Sample records for respiratory disease orthopedic

  1. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01T23:59:59.000Z

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  2. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01T23:59:59.000Z

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  3. Building-associated risk of febrile acute respiratory diseases in Army trainees

    SciTech Connect (OSTI)

    Brundage, J.F.; Scott, R.M.; Lednar, W.M.; Smith, D.W.; Miller, R.N.

    1988-04-08T23:59:59.000Z

    Airborne transmission of infectious agents and associations of indoor air pollutants with respiratory illnesses are well documented. We hypothesized that energy conservation measures that tighten buildings also increase risks of respiratory infection among building occupants. At four Army training centers during a 47-month period, incidence rates of febrile acute respiratory disease were compared between basic trainees in modern (energy-efficient design and construction) and old barracks. Rates of febrile acute respiratory disease were significantly higher among trainees in modern barracks (adjusted relative risk estimate, 1.51; 95% confidence interval, 1.46 to 1.56), and relative risks were consistent at the four centers. These results support the hypothesis that tight buildings with closed ventilation systems significantly increase risks of respiratory-transmitted infection among congregated, immunologically susceptible occupants.

  4. Respiratory disease and particulate air pollution in Santiago Chile: Contribution of erosion particles from fine sediments

    E-Print Network [OSTI]

    Commentary Respiratory disease and particulate air pollution in Santiago Chile: Contribution pollution Santiago Erosion Sedimentation a b s t r a c t Air pollution in Santiago is a serious problem for a couple of days, followed by extreme levels of air pollution. Current regulations focus mostly on PM10

  5. National Center for Immunization and Respiratory Diseases No More Excuses

    E-Print Network [OSTI]

    Liblit, Ben

    to protect yourself and your family. If you miss getting your flu vaccine in the fall, make it a New Year Vaccine WrongThe flu (influenza) is a contagious disease which affects the lungs and can lead to serious protect against non-flu viruses. · Oryoumighthavebeenexposedtoflu after you got vaccinated but before

  6. Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein

    E-Print Network [OSTI]

    Herlihy, Sarah E

    2014-06-05T23:59:59.000Z

    the model organism Dictyostelium and the protein AprA allows us to study chalone signaling mechanisms. Acute Respiratory Distress Syndrome (ARDS) is characterized by an excess influx of neutrophils into the lungs. Neutrophils damage the lung tissue...

  7. Prevalence of respiratory symptoms and diseases in schoolchildren living in a polluted and in a low polluted area in Israel

    SciTech Connect (OSTI)

    Goren, A.I.; Hellmann, S.

    1988-02-01T23:59:59.000Z

    Second and fifth grade schoolchildren living in two communities with different levels of air pollution were studied. The parents of these children filled out ATS-NHLI health questionnaires. The prevalence of reported respiratory symptoms and pulmonary diseases was found to be significantly higher among children growing up in the polluted community (Ashdod) as compared with the low-pollution area (Hadera). Logistic models fitted for the respiratory conditions which differed significantly between both areas of residence also included background variables that could be responsible for these differences. Relative risk values, which were calculated from the logistic models, were in the range of 1.47 for cough without cold to 2.66 for asthma for children from Ashdod, as compared with 1.00 for children from Hadera.

  8. Correlation of Klebsiella pneumoniae Comparative Genetic Analyses with Virulence Profiles in a Murine Respiratory Disease Model

    E-Print Network [OSTI]

    Fodah, Ramy A.

    Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied ...

  9. acidosis respiratory: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pulmonary Disease (COPD) as a proxy for respiratory across small urban areas or individuals. Keywords: Respiratory health, Chronic obstructive pulmonary disease, Cities,...

  10. Effects of Air Pollution on Respiratory Disease Asthma, closely associated with air pollution, affects nearly 15 million people in the United States, one-third of them

    E-Print Network [OSTI]

    Schladow, S. Geoffrey

    Effects of Air Pollution on Respiratory Disease Asthma, closely associated with air pollution as a greater understanding of the types of air pollutants that cause the most harm. Seminal findings, supporting a proposed update to existing air quality standards. Air pollutant ozone causes childhood asthma

  11. CFD modeling and image analysis of exhaled aerosols due to a growing bronchial tumor: Towards non-invasive diagnosis and treatment of respiratory obstructive diseases

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xi, Jinxiang; Kim, JongWon; Si, Xiuhua A.; Corley, Richard A.; Kabilan, Senthil; Wang, Shengyu

    2015-01-01T23:59:59.000Z

    Diagnosis and prognosis of tumorigenesis are generally performed with CT, PET, or biopsy. Such methods are accurate, but have the limitations of high cost and posing additional health risks to patients. In this study, we introduce an alternative computer aided diagnostic tool that can locate malignant sites caused by tumorigenesis in a non-invasive and low-cost way. Our hypothesis is that exhaled aerosol distribution is unique to lung structure and is sensitive to airway structure variations. With appropriate approaches, it is possible to locate the disease site, determine the disease severity, and subsequently formulate a targeted drug delivery plan to treatmore »the disease. This study numerically evaluated the feasibility of the proposed breath test in an image-based lung model with varying pathological stages of a bronchial squamous tumor. Large eddy simulations and a Lagrangian tracking approach were used to model respiratory airflows and aerosol dynamics. Respirations of tracer aerosols of 1 ?m at a flow rate of 20 L/min were simulated, with the distributions of exhaled aerosols recorded on a filter at the mouth exit. Aerosol patterns were quantified with multiple analytical techniques such as concentration disparity, spatial scanning and fractal analysis. We demonstrated that a growing bronchial tumor induced notable variations in both the airflow and exhaled aerosol distribution. These variations became more apparent with increasing tumor severity. The exhaled aerosols exhibited distinctive pattern parameters such as spatial probability, fractal dimension, and multifractal spectrum. Results of this study show that morphometric measures of the exhaled aerosol pattern can be used to detect and monitor the pathological states of respiratory diseases in the upper airway. The proposed breath test also has the potential to locate the site of the disease, which is critical in developing a personalized, site-specific drug delivery protocol.« less

  12. deprivation respiratory

    E-Print Network [OSTI]

    Yang, Junfeng

    measured oxidation administration mechanism capacity binding intake pregnancy system deficient quality activity nocturnal treatment duration respiratory daytime pattern circadian normal problem function mechanism baseline disturbance apnoea cat delta analysis temperature parameter shift human states

  13. Executive Summary The University of Wisconsin Orthopedic Funds are part of the University of Wisconsin

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Executive Summary The University of Wisconsin Orthopedic Funds are part of the University, and rehabilitation of musculoskeletal injuries and conditions. Vision The University of Wisconsin Orthopedic Funds possible care for patients. Strategic Priorities The University of Wisconsin Orthopedic Funds will support

  14. Respiratory Mechanisms of Support

    E-Print Network [OSTI]

    Kay, Mark A.

    Respiratory Mechanisms of Support Nasal Cannula Hi Flow Nasal Cannula CPAP Continuous positive the respiratory system is working to compensate for a metabolic issue so as to normalize the blood pH. HCO3 - 22 uses PIP Mechanical Ventilation: Volume vs. Pressure: Volume Control Pressure Control Cycle Volume Time

  15. Evaluation of Biomimetic and Alloy-based Materials for Orthopedic Applications

    E-Print Network [OSTI]

    Guiza-Arguello, Viviana R.

    2013-07-17T23:59:59.000Z

    be biocompatible and not initiate tissue reactions or immune responses. This work focuses on the evaluation of the biocompatibility of novel alloy-based materials for orthopedic applications. In addition, in the context of bone regeneration, it examines...

  16. Improved performance of ultra-high molecular weight polyethylene for orthopedic applications

    E-Print Network [OSTI]

    Plumlee, Kevin Grant

    2009-05-15T23:59:59.000Z

    two alternate approaches to improving the wear performance of UHMWPE in orthopedic applications Previous work has shown that UHMWPE-based composites have wear resistance comparable to the irradiation-crosslinked polymer. Zirconium has been shown...

  17. Development of an orthopedic load cell for stress analysis of a canine tibia

    E-Print Network [OSTI]

    Green, Bryan Wade

    1988-01-01T23:59:59.000Z

    DEVELOPMENT OF AN ORTHOPEDIC LOAD CELL FOR STRESS ANALYSIS OF A CANINE TIBIA A Thesis by BRYAN WADE GREEN Submitted to the Office of Graduate Studies Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE December 1988 Major Subject: Civil Engineering DEVELOPMENT OF AN ORTHOPEDIC LOAD CELL FOR STRESS ANALYSIS OF A CANINE TIBIA A Thesis by Bryan Wade Green Approved as to style and content by: Y:- Z James K. Nels'on, Jr. / (Chair committee...

  18. Bovine Respiratory Disease Max Irsik DVM, MAB

    E-Print Network [OSTI]

    Watson, Craig A.

    . The clinical signs are usually mild and involve coughing, nasal discharge, fever and a decreased appetite signs of BRD are nasal and eye discharges, coughing, fever, depressed appetite, varying degrees

  19. Multiplex detection of respiratory pathogens

    DOE Patents [OSTI]

    McBride, Mary (Brentwood, CA); Slezak, Thomas (Livermore, CA); Birch, James M. (Albany, CA)

    2012-07-31T23:59:59.000Z

    Described are kits and methods useful for detection of respiratory pathogens (influenza A (including subtyping capability for H1, H3, H5 and H7 subtypes) influenza B, parainfluenza (type 2), respiratory syncytial virus, and adenovirus) in a sample. Genomic sequence information from the respiratory pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay to successfully identify the presence or absence of pathogens in a sample.

  20. Respiratory protection at nuclear power plants

    SciTech Connect (OSTI)

    Reinert, B.D.

    1982-01-01T23:59:59.000Z

    Highlights of the respiratory protection research and development program conducted at Los Alamos is reviewed. (ACR)

  1. Respiratory correlated cone beam CT

    SciTech Connect (OSTI)

    Sonke, Jan-Jakob; Zijp, Lambert; Remeijer, Peter; Herk, Marcel van [Department of Radiation Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam (Netherlands)

    2005-04-01T23:59:59.000Z

    A cone beam computed tomography (CBCT) scanner integrated with a linear accelerator is a powerful tool for image guided radiotherapy. Respiratory motion, however, induces artifacts in CBCT, while the respiratory correlated procedures, developed to reduce motion artifacts in axial and helical CT are not suitable for such CBCT scanners. We have developed an alternative respiratory correlated procedure for CBCT and evaluated its performance. This respiratory correlated CBCT procedure consists of retrospective sorting in projection space, yielding subsets of projections that each corresponds to a certain breathing phase. Subsequently, these subsets are reconstructed into a four-dimensional (4D) CBCT dataset. The breathing signal, required for respiratory correlation, was directly extracted from the 2D projection data, removing the need for an additional respiratory monitor system. Due to the reduced number of projections per phase, the contrast-to-noise ratio in a 4D scan reduced by a factor 2.6-3.7 compared to a 3D scan based on all projections. Projection data of a spherical phantom moving with a 3 and 5 s period with and without simulated breathing irregularities were acquired and reconstructed into 3D and 4D CBCT datasets. The positional deviations of the phantoms center of gravity between 4D CBCT and fluoroscopy were small: 0.13{+-}0.09 mm for the regular motion and 0.39{+-}0.24 mm for the irregular motion. Motion artifacts, clearly present in the 3D CBCT datasets, were substantially reduced in the 4D datasets, even in the presence of breathing irregularities, such that the shape of the moving structures could be identified more accurately. Moreover, the 4D CBCT dataset provided information on the 3D trajectory of the moving structures, absent in the 3D data. Considerable breathing irregularities, however, substantially reduces the image quality. Data presented for three different lung cancer patients were in line with the results obtained from the phantom study. In conclusion, we have successfully implemented a respiratory correlated CBCT procedure yielding a 4D dataset. With respiratory correlated CBCT on a linear accelerator, the mean position, trajectory, and shape of a moving tumor can be verified just prior to treatment. Such verification reduces respiration induced geometrical uncertainties, enabling safe delivery of 4D radiotherapy such as gated radiotherapy with small margins.

  2. Nitric oxide and carbon monoxide in cigarette smoke in the development of cardiorespiratory disease in smokers

    E-Print Network [OSTI]

    Borland, Colin David Ross

    1988-10-18T23:59:59.000Z

    Flow Obstruction Smokers may suffer from a spectrum of respiratory disorders ranging from the near universal morning cough to respiratory failure. Much difficulty in understanding the natural history of these diseases results from the different...

  3. Navajo Coal Combustion and Respiratory Health Near Shiprock, New Mexico

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bunnell, Joseph E.; Garcia, Linda V.; Furst, Jill M.; Lerch, Harry; Olea, Ricardo A.; Suitt, Stephen E.; Kolker, Allan

    2010-01-01T23:59:59.000Z

    Indoor air pollution has been identified as a major risk factor for acute and chronic respiratory diseases throughout the world. In the sovereign Navajo Nation, an American Indian reservation located in the Four Corners area of the USA, people burn coal in their homes for heat. To explore whether/how indoor coal combustion might contribute to poor respiratory health of residents, this study examined respiratory health data, identified household risk factors such as fuel and stove type and use, analyzed samples of locally used coal, and measured and characterized fine particulate airborne matter inside selected homes. In twenty-five percent of homesmore »surveyed coal was burned in stoves not designed for that fuel, and indoor air quality was frequently found to be of a level to raise concerns. The average winter 24-hourPM2.5concentration in 20 homes was 36.0??g/m3. This is the first time thatPM2.5has been quantified and characterized inside Navajo reservation residents' homes.« less

  4. MULTISCALE MODELING OF THE RESPIRATORY TRACT

    E-Print Network [OSTI]

    Maury, Bertrand

    correspond to di®erent mechanical models. The resulting system is described by the NavierÀStokes equation of the respiratory tree into three stages where di®erent models will be exploited and in which the mechanicalMULTISCALE MODELING OF THE RESPIRATORY TRACT LEONARDO BAFFICO Laboratoire de Mathematiques N

  5. Effects of air pollution on the respiratory health of children: a cross-sectional study

    SciTech Connect (OSTI)

    Spinaci, S.; Arossa, W.; Bugiani, M.; Natale, P.; Bucca, C.; de Candussio, G.

    1985-09-01T23:59:59.000Z

    To investigate the effects of air pollution on the respiratory health of children, a subject of some controversy, a comparative study was undertaken of 2,385 school children who lived in central urban, peripheral urban, and suburban areas. Daily monitoring of sulfur dioxide and total suspended particle concentrations in all areas showed that pollutant concentrations in central and peripheral urban areas were above commonly accepted safety levels for respiratory health, while concentrations in the suburban area were within acceptable limits. A questionnaire administered to each mother assessed environmental exposure to pollutants in the household, the occurrence of respiratory symptoms as well as lung diseases as diagnosed by a physician, and general information. Children were interviewed about smoking habits and any acute respiratory symptoms. Children also performed standard lung function tests. Results showed that children from both urban areas had lessened pulmonary function and a higher prevalence of bronchial secretion with common colds than did those from the suburban area. These differences persisted after corrections for exposure to indoor pollutants, active or passive smoking, socioeconomic status, and sex. Parental cigarette smoking was related to a fall in forced expiratory volume in 1 second and an increased incidence of acute respiratory illnesses and chronic cough in children. Although boys had higher lung volumes and lower air flow, regression analysis showed no significant influence of the interactions sex-geographic area and sex-smoking on lung function. It was concluded that air pollution has a significant effect on the respiratory health of children.

  6. Elec 331 -Respiratory System SRC: AnatomyWarehouse.com

    E-Print Network [OSTI]

    Pulfrey, David L.

    - Respiratory System 4 Mechanics of Breathing Lung Visceral Pleura (attached to lung) Parietal Pleura (attachedElec 331 - Respiratory System 1 SRC: AnatomyWarehouse.com C-V / Respiratory System Hot Water #12;Elec 331 - Respiratory System 2 Alveoli Pharynx (throat) Larynx (voice box / Adam's Apple) Trachea

  7. Clinical correlates and epidemiology of respiratory viruses 

    E-Print Network [OSTI]

    Gaunt, Eleanor

    2011-07-05T23:59:59.000Z

    The introduction of the polymerase chain reaction (PCR) into the diagnostic setting has provided unprecedented opportunities in the field of respiratory medicine, not only because pathogens need no longer be cultivable ...

  8. allergic respiratory diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Caroline; F. Dawes 38 MODELING AND MECHANISTIC INSIGHTS INTO THE DEVELOPMENT OF ALLERGIC AIRWAY RESPONSES TO HOUSE DUST MITE. Open Access Theses and Dissertations Summary: ??...

  9. LANL spinoff receives NIH grant for respiratory disease diagnostic device

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your Home as ReadyAppointedKyungmin2010 topLANLLANLLANL spinoff

  10. Porcine Reproductive and Respiratory Syndrome 

    E-Print Network [OSTI]

    Lawhorn, D. Bruce

    2001-07-25T23:59:59.000Z

    weaned! Seventeen-week-old pigs typically weighed only 70 to 80 pounds, and the prospect of continuing problems with pneumonia in nursery, grower, and finisher pigs was too much. The producer decided to depopulate. At the time this large Texas herd... is not known. Antibiotics in semen kill only bacteria; they are not effective against viruses such as PRRS. Is disease from PRRS virus infection always as bad as the infection of the large Texas herd that had to depopulate in 1993? No. Swine herd disease...

  11. Revision of the ICRP dosimetric model for the human respiratory tract

    SciTech Connect (OSTI)

    Bair, W.J.

    1990-12-01T23:59:59.000Z

    Although the dosimetric model of the respiratory tract used in ICRP Publication 30 had not been shown to be seriously deficient for the purpose of calculating Annual Limits on Intake (ALIs) for workers, the availability of new information led the ICRP in 1984 to create a special Task Group to review the dosimetric model of the respiratory tract and, if justified, propose revisions or a new model. The Task Group directed its efforts toward improving the model used in Publication 30 rather than developing a completely new model. The objective was a model that would facilitate calculation of biologically meaningful doses; be consistent with morphological, physiological, and radiobiological characteristics of the respiratory tract; incorporate current knowledge; meet all radiation protection needs; be user friendly by not being unnecessarily sophisticated; be adaptable to development of computer software for calculation of relevant radiation doses from knowledge of a few readily measured exposure parameters; be equally useful for assessment purposes as for calculating ALIs; be applicable to all members of the world population; and consider the influence of smoking, air pollutants, and diseases of the inhalation, deposition, and clearance of radioactive particles from the respiratory tract. The model provides for calculation of a committed dose equivalent for each region, adjusted for the relative cancer sensitivity of that region, and for the summing of these to yield a committed dose equivalent for the entire respiratory tract. 3 figs.

  12. Ann Occup Hyg . Author manuscript Asbestos-related diseases in automobile mechanics

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Ann Occup Hyg . Author manuscript Page /1 7 Asbestos-related diseases in automobile mechanics Abstract Purpose Automobile mechanics have been exposed to asbestos number of automobile mechanics, little is known about the non-malignant respiratory diseases observed

  13. Mitochondrial Respiratory Capacity Is a Critical Regulator

    E-Print Network [OSTI]

    respiratory capacity (SRC). SRC is the extra capacity available in cells to produce energy in response. In response to antigen (Ag) and costimulation, CD8+ T cells undergo a developmental program characterized- ating in response to Ag, it is thought that quiescent T cells (e.g., naive and memory T cells), like

  14. Modeling the Dynamics of Fermentation and Respiratory

    E-Print Network [OSTI]

    Sheffield, University of

    , denitrification, and SO4-reduction). The accumulation of acetate as a fermentation product within the plume species, e.g., H2(aq) or acetate, followed by respiration by other groups of organisms where fermentationModeling the Dynamics of Fermentation and Respiratory Processes in a Groundwater Plume of Phenolic

  15. Separating respiratory influences from the tachogram: methods and their sensitivity to the type of respiratory signal

    E-Print Network [OSTI]

    ECG- derived respiratory (EDR) signals. The sensitivity of both separation methods to the type signals. Even when an EDR signal obtained using kernel principal com- ponent analysis is used, OSP yields

  16. REGULAR ARTICLE A Simple Dynamic Model of Respiratory Pump

    E-Print Network [OSTI]

    Fontecave-Jallon, Julie

    ). Mathematical models are used to understand these interactions and the mechanics of respiratory system better) and introduce some dynamic properties of the respiratory system. The passive elements (rib cage and abdomen not take into account the dynamic component of the system, it appears valid for different respiratory

  17. Nitrogen dioxide and respiratory illnesses in infants

    SciTech Connect (OSTI)

    Samet, J.M.; Lambert, W.E.; Skipper, B.J.; Cushing, A.H.; Hunt, W.C.; Young, S.A.; McLaren, L.C.; Schwab, M.; Spengler, J.D. (Univ. of New Mexico Medical Center, Albuquerque (United States))

    1993-11-01T23:59:59.000Z

    Nitrogen dioxide is an oxidant gas that contaminates outdoor air and indoor air in homes with unvented gas appliances. A prospective cohort study was carried out to test the hypothesis that residential exposure to NO2 increases incidence and severity of respiratory illnesses during the first 18 months of life. A cohort of 1,205 healthy infants from homes without smokers was enrolled. The daily occurrence of respiratory symptoms and illnesses was reported by the mothers every 2 wk. Illnesses with wheezing or wet cough were classified as lower respiratory tract. Indoor NO2 concentrations were serially measured with passive samplers place in the subjects' bedrooms. In stratified analyses, illness incidence rates did not consistently increase with exposure to NO2 or stove type. In multivariate analyses that adjusted for potential confounding factors, odds ratios were not significantly elevated for current or lagged NO2 exposures, or stove type. Illness duration, a measure of illness severity, was not associated with NO2 exposure. The findings can be extended to homes with gas stoves in regions of the United States where the outdoor air is not heavily polluted by NO2.

  18. A software toolkit for acoustic respiratory analysis

    E-Print Network [OSTI]

    Yi, Gina Ann

    2004-01-01T23:59:59.000Z

    Millions of Americans suffer from pulmonary diseases. According to recent statistics, approximately 17 million people suffer from asthma, 16.4 million from chronic obstructive pulmonary disease, 12 million from sleep apnea, ...

  19. Participatory epidemiology : harnessing the HealthMap platform for community-based disease outbreak monitoring

    E-Print Network [OSTI]

    Freifeld, Clark

    2010-01-01T23:59:59.000Z

    Due to increasing global trade and travel along with a range of environmental factors, emerging infectious diseases such as Severe Acute Respiratory Syndrome (SARS), drug-resistant tuberculosis, and 2009 HiNi continue to ...

  20. The effects of mechanical ventilation on the development of Acute Respiratory Distress Syndrome

    E-Print Network [OSTI]

    Jia, Xiaoming, M. Eng. Massachusetts Institute of Technology

    2007-01-01T23:59:59.000Z

    Acute Respiratory Distress Syndrome (ARDS) is a severe lung illness characterized by inflammation and fluid accumulation in the respiratory system. Historically, ARDS and other forms of respiratory failure have been treated ...

  1. Respiratory and Cardiovascular Adjustments to Exercise in Reptiles

    E-Print Network [OSTI]

    Bennett, Albert F.

    challenges to the respiratory system of reptiles. Incrementing aerobic metabolism above resting levelsRespiratory and Cardiovascular Adjustments to Exercise in Reptiles T.T. GLEESON ' and A.F. BEN NETT all levels of activity (Fig. lb). The mechanism for an- aerobic energy production during exercise

  2. Multiscale modelling of the respiratory tract C. Grandmont

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    to different mechanical models. The resulting system is described by the Navier-Stokes equation coupledMultiscale modelling of the respiratory tract L. Baffico C. Grandmont B. Maury§ February 20, 2009 Abstract We propose here a decomposition of the respiratory tree into three stages which correspond

  3. INTRODUCTION Insects breathe using a tracheal respiratory system. The tracheal

    E-Print Network [OSTI]

    Socha, Jake

    2293 INTRODUCTION Insects breathe using a tracheal respiratory system. The tracheal system consists of the spiracular valves convectively deliver oxygen to the tissues. The tracheal respiratory system is efficient flow through the tracheal system (Harrison, 2009). During hypoxia, abdominal pumping often increases

  4. The Relationship Between the Prevalence of Respiratory Illness and Dermatitis and Infant Diet in the First Year of Life

    E-Print Network [OSTI]

    Kunz, Lara

    2009-04-09T23:59:59.000Z

    for asthma and allergic disease since the 12th century when a Jewish physician and philosopher, Maimonides, produced a remedy of Rhazes to ?clear the lungs of moisture, ease respiration and eliminate the cough? (32). The relationship of the environment...-wheezing lower respiratory infections included chest infection, pneumonia, whooping cough, chronic cough, or croup. As a check for reliability and validity of parental reporting of illnesses, the investigators compared 100 hospital medical records against...

  5. Conf Proc IEEE Eng Med Biol Soc. Author manuscript A model of ventilation used to interpret newborn lamb respiratory signals

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Mechanics ; physiology ; Sheep Introduction Respiratory problems are particularly frequent in the neonatal of the neonatal respiratory system is yet available.. Mathematical modeling, which integrates interacting respiratory dynamics. Functionally, the mammalian respiratory system is made of three components: ventilation

  6. Respiratory arsenate reductase as a bidirectional enzyme

    SciTech Connect (OSTI)

    Richey, Christine [Department of Biological Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282 (United States)] [Department of Biological Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282 (United States); Chovanec, Peter [Department of Biological Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282 (United States) [Department of Biological Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282 (United States); Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282 (United States); Hoeft, Shelley E.; Oremland, Ronald S. [U.S. Geological Survey, 345 Middlefield Rd., MS 480, Menlo Park, CA 94025 (United States)] [U.S. Geological Survey, 345 Middlefield Rd., MS 480, Menlo Park, CA 94025 (United States); Basu, Partha [Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282 (United States)] [Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282 (United States); Stolz, John F., E-mail: stolz@duq.edu [Department of Biological Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282 (United States)

    2009-05-01T23:59:59.000Z

    The haloalkaliphilic bacterium Alkalilimnicola ehrlichii is capable of anaerobic chemolithoautotrophic growth by coupling the oxidation of arsenite (As(III)) to the reduction of nitrate and carbon dioxide. Analysis of its complete genome indicates that it lacks a conventional arsenite oxidase (Aox), but instead possesses two operons that each encode a putative respiratory arsenate reductase (Arr). Here we show that one homolog is expressed under chemolithoautotrophic conditions and exhibits both arsenite oxidase and arsenate reductase activity. We also demonstrate that Arr from two arsenate respiring bacteria, Alkaliphilus oremlandii and Shewanella sp. strain ANA-3, is also biochemically reversible. Thus Arr can function as a reductase or oxidase. Its physiological role in a specific organism, however, may depend on the electron potentials of the molybdenum center and [Fe-S] clusters, additional subunits, or constitution of the electron transfer chain. This versatility further underscores the ubiquity and antiquity of microbial arsenic metabolism.

  7. Chronic respiratory effects of indoor formaldehyde exposure

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Quackenboss, J.J.; Lebowitz, M.D.

    1990-01-01T23:59:59.000Z

    The relation of chronic respiratory symptoms and pulmonary function to formaldehyde (HCHO) in homes was studied in a sample of 298 children (6-15 years of age) and 613 adults. HCHO measurements were made with passive samplers two one-week periods. Data on chronic cough and phlegm, wheeze, attacks of breathlessness, and doctor diagnoses of chronic bronchitis and asthma were collected with self-completed questionnaires. Peak expiratory flow rates (PEFR) were obtained during the evenings and mornings for up to 14 consecutive days for each individual. Significantly greater prevalence rates of asthma and chronic bronchitis were found in children from houses with HCHO levels 60-120 ppb than in those less exposed, especially in children also exposed to environmental tobacco smoke. In children, levels of PEFR linearly decreased with HCHO exposure, with estimated decrease due to 60 ppb of HCHO equivalent to 22% of PEFR level in nonexposed children.

  8. NICS report links VOCs to respiratory problems

    SciTech Connect (OSTI)

    Kirschner, E.

    1992-04-22T23:59:59.000Z

    Children who live near the chemical plants of Kanawha Valley, WV, suffer more acute and chronic respiratory aliments than those farther away, says a Harvard University School of Public Health report. In the $1-million, five-year study commissioned by the National Institute for Chemical Studies (NICS:Charleston, WV) and funded by the Environmental Protection Agency, proximity to chemical plants that emit volatile organic compounds (VOCs) was linked to higher incidence of asthma, acute eye irritation, shortness of breath, and chronic cough. The researchers say they adjusted for most other factors, such as parental smoking and petroleum. {open_quotes}The research hypothesis was whether children in the valley had more symptoms,{close_quotes} says NICS president Paul Hill. {open_quotes}Yes, there is a difference.{close_quotes} The study showed that some ailments were up to 28% more prevalent in children in the valley than in other Kanawha County children.

  9. Occupational exposures and chronic respiratory symptoms. A population-based study

    SciTech Connect (OSTI)

    Korn, R.J.; Dockery, D.W.; Speizer, F.E.; Ware, J.H.; Ferris, B.G. Jr.

    1987-08-01T23:59:59.000Z

    Data from a random sample of 8515 white adults residing in 6 cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms; 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalences of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared with unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR = 1.53, 95% Cl = 1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory symptoms and disease can be independently associated with occupational exposures.

  10. Occupational exposures and chronic respiratory symptoms: a population-based study

    SciTech Connect (OSTI)

    Korn, R.J.; Dockery, D.W.; Speizer, F.E.; Ware, J.H.; Ferris, B.G.

    1987-01-01T23:59:59.000Z

    Data from a random sample of 8515 white adults residing in six cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms. 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or to fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalence of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared to unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease (COPD) as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR=1.53, 95% CI=1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory disease can be independently associated with occupational exposures.

  11. BE 508: Quantitative Studies of Respiratory and Cardiovascular Systems Spring Semester, 2013

    E-Print Network [OSTI]

    Vajda, Sandor

    1 BE 508: Quantitative Studies of Respiratory and Cardiovascular Systems Spring Semester, 2013 of the respiratory system (1 lecture) (Bates, Ch 1) 2. Measurement of respiratory function (2 lectures) (Bates, Ch 2 mechanics (1 lecture) (Bates, Ch 5) 4. Inverse modeling of respiratory mechanics, part 1 (2 lectures) (Bates

  12. acute hypoxemic respiratory: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 13 Evidence of...

  13. acute respiratory syndrome: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 7 Management of...

  14. acute respiratory symptoms: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 16 Evidence of...

  15. acute respiratory illness: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 4 Edinburgh Research...

  16. acute respiratory acidosis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 12 Evidence of...

  17. acute viral respiratory: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 15 Evidence of...

  18. acute hypoxaemic respiratory: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 11 Evidence of...

  19. acute bacterial respiratory: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 13 Evidence of...

  20. alternative respiratory syndromes: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 10 Management of...

  1. acute respiratory allergen: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 11 Evidence of...

  2. acute respiratory bronchiolitis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 11 Evidence of...

  3. Measuring the mechanical properties of the respiratory system in patients

    E-Print Network [OSTI]

    Hayden, Nancy J.

    the lungs such that their frequency content lies in a range above that encompassed by the regular's lungs. · Only system capable of convenient, ongoing assessment of respiratory mechanical function

  4. Chronic respiratory effects of indoor formaldehyde exposure

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Quackenboss, J.J.; Lebowitz, M.D. (Univ. of Arizona Health Sciences Center, Tucson (USA))

    1990-08-01T23:59:59.000Z

    The relation of chronic respiratory symptoms and pulmonary function to formaldehyde (HCHO) in homes was studied in a sample of 298 children (6-15 years of age) and 613 adults. HCHO measurements were made with passive samplers during two 1-week periods. Data on chronic cough and phlegm, wheeze, attacks of breathlessness, and doctor diagnoses of chronic bronchitis and asthma were collected with self-completed questionnaires. Peak expiratory flow rates (PEFR) were obtained during the evenings and mornings for up to 14 consecutive days for each individual. Significantly greater prevalence rates of asthma and chronic bronchitis were found in children from houses with HCHO levels 60-120 ppb than in those less exposed, especially in children also exposed to environmental tobacco smoke. In children, levels of PEFR decreased linearly with HCHO exposure, with the estimated decrease due to 60 ppb of HCHO equivalent to 22% of PEFR level in nonexposed children. The effects in asthmatic children exposed to HCHO below 50 ppb were greater than in healthy ones. The effects in adults were less evident: decrements in PEFR due to HCHO over 40 ppb were seen only in the morning, and mainly in smokers.

  5. A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells

    E-Print Network [OSTI]

    Shaham, Oded

    Mutations in either the mitochondrial or nuclear genomes can give rise to respiratory chain disease (RCD), a large class of devastating metabolic disorders. Their clinical management is challenging, in part because we lack ...

  6. Respiratory Amplitude Guided 4-Dimensional Magnetic Resonance Imaging

    SciTech Connect (OSTI)

    Hu, Yanle, E-mail: yhu@radonc.wustl.edu [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States)] [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Caruthers, Shelton D. [Department of Medicine, Washington University School of Medicine, St. Louis, Missouri (United States)] [Department of Medicine, Washington University School of Medicine, St. Louis, Missouri (United States); Low, Daniel A. [Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California (United States)] [Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California (United States); Parikh, Parag J.; Mutic, Sasa [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States)] [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States)

    2013-05-01T23:59:59.000Z

    Purpose: To evaluate the feasibility of prospectively guiding 4-dimensional (4D) magnetic resonance imaging (MRI) image acquisition using triggers at preselected respiratory amplitudes to achieve T{sub 2} weighting for abdominal motion tracking. Methods and Materials: A respiratory amplitude-based triggering system was developed and integrated into a commercial turbo spin echo MRI sequence. Initial feasibility tests were performed on healthy human study participants. Four respiratory states, the middle and the end of inhalation and exhalation, were used to trigger 4D MRI image acquisition of the liver. To achieve T{sub 2} weighting, the echo time and repetition time were set to 75 milliseconds and 4108 milliseconds, respectively. Single-shot acquisition, together with parallel imaging and partial k-space imaging techniques, was used to improve image acquisition efficiency. 4D MRI image sets composed of axial or sagittal slices were acquired. Results: Respiratory data measured and logged by the MRI scanner showed that the triggers occurred at the appropriate respiratory levels. Liver motion could be easily observed on both 4D MRI image datasets by sensing either the change of liver in size and shape (axial) or diaphragm motion (sagittal). Both 4D MRI image datasets were T{sub 2}-weighted as expected. Conclusions: This study demonstrated the feasibility of achieving T{sub 2}-weighted 4D MRI images using amplitude-based respiratory triggers. With the aid of the respiratory amplitude-based triggering system, the proposed method is compatible with most MRI sequences and therefore has the potential to improve tumor-tissue contrast in abdominal tumor motion imaging.

  7. Human torso phantom for imaging of heart with realistic modes of cardiac and respiratory motion

    DOE Patents [OSTI]

    Boutchko, Rostyslav; Balakrishnan, Karthikayan; Gullberg, Grant T; O'Neil, James P

    2013-09-17T23:59:59.000Z

    A human torso phantom and its construction, wherein the phantom mimics respiratory and cardiac cycles in a human allowing acquisition of medical imaging data under conditions simulating patient cardiac and respiratory motion.

  8. What is the flu? Influenza, "the flu" is a contagious respiratory infection

    E-Print Network [OSTI]

    Virginia Tech

    What is the flu? Influenza, "the flu" is a contagious respiratory infection caused by the influenza medications are used. How is flu spread? The influenza virus is very contagious and is spread by respiratory

  9. INTRODUCTION Insects exchange respiratory gases through a complex network of

    E-Print Network [OSTI]

    Socha, Jake

    3409 INTRODUCTION Insects exchange respiratory gases through a complex network of tracheal tubes through the tracheal system using diffusion alone (Krogh, 1920a; Weis-Fogh, 1964), many species are known to augment gas exchange using convection (Buck, 1962; Miller, 1966a). Two general mechanisms are recognized

  10. Department of Environmental Health and Instructional Safety Respiratory Protection

    E-Print Network [OSTI]

    de Lijser, Peter

    . Seal Check. 5. Respiratory Fit Testing. 6. Inspection Procedures. 7. Cleaning and Storage Instructions example, to retard spoilage in fruit storage areas), or when oxygen is displaced by a heavier gas or vapor, ammonia, propane, etc. Some processes that use high temperatures (like welding) can involve reactions

  11. Modelling a Respiratory Central Pattern Generator Neuron in Lymnaea stagnalis

    E-Print Network [OSTI]

    Campbell, Sue Ann

    Modelling a Respiratory Central Pattern Generator Neuron in Lymnaea stagnalis Sharene D. Bungay, is characterized in part by its ability to take in oxygen both cutaneously and aerially (via its rudi- mentary lung by a 3-neuron central pattern generator (CPG) as depicted in Figure 1. Syed et al. [1, 2] were able

  12. Analysis of Cardio-respiratory Dynamics during Mental Stress using (Partial) Time-Frequency Spectra

    E-Print Network [OSTI]

    important to determine the mechanisms un- derlying stress. In this paper, we aim at studying the cardio-respiratory to conduct a combined analysis of the cardio-respiratory system. In this study, we will perform cross timeAnalysis of Cardio-respiratory Dynamics during Mental Stress using (Partial) Time-Frequency Spectra

  13. Respiratory impairment and symptoms as predictors of early retirement with disability in US underground coal miners

    SciTech Connect (OSTI)

    Ames, R.G.; Trent, R.B.

    1984-08-01T23:59:59.000Z

    A five-year prospective study of 1,394 United States underground coal miners was undertaken to study the effects of respiratory impairment on the rate of early retirement with disability (ERD). Using a logistic regression analysis, ERD was found to be related to reported persistent phlegm after adjustment was made for other respiratory symptoms, respiratory function measurements, cigarette smoking, and some demographic characteristics. No prediction of ERD occurred for spirometrically determined measures of respiratory function. The data thus give limited support to the hypothesis that early retirement with disability in underground coal miners can be predicted prospectively by measures of respiratory symptoms.

  14. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  15. Effects of inhalable particles on respiratory health of children

    SciTech Connect (OSTI)

    Dockery, D.W.; Speizer, F.E.; Stram, D.O.; Ware, J.H.; Spengler, J.D.; Ferris, B.G. Jr.

    1989-03-01T23:59:59.000Z

    Results are presented from a second cross-sectional assessment of the association of air pollution with chronic respiratory health of children participating in the Six Cities Study of Air Pollution and Health. Air pollution measurements collected at quality-controlled monitoring stations included total suspended particulates (TSP), particulate matter less than 15 microns (PM15) and 2.5 microns (PM2.5) aerodynamic diameter, fine fraction aerosol sulfate (FSO4), SO2, O3, and No2. Reported rates of chronic cough, bronchitis, and chest illness during the 1980-1981 school year were positively associated with all measures of particulate pollution (TSP, PM15, PM2.5, and FSO4) and positively but less strongly associated with concentrations of two of the gases (SO2 and NO2). Frequency of earache also tended to be associated with particulate concentrations, but no associations were found with asthma, persistent wheeze, hay fever, or nonrespiratory illness. No associations were found between pollutant concentrations and any of the pulmonary function measures considered (FVC, FEV1, FEV0.75, and MMEF). Children with a history of wheeze or asthma had a much higher prevalence of respiratory symptoms, and there was some evidence that the association between air pollutant concentrations and symptom rates was stronger among children with these markers for hyperreactive airways. These data provide further evidence that rates of respiratory illnesses and symptoms are elevated among children living in cities with high particulate pollution. They also suggest that children with hyperreactive airways may be particularly susceptible to other respiratory symptoms when exposed to these pollutants.

  16. A linear time-varying simulation of the respiratory system

    E-Print Network [OSTI]

    Hernandez, Oscar Renato

    1993-01-01T23:59:59.000Z

    aerosols with constant transfer rates in a linear distribution of compartments representing three physiological regions of the respiratory system. This approach was selected by the Task Group to simplify nonlinear parameters such as macrophage uptake... of the action of physicochemical and biological factors that play a role in converting aerosol particles to a chemical form that is absorbed to the blood. In this research, using the same compartmental distribution as that proposed by the ICRP Task Group, a...

  17. About the Air Pollution and Respiratory Health Program The Air Pollution and Respiratory Health Program of the National Center for Environmental Health, Centers for

    E-Print Network [OSTI]

    About the Air Pollution and Respiratory Health Program The Air Pollution and Respiratory Health indoor and outdoor air pollution. CDC's asthma program focuses on three main activities: (1) tracking public health agencies. For example, CDC staff are currently studying the effect of outdoor air pollution

  18. Van de Louw et al. Respiratory Research 2010, 11:38 http://respiratory-research.com/content/11/1/38

    E-Print Network [OSTI]

    Boyer, Edmond

    Van de Louw et al. Respiratory Research 2010, 11:38 http://respiratory-research.com/content/11 cardiovascular variability and baroreflex gain in mechanically ventilated patients Andry Van de Louw*1,2, Claire nervous system. During spontaneous breathing, the application of positive end- expiratory pressure (PEEP

  19. Pediatric Respiratory Infectious Disease Analysis: UTM-RT versus Flocked Swab Nasal Collections

    E-Print Network [OSTI]

    2008-01-01T23:59:59.000Z

    the efficacy of the specimen collection methods. PredictingCA Background: The collection of anterior nasal washingsFlocked Swab Nasal Collections Paul Walsh 1 , Christina Lim

  20. Identification and characterization of a virus isolated from bobwhite quail with a respiratory disease

    E-Print Network [OSTI]

    DuBose, Robert Trafton

    1958-01-01T23:59:59.000Z

    $ Desori t 0 of the Diss ~ The outbreak of quail bronchitis reported by Olson ooeurre4 21 in 1949 at the Best Virgixd. a State Game Farm. Coughing and unseeing was observed in some of the adult bobshite quail, In young bixds spnptons first eccurred... at $ weeks of age. Foe4 con suaptien droype4 and coughing, encasing an4 tales were noto4. Basal disoharge was not seen. Bending cf the neck between tho wings or legs occurred in 2 to ) yoreent of the birds. The course of the dieoase was 1 to $ weeks...

  1. Linking Two Seemingly Unrelated Diseases, Cancer and Acute Respiratory Distress Syndrome, Through a Dictyostelium Secreted Protein 

    E-Print Network [OSTI]

    Herlihy, Sarah E

    2014-06-05T23:59:59.000Z

    the sensitivity of SAP ....................... 162 Discussion .................................................................................................................. 163 APPENDIX E RBLA IS REQUIRED FOR APRA PROLIFERATION INHIBITION... Figure 33: Sodium chloride and PD fluid, but not sodium lactate, interfere with the ability of SAP to inhibit fibrocyte differentiation. ......................................... 163 Figure 34: RblA facilitates bacterial proliferation and colony...

  2. Evaluation of Two Methods to Prevent Bovine Respiratory Disease in Growing Cattle

    E-Print Network [OSTI]

    Word, Alyssa Brook

    2014-07-09T23:59:59.000Z

    of 1.2 kg while healthy animals gained 1.4 kg (McNeill, 2000). Although a definitive test does not exist for the diagnosis BRD, DMI and ADG may provide indicators of an animal’s overall health. Once an animal becomes sick with BRD, the economic... early detection or a more quantitative approach to predicting and diagnosing BRD. Ideally, a chute side test would be available to ascertain the risk of an individual animal developing BRD. Alternatively, quantitative assessment could be developed...

  3. Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report

    E-Print Network [OSTI]

    McCormick, Liam M; Goddard, Martin; Mahadeva, Ravi

    2008-08-05T23:59:59.000Z

    welding history. In 3 years of follow-up his lung function and chest radiograph have not progressed. Discussion Inhalation of iron compounds occurs commonly in paint factories, during welding and steelmaking, and at various stages of iron mining and iron... ' contributions LM participated in the design and coordination of the case report and drafted the manuscript. MG acquired, analysed and reported on the histopathological slides. RM con- ceived of the case report, participated in its design and coordination...

  4. SU-E-I-75: Evaluation of An Orthopedic Metal Artifact Reduction (O-MAR) Algorithm On Patients with Spinal Prostheses Near Spinal Tumors

    SciTech Connect (OSTI)

    Shen, Z; Xia, P; Djemil, T [Cleveland Clinic, Cleveland, OH (United States); Klahr, P [Philips Healthcare, Cleveland, OH (United States)

    2014-06-01T23:59:59.000Z

    Purpose: To evaluate the impact of a commercial orthopedic metal artifact reduction (O-MAR) algorithm on CT image quality and dose calculation for patients with spinal prostheses near spinal tumors. Methods: A CT electron density phantom was scanned twice: with tissue-simulating inserts only, and with a titanium insert replacing solid water. A patient plan was mapped to the phantom images in two ways: with the titanium inside or outside of the spinal tumor. Pinnacle and Eclipse were used to evaluate the dosimetric effects of O-MAR on 12-bit and 16-bit CT data, respectively. CT images from five patients with spinal prostheses were reconstructed with and without O-MAR. Two observers assessed the image quality improvement from O-MAR. Both pencil beam and Monte Carlo dose calculation in iPlan were used for the patient study. The percentage differences between non-OMAR and O-MAR datasets were calculated for PTV-min, PTV-max, PTV-mean, PTV-V100, PTV-D90, OAR-V10Gy, OAR-max, and OAR-D0.1cc. Results: O-MAR improved image quality but did not significantly affect the dose distributions and DVHs for both 12-bit and 16- bit CT phantom data. All five patient cases demonstrated some degree of image quality improvement from O-MAR, ranging from small to large metal artifact reduction. For pencil beam, the largest discrepancy was observed for OARV-10Gy at 5.4%, while the other seven parameters were ?0.6%. For Monte Carlo, the differences between non-O-MAR and O-MAR datasets were ?3.0%. Conclusion: Both phantom and patient studies indicated that O-MAR can substantially reduce metal artifacts on CT images, allowing better visualization of the anatomical structures and metal objects. The dosimetric impact of O-MAR was insignificant regardless of the metal location, image bit-depth, and dose calculation algorithm. O-MAR corrected images are recommended for radiation treatment planning on patients with spinal prostheses because of the improved image quality and no need to modify current dose constraints. This work was supported by a research grant from Philips Healthcare. Paul Klahr is an employee of Philips Healthcare.

  5. Respiratory effects of diesel exhaust in salt miners

    SciTech Connect (OSTI)

    Gamble, J.F.; Jones, W.G.

    1983-09-01T23:59:59.000Z

    The respiratory health of 259 white males working at 5 salt (NaCl) mines was assessed by questionnaire, chest radiographs, and air and He-O/sup 2/ spirometry. Response variables were symptoms, pneumoconiosis, and spirometry. Predictor variables included age, height, smoking, mine, and tenure in diesel-exposed jobs. The purpose was to assess the association of response measures of respiratory health with exposure to diesel exhaust. There were only 2 cases of Grade 1 pneumoconiosis, so no further analysis was done. Comparisons within the study population showed a statistically significant dose-related association of phlegm and diesel exposure. There was a nonsignificant trend for cough and dyspnea, and no association with spirometry. Age- and smoking-adjusted rates of cough, phlegm, and dyspnea were 145, 159, and 93% of an external comparison population. Percent predicted flow rates showed statistically significant reductions, but the reductions were small and there were no dose-response relations. Percent predicted FEV1 and FVC were about 96% of predicted.

  6. SU-E-J-48: Development of An Abdominal Compression Device for Respiratory Correlated Radiation Therapy

    SciTech Connect (OSTI)

    Kim, T; Kang, S; Kim, D; Suh, T [Catholic University Medical College, Seoul (Korea, Republic of); Kim, S [Virginia Commonwealth University, Richmond, VA (United States)

    2014-06-01T23:59:59.000Z

    Purpose: The aim of this study is to develop the abdominal compression device which could control pressure level according to the abdominal respiratory motion and evaluate its feasibility. Methods: In this study, we focused on developing the abdominal compression device which could control pressure level at any point of time so the developed device is possible to use a variety of purpose (gating technique or respiratory training system) while maintaining the merit of the existing commercial device. The compression device (air pad form) was designed to be able to compress the front and side of abdomen and the pressure level of the abdomen is controlled by air flow. Pressure level of abdomen (air flow) was determined using correlation data between external abdominal motion and respiratory volume signal measured by spirometer. In order to verify the feasibility of the device, it was necessary to confirm the correlation between the abdominal respiratory motion and respiratory volume signal and cooperation with respiratory training system also checked. Results: In the previous study, we could find that the correlation coefficient ratio between diaphragm and respiratory volume signal measured by spirometer was 0.95. In this study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion measured by belt-transducer (correlation coefficient ratio was 0.92) and used the correlated respiratory volume data as an abdominal pressure level. It was possible to control the pressure level with negligible time delay and respiratory volume data based guiding waveforms could be properly inserted into the respiratory training system. Conclusion: Through this feasibility study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion. Also initial assessment of the device and its compatibility with the respiratory training system were verified. Further study on application in respiratory gated therapy and respiratory training system will be investigated. This work was supported by Radiation Technology R and D program (No. 2013M2A2A7043498)and Basic Atomic Energy Research Institute (BAERI)(No. NRF-2009-0078390) through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning.

  7. Effects of air pollution on children's respiratory health in three Chinese cities

    SciTech Connect (OSTI)

    Qian, Z.; Chapman, R.S.; Tian, Q.; Chen, Y.; Lioy, P.J.; Zhang, J.

    2000-04-01T23:59:59.000Z

    During the winter of 1988--1989, parents of 2,789 elementary-school students completed standardized questionnaires. The students were 5--14 y of age and were from three urban districts and one suburban district of three large Chinese cities. The 4-y average ambient levels of total suspended particles in the three cities differed greatly during the period 1985--1988: Lanzhou, 1,067 {micro}g/m{sup 3}; urban Wuhan, 406 {micro}g/m{sup 3}; Guangzhou, 296 {micro}g/m{sup 3}; and suburban Wuhan, 191 {micro}g/m{sup 3}. The authors constructed unconditional logistic-regression models to calculate odds ratios and 95% confidence intervals for prevalences of several respiratory symptoms and illnesses, adjusted for district, use of coal in the home, and parental smoking status. There was a positive and significant association between total suspended particle levels and the adjusted odds ratios for couch, phlegm, hospitalization for diseases, and pneumonia. This association was derived from only the 1,784 urban children and, therefore, the authors were unable to extrapolate it to the suburban children. The results also indicated that parental smoking status was associated with cough and phlegm, and use of coal in the home was associated only with cough prevalence.

  8. Effects of ozone on the respiratory health, allergic sensitization, and cellular immune system in children

    SciTech Connect (OSTI)

    Zwick, H.; Popp, W.; Wagner, C.; Reiser, K.; Schmoeger, J.B.; Boeck, A.H.; Herkner, K.; Radunsky, K. (Pulmonary Department, Krankenhaus Lainz, Vienna (Austria))

    1991-11-01T23:59:59.000Z

    To investigate the lasting effects of high ozone concentrations under environmental conditions, we examined the respiratory health, pulmonary function, bronchial hyperresponsiveness to methacholine, allergic sensitization, and lymphocyte subpopulations of 10- to 14-yr-old children. A total of 218 children recruited from an area with high ozone concentrations (Group A) were tested against 281 children coming from an area with low ozone concentrations (Group B). As to subjective complaints, categorized as 'usually cough with or without phlegm,' 'breathlessness,' and 'susceptibility to chest colds,' there was no difference between the two groups. The lung function parameters were similar, but in Group A subjects' bronchial hyperresponsiveness occurred more frequently and was found to be more severe than in Group B (29.4 versus 19.9%, p less than 0.02; PD20 2,100 {plus minus} 87 versus 2,350 {plus minus} 58 micrograms, p less than 0.05). In both groups the number of children who had been suffering from allergic diseases and sensitization to aeroallergens, found by means of the skin test, was the same. Comparison of the total IgE levels showed no difference at all between the two groups. As far as the white blood cells are concerned, the total and differential cell count was the same, whereas lymphocyte subpopulations showed readily recognizable changes.

  9. Compensation du mouvement respiratoire dans les images TEP Respiratory motion correction in PET images

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Compensation du mouvement respiratoire dans les images TEP Respiratory motion correction in PET itérative. Abstract The quality of the Positron Emission Tomography (PET) is currently limited an integrated system to compensate respiratory motion in PET images. It is based on synchronous acquisition

  10. Modeling of the oxygen transfer in the respiratory process Sebastien Martin

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    in the acinar periphery. Introduction The respiratory system is designed to achieve two main functions: oxygenModeling of the oxygen transfer in the respiratory process S´ebastien Martin Laboratoire de Math, coupled with a lumped mechanical model for the ventilation process. Objectives. We aim at investigating

  11. The relationships between metabolic rate and the respiratory, circulatory and cellular mechanisms governing oxygen

    E-Print Network [OSTI]

    Hawai'i at Manoa, University of

    The relationships between metabolic rate and the respiratory, circulatory and cellular mechanisms governing oxygen transport from the respiratory medium to the tissues in air- breathing vertebrates have for albacore (Thunnus alalunga, 82­197mlkg-1). Plasma volume within the primary circulatory system (calculated

  12. acquired respiratory virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  13. acquired respiratory distress: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    distress is very common in cancer patients across diagnoses and across the disease trajectory. Many patients who report high levels of distress are not taking advantage of...

  14. Assessment of Autonomic Control and Respiratory Sinus Arrhythmia Using Point Process Models of Human Heart Beat Dynamics

    E-Print Network [OSTI]

    Chen, Zhe

    Tracking the autonomic control and respiratory sinus arrhythmia (RSA) from electrocardiogram and respiratory measurements is an important problem in cardiovascular control. We propose a point process adaptive filter algorithm ...

  15. Pulmonary function and respiratory symptoms in potash workers

    SciTech Connect (OSTI)

    Graham, B.L.; Dosman, J.A.; Cotton, D.J.; Weisstock, S.R.; Lappi, V.G.; Froh, F.

    1984-03-01T23:59:59.000Z

    Over 94% of the workers in each of four Saskatchewan potash mines participated in a respiratory health surveillance program that included a questionnaire and pulmonary function tests. Compared with a nonexposed control group, potash workers had higher prevalences of cough, dyspnea, and chronic bronchitis but better pulmonary function. Prevalences of symptoms and pulmonary function abnormalities were similar among workers at the four mines tested and at the various job locations. Potash dust, diesel fumes, and other air contaminants may have an irritant effect that leads to the increased prevalences of cough and chronic bronchitis. Although no adverse effects of the potash mine environment on pulmonary function were found, these findings reflect a healthy worker effect or some selection process that makes the potash workers appear healthier in a cross-sectional study.

  16. Pulmonary function and respiratory symptoms in potash workers

    SciTech Connect (OSTI)

    Graham, B.L.; Dosman, J.A.; Cotton, D.J.; Weisstock, S.R.; Lappi, V.G.; Froh, F.

    1984-03-01T23:59:59.000Z

    Over 94% of the workers in each of four Saskatchewan potash mines participated in a respiratory health surveillance program that included a questionnaire and pulmonary function tests. Compared with a nonexposed control group, potash workers had higher prevalences of cough, dyspnea, and chronic bronchitis but better pulmonary function. Prevalences of symptoms and pulmonary function abnormalities were similar among workers at the four mines tested and at the various job locations. Potash dust, diesel fumes, and other air contaminants may have an irritant effect that leads to the increased prevalences of cough and chronic bronchitis. Although we found no adverse effects of the potash mine environment on pulmonary function, these findings reflect a healthy worker effect or some selection process that makes the potash workers appear healthier in a cross-sectional study.

  17. Respiratory Physiology & Neurobiology 173S (2010) S65S73 Contents lists available at ScienceDirect

    E-Print Network [OSTI]

    Socha, Jake

    2010-01-01T23:59:59.000Z

    , and control in the insect respiratory system. © 2010 Elsevier B.V. All rights reserved. 1. IntroductionRespiratory Physiology & Neurobiology 173S (2010) S65­S73 Contents lists available at ScienceDirect Respiratory Physiology & Neurobiology journal homepage: www.elsevier.com/locate/resphysiol Review Issues

  18. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20T23:59:59.000Z

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  19. Nitrogen dioxide and respiratory illness in children. Part I: Health outcomes

    SciTech Connect (OSTI)

    Samet, J.M.; Lambert, W.E.; Skipper, B.J.; Cushing, A.H.; Hunt, W.C.; Young, S.A.; McLaren, L.C.; Schwab, M.; Spengler, J.D. (Univ. of New Mexico Medical Center, Albuquerque (United States))

    1993-06-01T23:59:59.000Z

    We have carried out a prospective cohort study to test the hypothesis that exposure to nitrogen dioxide increases the incidence and severity of respiratory infections during the first 18 months of life. Between January 1988 and June 1990, 1,315 infants were enrolled into the study at birth and followed with prospective surveillance for the occurrence of respiratory infections and monitoring of nitrogen dioxide concentrations in their homes. The subjects were healthy infants from homes without smokers; they were selected with stratification by type of cooking stove at a ratio of four to one for gas and electric stoves. Illness experience was monitored by a daily diary of symptoms completed by the mother and a telephone interview conducted every two weeks. Illnesses with wheezing or wet cough were classified as involving the lower respiratory tract; all other respiratory illnesses were designated as involving the upper respiratory tract. Exposure to nitrogen dioxide was estimated by two-week average concentrations measured in the subjects' bedrooms with passive samplers. This analysis is limited to the 1,205 subjects completing at least one month of observation; of these, 823 completed the full protocol, contributing 82.8% of the total number of days during which the subjects were under observation. Incidence rates for all respiratory illnesses, all upper respiratory illness, all lower respiratory illnesses, and lower respiratory illness further divided into those with any wheezing, or wet cough without wheezing, were examined within strata of nitrogen dioxide exposure at the time of the illness, nitrogen dioxide exposure during the prior month, and type of cooking stove. Consistent trends of increasing illness incidence rates with increasing exposure to nitrogen dioxide were not evident for either the lagged or unlagged exposure variables.

  20. Bullous Lung Disease

    E-Print Network [OSTI]

    Goldberg, Corey; Carey, Kathleen E

    2013-01-01T23:59:59.000Z

    thorascopic surgery. Bullous Lung Disease REFERENCES 1.S, Kaiser LR. Giant bullous lung disease: evaluation,for bullous disease of the lung. Eur J Cardiothorac Surg.

  1. he 20022003 epidemic of SARS (severe acute respiratory syndrome)

    E-Print Network [OSTI]

    Li, Fang

    in several genes that allowed it to be transmitted from person to person and cause lethal disease. Corona that projects from a compact core within the receptor-binding domain. Of the 14 residues on the loop

  2. Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia

    E-Print Network [OSTI]

    Pierce, Eric T.

    Quantitative evaluation of respiratory sinus arrhythmia (RSA) may provide important information in clinical practice of anesthesia and postoperative care. In this paper, we apply a point process method to assess dynamic ...

  3. Is breathing in infants chaotic? Dimension estimates for respiratory patterns during quiet sleep

    E-Print Network [OSTI]

    Judd, Kevin

    of Mathematics, University of Western Australia, Nedlands, Western Australia 6907; and 2Department of Respiratory Medicine, Princess Margaret Hospital for Children, Subiaco, Western Australia 6008, Australia Small, M., K

  4. acute respiratory syndrome-associated: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 13 Evidence of...

  5. anti-severe acute respiratory: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    syndrome. METHODS As shown in Figure 1 related to lower respiratory illness (e.g., cough, shortness of breath, pneumonia on x-ray, oxygen Boyer, Edmond 11 Evidence of...

  6. Passive cigarette smoke, coal heating, and respiratory symptoms of nonsmoking women in China

    SciTech Connect (OSTI)

    Pope, C.A. III (Harvard School of Public Health, Boston, MA (United States) Brigham Young Univ., Provo, UT (United States)); Xu, X. (Harvard School of Public Health, Boston, MA (United States))

    1993-09-01T23:59:59.000Z

    In this study the authors evaluated data from a sample of 973 never-smoking women, ages 20-40, who worked in three similar textile mills in Anhui Province, China. They compared prevalence rates of respiratory symptoms across homes with and without coal heating and homes with different numbers of smokers. Multiple logistic regression models that controlled for age, job title, and mill of employment were also estimated. Respiratory symptoms were associated with combined exposure to passive cigarette smoke and coal heating. Effects of passive cigarette smoke and coal heating on respiratory symptoms appeared to be nearly additive, suggesting a dose-response relationship between respiratory symptoms and home indoor air pollution from these two sources. The prevalence of chest illness, cough, phlegm, and shortness of breath (but not wheeze) was significantly elevated for women living in homes with both smokers and coal heating.

  7. Building-related risk factors and work-related lower respiratory symptoms in 80 office buildings

    SciTech Connect (OSTI)

    Mendell, M.J.; Naco, G.M.; Wilcox, T.G.; Sieber, W.K.

    2002-01-01T23:59:59.000Z

    We assessed building-related risk factors for lower respiratory symptoms in office workers. The National Institute for Occupational Safety and Health in 1993 collected data during indoor environmental health investigations of workplaces. We used multivariate logistic regression analyses to assess relationships between lower respiratory symptoms in office workers and risk factors plausibly related to microbiologic contamination. Among 2,435 occupants in 80 office buildings, frequent, work-related multiple lower respiratory symptoms were strongly associated, in multivariate models, with two risk factors for microbiologic contamination: poor pan drainage under cooling coils and debris in outside air intake. Associations tended to be stronger among those with a history of physician-diagnosed asthma. These findings suggest that adverse lower respiratory health effects from indoor work environments, although unusual, may occur in relation to poorly designed or maintained ventilation systems, particularly among previously diagnosed asthmatics. These findings require confirmation in more representative buildings.

  8. John Widdicombe¿s contribution to respiratory physiology and cough: reminiscences

    E-Print Network [OSTI]

    Chung, Kian Fan; Nadel, Jay A; Fontana, Giovanni

    2013-01-01T23:59:59.000Z

    But urge-to-cough is perplexing. I await confirmation orM, Widdicombe J: Fog-induced cough with impaired respiratoryJ: Desensitization of the cough reflex by exercise and

  9. Host-virus interactions in porcine reproductive and respiratory syndrome virus infection 

    E-Print Network [OSTI]

    Sorensen, George Edwin Peter

    2014-11-28T23:59:59.000Z

    Porcine reproductive and respiratory syndrome virus (PRRSV) is a rapidly evolving virus that has significant economic and welfare implications for the pig industry. Vaccination strategies have proved largely ineffective ...

  10. Association of residential dampness and mold with respiratory tract infections and bronchitis: a meta-analysis

    SciTech Connect (OSTI)

    Fisk, William J.; Eliseeva, Ekaterina A.; Mendell, Mark J.

    2010-11-15T23:59:59.000Z

    Dampness and mold have been shown in qualitative reviews to be associated with a variety of adverse respiratory health effects, including respiratory tract infections. Several published meta-analyses have provided quantitative summaries for some of these associations, but not for respiratory infections. Demonstrating a causal relationship between dampness-related agents, which are preventable exposures, and respiratory tract infections would suggest important new public health strategies. We report the results of quantitative meta-analyses of published studies that examined the association of dampness or mold in homes with respiratory infections and bronchitis. For primary studies meeting eligibility criteria, we transformed reported odds ratios (ORs) and confidence intervals (CIs) to the log scale. Both fixed and random effects models were applied to the log ORs and their variances. Most studies contained multiple estimated ORs. Models accounted for the correlation between multiple results within the studies analyzed. One set of analyses was performed with all eligible studies, and another set restricted to studies that controlled for age, gender, smoking, and socioeconomic status. Subgroups of studies were assessed to explore heterogeneity. Funnel plots were used to assess publication bias. The resulting summary estimates of ORs from random effects models based on all studies ranged from 1.38 to 1.50, with 95% CIs excluding the null in all cases. Use of different analysis models and restricting analyses based on control of multiple confounding variables changed findings only slightly. ORs (95% CIs) from random effects models using studies adjusting for major confounding variables were, for bronchitis, 1.45 (1.32-1.59); for respiratory infections, 1.44 (1.31-1.59); for respiratory infections excluding nonspecific upper respiratory infections, 1.50 (1.32-1.70), and for respiratory infections in children or infants, 1.48 (1.33-1.65). Little effect of publication bias was evident. Estimated attributable risk proportions ranged from 8% to 20%. Residential dampness and mold are associated with substantial and statistically significant increases in both respiratory infections and bronchitis. If these associations were confirmed as causal, effective control of dampness and mold in buildings would prevent a substantial proportion of respiratory infections.

  11. Respiratory motion management using audio-visual biofeedback for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery

    SciTech Connect (OSTI)

    He, Pengbo; Ma, Yuanyuan; Huang, Qiyan; Yan, Yuanlin [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000 (China); School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049 (China); Li, Qiang, E-mail: liqiang@impcas.ac.cn; Liu, Xinguo; Dai, Zhongying; Zhao, Ting; Fu, Tingyan; Shen, Guosheng [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000 (China)

    2014-11-01T23:59:59.000Z

    Purpose: To efficiently deliver respiratory-gated radiation during synchrotron-based pulsed heavy-ion radiotherapy, a novel respiratory guidance method combining a personalized audio-visual biofeedback (BFB) system, breath hold (BH), and synchrotron-based gating was designed to help patients synchronize their respiratory patterns with synchrotron pulses and to overcome typical limitations such as low efficiency, residual motion, and discomfort. Methods: In-house software was developed to acquire body surface marker positions and display BFB, gating signals, and real-time beam profiles on a LED screen. Patients were prompted to perform short BHs or short deep breath holds (SDBH) with the aid of BFB following a personalized standard BH/SDBH (stBH/stSDBH) guiding curve or their own representative BH/SDBH (reBH/reSDBH) guiding curve. A practical simulation was performed for a group of 15 volunteers to evaluate the feasibility and effectiveness of this method. Effective dose rates (EDRs), mean absolute errors between the guiding curves and the measured curves, and mean absolute deviations of the measured curves were obtained within 10%–50% duty cycles (DCs) that were synchronized with the synchrotron’s flat-top phase. Results: All maneuvers for an individual volunteer took approximately half an hour, and no one experienced discomfort during the maneuvers. Using the respiratory guidance methods, the magnitude of residual motion was almost ten times less than during nongated irradiation, and increases in the average effective dose rate by factors of 2.39–4.65, 2.39–4.59, 1.73–3.50, and 1.73–3.55 for the stBH, reBH, stSDBH, and reSDBH guiding maneuvers, respectively, were observed in contrast with conventional free breathing-based gated irradiation, depending on the respiratory-gated duty cycle settings. Conclusions: The proposed respiratory guidance method with personalized BFB was confirmed to be feasible in a group of volunteers. Increased effective dose rate and improved overall treatment precision were observed compared to conventional free breathing-based, respiratory-gated irradiation. Because breathing guidance curves could be established based on the respective average respiratory period and amplitude for each patient, it may be easier for patients to cooperate using this technique.

  12. Hemolymph lactate levels and respiratory pumping behavior in the marine gastropod, Aplysia californica 

    E-Print Network [OSTI]

    Grech, Doreen Marie

    1988-01-01T23:59:59.000Z

    HEMOLYMPH LACTATE LEVELS AND RESPIRATORY PUMPING BEHAVIOR IN THE MARINE GASTROPOD, APLYSIA CALIFORNICA A Thesis by DOREEN MARIE GRECH Submitted to the Graduate College of Texas A & M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1988 Major Subject: Biology HEMOLYMPH LACTATE LEVELS AND RESPIRATORY PUMPING BEHAVIOR IN THE MARINE GASTROPOD, APLYSIA CALIFORNICA A Thesis by DOREEN MARIE GRECH Approved as to style and content by: ames E. K z...

  13. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. (Wayne State Univ., Detroit, MI (USA))

    1990-01-01T23:59:59.000Z

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  14. Daily air pollution effects on children's respiratory symptoms and peak expiratory flow

    SciTech Connect (OSTI)

    Vedal, S.; Schenker, M.B.; Munoz, A.; Samet, J.M.; Batterman, S.; Speizer, F.E.

    1987-06-01T23:59:59.000Z

    To identify acute respiratory health effects associated with air pollution due to coal combustion, a subgroup of elementary school-aged children was selected from a large cross-sectional study and followed daily for eight months. Children were selected to obtain three equal-sized groups: one without respiratory symptoms, one with symptoms of persistent wheeze, and one with cough or phlegm production but without persistent wheeze. Parents completed a daily diary of symptoms from which illness constellations of upper respiratory illness (URI) and lower respiratory illness (LRI) and the symptom of wheeze were derived. Peak expiratory flow rate (PEFR) was measured daily for nine consecutive weeks during the eight-month study period. Maximum hourly concentrations of sulfur dioxide, nitrogen dioxide, ozone, and coefficient of haze for each 24-hour period, as well as minimum hourly temperature, were correlated with daily URI, LRI, wheeze, and PEFR using multiple regression models adjusting for illness occurrence or level of PEFR on the immediately preceding day. Respiratory illness on the preceding day was the most important predictor of current illness. A drop in temperature was associated with increased URI and LRI but not with increased wheeze or with a decrease in level of PEFR. No air pollutant was strongly associated with respiratory illness or with level of PEFR, either in the group of children as a whole, or in either of the symptomatic subgroups; the pollutant concentrations observed, however, were uniformly lower than current ambient air quality standards.

  15. Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives

    SciTech Connect (OSTI)

    Mostafalou, Sara; Abdollahi, Mohammad, E-mail: Mohammad.Abdollahi@UToronto.Ca

    2013-04-15T23:59:59.000Z

    Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action. - Highlights: ? There is a link between exposure to pesticides and incidence of chronic diseases. ? Genotoxicity and proteotoxicity are two main involved mechanisms. ? Epigenetic knowledge may help diagnose the relationships. ? Efficient policies on safe use of pesticides should be set up.

  16. Smoothing of respiratory motion traces for motion-compensated radiotherapy

    SciTech Connect (OSTI)

    Ernst, Floris; Schlaefer, Alexander; Schweikard, Achim [Institute for Robotics and Cognitive Systems, University of Luebeck, Ratzeburger Allee 160, Luebeck SH 23538 (Germany)

    2010-01-15T23:59:59.000Z

    Purpose: The CyberKnife system has been used successfully for several years to radiosurgically treat tumors without the need for stereotactic fixation or sedation of the patient. It has been shown that tumor motion in the lung, liver, and pancreas can be tracked with acceptable accuracy and repeatability. However, highly precise targeting for tumors in the lower abdomen, especially for tumors which exhibit strong motion, remains problematic. Reasons for this are manifold, like the slow tracking system operating at 26.5 Hz, and using the signal from the tracking camera ''as is''. Since the motion recorded with the camera is used to compensate for system latency by prediction and the predicted signal is subsequently used to infer the tumor position from a correlation model based on x-ray imaging of gold fiducials around the tumor, camera noise directly influences the targeting accuracy. The goal of this work is to establish the suitability of a new smoothing method for respiratory motion traces used in motion-compensated radiotherapy. The authors endeavor to show that better prediction--With a lower rms error of the predicted signal--and/or smoother prediction is possible using this method. Methods: The authors evaluated six commercially available tracking systems (NDI Aurora, PolarisClassic, Polaris Vicra, MicronTracker2 H40, FP5000, and accuTrack compact). The authors first tracked markers both stationary and while in motion to establish the systems' noise characteristics. Then the authors applied a smoothing method based on the a trous wavelet decomposition to reduce the devices' noise level. Additionally, the smoothed signal of the moving target and a motion trace from actual human respiratory motion were subjected to prediction using the MULIN and the nLMS{sub 2} algorithms. Results: The authors established that the noise distribution for a static target is Gaussian and that when the probe is moved such as to mimic human respiration, it remains Gaussian with the exception of the FP5000 and the Aurora systems. The authors also showed that the proposed smoothing method can indeed be used to filter noise. The signal's jitter dropped by as much as 95% depending on the tracking system employed. Subsequently, the 3D prediction error (rms) for a prediction horizon of 150 ms on a synthetic signal dropped by up to 37% when using a normalized LMS prediction algorithm (nLMS{sub 2}) and hardly changed when using a MULIN algorithm. When smoothing a real signal obtained in our laboratory, the improvement of prediction was similar: Up to 30% for both the nLMS{sub 2} and the best MULIN algorithm. The authors also found a noticeable increase in smoothness of the predicted signal, the relative jitter dropped by up to 95% on the real signal, and on the simulated signal. Conclusions: In conclusion, the authors can say that preprocessing of marker data is very useful in motion-compensated radiotherapy since the quality of prediction increases. This will result in better performance of the correlation model. As a side effect, since the prediction of a preprocessed signal is also less noisy, the authors expect less robot vibration resulting in better targeting accuracy and less strain on the robot gears.

  17. Respiratory triggered 4D cone-beam computed tomography: A novel method to reduce imaging dose

    SciTech Connect (OSTI)

    Cooper, Benjamin J. [Radiation Physics Laboratory, Sydney Medical School, University of Sydney, NSW 2006, Australia and Department of Medical Physics and Radiation Engineering, Canberra Hospital, Canberra, ACT 2605 (Australia); O'Brien, Ricky T.; Keall, Paul J. [Radiation Physics Laboratory, Sydney Medical School, University of Sydney, NSW 2006 (Australia); Balik, Salim; Hugo, Geoffrey D. [Radiation Oncology, Virginia Commonwealth University, 401 College Street, P.O.Box 980058, Richmond, Virginia 23298-0058 (United States)

    2013-04-15T23:59:59.000Z

    Purpose: A novel method called respiratory triggered 4D cone-beam computed tomography (RT 4D CBCT) is described whereby imaging dose can be reduced without degrading image quality. RT 4D CBCT utilizes a respiratory signal to trigger projections such that only a single projection is assigned to a given respiratory bin for each breathing cycle. In contrast, commercial 4D CBCT does not actively use the respiratory signal to minimize image dose. Methods: To compare RT 4D CBCT with conventional 4D CBCT, 3600 CBCT projections of a thorax phantom were gathered and reconstructed to generate a ground truth CBCT dataset. Simulation pairs of conventional 4D CBCT acquisitions and RT 4D CBCT acquisitions were developed assuming a sinusoidal respiratory signal which governs the selection of projections from the pool of 3600 original projections. The RT 4D CBCT acquisition triggers a single projection when the respiratory signal enters a desired acquisition bin; the conventional acquisition does not use a respiratory trigger and projections are acquired at a constant frequency. Acquisition parameters studied were breathing period, acquisition time, and imager frequency. The performance of RT 4D CBCT using phase based and displacement based sorting was also studied. Image quality was quantified by calculating difference images of the test dataset from the ground truth dataset. Imaging dose was calculated by counting projections. Results: Using phase based sorting RT 4D CBCT results in 47% less imaging dose on average compared to conventional 4D CBCT. Image quality differences were less than 4% at worst. Using displacement based sorting RT 4D CBCT results in 57% less imaging dose on average, than conventional 4D CBCT methods; however, image quality was 26% worse with RT 4D CBCT. Conclusions: Simulation studies have shown that RT 4D CBCT reduces imaging dose while maintaining comparable image quality for phase based 4D CBCT; image quality is degraded for displacement based RT 4D CBCT in its current implementation.

  18. Respiratory-Induced Prostate Motion Using Wavelet Decomposition of the Real-Time Electromagnetic Tracking Signal

    SciTech Connect (OSTI)

    Lin, Yuting [Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, California (United States); Liu, Tian; Yang, Xiaofeng [Department of Radiation Oncology, Emory University Hospital, Winship Cancer Institute, Atlanta, Georgia (United States); Wang, Yuenan [Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland (United States); Khan, Mohammad K., E-mail: drkhurram2000@gmail.com [Department of Radiation Oncology, Emory University Hospital, Winship Cancer Institute, Atlanta, Georgia (United States)

    2013-10-01T23:59:59.000Z

    Purpose: The objective of this work is to characterize and quantify the impact of respiratory-induced prostate motion. Methods and Materials: Real-time intrafraction motion is observed with the Calypso 4-dimensional nonradioactive electromagnetic tracking system (Calypso Medical Technologies, Inc. Seattle, Washington). We report the results from a total of 1024 fractions from 31 prostate cancer patients. Wavelet transform was used to decompose the signal to extract and isolate the respiratory-induced prostate motion from the total prostate displacement. Results: Our results show that the average respiratory motion larger than 0.5 mm can be observed in 68% of the fractions. Fewer than 1% of the patients showed average respiratory motion of less than 0.2 mm, whereas 99% of the patients showed average respiratory-induced motion ranging between 0.2 and 2 mm. The maximum respiratory range of motion of 3 mm or greater was seen in only 25% of the fractions. In addition, about 2% patients showed anxiety, indicated by a breathing frequency above 24 times per minute. Conclusions: Prostate motion is influenced by respiration in most fractions. Real-time intrafraction data are sensitive enough to measure the impact of respiration by use of wavelet decomposition methods. Although the average respiratory amplitude observed in this study is small, this technique provides a tool that can be useful if one moves to smaller treatment margins (?5 mm). This also opens ups the possibility of being able to develop patient specific margins, knowing that prostate motion is not unpredictable.

  19. Are you protected against Pertussis? Pertussis, or whooping cough, is a highly contagious respiratory infection caused by the bacterium

    E-Print Network [OSTI]

    Are you protected against Pertussis? Pertussis, or whooping cough, is a highly contagious respiratory infection caused by the bacterium Bordetella pertussis. It causes severe coughing spells, vomiting

  20. Hamilton study: distribution of factors confounding the relationship between air quality and respiratory health

    SciTech Connect (OSTI)

    Pengelly, L.D.; Kerigan, A.T.; Goldsmith, C.H.; Inman, E.M.

    1984-10-01T23:59:59.000Z

    Hamilton, Ontario is an industrial city with a population of 300,000 which is situated at the western end of Lake Ontario. Canada's two largest iron and steel mills are located here; the city historically has had relatively poor air quality, which has improved markedly in the last 25 years. Concern about the health effects of current air quality recently led us to carry out an epidemiological study of the effects of air pollution on the respiratory health of over 3500 school children. Respiratory health was measured by pulmonary function testing of each child, and by an assessment of each child's respiratory symptoms via a questionnaire administered to the parents. Previous studies had shown that other environmental factors (e.g. parental smoking, parental cough, socioeconomic level, housing, and gas cooking) might also affect respiratory health, and thus confound any potential relationships between health and air pollution. The questionnaire also collected information on many of these confounding factors. For the purposes of initial analysis, the city was divided into five areas in which differences in air quality were expected. In general, factors which have been associated with poor respiratory health were observed to be more prevalent in areas of poorer air quality.

  1. Respiratory health effects of the indoor environment in a population of Dutch children

    SciTech Connect (OSTI)

    Dijkstra, L.; Houthuijs, D.; Brunekreef, B.; Akkerman, I.; Boleij, J.S. (Univ. of Wageningen (Netherlands))

    1990-11-01T23:59:59.000Z

    The effect of indoor exposure to nitrogen dioxide on respiratory health was studied over a period of 2 yr in a population of nonsmoking Dutch children 6 to 12 yr of age. Lung function was measured at the schools, and information on respiratory symptoms was collected from a self-administered questionnaire completed by the parents of the children. Nitrogen dioxide was measured in the homes of all children with Palmes' diffusion tubes. In addition, information on smoking and dampness in the home was collected by questionnaire. There was no relationship between exposure to nitrogen dioxide in the home and respiratory symptoms. Respiratory symptoms were found to be associated with exposure to tobacco smoke and home dampness. There was a weak, negative association between maximal midexpiratory flow (MMEF) and exposure to nitrogen dioxide. FEV1, peak expiratory flow, and MMEF were all negatively associated with exposure to tobacco smoke. Home dampness was not associated with pulmonary function. Lung function growth, measured over a period of 2 yr, was not consistently associated with any of the indoor exposure variables. The development of respiratory symptoms over time was not associated with indoor exposure to nitrogen dioxide. There was a significant association between exposure to environmental tobacco smoke in the home and the development of wheeze. There was also a significant association between home dampness and the development of cough.

  2. Inside Alzheimer's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reveal conditions that lead to the disease's signature tangles and plaques in the brain March 12, 2015 Inside Alzheimer's Disease Neuron membrane disruption may underlie...

  3. Cumulative exposure to arsenic and its relationship to respiratory cancer among copper-smelter employees

    SciTech Connect (OSTI)

    Lee-Feldstein, A.

    1986-01-01T23:59:59.000Z

    To explore the role of arsenic as a human carcinogen, the respiratory cancer-mortality experience (1938 to 1977) of 8045 white-male smelter employees in Montana was examined relative to cumulative exposure to arsenic trioxide and was compared with that of the white male population of the same region. Exposure to arsenic was estimated for various work areas from industrial-hygiene reports of average concentrations present in the smelter. Respiratory cancer mortality was analyzed further by time period of first employment and maximum lifetime exposure to arsenic trioxide. When exposure was estimated with arithmetic means of measured concentrations among men first employed prior to 1925, respiratory cancer mortality increased linearly with increasing cumulative exposure group, ranging from two to nine times expected; among those first employed in the period 1925 to 1947 it also increased linearly with increasing cumulative exposure group.

  4. Cumulative exposure to arsenic and its relationship to respiratory cancer among copper smelter employees

    SciTech Connect (OSTI)

    Lee-Feldstein, A.

    1986-04-01T23:59:59.000Z

    To explore the role of arsenic as a human carcinogen, the respiratory cancer mortality experience (1938 to 1977) of 8,045 while male smelter employees in Montana was examined relative to cumulative exposure to arsenic trioxide and was compared with that of the white male population of the same region. Exposure to arsenic was estimated for various work areas from industrial hygiene reports of average concentrations present in the smelter. Respiratory cancer mortality was analyzed further by time period of first employment and maximum lifetime exposure to arsenic trioxide. When exposure was estimated with arithmetic means of measured concentrations among men first employed prior to 1925, respiratory cancer mortality increased linearly with increasing cumulative exposure group, ranging from two to nine times expected; among those first employed in the period 1925 to 1947 it also increased linearly with increasing cumulative exposure group.

  5. Respiratory Oxygen Uptake Is Not Decreased by an Instantaneous Elevation of [CO2], But Is Increased with

    E-Print Network [OSTI]

    DeLucia, Evan H.

    of a high-resolution dual channel oxygen analyzer within an open gas exchange system to measure respiratoryRespiratory Oxygen Uptake Is Not Decreased by an Instantaneous Elevation of [CO2], But Is Increased an instantaneous reduction of leaf dark respiration measured as CO2 efflux. No known mechanism accounts

  6. Molecular Bioinformatics for Diseases

    E-Print Network [OSTI]

    Radivojac, Predrag

    . Curr Opin Pediatr, 13: 22 (2001). Leads to sickle cell anemia Manifestation of disease vastly different

  7. Kidney Disease of Diabetes

    E-Print Network [OSTI]

    Baker, Chris I.

    Kidney Disease of Diabetes National Kidney and Urologic Diseases Information Clearinghouse is the final stage of chronic kidney disease (CKD). Diabetes is the most common cause of kidney failure, accounting for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD

  8. Smoking cessation among coal miners as predicted by baseline respiratory function and symptoms: a 5-year prospective study

    SciTech Connect (OSTI)

    Ames, R.G.; Hall, D.S.

    1985-03-01T23:59:59.000Z

    A prospective analysis was used to test whether respiratory impairment or the presence of respiratory symptoms predicts 5-year cigarette smoking cessation in a sample of 1,118 U.S. white, male, underground coal miners. Miners were examined in 1977 and re-examined in 1982 by NIOSH, and all miners with test abnormalities were so informed by letter. Respiratory impairment was measured by an index of airways obstruction combining the spirometric measures of Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 sec (FEV1). Bronchitis symptoms were measured by an index that combined chronic cough (3+ months/year) and chronic phlegm (3 + months/year). Among these coal miners, the presence of chronic respiratory symptoms initially was inversely associated with cigarette smoking cessation. Respiratory impairment, however, was positively associated with cigarette smoking cessation but did not reach statistical significance.

  9. SU-D-17A-07: Development and Evaluation of a Prototype Ultrasonography Respiratory Monitoring System for 4DCT Reconstruction

    SciTech Connect (OSTI)

    Yan, P; Cheng, S; Chao, C [Columbia University Medical Center, NY, NY (United States); Jain, A [New York Presbyterian Hospital, NY, NY (United States)

    2014-06-01T23:59:59.000Z

    Purpose: Respiratory motion artifacts are commonly seen in the abdominal and thoracic CT images. A Real-time Position Management (RPM) system is integrated with CT simulator using abdominal surface as a surrogate for tracking the patient respiratory motion. The respiratory-correlated four-dimensional computed tomography (4DCT) is then reconstructed by GE advantage software. However, there are still artifacts due to inaccurate respiratory motion detecting and sorting methods. We developed an Ultrasonography Respiration Monitoring (URM) system which can directly monitor diaphragm motion to detect respiratory cycles. We also developed a new 4DCT sorting and motion estimation method to reduce the respiratory motion artifacts. The new 4DCT system was compared with RPM and the GE 4DCT system. Methods: Imaging from a GE CT scanner was simultaneously correlated with both the RPM and URM to detect respiratory motion. A radiation detector, Blackcat GM-10, recorded the X-ray on/off and synchronized with URM. The diaphragm images were acquired with Ultrasonix RP system. The respiratory wave was derived from diaphragm images and synchronized with CT scanner. A more precise peaks and valleys detection tool was developed and compared with RPM. The motion is estimated for the slices which are not in the predefined respiratory phases by using block matching and optical flow method. The CT slices were then sorted into different phases and reconstructed, compared with the images reconstructed from GE Advantage software using respiratory wave produced from RPM system. Results: The 4DCT images were reconstructed for eight patients. The discontinuity at the diaphragm level due to an inaccurate identification of phases by the RPM was significantly improved by URM system. Conclusion: Our URM 4DCT system was evaluated and compared with RPM and GE 4DCT system. The new system is user friendly and able to reduce motion artifacts. It also has the potential to monitor organ motion during therapy.

  10. Functional Analyses of the Molecular mechanisms Underlying Two Equine Respiratory Diseases: Recurrent Airway Obstruction and Rhodococcus equi Pneumonia

    E-Print Network [OSTI]

    Kachroo, Priyanka

    2012-07-16T23:59:59.000Z

    been implicated to have a role in asthma and RAO pathogenesis (Benamou et al., 1998; Granstrom et al., 2004; Venugopal et al., 2006; Kassuya et al., 2008). Endothelin-1 is involved in airway smooth muscle contraction, obstruction of bronchi, airway...

  11. Lung ventilation in vertebrates is accomplished by diverse respiratory pump mechanisms. Amniotes use an aspiration

    E-Print Network [OSTI]

    Brainerd, Elizabeth

    Lung ventilation in vertebrates is accomplished by diverse respiratory pump mechanisms. Amniotes primitive body form, and a recent study of lung ventilation in Necturus maculosus has suggested that studies). The mechanism of lung ventilation in N. maculosus is similar to the buccal pump used by lepidosirenid lungfishes

  12. Prevalence of respiratory symptoms and cases suspicious for tuberculosis among public health clinic patients in Afghanistan,

    E-Print Network [OSTI]

    Scharfstein, Daniel

    , and diagnostic test results were recorded. Correlates of TB-suggestive symptoms (defined as cough >2 weeks children (age 17 or under). The TB-suggestive symptoms of cough >2 weeks and / or haemoptysis were reported workers. keywords Afghanistan, tuberculosis, respiratory symptoms, cough, sputum smear accuracy

  13. Personal exposure to nitrogen dioxide and its association with respiratory illness in Hong Kong

    SciTech Connect (OSTI)

    Koo, L.C.; Ho, J.H.; Ho, C.Y.; Matsuki, H.; Shimizu, H.; Mori, T.; Tominaga, S. (Nam Long Hospital (Hong Kong))

    1990-05-01T23:59:59.000Z

    In 1985, 362 primary schoolchildren and their 319 mothers were surveyed in Hong Kong to study the possible relationship of air pollution to respiratory illnesses. Using nitrogen dioxide (NO{sub 2}) measured by personal samplers as a measure of air pollution, the study aimed to identify the major sources of NO{sub 2} in the indoor environment and see whether its increased presence was associated with respiratory symptoms. The levels of NO{sub 2} among the mothers was found to increase by 21% if dust exposure was reported from the workplace, 18% if they used such cooking fuels as liquid petroleum gas or kerosene, 11% when kitchens did not have ventilating fans, and 10% when incense was burned at home. In terms of respiratory symptoms, an increase in NO{sub 2} levels of 19% was reported among those with allergic rhinitis and 18% among those with chronic cough. The levels of NO2 among children were correlated with levels measured in classrooms, all of which had opened windows so that the NO{sub 2} came from outdoors. No association was found between children's NO{sub 2} levels and respiratory symptoms. With the exception of smoking by the father and the children's NO{sub 2} levels, no association was found between smoking at home and NO{sub 2} levels.

  14. Pulmonary function and respiratory symptoms of school children exposed to ambient air pollution

    SciTech Connect (OSTI)

    Kim, Yoon Shin; Ko, Ung Ring [Hanyang Univ., Seoul (Korea, Republic of)

    1996-12-31T23:59:59.000Z

    This study was undertaken to evaluate the health effect of air pollution on pulmonary function and respiratory symptoms of Korean school children between 7 and 10 years of age during November 1995-January 1996. A standard respiratory symptom questionnaire was administered and spirometry was performed to examine pulmonary function of 121 children in an urban polluted area, Seoul, and of 119 children in non-polluted area, Sokcho, respectively. There was significant difference in the level of pulmonary function [forced expiratory volume in second (FEV{sub 1.0}) and forced vital capacity (FVC)] between exposed groups to polluted area and non-polluted area. Parental smoking was significantly related to respiratory symptoms of cough, phlegm, and the level of pulmonary function. The observed changes in FEV{sub 1.0} and FVC seemed to relate to home cooking fuel, not to respiratory symptoms. The additional longitudinal work that carefully monitors ambient and indoor air pollution and health effects data should be conducted to confirm these results.

  15. Evaluation of Fiber Bundle Rotation for Enhancing Gas Exchange in a Respiratory Assist Catheter

    E-Print Network [OSTI]

    Federspiel, William J.

    of a rotating densely packed bundle of hollow fiber membranes, water and blood gas exchange levels were the concept of an intravenous respiratory assist device, in which a bundle of hollow fiber membranes (HFMs short blind- ended HFMs along its length in a "bottle-brush" configura- tion.11­14 Our group first

  16. Rhythm sequence through the olfactory bulb layers during the time window of a respiratory cycle

    E-Print Network [OSTI]

    Roux, Stephane

    Rhythm sequence through the olfactory bulb layers during the time window of a respiratory cycle 07, France Keywords: LFP, olfactory bulb, oscillations, rat, synchronization Abstract The mammalian olfactory bulb is characterized by prominent oscillatory activity of its local ®eld potentials. Breathing

  17. Early respiratory dysfunction as a biomarker for epileptic encephalopathy. Katrien Jansen, MD1

    E-Print Network [OSTI]

    calculated and respiration was derived from the ECG signal. ECG-derived respiration (EDR) signals were. Results In time domain, the standard deviation of the EDR signal is significantly lower in patients respiratory rate. In frequency domain we analysed the mean power spectrum for the EDR. In patients with West

  18. ECG-Derived Respiration: Comparison and New Measures for Respiratory Variability

    E-Print Network [OSTI]

    During ECG recording, several methods can be applied to derive a respiratory signal from the ECG (EDR signal). In this paper 4 EDR methods, including ECG filtering, R and RS amplitude based techniques-derived respiration or EDR signals and arise from the movement of electrodes with respect to the heart during

  19. Theoretical evaluation on burn injury of human respiratory tract due to inhalation of

    E-Print Network [OSTI]

    Zhang, Jun

    at tissue temperature (kPa) mQ Metabolic rate of tissue (W/m3 ) R Ideal gas constant (J/molK) Re Reynolds1 Theoretical evaluation on burn injury of human respiratory tract due to inhalation of hot gas to predict the thermal impact of inhaled hot air during the early stage of fires. Influences of individual

  20. Techniques in Whole Animal Respiratory Physiology JJ Cech Jr., University of California, Davis, CA, USA

    E-Print Network [OSTI]

    Wood, Spencer

    influenced by environmental temperature and so it is not always constant within an individual. Swimming The pressure that a component of a gas mixture would have if it alone occupied the same volume at the same The movement of the respiratory medium (air or water) over the surface of the gas exchanger. Ventilation volume

  1. Modeling Respiratory Lung Motion a Biophysical Approach using Finite Element Methods

    E-Print Network [OSTI]

    Lübeck, Universität zu

    Modeling Respiratory Lung Motion ­ a Biophysical Approach using Finite Element Methods Rene Wernera motion gains in importance. In this paper a biophysical approach for modeling lung motion is described. Main aspects of the process of lung ventilation are identified and outlined as the starting point

  2. Respiratory Organ Motion and Dosimetric Impact on Breast and Nodal Irradiation

    SciTech Connect (OSTI)

    Qi, X. Sharon, E-mail: xiangrong.qi@ucdenver.ed [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States); White, Julia [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Rabinovitch, Rachel [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States); Merrell, Kenneth; Sood, Amit; Bauer, Anderson; Wilson, J. Frank [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Miften, Moyed [Department of Radiation Oncology, University of Colorado Denver, Aurora, CO (United States); Li, X. Allen [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)

    2010-10-01T23:59:59.000Z

    Purpose: To examine the respiratory motion for target and normal structures during whole breast and nodal irradiation and the resulting dosimetric impact. Methods and Materials: Four-dimensional CT data sets of 18 patients with early-stage breast cancer were analyzed retrospectively. A three-dimensional conformal dosimetric plan designed to irradiate the breast was generated on the basis of CT images at 20% respiratory phase (reference phase). The reference plans were copied to other respiratory phases at 0% (end of inspiration) and 50% (end of expiration) to simulate the effects of breathing motion on whole breast irradiation. Dose-volume histograms, equivalent uniform dose, and normal tissue complication probability were evaluated and compared. Results: Organ motion of up to 8.8 mm was observed during free breathing. A large lung centroid movement was typically associated with a large shift of other organs. The variation of planning target volume coverage during a free breathing cycle is generally within 1%-5% (17 of 18 patients) compared with the reference plan. However, up to 28% of V{sub 45} variation for the internal mammary nodes was observed. Interphase mean dose variations of 2.2%, 1.2%, and 1.4% were observed for planning target volume, ipsilateral lung, and heart, respectively. Dose variations for the axillary nodes and brachial plexus were minimal. Conclusions: The doses delivered to the target and normal structures are different from the planned dose based on the reference phase. During normal breathing, the dosimetric impact of respiratory motion is clinically insignificant with the exception of internal mammary nodes. However, noticeable degradation in dosimetric plan quality may be expected for the patients with large respiratory motion.

  3. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08T23:59:59.000Z

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  4. A cross-sectional study of secondhand smoke exposure and respiratory symptoms in non-current smokers in the U.S. trucking industry: SHS exposure and respiratory symptoms

    E-Print Network [OSTI]

    Laden, Francine; Chiu, Yueh-Hsiu; Garshick, Eric; Hammond, S; Hart, Jaime E

    2013-01-01T23:59:59.000Z

    with chronic phlegm, chronic cough, and any wheeze, defined= 1.00- 2.13) for chronic cough, 1.55 (95% CI = 1.08-2.21)respiratory symptoms, including cough, phlegm and wheeze, in

  5. Cardiovascular Disease (CVD) Coronary heart disease

    E-Print Network [OSTI]

    Dever, Jennifer A.

    have a greater prevalence in women · Osteoporosis · Autoimmune disease A. Osteoporosis · Osteoporosis ­ disorder of low bone mass, microarchitectural denegra7on% of all women >65 years old have osteoporosis (15% of all Caucasian women

  6. Effect of nitroimidazoles on the oxygen consumption rate and respiratory control ratio of beef heart mitochondria

    SciTech Connect (OSTI)

    Chao, C.F.; Ting, L.; Subjeck, J.R.; Johnson, R.J.

    1984-08-01T23:59:59.000Z

    The neurotoxic effect of the nitroimidazole radiosensitizers misonidazole (MISO) and desmethylmisonidazole (DMM) has seriously compromised their clinical effectiveness. The authors compare here the effect of MISO and DMM on oxygen consumption in purified beef heart mitochondria. MISO has been found to significantly increase the oxygen consumption rate and decrease the respiratory control ratio in isolated mitochondria when incubated in the presence of the NAD+ dependent substrate, ..beta..-hydroxybutyrate. DMM has a similar but less pronounced effect than MISO on these respiratory parameters. When mitochondria were incubated in the presence of these radiosensitizers for 8, 15, 30, 45, and 60 minutes, the oxygen consumption rate was decreased when succinate, a FAD dependent substrate, was added following the incubation. This decrease, which is both time and dosage dependent, is equivalent for MISO and DMM.

  7. Respiratory symptoms and lung function in oil mist-exposed workers

    SciTech Connect (OSTI)

    Jarvholm, B. (Dept.of Occupational Medicine, Gothenburg, Sweden); Bake, B.; Lavenius, B.; Thiringer, G.; Vokmann, R.

    1982-06-01T23:59:59.000Z

    The prevalence of respiratory symptoms was registered and ventilatory function was determined in 164 men exposed to oil mist. The average exposure time was 16.2 years. One hundred fifty-nine office workers served as controls. The exposed men reported more respiratory symptoms: 14% of the exposed nonsmokers v. 2% of the nonsmoking controls having cough at least three months a year. There were non significant differences between spirometric measurements and chest roentgenograms of the men exposed to oil mist and those of the office workers. The lung function of 25 nonsmoking exposed men was further examined with other lung function tests. The mean values for closing volume, slope of the alveolar plateau, total lung capacity, residual volume, elastic recoil at various lung volumes, and diffusion capacity did not differ significantly.

  8. Respiratory survey of North American Indian children living in proximity to an aluminum smelter

    SciTech Connect (OSTI)

    Ernst, P.; Thomas, D.; Becklake, M.R.

    1986-02-01T23:59:59.000Z

    We explored the relationship of respiratory symptoms and lung function to exposure to ambient air pollution consisting of particulate and gaseous fluorides. The subjects were 253 North American Indian children 11 to 17 yr of age living on the Akwasasne reserve, which is adjacent to an aluminum smelter. Among boys, closing volume (CV/VC%) was increased in those raised closest to the smelter as opposed to those having lived most of their lives farthest from this source of air pollution. In both sexes, there was a significant linear relationship between increasing CV/VC% and the amount of fluoride contained in a spot urine sample. We conclude that exposure to fluoride air pollution in the community may be associated with abnormalities in small airways. The implication of these abnormalities for future respiratory health is unknown.

  9. A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus

    E-Print Network [OSTI]

    Chung, Dong-Hoon; Moore, Blake P.; Matharu, Daljit S.; Golden, Jennifer E.; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I.; Ananthan, Subramaniam; White, E. Lucile; Jia, Fuli; Jonsson, Colleen B.; Severson, William E.

    2013-01-10T23:59:59.000Z

    Background: Human respiratory syncytial virus (hRSV) is a highly contagious pathogen and is the most common cause of bronchiolitis and pneumonia for infants and children under one year of age. Worldwide, greater than 33 ...

  10. The role of vascular endothelial growth factor (VEGF) in repair and recovery from acute respiratory distress syndrome (ARDS) 

    E-Print Network [OSTI]

    Medford, Andrew R.L

    2007-01-01T23:59:59.000Z

    Acute Respiratory Distress Syndrome (ARDS) is the most extreme form of acute lung injury and continues to have a significant morbidity and mortality. Unfortunately, the mechanisms involved in the recovery and repair of ...

  11. Comments on the EPA/NIOSH guide to respiratory protection in the asbestos abatement industry

    SciTech Connect (OSTI)

    Hack, A.L.

    1987-01-01T23:59:59.000Z

    The respirators recommended by EPA and NIOSH for asbestos are not only extreme and impractical, but more important, unlikely to provide the highest protection possible. Because of the ease of wearing, powered air purifying respirators may provide as good protection as air line devices with fewer interruptions. Placing carcinogens in the category of compounds that are considered immediately dangerous to life and health (IDLH) is a mistake and leads to error in the selection of respiratory protection.

  12. The Department of Energy Respiratory Acceptance Program for Supplied-Air Suits

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-02-04T23:59:59.000Z

    The supplied-air suits that protect DOE contractor and federal employees from exposure to harmful atmospheres and radioactive contaminants are not included in the National Institute for Occupational Safety and Health (NIOSH) certification process for respiratory protective devices. Therefore, with the awareness and acknowledgement of NIOSH and the Occupational Safety and Health Administration (OSHA), the Department established a system for acceptance testing of supplied-air suits.

  13. Respiratory health effects associated with ambient sulfates and ozone in two rural Canadian communities

    SciTech Connect (OSTI)

    Stern, B.; Jones, L.; Raizenne, M.; Burnett, R.; Meranger, J.C.; Franklin, C.A.

    1989-06-01T23:59:59.000Z

    A cross-sectional epidemiological study investigating the respiratory health of children in two Canadian communities was conducted in 1983-1984 in Tillsonburg, Ontario, located in a region of moderately elevated concentrations of transported air pollutants, and in Portage la Prairie, Manitoba, situated in a low pollution area. There were no significant local sources of industrial emissions in either community. Seven hundred and thirty-five children aged 7-12 were studied in the first town and 895 in the second. Respiratory health was assessed by the measurement of the forced vital capacity (FVC) and forced expiratory volume in 1 sec (FEV1.0) of each child, and by evaluation of the child's respiratory symptoms and illnesses using a parent-completed questionnaire. Sulfur dioxide (SO2), sulfate, and particulate nitrate levels were significantly higher in Tillsonburg than in Portage la Prairie (P less than 0.05), but nitrogen dioxide (NO2) and inhalable particles (PM10) differed little between the communities. Historical data in the vicinity of Tillsonburg indicated that average annual levels of sulfates, total nitrates, and ozone (O3) did not vary markedly in the 9-year period preceding the study. The results show that Tillsonburg children had statistically significant (P less than 0.001) lower levels of 2% for FVC and 1.7% for FEV1.0 as compared with children in Portage la Prairie. These differences could not be explained by parental smoking or education, the use of gas cooking or wood heating fuels, pollution levels on the day of testing, or differences in age, sex, height, or weight. With the exception of inhalant allergies, which occurred more frequently in Tillsonburg children, the prevalence of chronic respiratory symptoms and illnesses was similar in the two communities.

  14. Rapid Reagentless Detection of M. tuberculosis H37Ra in Respiratory Effluents

    SciTech Connect (OSTI)

    Adams, K L; Steele, P T; Bogan, M J; Sadler, N M; Martin, S; Martin, A N; Frank, M

    2008-01-29T23:59:59.000Z

    Two similar mycobacteria, Mycobacteria tuberculosis H37Ra and Mycobacteria smegmatis are rapidly detected and identified within samples containing a complex background of respiratory effluents using Single Particle Aerosol Mass Spectrometry (SPAMS). M. tuberculosis H37Ra (TBa), an avirulent strain, is used as a surrogate for virulent tuberculosis (TBv); M. smegmatis (MSm) is utilized as a near neighbor confounder for TBa. Bovine lung surfactant and human exhaled breath condensate are used as first-order surrogates for infected human lung expirations from patients with pulmonary tuberculosis. This simulated background sputum is mixed with TBa or MSm and nebulized to produce conglomerate aerosol particles, single particles that contain a bacterium embedded within a background respiratory matrix. Mass spectra of single conglomerate particles exhibit ions associated with both respiratory effluents and mycobacteria. Spectral features distinguishing TBa from MSm in pure and conglomerate particles are shown. SPAMS pattern matching alarm algorithms are able to distinguish TBa containing particles from background matrix and MSm for >50% of the test particles, which is sufficient to enable a high probability of detection and a low false alarm rate if an adequate number of such particles are present. These results indicate the potential usefulness of SPAMS for rapid, reagentless tuberculosis screening.

  15. SU-E-J-261: Statistical Analysis and Chaotic Dynamics of Respiratory Signal of Patients in BodyFix

    SciTech Connect (OSTI)

    Michalski, D; Huq, M; Bednarz, G; Lalonde, R; Yang, Y; Heron, D [University of Pittsburgh Medical Center, Pittsburgh, PA (United States)

    2014-06-01T23:59:59.000Z

    Purpose: To quantify respiratory signal of patients in BodyFix undergoing 4DCT scan with and without immobilization cover. Methods: 20 pairs of respiratory tracks recorded with RPM system during 4DCT scan were analyzed. Descriptive statistic was applied to selected parameters of exhale-inhale decomposition. Standardized signals were used with the delay method to build orbits in embedded space. Nonlinear behavior was tested with surrogate data. Sample entropy SE, Lempel-Ziv complexity LZC and the largest Lyapunov exponents LLE were compared. Results: Statistical tests show difference between scans for inspiration time and its variability, which is bigger for scans without cover. The same is for variability of the end of exhalation and inhalation. Other parameters fail to show the difference. For both scans respiratory signals show determinism and nonlinear stationarity. Statistical test on surrogate data reveals their nonlinearity. LLEs show signals chaotic nature and its correlation with breathing period and its embedding delay time. SE, LZC and LLE measure respiratory signal complexity. Nonlinear characteristics do not differ between scans. Conclusion: Contrary to expectation cover applied to patients in BodyFix appears to have limited effect on signal parameters. Analysis based on trajectories of delay vectors shows respiratory system nonlinear character and its sensitive dependence on initial conditions. Reproducibility of respiratory signal can be evaluated with measures of signal complexity and its predictability window. Longer respiratory period is conducive for signal reproducibility as shown by these gauges. Statistical independence of the exhale and inhale times is also supported by the magnitude of LLE. The nonlinear parameters seem more appropriate to gauge respiratory signal complexity since its deterministic chaotic nature. It contrasts with measures based on harmonic analysis that are blind for nonlinear features. Dynamics of breathing, so crucial for 4D-based clinical technologies, can be better controlled if nonlinear-based methodology, which reflects respiration characteristic, is applied. Funding provided by Varian Medical Systems via Investigator Initiated Research Project.

  16. Development of a novel orthopedic microfastener

    E-Print Network [OSTI]

    Agnihotri, Mukul Mukund

    2007-04-25T23:59:59.000Z

    Varadharajan and Mr. Mitul Kothari for making this endeavor a memorable one. vi TABLE OF CONTENTS Page ABSTRACT?????????????????????????... iii DEDICATION????????????????????????.. iv ACKNOWLEDGMENTS...???????????????????..... v TABLE OF CONTENTS????????????????????.. vi LIST OF FIGURES??????????????????????... viii LIST OF TABLES??????????????????????..... xi LIST OF SYMBOLS?????????????????????..... xii CHAPTER I INTRODUCTION...

  17. Orthopedic Correction of Growing Retrognathic Hyperdivergent Patients

    E-Print Network [OSTI]

    Carrillo, Roberto

    2014-05-13T23:59:59.000Z

    The purpose of this prospective study was to determine whether dental intrusion is effective in treating growing retrognathic hyperdivergent patients without negatively affecting the roots and periodontal structures. The sample consisted of 17 (7...

  18. Air pollution and childhood respiratory health: Exposure to sulfate and ozone in 10 Canadian Rural Communities

    SciTech Connect (OSTI)

    Stern, B.R.; Raizenne, M.E.; Burnett, R.T.; Jones, L.; Kearney, J.; Franklin, C.A. (Environmental Health Directorate, Ottawa, Ontario (Canada))

    1994-08-01T23:59:59.000Z

    This study was designed to examine differences in the respiratory health status of preadolescent school children, aged 7-11 years, who resided in 10 rural Canadian communities in areas of moderate and low exposure to regional sulfate and ozone pollution. Five of the communities were located in central Saskatchewan, a low-exposure region, and five were located in southwestern Ontario, an area with moderately elevated exposures resulting from long-range atmospheric transport of polluted air masses. In this cross-sectional study, the child's respiratory symptoms and illness history were evaluated using a parent-completed questionnaire, administered in September 1985. Respiratory function was assessed once for each child in the schools between October 1985 and March 1986, by the measurement of pulmonary function for forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV[sub 1.0]), peak expiratory flow rate (PEFR), mean forced expiratory flow rate during the middle half of the FVC curve (FEF[sub 25-75]), and maximal expiratory flow at 50% of the expired vital capacity (V[sub 50]max). After controlling for the effects of age, sex, parental smoking, parental education and gas cooking, no significant regional differences were observed in rates of chronic cough or phlegm, persistent wheeze, current asthma, bronchitis in the past year, or any chest illness that kept the child at home for 3 or more consecutive days during the previous year. Children living in southwestern Ontario had statistically significant (P < 0.01) mean decrements of 1.7% in FVC and 1.3% in FEV[sub 1.0] compared with Saskatchewan children, after adjusting for age, sex, weight, standing height, parental smoking, and gas cooking. There were no statistically significant regional differences in the pulmonary flow parameters (P > 0.05). 54 refs., 1 fig., 7 tabs.

  19. Coal home heating and environmental tobacco smoke in relation to lower respiratory illness in Czech children, from birth to 3 years of age

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    still com- monly used in home heating and smoking rates arefound exposure to coal home heating and ETS increase youngcigarette smoke, coal heating, and respiratory symptoms of

  20. Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    with established acute lung injury. Respiratory Researchof patients with acute lung injury. Predictors of mortality.of mortality in acute lung injury during the era of lung

  1. Dosimetric evaluation of the interplay effect in respiratory-gated RapidArc radiation therapy

    SciTech Connect (OSTI)

    Riley, Craig [Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 (United States)] [Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 (United States); Yang, Yong, E-mail: yangy2@upmc.edu; Li, Tianfang; Zhang, Yongqian; Heron, Dwight E.; Huq, M. Saiful [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232 (United States)] [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232 (United States)

    2014-01-15T23:59:59.000Z

    Purpose: Volumetric modulated arc therapy (VMAT) with gating capability has had increasing adoption in many clinics in the United States. In this new technique, dose rate, gantry rotation speed, and the leaf motion speed of multileaf collimators (MLCs) are modulated dynamically during gated beam delivery to achieve highly conformal dose coverage of the target and normal tissue sparing. Compared with the traditional gated intensity-modulated radiation therapy technique, this complicated beam delivery technique may result in larger dose errors due to the intrafraction tumor motion. The purpose of this work is to evaluate the dosimetric influence of the interplay effect for the respiration-gated VMAT technique (RapidArc, Varian Medical Systems, Palo Alto, CA). Our work consisted of two parts: (1) Investigate the interplay effect for different target residual errors during gated RapidArc delivery using a one-dimensional moving phantom capable of producing stable sinusoidal movement; (2) Evaluate the dosimetric influence in ten clinical patients’ treatment plans using a moving phantom driven with a patient-specific respiratory curve. Methods: For the first part of this study, four plans were created with a spherical target for varying residual motion of 0.25, 0.5, 0.75, and 1.0 cm. Appropriate gating windows were applied for each. The dosimetric effect was evaluated using EDR2 film by comparing the gated delivery with static delivery. For the second part of the project, ten gated lung stereotactic body radiotherapy cases were selected and reoptimized to be delivered by the gated RapidArc technique. These plans were delivered to a phantom, and again the gated treatments were compared to static deliveries by the same methods. Results: For regular sinusoidal motion, the dose delivered to the target was not substantially affected by the gating windows when evaluated with the gamma statistics, suggesting the interplay effect has a small role in respiratory-gated RapidArc therapy. Varied results were seen when gated therapy was performed on the patient plans that could only be attributed to differences in patient respiratory patterns. Patients whose plans had the largest percentage of pixels failing the gamma statistics exhibited irregular breathing patterns including substantial interpatient variation in depth of respiration. Conclusions: The interplay effect has a limited impact on gated RapidArc therapy when evaluated with a linear phantom. Variations in patient breathing patterns, however, are of much greater clinical significance. Caution must be taken when evaluating patients’ respiratory efforts for gated arc therapy.

  2. Respiratory response of the sea anemone Bunodosoma cavernata (Bosc) to changes in temperature and salinity

    E-Print Network [OSTI]

    Retzer, Kent Arnold

    1985-01-01T23:59:59.000Z

    of Respiratory Rate . 6 2 Analysis of Variance Procedure for 0-2 Hour Average. . . 12 3 Analysis of Variance Procedure for 30 Minutes 13 Duncan's Multiple Range Test for 30 Minutes and 0-2 Hour Average and Acclimation Temperature 5 Duncan's Multiple Range... Test for 30 Minutes and 0-2 Hour Average and Experimental Temperature . 15 16 6 Duncan's Multiple Range Test for 30 Minutes and 0-2 Hour Average and Experimental Salinity 17 7 Duncan's Multiple Range Test for 30 Minutes and 0-2 Hour Average...

  3. Discriminant analysis of heart valve sounds during respiratory static volume conditions

    E-Print Network [OSTI]

    Hatzopoulos, Stavros D.

    1988-01-01T23:59:59.000Z

    oscilloscope. The respiration data was used as a marker of the subject's respiratory status and was only displayed on a 5111A TEKTRONIX oscilloscope. 88, . i. i ZZ33 46: Rr, , ii, 3'3l'0, '8z i i ZZ$3448 . :::-:-;. 8. 4. ::8i':888'88. '. . . . ::=. ::88... 100 points further. For this study the highest acceptable heart rate was set at 32 130 beats/min. This rate corresponded to a "R-R" repeti- tion of every 110 points. The detected "QRS" points were screened in two ways. First, a QRS point had...

  4. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25T23:59:59.000Z

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  5. Chronic Conditions and Disease Prevention

    E-Print Network [OSTI]

    , diabetes, heart disease and osteoarthritis. One-on-One Nutrition Counseling Help with weight management and supportive program for those who have chronic diseases such as diabetes, heart disease, stroke, arthritis

  6. Large scale disease prediction

    E-Print Network [OSTI]

    Schmid, Patrick R. (Patrick Raphael)

    2008-01-01T23:59:59.000Z

    The objective of this thesis is to present the foundation of an automated large-scale disease prediction system. Unlike previous work that has typically focused on a small self-contained dataset, we explore the possibility ...

  7. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  8. Feasibility of Respiratory Triggering for MR-Guided Microwave Ablation of Liver Tumors Under General Anesthesia

    SciTech Connect (OSTI)

    Morikawa, Shigehiro, E-mail: morikawa@belle.shiga-med.ac.jp; Inubushi, Toshiro [Shiga University of Medical Science, Seta Tsukinowa-cho, Ohtsu, Molecular Neuroscience Research Center (Japan); Kurumi, Yoshimasa; Naka, Shigeyuki; Sato, Koichiro; Demura, Koichi; Tani, Tohru [Shiga University of Medical Science, Department of Surgery (Japan); Haque, Hasnine A [GE-Yokogawa Medical Systems (Japan)

    2004-08-15T23:59:59.000Z

    We obtained clear and reproducible MR fluoroscopic images and temperature maps for MR image-guided microwave ablation of liver tumors under general anesthesia without suspending the artificial ventilation. Respiratory information was directly obtained from air-way pressure without a sensor on the chest wall. The trigger signal started scanning of one whole image with a spoiled gradient echo sequence. The delay time before the start of scanning was adjusted to acquire the data corresponding to the k-space center at the maximal expiratory phase. The triggered images were apparently clearer than the nontriggered ones and the location of the liver was consistent, which made targeting of the tumor easy. MR temperature images, which were highly susceptible to the movement of the liver, during microwave ablation using a proton resonance frequency method, could be obtained without suspending the artificial ventilation. Respiratory triggering technique was found to be useful for MR fluoroscopic images and MR temperature monitoring in MR-guided microwave ablation of liver tumors under general anesthesia.

  9. Respiratory responses of vigorously exercising children to 0. 12 ppm ozone exposure

    SciTech Connect (OSTI)

    McDonnell, W.F. 3d.; Chapman, R.S.; Leigh, M.W.; Strope, G.L.; Collier, A.M.

    1985-10-01T23:59:59.000Z

    Changes in respiratory function have been suggested for children exposed to less than 0.12 ppm ozone (O3) while engaged in normal activities. Because the results of these studies have been confounded by other variables, such as temperature or the presence of other pollutants or have been questioned as to the adequacy of exposure measurements, the authors determined the acute response of children exposed to 0.12 ppm O3 in a controlled chamber environment. Twenty-three white males 8 to 11 yr of age were exposed once to clean air and once to 0.12 ppm O3 in random order. Exposures were for 2.5 h and included 2 h of intermittent heavy exercise. Measures of forced expiratory volume in one second (FEV1) and the symptom cough were determined prior to and after each exposure. A significant decline in FEV1 was found after the O3 exposure compared to the air exposure, and it appeared to persist for 16 to 20 h. No significant increase in cough was found due to O3 exposure. Forced vital capacity, specific airways resistance, respiratory frequency, tidal volume, and other symptoms were measured in a secondary exploratory analysis of this study.

  10. Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children

    SciTech Connect (OSTI)

    Neas, L.M.; Dockery, D.W.; Ware, J.H.; Spengler, J.D.; Speizer, F.E.; Ferris, B.G. Jr. (Harvard School of Public Health, Boston, MA (USA))

    1991-07-15T23:59:59.000Z

    The effect of indoor nitrogen dioxide on the cumulative incidence of respiratory symptoms and pulmonary function level was studied in a cohort of 1,567 white children aged 7-11 years examined in six US cities from 1983 through 1988. Week-long measurements of nitrogen dioxide were obtained at three indoor locations over 2 consecutive weeks in both the winter and the summer months. The household annual average nitrogen dioxide concentration was modeled as a continuous variable and as four ordered categories. Multiple logistic regression analysis of symptom reports from a questionnaire administered after indoor monitoring showed that a 15-ppb increase in the household annual nitrogen dioxide mean was associated with an increased cumulative incidence of lower respiratory symptoms (odds ratio (OR) = 1.4, 95% confidence interval (95% Cl) 1.1-1.7). The response variable indicated the report of one or more of the following symptoms: attacks of shortness of breath with wheeze, chronic wheeze, chronic cough, chronic phlegm, or bronchitis. Girls showed a stronger association (OR = 1.7, 95% Cl 1.3-2.2) than did boys (OR = 1.2, 95% Cl 0.9-1.5). An analysis of pulmonary function measurements showed no consistent effect of nitrogen dioxide. These results are consistent with earlier reports based on categorical indicators of household nitrogen dioxide sources and provide a more specific association with nitrogen dioxide as measured in children's homes.

  11. Respiratory symptoms among glass bottle makers exposed to stannic chloride solution and other potentially hazardous substances

    SciTech Connect (OSTI)

    Levy, B.S.; Davis, F.; Johnson, B.

    1985-04-01T23:59:59.000Z

    Concern about upper respiratory tract irritation and other symptoms among workers at a glass bottle manufacturing plant led to an epidemiologic and an industrial hygiene survey. Questionnaire responses from 35 hot end and 53 cold end workers indicated that the incidence of wheezing, chest pain, dyspnea on exertion, and cough was significantly elevated among hot end workers. Among both smokers and nonsmokers, hot end workers reported higher, but not significantly higher, rates of wheezing and chest pain. Among smokers, hot end workers reported significantly higher rates of dyspnea on exertion and cough than did cold end workers. Data suggest that reported exposure to stannic chloride solution likely caused these symptoms. The industrial hygiene survey, conducted when stannic chloride use had been reduced, cleaning had been done, and ventilation improved, focused on measuring air contaminants that might possibly cause symptoms. Levels of hydrogen chloride, which apparently was formed by the combination of stannic chloride and water in the presence of heat, were elevated. The finding of increased prevalence of respiratory symptoms among hot end workers was consistent with this exposure. Recommendations were made to reduce hazardous exposures at this plant. Individuals responsible for occupational health should be aware that relatively benign substances, such as stannic chloride and water, can combine spontaneously to form hazardous substances.

  12. Absence of respiratory effects in subjects exposed to low concentrations of TDI and MDI

    SciTech Connect (OSTI)

    Musk, A.W.; Peters, J.M.; DiBerardinis, L.; Murphy, R.L.

    1982-10-01T23:59:59.000Z

    One hundred seven subjects from a polyurethane plastic manufacturing plant have been followed over a five-year period with measurements of forced expiratory volume in 1 s (FEV1), and questionnaires on respiratory symptoms and smoking habits. Environmental concentrations of toluene diisocyanate and diphenyl methyl diisocyanate were extensively monitored to provide accurate estimates of the upper-limits of exposure of the subjects. Current mean levels of FEV1 in this population were higher than those predicted for healthy subjects. The five-year change in FEV1 did not exceed that expected from aging. No acute change in FEV1 could be demonstrated over the course of a Monday either before or after a two-week vacation. No improvement in ventilatory function was observed over the vacation period. The presence of cough or sputum was related to smoking but was not related to isocyanate exposure. The results indicate that exposure of workers to extremely low levels of isocyanates (time-weighted average concentrations of the order of 0.001 parts per million (ppm)) is not associated with chronic respiratory symptoms or effects on ventilatory capacity. The results suggest that isocyanates can be controlled to the point of eliminating effects as measured by these techniques.

  13. Health effects of acid aerosols on North American children: Respiratory symptoms

    SciTech Connect (OSTI)

    Dockery, D.W. [Harvard School of Public Health, Boston, MA (United States)]|[Channing Lab., Boston, MA (United States); Cunningham, J.; Damokosh, A.I. [Harvard School of Public Health, Boston, MA (United States)] [and others

    1996-05-01T23:59:59.000Z

    We examined the respiratory health effects of exposure to acidic air pollution among 13,369 white children 8 to 12 years old from 24 communities in the United States and Canada between 1988 and 1991. Each child`s parent or guardian completed a questionnaire. Air quality and meteorology were measured in each community for a 1-year period. We used a two-stage logistic regression model to analyze the data, adjusting for the period confounding effects of sex, history of allergies, parental asthma, parental education, and current smoking in the home. Children living in the community with the highest levels of particle strong acidity were significantly more likely [odds ratio (OR) = 1.66; 95% confidence interval (CI) 1.11-2.48] to report at least one episode of bronchitis in the past year compared to children living in the least-polluted community. Fine particulate sulfate was also associated with higher reporting of bronchitis (OR = 1.65; 95% CI 1.12-2.42). No other respiratory symptoms were significantly higher in association with any of the air pollutants of interest. No sensitive subgroups were identified. Reported bronchitis, but neither asthma, wheeze, cough, nor phlegm, were associated with levels of particle strong acidity for these children living in a nonurban environment. 26 refs., 3 figs., 4 tabs.

  14. Use of dMLC for implementation of dynamic respiratory-gated radiation therapy

    SciTech Connect (OSTI)

    Pepin, Eric W.; Wu, Huanmei [Purdue School of Engineering Technology, IUPUI, Indianapolis, Indiana 46202 (United States)] [Purdue School of Engineering Technology, IUPUI, Indianapolis, Indiana 46202 (United States); Shirato, Hiroki [Hokkaido University School of Medicine, Sapporo 060-8638 (Japan)] [Hokkaido University School of Medicine, Sapporo 060-8638 (Japan)

    2013-10-15T23:59:59.000Z

    Purpose: To simulate and evaluate the use of dynamic multileaf collimators (dMLC) in respiratory gating to compensate for baseline drift.Methods: Tumor motion tracking data from 30 lung tumors over 322 treatment fractions was analyzed with the finite state model. A dynamic respiratory gating window was established in real-time by determining the average positions during the previous two end-of-expiration breathing phases and centering the dMLC aperture on a weighted average of these positions. A simulated dMLC with physical motion constraints was used in dynamic gating treatment simulations. Fluence maps were created to provide a statistical description of radiation delivery for each fraction. Duty cycle was also calculated for each fraction.Results: The average duty cycle was 2.3% greater under dynamic gating conditions. Dynamic gating also showed higher fluences and less tumor obstruction. Additionally, dynamic gating required fewer beam toggles and each delivery period was longer on average than with static gating.Conclusions: The use of dynamic gating showed better performance than static gating and the physical constraints of a dMLC were shown to not be an impediment to dynamic gating.

  15. Buffering blood pressure fluctuations by respiratory sinus arrhythmia may in fact enhance them: a theoretical analysis

    E-Print Network [OSTI]

    Teodor Buchner; Jan ?ebrowski; Grzegorz Gielerak

    2010-07-13T23:59:59.000Z

    Using a three-compartment model of blood pressure dynamics, we analyze theoretically the short term cardiovascular variability: how the respiratory-related blood pressure fluctuations are buffered by appropriate heart rate changes: i.e. the respiratory sinus arrhythmia. The buffering is shown to be crucially dependent on the time delay between the stimulus (such as e.g. the inspiration onset) and the application of the control (the moment in time when the efferent response is delivered to the heart). This theoretical analysis shows that the buffering mechanism is effective only in the upright position of the body. It explains a paradoxical effect of enhancement of the blood pressure fluctuations by an ineffective control. Such a phenomenon was observed experimentally. Using the basis of the model, we discuss the blood pressure variability and heart rate variability under such clinical conditions as the states of expressed adrenergic drive and the tilt-test during the parasympathetic blockade or fixed rate atrial pacing. From the results of the variability analysis we draw a conclusion that the control of blood pressure in the HF band does not directly obtain the arterial baroreceptor input. We also discuss methodological issues of baroreflex sensitivity and sympathovagal balance assessment.

  16. SU-E-J-45: Design and Study of An In-House Respiratory Gating Phantom Platform for Gated Radiotherapy

    SciTech Connect (OSTI)

    Senthilkumar, S [Madurai Medical College ' Govt. Rajaji Hospital, Madurai (India)

    2014-06-01T23:59:59.000Z

    Purpose: The main purpose of this work was to develop an in-house low cost respiratory motion phantom platform for testing the accuracy of the gated radiotherapy system and analyze the dosimetric difference during gated radiotherapy. Methods: An in-house respiratory motion platform(RMP) was designed and constructed for testing the targeting accuracy of respiratory tracking system. The RMP consist of acrylic Chest Wall Platform, 2 DC motors, 4 IR sensors, speed controller circuit, 2 LED and 2 moving rods inside the RMP. The velocity of the movement can be varied from 0 to 30 cycles per minute. The platform mounted to a base using precision linear bearings. The base and platform are made of clear, 15mm thick polycarbonate plastic and the linear ball bearings are oriented to restrict the platform to a movement of approximately 50mm up and down with very little friction. Results: The targeting accuracy of the respiratory tracking system was evaluated using phantom with and without respiratory movement with varied amplitude. We have found the 5% dose difference to the PTV during the movement in comparison with stable PTV. The RMP can perform sinusoidal motion in 1D with fixed peak to peak motion of 5 to 50mm and cycle interval from 2 to 6 seconds. The RMP was designed to be able to simulate the gross anatomical anterior posterior motion attributable to respiration-induced motion of the thoracic region. Conclusion: The unique RMP simulates breathing providing the means to create a comprehensive program for commissioning, training, quality assurance and dose verification of gated radiotherapy treatments. Create the anterior/posterior movement of a target over a 5 to 50 mm distance to replicate tumor movement. The targeting error of the respiratory tracking system is less than 1.0 mm which shows suitable for clinical treatment with highly performance.

  17. Periodontal Disease and Heart Health

    E-Print Network [OSTI]

    Goldman, Steven A.

    Periodontal Disease and Heart Health Deaf HealthTalks Presenter: Christopher Lehfeldt, DDS Elmwood #12;X-ray showing bone loss rickwilsondmd.typepad.com Thursday, March 15, 12 #12;5. What is heart disease? · The medical name for heart disease is cardiovascular disease (CVD) · An American dies from CVD

  18. Recent studies have demonstrated that limitations to oxygen transport in lizards occur within both the respiratory and

    E-Print Network [OSTI]

    Bennett, Albert F.

    both the respiratory and cardiovascular systems. The lateral flexions of the trunk that occur during this constraint by employing an accessory ventilatory mechanism called the gular pump, thus maintaining oxygen of the main veins in the abdominal compartment. Systemic venous return and ventricular preload are major

  19. Associations of symptoms related to isocyanate, ureaformol, and formophenolic exposures with respiratory symptoms and lung function in coal miners

    SciTech Connect (OSTI)

    Bertrand, J.P.; Simon, V.; Chau, N. [Houilleres Bassin Lorraine, Freyming Merlebach (France)

    2007-04-15T23:59:59.000Z

    The respiratory effects of diphenylmethane diisocyanate (MDI)-based resins and ureaformol- and formophenolic-based resins, used in coal mining, are unknown. This cross-sectional study of 354 miners evaluated respiratory health in miners with MDI-related symptoms (IS) and ureaformol/formophenolic-related symptoms (UFS). The protocol included clinical examination, chest radiograph, questionnaire on respiratory symptoms, smoking habit, job history, resin handling, and spirometry. Resin handling concerned 27.7% of the miners. IS affected 5.6%, and 1.4% also after work. UFS affected 22.6%, and 2.3% also after work. Wheezing affected 35.6%; chronic cough, expectoration, or bronchitis about 10%; dyspnea 5.4%; and asthma 2.8%. The miners with UFS had significantly more frequent chronic cough, expectoration, chronic bronchitis, dyspnea, and wheezing, whereas those with IS at and after work had markedly lower FVC, FEV1, MMEF, FEF50% and FEF25%. These findings raise the possibility of deleterious effects of exposures to MDI and ureaformol/ ormophenolic resins on respiratory health and lung function in coal miners during their working life.

  20. Variations of the Respiration Signals for Respiratory-Gated Radiotherapy Using the Video Coached Respiration Guiding System

    E-Print Network [OSTI]

    Lee, Hyun Jeong; Oh, Se An

    2015-01-01T23:59:59.000Z

    Respiratory-gated radiation therapy (RGRT) has been used to minimize the dose to normal tissue in lung-cancer radiotherapy. The present research aims to improve the regularity of respiration in RGRT using a video coached respiration guiding system. In the study, 16 patients with lung cancer were evaluated. The respiration signals of the patients were measured by a real-time position management (RPM) Respiratory Gating System (Varian, USA) and the patients were trained using the video coached respiration guiding system. The patients performed free breathing and guided breathing, and the respiratory cycles were acquired for ~5 min. Then, Microsoft Excel 2010 software was used to calculate the mean and standard deviation for each phase. The standard deviation was computed in order to analyze the improvement in the respiratory regularity with respect to the period and displacement. The standard deviation of the guided breathing decreased to 65.14% in the inhale peak and 71.04% in the exhale peak compared with the...

  1. Incorporation of motion information for tumour volume definition in PET Comparison of different methods of incorporating respiratory

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , respiratory motion, super-resolution, 4D PET imaging 1. Introduction Computed tomography (CT) is routinely Tomography (PET) for diagnosis and staging, as well as the widespread availability of combined PET/CT scanners, led to numerous studies investigating the potential of PET/CT for target volume delineation. Use

  2. Effects of ambient ozone on respiratory function and symptoms in Mexico City schoolchildren

    SciTech Connect (OSTI)

    Castillejos, M.; Gold, D.R.; Dockery, D.; Tosteson, T.; Baum, T.; Speizer, F.E. (Universidad Autonoma Metropolitana-X, Mexico City, (Mexico))

    1992-02-01T23:59:59.000Z

    The effects of ambient ozone (O3) on respiratory function and acute respiratory symptoms were evaluated in 143 7- to 9-yr-old schoolchildren followed longitudinally at 1- to 2-wk intervals over a period of 6 months at three schools in Pedregal, Mexico City. The maximum O3 level exceeded the World Health Organization guideline of 80 ppb and the U.S. standard of 120 ppb in every week. For an increase from lowest to highest in the mean O3 level during the 48 hr before spirometry (53 ppb), logistic regression estimated relative odds of 1.7 for a child reporting cough/phlegm on the day of spirometry. For the full population, the mean O3 level during the hour before spirometry, not adjusted for temperature and humidity, predicted a significant decrement in FVC but not in FEV1 or FEF25-75. In contrast, the mean O3 level during the previous 24-, 48-, and 168-h periods predicted significant decrements in FEV1 and FEF25-75 but not in FVC. Ozone was consistently associated with a greater decrement in lung function for the 15 children with chronic phlegm as compared with the children without chronic cough, chronic phlegm, or wheeze. Ozone in the previous 24-, 48-, and 168-h periods predicted decrements in FEV1 for children of mothers who were current or former smokers, but not for children of mothers who were never smokers. Many of these effects were reduced in multiple regression analyses including temperature and humidity, as temperature and O3 were highly correlated.

  3. Meta-Analyses of the Associations of Respiratory Health Effectswith Dampness and Mold in Homes

    SciTech Connect (OSTI)

    Fisk, William J.; Lei-Gomez, Quanhong; Mendell, Mark J.

    2006-01-01T23:59:59.000Z

    The Institute of Medicine (IOM) of the National Academy of Sciences recently completed a critical review of the scientific literature pertaining to the association of indoor dampness and mold contamination with adverse health effects. In this paper, we report the results of quantitative meta-analysis of the studies reviewed in the IOM report. We developed point estimates and confidence intervals (CIs) to summarize the association of several respiratory and asthma-related health outcomes with the presence of dampness and mold in homes. The odds ratios and confidence intervals from the original studies were transformed to the log scale and random effect models were applied to the log odds ratios and their variance. Models were constructed both accounting for the correlation between multiple results within the studies analyzed and ignoring such potential correlation. Central estimates of ORs for the health outcomes ranged from 1.32 to 2.10, with most central estimates between 1.3 and 1.8. Confidence intervals (95%) excluded unity except in two of 28 instances, and in most cases the lower bound of the CI exceeded 1.2. In general, the two meta-analysis methods produced similar estimates for ORs and CIs. Based on the results of the meta-analyses, building dampness and mold are associated with approximately 30% to 80% increases in a variety of respiratory and asthma-related health outcomes. The results of these meta-analyses reinforce the IOM's recommendation that actions be taken to prevent and reduce building dampness problems.

  4. Effects of ambient sulfur oxides and suspended particles on respiratory health of preadolescent children

    SciTech Connect (OSTI)

    Ware, J.H.; Ferris, B.G. Jr.; Dockery, D.W.; Spengler, J.D.; Stram, D.O.; Speizer, F.E.

    1986-05-01T23:59:59.000Z

    Reported here are the results from an ongoing study of outdoor air pollution and respiratory health of children living in six cities in the eastern and midwestern United States. The study enrolled 10,106 white preadolescent children between 1974 and 1977 in 3 successive annual visits to each city. Each child received a spirometric examination, and a parent completed a standard questionnaire. Of this cohort, 8,380 children were seen for a second examination 1 yr later. An air pollution monitoring program was begun in each community at about the time of the first examination. For this report, measurements of total suspended particulates (TSP), the sulfate fraction of TSP (TSO/sub 4/), and sulfur dioxide (SO2) concentrations at study-affiliated outdoor stations were combined with measurements at other public and private monitoring sites to create a record of TSP, TSO/sub 4/, and SO/sub 2/ concentrations in each of 9 air pollution regions during the 1-yr period preceding each examination and, for TSP, during each child's lifetime up to the time of testing. Across the 6 cities, frequency of cough was significantly associated with the average of 24-h mean concentrations of all 3 air pollutants during the year preceding the health examination (p less than 0.01). Rates of bronchitis and a composite measure of lower respiratory illness were significantly associated with average particulate concentrations (p less than 0.05). In analyses restricted to lifetime residents, these outcomes were significantly associated with measures of lifetime mean TSP concentration. Within the cities, however, temporal and spatial variation in air pollutant concentrations and illness and symptom rates were not positively associated.

  5. Reproductive Diseases in Cattle

    E-Print Network [OSTI]

    Sprott, L. R.; Field, Bob

    1998-12-03T23:59:59.000Z

    susceptible. Droplets of urine from infected cows can infect normal cows after contact with the eye or mucous membranes of the nose or mouth. The disease infects more cattle each day, preventing cows from settling and lengthening their calving intervals... abortus) fetal membranes from aborting heifers at 4-12 not vaccinate bulls. cow; fetus; months. placenta Leptospirosis Bacterial (At least Urine of infected Any stage, Sample 10 Every 6 months Laboratory should deter- 5 serotypes) animals...

  6. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01T23:59:59.000Z

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  7. Elevated temperature triggers human respiratory syncytial virus F protein six-helix bundle formation

    SciTech Connect (OSTI)

    Yunus, Abdul S.; Jackson, Trent P.; Crisafi, Katherine; Burimski, Irina; Kilgore, Nicole R.; Zoumplis, Dorian; Allaway, Graham P.; Wild, Carl T. [Panacos Pharmaceuticals, Inc., 209 Perry Parkway, Suite 7, Gaithersburg, MD 20877 (United States); Salzwedel, Karl, E-mail: salzwedelkd@niaid.nih.go [Panacos Pharmaceuticals, Inc., 209 Perry Parkway, Suite 7, Gaithersburg, MD 20877 (United States)

    2010-01-20T23:59:59.000Z

    Human respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infection in infants, immunocompromised patients, and the elderly. The RSV fusion (F) protein mediates fusion of the viral envelope with the target cell membrane during virus entry and is a primary target for antiviral drug and vaccine development. The F protein contains two heptad repeat regions, HR1 and HR2. Peptides corresponding to these regions form a six-helix bundle structure that is thought to play a critical role in membrane fusion. However, characterization of six-helix bundle formation in native RSV F protein has been hindered by the fact that a trigger for F protein conformational change has yet to be identified. Here we demonstrate that RSV F protein on the surface of infected cells undergoes a conformational change following exposure to elevated temperature, resulting in the formation of the six-helix bundle structure. We first generated and characterized six-helix bundle-specific antibodies raised against recombinant peptides modeling the RSV F protein six-helix bundle structure. We then used these antibodies as probes to monitor RSV F protein six-helix bundle formation in response to a diverse array of potential triggers of conformational changes. We found that exposure of 'membrane-anchored' RSV F protein to elevated temperature (45-55 deg. C) was sufficient to trigger six-helix bundle formation. Antibody binding to the six-helix bundle conformation was detected by both flow cytometry and cell-surface immunoprecipitation of the RSV F protein. None of the other treatments, including interaction with a number of potential receptors, resulted in significant binding by six-helix bundle-specific antibodies. We conclude that native, untriggered RSV F protein exists in a metastable state that can be converted in vitro to the more stable, fusogenic six-helix bundle conformation by an increase in thermal energy. These findings help to better define the mechanism of RSV F-mediated membrane fusion and have important implications for the identification of therapeutic strategies and vaccines targeting RSV F protein conformational changes.

  8. Association between occupational exposure to arsenic and neurological, respiratory and renal effects

    SciTech Connect (OSTI)

    Halatek, Tadeusz [Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz (Poland)], E-mail: halatek@imp.lodz.pl; Sinczuk-Walczak, Halina [Outpatient Clinic of Occupational Disease, Nofer Institute of Occupational Medicine, Lodz (Poland); Rabieh, Sasan [Faculty of Biology, Chemistry, and Geosciences, University of Bayreuth, Bayreuth (Germany); Wasowicz, Wojciech [Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz (Poland)

    2009-09-01T23:59:59.000Z

    Occupational exposure by inhalation in copper smelter is associated with several subclinical health phenomena. The respiratory tract is usually involved in the process of detoxication of inhaled noxious agents which, as arsenic, can act as inductors of oxidative stress (Lantz, R.C., Hays, A.M., 2006. Role of oxidative stress in arsenic-induced toxicity. Drug Metab. Rev. 38, 791-804). It is also known that irritating fumes affect distal bronchioles of non-ciliated, epithelial Clara cells, which secrete anti-inflammatory and immunosuppressive Clara cell protein (CC16) into the respiratory tract. The study group comprised 39 smelters employed at different workplaces in a copper foundry, matched for age and smoking habits with the control group (n = 16). Subjective neurological symptoms (SNS), visual evoked potentials (VEP), electroneurographic (EneG) and electroencephalographic (EEG) results were examined in the workers and the relationships between As concentration in the air (As-Air) and urine (As-U) were assessed. Effects of exposure were expressed in terms of biomarkers: CC16 as early pulmonary biomarker and {beta}{sub 2}-microglobulin ({beta}{sub 2}M) in urine and serum and retinol binding protein (RBP) as renal markers, measured by sensitive latex immunoassay. The concentrations of arsenic exceeded about two times the Threshold Limit Values (TLV) (0.01 mg/m{sup 3}). The contents of lead did not exceed the TLV (0.05 mg/m{sup 3}). Low CC16 levels in serum (12.1 {mu}g/l) of workers with SNS and VEP symptoms and highest level As-U (x{sub a} 39.0 {mu}g/l) were noted earliest in relation to occupational time. Moreover, those effects were associated with increased levels of urinary and serum {beta}{sub 2}M and urinary RBP. Results of our study suggested the initiative key role of oxidative stress in triggering the processes that eventually lead to the subclinical effects of arsenic on the nervous system.

  9. Relationship of respiratory symptoms and pulmonary function to tar, nicotine, and carbon monoxide yield of cigarettes

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Sherrill, D.L.; Paoletti, P.; Lebowitz, M.D. (National Institute of Hygiene, Warsaw (Poland))

    1991-02-01T23:59:59.000Z

    The data from consecutive surveys of the Tucson Epidemiologic Study (1981-1988) were used to evaluate the relationship in cigarette smokers of respiratory symptoms and pulmonary function to tar, nicotine, and carbon monoxide (CO) yields of the cigarette. There were 690 subjects who reported smoking regularly in at least one survey, over age 15. After adjustment for intensity and duration of smoking and for depth of inhalation, the risk of chronic phlegm, cough, and dyspnea were not related to the tar and nicotine yields. In 414 subjects with pulmonary function tested in at least one of the three surveys the spirometric indices used were significantly related to the daily dose of tar, nicotine, and CO (product of the cigarette yield and daily number of cigarettes smoked). The effects were more pronounced for past than for current doses. However, the differentiation of pulmonary function due to various yields of cigarettes was small in comparison to the difference in pulmonary function between smokers and nonsmokers.

  10. Daily diaries of respiratory symptoms and air pollution: Methodological issues and results

    SciTech Connect (OSTI)

    Schwartz, J. (Environmental Protection Agency, Washington, DC (United States)); Wypij, D.; Dockery D.; Ware, J.; Spengler, J.; Ferris, B. Jr. (Harvard School of Public Health, Boston, MA (United States)); Zeger, S. (Johns Hopkins School of Hygiene and Public Health, Baltimore, MD (United States))

    1991-01-01T23:59:59.000Z

    Daily diaries of respiratory symptoms are a powerful technique for detecting acute effects of air pollution exposure. While conceptually simple, these diary studies can be difficult to analyze. The daily symptom rates are highly correlated, even after adjustment for covariates, and this lack of independence must be considered in the analysis. Possible approaches include the use of incidence instead of prevalence rates and autoregressive models. Heterogeneity among subjects also induces dependencies in the data. These can be addressed by stratification and by two-stage models such as those developed by Korn and Whittemore. These approaches have been applied to two data sets: a cohort of school children participating in the Harvard Six Cities Study and a cohort of student nurses in Los Angeles. Both data sets provide evidence of autocorrelation and heterogeneity. Controlling for autocorrelation corrects the precision estimates, and because diary data are usually positively autocorrelated, this leads to larger variance estimates. Controlling for heterogeneity among subjects appears to increase the effect sizes for air pollution exposure. Preliminary results indicate associations between sulfur dioxide and cough incidence in children and between nitrogen dioxide and phlegm incidence in student nurses.

  11. Spirometry variability criteria--association with respiratory morbidity and mortality in a cohort of coal miners

    SciTech Connect (OSTI)

    Kellie, S.E.; Attfield, M.D.; Hankinson, J.L.; Castellan, R.M.

    1987-03-01T23:59:59.000Z

    To clarify the association between spirometry variability and respiratory morbidity and mortality, the authors analyzed data for miners examined in the first round of the National Coal Study, 1969-1971, and they compared groups of miners who failed with those who met each of two spirometry variability criteria: a 5% criterion recommended by the American Thoracic Society, and a 200 ml criterion used in prior research studies. Compared with miners who met the 5% criterion (the best two forced vital capacities must be within 5% or 100 ml of one another), the group that failed had a lower mean for forced expiratory volume in one second (FEV1), and odds ratios for cough, phlegm, wheeze, shortness of breath, and death of 1.75, 1.67, 1.76, 2.71, and 1.30, respectively. The findings for the 200 ml criterion (the best two FEV1s must be within 200 ml of one another) were somewhat different. The group that failed versus the group that met this criterion had a higher mean for FEV1, and odds ratios for cough, phlegm, wheeze, shortness of breath, and death of 1.13, 1.07, 1.15, 1.43, and 0.94, respectively. Although the findings differ for the two criteria, the findings demonstrate that increased spirometry variability is associated with poorer health.

  12. The respiratory health and lung function of Anglo-American children in a smelter town

    SciTech Connect (OSTI)

    Dodge, R.

    1983-02-01T23:59:59.000Z

    Cooper smelters are large, usually isolated, sources of air pollution. Arizona has several such plants on the periphery of small communities. The smelters emit predominantly sulfur oxides and particulates, and the residents of these communities intermittently are exposed to high concentrations (24-h sulfur dioxide (SO2) . 250 to 500 micrograms/m3) of smelter smoke but little other pollution. This study compared the respiratory health of Anglo-American school children who lived in one smelter community with children living in another small community in Arizona that was free of smelter air pollution. The prevalence of cough, as determined by questionnaire, was 25.6% in the smelter town children and 14.3% in the nonsmelter town children (p less than 0.05). Pulmonary function at the study onset was equal in the two groups. Over the course of the 4 yr of study, lung function growth (measured as actual forced expiratory volume in one second (FEV1) after 4 yr of study minus predicted FEV1) was also equal in the smelter town and nonsmelter town children. These results suggest that children in smelter communities have slightly more cough when compared with children living in other communities, but no differences in initial lung function or lung function at yearly testing over the period of the study.

  13. Effect of diaphragmatic fatigue on control of the respiratory muscles during CO sub 2 rebreathing

    SciTech Connect (OSTI)

    Yan, S.; Lichros, I.; Macklem, P.T. (McGill Univ., Montreal, Quebec (Canada) Montreal Chest Hospital, Quebec (Canada))

    1991-03-11T23:59:59.000Z

    The authors measured respiratory muscle recruitment and ventilation ({dot V}{sub E}) during CO{sub 2} rebreathing before and after diaphragmatic fatigue in normal subjects. Muscle activity was assessed by measuring pleural, abdominal, and transdiaphragmatic pressures (Ppl, Pab, and Pdi, resp). The results showed that (1) there was a progressive increase in Pdi with increasing end-tidal PCO{sub 2} (P{sub ET}CO{sub 2}); the rate of increase was usually greater before than after fatigue, however, in some it was less because of longer operating length and/or passive stretching of the diaphragm due to strong rib cage muscle (RCM) activity induced by fatigue; (2) Pdi increased mainly due to greater fall in Ppl; {Delta}Pab increased little during CO{sub 2} rebreathing or even decreased with P{sub ET}CO{sub 2} over 50-55 mmHg; this pattern was exaggerated by fatigue; (3) at the end of each trial, the ratio {minus}{Delta}Ppl/{Delta}Pab increased by {approximately}140% before and {approximately}850% after fatigue; (4) CO{sub 2} induced expiratory abdominal muscle activity; and (5) as a group, {dot V}{sub E} and its pattern did not change appreciably with fatigue. The authors conclude that RCM are recruited proportionately more than the diaphragm by CO{sub 2} and that diaphragmatic fatigue shifts the central drive from the fatigued diaphragm to TCM to preserve ventilation.

  14. Epidemiological-environmental study of diesel bus garage workers: chronic effects of diesel exhaust on the respiratory system

    SciTech Connect (OSTI)

    Gamble, J.; Jones, W.; Minshall, S.

    1987-10-01T23:59:59.000Z

    Two hundred and eighty-three (283) male diesel bus garage workers from four garages in two cities were examined to determine if there was excess chronic respiratory morbidity related to diesel exposure. The dependent variables were respiratory symptoms, radiographic interpretation for pneumoconiosis, and pulmonary function (FVC, FEV1, and flow rates). Independent variables included race, age, smoking, drinking, height, and tenure (as surrogate measure of exposure). Exposure-effect relationships within the study population showed no detectable associations of symptoms with tenure. There was an apparent association of pulmonary function and tenure. Seven workers (2.5%) had category 1 pneumoconiosis (three rounded opacities, two irregular opacities, and one with both rounded and irregular). The study population was also compared to a nonexposed blue-collar population. After indirect adjustment for age, race, and smoking, the study population had elevated prevalences of cough, phlegm, and wheezing, but there was no association with tenure. Dyspnea showed a dose-response trend but no apparent increase in prevalence. Mean percent predicted pulmonary function of the study population was greater than 100%, i.e., elevated above the comparison population. These data show there is an apparent effect of diesel exhaust on pulmonary function but not chest radiographs. Respiratory symptoms are high compared to blue-collar workers, but there is no relationship with tenure.

  15. Patient-specific quantification of respiratory motion-induced dose uncertainty for step-and-shoot IMRT of lung cancer

    SciTech Connect (OSTI)

    Li, Heng; Park, Peter; Liu, Wei; Matney, Jason; Balter, Peter; Zhang, Xiaodong; Li, Xiaoqiang; Zhu, X. Ronald [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Liao, Zhongxing [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Li, Yupeng [Applied Research, Varian Medical Systems, Palo Alto, California 94304 (United States)] [Applied Research, Varian Medical Systems, Palo Alto, California 94304 (United States)

    2013-12-15T23:59:59.000Z

    Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique.Methods: Ten patients with stage II/III lung cancer who had undergone a planning four-dimensional (4D) computed tomographic scan and step-and-shoot IMRT planning were selected with a mix of motion and tumor size for this retrospective study. A step-and-shoot IMRT plan was generated for each patient. The maximum and minimum doses with respiratory motion were calculated for each plan, and the mean deviation from the 4D dose was calculated, taking delivery time, fractionation, and patient breathing cycle into consideration.Results: For all patients evaluated in this study, the mean deviation from the 4D dose in the planning target volume (PTV) was <2.5%, with a standard deviation <1.2%, and maximum point dose variation from the 4D dose was <6.2% in the PTV assuming delivery dose rate of 200 MU/min and patient breathing cycle of 8 s. The motion-induced dose uncertainty is a function of motion, fractionation, MU (plan modulation), dose rate, and patient breathing cycle.Conclusions: Respiratory motion-induced dose uncertainty varies from patient to patient. Therefore, it is important to evaluate the dose uncertainty on a patient-specific basis, which could be useful for plan evaluation and treatment strategy determination for selected patients.

  16. A multiplexed reverse transcriptase PCR assay for identification of viral respiratory pathogens at point-of-care

    SciTech Connect (OSTI)

    Letant, S E; .Ortiz, J I; Tammero, L; Birch, J M; Derlet, R W; Cohen, S; Manning, D; McBride, M T

    2007-04-11T23:59:59.000Z

    We have developed a nucleic acid-based assay that is rapid, sensitive, specific, and can be used for the simultaneous detection of 5 common human respiratory pathogens including influenza A, influenza B, parainfluenza type 1 and 3, respiratory syncytial virus, and adenovirus group B, C, and E. Typically, diagnosis on an un-extracted clinical sample can be provided in less than 3 hours, including sample collection, preparation, and processing, as well as data analysis. Such a multiplexed panel would enable rapid broad-spectrum pathogen testing on nasal swabs, and therefore allow implementation of infection control measures, and timely administration of antiviral therapies. This article presents a summary of the assay performance in terms of sensitivity and specificity. Limits of detection are provided for each targeted respiratory pathogen, and result comparisons are performed on clinical samples, our goal being to compare the sensitivity and specificity of the multiplexed assay to the combination of immunofluorescence and shell vial culture currently implemented at the UCDMC hospital. Overall, the use of the multiplexed RT-PCR assay reduced the rate of false negatives by 4% and reduced the rate of false positives by up to 10%. The assay correctly identified 99.3% of the clinical negatives, 97% of adenovirus, 95% of RSV, 92% of influenza B, and 77% of influenza A without any extraction performed on the clinical samples. The data also showed that extraction will be needed for parainfluenza virus, which was only identified correctly 24% of the time on un-extracted samples.

  17. Management of Respiratory Motion in Extracorporeal High-Intensity Focused Ultrasound Treatment in Upper Abdominal Organs: Current Status and Perspectives

    SciTech Connect (OSTI)

    Muller, A., E-mail: arnaud.muller@chu-lyon.fr [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France); Petrusca, L.; Auboiroux, V. [University of Geneva, Department of Radiology, Faculty of Medicine (Switzerland)] [University of Geneva, Department of Radiology, Faculty of Medicine (Switzerland); Valette, P. J. [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France)] [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France); Salomir, R. [University of Geneva, Department of Radiology, Faculty of Medicine (Switzerland)] [University of Geneva, Department of Radiology, Faculty of Medicine (Switzerland); Cotton, F. [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France)] [Centre Hospitalier Lyon Sud, Service de Radiologie, Hospices Civils de Lyon (France)

    2013-12-15T23:59:59.000Z

    Extracorporeal high-intensity focused ultrasound (HIFU) is a minimally invasive therapy considered with increased interest for the ablation of small tumors in deeply located organs while sparing surrounding critical tissues. A multitude of preclinical and clinical studies have showed the feasibility of the method; however, concurrently they showed several obstacles, among which the management of respiratory motion of abdominal organs is at the forefront. The aim of this review is to describe the different methods that have been proposed for managing respiratory motion and to identify their advantages and weaknesses. First, we specify the characteristics of respiratory motion for the liver, kidneys, and pancreas and the problems it causes during HIFU planning, treatment, and monitoring. Second, we make an inventory of the preclinical and clinical approaches used to overcome the problem of organ motion. Third, we analyze their respective benefits and drawbacks to identify the remaining physical, technological, and clinical challenges. We thereby consider the outlook of motion compensation techniques and those that would be the most suitable for clinical use, particularly under magnetic resonance thermometry monitoring.

  18. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01T23:59:59.000Z

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  19. Similarities of host defense mechanisms against pulmonary infectious disease in animals and man

    SciTech Connect (OSTI)

    Green, G.M.

    1984-01-01T23:59:59.000Z

    Evidence linking exposure to air pollutants with increased susceptibility to infectious diseases in humans comes from epidemiological, clinical, and experimental laboratory studies. The data suggest that the most common, and perhaps the most sensitive, index of the pulmonary effect of air pollutant exposure is on post upper respiratory infection, prolonged cough, phlegm, and purulent sputum. Experimental models of these relationships for extrapolation to humans should be able to measure such minor changes in symptomatology and physiology rather than require major lethal events. The bacterial aerosol model for quantifying nonspecific defense mechanisms of the bronchopulmonary tree utilizing nonpathogenic organisms fulfills this criterion. The function of the six major components of pulmonary antimicrobial defense mechanisms - including aerodynamic filtration, secretory respiratory tract fluid, fluid transport at the alveolar and bronchial levels, the phagocytic function of alveolar macrophages, the augmenting mechanisms of blood-derived inflammatory cells, and the secretory and cellular-specific immune mechanisms and their mediator products - can all be quantified by this experimental animal model system. The defensive functions are remarkably similar across animal species, and available human data suggest that findings obtained using the model may be extrapolatred to humans.

  20. A Manual of Poultry Diseases.

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01T23:59:59.000Z

    " of ocular leucosis is specific. Hatchery and Breeder Flock Health Management Sanitation is a much used, but poorly defined word. The usual implication is that sanitation is a universally understood practice that may be applied to prevent all diseases... must be based on the nature of specific diseases. The ;kmbiguity surrounding the term "sanitation" can be avoided by using a term "management and sanitation for disease prevention." This phrase then would be defined as all practices, specific...

  1. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    said. "In the same way we check the weather each morning, individuals and public health officials can monitor disease incidence and plan for the future based on today's...

  2. MFR PAPER 1300 Shellfish Diseases

    E-Print Network [OSTI]

    promise for the efficient recycling of organic waste materials, such as agricultural wastes, and metazoan parasitic and infectious agents. In addition, predators, toxic agents, and fouling organisms studied. DISEASES OF SHELLFISH A list of organisms that cause com- mon diseases in oysters is shown

  3. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09T23:59:59.000Z

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  4. Lessons from a rare disease

    E-Print Network [OSTI]

    Dutchen, Stephanie Lynn

    2009-01-01T23:59:59.000Z

    Progeria is a genetic aging disease of childhood affecting an estimated one in four to eight million births. Children with progeria experience a range of developmental disorders and aging-like symptoms, including wrinkled ...

  5. A Manual of Poultry Diseases.

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01T23:59:59.000Z

    surrounding the term "sanitation" can be avoided by using the expression "management and sanitation for disease preven- , tion." This phrase then would be defined as all practices, specific and nonspecific, that the poultry- man applies to ptevent.... Change litter and thoroughly clean and disinfect the house and equipment between each group of birds. While litter selection and management is a large subject, applying this recommendation as a general practice will prevent many disease and parasite...

  6. A Century of Progress: Milestones in Sickle Cell Disease

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Disease? Sickle cell disease, also known as sickle cell anemia, is inherited. People who have the disease

  7. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    W, et al. : Interstitial lung disease in progressiveGL, Myers JL: Diffuse lung disease: diagnostic accuracy ofsurgical biopsy of the lung. Radiology 1997, 205:229–234.

  8. Domestic smoke pollution and acute respiratory infections in a rural community of the hill region of Nepal

    SciTech Connect (OSTI)

    Pandey, M.R.; Neupane, R.P.; Gautam, A.; Shrestha, I.B. (Mrigendra Medical Trust, Kathmandu (Nepal))

    1989-01-01T23:59:59.000Z

    Acute respiratory infections (ARI) are the cause of death for at least five million children per year under five years of age. Most of these deaths occur in developing countries. Domestic smoke pollution is very common in many parts of the developing world, and appropriate technology, such as smokeless stoves, is available to reduce this type of pollution. The present study has been undertaken in a rural community of the hill region of Nepal to find out if there is any association between domestic smoke pollution and ARI in infants and children younger than two years of age. This preliminary study showed that episodes of moderate and severe ARI increased with increases in the level of exposure to domestic smoke pollution, thus suggesting domestic smoke pollution to be an important, preventable risk factor of ARI.

  9. Heart Disease and Early Heart Attack Care

    E-Print Network [OSTI]

    Ohta, Shigemi

    Heart Disease and Early Heart Attack Care Pamela Kostic, RN, CCCC, Chest Pain Coordinator, Stony Risk Factors · EHAC & Prevention #12;Heart disease includes a number of problems affecting the heart and the blood vessels in the heart. #12;Types of heart disease include: · Coronary artery disease (CAD) · Angina

  10. Radiologic atlas of rheumatic diseases

    SciTech Connect (OSTI)

    Dihlmann, W.

    1986-01-01T23:59:59.000Z

    This book is an ''atlas of rheumatic joint disease'' selected from 20 years of personal experience by the author. The author sets a goal of demonstrating the value of soft-tissue imaging in the diagnosis of early joint disease. This goal is achieved with high quality reproductions, many of which are presented in duplicate to illustrate bone and soft-tissue changes. The contents include an introductory overview of the ''Mosaic of Arthritis'' followed by sections on adult rheumatoid arthritis, seronegative spondyloarthropathies, classic collagen disease, enthesiopathies, and lastly a section on gout and psuedogout. The subject index is specific and indexes figures with boldface type. Each section is introduced by a brief outline or overview of the radiographic spectrum of the joint disorder to be illustrated.

  11. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29T23:59:59.000Z

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  12. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches linked to the severity of allergic disease. The contribution of house dust mites, cockroaches, animal some of the strongest evidence sug- gests a compelling link between exposure to passive smoking

  13. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02T23:59:59.000Z

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  14. Effects of Respiratory Motion on Passively Scattered Proton Therapy Versus Intensity Modulated Photon Therapy for Stage III Lung Cancer: Are Proton Plans More Sensitive to Breathing Motion?

    SciTech Connect (OSTI)

    Matney, Jason; Park, Peter C. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); The University of Texas Graduate School of Biomedical Sciences, Houston, Texas (United States); Bluett, Jaques [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chen, Yi Pei [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); The University of Texas Graduate School of Biomedical Sciences, Houston, Texas (United States); Liu, Wei; Court, Laurence E. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Li, Heng [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe, E-mail: rmohan@mdanderson.org [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-11-01T23:59:59.000Z

    Purpose: To quantify and compare the effects of respiratory motion on paired passively scattered proton therapy (PSPT) and intensity modulated photon therapy (IMRT) plans; and to establish the relationship between the magnitude of tumor motion and the respiratory-induced dose difference for both modalities. Methods and Materials: In a randomized clinical trial comparing PSPT and IMRT, radiation therapy plans have been designed according to common planning protocols. Four-dimensional (4D) dose was computed for PSPT and IMRT plans for a patient cohort with respiratory motion ranging from 3 to 17 mm. Image registration and dose accumulation were performed using grayscale-based deformable image registration algorithms. The dose–volume histogram (DVH) differences (4D-3D [3D = 3-dimensional]) were compared for PSPT and IMRT. Changes in 4D-3D dose were correlated to the magnitude of tumor respiratory motion. Results: The average 4D-3D dose to 95% of the internal target volume was close to zero, with 19 of 20 patients within 1% of prescribed dose for both modalities. The mean 4D-3D between the 2 modalities was not statistically significant (P<.05) for all dose–volume histogram indices (mean ± SD) except the lung V5 (PSPT: +1.1% ± 0.9%; IMRT: +0.4% ± 1.2%) and maximum cord dose (PSPT: +1.5 ± 2.9 Gy; IMRT: 0.0 ± 0.2 Gy). Changes in 4D-3D dose were correlated to tumor motion for only 2 indices: dose to 95% planning target volume, and heterogeneity index. Conclusions: With our current margin formalisms, target coverage was maintained in the presence of respiratory motion up to 17 mm for both PSPT and IMRT. Only 2 of 11 4D-3D indices (lung V5 and spinal cord maximum) were statistically distinguishable between PSPT and IMRT, contrary to the notion that proton therapy will be more susceptible to respiratory motion. Because of the lack of strong correlations with 4D-3D dose differences in PSPT and IMRT, the extent of tumor motion was not an adequate predictor of potential dosimetric error caused by breathing motion.

  15. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29T23:59:59.000Z

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  16. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  17. Polar lipid fatty acids, LPS-hydroxy fatty acids, and respiratory quinones of three Geobacter strains, and variation with electron acceptor

    SciTech Connect (OSTI)

    Hedrick, David B.; Peacock, Aaron; Lovley, Derek; Woodard, Trevor L.; Nevin, Kelly P.; Long, Philip E.; White, David C.

    2009-02-01T23:59:59.000Z

    The polar lipid fatty acids, lipopolysaccharide hydroxy-fatty acids, and respiratory quinones of Geobacter metallireducens str. GS-15, Geobacter sulfurreducens str. PCA, and Geobacter bemidjiensis str. Bem are reported. Also, the lipids of G. metallireducens were compared when grown with Fe3+ or nitrate as electron acceptors and G. sulfurreducens with Fe3+ or fumarate. In all experiments, the most abundant polar lipid fatty acids were 14:0, i15:0, 16:1*7c, 16:1*5c, and 16:0; lipopolysaccharide hydroxyfatty acids were dominated by 3oh16:0, 3oh14:0, 9oh16:0, and 10oh16:0; and menaquinone-8 was the most abundant respiratory quinone. Some variation in lipid proWles with strain were observed, but not with electron acceptor.

  18. Are You at Risk for Heart Disease?

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Sakit sa Puso? Malusog na Puso, Malusog na Pamilya #12;Did you know that heart disease is a serious problem

  19. Coronary Heart Disease, Hypertension, Stroke, and

    E-Print Network [OSTI]

    Meagher, Mary

    Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart · Disease process: coronary and arms Myocardial infarction - heart attack, ischemia - local blood supply decreased resulting in cell

  20. Crystallization of Mitochondrial Respiratory Complex II fromChicken Heart: A Membrane-Protein Complex Diffracting to 2.0Angstrom

    SciTech Connect (OSTI)

    Huang, Li-shar; Borders, Toni M.; Shen, John T.; Wang, Chung-Jen; Berry, Edward A.

    2004-12-17T23:59:59.000Z

    Procedure is presented for preparation of diffraction-quality crystals of a vertebrate mitochondrial respiratory Complex II. The crystals have the potential to diffract to at least 2.0 Angstrom with optimization of post-crystal-growth treatment and cryoprotection. This should allow determination of the structure of this important and medically relevant membrane protein complex at near-atomic resolution and provide great detail of the mode of binding of substrates and inhibitors at the two substrate-binding sites.

  1. Variation in rectal temperature, respiratory rate, and pulse rate of cattle as related to variations in solar radiation, air temperature, wind velocity, and vapor pressure

    E-Print Network [OSTI]

    Quazi, Mohammad Fazlur Rahim

    1955-01-01T23:59:59.000Z

    VARIATION IN RECTAL TEMPERATURE, RESPIRATORY RATE, AND PULSE RATE GF CATTLE AS RELATED TO VARIATIONS IN SOLAR RADIATION, AIR TEMPERATURE, WIND VELOCITY, AND VAPOR PRESSURE A Dissertation By Mohammad Fazlur Rahim Quazi Approved as to style... Dissertation By Mohammad Fazlur Rahim tyiazi Submitted to the Graduate School of the Agricultural and Mechanical College of Texas in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY May 1955 Major Subject: Genetics ? ?4...

  2. Daily targeting of liver tumors: Screening patients with a mock treatment and using a combination of internal and external fiducials for image-guided respiratory-gated radiotherapy

    SciTech Connect (OSTI)

    Krishnan, Sunil; Briere, Tina Marie; Dong Lei; Murthy, Ravi; Ng, Chaan; Balter, Peter; Mohan, Radhe; Gillin, Michael T.; Beddar, A. Sam [Department of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas 77030 (United States); Department of Radiation Physics, MD Anderson Cancer Center, Houston, Texas 77030 (United States); Department of Diagnostic Radiology, MD Anderson Cancer Center, Houston, Texas 77030 (United States); Department of Radiation Physics, MD Anderson Cancer Center, Houston, Texas 77030 (United States)

    2007-12-15T23:59:59.000Z

    The feasibility and accuracy of using a mock treatment to screen suitable patients for respiratory-gated image-guided radiotherapy was investigated. Radio-opaque fiducials implanted adjacent to the liver tumor were used for online positioning to minimize the systematic error in patient positioning. The consistency in the degree of correlation between the external and internal fiducials was analyzed during a mock treatment. This technique could screen patients for gated therapy, reduce setup inaccuracy, and possibly individualize treatment margins.

  3. Controlling Diseases on Ornamental Plants.

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01T23:59:59.000Z

    powder is used as a spray to control powdery mildew and foliage diseases. It is available as Daconil 2787?, Bravo? and Ferti-Iome Broad Spectrum Liquid Fungicide?. Formaldehyde: This is a 37 percent solution in water and methanol which is used... and move it over the loosened soil. Drain tile or iron pipe buried in the soil helps to distribute the ste~m. Heat the soil until a medium-sized potato buried several inches deep is cooked thoroughly. Use formaldehyde as manufacturer directs. Water...

  4. Diseases of Peaches and Plums.

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01T23:59:59.000Z

    Uetial ' . " ~. -~c _ '1-" ,," 'J .~. ," .. " Each year diseases destroy a large portion of the potential fruit crop in Texas. This loss begins in the orchard and continues until the fruit is con sumed. Complete lack of production on improperly sprayed trees... enough pressure to break through the bark and flow down the outside of a tree limb. Cankers will have a sour smell similar to that fol lowing a freeze. Although leaf spotting has been reported, it does not always occur. In Texas, leaf spotting has...

  5. Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development M, Egypt. Abstract--Chronic Obstructive Pulmonary Disease (COPD) refers to a group of lung diseases bronchitis. Pulmonary emphysema is defined as a lung disease characterized by "abnormal enlargement

  6. Induction of T helper 3 regulatory cells by dendritic cells infected with porcine reproductive and respiratory syndrome virus

    SciTech Connect (OSTI)

    Silva-Campa, Erika; Flores-Mendoza, Lilian; Resendiz, Monica; Pinelli-Saavedra, Araceli; Mata-Haro, Veronica [Centro de Investigacion en Alimentacion y Desarrollo, A.C. Hermosillo, Sonora (Mexico); Mwangi, Waithaka [Department of Veterinary Pathobiology, Texas A and M University, College Station, TX (United States); Hernandez, Jesus, E-mail: jhdez@ciad.m [Centro de Investigacion en Alimentacion y Desarrollo, A.C. Hermosillo, Sonora (Mexico)

    2009-05-10T23:59:59.000Z

    Delayed development of virus-specific immune response has been observed in pigs infected with the porcine reproductive and respiratory syndrome virus (PRRSV). Several studies support the hypothesis that the PRRSV is capable of modulating porcine immune system, but the mechanisms involved are yet to be defined. In this study, we evaluated the induction of T regulatory cells by PRRSV-infected dendritic cells (DCs). Our results showed that PRRSV-infected DCs significantly increased Foxp3{sup +}CD25{sup +} T cells, an effect that was reversible by IFN-alpha treatment, and this outcome was reproducible using two distinct PRRSV strains. Analysis of the expressed cytokines suggested that the induction of Foxp3{sup +}CD25{sup +} T cells is dependent on TGF-beta but not IL-10. In addition, a significant up-regulation of Foxp3 mRNA, but not TBX21 or GATA3, was detected. Importantly, our results showed that the induced Foxp3{sup +}CD25{sup +} T cells were able to suppress the proliferation of PHA-stimulated PBMCs. The T cells induced by the PRRSV-infected DCs fit the Foxp3{sup +}CD25{sup +} T helper 3 (Th3) regulatory cell phenotype described in the literature. The induction of this cell phenotype depended, at least in part, on PRRSV viability because IFN-alpha treatment or virus inactivation reversed these effects. In conclusion, this data supports the hypothesis that the PRRSV succeeds to establish and replicate in porcine cells early post-infection, in part, by inducing Th3 regulatory cells as a mechanism of modulating the porcine immune system.

  7. The South Karelia Air Pollution Study. The effects of malodorous sulfur compounds from pulp mills on respiratory and other symptoms

    SciTech Connect (OSTI)

    Jaakkola, J.J.; Vilkka, V.; Marttila, O.; Jaeppinen, P.H.; Haahtela, T. (South Karelia Allergy and Environment Institute, Espoo (Finland))

    1990-12-01T23:59:59.000Z

    The paper mills in South Karelia, the southeast part of Finland, are responsible for releasing a substantial amount of malodorous sulfur compounds such as hydrogen sulfide (H2S), methyl mercaptan (CH3SH), and methyl sulfides ((CH3)2S and (CH3)2S2), into ambient air. In the most polluted residential area the annual mean concentrations of hydrogen sulfide and methyl mercaptan are estimated to be 8 and 2 to 5 micrograms/m3 and the highest daily average concentration 100 and 50 micrograms/m3. The annual mean and highest daily concentrations of sulfur dioxide (SO2) are very low. We studied the effects of malodorous sulfur compounds on eye, nasal and respiratory symptoms, and headache in adults. A cross-sectional self-administered questionnaire was distributed in February 1987 and responded to by 488 adults living in a severely (n = 198), a moderately (n = 204), and a nonpolluted community (n = 86). This included questions about occurrence of the symptoms of interest during the previous 4 wk and 12 months and individual, behavioral, and other environmental determinants of the symptoms. The response rate was 83%. The odds ratios (OR) for symptoms experienced often or constantly in severely versus nonpolluted and moderately versus nonpolluted communities were estimated in logistic regression analysis controlling potential confounders. The odds ratios for eye (moderate exposure OR 11.70, Cl95% 2.33 to 58.65; severe exposure OR 11.78, Cl95% 2.35 to 59.09) and nasal symptoms (OR 2.01, Cl95% 0.97 to 4.15; OR 2.19, Cl95% 1.06 to 4.55) and cough (OR 1.89, Cl95% 0.61 to 5.86; OR 3.06, Cl95% 1.02 to 9.29) during the previous 12 months were increased, with a dose-response pattern.

  8. Distributions of respiratory contaminants from a patient with different postures and exhaling modes in a single-bed inpatient room

    E-Print Network [OSTI]

    Chen, Qingyan "Yan"

    and contaminant transport in inpatient rooms and to improve the ventilation system design for the rooms. Many studies have been conducted on airborne disease transmission and ventilation systems in hospitals. Li et that ventilation systems play a very important role in the contaminant distribution in an inpatient room. Qian et

  9. airway stenoses involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    equine respiratory diseases. RAO is an allergic asthma like disease of the middle-aged horses while the R. equi pneumonia affects only young foals. Respiratory... Kachroo,...

  10. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    undergoing surgical biopsy of the lung. Radiology 1997, 205:disease. In Pathology of the Lung. Edited by Thurlbeck WM,organs, most frequently the lungs and gastrointes- tinal

  11. Enzyme replacement therapy for Pompe disease

    E-Print Network [OSTI]

    Burris, Ryan Jonathan William

    2010-01-01T23:59:59.000Z

    CALIFORNIA, SAN DIEGO Enzyme Replacement Therapy for Pompe3 1.3 Enzyme Replacement Therapy for Pompe Disease…………………… 5Receptor ERT – Enzyme Replacement Therapy LSD – Lysosomal

  12. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  13. Fracture, aging and disease in bone

    E-Print Network [OSTI]

    Ager, J.W.; Balooch, G.; Ritchie, R.O.

    2006-01-01T23:59:59.000Z

    on glucocorticoid-induced osteoporosis. Rheumatic DiseaseGlucocorticoid-induced osteoporosis. Endocrinol Metab. Clin.of cortico-steroid osteoporosis. A meta-analysis. Osteoporos

  14. Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Disease: Changes in Lung Function

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Lung (2010) 188:143–149 DOI 10.1007/s00408-009-Tissue Disease-Associated Interstitial Lung Disease:Changes in Lung Function Brent W. Kinder • Cyrus Shariat •

  15. A "blind" study of the power spectra analysis of respiratory sounds at the trachea of a sample of pulmonary insufficiency patients and normal subjects

    E-Print Network [OSTI]

    Wolf, Brenda Ann

    1985-01-01T23:59:59.000Z

    the condition of the lungs. The slow progress is due to: (1) a variety of human factor problems, (2) the limitations of the instrumentation, (3) the lack of total understanding of the mechanism of production of respiratory sounds, and (4) the lack... was a "blind s'tudy The equipment used in the analysis of the magnetic tapes consisted of the following components: 1. Ampex 2200 PM analog tape recorder 2, Datum Time Code Generator/Reader Model 9300 3. 20 Hz, 1800 Hz low pass filters 4. 100 Hz...

  16. COMMON DISEASES OF FUR BEARING ANIMALS II. DISEASES OF CHINCHILLAS, NUTRIA, AND RABBITS*

    E-Print Network [OSTI]

    COMMON DISEASES OF FUR BEARING ANIMALS II. DISEASES OF CHINCHILLAS, NUTRIA, AND RABBITS* T. J. Pridhamt, Joan Buddt, and L. H. A. Karstadt DISEASES OF THE CHINCHILLA BACTERIAL INFECTIONS and errors in management are the most common causes of death in the chinchillas submitted to this laboratory. LISTERIOSIS

  17. Coronary Heart Disease, Hypertension, Stroke, and

    E-Print Network [OSTI]

    Meagher, Mary

    Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview to illnesses caused by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart that radiates across the chest and arms Ø Myocardial infarction - heart attack, ischemia - local blood supply

  18. X-ray atlas of rheumatic diseases

    SciTech Connect (OSTI)

    Dihlmann, W.

    1986-01-01T23:59:59.000Z

    This atlas comprises instructive X-rays of the various inflammatory rheumatic joint diseases in all stages at the extremities and the spinal column. In addition, the complex pattern of the wide range of arthroses, also known as degenerative rheumatic disease is included. Besides the instructive pointers to X-ray diagnosis, the book is also a guide to differential diagnosis. Hence, this book is actually an X-ray atlas of joint diseases in general. Selected Contents: Introduction: What Does ''Rheumatism'' Actually Mean./Radiographic Methodology in Rheumatic Diseases of the Locomotor System/The Mosaic of Arthritis/Adult Rheumatoid Arthritis/Seronegative Spondylarthritis/Classic Collagen Diseases/Enthesiopathies/Gout-Pseudogout

  19. Epidemiological-environmental study of diesel bus garage workers: acute effects of NO/sub 2/ and respirable particulate on the respiratory system

    SciTech Connect (OSTI)

    Gamble, J.; Jones, W.; Minshall, S.

    1987-02-01T23:59:59.000Z

    Personal samples of nitrogen dioxide (NO/sub 2/) and respirable particulate (RP) were collected over the shift on 232 workers in four diesel bus garages. Response was assessed by an acute respiratory questionnaire and before and after shift spirometry. Measures of exposure to NO/sub 2/ and RP were associated with work-related symptoms of cough; itching, burning, or watering eyes; difficult or labored breathing; chest tightness; and wheeze. The prevalence of burning eyes, headaches, difficult or labored breathing, nausea, and wheeze experienced at work were higher in the diesel bus garage workers than in a comparison population of battery workers, while the prevalence of headaches was reduced. Mean reductions in forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), peak flow, and flows at 50 and 75% of FVC were not obviously different from zero. There was no detectable association of exposure to NO/sub 2/ or respirable particulate and acute reductions in pulmonary function. Workers who often had respiratory work-related symptoms generally had a slightly greater mean acute reduction in FEV1 and FEF50 than did those who did not have these symptoms, but these differences were not statistically significant.

  20. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01T23:59:59.000Z

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  1. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01T23:59:59.000Z

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  2. Chemicals for Plant Disease Control at Home

    E-Print Network [OSTI]

    Ong, Kevin

    2007-10-30T23:59:59.000Z

    common chemical names and the corresponding chemical name for each active ingredient. Kevin Ong* ?Assistant Professor and Extension Plant Pathologist, The Texas A&M University System Table 1. Plant disease control chemicals. Common name Chemical name 1...

  3. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01T23:59:59.000Z

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  4. Restoration of Endangered White Abalone, Haliotis sorenseni: Resource Assessment, Genetics, Disease and Culture of Captive Abalone

    E-Print Network [OSTI]

    Burton, Ronald S.; McCormick, Thomas B.; Moore, James D.; Friedman, Carolyn S.

    2008-01-01T23:59:59.000Z

    Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,

  5. adult celiac disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: with a dietitian or physician who specializes in celiac disease. People with celiac disease should always read food for Celiac Awareness; Cynthia Kupper,...

  6. arthritis disease activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systemic, inflammatory disease causing disability. Identifying factors that influence the impact of the disease is important for planning adequate (more) Kuhlow, Heide 2007-01-01...

  7. ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease

    E-Print Network [OSTI]

    Cinabro, David

    ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease Department strengths in diabetes, obesity and metabolic disease. Outstanding candidates with expertise

  8. Integrated Molecular Signature of Disease: Analysis of Influenza...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected...

  9. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  10. The Seattle Structure Genomics Center for Infectious Disease...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Seattle Structure Genomics Center for Infectious Disease (SSGCID). The Seattle Structure Genomics Center for Infectious Disease (SSGCID). Abstract: The NIAID-funded Seattle...

  11. alzheimers disease amyloid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  12. alzheimer disease current: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diagnosis of Alzheimers disease: CiteSeer Summary: update on combining genetic and brain-imaging measures Gary W. Small, MD Diagnosis of Alzheimers disease is often missed...

  13. alzheimer disease amyloid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  14. anthracnose disease control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

  15. anthracnose disease caused: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

  16. A Systems Biology Approach to Infectious Disease Research: Innovating...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm. A Systems Biology Approach to Infectious Disease Research: Innovating the...

  17. Intracellular shunting of O{sub 2}{sup ?} contributes to charge compensation and preservation of neutrophil respiratory burst in the absence of voltage-gated proton channel activity

    SciTech Connect (OSTI)

    Decleva, Eva [Department of Life Sciences, University of Trieste, Trieste (Italy); Menegazzi, Renzo, E-mail: menegazz@units.it [Department of Life Sciences, University of Trieste, Trieste (Italy); Fasolo, Alba [Department of Life Sciences, University of Trieste, Trieste (Italy); Defendi, Federica [Université Joseph Fourier, GREPI/AGIM CNRS FRE 3405, Grenoble (France); Sebastianutto, Michele; Dri, Pietro [Department of Life Sciences, University of Trieste, Trieste (Italy)

    2013-07-15T23:59:59.000Z

    Proton efflux via voltage-gated proton channels (Hv1) is considered to mediate the charge compensation necessary to preserve NADPH oxidase activity during the respiratory burst. Using the Hv1 inhibitor Zn{sup 2+}, we found that the PMA-induced respiratory burst of human neutrophils is inhibited when assessed as extracellular production of O{sub 2}{sup ?} and H{sub 2}O{sub 2}, in accordance with literature studies, but, surprisingly, unaffected when measured as oxygen consumption or total (extracellular plus intracellular) H{sub 2}O{sub 2} production. Furthermore, we show that inhibiting Hv1 with Zn{sup 2+} results in an increased production of intracellular ROS. Similar results, i.e. decreased extracellular and increased intracellular ROS production, were obtained using a human granulocyte-like cell line with severely impaired Hv1 expression. Acidic extracellular pH, which dampens proton efflux, also augmented intracellular production of H{sub 2}O{sub 2}. Zinc caused an increase in the rate but not in the extent of depolarization and cytosolic acidification indicating that mechanisms other than proton efflux take part in charge compensation. Our results suggest a hitherto unpredicted mechanism of charge compensation whereby, in the absence of proton efflux, part of O{sub 2}{sup ?} generated within gp91{sup phox} in the plasma membrane is shunted intracellularly down electrochemical gradient to dampen excessive depolarization. This would preserve NADPH oxidase activity under conditions such as the inflammatory exudate in which the acidic pH hinders charge compensation by proton efflux. Highlights: • Neutrophils’ respiratory burst is not inhibited by the H{sup +} channel inhibitor Zn{sup 2+}. • Intracellular production of O{sub 2}{sup ?} and H{sub 2}O{sub 2} is increased in the presence of Zn{sup 2+}. • Intracellular H{sub 2}O{sub 2} production is increased in H{sup +} channels knock-down cells. • Zn{sup 2+} increases the rate but not the extent of depolarization and pH{sub i} decrease. • Intracellular shunting of O{sub 2}{sup ?} contributes to charge compensation in neutrophils.

  18. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D. [Hospital of the Univ. of Pennsylvania, Philadelphia, PA (United States)

    1996-10-01T23:59:59.000Z

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  19. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26T23:59:59.000Z

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  20. Thomas E. Hinds Although many diseases attack aspen, relatively few

    E-Print Network [OSTI]

    DISEASES Thomas E. Hinds Although many diseases attack aspen, relatively few kill or seriously of aspen, whereas there are subtle differ- ences in distribution between the important decay fungi. Foliage Diseases Fungus Diseases Many fungi are capable of attacking aspen leaves, from juvenile growth

  1. Questions and Answers What is meningococcal disease? How do you get it?

    E-Print Network [OSTI]

    Hickman, Mark

    through droplets of respiratory or throat secretions, by kissing, sneezing or coughing on someone. Basic steps like covering your nose or mouth when you sneeze or cough, washing and drying your hands can help

  2. Huntington's disease: underlying molecular mechanisms and emerging

    E-Print Network [OSTI]

    Morimoto, Richard

    transcriptional mechanism also dictates the expression of polygluta- mine proteins. Here, we summarize the key with no disease modifying treatments available [1]. At the molecular level, HD is caused by a CAG trinu- cleotide is composed of proteins involved in transcription, DNA maintenance, cell cycle regulation, cellular orga

  3. News you can use Disease management

    E-Print Network [OSTI]

    Isaacs, Rufus

    DISEASE MANAGEMENT PAGE 9 CALENDAR A u g u s t 2 5 , 2 0 1 0 V O L 1 , I S S U E 1 5 A Michigan State. Elm Valley Road in Suttons Bay. Speaker: Rufus Isaacs will discuss late-season insect management. More

  4. Major Oak Diseases and Their Control.

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01T23:59:59.000Z

    Station, Texas (Blaok Page bl-?OriglulBidletial? / . , ,;..,' ,- ; ~ ~ " trees of Texas and are also... important components of forests and rangelands. They are normally long-lived, possess the ability to withstand adverse weather and have been considered disease resistant. During the drought in the mid 1950s large expanses of oak trees began dying...

  5. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  6. Osteoporosis Osteoporosis is a disease character-

    E-Print Network [OSTI]

    SS-167-R05 Osteoporosis Osteoporosis is a disease character- ized by structural deterioration of bone tissue, leading to fragile bones and low bone mass. Osteoporosis can weaken bones and cause them" because bone loss occurs with- out symptoms. Many people may not know that they have osteoporosis until

  7. INFLAMMATORY BOWEL DISEASE: THE INSIDE DISH

    E-Print Network [OSTI]

    Stanford, Kyle

    to be aware of advances that can improve quality of life. UC Irvine Healthcare's H.H. Chao Comprehensive Center at UC Irvine Medical Center. Patients with Crohn's disease or ulcerative colitis benefit from 101 Jocelyne Miller, MD Medication Fix ­ Overview of Medical Treatments Nimisha K. Parekh, MD, MPH

  8. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Nizet, Victor

    ), and hybrid striped bass (Evans et al. 2000). Clinical symptoms of S. iniae infection in fish include loss from the freshwater dolphin Inia geoffrensis (Pier & Madin 1976), S. iniae infects a wide range of fish infection in humans who have handled diseased fish (Weinstein et al. 1997). Despite the need for novel

  9. Motor Control Abnormalities in Parkinson's Disease

    E-Print Network [OSTI]

    Motor Control Abnormalities in Parkinson's Disease Pietro Mazzoni, Britne Shabbott, and Juan Camilo Corte´s Motor Performance Laboratory, The Neurological Institute, Columbia University, New York, New. Motor symptoms can also be described in terms of motor control, a level of description that explains how

  10. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19T23:59:59.000Z

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  11. A Comparison of Amplitude-Based and Phase-Based Positron Emission Tomography Gating Algorithms for Segmentation of Internal Target Volumes of Tumors Subject to Respiratory Motion

    SciTech Connect (OSTI)

    Jani, Shyam S., E-mail: sjani@mednet.ucla.edu [Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, California (United States); Robinson, Clifford G. [Department of Radiation Oncology, Siteman Cancer Center, Washington University in St Louis, St Louis, Missouri (United States); Dahlbom, Magnus [Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California (United States); White, Benjamin M.; Thomas, David H.; Gaudio, Sergio; Low, Daniel A.; Lamb, James M. [Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, California (United States)

    2013-11-01T23:59:59.000Z

    Purpose: To quantitatively compare the accuracy of tumor volume segmentation in amplitude-based and phase-based respiratory gating algorithms in respiratory-correlated positron emission tomography (PET). Methods and Materials: List-mode fluorodeoxyglucose-PET data was acquired for 10 patients with a total of 12 fluorodeoxyglucose-avid tumors and 9 lymph nodes. Additionally, a phantom experiment was performed in which 4 plastic butyrate spheres with inner diameters ranging from 1 to 4 cm were imaged as they underwent 1-dimensional motion based on 2 measured patient breathing trajectories. PET list-mode data were gated into 8 bins using 2 amplitude-based (equal amplitude bins [A1] and equal counts per bin [A2]) and 2 temporal phase-based gating algorithms. Gated images were segmented using a commercially available gradient-based technique and a fixed 40% threshold of maximum uptake. Internal target volumes (ITVs) were generated by taking the union of all 8 contours per gated image. Segmented phantom ITVs were compared with their respective ground-truth ITVs, defined as the volume subtended by the tumor model positions covering 99% of breathing amplitude. Superior-inferior distances between sphere centroids in the end-inhale and end-exhale phases were also calculated. Results: Tumor ITVs from amplitude-based methods were significantly larger than those from temporal-based techniques (P=.002). For lymph nodes, A2 resulted in ITVs that were significantly larger than either of the temporal-based techniques (P<.0323). A1 produced the largest and most accurate ITVs for spheres with diameters of ?2 cm (P=.002). No significant difference was shown between algorithms in the 1-cm sphere data set. For phantom spheres, amplitude-based methods recovered an average of 9.5% more motion displacement than temporal-based methods under regular breathing conditions and an average of 45.7% more in the presence of baseline drift (P<.001). Conclusions: Target volumes in images generated from amplitude-based gating are larger and more accurate, at levels that are potentially clinically significant, compared with those from temporal phase-based gating.

  12. What You Should Know About Plant Diseases.

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01T23:59:59.000Z

    . From 1845 to 1860, plant disease caused a disaster in Irelantl. Late blight struck the potato- yrowing region and turned the fields into a black- ened, rotting mass. A million people diet1 because I the potato crop failed; numerous families.... OTHER CONDITIONS WHICH MAY CAUSE PLANT IN JURY 1. Drying winds 2. Excessive light 3. Excessive lime in the soil 4. Over-use of commercial fertilizer 5. Gas injury PARASITIC OR SAPROPHYTIC PLANTS MISTLETOE-Mistletoe is a parasitic flowering plant...

  13. Soil Fumigation for Plant Disease Control.

    E-Print Network [OSTI]

    Young, P. A. (Paul Allen); Godfrey, G. H. (George Harold)

    1943-01-01T23:59:59.000Z

    satisfactory results were secured wikh xylene, ethylene dichloride, sodium cyanide and formaldehyde. Paper impregnated wit11 hoof-and-horn glue, casein glue, or vegetttble paste, and adequately sealed at the edges, was most satisfactory for con- fining... of the fumigants were effec- tive when the funligants were tightly confined in the soil. Soil fumigation boxes, made gas-tight by glueing the boards together and sealing the cover, were very effective for confining fumeants to kill plant-disease fungi and other...

  14. Binding of the Respiratory Chain Inhibitor Antimycin to theMitochondrial bc1 Complex: A New Crystal Structure Reveals an AlteredIntramolecular Hydrogen-Bonding Pattern

    SciTech Connect (OSTI)

    Huang, Li-shar; Cobessi, David; Tung, Eric Y.; Berry, Edward A.

    2005-05-10T23:59:59.000Z

    Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial respiratory chain, binds to the quinone reduction site of the cytochrome bc1 complex.Structure-activity-relationship studies have shown that the N-formylamino-salicyl-amide group is responsible for most of the binding specificity, and suggested that a low pKa for the phenolic OH group and an intramolecular H-bond between that OH and the carbonyl O of the salicylamide linkage are important. Two previous X-ray structures of antimycin bound to vertebrate bc1 complex gave conflicting results. A new structure reported here of the bovine mitochondrial bc1 complex at 2.28Angstrom resolution with antimycin bound, allows us for the first time to reliably describe the binding of antimycin and shows that the intramolecular hydrogen bond described in solution and in the small-molecule structure is replaced by one involving the NH rather than carbonyl O of the amide linkage, with rotation of the amide group relative to the aromatic ring. The phenolic OH and formylamino N form H-bonds with conserved Asp228 of cyt b, and the formylamino O H-bonds via a water molecule to Lys227. A strong density the right size and shape for a diatomic molecule is found between the other side of the dilactone ring and the alpha-A helix.

  15. Associations of indoor carbon dioxide concentrations and environmental susceptibilities with mucous membrane and lower respiratory building related symptoms in the BASE study: Analyses of the 100 building dataset

    SciTech Connect (OSTI)

    Erdmann, Christine A.; Apte, Michael G.

    2003-09-01T23:59:59.000Z

    Using the US EPA 100 office-building BASE Study dataset, they conducted multivariate logistic regression analyses to quantify the relationship between indoor CO{sub 2} concentrations (dCO{sub 2}) and mucous membrane (MM) and lower respiratory system (LResp) building related symptoms, adjusting for age, sex, smoking status, presence of carpet in workspace, thermal exposure, relative humidity, and a marker for entrained automobile exhaust. In addition, they tested the hypothesis that certain environmentally-mediated health conditions (e.g., allergies and asthma) confer increased susceptibility to building related symptoms within office buildings. Adjusted odds ratios (ORs) for statistically significant, dose-dependent associations (p < 0.05) for dry eyes, sore throat, nose/sinus congestion, and wheeze symptoms with 100 ppm increases in dCO{sub 2} ranged from 1.1 to 1.2. These results suggest that increases in the ventilation rates per person among typical office buildings will, on average, reduce the prevalence of several building related symptoms by up to 70%, even when these buildings meet the existing ASHRAE ventilation standards for office buildings. Building occupants with certain environmentally-mediated health conditions are more likely to experience building related symptoms than those without these conditions (statistically significant ORs ranged from 2 to 11).

  16. Epidemiological-environemental study of lead acid battery workers. III. Chronic effects of sulfuric acid on the respiratory system and teeth

    SciTech Connect (OSTI)

    Gamble, J.; Jones, W.; Hancock, J.; Meckstroth, R.L.

    1984-10-01T23:59:59.000Z

    The effects of long-term exposure to sulfuric acid mist on the teeth and respiratory system were studied in 248 workers in five plants manufacturing lead acid batteries. The prevalence of cough, phlegm, dyspnea, and wheezing as determined by questionnaire were not associated with estimates of cumulative acid exposure. There was only one case of irregular opacities seen on the chest radiographs. There was no statistically significant association of reduced FEV/sub 1/ peak flow, FEF/sub 50/, and FEF/sub 75/ with acid exposure although the higher exposed group had lower mean values. FVC in the high exposure group showed a statistically significant reductioon compared to the low exposure group but there was no significant association when exposure was analyzed as a continuous variable. The ratio of observed to expected prevalence of teeth etching and erosion was about four times greater in the high acid-exposure group. The earliest case of etching occured after 4 months exposure to an estimated average exposure of 0.23 mg/m/sup 3/ sulfuric acid.

  17. Microdistribution and Long-Term Retention of 239Pu (NO3)4 in the Respiratory Tracts of an Acutely Exposed Plutonium Worker and Experimental Beagle Dogs

    SciTech Connect (OSTI)

    Nielsen, Christopher E.; Wilson, Dulaney A.; Brooks, Antone L.; McCord, Stacey; Dagle, Gerald E.; James, Anthony C.; Tolmachev, Sergei Y.; Thrall, Brian D.; Morgan, William F.

    2012-11-01T23:59:59.000Z

    The long-term retention of inhaled soluble forms of plutonium raises concerns as to the potential health effects in persons working in nuclear energy or the nuclear weapons program. The distributions of long-term retained inhaled plutonium-nitrate [239Pu (NO3)4] deposited in the lungs of an accidentally exposed nuclear worker (Human Case 0269) and in the lungs of experimentally exposed beagle dogs with varying initial lung depositions were determined via autoradiographs of selected histological lung, lymph node, trachea, and nasal turbinate tissue sections. These studies showed that both the human and dogs had a non-uniform distribution of plutonium throughout the lung tissue. Fibrotic scar tissue effectively encapsulated a portion of the plutonium and prevented its clearance from the body or translocation to other tissues and diminished dose to organ parenchyma. Alpha radiation activity from deposited plutonium in Human Case 0269 was observed primarily along the sub-pleural regions while no alpha activity was seen in the tracheobronchial lymph nodes of this individual. However, relatively high activity levels in the tracheobronchial lymph nodes of the beagles indicated the lymphatic system was effective in clearing deposited plutonium from the lung tissues. In both the human case and beagle dogs, the appearance of retained plutonium within the respiratory tract was inconsistent with current biokinetic models of clearance for soluble forms of plutonium. Bound plutonium can have a marked effect on the dose to the lungs and subsequent radiation exposure has the potential increase in cancer risk.

  18. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01T23:59:59.000Z

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  19. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01T23:59:59.000Z

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  20. Bleb Point: Mimicker of Pneumothorax in Bullous Lung Disease

    E-Print Network [OSTI]

    Gelabert, Christopher; Nelson, Mathew

    2015-01-01T23:59:59.000Z

    G, Biderman P, et al. “The lung point”: an REFERENCESof cystic and bullous lung disease. Chest Surg Clin N Am.S, Kaiser LR. Giant bullous lung disease: chest radiography

  1. alberta kidney disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD Baker, Chris I. 2 Kidney Dysplasia National Kidney and Urologic Diseases...

  2. asbestos induced diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease in a patient may be a marker for disease in household contacts. Patients with family members heavily exposed to asbestos should be strongly encouraged to quit smoking in...

  3. animal virus diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  4. animal disease models: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  5. Should we expect population thresholds for wildlife disease?

    E-Print Network [OSTI]

    Getz, Wayne M.

    of Zoology and Entomology, University of Pretoria, 0002 South Africa 6 Energy and Resources Group, University , Adam B. Smith6 and Andrea Swei4 1 Department of Environmental Science, Policy and Management of infectious disease are core concepts of disease ecology and underlie disease control policies based

  6. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  7. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  8. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  9. New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc

    E-Print Network [OSTI]

    Corona, C; Pensalfini, A; Frazzini, V; Sensi, S L

    2011-01-01T23:59:59.000Z

    39;s disease: brain deregulation of calcium and zinc [39;s disease: brain deregulation of calcium and zinc39;s disease: brain deregulation of calcium and zinc Gotz

  10. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01T23:59:59.000Z

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  11. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01T23:59:59.000Z

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  12. Visualizing Brain Metals in Health and Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrincetonUsing Maps1 -Visualizing Brain Metals in Health and Disease

  13. Genetic Contributions to Infectious Disease Risk Infectious disease in cattle production

    E-Print Network [OSTI]

    Life Research, Texas A&M University, West· Texas A&M University, Texas Tech University, and USDA associated with disease resistance. Researchers at Texas AgriLife Research are well positioned to address collaborations including scientists in the College of Veterinary Medicine and Bio- medical Sciences at Texas A

  14. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11T23:59:59.000Z

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  15. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01T23:59:59.000Z

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  16. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29T23:59:59.000Z

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  17. Does aluminum smelting cause lung disease

    SciTech Connect (OSTI)

    Abramson, M.J.; Wlodarczyk, J.H.; Saunders, N.A.; Hensley, M.J.

    1989-04-01T23:59:59.000Z

    The evidence concerning a relationship between work in the aluminum industry and lung disease has been reviewed using epidemiologic criteria. Adequate data on environmental exposure are rarely presented. Case series on aluminum potroom workers over the past 50 years have identified an asthmalike syndrome that appears to be due to an irritant rather than an allergic mechanism. These studies have been supported by evidence of within shift variability of measures of lung function. However, to date, there is inadequate evidence to resolve the question of whether potroom exposure initiates asthma or merely precipitates asthmalike symptoms in a predisposed individual. Cross-sectional studies have demonstrated evidence of reduced lung function, consistent with chronic airflow limitation. In exposed aluminum smelter workers compared to unexposed control subjects. Cigarette smoking, the major potential confounding variable, has been measured and accounted for in multivariate analyses. To date, evidence is lacking from longitudinal studies about the development of disabling chronic obstructive lung disease. Exposure to coal tar pitch volatiles in the production and consumption of anodes has biologic plausibility for an association of lung cancer with work in an aluminum smelter. Although retrospective mortality studies have failed to account for the probable high prevalence of smoking in blue collar workers, the relative risk of lung cancer is very low if present at all. Pulmonary fibrosis has not been shown to be a significant problem in aluminum smelter workers. Future research in the aluminum industry needs to concentrate on longitudinal studies, preferably with an inception cohort for the investigation of potroom asthma. 92 references.

  18. Thiacetarsamide therapy of heartworm disease in cats: a pharmacokinetic study

    E-Print Network [OSTI]

    Turner, Janet Lynn

    1988-01-01T23:59:59.000Z

    . Coughing and exerci se intolerance are common clinical signs. Coughing may be related to the severe pulmonary arterial disease or may be due to pneumonitis induced by the heartworm ~nfection. Severe cases of dirofilariasis may have hemoptysis... intermittent coughing and dyspnea, as well as anorexia and vomiting. Necropsies of cats with heartworm disease usually demonstrate a low worm burden. ' Cardiomegaly is less common in cats than in 23, 30-34 dogs with heartworm disease. Pulmonary arterial...

  19. avium complex disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Characterizing SNP-Disease Associations Using Bayesian Networks University of Kansas - KU ScholarWorks Summary: of computational methods in epistatic interaction...

  20. aleutian mink disease virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  1. aleutian disease virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  2. asbestos-related pleuropulmonary diseases: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  3. adnexal diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  4. anus diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  5. assessing disease activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    marked geographic clustering, and lack of reliable data on incidence, duration, and impact of the various disease syndromes. Non-health effects such as impoverishment,...

  6. adult kawasakis disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    association. Renee D. Goodwin; Daniel S. Pine 24 MRI-based Three dimensional shape analysis of thigh muscles: people with Chronic Obstructive Pulmonary Disease versus healthy...

  7. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01T23:59:59.000Z

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  8. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29T23:59:59.000Z

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  9. Toolbox Safety Talk Respiratory Protection

    E-Print Network [OSTI]

    Pawlowski, Wojtek

    Respirators (SAR) and Self Contained Breathing Apparatus (SCBA) are examples of atmosphere supplying

  10. Cardiovascular & Respiratory Modeling, Analysis & Control

    E-Print Network [OSTI]

    Batzel, Jerry

    of Grodins' system . . . . . 21 1.4 The Linear-quadratic Regulator Problem . . . . . . . . . . . . . 23 1-least-squares formulation of the param- eter identification problem . . . . . . . . . . . . . . 30 1.7 Numerical Results . . . . . . . . . . . . 47 2.1.2 The chemical control system for ventilation . . . . . 48 2.1.3 Structural features

  11. Cardiovascular & Respiratory Modeling, Analysis & Control

    E-Print Network [OSTI]

    Batzel, Jerry

    Problem . . . . . . . . . . . . . 23 1.5 The Bicycle Ergometer Test­ eter identification problem . . . . . . . . . . . . . . 30 1.7 Numerical Results . . . . . . . . . . . . 47 2.1.2 The chemical control system for ventilation . . . . . 48 2.1.3 Structural features

  12. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01T23:59:59.000Z

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  13. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01T23:59:59.000Z

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  14. Diseases of plantation forestry trees in eastern and southern Africa

    E-Print Network [OSTI]

    Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B are being allocated to the training of forestry staff andtreeimprovement.Theseefforts,aimedatstrengtheningthe forestry business, also embrace research on pests and diseases that might significantly reduce the value

  15. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  16. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  17. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  18. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  19. Development and Characterization of A Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out

    SciTech Connect (OSTI)

    Smith, S M; Danganan, L; Tammero, L; Vitalis, B; Lenhoff, R; Naraghi-arani, P; Hindson, B

    2007-08-06T23:59:59.000Z

    Lawrence Livermore National Laboratory (LLNL), in collaboration with the Department of Homeland Security (DHS) and the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Services (APHIS) has developed candidate multiplexed assays that may potentially be used within the National Animal Health Laboratory Network (NAHLN), the National Veterinary Services Laboratory (Ames, Iowa) and the Plum Island Animal Disease Center (PIADC). This effort has the ability to improve our nation's capability to discriminate between foreign animal diseases and those that are endemic using a single assay, thereby increasing our ability to protect food and agricultural resources with a diagnostic test which could enhance the nation's capabilities for early detection of a foreign animal disease. In FY2005 with funding from the DHS, LLNL developed the first version (Version 1.0) of a multiplexed (MUX) nucleic-acid-based RT-PCR assay that included signatures for foot-and-mouth disease virus (FMDV) detection with rule-out tests for two other foreign animal diseases (FADs) of swine, Vesicular Exanthema of Swine (VESV) and Swine Vesicular Disease Virus (SVDV), and four other domestic viral diseases Bovine Viral Diarrhea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1), Bluetongue virus (BTV) and Parapox virus complex (which includes Bovine Papular Stomatitis Virus [BPSV], Orf of sheep, and Pseudocowpox). In FY06, LLNL has developed Bovine and Porcine species-specific panel which included existing signatures from Version 1.0 panel as well as new signatures. The MUX RT-PCR porcine assay for detection of FMDV includes the FADs, VESV and SVD in addition to vesicular stomatitis virus (VSV) and porcine reproductive and respiratory syndrome (PRRS). LLNL has also developed a MUX RT-PCR bovine assay for detection of FMDV with rule out tests for the two bovine FADs malignant catarrhal fever (MCF), rinderpest virus (RPV) and the domestic diseases vesicular stomatitis virus (VSV), bovine viral diarrhea virus (BVDV), infectious bovine rhinotracheitus virus (BHV-1), bluetongue virus (BTV), and the Parapox viruses (which are of two bovine types) bovine papular stomatitis virus (BPSV) and psuedocowpox (PCP). A timeline for this development is presented in Table 1. The development of the Version 1.0 panel for FMDV rule-out and the most current efforts aimed to designed species specific panels has spanned over 2 1/2 years with multiple collaborative partnerships. This document provides a summary of the development, testing and performance data at OIE Stage 1 Feasibility into Stage 2 Assay Development and Standardization1 (see Table 2), gathered as of June 30th, 2007 for the porcine and bovine MUX assay panels. We present an overview of the identification and selection of candidate genetic signatures, the assay development process, and preliminary performance data for each of the individual signatures as characterized in the multiplexed format for the porcine and bovine panels. The Stage 1 Feasibility data of the multiplexed panels is presented in this report also includes relevant data acquired from the Version 1.0 panel as supporting information where appropriate. In contrast to last years effort, the development of the bovine and porcine panels is pending additional work to complete analytical characterization of FMDV, VESV, SVD, RPV and MCF. The signature screening process and final panel composition impacts this effort. The unique challenge presented this year was having strict predecessor limitations in completing characterization, where efforts at LLNL must precede efforts at PIADC, such challenges were alleviated in the 2006 reporting by having characterization data from the interlaboratory comparison and at Plum Island under AgDDAP project. We will present an addendum at a later date with additional data on the characterization of the porcine and bovine multiplex assays when that data is available. As a summary report, this document does not provide the details of signature generation, evaluation, and testing, nor does it provide spec

  20. Genetic Studies of Complex Human Diseases: Characterizing SNP-Disease Associations Using Bayesian Networks

    E-Print Network [OSTI]

    Han, Bing; Chen, Xue-wen; Talebizadeh, Zohreh; Xu, Hua

    2012-12-17T23:59:59.000Z

    (Suppl 3):S14 http://www.biomedcentral.com/1752-0509/6/S3/S14 © 2012 Han et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2...) heuristic search method can solve the classical XOR (Exclusive or) pro- blem [14]. We apply the EpiBN method to simulated datasets based on four disease models and three real datasets: Age-related Macular Degeneration (AMD) dataset, late-onset Alzheimer...

  1. Development and Characterization of a Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out Supplemental Materials

    SciTech Connect (OSTI)

    Smith, S; Danganan, L; Tammero, L; Lenhoff, R; Naraghi-arani, P; Hindson, B

    2007-08-06T23:59:59.000Z

    Lawrence Livermore National Laboratory (LLNL), in collaboration with the Department of Homeland Security (DHS) and the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Services (APHIS) has developed advanced rapid diagnostics that may be used within the National Animal Health Laboratory Network (NAHLN), the National Veterinary Services Laboratory (Ames, Iowa) and the Plum Island Animal Disease Center (PIADC). This effort has the potential to improve our nation's ability to discriminate between foreign animal diseases and those that are endemic using a single assay, thereby increasing our ability to protect animal populations of high economic importance in the United States. Under 2005 DHS funding we have developed multiplexed (MUX) nucleic-acid-based PCR assays that combine foot-and-mouth disease virus (FMDV) detection with rule-out tests for two other foreign animal diseases Vesicular Exanthema of Swine (VESV) and Swine Vesicular Disease (SVD) and four other domestic viral diseases Bovine Viral Diarrhea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1 or Infectious Bovine Rhinotracheitus IBR), Bluetongue virus (BTV) and Parapox virus complex (which includes Bovine Papular Stomatitis Virus BPSV, Orf of sheep, and Pseudocowpox). Under 2006 funding we have developed a Multiplexed PCR [MUX] porcine assay for detection of FMDV with rule out tests for VESV and SVD foreign animal diseases in addition to one other domestic vesicular animal disease vesicular stomatitis virus (VSV) and one domestic animal disease of swine porcine reproductive and respiratory syndrome (PRRS). We have also developed a MUX bovine assay for detection of FMDV with rule out tests for the two bovine foreign animal diseases malignant catarrhal fever (MCF), rinderpest virus (RPV) and the domestic diseases vesicular stomatitis virus (VSV), bovine viral diarrhea virus (BVDV), infectious bovine rhinotracheitus virus (BHV-1), bluetongue virus (BTV), and the Parapox viruses which are of two bovine types bovine papular stomatitis virus (BPSV) and psuedocowpox (PCP). This document provides details of signature generation, evaluation, and testing, as well as the specific methods and materials used. A condensed summary of the development, testing and performance of the multiplexed assay panel was presented in a 126 page separate document, entitled 'Development and Characterization of A Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out'. This supplemental document provides additional details of large amount of data collected for signature generation, evaluation, and testing, as well as the specific methods and materials used for all steps in the assay development and utilization processes. In contrast to last years effort, the development of the bovine and porcine panels is pending additional work to complete analytical characterization of FMDV, VESV, VSV, SVD, RPV and MCF. The signature screening process and final panel composition impacts this effort. The unique challenge presented this year was having strict predecessor limitations in completing characterization, where efforts at LLNL must preceed efforts at PIADC, such challenges were alleviated in the 2006 reporting by having characterization data from the interlaboratory comparison and at Plum Island under AgDDAP project. We will present an addendum at a later date with additional data on the characterization of the porcine and bovine multiplex assays when that data is available.

  2. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01T23:59:59.000Z

    nanotube arrays in dye-sensitized solar cells. Nano Letters,for improved dye-sensitized solar cells. ” Journal ofJin. “Enhancement of dye sensitized solar cell efficiency by

  3. Evaluation of Biomimetic and Alloy-based Materials for Orthopedic Applications 

    E-Print Network [OSTI]

    Guiza-Arguello, Viviana R.

    2013-07-17T23:59:59.000Z

    ICP-MS measures. ............................................................... 17 3. Cytotoxicity of uncoated NiMnSn alloys relative to NiMnSn alloys with uncrosslinked and crosslinked PAH/PAA coatings alloys as evaluated by DNA assessments... similarly harvested at day 14 for cell viability assessments. 2.3.3.3. Ion release Levels of Ni, Sn, and Mn ions released from the cultured alloy samples were monitored using Inductively Coupled Plasma Emission-Mass Spectroscopy (ICP-MS). At the time...

  4. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01T23:59:59.000Z

    Effects of titanium surface topography on bone integration:influence of surface chemistry and topography on the contactstiffness). Biomaterial surface topographies that have been

  5. SmartCast - Novel Textile Sensors for Embedded Pressure Sensing of Orthopedic Casts

    E-Print Network [OSTI]

    Danilovic, Andrew

    2013-01-01T23:59:59.000Z

    set_sleep_mode(SLEEP_MODE_PWR_DOWN); //enter Power-down Mode4 #define SEL2_PB0 8 #define SEL1_PD7 7 #define PWR_CTRL_PINPD5 #define PWR_CTRL_SD_CARD 6 //SmartCast bitFields for

  6. Textile-Based Sensor Development for the Continuous Monitoring of Proper Orthopedic Cast Fit

    E-Print Network [OSTI]

    Umsted, Carson Andrew

    2013-01-01T23:59:59.000Z

    Evaluation .. 13 Chapter 3: Sensorforce sensor worked very well in the evaluation phase andthe sensor performance was good in initial evaluation, to be

  7. An extensive analysis of modified nanotube surfaces for next-generation orthopedic implants

    E-Print Network [OSTI]

    Frandsen, Christine Jeanette

    2012-01-01T23:59:59.000Z

    of cemented versus cementless press-fit condylar total kneecemented implants or press-fit implants. For cemented boneThe second approach is to use press-fit implants, which are

  8. SmartCast - Novel Textile Sensors for Embedded Pressure Sensing of Orthopedic Casts

    E-Print Network [OSTI]

    Danilovic, Andrew

    2013-01-01T23:59:59.000Z

    interface GROUND //pinMode(SPI_MISO_PIN, OUTPUT); //DO NOTTO //digitalWrite(SPI_MISO_PIN, LOW); pinMode(hardwareSS,

  9. ArthroNav:Computer Assisted Navigation System for Orthopedic Surgery using Endoscopic Images

    E-Print Network [OSTI]

    Barreto, Joao

    Faculty of Science and Technology, University of Coimbra Coimbra, Portugal jpbar@{deec.uc.pt, isr of the endoscopic lens. We intend to adapt/design new computer vision techniques invariant to the numerous the procedure, the injured ligament is removed, and drill holes are open on the tibia Jo~ao. P. Barreto

  10. Quantum Leaps in Disease Detection Luis Garcia-Rubio, Ph.D.

    E-Print Network [OSTI]

    Meyers, Steven D.

    Quantum Leaps in Disease Detection Luis Garcia-Rubio, Ph.D. USF researchers are making quantum leaps in disease detection with the develop- ment of portable biosensors that can detect deadly diseases

  11. Adaptation of the modified Bouc–Wen model to compensate for hysteresis in respiratory motion for the list-mode binning of cardiac SPECT and PET acquisitions: Testing using MRI

    SciTech Connect (OSTI)

    Dasari, Paul K. R.; Shazeeb, Mohammed Salman [Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655 and Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609 (United States); Könik, Arda; Lindsay, Clifford; Mukherjee, Joyeeta M.; Johnson, Karen L.; King, Michael A., E-mail: Michael.King@umassmed.edu [Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655 (United States)

    2014-11-01T23:59:59.000Z

    Purpose: Binning list-mode acquisitions as a function of a surrogate signal related to respiration has been employed to reduce the impact of respiratory motion on image quality in cardiac emission tomography (SPECT and PET). Inherent in amplitude binning is the assumption that there is a monotonic relationship between the amplitude of the surrogate signal and respiratory motion of the heart. This assumption is not valid in the presence of hysteresis when heart motion exhibits a different relationship with the surrogate during inspiration and expiration. The purpose of this study was to investigate the novel approach of using the Bouc–Wen (BW) model to provide a signal accounting for hysteresis when binning list-mode data with the goal of thereby improving motion correction. The study is based on the authors’ previous observations that hysteresis between chest and abdomen markers was indicative of hysteresis between abdomen markers and the internal motion of the heart. Methods: In 19 healthy volunteers, they determined the internal motion of the heart and diaphragm in the superior–inferior direction during free breathing using MRI navigators. A visual tracking system (VTS) synchronized with MRI acquisition tracked the anterior–posterior motions of external markers placed on the chest and abdomen. These data were employed to develop and test the Bouc–Wen model by inputting the VTS derived chest and abdomen motions into it and using the resulting output signals as surrogates for cardiac motion. The data of the volunteers were divided into training and testing sets. The training set was used to obtain initial values for the model parameters for all of the volunteers in the set, and for set members based on whether they were or were not classified as exhibiting hysteresis using a metric derived from the markers. These initial parameters were then employed with the testing set to estimate output signals. Pearson’s linear correlation coefficient between the abdomen, chest, average of chest and abdomen markers, and Bouc–Wen derived signals versus the true internal motion of the heart from MRI was used to judge the signals match to the heart motion. Results: The results show that the Bouc–Wen model generated signals demonstrated strong correlation with the heart motion. This correlation was slightly larger on average than that of the external surrogate signals derived from the abdomen marker, and average of the abdomen and chest markers, but was not statistically significantly different from them. Conclusions: The results suggest that the proposed model has the potential to be a unified framework for modeling hysteresis in respiratory motion in cardiac perfusion studies and beyond.

  12. autoimmune disease triggered: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease (PD), to date there is still no definite cause or accepted treatment Hlava, Debbie Joy 2012-01-01 44 One (1) Postdoctoral position available at IMBB-FORTH, Heraklion,...

  13. artery disease results: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  14. artery disease evaluation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GIUSEPPE, RACHELE 2012-01-01 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  15. artery disease share: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    David Andrew 2007-01-01 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  16. artery disease combined: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  17. artery disease focus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  18. artery disease metabolismo: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 40 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  19. artery disease quantification: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  20. artery disease studied: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pressure Hielscher, Andreas 8 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  1. artery disease selection: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Andrew J. Lees 1991-01-01 56 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  2. artery disease trial: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 50 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  3. arterial occlusive disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  4. artery disease potential: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    fo... Yi, Li Ting 2013-01-01 56 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  5. artery disease involving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    E. Lundquist; James P. Ward 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  6. artery disease comparison: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 45 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  7. artery disease left: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Du Toit, Henning 2007-01-01 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  8. artery disease assessed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  9. artery disease longitudinal: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 51 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  10. artery disease cad: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hanson, Stephen Jos 18 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  11. arterial occlusive diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  12. artery disease drugs: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 74 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  13. artery disease outcomes: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  14. artery disease undergoing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  15. artery disease accuracy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  16. artery disease 24-month: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 40 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  17. artery disease assessment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 60 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  18. artery disease increased: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mervyn J. Monteiro 1997-01-01 52 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  19. artery occlusive disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 65 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  20. artery disease stroke: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A; Bachmann, Max O 2011-02-28 72 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  1. artery disease evaluated: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GIUSEPPE, RACHELE 2012-01-01 53 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  2. artery disease insights: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 50 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  3. arterial disease study: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pressure Hielscher, Andreas 8 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  4. arterial disease severity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with chronic Roche, Benjamin 62 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  5. artery disease severity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with chronic Roche, Benjamin 62 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  6. artery disease subanalysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 38 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  7. arterial disease lack: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 42 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  8. ameliorate coral disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Functionally diverse reef-fish communities ameliorate coral disease Biology and Medicine Websites Summary:...

  9. advanced hiv disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HIV-1 infection, with extremes of very rapid disease progression (,2 years) and long-term non-progression (.15 years). To reveal additional host genetic factors that may impact on...

  10. Medicating race : heart disease and durable preoccupations with difference

    E-Print Network [OSTI]

    Pollock, Anne, 1975-

    2007-01-01T23:59:59.000Z

    This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

  11. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan ...........................................................................................................................................................................1 2. The need for regulating IDPs.................................................................................................................................................1 3. General principles of IDP regulation

  12. Striatal origin of the pathologic beta oscillations in Parkinson's disease

    E-Print Network [OSTI]

    Boyden, Edward Stuart

    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

  13. Modelling power-law spread of infectious diseases

    E-Print Network [OSTI]

    Meyer, Sebastian

    2013-01-01T23:59:59.000Z

    Short-time human travel behaviour can be well described by a power law with respect to distance. We incorporate this information in space-time models for infectious disease surveillance data to better capture the dynamics of disease spread. Two previously established model classes are extended, which both decompose disease risk additively into endemic and epidemic components: a space-time point process model for individual point-referenced data, and a multivariate time series model for aggregated count data. In both frameworks, the power-law spread is embedded into the epidemic component and its decay parameter is estimated simultaneously with all other unknown parameters using (penalised) likelihood inference. The performance of the new approach is investigated by a re-analysis of individual cases of invasive meningococcal disease in Germany (2002-2008), and count data on influenza in 140 administrative districts of Southern Germany (2001-2008). In both applications, the power-law formulations substantially ...

  14. A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE

    E-Print Network [OSTI]

    Newton, Billy W.

    2010-01-16T23:59:59.000Z

    Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease and is characterized by the accumulation of fat in the liver. AS is considered clinically benign as it is reversible, as compared with alcoholic...

  15. Human alkaloid biosynthesis : chemical inducers of Parkinson's disease?

    E-Print Network [OSTI]

    Hatzios, Stavroula K. (Stavroula-Artemis K.)

    2005-01-01T23:59:59.000Z

    The occurrence of certain alkaloids in the human brain appears to be associated with the onset of Parkinson's disease (PD). Recently, a human protein bearing homology to an alkaloid synthase in plants was identified. This ...

  16. Real-time Raman system for in vivo disease diagnosis

    E-Print Network [OSTI]

    Motz, Jason T.

    Raman spectroscopy has been well established as a powerful in vitro method for studying biological tissue and diagnosing disease. The recent development of efficient, high-throughput, low-background optical fiber Raman ...

  17. Dopamine Release and Uptake in Animal Models of Neurological Diseases

    E-Print Network [OSTI]

    Fulks, Jenny Lynn

    Fast scan cyclic voltammetry (FSCV) can be utilized to detect neurotransmitter release and uptake in brain slices. When combining this technique with disease state animals models, information for therapeutic targets can ...

  18. Quantitative Neuroimaging : : Applications to Normal Aging and Neurodegenerative Disease

    E-Print Network [OSTI]

    Murphy, Elizabeth Ann

    and metabolism of lipoproteins. Ann Endocrinol 44(1), 59-65.Disease by Elizabeth Ann Murphy Doctor of Philosophy ina tale of two proteins. Ann Neurol. 2006;59(3);449-458.

  19. Huntington's Disease: Can Mice Lead the Way to Treatment?

    E-Print Network [OSTI]

    Crook, Zachary Ryan

    Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and behavioral dysfunctions, such as progressive loss of coordination and memory, and share similar transcriptional profiles and striatal neuron ...

  20. Array-based detection of genetic alterations associated with disease

    DOE Patents [OSTI]

    Pinkel, Daniel; Albertson, Donna G.; Gray, Joe W.

    2007-09-11T23:59:59.000Z

    The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.

  1. A biophysical marker of severity in sickle cell disease

    E-Print Network [OSTI]

    Mahadevan, L.

    The search for predictive indicators of disease has largely focused on molecular markers. However, biophysical markers, which can integrate multiple pathways, may provide a more global picture of pathophysiology. Sickle ...

  2. Educational attainment and rate of cognitive decline in Alzheimer's disease

    E-Print Network [OSTI]

    Hemmy, Laura Sue

    2009-05-15T23:59:59.000Z

    Alzheimer’s disease (AD) progression and hypotheses of the cognitive reserve theory were investigated by testing for a relation between educational attainment and rate of decline in patients with Mild Cognitive Impairment, possible AD, probable AD...

  3. alzheimers disease neuroimaging: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Mathematics Websites...

  4. Timing of testing and treatment for asymptomatic diseases

    SciTech Connect (OSTI)

    K?rk?zlar, Eser [State Univ. of New York (SUNY), Plattsburgh, NY (United States); Faissol, Daniel M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Griffin, Paul M. [Pennsylvania State Univ., State College, PA (United States); Swann, Julie L. [Georgia Inst. of Technology, Atlanta, GA (United States)

    2010-07-01T23:59:59.000Z

    Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision Process (MDP) model for a simple class of asymptomatic diseases in order to provide the building blocks for analysis of a more general class of diseases. We provide a computationally efficient method for determining a cost-effective dynamic intervention strategy that takes into account (i) the results of the previous test for each individual and (ii) the change in the individual’s behavior based on awareness of the disease. We demonstrate the usefulness of the approach by applying the results to screening decisions for Hepatitis C (HCV) using medical data, and compare our findings to current HCV screening recommendations.

  5. 452 Plant Disease / Vol. 82 No. 5 A. R. Biggs

    E-Print Network [OSTI]

    Biggs, Alan R.

    452 Plant Disease / Vol. 82 No. 5 A. R. Biggs West Virginia University, Kearneysville G. G. Grove-illustrated "fact sheets" Dr. Biggs' address is: West Virginia University, University Experiment Farm, P. O. Box 609

  6. Nature of language impairment in motor neurone disease 

    E-Print Network [OSTI]

    Rewaj, Phillipa Jane

    2014-07-01T23:59:59.000Z

    Background: Language impairment associated with Motor Neurone Disease (MND) has been documented since the late 19th century, yet little is understood about the pervasiveness or nature of these deficits. The common clinical ...

  7. acute liver disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    primary biliary cirrhosis (PBC) are progressive autoimmune liver diseases (AiLD) that can lead to liver cirrhosis, hepatic (more) Ngu, Jing Hieng 2013-01-01 3 P ICHAI et al...

  8. RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS

    E-Print Network [OSTI]

    Boyer, Edmond

    RESEARCH OF ANIMAL DISEASE INFORMATION SYSTEM BASED ON GIS TECHNOLOGY Hongbin Wang *, Lin Li, Jing.1007/978-3-642-12220-0_9 #12;2 Hongbin Wang, Lin Li, Jing Dong, Danning Xu, Jing Li distribution. It is evident

  9. Disease Ecology: Community Structure and Pathogen Dynamics [Review

    E-Print Network [OSTI]

    Peterson, A. Townsend

    2007-01-01T23:59:59.000Z

    BOOKS & MEDIA Disease Ecology: Community Structure and Pathogen Dynamics Sharon K. Collinge and Chris Ray, editors Oxford University Press, Cary, North Carolina, 2006 ISBN: 0198567073 Pages: 227; Price: US $124.50 The disciplines of community...

  10. CENTERS FOR DISEASE CONTROL ,,~V'CIl'1I

    E-Print Network [OSTI]

    EXECUTIVESECRETARY Houk, Vernon N., M.D. Director Center for Environmental Health Centers for Disease Conlrol Atlanla Hahnemann UniversilY Broad and Vine Streets Philadelphia, Pennsylvania 19102 Cole, Jerome F., S

  11. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01T23:59:59.000Z

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  12. CORAL HEALTH AND DISEASE: A COMPARISON OF COOK’S AND ‘OPUNOHU BAYS IN MOOREA, FRENCH POLYNESIA

    E-Print Network [OSTI]

    Shea, Alessandra

    2011-01-01T23:59:59.000Z

    Predictive  Modeling  of  Coral  Disease  Distribution Baseline levels of coral disease  in  the  northwestern 2011.   Patterns  of  Coral  Disease  across  Hawaiian 

  13. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08T23:59:59.000Z

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  14. Digital subtraction angiography in pediatric cerebrovascular occlusive disease

    SciTech Connect (OSTI)

    Faerber, E.N.; Griska, L.A.B.; Swartz, J.D.; Capitanio, M.A.; Popky, G.L.

    1984-08-01T23:59:59.000Z

    While conventional angiography has been used to demonstrate cerebrovascular occlusive disease in the past, digital subtraction angiography (DSA) is capable of showing progressive vascular involvement with ease, simplicity, and extremely low morbidity, making it particularly well suited for children and outpatients either alone or coordinated with computed tomography. The authors discuss the usefulness and advantages of DSA as demonstrated in 7 infants and children with hemiplegia, 4 of whom had sickle-cell disease.

  15. Field Diseases of the Sweet Potato in Texas.

    E-Print Network [OSTI]

    Taubenhaus, J. J. (Jacob Joseph)

    1919-01-01T23:59:59.000Z

    TEXAS AGRICULTURAL EXPERIMENT STATION AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS W. B. BIZZELL. President BULLETIN NO. 249 SEPTEMBER, 1919 DIVISION OF PLANT PATHOLOGY AND PHYSIOLOGY FIELD DISEASES OF THE SWEET POTATO IN TEXAS B. YOUNGBLO OD... Medicine. A: & M. College of Texas. 'In cooperatloll with the Unlted States Department of A,mculture. . tIn cooperation with School of Agriculture, A. & M. College of Texas. - BULLETIN NO. 249. SEPTEMBER, 1 919. FIELD DISEASES OF THE SWEET POTATO...

  16. Structural Genomics and Drug Discovery for Infectious Diseases

    SciTech Connect (OSTI)

    Anderson, W.F.

    2010-09-03T23:59:59.000Z

    The application of structural genomics methods and approaches to proteins from organisms causing infectious diseases is making available the three dimensional structures of many proteins that are potential drug targets and laying the groundwork for structure aided drug discovery efforts. There are a number of structural genomics projects with a focus on pathogens that have been initiated worldwide. The Center for Structural Genomics of Infectious Diseases (CSGID) was recently established to apply state-of-the-art high throughput structural biology technologies to the characterization of proteins from the National Institute for Allergy and Infectious Diseases (NIAID) category A-C pathogens and organisms causing emerging, or re-emerging infectious diseases. The target selection process emphasizes potential biomedical benefits. Selected proteins include known drug targets and their homologs, essential enzymes, virulence factors and vaccine candidates. The Center also provides a structure determination service for the infectious disease scientific community. The ultimate goal is to generate a library of structures that are available to the scientific community and can serve as a starting point for further research and structure aided drug discovery for infectious diseases. To achieve this goal, the CSGID will determine protein crystal structures of 400 proteins and protein-ligand complexes using proven, rapid, highly integrated, and cost-effective methods for such determination, primarily by X-ray crystallography. High throughput crystallographic structure determination is greatly aided by frequent, convenient access to high-performance beamlines at third-generation synchrotron X-ray sources.

  17. Non-Chemical Control of Plant Diseases in the Home Garden

    E-Print Network [OSTI]

    Philley, George L.; Kaufman, Harold W.

    2000-02-16T23:59:59.000Z

    Plant diseases can be caused by certain organisms or by environmental factors. This publication discusses non-chemical methods that suppress disease-causing organisms....

  18. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01T23:59:59.000Z

    United States White heart disease mortality rates by gender–year–years of education, ages 25–64 years Heart disease death rate*

  19. Utilization of Fibroblast Steroidogeic Capacity as a Predictive Marker for Alzheimer's Disease

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    the cause of AD must be related to aging · Figure 1. Sex Hormone Dyscrasia Following Menopause Post, including coronary heart disease, stroke, Alzheimer's disease and osteoporosis. Since circulating

  20. Rheumatic Heart Disease and Beta-hemolytic Streptococci in Salvador, Brazil: A Study of Slum Health

    E-Print Network [OSTI]

    Tartof, Sara Yee

    2010-01-01T23:59:59.000Z

    rheumatic fever and rheumatic heart disease in Africa. S Afrthe chain that links the heart to the throat? Lancet Infectchildren with rheumatic heart disease. J Thorac Cardiovasc

  1. Thoracic irradiation in Hodgkin's disease: Disease control and long-term complications

    SciTech Connect (OSTI)

    Tarbell, N.J.; Thompson, L.; Mauch, P. (Harvard Medical School, Boston, MA (USA))

    1990-02-01T23:59:59.000Z

    A total of 590 patients with Stage IA-IIIB Hodgkin's disease received mantle irradiation at the Joint Center for Radiation Therapy between April 1969 and December 1984 as part of their initial treatment. Recurrence patterns as well as pulmonary, cardiac and thyroid complications were analyzed. Pulmonary recurrence was more frequently seen in patients with large mediastinal adenopathy (LMA); 11% of patients with LMA recurred in the lung in contrast to 3.1% with small or no mediastinal disease, p = 0.003. Hilar involvement, when corrected for size of mediastinal involvement, was not predictive of lung relapse. Patients with LMA also had a high rate of nodal relapse above the diaphragm (40%) following radiation therapy (RT) alone as compared to similarly treated patients with small or no mediastinal adenopathy (6.5%), p less than 0.0001. This risk of nodal recurrence was greatly reduced (4.7%) for LMA patients receiving combined radiation therapy and chemotherapy (CMT), p less than 0.0001. Sixty-seven patients (11%) with hilar or large mediastinal involvement received prophylactic, low dose, whole lung irradiation. No decrease in the frequency of lung recurrence was seen with the use of whole lung irradiation. Radiation pneumonitis was seen in 3% of patients receiving radiation therapy alone. In contrast, the use of whole lung irradiation was associated with a 15% risk of pneumonitis, p = 0.006. The risk of pneumonitis was also significantly increased with the use of chemotherapy (11%), p = 0.0001. Cardiac complications were uncommon with pericarditis being the most common complication (2.2%). Thyroid dysfunction was seen in 25% of patients and appeared to be age-related. These data suggest that the long-term complications of mantle irradiation are uncommon with the use of modern radiotherapeutic techniques.

  2. Costs of chronic disease and an alternative to reduce these costs: case study of End Stage Renal Disease (ESRD)

    E-Print Network [OSTI]

    Jang, Won-Ik

    2005-02-17T23:59:59.000Z

    COSTS OF CHRONIC DISEASE AND AN ALTERNATIVE TO REDUCE THESE COSTS: CASE STUDY OF END STAGE RENAL DISEASE (ESRD) A Dissertation by WON-IK JANG Submitted to the Office of Graduate Studies of Texas A&M University in partial...) A Dissertation by WON-IK JANG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved as to style and content by...

  3. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17T23:59:59.000Z

    , & Tennen, 2006). Therefore, HRQOL provides valuable information about patient outcomes in terms of successful adaptation to chronic illness (Livneh, 2001; Varni, Burwinkle, & Lane, 2005). Although HRQOL is a broad concept that may encompass a number...; Cortina, McGraw, deAlarcon, Rothenberg, & Drotar, 2010; Varni et al., 2006; Varni et al., 2007). Within the category of gastrointestinal disorders, Crohn?s disease and ulcerative colitis, two conditions subsumed under the overarching disease category...

  4. Associations of indoor carbon dioxide concentrations, VOCS, environmental susceptibilities with mucous membrane and lower respiratory sick building syndrome symptoms in the BASE study: Analyses of the 100 building dataset

    SciTech Connect (OSTI)

    Apte, M.G.; Erdmann, C.A.

    2002-10-01T23:59:59.000Z

    Using the 100 office-building Building Assessment Survey and Evaluation (BASE) Study dataset, we performed multivariate logistic regression analyses to quantify the associations between indoor minus outdoor CO{sub 2} (dCO{sub 2}) concentrations and mucous membrane (MM) and lower respiratory system (Lresp) Sick Building Syndrome (SBS) symptoms, adjusting for age, sex, smoking status, presence of carpet in workspace, thermal exposure, relative humidity, and a marker for entrained automobile exhaust. Using principal components analysis we identified a number of possible sources of 73 measured volatile organic compounds in the office buildings, and assessed the impact of these VOCs on the probability of presenting the SBS symptoms. Additionally we included analysis adjusting for the risks for predisposition of having SBS symptoms associated with the allergic, asthmatic, and environmentally sensitive subpopulations within the office buildings. Adjusted odds ratios (ORs) for statistically significant, dose-dependant associations (p<0.05) for dry eyes, sore throat, nose/sinus congestion, and wheeze symptoms with 100-ppm increases in dCO{sub 2} ranged from 1.1 to 1.2. These results suggest that increases in the ventilation rates per person among typical office buildings will, on average significantly reduce the prevalence of several SBS symptoms, up to 80%, even when these buildings meet the existing ASHRAE ventilation standards for office buildings. VOC sources were observed to play an role in direct association with mucous membrane and lower respiratory irritation, and possibly to be indirectly involved in indoor chemical reactions with ozone that produce irritating compounds associated with SBS symptoms. O-xylene, possibly emitted from furniture coatings was associated with shortness of breath (OR at the maximum concentration = 8, p < 0.05). The environmental sensitivities of a large subset of the office building population add to the overall risk of SBS symptoms (ORs ranging from 2 to above 11) within the buildings.

  5. Association Between Celiac Disease and Iron Deficiency in Caucasians, but not Non-Caucasians

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    autoimmune gastritis, Helicobacter pylori and celiac diseaserole of celiac disease, helicobacter pylori, and autoimmune

  6. Curr Pharm Des . Author manuscript Bisphosphonates and bone diseases: past, present and future

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    involving excessive bone resorption which include post-menopausal osteoporosis, Paget s disease of bone

  7. Journal of Alzheimer's Disease xx (20xx) xxx DOI 10.3233/JAD-132483

    E-Print Network [OSTI]

    Mandal, Pravat K.

    and Alzheimer's Disease as isoprostanes, neuroprostanes, acrolein, and hydrox- ynonenal (HNE), have also been

  8. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease contributes to the development of coronary heart disease (CHD). Soluble epoxide hydrolase metabolizes as a potential cardiovascular disease- susceptibility gene. INTRODUCTION Coronary heart disease (CHD) is a major

  9. Compositions and Methods for the Treatment of Pierce's Disease

    DOE Patents [OSTI]

    Gupta, Goutam (Santa Fe, NM)

    2008-10-07T23:59:59.000Z

    Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

  10. K. A. Garrett and C. M. Cox. Applied biodiversity science: Managing emerging diseases in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease ecology: The effects of ecosystems on disease and of disease

    E-Print Network [OSTI]

    Garrett, Karen A.

    in agriculture and linked natural systems using 1 ecological principles. Pages 368-386 in Infectious disease in Agriculture and Linked Natural Systems Using Ecological Principles K. A. Garrett and C. M. Cox Summary particular crop species or genotypes are very common. Nonetheless, production agriculture is dominated

  11. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01T23:59:59.000Z

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  12. Review article Aujeszky's disease virus: opportunities and challenges

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Review article Aujeszky's disease virus: opportunities and challenges Federico A. ZUCKERMANN les réponses immunitaires humorale et cellulaire chez le porc ont été mises en évidence. Cet article infection in swine similar to that of herpes simplex virus (HSV) in man. ADV is a neuroinvasive virus

  13. PUBLICATION 600-080 Fish Health and Disease

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    PUBLICATION 600-080 Fish Health and Disease Striped bass (Morone saxitilis) and hybrid striped bass these fish are commonly raised in high densities under intensive aquaculture situations (e.g., cages, ponds of the viral, bacterial, fungal, and parasitic pathogens, but the fish become increasingly susceptible

  14. What college students should know about Meningococcal Disease

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    is relatively rare, occurring at a rate of less than 1 in 100,000 people in the United States. Q. Who is at risk in their throat or nose in a harmless state without developing an illness. Meningococcal bacteria are spread and death within a few hours. Q. How can meningococcal disease be prevented? A. A vaccine is available

  15. Invest in Your Bones Osteoporosis--The Silent Disease

    E-Print Network [OSTI]

    Invest in Your Bones Osteoporosis--The Silent Disease Leaflet 2 Osteoporosis, a painful of State Health Services, 2008). Osteoporosis is preventable and/or treatable. Accordingly, osteoporosis of height, and chronic back pain. Hip fracture, the most serious consequence of osteoporosis, threatens one

  16. Neurobiology of Disease Psychosine Accumulates in Membrane Microdomains in the

    E-Print Network [OSTI]

    Bongarzone, Ernesto R.

    Neurobiology of Disease Psychosine Accumulates in Membrane Microdomains in the Brain of Krabbe of GALC ( -galactosylceramidase) that leads to a progressive accumulation of some galactosyl-sphingolipids in the brain. We hypothesized that the accumulation of psychosine (galactosyl-sphingosine) in the TWI CNS may

  17. Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease

    E-Print Network [OSTI]

    Levenson, Robert W.

    Emotion Regulation Deficits in Frontotemporal Lobar Degeneration and Alzheimer's Disease Madeleine instructed and spontaneous emotion regulation in patients with frontotemporal lobar degeneration (FTLD, N 32) unwarned without instructions to down-regulate, (b) warned without instructions to down-regulate, and (c

  18. Detecting Acromegaly: Screening for Disease with a Morphable Model

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    ridge, and cheek bones. The disease is often missed by physicians and progresses beyond where it might of Blanz and Vetter. The model parameters capture many features of the 3D shape of the subject's head from just a single photograph, and are used directly for classification. We report encouraging results

  19. A Unified Framework for MR Based Disease Classification

    E-Print Network [OSTI]

    Pohl, Kilian M.

    A Unified Framework for MR Based Disease Classification Kilian M. Pohl1,2 and Mert R. Sabuncu2 1-hippocampal gyrus. On this small size data set, our approach, which performs classification based on the MR images with the accuracy achieved by state-of-the-art techniques in schizophrenia MRI research. 1 Introduction Thanks to in

  20. HYGIENIC BEHAVIOR OF HONEY BEES IN RELATION TO CHALKBROOD DISEASE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    HYGIENIC BEHAVIOR OF HONEY BEES IN RELATION TO CHALKBROOD DISEASE Martha GILLIAM, Stephen TABER III classified as resistant or susceptible on the basis of good or poor hygienic behavior, respectively. Colonies colonies that exhibit poor hygienic behavior. Therefore, good hygienic behavior of bees aids in control

  1. Cerebral blood flow in sickle cell cerebrovascular disease

    SciTech Connect (OSTI)

    Huttenlocher, P.R.; Moohr, J.W.; Johns, L.; Brown, F.D.

    1984-05-01T23:59:59.000Z

    Cerebral blood flow (CBF) has been studied by the xenon-133 (/sup 133/Xe) inhalation method in 16 children with suspected sickle cell cerebrovascular disease. Abnormalities consisting of decreases in total, hemispheral, or regional CBF were found in 17 of 26 studies. Eleven studies performed immediately after stroke, transient ischemic attack, or depression of state of alertness showed abnormalities. In addition to confirming regional cerebrovascular insufficiency in children with stroke due to major cerebral artery occlusion, the method detected diffuse decrease in CBF in children with stupor, coma, and seizures who had normal angiographic findings. In contrast, six of seven studies obtained after exchange transfusion or during maintenance on hypertransfusion therapy showed normal findings. The difference between results in patients with acute neurologic disturbances and those receiving transfusion therapy was statistically significant (P less than .005). The data indicate that the /sup 133/Xe method reliably demonstrates cerebrovascular impairment in sickle cell disease. They also suggest that CBF changes in patients with sickle cell disease can be reversed by exchange transfusion and by hypertransfusion therapy. The /sup 133/Xe CBF method may be useful for following up children with sickle cell disease who are at high risk for recurrent stroke.

  2. Botryosphaeriaceae associated with Eucalyptus canker diseases in Colombia

    E-Print Network [OSTI]

    Botryosphaeriaceae associated with Eucalyptus canker diseases in Colombia By C. A. Rodas1,3 , B, Pretoria, 0002, South Africa; 3 Smurfit Carto´n de Colombia, Investigacio´n Forestal, Carrera 3 No. 10-36, Cali, Valle, Colombia. 4 E-mail: bernard.slippers@fabi.up.ac.za (for correspondence) Summary

  3. Cancer is a genetic disease1 . Although environmental

    E-Print Network [OSTI]

    Nowak, Martin A.

    Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

  4. Motor signs predict poor outcomes in Alzheimer disease

    E-Print Network [OSTI]

    ) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 disease (AD). Methods: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State

  5. A Predator-Prey Model with Disease Dynamics Chris Flake

    E-Print Network [OSTI]

    Logan, David

    a diseased fish population and their predators. Analysis of the system is performed to determine among the Tilapia fish of the Salton Sea and their predator, the pelican. This model is of interest deaths not only among the fish themselves, but also in the pelican population. Studies have indicated

  6. Rapid communication Identification of a Crohn's disease specific

    E-Print Network [OSTI]

    Perreault, Jean-Pierre

    to be due to a combination of factors involving diet, genetic background, immunological responses presented antigen, in individuals with a particular genetic back- ground may be involved in the lack that of their respective proteins appear to be useful as specific markers for unequivocally distinguishing Crohn's disease

  7. Selection of a multiple disease resistant runner-type peanut

    E-Print Network [OSTI]

    Baring, Michael Robert

    2007-09-17T23:59:59.000Z

    Four F2:4 populations of peanut (Arachis hypogaea L.) resulting from the complex cross Tamrun 96 X Tx901639-3 X Sun Oleic 95R were grown in three disease nurseries over a 2 year period. Three separate selection techniques were applied to determine...

  8. Introduction The number of catalogued emerging infectious diseases (EIDs), and

    E-Print Network [OSTI]

    Sehgal, Ravinder

    ). Perhaps even more immediate than these other factors are the implications of large- scale deforestation on disease emergence. The global rate of tropical deforestation appears to be increasing readily; between of deforestation in parts of Africa are near 1% per year (FAO, 2009). Deforestation is also increasing in temperate

  9. Food, Poverty and Epidemic Disease, Edinburgh: 1840-1850 

    E-Print Network [OSTI]

    MacGillivray, Neil

    2004-01-01T23:59:59.000Z

    epidemic disease is studied, concentrating on the fever epidemics of 184 1- 44, 1847-49 and the cholera outbreak of 1848-49 but reviewing also the lesser epidemics of measles, whooping cough and scarlet fever. The history of the identification of typhus...

  10. Prediction and Informative Risk Factor Selection of Bone Diseases

    E-Print Network [OSTI]

    Zhang, Aidong

    data and use these integrated features to effectively predict osteoporosis and bone fractures. We; disease memory; osteoporosis; bone fracture. ! 1 INTRODUCTION Risk factor (RF) analysis based on patients on the study of osteoporosis and bone fracture prediction. Over the past few decades, osteoporosis has been

  11. alzheimer disease brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alzheimer disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

  12. alzheimers disease brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alzheimers disease brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Brain MRI segmentation for the...

  13. Random Disease on the Square Grid J ozsef Balogh

    E-Print Network [OSTI]

    Balogh, Jozsef

    a disease process. The initial configuration is called contagious or successful if the corresponding) squares in a contagious configuration. The solution of the initial exercise is the following: Fact. [Folklore] G(n) = n. Proof. If we paint the squares of a diagonal black, it will be a contagious

  14. Structural Location of Disease-associated Single-nucleotide Polymorphisms

    E-Print Network [OSTI]

    Pervouchine, Dmitri D.

    Structural Location of Disease-associated Single-nucleotide Polymorphisms Nathan O. Stitziel1 , Yan-synonymous single-nucleotide polymorphism (nsSNP) of genes introduces amino acid changes to proteins, and plays reserved Keywords: single-nucleotide polymorphism; alpha shape; hidden Markov model; surface pockets

  15. Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data

    E-Print Network [OSTI]

    Li, Jing

    Learning Brain Connectivity of Alzheimer's Disease from Neuroimaging Data Shui Huang2 , Jing Li2 Recent advances in neuroimaging techniques provide great potentials for effective diagnosis of Alzheimer. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds

  16. Prevalence of chronic obstructive pulmonary disease in rural women of

    E-Print Network [OSTI]

    Silver, Whendee

    for refining disease burden assessments attributable to household biomass combustion Priscilla Johnson1 January and May 2007. COPD assessments were done using a combination of clinical examination spend !2 hours/day in the kitchen involved in cooking. Use of solid fuel was associated with higher risk

  17. AT A GLANCE....INSECTS AND DISEASE PROBLEMS THAT SHOULD BE CONSIDERED THIS PEST/DISEASE/CULTURE

    E-Print Network [OSTI]

    Goodman, Robert M.

    /DISEASE/CULTURE JULY 8- JULY 15 HARVEST JULY 15- JULY 22 HARVEST SPOTTED WING DROSOPHILA Lannate, Imidan, Malathion effective against aphids and maggot when possible. Monitor with traps, and use materials that are also effective against aphids and maggot when possible. BLUEBERRY MAGGOT See list from previous newsletter

  18. The Centers for Disease Control and Prevention's Vessel Sanitation Program is proud to bring to you the following

    E-Print Network [OSTI]

    :1189-1197 #12;Mechanisms of Legionella Transmission Showers Humidifiers Cooling towers Respiratory therapy pneumophila · Bacteria growing in cooling tower were introduced in the hotel HVAC system NEJM, 297 equipment Whirlpools Faucets #12;Key Points Regarding Transmission · No person-to-person transmission

  19. Unusual thoracic radiographic findings in children treated for Hodgkin's disease

    SciTech Connect (OSTI)

    Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

    1986-06-01T23:59:59.000Z

    Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

  20. BONE LOSS IN RELATION TO HYPOTHALAMIC ATROPHY IN ALZHEIMER'S DISEASE

    E-Print Network [OSTI]

    Loskutova, Natalia Y.

    2011-05-12T23:59:59.000Z

    considerable burden on the health system, patients, and caregivers. 1.2 Alzheimer’s Disease and Bone Loss Bone health is an important issue in aging and AD. Osteoporosis–related fractures are among the major health and socioeconomic concerns in aging... of bone fractures, and a determining factor in clinical diagnosis of osteoporosis (Ammann and Rizzoli 2003). Several studies in women suggest that low BMD is associated with poorer cognitive function and subsequent cognitive decline (Yaffe, Browner et al...

  1. Programming of cardiovascular disease across the life-course

    E-Print Network [OSTI]

    Blackmore, Heather L.; Ozanne, Susan E.

    2014-12-12T23:59:59.000Z

    is critical in defining an individual’s risk in later life. Left unresolved sub- clinical conditions manifest into diseases such as atherosclerosis, myocardial infarction, stroke and heart failure. Although adverse lifestyle choices in adulthood (poor diet... ]. Maternal protein restriction is one of the most widely studied models of maternal undernutrition and similarly to global caloric restriction, offspring of protein-restricted dams have been shown to have high blood pressure in adulthood [36-39]. However...

  2. Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

    E-Print Network [OSTI]

    Thompson, Paul

    Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19

  3. Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers

    E-Print Network [OSTI]

    Hillerstrom, Hampus

    2008-01-01T23:59:59.000Z

    Alzheimer's disease (AD) is a field with huge unmet need and only a few symptomatic treatments with limited efficacy have been made available to patients. With the testing of disease-modifying drugs in recent years, the ...

  4. I N T H I S I S S U E Lyme disease communication

    E-Print Network [OSTI]

    I N T H I S I S S U E · Lyme disease communication to countryside users · Providing public benefits in private woodlands, causes of wildfires in South Wales and communicating animal disease (Lyme) risks

  5. Morphological, cellular and proteomic features of canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Han, Richard I-Ming

    2009-01-01T23:59:59.000Z

    Myxomatous mitral valve degeneration (MMVD) is the single most common cardiac disease of the dog, and is analogous to Mitral Valve Prolapse in humans. Very little is known about the aetiopathogenesis of this disease or ...

  6. Design of a numerical model for simulation of blood microcirculation and study of sickle cell disease

    E-Print Network [OSTI]

    Le Floch-Yin, François T. (François Thomas)

    2010-01-01T23:59:59.000Z

    Sickle cell disease is nowadays one of the most challenging blood diseases, where patients suffer from both chronic and acute episodes of painful medical conditions. In particular, unpredictable crises due to blood vessel ...

  7. A common allele on chromosome 9 associated with coronary heart disease

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    M. Appleyard, European Heart Journal 3, Suppl H. , H1 (associated with Coronary Heart Disease in whites. Minor9 associated with coronary heart disease Ruth McPherson 1* ,

  8. Fluid and structural modeling of the disease-free and atherosclerotic human carotid bifurcation

    E-Print Network [OSTI]

    Younis, Hesham F. (Hesham Farouk)

    2002-01-01T23:59:59.000Z

    Cardiovascular disease is the leading cause of death in the United States. It claims more lives each year than the next 7 leading causes of death combined. Atherosclerosis is a major cause of cardiovascular disease and is ...

  9. Integrated training in Cardiovascular Diseases Sponsored by the Division of Cardiology

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    and interventional procedures such as percutaneous interventions such as angioplasty and stent placement Knowlton, Division Head I. Major Diseases 1. Coronary artery disease 2. Congestive Heart Failure 3. Cardiac

  10. Di#erential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    , Dublin City University, Dublin 9, Ireland Abstract Aujeszky's Disease virus, (ADV) is a contagious viral Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  11. Micro-Simulations of Infectious Disease using Official Register Data The Case of Smallpox

    E-Print Network [OSTI]

    Boman, Magnus

    , for example. #12;Introduction Should an infection of a contagious disease occur, the potential threat must be seen as an example of a predominantly airborne, fairly contagious vaccine-preventable disease where

  12. Differential equation models for Aujeszky's Disease Virus (ADV) in Irish pig herds

    E-Print Network [OSTI]

    ) is a contagious viral disease that affects the cen- tral nervous system of almost all animals, but swine are its Aladar Aujeszky, when he distinguished psuedorabies from rabies [23]. Aujeszky's Disease is a contagious

  13. asian foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  14. attenuated foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  15. assess foot-and-mouth disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  16. Three surveillance systems for describing the spatial distribution of Johne's disease seropositivity in Texas cattle

    E-Print Network [OSTI]

    Pearce, Brielle H.

    2009-05-15T23:59:59.000Z

    distribution of Johne’s disease seropositvity, based on the three surveillance systems, confirmed our hypothesis that estimation of disease distribution is dependant upon the source of surveillance samples....

  17. Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson’s Disease from Traditional Chinese Medicine

    E-Print Network [OSTI]

    Huang, Hung-Jin

    Dysfunction of ?-glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson’s disease occurrence. Pharmacological chaperone design has been used to ...

  18. Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics

    E-Print Network [OSTI]

    Warren, Andrew David

    With noncommunicable diseases (NCDs) now constituting the majority of global mortality, there is a growing need for low-cost, noninvasive methods to diagnose and treat this class of diseases, especially in resource-limited ...

  19. Research Summary Assessing and communicating animal disease risks for countryside users

    E-Print Network [OSTI]

    to the collection of available leaflets on Lyme disease and to analyse their content mco-supervise a RELU Ph

  20. Proposed measures for the control of three diseases of veterinary public health significance in Bolivia

    E-Print Network [OSTI]

    Justiniano, Mario Miguel

    1981-01-01T23:59:59.000Z

    designed to suppress or eradicate disease has been presented. Plans for the development of effective programs for control of foot-and-mouth disease, brucellosis, and rabies have been presented along with recom- mendations for utilizing a task force... manuscripts of my thesis. TABLE OF CONTENTS Page INTRODUCTION. REVIEW OF THE LITERATURE. Geography Topography. Demography. Livestock Production. 10 Foot-and-Mouth Disease. Veterinary Public Health Aspects of Foot-and-Mouth Disease. 12 Control...

  1. Cardiovascular Disease and Functional Foods: The Effect of Milk Derived Peptides on Hypertension

    E-Print Network [OSTI]

    Nottingham, University of

    1 Cardiovascular Disease and Functional Foods: The Effect of Milk Derived Peptides on Hypertension and Hypertension Cardiovascular disease (CVD) encompasses many conditions including coronary heart disease, heart attack (myocardial infarction), stroke and hypertension. In 2003, CVD accounted for 16.7 million

  2. "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2

    E-Print Network [OSTI]

    Watson, Craig A.

    VM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring on their fish. Typically, "red sore disease" is caused by two organisms, Aeromonas hydrophila , a bacterium

  3. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort

    E-Print Network [OSTI]

    van Geen, Alexander

    13 million residents in the United States.1 Although the International Agency for Research on Cancer Death from cardiovascular disease. Results 198 people died from diseases of circulatory system, accounting for 43% of total mortality in the population. The mortality rate for cardiovascular disease

  4. Machine Learning Algorithms for Predicting Severe Crises of Sickle Cell Disease

    E-Print Network [OSTI]

    Emilion, Richard

    thalassemia, another inherited anemia). The eects of sickle cell disease vary greatly from one personMachine Learning Algorithms for Predicting Severe Crises of Sickle Cell Disease Clara Allayous of an acute splenic sequestration crisis (ASSC), a serious symptom of sickle cell disease (SCD). Precisely

  5. THe heartTruTH Heart disease is the #1 killer of

    E-Print Network [OSTI]

    Baker, Chris I.

    THe heartTruTH® #12;Heart disease is the #1 killer of women, but many women do not know they are at risk. The Heart Truth® campaign aims to give women a personal and urgent wake-up call about their risk of heart disease. The red Dress® is the national symbol for women and heart disease awareness introduced

  6. Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease

    E-Print Network [OSTI]

    Carbonell, Jaime

    Cost-Sensitive Risk Stratification in the Diagnosis of Heart Disease Selen Uguroglu and Jaime Pittsburgh, PA 15212 Abstract We investigate machine learning methods for diagnos- tic screening of heart disease. Coronary heart disease is the leading cause of death in the US, causing more deaths than all

  7. Checklist of Successful Health Plan Approaches to Heart Disease and Stroke Prevention

    E-Print Network [OSTI]

    Checklist of Successful Health Plan Approaches to Heart Disease and Stroke Prevention Yes at risk for heart disease, stroke, and related conditions and risk factors (e.g., routine screenings the health plan offer specialized disease management programs for members who have been diagnosed with heart

  8. Towards an Objective Assessment of Alzheimer's Disease: The Application of a Novel Evolutionary Algorithm

    E-Print Network [OSTI]

    Fernandez, Thomas

    the way out of a large building. It also affects the drawing of simple three- dimensional geometric shapes countries [4]. The disease occurs when the amyloid -protein forms miliary bodies (plaques) and dense bundles conclusions are drawn in Section 5. 2. ALZHEIMER'S DISEASE Alzheimer's disease (AD) is the most common form

  9. Heart . Author manuscript Effects of depressive symptoms and coronary heart disease and their

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Heart . Author manuscript Page /1 11 Effects of depressive symptoms and coronary heart disease separately in patients with coronary heart disease (CHD) and in populations healthy at study inception and CHD status. OBJECTIVE To examine effects of depressive symptoms and coronary heart disease

  10. The Diet-Heart Hypothesis: a critical appraisal of the relationship between diet and coronary artery disease

    E-Print Network [OSTI]

    Jurewitz, Daniel L

    2007-01-01T23:59:59.000Z

    for Prevention of Coronary Heart Disease. JAMA. 2002;288:M. Fish consumption and coronary heart disease mortality: aacid and risk of ischemic heart disease among women. Am J

  11. Congestive heart failure: treat the disease, not the symptom: return to normalcy/Part II--the experimental approach.

    E-Print Network [OSTI]

    Buckberg, Gerald D

    2007-01-01T23:59:59.000Z

    Title: Congestive heart failure: treat the disease not theTITLE: Congestive heart failure: treat the disease not theGD. Congestive heart failure: treat the disease, not the

  12. Glycosyl-phosphatidylinositol (GPI)-anchored membrane association of the porcine reproductive and respiratory syndrome virus GP4 glycoprotein and its co-localization with CD163 in lipid rafts

    SciTech Connect (OSTI)

    Du, Yijun [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States) [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan (China); Pattnaik, Asit K. [School of Veterinary Medicine and Biomedical Sciences and the Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900 (United States)] [School of Veterinary Medicine and Biomedical Sciences and the Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900 (United States); Song, Cheng [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States)] [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Yoo, Dongwan, E-mail: dyoo@illinois.edu [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States)] [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Li, Gang, E-mail: dyoo@illinois.edu [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States) [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Institute of Animal Science and Veterinary Medicine, Chinese Academy of Agricultural Sciences, Beijing (China)

    2012-03-01T23:59:59.000Z

    The porcine reproductive and respiratory syndrome virus (PRRSV) glycoprotein 4 (GP4) resembles a typical type I membrane protein in its structure but lacks a hydrophilic tail at the C-terminus, suggesting that GP4 may be a lipid-anchored membrane protein. Using the human decay-accelerating factor (DAF; CD55), a known glycosyl-phosphatidylinositol (GPI) lipid-anchored protein, chimeric constructs were made to substitute the GPI-anchor domain of DAF with the putative lipid-anchor domain of GP4, and their membrane association and lipase cleavage were determined in cells. The DAF-GP4 fusion protein was transported to the plasma membrane and was cleaved by phosphatidylinositol-specific phospholipase C (PI-PLC), indicating that the C-terminal domain of GP4 functions as a GPI anchor. Mutational studies for residues adjacent to the GPI modification site and characterization of respective mutant viruses generated from infectious cDNA clones show that the ability of GP4 for membrane association corresponded to virus viability and growth characteristics. The residues T158 ({omega} - 2, where {omega} is the GPI moiety at E160), P159 ({omega} - 1), and M162 ({omega} + 2) of GP4 were determined to be important for virus replication, with M162 being of particular importance for virus infectivity. The complete removal of the peptide-anchor domain in GP4 resulted in a complete loss of virus infectivity. The depletion of cholesterol from the plasma membrane of cells reduced the virus production, suggesting a role of lipid rafts in PRRSV infection. Remarkably, GP4 was found to co-localize with CD163 in the lipid rafts on the plasma membrane. Since CD163 has been reported as a cellular receptor for PRRSV and GP4 has been shown to interact with this receptor, our data implicates an important role of lipid rafts during entry of the virus.

  13. Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

    E-Print Network [OSTI]

    Lindquist, Susan

    Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by accumulation of misfolded proteins. Huntington's disease (HD) ...

  14. A Table of Areas Under Disease Progress Curves. 

    E-Print Network [OSTI]

    Johnson, Dennis A.; Wilcoxson, Roy D.

    1980-01-01T23:59:59.000Z

    [Blank Page in Original Bulletin] A TABLE OF AREAS UNDER DISEASE PROGRESS CURVES Technical Bullet in Texas Agricultural Experiment Station Texas A & M University System- [Blank Page in Original Bulletin] A TABLE OF AREAS UNDER D I S E A S E... Chillicothe-Vernon, TX 76384; and Professor Department of Plant Pathology University of Minnesota St. Paul, MN 55108 A T a b l e o f A r e a s Under D i s e a s e P r o g r e s s Curves 3 Denn i s A. J o h n s o n and Roy D . \\ W i l c o x s o...

  15. Sorghum Ergot: New Disease Threat to the Sorghum Industry

    E-Print Network [OSTI]

    Krausz, Joseph P.; Isakeit, Thomas

    1998-07-20T23:59:59.000Z

    of the sorghum ergot pathogen and likely serves as an overwintering source of ergot inoculum in south Texas. E-461 6-98 Sorghum Ergot New Disease Threat to the Sorghum Industry *Extension Plant Pathologists, The Texas A&M University System. Newly formed honeydew... dripping from an infected panicle. Joseph Krausz and Thomas Isakeit* Ho w is it a Threat to Texas? Each f_lo wer infected with ergot represents a direct loss of one seed. Additional losses occur because the stickiness of infected panicles inter- feres...

  16. Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency

    E-Print Network [OSTI]

    Lee, Thomas A.; Krausz, Joseph P.

    2006-04-13T23:59:59.000Z

    Company Rate/acre Diseases Remarks Abound Azoxystrobin Syngenta 6.21?2.3 oz Scab, anthracnose Maximum 1.16 qt/year. No more than 3 applications before switching fungicides. 7?21-day interval Sovran Kresoxim-methyl BASF Pre... 30 oz/season. Trifl oxystrobin No more than 3 applications at a time before alternating. 14- to 21-day interval Headline Pyraclostrobin BASF 6?7 oz/A Scab Maximum 4 applications/ season or max of 28 oz/ season...

  17. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25T23:59:59.000Z

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  18. Chronic Beryllium Disease Prevention Program (10 CFR 850) | Department of

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T, Inc.'sEnergyTexas1. Feedstock &Energy Chronic Beryllium Disease

  19. Heart DiseaseHeart Disease--Learn to Love YourLearn to Love Your Michael McKee, M.D.Michael McKee, M.D.

    E-Print Network [OSTI]

    Goldman, Steven A.

    Heart DiseaseHeart Disease-- Learn to Love YourLearn to Love Your HeartHeart Michael McKee, M.D.Michael McKee, M.D. March 19, 2010March 19, 2010 #12;GoalsGoals ·· Learn more about heart disease for yourself andLearn more about heart disease for yourself and for your studentsfor your students ·· Learn

  20. Bead-based microfluidic immunoassay for diagnosis of Johne's disease

    SciTech Connect (OSTI)

    Wadhwa, Ashutosh [University of Tennessee, Center for Wildlife Health, Department of Forestry; Foote, Robert [ORNL; Shaw, Robert W [ORNL; Eda, Shigetoshi [ORNL

    2012-01-01T23:59:59.000Z

    Microfluidics technology offers a platform for development of point-of-care diagnostic devices for various infectious diseases. In this study, we examined whether serodiagnosis of Johne s disease (JD) can be conducted in a bead-based microfluidic assay system. Magnetic micro-beads were coated with antigens of the causative agent of JD, Mycobacterium avium subsp. paratuberculosis. The antigen-coated beads were incubated with serum samples of JD-positive or negative serum samples and then with a fluorescently-labeled secondary antibody (SAB). To confirm binding of serum antibodies to the antigen, the beads were subjected to flow cytometric analysis. Different conditions (dilutions of serum and SAB, types of SAB, and types of magnetic beads) were optimized for a great degree of differentiation between the JD-negative and JD-positive samples. Using the optimized conditions, we tested a well-classified set of 155 serum samples from JD negative and JD-positive cattle by using the bead-based flow cytometric assay. Of 105 JD-positive samples, 63 samples (60%) showed higher antibody binding levels than a cut-off value determined by using antibody binding levels of JD-negative samples. In contrast, only 43-49 JD-positive samples showed higher antibody binding levels than the cut-off value when the samples were tested by commercially-available immunoassays. Microfluidic assays were performed by magnetically immobilizing a number of beads within a microchannel of a glass microchip and detecting antibody on the collected beads by laser-induced fluorescence. Antigen-coated magnetic beads treated with bovine serum sample and fluorescently-labeled SAB were loaded into a microchannel to measure the fluorescence (reflecting level of antibody binding) on the beads in the microfluidic system. When the results of five bovine serum samples obtained with the system were compared to those obtained with the flow cytometer, a high level of correlation (linear regression, r2 = 0.994) was observed. In a further experiment, we magnetically immobilized antigen-coated beads in a microchannel, reacted the beads with serum and SAB in the channel, and detected antibody binding to the beads in the microfluidic system. A strong antibody binding in JD-positive serum was detected, whereas there was only negligible binding in negative control experiments. Our data suggest that the bead-based microfluidic system may form a basis for development of an on-site serodiagnosis of JD. Key Words: Mycobacterium avium ssp. paratuberculosis, Johne s disease, microfluidics, lab-on-a-chip.

  1. Bisphosphonates and Bone diseases: past, present and future Bisphosphonates are stable analogues of the naturally-occuring inorganic

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    involving excessive bone resorption which include post-menopausal osteoporosis, Paget's disease of bone

  2. When you hear the term "heart disease," what's your first reaction? Like many women, you may think, "That's a

    E-Print Network [OSTI]

    Bandettini, Peter A.

    When you hear the term "heart disease," what's your first reaction? Like many women, you may think, "That's a man's disease." But here's The Heart Truth: Heart disease is the #1 killer of Latinas in the United States. Together with stroke, heart disease accounts for a third of all deaths among Latinas

  3. When you hear the term "heart disease," what is your first reaction? Like many women, you may think, "That's a

    E-Print Network [OSTI]

    Bandettini, Peter A.

    When you hear the term "heart disease," what is your first reaction? Like many women, you may think, "That's a man's disease." But here's The Heart Truth: Heart disease is the #1 killer of women in the United States. It is also a leading cause of disability among women. If you've got a heart, heart disease

  4. A Table of Areas Under Disease Progress Curves.

    E-Print Network [OSTI]

    Johnson, Dennis A.; Wilcoxson, Roy D.

    1980-01-01T23:59:59.000Z

    o n s d a r i n g t h e development o f t h e ep idemic . The v a l u e s f o r AUDPC a r e l i s t e d under t h e days between t h e o b s e r v a t i o n s o f d i s e a s e . Thus , from d i s e a s e s e v e r i t i e s t a... a i d o f t h e m o d i f i e d c o b b Scale (12). The rus t sever i tyda tawere converted Fig. 2 Disease Progress Curves of Three Winter Wheat Cultivars Infected with Puccinia recondita f. sp. tritici. - TAM W-101 - - - I 1 A 0 ~ i m e...

  5. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01T23:59:59.000Z

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  6. Winter Infections: Influenza, Respiratory Syncytial Virus (RSV)

    E-Print Network [OSTI]

    Goldman, Steven A.

    spread? Sick person can spread influenza by: ­ Touching ­ Sneezing ­ Coughing Picture: newbedfordguide Fever Cough Fatigue (feel "worn out") Headaches Body aches Runny nose #12;Influenza ("Flu") Treatments paralysis) #12;"MythBusters" Reported That: Sneezes can travel ~35 mph Cough/sneeze droplets can travel

  7. Respiratory Protection Program | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin ofEnergy at Waste-to-Energy usingof Enhanced Dr. JuliaPOINT OF CONTACTRespiratory

  8. Hanford Site Respiratory Protection Program (HSRPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cn SunnybankD.jpgHanford LEED&soil Hanford Traffic Department of

  9. Neurological Complications Following Endoluminal Repair of Thoracic Aortic Disease

    SciTech Connect (OSTI)

    Morales, J. P.; Taylor, P. R.; Bell, R. E.; Chan, Y. C. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Sabharwal, T. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom); Carrell, T. W. G. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Reidy, J. F. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom)], E-mail: John.Reidy@gstt.nhs.uk

    2007-09-15T23:59:59.000Z

    Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.

  10. Dual-Energy CT Angiography in Peripheral Arterial Occlusive Disease

    SciTech Connect (OSTI)

    Brockmann, Carolin, E-mail: carolin.brockmann@rad.ma.uni-heidelberg.de; Jochum, Susanne; Sadick, Maliha [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany); Huck, Kurt [University of Heidelberg, I. Medical Clinic, Medical Faculty Mannheim (Germany); Ziegler, Peter [University of Heidelberg, Department of Surgery, Medical Faculty Mannheim (Germany); Fink, Christian; Schoenberg, Stefan O.; Diehl, Steffen J. [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany)

    2009-07-15T23:59:59.000Z

    We sought to study the accuracy of dual-energy computed tomographic angiography (DE-CTA) for the assessment of symptomatic peripheral arterial occlusive disease of the lower extremity by using the dual-energy bone removal technique compared with a commercially available conventional bone removal tool. Twenty patients underwent selective digital subtraction angiography and DE-CTA of the pelvis and lower extremities. CTA data were postprocessed with two different applications: conventional bone removal and dual-energy bone removal. All data were reconstructed and evaluated as 3D maximum-intensity projections. Time requirements for reconstruction were documented. Sensitivity, specificity, accuracy, and concordance of DE-CTA regarding degree of stenosis and vessel wall calcification were calculated. A total of 359 vascular segments were analyzed. Compared with digital subtraction angiography, sensitivity, specificity, and accuracy, respectively, of CTA was 97.2%, 94.1%, and 94.7% by the dual-energy bone removal technique. The conventional bone removal tool delivered a sensitivity of 77.1%, a specificity of 70.7%, and an accuracy of 72.0%. Best results for both postprocessing methods were achieved in the vascular segments of the upper leg. In severely calcified segments, sensitivity, specificity, and accuracy stayed above 90% by the dual-energy bone removal technique, whereas the conventional bone removal technique showed a substantial decrease of sensitivity, specificity, and accuracy. DE-CTA is a feasible and accurate diagnostic method in the assessment of symptomatic peripheral arterial occlusive disease. Results obtained by DE-CTA are superior to the conventional bone removal technique and less dependent on vessel wall calcifications.

  11. Standardization of a Pan-Specific Test for the Diagnosis of Lyme Disease in Veterinary Medicine 

    E-Print Network [OSTI]

    Mcgregor, Erin 1990-

    2012-04-30T23:59:59.000Z

    for the designation as UNDERGRADUATE RESEARCH SCHOLAR A Senior Scholars Thesis by ERIN MCGREGOR STANDARDIZATION OF A PAN-SPECIFIC TEST FOR THE DIAGNOSIS OF LYME DISEASE IN VETERINARY MEDICINE Approved by: Research Advisor: Maria... of Veterinary Medicine and Biomedical Sciences Texas A&M University Research Advisor: Dr. Maria Esteve-Gassent Department of Veterinary Pathobiology Lyme disease (LD) is the most prevalent tick borne disease in the US with a total of 22,572 confirmed...

  12. Characterization of the Meq oncoproteins of Marek's disease virus vaccine strain CVI988/Rispens

    E-Print Network [OSTI]

    Ajithdoss, Dharani K.

    2010-07-14T23:59:59.000Z

    the condition in four adult male chickens in 1907 (Biggs, 1961; Marek, 1907). He described the disease as a "polyneuritis" or a ?neuritis interstitialis?, characterized by paralysis of the legs and wings. Grossly, the sacral plexuses and spinal cords were... leukosis virus (Biggs, 1961; Campbel, 1961; Elermann, 1922). Based on susceptibility, organs afected, and histopathogenesis, the disease can be distinguished from lymphoid leucosis and a new name, Marek?s disease, was proposed (Biggs, 1961). Later...

  13. E-Print Network 3.0 - aggravated creutzfeldt-jacob disease Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Proteins are the workhorses of the body, and the enigmatic process... secrets of protein folding that could lead to improved diagnosis and treatment of diseases Source: Daggett,...

  14. Soil fungicides in relation to cotton seedling disease at various temperature levels

    E-Print Network [OSTI]

    Ranney, Carleton David

    1955-01-01T23:59:59.000Z

    to obtain controlled spacing an4 4epth of seed ?hon ylanting, ~, , ~ 18 Xllnotration of seedling disease grades. Xi No evidence of diseases' energed 2 Sprouted' no e?L'donee of disease; no ssLergenoe. 5 Lesion less than three nao in length? 4i Lesion... of disease. 2, Emerged; lesion lees than three nn. long. ~Eaepgedj le&oh learn Qlall I%a ss, 10$$, gl aineb io the non proprietary nano ef sino ?thglene bi sdithiooarhanate. 4. Knerged~ sevorelF lesiono4, but not girdle4. 5? Energed~ dea4 or girdling...

  15. Gist Memory in Alzheimer's Disease: Evidence From Categorized Pictures Andrew E. Budson

    E-Print Network [OSTI]

    Schacter, Daniel

    Gist Memory in Alzheimer's Disease: Evidence From Categorized Pictures Andrew E. Budson Edith of items (gist memory; Reyna & Brainerd, 1995; Schacter, Norman, & Koutstaal, 1998). We have argued

  16. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  17. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  18. Edge effects, not connectivity, determine the incidence and development of a foliar fungal plant disease.

    SciTech Connect (OSTI)

    Johnson, Brenda, L.; Haddad, Nick, M.

    2011-08-01T23:59:59.000Z

    Using a model plant-pathogen system in a large-scale habitat corridor experiment, we found that corridors do not facilitate the movement of wind-dispersed plant pathogens, that connectivity of patches does not enhance levels of foliar fungal plant disease, and that edge effects are the key drivers of plant disease dynamics. Increased spread of infectious disease is often cited as a potential negative effect of habitat corridors used in conservation, but the impacts of corridors on pathogen movement have never been tested empirically. Using sweet corn (Zea mays) and southern corn leaf blight (Cochliobolus heterostrophus) as a model plant-pathogen system, we tested the impacts of connectivity and habitat fragmentation on pathogen movement and disease development at the Savannah River Site, South Carolina, USA. Over time, less edgy patches had higher proportions of diseased plants, and distance of host plants to habitat edges was the greatest determinant of disease development. Variation in average daytime temperatures provided a possible mechanism for these disease patterns. Our results show that worries over the potentially harmful effects of conservation corridors on disease dynamics are misplaced, and that, in a conservation context, many diseases can be better managed by mitigating edge effects.

  19. Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

    E-Print Network [OSTI]

    2014-01-01T23:59:59.000Z

    Integrative Genomics Reveals Novel Molecular Pathways and7 | e1004502 Integrative Genomics of Coronary Artery Disease2012) Use of functional genomics to identify candidate genes

  20. Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study

    E-Print Network [OSTI]

    von Mühlen, D.; Allison, M.; Jassal, S. K.; Barrett-Connor, E.

    2009-01-01T23:59:59.000Z

    calcification and the risk of osteoporosis and fractures. Jarterial disease and osteoporosis in older adults: theassociation between PAD and osteoporosis and bone loss only