children. Severe chemotherapy-associated complications include immunosuppression, sterility, and secondary oncogenesis. As cure rates are increasingly optimistic among children with Hodgkin's disease, successful treatment with minimal morbidity remains our greatest challenge. Therapy programs require continual refinement utilizing assessment of short- and long-term side effects of treatment.

  15. Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xia, Jing; Rocke, David M.; Perry, George; Ray, Monika

    2014-01-01

    In late-onset Alzheimer’s disease (AD), multiple brain regions are not affected simultaneously. Comparing the gene expression of the affected regions to identify the differences in the biological processes perturbed can lead to greater insight into AD pathogenesis and early characteristics. We identified differentially expressed (DE) genes from single cell microarray data of four AD affected brain regions: entorhinal cortex (EC), hippocampus (HIP), posterior cingulate cortex (PCC), and middle temporal gyrus (MTG). We organized the DE genes in the four brain regions into region-specific gene coexpression networks. Differential neighborhood analyses in the coexpression networks were performed to identify genes with lowmore »topological overlap (TO) of their direct neighbors. The low TO genes were used to characterize the biological differences between two regions. Our analyses show that increased oxidative stress, along with alterations in lipid metabolism in neurons, may be some of the very early events occurring in AD pathology. Cellular defense mechanisms try to intervene but fail, finally resulting in AD pathology as the disease progresses. Furthermore, disease annotation of the low TO genes in two independent protein interaction networks has resulted in association between cancer, diabetes, renal diseases, and cardiovascular diseases.« less

  16. Compositions and Methods for the Treatment of Pierce's Disease

    DOE Patents [OSTI]

    Gupta, Goutam (Santa Fe, NM)

    2008-10-07

    Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

  17. Neurobiology of Disease Cortical Folding Abnormalities in Autism Revealed by

    E-Print Network [OSTI]

    Van Essen, David

    Neurobiology of Disease Cortical Folding Abnormalities in Autism Revealed by Surface-based morphometry across a range of autism spectrum disorders (7.5­18 years of age). We generated sulcal depth maps autism spectrum disorder subgroups: low-functioning autism, high-functioning autism, and Asperger

  18. Disease Risks Associated with Importation of Nonindigenous Marine Animals

    E-Print Network [OSTI]

    at the Nonindigenous Marine Species Plan ning Mt;eting of the National Research Council, Washington, D.C., 7 May 1991 directed to the third-disease and its implications in introductions. This is entirely logical, since infections that may cause stunting (Kalagayan et aI., 1991). Experimental infections with IHHNV have been

  19. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    ) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 disease (AD). Methods: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State

  20. Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease

    E-Print Network [OSTI]

    Levenson, Robert W.

    Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease Madeleine instructed and spontaneous emotion regulation in patients with frontotemporal lobar degeneration (FTLD, N 32) unwarned without instructions to down-regulate, (b) warned without instructions to down-regulate, and (c

  1. Azasugar inhibitors as pharmacological chaperones for Krabbe disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hill, Chris H.; Viuff, Agnete H.; Spratley, Samantha J.; Salamone, Stéphane; Christensen, Stig H.; Read, Randy J.; Moriarty, Nigel W.; Jensen, Henrik H.; Deane, Janet E.

    2015-03-23

    Krabbe disease is a devastating neurodegenerative disorder characterized by rapid demyelination of nerve fibers. This disease is caused by defects in the lysosomal enzyme ?-galactocerebrosidase (GALC), which hydrolyzes the terminal galactose from glycosphingolipids. These lipids are essential components of eukaryotic cell membranes: substrates of GALC include galactocerebroside, the primary lipid component of myelin, and psychosine, a cytotoxic metabolite. Mutations of GALC that cause misfolding of the protein may be responsive to pharmacological chaperone therapy (PCT), whereby small molecules are used to stabilize these mutant proteins, thus correcting trafficking defects and increasing residual catabolic activity in cells. Here we describe amore »new approach for the synthesis of galacto-configured azasugars and the characterization of their interaction with GALC using biophysical, biochemical and crystallographic methods. We identify that the global stabilization of GALC conferred by azasugar derivatives, measured by fluorescence-based thermal shift assays, is directly related to their binding affinity, measured by enzyme inhibition. X-ray crystal structures of these molecules bound in the GALC active site reveal which residues participate in stabilizing interactions, show how potency is achieved and illustrate the penalties of aza/iminosugar ring distortion. The structure–activity relationships described here identify the key physical properties required of pharmacological chaperones for Krabbe disease and highlight the potential of azasugars as stabilizing agents for future enzyme replacement therapies. This work lays the foundation for new drug-based treatments of Krabbe disease.« less

  2. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    CME Motor signs predict poor outcomes in Alzheimer disease N. Scarmeas, MD; M. Albert, PhD; J--Objective: To examine whether the presence of motor signs has predictive value for important outcomes in Alzheimer months for a total of 3,149 visit-assessments, average 5.9 per patient), the presence of motor signs

  3. Transmission mode and disease thresholds in host communities Janis Antonovics,

    E-Print Network [OSTI]

    Antonovics, Janis

    1 Transmission mode and disease thresholds in host communities Janis Antonovics, Department of Biology, University of Virginia, VA 22904, USA E-mail: ja8n@virginia.edu Running title Transmission mode transmission have close analogies with thresholds for species persistence when there is competition

  4. Polymorphism in sexual versus non-sexual disease transmission

    E-Print Network [OSTI]

    Antonovics, Janis

    Polymorphism in sexual versus non-sexual disease transmission PETER H. THRALL AND JANIS ANTONOVICS conditions under which a genetic variant with one (e.g. sexual) transmission mode can invade and successfully displace a genetic variant with a different (e.g. non-sexual) transmission mode. Invasion by an STD

  5. GUANYLATE CYCLASE-ACTIVATING PROTEINS AND RETINA DISEASE

    E-Print Network [OSTI]

    Palczewski, Krzysztof

    of the rod cell contains high levels of cGMP (1­10 M) maintaining a number of CNG channels in an open state. Within milliseconds after a light flash, cGMP-gated (CNG) cation channels close and photoreceptor cells hyperpolarize. Open CNG 71 E. Carafoli and M. Brini (eds.), Calcium Signalling and Disease, 71­91. © 2007

  6. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan.....................................................................................................................................2 3.1. IDPs are tightly regulated from transcript synthesis to protein degradation ......................................................................................................................................8 #12;1 Abstract Intrinsically disordered proteins (IDPs) are often enriched in signaling

  7. September/October 2000 New Disease Booklet Web Marketing

    E-Print Network [OSTI]

    Ishida, Yuko

    the Restrictions Strawberry Pollination CSBA Convention Schedule Honey Quality CA Organic Farming New Disease is the APHIS Publication Distribution Center. Strawberry Pollination We don't often look at state or provincial, of Manitoba Agriculture, devised experiments to determine the effect of insect pollination on a strawberry

  8. Bayesian approach to transforming public gene expression repositories into disease

    E-Print Network [OSTI]

    Zhou, Xianghong Jasmine

    expression data and heterogeneous disease annota- tions, allows analyzing both sources of information concepts. This effort requires the effective integration of the two major information sources in the GEO of Southern California, Los Angeles, CA 90089; and c Institute of Genomics and Bioinformatics, National Chung

  9. PUBLICATION 600-080 Fish Health and Disease

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

  10. Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 to alternation in the functional brain network, i.e., the functional connectivity among different brain regions. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

  11. Mathematical models and the fight against diseases in Africa

    E-Print Network [OSTI]

    Getz, Wayne M.

    Mathematical models and the fight against diseases in Africa Wayne M.Getz a* ,Eleanor Gouws b theories. While South Africa has many talented scientists trained in quantitative methods, relatively few infrastructural investment is needed to address the health crises in Africa. Prior to the advent of HIV

  12. Diseases of plantation forestry trees in eastern and southern Africa

    E-Print Network [OSTI]

    Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B a Introduction Plantations of non-native trees have been grown in Africa for more than 100 years.1,2 The most especially for construction timber and fuel, while in southern Africa this timber also sustains a thriving

  13. Virus Specificity in Disease Systems: Are Species Redundant?

    E-Print Network [OSTI]

    Flecker, Alex

    Chapter 17 m Virus Specificity in Disease Systems: Are Species Redundant? Alison G. Power about the effects of plant viruses despite their ubiquitous distribution in plants. Several recent studies have stressed the prevalence of viruses in natural plant populations (e.g., Power and Remold 1996

  14. 2006 International Centre for Diarrhoeal Disease Research, Bangladesh

    E-Print Network [OSTI]

    California at Berkeley, University of

    © 2006 International Centre for Diarrhoeal Disease Research, Bangladesh J HEALTH POPUL NUTR 2006, including Inner Mongolia, Thailand, Cambodia, and Bangladesh (2-4). In all these regions, the main source suggests the presence of arsenic in ground- water in India and Bangladesh throughout the region defined

  15. Random Disease on the Square Grid J ozsef Balogh

    E-Print Network [OSTI]

    Balogh, Jozsef

    a disease process. The initial configuration is called contagious or successful if the corresponding) squares in a contagious configuration. The solution of the initial exercise is the following: Fact. [Folklore] G(n) = n. Proof. If we paint the squares of a diagonal black, it will be a contagious

  16. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  17. Prediction and Informative Risk Factor Selection of Bone Diseases

    E-Print Network [OSTI]

    Buffalo, State University of New York

    --Electronic health records (EHRs); risk factor analysis; integrated feature extraction; risk factor selection1 Prediction and Informative Risk Factor Selection of Bone Diseases Hui Li, Xiaoyi Li, Murali and the overwhelming amount of electronic health records (EHRs) shared by healthcare institutions and practitioners, we

  18. A Network-Based Approach to Understanding and Predicting Diseases

    E-Print Network [OSTI]

    Chawla, Nitesh V.

    and emergent behavior over time. Our analysis reveals important insights with implications for modeling increases in cost of health care for the United States. Contributions: The aforementioned issues model to assess disease risk for individuals based on medical history. We evaluate the ability of our

  19. AT A GLANCE....INSECTS AND DISEASE PROBLEMS THAT SHOULD BE CONSIDERED THIS PEST/DISEASE/CULTURE

    E-Print Network [OSTI]

    Goodman, Robert M.

    /DISEASE/CULTURE JULY 8- JULY 15 HARVEST JULY 15- JULY 22 HARVEST SPOTTED WING DROSOPHILA Lannate, Imidan, Malathion effective against aphids and maggot when possible. Monitor with traps, and use materials that are also effective against aphids and maggot when possible. BLUEBERRY MAGGOT See list from previous newsletter

  20. Unusual thoracic radiographic findings in children treated for Hodgkin's disease

    SciTech Connect (OSTI)

    Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

    1986-06-01

    Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

  1. Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease

    E-Print Network [OSTI]

    Galvin, James E.; Malcom, Heather; Johnson, David Kevin; Morris, John C.

    2007-05-29

    Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease James E. Galvin, MD, MPH Heather Malcom David Johnson, PhD John C. Morris, MD ABSTRACT Objective: To identify personality traits that distinguish dementia with Lewy... and differentiation in conjunction with other DLB features. METHODS Research participants. Beginning in 1979, over 3,000 individuals have been enrolled in our longitudinal studies of healthy aging and dementia and over 800 of these participants have been studied...

  2. Travel and migration associated infectious diseases morbidity in Europe, 2008

    E-Print Network [OSTI]

    Field, Vanessa; Gautret, Philippe; Schlagenhauf, Patricia; Burchard, Gerd-Dieter; Caumes, Eric; Jensenius, Mogens; Castelli, Francesco; Gkrania-Klotsas, Effrossyni; Weld, Leisa; Lopez-Velez, Rogelio; de Vries, Peter; von Sonnenburg, Frank; Loutan, Louis; Parola, Philippe; Network, the EuroTravNet

    2010-11-17

    to adjust for the large number of statistical tests performed. Ethics approval The GeoSentinel International data-collection protocol used by EuroTravNet was reviewed by the institutional review board officer at the National Center for Infec- tious Diseases... on a return visit to his country of birth Algeria; three cases of toxo- plasmosis, 20 cases of acute Epstein Barr Virus infection, and one case of histoplasmosis. Bacterial infections accounted for most dermatological diagnoses followed by arthropod...

  3. Storage and Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Youngblood, B. (Bonney)

    1919-01-01

    STATION AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS W. B. BIZZELL, President BULLETIN TuO. 250 OCTOBER, 1919 EXPERIMENT STATION AND EXTENSION SERVICE COOPERATING STORAGE AND DISEASES OF THE SWEET POTATO IN TEXAS B. YOUNGBLOOD, DIRECTOR College... cooperation with the United States Department of Agriculture. FOREWORD. Sweet potato storage is a comparatively new industry in Texas. Dur- ing the past few years, hoaeyer, a great deal of interest has been mani- fested in improved methods of storage...

  4. A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

    E-Print Network [OSTI]

    Pagliarini, David J.

    James G. Evans,8 David R. Thorburn,5,6 Steven A. Carr,3,* and Vamsi K. Mootha1,2,3,* 1Center for HumanA Mitochondrial Protein Compendium Elucidates Complex I Disease Biology David J. Pagliarini,1 A. Walford,1,2 Canny Sugiana,5 Avihu Boneh,5,6 William K. Chen,1,2 David E. Hill,7 Marc Vidal,7

  5. Pathogenesis of human papillomavirus-associated mucosal disease

    E-Print Network [OSTI]

    Groves, Ian J.; Coleman, Nicholas

    2014-12-08

    =UTF-8 For Peer Review Pathogenesis of human papillomavirus-associated mucosal disease. Journal: The Journal of Pathology Manuscript ID: Draft Wiley - Manuscript type: Invited Review Date Submitted by the Author: n/a Complete... advantage. Selection of integrated HRHPV occurs relatively early in cervical carcinogenesis and determinants of selection have been difficult to investigate adequately using clinical samples [36]. However, the W12 model of HPV16-associated cervical...

  6. Using Genomics to Study Human Biology and Disease

    SciTech Connect (OSTI)

    Myers, Ricard M.

    2005-04-06

    The Human Genome Project culminated in April 2003 with the finished DNA sequence of all of the human chromosomes. This book of information, particularly in conjunction with the genome sequences of many other organisms, has already begun to revolutionize the way that biomedical scientists study our species. The identification of essentially all of our genes has provided a template upon which researchers can discover basic processes that govern cells, organs, and the whole organism, and to understand the fundamental causes of the diseases that occur when something goes wrong with a gene or a set of genes. The Genome Project has already made it possible to identify the genes that are defective in more than 1,000 rare inherited diseases, and these discoveries have helped to understand the mechanisms of the more common forms of these disorders. This understanding of primary defects in diseases - which is translated as mutations in genes that encode proteins that serve specific functions - is transforming the way that biotechnology and pharmaceutical companies identify drug targets, and a few notable cases have already had a striking impact on specific diseases. In addition, it has become clear that the differential response to drugs in human populations is heavily influenced by genes, and a whole field called pharmacogenetics has begun to identify these genetic factors. Such knowledge will allow physicians to prescribe drugs targeted to each individual, with the potential to increase efficacy and decrease side-effects. Determining the DNA sequence of the human genome and identifying the genes has been an exciting endeavor, but we are only just beginning to understand the treasures present in all of our DNA. My presentation will briefly describe the road we took to get the sequence, as well as the tools that we are developing to unlock its secrets.

  7. Selection of a multiple disease resistant runner-type peanut 

    E-Print Network [OSTI]

    Baring, Michael Robert

    2007-09-17

    SELECTION OF A MULTIPLE DISEASE RESISTANT RUNNER-TYPE PEANUT A Thesis by MICHAEL ROBERT BARING Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, William Rooney Committee Members, Charles Simpson James Starr Robert Lemon Head of Department, C.W. Smith May 2006 Major Subject: Plant...

  8. Disease-induced resource constraints can trigger explosive epidemics

    E-Print Network [OSTI]

    Böttcher, Lucas; Araújo, Nuno A M; Herrmann, Hans J; Helbing, Dirk

    2015-01-01

    Advances in mathematical epidemiology have led to a better understanding of the risks posed by epidemic spreading and informed strategies to contain disease spread. However, a challenge that has been overlooked is that, as a disease becomes more prevalent, it can limit the availability of the capital needed to effectively treat those who have fallen ill. Here we use a simple mathematical model to gain insight into the dynamics of an epidemic when the recovery of sick individuals depends on the availability of healing resources that are generated by the healthy population. We find that epidemics spiral out of control into "explosive" spread if the cost of recovery is above a critical cost. This can occur even when the disease would die out without the resource constraint. The onset of explosive epidemics is very sudden, exhibiting a discontinuous transition under very general assumptions. We find analytical expressions for the critical cost and the size of the explosive jump in infection levels in terms of the...

  9. Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk

    E-Print Network [OSTI]

    Koenig, Gerald

    2015-01-01

    Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT’s predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a ...

  10. Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

    E-Print Network [OSTI]

    Young, Carissa L.

    Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across ...

  11. Precision medicine in chronic disease management: The multiple sclerosis BioScreen

    E-Print Network [OSTI]

    2014-01-01

    Disease Management: The Multiple Sclerosis BioScreen Pierre-unpredictable disease like multiple sclerosis? Eur J NeurolHL. The challenge of multiple sclerosis: how do we cure a

  12. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk

    E-Print Network [OSTI]

    Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus). Subsequently, the disease was diagnosed in black-tailed deer, Rocky Mountain elk (Williams & Young, 1982, 1992

  13. Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg. 

    E-Print Network [OSTI]

    Stephens LA; Malpass KH; Anderton SM

    2009-01-01

    The potential use of CD4(+)Foxp3(+) Treg as a cellular therapy for autoimmune disease is of great interest. For clinical translation, the key objective is to reverse established disease. Here we demonstrate that myelin ...

  14. Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease 

    E-Print Network [OSTI]

    Tzoulaki, Ioanna

    2007-01-01

    Peripheral arterial disease (PAD) defines atherosclerotic disease of the arteries to the legs. PAD begins early in life and remains asymptomatic over long periods. The ankle brachial index (ABI) is an important diagnostic ...

  15. Morphological, cellular and proteomic features of canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Han, Richard I-Ming

    2009-01-01

    Myxomatous mitral valve degeneration (MMVD) is the single most common cardiac disease of the dog, and is analogous to Mitral Valve Prolapse in humans. Very little is known about the aetiopathogenesis of this disease or ...

  16. Economic Consequences Associated with Johne’s Disease in Cow-Calf Operations 

    E-Print Network [OSTI]

    Bhattarai, Bikash

    2013-08-05

    Johne’s disease (JD) in cattle is a disease of economic importance caused by Mycobacterium avium subspecies paratuberculosis (MAP). Studies were conducted to estimate the losses due to lower weaning weight of beef calves ...

  17. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Snihs, "The Significance of Radon and Its Progeny as NaturalDivision Human Disease from Radon Exposures: The I P ImpactVent 78-5 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF

  18. v-abl causes hematopoietic disease distinct from that caused by bcr-abl.

    E-Print Network [OSTI]

    Scott, M L; Van Etten, R A; Daley, G Q; Baltimore, D

    1991-01-01

    Medical Sciences v-abl causes hematopoietic disease distinctcells. bcr-abl also causes a CML-like syndrome in mice whosevirus-containing sys- tem, causes disease similar to, but

  19. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration.

    E-Print Network [OSTI]

    2007-01-01

    in Alzheimer’s disease causes neuronal death. FASEB J. 2001;Manuscript Figure 1. UbB + 1 causes neuritic beading andfound in Alzheimer’s disease causes neuritic beading of

  20. Structural Findings in the Basal Ganglia in Genetically Determined and Idiopathic Parkinson's Disease

    E-Print Network [OSTI]

    Gaser, Christian

    Structural Findings in the Basal Ganglia in Genetically Determined and Idiopathic Parkinson likely have an increased risk to develop Parkinson's disease (PD). We hypothesized BG morphological Key words: basal ganglia; magnetic resonance imaging; Parkinson's disease; Parkin mutation carriers

  1. Immunization with a Borrelia burgdorferi BB0172-Derived Peptide Protects Mice against Lyme Disease 

    E-Print Network [OSTI]

    Small, Christina M.; Ajithdoss, Dharani K.; Hoffmann, Aline Rodrigues; Mwangi, Waithaka; Esteve-Gassent, Maria D.

    2014-02-05

    Lyme disease is the most prevalent arthropod borne disease in the US and it is caused by the bacterial spirochete Borrelia burgdorferi (Bb), which is acquired through the bite of an infected Ixodes tick. Vaccine development efforts focused...

  2. The development of new tools for field and laboratory diagnosis of Pierces Disease 

    E-Print Network [OSTI]

    Bryan, Kelly Asbill

    2009-05-15

    Pierce’s Disease (PD), caused by Xylella fastidiosa, is a devastating bacterial disease of grapevines. One of the few control options is roguing. Roguing depends on precise diagnosis of PD in vines. These experiments were conducted to improve...

  3. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women 

    E-Print Network [OSTI]

    Ghahramany, Ghazal

    2012-07-16

    About half of all deaths in developed countries are caused by cardiovascular disease. It is well known that cardiovascular disease (CVD) risk can be influenced by diet, but optimal dietary content of fatty acids continues ...

  4. Di#erential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    , Dublin City University, Dublin 9, Ireland Abstract Aujeszky's Disease virus, (ADV) is a contagious viral Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  5. Micro-Simulations of Infectious Disease using Official Register Data The Case of Smallpox

    E-Print Network [OSTI]

    Boman, Magnus

    , for example. #12;Introduction Should an infection of a contagious disease occur, the potential threat must be seen as an example of a predominantly airborne, fairly contagious vaccine-preventable disease where

  6. Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

    E-Print Network [OSTI]

    Thompson, Paul

    Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

  7. Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson’s Disease from Traditional Chinese Medicine

    E-Print Network [OSTI]

    Huang, Hung-Jin

    Dysfunction of ?-glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson’s disease occurrence. Pharmacological chaperone design has been used to ...

  8. CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

    E-Print Network [OSTI]

    Rezai-Zadeh, Kavon; Gate, David; Town, Terrence

    2009-01-01

    encephalitis . multiple sclerosis . experimental autoimmunedisease (AD), multiple sclerosis (MS), and Parkinson'sdemyelinating disease multiple sclerosis) and may also be

  9. Association Analysis of the Extended MHC Region in Celiac Disease Implicates Multiple Independent Susceptibility Loci

    E-Print Network [OSTI]

    2012-01-01

    Symposium on Coeliac Disease. Tampere, Finland: Institute ofTechnology, University of Tampere. pp 265–274. 25. Hall RP,

  10. "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2

    E-Print Network [OSTI]

    Watson, Craig A.

    VM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring on their fish. Typically, "red sore disease" is caused by two organisms, Aeromonas hydrophila , a bacterium

  11. Oxidative Modifications and Aggregation of Cu,Zn-Superoxide Dismutase Associated with Alzheimer and Parkinson Diseases*

    E-Print Network [OSTI]

    Li, Lian

    and Parkinson Diseases* Received for publication, December 20, 2004, and in revised form, January 18, 2005 oxidative stress has been strongly impli- cated in the pathogenesis of Alzheimer disease (AD) and Parkinson(s) that could potentially be tar- geted by similar therapeutic strategies. Alzheimer disease (AD),1 Parkinson

  12. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit

    E-Print Network [OSTI]

    Guo, Ming

    of Parkinson's disease. pink1 acts upstream of parkin in a common genetic pathway to regulate mitochondrialThe Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion represent a novel therapeutic strategy for Parkinson's disease. mitofusin drp1 opa1 parkin-pink1 Parkinson

  13. 8 THE AMERICAN SOCIETY FOR CELL BIOLOGY PRESS BOOK 2004 arkinson's disease (PD) was named

    E-Print Network [OSTI]

    Feng, Jian

    as a progressive neurodegenerative disease. Parkinson's is caused by the selective death of neurons that produce-radical-damaged tubulin. In this fight, mutated parkin apparently arrives unarmed. Parkinson's Disease: Shootout8 THE AMERICAN SOCIETY FOR CELL BIOLOGY PRESS BOOK 2004 P arkinson's disease (PD) was named

  14. Neurodegeneration and Neuroprotection in Parkinson Disease Stanley Fahn and David Sulzer

    E-Print Network [OSTI]

    Sulzer, David

    Neurodegeneration and Neuroprotection in Parkinson Disease Stanley Fahn and David Sulzer Department Parkinson disease (PD) result primarily from the loss of the neuromelanin (NM)-containing dopamine (DA, with at least one of them being tremor-at-rest or brady- kinesia. Parkinson disease (PD) is the major cause

  15. Parkinson's disease (PD) is characterized by the rela-tively selective degeneration of dopaminergic neurons in

    E-Print Network [OSTI]

    Feng, Jian

    Parkinson's disease (PD) is characterized by the rela- tively selective degeneration into a stiff, hollow tube. Each Microtubule: A Common Target for Parkin and Parkinson's Disease Toxins JIAN performed on twins (Tanner and others 1999), reveal strong environmental connections to the disease

  16. Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the

    E-Print Network [OSTI]

    Shorter, James

    Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the loss motor and cognitive problems. Although the disease was first described in 1817 (Parkinson, 2002), few treatments exist today. These treatments do not target the cause of the disease and instead aim to increase

  17. Neurobiology of Disease Functional Analysis of VPS41-Mediated Neuroprotection in

    E-Print Network [OSTI]

    Caldwell, Guy

    elegans and Mammalian Models of Parkinson's Disease Adam J. Harrington,1 Talene A. Yacoubian,2 Sunny R Disruptionofthelysosomalsystemhasemergedasakeycellularpathwayintheneurotoxicityof -synuclein( -syn)andtheprogression of Parkinson's disease (PD). A large-scale RNA interference for the treatment of synucleinopathies like PD. Introduction Parkinson's disease (PD) is the second most common

  18. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3

    E-Print Network [OSTI]

    Li, Lian

    Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase autosomal recessive forms of Parkinson disease (PD), but how these mutations trigger neurodegeneration pathway in the pathogenesis of PD. INTRODUCTION Parkinson disease (PD) is the most common neurodegenera

  19. Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis

    E-Print Network [OSTI]

    Abecasis, Goncalo

    ARTICLE Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis1,24,* Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically and enlarge the map of shared genetic risk loci. Introduction Psoriasis (PS [MIM 177900]) and Crohn disease

  20. Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease

    E-Print Network [OSTI]

    Carbonell, Jaime

    Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease Selen Uguroglu and Jaime Pittsburgh, PA 15212 Abstract We investigate machine learning methods for diagnos- tic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all

  1. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort

    E-Print Network [OSTI]

    van Geen, Alexander

    13 million residents in the United States.1 Although the International Agency for Research on Cancer Death from cardiovascular disease. Results 198 people died from diseases of circulatory system, accounting for 43% of total mortality in the population. The mortality rate for cardiovascular disease

  2. Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP)

    E-Print Network [OSTI]

    Charette, André

    Repurposing Drugs for Alzheimer's Disease and Related Dementias Request for Proposals (RFP) Neurodegenerative diseases represent one of the most difficult classes of diseases for which to develop drugs, yet, offering a huge opportunity to target some of these pathways with repurposed drugs approved

  3. The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease

    E-Print Network [OSTI]

    Jurewitz, Daniel L

    2007-01-01

    for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

  4. Glycosyl-phosphatidylinositol (GPI)-anchored membrane association of the porcine reproductive and respiratory syndrome virus GP4 glycoprotein and its co-localization with CD163 in lipid rafts

    SciTech Connect (OSTI)

    Du, Yijun [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States) [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan (China); Pattnaik, Asit K. [School of Veterinary Medicine and Biomedical Sciences and the Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900 (United States)] [School of Veterinary Medicine and Biomedical Sciences and the Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900 (United States); Song, Cheng [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States)] [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Yoo, Dongwan, E-mail: dyoo@illinois.edu [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States)] [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Li, Gang, E-mail: dyoo@illinois.edu [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States) [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Institute of Animal Science and Veterinary Medicine, Chinese Academy of Agricultural Sciences, Beijing (China)

    2012-03-01

    The porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 4 (GP4) resembles a typical type I membrane protein in its structure but lacks a hydrophilic tail at the C-terminus, suggesting that GP4 may be a lipid-anchored membrane protein. Using the human decay-accelerating factor (DAF; CD55), a known glycosyl-phosphatidylinositol (GPI) lipid-anchored protein, chimeric constructs were made to substitute the GPI-anchor domain of DAF with the putative lipid-anchor domain of GP4, and their membrane association and lipase cleavage were determined in cells. The DAF-GP4 fusion protein was transported to the plasma membrane and was cleaved by phosphatidylinositol-specific phospholipase C (PI-PLC), indicating that the C-terminal domain of GP4 functions as a GPI anchor. Mutational studies for residues adjacent to the GPI modification site and characterization of respective mutant viruses generated from infectious cDNA clones show that the ability of GP4 for membrane association corresponded to virus viability and growth characteristics. The residues T158 ({omega} - 2, where {omega} is the GPI moiety at E160), P159 ({omega} - 1), and M162 ({omega} + 2) of GP4 were determined to be important for virus replication, with M162 being of particular importance for virus infectivity. The complete removal of the peptide-anchor domain in GP4 resulted in a complete loss of virus infectivity. The depletion of cholesterol from the plasma membrane of cells reduced the virus production, suggesting a role of lipid rafts in PRRSV infection. Remarkably, GP4 was found to co-localize with CD163 in the lipid rafts on the plasma membrane. Since CD163 has been reported as a cellular receptor for PRRSV and GP4 has been shown to interact with this receptor, our data implicates an important role of lipid rafts during entry of the virus.

  5. Detection of bone disease in dogs by radioisotope scanning 

    E-Print Network [OSTI]

    Morris, Earl Louis

    1971-01-01

    in dogs for the diagnosis and progression of bone disease was studied. Twc isotopes of strontium, Sr and 85 87m Sr, were studied. The Sr was purchased 85 commercially and the Sr was produced at the 87m Texas A8cM University Nuclear Science Center... by the irradiation oi' Sr(N05)2. Criteria for bone scanning in dogs using Sr 85 and Sr were determined. Pour normal young dogs 87m were injected with Sr and four with Sr. Doses 85 87m of 100 p&i of Sr and 1 mCi of Sr were found . to 85 87m produoe satisfactory...

  6. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  7. Programming of cardiovascular disease across the life-course

    E-Print Network [OSTI]

    Blackmore, Heather L.; Ozanne, Susan E.

    2014-12-12

    ]. This increase in lifespan brings about a rise in age-associated conditions such as type 2 diabetes, cancer and cardiovascular disease (CVD). As CVD has a long pre-clinical phase resulting in diagnosis in old age, the identification of biomarkers that precede... F, Carter F, Walsh SW, Kenny DA, Smith GW, Ireland JL, et al. Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring. Biol Reprod. 2013;88:92. [33] Gilbert JS, Lang AL, Grant AR, Nijland MJ. Maternal nutrient...

  8. The Emergence of ActualThe Emergence of Actual Human Disease as a Model forHuman Disease as a Model for

    E-Print Network [OSTI]

    Boguski, Mark S.

    + Chromosomome +e + ""icsics"" == GenomicsGenomics 1990 Human Genome Project launched1990 Human Genome Project launched 1998 Human Genome Project1998 Human Genome Project acceleratedaccelerated 20002000 ""DraftThe Emergence of ActualThe Emergence of Actual Human Disease as a Model forHuman Disease as a Model

  9. Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Smoron, Geoffrey L.; Lennox, Arlene J.; Mcgee, James L.

    1999-01-01

    Purpose. To present a case study involving the use of fast neutron therapy to treat an extensive unresectable osteogenic sarcoma arising from the left maxilla. Patient. A 14-year-old male presented with a massive tumor producing severe distortion of his facial structures. He had already received six courses of chemotherapy, which had reduced his pain, but had not measurably reduced the tumor. Methods. The patient was treated with 66 MeV fast neutrons to a dose of 20.4 Gy in 13 fractions over 35 days. Results. CT assessments indicate gradually increasing calcification and noticeable reductionmore »of soft-tissue disease in the frontal sinus, orbit and maxillary antrum.There has been some recontouring of the facial structures.The boy conducts an active life, has no pain, and feels well. He was 17 years old at the last follow-up. Discussion. Fast neutrons have a greater biological effectiveness than conventional photon beams. Their use has been associated with improved chance for local control of unresectable disease.This case illustrates their effectiveness in controlling an unusual and aggressive osteogenic sarcoma of the facial bone and sinuses. « less

  10. Bead-based microfluidic immunoassay for diagnosis of Johne's disease

    SciTech Connect (OSTI)

    Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

    2012-01-01

    Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

  11. Winter Infections: Influenza, Respiratory Syncytial Virus (RSV)

    E-Print Network [OSTI]

    Goldman, Steven A.

    spread? Sick person can spread influenza by: ­ Touching ­ Sneezing ­ Coughing Picture: newbedfordguide Fever Cough Fatigue (feel "worn out") Headaches Body aches Runny nose #12;Influenza ("Flu") Treatments paralysis) #12;"MythBusters" Reported That: Sneezes can travel ~35 mph Cough/sneeze droplets can travel

  12. Respiratory Protection Program | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterestedReplacement-2-A Wholesale PowerNatural GasBreakout SessionsPOINT OF

  13. Hanford Site Respiratory Protection Program (HSRPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journalvivo Low-Dose Lowï‚—34OctoberK West60 Revision 1 Hanford0336

  14. Classification of interstitial lung disease patterns with topological texture features

    E-Print Network [OSTI]

    Huber, Markus B; Leinsinger, Gerda; Ray, Lawrence A; Wismüller, Axel; 10.1117/12.844318

    2010-01-01

    Topological texture features were compared in their ability to classify morphological patterns known as 'honeycombing' that are considered indicative for the presence of fibrotic interstitial lung diseases in high-resolution computed tomography (HRCT) images. For 14 patients with known occurrence of honey-combing, a stack of 70 axial, lung kernel reconstructed images were acquired from HRCT chest exams. A set of 241 regions of interest of both healthy and pathological (89) lung tissue were identified by an experienced radiologist. Texture features were extracted using six properties calculated from gray-level co-occurrence matrices (GLCM), Minkowski Dimensions (MDs), and three Minkowski Functionals (MFs, e.g. MF.euler). A k-nearest-neighbor (k-NN) classifier and a Multilayer Radial Basis Functions Network (RBFN) were optimized in a 10-fold cross-validation for each texture vector, and the classification accuracy was calculated on independent test sets as a quantitative measure of automated tissue characteriza...

  15. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  16. Why my disease is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003

    E-Print Network [OSTI]

    Gouda, Hebe N.; Powles, John W.

    2011-05-23

    stream_source_info 1478-7954-9-14.pdf.txt stream_content_type text/plain stream_size 20996 Content-Encoding UTF-8 stream_name 1478-7954-9-14.pdf.txt Content-Type text/plain; charset=UTF-8 RESEARCH Open Access Why my disease... is important: metrics of disease occurrence used in the introductory sections of papers in three leading general medical journals in 1993 and 2003 Hebe N Gouda* and John W Powles Abstract Background: We assessed the metrics used in claims about disease...

  17. Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification

    E-Print Network [OSTI]

    Tong, Lily Victoria

    2008-01-01

    Human societies face diverse health challenges including a rapidly aging population, rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes ...

  18. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  19. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  20. Integrated rotation systems for soilborne disease, weed and fertility management in strawberry/vegetable production

    E-Print Network [OSTI]

    2014-01-01

    dahliae infection rate of strawberry plants at the organicsoilborne diseases in strawberry using vegetable rotations.Fertility Management in Strawberry/Vegetable Production M.

  1. Possible common e,ological agent for strawberry disease and red mark syndrome in

    E-Print Network [OSTI]

    Kane, Andrew S.

    1 Possible common e,ological agent for strawberry disease and red mark Schering-Plough Animal Health, UK Possible common e,ological agent for strawberry

  2. Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

    E-Print Network [OSTI]

    2014-01-01

    Integrative Genomics Reveals Novel Molecular Pathways and7 | e1004502 Integrative Genomics of Coronary Artery Disease2012) Use of functional genomics to identify candidate genes

  3. On the multiscale modeling of heart valve biomechanics in health and disease

    E-Print Network [OSTI]

    Weinberg, Eli J.; Shahmirzadi, Danial; Mofrad, Mohammad Reza

    2010-01-01

    carried out on simulating biomechanics of mechan- ical andmodeling of heart valve biomechanics in health and diseasemodeling of heart valve biomechanics in health and disease

  4. Testing new dairy cattle for disease can boost herd health, cut costs

    E-Print Network [OSTI]

    Moore, Dale A; Adaska, J M; Higginbotham, G E; Castillo, Alejandro R Dr.; Collar, Carol; Sischo, William M

    2009-01-01

    Article t Testing new dairy cattle for disease can boosttest or exam- ine incoming cattle, although these importantin purchased groups of dairy cattle, in order to pro- vide

  5. Psoriasis in a 3-month-old infant with Kawasaki disease

    E-Print Network [OSTI]

    Liao, Yi-Chen; Lee, Julia Yu-Yun

    2009-01-01

    pincer nail deformity. Psoriasis or pityriasis lichenoides2 Figure 1. KD-associated psoriasis in the acute phase of KDFinkelstein Y. Guttate psoriasis following Kawasaki disease.

  6. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2013-01-01

    lower leg of a patient with psoriasis vulgaris. Acta Dermleg of a patient with psoriasis vulgaris.Acta Derm Venereol.Behcet's disease, psoriasis and hidradenitis suppurativa.

  7. A model for the coupled disease dynamics of HIV and HSV-2 with ...

    E-Print Network [OSTI]

    Christina Alvey

    2015-05-19

    May 4, 2015 ... We conclude that homosexual transmission drastically changes the disease prevalences; hence, it is important to account for this interaction as ...

  8. The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Groza, Tudor; Köhler, Sebastian; Moldenhauer, Dawid; Vasilevsky, Nicole; Baynam, Gareth; Zemojtel, Tomasz; Schriml, Lynn Marie; Kibbe, Warren Alden; Schofield, Paul N.; Beck, Tim; et al

    2015-06-25

    The Human Phenotype Ontology (HPO) is widely used in the rare disease community for differential diagnostics, phenotype-driven analysis of next-generation sequence-variation data, and translational research, but a comparable resource has not been available for common disease. Here, we have developed a concept-recognition procedure that analyzes the frequencies of HPO disease annotations as identified in over five million PubMed abstracts by employing an iterative procedure to optimize precision and recall of the identified terms. We derived disease models for 3,145 common human diseases comprising a total of 132,006 HPO annotations. The HPO now comprises over 250,000 phenotypic annotations for over 10,000more »rare and common diseases and can be used for examining the phenotypic overlap among common diseases that share risk alleles, as well as between Mendelian diseases and common diseases linked by genomic location. The annotations, as well as the HPO itself, are freely available.« less

  9. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2013-01-01

    any joint disease of the vertebral column. As such, it is ainvolvement of the vertebral column from any type of joint

  10. The role of phenoloxidase suppression in QX disease outbreaks among Sydney rock oysters

    E-Print Network [OSTI]

    Raftos, David

    disease. Oysters from the same brood stock were harvested from QX prone and QX free growing areas over negative correlation between phenoloxidase activity and the intensity of parasitic infection ( p = 0 prevented effective management of QX disease in endemic areas. Current management regimes rely only

  11. Proceedings of the 2nd workshop on lyme disease in the Southeast

    SciTech Connect (OSTI)

    Apperson, C.S. [ed.] [North Carolina State Univ., Raleigh, NC (United States). Dept. of Entomology; Levine, J.F. [ed.] [North Carolina State Univ., Raleigh, NC (United States). Dept. of Microbiology, Pathology, and Parasitology; Snoddy, E.L. [ed.] [Tennessee Valley Authority, Muscle Shoals, AL (United States)

    1993-12-31

    This volume provides author prepared abstracts of oral presentation at the Second Workshop on Lyme Disease in the Southeast head in Raleigh, North Carolina September 7-9, 1993. The 33 presentations covered various aspects of the epidemic including geographical distribution of various species of ticks, transmission risks, Lyme Disease epidemiology, and taxonomic aspects.

  12. GIS-Based Epidemiological Modeling of an Emerging Forest Disease: Spread of

    E-Print Network [OSTI]

    247 GIS-Based Epidemiological Modeling of an Emerging Forest Disease: Spread of Sudden Oak Death applied in a GIS to real-world wildland landscapes. In this paper, we present and evaluate a GIS model was implemented (1990-2005) in a GIS to simulate disease spread across California at a spatial

  13. Automated segmentation of lungs with severe interstitial lung disease in CT

    E-Print Network [OSTI]

    Automated segmentation of lungs with severe interstitial lung disease in CT Jiahui Wang Department: Accurate segmentation of lungs with severe interstitial lung disease ILD in thoracic computed tomography CT developed in this study a texture analysis-based method for accurate segmentation of lungs with severe ILD

  14. South Carolina Pest Management Handbook for Field Crops -2015 SOYBEAN DISEASE CONTROL

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 259 SOYBEAN DISEASE CONTROL John D years. Soybean Rust is active in South Carolina primarily after mid-August in most years. Soybean South Carolina Soybean Production Guide for information on accurate identification of diseases based

  15. Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2

    E-Print Network [OSTI]

    Watson, Craig A.

    FA181 Lymphocystis Disease in Fish1 Roy P. E. Yanong, VMD2 1. This document is FA181, one and marine fishes caused by infection with an iridovirus known as Lymphocystivirus or Lymphocystis disease does not cause significant mortalities, it does cause unsightly growths on fish that reduce

  16. Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

    E-Print Network [OSTI]

    Morimoto, Richard

    Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding Daniela Martino homeostasis components that direct protein folding and function. To identify global principles of misfolding. In diseased cells, maladaptation alters protein structure­function relationships, impacts protein folding

  17. Thesis proposal CSF Brazil 2014 Dendrimers as new drugs against neglected tropical diseases

    E-Print Network [OSTI]

    Bordenave, Charles

    Thesis proposal CSF Brazil 2014 Title: Dendrimers as new drugs against neglected tropical diseases America, particularly in Brazil. The #12;disease is severe in people with weakened immune systems, finding new medications is of high interest both for France and Brazil. We propose to use dendrimers

  18. Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed countries

    E-Print Network [OSTI]

    Cai, Long

    Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed in the lungs. However, characteristic to both forms of the disease is the airway- wall accumulation of T helper are expressed either by skin8 or lung epithelial cells and can influence the way in which epithelial cells

  19. Assessing Patient Case Management Services with Adult Congenital Heart Disease Sensed Data

    E-Print Network [OSTI]

    Roussos, George

    1 Assessing Patient Case Management Services with Adult Congenital Heart Disease Sensed Data · Clinicians: Doctors & Nurses 7 How do Patients use Panaceia-iTV? Follow a treatment plan that includes-iTV Pilot Sites Brompton Hospital, London Adult Congenital Heart Center, Congenital Heart Disease Patients

  20. New Florida Cattle Identification Program to Protect Florida's Cattle Industry; Mitigate Spread of Disease

    E-Print Network [OSTI]

    Hill, Jeffrey E.

    New Florida Cattle Identification Program to Protect Florida's Cattle Industry; Mitigate Spread. In the past, Florida cattle have struggled with animal disease outbreaks, such as Brucellosis and Tuberculosis and those diseases, present in other states, still threaten our cattle today. The Florida Department

  1. A new shoot and stem disease of Eucalyptus species caused by Erwinia psidii

    E-Print Network [OSTI]

    A new shoot and stem disease of Eucalyptus species caused by Erwinia psidii T. A. Coutinho & C. L Eucalyptus grandis, E. dunnii, E. globulus and E. globulus subsp. maidenii has been observed in plantations previously observed on any species of Eucalyptus. In this study, we describe the symptoms of this new disease

  2. Mycosphaerella leaf disease (MLD) outbreak on Eucalyptus globulus in Brazil caused by Teratosphaeria (Mycosphaerella) nubilosa

    E-Print Network [OSTI]

    302 Mycosphaerella leaf disease (MLD) outbreak on Eucalyptus globulus in Brazil caused of young plantations of Eucalyptus globulus trees showing symptoms resembling My- cosphaerella leaf disease spread of T. nubilosa northwards into Brazil's main Eucalyptus-growing areas as well as to other South

  3. Plant Disease / June 2005 659 Relative Pathogenicity of Cryphonectria cubensis on Eucalyptus Clones

    E-Print Network [OSTI]

    Plant Disease / June 2005 659 Relative Pathogenicity of Cryphonectria cubensis on Eucalyptus Clones canker disease on Eucalyptus species in many tropical and subtropical areas of the world (2/year) and tem- peratures above 23°C (5,12,23). Since Eucalyptus is one of the major plantation trees

  4. Root and Root Collar Disease of Eucalyptus grandis Caused by Pythium splendens

    E-Print Network [OSTI]

    Root and Root Collar Disease of Eucalyptus grandis Caused by Pythium splendens 125 C. LINDE, M. J. H. J. 1994. Root and root collar disease of Eucalyptus gramlis caused by Pythium spJendens. Plant trees. P. splendens inoculated on two different clones of E. grandis and on Eucalyptus fastigata

  5. An Adaptive, Knowledge-Driven Medical Image Search Engine for Interactive Diffuse Parenchymal Lung Disease

    E-Print Network [OSTI]

    Chandy, John A.

    An Adaptive, Knowledge-Driven Medical Image Search Engine for Interactive Diffuse Parenchymal Lung Abstract Characterization and quantification of the severity of diffuse parenchymal lung diseases (DPLD have been obtained on a small test set. Keywords: CT; texture analysis; interstitial lung disease

  6. Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060

    E-Print Network [OSTI]

    Feres, Renato

    Monte Carlo Simulation of Alzheimer's Disease in the United States: 2010-2060 Michael Blech concerns facing the United States over the next 50 years. This progressive disease is currently the sixth on the United States population, and second, the simulation models both prevalence and mortality. Both

  7. Plant Disease / September 2002 939939 Differential Response of Selected Peanut (Arachis hypogaea) Genotypes

    E-Print Network [OSTI]

    Pappu, Hanu R.

    Plant Disease / September 2002 939939 Differential Response of Selected Peanut (Arachis hypogaea species of thrips (18). In the United States, the virus has become a major con- straint to peanut disease in peanut was made possible by identifying and combining some critical management tactics

  8. South Carolina Pest Management Handbook for Field Crops -2015 PEANUT DISEASE MANAGEMENT

    E-Print Network [OSTI]

    Stuart, Steven J.

    South Carolina Pest Management Handbook for Field Crops - 2015 184 PEANUT DISEASE MANAGEMENT Jay W. Chapin, Extension Peanut Specialist Emeritus Seedling Diseases: All peanut seed should be treated to peanuts by thrips, primarily tobacco thrips. TSWV reduces yield and causes shriveled, misshapen pods. All

  9. Health and Disease in East Africa Course Syllabus; Spring 2011 Interdisciplinary Perspectives on

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Health and Disease in East Africa Course Syllabus; Spring 2011 1 Interdisciplinary Perspectives on Global Health and Disease: Uganda PHS 644: Section 30 Course Syllabus ­ Spring 2012 Wednesdays 5 Prerequisites: Graduate and health professional students who plan field study in Uganda and/or East Africa

  10. Monitoring Insect and Disease Impacts on Rangeland Oaks in California1

    E-Print Network [OSTI]

    information has been compiled on the relative importance and overall impacts of diseases and arthropods A. Bernhardt Richard A. Arnold2 Abstract: We developed methods to assess the impacts of diseases and arthropods on sapling and mature rangeland oaks, and applied these methods at 18 sample plot locations

  11. BETWEEN DESTINY AND DISEASE: GENETICS AND MOLECULAR PATHWAYS OF CENTRAL NERVOUS SYSTEM AGING

    E-Print Network [OSTI]

    Sibille, Etienne

    BETWEEN DESTINY AND DISEASE: GENETICS AND MOLECULAR PATHWAYS OF CENTRAL NERVOUS SYSTEM AGING BETWEEN DESTINY AND DISEASE: GENETICS AND MOLECULAR PATHWAYS OF CNS AGING Christin Ann Glorioso, Ph.D. University of Pittsburgh, 2010 Human brain aging is associated with robust "normal" functional, structural

  12. The aging-disease false dichotomy: understanding senescence as pathology Journal Name: Frontiers in Genetics

    E-Print Network [OSTI]

    Gems, David

    The aging-disease false dichotomy: understanding senescence as pathology David Gems Journal Name.frontiersin.org Citation: Gems D(2015) The aging-disease false dichotomy: understanding senescence as pathology. Front formatted PDF and full text (HTML) versions will be made available soon. Genetics of Aging #12;1 The aging

  13. Milk production and distribution in low-dose counties for the Hanford Thyroid Disease Study

    SciTech Connect (OSTI)

    Schimmel, J.G. . Social and Economic Sciences Research Center); Beck, D.M. )

    1992-06-01

    This report identifies sources of milk consumed by residents of Ferry, Okanogan, and Stevens Counties. This information will be used by the Hanford thyroid Disease Study to determine whether thyroid disease has been increased among people exposed to past iodine--131 emissions from Hanford Site Facilities.

  14. Annosus Root Disease in Europe and the Southeastern United States: Occurrence, Research, and Historical Perspective'

    E-Print Network [OSTI]

    History #12;Annosus Root Disease in Europe and the Southeastern United States: Occurrence disease in Europe and the southeastern United States is reviewed in prefacing the focus. This mode of spread has accounted for a long history of damage in Europe where losses occur as: (1

  15. Metabonomic Profiling of TASTPM Transgenic Alzheimer's Disease Mouse Model

    SciTech Connect (OSTI)

    Hu, Zeping; Browne, Edward R.; Liu, Tao; Angel, Thomas E.; Ho, Paul C.; Chun Yong Chan, Eric

    2012-12-07

    Identification of molecular mechanisms underlying early stage Alzheimer’s disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, non-targeted metabotyping of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild type mice (Q28 Y = 0.587 and 0.766 for PLS-DA models derived from brain and plasma, respectively). A number of metabolites were found to be perturbed in TASTPM mice in both brain (D11 fructose, L-valine, L-serine, L-threonine, zymosterol) and plasma (D-glucose, D12 galactose, linoleic acid, arachidonic acid, palmitic acid and D-gluconic acid). In addition, enzyme immunoassay confirmed that selected endogenous steroids were significantly perturbed in brain (androstenedione and 17-OH-progesterone) and plasma (cortisol and testosterone) of TASTPM mice. Ingenuity pathway analysis revealed that perturbations related to amino acid metabolism (brain), steroid biosynthesis (brain), linoleic acid metabolism (plasma) and energy metabolism (plasma) accounted for the differentiation of TASTPM and wild-type

  16. Toxicological and pharmacological concerns on oxidative stress and related diseases

    SciTech Connect (OSTI)

    Saeidnia, Soodabeh; Abdollahi, Mohammad

    2013-12-15

    Although reactive oxygen species (ROS) such as superoxide, hydrogen peroxide and hydroxyl radical are generated as the natural byproduct of normal oxygen metabolism, they can create oxidative damage via interaction with bio-molecules. The role of oxidative stress as a remarkable upstream part is frequently reported in the signaling cascade of inflammation as well as chemo attractant production. Even though hydrogen peroxide can control cell signaling and stimulate cell proliferation at low levels, in higher concentrations it can initiate apoptosis and in very high levels may create necrosis. So far, the role of ROS in cellular damage and death is well documented with implicating in a broad range of degenerative alterations e.g. carcinogenesis, aging and other oxidative stress related diseases (OSRDs). Reversely, it is cleared that antioxidants are potentially able to suppress (at least in part) the immune system and to enhance the normal cellular protective responses to tissue damage. In this review, we aimed to provide insights on diverse OSRDs, which are correlated with the concept of oxidative stress as well as its cellular effects that can be inhibited by antioxidants. Resveratrol, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, statins, nebivolol and carvedilol, pentaerythritol tetranitrate, mitochondria-targeted antioxidants, and plant-derived drugs (alone or combined) are the potential medicines that can be used to control OSRD.

  17. Sedation-assisted Orthopedic Reduction in Emergency Medicine: The Safety and Success of a One Physician/One Nurse Model

    E-Print Network [OSTI]

    Vinson, David R; Hoehn, Casey

    2013-01-01

    of Emergency Physicians (ACEP) and the Emergency Nurses42 Contrary to the ACEP policy, some felt credentialed,oversight. 50-53 In 2010 ACEP, ENA, and the American Academy

  18. Mechanical Assessment of Veterinary Orthopedic Implant Technologies: Comparative Studies of Canine Fracture Fixation and Equine Arthrodesis Devices and Techniques 

    E-Print Network [OSTI]

    Baker, Sean Travis

    2013-04-30

    Plate (LCP) was compared to a 14-16 hole broad Dynamic Compression Plate (DCP). Both constructs used a two “figure-eight” 1.25mm stainless steel wire tension band. Fatigue tests and to failure tests were conducted. There were no significant differences...

  19. Health Detectives: Uncovering the Mysteries of Disease (LBNL Science at the Theater)

    ScienceCinema (OSTI)

    Bissell, Mina; Canaria, Christie; Celnicker, Susan; Karpen, Gary

    2014-05-06

    In this April 23, 2012 Science at the Theater event, Berkeley Lab scientists discuss how they uncover the mysteries of disease in unlikely places. Speakers and topics include: World-renowned cancer researcher Mina Bissell's pioneering research on the role of the cellular microenvironment in breast cancer has changed the conversation about the disease. How does DNA instability cause disease? To find out, Christie Canaria images neural networks to study disorders such as Huntington's disease. Fruit flies can tell us a lot about ourselves. Susan Celniker explores the fruit fly genome to learn how our genome works. DNA is not destiny. Gary Karpen explores how environmental factors shape genome function and disease through epigenetics.

  20. Delays in Reducing Waterborne and Water-related Infectious Diseases in China under Climate Change

    SciTech Connect (OSTI)

    Hodges, Maggie; Belle, Jessica; Carlton, Elizabeth; Liang, Song; Li, Huazhong; Luo, Wei; Freeman, Matthew C.; Liu, Yang; Gao, Yang; Hess, Jeremy; Remais, Justin V.

    2014-12-01

    Despite China’s rapid progress improving water, sanitation and hygiene (WSH) infrastructure and access, in 2011, 471 million people lacked access to improved sanitation, and 401 million people lacked access to household piped water. Infectious diseases are sensitive to changes in climate, particularly temperature, and WSH conditions. To explore possible impacts of climate change on these diseases in China in 2020 and 2030, we coupled estimates of the temperature sensitivity of diarrheal disease and three vector-borne diseases, temperature projections from global climate models using four emissions pathways, WSH-infrastructure development scenarios and projected demographic changes. By 2030, the projected impacts would delay China’s historically rapid progress toward reducing the burden of WSH-attributable infectious disease by 8-85 months. This developmental delay provides a key summary measure of the impact of climate change in China, and in other societies undergoing rapid social, economic, and environmental change.

  1. Development of an indirect competitive ELISA for the detection of protective antibodies in pasteurella pneumonia 

    E-Print Network [OSTI]

    Sewell, Julie Elizabeth

    1996-01-01

    haemolytica in Bovine Respiratory Disease. . . . . Pathogenesis of Bovine Respiratory Disease Virulence Factors of Pasteurella haemolytica. 3 3 4 5 7 MATERIALS AND METHODS . 12 Sample Collection Antigen Preparation . Bovine Anti... of bacteria. ' There are twenty-eight or more different viruses that can be involved in bovine respiratory disease. The most important of these are infectious bovine rhinotmcheitis (IBR) virus, parainfluenza-3 (PI-3) virus, bovine viral diarrhea (BVD) virus...

  2. Mineral density volume gradients in normal and diseased human tissues

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Djomehri, Sabra I.; Candell, Susan; Case, Thomas; Browning, Alyssa; Marshall, Grayson W.; Yun, Wenbing; Lau, S. H.; Webb, Samuel; Ho, Sunita P.; Aikawa, Elena

    2015-04-09

    Clinical computed tomography provides a single mineral density (MD) value for heterogeneous calcified tissues containing early and late stage pathologic formations. The novel aspect of this study is that, it extends current quantitative methods of mapping mineral density gradients to three dimensions, discretizes early and late mineralized stages, identifies elemental distribution in discretized volumes, and correlates measured MD with respective calcium (Ca) to phosphorus (P) and Ca to zinc (Zn) elemental ratios. To accomplish this, MD variations identified using polychromatic radiation from a high resolution micro-computed tomography (micro-CT) benchtop unit were correlated with elemental mapping obtained from a microprobe X-raymore »fluorescence (XRF) using synchrotron monochromatic radiation. Digital segmentation of tomograms from normal and diseased tissues (N=5 per group; 40-60 year old males) contained significant mineral density variations (enamel: 2820-3095mg/cc, bone: 570-1415mg/cc, cementum: 1240-1340mg/cc, dentin: 1480-1590mg/cc, cementum affected by periodontitis: 1100-1220mg/cc, hypomineralized carious dentin: 345-1450mg/cc, hypermineralized carious dentin: 1815-2740mg/cc, and dental calculus: 1290-1770mg/cc). A plausible linear correlation between segmented MD volumes and elemental ratios within these volumes was established, and Ca/P ratios for dentin (1.49), hypomineralized dentin (0.32-0.46), cementum (1.51), and bone (1.68) were observed. Furthermore, varying Ca/Zn ratios were distinguished in adapted compared to normal tissues, such as in bone (855-2765) and in cementum (595-990), highlighting Zn as an influential element in prompting observed adaptive properties. Hence, results provide insights on mineral density gradients with elemental concentrations and elemental footprints that in turn could aid in elucidating mechanistic processes for pathologic formations.« less

  3. Disease mapping based on stochastic SIR-SI model for Dengue and Chikungunya in Malaysia

    SciTech Connect (OSTI)

    Samat, N. A.; Ma'arof, S. H. Mohd Imam

    2014-12-04

    This paper describes and demonstrates a method for relative risk estimation which is based on the stochastic SIR-SI vector-borne infectious disease transmission model specifically for Dengue and Chikungunya diseases in Malaysia. Firstly, the common compartmental model for vector-borne infectious disease transmission called the SIR-SI model (susceptible-infective-recovered for human populations; susceptible-infective for vector populations) is presented. This is followed by the explanations on the stochastic SIR-SI model which involve the Bayesian description. This stochastic model then is used in the relative risk formulation in order to obtain the posterior relative risk estimation. Then, this relative estimation model is demonstrated using Dengue and Chikungunya data of Malaysia. The viruses of these diseases are transmitted by the same type of female vector mosquito named Aedes Aegypti and Aedes Albopictus. Finally, the findings of the analysis of relative risk estimation for both Dengue and Chikungunya diseases are presented, compared and displayed in graphs and maps. The distribution from risk maps show the high and low risk area of Dengue and Chikungunya diseases occurrence. This map can be used as a tool for the prevention and control strategies for both diseases.

  4. Development of a Discrete Spatial-Temporal SEIR Simulator for Modeling Infectious Diseases

    SciTech Connect (OSTI)

    McKenna, S.A.

    2000-11-01

    Multiple techniques have been developed to model the temporal evolution of infectious diseases. Some of these techniques have also been adapted to model the spatial evolution of the disease. This report examines the application of one such technique, the SEIR model, to the spatial and temporal evolution of disease. Applications of the SEIR model are reviewed briefly and an adaptation to the traditional SEIR model is presented. This adaptation allows for modeling the spatial evolution of the disease stages at the individual level. The transmission of the disease between individuals is modeled explicitly through the use of exposure likelihood functions rather than the global transmission rate applied to populations in the traditional implementation of the SEIR model. These adaptations allow for the consideration of spatially variable (heterogeneous) susceptibility and immunity within the population. The adaptations also allow for modeling both contagious and non-contagious diseases. The results of a number of numerical experiments to explore the effect of model parameters on the spread of an example disease are presented.

  5. Tissue-engineered canine mitral valve constructs as In vitro research models for myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Liu, Mengmeng

    2014-11-28

    Myxomatous mitral valve disease (MMVD) is one of the most common degenerative cardiac diseases affecting humans and dogs; however, its pathogenesis is not completely understood. This study focussed on developing ...

  6. Understanding Foodborne Disease Outbreaks Using Environmental Assessments Kristin C. Delea,* Carol A. Selman, and EHS-Net

    E-Print Network [OSTI]

    Understanding Foodborne Disease Outbreaks Using Environmental Assessments Kristin C. Delea,* Carol foodborne disease surveillance system. The environmental assessments of these investigations provide food environmental assessments. Methods The study was conducted by the Environmental Health Specialists Network (EHS

  7. Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease

    E-Print Network [OSTI]

    Ananthakrishnan, Ashwin N.

    AB Background: Vitamin D may have an immunologic role in Crohn's disease (CD) and ulcerative colitis (UC). Retrospective studies suggested a weak association between vitamin D status and disease activity but have significant ...

  8. Non-toxic concentrations of ?-synuclein exacerbate Parkinson's disease-like cell death by inducing mitochondrial dysfunction 

    E-Print Network [OSTI]

    Williamson, Sally Joanne Mary

    2008-01-01

    ?-Synuclein (?-syn), is a self-aggregating protein that has been identified as a pathologically important component in a number of diseases, such as Parkinson’s disease (PD). PD, a progressive neurological disorder ...

  9. Genome-wide analysis of Marek's disease virus proteins and their role in modulating the innate immune response in chickens 

    E-Print Network [OSTI]

    Hassanin, Ola

    2010-01-01

    Marek’s disease virus (MDV), the causative agent of Marek’s disease in chicken, is an important oncogenic avian pathogen which leads to world-wide economic losses in the poultry industry. It targets the chicken's immune ...

  10. Identification of novel genetic determinants in the high prevalence early-onset inflammatory bowel disease population in Scotland 

    E-Print Network [OSTI]

    Limbergen, Johan Emiel van

    2010-01-01

    Background & aims: The inflammatory bowel diseases (IBD), Crohn?s disease (CD) and ulcerative colitis (UC), are common causes of chronic gastrointestinal morbidity, affecting up to 1 in 250 of the general population in ...

  11. Chaperone networks: Tipping the balance in protein folding diseases Cindy Voisine, Jesper Sndergaard Pedersen, Richard I. Morimoto

    E-Print Network [OSTI]

    Morimoto, Richard

    Review Chaperone networks: Tipping the balance in protein folding diseases Cindy Voisine, Jesper . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Molecular chaperones and protein folding quality control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 C. elegans models of diseases of protein folding

  12. Urine Protein Analysis and Correlation of Urinary Biomarkers with Renal Disease Progression in Dogs with X-Linked Hereditary Nephropathy 

    E-Print Network [OSTI]

    Nabity, Mary B.

    2012-02-14

    Chronic kidney disease (CKD) is a major cause of illness in dogs, and it is commonly caused by glomerular diseases that result in proteinuria and a progressive decline in renal function. Despite the importance of glomerular ...

  13. Large-scale epidemiological data on cardiovascular diseases and diabetes in migrant and ethnic minority groups in Europe 

    E-Print Network [OSTI]

    Rafnsson, Snorri B; Bhopal, Raj

    2009-01-01

    Data on differences by ethnicity in cardiovascular diseases (CVDs) and diabetes, reflecting the influence of diverse cultural, social and religious factors, are important to providing clues to disease aetiology and ...

  14. The Effects of Disease-Induced Juvenile Mortality on the Transient and Asymptotic Population Dynamics of Chinook Salmon (Oncorhynchus tshawytscha) 

    E-Print Network [OSTI]

    Fujiwara, Masami; Mohr, Michael S.; Greenberg, Aaron

    2014-01-10

    The effects of an increased disease mortality rate on the transient and asymptotic dynamics of Chinook salmon (Oncorhynchus tshawytscha) were investigated. Disease-induced mortality of juvenile salmon has become a serious concern in recent years...

  15. Quantifying the patient population of ultra-orphan diseases: a case study in X-Linked Hypohidrotic Ectodermal Dysplasia

    E-Print Network [OSTI]

    Hermann, Julie (Julie Lynn)

    2011-01-01

    Understanding the true incidence and prevalence of a disease has tremendous value for the biopharmaceutical industry, particularly for orphan diseases that affect a minority of the population (in the US, the definition of ...

  16. Cancer diseases are among the leading cause of death in the United States. Advanced cancer diseases are characterized by genetic defects resulting in uncontrollable cell growth. Currently, chemotherapeutics are one

    E-Print Network [OSTI]

    Cancer diseases are among the leading cause of death in the United States. Advanced cancer diseases of the mainstream treatments administered to cancer patients but are less effective if administered in the later with cancer diseases, by administering genes which encode for proteins that result in cell death. While

  17. The Social Cost of the Health Effects of Motor-Vehicle Air Pollution

    E-Print Network [OSTI]

    McCubbin, Donald R.; Delucchi, Mark A.

    1996-01-01

    Victor E. (1990). "Air Pollution and Fatal Lung Disease inEffects of Photochemical Oxidant Air Pollution in Exercisinget alo (1992). "Air Pollution and Respiratory Symptoms in

  18. Medical Screening Protocol for the Former Worker Medical Screening...

    Broader source: Energy.gov (indexed) [DOE]

    recommendations; repeat CT scan offered on an annual basis after initial baseline Welding Lung Asthma Chronic obstructive lung disease Respiratory symptoms...

  19. Existence of patchiness in constricted lungs : from experiments to complex system modeling

    E-Print Network [OSTI]

    Wongviriyawong, Chanikarn Mint

    2012-01-01

    Understanding asthma pathophysiology can directly help researchers and physicians pinpoint mechanisms that govern airway hyperresponsiveness and effectively treat complex respiratory diseases such as asthma. The advancement ...

  20. 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    receives NIH grant for respiratory disease diagnostic device October 19, 2011 LOS ALAMOS, New Mexico, October 19, 2011-A spinoff of Los Alamos National Laboratory, Mesa Tech, has...