National Library of Energy BETA

Sample records for reporting interstitial therapy

  1. BERAC Subcommittee Report on Boron Neutron Capture Therapy (BNCT...

    Office of Science (SC) Website

    BERAC Subcommittee Report on Boron Neutron Capture Therapy (BNCT) Clinical Trials. ... ChargesReports BERAC Subcommittee Report on Boron Neutron Capture Therapy (BNCT) Clinical ...

  2. Periodontium destruction associated with oncology therapy. Five case reports

    SciTech Connect (OSTI)

    Wright, W.E.

    1987-08-01

    Radiation treatment to the head and neck and cytotoxic chemotherapy can produce deleterious side effects to the periodontium that are generally transient in nature, reversible, and do not result in permanently visible defects. However, combinations of the malignant disease itself, the direct and indirect effects of medical therapy and associated oral infections, along with local trauma can lead to periodontal tissue destruction with resulting permanent architectural defects. Five case reports illustrate destructive alterations of the periodontium that were associated with oncology therapy. Proposed guidelines for periodontal treatment of compromised individuals undergoing oncology therapies are suggested.

  3. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect (OSTI)

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  4. Migration mechanisms of oxygen interstitial cluste (Journal Article) |

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Migration mechanisms of oxygen interstitial cluste Citation Details In-Document Search Title: Migration mechanisms of oxygen interstitial cluste Understanding the migration kinetics of radiation- Authors: Xian-Ming Bai ; Anter El-Azab ; Jianguo Yu ; Todd R. Publication Date: 2013-01-01 OSTI Identifier: 1083247 Report Number(s): INL/JOU-13-29349 DOE Contract Number: DE-AC07-05ID14517 Resource Type: Journal Article Resource Relation: Journal Name: Journal of Physics: Condensed

  5. DFT STUDY REVISES INTERSTITIAL CONFIGURATIONS IN HCP Zr

    SciTech Connect (OSTI)

    Samolyuk, German D; Golubov, Stanislav I; Osetskiy, Yury N; Stoller, Roger E

    2012-06-01

    Analysis of experimental result on microstructure evolution in irradiated Zr and alloys has demonstrated that available knowledge on self-interstitial defects in Zr is in contradiction. We therefore have initiated an extensive theoretical and modeling program to clarify this issue. In this report we present first ab initio calculations results of single SIA configurations in Zr. We demonstrate importance of simulations cell size, applied exchange-correlation functional and simulated c/a ratio. The results obtained demonstrate clearly that the most stable configurations are in basal plane and provide some evidences for enhanced interstitial transport along basal planes. The results obtained will be used in generation a new interatomic potential for Zr to be used in large-scale atomistic modeling of mechanisms relevant for radiation-induced microstructure evolution.

  6. Bolus electron conformal therapy for the treatment of recurrent inflammatory breast cancer: a case report

    SciTech Connect (OSTI)

    Kim, Michelle M.; Kudchadker, Rajat J.; Kanke, James E.; Zhang, Sean; Perkins, George H.

    2012-07-01

    The treatment of locoregionally recurrent breast cancer in patients who have previously undergone radiation therapy is challenging. Special techniques are often required that both eradicate the disease and minimize the risks of retreatment. We report the case of a patient with an early-stage left breast cancer who developed inflammatory-type recurrence requiring re-irradiation of the chest wall using bolus electron conformal therapy with image-guided treatment delivery. The patient was a 51-year-old woman who had undergone lumpectomy, axillary lymph node dissection, and adjuvant whole-breast radiation therapy for a stage I left breast cancer in June 1998. In March 2009, she presented at our institution with biopsy-proven recurrent inflammatory carcinoma and was aggressively treated with multi-agent chemotherapy followed by mastectomy that left a positive surgical margin. Given the patient's prior irradiation and irregular chest wall anatomy, bolus electron conformal therapy was used to treat her chest wall and draining lymphatics while sparing the underlying soft tissue. The patient still had no evidence of disease 21 months after treatment. Our results indicate that bolus electron conformal therapy is an accessible, effective radiation treatment approach for recurrent breast cancer in patients with irregular chest wall anatomy as a result of surgery. This approach may complement standard techniques used to reduce locoregional recurrence in the postmastectomy setting.

  7. Di-interstitial defect in silicon revisited

    SciTech Connect (OSTI)

    Londos, C. A.; Antonaras, G.; Chroneos, A.; Department of Materials, Imperial College London, London SW7 2BP

    2013-11-21

    Infrared spectroscopy was used to study the defect spectrum of Cz-Si samples following fast neutron irradiation. We mainly focus on the band at 533 cm{sup ?1}, which disappears from the spectra at ?170 C, exhibiting similar thermal stability with the Si-P6 electron paramagnetic resonance (EPR) spectrum previously correlated with the di-interstitial defect. The suggested structural model of this defect comprises of two self-interstitial atoms located symmetrically around a lattice site Si atom. The band anneals out following a first-order kinetics with an activation energy of 0.88 0.3 eV. This value does not deviate considerably from previously quoted experimental and theoretical values for the di-interstitial defect. The present results indicate that the 533 cm{sup ?1} IR band originates from the same structure as that of the Si-P6 EPR spectrum.

  8. Impact of interstitial oxygen on the electronic and magnetic...

    Office of Scientific and Technical Information (OSTI)

    interstitial oxygen on the electronic and magnetic structure in superconducting Fe 1 + y Te O x thin films Citation Details In-Document Search Title: Impact of interstitial oxygen...

  9. Influence of interstitial Mn on magnetism in room-temperature ferromagnet Mn(1+delta)Sb

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Taylor, Alice E; Berlijn, Tom; Hahn, Steven E; May, Andrew F; Williams, Travis J; Poudel, Lekhanath N; Calder, Stuart A; Fishman, Randy Scott; Stone, Matthew B; Aczel, Adam A; et al

    2015-01-01

    We report elastic and inelastic neutron scattering measurements of the high-TC ferromagnet Mn(1+delta)Sb. Measurements were performed on a large, TC = 434 K, single crystal with interstitial Mn content of delta=0.13. The neutron diffraction results reveal that the interstitial Mn has a magnetic moment, and that it is aligned antiparallel to the main Mn moment. We perform density functional theory calculations including the interstitial Mn, and find the interstitial to be magnetic in agreement with the diffraction data. The inelastic neutron scattering measurements reveal two features in the magnetic dynamics: i) a spin-wave-like dispersion emanating from ferromagnetic Bragg positions (Hmore » K 2n), and ii) a broad, non-dispersive signal centered at forbidden Bragg positions (H K 2n+1). The inelastic spectrum cannot be modeled by simple linear spin-wave theory calculations, and appears to be significantly altered by the presence of the interstitial Mn ions. The results show that the influence of the int« less

  10. Influence of interstitial Mn on magnetism in room-temperature ferromagnet Mn(1+delta)Sb

    SciTech Connect (OSTI)

    Taylor, Alice E; Berlijn, Tom; Hahn, Steven E; May, Andrew F; Williams, Travis J; Poudel, Lekhanath N; Calder, Stuart A; Fishman, Randy Scott; Stone, Matthew B; Aczel, Adam A; Cao, Huibo; Lumsden, Mark D; Christianson, Andrew D

    2015-01-01

    We report elastic and inelastic neutron scattering measurements of the high-TC ferromagnet Mn(1+delta)Sb. Measurements were performed on a large, TC = 434 K, single crystal with interstitial Mn content of delta=0.13. The neutron diffraction results reveal that the interstitial Mn has a magnetic moment, and that it is aligned antiparallel to the main Mn moment. We perform density functional theory calculations including the interstitial Mn, and find the interstitial to be magnetic in agreement with the diffraction data. The inelastic neutron scattering measurements reveal two features in the magnetic dynamics: i) a spin-wave-like dispersion emanating from ferromagnetic Bragg positions (H K 2n), and ii) a broad, non-dispersive signal centered at forbidden Bragg positions (H K 2n+1). The inelastic spectrum cannot be modeled by simple linear spin-wave theory calculations, and appears to be significantly altered by the presence of the interstitial Mn ions. The results show that the influence of the int

  11. Bistability of Cation Interstitials in II-VI Semiconductors

    SciTech Connect (OSTI)

    Wei, S. H.; Dalpian, G. M.

    2005-11-01

    The stability of cation interstitials in II-VI semiconductors is studied using ab initio methods. We find that interstitials in the neutral charge state are more stable in the tetrahedral interstitial site near the cation, whereas in the (2+) charge state, they are more stable near the anion. The diffusion energy barrier changes when the defect charge state changes. Therefore, if electrons/holes are taken from the defect level by light, changing its charge state, the interstitial atom will be able to diffuse almost spontaneously due to a reduced diffusion barrier.

  12. Self-Reported Cognitive Outcomes in Patients With Brain Metastases Before and After Radiation Therapy

    SciTech Connect (OSTI)

    Cole, Ansa Maer; Scherwath, Angela; Ernst, Gundula; Lanfermann, Heinrich; Bremer, Michael; Steinmann, Diana

    2013-11-15

    Purpose: Patients with brain metastases may experience treatment-related cognitive deficits. In this study, we prospectively assessed the self-reported cognitive abilities of patients with brain metastases from any solid primary cancer before and after irradiation of the brain. Methods and Materials: The treatment group (TG) consisted of adult patients (n=50) with brain metastases who received whole or partial irradiation of the brain without having received prior radiation therapy (RT). The control group (CG) consisted of breast cancer patients (n=27) without cranial involvement who were treated with adjuvant RT. Patients were recruited between May 2008 and December 2010. Self-reported cognitive abilities were acquired before RT and 6 weeks, 3 months, and 6 months after irradiation. The information regarding the neurocognitive status was collected by use of the German questionnaires for self-perceived deficits in attention (FEDA) and subjectively experienced everyday memory performance (FEAG). Results: The baseline data showed a high proportion of self-perceived neurocognitive deficits in both groups. A comparison between the TG and the CG regarding the course of self-reported outcomes after RT showed significant between-group differences for the FEDA scales 2 and 3: fatigue and retardation of daily living activities (P=.002) and decrease in motivation (P=.032) with an increase of attention deficits in the TG, but not in the CG. There was a trend towards significance in FEDA scale 1: distractibility and retardation of mental processes (P=.059) between the TG and the CG. The FEAG assessment presented no significant differences. An additional subgroup analysis within the TG was carried out. FEDA scale 3 showed significant differences in the time-related progress between patients with whole-brain RT and those receiving hypofractionated stereotactic RT (P=.025), with less decrease in motivation in the latter group. Conclusion: Self-reported attention declined in patients with brain metastases after RT to the brain, whereas it remained relatively stable in breast cancer patients.

  13. Friedel-Like Oscillations from Interstitial Iron in Superconducting

    Office of Scientific and Technical Information (OSTI)

    Fe1+yTe0.62Se0.38 (Journal Article) | SciTech Connect Journal Article: Friedel-Like Oscillations from Interstitial Iron in Superconducting Fe1+yTe0.62Se0.38 Citation Details In-Document Search Title: Friedel-Like Oscillations from Interstitial Iron in Superconducting Fe1+yTe0.62Se0.38 Using polarized and unpolarized neutron scattering we show that interstitial Fe in superconducting Fe$$_{1+y}$$Te$$_{1-x}$$Se$_x$ induces a magnetic Friedel-like oscillation that diffracts at $${\bf

  14. Friedel-Like Oscillations from Interstitial Iron in Superconducting...

    Office of Scientific and Technical Information (OSTI)

    A semi-metallic 5-band model with (frac12frac12) Fermi surface nesting and four fold symmetric super-exchange between interstitial Fe and two in-plane nearest ...

  15. Complexes of self-interstitials with oxygen atoms in Ge

    SciTech Connect (OSTI)

    Khirunenko, L. I.; Pomozov, Yu. V.; Sosnin, M. G.; Abrosimov, N. V.; Riemann, H.

    2014-02-21

    Interactions of germanium self-interstitials with interstitial oxygen atoms in Ge subjected to irradiation at ?80 K and subsequently to annealing have been studied. To distinguish the processes involving vacancies and self-interstitials the doping with tin was used. It was shown that absorption lines with maximum at 602, 674, 713 and 803 cm{sup ?1} are self-interstitials-related. Two lines at 602 and 674, which develop upon annealing in the temperature range 180240 K, belong to IO complexes, while the bands at 713 and 803 cm{sup ?1}, which emerge after annealing at T>220 K, are associated with I{sub 2}O. It is argued that the annealing of IO occurs by two mechanisms: by dissociation and by diffusion.

  16. First-principles studies on vacancy-modified interstitial diffusion

    Office of Scientific and Technical Information (OSTI)

    mechanism of oxygen in nickel, associated with large-scale atomic simulation techniques (Journal Article) | SciTech Connect First-principles studies on vacancy-modified interstitial diffusion mechanism of oxygen in nickel, associated with large-scale atomic simulation techniques Citation Details In-Document Search Title: First-principles studies on vacancy-modified interstitial diffusion mechanism of oxygen in nickel, associated with large-scale atomic simulation techniques Authors: Fang, H

  17. Hydrogen passivation of interstitial iron in boron-doped multicrystalline silicon during annealing

    SciTech Connect (OSTI)

    Liu, AnYao; Sun, Chang; Macdonald, Daniel

    2014-11-21

    Effective hydrogenation of interstitial iron in boron-doped multicrystalline silicon wafers is reported. The multicrystalline silicon wafers were annealed with plasma-enhanced chemical vapour deposited silicon nitride films, at temperatures of 400?C??900?C and for times from minutes to hours. At low temperatures where a combined effect of hydrogenation and precipitation of dissolved Fe is expected, results show that the hydrogenation process dominates the effect of precipitation. The concentrations of dissolved interstitial iron reduce by more than 90% after a 30-min anneal at temperatures between 600 and 900?C. The most effective reduction occurs at 700?C, where 99% of the initial dissolved iron is hydrogenated after 30?min. The results show that the observed reductions in interstitial Fe concentrations are not caused by the internal gettering of Fe at structural defects or by an enhanced diffusivity of Fe due to the presence of hydrogen. The hydrogenation process is conjectured to be the pairing of positively charged iron with negatively charged hydrogen, forming less recombination active Fe-H complexes in silicon.

  18. Final Report for the “WSU Neutron Capture Therapy Facility Support”

    SciTech Connect (OSTI)

    Gerald E. Tripard; Keith G. Fox

    2006-08-24

    The objective for the cooperative research program for which this report has been written was to provide separate NCT facility user support for the students, faculty and scientists who would be doing the U.S. Department of Energy Office (DOE) of Science supported advanced radiotargeted research at the WSU 1 megawatt TRIGA reactor. The participants were the Idaho National laboratory (INL, P.I., Dave Nigg), the Veterinary Medical Research Center of Washington State University (WSU, Janean Fidel and Patrick Gavin), and the Washington State University Nuclear Radiation Center (WSU, P.I., Gerald Tripard). A significant number of DOE supported modifications were made to the WSU reactor in order to create an epithermal neutron beam while at the same time maintaining the other activities of the 1 MW reactor. These modifications were: (1) Removal of the old thermal column. (2) Construction and insertion of a new epithermal filter, collimator and shield. (3) Construction of a shielded room that could accommodate the very high radiation field created by an intense neutron beam. (4) Removal of the previous reactor core fuel cluster arrangement. (5) Design and loading of the new reactor core fuel cluster arrangement in order to optimize the neutron flux entering the epithermal neutron filter. (6) The integration of the shielded rooms interlocks and radiological controls into the SCRAM chain and operating electronics of the reactor. (7) Construction of a motorized mechanism for moving and remotely controlling the position of the entire reactor bridge. (8) The integration of the reactor bridge control electronics into the SCRAM chain and operating electronics of the reactor. (9) The design, construction and attachment to the support structure of the reactor of an irradiation box that could be inserted into position next to the face of the reactor. (Necessitated by the previously mentioned core rearrangement). All of the above modifications were successfully completed and tested. The resulting epithermal beam of 1 x 10{sup 9} n/sec-cm{sup 2} was measured by Idaho National Laboratory with assistance from WSU's Neutron Activation Analysis Group. The beam is as good as our initial proposals for the project had predicted. In addition to all of the design, construction and insertion of the hardware, shielding, electronics and radiation monitoring systems there was considerable manpower and effort put into changes in the Technical Specifications of the reactor and implementing procedures for use of the new facility. This staff involvement is one of the reasons we requested special facility support from the DOE. Once the facility was competed and all of the recalibrations and measurements made to characterize the differences between this reactor core and the previous core we began to assist INL in making their beam measurements with foils and phantoms. Although we proposed support for only one additional staff position to support this new NCT facility the staff support provided by the WSU Nuclear Radiation Center was greater than had been anticipated by our initial proposal. INL was also assisted in the testing of a heavy water (deuterated water) bladder that can be inserted into the collimator in order to produce an intense, external thermal neutron beam. The external epithermal and/or thermal neutron beam capability remains available for use, if funding becomes available for future research projects.

  19. Surprising stability of neutral interstitial hydrogen in diamond and cubic BN

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lyons, J. L.; Van de Walle, C. G.

    2016-01-21

    We report that in virtually all semiconductors and insulators, hydrogen interstitials (Hi) act as negative-U centers, implying that hydrogen is never stable in the neutral charge state. Using hybrid density functional calculations, we find a different behavior for Hi in diamond and cubic BN. In diamond, Hi is a very strong positive-U center, and the H0icharge state is stable over a Fermi-level range of more than 2 eV. In cubic BN, a III-V compound similar to diamond, we also find positive-U behavior, though over a much smaller Fermi-level range. Finally, these results highlight the unique behavior of Hi in thesemore » covalent wide-band-gap semiconductors.« less

  20. Outcomes of High-Dose-Rate Interstitial Brachytherapy in the Treatment of Locally Advanced Cervical Cancer: Long-term Results

    SciTech Connect (OSTI)

    Pinn-Bingham, Melva; Puthawala, Ajmel A.; Syed, A.M. Nisar; Sharma, Anil; DiSaia, Philip; Berman, Michael; Tewari, Krishnansu S.; Randall-Whitis, Leslie; Mahmood, Usama; Ramsinghani, Nilam; Kuo, Jeffrey; Chen, Wen-Pin; McLaren, Christine E.

    2013-03-01

    Purpose: The purpose of this study was to determine locoregional control (LRC), disease-free survival (DFS), and toxicity of high-dose-rate interstitial brachytherapy (HDR-ISBT) in the treatment of locally advanced cervical cancer. Methods and Materials: Between March 1996 and May 2009, 116 patients with cervical cancer were treated. Of these, 106 (91%) patients had advanced disease (International Federation of Gynecology and Obstetrics stage IIB-IVA). Ten patients had stage IB, 48 had stage II, 51 had stage III, and 7 had stage IVA disease. All patients were treated with a combination of external beam radiation therapy (EBRT) to the pelvis (5040 cGy) and 2 applications of HDR-ISBT to a dose of 3600 cGy to the implanted volume. Sixty-one percent of patients also received interstitial hyperthermia, and 94 (81%) patients received chemotherapy. Results: Clinical LRC was achieved in 99 (85.3%) patients. Three-year DFS rates were 59%, 67%, 71%, and 57% for patients with stage IB, II, III, and IVA disease, respectively. The 5-year DFS and overall survival rates for the entire group were 60% and 44%, respectively. Acute and late toxicities were within acceptable limits. Conclusions: Locally advanced cervical cancer patients for whom intracavitary BT is unsuitable can achieve excellent LRC and OS with a combination of EBRT and HDR-ISBT.

  1. Interstitially stabilized phases in the zirconium-nickel system

    SciTech Connect (OSTI)

    MacKay, R.A.

    1993-07-01

    Addition of nonmetal interstitial atoms to Zr-Ni compounds has resulted in several new phases. A single-crystal x-ray study was carried out for Zr{sub 3}NiO. Zr{sub 4}Ni{sub 2}O is a high- temperature phase, forming in samples annealed at 1250 C. Huekel band calculations led to prediction and confirmation of additional phases in more electron rich systems. Other phases studied by XRD are Zr{sub 6}Ni{sub 4}Ti{sub 2}O{sub 0.6}, Nb{sub 6}Ni{sub 6}O, and Nb{sub 6}Ni{sub 4}Ta{sub 2}O{sub 2}. Phases identified by powder diffraction are Nb{sub 4}Ni{sub 2}O, Zr{sub 4}Cu{sub 2}O, and Zr{sub 6}Co{sub 4}Ti{sub 2}O. New Zr kappa phases in space group P6s{sub 3}/mmc were found: Zr{sub 9}Mo{sub 4}SO{sub x} and Zr{sub 9}W{sub 4}(S,Ni)O{sub 3}. A new structure type was discovered with Zr{sub 6}Ni{sub 6}TiSiO{sub 1.8}. In all these interstitially stabilized phases, O is coordinated in Zr octahedral; there are no Ni-O interactions.

  2. Intensity-Modulated Radiotherapy as Primary Therapy for Prostate Cancer: Report on Acute Toxicity After Dose Escalation With Simultaneous Integrated Boost to Intraprostatic Lesion

    SciTech Connect (OSTI)

    Fonteyne, Valerie Villeirs, Geert; Speleers, Bruno; Neve, Wilfried de; Wagter, Carlos de; Lumen, Nicolas; Meerleer, Gert de

    2008-11-01

    Purpose: To report on the acute toxicity of a third escalation level using intensity-modulated radiotherapy for prostate cancer (PCa) and the acute toxicity resulting from delivery of a simultaneous integrated boost (SIB) to an intraprostatic lesion (IPL) detected on magnetic resonance imaging (MRI), with or without spectroscopy. Methods and Materials: Between January 2002 and March 2007, we treated 230 patients with intensity-modulated radiotherapy to a third escalation level as primary therapy for prostate cancer. If an IPL (defined by MRI or MRI plus spectroscopy) was present, a SIB was delivered to the IPL. To report on acute toxicity, patients were seen weekly during treatment and 1 and 3 months after treatment. Toxicity was scored using the Radiation Therapy Oncology Group toxicity scale, supplemented by an in-house-developed scoring system. Results: The median dose to the planning target volume was 78 Gy. An IPL was found in 118 patients. The median dose to the MRI-detected IPL and MRI plus spectroscopy-detected IPL was 81 Gy and 82 Gy, respectively. No Grade 3 or 4 acute gastrointestinal toxicity developed. Grade 2 acute gastrointestinal toxicity was present in 26 patients (11%). Grade 3 genitourinary toxicity was present in 15 patients (7%), and 95 patients developed Grade 2 acute genitourinary toxicity (41%). No statistically significant increase was found in Grade 2-3 acute gastrointestinal or genitourinary toxicity after a SIB to an IPL. Conclusion: The results of our study have shown that treatment-induced acute toxicity remains low when intensity-modulated radiotherapy to 80 Gy as primary therapy for prostate cancer is used. In addition, a SIB to an IPL did not increase the severity or incidence of acute toxicity.

  3. Measurements of the oxidation state and concentration of plutonium in interstitial waters of the Irish Sea

    SciTech Connect (OSTI)

    Nelson, D.M.; Lovett, M.B.

    1980-01-01

    The question of plutonium movement in interstitial waters resulting from diffusion along concentration gradients or from advective flow is addressed. The results of measurements of both the concentration and the oxidation state of plutonium in interstitial water collected from sediments near the Windscale discharge, in the solid phases of these sediments and in seawater and suspended solids collected at the coring locations are discussed. (ACR)

  4. Is Stereotactic Body Radiation Therapy an Attractive Option for Unresectable Liver Metastases? A Preliminary Report From a Phase 2 Trial

    SciTech Connect (OSTI)

    Scorsetti, Marta; Arcangeli, Stefano; Tozzi, Angelo; Comito, Tiziana; Alongi, Filippo; Navarria, Pierina; Mancosu, Pietro; Reggiori, Giacomo; Fogliata, Antonella; Torzilli, Guido; Tomatis, Stefano; Cozzi, Luca

    2013-06-01

    Purpose: To evaluate the feasibility of high-dose stereotactic body radiation therapy (SBRT) in the treatment of unresectable liver metastases. Methods and Materials: Patients with 1 to 3 liver metastases, with maximum individual tumor diameters less than 6 cm and a Karnofsky Performance Status of at least 70, were enrolled and treated by SBRT on a phase 2 clinical trial. Dose prescription was 75 Gy on 3 consecutive days. SBRT was delivered using the volumetric modulated arc therapy by RapidArc (Varian, Palo Alto, CA) technique. The primary end-point was in-field local control. Secondary end-points were toxicity and survival. Results: Between February 2010 and September 2011, a total of 61 patients with 76 lesions were treated. Among the patients, 21 (34.3%) had stable extrahepatic disease at study entry. The most frequent primary sites were colorectal (45.9%) and breast (18%). Of the patients, 78.7% had 1 lesion, 18.0% had 2 lesions, and 3.3% had 3 lesions. After a median of 12 months (range, 2-26 months), the in-field local response rate was 94%. The median overall survival rate was 19 months, and actuarial survival at 12 months was 83.5%. None of the patients experienced grade 3 or higher acute toxicity. No radiation-induced liver disease was detected. One patient experienced G3 late toxicity at 6 months, resulting from chest wall pain. Conclusions: SBRT for unresectable liver metastases can be considered an effective, safe, and noninvasive therapeutic option, with excellent rates of local control and a low treatment-related toxicity.

  5. Muddy Water? Variation in Reporting Receipt of Breast Cancer Radiation Therapy by Population-Based Tumor Registries

    SciTech Connect (OSTI)

    Walker, Gary V.; Giordano, Sharon H.; Williams, Melanie; Jiang, Jing; Niu, Jiangong; MacKinnon, Jill; Anderson, Patricia; Wohler, Brad; Sinclair, Amber H.; Boscoe, Francis P.; Schymura, Maria J.; Buchholz, Thomas A.; Smith, Benjamin D.

    2013-07-15

    Purpose: To evaluate, in the setting of breast cancer, the accuracy of registry radiation therapy (RT) coding compared with the gold standard of Medicare claims. Methods and Materials: Using Surveillance, Epidemiology, and End Results (SEER)–Medicare data, we identified 73,077 patients aged ≥66 years diagnosed with breast cancer in the period 2001-2007. Underascertainment (1 - sensitivity), sensitivity, specificity, κ, and χ{sup 2} were calculated for RT receipt determined by registry data versus claims. Multivariate logistic regression characterized patient, treatment, and geographic factors associated with underascertainment of RT. Findings in the SEER–Medicare registries were compared with three non-SEER registries (Florida, New York, and Texas). Results: In the SEER–Medicare registries, 41.6% (n=30,386) of patients received RT according to registry coding, versus 49.3% (n=36,047) according to Medicare claims (P<.001). Underascertainment of RT was more likely if patients resided in a newer SEER registry (odds ratio [OR] 1.70, 95% confidence interval [CI] 1.60-1.80; P<.001), rural county (OR 1.34, 95% CI 1.21-1.48; P<.001), or if RT was delayed (OR 1.006/day, 95% CI 1.006-1.007; P<.001). Underascertainment of RT receipt in SEER registries was 18.7% (95% CI 18.6-18.8%), compared with 44.3% (95% CI 44.0-44.5%) in non-SEER registries. Conclusions: Population-based tumor registries are highly variable in ascertainment of RT receipt and should be augmented with other data sources when evaluating quality of breast cancer care. Future work should identify opportunities for the radiation oncology community to partner with registries to improve accuracy of treatment data.

  6. Quality assurance for image-guided radiation therapy utilizing CT-based technologies: A report of the AAPM TG-179

    SciTech Connect (OSTI)

    Bissonnette, Jean-Pierre; Balter, Peter A.; Dong Lei; Langen, Katja M.; Lovelock, D. Michael; Miften, Moyed; Moseley, Douglas J.; Pouliot, Jean; Sonke, Jan-Jakob; Yoo, Sua

    2012-04-15

    Purpose: Commercial CT-based image-guided radiotherapy (IGRT) systems allow widespread management of geometric variations in patient setup and internal organ motion. This document provides consensus recommendations for quality assurance protocols that ensure patient safety and patient treatment fidelity for such systems. Methods: The AAPM TG-179 reviews clinical implementation and quality assurance aspects for commercially available CT-based IGRT, each with their unique capabilities and underlying physics. The systems described are kilovolt and megavolt cone-beam CT, fan-beam MVCT, and CT-on-rails. A summary of the literature describing current clinical usage is also provided. Results: This report proposes a generic quality assurance program for CT-based IGRT systems in an effort to provide a vendor-independent program for clinical users. Published data from long-term, repeated quality control tests form the basis of the proposed test frequencies and tolerances.Conclusion: A program for quality control of CT-based image-guidance systems has been produced, with focus on geometry, image quality, image dose, system operation, and safety. Agreement and clarification with respect to reports from the AAPM TG-101, TG-104, TG-142, and TG-148 has been addressed.

  7. Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reports Reports Individual Permit reports are prepared annually to facilitate public review of activities for the previous year. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email Individual Permit for Storm Water Reports Annual Report 2015 (pdf) 2014 (pdf) 2013 (pdf) Submittal Letter (pdf) 2012 (pdf) Submittal Letter (pdf) 2011 (pdf) Background Metals and Radioactivity Report Background Metals Concentrations and

  8. Ultra-low contact resistance at an epitaxial metal/oxide heterojunction through interstitial site doping

    SciTech Connect (OSTI)

    Chambers, Scott A.; Gu, Meng; Sushko, Petr V.; Yang, Hao; Wang, Chong M.; Browning, Nigel D.

    2013-08-07

    The ability to form reliable, low-resistance Ohmic contacts is of critical importance to the ongoing development of oxide electronics. Most metals form Schottky barriers when deposited on oxide surfaces. Ohmic contacts rarely occur, and the associated contact resistances are not particularly low. Little is known at an atomistic level about what leads to a good Ohmic contact on a wide-gap oxide. Here we describe the structure of a simple, yet exceptionally low-contact resistance Ohmic metal on an important oxide semiconductor -- epitaxial Cr on Nb-doped SrTiO3(001). Heteroepitaxial growth is accompanied by Cr diffusion into the STO and occupation of interstitial sites within the first few atomic planes. Interstitial Cr is ionized and the resulting electrons occupy the STO conduction band, resulting in effective metallization near the interface.

  9. Chemical composition of interstitial waters from the Japan Sea, ODP Leg 128

    SciTech Connect (OSTI)

    Sturz, A. ); Von Breymann, M.; Dunbar, R. )

    1990-06-01

    During ODP Leg 128, interstitial waters were recovered from Oki Ridge (Site 798) and Kita-Yamato Trough (Site 799) sediment, Sea of Japan. Interstitial water chemical composition reflects diagenetic processes. Evidence indicating organic matter degradation processes includes sulfate depletion, high ammonium concentrations, and shallow maxima of dissolved phosphate. Rapid alkalinity increases in the uppermost sections of the sediments are accompanied by decreases in dissolved calcium, reflecting inorganic calcite precipitation. Authigenic dolomitization results in changes in slopes of the Mg/Ca molar ratios with depth. The opal-A/opal-CT transition is documented by the concentration depth profiles of dissolved silica and lithium. Dolomitization precedes the opal-A/opal-CT transition at both sites. Kita-Yamato Trough sediments show an abrupt change in the compositional character of the pore fluids below 435 mbsf, which coincides with the occurrence of low porosity and high bulk density layers composed of dolomite and opal-CT. These layers impede to some extent diffusional communication with the overlying interstitial waters. The interstitial waters in sediments below 435 mbsf have chloride concentrations of 504-515 mM, significantly lower than that of modern day Japan Sea water (540 mM). The presence of low chloride waters within Miocene age sediments may indicate: (1) diagenetic reactions that involve the release of exchangeable and structural bound water from clay minerals and/or opal-A, (2) Miocene connate brackish lake water, (3) phase separation of hydrothermal fluids associated with rifting, (4) potential effects of clay membrane filtration in a high pressure zone.

  10. Strength and formability of ultra-low-carbon Ti-IF steels[Interstitial Free

    SciTech Connect (OSTI)

    Jeong, W.C.

    2000-04-01

    Ultra-low-carbon interstitial free (IF) steel sheets bearing Ti and/or Nb have been extensively used for automotive panels because of superior formability and nonaging properties. It is well known that the interstitial elements such as C and N play important roles in the formability. The lower the contents of the C and N in steel, the better the formability of the steel. The demands for the steel with excellent formability from automotive industry will accelerate the progress in the steelmaking process, leading to the development of the ultra-low-carbon steel. With the advent and installation of improved vacuum degassing equipment in the steelmaking process, it is now possible to consistently produce ultra-low-carbon content of 0.002 to 0.005 wt pct. It is expected that in the near future, the C and N contents can be lowered to as low as 0.001 pct or less. This study is focused on strength and formability in the extremely ultra-low-carbon IF steels containing about 0.001 pct carbon.

  11. REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOE/NV/11718-387 ECOLOGICAL MONITORING AND COMPLIANCE PROGRAM FISCAL YEAR 1999 REPORT December 1999 Prepared by Ecological Services P.O. Box 98521 Las Vegas, NV 89193-8521 DISCLAIMER STATEMENT Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U.S. Government or any agency thereof or its contractors or subcontractors.

  12. Correlation between the electronic structures and diffusion paths of interstitial defects in semiconductors: The case in CdTe

    SciTech Connect (OSTI)

    Ma, Jie; Yang, Jihui; Da Silva, J. L.F.; Wei, Su-Huai

    2014-10-30

    Using first-principles calculations, we study the diffusions of interstitial defects Cd, Cu, Te, and Cl in CdTe. We find that the diffusion behavior is strongly correlated with the electronic structure of the interstitial diffuser. For Cd and Cu, because the defect state is the non-degenerated slike state under Td symmetry, the diffusions are almost along the [111] directions between the tetrahedral sites, although the diffusion of Cu shows some deviation due to the s - d coupling. The diffusions of the neutral and charged Cd and Cu follow similar paths. However, for Te and Cl atoms, because the defect state is the degenerated p-like state under Td symmetry, large distortions occur. Therefore, the diffusion paths are very different from those of Cd and Cu interstitials, and depend strongly on the charge states of the interstitial atoms. For Te, we find that the distortion is mostly stabilized by the crystal-field splitting, but for Cl, the exchange splitting plays a more important role.

  13. Correlation between the electronic structures and diffusion paths of interstitial defects in semiconductors: The case in CdTe

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ma, Jie; Yang, Jihui; Da Silva, J. L.F.; Wei, Su-Huai

    2014-10-30

    Using first-principles calculations, we study the diffusions of interstitial defects Cd, Cu, Te, and Cl in CdTe. We find that the diffusion behavior is strongly correlated with the electronic structure of the interstitial diffuser. For Cd and Cu, because the defect state is the non-degenerated slike state under Td symmetry, the diffusions are almost along the [111] directions between the tetrahedral sites, although the diffusion of Cu shows some deviation due to the s - d coupling. The diffusions of the neutral and charged Cd and Cu follow similar paths. However, for Te and Cl atoms, because the defect statemore » is the degenerated p-like state under Td symmetry, large distortions occur. Therefore, the diffusion paths are very different from those of Cd and Cu interstitials, and depend strongly on the charge states of the interstitial atoms. For Te, we find that the distortion is mostly stabilized by the crystal-field splitting, but for Cl, the exchange splitting plays a more important role.« less

  14. Quality Assurance of Multifractionated Pelvic Interstitial Brachytherapy for Postoperative Recurrences of Cervical Cancers: A Prospective Study

    SciTech Connect (OSTI)

    Shukla, Pragya; Chopra, Supriya; Engineer, Reena; Mahantshetty, Umesh; Paul, Siji Nojin; Phurailatpam, Reena; SV, Jamema; Shrivastava, Shyam K.

    2012-03-15

    Purpose: To evaluate three-dimensional needle displacements during multifractionated interstitial brachytherapy (BT) for cervical cancers. Methods and Materials: Patients scheduled to undergo pelvic interstitial BT for postoperative and or postradiation vault recurrences were included from November 2009 to December 2010. All procedures were performed under spinal anesthesia. Postprocedure BT planning CT scans were obtained with patients in supine position with arms on the chest (interslice thickness of 3 mm). Thereafter, verification CT was repeated at every alternate fraction. Needle displacements were measured in reference to a relocatable bony point. The mean cranial, caudal, anteroposterior, and mediolateral displacements were recorded. Statistical significance of mean interfraction displacements was evaluated with Wilcoxon Test. Results: Twenty patients were included. Seventeen received boost BT (20 Gy/5 fractions/3 days) after external radiation, three received radical BT alone (36 Gy/9 fractions/5-8 days). An average of three scans (range, 2-3) were available per patient, and 357 needle displacements were analyzed. For the entire study cohort, the average of mean needle displacement was 2.5 mm (range, 0-7.4), 17.4 mm (range, 0-27.9), 1.7 mm (range, 0-6.7), 2.1 mm (range, 0-9.5), 1.7 mm (range, 0-9.3), and 0.6 mm (range, 0-7.8) in cranial, caudal, anterior, posterior, right, and left directions, respectively. The mean displacement in the caudal direction was higher between Days 1 and 2 than that between Days 2 and 3 (13.4 mm vs. 3.8 mm; p = 0.01). The average caudal displacements were no different between reirradiation and boost cohort (15.2 vs. 17.8 mm). Conclusions: Clinically significant caudal displacements occur during multifractionated pelvic brachytherapy. Optimal margins need to be incorporated while preplanning brachytherapy to account for interfraction displacements.

  15. Modeling Local Control After Hypofractionated Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer: A Report From the Elekta Collaborative Lung Research Group

    SciTech Connect (OSTI)

    Ohri, Nitin; Werner-Wasik, Maria; Grills, Inga S.; Belderbos, Jose; Hope, Andrew; Yan Di; Kestin, Larry L.; Guckenberger, Matthias; Sonke, Jan-Jakob; Bissonnette, Jean-Pierre; Xiao, Ying

    2012-11-01

    Purpose: Hypofractionated stereotactic body radiation therapy (SBRT) has emerged as an effective treatment option for early-stage non-small cell lung cancer (NSCLC). Using data collected by the Elekta Lung Research Group, we generated a tumor control probability (TCP) model that predicts 2-year local control after SBRT as a function of biologically effective dose (BED) and tumor size. Methods and Materials: We formulated our TCP model as follows: TCP = e{sup [BED10-c Asterisk-Operator L-TCD50]/k} Division-Sign (1 + e{sup [BED10-c Asterisk-Operator L-TCD50]/k}), where BED10 is the biologically effective SBRT dose, c is a constant, L is the maximal tumor diameter, and TCD50 and k are parameters that define the shape of the TCP curve. Least-squares optimization with a bootstrap resampling approach was used to identify the values of c, TCD50, and k that provided the best fit with observed actuarial 2-year local control rates. Results: Data from 504 NSCLC tumors treated with a variety of SBRT schedules were available. The mean follow-up time was 18.4 months, and 26 local recurrences were observed. The optimal values for c, TCD50, and k were 10 Gy/cm, 0 Gy, and 31 Gy, respectively. Thus, size-adjusted BED (sBED) may be defined as BED minus 10 times the tumor diameter (in centimeters). Our TCP model indicates that sBED values of 44 Gy, 69 Gy, and 93 Gy provide 80%, 90%, and 95% chances of tumor control at 2 years, respectively. When patients were grouped by sBED, the model accurately characterized the relationship between sBED and actuarial 2-year local control (r=0.847, P=.008). Conclusion: We have developed a TCP model that predicts 2-year local control rate after hypofractionated SBRT for early-stage NSCLC as a function of biologically effective dose and tumor diameter. Further testing of this model with additional datasets is warranted.

  16. Mixed ligand chelate therapy for plutonium and toxic metals from energy power production. Final report, April 15, 1977-October 14, 1980. [Mice

    SciTech Connect (OSTI)

    Schubert, J.

    1980-10-14

    The results of experiments are summarized on the ability of combinations of chelating agents to modify the genotoxicity or tissue distributions. The mutagenicities of Cr and of chelating agents were determined. The metals described in the report are Pu(IV), Cd(II), Cr(III), and Cr(VI). Accurate measurements were made of the ability of CaNa/sub 2/EDTA, CaNa/sub 3/DTPA, and DMPS to reduce mortality in mice given doses (i.p.) of CdCl/sub 2/ well above the 100% lethal level. The efficacy in terms of the mmoles/kg needed to reduce the mortality was: DTPA > EDTA > DMPS. The combination of DTPA + DMPS proved most promising though little evidence for mixed complex formation was noted. Potentiometric titration studies the case of Pu(IV) a few combinations proved effective, but only when given shortly after Pu administration and then only in the liver but not the skeleton. It is recommended that metabolically stable chelating agents be used in combinations, especially for those combinations which may form very stable mixed ligand chelates.

  17. Phase 3 Trial of Domiciliary Humidification to Mitigate Acute Mucosal Toxicity During Radiation Therapy for Head-and-Neck Cancer: First Report of Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM Study

    SciTech Connect (OSTI)

    Macann, Andrew; Fua, Tsien; Milross, Chris G.; Porceddu, Sandro V.; Penniment, Michael; Wratten, Chris; Krawitz, Hedley; Poulsen, Michael; Tang, Colin I.; Morton, Randall P.; Hay, K. David; Thomson, Vicki; Bell, Melanie L.; King, Madeleine T.; Fraser-Browne, Carol L.; Hockey, Hans-Ulrich P.

    2014-03-01

    Purpose: To assess the impact of domicile-based humidification on symptom burden during radiation therapy (RT) for head-and-neck (H and N) cancer. Methods and Materials: From June 2007 through June 2011, 210 patients with H and N cancer receiving RT were randomized to either a control arm or to receive humidification using the Fisher and Paykel Healthcare MR880 humidifier. Humidification commenced on day 1 of RT and continued until Common Terminology Criteria for Adverse Events (CTCAE), version 3.0, clinical mucositis (CMuc) grade ≤1 occurred. Forty-three patients (42%) met a defined benchmark for humidification compliance and contributed to per protocol (PP) analysis. Acute toxicities, hospitalizations, and feeding tube events were recorded prospectively. The McMaster University Head and Neck Radiotherapy Questionnaire (HNRQ) was used for patient-reported outcomes. The primary endpoint was area under the curve (AUC) for CMuc grade ≥2. Results: There were no significant differences in AUC for CMuc ≥2 between the 2 arms. Humidification patients had significantly fewer days in hospital (P=.017). In compliant PP patients, the AUC for CTCAE functional mucositis score (FMuc) ≥2 was significantly reduced (P=.009), and the proportion who never required a feeding tube was significantly greater (P=.04). HNRQ PP analysis estimates also in the direction favoring humidification with less symptom severity, although differences at most time points did not reach significance. Conclusions: TROG 07.03 has provided efficacy signals consistent with a role for humidification in reducing symptom burden from mucositis, but the influence of humidification compliance on the results moderates recommendations regarding its practical utility.

  18. Comparison of precipitate behaviors in ultra-low carbon, titanium-stabilized interstitial free steel sheets under different annealing processes

    SciTech Connect (OSTI)

    Shi, J.; Wang, X.

    1999-12-01

    Ultra-low carbon, titanium-stabilized interstitial free (ULC Ti-IF) steel sheets are widely used in the automobile industry because of excellent deep drawability. The annealing process is critical to their final property, and there are two different annealing processes used in industrial production of interstitial free (IF) steel sheets, namely batch annealing and continuous annealing. In this study, precipitation behaviors of titanium IF steels, that is, TiN, TiS, Ti{sub 4}(CS){sub 2}, and TiC, the size and dispersion of TiN, TiS, and Ti{sub 4}(CS){sub 2} remained almost unchanged after either annealing process. Conversely, the average size of a TiC particle increased substantially after both annealing processes, while TiC after continuous annealing was larger than that after batch annealing due to the higher heating temperature of continuous annealing. Two new particles, FeTiP and (Ti, Mn)S, were also observed in the batch annealing process but not in continuous annealing. The structure of FeTiP and (Ti, Mn)S were studied, and furthermore the evolution of FeTiP precipitation was found to be closely related to recrystallization in batch annealing. Finally, the interrelation among processing parameters, precipitation behaviors, and final property was studied.

  19. Accelerators for Cancer Therapy

    DOE R&D Accomplishments [OSTI]

    Lennox, Arlene J.

    2000-05-30

    The vast majority of radiation treatments for cancerous tumors are given using electron linacs that provide both electrons and photons at several energies. Design and construction of these linacs are based on mature technology that is rapidly becoming more and more standardized and sophisticated. The use of hadrons such as neutrons, protons, alphas, or carbon, oxygen and neon ions is relatively new. Accelerators for hadron therapy are far from standardized, but the use of hadron therapy as an alternative to conventional radiation has led to significant improvements and refinements in conventional treatment techniques. This paper presents the rationale for radiation therapy, describes the accelerators used in conventional and hadron therapy, and outlines the issues that must still be resolved in the emerging field of hadron therapy.

  20. Structure, Stoichiometry and Stability in Magnetoplumbite and {beta}-Alumina Structured Type Ceramics. Final Report

    SciTech Connect (OSTI)

    Cormack, A. N.

    2004-03-01

    Work has been completed on the atomistic simulation of hexa-aluminate ceramics with the magnetoplumbite and beta-alumina type structures. In this report, three aspects of the work are highlighted. One is the simulation of surface structures. The second concerns details of the interstitially mechanisms observed in molecular dynamics simulations. The novel result here is the observation that the lattice ion always leaves its Beevers-Ross site before the aBR interstitial begins to move towards the lattice site. It is also found that, as expected, the interstitial mechanism is the most common mechanism in the heavily disordered nonstoichiometric structure, as well as in the stoichiometric material. Finally, the disposition of trivalent europium in the phosphor material BAM has been elucidated.

  1. Simulation of xenon, uranium vacancy and interstitial diffusion and grain boundary segregation in UO2

    SciTech Connect (OSTI)

    Andersson, Anders D.; Tonks, Michael R.; Casillas, Luis; Nerikar, Pankaj; Vyas, Shyam; Uberuaga, Blas P.; Stanek, Christopher R.

    2014-10-31

    In light water reactor fuel, gaseous fission products segregate to grain boundaries, resulting in the nucleation and growth of large intergranular fission gas bubbles. Based on the mechanisms established from density functional theory (DFT) and empirical potential calculations 1, continuum models for diffusion of xenon (Xe), uranium (U) vacancies and U interstitials in UO2 have been derived for both intrinsic conditions and under irradiation. Segregation of Xe to grain boundaries is described by combining the bulk diffusion model with a model for the interaction between Xe atoms and three different grain boundaries in UO2 ( ?5 tilt, ?5 twist and a high angle random boundary),as derived from atomistic calculations. All models are implemented in the MARMOT phase field code, which is used to calculate effective Xe and U diffusivities as well as redistribution for a few simple microstructures.

  2. In-Situ Characterization of Cloud Condensation Nuclei, Interstitial, and background Particles using Single Particle Mass Spectrometer, SPLAT II

    SciTech Connect (OSTI)

    Zelenyuk, Alla; Imre, D.; Earle, Michael; Easter, Richard C.; Korolev, Alexei; Leaitch, W. R.; Liu, Peter; Macdonald, A. M.; Ovchinnikov, Mikhail; Strapp, Walter

    2010-10-01

    Aerosol indirect effect remains the most uncertain aspect of climate change modeling because proper test requires knowledge of individual particles sizes and compositions with high spatial and temporal resolution. We present the first deployment of a single particle mass spectrometer (SPLAT II) that is operated in a dual data acquisition mode to measure all the required individual particle properties with sufficient temporal resolution to definitively resolve the aerosol-cloud interaction in this exemplary case. We measured particle number concentrations, asphericity, and individual particle size, composition, and density with better than 60 seconds resolution. SPLAT II measured particle number concentrations between 70 particles cm-3and 300 particles cm-3, an average particle density of 1.4 g cm-3. Found that most particles are composed of oxygenated organics, many of which are mixed with sulfates. Biomass burn particles some with sulfates were prevalent, particularly at higher altitudes, and processed sea-salt was observed over the ocean. Analysis of cloud residuals shows that with time cloud droplets acquire sulfate by the reaction of peroxide with SO2. Based on the particle mass spectra and densities we find that the compositions of cloud condensation nuclei are similar to those of background aerosol but, contain on average ~7% more sulfate, and do not include dust and metallic particles. A comparison between the size distributions of background, activated, and interstitial particles shows that while nearly none of the activated particles is smaller than 115 nm, more than 80% of interstitial particles are smaller than 115 nm. We conclude that for this cloud the most important difference between CCN and background aerosol is particle size although having more sulfate also helps.

  3. Neutron capture therapies

    DOE Patents [OSTI]

    Yanch, Jacquelyn C.; Shefer, Ruth E.; Klinkowstein, Robert E.

    1999-01-01

    In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.

  4. WE-G-17A-05: Real-Time Catheter Localization Using An Active MR Tracker for Interstitial Brachytherapy

    SciTech Connect (OSTI)

    Wang, W; Damato, A; Viswanathan, A; Cormack, R; Penzkofer, T; Schmidt, E; Pan, L; Gilson, W; Seethamraju, R

    2014-06-15

    Purpose: To develop a novel active MR-tracking system which can provide accurate and rapid localization of brachytherapy catheters, and assess its reliability and spatial accuracy in comparison to standard catheter digitization using MR images. Methods: An active MR tracker for brachytherapy was constructed by adding three printed-circuit micro-coils to the shaft of a commercial metallic stylet. A gel phantom with an embedded framework was built, into which fifteen 14-Gauge catheters were placed, following either with parallel or crossed paths. The tracker was inserted sequentially into each catheter, with MR-tracking running continuously. Tracking was also performed during the tracker's removal from each catheter. Catheter trajectories measured from the insertion and the removal procedures using the same micro-coil were compared, as well as trajectories obtained using different micro-coils. A 3D high-resolution MR image dataset of the phantom was acquired and imported into a treatment planning system (TPS) for catheter digitization. A comparison between MR-tracked positions and positions digitized from MR images by TPS was performed. Results: The MR tracking shows good consistency for varying catheter paths and for all micro-coils (mean difference ∼1.1 mm). The average distance between the MR-tracking trajectory and catheter digitization from the MR images was 1.1 mm. Ambiguity in catheter assignment from images due to crossed paths was resolved by active tracking. When tracking was interleaved with imaging, real-time images were continuously acquired at the instantaneous tip positions and displayed on an external workstation. Conclusion: The active MR tracker may be used to provide an independent measurement of catheter location in the MR environment, potentially eliminating the need for subsequent CT. It may also be used to control realtime imaging of catheter placement. This will enable MR-based brachytherapy planning of interstitial implants without ionizing radiation, with the potential to enable dosimetric guidance of catheter placement. We gratefully acknowledge support from the American Heart Association SDG 10SDG2610139, NIH 1R21CA158987-01A1, U41-RR019703, and R21 CA 167800, as well as a BWH Department of Radiation Oncology post-doctoral fellowship support. Li Pan and Wesley Gilson are employees of Siemens Corporation, Corporate Technology. Ravi Seethamraju is an employee of Siemens Healthcare.

  5. Once-Daily Radiation Therapy for Inflammatory Breast Cancer

    SciTech Connect (OSTI)

    Brown, Lindsay; Harmsen, William; Blanchard, Miran; Goetz, Matthew; Jakub, James; Mutter, Robert; Petersen, Ivy; Rooney, Jessica; Stauder, Michael; Yan, Elizabeth; Laack, Nadia

    2014-08-01

    Purpose: Inflammatory breast cancer (IBC) is a rare and aggressive breast cancer variant treated with multimodality therapy. A variety of approaches intended to escalate the intensity and efficacy of radiation therapy have been reported, including twice-daily radiation therapy, dose escalation, and aggressive use of bolus. Herein, we examine our outcomes for patients treated with once-daily radiation therapy with aggressive bolus utilization, focusing on treatment technique. Methods and Materials: A retrospective review of patients with nonmetastatic IBC treated from January 1, 2000, through December 31, 2010, was performed. Locoregional control (LRC), disease-free survival (DFS), overall survival (OS) and predictors thereof were assessed. Results: Fifty-two women with IBC were identified, 49 (94%) of whom were treated with neoadjuvant chemotherapy. All underwent mastectomy followed by adjuvant radiation therapy. Radiation was delivered in once-daily fractions of 1.8 to 2.25 Gy (median, 2 Gy). Patients were typically treated with daily 1-cm bolus throughout treatment, and 33 (63%) received a subsequent boost to the mastectomy scar. Five-year Kaplan Meier survival estimates for LRC, DFS, and OS were 81%, 56%, and 64%, respectively. Locoregional recurrence was associated with poorer OS (P<.001; hazard ratio [HR], 4.1). Extracapsular extension was associated with worse LRC (P=.02), DFS (P=.007), and OS (P=.002). Age greater than 50 years was associated with better DFS (P=.03). Pathologic complete response was associated with a trend toward improved LRC (P=.06). Conclusions: Once-daily radiation therapy with aggressive use of bolus for IBC results in outcomes consistent with previous reports using various intensified radiation therapy regimens. LRC remains a challenge despite modern systemic therapy. Extracapsular extension, age ≤50 years, and lack of complete response to chemotherapy appear to be associated with worse outcomes. Novel strategies are needed in IBC, particularly among these subsets of patients.

  6. Recombination radius of a Frenkel pair and capture radius of a self-interstitial atom by vacancy clusters in bcc Fe

    SciTech Connect (OSTI)

    Nakashima, Kenichi; Stoller, Roger E.; Xu, Haixuan

    2015-08-04

    The recombination radius of a Frenkel pair is a fundamental parameter for the object kinetic Monte Carlo (OKMC) and mean field rate theory (RT) methods that are used to investigate irradiation damage accumulation in neutron irradiated nuclear materials. The recombination radius in bcc Fe has been studied both experimentally and numerically, however there is no general consensus about its value. The detailed atomistic processes of recombination also remain uncertain. Values from 1:0a? to 3:3a? have been employed as a recombination radius in previous studies using OKMC and RT. The recombination process of a Frenkel pair is investigated at the atomic level using the self-evolved atomistic kinetic Monte Carlo (SEAKMC) method in this paper. SEAKMC calculations reveal that a self-interstitial atom recombines with a vacancy in a spontaneous reaction from several nearby sites following characteristic pathways. The recombination radius of a Frenkel pair is estimated to be 2.26a? by taking the average of the recombination distances from 80 simulation cases. This value agrees well with the experimental estimate. In addition, we apply these procedures to the capture radius of a self-interstitial atom by a vacancy cluster. The capture radius is found to gradually increase with the size of the vacancy cluster. The fitting curve for the capture radius is obtained as a function of the number of vacancies in the cluster.

  7. Recombination radius of a Frenkel pair and capture radius of a self-interstitial atom by vacancy clusters in bcc Fe

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Nakashima, Kenichi; Stoller, Roger E.; Xu, Haixuan

    2015-01-01

    The recombination radius of a Frenkel pair is a fundamental parameter for the object kinetic Monte Carlo (OKMC) and mean field rate theory (RT) methods that are used to investigate irradiation damage accumulation in neutron irradiated nuclear materials. The recombination radius in bcc Fe has been studied both experimentally and numerically, however there is no general consensus about its value. The detailed atomistic processes of recombination also remain uncertain. Values from 1:0a₀ to 3:3a₀ have been employed as a recombination radius in previous studies using OKMC and RT. The recombination process of a Frenkel pair is investigated at the atomicmore » level using the self-evolved atomistic kinetic Monte Carlo (SEAKMC) method in this paper. SEAKMC calculations reveal that a self-interstitial atom recombines with a vacancy in a spontaneous reaction from several nearby sites following characteristic pathways. The recombination radius of a Frenkel pair is estimated to be 2.26a₀ by taking the average of the recombination distances from 80 simulation cases. This value agrees well with the experimental estimate. In addition, we apply these procedures to the capture radius of a self-interstitial atom by a vacancy cluster. The capture radius is found to gradually increase with the size of the vacancy cluster. The fitting curve for the capture radius is obtained as a function of the number of vacancies in the cluster.« less

  8. A Prospective Longitudinal Clinical Trial Evaluating Quality of Life After Breast-Conserving Surgery and High-Dose-Rate Interstitial Brachytherapy for Early-Stage Breast Cancer

    SciTech Connect (OSTI)

    Garsa, Adam A.; Ferraro, Daniel J.; DeWees, Todd A.; Deshields, Teresa L.; Margenthaler, Julie A.; Cyr, Amy E.; Naughton, Michael; Aft, Rebecca; Gillanders, William E.; Eberlein, Timothy; Matesa, Melissa A.; Ochoa, Laura L.; Zoberi, Imran

    2013-12-01

    Purpose: To prospectively examine quality of life (QOL) of patients with early stage breast cancer treated with accelerated partial breast irradiation (APBI) using high-dose-rate (HDR) interstitial brachytherapy. Methods and Materials: Between March 2004 and December 2008, 151 patients with early stage breast cancer were enrolled in a phase 2 prospective clinical trial. Eligible patients included those with Tis-T2 tumors measuring ?3 cm excised with negative surgical margins and with no nodal involvement. Patients received 3.4 Gy twice daily to a total dose of 34 Gy. QOL was measured using European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, version 3.0, and QLQ-BR23 questionnaires. The QLQ-C30 and QLQ-BR23 questionnaires were evaluated during pretreatment and then at 6 to 8 weeks, 3 to 4 months, 6 to 8 months, and 1 and 2 years after treatment. Results: The median follow-up was 55 months. Breast symptom scores remained stable in the months after treatment, and they significantly improved 6 to 8 months after treatment. Scores for emotional functioning, social functioning, and future perspective showed significant improvement 2 years after treatment. Symptomatic fat necrosis was associated with several changes in QOL, including increased pain, breast symptoms, systemic treatment side effects, dyspnea, and fatigue, as well as decreased role functioning, emotional functioning, and social functioning. Conclusions: HDR multicatheter interstitial brachytherapy was well tolerated, with no significant detrimental effect on measured QOL scales/items through 2 years of follow-up. Compared to pretreatment scores, there was improvement in breast symptoms, emotional functioning, social functioning, and future perspective 2 years after treatment.

  9. Report to Congress on abnormal occurrences, October--December 1988

    SciTech Connect (OSTI)

    Not Available

    1989-04-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event which the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to Congress. This report covers the period from October 1 to December 31, 1988. For this reporting period, there were no abnormal occurrences at nuclear power plants licensed to operate. There was one abnormal occurrence under other NRC-issued licenses involving a medical therapy misadministration. Three other abnormal occurrences were reported by Agreement States. The State of New York reported an event involving multiple medical therapy misadministrations. The State of Maryland reported two events, both occurring at the same hospital. One involved a single medical therapy misadministration and the second involved multiple medical therapy misadministrations. The report also contains information updating some previously reported abnormal occurrences. 3 refs.

  10. Electrical signature analysis to quantify human and animal performance on fitness and therapy equipment such as a treadmill

    DOE Patents [OSTI]

    Cox, Daryl F.; Hochanadel, Charles D.; Haynes, Howard D.

    2010-05-18

    The invention is a human and animal performance data acquisition, analysis, and diagnostic system for fitness and therapy devices having an interface box removably disposed on incoming power wiring to a fitness and therapy device, at least one current transducer removably disposed on said interface box for sensing current signals to said fitness and therapy device, and a means for analyzing, displaying, and reporting said current signals to determine human and animal performance on said device using measurable parameters.

  11. Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy

    SciTech Connect (OSTI)

    Munaweera, Imalka; Balkus, Kenneth J. Jr. E-mail: Anthony.DiPasqua@unthsc.edu; Koneru, Bhuvaneswari; Shi, Yi; Di Pasqua, Anthony J. E-mail: Anthony.DiPasqua@unthsc.edu

    2014-11-01

    Over the last decade, the development and application of nanotechnology in cancer detection, diagnosis, and therapy have been widely reported. Engineering of vehicles for the simultaneous delivery of chemo- and radiotherapeutics increases the effectiveness of the therapy and reduces the dosage of each individual drug required to produce an observable therapeutic response. We here developed a novel chemoradiotherapeutic 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid coated/uncoated platinum drug loaded, holmium-containing, wrinkled mesoporous silica nanoparticle. The materials were characterized with TEM, FTIR, {sup 1}H NMR, energy dispersive x-ray, inductively coupled plasma-mass spectrometry, and zeta potential measurements. In vitro platinum drug release from both lipid coated and uncoated chemoradiotherapeutic wrinkled mesoporous silica are reported. Various kinetic models were used to analyze the release kinetics. The radioactivity of the chemoradiotherapeutic nanocarriers was measured after neutron-activation.

  12. Applicator-guided volumetric-modulated arc therapy for low-risk endometrial

    Office of Scientific and Technical Information (OSTI)

    cancer (Journal Article) | SciTech Connect Applicator-guided volumetric-modulated arc therapy for low-risk endometrial cancer Citation Details In-Document Search Title: Applicator-guided volumetric-modulated arc therapy for low-risk endometrial cancer The aim of this study was to report the feasibility of volumetric-modulated arc therapy (VMAT) in the postoperative irradiation of the vaginal vault. Moreover, the VMAT technique was compared with 3D conformal radiotherapy (3D-CRT) and

  13. Compact accelerator for medical therapy

    DOE Patents [OSTI]

    Caporaso, George J.; Chen, Yu-Jiuan; Hawkins, Steven A.; Sampayan, Stephen E.; Paul, Arthur C.

    2010-05-04

    A compact accelerator system having an integrated particle generator-linear accelerator with a compact, small-scale construction capable of producing an energetic (.about.70-250 MeV) proton beam or other nuclei and transporting the beam direction to a medical therapy patient without the need for bending magnets or other hardware often required for remote beam transport. The integrated particle generator-accelerator is actuable as a unitary body on a support structure to enable scanning of a particle beam by direction actuation of the particle generator-accelerator.

  14. Proton beam therapy control system

    DOE Patents [OSTI]

    Baumann, Michael A.; Beloussov, Alexandre V.; Bakir, Julide; Armon, Deganit; Olsen, Howard B.; Salem, Dana

    2010-09-21

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  15. Proton beam therapy control system

    DOE Patents [OSTI]

    Baumann, Michael A.; Beloussov, Alexandre V.; Bakir, Julide; Armon, Deganit; Olsen, Howard B.; Salem, Dana

    2008-07-08

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  16. Proton beam therapy control system

    DOE Patents [OSTI]

    Baumann, Michael A; Beloussov, Alexandre V; Bakir, Julide; Armon, Deganit; Olsen, Howard B; Salem, Dana

    2013-12-03

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  17. Proton beam therapy control system

    DOE Patents [OSTI]

    Baumann, Michael A; Beloussov, Alexandre V; Bakir, Julide; Armon, Deganit; Olsen, Howard B; Salem, Dana

    2013-06-25

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  18. Annual Reports - SRSCRO

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reports Annual Reports Annual Report 2015 Annual Report 2014 Annual Report 2013 Annual Report 2012 Annual Report 2011 Annual Report 2010 Annual Report 2009 Annual Report 2008...

  19. Workshop on neutron capture therapy

    SciTech Connect (OSTI)

    Fairchild, R.G.; Bond, V.P.

    1986-01-01

    Potentially optimal conditions for Neutron Capture Therapy (NCT) may soon be in hand due to the anticipated development of band-pass filtered beams relatively free of fast neutron contaminations, and of broadly applicable biomolecules for boron transport such as porphyrins and monoclonal antibodies. Consequently, a number of groups in the US are now devoting their efforts to exploring NCT for clinical application. The purpose of this Workshop was to bring these groups together to exchange views on significant problems of mutual interest, and to assure a unified and effective approach to the solutions. Several areas of preclinical investigation were deemed to be necessary before it would be possible to initiate clinical studies. As neither the monomer nor the dimer of sulfhydryl boron hydride is unequivocally preferable at this time, studies on both compounds should be continued until one is proven superior.

  20. Method for microbeam radiation therapy

    DOE Patents [OSTI]

    Slatkin, Daniel N. (Sound Beach, NY); Dilmanian, F. Avraham (Yaphank, NY); Spanne, Per O. (Shoreham, NY)

    1994-01-01

    A method of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation, in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue.

  1. Method for microbeam radiation therapy

    DOE Patents [OSTI]

    Slatkin, D.N.; Dilmanian, F.A.; Spanne, P.O.

    1994-08-16

    A method is disclosed of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation. The dose is in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue. No Drawings

  2. Find Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reports Find Reports Most of the reports sources below are publicly accessible. Question? 667-5809 Email Unclassified Los Alamos Reports Library Catalog - Print and electronic (1943-present) Los Alamos Authors (LANL-only access) - LA-, LA-CP, and LA-UR reports (1973-present) Los Alamos Research Online - Find published versions of Los Alamos research (2006-present) Classified reports - contact the SI-RMS Technical Report Collection for an appointment: phone icon 5-4168 / email icon

  3. Prototype demonstration of radiation therapy planning code system

    SciTech Connect (OSTI)

    Little, R.C.; Adams, K.J.; Estes, G.P.; Hughes, L.S. III; Waters, L.S.

    1996-09-01

    This is the final report of a one-year, Laboratory-Directed Research and Development project at the Los Alamos National Laboratory (LANL). Radiation therapy planning is the process by which a radiation oncologist plans a treatment protocol for a patient preparing to undergo radiation therapy. The objective is to develop a protocol that delivers sufficient radiation dose to the entire tumor volume, while minimizing dose to healthy tissue. Radiation therapy planning, as currently practiced in the field, suffers from inaccuracies made in modeling patient anatomy and radiation transport. This project investigated the ability to automatically model patient-specific, three-dimensional (3-D) geometries in advanced Los Alamos radiation transport codes (such as MCNP), and to efficiently generate accurate radiation dose profiles in these geometries via sophisticated physics modeling. Modem scientific visualization techniques were utilized. The long-term goal is that such a system could be used by a non-expert in a distributed computing environment to help plan the treatment protocol for any candidate radiation source. The improved accuracy offered by such a system promises increased efficacy and reduced costs for this important aspect of health care.

  4. Monthly Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2014 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  5. Monthly Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2015 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  6. Monthly Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2013 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  7. Monthly Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2012 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  8. Data Report

    Office of Legacy Management (LM)

    NDC 641 Results, Isotech Laboratories RESULTS REPORT RIN: 07081103 Site: Rulison Site Location: 35-12 Ticket Number: NDC 641 Report Date: 342008 Parameter Units Sample Date ID ...

  9. AUDIT REPORT

    Broader source: Energy.gov (indexed) [DOE]

    General SUBJECT: INFORMATION: Audit Report: "Security Improvements at the Y-12 ... In June 2004, the Office of Inspector General's report on Management of the Department's ...

  10. Reporting Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reporting Requirements Reporting Requirements Contacts Director Albert Migliori Deputy Franz Freibert 505 667-6879 Email Professional Staff Assistant Susan Ramsay 505 665 0858...

  11. Shape memory polymer foams for endovascular therapies (Patent...

    Office of Scientific and Technical Information (OSTI)

    polymer foams for endovascular therapies Title: Shape memory polymer foams for endovascular therapies A system for occluding a physical anomaly. One embodiment comprises a shape ...

  12. DOE Research Contributions to Radiation and Cancer Therapy

    Office of Scientific and Technical Information (OSTI)

    DOE Research Contributions to Radiation and Cancer Therapy Resources with Additional ... made many contributions to radiation and cancer therapy, including PEREGRINE and Boron ...

  13. Shape memory polymer foams for endovascular therapies (Patent...

    Office of Scientific and Technical Information (OSTI)

    Patent: Shape memory polymer foams for endovascular therapies Citation Details In-Document Search Title: Shape memory polymer foams for endovascular therapies A system for ...

  14. Rational design and adaptive management of combination therapies...

    Office of Scientific and Technical Information (OSTI)

    therapies for Hepatitis C virus infection Prev Next Title: Rational design and adaptive management of combination therapies for Hepatitis C virus infection Recent ...

  15. Rational Design and Adaptive Management of Combination Therapies...

    Office of Scientific and Technical Information (OSTI)

    of Combination Therapies for Hepatitis C Virus Infection CrossMark click for updates n ... Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection. ...

  16. Shape memory polymer foams for endovascular therapies (Patent...

    Office of Scientific and Technical Information (OSTI)

    Shape memory polymer foams for endovascular therapies Title: Shape memory polymer foams for endovascular therapies A system for occluding a physical anomaly. One embodiment ...

  17. Implementation of Remote 3-Dimensional Image Guided Radiation Therapy Quality Assurance for Radiation Therapy Oncology Group Clinical Trials

    SciTech Connect (OSTI)

    Cui Yunfeng; Galvin, James M.; Radiation Therapy Oncology Group, American College of Radiology, Philadelphia, Pennsylvania ; Parker, William; Breen, Stephen; Yin Fangfang; Cai Jing; Papiez, Lech S.; Li, X. Allen; Bednarz, Greg; Chen Wenzhou; Xiao Ying

    2013-01-01

    Purpose: To report the process and initial experience of remote credentialing of three-dimensional (3D) image guided radiation therapy (IGRT) as part of the quality assurance (QA) of submitted data for Radiation Therapy Oncology Group (RTOG) clinical trials; and to identify major issues resulting from this process and analyze the review results on patient positioning shifts. Methods and Materials: Image guided radiation therapy datasets including in-room positioning CT scans and daily shifts applied were submitted through the Image Guided Therapy QA Center from institutions for the IGRT credentialing process, as required by various RTOG trials. A centralized virtual environment is established at the RTOG Core Laboratory, containing analysis tools and database infrastructure for remote review by the Physics Principal Investigators of each protocol. The appropriateness of IGRT technique and volumetric image registration accuracy were evaluated. Registration accuracy was verified by repeat registration with a third-party registration software system. With the accumulated review results, registration differences between those obtained by the Physics Principal Investigators and from the institutions were analyzed for different imaging sites, shift directions, and imaging modalities. Results: The remote review process was successfully carried out for 87 3D cases (out of 137 total cases, including 2-dimensional and 3D) during 2010. Frequent errors in submitted IGRT data and challenges in the review of image registration for some special cases were identified. Workarounds for these issues were developed. The average differences of registration results between reviewers and institutions ranged between 2 mm and 3 mm. Large discrepancies in the superior-inferior direction were found for megavoltage CT cases, owing to low spatial resolution in this direction for most megavoltage CT cases. Conclusion: This first experience indicated that remote review for 3D IGRT as part of QA for RTOG clinical trials is feasible and effective. The magnitude of registration discrepancy between institution and reviewer was presented, and the major issues were investigated to further improve this remote evaluation process.

  18. Decision Regret in Men Undergoing Dose-Escalated Radiation Therapy for Prostate Cancer

    SciTech Connect (OSTI)

    Steer, Anna N.; Aherne, Noel J.; Gorzynska, Karen; Hoffman, Matthew; Last, Andrew; Hill, Jacques; Shakespeare, Thomas P.; Rural Clinical School Faculty of Medicine, University of New South Wales, Coffs Harbour

    2013-07-15

    Purpose: Decision regret (DR) is a negative emotion associated with medical treatment decisions, and it is an important patient-centered outcome after therapy for localized prostate cancer. DR has been found to occur in up to 53% of patients treated for localized prostate cancer, and it may vary depending on treatment modality. DR after modern dose-escalated radiation therapy (DE-RT) has not been investigated previously, to our knowledge. Our primary aim was to evaluate DR in a cohort of patients treated with DE-RT. Methods and Materials: We surveyed 257 consecutive patients with localized prostate cancer who had previously received DE-RT, by means of a validated questionnaire. Results: There were 220 responses (85.6% response rate). Image-guided intensity modulated radiation therapy was given in 85.0% of patients and 3-dimensional conformal radiation therapy in 15.0%. Doses received included 73.8 Gy (34.5% patients), 74 Gy (53.6%), and 76 Gy (10.9%). Neoadjuvant androgen deprivation (AD) was given in 51.8% of patients and both neoadjuvant and adjuvant AD in 34.5%. The median follow-up time was 23 months (range, 12-67 months). In all, 3.8% of patients expressed DR for their choice of treatment. When asked whether they would choose DE-RT or AD again, only 0.5% probably or definitely would not choose DE-RT again, compared with 8.4% for AD (P<.01). Conclusion: Few patients treated with modern DE-RT express DR, with regret appearing to be lower than in previously published reports of patients treated with radical prostatectomy or older radiation therapy techniques. Patients experienced more regret with the AD component of treatment than with the radiation therapy component, with implications for informed consent. Further research should investigate regret associated with individual components of modern therapy, including AD, radiation therapy and surgery.

  19. Nonclinical safety strategies for stem cell therapies

    SciTech Connect (OSTI)

    Sharpe, Michaela E.; Morton, Daniel; Rossi, Annamaria

    2012-08-01

    Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative diseases, inflammatory conditions, cancer and repair of damaged tissue. The safety of a stem cell therapy depends on many factors including the type of cell therapy, the differentiation status and proliferation capacity of the cells, the route of administration, the intended clinical location, long term survival of the product and/or engraftment, the need for repeated administration, the disease to be treated and the age of the population. Understanding the product profile of the intended therapy is crucial to the development of the nonclinical safety study design.

  20. Novel targeted therapy for stomach cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Novel targeted therapy for stomach cancer Novel targeted therapy for stomach cancer This finding has the potential to save thousand of lives a year by delivering a more effective, targeted treatment for cancer patients. November 1, 2015 New research at Los Alamos National Laboratory and the Wellcome Trust Sanger Institute shows a molecular fingerprint in stomach cancer that shows it can be treated with platinum drugs and/or molecular inhibitors known as PARP (poly ADP ribose polymerase). New

  1. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SANDIA REPORT SAND2014-4753 Unlimited Release Printed December 2014 Analysis of 100 SGIP ... NOTICE: This report was prepared as an account of work sponsored by an agency of the ...

  2. Data Report

    Office of Legacy Management (LM)

    NDC 644 Results, Paragon Analytics RESULTS REPORT RIN: 07081112 Site: Rulison Site Location: 35-32A Ticket Number: NDC 644 Report Date: 342008 Parameter Units Sample Date ID ...

  3. Annual Report

    Energy Savers [EERE]

    Information Act report covers the Period 10012009, through 09302010, as required by 5 U.S.C. 552. I. BASIC INFORMATION REGARDING REPORT 1. Kevin T. Hagerty, Director Office...

  4. Fast optimization and dose calculation in scanned ion beam therapy

    SciTech Connect (OSTI)

    Hild, S.; Graeff, C.; Trautmann, J.; Kraemer, M.; Zink, K.; Durante, M.; Bert, C.

    2014-07-15

    Purpose: Particle therapy (PT) has advantages over photon irradiation on static tumors. An increased biological effectiveness and active target conformal dose shaping are strong arguments for PT. However, the sensitivity to changes of internal geometry complicates the use of PT for moving organs. In case of interfractionally moving objects adaptive radiotherapy (ART) concepts known from intensity modulated radiotherapy (IMRT) can be adopted for PT treatments. One ART strategy is to optimize a new treatment plan based on daily image data directly before a radiation fraction is delivered [treatment replanning (TRP)]. Optimizing treatment plans for PT using a scanned beam is a time consuming problem especially for particles other than protons where the biological effective dose has to be calculated. For the purpose of TRP, fast optimization and fast dose calculation have been implemented into the GSI in-house treatment planning system (TPS) TRiP98. Methods: This work reports about the outcome of a code analysis that resulted in optimization of the calculation processes as well as implementation of routines supporting parallel execution of the code. To benchmark the new features, the calculation time for therapy treatment planning has been studied. Results: Compared to the original version of the TPS, calculation times for treatment planning (optimization and dose calculation) have been improved by a factor of 10 with code optimization. The parallelization of the TPS resulted in a speedup factor of 12 and 5.5 for the original version and the code optimized version, respectively. Hence the total speedup of the new implementation of the authors' TPS yielded speedup factors up to 55. Conclusions: The improved TPS is capable of completing treatment planning for ion beam therapy of a prostate irradiation considering organs at risk in this has been overseen in the review process. Also see below 6 min.

  5. A Treatment Planning Method for Sequentially Combining Radiopharmaceutical Therapy and External Radiation Therapy;External beam therapy; Radiopharmaceutical therapy; Three-dimensional dosimetry; Treatment planning

    SciTech Connect (OSTI)

    Hobbs, Robert F.; McNutt, Todd; Baechler, Sebastien; He Bin; Esaias, Caroline E.; Frey, Eric C.; Loeb, David M.; Wahl, Richard L.; Shokek, Ori; Sgouros, George

    2011-07-15

    Purpose: Effective cancer treatment generally requires combination therapy. The combination of external beam therapy (XRT) with radiopharmaceutical therapy (RPT) requires accurate three-dimensional dose calculations to avoid toxicity and evaluate efficacy. We have developed and tested a treatment planning method, using the patient-specific three-dimensional dosimetry package 3D-RD, for sequentially combined RPT/XRT therapy designed to limit toxicity to organs at risk. Methods and Materials: The biologic effective dose (BED) was used to translate voxelized RPT absorbed dose (D{sub RPT}) values into a normalized total dose (or equivalent 2-Gy-fraction XRT absorbed dose), NTD{sub RPT} map. The BED was calculated numerically using an algorithmic approach, which enabled a more accurate calculation of BED and NTD{sub RPT}. A treatment plan from the combined Samarium-153 and external beam was designed that would deliver a tumoricidal dose while delivering no more than 50 Gy of NTD{sub sum} to the spinal cord of a patient with a paraspinal tumor. Results: The average voxel NTD{sub RPT} to tumor from RPT was 22.6 Gy (range, 1-85 Gy); the maximum spinal cord voxel NTD{sub RPT} from RPT was 6.8 Gy. The combined therapy NTD{sub sum} to tumor was 71.5 Gy (range, 40-135 Gy) for a maximum voxel spinal cord NTD{sub sum} equal to the maximum tolerated dose of 50 Gy. Conclusions: A method that enables real-time treatment planning of combined RPT-XRT has been developed. By implementing a more generalized conversion between the dose values from the two modalities and an activity-based treatment of partial volume effects, the reliability of combination therapy treatment planning has been expanded.

  6. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... and Computer Engineering Georgia Institute of Technology 777 Atlantic Drive NW Atlanta, GA 30332-0250 Abstract The research presented in this report compares several real-time ...

  7. Special Report

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of any of the information or data contained in this Report. ... 2 1 - Introduction ...for the domestic uranium mining, conversion, and ...

  8. SPECIAL REPORT

    Broader source: Energy.gov (indexed) [DOE]

    Washington, DC 20585 September 3, 2015 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Special Report: "The Department of Energy's...

  9. Clinical Implementation of Intensity Modulated Proton Therapy for Thoracic Malignancies

    SciTech Connect (OSTI)

    Chang, Joe Y.; Li, Heng; Zhu, X. Ronald; Liao, Zhongxing; Zhao, Lina; Liu, Amy; Li, Yupeng; Sahoo, Narayan; Poenisch, Falk; Gomez, Daniel R.; Wu, Richard; Gillin, Michael; Zhang, Xiaodong

    2014-11-15

    Purpose: Intensity modulated proton therapy (IMPT) can improve dose conformality and better spare normal tissue over passive scattering techniques, but range uncertainties complicate its use, particularly for moving targets. We report our early experience with IMPT for thoracic malignancies in terms of motion analysis and management, plan optimization and robustness, and quality assurance. Methods and Materials: Thirty-four consecutive patients with lung/mediastinal cancers received IMPT to a median 66 Gy(relative biological equivalence [RBE]). All patients were able to undergo definitive radiation therapy. IMPT was used when the treating physician judged that IMPT conferred a dosimetric advantage; all patients had minimal tumor motion (<5 mm) and underwent individualized tumor-motion dose-uncertainty analysis and 4-dimensional (4D) computed tomographic (CT)-based treatment simulation and motion analysis. Plan robustness was optimized by using a worst-case scenario method. All patients had 4D CT repeated simulation during treatment. Results: IMPT produced lower mean lung dose (MLD), lung V{sub 5} and V{sub 20}, heart V{sub 40}, and esophageal V{sub 60} than did IMRT (P<.05) and lower MLD, lung V{sub 20}, and esophageal V{sub 60} than did passive scattering proton therapy (PSPT) (P<.05). D{sub 5} to the gross tumor volume and clinical target volume was higher with IMPT than with intensity modulated radiation therapy or PSPT (P<.05). All cases were analyzed for beam-angle-specific motion, water-equivalent thickness, and robustness. Beam angles were chosen to minimize the effect of respiratory motion and avoid previously treated regions, and the maximum deviation from the nominal dose-volume histogram values was kept at <5% for the target dose and met the normal tissue constraints under a worst-case scenario. Patient-specific quality assurance measurements showed that a median 99% (range, 95% to 100%) of the pixels met the 3% dose/3 mm distance criteria for the γ index. Adaptive replanning was used for 9 patients (26.5%). Conclusions: IMPT using 4D CT-based planning, motion management, and optimization was implemented successfully and met our quality assurance parameters for treating challenging thoracic cancers.

  10. Porphyrins for boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko; Gabel, Detlef

    1990-01-01

    Novel compounds for treatment of brain tumors in Boron Neutron Capture Therapy are disclosed. A method for preparing the compounds as well as pharmaceutical compositions containing said compounds are also disclosed. The compounds are water soluble, non-toxic and non-labile boronated porphyrins which show significant uptake and retention in tumors.

  11. Proton Therapy for Cancer: Current Status, Promise and Challenges...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    March 9, 2016, 4:15pm to 5:30pm Colloquia MBG Auditorium Proton Therapy for Cancer: Current Status, Promise and Challenges Dr. Dennis Mah ProCure Proton Therapy Center Colloquium...

  12. Microsoft PowerPoint - MBPCC CAMD Cancer Therapy Program, 12...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bird Perkins Cancer Center's CAMD Cancer Therapy Research Program CAMD Cancer Therapy Research Program Kenneth R Hogstrom, PhD, PI Chief of Physics Mary Bird Perkins Cancer Center...

  13. Annual Report

    Energy Savers [EERE]

    1 2011 Annual Report to the Oak Ridge Community Annual Report to the Oak Ridge Community DOE/ORO/2399 Progress Cleanup P Progress Cleanup P 2 This report was produced by URS | CH2M Oak Ridge LLC, DOE's Environmental Management contractor for the Oak Ridge Reservation. About the Cover After recontouring and revegetation, the P1 Pond at East Tennessee Technology Park is flourishing. The contaminated pond was drained, recontoured, and restocked with fish that would not disturb the pond sediment. 1

  14. COLLOQUIUM: Proton Therapy for Cancer: Current Status, Promise and

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Challenges | Princeton Plasma Physics Lab 25, 2016, 4:15pm to 5:30pm Colloquia MBG Auditorium, PPPL (284 cap.) COLLOQUIUM: Proton Therapy for Cancer: Current Status, Promise and Challenges Dr. Dennis Mah ProCure Proton Therapy Center This presentation will provide a physicist's perspective on a proton therapy for cancer treatment. It will include a context of how radiation therapy fits into cancer management overall with an emphasis on the differences between proton and conventional

  15. Report to congress on abnormal occurrences: January--March 1992

    SciTech Connect (OSTI)

    Not Available

    1992-07-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as abnormal occurrence as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to congress. This report covers the period from January 1 through March 31, 1992. The abnormal occurrences involving medical therapy misadministrations at NRC-licensed facilities are discussed in this report. There were no abnormal occurrences at a nuclear power plant, and none were reported by NRC's Agreement States. The report also contains information updating some previously reported abnormal occurrences.

  16. Special Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Report 193 Chemical Weekly June 16, 2015 T he Japanese rightly called them the seeds of ... occur in the same ore deposits as the lanthanides and exhibit similar chemical properties. ...

  17. AUDIT REPORT

    Office of Environmental Management (EM)

    Treatment of Salt Waste at the Savannah River Site OAS-L-15-09 August 2015 U.S. Department ... Audit Report: "Treatment of Salt Waste at the Savannah River Site" BACKGROUND The ...

  18. Final Report

    SciTech Connect (OSTI)

    Biros, George

    2014-08-18

    This the final report for the project "Large-Scale Optimization for Bayesian Inference in Complex Systems," for the work in the group of the co-PI George Biros.

  19. Final Report

    SciTech Connect (OSTI)

    DeTar, Carleton

    2012-12-10

    This document constitutes the Final Report for award DE-FC02-06ER41446 as required by the Office of Science. It summarizes accomplishments and provides copies of scientific publications with significant contribution from this award.

  20. Report2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DC, April 1983.) 8 a) R.P. Reed et al., "The Economic Effects of Fracture in the United States," (Part 1-A Synopsis of the September 30, 1982 Report to NBS by Battelle...

  1. Workshop Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    we do not know why. Complete Executive Summary (pdf) Read entire Final Report (pdf) LA-UR 10-02959 Research Needs for Material Mixing at Extremes (pdf) Image of the Cover of...

  2. Report to Congress on abnormal occurrences, October--December 1991

    SciTech Connect (OSTI)

    Not Available

    1992-03-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence of an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health and safety and requires a quarterly report of such events to be made to Congress. This report covers the period October through December 1991. Five abnormal occurrences at NRC-licensed facilities are discussed in this report. None of these occurrences involved a nuclear power plant. Four involved medical therapy misadministrations and one involved a medical diagnostic misadministration. The NRC's Agreement States reported three abnormal occurrences. Two involved exposures of non-radiation workers and one involved a medical therapy misadministration. The report also contains information that updates some previously reported abnormal occurrences.

  3. FINAL REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FINAL REPORT AEC-ERDA Research Contract AT (11-1) 2174 Columbia University's Nevis Laboratories "Research in Neutron Velocity Spectroscopy" James RainwatGr DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency Thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or

  4. FINAL REPORT

    Office of Scientific and Technical Information (OSTI)

    FINAL REPORT Analytical and Elemental Analysis of Air and Soil Samples Facility and Public Awareness Partnership (Training/Public Awareness) Congressionally Awarded Grant No. DE-FG02-05ER64045 Submitted to: U.S. Department of Energy Attn: William Henson Submitted by: Alabama A&M University Research Institute (AAMURI) [pic] October 1, 2007 This report reflects a joint training program at the Integrated Environmental Research and Services (IERS) of the Alabama A&M University Research

  5. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    REPORT SAND 2011-3958 Unlimited Release Printed June 2011 Site Environmental Report for 2010 Sandia National Laboratories, California B.L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000. Approved for

  6. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Study of the Use of Deep Saline Formations for Combined Thermoelectric Power Plant Water Needs and Carbon Sequestration at a Regional- Scale: Phase I Report. June, 2008 Disclaimer This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or

  7. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5-0587 Unlimited Release January 2015 Precursor Report of Data Needs and Recommended Practices for PV Plant Availability, Operations and Maintenance Reporting Roger R Hill, Geoffrey Klise; Sandia National Laboratories John R Balfour, High Performance PV Prepared by Roger Hill Sandia National Laboratories Albuquerque, New Mexico 87185 and Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of

  8. SPECIAL REPORT

    Energy Savers [EERE]

    SPECIAL REPORT Enforcement Activities Conducted by the Federal Energy Regulatory Commission DOE/IG-0947 September 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 September 29, 2015 MEMORANDUM FOR THE CHAIRMAN, FEDERAL ENERGY REGULATORY COMMISSION FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Special Report: "Enforcement Activities Conducted by the Federal Energy Regulatory

  9. Reporting Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reporting Requirements Reporting Requirements Contacts Director Albert Migliori Deputy Franz Freibert 505 667-6879 Email Professional Staff Assistant Susan Ramsay 505 665 0858 Email The Fellow will be required to participate in the Actinide Science lecture series by both attending lectures and presenting a scientific lecture on actinide science in this series. Submission of a viewgraph and brief write-up of the project. Provide metrics information as requested. Submission of an overview article

  10. Final Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Final Report Document Number 11123-23.Final Field Demonstration of Eco-Friendly Creation of Propped Hydraulic Fractures Contract Number: 11123-23.Final February 16, 2015 Nadji Benrabah (Author) Engineer CSI Technologies 1930 W.W. Thorne Dr. Houston, TX 77073 Phil Van Trump (Principal Investigator) Chief Technology Officer DaniMer Scientific, LLC 1301 Colquitt Highway Bainbridge, GA 39817 2 LEGAL NOTICE This report was prepared by DaniMer Scientific, LLC as an account of work sponsored by the

  11. Usage Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reports Usage Reports Batch Job Statistics See queue wait times, hours used, top users and other summary statistics for jobs run at NERSC (login required). Read More » Parallel Job Statistics (Cray aprun) [rest... Read More » Historical Data Edison Job Size Charts Fraction of Hours Used per Job Size Note: Interactive charts with current and past Cori and Edison data are now available on MyNERSC This chart shows the fraction of hours used on Edison in each of 5 job-core-size bins. 2015 2014

  12. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    .VUQ.SAUQ.P6.02; Apply VUQ Practices With Dakota to COBRA-TF for AMA-Relevant Problems Vincent Mousseau Brian Adams Kostadin Ivanov Maria Avramova Robert Salko Taylor Blyth Sandia National Laboratories April 2013: CASL-U-2013-0048-000 SANDIA REPORT SAND2013-3093 Unlimited Release Printed April 2013 CASL L3 Milestone Report: L3:VUQ.SAUQ.P6.02; Apply VUQ Practices with Dakota to COBRA-TF for AMA-Relevant Problems Vincent Mousseau Brian Adams Kostadin Ivanov Maria Avramova Robert Salko Taylor Blyth

  13. Annual Report

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    09 THROUGH 09/30/2010 The following Annual Freedom of Information Act report covers the Period 10/01/2009, through 09/30/2010, as required by 5 U.S.C. 552. I. BASIC INFORMATION REGARDING REPORT 1. Kevin T. Hagerty, Director Office of Information Resources, MA-90 U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 202-586-5955 Alexander Morris, FOIA Officer Sheila Jeter, FOIA/Privacy Act Specialist FOIA Office, MA-90 Office of Information Resources U.S. Department of Energy

  14. Lidar Report

    SciTech Connect (OSTI)

    Wollpert.

    2009-04-01

    This report provides an overview of the LiDAR acquisition methodology employed by Woolpert on the 2009 USDA - Savannah River LiDAR Site Project. LiDAR system parameters and flight and equipment information is also included. The LiDAR data acquisition was executed in ten sessions from February 21 through final reflights on March 2, 2009; using two Leica ALS50-II 150kHz Multi-pulse enabled LiDAR Systems. Specific details about the ALS50-II systems are included in Section 4 of this report.

  15. Audit Report: IG-0709 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    9 Audit Report: IG-0709 November 17, 2005 Management of the Department's Isotope Program Dating back to the Atomic Energy Act of 1954, the Development Isotopes Department of Energy's (Department) predecessor agency, the Atomic Energy Commission, was authorized to distribute stable and radioactive isotopes at no charge to assist and encourage research on peaceful uses of isotopes involving medical therapy. More recently, the 1990 Energy and Water Appropriations Act consolidated all isotope

  16. Activity report

    SciTech Connect (OSTI)

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  17. Occurrence Reporting

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-09-25

    To establish and maintain a system for reporting operations information related to DOE-owned or -operated facilities and processing that information to identify the root causes of Unusual, Off-Normal, and Emergency Occurrences and provide for appropriate corrective action. Cancels DOE 5000.3B.

  18. Cost-Effectiveness Analysis of Intensity Modulated Radiation Therapy Versus 3-Dimensional Conformal Radiation Therapy for Anal Cancer

    SciTech Connect (OSTI)

    Hodges, Joseph C.; Beg, Muhammad S.; Das, Prajnan; Meyer, Jeffrey

    2014-07-15

    Purpose: To compare the cost-effectiveness of intensity modulated radiation therapy (IMRT) and 3-dimensional conformal radiation therapy (3D-CRT) for anal cancer and determine disease, patient, and treatment parameters that influence the result. Methods and Materials: A Markov decision model was designed with the various disease states for the base case of a 65-year-old patient with anal cancer treated with either IMRT or 3D-CRT and concurrent chemotherapy. Health states accounting for rates of local failure, colostomy failure, treatment breaks, patient prognosis, acute and late toxicities, and the utility of toxicities were informed by existing literature and analyzed with deterministic and probabilistic sensitivity analysis. Results: In the base case, mean costs and quality-adjusted life expectancy in years (QALY) for IMRT and 3D-CRT were $32,291 (4.81) and $28,444 (4.78), respectively, resulting in an incremental cost-effectiveness ratio of $128,233/QALY for IMRT compared with 3D-CRT. Probabilistic sensitivity analysis found that IMRT was cost-effective in 22%, 47%, and 65% of iterations at willingness-to-pay thresholds of $50,000, $100,000, and $150,000 per QALY, respectively. Conclusions: In our base model, IMRT was a cost-ineffective strategy despite the reduced acute treatment toxicities and their associated costs of management. The model outcome was sensitive to variations in local and colostomy failure rates, as well as patient-reported utilities relating to acute toxicities.

  19. The effects of interstitial atoms H and B on magnetic properties and magnetocaloric effect in LaFe{sub 11.5}Al{sub 1.5} compound

    SciTech Connect (OSTI)

    Zhang, D. K.; Zhao, J. L.; Shen, J.; Zhang, H. G.; Yue, M.

    2014-05-14

    The changes in magnetic properties of LaFe{sub 11.5}Al{sub 1.5}H{sub x} and LaFe{sub 11.5}Al{sub 1.5}B{sub y} have been investigated. By introducing interstitial atoms H or B, the magnetic ground state is changed from the antiferromagnetic to the ferromagnetic state, accompanied by significant increases in the saturated magnetization (Ms) and the Curie temperature (T{sub C}). An attractive feature is that the magnetic transition from the second-order to the weakly first-order with increasing hydrogen content compared to the magnetic transition from the weakly first-order to the second-order with increasing boron content. The maximum magnetic entropy change (−ΔS{sub M}) under a field change of 0–5 T increases from 10.1 J/kg · K for hydrogen content x = 0.12 to 12.3 J/kg · K for x = 1.3, while decreases from 9.6 J/kg · K for boron content y = 0.1 to 9.2 J/kg · K for y = 0.3.

  20. ASSESSMENT REPORT

    Energy Savers [EERE]

    & Wilcox Technical Services Pantex LLC During Fiscal Year 2013 Through June 30, 2014, Under Department of Energy Contract No. DE-AC54-00AL66620 OAI-V-16-04 February 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 February 12, 2016 MEMORANDUM FOR THE MANAGER, NNSA PRODUCTION OFFICE FROM: David Sedillo, Director Western Audits Division Office of Inspector General SUBJECT: INFORMATION: Assessment Report on

  1. AUDIT REPORT

    Energy Savers [EERE]

    AU Organization Chart AU Organization Chart AU Organization Chart: December 22, 2015 PDF icon AU Organization Chart: December 22, 2015 More Documents & Publications FTCP Senior Technical Safety Manager (STSM) Status Report USW Health Safety and Environment Conference - HSS Workshop Organizational Chart

    Management of the Startup of the Sodium-Bearing Waste Treatment Facility DOE-OIG-16-09 March 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections

  2. AUDIT REPORT

    Energy Savers [EERE]

    and Oversight of Information Technology Contracts at the Department of Energy's Hanford Site DOE-OIG-16-10 April 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 April 1, 2016 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Audit Report on the "Management and Oversight of Information Technology Contracts at the Department of Energy's Hanford Site"

  3. Final Report

    Office of Scientific and Technical Information (OSTI)

    Internal magnetic field, temperature, and density measurements on magnetized HED plasmas using Pulsed Polarimetry DOE Grant ER55034, UW grant # 61-9515 - High Energy Density, Office of Fusion Science Roger J Smith (PI) Dept. Aeronautics and Astronautics, University of Washington, Seattle, Wa 98195 smith@aa.washington.edu, 206 543 6323 (AA grants administrator) June 11, 2014 Report submitted to: Formerly Dr. Francis Thio Program Manager, DOE Office of Fusion Energy Sciences Nominal Grant Period:

  4. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3-3735 Unlimited Release Printed June 2013 Site Environmental Report for 2012 Sandia National Laboratories, California Barbara L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Approved for public

  5. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4-4161 Unlimited Release Printed June 2014 Site Environmental Report for 2013 Sandia National Laboratories, California Barbara L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Approved for public

  6. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2-4417 Unlimited Release Printed June 2012 Site Environmental Report for 2011 Sandia National Laboratories, California B.L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000. Approved for public release,

  7. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5-4277 Unlimited Release Printed June 2015 Site Environmental Report for 2014 Sandia National Laboratories, California Barbara L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Approved for public

  8. SANDIA REPORT

    Energy Savers [EERE]

    Russel Edge About Us Russel Edge Team Leader, Uranium Mine Team Russel Edge became an LM staff member on November 2, 2014, as a Business Management Specialist in the Westminster, Colorado, office. He reports directly to the DOE Office of Site Operations Director. Prior to joining LM, Russel was employed by the National Nuclear Security Administration Sandia field office in Albuquerque, New Mexico, as a program manager for the Laboratory Directed Research and Development (LDRD) program and point

  9. AUDIT REPORT

    Energy Savers [EERE]

    Management of Information Technology Hardware DOE/IG-0926 October 2014 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 October 30, 2014 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Audit Report on "Follow-up on the Department of Energy's Management of Information Technology Hardware" BACKGROUND The Department of Energy and its facility contractors rely on

  10. AUDIT REPORT

    Energy Savers [EERE]

    Management of High-Risk Excess Facilities DOE/IG-0931 January 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 January 23, 2015 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Audit Report on "The Department of Energy's Management of High-Risk Excess Facilities" BACKGROUND Fifty years of nuclear weapons production and energy research during the Manhattan

  11. AUDIT REPORT

    Energy Savers [EERE]

    Procurement of Parts and Materials for the Waste Treatment and Immobilization Plant at the Hanford Site DOE-OIG-16-03 November 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 November 17, 2015 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Audit Report: "Procurement of Parts and Materials for the Waste Treatment and Immobilization Plant at the Hanford

  12. AUDIT REPORT

    Energy Savers [EERE]

    5 Consolidated Financial Statements OAI-FS-16-01 November 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 November 16, 2015 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Audit Report: "Department of Energy's Fiscal Year 2015 Consolidated Financial Statements" Pursuant to requirements established by the Government Management Reform Act of 1994, the

  13. AUDIT REPORT

    Energy Savers [EERE]

    Issues Management at the Los Alamos Field Office OAI-M-16-02 December 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 December 7, 2015 MEMORANDUM FOR THE MANAGER, LOS ALAMOS FIELD OFFICE FROM: Daniel M. Weeber Assistant Inspector General for Audits and Administration Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Issues Management at the Los Alamos Field Office" BACKGROUND The

  14. AUDIT REPORT

    Energy Savers [EERE]

    Audit of the Department of Energy's Management of Contractor Fines, Penalties, and Legal Costs DOE-OIG-16-06 February 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 February 5, 2016 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Audit Report on the "Followup Audit of the Department of Energy's Management of Contractor Fines, Penalties, and Legal

  15. AUDIT REPORT

    Energy Savers [EERE]

    Corrective Action Program at the Waste Treatment and Immobilization Plant OAI-M-16-06 February 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 February 1, 2016 MEMORANDUM FOR THE ASSISTANT SECRETARY FOR ENVIRONMENTAL MANAGEMENT FROM: George Collard Deputy Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on the "Corrective Action Program at the

  16. AUDIT REPORT

    Energy Savers [EERE]

    National Laboratory DOE-OIG-16-07 February 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 February 25, 2016 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Audit Report on "Issues Management at the Los Alamos National Laboratory" BACKGROUND The Department of Energy's Los Alamos National Laboratory (LANL) is part of the National Nuclear Security

  17. Annual Report

    Energy Savers [EERE]

    Report Fiscal Year 2011 Office of Environment, Security, Safety and Health The Office of Fossil Energy: Striving for Environmental, Security, Safety and Health (ESS&H) and Sustainability Excellence I The Department of Energy's Office of Fossil Energy (FE) is dedicated to ensuring that the nation can continue to rely on traditional resources for clean, affordable energy while enhancing sustainability across its three sites: the Strategic Petroleum Reserve (SPR), the National Energy Technology

  18. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12 Unlimited Release Printed December 2014 PV Reliability Operations and Maintenance (PVROM) Database Initiative: 2014 Progress Report Geoffrey T. Klise, Roger R. Hill, Colin J. Hamman, Peter H. Kobos, Vipin Gupta, Benjamin B. Yang, Sandia National Laboratories Nadav Enbar, Electric Power Research Institute Prepared by Sandia National Laboratories Albuquerque, New Mexico 87185 and Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by

  19. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4778 Unlimited Release July 2011 Utility-Scale Grid-Tied PV Inverter Reliability Workshop Summary Report Stanley Atcitty, Jennifer E. Granata, Michael A. Quintana, Coryne A. Tasca Prepared by Sandia National Laboratories Albuquerque, New Mexico 87185 and Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear

  20. SANDIA REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    09 Unlimited Release SAND2010-7245P Printed October 2010 Annual Groundwater Monitoring Report Prepared by Sandia National Laboratories, Albuquerque, New Mexico Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Approved for public release; further dissemination unlimited Issued

  1. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    5 Consolidated Financial Statements OAI-FS-16-01 November 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 November 16, 2015 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Audit Report: "Department of Energy's Fiscal Year 2015 Consolidated Financial Statements" Pursuant to requirements established by the Government Management Reform Act of 1994, the

  2. SPECIAL REPORT

    Energy Savers [EERE]

    The Department of Energy's Freedom of Information Act Process DOE/IG-0946 September 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 September 18, 2015 MEMORANDUM FOR THE DIRECTOR, OFFICE OF MANAGEMENT FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Special Report: "The Department of Energy's Freedom of Information Act Process" BACKGROUND The Freedom of Information Act (FOIA or the

  3. SPECIAL REPORT

    Energy Savers [EERE]

    Management Challenges at the Department of Energy - Fiscal Year 2016 OIG-SR-16-01 November 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 November 16, 2015 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Special Report: "Management Challenges at the Department of Energy - Fiscal Year 2016" INTRODUCTION The Department of Energy is responsible for some

  4. CRD Report

    SciTech Connect (OSTI)

    Wang, Ucilia

    2007-12-18

    This report has the following articles: (1) Deconstructing Microbes--metagenomic research on bugs in termites relies on new data analysis tools; (2) Popular Science--a nanomaterial research paper in Nano Letters drew strong interest from the scientific community; (3) Direct Approach--researchers employ an algorithm to solve an energy-reduction issue essential in describing complex physical system; and (4) SciDAC Special--A science journal features research on petascale enabling technologies.

  5. Final Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cyber Security for Utility Operations NETL Project M63SNL34 Sponsored by the U.S. DOE Office of Energy Assurance Managed by NETL Final Report Period of Performance October, 2003 - April, 2005 Dennis Holstein and John Tengdin, OPUS Publishing Jay Wack and Roger Butler, TecSec, Inc. Timothy Draelos, Sandia National Laboratories 1 Paul Blomgren, SafeNet/Mykotronx April 18, 2005 1 Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States

  6. Gantry for medical particle therapy facility

    DOE Patents [OSTI]

    Trbojevic, Dejan

    2012-05-08

    A particle therapy gantry for delivering a particle beam to a patient includes a beam tube having a curvature defining a particle beam path and a plurality of fixed field magnets sequentially arranged along the beam tube for guiding the particle beam along the particle path. In a method for delivering a particle beam to a patient through a gantry, a particle beam is guided by a plurality of fixed field magnets sequentially arranged along a beam tube of the gantry and the beam is alternately focused and defocused with alternately arranged focusing and defocusing fixed field magnets.

  7. Gantry for medical particle therapy facility

    DOE Patents [OSTI]

    Trbojevic, Dejan

    2013-04-23

    A particle therapy gantry for delivering a particle beam to a patient includes a beam tube having a curvature defining a particle beam path and a plurality of superconducting, variable field magnets sequentially arranged along the beam tube for guiding the particle beam along the particle path. In a method for delivering a particle beam to a patient through a gantry, a particle beam is guided by a plurality of variable field magnets sequentially arranged along a beam tube of the gantry and the beam is alternately focused and defocused with alternately arranged focusing and defocusing variable field magnets.

  8. Acceleration Of Wound Healing Ny Photodynamic Therapy

    DOE Patents [OSTI]

    Hasan, Tayyaba; Hamblin, Michael R.; Trauner, Kenneth

    2000-08-22

    Disclosed is a method for accelerating wound healing in a mammal. The method includes identifying an unhealed wound site or partially-healed wound site in a mammal; administering a photosensitizer to the mammal; waiting for a time period wherein the photosensitizer reaches an effective tissue concentration at the wound site; and photoactivating the photosensitizer at the wound site. The dose of photodynamic therapy is selected to stimulate the production of one or more growth factor by cells at the wound site, without causing tissue destruction.

  9. Oct. 25 Lecture Highlights Treatment Technology of HU's Proton Therapy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Institute | Jefferson Lab Oct. 25 Lecture Highlights Treatment Technology of HU's Proton Therapy Institute Oct. 25 Lecture Highlights Treatment Technology of HU's Proton Therapy Institute Cynthia Keppel Hampton University Proton Therapy Institute Scientific and Technical Director, Cynthia Keppel, will present a public lecture titled "Accelerating Protons to Save Lives" on Oct. 25 at Jefferson Lab in Newport News. NEWPORT NEWS, Va., Sept. 29, 2011 - Jefferson Lab's 2011 Fall Science

  10. Metalloporphyrins and their uses as radiosensitizers for radiation therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    2004-07-06

    The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron--capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.

  11. Methods for implementing microbeam radiation therapy

    DOE Patents [OSTI]

    Dilmanian, F. Avraham; Morris, Gerard M.; Hainfeld, James F.

    2007-03-20

    A method of performing radiation therapy includes delivering a therapeutic dose such as X-ray only to a target (e.g., tumor) with continuous broad beam (or in-effect continuous) using arrays of parallel planes of radiation (microbeams/microplanar beams). Microbeams spare normal tissues, and when interlaced at a tumor, form a broad-beam for tumor ablation. Bidirectional interlaced microbeam radiation therapy (BIMRT) uses two orthogonal arrays with inter-beam spacing equal to beam thickness. Multidirectional interlaced MRT (MIMRT) includes irradiations of arrays from several angles, which interleave at the target. Contrast agents, such as tungsten and gold, are administered to preferentially increase the target dose relative to the dose in normal tissue. Lighter elements, such as iodine and gadolinium, are used as scattering agents in conjunction with non-interleaving geometries of array(s) (e.g., unidirectional or cross-fired (intersecting) to generate a broad beam effect only within the target by preferentially increasing the valley dose within the tumor.

  12. Reducing the uncertainties in particle therapy

    SciTech Connect (OSTI)

    Oancea, C.; Shipulin, K. N.; Mytsin, G. V.; Luchin, Y. I.

    2015-02-24

    The use of fundamental Nuclear Physics in Nuclear Medicine has a significant impact in the fight against cancer. Hadrontherapy is an innovative cancer radiotherapy method using nuclear particles (protons, neutrons and ions) for the treatment of early and advanced tumors. The main goal of proton therapy is to deliver high radiation doses to the tumor volume with minimal damage to healthy tissues and organs. The purpose of this work was to investigate the dosimetric errors in clinical proton therapy dose calculation due to the presence of metallic implants in the treatment plan, and to determine the impact of the errors. The results indicate that the errors introduced by the treatment planning systems are higher than 10% in the prediction of the dose at isocenter when the proton beam is passing directly through a metallic titanium alloy implant. In conclusion, we recommend that pencil-beam algorithms not be used when planning treatment for patients with titanium alloy implants, and to consider implementing methods to mitigate the effects of the implants.

  13. ASSESSMENT REPORT

    Energy Savers [EERE]

    Alliance for Sustainable Energy LLC During Fiscal Years 2012 and 2013 Under Department of Energy Contract No. DE-AC36-08GO28308 OAI-V-16-06 March 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 March 11, 2016 MEMORANDUM FOR THE DIRECTOR, GOLDEN FIELD OFFICE FROM: Jack Rouch Deputy Assistant Inspector General for Audits Office of Inspector General SUBJECT: INFORMATION: Assessment Report on "Audit Coverage

  14. ASSESSMENT REPORT

    Energy Savers [EERE]

    Stanford University During Fiscal Years 2012 and 2013 Under Department of Energy Contract No. DE-AC02-76SF00515 OAS-V-15-04 September 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 September 21, 2015 MEMORANDUM FOR THE MANAGER, SLAC SITE OFFICE FROM: David Sedillo, Director Western Audits Division Office of Inspector General SUBJECT: INFORMATION: Assessment Report: "Audit Coverage of Cost Allowability for

  15. ASSESSMENT REPORT

    Energy Savers [EERE]

    Brookhaven Science Associates LLC During Fiscal Years 2012 and 2013 Under Department of Energy Contract No. DE-AC02-98CH10886 OAI-V-16-03 January 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 January 19, 2016 MEMORANDUM FOR THE MANAGER, BROOKHAVEN SITE OFFICE FROM: Jack Rouch, Director Central Audits Division Office of Inspector General SUBJECT: INFORMATION: Assessment Report: "Audit Coverage of Cost

  16. TECHNICAL REPORT

    Office of Scientific and Technical Information (OSTI)

    TECHNICAL REPORT September 1 through November 30, 1994 Project Title: MANUFACTURE OF AMMONIUM SULFATE FERTILIZER FROM FGD-GYPSUM ICCI Project Number: Principal Investigator: Other Investigators: Project Manager; DOE Cooperative Agreement Number: DE-FC22-92PC9252 1 (Year 3) 94-1/3.1B-3M M.4.M. Chou, Illinois State Geological Survey (ISGS) M. Rostam-Abadi and J.M. Lytle, ISGS R. Hoeft, University of Illinois; EZ. Blevins, Allied Signal-Chemicals; F. Achron, Southeast Marketing Chemical Process

  17. ASSESSMENT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ASSESSMENT REPORT Audit Coverage of Cost Allowability for National Security Technologies LLC During Fiscal Years 2012 Through 2014 Under Department of Energy Contract No. DE-AC52-06NA25946 OAI-V-16-07 April 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 April 12, 2016 MEMORANDUM FOR THE MANAGER, NEVADA FIELD OFFICE FROM: David Sedillo Deputy Assistant Inspector General for Audits and Inspections Office of

  18. ONTRACTOR REPORT

    Office of Scientific and Technical Information (OSTI)

    ONTRACTOR REPORT S A N D 8 2 -7 0 5 6 Unlimited Release Peer-Review Study of the Draft Handbook for Human-Reliability Analysis With Emphasis on Nuclear-Power- Plant Applications, NUREG/CR-1278 R. L. Brune, M. Weinstein, M. E. Fitzwater Human Performance Technologies, Inc. P.O. Box 3816 Thousand Oaks, CA 91359 Prepared by Sandia National Laboratories Albuquerque, New Mexico 87185 and Livermore, California 94550 for the United States D epartment of Energy under Contract DE-AC04-76DR00789 Printed

  19. Trip Report

    Office of Legacy Management (LM)

    Site A/Plot M, Cook County, Illinois May 2013 Page 1 2013 Inspection and Annual Site Status Report for the Site A/Plot M, Cook County, Illinois Decontamination and Decommissioning Program Site Summary Site A/Plot M was inspected on April 10, 2013. The site, located within a county forest preserve with significant tree and grass cover, was in good condition. No cause for a follow-up inspection was identified. Erosion on top of the grass covered mound at Plot M continues to be a concern. Bike

  20. Final Report

    SciTech Connect (OSTI)

    R Paul Drake

    2004-01-12

    OAK-B135 This is the final report from the project Hydrodynamics by High-Energy-Density Plasma Flow and Hydrodynamics and Radiation Hydrodynamics with Astrophysical Applications. This project supported a group at the University of Michigan in the invention, design, performance, and analysis of experiments using high-energy-density research facilities. The experiments explored compressible nonlinear hydrodynamics, in particular at decelerating interfaces, and the radiation hydrodynamics of strong shock waves. It has application to supernovae, astrophysical jets, shock-cloud interactions, and radiative shock waves.

  1. Cytometric Therapies for Cell Delivery - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Materials Advanced Materials Find More Like This Return to Search Cytometric Therapies for Cell Delivery Maximizing Efficacy of Cell Delivery Oak Ridge National Laboratory ...

  2. Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL...

    Office of Science (SC) Website

    Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Applications of Nuclear ...

  3. Final Report

    SciTech Connect (OSTI)

    Webb, Robert C.; Kamon, Teruki; Toback, David; Safonov, Alexei; Dutta, Bhaskar; Dimitri, Nanopoulos; Pope, Christopher; White, James

    2013-11-18

    Overview The High Energy Physics Group at Texas A&M University is submitting this final report for our grant number DE-FG02-95ER40917. This grant has supported our wide range of research activities for over a decade. The reports contained here summarize the latest work done by our research team. Task A (Collider Physics Program): CMS & CDF Profs. T. Kamon, A. Safonov, and D. Toback co-lead the Texas A&M (TAMU) collider program focusing on CDF and CMS experiments. Task D: Particle Physics Theory Our particle physics theory task is the combined effort of Profs. B. Dutta, D. Nanopoulos, and C. Pope. Task E (Underground Physics): LUX & NEXT Profs. R. Webb and J. White(deceased) lead the Xenon-based underground research program consisting of two main thrusts: the first, participation in the LUX two-phase xenon dark matter search experiment and the second, detector R&D primarily aimed at developing future detectors for underground physics (e.g. NEXT and LZ).

  4. Final Report

    SciTech Connect (OSTI)

    Gurney, Kevin R

    2015-01-12

    This document constitutes the final report under DOE grant DE-FG-08ER64649. The organization of this document is as follows: first, I will review the original scope of the proposed research. Second, I will present the current draft of a paper nearing submission to Nature Climate Change on the initial results of this funded effort. Finally, I will present the last phase of the research under this grant which has supported a Ph.D. student. To that end, I will present the graduate student’s proposed research, a portion of which is completed and reflected in the paper nearing submission. This final work phase will be completed in the next 12 months. This final workphase will likely result in 1-2 additional publications and we consider the results (as exemplified by the current paper) high quality. The continuing results will acknowledge the funding provided by DOE grant DE-FG-08ER64649.

  5. Final Report

    SciTech Connect (OSTI)

    Yelton, John Martin; Mitselmakher, Guenakh; Korytov, Andrey; Avery, Paul; Furic, Ivan; Acosta, Darin; Konigsberg, Jacobo; Field, Richard; Matchev, Konstantin; Ramond, Pierre; Thorn, Richard; Sikivie, Pierre; Ray, Heather; Tanner, David

    2013-10-10

    We report on progress in a series of different directions within high energy physics research. 1. Neutrino research in hardware and software on the Minerva and MiniBooNE experiments 2. Experimental particle physics at the hadron colliders, with emphasis on research and development and data analysis on the CMS experiment operating at the CERN LHC. This includes research on the discovery and properties on the Higgs Boson. 3. Educational outreach through the Quarknet program, taking physics research into High School classrooms. 4. Theoretical and Phenomenological High Energy research, covering a broad range of activities ranging from fundamental theoretical issues to areas of immediate phenomenological importance. 5. Experiment searches for the Axion, as part of the ADMX experiment.

  6. Cognos Reporting & Self Service

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reporting & Self Service

  7. Intraoperative radiation therapy in recurrent ovarian cancer

    SciTech Connect (OSTI)

    Yap, O.W. Stephanie . E-mail: stbeast@stanford.edu; Kapp, Daniel S.; Teng, Nelson N.H.; Husain, Amreen

    2005-11-15

    Purpose: To evaluate disease outcomes and complications in patients with recurrent ovarian cancer treated with cytoreductive surgery and intraoperative radiation therapy (IORT). Methods and Materials: A retrospective study of 24 consecutive patients with ovarian carcinoma who underwent secondary cytoreduction and intraoperative radiation therapy at our institution between 1994 and 2002 was conducted. After optimal cytoreductive surgery, IORT was delivered with orthovoltage X-rays (200 kVp) using individually sized and beveled cone applications. Outcomes measures were local control of disease, progression-free interval, overall survival, and treatment-related complications. Results: Of these 24 patients, 22 were available for follow-up analysis. Additional treatment at the time of and after IORT included whole abdominopelvic radiation, 9; pelvic or locoregional radiation, 5; chemotherapy, 6; and no adjuvant treatment, 2. IORT doses ranged from 9-14 Gy (median, 12 Gy). The anatomic sites treated were pelvis (sidewalls, vaginal cuff, presacral area, anterior pubis), para-aortic and paracaval lymph node beds, inguinal region, or porta hepatitis. At a median follow-up of 24 months, 5 patients remain free of disease, whereas 17 patients have recurred, of whom 4 are alive with disease and 13 died from disease. Five patients recurred within the radiation fields for a locoregional relapse rate of 32% and 12 patients recurred at distant sites with a median time to recurrence of 13.7 months. Five-year overall survival was 22% with a median survival of 26 months from time of IORT. Nine patients (41%) experienced Grade 3 toxicities from their treatments. Conclusion: In carefully selected patients with locally recurrent ovarian cancer, combined IORT and tumor reductive surgery is reasonably tolerated and may contribute to achieving local control and disease palliation.

  8. Endoscopic Electron-Beam Cancer Therapy | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Endoscopic Electron-Beam Cancer Therapy Technology available for licensing: A successful and cost-effective means of treating cancer in previously inoperable or radiation-sensitive areas of the body. Cost-effective Can treat cancer in inoperable or radiation-sensitive areas PDF icon e-beam_cancer_therapy

  9. Final report

    SciTech Connect (OSTI)

    Joseph H. Simmons; Tracie J. Bukowski

    2002-08-07

    This grant was a continuation of research conducted at the University of Florida under Grant No. DE-FG05-91ER45462 in which we investigated the energy bandgap shifts produced in semiconductor quantum dots of sizes between 1.5 and 40 nm. The investigated semiconductors consisted of a series of Column 2-6 compounds (CdS, CdSe, CdTe) and pure Column IV elements (Si and Ge). It is well-known of course that the 2-6 semiconductors possess a direct-gap electronic structure, while the Column IV elements possess an indirect-gap structure. The investigation showed a major difference in quantum confinement behavior between the two sets of semiconductors. This difference is essentially associated with the change in bandgap energy resulting from size confinement. In the direct-gap semiconductors, the change in energy (blue shift) saturates when the crystals approach 2-3 nm in diameter. This limits the observed shift in energy to less than 1 eV above the bulk value. In the indirect-gap semiconductors, the energy shift does not show any sign of saturation and in fact, we produced Si and Ge nanocrystals with absorption edges in the UV. The reason for this difference has not been determined and will require additional experimental and theoretical studies. In our work, we suggest, but do not prove that mixing of conduction band side valleys with the central valley under conditions of size confinement may be responsible for the saturation in the blue-shift of direct-gap semiconductors. The discovery of large bandgap energy shifts with crystal size prompted us to suggest that these materials may be used to form photovoltaic cells with multi-gap layers for high efficiency in a U.S. Patent issued in 1998. However, this possibility depends strongly on the ability to collect photoexcited carriers from energy-confined crystals. The research conducted at the University of Arizona under the subject grant had a major goal of testing an indirect gap semiconductor in size-confined structures to determine if photocarriers could be collected. Thus, we tested a variety of semiconductor-glass nano-composite structures for photoconductivity. Tests were conducted in collaboration with the Laser Physics Division at Sandia National Laboratories. Nano-composite samples were formed consisting of Ge nanocrystals embedded in an indium-tin-oxide matrix. Photoconductivity measurements were conducted with exposure of the films to sub-bandgap and super-bandgap light. The results showed a clear photoconductivity effect arising from exposure to super-bandgap light only. These results suggest that the high-efficiency photovoltaic cell structure proposed in DOE sponsored U.S. Patent 5,720,827 is viable. The results of fabrication studies, structural characterization studies and photovoltaic measurements are presented in the report. This report is taken from a PhD dissertation of Tracie J. Bukowski submitted to the University of Florida in May 2002. ''The optical and photoconductive response in germanium quantum dots and indium tin oxide composite thin film structures,'' Dr. Bukowski conducted her PhD study under this grant at the University of Arizona and under Grant No DE-FG05-91ER45462 at the University of Florida, as well as during a two-year fellowship at Sandia National Laboratories.

  10. Multifield Optimization Intensity Modulated Proton Therapy for Head and Neck Tumors: A Translation to Practice

    SciTech Connect (OSTI)

    Frank, Steven J.; Cox, James D.; Gillin, Michael; Mohan, Radhe; Garden, Adam S.; Rosenthal, David I.; Gunn, G. Brandon; Weber, Randal S.; Kies, Merrill S.; Lewin, Jan S.; Munsell, Mark F.; Palmer, Matthew B.; Sahoo, Narayan; Zhang, Xiaodong; Liu, Wei; Zhu, X. Ronald

    2014-07-15

    Background: We report the first clinical experience and toxicity of multifield optimization (MFO) intensity modulated proton therapy (IMPT) for patients with head and neck tumors. Methods and Materials: Fifteen consecutive patients with head and neck cancer underwent MFO-IMPT with active scanning beam proton therapy. Patients with squamous cell carcinoma (SCC) had comprehensive treatment extending from the base of the skull to the clavicle. The doses for chemoradiation therapy and radiation therapy alone were 70 Gy and 66 Gy, respectively. The robustness of each treatment plan was also analyzed to evaluate sensitivity to uncertainties associated with variations in patient setup and the effect of uncertainties with proton beam range in patients. Proton beam energies during treatment ranged from 72.5 to 221.8 MeV. Spot sizes varied depending on the beam energy and depth of the target, and the scanning nozzle delivered the spot scanning treatment “spot by spot” and “layer by layer.” Results: Ten patients presented with SCC and 5 with adenoid cystic carcinoma. All 15 patients were able to complete treatment with MFO-IMPT, with no need for treatment breaks and no hospitalizations. There were no treatment-related deaths, and with a median follow-up time of 28 months (range, 20-35 months), the overall clinical complete response rate was 93.3% (95% confidence interval, 68.1%-99.8%). Xerostomia occurred in all 15 patients as follows: grade 1 in 10 patients, grade 2 in 4 patients, and grade 3 in 1 patient. Mucositis within the planning target volumes was seen during the treatment of all patients: grade 1 in 1 patient, grade 2 in 8 patients, and grade 3 in 6 patients. No patient experienced grade 2 or higher anterior oral mucositis. Conclusions: To our knowledge, this is the first clinical report of MFO-IMPT for head and neck tumors. Early clinical outcomes are encouraging and warrant further investigation of proton therapy in prospective clinical trials.

  11. Effects of Voice Rehabilitation After Radiation Therapy for Laryngeal Cancer: A Randomized Controlled Study

    SciTech Connect (OSTI)

    Tuomi, Lisa; Andrll, Paulin

    2014-08-01

    Background: Patients treated with radiation therapy for laryngeal cancer often experience voice problems. The aim of this randomized controlled trial was to assess the efficacy of voice rehabilitation for laryngeal cancer patients after having undergone radiation therapy and to investigate whether differences between different tumor localizations with regard to rehabilitation outcomes exist. Methods and Materials: Sixty-nine male patients irradiated for laryngeal cancer participated. Voice recordings and self-assessments of communicative dysfunction were performed 1 and 6 months after radiation therapy. Thirty-three patients were randomized to structured voice rehabilitation with a speech-language pathologist and 36 to a control group. Furthermore, comparisons with 23 healthy control individuals were made. Acoustic analyses were performed for all patients, including the healthy control individuals. The Swedish version of the Self Evaluation of Communication Experiences after Laryngeal Cancer and self-ratings of voice function were used to assess vocal and communicative function. Results: The patients who received vocal rehabilitation experienced improved self-rated vocal function after rehabilitation. Patients with supraglottic tumors who received voice rehabilitation had statistically significant improvements in voice quality and self-rated vocal function, whereas the control group did not. Conclusion: Voice rehabilitation for male patients with laryngeal cancer is efficacious regarding patient-reported outcome measurements. The patients experienced better voice function after rehabilitation. Patients with supraglottic tumors also showed an improvement in terms of acoustic voice outcomes. Rehabilitation with a speech-language pathologist is recommended for laryngeal cancer patients after radiation therapy, particularly for patients with supraglottic tumors.

  12. Brachial Plexus-Associated Neuropathy After High-Dose Radiation Therapy for Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Chen, Allen M.; Hall, William H.; Li, Judy; Beckett, Laurel; Farwell, D. Gregory; Lau, Derick H.; Purdy, James A.

    2012-09-01

    Purpose: To identify clinical and treatment-related predictors of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer. Methods and Materials: Three hundred thirty patients who had previously completed radiation therapy for head-and-neck cancer were prospectively screened using a standardized instrument for symptoms of neuropathy thought to be related to brachial plexus injury. All patients were disease-free at the time of screening. The median time from completion of radiation therapy was 56 months (range, 6-135 months). One-hundred fifty-five patients (47%) were treated by definitive radiation therapy, and 175 (53%) were treated postoperatively. Radiation doses ranged from 50 to 74 Gy (median, 66 Gy). Intensity-modulated radiation therapy was used in 62% of cases, and 133 patients (40%) received concurrent chemotherapy. Results: Forty patients (12%) reported neuropathic symptoms, with the most common being ipsilateral pain (50%), numbness/tingling (40%), motor weakness, and/or muscle atrophy (25%). When patients with <5 years of follow-up were excluded, the rate of positive symptoms increased to 22%. On univariate analysis, the following factors were significantly associated with brachial plexus symptoms: prior neck dissection (p = 0.01), concurrent chemotherapy (p = 0.01), and radiation maximum dose (p < 0.001). Cox regression analysis confirmed that both neck dissection (p < 0.001) and radiation maximum dose (p < 0.001) were independently predictive of symptoms. Conclusion: The incidence of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer may be underreported. In view of the dose-response relationship identified, limiting radiation dose to the brachial plexus should be considered when possible.

  13. Voice Quality After Treatment of Early Vocal Cord Cancer: A Randomized Trial Comparing Laser Surgery With Radiation Therapy

    SciTech Connect (OSTI)

    Aaltonen, Leena-Maija; Rautiainen, Noora; Sellman, Jaana; Saarilahti, Kauko; Mkitie, Antti; Rihkanen, Heikki; Laranne, Jussi; Kleemola, Leenamaija; Wigren, Tuija; Sala, Eeva; Lindholm, Paula; Grenman, Reidar; Joensuu, Heikki

    2014-10-01

    Objective: Early laryngeal cancer is usually treated with either transoral laser surgery or radiation therapy. The quality of voice achieved with these treatments has not been compared in a randomized trial. Methods and Materials: Male patients with carcinoma limited to 1 mobile vocal cord (T1aN0M0) were randomly assigned to receive either laser surgery (n=32) or external beam radiation therapy (n=28). Surgery consisted of tumor excision with a CO{sub 2} laser with the patient under general anaesthesia. External beam radiation therapy to the larynx was delivered to a cumulative dose of 66Gy in 2-Gy daily fractions over 6.5weeks. Voice quality was assessed at baseline and 6 and 24months after treatment. The main outcome measures were expert-rated voice quality on a grade, roughness, breathiness, asthenia, and strain (GRBAS) scale, videolaryngostroboscopic findings, and the patients' self-rated voice quality and its impact on activities of daily living. Results: Overall voice quality between the groups was rated similar, but voice was more breathy and the glottal gap was wider in patients treated with laser surgery than in those who received radiation therapy. Patients treated with radiation therapy reported less hoarseness-related inconvenience in daily living 2years after treatment. Three patients in each group had local cancer recurrence within 2years from randomization. Conclusions: Radiation therapy may be the treatment of choice for patients whose requirements for voice quality are demanding. Overall voice quality was similar in both treatment groups, however, indicating a need for careful consideration of patient-related factors in the choice of a treatment option.

  14. Final Report

    SciTech Connect (OSTI)

    Michael C. Weinberg; Lori L. Burgner; Joseph H. Simmons

    2003-05-23

    OAK B135 The formation of metastable crystalline phases in lithium disilicate glass has been a subject of controversy for decades. Here, one aspect of this problem relating to the stability of these non-equilibrium phases when glasses are heated for extended time periods in the nucleation regime is addressed. The results of a systematic experimental investigation on the persistence of metastable phases and the factors that may influence the appearance of such phases, e.g., water content, impurities, glass composition, and glass preparation procedure are presented. Growth rates of lithium disilicate crystals in lithium disilicate glass are measured as a function water concentration in the glass and of temperature in the deeply undercooled regime. The growth rate data obtained in this work are combined with data reported in the literature and used to assess the applicability of standard models of crystal growth for the description of experimental results over a very broad temperature range. The reduced growth rate versus undercooling graph is found to consist of three regimes. For undercoolings less than 140C, the reduced growth rate curve is suggestive of either 2-D surface nucleation or screw dislocation growth. For undercoolings greater than 400C, the reduced growth rate plot suggests the operative crystal growth mechanism is 2-D surface nucleation, but detailed calculations cast doubt upon this conclusion. In the intermediate undercooling range, there appears to be some sort of transitional behavior for which none of the standard models appear to be applicable. Further, it is observed that small differences in the viscosity data employed can produce enormous differences in the predicted growth rates at larger undercoolings. Results of the kinetic analyses conducted herein seem to indicate that the nature of the kinetic rate coefficient used in the standard growth models may be incorrect. Nucleation rates of sodium metasilicate crystals in a sodium silicate glass of composition 43Na2O-57SiO2 (mol%) are investigated using the development technique. The results of this study are compared with the nucleation rate results recently obtained for this composition using a novel DTA method. The two techniques are found to agree within experimental error.

  15. Thiourea derivatives, methods of their preparation and their use in neutron capture therapy of malignant melanoma

    DOE Patents [OSTI]

    Gabel, Detlef

    1991-01-01

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.

  16. Boron containing compounds and their preparation and use in neutron capture therapy

    DOE Patents [OSTI]

    Gabel, Detlef

    1992-01-01

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.

  17. Cold atmospheric plasma in cancer therapy

    SciTech Connect (OSTI)

    Keidar, Michael; Shashurin, Alex; Volotskova, Olga; Ann Stepp, Mary; Srinivasan, Priya; Sandler, Anthony; Trink, Barry

    2013-05-15

    Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 10{sup 8} electrons, the electrical field in the head vicinity is about 10{sup 7} V/m, and the electron density of the streamer column is about 10{sup 19} m{sup ?3}. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.

  18. WIPP AIB Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    WIPP AIB Report WIPP Accident Investigation Board Report Department of Energy (DOE) Issues Accident Investigation Board (AIB) Report on February 14 Incident at the Waste Isolation ...

  19. Annual Coal Distribution Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Annual Coal Distribution Report Release Date: April 16, 2015 | Next Release Date: March 2016 | full report | RevisionCorrection Revision to the Annual Coal Distribution Report ...

  20. Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma

    SciTech Connect (OSTI)

    Xu, Fei; Li, Hongling; Sun, Yong

    2014-11-28

    Highlights: • First reported Axl is co-expressed with ALK in neuroblastoma tissues and cell lines. • Axl activation promotes cell growth and impairs the efficiency of ALK inhibitor. • Further found silence of Axl leads to increased sensitivity to ALK inhibitors. • Axl inhibitor promotes the efficiency of targeted therapy in vitro and in vivo. • Axl activation should be considered in the clinical application of ALK inhibitors. - Abstract: Neuroblastoma (NB) patients harboring mutated ALK can be expected to potentially benefit from targeted therapy based on ALK tyrosine kinase inhibitor (TKI), such as crizotinib and ceritinib. However, the effect of the treatment varies with different individuals, although with the same genic changes. Axl receptor tyrosine kinase is expressed in a variety of human cancers, but little data are reported in NB, particularly in which carrying mutated ALK. In this study, we focus on the roles of Axl in ALK-mutated NB for investigating rational therapeutic strategy. We found that Axl is expressed in ALK-positive NB tissues and cell lines, and could be effectively activated by its ligand GAS6. Ligand-dependent Axl activation obviously rescued crizotinib-mediated suppression of cell proliferation in ALK-mutated NB cells. Genetic inhibition of Axl with specific small interfering RNA markedly increased the sensitivity of cells to ALK-TKIs. Furthermore, a small-molecule inhibitor of Axl significantly enhanced ALK-targeted therapy, as an increased frequency of apoptosis was observed in NB cells co-expressing ALK and Axl. Taken together, our results demonstrated that activation of Axl could lead to insensitivity to ALK inhibitors, and dual inhibition of ALK and Axl might be a potential therapeutic strategy against ALK-mutated NB.

  1. [Purification of {sup 67}Cu]. Progress report

    SciTech Connect (OSTI)

    DeNardo, S.J.

    1994-09-01

    This report documents progress made in several areas of research and describes results which have not yet been published. These areas include: Purification of {sup 67}Cu; Macrocyclic chelates for targeted therapy; Studies of biologic activation associated with molecular receptor increase and tumor response in ChL6/L6 protocol patients; Lym-1 single chain genetically engineered molecules; Analysis of molecular genetic coded messages to enhance tumor response; Human dosimetry and therapeutic human use radiopharmaceuticals; studies in phantoms; Quantitative SPECT; Preclinical studies; and Clinical studies.

  2. Weekly Petroleum Status Report

    Gasoline and Diesel Fuel Update (EIA)

    Please go to the redesigned Weekly Petroleum Status Report.

  3. Health status of young children with cancer following discontinuation of therapy

    SciTech Connect (OSTI)

    Pastore, G.; Zurlo, M.G.; Acquaviva, A.; Calculli, G.; Castello, M.; Ceci, A.; Di Tullio, M.L.; Gandus, S.; Macchia, P.; Di Montezemolo, L.C.

    1987-01-01

    This paper reports late effects and health status of 198 children who had cancer or leukemia diagnosed under 2 years of age and their therapies electively withdrawn. This series (92 neuroblastoma (NBL), 57 Wilms' tumor (WT), 46 acute lymphoblastic leukemia (ALL), and 3 non-Hodgkin's lymphoma) was followed for 1-12 years after discontinuation of therapy. Thirty-three children were diagnosed before 1973, 92 between 1973 and 1977, and 73 after 1977 in 16 Italian Pediatric Oncology Centers. As of December 1983, 176 children were reported to be alive and without evidence of primary cancer by physicians responsible for their care. One child died from a second primary tumor, two from late recurrences of the primary cancer, and three from other causes; eight were alive with evidence of primary cancer; and eight were lost to follow-up. Kyphoscoliosis was found in 22 children and other musculoskeletal anomalies in 8. Neurological sequelae were observed in 8 of 35 children with ALL treated with radiotherapy (RT) and intrathecal methotrexate. All but one were in continuous complete remission when they developed seizures (three cases), leukoencephalopathy (three cases), or intracerebral calcifications (two cases). One child had cardiomyopathy and subsequently died from cardiac failure: he had received doxorubicin (400 mg/m2) and mediastinal RT (13 Gy) for NBL. Growth impairments were observed in children with NBL and WT.

  4. Papers and Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Papers, Reports Papers and Reports Bringing together top space science students with internationally recognized researchers at Los Alamos in an educational and collaborative atmosphere. Contacts Director Misa Cowee Email Administrative Assistant Mary Wubbena Email Request more information Email Annual research reports Report 2015 (pdf - 9.35 MB) Report 2014 (pdf - 12.16 MB) Report 2013 (pdf - 29.06 MB) Report 2012 (pdf - 25.42 MB) Report 2011 (pdf - 10.46 MB) Papers, posters, presentations

  5. Module 8- Reporting

    Broader source: Energy.gov [DOE]

    This module illustrates and defines the different cost performance reports (CPR) available for reporting earned value information.

  6. ARM - Annual Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MaterialsAnnual Reports Publications Journal Articles Conference Documents Program Documents Technical Reports Publications Database Public Information Materials Image Library...

  7. Radiation Therapy for Neovascular Age-related Macular Degeneration

    SciTech Connect (OSTI)

    Kishan, Amar U.; Modjtahedi, Bobeck S.; Morse, Lawrence S.; Lee, Percy

    2013-03-01

    In the enormity of the public health burden imposed by age-related macular degeneration (ARMD), much effort has been directed toward identifying effective and efficient treatments. Currently, anti-vascular endothelial growth factor (VEGF) injections have demonstrated considerably efficacy in treating neovascular ARMD, but patients require frequent treatment to fully benefit. Here, we review the rationale and evidence for radiation therapy of ARMD. The results of early photon external beam radiation therapy are included to provide a framework for the sequential discussion of evidence for the usage of stereotactic radiation therapy, proton therapy, and brachytherapy. The evidence suggests that these 3 modern modalities can provide a dose-dependent benefit in the treatment of ARMD. Most importantly, preliminary data suggest that all 3 can be used in conjunction with anti-VEGF therapeutics, thereby reducing the frequency of anti-VEGF injections required to maintain visual acuity.

  8. Report to Congress on abnormal occurrences, April--June 1989

    SciTech Connect (OSTI)

    Not Available

    1989-10-01

    The Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event which the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to Congress. For this reporting period, there was one abnormal occurrence at nuclear power plants licensed to operate involving significant deficiencies in management controls at Slurry Nuclear Power Station. There was one abnormal occurrence under other NRC-issued licenses; the event involved a medical therapy misadministration. One other abnormal occurrence, involving industrial radiography overexposures, was reported by an Agreement State (Texas). 40 refs.

  9. Modern Radiation Therapy for Extranodal Lymphomas: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group

    SciTech Connect (OSTI)

    Yahalom, Joachim; Illidge, Tim; Specht, Lena; Hoppe, Richard T.; Li, Ye-Xiong; Tsang, Richard; Wirth, Andrew

    2015-05-01

    Extranodal lymphomas (ENLs) comprise about a third of all non-Hodgkin lymphomas (NHL). Radiation therapy (RT) is frequently used as either primary therapy (particularly for indolent ENL), consolidation after systemic therapy, salvage treatment, or palliation. The wide range of presentations of ENL, involving any organ in the body and the spectrum of histological sub-types, poses a challenge both for routine clinical care and for the conduct of prospective and retrospective studies. This has led to uncertainty and lack of consistency in RT approaches between centers and clinicians. Thus far there is a lack of guidelines for the use of RT in the management of ENL. This report presents an effort by the International Lymphoma Radiation Oncology Group (ILROG) to harmonize and standardize the principles of treatment of ENL, and to address the technical challenges of simulation, volume definition and treatment planning for the most frequently involved organs. Specifically, detailed recommendations for RT volumes are provided. We have applied the same modern principles of involved site radiation therapy as previously developed and published as guidelines for Hodgkin lymphoma and nodal NHL. We have adopted RT volume definitions based on the International Commission on Radiation Units and Measurements (ICRU), as has been widely adopted by the field of radiation oncology for solid tumors. Organ-specific recommendations take into account histological subtype, anatomy, the treatment intent, and other treatment modalities that may be have been used before RT.

  10. Assessing the feasibility of volumetric-modulated arc therapy using

    Office of Scientific and Technical Information (OSTI)

    simultaneous integrated boost (SIB-VMAT): An analysis for complex head-neck, high-risk prostate and rectal cancer cases (Journal Article) | SciTech Connect Assessing the feasibility of volumetric-modulated arc therapy using simultaneous integrated boost (SIB-VMAT): An analysis for complex head-neck, high-risk prostate and rectal cancer cases Citation Details In-Document Search Title: Assessing the feasibility of volumetric-modulated arc therapy using simultaneous integrated boost (SIB-VMAT):

  11. Fast Monte Carlo for radiation therapy: the PEREGRINE Project (Conference)

    Office of Scientific and Technical Information (OSTI)

    | SciTech Connect Conference: Fast Monte Carlo for radiation therapy: the PEREGRINE Project Citation Details In-Document Search Title: Fast Monte Carlo for radiation therapy: the PEREGRINE Project × You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and is provided as a public service. Visit OSTI to utilize additional information resources in energy science and technology.

  12. Report to congress on abnormal occurrences: January--March 1992. Volume 15, No. 1

    SciTech Connect (OSTI)

    Not Available

    1992-07-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as abnormal occurrence as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to congress. This report covers the period from January 1 through March 31, 1992. The abnormal occurrences involving medical therapy misadministrations at NRC-licensed facilities are discussed in this report. There were no abnormal occurrences at a nuclear power plant, and none were reported by NRC`s Agreement States. The report also contains information updating some previously reported abnormal occurrences.

  13. Report to Congress on abnormal occurrences, January--March 1989

    SciTech Connect (OSTI)

    Not Available

    1989-08-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event which the Nuclear Regulatory Commission determines to be significant from the standpoint of public health and safety and requires a Quarterly report of such events to be made to Congress. This report covers the period January 1 to March 31, 1989. For this reporting period, there were two abnormal occurrences at nuclear power plants licensed to operate. The first had generic implications and involved a plug failure resulting in a steam generator tube leak at North Anna Unit 1. The second involved a steam generator tube rupture at McGuire Unit 1. There were three abnormal occurrences under other NRC-issued licenses. Two involved medical therapy misadministrations and one involved a medical diagnostic misadministration. There were no abnormal occurrences reported by the Agreement States. The report also contains information updating some previously reported abnormal occurrences.

  14. Report to Congress on abnormal occurrences, October--December 1991. Volume 14, No. 4

    SciTech Connect (OSTI)

    Not Available

    1992-03-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence of an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health and safety and requires a quarterly report of such events to be made to Congress. This report covers the period October through December 1991. Five abnormal occurrences at NRC-licensed facilities are discussed in this report. None of these occurrences involved a nuclear power plant. Four involved medical therapy misadministrations and one involved a medical diagnostic misadministration. The NRC`s Agreement States reported three abnormal occurrences. Two involved exposures of non-radiation workers and one involved a medical therapy misadministration. The report also contains information that updates some previously reported abnormal occurrences.

  15. Annual Site Environmental Report Calendar Year 2010

    SciTech Connect (OSTI)

    Kayser, Dan

    2011-01-31

    This report summarizes the environmental status of Ames Laboratory for calendar year 2010. It includes descriptions of the Laboratory site, its mission, the status of its compliance with applicable environmental regulations, its planning and activities to maintain compliance, and a comprehensive review of its environmental protection, surveillance and monitoring activities. In 2010, the Laboratory accumulated and disposed of waste under U.S. Environmental Protection Agency (EPA) issued generator numbers. All waste is handled according to all applicable EPA, State, Local regulations and DOE Orders. In 2006 the Laboratory reduced its generator status from a Large Quantity Generator (LQG) to a Small Quantity Generator (SQG). EPA Region VII was notified of this change. The Laboratory's RCRA hazardous waste management program was inspected by EPA Region VII in April 2006. There were no notices of violations. The inspector was impressed with the improvements of the Laboratory's waste management program over the past ten years. The Laboratory was in compliance with all applicable federal, state, local and DOE regulations and orders in 2010. There were no radiological air emissions or exposures to the general public due to Laboratory activities in 2010. See U.S. Department of Energy Air Emissions Annual Report in Appendix B. As indicated in prior SERs, pollution awareness, waste minimization and recycling programs have been in practice since 1990, with improvements implemented most recently in 2010. Included in these efforts were battery and CRT recycling, miscellaneous electronic office equipment, waste white paper and green computer paper-recycling and corrugated cardboard recycling. Ames Laboratory also recycles/reuses salvageable metal, used oil, foamed polystyrene peanuts, batteries, fluorescent lamps and telephone books. Ames Laboratory reported to DOE-Ames Site Office (AMSO), through the Laboratory's Performance Evaluation Measurement Plan, on its Affirmative Procurement Performance Measure. A performance level of 'A-' was achieved in 2010 for Integrated Safety, Health and Environmental Protection. As reported in Site Environmental Reports for prior years, the Laboratory's Environmental Management System (EMS) has been integrated into the Laboratory's Integrated Safety Management System since 2005. The integration of EMS into the way the Laboratory does business allows the Laboratory to systematically review, address and respond to the Laboratory's environmental impacts. The Laboratory's EMS was audited in April 2009 by DOE-CH. There were four 'Sufficiently in Conformity' findings as a result of the audit. All four findings were tracked in the Laboratory's corrective action database for completion. Beryllium was used routinely at Ames Laboratory in the 1940's and 1950's in processes developed for the production of highly pure uranium and thorium in support of the historic Manhattan Project. Laboratory metallurgists also worked on a process to produce pure beryllium metal from beryllium fluoride. In the early 1950's, beryllium oxide powder was used to produce shaped beryllium and crucibles. As a result of that work, beryllium contamination now exists in many interstitial spaces (e.g., utility chases) and ventilation systems in Wilhelm, Spedding and Metals Development buildings. Extensive characterization and remediation efforts have occurred in 2009 and 2010 in order to better understand the extent of the contamination. Analysis of extensive sampling data suggests that a fairly wide dispersion of beryllium occurred (most likely in the 1950's and 60's) in Wilhelm Hall and in certain areas of Spedding Hall and Metals Development. Area air-sampling results and work-area surface characterizations indicate the exposure potential to current workers, building visitors and the public remains extremely low. This information is now used to guide cleaning efforts and to provide worker protection during remodeling and maintenance activities. Results were shared with the DOE's Former Worker Program to support former worker medical test

  16. 2012 Hanford Climate Survey Report - ATL Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ATL Report Prepared by EurekaFacts LLC 1 Table of Contents Introduction.................................................................................................................................................... 2 Safety Culture and Climate Focus Areas and Factors .................................................................................. 3 Interpreting the Survey Results Presented in this Report ............................................................................. 4 Key

  17. 2012 Hanford Climate Survey Report - CHPRC Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CHPRC Report Prepared by EurekaFacts LLC 1 Table of Contents Introduction.................................................................................................................................................... 2 Safety Culture and Climate Focus Areas and Factors .................................................................................. 3 Interpreting the Survey Results Presented in this Report ............................................................................. 4 Key

  18. 2012 Hanford Climate Survey Report - MSA Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MSA Report Prepared by EurekaFacts LLC 1 Table of Contents Introduction.................................................................................................................................................... 2 Safety Culture and Climate Focus Areas and Factors .................................................................................. 3 Interpreting the Survey Results Presented in this Report ............................................................................. 4 Key

  19. 2012 Hanford Climate Survey Report - WCH Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    WCH Report Prepared by EurekaFacts LLC 1 Table of Contents Introduction.................................................................................................................................................... 2 Safety Culture and Climate Focus Areas and Factors .................................................................................. 3 Interpreting the Survey Results Presented in this Report ............................................................................. 4 Key

  20. 2012 Hanford Climate Survey Report - WRPS Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    WRPS Report Prepared by EurekaFacts LLC 1 Table of Contents Introduction.................................................................................................................................................... 2 Safety Culture and Climate Focus Areas and Factors .................................................................................. 3 Interpreting the Survey Results Presented in this Report ............................................................................. 4 Key

  1. Reporting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Reporting Reporting Electric Disturbance Events Incident Reporting - OE417 The Electric Emergency Incident and Disturbance Report (Form OE-417) collects information on electric incidents and emergencies. Emergency Situation Reports Reports on energy related activities resulting from natural and man-made disasters. Energy Assurance Daily Energy Assurance Daily provides a summary of public information concerning current energy issues. Transmission Project Reporting - FPA 216h Information on 216(h)

  2. Prospective Study of Local Control and Late Radiation Toxicity After Intraoperative Radiation Therapy Boost for Early Breast Cancer

    SciTech Connect (OSTI)

    Chang, David W.; Marvelde, Luc te; Chua, Boon H.

    2014-01-01

    Purpose: To report the local recurrence rate and late toxicity of intraoperative radiation therapy (IORT) boost to the tumor bed using the Intrabeam System followed by external-beam whole-breast irradiation (WBI) in women with early-stage breast cancer in a prospective single-institution study. Methods and Materials: Women with breast cancer ?3 cm were recruited between February 2003 and May 2005. After breast-conserving surgery, a single dose of 5 Gy IORT boost was delivered using 50-kV x-rays to a depth of 10 mm from the applicator surface. This was followed by WBI to a total dose of 50 Gy in 25 fractions. Patients were reviewed at regular, predefined intervals. Late toxicities were recorded using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer Late Radiation Morbidity Scoring systems. Results: Fifty-five patients completed both IORT boost and external-beam WBI. Median follow-up was 3.3 years (range, 1.4-4.1 years). There was no reported locoregional recurrence or death. One patient developed distant metastases. Grade 2 and 3 subcutaneous fibrosis was detected in 29 (53%) and 8 patients (15%), respectively. Conclusions: The use of IORT as a tumor bed boost using kV x-rays in breast-conserving therapy was associated with good local control but a clinically significant rate of grade 2 and 3 subcutaneous fibrosis.

  3. Quality of Life and Toxicity From Passively Scattered and Spot-Scanning Proton Beam Therapy for Localized Prostate Cancer

    SciTech Connect (OSTI)

    Pugh, Thomas J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek; Nguyen, Quyhn Nhu; Mathai, Benson [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhu, X. Ron; Sahoo, Narayan; Gillin, Michael; Johnson, Jennifer L.; Amos, Richard A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dong, Lei [Scripps Proton Therapy Center, San Diego, California (United States); Mahmood, Usama; Kuban, Deborah A.; Frank, Steven J.; Hoffman, Karen E.; McGuire, Sean E. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lee, Andrew K., E-mail: aklee@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-12-01

    Purpose: To report quality of life (QOL)/toxicity in men treated with proton beam therapy for localized prostate cancer and to compare outcomes between passively scattered proton therapy (PSPT) and spot-scanning proton therapy (SSPT). Methods and Materials: Men with localized prostate cancer enrolled on a prospective QOL protocol with a minimum of 2 years' follow-up were reviewed. Comparative groups were defined by technique (PSPT vs SSPT). Patients completed Expanded Prostate Cancer Index Composite questionnaires at baseline and every 3-6 months after proton beam therapy. Clinically meaningful differences in QOL were defined as ?0.5 baseline standard deviation. The cumulative incidence of modified Radiation Therapy Oncology Group grade ?2 gastrointestinal (GI) or genitourinary (GU) toxicity and argon plasma coagulation were determined by the Kaplan-Meier method. Results: A total of 226 men received PSPT, and 65 received SSPT. Both PSPT and SSPT resulted in statistically significant changes in sexual, urinary, and bowel Expanded Prostate Cancer Index Composite summary scores. Only bowel summary, function, and bother resulted in clinically meaningful decrements beyond treatment completion. The decrement in bowel QOL persisted through 24-month follow-up. Cumulative grade ?2 GU and GI toxicity at 24 months were 13.4% and 9.6%, respectively. There was 1 grade 3 GI toxicity (PSPT group) and no other grade ?3 GI or GU toxicity. Argon plasma coagulation application was infrequent (PSPT 4.4% vs SSPT 1.5%; P=.21). No statistically significant differences were appreciated between PSPT and SSPT regarding toxicity or QOL. Conclusion: Both PSPT and SSPT confer low rates of grade ?2 GI or GU toxicity, with preservation of meaningful sexual and urinary QOL at 24 months. A modest, yet clinically meaningful, decrement in bowel QOL was seen throughout follow-up. No toxicity or QOL differences between PSPT and SSPT were identified. Long-term comparative results in a larger patient cohort are warranted.

  4. Biochemical Response to Androgen Deprivation Therapy Before External Beam Radiation Therapy Predicts Long-term Prostate Cancer Survival Outcomes

    SciTech Connect (OSTI)

    Zelefsky, Michael J.; Gomez, Daniel R.; Polkinghorn, William R.; Pei, Xin; Kollmeier, Marisa

    2013-07-01

    Purpose: To determine whether the response to neoadjuvant androgen deprivation therapy (ADT) defined by a decline in prostate-specific antigen (PSA) to nadir values is associated with improved survival outcomes after external beam radiation therapy (EBRT) for prostate cancer. Methods and Materials: One thousand forty-five patients with localized prostate cancer were treated with definitive EBRT in conjunction with neoadjuvant and concurrent ADT. A 6-month course of ADT was used (3 months during the neoadjuvant phase and 2 to 3 months concurrently with EBRT). The median EBRT prescription dose was 81 Gy using a conformal-based technique. The median follow-up time was 8.5 years. Results: The 10-year PSA relapse-free survival outcome among patients with pre-radiation therapy PSA nadirs of ?0.3 ng/mL was 74.3%, compared with 57.7% for patients with higher PSA nadir values (P<.001). The 10-year distant metastases-free survival outcome among patients with pre-radiation therapy PSA nadirs of ?0.3 ng/mL was 86.1%, compared with 78.6% for patients with higher PSA nadir values (P=.004). In a competing-risk analysis, prostate cancer-related deaths were also significantly reduced among patients with pre-radiation therapy PSA nadirs of <0.3 ng/mL compared with higher values (7.8% compared with 13.7%; P=.009). Multivariable analysis demonstrated that the pre-EBRT PSA nadir value was a significant predictor of long-term biochemical tumor control, distant metastases-free survival, and cause-specific survival outcomes. Conclusions: Pre-radiation therapy nadir PSA values of ?0.3 ng/mL after neoadjuvant ADT were associated with improved long-term biochemical tumor control, reduction in distant metastases, and prostate cancer-related death. Patients with higher nadir values may require alternative adjuvant therapies to improve outcomes.

  5. Monthly Report 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Report 2015 Monthly Report for the Reporting Period ending November 30, 2015, as required by NMED Administrative Orders dated February 27, 2014 and May 12, 2014, as Amended by NMED ...

  6. Report: RFP0001

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 of 5 Report: RFP0001 Fiscal Year: 2010 Fiscal Month: 05 Financial Plan Number: 5 Rpt ... RL14383 - AdvanceMed Hanford Financial Plan Report - Detail Report Generated on: February ...

  7. The Efficacy of Radiation Therapy in the Treatment of Graves' Orbitopathy

    SciTech Connect (OSTI)

    Matthiesen, Chance; Thompson, J. Spencer; Thompson, David; Farris, Bradley; Wilkes, Byron; Ahmad, Salahuddin; Herman, Terence; Bogardus, Carl

    2012-01-01

    Purpose: To review our institutional outcomes of patients treated with radiation therapy (RT) for Graves' orbitopathy (GO), assess the role of orbital reirradiation, and identify prognostic factors of complete response (CR). Methods and Materials: This is a retrospective review of 211 patients who presented with a diagnosis of GO and received RT between January 2000-2010. RT dose was 20 Gy in 10 fractions. Patient median age was 51 years (range, 15-84 years), median follow-up was 11 months (range, 1-88 months). Patient symptoms included any combination of proptosis (90.9%), extraocular muscle dysfunction (78.9%), soft tissue signs (68.4%), and diplopia (58.4%). Corticosteroids were used as first-line therapy in 20.6% of patients. Among those who achieved either CR or partial response (PR), prognostic factors were evaluated. Results: Stabilization of disease without recurrence was clinically achieved overall in 202 patients (96.7%). At the completion of RT, 176 patients (84.2%) reported a symptomatic improvement of pretreatment symptoms. CR of GO symptoms was achieved using multiple treatment modalities, including RT by 93 patients (44.5%), of which 32 patients received RT only. Corticosteroids were discontinued in 97.8% of patients who received them as initial therapy. Surgical intervention following radiotherapy was required for 144 (68.9%) of all patients. Fourteen patients received orbital reirradiation for persistent or recurrent symptoms. Five of these achieved a CR, and the other nine achieved disease stabilization but retained persistent ocular symptoms. Long-term side effects of RT included dry eyes (12%). Of the prognostic factors we investigated, only gender predicted CR, which was less common in men (33.9%) than in women (49.7%) p = 0.0471. Conclusions: Orbital radiation for GO is an established treatment modality for patients. Orbital reirradiation is beneficial for patients who do not respond to initial RT or experience symptom recurrence without an apparent risk of increased morbidity.

  8. 2011 Annual Report.pdf

    Office of Environmental Management (EM)

    transportation shipment accident involving six packages containing radiation therapy sources and a soil moisture density gauge. The scenario required responders to...

  9. Basic Energy Sciences Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Basic Energy Sciences Reports Basic Energy Sciences Reports The list below of Basic Energy Sciences workshop reports addresses the status of some important research areas that can help identify research directions for a decades-to-century energy strategy. Basic Energy Sciences (BES) Workshop Reports The Energy Challenges Report: New Science for a Secure and Sustainable Energy Future This Basic Energy Sciences Advisory Committee (BESAC) report summarizes a 2008 study by the Subcommittee on Facing

  10. Annual Reports - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Annual Reports Soil & Groundwater Home Annual Reports Environmental Data Access Administrative Record Annual Reports Email Email Page | Print Print Page |Text Increase Font Size Decrease Font Size NEW The Groundwater Remediation Project issues an annual report describing its accomplishments and plans. The projects associated with the Groundwater Remediation Project also issue periodic status reports. Those reports can be found in this section. Title Issue Date Rev. Document Information 2014

  11. NERSC Annual Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Annual Reports NERSC Annual Reports Sort by: Default | Name 2014cover.jpg NERSC Annual Report 2014 Download Image: 2014cover.jpg | jpg | 202 KB Download File: 2014NERSCAnnualReport.pdf | pdf | 6.1 MB 2013-Annual-Report-cover.png NERSC Annual Report 2013 Download Image: 2013-Annual-Report-cover.png | png | 645 KB Download File: annrep2013.pdf | pdf | 6.7 MB 2012-Cover.png NERSC Annual Report 2012 Download Image: 2012-Cover.png | png | 420 KB Download File: annrep12.pdf | pdf | 38 MB

  12. Federal Financial Report

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    REPORT (Follow form instructions) 1. Federal Agency and Organizational Element 2. Federal Grant or Other Identifying Number Assigned by Federal Agency Page of to Which Report is ...

  13. PGI Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PGI PGI Bug Reports PGI Bug Reports Internal compiler error for function pointer with identically named arguments June 9, 2015 by Scott French, NERSC USG Status: Bug 21435...

  14. Capital Reporting Company Quadrennial ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    TAKER NATALIE KEMPKEY-NOTE TAKER Capital Reporting Company Quadrennial Energy ... MANAGER-DEVELOPMENT, ACCESS MIDSTREAM Capital Reporting Company Quadrennial Energy ...

  15. Capital Reporting Company Quadrennial ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    CA 94102 REPORTED BY: FREDDIE REPPOND Capital Reporting Company Quadrennial Energy ... Director, Center for Water-Energy 25 Efficiency, University of California at Davis Capital ...

  16. Quarterly Progress Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Quarterly Progress Reports Quarterly Progress Reports Investigating the field of high energy physics through experiments that strengthen our fundamental understanding of matter,...

  17. Uranium Purchases Report

    Reports and Publications (EIA)

    1996-01-01

    Final issue. This report details natural and enriched uranium purchases as reported by owners and operators of commercial nuclear power plants. 1996 represents the most recent publication year.

  18. Papers and Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Papers, Reports Papers and Reports Bringing together top space science students with ... or papers related to your Los Alamos Space Weather Summer School project listed here, ...

  19. WE-D-BRD-01: Innovation in Radiation Therapy Delivery: Advanced Digital Linac Features

    SciTech Connect (OSTI)

    Xing, L; Wong, J; Li, R

    2014-06-15

    Last few years has witnessed significant advances in linac technology and therapeutic dose delivery method. Digital linacs equipped with high dose rate FFF beams have been clinically implemented in a number of hospitals. Gated VMAT is becoming increasingly popular in treating tumors affected by respiratory motion. This session is devoted to update the audience with these technical advances and to present our experience in clinically implementing the new linacs and dose delivery methods. Topics to be covered include, technical features of new generation of linacs from different vendors, dosimetric characteristics and clinical need for FFF-beam based IMRT and VMAT, respiration-gated VMAT, the concept and implementation of station parameter optimized radiation therapy (SPORT), beam level imaging and onboard image guidance tools. Emphasis will be on providing fundamental understanding of the new treatment delivery and image guidance strategies, control systems, and the associated dosimetric characteristics. Commissioning and acceptance experience on these new treatment delivery technologies will be reported. Clinical experience and challenges encountered during the process of implementation of the new treatment techniques and future applications of the systems will also be highlighted. Learning Objectives: Present background knowledge of emerging digital linacs and summarize their key geometric and dosimetric features. SPORT as an emerging radiation therapy modality specifically designed to take advantage of digital linacs. Discuss issues related to the acceptance and commissioning of the digital linacs and FFF beams. Describe clinical utility of the new generation of digital linacs and their future applications.

  20. Microsoft Word - Blue Report Cover Report

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Report on Critical Asset Vulnerability and Risk Assessments at the Power Marketing ... and Risk Assessment at the Power Marketing Administrations--Follow-up Audit" ...

  1. Hanford Lifecycle Reports - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hanford Lifecycle Reports Hanford Lifecycle Reports Hanford Lifecycle Reports Hanford Lifecycle Reports Email Email Page | Print Print Page |Text Increase Font Size Decrease Font Size 2016 Hanford Lifecycle Report 2015 Hanford Lifecycle Report 2014 Hanford Lifecycle Report 2013 Hanford Lifecycle Report 2012 Hanford Lifecycle Report 2011 Hanford Lifecycle Report Share on Last Updated 02/22/2016 2:54

  2. Quarterly Progress Report

    Broader source: Energy.gov [DOE]

    Quarterly Progress Report, from the Tool Kit Framework: Small Town University Energy Program (STEP).

  3. Technical Consultant Report Template

    Office of Energy Efficiency and Renewable Energy (EERE)

    Technical Consultant Report Template, from the Tool Kit Framework: Small Town University Energy Program (STEP).

  4. Daily Occurrence Reports

    Broader source: Energy.gov [DOE]

    DOE posting of occurrence reports will contain reports that were transmitted since the morning of the previous workday. The summary will provide a brief description of each occurrence along with the facility's organizational information and the title of the report. For those that desire additional information, the listing will contain the full occurrence reports.

  5. STEP Program Benchmark Report

    Broader source: Energy.gov [DOE]

    STEP Program Benchmark Report, from the Tool Kit Framework: Small Town University Energy Program (STEP).

  6. STEP Participant Survey Report

    Broader source: Energy.gov [DOE]

    STEP Participant Survey Report, from the Tool Kit Framework: Small Town University Energy Program (STEP).

  7. 2008 Annual Report

    SciTech Connect (OSTI)

    2008-01-01

    This annual report includes: a brief overview of Western; FY 2008 operational highlights; and financial data.

  8. CAF Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reports CAF Bug Reports Viewing entries posted in November 2013 There are currently no significant reported user bugs with CAF. November 18, 2013 No reported CAF bugs. Read the full post Subscribe via RSS Subscribe Browse by Date November 2013 Last edited: 2016-04-29 11:34:54

  9. CAF Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    » CAF Bug Reports CAF Bug Reports There are currently no significant reported user bugs with CAF. November 18, 2013 No reported CAF bugs. Read the full post Subscribe via RSS Subscribe Browse by Date November 2013 Last edited: 2016-04-29 11:34:54

  10. Audit Report: IG-0651

    Office of Energy Efficiency and Renewable Energy (EERE)

    Audit Report on Management of the Department's Personnel Security and Access Control Information Systems

  11. A Dosimetric Comparison of Tomotherapy and Volumetric Modulated Arc Therapy in the Treatment of High-Risk Prostate Cancer With Pelvic Nodal Radiation Therapy

    SciTech Connect (OSTI)

    Pasquier, David; Universite Lille Nord de France, Lille; Centre Galilee, Clinique de la Louviere, Lille ; Cavillon, Fabrice; Faculte Libre de Medecine, Lille ; Lacornerie, Thomas; Universite Lille Nord de France, Lille ; Touzeau, Claire; Tresch, Emmanuelle; Lartigau, Eric; Universite Lille Nord de France, Lille

    2013-02-01

    Purpose: To compare the dosimetric results of volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT) in the treatment of high-risk prostate cancer with pelvic nodal radiation therapy. Methods and Materials: Plans were generated for 10 consecutive patients treated for high-risk prostate cancer with prophylactic whole pelvic radiation therapy (WPRT) using VMAT and HT. After WPRT, a sequential boost was delivered to the prostate. Plan quality was assessed according to the criteria of the International Commission on Radiation Units and Measurements 83 report: the near-minimal (D98%), near-maximal (D2%), and median (D50%) doses; the homogeneity index (HI); and the Dice similarity coefficient (DSC). Beam-on time, integral dose, and several organs at risk (OAR) dosimetric indexes were also compared. Results: For WPRT, HT was able to provide a higher D98% than VMAT (44.3 {+-} 0.3 Gy and 43.9 {+-} 0.5 Gy, respectively; P=.032) and a lower D2% than VMAT (47.3 {+-} 0.3 Gy and 49.1 {+-} 0.7 Gy, respectively; P=.005), leading to a better HI. The DSC was better for WPRT with HT (0.89 {+-} 0.009) than with VMAT (0.80 {+-} 0.02; P=.002). The dosimetric indexes for the prostate boost did not differ significantly. VMAT provided better rectum wall sparing at higher doses (V70, V75, D2%). Conversely, HT provided better bladder wall sparing (V50, V60, V70), except at lower doses (V20). The beam-on times for WPRT and prostate boost were shorter with VMAT than with HT (3.1 {+-} 0.1 vs 7.4 {+-} 0.6 min, respectively; P=.002, and 1.5 {+-} 0.05 vs 3.7 {+-} 0.3 min, respectively; P=.002). The integral dose was slightly lower for VMAT. Conclusion: VMAT and HT provided very similar and highly conformal plans that complied well with OAR dose-volume constraints. Although some dosimetric differences were statistically significant, they remained small. HT provided a more homogeneous dose distribution, whereas VMAT enabled a shorter delivery time.

  12. NERSC Annual Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NERSC Annual Reports NERSC Annual Reports Sort by: Default | Name anrep2000.png NERSC Annual Report 2000 Download Image: anrep2000.png | png | 203 KB Download File: NERSCAnnualReport2000.pdf | pdf | 4.9 MB anrep2001.png NERSC Annual Report 2001 Download Image: anrep2001.png | png | 175 KB Download File: annrep01.pdf | pdf | 7.1 MB anrep2002.png NERSC Annual Report 2002 Download Image: anrep2002.png | png | 55 KB Download File: annrep02.pdf | pdf | 3.4 MB anrep2003.png NERSC Annual Report 2003

  13. Publications & Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    User Surveys HPC Requirements for Science HPC Workshop Reports NERSC Staff Publications & Presentations Journal Cover Stories Galleries facebook icon Facebook google plus icon Google+ twitter icon Twitter Home » News & Publications » Publications & Reports Publications & Reports » Download the NERSC Strategic Plan (PDF | 3.2 MB) NERSC Annual Reports NERSC's annual reports highlight the scientific accomplishments of its users and innovations of its staff. Read More » Science

  14. Drilling Productivity Report

    U.S. Energy Information Administration (EIA) Indexed Site

    Drilling Productivity Report Report Background and Methodological Overview August 2014 Updated March 2016 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 U.S. Energy Information Administration | Drilling Productivity Report: Report Background and Methodological Overview i This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data,

  15. ALS Activity Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Activity Reports Print These hard-copy annual reports were produced from 1993-2006. They illustrated the depth and breadth of the ALS scientific program with a selection of research results. They also summarized operations and ongoing R&D, highlighted educational outreach efforts and special events, and provided yearly documentation of the beamlines and publications. The Activity Report was replaced in 2007 by ALS Spectrum. The reports for 1996-2006 are available here. Activity Report

  16. ALS Activity Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Activity Reports Print These hard-copy annual reports were produced from 1993-2006. They illustrated the depth and breadth of the ALS scientific program with a selection of research results. They also summarized operations and ongoing R&D, highlighted educational outreach efforts and special events, and provided yearly documentation of the beamlines and publications. The Activity Report was replaced in 2007 by ALS Spectrum. The reports for 1996-2006 are available here. Activity Report 2006

  17. ALS Activity Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Activity Reports Print These hard-copy annual reports were produced from 1993-2006. They illustrated the depth and breadth of the ALS scientific program with a selection of research results. They also summarized operations and ongoing R&D, highlighted educational outreach efforts and special events, and provided yearly documentation of the beamlines and publications. The Activity Report was replaced in 2007 by ALS Spectrum. The reports for 1996-2006 are available here. Activity Report 2006

  18. ALS Activity Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Activity Reports Print These hard-copy annual reports were produced from 1993-2006. They illustrated the depth and breadth of the ALS scientific program with a selection of research results. They also summarized operations and ongoing R&D, highlighted educational outreach efforts and special events, and provided yearly documentation of the beamlines and publications. The Activity Report was replaced in 2007 by ALS Spectrum. The reports for 1996-2006 are available here. Activity Report 2006

  19. Annual Site Environmental Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2014 Annual Site Environmental Report Updated July 24, 2015 NETL's Annual Site Environmental Report for 2014 -ii- 2014 Annual Site Environmental Report September 9, 2015 U.S. Department of Energy National Energy Technology Laboratory Albany, Oregon Anchorage, Alaska Morgantown, West Virginia Pittsburgh, Pennsylvania Sugar Land, Texas NETL's Annual Site Environmental Report for 2014 -iii- Disclaimer This report was prepared as an account of work sponsored by an agency of the U.S. Government.

  20. Factors influencing radiation therapy student clinical placement satisfaction

    SciTech Connect (OSTI)

    Bridge, Pete; Carmichael, Mary-Ann

    2014-02-15

    Introduction: Radiation therapy students at Queensland University of Technology (QUT) attend clinical placements at five different clinical departments with varying resources and support strategies. This study aimed to determine the relative availability and perceived importance of different factors affecting student support while on clinical placement. The purpose of the research was to inform development of future support mechanisms to enhance radiation therapy students experience on clinical placement. Methods: This study used anonymous Likert-style surveys to gather data from years 1 and 2 radiation therapy students from QUT and clinical educators from Queensland relating to availability and importance of support mechanisms during clinical placements in a semester. Results: The study findings demonstrated student satisfaction with clinical support and suggested that level of support on placement influenced student employment choices. Staff support was perceived as more important than physical resources; particularly access to a named mentor, a clinical educator and weekly formative feedback. Both students and educators highlighted the impact of time pressures. Conclusions: The support offered to radiation therapy students by clinical staff is more highly valued than physical resources or models of placement support. Protected time and acknowledgement of the importance of clinical education roles are both invaluable. Joint investment in mentor support by both universities and clinical departments is crucial for facilitation of effective clinical learning.

  1. Proceedings of the first international symposium on neutron capture therapy

    SciTech Connect (OSTI)

    Fairchild, R.G.; Brownell, G.L.

    1982-01-01

    This meeting was arranged jointly by MIT and BNL in order to illuminate progress in the synthesis and targeting of boron compounds and to evaluate and document progress in radiobiological and dosimetric aspects of neutron capture therapy. It is hoped that this meeting will facilitate transfer of information between groups working in these fields, and encourage synergistic collaboration.

  2. Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer

    SciTech Connect (OSTI)

    Wang, Jingya [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Tucker, Susan L. [Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan; Palmer, Matthew [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hofstetter, Wayne L.; Swisher, Stephen G. [Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D.; Komaki, Ritsuko; Liao, Zhongxing [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lin, Steven H., E-mail: SHLin@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-08-01

    Purpose: While trimodality therapy for esophageal cancer has improved patient outcomes, surgical complication rates remain high. The goal of this study was to identify modifiable factors associated with postoperative complications after neoadjuvant chemoradiation. Methods and Materials: From 1998 to 2011, 444 patients were treated at our institution with surgical resection after chemoradiation. Postoperative (pulmonary, gastrointestinal [GI], cardiac, wound healing) complications were recorded up to 30 days postoperatively. Kruskal-Wallis tests and ?{sup 2} or Fisher exact tests were used to assess associations between continuous and categorical variables. Multivariate logistic regression tested the association between perioperative complications and patient or treatment factors that were significant on univariate analysis. Results: The most frequent postoperative complications after trimodality therapy were pulmonary (25%) and GI (23%). Lung capacity and the type of radiation modality used were independent predictors of pulmonary and GI complications. After adjusting for confounding factors, pulmonary and GI complications were increased in patients treated with 3-dimensional conformal radiation therapy (3D-CRT) versus intensity modulated radiation therapy (IMRT; odds ratio [OR], 2.018; 95% confidence interval [CI], 1.104-3.688; OR, 1.704; 95% CI, 1.03-2.82, respectively) and for patients treated with 3D-CRT versus proton beam therapy (PBT; OR, 3.154; 95% CI, 1.365-7.289; OR, 1.55; 95% CI, 0.78-3.08, respectively). Mean lung radiation dose (MLD) was strongly associated with pulmonary complications, and the differences in toxicities seen for the radiation modalities could be fully accounted for by the MLD delivered by each of the modalities. Conclusions: The radiation modality used can be a strong mitigating factor of postoperative complications after neoadjuvant chemoradiation.

  3. June 2015 Most Viewed Documents for Biology And Medicine | OSTI, US Dept of

    Office of Scientific and Technical Information (OSTI)

    Energy, Office of Scientific and Technical Information June 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 115 Dose and volume specification for reporting interstitial therapy

  4. March 2014 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy, Office of Scientific and Technical Information 4 Most Viewed Documents for Biology And Medicine Science Subject Feed Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 30 /> Dose and volume specification for reporting interstitial therapy NONE (1997) 29 /> Geothermal demonstration: Zunil food dehydration facility Maldonado, O. (Consultecnia, Guatemala City (Guatemala)); Altseimer, J.; Thayer, G.R. (Los

  5. Most Viewed Documents for Biology and Medicine: December 2014 | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy, Office of Scientific and Technical Information Most Viewed Documents for Biology and Medicine: December 2014 Dose and volume specification for reporting interstitial therapy NONE (1997) 38 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 38 Drug Retention Times Center for Human Reliability Studies (2007) 34 Degradation of high concentrations of

  6. Most Viewed Documents for Biology and Medicine: September 2014 | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy, Office of Scientific and Technical Information for Biology and Medicine: September 2014 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 32 Dose and volume specification for reporting interstitial therapy NONE (1997) 28 Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 27 Drug

  7. Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

    SciTech Connect (OSTI)

    Woodward, Wendy A. Bristow, Robert G.; Clarke, Michael F.; Coppes, Robert P.; Cristofanilli, Massimo; Duda, Dan G.; Fike, John R.; Hambardzumyan, Dolores; Hill, Richard P.; Jordan, Craig T.; Milas, Luka; Pajonk, Frank; Curran, Walter J.; Dicker, Adam P.; Chen Yuhchyau

    2009-08-01

    At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.

  8. Annual Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Annual Reports Annual Reports Note: Some of the following documents are in PDF and will require Adobe Reader for viewing. Freedom of Information Act Annual Reports Annual Report for 2015 Annual Report for 2014 Annual Report for 2013 Annual Report for 2012 Annual Report for 2011 Annual Report for 2010 Annual Report for 2009 Annual Report for 2008 (pdf) Annual Report for 2007 (pdf) Annual Report for 2006 (pdf) Annual Report for 2005 (pdf) Annual Report for 2004 (pdf) Annual Report for 2003 (pdf)

  9. Definitive Chemoradiation Therapy Following Surgical Resection or Radiosurgery Plus Whole-Brain Radiation Therapy in Non-Small Cell Lung Cancer Patients With Synchronous Solitary Brain Metastasis: A Curative Approach

    SciTech Connect (OSTI)

    Parlak, Cem; Mertsoylu, Hüseyin; Güler, Ozan Cem; Onal, Cem; Topkan, Erkan

    2014-03-15

    Purpose/Objectives: The aim of this study was to evaluate the impact of definitive thoracic chemoradiation therapy following surgery or stereotactic radiosurgery (SRS) and whole-brain radiation therapy (WBRT) on the outcomes of patients with non-small cell lung cancer (NSCLC) with synchronous solitary brain metastasis (SSBM). Methods and Materials: A total of 63 NSCLC patients with SSBM were retrospectively evaluated. Patients were staged using positron emission tomography-computed tomography in addition to conventional staging tools. Thoracic radiation therapy (TRT) with a total dose of 66 Gy in 2 Gy fractions was delivered along with 2 cycles of cisplatin-based chemotherapy following either surgery plus 30 Gy of WBRT (n=33) or SRS plus 30 Gy of WBRT (n=30) for BM. Results: Overall, the treatment was well tolerated. All patients received planned TRT, and 57 patients (90.5%) were also able to receive 2 cycles of chemotherapy. At a median follow-up of 25.3 months (7.1-52.1 months), the median months of overall, locoregional progression-free, neurological progression-free, and progression-free survival were 28.6, 17.7, 26.4, and 14.6, respectively. Both univariate and multivariate analyses revealed that patients with a T1-T2 thoracic disease burden (P=.001), a nodal stage of N0-N1 (P=.003), and no weight loss (P=.008) exhibited superior survival. Conclusions: In the present series, surgical and radiosurgical treatments directed toward SSBM in NSCLC patients were equally effective. The similarities between the present survival outcomes and those reported in other studies for locally advanced NSCLC patients indicate the potentially curative role of definitive chemoradiation therapy for highly selected patients with SSBM.

  10. Thiourea derivatives, methods of their preparation and their use in neutron capture therapy of malignant melanoma

    DOE Patents [OSTI]

    Gabel, D.

    1991-06-04

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy. No Drawings

  11. Boron containing compounds and their preparation and use in neutron capture therapy

    DOE Patents [OSTI]

    Gabel, D.

    1992-09-01

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy. No Drawings

  12. Data Network Weather Service Reporting - Final Report

    SciTech Connect (OSTI)

    Michael Frey

    2012-08-30

    A final report is made of a three-year effort to develop a new forecasting paradigm for computer network performance. This effort was made in co-ordination with Fermi Lab's construction of e-Weather Center.

  13. "Annual Coal Report

    U.S. Energy Information Administration (EIA) Indexed Site

    Annual Coal Report Data Released: January 20, 2015 Data for: 2013 Re-Release Date: April 23, 2015 (CORRECTION) Annual Coal Report 2013 CorrectionUpdate April 23, 2015 The Annual ...

  14. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Report January 2010 F.A. Figueroa President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report January 2010 DOE...

  15. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Report December 2009 F.A. Figueroa President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report December 2009 DOE...

  16. Quarterly Progress Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Effective Recovery of Low-TDS Frac Flowback Water for Re-use Department of Energy: DE-FE0000784 Final Report Reporting Period: October 1, 2009 - March 31, 2011 Harish R. Acharya...

  17. FY 2007 Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2007 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These reports cover the completed activities for the current month and the expectations for the following month. Should you have questions about the EM Monthly Reports please contact envmgt@nv.doe.gov or call (702) 295-3521. October 2006 November 2006 December 2006 January 2007 February 2007 March 2007 April 2007 May 2007 June

  18. FY 2008 Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2008 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These reports cover the completed activities for the current month and the expectations for the following month. Should you have questions about the EM Monthly Reports please contact envmgt@nv.doe.gov or call (702) 295-3521. October 2007 November 2007 December 2007 January 2008 February 2008 March 2008 April 2008 May 2008 June

  19. FY 2009 Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2009 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These reports cover the completed activities for the current month and the expectations for the following month. Should you have questions about the EM Monthly Reports please contact envmgt@nv.doe.gov or call (702) 295-3521. October 2008 November 2008 December 2008 January 2009 February 2009 March 2009 April 2009 May 2009 June

  20. FY 2010 Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2010 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These reports cover the completed activities for the current month and the expectations for the following month. Should you have questions about the EM Monthly Reports please contact envmgt@nv.doe.gov or call (702) 295-3521. October 2009 November 2009 December 2009 January 2010 February 2010 March 2010 April 2010 May 2010 June

  1. FY 2011 Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2011 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These reports cover the completed activities for the current month and the expectations for the following month. Should you have questions about the EM Monthly Reports please contact envmgt@nv.doe.gov or call (702) 295-3521. October 2010 November 2010 December 2010 January 2011 February 2011 March 2011 April 2011 May 2011 June

  2. Guidance, Reports, and Documents

    Broader source: Energy.gov [DOE]

    The following are annual reports, guidance documents, and regulatory drivers for long-term surveillance and maintenance activities.

  3. Annual Site Environmental Report

    Energy Savers [EERE]

    Department of Energy Annual Reports to Congress on Federal Government Energy Management Annual Reports to Congress on Federal Government Energy Management Annual reports on federal energy management respond to section 548 of the National Energy Conservation Policy Act (NECPA, Pub. L. No. 95-619), as amended, and provide information on energy consumption in federal buildings, operations, and vehicles. Compiled by the Federal Energy Management Program, these reports document activities

  4. CM modeling report

    SciTech Connect (OSTI)

    Vann, J.M., Fluor Daniel Hanford

    1997-02-07

    This report compiles TWRS configuration management pre- implementation assessments, categorizes findings, and highlights programs identified for improvement.

  5. Regional Efficiency Progress Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Expand Utility Resources News & Events Expand News & Events Skip navigation links Marketing Resources Reports, Publications, and Research Agricultural Commercial Consumer...

  6. Assorted Situation Reports

    Broader source: Energy.gov [DOE]

    The Office of Electricity Delivery and Energy Reliability issues public Situation Reports during large scale energy emergencies.

  7. MMCR Calibration Report

    SciTech Connect (OSTI)

    Mead, D

    2010-03-23

    Calibration report for the Millimeter Wavelength Cloud Radar performed for the ARM Climate Research Facility by ProSensing Inc.

  8. Federal Financial Report

    Broader source: Energy.gov [DOE]

    Federal Financial Report, as posted on the U.S. Department of Energy's Better Buildings Neighborhood Program website.

  9. Technical Review Panel Report

    Energy Savers [EERE]

    TRP Report v7, 12 Aug 2012 TRP Report Final December 2012 Advanced Reactor Concepts Technical Review Panel Report Evaluation and Identification of future R&D on eight Advanced Reactor Concepts, conducted April - September 2012 December 2012 Public release version 2 Public release version 3 Table of Contents Summary ................................................................................................................................... 4 1. Overview of the Technical Review Panel

  10. Organic solvent topical report

    SciTech Connect (OSTI)

    Cowley, W.L.

    1998-04-30

    This report is the technical basis for the accident and consequence analyses used in the Hanford Tank Farms Basis for Interim Operation. The report also contains the scientific and engineering information and reference material needed to understand the organic solvent safety issue. This report includes comments received from the Chemical Reactions Subcommittee of the Tank Advisory Panel.

  11. 2014 Site Environmental Report

    SciTech Connect (OSTI)

    Paquette, Douglas; Remien, Jason; Foley, Brian; Burke, John; Dorsch, William; Ratel, Karen; Howe, Robert; Welty, Tim; Williams, Jeffrey; Pohlpt, Peter; Lagattolla, Richard; Metz, Robert; Milligan, James; Lettieri, Lawrence

    2015-10-01

    BNL prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1B, Environment, Safety and Health Reporting. The report is written to inform the public, regulators, employees, and other stakeholders of the Laboratory’s environmental performance during the calendar year in review.

  12. Cray Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cray » Cray Bug Reports Cray Bug Reports Cray C/C++ predefined _RELEASE macro returns wrong value [updated] November 18, 2013 by Mike Stewart, NERSC USG Status: Reported to Cray as bug 797442, became documentation bug 805340. Read the full post Subscribe via RSS Subscribe Browse by Date November 2013 Last edited: 2016-04-29 11:34:26

  13. Proposals and Design Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Proposals and Design Reports Proposals and Design Reports Proposal (1/2/04) Proposal Addendum (29/3/04) Physics Case and Detector Technology Report (12/04) Technical Design Report (7/06) Reviews DOE CD-4 DOE 2008 DOE CD-3b CD-3b Readiness DOE CD-1/2/3a CD-2/3a Readiness CD-1 Readiness PAC Report (4/05) Approvals FNAL PAC Approval: April 15, 2004 DOE Critical Decision 1,2,3a (Performance Baseline, Construction Start) Approval: March 30, 2007 DOE Critical Decision 4 (Project Completion) Approval:

  14. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    1997-03-18

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  15. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    1997-08-05

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  16. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    1995-10-03

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  17. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1997-03-18

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  18. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1997-08-05

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  19. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1995-10-03

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  20. Nanoscience and Nanotechnology: From Energy Applications to Advanced Medical Therapies

    ScienceCinema (OSTI)

    Tijana Rajh

    2010-01-08

    Dr. Rajh will present a general talk on nanotechnology ? an overview of why nanotechnology is important and how it is useful in various fields. The specific focus will be on Solar energy conversion, environmental applications and advanced medical therapies. She has broad expertise in synthesis and characterization of nanomaterials that are used in nanotechnology including novel hybrid systems connecting semiconductors to biological molecules like DNA and antibodies. This technology could lead to new gene therapy procedures, cancer treatments and other medical applications. She will also discuss technologies made possible by organizing small semiconductor particles called quantum dots, materials that exhibit a rich variety of phenomena that are size and shape dependent. Development of these new materials that harnesses the unique properties of materials at the 1-100 nanometer scale resulted in the new field of nanotechnology that currently affects many applications in technological and medical fields.

  1. Report number codes

    SciTech Connect (OSTI)

    Nelson, R.N.

    1985-05-01

    This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name.

  2. 2014 Better Buildings Neighborhood Program Reporting Calendar

    Broader source: Energy.gov [DOE]

    Better Buildings Neighborhood Program, reporting, grants, quarterly report, recovery act report, davis-bacon report, historic preservation report, pmc

  3. Dynamic materials testing and constitutive modeling of structural sheet steel for automotive applications. Final progress report

    SciTech Connect (OSTI)

    Cady, C.M.; Chen, S.R.; Gray, G.T. III

    1996-08-23

    The objective of this study was to characterize the dynamic mechanical properties of four different structural sheet steels used in automobile manufacture. The analysis of a drawing quality, special killed (DQSK) mild steel; high strength, low alloy (HSLA) steel; interstitial free (IF); and a high strength steel (M-190) have been completed. In addition to the true stress-true strain data, coefficients for the Johnson-Cook, Zerilli-Armstrong, and Mechanical Threshold Stress constitutive models have been determined from the mechanical test results at various strain rates and temperatures and are summarized. Compression, tensile, and biaxial bulge tests and low (below 0.1/s) strain rate tests were completed for all four steels. From these test results it was determined to proceed with the material modeling optimization using the through thickness compression results. Compression tests at higher strain rates and temperatures were also conducted and analyzed for all the steels. Constitutive model fits were generated from the experimental data. This report provides a compilation of information generated from mechanical tests, the fitting parameters for each of the constitutive models, and an index and description of data files.

  4. Accelerated Partial Breast Irradiation Using Only Intraoperative Electron Radiation Therapy in Early Stage Breast Cancer

    SciTech Connect (OSTI)

    Maluta, Sergio; Dall'Oglio, Stefano; Marciai, Nadia; Gabbani, Milena; Franchini, Zeno; Pietrarota, Paolo; Meliado, Gabriele; Guariglia, Stefania; Cavedon, Carlo

    2012-10-01

    Background: We report the results of a single-institution, phase II trial of accelerated partial breast irradiation (APBI) using a single dose of intraoperative electron radiation therapy (IOERT) in patients with low-risk early stage breast cancer. Methods and Materials: A cohort of 226 patients with low-risk, early stage breast cancer were treated with local excision and axillary management (sentinel node biopsy with or without axillary node dissection). After the surgeon temporarily reapproximated the excision cavity, a dose of 21 Gy using IOERT was delivered to the tumor bed, with a margin of 2 cm laterally. Results: With a mean follow-up of 46 months (range, 28-63 months), only 1 case of local recurrence was reported. The observed toxicity was considered acceptable. Conclusions: APBI using a single dose of IOERT can be delivered safely in women with early, low-risk breast cancer in carefully selected patients. A longer follow-up is needed to ascertain its efficacy compared to that of the current standard treatment of whole-breast irradiation.

  5. Malfunctions of Implantable Cardiac Devices in Patients Receiving Proton Beam Therapy: Incidence and Predictors

    SciTech Connect (OSTI)

    Gomez, Daniel R., E-mail: dgomez@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Poenisch, Falk [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Pinnix, Chelsea C. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Sheu, Tommy [Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Joe Y. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Memon, Nada [Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Rozner, Marc A. [Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dougherty, Anne H. [Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-11-01

    Purpose: Photon therapy has been reported to induce resets of implanted cardiac devices, but the clinical sequelae of treating patients with such devices with proton beam therapy (PBT) are not well known. We reviewed the incidence of device malfunctions among patients undergoing PBT. Methods and Materials: From March 2009 through July 2012, 42 patients with implanted cardiac implantable electronic devices (CIED; 28 pacemakers and 14 cardioverter-defibrillators) underwent 42 courses of PBT for thoracic (23, 55%), prostate (15, 36%), liver (3, 7%), or base of skull (1, 2%) tumors at a single institution. The median prescribed dose was 74 Gy (relative biological effectiveness; range 46.8-87.5 Gy), and the median distance from the treatment field to the CIED was 10 cm (range 0.8-40 cm). Maximum proton and neutron doses were estimated for each treatment course. All CIEDs were checked before radiation delivery and monitored throughout treatment. Results: Median estimated peak proton and neutron doses to the CIED in all patients were 0.8 Gy (range 0.13-21 Gy) and 346 Sv (range 11-1100 mSv). Six CIED malfunctions occurred in 5 patients (2 pacemakers and 3 defibrillators). Five of these malfunctions were CIED resets, and 1 patient with a defibrillator (in a patient with a liver tumor) had an elective replacement indicator after therapy that was not influenced by radiation. The mean distance from the proton beam to the CIED among devices that reset was 7.0 cm (range 0.9-8 cm), and the mean maximum neutron dose was 655 mSv (range 330-1100 mSv). All resets occurred in patients receiving thoracic PBT and were corrected without clinical incident. The generator for the defibrillator with the elective replacement indicator message was replaced uneventfully after treatment. Conclusions: The incidence of CIED resets was about 20% among patients receiving PBT to the thorax. We recommend that PBT be avoided in pacing-dependent patients and that patients with any type of CIED receiving thoracic PBT be followed closely.

  6. Replanning During Intensity Modulated Radiation Therapy Improved Quality of Life in Patients With Nasopharyngeal Carcinoma

    SciTech Connect (OSTI)

    Yang Haihua; Hu Wei; Wang Wei; Chen Peifang; Ding Weijun; Luo Wei

    2013-01-01

    Purpose: Anatomic and dosimetric changes have been reported during intensity modulated radiation therapy (IMRT) in patients with nasopharyngeal carcinoma (NPC). The purpose of this study was to evaluate the effects of replanning on quality of life (QoL) and clinical outcomes during the course of IMRT for NPC patients. Methods and Materials: Between June 2007 and August 2011, 129 patients with NPC were enrolled. Forty-three patients received IMRT without replanning, while 86 patients received IMRT replanning after computed tomography (CT) images were retaken part way through therapy. Chinese versions of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 and Head and Neck Quality of Life Questionnaire 35 were completed before treatment began and at the end of treatment and at 1, 3, 6, and 12 months after the completion of treatment. Overall survival (OS) data were compared using the Kaplan-Meier method. Results: IMRT replanning had a profound impact on the QoL of NPC patients, as determined by statistically significant changes in global QoL and other QoL scales. Additionally, the clinical outcome comparison indicates that replanning during IMRT for NPC significantly improved 2-year local regional control (97.2% vs 92.4%, respectively, P=.040) but did not improve 2-year OS (89.8% vs 82.2%, respectively, P=.475). Conclusions: IMRT replanning improves QoL as well as local regional control in patients with NPC. Future research is needed to determine the criteria for replanning for NPC patients undergoing IMRT.

  7. Monte Carlo and analytical model predictions of leakage neutron exposures from passively scattered proton therapy

    SciTech Connect (OSTI)

    Prez-Andjar, Anglica [Department of Radiation Physics, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 (United States)] [Department of Radiation Physics, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 (United States); Zhang, Rui; Newhauser, Wayne [Department of Radiation Physics, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, 6767 Bertner Avenue, Houston, Texas 77030 (United States)] [Department of Radiation Physics, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, 6767 Bertner Avenue, Houston, Texas 77030 (United States)

    2013-12-15

    Purpose: Stray neutron radiation is of concern after radiation therapy, especially in children, because of the high risk it might carry for secondary cancers. Several previous studies predicted the stray neutron exposure from proton therapy, mostly using Monte Carlo simulations. Promising attempts to develop analytical models have also been reported, but these were limited to only a few proton beam energies. The purpose of this study was to develop an analytical model to predict leakage neutron equivalent dose from passively scattered proton beams in the 100-250-MeV interval.Methods: To develop and validate the analytical model, the authors used values of equivalent dose per therapeutic absorbed dose (H/D) predicted with Monte Carlo simulations. The authors also characterized the behavior of the mean neutron radiation-weighting factor, w{sub R}, as a function of depth in a water phantom and distance from the beam central axis.Results: The simulated and analytical predictions agreed well. On average, the percentage difference between the analytical model and the Monte Carlo simulations was 10% for the energies and positions studied. The authors found that w{sub R} was highest at the shallowest depth and decreased with depth until around 10 cm, where it started to increase slowly with depth. This was consistent among all energies.Conclusion: Simple analytical methods are promising alternatives to complex and slow Monte Carlo simulations to predict H/D values. The authors' results also provide improved understanding of the behavior of w{sub R} which strongly depends on depth, but is nearly independent of lateral distance from the beam central axis.

  8. Damaged Surface Hydrodynamics (DSH) Flash Report (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Damaged Surface Hydrodynamics (DSH) Flash Report Citation Details In-Document Search Title: Damaged Surface Hydrodynamics (DSH) Flash Report You are accessing ...

  9. FY09 Engineering Research & Technology Report (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: FY09 Engineering Research & Technology Report Citation Details In-Document Search Title: FY09 Engineering Research & Technology Report Authors: Sharpe, R ; Pannu, ...

  10. 2006 SITE ENVIRONMENTAL REPORT

    SciTech Connect (OSTI)

    BROOKHAVEN NATIONAL LABORATORY; RATEL,K.

    2007-10-01

    Each year, Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy. The report is written to inform the public, regulators, employees, and other stakeholders of BNL's environmental performance during the calendar year in review. The SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and compliance, restoration, and surveillance monitoring program performance. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. The report is available in print and as a downloadable file on the BNL web page at http://www.bnl.gov/ewms/ser/. A summary of the SER is also prepared each year to provide a general overview of the report, and is distributed with a CD of the full report.

  11. 2005 SITE ENVIRONMENTAL REPORT

    SciTech Connect (OSTI)

    BROOKHAVEN NATIONAL LABORATORY

    2006-08-29

    Each year, Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy (DOE). The report is written to inform the public, regulators, employees, and other stakeholders of BNL's environmental performance during the calendar year in review. The SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and compliance, restoration, and surveillance monitoring program performance. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. The report is available in print and as a downloadable file on the BNL web page at http://www.bnl.gov/ewms/ser/. A summary of the SER is also prepared each year to provide a general overview of the report, and is distributed with a CD of the full report.

  12. LANSCE Activity Report

    SciTech Connect (OSTI)

    Amy Robinson; Audrey Archuleta; Barbara Maes; Dan Strottman; Earl Hoffman; Garth Tietjen; Gene Farnum; Geoff Greene; Joyce Roberts; Ken Johnson; Paul Lewis; Roger Pynn; Stan Schriber; Steve Sterbenz; Steve Wender; Sue Harper

    1999-02-01

    The Los Alamos Neutron Science Center Activity Report describes scientific and technological progress and achievements in LANSCE Division during the period of 1995 to 1998. This report includes a message from the Division Director, an overview of LANSCE, sponsor overviews, research highlights, advanced projects and facility upgrades achievements, experimental and user program accomplishments, news and events, and a list of publications. The research highlights cover the areas of condensed-matter science and engineering, accelerator science, nuclear science, and radiography. This report also contains a compact disk that includes an overview, the Activity Report itself, LANSCE operations progress reports for 1996 and 1997, experiment reports from LANSCE users, as well as a search capability.

  13. 2009 Site Environmental Report

    SciTech Connect (OSTI)

    Ratel, K.M.; Brookhaven National Laboratory

    2010-09-30

    Each year, Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy. The report is written to inform the public, regulators, employees, and other stakeholders of BNL's environmental performance during the calendar year in review. The SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and compliance, restoration, and surveillance monitoring program performance. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. The report is available in print and as a downloadable file on the BNL web page at http://www.bnl.gov/ewms/ser/. A summary of the SER is also prepared each year to provide a general overview of the report, and is distributed with a CD of the full report.

  14. UPC Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    » UPC Bug Reports UPC Bug Reports Deadlock during first touch of upc_alloc'd remote memory when target is in upc_barrier [updated] October 16, 2014 Status: This has been reported to Cray (811537) and a workaround is available. Fixed in CCE 8.3.5. Read the full post Subscribe via RSS Subscribe Browse by Date October 2014 Last edited: 2016-04-29 11:34:42

  15. Section 1251 Report Update

    National Nuclear Security Administration (NNSA)

    November 2010 Update to the National Defense Authorization Act of FY2010 Section 1251 Report New START Treaty Framework and Nuclear Force Structure Plans 1. Introduction This paper updates elements of the report that was submitted to Congress on May 13, 2010, pursuant to section 1251 of the National Defense Authorization Act for Fiscal Year 2010 (Public Law 111-84) ("1251 Report"). 2. National Nuclear Security Administration and modernization of the complex - an overview From FY 2005

  16. FY 2009 Summary Report

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Performance and financial information FY 2009 DOE/CF-0045 The Reports Consolidation Act of 2000 authorizes Federal agencies, with the Office of Management and Budget's (OMB) concurrence, to consolidate various reports in order to provide performance, financial and related information in a more meaningful and useful format. In accordance with the Act, the Department of Energy (Department or DOE), has produced a consolidated Performance and Accountability Report (PAR) in previous years. For

  17. DOE WEEKLY REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    January 30, 2009 The following program offices did not submit a Weekly Report for this time period: All Program Offices Reported BONNEVILLE POWER ADMINISTRATION WEEKLY REPORT January 30, 2009 Schedule February 2 - 5: The Bonneville Power Administration (BPA) Administrator Steve Wright will be in Washington, D.C., to meet with members of the Pacific Northwest congressional delegation and Department of Energy officials. Deputy . . iiuuiJli atut JteVc u ■, acting. February 12: The Administrator

  18. Monthly Biodiesel Production Report

    U.S. Energy Information Administration (EIA) Indexed Site

    Monthly Biodiesel Production Report With data for February 2016 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 April 2016 U.S. Energy Information Administration | Monthly Biodiesel Production Report This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data, analyses, and forecasts are independent of approval by any other officer or

  19. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Monthly Performance Report September 2015 W. K. Johnson President U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report SEP 2015 DOE/RL-2009-113 Rev 72 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report SEP 2015 DOE/RL-2009-113 Rev 72 iii CONTENTS EXECUTIVE OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  20. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 Monthly Performance Report January 2016 W. K. Johnson President U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report JAN 2016 DOE/RL-2009-113 Rev 76 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report JAN 2016 DOE/RL-2009-113 Rev 76 iii CONTENTS EXECUTIVE OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  1. Requirements Review Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Requirements Review Reports Case Studies News & Publications ESnet News Publications and Presentations Galleries ESnet Awards and Honors Blog ESnet Live Home » Science Engagement » Science Requirements Reviews » Requirements Review Reports Science Engagement Move your data Programs & Workshops Science Requirements Reviews Network Requirements Reviews Requirements Review Reports Case Studies Contact Us Technical Assistance: 1 800-33-ESnet (Inside US) 1 800-333-7638 (Inside US) 1

  2. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7 Monthly Performance Report August 2013 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report AUG 2013 DOE/RL-2009-113 Rev 47 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report AUG 2013 DOE/RL-2009-113 Rev 47 iii CONTENTS EXECUTIVE OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  3. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5 Monthly Performance Report February 2010 F.A. Figueroa President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report February 2010 DOE/RL-2009-113 REV 5 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report February 2010 DOE/RL-2009-113 REV 5 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key

  4. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Monthly Performance Report November 2009 F.A. Figueroa President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report November 2009 DOE/RL-2009-113 REV 2 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report November 2009 DOE/RL-2009-113 REV 2 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key

  5. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 Monthly Performance Report May 2010 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report May 2010 DOE/RL-2009-113 REV 8 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report May 2010 DOE/RL-2009-113 REV 8 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  6. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Monthly Performance Report July 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report July 2011 DOE/RL-2009-113 REV 22 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report July 2011 DOE/RL-2009-113 REV 22 iii CONTENTS OVERVIEW 1.0 INTRODUCTION ......................................................................................................................... 1 1.1 Key Accomplishments

  7. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 Monthly Performance Report June 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report June 2011 DOE/RL-2009-113 REV 21 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report June 2011 DOE/RL-2009-113 REV 21 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  8. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 Monthly Performance Report March 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report March 2011 DOE/RL-2009-113 REV 18 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report March 2011 DOE/RL-2009-113 REV 18 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  9. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 Monthly Performance Report May 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report May 2011 DOE/RL-2009-113 REV 20 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report May 2011 DOE/RL-2009-113 REV 20 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  10. MSC Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 Monthly Performance Report November 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report Nov 2011 DOE/RL-2009-113 Rev 26 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report Nov 2011 DOE/RL-2009-113 Rev 26 iii CONTENTS EXECUTIVE OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key

  11. Uranium Marketing Annual Report -

    Gasoline and Diesel Fuel Update (EIA)

    b. Uranium purchased by owners and operators of U.S. civilian nuclear power reactors ranked by price and distributed by purchaser, 2012-14 deliveries thousand pounds U3O8 equivalent; dollars per pound U3O8 equivalent Deliveries in 2012 Deliveries in 2013 Deliveries in 2014 Distribution of purchasers Number of purchasers Quantity with reported price Weighted-average price Number of purchasers Quantity with reported price Weighted-average price Number of purchasers Quantity with reported price

  12. UPC Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reports UPC Bug Reports Viewing entries posted in October 2014 Deadlock during first touch of upc_alloc'd remote memory when target is in upc_barrier [updated] October 16, 2014 Status: This has been reported to Cray (811537) and a workaround is available. Fixed in CCE 8.3.5. Read the full post Subscribe via RSS Subscribe Browse by Date October 2014 Last edited: 2016-04-29 11:34:42

  13. Annual Coal Report 2014

    U.S. Energy Information Administration (EIA) Indexed Site

    Annual Coal Report 2014 March 2016 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data, analyses, and forecasts are independent of approval by any other officer or employee of the United States Government. The views in this report therefore should not be construed as representing

  14. House Simulation Protocols Report

    Broader source: Energy.gov [DOE]

    Building America's House Simulation Protocols report is designed to assist researchers in tracking the progress of multiyear, whole-building energy reduction against research goals for new and...

  15. Sludge adherence summary report

    SciTech Connect (OSTI)

    Bergmann, D.W., Westinghouse Hanford

    1996-07-11

    This report summarizes the results from the first sludge adherence tests performed in the 105-K East Basin on N Reactor fuel.

  16. TPO's Acceptance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TECHNICAL PROJECT OFFICER'S ACCEPTANCE REPORT DATE OF REQUEST: AWARD NUMBER: DE- AWARD PERIOD FROM: TO: NAME OF AWARDEE: PROJECT TITLE: OVERALL RATING OF AWARDEE'S PERFORMANCE ...

  17. Understanding LM-79 Reports

    SciTech Connect (OSTI)

    none,

    2012-03-01

    Solid-state lighting program technology fact sheet that discusses typical content of laboratory reports summarizing LM-79 test results for integrated SSL lamps and luminaires.

  18. Product Pipeline Reports Tutorial

    U.S. Energy Information Administration (EIA) Indexed Site

    Petroleum > Petroleum Survey Forms> Petroleum Survey Forms Tutorial Product Pipeline Reports Tutorial Content on this page requires a newer version of Adobe Flash Player. Get Adobe ...

  19. 2007 Annual Report

    SciTech Connect (OSTI)

    2007-01-01

    This annual report includes: a brief overview of Western; FY 2007 highlights; FY 2007 Integrated Resource Planning, or IRP, survey; and financial data.

  20. Intel Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 C++11 header files appear missing on Edison December 3, 2014 by Scott French, NERSC USG Status: Reported to Cray (801693), Workaround available

  1. EMSL 2009 Annual Report

    SciTech Connect (OSTI)

    Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.; Wiley, Julie G.; Reed, Jennifer R.

    2010-02-26

    The EMSL 2009 Annual Report describes the science conducted at EMSL during 2009 as well as outreach activities and awards and honors received by users and staff.

  2. PGI Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    June 2015 Internal compiler error for function pointer with identically named arguments June 9, 2015 by Scott French, NERSC USG Status: Bug 21435 reported to PGI

  3. FY 2009 LDRD Report

    Broader source: Energy.gov [DOE]

    The national laboratories included in this report devoted approximately $515 million to LDRD, addressing topics that span the entire range of DOE’s broad scientific mandate.

  4. FY 2008 LDRD Report

    Broader source: Energy.gov [DOE]

    The national laboratories included in this report devoted approximately $513 million to LDRD, addressing topics that span the entire range of DOE’s broad scientific mandate.

  5. OHA 2013 ANNUAL REPORT

    Broader source: Energy.gov [DOE]

    Report on the FY 2013 operations of the Office of Hearings and Appeals (OHA). Here are highlights for the past year:

  6. 2001 SITE ENVIRONMENTAL REPORT

    SciTech Connect (OSTI)

    BROOKHAVEN NATIONAL LABORATORY

    2002-09-01

    THE SITE ENVIRONMENTAL REPORT FOR BROOKHAVEN NATIONAL LABORATORY FOR THE CALENDAR YEAR 2001, AS REQUIRED BY DOE ORDER 231.1.

  7. IG-0702 Report Cover

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... upon the ease of entry, retrieval and reporting issues). ... 2. What additional information related to findings and ... through the Internet at the following address: ...

  8. OHA 2015 ANNUAL REPORT

    Broader source: Energy.gov [DOE]

    Report on the FY 2015 operations of the Office of Hearings and Appeals (OHA). Here are highlights for the past year:

  9. PGI Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pgipgi-bug-reportsrss Internal compiler error for function pointer with identically named arguments http:www.nersc.govuserssoftwarecompilerspgipgi-bug-reports...

  10. CAF Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    caf-coarray-fortrancaf-bug-reportsrss There are currently no significant reported user bugs with CAF. http:www.nersc.govuserssoftwarecompilerscaf-coarray-fortran...

  11. 1999 Site Environmental Report

    SciTech Connect (OSTI)

    2000-09-01

    The Site Environmental Report for Brookhaven National Laboratory for the calendar year 1999, as required by DOE Order 231.1.

  12. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... to provide an executive-level performance overview. ... Report JAN 2012 DOERL-2009-113 Rev 28 2 of ... - MSA Information Management (IM) continues ...

  13. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Report APR 2012 DOERL-2009-113 Rev 31 2 their ... These charts provide management with an early indicator of ... Calibration activities commenced in April 2012. Waste ...

  14. Weekly Petroleum Status Report

    U.S. Energy Information Administration (EIA) Indexed Site

    ... Oilgram Price Report. * Petroleum Intelligence Weekly. * Oil and Gas Journal. * Wall Street Journal. * Oil Market Intelligence. * Natural Resources Canada * Petroleum Place ...

  15. International petroleum statistics report

    SciTech Connect (OSTI)

    1996-08-01

    This report provides information on current international petroleum production, demand, imports, and stocks. World oil demand and OECD demand data are presented for the years 1970 thru 1995.

  16. 2007 Site Environmental Report

    SciTech Connect (OSTI)

    Ratel,K.

    2008-10-01

    Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy. The report is written to inform the public, regulators, employees, and other stakeholders of the Laboratory's environmental performance during the calendar year in review. Volume I of the SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and performance in restoration and surveillance monitoring programs. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. Volume II of the SER, the Groundwater Status Report, also is prepared annually to report on the status of and evaluate the performance of groundwater treatment systems at the Laboratory. Volume II includes detailed technical summaries of groundwater data and its interpretation, and is intended for internal BNL users, regulators, and other technically oriented stakeholders. A brief summary of the information contained in Volume II is included in this volume in Chapter 7, Groundwater Protection. Both reports are available in print and as downloadable files on the BNL web page at http://www.bnl.gov/ewms/ser/. An electronic version on compact disc is distributed with each printed report. In addition, a summary of Volume I is prepared each year to provide a general overview of the report, and is distributed with a compact disc containing the-length report.

  17. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... each project, eliminating daily and weekly reporting and ... in support of spent fuel activities. 9302014 Bird ... Move Coordination and Scheduling - Land & Facilities ...

  18. Audit Report: IG-0749

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Due to security vulnerability considerations. the report does not make a direct connection ... of Energy and the Under Secretary for Science concurred with the audit recommendations. ...

  19. 1994 Site Environmental Report

    SciTech Connect (OSTI)

    1995-05-01

    The 1994 Site Environmental Report summarizes environmental activities at Lawrence Berkeley Laboratory (LBL) for the calendar year (CY) 1994. The report strives to present environmental data in a manner that characterizes the performance and compliance status of the Laboratory`s environmental management programs when measured against regulatory standards and DOE requirements. The report also discusses significant highlight and planning efforts of these programs. The format and content of the report are consistent with the requirements of the US Department of Energy (DOE) Order 5400.1, General Environmental Protection Program.

  20. Cray Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    C++ predefined RELEASE macro returns wrong value updated November 18, 2013 by Mike Stewart, NERSC USG Status: Reported to Cray as bug 797442, became documentation bug 805340....

  1. Navigant Market Report 2014

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    this report, the authors thank the entire U.S. Department of Energy (DOE) Wind & Water Power Technologies Office, particularly Patrick Gilman and Michael Hahn. Navigant would also...

  2. Capital Reporting Company

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... investment. 16 One theory of the case is they ... a need for a new transmission line, and Capital Reporting ... Elliott. 12 Carl, any comment? 13 MR. ZICHELLA: Yeah. ...

  3. Final Project Report

    SciTech Connect (OSTI)

    Wang, Qiang; Dandy, David S.

    2015-05-15

    This is the final technical report of the DOE project DE-FG02-07ER46448 awarded to Colorado State University.

  4. WACR Calibration Report

    SciTech Connect (OSTI)

    Mead, D

    2010-03-23

    Calibration report for the W-Band (95 GHz) ARM Cloud Radar performed for the ARM Climate Research Facility by ProSensing Inc.

  5. Final Technical Report

    SciTech Connect (OSTI)

    Herrin, David L

    2011-04-21

    This report summarizes many of the projects, and lists all of the publications and persons trained with support from the grant.

  6. Progress Report for Workgroup ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    would need mechanism to ensure regular reporting of savings o Under program evaluation option, what would standards be for determining whether state audits could replace...

  7. Table for Reports - ESG

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory (PDF) Worker and Environmental Assessment of Potential Unbound Engineered Nanoparticle Releases Phase I Final Report: Data Collection, 2009 (PDF) Phase II Final...

  8. BPA 2002 Annual Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    STATEMENTS 2002 Annual Report of the Bonneville Power Administration Cover photo BPA fish biologist Andy Thoms (upper right) works with students from H.B. Lee Middle School...

  9. International Subcommittee Report

    Broader source: Energy.gov (indexed) [DOE]

    Report Dr. Regis A. Matzie, Chair NEAC Meeting December 10, 2014 1 Externalities of Nuclear Power Important International Considerations Safety - because of the potential...

  10. DOE Final Report

    SciTech Connect (OSTI)

    Hinzman, Larry D.; Long, James; Newby, Greg B.

    2014-01-08

    This final report contains a summary of work accomplished in the establishment of a Climate Data Center at the International Arctic Research Center, University of Alaska Fairbanks.

  11. Capital Reporting Company Quadrennial ...

    Broader source: Energy.gov (indexed) [DOE]

    2014 1 QUADRENNIAL ENERGY REVIEW STAKEHOLDER MEETING 3 PETROLEUM ... Capital Reporting Company Quadrennial Energy Review Stakeholder Meeting 3 05-27-2014 ...

  12. Capital Reporting Company Quadrennial ...

    Broader source: Energy.gov (indexed) [DOE]

    2014 1 QUADRENNIAL ENERGY REVIEW PUBLIC MEETING 10: Infrastructure ... Capital Reporting Company Quadrennial Energy Review 08-11-2014 (866) 448 - DEPO ...

  13. 2015 Uranium Marketing Annual Report

    U.S. Energy Information Administration (EIA) Indexed Site

    Uranium Marketing Annual Report 2015 Uranium Marketing Annual Report Release Date: May 24, 2016 Next Release Date: May 2017 Number of purchasers Quantity with reported price ...

  14. Environmental Report 2008

    SciTech Connect (OSTI)

    Gallegos, G; Bertoldo, N A; Campbell, C G; Cerruti, S; Dibley, V; Doman, J L; Grayson, A R; Jones, H E; Kumamoto, G; MacQueen, D H; Nelson, J C; Paterson, L; Revelli, M A; Wegrecki, A M; Wilson, K; Woollett, J

    2009-09-16

    The purposes of the Lawrence Livermore National Laboratory Environmental Report 2008 are to record Lawrence Livermore National Laboratory's (LLNL's) compliance with environmental standards and requirements, describe LLNL's environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites - the Livermore site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL's Environmental Protection Department. Submittal of the report satisfies requirements under DOE Order 231.1A, Environmental Safety and Health Reporting, and DOE Order 5400.5, Radiation Protection of the Public and Environment. The report is distributed electronically and is available at https://saer.lln.gov/, the website for the LLNL annual environmental report. Previous LLNL annual environmental reports beginning in 1994 are also on the website. Some references in the electronic report text are underlined, which indicates that they are clickable links. Clicking on one of these links will open the related document, data workbook, or website that it refers to. The report begins with an executive summary, which provides the purpose of the report and an overview of LLNL's compliance and monitoring results. The first three chapters provide background information: Chapter 1 is an overview of the location, meteorology, and hydrogeology of the two LLNL sites; Chapter 2 is a summary of LLNL's compliance with environmental regulations; and Chapter 3 is a description of LLNL's environmental programs with an emphasis on the Environmental Management System including pollution prevention. The majority of the report covers LLNL's environmental monitoring programs and monitoring data for 2008: effluent and ambient air (Chapter 4); waters, including wastewater, storm water runoff, surface water, rain, and groundwater (Chapter 5); and terrestrial, including soil, sediment, vegetation, foodstuff, ambient radiation, and special status wildlife and plants (Chapter 6). Complete monitoring data, which are summarized in the body of the report, are provided in Appendix A. The remaining three chapters discuss the radiological impact on the public from LLNL operations (Chapter 7), LLNL's groundwater remediation program (Chapter 8), and quality assurance for the environmental monitoring programs (Chapter 9). The report uses Systeme International units, consistent with the federal Metric Conversion Act of 1975 and Executive Order 12770, Metric Usage in Federal Government Programs (1991). For ease of comparison to environmental reports issued prior to 1991, dose values and many radiological measurements are given in both metric and U.S. customary units. A conversion table is provided in the glossary. The report is the responsibility of LLNL's Environmental Protection Department. Monitoring data were obtained through the combined efforts of the Environmental Protection Department; Environmental Restoration Department; Physical and Life Sciences Environmental Monitoring Radiation Laboratory; and the Hazards Control Department.

  15. Microhole Tubing Bending Report

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Oglesby, Ken

    2012-01-01

    A downhole tubing bending study was made and is reported herein. IT contains a report and 2 excel spreadsheets to calculate tubing bending and to estimate contact points of the tubing to the drilled hole wall (creating a new support point).

  16. Microhole Tubing Bending Report

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Oglesby, Ken

    A downhole tubing bending study was made and is reported herein. IT contains a report and 2 excel spreadsheets to calculate tubing bending and to estimate contact points of the tubing to the drilled hole wall (creating a new support point).

  17. Inert Anode Report

    SciTech Connect (OSTI)

    none,

    1999-07-01

    This ASME report provides a broad assessment of open literature and patents that exist in the area of inert anodes and their related cathode systems and cell designs, technologies that are relevant for the advanced smelting of aluminum. The report also discusses the opportunities, barriers, and issues associated with these technologies from a technical, environmental, and economic viewpoint.

  18. Environmental Report 2007

    SciTech Connect (OSTI)

    Mathews, S; Gallegos, G; Berg, L L; Bertoldo, N A; Campbell, C G; Cerruti, S; Doman, J L; Ferry, L S; Grayson, A R; Jones, H E; Kumamoto, G; Larson, J; MacQueen, D H; Paterson, L; Revelli, M A; Ridley, M; Rueppel, D; Wegrecki, A M; Wilson, K; Woollett, J

    2008-09-24

    The purposes of the 'Lawrence Livermore National Laboratory Environmental Report 2007' are to record Lawrence Livermore National Laboratory's (LLNL's) compliance with environmental standards and requirements, describe LLNL's environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites--the Livermore site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL's Environmental Protection Department. Submittal of the report satisfies requirements under DOE Order 231.1A, Environmental Safety and Health Reporting, and DOE Order 5400.5, Radiation Protection of the Public and Environment. The report is distributed electronically and is available at https://saer.lln.gov/, the website for the LLNL annual environmental report. Previous LLNL annual environmental reports beginning in 1994 are also on the website. Some references in the electronic report text are underlined, which indicates that they are clickable links. Clicking on one of these links will open the related document, data workbook, or website that it refers to. The report begins with an executive summary, which provides the purpose of the report and an overview of LLNL's compliance and monitoring results. The first three chapters provide background information: Chapter 1 is an overview of the location, meteorology, and hydrogeology of the two LLNL sites; Chapter 2 is a summary of LLNL's compliance with environmental regulations; and Chapter 3 is a description of LLNL's environmental programs with an emphasis on the Environmental Management System including pollution prevention. The majority of the report covers LLNL's environmental monitoring programs and monitoring data for 2007: effluent and ambient air (Chapter 4); waters, including wastewater, storm water runoff, surface water, rain, and groundwater (Chapter 5); and terrestrial, including soil, sediment, vegetation, foodstuff, ambient radiation, and special status wildlife and plants (Chapter 6). Complete monitoring data, which are summarized in the body of the report, are provided in Appendix A. The remaining three chapters discuss the radiological impact on the public from LLNL operations (Chapter 7), LLNL's groundwater remediation program (Chapter 8), and quality assurance for the environmental monitoring programs (Chapter 9). The report uses Systeme International units, consistent with the federal Metric Conversion Act of 1975 and Executive Order 12770, Metric Usage in Federal Government Programs (1991). For ease of comparison to environmental reports issued prior to 1991, dose values and many radiological measurements are given in both metric and U.S. customary units. A conversion table is provided in the glossary.

  19. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    SciTech Connect (OSTI)

    Venhuizen, James Robert

    2002-04-01

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  20. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    SciTech Connect (OSTI)

    Venhuizen, James R.

    2002-04-30

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  1. ARM - ARM Operations Quarterly Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Operations Quarterly Reports Publications Journal Articles Conference Documents Program Documents Technical Reports Publications Database Public Information Materials Image Library...

  2. SU-E-T-68: Clinical Implementation of Total Skin Electron Beam Therapy: A New- York Presbyterian Hospital Experience

    SciTech Connect (OSTI)

    Afghan, M; Shih, R; Chen, H

    2014-06-01

    Purpose: Total skin electron beam therapy (TSET) is used in the treatment of rare skin diseases such as mycosis fungoides, the most common type of cutaneous T-cell lymphoma. We report our experience with clinical implementation of TSET. Methods: A modified six-dual-field irradiation technique was chosen to deliver TSET. A Varian Trilogy linear accelerator with a nominal 6 MeV beam using high dose rate total skin electron mode (HDTSe) was employed. The recommendations of AAPM task group report 23 were followed for the commissioning. An acrylic plate (energy degrader) of 3.2 mm depth was mounted on the HDTSe applicator. The nominal source to skin distance was set at 450 cm. The optimum tilt angle of the gantry was determined using NACP-02 ionization chamber embedded in certified therapy grade solid water. Percent depth dose measurements were performed using ionization chamber and radiochromic films embedded in solid water and anthropomorphic phantom. For absolute dose measurements, TG-51 formalism was employed. The dose distribution on the entire skin was measured by irradiating the anthropomorphic phantom, with TLDs attached, mimicking the real treatment. Results: The 3.2 mm acrylic plate mounted on the HDTSe applicator degraded the energy of the electron beam to 4.1 MeV in the treatment plane, located at an SSD of 450 cm. The optimum tilt angle was found to be 20. A single-dual field had a longitudinal uniformity, measured at a depth of dose maximum, of 7% over a length of about 200 cm. For the entire treatment the multiplication factor was found to be 2.86. On the surface of the phantom, the dose varied from 108% to 93% of the prescription dose. Conclusion: We have successfully commissioned TSET meeting the guidelines of the TG report 23, and treated our first patient on February 25, 2014.

  3. Imaging Changes in Pediatric Intracranial Ependymoma Patients Treated With Proton Beam Radiation Therapy Compared to Intensity Modulated Radiation Therapy

    SciTech Connect (OSTI)

    Gunther, Jillian R.; Sato, Mariko; Chintagumpala, Murali; Ketonen, Leena; Jones, Jeremy Y.; Allen, Pamela K.; Paulino, Arnold C.; Okcu, M. Fatih; Su, Jack M.; Weinberg, Jeffrey; Boehling, Nicholas S.; Khatua, Soumen; Adesina, Adekunle; Dauser, Robert; Whitehead, William E.; Mahajan, Anita

    2015-09-01

    Purpose: The clinical significance of magnetic resonance imaging (MRI) changes after radiation therapy (RT) in children with ependymoma is not well defined. We compared imaging changes following proton beam radiation therapy (PBRT) to those after photon-based intensity modulated RT (IMRT). Methods and Materials: Seventy-two patients with nonmetastatic intracranial ependymoma who received postoperative RT (37 PBRT, 35 IMRT) were analyzed retrospectively. MRI images were reviewed by 2 neuroradiologists. Results: Sixteen PBRT patients (43%) developed postradiation MRI changes at 3.8 months (median) with resolution by 6.1 months. Six IMRT patients (17%) developed changes at 5.3 months (median) with 8.3 months to resolution. Mean age at radiation was 4.4 and 6.9 years for PBRT and IMRT, respectively (P=.06). Age at diagnosis (>3 years) and time of radiation (≥3 years) was associated with fewer imaging changes on univariate analysis (odds ratio [OR]: 0.35, P=.048; OR: 0.36, P=.05). PBRT (compared to IMRT) was associated with more frequent imaging changes, both on univariate (OR: 3.68, P=.019) and multivariate (OR: 3.89, P=.024) analyses. Seven (3 IMRT, 4 PBRT) of 22 patients with changes had symptoms requiring intervention. Most patients were treated with steroids; some PBRT patients also received bevacizumab and hyperbaric oxygen therapy. None of the IMRT patients had lasting deficits, but 2 patients died from recurrent disease. Three PBRT patients had persistent neurological deficits, and 1 child died secondarily to complications from radiation necrosis. Conclusions: Postradiation MRI changes are more common with PBRT and in patients less than 3 years of age at diagnosis and treatment. It is difficult to predict causes for development of imaging changes that progress to clinical significance. These changes are usually self-limiting, but some require medical intervention, especially those involving the brainstem.

  4. Final Technical Report

    Office of Scientific and Technical Information (OSTI)

    1. DOE Award # and Name of the Recipient (Institution) DOE Award #: DE-SC0010385 Name of the Recipient: Prof. Shenqiang Ren University of Kansas Center for Research Chemistry Department/CLAS 1251 Wescoe Hall Drive Lawrence, KS 66045-7568 2. Project Title and Name of the PI Project Title: "Collaborative Research: Polymeric Multiferroics" Name of the PIs: Dr. Shenqiang Ren (The University of Kansas), PI 3. Date of the report and research period covered by the report Date of the Report:

  5. Refinery Capacity Report

    U.S. Energy Information Administration (EIA) Indexed Site

    Capacity Report June 2015 With Data as of January 1, 2015 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data, analyses, and forecasts are independent of approval by any other officer or employee of the United States Government. The views in this report therefore should not be

  6. Weekly Petroleum Status Report

    U.S. Energy Information Administration (EIA) Indexed Site

    All Petrolem Reports Weekly Petroleum Status Report Data for week ending May 20, 2016 | Release Date: May 25, 2016 | Next Release Date: June 2, 2016 | full report Previous Issues Week: May 25, 2016 May 18, 2016 May 11, 2016 May 4, 2016 April 27, 2016 April 20, 2016 April 13, 2016 April 6, 2016 March 30, 2016 March 23, 2016 March 16, 2016 March 9, 2016 March 2, 2016 prior issues Go The petroleum supply situation in the context of historical information and selected prices. Released after 10:30

  7. International petroleum statistics report

    SciTech Connect (OSTI)

    1995-10-01

    The International Petroleum Statistics Report is a monthly publication that provides current international oil data. This report presents data on international oil production, demand, imports, exports and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Section 2 presents an oil supply/demand balance for the world, in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  8. Report Wildlife Encounters

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wildlife Encounters Report Wildlife Encounters Report any encounters with wildlife in the Los Alamos area. April 12, 2012 A mama black bear and her cub A mama black bear and her cub in Los Alamos. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email If you find an injured bird, contact the Santa Fe Raptor Center. Have a close encounter? Report the following Any wildlife incidents or encounters Migratory bird injury or

  9. Intel Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Intel » Intel Bug Reports Intel Bug Reports Intel C++ compiler error: stl_iterator_base_types.h December 7, 2015 by Scott French Because the system-supplied version of GCC is relatively old (4.3.4) it is common practice to load the gcc module on our Cray systems when C++11 support is required under the Intel C++ compilers. Read the full post C++11 header files appear missing on Edison December 3, 2014 by Scott French, NERSC USG Status: Reported to Cray (801693), Workaround available Read the

  10. Uranium Marketing Annual Report -

    Gasoline and Diesel Fuel Update (EIA)

    a. Uranium purchased by owners and operators of U.S. civilian nuclear power reactors ranked by price and distributed by quantity, 2012-14 deliveries thousand pounds U3O8 equivalent; dollars per pound U3O8 equivalent Deliveries in 2012 Deliveries in 2013 Deliveries in 2014 Quantity 1 distribution Quantity with reported price Weighted-average price Quantity with reported price Weighted-average price Quantity with reported price Weighted-average price First 7,119 38.24 7,175 34.24 6,665 30.26

  11. Uranium Marketing Annual Report -

    Gasoline and Diesel Fuel Update (EIA)

    7. Uranium purchased by owners and operators of U.S. civilian nuclear power reactors by contract type and material type, 2014 deliveries thousand pounds U3O8 equivalent; dollars per pound U3O8 equivalent Spot 1 Contracts Long-Term Contracts 2 Total Material Type Quantity with reported price Weighted-average price Quantity with reported price Weighted-average price Quantity with reported price Weighted-average price U3O8 8,440 38.38 20,820 47.57 29,260 44.92 Natural UF6 4,405 35.30 13,373 53.13

  12. System and method for delivery of neutron beams for medical therapy

    DOE Patents [OSTI]

    Nigg, David W. (Idaho Falls, ID); Wemple, Charles A. (Idaho Falls, ID)

    1999-01-01

    A neutron delivery system that provides improved capability for tumor control during medical therapy. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention.

  13. Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    2003-05-20

    The present invention covers halogenated derivatives of boronated porphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron- capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

  14. Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    2005-10-04

    The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

  15. System and method for delivery of neutron beams for medical therapy

    DOE Patents [OSTI]

    Nigg, D.W.; Wemple, C.A.

    1999-07-06

    A neutron delivery system that provides improved capability for tumor control during medical therapy is disclosed. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention. 5 figs.

  16. On bolus for megavoltage photon and electron radiation therapy

    SciTech Connect (OSTI)

    Vyas, Vedang; Palmer, Lisa; Mudge, Ray; Jiang, Runqing; Fleck, Andre; Schaly, Bryan; Osei, Ernest; Charland, Paule

    2013-10-01

    Frequently, in radiation therapy one must treat superficial lesions on cancer patients; these are at or adjacent to the skin. Megavoltage photon radiotherapy penetrates through the skin to irradiate deep-seated tumors, with skin-sparing property. Hence, to treat superficial lesions, one must use a layer of scattering material to feign as the skin surface. Although megavoltage electron beams are used for superficial treatments, one occasionally needs to enhance the dose near the surface. Such is the function of a bolus, a natural or synthetically developed material that acts as a layer of tissue to provide a more effective treatment to the superficial lesions. Other uses of boluses are to correct for varying surface contours and to add scattering material around the patient's surface. Materials used as bolus vary from simple water to metal and include various mixtures and compounds. Even with the modernization of the technology for external-beam therapy and the emergence of various commercial boluses, the preparation and utilization of a bolus in clinical radiotherapy remains an art. Considering the varying experiences and practices, this paper briefly summarizes available boluses that have been proposed and are employed in clinical radiotherapy. Although this review is not exhaustive, it provides some initial guidance and answers questions that may arise in clinical practice.

  17. Outcomes and Acute Toxicities of Proton Therapy for Pediatric Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System

    SciTech Connect (OSTI)

    McGovern, Susan L.; Okcu, M. Fatih; Munsell, Mark F.; Kumbalasseriyil, Nancy; Grosshans, David R.; McAleer, Mary F.; Chintagumpala, Murali; Khatua, Soumen; Mahajan, Anita

    2014-12-01

    Purpose: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a rare cancer primarily affecting children younger than 5 years old. Because patients are young and receive intensive chemotherapy, there is concern regarding late radiation toxicity, particularly as survival rates improve. Therefore, there is interest in using proton therapy to treat these tumors. This study was undertaken to investigate outcomes and acute toxicities associated with proton therapy for AT/RT. Methods and Materials: The records of 31 patients with AT/RT treated with proton radiation from October 2008 to August 2013 were reviewed. Demographics, treatment characteristics, and outcomes were recorded and analyzed. Results: Median age at diagnosis was 19 months (range, 4-55 months), with a median age at radiation start of 24 months (range, 6-62 months). Seventeen patients received local radiation with a median dose of 50.4 GyRBE (range, 9-54 GyRBE). Fourteen patients received craniospinal radiation; half received 24 GyRBE or less, and half received 30.6 GyRBE or more. For patients receiving craniospinal radiation, the median tumor dose was 54 GyRBE (range, 43.2-55.8 GyRBE). Twenty-seven patients (87%) completed the planned radiation. With median follow-up of 24 months for all patients (range, 3-53 months), median progression-free survival was 20.8 months and median overall survival was 34.3 months. Five patients (16%) developed clinical findings and imaging changes in the brainstem 1 to 4 months after radiation, consistent with radiation reaction; all cases resolved with steroids or bevacizumab. Conclusions: This is the largest report of children with AT/RT treated with proton therapy. Preliminary survival outcomes in this young pediatric population are encouraging compared to historic results, but further study is warranted.

  18. A Spectrum of Nerve Injury after Thermal Ablation: A Report of Four Cases and Review of the Literature

    SciTech Connect (OSTI)

    Philip, Asher; Gupta, Sanjay Ahrar, Kamran Tam, Alda L.

    2013-10-15

    Thermal ablation is an accepted alternative for the palliation of pain from bone metastases. Although rare, neurologic complications after thermal ablation have been reported. We present four cases, including two cases of rapid reversal of postcryoablation neurapraxia after the administration of steroid therapy, and review the literature.

  19. Report Wildlife Encounters

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Encounters Report any encounters with wildlife in the Los Alamos area. April 12, 2012 A mama black bear and her cub A mama black bear and her cub in Los Alamos. Contact...

  20. Intel Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    November 2013 Compiling with -ipo produces "unresolved" warning messages at link time on Cray systems November 18, 2013 by Mike Stewart, NERSC USG Status: Reported to the darshan developers

  1. 2010 Annual Report

    SciTech Connect (OSTI)

    2010-01-01

    This annual report includes: an overview of Western; approaches for future hydropower and transmission service; major achievements in FY 2010; FY 2010 customer Integrated Resource Planning, or IRP, survey; and financial data.

  2. ARM - Daily Report Archive

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... to the convective area (aerosols and chemistry) Egrett reported water at -37C, but icing at -47C? 23: aged cirrus mission (twin otter and egrett) system had stratiform rain at ...

  3. ARM - Reporting Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    required to report to the DOE ARM Program Director, to the DOE's Office of Biological and Environmental Research, and to the White House Office of Management and Budget. A primary...

  4. RPSEA REPORT PROCEDURES

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    RPSEA Final Technical Report 08121.2201.02.FINAL Heavy Viscous Oil Pressure, Volume, and Temperature 08121-2201-02 February 4, 2015 Hongying Zhao Project Manager, PhD, PEng ...

  5. JPRS report, nuclear developments

    SciTech Connect (OSTI)

    1991-03-28

    This report contains articles concerning the nuclear developments of the following countries: (1) China; (2) Japan, North Korea, South Korea; (3) Bulgaria; (4) Argentina, Brazil, Honduras; (5) India, Iran, Pakistan, Syria; (6) Soviet Union; and (7) France, Germany, Turkey.

  6. 2002 SITE ENVIRONMENTAL REPORT.

    SciTech Connect (OSTI)

    BROOKHAVEN NATIONAL LABORATORY

    2003-10-01

    The 2002 Site Environmental Report (SER) is prepared in accordance with DOE Order 231.1, ''Environment, Safety and Health Reporting'', and summarizes the status of Brookhaven National Laboratory's (BNL) environmental programs and performance and restoration efforts, as well as any impacts, both past and present, that Laboratory operations have had on the environment. The document is intended to be technical in nature. A summary of the report is also prepared as a separate document to provide a general overview and includes a CD version of the full report. Operated by Brookhaven Science Associates (BSA) for the Department of Energy (DOE), BNL manages its world-class scientific research with particular sensitivity to environmental and community issues. BNL's motto, ''Exploring Life's Mysteries...Protecting its Future'', reflects BNL's management philosophy to fully integrate environmental stewardship into all facets of its missions, with a health balance between science and the environment.

  7. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Nov-12 Dec-12 Jan-13 Feb-13 Mar-13 Apr-13 ... First Aid 12-Month Average FY 4.22 CY 4.74 EXECUTIVE OVERVIEW EXECUTIVE OVERVIEW MSC Monthly Performance Report MAY 2013 ...

  8. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... days or through December 22, 2014 RL20 - 43.7 working ... that require more than first aid and must be reported. ... 3.00 Nov-13 Dec-13 Jan-14 Feb-14 Mar-14 Apr-14 May-14 ...

  9. Blackout Final Implementation Report

    Energy Savers [EERE]

    ... DOE's review, and the May 2005 report on DME requirements by the NERC Interconnec- tion ... R.15.A.4. In addition to NERC's requirement for inspection and testing of all reactive ...

  10. Weekly Petroleum Status Report

    U.S. Energy Information Administration (EIA) Indexed Site

    See the Petroleum Supply Monthly for updated data or the Petroleum Supply Annual for final data. 2 Countries reported represent the top 10 countries based on annual import volumes ...

  11. Transportation Baseline Report

    SciTech Connect (OSTI)

    Fawcett, Ricky Lee; Kramer, George Leroy Jr.

    1999-12-01

    The National Transportation Program 1999 Transportation Baseline Report presents data that form a baseline to enable analysis and planning for future Department of Energy (DOE) Environmental Management (EM) waste and materials transportation. In addition, this Report provides a summary overview of DOEs projected quantities of waste and materials for transportation. Data presented in this report were gathered as a part of the IPABS Spring 1999 update of the EM Corporate Database and are current as of July 30, 1999. These data were input and compiled using the Analysis and Visualization System (AVS) which is used to update all stream-level components of the EM Corporate Database, as well as TSD System and programmatic risk (disposition barrier) information. Project (PBS) and site-level IPABS data are being collected through the Interim Data Management System (IDMS). The data are presented in appendices to this report.

  12. International petroleum statistics report

    SciTech Connect (OSTI)

    1996-12-01

    This report presents data on international oil production, demand, imports, and stocks. World oil production and OECD demand data are for the years 1970 through 1995; stocks from 1973 through 1995, and trade from 1985 through 1995.

  13. International petroleum statistics report

    SciTech Connect (OSTI)

    1996-03-01

    This report presents data on international oil production, demand, imports, exports, and stocks. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1984 through 1994.

  14. Final Technical Report

    SciTech Connect (OSTI)

    Ritchie, Jack L

    2012-07-26

    The activity reported includes work on several experiments (BNL E871 at Brookhaven National Lab, HERA-B at DESY, MINOS at Fermilab, BABAR at SLAC, and Minerva at Fermilab) and theory.

  15. GNU Bug Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    no significant reported user bugs with the GNU compilers. November 18, 2013 by Mike Stewart, NERSC USG. Status: No current NERSC user bugs. Read the full post Subscribe via RSS...

  16. Complex Flow Workshop Report

    SciTech Connect (OSTI)

    none,

    2012-05-01

    This report documents findings from a workshop on the impacts of complex wind flows in and out of wind turbine environments, the research needs, and the challenges of meteorological and engineering modeling at regional, wind plant, and wind turbine scales.

  17. HEP Final Project Report

    SciTech Connect (OSTI)

    Chen, Chunhui

    2013-05-21

    In this report, we summarize the research activity funded by the DOE award DE-FG02-12ER41827 (DE-SC0007892) during the funding period (May 1, 2012- March 31, 2013).

  18. Aurora final report

    SciTech Connect (OSTI)

    Robert, Dross; Amedeo, Conti

    2013-12-06

    Final Technical report detailing the work done by Nuvera and its partners to fulfill the goals of the program "Transport Studies Enabling Efficiency Optimization of Cost-Competitive Fuel Cell Stacks" (a.k.a. AURORA)

  19. Report from the Street

    Energy Savers [EERE]

    SHERMAN STREET, CAMBRIDGE, MA 02140 617.354.4502 LAMPARTNERS.COM BLOG.LAMPARTNERS.COM Report from the Street Glenn Heinmiller, FIALD, LC, LEED AP Principal, Lam Partners Chair,...

  20. SWERA_Final_Report

    Open Energy Info (EERE)

    throughout the day such as trough collectors or dishes. The estimation for radiation on 3 Solar Energy Resources, Technical Report 3, CESEN 1986 2-2 tilted surface analysis used...

  1. CX-100 Final Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SAND2008-4648 Unlimited Release Printed July 2008 Blade System Design Studies Phase II: Final Project Report Derek S. Berry TPI Composites, Inc. 373 Market Street Warren, RI 02885...

  2. 2009 Annual Report

    SciTech Connect (OSTI)

    2009-01-01

    This annual report includes: a brief overview of Western; some of our major achievements in FY 2009; FY 2009 customer Integrated Resource Planning, or IRP, survey; and financial data.

  3. ARM - Technical Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Report (PDF, 1.4MB) ProSensing Inc. 2010 Whole Sky Imager Retrieval Guide (PDF, 2.0MB) ... Shaw, RA, M Beals, JP Fugal, SM Spuler, N Black, and J Lu 2012 ARM Standards Policy ...

  4. Monthly Reports 2014

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Waste Isolation Pilot Plant Hazardous Waste Facility Permit Number: NM4890139088-TSDF Jose R. FrancoCBFO and Robert L. McQuinnNWP dated December 29, 2014 Monthly Report for the...

  5. Weekly Reports 2014

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Waste Isolation Pilot Plant Hazardous Waste Facility Permit Number: NM4890139088-TSDF Jose R. FrancoCBFO and Robert L. McQuinnNWP dated May 27, 2014 Weekly Report as Requested...

  6. Capital Reporting Company Quadrenntial ...

    Broader source: Energy.gov (indexed) [DOE]

    Energy Review 04-21-2014 (866) 448 - DEPO www.CapitalReportingCompany.com 2014 1 NEW ENGLAND REGIONAL INFRASTRUCTURE CONSTRAINTS A Public Meeting on the Quadrennial Energy ...

  7. ALS Activity Report 2004

    SciTech Connect (OSTI)

    Tamura , Lori S.

    2005-07-11

    This annual report of the Advanced Light Source details science highlights and facility developments during the year. It also offers information on events sponsored by the facility, technical specifications, and staff and publication information.

  8. PMBP_report_110310

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PM Website Contact PM Website Contact Use this form to send us your comments, report problems, and/or ask questions about information on the PM website. Your Email Message Here CAPTCHA This question is for testing whether you are a human visitor and to prevent automated spam submissions. Submit

    4 th Workshop on HPC Best Practices: Power Management Held September 28-29, 2010, San Francisco Workshop Report March 2011 Compiled by Kim Cupps and Mary Zosel Lawrence Livermore National Laboratory

  9. Inspection Report: IG-0745

    Energy Savers [EERE]

    and Special Inquiries Inspection Report Material Control and Accountability at Lawrence Livermore National Laboratory Department of Energy Washington, DC 20585 November 15, 2006 MEMORANDUM FOR TH FROM: C 4 z % z & r Inspector General SUBJECT: INFORMATION: Inspection Report on "Material Control and Accountability at Lawrence Livermore National Laboratory" BACKGROUND Lawrence Livermore National Laboratory supports the Department of Energy's core mission of maintaining a safe, secure,

  10. Inspection Report: IG-0746

    Energy Savers [EERE]

    l nspector General Office of Inspections and Special Inquiries Inspection Report Work Packages for Site Support Service; at Los Alamos National Laboratory Department of Energy Washington, DC 20585 November 29, 2006 MEMORANDUM FOR TI38 S E C m U R Y FROM: h p Gregor - . riedman Inspector General SUBJECT: INFORMATION: Inspection Report on "Work Packages for Site Support Services at Los Alalnos National Laboratory" The Department of Energy's Los Alarnos National Laboratory (LANL) enhances

  11. Inspection Report: IG-0821

    Energy Savers [EERE]

    Inspection Report Fire Suppression and Related Services at Los Alamos National Laboratory DOE/IG-0821 September 2009 U.S. Department of Energy Office of Inspector General Office of Inspections Department of Energy Washington, DC 20585 September 11, 2009 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Inspection Report on "Fire Suppression and Related Services at Los Alamos National Laboratory" BACKGROUND The Department of Energy's (DOE's)

  12. LDRD COMPOSITE ANNUAL REPORT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LDRD Annual Report 2010 From the Laboratory Director I am pleased t o have the opportunity t o introduce the 2010 Laboratory Directed Research a n d Dev elopment ( L DRD) Annual Report . T h i s important program displays both the breadth of SRNL's research efforts and the depth of our commitment to expand the capability and mission impact of this Laboratory. We continue to broaden participation in the LDRD program across the Laboratory while maintaining our record of innovative technical

  13. DOE WEEKLY REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    February 20, 2009 The following program office did not submit a Weekly Report for this time period: Energy Information Administration BONNEVILLE POWER ADMINISTRATION WEEKLY REPORT February 20, 2009 Schedule February 25: The Bonneville Power Administration (BPA) Administrator Steve Wright is Chairman of the United States Entity for the Columbia River Treaty. The United States Army Corps of Engineers makes the other component of the United States Entity. Each year, the Canadian and United States

  14. 2011 Peer Review Report

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cover photo: Geysers Geothermal Power Plant, Calpine Geothermal Technologies Program 2011 Peer Review Report June 2011 U.S. Department of Energy Office of Energy Efficiency and Renewable Energy Geothermal Technologies Program 2011 Peer Review Report June 2011 Allan Jelacic Chair 2011 Geothermal Technologies Peer Review Panel Douglas Hollett Program Manager U.S. DOE Geothermal Technologies Program Greg Stillman Peer Review Lead U.S. DOE Geothermal Technologies Program Table of Contents Executive

  15. Annual Site Environmental Report

    SciTech Connect (OSTI)

    Finley, Virginia

    2014-10-02

    This report provides the U.S. Department of Energy (DOE) and the public with information on the level of radioactive and non-radioactive pollutants (if any) that are added to the environment as a result of Princeton Plasma Physics Laboratory’s (PPPL) operations. The results of the 2013 environmental surveillance and monitoring program for PPPL’s are presented and discussed. The report also summarizes environmental initiatives, assessments, and community involvement programs that were undertaken in 2013.

  16. Summary Site Environmental Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Site Environmental Report for Calendar Year 2013 ANL-14/02 (Summary) Environment, Safety, and Quality Assurance Division Argonne National Laboratory For more information about Argonne's Site Environmental Report, contact Theresa Davis, 630.252.6077 or tmdavis@anl.gov. For more information about Argonne and its programs, visit the laboratory's website at www.anl.gov or contact Communications, Education, and Public Affairs, at 630.252.5575. Katherine Obmascik edited the text. Photos by Mark Lopez.

  17. NERSC 2013 Annual Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 Annual Report National Energy Research Scientific Computing Center 2013 Annual Report Ernest Orlando Lawrence Berkeley National Laboratory 1 Cyclotron Road, Berkeley, CA 94720-8148 This work was supported by the Director, Office of Science, Office of Advanced Scientific Computing Research of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. Cover Image Credits: front cover, left to right: Linda Sugiyama, Massachusetts Institute of Technology; IceCube Collaboration; David

  18. HPC Workshop Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HPC Workshop Reports HPC Workshop Reports Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category Petascale Systems Integration into Large Scale Facilities Workshop August 31, 2007 | URL: https://outreach.scidac.gov/pibp/ Download File: PetascaleFinalDraft.doc | doc | 216 KB This workshop was the first given in the HPC Best Practices Workshop Series. Held in San Francisco, May 15-16 2007, the workshop looked at the challenges and opportunities that come with Petascale

  19. Environmental Groundwater Monitoring Report

    Office of Legacy Management (LM)

    -460 Environmental Groundwater Monitoring Report Third Quarter, 1997 October 1997 Approved for public release; further dissemination unlimited. Environmental Restoration U.S. Department of Energy Nevada Operations Office This report has been reproduced directly from the best available copy. 1 - I : ~vailablk to DOE and DOE contractors from the. Office of Scientific - and Technical .Information, P.O. Box 62, Oak Ridge, TN 3783 1 ; prices available from (423) 576-840 1. Available to the public

  20. BES Workshop Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Reports Basic Energy Sciences (BES) BES Home About Research Facilities Science Highlights Benefits of BES Funding Opportunities Basic Energy Sciences Advisory Committee (BESAC) Community Resources Program Summaries Brochures Reports Abstracts Accomplishments Presentations BES and Congress Science for Energy Flow Seeing Matter Nano for Energy Scale of Things Chart Contact Information Basic Energy Sciences U.S. Department of Energy SC-22/Germantown Building 1000 Independence Ave., SW Washington,

  1. Audit Report: IG-0781

    Energy Savers [EERE]

    U.S. Department of Energy Office of Inspector General Office of Audit Services Audit Report Continuity of Operations at Bonneville Power Administration DOE/IG-0781 November 2007 Department of Energy Washington, DC 20585 November 6 , 2007 MEMORANDUM FOR THE ADMINISTRATOR, BONNEVILLE POWER ADMNISTRATION - 2 L ~ ; ; K L & L ~ , ; / FROM: Grego d H. Friedman Inspector General SUBJECT: INFORMATION: Audit Report on "Continuity of Operations at Bonneville Power Administration" BACKGROUND

  2. Blackout Final Implementation Report

    Energy Savers [EERE]

    Final Report on the Implementation of the Task Force Recommendations U.S.-Canada Power System Outage Task Force Natural Resources Canada U.S. Department of Energy September 2006 Final Report on the Implementation of the Task Force Recommendations U.S.-Canada Power System Outage Task Force September 2006 Natural Resources Canada U.S. Department of Energy Acknowledgments This document was prepared by staff of Natural Resources Canada and the U.S. Department of Energy. The principal contributors

  3. Verification Monitoring Report

    Office of Legacy Management (LM)

    and Analytical Update for the Durango, Colorado, Processing Site August 2014 LMS/DUP/S11345 This page intentionally left blank LMS/DUP/S11345 Verification Monitoring Report and Analytical Update for the Durango, Colorado, Processing Site August 2014 This page intentionally left blank U.S. Department of Energy Verification Monitoring Report and Analytical Update-Durango, Colorado, Processing Site August 2014 Doc. No. S11345 Page i Contents Abbreviations

  4. Report to Congress on abnormal occurrences, January--March 1990

    SciTech Connect (OSTI)

    Not Available

    1990-07-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to Congress. This report covers the period from January 1 through March 31, 1990. for this reporting period, there were 10 abnormal occurrences. One involved the loss of vital ac power with a subsequent reactor coolant system heat-up at the Vogtle Unit 1 nuclear power plant during shutdown. The event was investigated by an NRC Incident Investigation Team (IIT). The other nine abnormal occurrences involved nuclear material licensees and are described in detail under other NRC-issued licenses: eight of these involved medical therapy misadministrations; the other involved the receipt of an unshielded radioactive source at Amersham Corporation in Burlington, Massachusetts. The latter event was also investigated by an NRC IIT. No abnormal occurrences were reported by the Agreement States. The report also contains information that updates a previously reported abnormal occurrence.

  5. Updated Reporting Requirement Checklists and Research Performance...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Reporting Requirement Checklists and Research Performance Progress Report (RPPR) Updated Reporting Requirement Checklists and Research Performance Progress Report (RPPR) Policy ...

  6. Carcinoma of the anal canal: Intensity modulated radiation therapy (IMRT) versus three-dimensional conformal radiation therapy (3DCRT)

    SciTech Connect (OSTI)

    Sale, Charlotte; Moloney, Phillip; Mathlum, Maitham

    2013-12-15

    Patients with anal canal carcinoma treated with standard conformal radiotherapy frequently experience severe acute and late toxicity reactions to the treatment area. Roohipour et al. (Dis Colon Rectum 2008; 51: 14753) stated a patient's tolerance of chemoradiation to be an important prediction of treatment success. A new intensity modulated radiation therapy (IMRT) technique for anal carcinoma cases has been developed at the Andrew Love Cancer Centre aimed at reducing radiation to surrounding healthy tissue. A same-subject repeated measures design was used for this study, where five anal carcinoma cases at the Andrew Love Cancer Centre were selected. Conformal and IMRT plans were generated and dosimetric evaluations were performed. Each plan was prescribed a total of 54 Gray (Gy) over a course of 30 fractions to the primary site. The IMRT plans resulted in improved dosimetry to the planning target volume (PTV) and reduction in radiation to the critical structures (bladder, external genitalia and femoral heads). Statistically there was no difference between the IMRT and conformal plans in the dose to the small and large bowel; however, the bowel IMRT dosevolume histogram (DVH) doses were consistently lower. The IMRT plans were superior to the conformal plans with improved dose conformity and reduced radiation to the surrounding healthy tissue. Anecdotally it was found that patients tolerated the IMRT treatment better than the three-dimensional (3D) conformal radiation therapy. This study describes and compares the planning techniques.

  7. Stereotactic Ablative Radiation Therapy as First Local Therapy for Lung Oligometastases From Colorectal Cancer: A Single-Institution Cohort Study

    SciTech Connect (OSTI)

    Filippi, Andrea Riccardo; Badellino, Serena; Ceccarelli, Manuela; Guarneri, Alessia; Franco, Pierfrancesco; Monagheddu, Chiara; Spadi, Rosella; Ragona, Riccardo; Racca, Patrizia; Ricardi, Umberto

    2015-03-01

    Purpose: To estimate stereotactic ablative radiation therapy (SABR) efficacy and its potential role as an alternative to surgery for the treatment of lung metastases from colorectal cancer. Methods and Materials: Forty consecutive patients who received SABR as first local therapy at the time of lung progression were included, from 2004 to 2014. The primary study endpoint was overall survival. Secondary endpoints were progression-free survival and safety. Results: A single nodule was treated in 26 patients (65%), 2 nodules in 10 patients (25%), 3 in 3 patients (7.5%), and 4 in 1 patient (2.5%), for a total of 59 lesions. The median delivered biological effective dose was 96 Gy, in 1 to 8 daily fractions. Median follow-up time was 20 months (range, 3-72 months). Overall survival rates at 1, 2, and 5 years were, respectively, 84%, 73%, and 39%, with 14 patients (35%) dead. Median overall survival was 46 months. Progression occurred in 25 patients (62.5%), at a median interval of 8 months; failure at SABR site was observed in 3 patients (7.5%). Progression-free survival rates were 49% and 27% at 1 and 2 years, respectively. Discussion: The results of this retrospective exploratory analysis suggest safety and efficacy of SABR in patients affected with colorectal cancer lung oligometastases and urge inclusion of SABR in prospective clinical trials.

  8. Heating Oil and Propane Update - Revision report

    Gasoline and Diesel Fuel Update (EIA)

    Revision reports Revision report 2015-2016 Revision report 2014-2015

  9. 2001 FEMP Customer Survey Report (Main Report) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Main Report) 2001 FEMP Customer Survey Report (Main Report) This summary presents the key findings and recommendations from the 2001 FEMP customer survey. The key findings presented in this summary are a condensed presentation of the more detailed findings presented in each of the chapters. PDF icon Study Report More Documents & Publications 2001 FEMP Customer Survey Report (Summary

  10. 2001 FEMP Customer Survey Report (Summary Report) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Summary Report) 2001 FEMP Customer Survey Report (Summary Report) The study was targeted to collect information from the average FEMP customer. As a result, the respondents in this survey represent 27 different federal agencies and a group of private contractors who have contracts with one or more federal agencies PDF icon Summary Report More Documents & Publications 2001 FEMP Customer Survey Report (Main

  11. Annual Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Annual Reports Annual Reports Annual Reports December 30, 2014 Southeastern Power Administration 2014 Annual Report This report reflects our agency's programs,accomplishments, operational, and financial activities for the 12-month period beginning October 1, 2013, and ending September 30, 2014. December 31, 2013 Southeastern Power Administration 2013 Annual Report This report reflects our agency's programs,accomplishments, operational, and financial activities for the 12-month period beginning

  12. Intraoperative Electron-Beam Radiation Therapy for Pediatric Ewing Sarcomas and Rhabdomyosarcomas: Long-Term Outcomes

    SciTech Connect (OSTI)

    Sole, Claudio V.; Calvo, Felipe A.; Polo, Alfredo; Cambeiro, Mauricio; Gonzalez, Carmen; Desco, Manuel; Martinez-Monge, Rafael

    2015-08-01

    Purpose: To assess long-term outcomes and toxicity of intraoperative electron-beam radiation therapy (IOERT) in the management of pediatric patients with Ewing sarcomas (EWS) and rhabdomyosarcomas (RMS). Methods and Materials: Seventy-one sarcoma (EWS n=37, 52%; RMS n=34, 48%) patients underwent IOERT for primary (n=46, 65%) or locally recurrent sarcomas (n=25, 35%) from May 1983 to November 2012. Local control (LC), overall survival (OS), and disease-free survival were estimated using Kaplan-Meier methods. For survival outcomes, potential associations were assessed in univariate and multivariate analyses using the Cox proportional hazards model. Results: After a median follow-up of 72 months (range, 4-310 months), 10-year LC, disease-free survival, and OS was 74%, 57%, and 68%, respectively. In multivariate analysis after adjustment for other covariates, disease status (P=.04 and P=.05) and R1 margin status (P<.01 and P=.04) remained significantly associated with LC and OS. Nine patients (13%) reported severe chronic toxicity events (all grade 3). Conclusions: A multimodal IOERT-containing approach is a well-tolerated component of treatment for pediatric EWS and RMS patients, allowing reduction or substitution of external beam radiation exposure while maintaining high local control rates.

  13. Library | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ICRU REPORT 58 c 19980504 024 Library of Congress Catalogingin-Publication Data Dose and volume specification for reporting interstitial therapy. p. "Issued: 1 August 1997." cm. - (ICRU report ; 58) Includes bibliographical references and index. 1. Radioisotope brachytherapy. 2. Radiation dosimety. ISBN 0-913394-57-2 I. International Commission on Radiation Units and Measurements. 11. Series. WN 250.5.B7 D722 19971 RA1231.R2155 no. 58 [RC271.R27] 616.07'57 A c 2 1 [615.8'4241 DNLM: 1.

  14. 2010 Site Environmental Report

    SciTech Connect (OSTI)

    Ratel, K.; Lee, R; Remien, J; Hooda, B; Green, T; Williams, J; Pohlot, P; Dorsch, W; Paquette, D; Burke, J

    2011-10-01

    Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy. The report is written to inform the public, regulators, employees, and other stakeholders of the Laboratory's environmental performance during the calendar year in review. Volume I of the SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and performance in restoration and surveillance monitoring programs. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. Volume II of the SER, the Groundwater Status Report, also is prepared annually to report on the status of and evaluate the performance of groundwater treatment systems at the Laboratory. Volume II includes detailed technical summaries of groundwater data and its interpretation, and is intended for internal BNL users, regulators, and other technically oriented stakeholders. A brief summary of the information contained in Volume II is included in Chapter 7, Groundwater Protection, of this volume. Both reports are available in print and as downloadable files on the BNL web page at http://www.bnl.gov/ewms/ser/. An electronic version on compact disc is distributed with each printed report. In addition, a summary of Volume I is prepared each year to provide a general overview of the report, and is distributed with a compact disc containing the full report. BNL is operated and managed for DOE's Office of Science by Brookhaven Science Associates (BSA), a partnership formed by Stony Brook University and Battelle Memorial Institute. For more than 60 years, the Laboratory has played a lead role in the DOE Science and Technology mission and continues to contribute to the DOE missions in energy resources, environmental quality, and national security. BNL manages its world-class scientific research with particular sensitivity to environmental issues and community concerns. The Laboratory's motto, 'Exploring Life's Mysteries...Protecting its Future,' and its Environmental, Safety, Security and Health Policy reflect the commitment of BNL's management to fully integrate environmental stewardship into all facets of its mission and operations.

  15. Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel

    SciTech Connect (OSTI)

    Baldini, Elizabeth H.; Wang, Dian; Haas, Rick L.M.; Catton, Charles N.; Indelicato, Daniel J.; Kirsch, David G.; Roberge, David; Salerno, Kilian; Deville, Curtiland; Guadagnolo, B. Ashleigh; O'Sullivan, Brian; Petersen, Ivy A.; Le Pechoux, Cecile; Abrams, Ross A.; DeLaney, Thomas F.

    2015-07-01

    Purpose: Evidence for external beam radiation therapy (RT) as part of treatment for retroperitoneal sarcoma (RPS) is limited. Preoperative RT is the subject of a current randomized trial, but the results will not be available for many years. In the meantime, many practitioners use preoperative RT for RPS, and although this approach is used in practice, there are no radiation treatment guidelines. An international expert panel was convened to develop consensus treatment guidelines for preoperative RT for RPS. Methods and Materials: An expert panel of 15 academic radiation oncologists who specialize in the treatment of sarcoma was assembled. A systematic review of reports related to RT for RPS, RT for extremity sarcoma, and RT-related toxicities for organs at risk was performed. Due to the paucity of high-quality published data on the subject of RT for RPS, consensus recommendations were based largely on expert opinion derived from clinical experience and extrapolation of relevant published reports. It is intended that these clinical practice guidelines be updated as pertinent data become available. Results: Treatment guidelines for preoperative RT for RPS are presented. Conclusions: An international panel of radiation oncologists who specialize in sarcoma reached consensus guidelines for preoperative RT for RPS. Many of the recommendations are based on expert opinion because of the absence of higher level evidence and, thus, are best regarded as preliminary. We emphasize that the role of preoperative RT for RPS has not been proven, and we await data from the European Organization for Research and Treatment of Cancer (EORTC) study of preoperative radiotherapy plus surgery versus surgery alone for patients with RPS. Further data are also anticipated pertaining to normal tissue dose constraints, particularly for bowel tolerance. Nonetheless, as we await these data, the guidelines herein can be used to establish treatment uniformity to aid future assessments of efficacy and toxicity.

  16. 2004 SITE ENVIRONMENTAL REPORT

    SciTech Connect (OSTI)

    BROOKHAVEN NATIONAL LABORATORY; SER TEAM; ENVIRONMENTAL INFORMATION MANAGEMENT SERVICES GROUP; ENVIROMENTAL AND WASTE MANAGEMENT SERVICES DIVISION FIELD SAMPLING TEAM

    2005-08-22

    Each year, Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy (DOE). The SER is written to inform the public, regulators, Laboratory employees, and other stakeholders of BNL's environmental performance during the calendar year in review. The report summarizes BNL's environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and restoration and surveillance monitoring programs. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. The SER is intended to be a technical document. It is available in print and as a downloadable file on the BNL web page at http://www.bnl.gov/esd/SER.htm. A summary of the SER is also prepared each year to provide a general overview of the report, and is distributed with a CD version of the full report. The summary supports BNL's educational and community outreach program.

  17. Technical progress report

    SciTech Connect (OSTI)

    1996-10-01

    This report summarizes experimental and theoretical work in basic nuclear physics carried out between October 1, 1995, the closing of our last Progress Report, and September 30, 1996 at the Nuclear Physics Laboratory of the University of Colorado, Boulder, under contracts DE-FG03-93ER-40774 and DE-FG03-95ER-40913 with the United States Department of Energy. The experimental contract supports broadly-based experimental research in intermediate energy nuclear physics. This report includes results from studies of Elementary Systems involving the study of the structure of the nucleon via polarized high-energy positron scattering (the HERMES experiment) and lower energy pion scattering from both polarized and unpolarized nucleon targets. Results from pion- and kaon-induced reactions in a variety of nuclear systems are reported under the section heading Meson Reactions; the impact of these and other results on understanding the nucleus is presented in the Nuclear Structure section. In addition, new results from scattering of high-energy electrons (from CEBAF/TJNAF) and pions (from KEK) from a broad range of nuclei are reported in the section on Incoherent Reactions. Finally, the development and performance of detectors produced by the laboratory are described in the section titled Instrumentation.

  18. International petroleum statistics report

    SciTech Connect (OSTI)

    1997-05-01

    The International Petroleum Statistics Report is a monthly publication that provides current international oil data. This report is published for the use of Members of Congress, Federal agencies, State agencies, industry, and the general public. Publication of this report is in keeping with responsibilities given the Energy Information Administration in Public Law 95-91. The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1985 through 1995.

  19. AAPM and GEC-ESTRO guidelines for image-guided robotic brachytherapy: Report of Task Group 192

    SciTech Connect (OSTI)

    Podder, Tarun K.; Beaulieu, Luc; Caldwell, Barrett; Cormack, Robert A.; Crass, Jostin B.; Dicker, Adam P.; Yu, Yan; Fenster, Aaron; Fichtinger, Gabor; Meltsner, Michael A.; Moerland, Marinus A.; Nath, Ravinder; Rivard, Mark J.; Salcudean, Tim; Song, Danny Y.; Thomadsen, Bruce R.

    2014-10-15

    In the last decade, there have been significant developments into integration of robots and automation tools with brachytherapy delivery systems. These systems aim to improve the current paradigm by executing higher precision and accuracy in seed placement, improving calculation of optimal seed locations, minimizing surgical trauma, and reducing radiation exposure to medical staff. Most of the applications of this technology have been in the implantation of seeds in patients with early-stage prostate cancer. Nevertheless, the techniques apply to any clinical site where interstitial brachytherapy is appropriate. In consideration of the rapid developments in this area, the American Association of Physicists in Medicine (AAPM) commissioned Task Group 192 to review the state-of-the-art in the field of robotic interstitial brachytherapy. This is a joint Task Group with the Groupe Europen de Curiethrapie-European Society for Radiotherapy and Oncology (GEC-ESTRO). All developed and reported robotic brachytherapy systems were reviewed. Commissioning and quality assurance procedures for the safe and consistent use of these systems are also provided. Manual seed placement techniques with a rigid template have an estimated in vivo accuracy of 36 mm. In addition to the placement accuracy, factors such as tissue deformation, needle deviation, and edema may result in a delivered dose distribution that differs from the preimplant or intraoperative plan. However, real-time needle tracking and seed identification for dynamic updating of dosimetry may improve the quality of seed implantation. The AAPM and GEC-ESTRO recommend that robotic systems should demonstrate a spatial accuracy of seed placement ?1.0 mm in a phantom. This recommendation is based on the current performance of existing robotic brachytherapy systems and propagation of uncertainties. During clinical commissioning, tests should be conducted to ensure that this level of accuracy is achieved. These tests should mimic the real operating procedure as closely as possible. Additional recommendations on robotic brachytherapy systems include display of the operational state; capability of manual override; documented policies for independent check and data verification; intuitive interface displaying the implantation plan and visualization of needle positions and seed locations relative to the target anatomy; needle insertion in a sequential order; robotclinician and robotpatient interactions robustness, reliability, and safety while delivering the correct dose at the correct site for the correct patient; avoidance of excessive force on radioactive sources; delivery confirmation of the required number or position of seeds; incorporation of a collision avoidance system; system cleaning, decontamination, and sterilization procedures. These recommendations are applicable to end users and manufacturers of robotic brachytherapy systems.

  20. Sandia National Laboratories: News: Publications: HPC Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HPC Annual Reports Annual Report Environmental Reports Fact Sheets Labs Accomplishments Lab News Partnerships Annual Report Research Magazine HPC Annual Reports Search Sandia Publications Strategic Plan News HPC Annual Reports 2015 Report HPC Annual Report 2015 HPC Annual Report (PDF, 9 MB) 2014 Report Environmental Report cover 2014 HPC Annual Report (PDF, 10 MB) 2013 Report HPC Annual Report cover 2013 HPC Annual Report (PDF, 6.12 MB)

  1. Proton Beam Therapy Versus Conformal Photon Radiation Therapy for Childhood Craniopharyngioma: Multi-institutional Analysis of Outcomes, Cyst Dynamics, and Toxicity

    SciTech Connect (OSTI)

    Bishop, Andrew J.; Greenfield, Brad; Mahajan, Anita; Paulino, Arnold C.; Okcu, M. Fatih; Allen, Pamela K.; Chintagumpala, Murali; Kahalley, Lisa S.; McAleer, Mary F.; McGovern, Susan L.; Whitehead, William E.; Grosshans, David R.

    2014-10-01

    Purpose: We compared proton beam therapy (PBT) with intensity modulated radiation therapy (IMRT) for pediatric craniopharyngioma in terms of disease control, cyst dynamics, and toxicity. Methods and Materials: We reviewed records from 52 children treated with PBT (n=21) or IMRT (n=31) at 2 institutions from 1996-2012. Endpoints were overall survival (OS), disease control, cyst dynamics, and toxicity. Results: At 59.6 months' median follow-up (PBT 33 mo vs IMRT 106 mo; P<.001), the 3-year outcomes were 96% for OS, 95% for nodular failure-free survival and 76% for cystic failure-free survival. Neither OS nor disease control differed between treatment groups (OS P=.742; nodular failure-free survival P=.546; cystic failure-free survival P=.994). During therapy, 40% of patients had cyst growth (20% requiring intervention); immediately after therapy, 17 patients (33%) had cyst growth (transient in 14), more commonly in the IMRT group (42% vs 19% PBT; P=.082); and 27% experienced late cyst growth (32% IMRT, 19% PBT; P=.353), with intervention required in 40%. Toxicity did not differ between groups. On multivariate analysis, cyst growth was related to visual and hypothalamic toxicity (P=.009 and .04, respectively). Patients given radiation as salvage therapy (for recurrence) rather than adjuvant therapy had higher rates of visual and endocrine (P=.017 and .024, respectively) dysfunction. Conclusions: Survival and disease-control outcomes were equivalent for PBT and IMRT. Cyst growth is common, unpredictable, and should be followed during and after therapy, because it contributes to late toxicity. Delaying radiation therapy until recurrence may result in worse visual and endocrine function.

  2. EIA-Voluntary Reporting of Greenhouse Gases Program - Why Report

    U.S. Energy Information Administration (EIA) Indexed Site

    Reporting of Greenhouse Gases Program Why Report What Is the Purpose of Form EIA-1605? Form EIA-1605 provides the means for the voluntary reporting of greenhouse gas emissions, ...

  3. Cyclotron Produced Radionuclides for Diagnosis and Therapy of Human Neoplasms

    SciTech Connect (OSTI)

    Steven Larson MD

    2009-09-21

    This project funded since 1986 serves as a core project for cancer research throughout MSKCC, producing key radiotracers as well as basic knowledge about thel physics of radiation decay and imaging, for nuclear medicine applications to cancer diagnosis and therapy. In recent years this research application has broadened to include experiments intended to lead to an improved understanding of cancer biology and into the discovery and testing of new cancer drugs. Advances in immune based radiotargeting form the basis for this project. Both antibody and cellular based immune targeting methods have been explored. The multi-step targeting methodologies (MST) developed by NeoRex (Seattle,Washington), have been adapted for use with positron emitting isotopes and PET allowing the quantification and optimization of targeted delivery. In addition, novel methods for radiolabeling immune T-cells with PET tracers have advanced our ability to track these cells of prolonged period of time.

  4. Delineation of Supraclavicular Target Volumes in Breast Cancer Radiation Therapy

    SciTech Connect (OSTI)

    Brown, Lindsay C.; Diehn, Felix E.; Boughey, Judy C.; Childs, Stephanie K.; Park, Sean S.; Yan, Elizabeth S.; Petersen, Ivy A.; Mutter, Robert W.

    2015-07-01

    Purpose: To map the location of gross supraclavicular metastases in patients with breast cancer, in order to determine areas at highest risk of harboring subclinical disease. Methods and Materials: Patients with axial imaging of gross supraclavicular disease were identified from an institutional breast cancer registry. Locations of the metastatic lymph nodes were transferred onto representative axial computed tomography images of the supraclavicular region and compared with the Radiation Therapy Oncology Group (RTOG) breast cancer atlas for radiation therapy planning. Results: Sixty-two patients with 161 supraclavicular nodal metastases were eligible for study inclusion. At the time of diagnosis, 117 nodal metastases were present in 44 patients. Forty-four nodal metastases in 18 patients were detected at disease recurrence, 4 of whom had received prior radiation to the supraclavicular fossa. Of the 161 nodal metastases, 95 (59%) were within the RTOG consensus volume, 4 nodal metastases (2%) in 3 patients were marginally within the volume, and 62 nodal metastases (39%) in 30 patients were outside the volume. Supraclavicular disease outside the RTOG consensus volume was located in 3 regions: at the level of the cricoid and thyroid cartilage (superior to the RTOG volume), in the posterolateral supraclavicular fossa (posterolateral to the RTOG volume), and in the lateral low supraclavicular fossa (lateral to the RTOG volume). Only women with multiple supraclavicular metastases had nodal disease that extended superiorly to the level of the thyroid cartilage. Conclusions: For women with risk of harboring subclinical supraclavicular disease warranting the addition of supraclavicular radiation, coverage of the posterior triangle and the lateral low supraclavicular region should be considered. For women with known supraclavicular disease, extension of neck coverage superior to the cricoid cartilage may be warranted.

  5. Measurements and simulations of focused beam for orthovoltage therapy

    SciTech Connect (OSTI)

    Abbas, Hassan; Mahato, Dip N.; Satti, Jahangir; MacDonald, C. A.

    2014-04-15

    Purpose: Megavoltage photon beams are typically used for therapy because of their skin-sparing effect. However, a focused low-energy x-ray beam would also be skin sparing, and would have a higher dose concentration at the focal spot. Such a beam can be produced with polycapillary optics. MCNP5 was used to model dose profiles for a scanned focused beam, using measured beam parameters. The potential of low energy focused x-ray beams for radiation therapy was assessed. Methods: A polycapillary optic was used to focus the x-ray beam from a tungsten source. The optic was characterized and measurements were performed at 50 kV. PMMA blocks of varying thicknesses were placed between optic and the focal spot to observe any variation in the focusing of the beam after passing through the tissue-equivalent material. The measured energy spectrum was used to model the focused beam in MCNP5. A source card (SDEF) in MCNP5 was used to simulate the converging x-ray beam. Dose calculations were performed inside a breast tissue phantom. Results: The measured focal spot size for the polycapillary optic was 0.2 mm with a depth of field of 5 mm. The measured focal spot remained unchanged through 40 mm of phantom thickness. The calculated depth dose curve inside the breast tissue showed a dose peak several centimeters below the skin with a sharp dose fall off around the focus. The percent dose falls below 10% within 5 mm of the focus. It was shown that rotating the optic during scanning would preserve the skin-sparing effect of the focused beam. Conclusions: Low energy focused x-ray beams could be used to irradiate tumors inside soft tissue within 5 cm of the surface.

  6. Dosimetrically Triggered Adaptive Intensity Modulated Radiation Therapy for Cervical Cancer

    SciTech Connect (OSTI)

    Lim, Karen; Stewart, James; Kelly, Valerie; Xie, Jason; Brock, Kristy K.; Moseley, Joanne; Cho, Young-Bin; Fyles, Anthony; Lundin, Anna; Rehbinder, Henrik; Lf, Johan; Jaffray, David A.; Milosevic, Michael

    2014-09-01

    Purpose: The widespread use of intensity modulated radiation therapy (IMRT) for cervical cancer has been limited by internal target and normal tissue motion. Such motion increases the risk of underdosing the target, especially as planning margins are reduced in an effort to reduce toxicity. This study explored 2 adaptive strategies to mitigate this risk and proposes a new, automated method that minimizes replanning workload. Methods and Materials: Thirty patients with cervical cancer participated in a prospective clinical study and underwent pretreatment and weekly magnetic resonance (MR) scans over a 5-week course of daily external beam radiation therapy. Target volumes and organs at risk (OARs) were contoured on each of the scans. Deformable image registration was used to model the accumulated dose (the real dose delivered to the target and OARs) for 2 adaptive replanning scenarios that assumed a very small PTV margin of only 3mm to account for setup and internal interfractional motion: (1)a preprogrammed, anatomy-driven midtreatment replan (A-IMRT); and (2) a dosimetry-triggered replan driven by target dose accumulation over time (D-IMRT). Results: Across all 30 patients, clinically relevant target dose thresholds failed for 8 patients (27%) if 3-mm margins were used without replanning. A-IMRT failed in only 3 patients and also yielded an additional small reduction in OAR doses at the cost of 30 replans. D-IMRT assured adequate target coverage in all patients, with only 23 replans in 16 patients. Conclusions: A novel, dosimetry-triggered adaptive IMRT strategy for patients with cervical cancer can minimize the risk of target underdosing in the setting of very small margins and substantial interfractional motion while minimizing programmatic workload and cost.

  7. Beam director design report

    SciTech Connect (OSTI)

    Younger, F.C.

    1986-08-01

    A design and fabrication effort for a beam director is documented. The conceptual design provides for the beam to pass first through a bending and focusing system (or ''achromat''), through a second achromat, through an air-to-vacuum interface (the ''beam window''), and finally through the vernier steering system. Following an initial concept study for a beam director, a prototype permanent magnet 30/sup 0/ beam-bending achromat and prototype vernier steering magnet were designed and built. In volume II, copies are included of the funding instruments, requests for quotations, purchase orders, a complete set of as-built drawings, magnetic measurement reports, the concept design report, and the final report on the design and fabrication project. (LEW)

  8. Final Technical Report

    SciTech Connect (OSTI)

    Maxwell, Mike, J., P.E.

    2012-08-30

    The STI product is the Final Technical Report from ReliOn, Inc. for contract award DE-EE0000487: Recovery Act PEM Fuel Cell Systems Providing Emergency Reserve and Backup Power. The program covered the turnkey deployment of 431 ReliOn fuel cell systems at 189 individual sites for AT&T and PG&E with ReliOn functioning as the primary equipment supplier and the project manager. The Final Technical Report provides an executive level summary, a comparison of the actual accomplishments vs. the goals and objectives of the project, as well as a summary of the project activity from the contract award date of August 1, 2009 through the contract expiration date of December 31, 2011. Two photos are included in the body of the report which show hydrogen storage and bulk hydrogen refueling technologies developed as a result of this program.

  9. LNG Annual Report - 2006 | Department of Energy

    Energy Savers [EERE]

    6 LNG Annual Report - 2006 LNG Annual Report - 2006 PDF icon LNG Annual Report - 2006 More Documents & Publications LNG Annual Report - 2007 LNG Annual Report - 2008

  10. LNG Annual Report - 2010 | Department of Energy

    Energy Savers [EERE]

    10 LNG Annual Report - 2010 LNG Annual Report - 2010 PDF icon LNG Annual Report - 2010 More Documents & Publications LNG Annual Report - 2009 LNG Annual Report - 2008

  11. DOE - Office of Legacy Management -- Fernald Reports

    Office of Legacy Management (LM)

    Inspection Reports Combined Site and OSDF Inspection Report December 2015 Inspection Report September 2015 Inspection Report June 2015 Inspection Report March 2015 Inspection ...

  12. OHA 2008 ANNUAL REPORT | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    8 ANNUAL REPORT OHA 2008 ANNUAL REPORT PDF icon OHA 2008 ANNUAL REPORT FINAL More Documents & Publications OHA 2007 ANNUAL REPORT OHA 2009 ANNUAL REPORT OHA 2015

  13. LNG Monthly Report - 2015 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Monthly Report - 2015 LNG Monthly Report - 2015 LNG Monthly Report - 2015 PDF icon LNG 2015.pdf More Documents & Publications LNG Annual Report - 2014 LNG Annual Report - 2013

  14. ALCC Allocation Final Report: HPC Colony II (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    ALCC Allocation Final Report: HPC Colony II Citation Details In-Document Search Title: ALCC Allocation Final Report: HPC Colony II You are accessing a document from the ...

  15. Anonymous Referee Report (Technical Report) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Anonymous Referee Report Citation Details In-Document Search Title: ... This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and ...

  16. An Anonymous Referee Report (Technical Report) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Technical Report: An Anonymous Referee Report Citation Details In-Document Search Title: ... This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and ...

  17. Direct Fast-Neutron Detection: A Progress Report (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Direct Fast-Neutron Detection: A Progress Report Citation Details ... Visit OSTI to utilize additional information resources in energy science and technology. A ...

  18. DNDO Report (Technical Report) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    DNDO Report Citation Details In-Document Search Title: DNDO Report My internship program ... Save Share this Record Citation Formats MLA APA Chicago Bibtex Export Metadata Endnote ...

  19. Reporting Guidance for Federal Agency Annual Report on Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Guidance includes three attachments that were developed to assist agencies with their reporting requirements. Open the reporting requirements template to access: Attachment 1: ...

  20. Long Range Neutron Detection: A Progress Report (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Long Range Neutron Detection: A Progress Report Citation Details In-Document Search Title: Long Range Neutron Detection: A Progress Report You are accessing a document from the ...

  1. Long Range Neutron Detection: A Progress Report (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Long Range Neutron Detection: A Progress Report Citation Details In-Document Search Title: Long Range Neutron Detection: A Progress Report The detection of neutron sources horn a ...

  2. Drum drop test report

    SciTech Connect (OSTI)

    McBeath, R.S.

    1995-02-28

    Testing was performed to determine actual damage to drums when dropped from higher than currently stacked elevations. The drum configurations were the same as they are placed in storage; single drums and four drums banded to a pallet. Maximum drop weights were selected based on successful preliminary tests. Material was lost from each of the single drum tests while only a small amount of material was lost from one of the pelletized drums. The test results are presented in this report. This report also provides recommendations for further testing to determine the appropriate drum weight which can be stored on a fourth tier.

  3. SPEAR 3 Quarterly Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    through December 2000 TABLE OF CONTENTS A. Project Summary 1. Technical Progress 2. Cost Reporting B. Detailed Reports 1.1 Magnets & Supports 1.2 Vacuum System 1.3 Power Supplies 1.4 RF System 1.5 Instrumentation & Controls 1.6 Cable Plant 1.8 Facilities 2.1 Accelerator Physics 2.2 Environmental Health and Safety A. SPEAR 3 PROJECT SUMMARY 1. Technical Progress Some staff changes have occurred during this quarter as shown in the organization chart (Fig. A1). The Project Management

  4. SPEAR3 Quarterly Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    April through June 2000 TABLE OF CONTENTS A. Project Summary 1. Technical Progress 2. Cost Reporting B. Detailed Reports 1.1 Magnets & Supports 1.2 Vacuum System 1.3 Power Supplies 1.4 RF System 1.5 Instrumentation & Controls 1.6 Cable Plant 1.8 Facilities 2.1 Accelerator Physics 2.2 Environmental Safety & Health A. SPEAR 3 PROJECT SUMMARY 1. Technical Progress On June 13-14, 2000, a DOE (Lehman) review committee conducted the third construction management review of the SPEAR 3

  5. PPPL Site Environmental Report

    SciTech Connect (OSTI)

    Virginia Finley, Robeert Sheneman and Jerry Levine

    2012-12-21

    Contained in the following report are data for radioactivity in the environment collected and analyzed by Princeton Plasma Physics Laboratorys Princeton Environmental, Analytical, and Radiological Laboratory (PEARL). The PEARL is located on?site and is certified for analyzing radiological and non?radiological parameters through the New Jersey Department of Environmental Protections Laboratory Certification Program, Certification Number 12471. Non?radiological surface and ground water samples are analyzed by NJDEP certified subcontractor laboratories QC, Inc. and Accutest Laboratory. To the best of our knowledge, these data, as contained in the Annual Site Environmental Report for 2011, are documented and certified to be correct.

  6. Waste management progress report

    SciTech Connect (OSTI)

    1997-06-01

    During the Cold War era, when DOE and its predecessor agencies produced nuclear weapons and components, and conducted nuclear research, a variety of wastes were generated (both radioactive and hazardous). DOE now has the task of managing these wastes so that they are not a threat to human health and the environment. This document is the Waste Management Progress Report for the U.S. Department of Energy dated June 1997. This progress report contains a radioactive and hazardous waste inventory and waste management program mission, a section describing progress toward mission completion, mid-year 1997 accomplishments, and the future outlook for waste management.

  7. Report2003.doc

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2003 Annual Report I. Basic Information Regarding Report. A. Abel Lopez, Director FOIA/Privacy Act Group, ME-73 Office of the Executive Secretariat U.S. Department of Energy 1000 Independence Avenue, SW Washington, DC 20585 202-586-5955 Sandi Beatty, Information Specialist FOIA/Privacy Act Group, ME-73 Office of the Executive Secretariat U.S. Department of Energy 1000 Independence Avenue, SW Washington, DC 20585 202-586-5955 B. The World Wide Web address to obtain an electronic copy of the

  8. TANK SPACE OPTIONS REPORT

    SciTech Connect (OSTI)

    WILLIS WL; AHRENDT MR

    2009-08-11

    Since this report was originally issued in 2001, several options proposed for increasing double-shell tank (DST) storage space were implemented or are in the process of implementation. Changes to the single-shell tank (SST) waste retrieval schedule, completion of DST space saving options, and the DST space saving options in progress have delayed the projected shortfall of DST storage space from the 2007-2011 to the 2018-2025 timeframe (ORP-11242, River Protection Project System Plan). This report reevaluates options from Rev. 0 and includes evaluations of new options for alleviating projected restrictions on SST waste retrieval beginning in 2018 because of the lack of DST storage space.

  9. Nuclear Innovation Workshops Report

    SciTech Connect (OSTI)

    Jackson, John Howard; Allen, Todd Randall; Hildebrandt, Philip Clay; Baker, Suzanne Hobbs

    2015-09-01

    The Nuclear Innovation Workshops were held at six locations across the United States on March 3-5, 2015. The data collected during these workshops has been analyzed and sorted to bring out consistent themes toward enhancing innovation in nuclear energy. These themes include development of a test bed and demonstration platform, improved regulatory processes, improved communications, and increased public-private partnerships. This report contains a discussion of the workshops and resulting themes. Actionable steps are suggested at the end of the report. This revision has a small amount of the data in Appendix C removed in order to avoid potential confusion.

  10. Arundo Donax Analysis Report

    SciTech Connect (OSTI)

    Corrie I. Nichol, Ph.D.; Tyler L. Westover, Ph.D.

    2012-01-01

    This is a summary report of preliminary analysis conducted on Arundo Donax. Arundo Donax was received from Greenwood Resources via Portland General Electric. PGE plans to transition a coal-fired boiler to 100% biomass by 2020, and has partnered with EPRI and INL to conduct the necessary testing and development to understand what needs to take place to make this transition. Arundo Donax is a promising energy crop for biopower, and is as yet relatively untested and uncharacterized. The INL has begun initial characterization of this material, and this summary report presents the initial findings.

  11. Site Environmental Report, 1993

    SciTech Connect (OSTI)

    Not Available

    1994-06-01

    The Site Environmental Report (SER) is prepared annually in accordance with DOE Order 5400.1, ``General Environmental Protection Program.`` This 1993 SER provides the general public as well as scientists and engineers with the results from the site`s ongoing Environmental Monitoring Program. Also included in this report is information concerning the site`s progress toward achieving full compliance with requirements set forth by DOE, US Environmental Protection Agency (USEPA), and Ohio EPA (OEPA). For some readers, the highlights provided in the Executive Summary may provide sufficient information. Many readers, however, may wish to read more detailed descriptions of the information than those which are presented here.

  12. HPC Workshop Reports

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HPSS in the Extreme Scale Era (2018-2022): Report of the Extreme Scale Workshop July 15, 2009 | Download File: HPSSExtremeScaleFINALpublic.pdf | pdf | 1.6 MB This paper, from a workshop held at the National Energy Research Scientific Computing (NERSC) Facility in Oakland, CA, on July 14-15, 2009, is a report on the feasibility of using HPSS into the Extreme Scale era of storage (2018 - 2022). Workshop Participants: Danny Cook, LANL; Jason Hick, LBNL (chair); Jim Minton, LLNL; Henry Newman,

  13. An Inupiat Weather Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    An Iñupiat Weather Report Grades: 6 th - 8 th Duration: 2-3 hours of class time. Time for students to prepare their reports: 1 week. Objectives: The objective of this lesson is for students to correctly use the Iñupiat language using weather related vocabulary, numbers, and days of the week. Students will prepare a weather forecast and present it as if they were on a television news program. The forecast must be entirely in the Iñupiat language. Alaska State Content Standards:

  14. Annual Site Environmental Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Annual Site Environmental Report - 2002 Annual Site Environmental Report - 2002 DOE/NV11718--842 Prepared by Bechtel Nevada Post Office Box 98521 Las Vegas, NV 89193-8521 Prepared by Bechtel Nevada Post Office Box 98521 Las Vegas, NV 89193-8521 Prepared for the U.S. Department of Energy National Nuclear Security Administration Nevada Site Office Contract Number DE-AC08-96NV11718 Prepared for the U.S. Department of Energy National Nuclear Security Administration Nevada Site Office Contract Number

  15. Postmastectomy Hypofractionated and Accelerated Radiation Therapy With (and Without) Subcutaneous Amifostine Cytoprotection

    SciTech Connect (OSTI)

    Koukourakis, Michael I.

    2013-01-01

    Purpose: Postmastectomy radiation therapy (PMRT) provides major local control and survival benefits. More aggressive radiation therapy schemes may, however, be necessary in specific subgroups, provided they are safely administered. We report the tolerance and efficacy of a highly accelerated and hypofractionated regimen (HypoARC). Methods and Materials: One hundred twelve high-risk patients who had undergone mastectomy received 10 consecutive fractions of 3.5 Gy in 12 days (thoracic wall and axillary/supraclavicular areas). Two consecutive additional fractions of 4 Gy were given to the surgical scar area (electrons 8-10 MeV) and 1 3.5-Gy fraction to the axilla (in cases with extensive nodal involvement). A minimum follow-up of 24 months (median, 44 months) was allowed before analysis. Of 112 patients, 21 (18.7%) refused to receive amifostine, the remaining receiving tolerance-based individualized doses (500-1000 mg/day subcutaneously). Results: By use of a dose individualization algorithm, 68.1%, 11%, and 18.7% of patients received 1000 mg, 750 mg, and 500 mg/day of amifostine. Patchy moist skin desquamation outside and inside the booster fields was noted in 14 of 112 (12.5%) and 26 of 112 (23.2%) patients, respectively. No case of acute pneumonitis was recorded. High amifostine dose offered a significant skin protection. Within a median follow-up time of 44 months, moderate subcutaneous edema outside and within the booster thoracic area was noted in 5 of 112 (4.4%) and 8 of 112 (7.1%) cases, respectively. Intense asymptomatic radiographic findings of in field lung fibrosis were noted in 4 of 112 (3.6%) patients. Amifostine showed a significant protection against lung and soft tissue fibrosis. A 97% projected 5-year local relapse free survival and 84% 5-year disease-specific survival were recorded. Lack of steroid receptor expression, simple human epidermal growth factor 2 positivity, or triple negative phenotype defined higher metastasis rates but had no effect on local control. Conclusions: PMRT with HypoARC showed an excellent early and short-term late toxicity profile, and amifostine further reduced early and late radiation sequelae. Encouraging local control rates are obtained in high-risk subgroups.

  16. Design and implementation of a water phantom for IMRT, arc therapy, and tomotherapy dose distribution measurements

    SciTech Connect (OSTI)

    Pallotta, Stefania; Marrazzo, Livia; Bucciolini, Marta

    2007-10-15

    The aim of this paper is to present a new phantom for arc therapy, intensity-modulated radiation therapy (IMRT), and tomotherapy dose distribution measurement in pretreatment verification. The presented phantom is innovative for its use of water as the tissue equivalent material, together with a technical solution specifically designed to support radiographic or radiochromic film and ionization chambers in any desired position. The phantom comprise a Plexiglas container, whose present shape and dimensions offer the possibility to simulate a human torso or abdomen; the container can be filled with water by opening the upper cover. On the internal side of the cover, a set of carbon pipes can support film in the desired coronal, axial, or sagittal planes. At one of the two ends of the phantom, an ionization chamber can be positioned parallel to the rotation axis of the accelerator gantry in all possible positions within a 20 cm diameter cylinder, for film calibration purposes. Inhomogeneities can be inserted into the phantom using the same carbon pipes and plastic sheets used to support film. An example of vertebra-shaped inserts made of bone equivalent material is reported. Radiochromic film can be dipped in water, while radiographic film must be protected to prevent damage. To accomplish this, radiographic film is laminated using a cold laminating film. In order to assess the effects of both the lamination itself and the effects of water on laminated Kodak EDR2 film, the optical density (OD) of conventional, laminated, and laminated film immersed in water and exposed to a range of doses from 0 to 300 cGy were compared. The OD of the three samples receiving the same radiation dose did not present any significant difference, thus proving that laminated EDR2 film can also be used in water. A prerequisite for any dosimetric comparison between planned and measured data is a proper film to plan registration. The solution proposed here is an extrinsic in-plane registration technique using four reference points marked on each film in predefined positions. The four points and the millimeter scales fixed on the carbon pipes that support the film are designed and manufactured so as to transfer onto the film the same reference system used during the planning procedure, thus allowing a straightforward registration. Tests to assess the accuracy of the proposed registration method demonstrate that the distances between measured and intended marker positions, evaluated for coronal, axial, and sagittal planes, were about 1 mm for both anteroposterior and lateral projections.

  17. An Easy Tool to Predict Survival in Patients Receiving Radiation Therapy for Painful Bone Metastases

    SciTech Connect (OSTI)

    Westhoff, Paulien G.; Graeff, Alexander de; Monninkhof, Evelyn M.; Bollen, Laurens; Dijkstra, Sander P.; Steen-Banasik, Elzbieta M. van der; Vulpen, Marco van; Leer, Jan Willem H.; Marijnen, Corrie A.; Linden, Yvette M. van der

    2014-11-15

    Purpose: Patients with bone metastases have a widely varying survival. A reliable estimation of survival is needed for appropriate treatment strategies. Our goal was to assess the value of simple prognostic factors, namely, patient and tumor characteristics, Karnofsky performance status (KPS), and patient-reported scores of pain and quality of life, to predict survival in patients with painful bone metastases. Methods and Materials: In the Dutch Bone Metastasis Study, 1157 patients were treated with radiation therapy for painful bone metastases. At randomization, physicians determined the KPS; patients rated general health on a visual analogue scale (VAS-gh), valuation of life on a verbal rating scale (VRS-vl) and pain intensity. To assess the predictive value of the variables, we used multivariate Cox proportional hazard analyses and C-statistics for discriminative value. Of the final model, calibration was assessed. External validation was performed on a dataset of 934 patients who were treated with radiation therapy for vertebral metastases. Results: Patients had mainly breast (39%), prostate (23%), or lung cancer (25%). After a maximum of 142 weeks' follow-up, 74% of patients had died. The best predictive model included sex, primary tumor, visceral metastases, KPS, VAS-gh, and VRS-vl (C-statistic = 0.72, 95% CI = 0.70-0.74). A reduced model, with only KPS and primary tumor, showed comparable discriminative capacity (C-statistic = 0.71, 95% CI = 0.69-0.72). External validation showed a C-statistic of 0.72 (95% CI = 0.70-0.73). Calibration of the derivation and the validation dataset showed underestimation of survival. Conclusion: In predicting survival in patients with painful bone metastases, KPS combined with primary tumor was comparable to a more complex model. Considering the amount of variables in complex models and the additional burden on patients, the simple model is preferred for daily use. In addition, a risk table for survival is provided.

  18. MO-G-BRE-09: Validating FMEA Against Incident Learning Data: A Study in Stereotactic Body Radiation Therapy

    SciTech Connect (OSTI)

    Yang, F; Cao, N; Young, L; Howard, J; Sponseller, P; Logan, W; Arbuckle, T; Korssjoen, T; Meyer, J; Ford, E

    2014-06-15

    Purpose: Though FMEA (Failure Mode and Effects Analysis) is becoming more widely adopted for risk assessment in radiation therapy, to our knowledge it has never been validated against actual incident learning data. The objective of this study was to perform an FMEA analysis of an SBRT (Stereotactic Body Radiation Therapy) treatment planning process and validate this against data recorded within an incident learning system. Methods: FMEA on the SBRT treatment planning process was carried out by a multidisciplinary group including radiation oncologists, medical physicists, and dosimetrists. Potential failure modes were identified through a systematic review of the workflow process. Failure modes were rated for severity, occurrence, and detectability on a scale of 1 to 10 and RPN (Risk Priority Number) was computed. Failure modes were then compared with historical reports identified as relevant to SBRT planning within a departmental incident learning system that had been active for two years. Differences were identified. Results: FMEA identified 63 failure modes. RPN values for the top 25% of failure modes ranged from 60 to 336. Analysis of the incident learning database identified 33 reported near-miss events related to SBRT planning. FMEA failed to anticipate 13 of these events, among which 3 were registered with severity ratings of severe or critical in the incident learning system. Combining both methods yielded a total of 76 failure modes, and when scored for RPN the 13 events missed by FMEA ranked within the middle half of all failure modes. Conclusion: FMEA, though valuable, is subject to certain limitations, among them the limited ability to anticipate all potential errors for a given process. This FMEA exercise failed to identify a significant number of possible errors (17%). Integration of FMEA with retrospective incident data may be able to render an improved overview of risks within a process.

  19. Five-year Results of Whole Breast Intensity Modulated Radiation Therapy for the Treatment of Early Stage Breast Cancer: The Fox Chase Cancer Center Experience

    SciTech Connect (OSTI)

    Keller, Lanea M.M.; Sopka, Dennis M.; Li Tianyu; Klayton, Tracy; Li Jinsheng; Anderson, Penny R.; Bleicher, Richard J.; Sigurdson, Elin R.; Freedman, Gary M.

    2012-11-15

    Purpose: To report the 5-year outcomes using whole-breast intensity-modulated radiation therapy (IMRT) for the treatment of early-stage-breast cancer at the Fox Chase Cancer Center. Methods and Materials: A total of 946 women with early-stage breast cancer (stage 0, I, or II) were treated with IMRT after surgery with or without systemic therapy from 2003-2010. Whole-breast radiation was delivered via an IMRT technique with a median whole-breast radiation dose of 46 Gy and median tumor bed boost of 14 Gy. Endpoints included local-regional recurrence, cosmesis, and late complications. Results: With a median follow-up of 31 months (range, 1-97 months), there were 12 ipsilateral breast tumor recurrences (IBTR) and one locoregional recurrence. The 5-year actuarial IBTR and locoregional recurrence rates were 2.0% and 2.4%. Physician-reported cosmestic outcomes were available for 645 patients: 63% were considered 'excellent', 33% 'good', and <1.5% 'fair/poor'. For physician-reported cosmesis, boost doses {>=}16 Gy, breast size >900 cc, or boost volumes >34 cc were significantly associated with a 'fair/poor' cosmetic outcome. Fibrosis, edema, erythema, and telangectasia were also associated with 'fair/poor' physician-reported cosmesis; erythema and telangectasia remained significant on multivariate analysis. Patient-reported cosmesis was available for 548 patients, and 33%, 50%, and 17% of patients reported 'excellent', 'good', and 'fair/poor' cosmesis, respectively. The use of a boost and increased boost volume: breast volume ratio were significantly associated with 'fair/poor' outcomes. No parameter for patient-reported cosmesis was significant on multivariate analysis. The chances of experiencing a treatment related effect was significantly associated with a boost dose {>=}16 Gy, receipt of chemotherapy and endocrine therapy, large breast size, and electron boost energy. Conclusions: Whole-breast IMRT is associated with very low rates of local recurrence at 5 years, 83%-98% 'good/excellent' cosmetic outcomes, and minimal chronic toxicity, including late fibrosis.

  20. Annual Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Note: Some of the following documents are in PDF and will require Adobe Reader for viewing. Freedom of Information Act Annual Reports Annual Report for 2015 Annual Report for 2014 ...

  1. Energy Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Reports Energy Reports August 26, 2013 Audit Report: DOE/IG-0892 The Department of Energy's Administration of Energy Savings Performance Contract Biomass Projects July 9, 2013 INSPECTION REPORT: INS-L-13-05 Follow-up Inspection on Characterization Wells at Los Alamos National Laboratory June 19, 2013 Audit Report: OAS-RA-13-26 Department of Energy's Interconnection Transmission Planning Program Funded through the American Recovery and Reinvestment Act of 2009 June 18, 2013 Audit Report:

  2. LNG Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    LNG Reports LNG Reports May 13, 2016 LNG Monthly 2016 February 12, 2016 LNG Annual Report - 2015 LNG Annual Report - 2015 June 17, 2015 LNG Annual Report - 2014 LNG Annual Report - 2014 May 28, 2015 Order 3643: Alaska LNG Project, LLC This is the order authorizing Alaska LNG Project, LLC to export Liquefied Natural Gas (LNG) to non-FTA countries. May 12, 2015 Order 3638: Corpus Christi Liquefaction Project This is the order authorizing the Corpus Christi Liquefaction Project to export Liquefied

  3. Nomograms Predicting Response to Therapy and Outcomes After Bladder-Preserving Trimodality Therapy for Muscle-Invasive Bladder Cancer

    SciTech Connect (OSTI)

    Coen, John J.; Paly, Jonathan J.; Niemierko, Andrzej; Kaufman, Donald S.; Heney, Niall M.; Spiegel, Daphne Y.; Efstathiou, Jason A.; Zietman, Anthony L.; Shipley, William U.

    2013-06-01

    Purpose: Selective bladder preservation by use of trimodality therapy is an established management strategy for muscle-invasive bladder cancer. Individual disease features have been associated with response to therapy, likelihood of bladder preservation, and disease-free survival. We developed prognostic nomograms to predict the complete response rate, disease-specific survival, and likelihood of remaining free of recurrent bladder cancer or cystectomy. Methods and Materials: From 1986 to 2009, 325 patients were managed with selective bladder preservation at Massachusetts General Hospital (MGH) and had complete data adequate for nomogram development. Treatment consisted of a transurethral resection of bladder tumor followed by split-course chemoradiation. Patients with a complete response at midtreatment cystoscopic assessment completed radiation, whereas those with a lesser response underwent a prompt cystectomy. Prognostic nomograms were constructed predicting complete response (CR), disease-specific survival (DSS), and bladder-intact disease-free survival (BI-DFS). BI-DFS was defined as the absence of local invasive or regional recurrence, distant metastasis, bladder cancer-related death, or radical cystectomy. Results: The final nomograms included information on clinical T stage, presence of hydronephrosis, whether a visibly complete transurethral resection of bladder tumor was performed, age, sex, and tumor grade. The predictive accuracy of these nomograms was assessed. For complete response, the area under the receiving operating characteristic curve was 0.69. The Harrell concordance index was 0.61 for both DSS and BI-DFS. Conclusions: Our nomograms allow individualized estimates of complete response, DSS, and BI-DFS. They may assist patients and clinicians making important treatment decisions.

  4. Hydropower annual report 2003

    SciTech Connect (OSTI)

    Cada, Glenn F.; Carlson, Thomas J.; Dauble, Dennis D.; Hunt, Richard T.; Sale, Michael J.; Sommers, Garold L.

    2004-02-01

    This report describes hydropower activities supported by the U.S. Department of Energy (DOE) Wind and Hydropower Program during Fiscal Year 2003 (October 1, 2002 to September 30, 2003). Background on the program, FY03 accomplishments, and future plans are presented in the following sections.

  5. Energy, Data Management, Reporting

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Design the Strategy | Deliver Efficiency | Sustain Results Energy, Data Management, Reporting This presentation does not contain any proprietary, confidential, or otherwise restricted information. - - Agenda ● About Schneider Electric ● Enterprise wide Data Management ● Outputs ● Foundation and results ● Part of a complete energy management solution Schneider Electric Sustainability Services 2014 2 - - Schneider Electric Sustainability Services 2014 3 Schneider Electric - the global

  6. Sensors and Controls Reports

    Broader source: Energy.gov [DOE]

    Reports from the sensors, controls, and transactional network program. The transactional network is between appliances, buildings, and utilities, and can enable Smart Buildings -- buildings with technologies and control systems that can not only optimize energy performance and comfort, but also support energy-related transactions outside the building envelope.

  7. FY 2005 LDRD Report

    Broader source: Energy.gov [DOE]

    The multi-program national laboratories included in this report devoted approximately $384 million to LDRD, funding projects ranging in size from less than $5,000 per year to over $3 million, addressing topics that span the entire range of DOE's broad specific mandate.

  8. FY 2007 LDRD Report

    Broader source: Energy.gov [DOE]

    The multi-program national laboratories included in this report devoted approximately $499 million to LDRD, funding projects ranging in size from less than $5,000 per year to over $3 million, addressing topics that span the entire range of DOE’s broad scientific mandate.

  9. FY 2006 LDRD Report

    Broader source: Energy.gov [DOE]

    The multi-program national laboratories included in this report devoted approximately $476 million to LDRD, funding projects ranging in size from less than $5,000 per year to over $3 million, addressing topics that span the entire range of DOE’s broad scientific mandate.

  10. JPRS report proliferation issues

    SciTech Connect (OSTI)

    1991-11-18

    This report contains foreign media information on issues related to worldwide proliferation and transfer activities in nuclear, chemical, and biological weapons, including delivery systems and the transfer of weapons relevant technologies. The following locations are included: (1) China; (2) Indonesia; (3) Bulgaria; (4) Brazil, Cuba; (5) Egypt, India, Iran, Iraq, Israel, Pakistan; (6) Soviet Union; and (7) France, Germany, United Kingdom, Italy, Norway.

  11. IG-0704 Report Cover

    Energy Savers [EERE]

    U.S. Department of Energy Office of Inspector General Office of Audit Services The Federal Energy Regulatory Commission's Unclassified Cyber Security Program-2005 DOE/IG-0704 October 2005 REPORT ON THE FEDERAL ENERGY REGULATORY COMMISSION'S UNCLASSIFIED CYBER SECURITY PROGRAM - 2005 TABLE OF CONTENTS Cyber Security Program Details of Finding ..........................................................................................................1 Recommendations and

  12. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Aug-12 Sep-12 Oct-12 Nov-12 Dec-12 Jan-13 Feb-13 ... 4.01 3.89 4.02 4.12 4.22 First Aid Monthly First Aid 12-Month Average FY ... Performance Report JUL 2013 DOERL-2009-113 Rev 46 ...

  13. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... 40,410 25,835 14,574 3,922 RL-0041 B Reactor 8,288 ... hours that require more than first aid and must be reported. ... Sep-10 Oct-10 Nov-10 Dec-10 Jan-11 Feb-11 Mar-11 Apr-11 ...

  14. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... 0.0 22.4 0.0 22.4 RL-0040 Reliability ... 77 11 Table 3-4. First Aid Case Rate MSC Monthly Performance Report FEB 2016 DOERL-2009-113 ... the baseline for FY 2013, FY 2014, FY 2015, ...

  15. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... days or through January 22, 2015. SWS - 17.8 working ... first aid and must be reported. DOEEM Goal for FY 2015 is 1.1 0.00 0.50 1.00 1.50 2.00 2.50 3.00 Dec-13 Jan-14 Feb-14 ...

  16. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Jan-13 Feb-13 Mar-13 Apr-13 May-13 Jun-13 ... 3.89 4.02 4.12 4.22 4.27 4.52 4.40 4.74 4.87 First Aid Monthly First Aid 12-Month ... Report DEC 2013 DOERL-2009-113 Rev ...

  17. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Dec-12 Jan-13 Feb-13 Mar-13 Apr-13 May-13 ... 3.89 4.02 4.12 4.22 4.27 4.52 4.40 4.79 First Aid Monthly First Aid 12-Month Average ... Report NOV 2013 DOERL-2009-113 Rev ...

  18. Monthly Performance Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Oct-12 Nov-12 Dec-12 Jan-13 Feb-13 Mar-13 Apr-13 ... 4.01 3.89 4.02 4.12 4.22 4.27 4.36 First Aid Monthly First Aid 12-Month Average ... Report SEP 2013 DOERL-2009-113 Rev 48 ...

  19. Time and Attendance Reporting

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-10-22

    DOE O 535.1 establishes the Department's requirements and responsibilities governing time and attendance reporting. The purpose of this revision is to reflect the transition of payroll processing from the Capital Accounting Center to the Defense Finance and Accounting System. Cancels DOE O 3600.1B. Canceled by DOE O 322.1C.

  20. Final Technical Report

    SciTech Connect (OSTI)

    Gilbert, Chris

    2014-11-13

    The project, �Capital Investment to Fund Equipment Purchases and Facility Modifications to Create a Sustainable Future for EnergyXchange� served to replace landfill gas energy with alternative energy resources, primarily solar and wood waste. This is the final project closeout report.