National Library of Energy BETA

Sample records for rental agents landlords

  1. WPN 93-4: Landlord-Tenant Agreements

    Broader source: Energy.gov [DOE]

    To provide examples of landlord-tenant agreements currently in use which may assist states in developing rental procedures for their Program Year (PY) 1993 plans.

  2. Outreach to Multifamily Landlords and Tenants

    Broader source: Energy.gov [DOE]

    Better Buildings Residential Multifamily/Low-Income Peer Exchange Call Series: Outreach to Multifamily Landlords and Tenants, Call Slides and Discussion Summary, May 8, 2014.

  3. New Jersey Landlord, Tenants See Benefits of Retrofits | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Jersey Landlord, Tenants See Benefits of Retrofits New Jersey Landlord, Tenants See ... "Through their program, I was able to get new boilers installed, new windows and ...

  4. Implementation Model: Landlord-Owned Solar Helps

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Implementation Model: Landlord-Owned Solar Helps Retailer Offset More than 65% of Energy Use BARRIER Retailers in leased spaces are challenged to install on- site solar when it requires purchasing the system or relying on a third-party lease provider SOLUTION Work with the landlord who installs, owns, and maintains the solar array and sells power directly to the retailer at a fixed rate that is at or below electricity rates OUTCOME Retailer saves money and accesses clean power to meet 65% of

  5. Strategies to Overcome Split Incentive Tenant / Landlord Issues...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Strategies to Overcome Split Incentive Tenant Landlord Issues Better Buildings Residential Network Multifamily and Low-Income Peer Exchange Call: Strategies to Overcome Split ...

  6. Outreach to Multifamily Landlords and Tenants | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Trends in Multifamily Programs: What's Working and What's Challenging Strategies to Overcome Split Incentive Tenant Landlord Issues Coordinating Energy Efficiency With Water ...

  7. Strategies to Overcome Split Incentive Tenant / Landlord Issues

    Broader source: Energy.gov [DOE]

    Better Buildings Residential Network Multifamily and Low-Income Peer Exchange Call: Strategies to Overcome Split Incentive Tenant / Landlord Issues, call slides and discussion summary, September 25, 2014.

  8. EPA ENERGY STAR Webcast- Successes in Sustainability: Tenants and Landlords Team Up on Energy

    Broader source: Energy.gov [DOE]

    Achieving top-level performance in a multi-tenant office building has its challenges. Landlords must consider the many factors that contribute to a building’s energy efficiency, such as building...

  9. Landlord project multi-year program plan, fiscal year 1999, WBS 1.5

    SciTech Connect (OSTI)

    Dallas, M.D.

    1998-09-22

    The MYWP technical baseline describes the work to be accomplished by the Project and the technical standards which govern that work. The mission of Landlord Project is to provide more maintenance replacement of general infrastructure facilities and systems to facilitate the Hanford Site cleanup mission. Also, once an infrastructure facility or system is no longer needed the Landlord Project transitions the facility to final closure/removal through excess, salvage or demolition. Landlord Project activities will be performed in an environmentally sound, safe, economical, prudent, and reliable manner. The Landlord Project consists of the following facilities systems: steam, water, liquid sanitary waste, electrical distribution, telecommunication, sanitary landfill, emergency services, general purpose offices, general purpose shops, general purpose warehouses, environmental supports facilities, roads, railroad, and the site land. The objectives for general infrastructure support are reflected in two specific areas, (1) Core Infrastructure Maintenance, and (2) Infrastructure Risk Mitigation.

  10. Residential Rental Property Rebate Program

    Broader source: Energy.gov [DOE]

    Efficiency Vermont offers rebates for the installation of energy efficient equipment in existing multifamily buildings in Vermont for rental property owners. Managers of multifamily buildings may...

  11. Rental Vehicles | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rental Vehicles Enterprise Holdings Group was selected as the contracted rental car provider for The Ames Laboratory in Spring 2010. The contract was set up to minimize Ames Laboratory liability and to benefit The Ames Laboratory travelers. The contract includes a Liability policy and Collision Damage Waiver. See Enterprise Program Summary for details. Reservations may be made using the Ames Laboratory contracted travel agency, Travel and Transport (phone 515-292-8182) or by using the Enterprise

  12. Alternative Fuels Data Center: Rental Cars Go Electric in Florida

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Rental Cars Go Electric in Florida to someone by E-mail Share Alternative Fuels Data Center: Rental Cars Go Electric in Florida on Facebook Tweet about Alternative Fuels Data Center: Rental Cars Go Electric in Florida on Twitter Bookmark Alternative Fuels Data Center: Rental Cars Go Electric in Florida on Google Bookmark Alternative Fuels Data Center: Rental Cars Go Electric in Florida on Delicious Rank Alternative Fuels Data Center: Rental Cars Go Electric in Florida on Digg Find More places to

  13. WEATHERIZATION OF RENTAL UNITS FREQUENTLY ASKED QUESTIONS Administration

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    WEATHERIZATION OF RENTAL UNITS FREQUENTLY ASKED QUESTIONS Administration 1. What are the rental weatherization planning requirements for the Grantee? These requirements are detailed in the Annual Application Instructions, Section V, Master File, V.1.2. Approach to Determining Building Eligibility. Before weatherization of rental units, Grantees are required by DOE regulation (10 CFR 440.22(b)(3)) to establish, at a minimum, procedures for dwellings which consist of a rental unit or rental units,

  14. REAL ESTATE & EQUIPMENT LEASING / RENTAL CALIFORNIA LAWRENCE BERKELEY LAB

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    REAL ESTATE & EQUIPMENT LEASING / RENTAL CALIFORNIA LAWRENCE BERKELEY LAB POC David Chen Telephone (510) 486-4506 Email dtchen@lbl.gov Construction, Mining, and Forestry Machinery and Equipment Rental and Leasing 532412 Office Machinery and Equipment Rental and Leasing 532420 LAWRENCE LIVERMORE LAB POC Jill Swanson Telephone (925) 423-4535 Email swanson6@llnl.gov Construction, Mining, and Forestry Machinery and Equipment Rental and Leasing 532412 Office Machinery and Equipment Rental and

  15. WAP Memorandum 014: Feedback on Draft Multifamily and Rental WPNs |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy WAP Memorandum 014: Feedback on Draft Multifamily and Rental WPNs WAP Memorandum 014: Feedback on Draft Multifamily and Rental WPNs Effective: Nov. 23, 2015 This memo serves as an opportunity for WAP Grantees to review and provide comment on two draft Weatherization Program Notices (WPNs) developed by the U.S. Department of Energy (DOE). WAP Memorandum 014: Feedback on Draft Multifamily and Rental WPNs (140.6 KB) Draft Multifamily WPN (457.91 KB) Draft Rental Unit WPN

  16. How Do You Save Energy in Your Apartment or Rental?

    Broader source: Energy.gov [DOE]

    It's not always easy to find ways to save when you don't own your home, but there are simple things you can do to make your apartment or rental more comfortable and efficient.

  17. WPN 16-6: WEATHERIZATION OF RENTAL UNITS | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    6: WEATHERIZATION OF RENTAL UNITS WPN 16-6: WEATHERIZATION OF RENTAL UNITS Effective: May 5, 2016 To provide Grantees with updated guidance on weatherizing rental units in the Weatherization Assistance Program (WAP). The Department of Energy (DOE) has answered specific questions from Grantees related to the weatherization of rental units, whether single family building or multifamily dwellings, over a number of years. However, the responses to these questions have not been put forth in guidance.

  18. Burlington Electric Department- Multi-Family Rental Energy Efficiency Rebate Program

    Broader source: Energy.gov [DOE]

    Burlington Electric Department offers an innovative rebate program geared towards rental apartment owners. The program is designed to offer rebates on some of the most energy intensive household...

  19. I.C. 47-1605 - Geothermal Resources - Leases--Rental and Royalty...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: I.C. 47-1605 - Geothermal Resources - Leases--Rental and RoyaltyLegal Abstract This code...

  20. Phase I Water Rental Pilot Project : Snake River Resident Fish and Wildlife Resources and Management Recommendations.

    SciTech Connect (OSTI)

    Riggin, Stacey H.; Hansen, H. Jerome

    1992-10-01

    The Idaho Water Rental Pilot Project was implemented as a part of the Non-Treaty Storage Fish and Wildlife Agreement (NTSA) between Bonneville Power Administration and the Columbia Basin Fish and Wildlife Authority. The goal of the project is to improve juvenile and adult salmon and steelhead passage in the lower Snake River with the use of rented water for flow augmentation. The primary purpose of this project is to summarize existing resource information and provide recommendations to protect or enhance resident fish and wildlife resources in Idaho with actions achieving flow augmentation for anadromous fish. Potential impacts of an annual flow augmentation program on Idaho reservoirs and streams are modeled. Potential sources of water for flow augmentation and operational or institutional constraints to the use of that water are identified. This report does not advocate flow augmentation as the preferred long-term recovery action for salmon. The state of Idaho strongly believes that annual drawdown of the four lower Snake reservoirs is critical to the long-term enhancement and recovery of salmon (Andrus 1990). Existing water level management includes balancing the needs of hydropower production, irrigated agriculture, municipalities and industries with fish, wildlife and recreation. Reservoir minimum pool maintenance, water quality and instream flows are issues of public concern that will be directly affected by the timing and quantity of water rental releases for salmon flow augmentation, The potential of renting water from Idaho rental pools for salmon flow augmentation is complicated by institutional impediments, competition from other water users, and dry year shortages. Water rental will contribute to a reduction in carryover storage in a series of dry years when salmon flow augmentation is most critical. Such a reduction in carryover can have negative impacts on reservoir fisheries by eliminating shoreline spawning beds, reducing available fish habitat

  1. Energy Department Recognizes Landlords, Tenants Working Together...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Akridge Brandywine Realty Trust The Bullitt Foundation Empire State Realty Trust Jamestown, L.P. Kilroy Realty Corporation Kimco Realty Corporation Liberty Property Trust Oxford ...

  2. Hydroxypyridonate chelating agents

    DOE Patents [OSTI]

    Raymond, Kenneth N.; Scarrow, Robert C.; White, David L.

    1987-01-01

    Chelating agents having 1-hydroxy-2-pyridinone (HOPO) and related moieties incorporated within their structures, including polydentate HOPO-substituted polyamines such as spermidine and spermine, and HOPO-substituted desferrioxamine. The chelating agents are useful in selectively removing certain cations from solution, and are particularly useful as ferric ion and actinide chelators. Novel syntheses of the chelating agents are provided.

  3. Standard Agent Framework 1

    Energy Science and Technology Software Center (OSTI)

    1999-04-06

    The Standard Agent framework provides an extensible object-oriented development environment suitable for use in both research and applications projects. The SAF provides a means for constructing and customizing multi-agent systems through specialization of standard base classes (architecture-driven framework) and by composition of component classes (data driven framework). The standard agent system is implemented as an extensible object-centerd framework. Four concrete base classes are developed: (1) Standard Agency; (2) Standard Agent; (3) Human Factor, and (4)more » Resources. The object-centered framework developed and utilized provides the best comprimise between generality and flexibility available in agent development systems today.« less

  4. MpcAgent

    Energy Science and Technology Software Center (OSTI)

    2013-11-29

    MpcAgent software is a module for the VolltronLite platform from PNNL that regulates the operation of rooftop air conditioning units in small to medium commercial buildings for the purpose of reducing peak power consumption. The MpcAgent accomplishes this by restricting the number of units that may operate simultaneously and using a model predictive control strategy to select which units to operate in each control period. The outcome of this control is effective control of themore » building air temperature at the user specified set point while avoiding expensive peak demand charges that result from running all HVAC units simultaneously.« less

  5. Surface polymerization agents

    SciTech Connect (OSTI)

    Taylor, C.; Wilkerson, C.

    1996-12-01

    This is the final report of a 1-year, Laboratory-Directed R&D project at LANL. A joint technical demonstration was proposed between US Army Missile Command (Redstone Arsenal) and LANL. Objective was to demonstrate that an unmanned vehicle or missile could be used as a platform to deliver a surface polymerization agent in such a manner as to obstruct the filters of an air-breathing mechanism, resulting in operational failure.

  6. Rigid bifunctional chelating agents

    DOE Patents [OSTI]

    Sweet, Mark P. (Coram, NY); Mease, Ronnie C. (Fairfax, VA); Srivastava, Suresh C. (Setauket, NY)

    1998-07-21

    Bicyclo2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

  7. Rigid bifunctional chelating agents

    DOE Patents [OSTI]

    Sweet, M.P.; Mease, R.C.; Srivastava, S.C.

    1998-07-21

    Bicyclo[2.2.2] octane-2,3 diamine-N,N,N`,N`-tetraacetic acids (BODTA) and bicyclo[2.2.1] heptane-2,3 diamine-N,N,N`,N`-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

  8. Rigid bifunctional chelating agents

    DOE Patents [OSTI]

    Sweet, Mark P.; Mease, Ronnie C.; Srivastava, Suresh C.

    1998-07-21

    Bicyclo›2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo›2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

  9. Rigid bifunctional chelating agents

    DOE Patents [OSTI]

    Sweet, Mark P.; Mease, Ronnie C.; Srivastava, Suresh C.

    2000-02-08

    Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

  10. Liposome encapsulation of chelating agents

    DOE Patents [OSTI]

    Rahman, Yueh Erh

    1976-01-13

    A method for transferring a chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes and carrying the liposome-encapsulated chelating agent to the cellular membrane where the liposomes containing the chelating agent will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. A chelating agent can be introduced into the interior of a cell of a living organism wherein the liposomes will be decomposed, releasing the chelating agent to the interior of the cell. The released chelating agent will complex intracellularly deposited toxic heavy metals, permitting the more soluble metal complex to transfer across the cellular membrane from the cell and subsequently be removed from the living organism.

  11. Hydroxypyridonate and hydroxypyrimidinone chelating agents

    DOE Patents [OSTI]

    Raymond, Kenneth N.; Doble, Daniel M.; Sunderland, Christopher J.; Thompson, Marlon

    2005-01-25

    The present invention provides hydroxypyridinone and hydroxypyrimidone chelating agents. Also provides are Gd(III) complexes of these agents, which are useful as contrast enhancing agents for magnetic resonance imaging. The invention also provides methods of preparing the compounds of the invention, as well as methods of using the compounds in magnetic resonance imaging applications.

  12. Flexible, secure agent development framework

    DOE Patents [OSTI]

    Goldsmith; Steven Y.

    2009-04-07

    While an agent generator is generating an intelligent agent, it can also evaluate the data processing platform on which it is executing, in order to assess a risk factor associated with operation of the agent generator on the data processing platform. The agent generator can retrieve from a location external to the data processing platform an open site that is configurable by the user, and load the open site into an agent substrate, thereby creating a development agent with code development capabilities. While an intelligent agent is executing a functional program on a data processing platform, it can also evaluate the data processing platform to assess a risk factor associated with performing the data processing function on the data processing platform.

  13. Plasmids encoding therapeutic agents

    DOE Patents [OSTI]

    Keener, William K.

    2007-08-07

    Plasmids encoding anti-HIV and anti-anthrax therapeutic agents are disclosed. Plasmid pWKK-500 encodes a fusion protein containing DP178 as a targeting moiety, the ricin A chain, an HIV protease cleavable linker, and a truncated ricin B chain. N-terminal extensions of the fusion protein include the maltose binding protein and a Factor Xa protease site. C-terminal extensions include a hydrophobic linker, an L domain motif peptide, a KDEL ER retention signal, another Factor Xa protease site, an out-of-frame buforin II coding sequence, the lacZ.alpha. peptide, and a polyhistidine tag. More than twenty derivatives of plasmid pWKK-500 are described. Plasmids pWKK-700 and pWKK-800 are similar to pWKK-500 wherein the DP178-encoding sequence is substituted by RANTES- and SDF-1-encoding sequences, respectively. Plasmid pWKK-900 is similar to pWKK-500 wherein the HIV protease cleavable linker is substituted by a lethal factor (LF) peptide-cleavable linker.

  14. Agent Communications using Distributed Metaobjects

    SciTech Connect (OSTI)

    Goldsmith, Steven Y.; Spires, Shannon V.

    1999-06-10

    There are currently two proposed standards for agent communication languages, namely, KQML (Finin, Lobrou, and Mayfield 1994) and the FIPA ACL. Neither standard has yet achieved primacy, and neither has been evaluated extensively in an open environment such as the Internet. It seems prudent therefore to design a general-purpose agent communications facility for new agent architectures that is flexible yet provides an architecture that accepts many different specializations. In this paper we exhibit the salient features of an agent communications architecture based on distributed metaobjects. This architecture captures design commitments at a metaobject level, leaving the base-level design and implementation up to the agent developer. The scope of the metamodel is broad enough to accommodate many different communication protocols, interaction protocols, and knowledge sharing regimes through extensions to the metaobject framework. We conclude that with a powerful distributed object substrate that supports metaobject communications, a general framework can be developed that will effectively enable different approaches to agent communications in the same agent system. We have implemented a KQML-based communications protocol and have several special-purpose interaction protocols under development.

  15. Nuclear magnetic resonance contrast agents

    DOE Patents [OSTI]

    Smith, P.H.; Brainard, J.R.; Jarvinen, G.D.; Ryan, R.R.

    1997-12-30

    A family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this invention into the object prior to forming the images or during formation of the images. A contrast agent of this invention is a paramagnetic lanthanide hexaazamacrocyclic molecule, where a basic example has the formula LnC{sub 16}H{sub 14}N{sub 6}. Important applications of the invention are in medical diagnosis, treatment, and research, where images of portions of a human body are formed by means of magnetic resonance techniques. 10 figs.

  16. Nuclear magnetic resonance contrast agents

    DOE Patents [OSTI]

    Smith, Paul H.; Brainard, James R.; Jarvinen, Gordon D.; Ryan, Robert R.

    1997-01-01

    A family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this invention into the object prior to forming the images or during formation of the images. A contrast agent of this invention is a paramagnetic lanthanide hexaazamacrocyclic molecule, where a basic example has the formula LnC.sub.16 H.sub.14 N.sub.6. Important applications of the invention are in medical diagnosis, treatment, and research, where images of portions of a human body are formed by means of magnetic resonance techniques.

  17. Triggered pore-forming agents

    DOE Patents [OSTI]

    Bayley, Hagan; Walker, Barbara J.; Chang, Chung-yu; Niblack, Brett; Panchal, Rekha

    1998-01-01

    An inactive pore-forming agent which is activated to lytic function by a condition such as pH, light, heat, reducing potential, or metal ion concentration, or substance such as a protease, at the surface of a cell.

  18. Business Models Guide: Real Estate Agent

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    BUSINESS MODELS GUIDE - Real Estate Agent REAL ESTATE AGENT A real estate agent acts as an intermediary for the sale and purchase of buildings and land. "Realtor ® " is a trademarked term for real estate agents affiliated with the National Association of Realtors (NAR). Most agents and brokers are active in the residential market, but some specialize in commercial or agricultural properties. Only licensed brokers are allowed to sell properties, so they often sponsor real estate agents

  19. Agent review phase one report.

    SciTech Connect (OSTI)

    Zubelewicz, Alex Tadeusz; Davis, Christopher Edward; Bauer, Travis LaDell

    2009-12-01

    This report summarizes the findings for phase one of the agent review and discusses the review methods and results. The phase one review identified a short list of agent systems that would prove most useful in the service architecture of an information management, analysis, and retrieval system. Reviewers evaluated open-source and commercial multi-agent systems and scored them based upon viability, uniqueness, ease of development, ease of deployment, and ease of integration with other products. Based on these criteria, reviewers identified the ten most appropriate systems. The report also mentions several systems that reviewers deemed noteworthy for the ideas they implement, even if those systems are not the best choices for information management purposes.

  20. Nucleotide cleaving agents and method

    DOE Patents [OSTI]

    Que, Jr., Lawrence; Hanson, Richard S.; Schnaith, Leah M. T.

    2000-01-01

    The present invention provides a unique series of nucleotide cleaving agents and a method for cleaving a nucleotide sequence, whether single-stranded or double-stranded DNA or RNA, using and a cationic metal complex having at least one polydentate ligand to cleave the nucleotide sequence phosphate backbone to yield a hydroxyl end and a phosphate end.

  1. Triggered pore-forming agents

    DOE Patents [OSTI]

    Bayley, H.; Walker, B.J.; Chang, C.Y.; Niblack, B.; Panchal, R.

    1998-07-07

    An inactive pore-forming agent is revealed which is activated to lytic function by a condition such as pH, light, heat, reducing potential, or metal ion concentration, or substance such as a protease, at the surface of a cell. 30 figs.

  2. Limonene and tetrahydrofurfuryl alcohol cleaning agent

    DOE Patents [OSTI]

    Bohnert, George W.; Carter, Richard D.; Hand, Thomas E.; Powers, Michael T.

    1996-05-07

    The present invention is a tetrahydrofurfuryl alcohol and limonene or terpineol cleaning agent and method for formulating and/or using the cleaning agent. This cleaning agent effectively removes both polar and nonpolar contaminants from various electrical and mechanical parts and is readily used without surfactants, thereby reducing the need for additional cleaning operations. The cleaning agent is warm water rinsable without the use of surfactants. The cleaning agent can be azeotropic, enhancing ease of use in cleaning operations and ease of recycling.

  3. Limonene and tetrahydrofurfurly alcohol cleaning agent

    DOE Patents [OSTI]

    Bohnert, George W.; Carter, Richard D.; Hand, Thomas E.; Powers, Michael T.

    1997-10-21

    The present invention is a tetrahydrofurfuryl alcohol and limonene cleaning agent and method for formulating and/or using the cleaning agent. This cleaning agent effectively removes both polar and nonpolar contaminants from various electrical and mechanical parts and is readily used without surfactants, thereby reducing the need for additional cleaning operations. The cleaning agent is warm water rinsable without the use of surfactants. The cleaning agent can be azeotropic, enhancing ease of use in cleaning operations and ease of recycling.

  4. Limonene and tetrahydrofurfuryl alcohol cleaning agent

    DOE Patents [OSTI]

    Bohnert, G.W.; Carter, R.D.; Hand, T.E.; Powers, M.T.

    1997-10-21

    The present invention is a tetrahydrofurfuryl alcohol and limonene cleaning agent and method for formulating and/or using the cleaning agent. This cleaning agent effectively removes both polar and nonpolar contaminants from various electrical and mechanical parts and is readily used without surfactants, thereby reducing the need for additional cleaning operations. The cleaning agent is warm water rinsable without the use of surfactants. The cleaning agent can be azeotropic, enhancing ease of use in cleaning operations and ease of recycling.

  5. HUD's Rental Assistance Demonstration Program

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Staying Warm & Saving Energy this Winter Webinar Series sponsored by Housing and Urban Development, Department of Energy and Department of Education December 17, 2015  Welcome and intro to webinar series  Introduction of presenter, Madeline Salzman  Resident Engagement Toolkit overview  Building knowledge  Changing behavior  Inspiring social change  Q & A You are on mute! Use your webinar bar to fill out poll or chat to send in a question. Email

  6. HUD's Rental Assistance Demonstration Program

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Digitally Engaged Communities: Helping Residents Get Online and Thrive Online Webinar Series sponsored by Housing and Urban Development, Department of Energy and Department of Education April 21, 2016 DIGITALLY ENGAGED COMMUNITIES: HELPING RESIDENTS GET ONLINE AND THRIVE ONLINE Amber Petty Ron Clewer Jada Johnson National Program Coordinator CEO Admin Services Assistant EveryoneOn Rockford Housing Little Rock Metro Housing amber@everyoneon.org rclewer@rockfordha.org jjohnson@mhapha.org * Welcome

  7. HUD's Rental Assistance Demonstration Program

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Webinar Series sponsored by Housing and Urban Development, ... SEED: Coalitions for Community Growth Madeline Salzman SEED ... 4-25: Coloring Sheets for Children - Lighting Exhibit ...

  8. HUD's Rental Assistance Demonstration Program

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Questionnaire Staff Commitment and Resident Awareness ... Bill How Much Electricity do I Use? "Switch-a-bulb" during annual unit inspections Point-of-use ...

  9. Learning other agents` preferences in multiagent negotiation

    SciTech Connect (OSTI)

    Bui, H.H.; Kieronska, D.; Venkatesh, S.

    1996-12-31

    In multiagent systems, an agent does not usually have complete information about the preferences and decision making processes of other agents. This might prevent the agents from making coordinated choices, purely due to their ignorance of what others want. This paper describes the integration of a learning module into a communication-intensive negotiating agent architecture. The learning module gives the agents the ability to learn about other agents` preferences via past interactions. Over time, the agents can incrementally update their models of other agents` preferences and use them to make better coordinated decisions. Combining both communication and learning, as two complement knowledge acquisition methods, helps to reduce the amount of communication needed on average, and is justified in situations where communication is computationally costly or simply not desirable (e.g. to preserve the individual privacy).

  10. Chelating agents for technetium-99M

    DOE Patents [OSTI]

    Fritzberg, A.R.; Kasina, S.

    1987-06-02

    The present invention relates to a novel family of Technetium chelating agents (ligands) based upon amide and mercaptide donor groups.

  11. Chelating agents for technetium-99M

    DOE Patents [OSTI]

    Fritzberg, Alan R.; Kasina, Sudhakar

    1987-01-01

    The present invention relates to a novel family of Technetium chelating agents (ligands) based upon amide and mercaptide donor groups.

  12. Extinguishing agent for combustible metal fires

    DOE Patents [OSTI]

    Riley, John F.; Stauffer, Edgar Eugene

    1976-10-12

    A low chloride extinguishing agent for combustible metal fires comprising from substantially 75 to substantially 94 weight percent of sodium carbonate as the basic fire extinguishing material, from substantially 1 to substantially 5 weight percent of a water-repellent agent such as a metal stearate, from substantially 2 to substantially 10 weight percent of a flow promoting agent such as attapulgus clay, and from substantially 3 to substantially 15 weight percent of a polyamide resin as a crusting agent.

  13. Agent-based Infrastructure Interdependency Model

    Energy Science and Technology Software Center (OSTI)

    2003-10-01

    The software is used to analyze infrastructure interdependencies. Agent-based modeling is used for the analysis.

  14. Agent-based modeling of complex infrastructures

    SciTech Connect (OSTI)

    North, M. J.

    2001-06-01

    Complex Adaptive Systems (CAS) can be applied to investigate complex infrastructures and infrastructure interdependencies. The CAS model agents within the Spot Market Agent Research Tool (SMART) and Flexible Agent Simulation Toolkit (FAST) allow investigation of the electric power infrastructure, the natural gas infrastructure and their interdependencies.

  15. Radioactive scanning agents with hydroquinone stabilizer

    SciTech Connect (OSTI)

    Whitehouse, H.S.

    1980-10-21

    Stable compositions, useful as technetium-99m-based scintigraphic agents, comprise hydroquinone in combination with a pertechnetate reducing agent or dissolved in pertechnetate-99m (99mtco4-) solution. The compositions are especially useful in combination with a phosphate or phosphonate material which carries the radionuclide to bone, thus providing a skeletal imaging agent.

  16. Hydroxypyridonate chelating agents and synthesis thereof

    DOE Patents [OSTI]

    Raymond, K.N.; Scarrow, R.C.; White, D.L.

    1985-11-12

    Chelating agents having 1-hydroxy-2-pyridinone (HOPO) and related moieties incorporated within their structures, including polydentate HOPO-substituted polyamines such as spermidine and spermine, and HOPO-substituted desferrioxamine. The chelating agents are useful in selectively removing certain cations from solution, and are particularly useful as ferric ion and actinide chelators. Novel syntheses of the chelating agents are provided. 4 tabs.

  17. Method For Detecting Biological Agents

    DOE Patents [OSTI]

    Chen, Liaohai; McBranch, Duncan W.; Wang, Hsing-Lin; Whitten, David G.

    2005-12-27

    A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-altering element bound thereto and capable of altering the measurable property, the intermediate combination adapted for subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the intermediate combination from the polymer results in a detectable change in the alterable measurable property, and, detecting said detectable change in the alterable measurable property.

  18. A New Understanding of Chemical Agent Release

    SciTech Connect (OSTI)

    Nakafuji, G; Greenman, R; Theofanous, T

    2002-07-24

    The evolution of thickened chemical agent released at supersonic velocities, due to a missile defense intercept or a properly functioning warhead, has been misunderstood. Current and historical experimental and modeling efforts have attributed agent breakup to a variety of droplet breakup mechanisms. According to this model, drops of agent fragment into subsequent generations of smaller drops until a stable drop size is reached. Recent experimental data conducted in a supersonic wind tunnel show that agent breakup is not driven by any droplet breakup mechanism. The breakup of agent is instead governed by viscoelastic behavior and aerodynamic history effects. This viscoelastic breakup mechanism results in the formation of threads and sheets of liquid, instead of drops. The evolution and final state of agent released has broad implications not only for aerobreakup models, but also for all atmospheric dispersion models.

  19. Building Agent Software - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Analysis Energy Analysis Find More Like This Return to Search Building Agent Software Occupancy Feedback for Building Controls National Renewable Energy Laboratory Contact NREL About This Technology Publications: PDF Document Publication Progress on Enabling an Interactive Conversation Between Commercial Building Occupants and Their Building To Improve Comfort and Energy Efficiency (948 KB) <p> Building Agent System Architecture</p> Building Agent System Architecture <p>

  20. MRI contrast agents and high-throughput screening by MRI

    DOE Patents [OSTI]

    Lu, Yi; Yigit, Mehmet Veysel; Mazumdar, Debapriya

    2013-10-29

    The present invention provides an MRI contrast agent, comprising: MRI contrast agent particles, and oligonucleotides, attached to the particles.

  1. Oak Ridge Mobile Agent Community (ORMAC)

    Energy Science and Technology Software Center (OSTI)

    2003-06-30

    The Oak Ridge Mobile Agent Community (ORMAC) framework software facilitates the execution of a collection of mobile software agents across a heterogeneous collection of computer systems. ORMAC provides the software agents with the ability to communicate with each other in a synchronous and asynchronous manner. Also, ORMAC allows the software agents to move to any computer system in the community and continue execution there. ORMAC is intended to aid programmers in solving a very generalmore » set of distributed software problems.« less

  2. Assurance in Agent-Based Systems

    SciTech Connect (OSTI)

    Gilliom, Laura R.; Goldsmith, Steven Y.

    1999-05-10

    Our vision of the future of information systems is one that includes engineered collectives of software agents which are situated in an environment over years and which increasingly improve the performance of the overall system of which they are a part. At a minimum, the movement of agent and multi-agent technology into National Security applications, including their use in information assurance, is apparent today. The use of deliberative, autonomous agents in high-consequence/high-security applications will require a commensurate level of protection and confidence in the predictability of system-level behavior. At Sandia National Laboratories, we have defined and are addressing a research agenda that integrates the surety (safety, security, and reliability) into agent-based systems at a deep level. Surety is addressed at multiple levels: The integrity of individual agents must be protected by addressing potential failure modes and vulnerabilities to malevolent threats. Providing for the surety of the collective requires attention to communications surety issues and mechanisms for identifying and working with trusted collaborators. At the highest level, using agent-based collectives within a large-scale distributed system requires the development of principled design methods to deliver the desired emergent performance or surety characteristics. This position paper will outline the research directions underway at Sandia, will discuss relevant work being performed elsewhere, and will report progress to date toward assurance in agent-based systems.

  3. Natural chelating agents for radionuclide decorporation

    DOE Patents [OSTI]

    Premuzic, E.T.

    1985-06-11

    This invention relates to the production of metal-binding compounds useful for the therapy of heavy metal poisoning, for biological mining and for decorporation of radionuclides. The present invention deals with an orderly and effective method of producing new therapeutically effective chelating agents. This method uses challenge biosynthesis for the production of chelating agents that are specific for a particular metal. In this approach, the desired chelating agents are prepared from microorganisms challenged by the metal that the chelating agent is designed to detoxify. This challenge induces the formation of specific or highly selective chelating agents. The present invention involves the use of the challenge biosynthetic method to produce new complexing/chelating agents that are therapeutically useful to detoxify uranium, plutonium, thorium and other toxic metals. The Pseudomonas aeruginosa family of organisms is the referred family of microorganisms to be used in the present invention to produce the new chelating agent because this family is known to elaborate strains resistant to toxic metals.

  4. Energy Department Recognizes Landlords, Tenants Working Together to Save Energy in Commercial Buildings

    Broader source: Energy.gov [DOE]

    The Energy Department today honored 14 organizations, naming them as 2014 Green Lease Leaders for their commitment to reducing energy waste and increasing efficiency in commercial buildings.

  5. An evaluation of the effectiveness of lead paint hazard reduction when conducted by homeowners and landlords

    SciTech Connect (OSTI)

    Etre, L.A.; Reynolds, S.J.; Burmeister, L.F.; Whitten, P.S.; Gergely, R.

    1999-08-01

    This research project was conducted in collaboration with the Iowa Department of Public Health to evaluate whether property owners who follow recommended procedures for lead-based paint removal/repair can do the work safely and effectively. This study included 29 homes where a lead-based paint hazard had been identified and lead-based paint was removed or repaired (hazard reduction). Exposure evaluation included pre-project surface dust wipe sampling, air monitoring during lead-based paint removal, post-project surface dust wipe sampling, and pre- and post-project blood samples from adult study participants. The comparison of surface dust wipe samples taken before and after lead paint hazard reduction was used to evaluate the effectiveness of lead paint hazard reduction. The lead loadings on window sill surfaces in the work area were significantly lower after completion of the project, and the lead-based paint removal did not contaminate the adjoining living area. The proportion of homes with surface dust lead loading exceeding Department of Housing and Urban Development (HUD) clearance standard was 73% pre-project and 38% post-project. Personal airborne exposures during lead removal activities reinforce the need to respiratory protection and good hygiene. There was no difference in adult pre-/post-blood levels, indicating that participants die remove lead in a safe manner with respect to their own exposures. The results indicate that hazard reduction can be done effectively when recommended procedures for the removal of lead-based paint are followed.

  6. Knowledge Acquisition Ubiquitous Agent Infrastructure (KAUAI)

    Energy Science and Technology Software Center (OSTI)

    2009-09-15

    Mobile agents are autonomous software programs that can move from one host to another during the course of execution. The KAUAI computer code is a middleware that supports the rapid development and deployment of mobile agent based applications. It is built on the J2ME (CLDC) technology. KAUAI handles the instantiation, execution, transportation, and disposal of mobile agents. KAUAI masks the underlying hardware and communication details from application developers and provides flexible functionality for distributed computing.more » KAUAI supports software development in systems that involve a large number of heterogeneous computing platforms ranging from workstations to handheld devices.« less

  7. Precursors to radiopharmaceutical agents for tissue imaging

    DOE Patents [OSTI]

    Srivastava, Prem C.; Knapp, Jr., Furn F.

    1988-01-01

    A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.

  8. Business Models Guide: Real Estate Agent | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Models Guide: Real Estate Agent Business Models Guide: Real Estate Agent With excellent marketing skills, a keen understanding of financing options, and a broad knowledge of the ...

  9. Temporary Bridging Agents for Use in Drilling and Completions...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Temporary Bridging Agents for Use in Drilling and Completions of EGS Temporary Bridging Agents for Use in Drilling and Completions of EGS DOE Geothermal Peer Review 2010 - ...

  10. FIPA agent based network distributed control system

    SciTech Connect (OSTI)

    D. Abbott; V. Gyurjyan; G. Heyes; E. Jastrzembski; C. Timmer; E. Wolin

    2003-03-01

    A control system with the capabilities to combine heterogeneous control systems or processes into a uniform homogeneous environment is discussed. This dynamically extensible system is an example of the software system at the agent level of abstraction. This level of abstraction considers agents as atomic entities that communicate to implement the functionality of the control system. Agents' engineering aspects are addressed by adopting the domain independent software standard, formulated by FIPA. Jade core Java classes are used as a FIPA specification implementation. A special, lightweight, XML RDFS based, control oriented, ontology markup language is developed to standardize the description of the arbitrary control system data processor. Control processes, described in this language, are integrated into the global system at runtime, without actual programming. Fault tolerance and recovery issues are also addressed.

  11. NISAC Agent Based Laboratory for Economics

    Energy Science and Technology Software Center (OSTI)

    2006-10-11

    The software provides large-scale microeconomic simulation of complex economic and social systems (such as supply chain and market dynamics of businesses in the US economy) and their dependence on physical infrastructure systems. The system is based on Agent simulation, where each entity of inteest in the system to be modeled (for example, a Bank, individual firms, Consumer households, etc.) is specified in a data-driven sense to be individually repreented by an Agent. The Agents interactmore » using rules of interaction appropriate to their roles, and through those interactions complex economic and social dynamics emerge. The software is implemented in three tiers, a Java-based visualization client, a C++ control mid-tier, and a C++ computational tier.« less

  12. NISAC Agent Based Laboratory for Economics

    SciTech Connect (OSTI)

    2006-10-11

    The software provides large-scale microeconomic simulation of complex economic and social systems (such as supply chain and market dynamics of businesses in the US economy) and their dependence on physical infrastructure systems. The system is based on Agent simulation, where each entity of inteest in the system to be modeled (for example, a Bank, individual firms, Consumer households, etc.) is specified in a data-driven sense to be individually repreented by an Agent. The Agents interact using rules of interaction appropriate to their roles, and through those interactions complex economic and social dynamics emerge. The software is implemented in three tiers, a Java-based visualization client, a C++ control mid-tier, and a C++ computational tier.

  13. Detection of electrophilic and nucleophilic chemical agents

    DOE Patents [OSTI]

    McElhanon, James R.; Shepodd, Timothy J.

    2014-08-12

    A "real time" method for detecting chemical agents generally and particularly electrophilic and nucleophilic species by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species. By bonding or otherwise attaching these precursor molecules to a surface or substrate they can be used in numerous applications.

  14. Intelligent Software Agents: Sensor Integration and Response

    SciTech Connect (OSTI)

    Kulesz, James J; Lee, Ronald W

    2013-01-01

    Abstract In a post Macondo world the buzzwords are Integrity Management and Incident Response Management. The twin processes are not new but the opportunity to link the two is novel. Intelligent software agents can be used with sensor networks in distributed and centralized computing systems to enhance real-time monitoring of system integrity as well as manage the follow-on incident response to changing, and potentially hazardous, environmental conditions. The software components are embedded at the sensor network nodes in surveillance systems used for monitoring unusual events. When an event occurs, the software agents establish a new concept of operation at the sensing node, post the event status to a blackboard for software agents at other nodes to see , and then react quickly and efficiently to monitor the scale of the event. The technology addresses a current challenge in sensor networks that prevents a rapid and efficient response when a sensor measurement indicates that an event has occurred. By using intelligent software agents - which can be stationary or mobile, interact socially, and adapt to changing situations - the technology offers features that are particularly important when systems need to adapt to active circumstances. For example, when a release is detected, the local software agent collaborates with other agents at the node to exercise the appropriate operation, such as: targeted detection, increased detection frequency, decreased detection frequency for other non-alarming sensors, and determination of environmental conditions so that adjacent nodes can be informed that an event is occurring and when it will arrive. The software agents at the nodes can also post the data in a targeted manner, so that agents at other nodes and the command center can exercise appropriate operations to recalibrate the overall sensor network and associated intelligence systems. The paper describes the concepts and provides examples of real-world implementations

  15. Imaging agent and method of use

    DOE Patents [OSTI]

    Wieland, Donald M.; Brown, Lawrence E.; Beierwaltes, William H.; Wu, Jiann-long

    1986-04-22

    A new radiopharmaceutical composition for use in nuclear medicine comprises a radioiodinated meta-iodobenzylguanidine. The composition is used as an imaging agent for the heart, adrenal medulla, and tumors of the adrenal medulla and can be used for treatment of tumors of the adrenal medulla.

  16. Imaging agent and method of use

    DOE Patents [OSTI]

    Wieland, D.M.; Brown, L.E.; Beierwaltes, W.H.; Wu, J.L.

    1986-04-22

    A new radiopharmaceutical composition for use in nuclear medicine comprises a radioiodinated meta-iodobenzylguanidine. The composition is used as an imaging agent for the heart, adrenal medulla, and tumors of the adrenal medulla and can be used for treatment of tumors of the adrenal medulla. No Drawings

  17. Detection of Electrophilic and Nucleophilic Chemical Agents

    DOE Patents [OSTI]

    McElhanon, James R.; Shepodd, Timothy J.

    2008-11-11

    A "real time" method for detecting electrophilic and nucleophilic species generally by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species.

  18. Natural chelating agents for radionuclide decorporation

    DOE Patents [OSTI]

    Premuzic, Eugene T.

    1988-01-01

    This invention relates to the preparation of new, naturally produced chelating agents as well as to the method and resulting chelates of desorbing cultures in a bioavailable form involving Pseudomonas species or other microorganisms. A preferred microorganism is Pseudomonas aeruginosa which forms multiple chelates with thorium in the range of molecular weight 100-1,000 and also forms chelates with uranium of molecular weight in the area of 100-1,000 and 1,000-2,000.

  19. Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes

    DOE Patents [OSTI]

    Rahman, Yueh Erh

    1977-11-10

    A method is provided for transferring a polyaminopolycarboxylic acid chelating agent across a cellular membrane by encapsulating the charged chelating agent within liposomes, which liposomes will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. The chelating agent is encapsulated within liposomes by drying a lipid mixture to form a thin film and wetting the lipid film with a solution containing the chelating agent. Mixing then results in the formation of a suspension of liposomes encapsulating the chelating agent, which liposomes can then be separated.

  20. Commercial Buildings Sector Agent-Based Model | Open Energy Informatio...

    Open Energy Info (EERE)

    OpenEI Keyword(s): EERE tool, Commercial Buildings Sector Agent-Based Model Language: English References: Building Efficiency: Development of an Agent-based Model of the US...

  1. Lithium based electrochemical cell systems having a degassing agent

    DOE Patents [OSTI]

    Hyung, Yoo-Eup; Vissers, Donald R.; Amine, Khalil

    2012-05-01

    A lithium based electrochemical cell system includes a positive electrode; a negative electrode; an electrolyte; and a degassing agent.

  2. Agent-Based Mediation and Cooperative Information Systems

    SciTech Connect (OSTI)

    PHILLIPS, LAURENCE R.; LINK, HAMILTON E.; GOLDSMITH, STEVEN Y.

    2002-06-02

    This report describes the results of research and development in the area of communication among disparate species of software agents. The two primary elements of the work are the formation of ontologies for use by software agents and the means by which software agents are instructed to carry out complex tasks that require interaction with other agents. This work was grounded in the areas of commercial transport and cybersecurity.

  3. Business Models Guide: Real Estate Agent | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Business Models Guide: Real Estate Agent Business Models Guide: Real Estate Agent With excellent marketing skills, a keen understanding of financing options, and a broad knowledge of the industry, real estate agents are natural advocates for smart energy efficiency upgrades. Business Models Guide: Real Estate Agent (50.43 KB) More Documents & Publications Working with the Real Estate Sector Business Models and Case Examples for Working with the Real Estate Sector Trends in Real Estate and

  4. Modular strategies for PET imaging agents

    SciTech Connect (OSTI)

    Hooker, , J.M.

    2010-03-01

    In recent years, modular and simplified chemical and biological strategies have been developed for the synthesis and implementation of positron emission tomography (PET) radiotracers. New developments in bioconjugation and synthetic methodologies, in combination with advances in macromolecular delivery systems and gene-expression imaging, reflect a need to reduce radiosynthesis burden in order to accelerate imaging agent development. These new approaches, which are often mindful of existing infrastructure and available resources, are anticipated to provide a more approachable entry point for researchers interested in using PET to translate in vitro research to in vivo imaging.

  5. Designed TPR Modules as Novel Anticancer Agents

    SciTech Connect (OSTI)

    Cortajarena,A.; Yi, F.; Regan, L.

    2008-01-01

    Molecules specifically designed to modulate protein-protein interactions have tremendous potential as novel therapeutic agents. One important anticancer target is the chaperone Hsp90, whose activity is essential for the folding of many oncogenic proteins, including HER2, IGFIR, AKT, RAF-1, and FLT-3. Here we report the design and characterization of new tetratricopeptide repeat modules, which bind to the C-terminus of Hsp90 with higher affinity and with greater specificity than natural Hsp90-binding co-chaperones. Thus, when these modules are introduced into the cell, they out-compete endogenous co-chaperones for binding, thereby inhibiting Hsp90 function. The effect of Hsp90 inhibition in this fashion is dramatic; HER2 levels are substantially decreased and BT474 HER2 positive breast cancer cells are killed. Our designs thus provide new tools with which to dissect the mechanism of Hsp90-mediated protein folding and also open the door to the development of an entirely new class of anticancer agents.

  6. Epoxy foams using multiple resins and curing agents

    DOE Patents [OSTI]

    Russick, Edward M.; Rand, Peter B.

    2000-01-01

    An epoxy foam comprising a plurality of resins, a plurality of curing agents, at least one blowing agent, at least one surfactant and optionally at least one filler and the process for making. Preferred is an epoxy foam comprising two resins of different reactivities, two curing agents, a blowing agent, a surfactant, and a filler. According to the present invention, an epoxy foam is prepared with tailorable reactivity, exotherm, and pore size by a process of admixing a plurality of resins with a plurality of curing agents, a surfactant and blowing agent, whereby a foamable mixture is formed and heating said foamable mixture at a temperature greater than the boiling temperature of the blowing agent whereby said mixture is foamed and cured.

  7. Fluid extraction using carbon dioxide and organophosphorus chelating agents

    DOE Patents [OSTI]

    Smart, N.G.; Wai, C.M.; Lin, Y.; Kwang, Y.H.

    1998-11-24

    Methods for extracting metalloid and metal species from a solid or liquid material by exposing the material to a fluid solvent, particularly supercritical CO{sub 2}, and a chelating agent are described. The chelating agent forms a chelate with the species, the chelate being soluble in the fluid to allow removal of the species from the material. In preferred embodiments the extraction solvent is supercritical CO{sub 2} and the chelating agent comprises an organophosphorous chelating agent, particularly sulfur-containing organophosphorous chelating agents, including mixtures of chelating agents. Examples of chelating agents include monothiophosphinic acid, di-thiophosphinic acid, phosphine sulfite, phosphorothioic acid, and mixtures thereof. The method provides an environmentally benign process for removing metal and metalloids from industrial waste solutions, particularly acidic solutions. Both the chelate and the supercritical fluid can be regenerated and the contaminant species recovered to provide an economic, efficient process. 1 fig.

  8. Fluid extraction using carbon dioxide and organophosphorus chelating agents

    DOE Patents [OSTI]

    Smart, Neil G.; Wai, Chien M.; Lin, Yuehe; Kwang, Yak Hwa

    1998-01-01

    Methods for extracting metalloid and metal species from a solid or liquid material by exposing the material to a fluid solvent, particularly supercritical CO.sub.2, and a chelating agent are described. The chelating agent forms a chelate with the species, the chelate being soluble in the fluid to allow removal of the species from the material. In preferred embodiments the extraction solvent is supercritical CO.sub.2 and the chelating agent comprises an organophosphorous chelating agent, particularly sulfur-containing organophosphorous chelating agents, including mixtures of chelating agents. Examples of chelating agents include monothiophosphinic acid, di-thiophosphinic acid, phosphine sulfite, phosphorothioic acid, and mixtures thereof. The method provides an environmentally benign process for removing metal and metalloids from industrial waste solutions, particularly acidic solutions. Both the chelate and the supercritical fluid can be regenerated and the contaminant species recovered to provide an economic, efficient process.

  9. Agent-Based Software for Gathering and Summarizing Textual and...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Find More Like This Return to Search Agent-Based Software for Gathering and Summarizing ... This requires software that can quickly filter, relate, and show documents and ...

  10. A mobile-agent based wireless sensing network for structural...

    Office of Scientific and Technical Information (OSTI)

    Furthermore, the mobile agent provides computational power to make near real-time assessments on the structural conditions. This paper will discuss such prototype systems, which ...

  11. A mobile-agent based wireless sensing network for structural...

    Office of Scientific and Technical Information (OSTI)

    Title: A mobile-agent based wireless sensing network for structural health monitoring ... Office of Scientific and Technical Information (OSTI) and is provided as a public service. ...

  12. Operating Experience Level 3, NRC Notice: Antifreeze Agents in...

    Broader source: Energy.gov (indexed) [DOE]

    October 2015 OE-3 2015-04: NRC Notice: Antifreeze Agents in Fire Water Sprinkler Systems This Operating Experience Level 3 (OE-3) document provides information about safety...

  13. A mobile-agent based wireless sensing network for structural...

    Office of Scientific and Technical Information (OSTI)

    for structural health monitoring applications Citation Details In-Document Search Title: A mobile-agent based wireless sensing network for structural health monitoring ...

  14. ORISE: Agents of Opportunity for Terrorism Continuing Medical...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Agents of Opportunity for Terrorism On-line CME Course on Toxic Radiological Materials, Toxic Industrial Chemicals, and Toxic Industrial Materials Dates Scheduled Available 247...

  15. Agent-based method for distributed clustering of textual information

    DOE Patents [OSTI]

    Potok, Thomas E [Oak Ridge, TN; Reed, Joel W [Knoxville, TN; Elmore, Mark T [Oak Ridge, TN; Treadwell, Jim N [Louisville, TN

    2010-09-28

    A computer method and system for storing, retrieving and displaying information has a multiplexing agent (20) that calculates a new document vector (25) for a new document (21) to be added to the system and transmits the new document vector (25) to master cluster agents (22) and cluster agents (23) for evaluation. These agents (22, 23) perform the evaluation and return values upstream to the multiplexing agent (20) based on the similarity of the document to documents stored under their control. The multiplexing agent (20) then sends the document (21) and the document vector (25) to the master cluster agent (22), which then forwards it to a cluster agent (23) or creates a new cluster agent (23) to manage the document (21). The system also searches for stored documents according to a search query having at least one term and identifying the documents found in the search, and displays the documents in a clustering display (80) of similarity so as to indicate similarity of the documents to each other.

  16. Cell-targeted lytic pore-forming agents

    DOE Patents [OSTI]

    Bayley, Hagen; Walker, Barbara J.

    1998-01-01

    A chimeric compound that contains a cell-specific ligand linked to a pore-forming agent capable of lysing a cell.

  17. Cell-targeted lytic pore-forming agents

    DOE Patents [OSTI]

    Bayley, H.; Walker, B.J.

    1998-10-06

    A chimeric compound that contains a cell-specific ligand linked to a pore-forming agent capable of lysing a cell. 21 figs.

  18. Cell-targeted lytic pore-forming agents

    DOE Patents [OSTI]

    Bayley, H.; Walker, B.J.

    1998-10-20

    A chimeric compound that contains a cell-specific ligand linked to a pore-forming agent capable of lysing a cell. 18 figs.

  19. Surface Modification Agents Increase Safety, Security of Lithium...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Surface Modification Agents Increase Safety, Security of Lithium-Ion Batteries New Process to Modify the Surface of the Active Material Used in Lithium-Ion Batteries Argonne ...

  20. Surface Modification Agents for Lithium-Ion Batteries | Argonne...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Surface Modification Agents for Lithium-Ion Batteries Technology available for licensing: ... and security of batteries Substantially reduces power fade and potential for explosions. ...

  1. A multi-agent system for coordinating international shipping

    SciTech Connect (OSTI)

    Goldsmith, S.Y.; Phillips, L.R.; Spires, S.V.

    1998-05-01

    Moving commercial cargo across the US-Mexico border is currently a complex, paper-based, error-prone process that incurs expensive inspections and delays at several ports of entry in the Southwestern US. Improved information handling will dramatically reduce border dwell time, variation in delivery time, and inventories, and will give better control of the shipment process. The Border Trade Facilitation System (BTFS) is an agent-based collaborative work environment that assists geographically distributed commercial and government users with transshipment of goods across the US-Mexico border. Software agents mediate the creation, validation and secure sharing of shipment information and regulatory documentation over the Internet, using the World Wide Web to interface with human actors. Agents are organized into Agencies. Each agency represents a commercial or government agency. Agents perform four specific functions on behalf of their user organizations: (1) agents with domain knowledge elicit commercial and regulatory information from human specialists through forms presented via web browsers; (2) agents mediate information from forms with diverse otologies, copying invariant data from one form to another thereby eliminating the need for duplicate data entry; (3) cohorts of distributed agents coordinate the work flow among the various information providers and they monitor overall progress of the documentation and the location of the shipment to ensure that all regulatory requirements are met prior to arrival at the border; (4) agents provide status information to human actors and attempt to influence them when problems are predicted.

  2. Removing Strongly Adsorbed Surfactants and Capping Agents from

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanostructures - Energy Innovation Portal Industrial Technologies Industrial Technologies Advanced Materials Advanced Materials Find More Like This Return to Search Removing Strongly Adsorbed Surfactants and Capping Agents from Nanostructures Brookhaven National Laboratory Contact BNL About This Technology Technology Marketing Summary During production, nanostructures are often capped by surfactants or other capping agents to keep them from agglomerating. These moieties often interfere with

  3. Swarming behaviors in multi-agent systems with nonlinear dynamics

    SciTech Connect (OSTI)

    Yu, Wenwu; School of Electrical and Computer Engineering, RMIT University, Melbourne VIC 3001 ; Chen, Guanrong; Cao, Ming; L, Jinhu; Zhang, Hai-Tao

    2013-12-15

    The dynamic analysis of a continuous-time multi-agent swarm model with nonlinear profiles is investigated in this paper. It is shown that, under mild conditions, all agents in a swarm can reach cohesion within a finite time, where the upper bounds of the cohesion are derived in terms of the parameters of the swarm model. The results are then generalized by considering stochastic noise and switching between nonlinear profiles. Furthermore, swarm models with limited sensing range inducing changing communication topologies and unbounded repulsive interactions between agents are studied by switching system and nonsmooth analysis. Here, the sensing range of each agent is limited and the possibility of collision among nearby agents is high. Finally, simulation results are presented to demonstrate the validity of the theoretical analysis.

  4. AFECS. Multi-Agent Framework for Experiment Control Systems

    SciTech Connect (OSTI)

    Vardan Gyurjyan; David Abbott; William Heyes; Edward Jastrzembski; Carl Timmer; Elliott Wolin

    2008-01-23

    AFECS is a pure Java based software framework for designing and implementing distributed control systems. AFECS creates a control system environment as a collection of software agents behaving as finite state machines. These agents can represent real entities, such as hardware devices, software tasks, or control subsystems. A special control oriented ontology language (COOL), based on RDFS (Resource Definition Framework Schema) is provided for control system description as well as for agent communication. AFECS agents can be distributed over a variety of platforms. Agents communicate with their associated physical components using range of communication protocols, including tcl-DP, cMsg (publish-subscribe communication system developed at Jefferson Lab), SNMP (simple network management protocol), EPICS channel access protocol and JDBC.

  5. Oxidizer gels for detoxification of chemical and biological agents

    DOE Patents [OSTI]

    Hoffman, Dennis M.; McGuire, Raymond R.

    2002-01-01

    A gel composition containing oxidizing agents and thickening or gelling agents is used to detoxify chemical and biological agents by application directly to a contaminated area. The gelling agent is a colloidal material, such as silica, alumina, or alumino-silicate clays, which forms a viscous gel that does not flow when applied to tilted or contoured surfaces. Aqueous or organic solutions of oxidizing agents can be readily gelled with less than about 30% colloidal material. Gel preparation is simple and suitable for field implementation, as the gels can be prepared at the site of decontamination and applied quickly and uniformly over an area by a sprayer. After decontamination, the residue can be washed away or vacuumed up for disposal.

  6. A New Method of Comparing Forcing Agents in Climate Models

    SciTech Connect (OSTI)

    Kravitz, Benjamin S.; MacMartin, Douglas; Rasch, Philip J.; Jarvis, Andrew

    2015-10-14

    We describe a new method of comparing different climate forcing agents (e.g., CO2, CH4, and solar irradiance) that avoids many of the ambiguities introduced by temperature-related climate feedbacks. This is achieved by introducing an explicit feedback loop external to the climate model that adjusts one forcing agent to balance another while keeping global mean surface temperature constant. Compared to current approaches, this method has two main advantages: (i) the need to define radiative forcing is bypassed and (ii) by maintaining roughly constant global mean temperature, the effects of state dependence on internal feedback strengths are minimized. We demonstrate this approach for several different forcing agents and derive the relationships between these forcing agents in two climate models; comparisons between forcing agents are highly linear in concordance with predicted functional forms. Transitivity of the relationships between the forcing agents appears to hold within a wide range of forcing. The relationships between the forcing agents obtained from this method are consistent across both models but differ from relationships that would be obtained from calculations of radiative forcing, highlighting the importance of controlling for surface temperature feedback effects when separating radiative forcing and climate response.

  7. Volttron: An Agent Platform for the Smart Grid

    SciTech Connect (OSTI)

    Haack, Jereme N.; Akyol, Bora A.; Carpenter, Brandon J.; Tews, Cody W.; Foglesong, Lance W.

    2013-05-06

    VOLLTRON platform enables the deployment of intelligent sensors and controllers in the smart grid and provides a stable, secure and flexible framework that expands the sensing and control capabilities. VOLTTRON platform provides services fulfilling the essential requirements of resource management and security for agent operation in the power grid. The facilities provided by the platform allow agent developers to focus on the implementation of their agent system and not on the necessary "plumbing' code. For example, a simple collaborative demand response application was written in less than 200 lines of Python.

  8. NISAC Agent-Based Laboratory for Economics | NISAC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NISACNISAC Agent-Based Laboratory for Economics content top NISAC Agent-Based Laboratory for Economics (N-ABLE(tm)) Posted by Admin on Mar 1, 2012 in | Comments 0 comments NISAC Agent-Based Laboratory for Economics (N-ABLE(tm)) NISAC has developed N-ABLE(tm) to assist federal decision makers in improving the security and resilience of the U.S. economy. N-ABLE(tm) is a large-scale microeconomic simulation tool that models the complex supply-chain, spatial market dynamics, and

  9. Biosecurity reference : CFR-listed agent and toxin summaries.

    SciTech Connect (OSTI)

    Barnett, Natalie Beth

    2003-09-01

    This reference document provides summary information on the animal, plant, zoonotic, and human pathogens and toxins regulated and categorized by 9 CFR 331 and 7 CFR 121, 'Agricultural Bioterrorism Protection Act of 2002; Possession, Use and Transfer of Biological Agents and Toxins,' and 42 CFR 73, 'Possession, Use, and Transfer of Select Agents and Toxins.' Summary information includes, at a minimum, a description of the agent and its associated symptoms; often additional information is provided on the diagnosis, treatment, geographic distribution, transmission, control and eradication, and impacts on public health.

  10. ORISE: Agents of Opportunity for Terrorism Continuing Medical Education

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Course Agents of Opportunity for Terrorism On-line CME Course on Toxic Radiological Materials, Toxic Industrial Chemicals, and Toxic Industrial Materials Dates Scheduled Available 24/7 online. Fees and Credits Course Credits Type Costs AoO-TRMs (REM) Agents of Opportunity Day One 6.00 enduring $94.50 AoO-TIMs (ACMT) Agents of Opportunity Day Two 5.50 enduring $87.00 The Oak Ridge Institute for Science and Education (ORISE) is accredited by the Accreditation Council for Continuing Medical

  11. Gallium and indium imaging agents. 2. Complexes of sulfonated catecholyamide sequestering agents

    SciTech Connect (OSTI)

    Pecoraro, V.L.; Wong, G.B.; Raymond, K.N.

    1982-06-01

    The solution equilibria for the reaction of Ga(III) and In(III) with the hexadentate ligands N, N', N''-tris(2,3-dihydroxy-5-sulfonatobenzoyl)-1,3,5-tris(aminomethyl)benzene (MECAMS) and N, N', N''-tris(2,3-dihydroxy-5-sulfonatobenzoyl)-1,5,10-triazadecane (3,4-LICAMS) and the bidentate catechol N,N-dimethyl-2,3-dihydroxy-5-sulfonatobenzamide (DMBS) have been determined on 0.1 M KNO/sub 3/ at 25/sup 0/C. Both Ga(III) and In(III) are coordinated by three catecholate groups at high pH and have formation constants of the order ..beta../sub 110/ = 10/sup 38/ M/sup -1/. As the acidity of the medium is increased, the metal complexes of the hexadentate sequestering agents undergo protonation reactions. For the determination of the nature of the protonated metal chelates, the stretching frequency of the amide carbonyl has been monitored in D/sub 2/O by Fourier transform infrared spectroscopy (FT IR). These data support a series of two one-proton steps to form a mixed salicylate-catecholate coordination about the metal ion. In the salicylate bonding mode the metal is bound through the ortho phenolic oxygen and the amide cabonyl whereas catecholate coordination is via the adjacent phenols. In contrast, protonation of the M/sup III/(DMBS)/sub 3/ complexes results in dissociation of a catechol moiety to form M/sup III/(DMBS)/sub 2/. The potential use of these compounds as tumor-imaging agents in cancer diagnosis is discussed, with specific attention to the role of the gallium transferrin complex.

  12. T-618: Debian update for exim4: Mail Transport Agent

    Broader source: Energy.gov [DOE]

    It was discovered that Exim, the default mail transport agent in Debian, uses DKIM data obtain from DNS directly in a format string, potentially allowing malicious mail senders to execute arbitrary code.

  13. Measuring the Transport of Siloxane-Based Mold Release Agents...

    Office of Scientific and Technical Information (OSTI)

    Measuring the Transport of Siloxane-Based Mold Release Agents In An Encapsulation Mold. Citation Details In-Document Search Title: Measuring the Transport of Siloxane-Based Mold ...

  14. NRC Notice: Antifreeze Agents in Fire Water Sprinkler Systems

    Energy Savers [EERE]

    were identified in NRC Information Notice (IN) 2015-02, Antifreeze Agents in Fire Water Sprinkler Systems, (http:pbadupws.nrc.govdocsML1432ML14323A 176.pdf). This IN was...

  15. Method and apparatus for enhanced detection of toxic agents

    DOE Patents [OSTI]

    Greenbaum, Elias; Rodriguez, Jr., Miguel; Wu, Jie Jayne; Qi, Hairong

    2013-10-01

    A biosensor based detection of toxins includes enhancing a fluorescence signal by concentrating a plurality of photosynthetic organisms in a fluid into a concentrated region using biased AC electro-osmosis. A measured photosynthetic activity of the photosynthetic organisms is obtained in the concentrated region, where chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. A presence of the chemical, biological and/or radiological agents or precursors thereof, is determined in the fluid based on the measured photosynthetic activity of the concentrated plurality of photosynthetic organisms. A lab-on-a-chip system is used for the concentrating step. The presence of agents is determined from feature vectors, obtained from processing a time dependent signal using amplitude statistics and/or time-frequency analysis, relative to a control signal. A linear discriminant method including support vector machine classification (SVM) is used to identify the agents.

  16. 3-hydroxy-2(1H)-pyridinone chelating agents

    DOE Patents [OSTI]

    Raymond, K.; Xu, J.

    1999-04-06

    Disclosed is a series of improved chelating agents and the chelates formed from these agents, which are highly effective upon both injection and oral administration. Several of the most effective are of low toxicity. These chelating agents incorporate within their structure 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted carbamoyl group ortho to the hydroxy group of the hydroxypyridinone ring. The electron-withdrawing carbamoyl group increases the acidity, as well as the chemical stability towards oxidation and reduction, of the hydroxypyridinones. In the metal complexes of the chelating agents, the amide protons form very strong hydrogen bonds with the adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. The terminal N-substituents provide a certain degree of lipophilicity to the 3,2-HOPO, increasing oral activity. 2 figs.

  17. 3-hydroxy-2(1H)-pyridinone chelating agents

    DOE Patents [OSTI]

    Raymond, Kenneth; Xu, Jide

    1999-01-01

    Disclosed is a series of improved chelating agents and the chelates formed from these agents, which are highly effective upon both injection and oral administration. Several of the most effective are of low toxicity. These chelating agents incorporate within their structure 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted carbamoyl group ortho to the hydroxy group of the hydroxypyridinone ring. The electron-withdrawing carbamoyl group increases the acidity, as well as the chemical stability towards oxidation and reduction, of the hydroxypyridinones. In the metal complexes of the chelating agents, the amide protons form very strong hydrogen bonds with the adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. The terminal N-substituents provide a certain degree of lipophilicity to the 3,2-HOPO, increasing oral activity.

  18. Detoxification of organophosphate nerve agents by bacterial phosphotriesterase

    SciTech Connect (OSTI)

    Ghanem, Eman; Raushel, Frank M. . E-mail: raushel@tamu.edu

    2005-09-01

    Organophosphates have been widely used as insecticides and chemical warfare agents. The health risks associated with these agents have necessitated the need for better detoxification and bioremediation tools. Bacterial enzymes capable of hydrolyzing the lethal organophosphate nerve agents are of special interest. Phosphotriesterase (PTE) isolated from the soil bacteria Pseudomonas diminuta displays a significant rate enhancement and substrate promiscuity for the hydrolysis of organophosphate triesters. Directed evolution and rational redesign of the active site of PTE have led to the identification of new variants with enhanced catalytic efficiency and stereoselectivity toward the hydrolysis of organophosphate neurotoxins. PTE has been utilized to protect against organophosphate poisoning in vivo. Biotechnological applications of PTE for detection and decontamination of insecticides and chemical warfare agents are developing into useful tools. In this review, the catalytic properties and potential applications of this remarkable enzyme are discussed.

  19. V-103: RSA Authentication Agent Lets Remote Users Bypass Authenticatio...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    issued a fix (7.1.2). Addthis Related Articles U-267: RSA Authentication Agent 7.1 for Microsoft Windows and RSA Authentication Client 3.5 Access Control Vulnerability...

  20. Kit for providing a technetium medical radioimaging agent

    DOE Patents [OSTI]

    Wildung, Raymond E.; Garland, Thomas R.; Li, Shu-Mei W.

    2000-01-01

    The present invention is directed toward a kit for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanella putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.

  1. Adaptive method with intercessory feedback control for an intelligent agent

    DOE Patents [OSTI]

    Goldsmith, Steven Y.

    2004-06-22

    An adaptive architecture method with feedback control for an intelligent agent provides for adaptively integrating reflexive and deliberative responses to a stimulus according to a goal. An adaptive architecture method with feedback control for multiple intelligent agents provides for coordinating and adaptively integrating reflexive and deliberative responses to a stimulus according to a goal. Re-programming of the adaptive architecture is through a nexus which coordinates reflexive and deliberator components.

  2. Trivalent chromium electrolyte and process employing reducing agents

    SciTech Connect (OSTI)

    Tomaszewski, T.W.

    1984-10-16

    An aqueous acidic trivalent chromium electrolyte and process for electrodepositing chromium platings comprising an electrolyte containing trivalent chromium ions, a complexing agent, halide ions, ammonium ions and a reducing agent comprising an ion selected from the group consisting of scandium, yttrium, lanthanum, titanium, zirconium, hafnium, molybdenum, arsenic, selenium, tellurium, cerium, uranium, and tin present in an amount effective to maintain the concentration of hexavalent chromium ions formed in the bath at a level at which satisfactory chromium electrodeposits are obtained.

  3. ARM - The Environmental Impacts of Agents for Change

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Impacts of Agents for Change Outreach Home Room News Publications Traditional Knowledge Kiosks Barrow, Alaska Tropical Western Pacific Site Tours Contacts Students Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans The Environmental Impacts of Agents for Change What Has Been Happening Over the Past Century? Here we can refer to the Second Assessment Report of the Intergovernmental Panel on Climate Change approved

  4. Intelligent Software Agents for Enhancing Sensor Networks Monitoring of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Changing Conditions - Energy Innovation Portal Energy Analysis Energy Analysis Find More Like This Return to Search Intelligent Software Agents for Enhancing Sensor Networks Monitoring of Changing Conditions Oak Ridge National Laboratory Contact ORNL About This Technology Technology Marketing SummaryIntelligent software agents developed by ORNL researchers can be used with sensor networks in distributed and centralized computing systems to enhance detection and response by sensors to

  5. Agent Model Development for Assessing Climate-Induced Geopolitical Instability.

    SciTech Connect (OSTI)

    Boslough, Mark B.; Backus, George A.

    2005-12-01

    We present the initial stages of development of new agent-based computational methods to generate and test hypotheses about linkages between environmental change and international instability. This report summarizes the first year's effort of an originally proposed three-year Laboratory Directed Research and Development (LDRD) project. The preliminary work focused on a set of simple agent-based models and benefited from lessons learned in previous related projects and case studies of human response to climate change and environmental scarcity. Our approach was to define a qualitative model using extremely simple cellular agent models akin to Lovelock's Daisyworld and Schelling's segregation model. Such models do not require significant computing resources, and users can modify behavior rules to gain insights. One of the difficulties in agent-based modeling is finding the right balance between model simplicity and real-world representation. Our approach was to keep agent behaviors as simple as possible during the development stage (described herein) and to ground them with a realistic geospatial Earth system model in subsequent years. This work is directed toward incorporating projected climate data--including various C02 scenarios from the Intergovernmental Panel on Climate Change (IPCC) Third Assessment Report--and ultimately toward coupling a useful agent-based model to a general circulation model.3

  6. Solid-water detoxifying reagents for chemical and biological agents

    DOE Patents [OSTI]

    Hoffman, Dennis M.; Chiu, Ing Lap

    2006-04-18

    Formation of solid-water detoxifying reagents for chemical and biological agents. Solutions of detoxifying reagent for chemical and biological agents are coated using small quantities of hydrophobic nanoparticles by vigorous agitation or by aerosolization of the solution in the presence of the hydrophobic nanoparticles to form a solid powder. For example, when hydrophobic fumed silica particles are shaken in the presence of IN oxone solution in approximately a 95:5-weight ratio, a dry powder results. The hydrophobic silica forms a porous coating of insoluble fine particles around the solution. Since the chemical or biological agent tends to be hydrophobic on contact with the weakly encapsulated detoxifying solution, the porous coating breaks down and the detoxifying reagent is delivered directly to the chemical or biological agent for maximum concentration at the point of need. The solid-water (coated) detoxifying solutions can be blown into contaminated ventilation ducting or other difficult to reach sites for detoxification of pools of chemical or biological agent. Once the agent has been detoxified, it can be removed by flushing the area with air or other techniques.

  7. Software with Mobile Agents for Peer-to-Peer Information Sharing...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of failure. To avoid potential sudden system collapse, researchers at ORNL developed a Java-based mobile agent information software called Knowledge Acquisition Ubiquitous Agent...

  8. Agent 2003 Conference on Challenges in Social Simulation

    SciTech Connect (OSTI)

    Margaret Clemmons, ed.

    2003-01-01

    Welcome to the Proceedings of the fourth in a series of agent simulation conferences cosponsored by Argonne National Laboratory and The University of Chicago. Agent 2003 is the second conference in which three Special Interest Groups from the North American Association for Computational Social and Organizational Science (NAACSOS) have been involved in planning the program--Computational Social Theory; Simulation Applications; and Methods, Toolkits and Techniques. The theme of Agent 2003, Challenges in Social Simulation, is especially relevant, as there seems to be no shortage of such challenges. Agent simulation has been applied with increasing frequency to social domains for several decades, and its promise is clear and increasingly visible. Like any nascent scientific methodology, however, it faces a number of problems or issues that must be addressed in order to progress. These challenges include: (1) Validating models relative to the social settings they are designed to represent; (2) Developing agents and interactions simple enough to understand but sufficiently complex to do justice to the social processes of interest; (3) Bridging the gap between empirically spare artificial societies and naturally occurring social phenomena; (4) Building multi-level models that span processes across domains; (5) Promoting a dialog among theoretical, qualitative, and empirical social scientists and area experts, on the one hand, and mathematical and computational modelers and engineers, on the other; (6) Using that dialog to facilitate substantive progress in the social sciences; and (7) Fulfilling the aspirations of users in business, government, and other application areas, while recognizing and addressing the preceding challenges. Although this list hardly exhausts the challenges the field faces, it does identify topics addressed throughout the presentations of Agent 2003. Agent 2003 is part of a much larger process in which new methods and techniques are applied to

  9. 3-hydroxy-2(1H)-pyridinone chelating agents

    DOE Patents [OSTI]

    Raymond, Kenneth N.; Xu, Jide

    1997-01-01

    Disclosed is a series of improved metal chelating agents, which are highly effective upon both injection and oral administration; several of the most effective are of low toxicity. These chelating agents incorporate within their structure 1-hydroxy-2-pyridinone (1,2-HOPO) and 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted carbamoyl group ortho to the hydroxy or oxo groups of the hydroxypyridinone ring. The electron-withdrawing carbamoyl group increases the acidity of the hydroxypyridinones. In the metal complexes of said chelating agents, the amide protons form very strong hydrogen bonds with its adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. The terminal N-substituents provides a certain degree of lipophilicity to said 3,2-HOPO, increasing oral activity. Also disclosed is a method of making the chelating agents and a method of producing a known compound, 3-hydroxy-1-alkyl-2(1H)pyridinone, used as a precursor to the chelating agent, safely and in large quantities.

  10. 3-hydroxy-2(1H)-pyridinone chelating agents

    DOE Patents [OSTI]

    Raymond, K.N.; Xu, J.

    1997-04-29

    Disclosed is a series of improved metal chelating agents, which are highly effective upon both injection and oral administration; several of the most effective are of low toxicity. These chelating agents incorporate within their structure 1-hydroxy-2-pyridinone (1,2-HOPO) and 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted carbamoyl group ortho to the hydroxy or oxo groups of the hydroxypyridinone ring. The electron-withdrawing carbamoyl group increases the acidity of the hydroxypyridinones. In the metal complexes of the chelating agents, the amide protons form very strong hydrogen bonds with its adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. The terminal N-substituents provides a certain degree of lipophilicity to the 3,2-HOPO, increasing oral activity. Also disclosed is a method of making the chelating agents and a method of producing a known compound, 3-hydroxy-1-alkyl-2(1H)pyridinone, used as a precursor to the chelating agent, safely and in large quantities. 2 figs.

  11. Decontamination of biological warfare agents by a microwave plasma torch

    SciTech Connect (OSTI)

    Lai, Wilson; Lai, Henry; Kuo, Spencer P.; Tarasenko, Olga; Levon, Kalle

    2005-02-01

    A portable arc-seeded microwave plasma torch running stably with airflow is described and applied for the decontamination of biological warfare agents. Emission spectroscopy of the plasma torch indicated that this torch produced an abundance of reactive atomic oxygen that could effectively oxidize biological agents. Bacillus cereus was chosen as a simulant of Bacillus anthracis spores for biological agent in the decontamination experiments. Decontamination was performed with the airflow rate of 0.393 l/s, corresponding to a maximum concentration of atomic oxygen produced by the torch. The experimental results showed that all spores were killed in less than 8 s at 3 cm distance, 12 s at 4 cm distance, and 16 s at 5 cm distance away from the nozzle of the torch.

  12. Air monitoring and detection of chemical and biological agents

    SciTech Connect (OSTI)

    Leonelli, J.; Althouse, M.L.

    1999-06-01

    This volume contains the proceedings of SPIE`s remote sensing symposium which was held November 2--3, 1998 in Boston, Massachusetts. Topics of discussion include the following: system simulations, atmospheric modeling, and performance prediction studies of chemical warfare remote sensing technologies; ultraviolet laser-induced fluorescence and aerosol detection methods for remote sensing of biological warfare agents; passive detection methods for remote detection of chemical warfare agents; and lidar-based system performance assessments, demonstrations, and new concepts for chemical warfare/biological warfare detection.

  13. Method and apparatus for enhanced detection of toxic agents

    DOE Patents [OSTI]

    Greenbaum, Elias; Rodriguez, Jr., Miguel; Wu, Jie Jayne; Qi, Hairong

    2012-06-12

    A water quality analyzer for real-time detection according to the invention comprises a biased AC electro-osmosis (ACEO) cell for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region, wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.

  14. An agent-based tool for infrastructure interdependency policy analysis.

    SciTech Connect (OSTI)

    North, M. J.

    2000-12-14

    Complex Adaptive Systems (CAS) can be applied to investigate complex infrastructure interdependencies such as those between the electric power and natural gas markets. These markets are undergoing fundamental transformations including major changes in electric generator fuel sources. Electric generators that use natural gas as a fuel source are rapidly gaining market share. These generators introduce direct interdependency between the electric power and natural gas markets. These interdependencies have been investigated using the emergent behavior of CAS model agents within the Spot Market Agent Research Tool Version 2.0 Plus Natural Gas (SMART II+).

  15. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent A Key Enzyme to the Potency of an Anticancer Agent Print Wednesday, 28 May 2008 00:00 Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid

  16. 4-haloethenylphenyl tropane:serotonin transporter imaging agents

    DOE Patents [OSTI]

    Goodman, Mark M.; Martarello, Laurent

    2005-01-18

    A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.

  17. HOW TO CREATE A SEARCH AGENT IN YOUR USAJOBS ACCOUNT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HOW TO CREATE A SEARCH AGENT IN YOUR USAJOBS ACCOUNT Why spend hours searching for your ideal job. Make the USAJOBS website do all the work for you by creating a Search Agent! STEP 1: Log into your USAJOBS "My Account" and select "Saved Searches." STEP 2: Select the "Create a new saved search" button. STEP 3: Select all jobs in the Richland, WA area. NOTE: that you can create up to 10 saved searches and they'll search around the clock and e-mail you the results!

  18. Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents

    DOE Patents [OSTI]

    Davison, Alan; Brenner, David; Lister-James, John; Jones, Alun G.

    1987-06-16

    A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the kidney for diagnosis of kidney disfunction.

  19. Isonitrile radionuclide complexes for labelling and imaging agents

    DOE Patents [OSTI]

    Jones, Alun G.; Davison, Alan; Abrams, Michael J.

    1984-06-04

    A coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.

  20. Dimensions of Usability: Cougaar, Aglets and Adaptive Agent Architecture (AAA)

    SciTech Connect (OSTI)

    Haack, Jereme N.; Cowell, Andrew J.; Gorton, Ian

    2004-06-20

    Research and development organizations are constantly evaluating new technologies in order to implement the next generation of advanced applications. At Pacific Northwest National Laboratory, agent technologies are perceived as an approach that can provide a competitive advantage in the construction of highly sophisticated software systems in a range of application areas. An important factor in selecting a successful agent architecture is the level of support it provides the developer in respect to developer support, examples of use, integration into current workflow and community support. Without such assistance, the developer must invest more effort into learning instead of applying the technology. Like many other applied research organizations, our staff are not dedicated to a single project and must acquire new skills as required, underlining the importance of being able to quickly become proficient. A project was instigated to evaluate three candidate agent toolkits across the dimensions of support they provide. This paper reports on the outcomes of this evaluation and provides insights into the agent technologies evaluated.

  1. Tissue-based standoff biosensors for detecting chemical warfare agents

    DOE Patents [OSTI]

    Greenbaum, Elias; Sanders, Charlene A.

    2003-11-18

    A tissue-based, deployable, standoff air quality sensor for detecting the presence of at least one chemical or biological warfare agent, includes: a cell containing entrapped photosynthetic tissue, the cell adapted for analyzing photosynthetic activity of the entrapped photosynthetic tissue; means for introducing an air sample into the cell and contacting the air sample with the entrapped photosynthetic tissue; a fluorometer in operable relationship with the cell for measuring photosynthetic activity of the entrapped photosynthetic tissue; and transmitting means for transmitting analytical data generated by the fluorometer relating to the presence of at least one chemical or biological warfare agent in the air sample, the sensor adapted for deployment into a selected area.

  2. System configured for applying multiple modifying agents to a substrate

    DOE Patents [OSTI]

    Propp, W. Alan; Argyle, Mark D.; Janikowski, Stuart K.; Fox, Robert V.; Toth, William J.; Ginosar, Daniel M.; Allen, Charles A.; Miller, David L.

    2003-11-25

    The present invention is related to the modifying of substrates with multiple modifying agents in a single continuous system. At least two processing chambers are configured for modifying the substrate in a continuous feed system. The processing chambers can be substantially isolated from one another by interstitial seals. Additionally, the two processing chambers can be substantially isolated from the surrounding atmosphere by end seals. Optionally, expansion chambers can be used to separate the seals from the processing chambers.

  3. System Configured For Applying Multiple Modifying Agents To A Substrate.

    DOE Patents [OSTI]

    Propp, W. Alan; Argyle, Mark D.; Janikowski, Stuart K.; Fox, Robert V.; Toth, William J.; Ginosar, Daniel M.; Allen, Charles A.; Miller, David L.

    2005-11-08

    The present invention is related to the modifying of substrates with multiple modifying agents in a single continuous system. At least two processing chambers are configured for modifying the substrate in a continuous feed system. The processing chambers can be substantially isolated from one another by interstitial seals. Additionally, the two processing chambers can be substantially isolated from the surrounding atmosphere by end seals. Optionally, expansion chambers can be used to separate the seals from the processing chambers.

  4. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  5. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  6. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  7. A Key Enzyme to the Potency of an Anticancer Agent

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Key Enzyme to the Potency of an Anticancer Agent Print Incorporation of halogen atoms into drug molecules often increases biological activity. This is the case with salinosporamide A (sal A), a natural product from the marine bacterium Salinispora tropica that is 500 times more active than sal B, its nonchlorinated analog. Sal A is in phase I human clinical trials for the treatment of multiple myeloma and solid tumors. A group of researchers, using diffraction data collected at ALS Beamline

  8. Visual agent-based model development with repast simphony.

    SciTech Connect (OSTI)

    North, M. J.; Tatara, E.; Collier, N. T.; Ozik, J.; Decision and Information Sciences; Univ. of Chicago; PantaRei Corp.

    2007-01-01

    Repast is a widely used, free, and open-source agent-based modeling and simulation toolkit. Three Repast platforms are currently available, each of which has the same core features but a different environment for these features. Repast Simphony (Repast S) extends the Repast portfolio by offering a new approach to simulation development and execution. This paper presents a model of physical infrastructure network interdependency as an introductory tutorial and illustration of the visual modeling capabilities of Repast S.

  9. Carbonyl sulfide: potential agent of atmospheric sulfur corrosion

    SciTech Connect (OSTI)

    Graedel, T.E.; Kammlott, G.W.; Franey, J.P.

    1981-05-08

    Laboratory exposure experiments demonstrate that carbonyl sulfide in wet air corrodes copper at 22/sup 0/C at a rate that is approximately linear with total exposure (the product of exposure time and carbonyl sulfide concentration). The corrosion rate is similar to that of hydrogen sulfide, a widely recognized corrodant. The much greater average atmospheric abundance of carbonyl sulfide compared with that of hydrogen sulfide or sulfur dioxide suggests that carbonyl sulfide may be a major agent of atmospheric sulfur corrosion.

  10. Enhanced Detection of Toxic Agents - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hydropower, Wave and Tidal Hydropower, Wave and Tidal Energy Analysis Energy Analysis Advanced Materials Advanced Materials Find More Like This Return to Search Enhanced Detection of Toxic Agents Oak Ridge National Laboratory Contact ORNL About This Technology Publications: PDF Document Publication 12-G00200_1549.pdf (672 KB) Technology Marketing SummaryResearchers at ORNL and the University of Tennessee have taken the next step in the development of their AquaSentinel water quality monitoring

  11. Resilient Control System Execution Agent (ReCoSEA)

    SciTech Connect (OSTI)

    Craig G. Rieger; Kris Villez

    2012-08-01

    In an increasingly networked world, critical infrastructure systems suffer from two types of vulnerability. The first is the traditionally recognized problem of monitoring the systems for faults and failures, recognizing and analyzing data, and responding with real understanding to the problems of the system. Increasingly complex systems create the opportunity for single points of failure to cascade when inaccurate assessment of system health increases response time or leads to faulty analysis of the problems involved. A second problem involves vulnerability to cyber intrusion, in which bad actors can mask system deterioration or present false data about system status. A resilient system will protect stability, efficiency, and security. To ensure these three states, the system must react to changing conditions within the system with coordination: no one component of the system can be allowed to react to problems without real consideration of the effects of that action on other components within the system. Systems with multi-agent design typically have three layers of action, a management layer, a coordination layer, and an execution layer. A resilient multi-agent system will emphasize functions of the execution layer, which has the responsibility of initiating actions, monitoring, analyzing, and controlling its own processes, while feeding information back to the higher levels of management and coordination. The design concept of a resilient control system execution agent (ReCoSEA) grows out of these underpinnings, and through the use of computational intelligence techniques, this paper suggests an associated design methodology.

  12. Mercury removal in utility wet scrubber using a chelating agent

    DOE Patents [OSTI]

    Amrhein, Gerald T.

    2001-01-01

    A method for capturing and reducing the mercury content of an industrial flue gas such as that produced in the combustion of a fossil fuel or solid waste adds a chelating agent, such as ethylenediaminetetraacetic acid (EDTA) or other similar compounds like HEDTA, DTPA and/or NTA, to the flue gas being scrubbed in a wet scrubber used in the industrial process. The chelating agent prevents the reduction of oxidized mercury to elemental mercury, thereby increasing the mercury removal efficiency of the wet scrubber. Exemplary tests on inlet and outlet mercury concentration in an industrial flue gas were performed without and with EDTA addition. Without EDTA, mercury removal totaled 42%. With EDTA, mercury removal increased to 71%. The invention may be readily adapted to known wet scrubber systems and it specifically provides for the removal of unwanted mercury both by supplying S.sup.2- ions to convert Hg.sup.2+ ions into mercuric sulfide (HgS) and by supplying a chelating agent to sequester other ions, including but not limited to Fe.sup.2+ ions, which could otherwise induce the unwanted reduction of Hg.sup.2+ to the form, Hg.sup.0.

  13. Agent based control of power systems, ForskEL (Smart Grid Project...

    Open Energy Info (EERE)

    Agent based control of power systems, ForskEL (Smart Grid Project) Jump to: navigation, search Project Name Agent based control of power systems, ForskEL Country Denmark...

  14. Method for tracking the location of mobile agents using stand-off detection technique

    DOE Patents [OSTI]

    Schmitt, Randal L.; Bender, Susan Fae Ann; Rodacy, Philip J.; Hargis, Jr., Philip J.; Johnson, Mark S.

    2006-12-26

    A method for tracking the movement and position of mobile agents using light detection and ranging (LIDAR) as a stand-off optical detection technique. The positions of the agents are tracked by analyzing the time-history of a series of optical measurements made over the field of view of the optical system. This provides a (time+3-D) or (time+2-D) mapping of the location of the mobile agents. Repeated pulses of a laser beam impinge on a mobile agent, such as a bee, and are backscattered from the agent into a LIDAR detection system. Alternatively, the incident laser pulses excite fluorescence or phosphorescence from the agent, which is detected using a LIDAR system. Analysis of the spatial location of signals from the agents produced by repeated pulses generates a multidimensional map of agent location.

  15. U-208: HP Operations Agent Bugs Let Remote Users Execute Arbitrary Code

    Broader source: Energy.gov [DOE]

    Two vulnerabilities were reported in HP Operations Agent. A remote user can execute arbitrary code on the target system

  16. Methods to radiolabel natural organic matter by reduction with hydrogen labeled reducing agents

    DOE Patents [OSTI]

    Tinnacher, Ruth M.; Honeyman, Bruce D.

    2011-10-18

    Methods to radiolabel natural organic matter by reduction with a hydrogen labeled reducing agent, and compositions, are provided.

  17. Y-12's Cothron recognized as a change agent | Y-12 National Security

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Complex 's Cothron recognized ... Y-12's Cothron recognized as a change agent Posted: September 1, 2016 - 11:08am Y-12 environmental compliance manager Terry Cothron won the NNSA Sustainability Award in the Change Agent category. Terry Cothron is considered one of the founding fathers of the environmental program at Y-12. This year, his tremendous efforts were acknowledged as he received the change agent award as part of the NNSA Sustainability Awards. The change agent award recognizes

  18. Agent Concept for Intelligent Distributed Coordination in the Electric Power Grid

    SciTech Connect (OSTI)

    SMATHERS, DOUGLAS C.; GOLDSMITH, STEVEN Y.

    2001-03-01

    Intelligent agents and multi-agent systems promise to take information management for real-time control of the power grid to a new level. This report presents our concept for intelligent agents to mediate and coordinate communications between Control Areas and Security Coordinators for real-time control of the power grid. An appendix describes the organizations and publications that deal with agent technologies.

  19. Investigation of oil recovery improvement by coupling an interfacial tension agent and a mobility control agent in light oil reservoirs. Technical progress report, October--December 1994

    SciTech Connect (OSTI)

    Pitts, M.J.

    1994-01-01

    The study will investigate two major areas concerning co-injecting an interfacial tension reduction agent(s) and a mobility control agent into petroleum reservoirs. The first will consist of defining the mechanisms of interaction of an alkaline agent, a surfactant, and a polymer on a fluid-fluid and a fluid-rock basis. The second is the improvement of the economics of the combined technology. This report examines effect of rock type on oil recovery by an alkaline-surfactant-polymer solutions. This report also begins a series of evaluations to improve the economics of alkaline-surfactant-polymer oil recovery.

  20. Developing the Manufacturing Process for Hylene MP Curing Agent

    SciTech Connect (OSTI)

    Eastwood, Eric

    2009-02-16

    This report details efforts to scale-up and re-establish the manufacturing process for the curing agent known as Hylene MP. First, small scale reactions were completed with varying conditions to determine key drivers for yielding high quality product. Once the optimum conditions were determined on the small scale, the scaled-up process conditions were determined. New equipment was incorporated into the manufacturing process to create a closed production system and improve chemical exposure controls and improve worker safety. A safe, efficient manufacturing process was developed to manufacture high quality Hylene MP in large quantities.

  1. ECCENTRIC ROLLING OF POWDER AND BONDING AGENT INTO SPHERICAL PELLETS

    DOE Patents [OSTI]

    Patton, G. Jr.; Zirinsky, S.

    1961-06-01

    A machine is described for pelletizing powder and bonding agent into spherical pellets of high density and uniform size. In this device, the material to be compacted is added to a flat circular pan which is moved in a circular orbit in a horizontal plane about an axis displaced from that of the pan's central axis without rotating the pan about its central axis. This movement causes the material contained therein to roll around the outside wall of the container and build up pellets of uniform shape, size, and density.

  2. SEQUESTERING AGENTS FOR ACTIVE CAPS - REMEDIATION OF METALS AND ORGANICS

    SciTech Connect (OSTI)

    Knox, A; Michael Paller, M; Danny D. Reible, D; Xingmao Ma, X; Ioana G. Petrisor, I

    2007-05-10

    This research evaluated organoclays, zeolites, phosphates, and a biopolymer as sequestering agents for inorganic and organic contaminants. Batch experiments were conducted to identify amendments and mixtures of amendments for metal and organic contaminants removal and retention. Contaminant removal was evaluated by calculating partitioning coefficients. Metal retention was evaluated by desorption studies in which residue from the removal studies was extracted with 1 M MgCl{sub 2} solution. The results indicated that phosphate amendments, some organoclays, and the biopolymer, chitosan, were very effective sequestering agents for metals in fresh and salt water. Organoclays were very effective sorbents for phenanthrene, pyrene, and benzo(a)pyrene. Partitioning coefficients for the organoclays were 3000-3500 ml g{sup -1} for benzo(a)pyrene, 400-450 ml g{sup -1} for pyrene, and 50-70 ml g{sup -1} for phenanthrene. Remediation of sites with a mixture of contaminants is more difficult than sites with a single contaminant because metals and organic contaminants have different fate and transport mechanisms in sediment and water. Mixtures of amendments (e.g., organoclay and rock phosphate) have high potential for remediating both organic and inorganic contaminants under a broad range of environmental conditions, and have promise as components in active caps for sediment remediation.

  3. Easy Energy Tips for Apartments or Rental Homes | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Warm your home during the day by leaving the curtains on sun-facing windows open. Over the last few weeks we've talked about things like energy audits and energy-saving incentives, ...

  4. Release of organic chelating agents from solidified decontamination wastes

    SciTech Connect (OSTI)

    Piciulo, P.L.; Adams, J.W.; Milian, L.W.

    1986-01-01

    In order to provide technical information needed by the US Nuclear Regulatory Commission to evaluate the adequacy of near-surface disposal of decontamination wastes, Brookhaven National Laboratory has measured the release of organic complexing agents from simulated decontamination resin wastes solidified in cement and vinyl ester-styrene. The simulated waste consisted of either mixed bed ion-exchange resins or anion exchange resins equilibrated with EDTA, oxalic acid, citric acid, picolinic acid, formic acid, simulated LOMI reagent or the LND-101A decontamination reagent. The standard procedure ANS 16.1 appeared to be adequate for determining a leachability index for organic acids for comparing the leach resistance of decontamination waste forms. Leachability indexes appeared to be specific for each organic acid. Further, the apparent diffusivities were generally less than those observed for Cs releases from cement wastes forms. The finder material and the composition of the simulated wastes affected the release of the reagents.

  5. Multi-agent cooperative systems applied to precision applications

    SciTech Connect (OSTI)

    McKay, M.D.; Anderson, M.O.; Gunderson, R.W.; Flann, N.; Abbott, B.

    1998-03-01

    Regulatory agencies are imposing limits and constraints to protect the operator and/or the environment. While generally necessary, these controls also tend to increase cost and decrease efficiency and productivity. Intelligent computer systems can be made to perform these hazardous tasks with greater efficiency and precision without danger to the operators. The Idaho national Engineering and Environmental Laboratory and the Center for Self-Organizing and Intelligent Systems at Utah State University have developed a series of autonomous all-terrain multi-agent systems capable of performing automated tasks within hazardous environments. This paper discusses the development and application of cooperative small-scale and large-scale robots for use in various activities associated with radiologically contaminated areas, prescription farming, and unexploded ordinances.

  6. Additive agent for zinc alloy electrolyte and process

    SciTech Connect (OSTI)

    Bammel, B.D.

    1986-07-01

    An aqueous acidic electrolyte is described suitable for electrodepositing zinc alloys on a substrate comprising zinc ions and at least one additional metal ion selected from the group consisting nickel, cobalt, iron and mixtures thereof present in an amount sufficient to electrodeposit a zinc alloy, and, for providing improved grain-refinement and enhancing the codeposition of the alloying metals in the zinc alloy deposit. An effective amount of an additive agent consists of a bath-soluble anionic carboxylated polyoxyalkylene compound derived from the carboxylation of: (a) the polymerization of alkylene oxides selected from the group consisting of ethylene oxide, propylene oxide, glycidol, butylene oxide and mixtures thereof; and (b) the alkoxylation of mono and polyhydroxy compounds selected from the group consisting of hydroxyl containing alkyl, alkenyl, alkynyl, aryl, as well as mixtures thereof.

  7. Engineered plant biomass particles coated with biological agents

    DOE Patents [OSTI]

    Dooley, James H.; Lanning, David N.

    2014-06-24

    Plant biomass particles coated with a biological agent such as a bacterium or seed, characterized by a length dimension (L) aligned substantially parallel to a grain direction and defining a substantially uniform distance along the grain, a width dimension (W) normal to L and aligned cross grain, and a height dimension (H) normal to W and L. In particular, the L.times.H dimensions define a pair of substantially parallel side surfaces characterized by substantially intact longitudinally arrayed fibers, the W.times.H dimensions define a pair of substantially parallel end surfaces characterized by crosscut fibers and end checking between fibers, and the L.times.W dimensions define a pair of substantially parallel top and bottom surfaces.

  8. Engineered plant biomass particles coated with bioactive agents

    DOE Patents [OSTI]

    Dooley, James H; Lanning, David N

    2013-07-30

    Plant biomass particles coated with a bioactive agent such as a fertilizer or pesticide, characterized by a length dimension (L) aligned substantially parallel to a grain direction and defining a substantially uniform distance along the grain, a width dimension (W) normal to L and aligned cross grain, and a height dimension (H) normal to W and L. In particular, the L.times.H dimensions define a pair of substantially parallel side surfaces characterized by substantially intact longitudinally arrayed fibers, the W.times.H dimensions define a pair of substantially parallel end surfaces characterized by crosscut fibers and end checking between fibers, and the L.times.W dimensions define a pair of substantially parallel top and bottom surfaces.

  9. Laser-induced fluorescence-cued, laser-induced breakdown spectroscopy biological-agent detection

    SciTech Connect (OSTI)

    Hybl, John D.; Tysk, Shane M.; Berry, Shaun R.; Jordan, Michael P

    2006-12-01

    Methods for accurately characterizing aerosols are required for detecting biological warfare agents. Currently, fluorescence-based biological agent sensors provide adequate detection sensitivity but suffer from high false-alarm rates. Combining single-particle fluorescence analysis with laser-induced breakdown spectroscopy (LIBS) provides additional discrimination and potentially reduces false-alarm rates. A transportable UV laser-induced fluorescence-cued LIBS test bed has been developed and used to evaluate the utility of LIBS for biological-agent detection. Analysis of these data indicates that LIBS adds discrimination capability to fluorescence-based biological-agent detectors.However, the data also show that LIBS signatures of biological agent simulants are affected by washing. This may limit the specificity of LIBS and narrow the scope of its applicability in biological-agent detection.

  10. Estimated Chemical Warfare Agent Surface Clearance Goals for Remediation Pre-Planning

    SciTech Connect (OSTI)

    Dolislager, Frederick; Bansleben, Dr. Donald; Watson, Annetta Paule

    2010-01-01

    Health-based surface clearance goals, in units of mg/cm2, have been developed for the persistent chemical warfare agents sulfur mustard (HD) and nerve agent VX as well as their principal degradation products. Selection of model parameters and critical receptor (toddler child) allow calculation of surface residue estimates protective for the toddler child, the general population and adult employees of a facilty that has undergone chemical warfare agent attack.

  11. Temporary Bridging Agents for Use in Drilling and Completions of EGS |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Temporary Bridging Agents for Use in Drilling and Completions of EGS Temporary Bridging Agents for Use in Drilling and Completions of EGS DOE Geothermal Peer Review 2010 - Presentation. Project objectives: Develop materials or systems that bridge to seal or divert flow from fractures existing while drilling EGS wells or in injection formation and that eventually decompose thereby leaving the fractures unsealed and undamaged. specialized_watters_bridging_agents.pdf

  12. T-560: Cisco Security Advisory: Management Center for Cisco Security Agent Remote Code Execution Vulnerability

    Broader source: Energy.gov [DOE]

    The Management Center for Cisco Security Agent is affected by a vulnerability that may allow an unauthenticated attacker to perform remote code execution on the affected device.

  13. U-267: RSA Authentication Agent 7.1 for Microsoft Windows...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    RSA Authentication Agent Lets Remote Authenticated Users Bypass an Authentication Step reference LINKS: SecurityTracker Alert ID: 1027559 Bugtraq ID: 55662 CVE-2012-2287...

  14. V-223: RSA Authentication Agent for PAM Allows Remote Users to...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    has issued a fix Addthis Related Articles U-267: RSA Authentication Agent 7.1 for Microsoft Windows and RSA Authentication Client 3.5 Access Control Vulnerability...

  15. V-159: RSA SecurID Agent Discloses Node Secret Encryption Key...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    has issued fixes. Addthis Related Articles U-267: RSA Authentication Agent 7.1 for Microsoft Windows and RSA Authentication Client 3.5 Access Control Vulnerability...

  16. Bioforensics: Characterization of biological weapons agents by NanoSIMS

    SciTech Connect (OSTI)

    Weber, P K; Ghosal, S; Leighton, T J; Wheeler, K E; Hutcheon, I D

    2007-02-26

    The anthrax attacks of Fall 2001 highlight the need to develop forensic methods based on multiple identifiers to determine the origin of biological weapons agents. Genetic typing methods (i.e., DNA and RNA-based) provide one attribution technology, but genetic information alone is not usually sufficient to determine the provenance of the material. Non-genetic identifiers, including elemental and isotopic signatures, provide complementary information that can be used to identify the means, geographic location and date of production. Under LDRD funding, we have successfully developed the techniques necessary to perform bioforensic characterization with the NanoSIMS at the individual spore level. We have developed methods for elemental and isotopic characterization at the single spore scale. We have developed methods for analyzing spore sections to map elemental abundance within spores. We have developed rapid focused ion beam (FIB) sectioning techniques for spores to preserve elemental and structural integrity. And we have developed a high-resolution depth profiling method to characterize the elemental distribution in individual spores without sectioning. We used these newly developed methods to study the controls on elemental abundances in spores, characterize the elemental distribution of in spores, and to study elemental uptake by spores. Our work under this LDRD project attracted FBI and DHS funding for applied purposes.

  17. Protein interaction reporter agents and methods for using same

    DOE Patents [OSTI]

    Bruce, James E.; Tang, Xiaoting; Munske,Gerhard

    2009-04-28

    Particular aspects provide novel protein interaction reporter (PIR) compounds (e.g., formulas I and II), comprising at least two protein reactive moieties (e.g., N-hydroxysuccinamide), each linked to a reporter moiety (e.g., mass reporter) by a covalent labile bond that is differentially cleavable with respect to peptide bonds (e.g., by a method such as collisional activation in a mass spectrometer, activation by electron capture dissociation (ECD), photoactivation, etc.), wherein the reporter moiety is operatively releasable from the PIR agent upon cleavage of the labile bonds, the released reporter moiety having a characteristic identifying property or label (e.g., m/z value). Particular PIRs comprise a mass reporter moiety, and further comprise an affinity group, (e.g., biotin), linked to the PIR (e.g., to the mass reporter moiety) by a selectively cleavable bone (e.g. photo-labile bond)). Additional aspects provide methods for characterizing intermolecular or intramolecular protein interactions using one or more inventive PIR compounds.

  18. Agent-Based Knowledge Discovery for Modeling and Simulation

    SciTech Connect (OSTI)

    Haack, Jereme N.; Cowell, Andrew J.; Marshall, Eric J.; Fligg, Alan K.; Gregory, Michelle L.; McGrath, Liam R.

    2009-09-15

    This paper describes an approach to using agent technology to extend the automated discovery mechanism of the Knowledge Encapsulation Framework (KEF). KEF is a suite of tools to enable the linking of knowledge inputs (relevant, domain-specific evidence) to modeling and simulation projects, as well as other domains that require an effective collaborative workspace for knowledge-based tasks. This framework can be used to capture evidence (e.g., trusted material such as journal articles and government reports), discover new evidence (covering both trusted and social media), enable discussions surrounding domain-specific topics and provide automatically generated semantic annotations for improved corpus investigation. The current KEF implementation is presented within a semantic wiki environment, providing a simple but powerful collaborative space for team members to review, annotate, discuss and align evidence with their modeling frameworks. The novelty in this approach lies in the combination of automatically tagged and user-vetted resources, which increases user trust in the environment, leading to ease of adoption for the collaborative environment.

  19. Modeling Dispersion of Chemical-Biological Agents in Three Dimensional Living Space

    SciTech Connect (OSTI)

    William S. Winters

    2002-02-01

    This report documents a series of calculations designed to demonstrate Sandia's capability in modeling the dispersal of chemical and biological agents in complex three-dimensional spaces. The transport of particles representing biological agents is modeled in a single room and in several connected rooms. The influence of particle size, particle weight and injection method are studied.

  20. A New F-18 Labeled PET Agent For Imaging Alzheimer's Plaques

    SciTech Connect (OSTI)

    Kulkarni, Padmakar V.; Hao Guiyang; Arora, Veera; Long, Michael; Slavine, Nikolai; Chiguru, Srinivas; Qu Baoxi; Sun Xiankai; Bennett, Michael; Antich, Peter P.; Bonte, Frederick J.; Vasdev, Neil

    2011-06-01

    Amyloid plaques and neurofibrillary tangles are hallmarks of Alzheimer's disease (AD). Advances in development of imaging agents have focused on targeting amyloid plaques. Notable success has been the development of C-11 labeled PIB (Pittsburgh Compound) and a number of studies have demonstrated the utility of this agent. However, the short half life of C-11 (t1/2: 20 min), is a limitation, thus has prompted the development of F-18 labeled agents. Most of these agents are derivatives of amyloid binding dyes; Congo red and Thioflavin. Some of these agents are in clinical trials with encouraging results. We have been exploring new class of agents based on 8-hydroxy quinoline, a weak metal chelator, targeting elevated levels of metals in plaques. Iodine-123 labeled clioquinol showed affinity for amyloid plaques however, it had limited brain uptake and was not successful in imaging in intact animals and humans. We have been successful in synthesizing F-18 labeled 8-hydroxy quinoline. Small animal PET/CT imaging studies with this agent showed high (7-10% ID/g), rapid brain uptake and fast washout of the agent from normal mice brains and delayed washout from transgenic Alzheimer's mice. These promising results encouraged us in further evaluation of this class of compounds for imaging AD plaques.

  1. Hydrogen Generation Rate Scoping Study of DOW Corning Antifoam Agent

    SciTech Connect (OSTI)

    Crawford, Charles

    2005-09-27

    The antifoam agent DOW Corning Q2-3183A will be added to waste streams in the Hanford River Protection Program-Waste Treatment and Immobilization Plant (RPP-WTP) to prevent foaming. It consists mostly of polydimethylsiloxane (PDMS) and polypropylene glycol (PPG). These and other minor constituents of the antifoam have organic constituents that may participate in radiolytic and chemical reactions that produce hydrogen in Hanford waste. It has been recommended by The WTP R&T Department recommended personnel to treat the organic compounds of the antifoam like the in a similar manner as other organic compounds that are native to the Hanford waste with respect to hydrogen production. This testing has investigated the radiolytic and thermal production of hydrogen from antifoam added to simulant waste solutions to determine if the organic components of the antifoam produce hydrogen in the same manner as the native organic species in Hanford waste. Antifoam additions for this testing were in the range of 4 to 10 wt% to ensure adequate hydrogen detection. Test conditions were selected to bound exposures to the antifoam agent in the WTP. These levels are higher than previously recommended values of 350 mg/L for actual applications in WTP tanks containing air spargers and pulse jet mixers. Limited degradation analyses for the organic components of the antifoam were investigated in this study. A more detailed study involving analyses of antifoam degradation and product formation is in progress at SRNL and results from that study will be reported at a later time. The total organic carbon (TOC) content of the Q2-3183A antifoam was measured to be 39.7 {+-} 4.9 wt% TOC. This measurement was performed in triplicate with on three different dilutions of the pure antifoam liquid using a TOC combustion analyzer instrument with catalytic oxidation, followed by CO{sub 2} quantification using an infrared detector. Test results from this study indicate that the WTP HGR correlation

  2. Mercury Control with Calcium-Based Sorbents and Oxidizing Agents

    SciTech Connect (OSTI)

    Thomas K. Gale

    2005-07-01

    This Final Report contains the test descriptions, results, analysis, correlations, theoretical descriptions, and model derivations produced from many different investigations performed on a project funded by the U.S. Department of Energy, to investigate calcium-based sorbents and injection of oxidizing agents for the removal of mercury. Among the technologies were (a) calcium-based sorbents in general, (b) oxidant-additive sorbents developed originally at the EPA, and (c) optimized calcium/carbon synergism for mercury-removal enhancement. In addition, (d) sodium-tetrasulfide injection was found to effectively capture both forms of mercury across baghouses and ESPs, and has since been demonstrated at a slipstream treating PRB coal. It has been shown that sodium-tetrasulfide had little impact on the foam index of PRB flyash, which may indicate that sodium-tetrasulfide injection could be used at power plants without affecting flyash sales. Another technology, (e) coal blending, was shown to be an effective means of increasing mercury removal, by optimizing the concentration of calcium and carbon in the flyash. In addition to the investigation and validation of multiple mercury-control technologies (a through e above), important fundamental mechanism governing mercury kinetics in flue gas were elucidated. For example, it was shown, for the range of chlorine and unburned-carbon (UBC) concentrations in coal-fired utilities, that chlorine has much less effect on mercury oxidation and removal than UBC in the flyash. Unburned carbon enhances mercury oxidation in the flue gas by reacting with HCl to form chlorinated-carbon sites, which then react with elemental mercury to form mercuric chloride, which subsequently desorbs back into the flue gas. Calcium was found to enhance mercury removal by stabilizing the oxidized mercury formed on carbon surfaces. Finally, a model was developed to describe these mercury adsorption, desorption, oxidation, and removal mechanisms, including

  3. Method for distributed agent-based non-expert simulation of manufacturing process behavior

    DOE Patents [OSTI]

    Ivezic, Nenad; Potok, Thomas E.

    2004-11-30

    A method for distributed agent based non-expert simulation of manufacturing process behavior on a single-processor computer comprises the steps of: object modeling a manufacturing technique having a plurality of processes; associating a distributed agent with each the process; and, programming each the agent to respond to discrete events corresponding to the manufacturing technique, wherein each discrete event triggers a programmed response. The method can further comprise the step of transmitting the discrete events to each agent in a message loop. In addition, the programming step comprises the step of conditioning each agent to respond to a discrete event selected from the group consisting of a clock tick message, a resources received message, and a request for output production message.

  4. Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy

    DOE Patents [OSTI]

    Katti, Kattesh V.; Prabhu, Kandikere R.; Gali, Hariprasad; Pillarsetty, Nagavara Kishore; Volkert, Wynn A.

    2003-10-21

    There is provided a method of labeling a biomolecule with a transition metal or radiometal in a site specific manner to produce a diagnostic or therapeutic pharmaceutical compound by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radio metal or a transition metal, and covalently linking the resulting metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. Also provided is a method of synthesizing the --PR.sub.2 containing biomolecules by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radiometal or a transition metal, and covalently linking the resulting radio metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. There is provided a therapeutic or diagnostic agent comprising a --PR.sub.2 containing biomolecule.

  5. Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents

    DOE Patents [OSTI]

    Wachter, Eric A.; Fisher, Walter G.; Dees, H. Craig

    2008-03-18

    A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method comprises the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention also provides a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

  6. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

    DOE Patents [OSTI]

    Wachter, E.A.; Fisher, W.G.; Dees, H.C.

    1998-11-10

    A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent. 13 figs.

  7. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

    DOE Patents [OSTI]

    Wachter, Eric A.; Fisher, Walter G.; Dees, H. Craig

    1998-01-01

    A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

  8. Methods, microfluidic devices, and systems for detection of an active enzymatic agent

    DOE Patents [OSTI]

    Sommer, Gregory J; Hatch, Anson V; Singh, Anup K; Wang, Ying-Chih

    2014-10-28

    Embodiments of the present invention provide methods, microfluidic devices, and systems for the detection of an active target agent in a fluid sample. A substrate molecule is used that contains a sequence which may cleave in the presence of an active target agent. A SNAP25 sequence is described, for example, that may be cleaved in the presence of Botulinum Neurotoxin. The substrate molecule includes a reporter moiety. The substrate molecule is exposed to the sample, and resulting reaction products separated using electrophoretic separation. The elution time of the reporter moiety may be utilized to identify the presence or absence of the active target agent.

  9. Multirate delivery of multiple therapeutic agents from metal-organic frameworks

    SciTech Connect (OSTI)

    McKinlay, Alistair C.; Allan, Phoebe K.; Renouf, Catherine L.; Duncan, Morven J.; Wheatley, Paul S.; Warrender, Stewart J.; Dawson, Daniel; Ashbrook, Sharon E.; Gil, Barbara; Marszalek, Bartosz; Dren, Tina; Williams, Jennifer J.; Charrier, Cedric; Mercer, Derry K.; Teat, Simon J.; Morris, Russell E.

    2014-12-01

    The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agentsa biologically active gas, an antibiotic drug molecule, and an active metal ionsimultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

  10. Agents for replacement of NAD+/NADH system in enzymatic reactions

    DOE Patents [OSTI]

    Fish, Richard H.; Kerr, John B.; Lo, Christine H.

    2004-04-06

    Novel agents acting as co-factors for replacement of NAD(P).sup.+ /NAD(P)H co-enzyme systems in enzymatic oxido-reductive reactions. Agents mimicking the action of NAD(P).sup.+ /NAD(P)H system in enzymatic oxidation/reduction of substrates into reduced or oxidized products. A method for selection and preparation of the mimicking agents for replacement of NAD(P).sup.+ /NAD(P)H system and a device comprising co-factors for replacement of NAD(P).sup.+ /NAD(P)H system.

  11. Suppression of alkylating agent induced cell transformation and gastric ulceration by low-dose alkylating agent pretreatment

    SciTech Connect (OSTI)

    Onodera, Akira; Department of Pharmaceutical Sciences, Kobegakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe 650-8586 ; Kawai, Yuichi; Kashimura, Asako; Ogita, Fumiya; Tsutsumi, Yasuo; Itoh, Norio

    2013-06-14

    Highlights: Low-dose MNNG pretreatment suppresses high-dose MNNG induced in vitro transformation. Gastric ulcers induced by high-dose MNNG decreased after low-dose MNNG pretreatment. Efficacy of low-dose MNNG related to resistance of mutation and oxidative stress. -- Abstract: Exposure to mild stress by chemicals and radiation causes DNA damage and leads to acquired stress resistance. Although the linear no-threshold (LNT) model of safety assessment assumes risk from any dose, evidence from radiological research demonstrates a conflicting hormetic phenomenon known as the hormesis effect. However, the mechanisms underlying radiation hormesis have not yet been clarified, and little is known about the effects of low doses of chemical carcinogens. We analyzed the efficacy of pretreatment with low doses of the alkylating agent N-methyl-N?-nitro-N-nitrosoguanidine (MNNG) on the subsequent induction of cell transformation and gastric ulceration by high-dose MNNG. We used an in vitro Balb/3T3 A31-1-1 cell transformation test and monitored the formation of gastric ulcers in 5-week-old male ICR mice that were administered MNNG in drinking water. The treatment concentrations of MNNG were determined by the cell survival rate and past reports. For low-dose in vitro and in vivo experiments, MNNG was used at 0.028 ?M, and 2.8 ?g/mL, respectively. The frequency of cell transformation induced by 10 ?m MNNG was decreased by low-dose MNNG pretreatment to levels similar to that of spontaneous transformation. In addition, reactive oxygen species (ROS) and mutation frequencies induced by 10 ?m MNNG were decreased by low-dose MNNG pretreatment. Importantly, low-dose MNNG pretreatment had no effect on cell proliferation. In vivo studies showed that the number of gastric ulcers induced by 1 mg/mL MNNG decreased after low-dose MNNG pretreatment. These data indicate that low-dose pretreatment with carcinogens may play a beneficial role in the prevention of chemical toxicity under

  12. Metagenomics for Etiologic Agent Discovery (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema (OSTI)

    Ross, Matthew [Baylor College of Medicine

    2013-02-11

    Matthew Ross on "Metagenomics for etiological agent discovery" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  13. The Safe Handling, Transfer, and Receipt of Biological Etiologic Agents at Department of Energy Facilities

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-10-17

    To establish requirements and assign responsibilities for the Department of Energy (DOE), including the National Nuclear Security Administration (NNSA), biological etiologic agent program. DOE N 450.14 extends this directive until 06/30/2006.

  14. Measuring indigenous photosynthetic organisms to detect chemical warefare agents in water

    DOE Patents [OSTI]

    Greenbaum, Elias; Sanders, Charlene A.

    2005-11-15

    A method of testing water to detect the presence of a chemical or biological warfare agent is disclosed. The method is carried out by establishing control data by providing control water containing indigenous organisms but substantially free of a chemical and a biological warfare agent. Then measuring photosynthetic activity of the control water with a fluorometer to obtain control data to compare with test data to detect the presence of the chemical or agent. The test data is gathered by providing test water comprising the same indigenous organisms as contained in the control water. Further, the test water is suspected of containing the chemical or agent to be tested for. Photosynthetic activity is also measured by fluorescence induction in the test water using a fluorometer.

  15. Conduct and Approval of Select Agent and Toxin Work at Department of Energy Sites

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-11-07

    The policy establishes expectations for the operating DOE research laboratories utilizing select agents and toxins (as regulated by the United States Department of Health and Human Services). Supersedes DOE P 434.1.

  16. Method for improved selectivity in photo-activation of molecular agents

    DOE Patents [OSTI]

    Fisher, Walter G.; Wachter, Eric A.; Dees, H. Craig

    2000-01-01

    An apparatus for the treatment of a particular volume of plant or animal tissue by treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue.

  17. Plasma flame for mass purification of contaminated air with chemical and biological warfare agents

    SciTech Connect (OSTI)

    Uhm, Han S.; Shin, Dong H.; Hong, Yong C.

    2006-09-18

    An elimination of airborne simulated chemical and biological warfare agents was carried out by making use of a plasma flame made of atmospheric plasma and a fuel-burning flame, which can purify the interior air of a large volume in isolated spaces such as buildings, public transportation systems, and military vehicles. The plasma flame generator consists of a microwave plasma torch connected in series to a fuel injector and a reaction chamber. For example, a reaction chamber, with the dimensions of a 22 cm diameter and 30 cm length, purifies an airflow rate of 5000 lpm contaminated with toluene (the simulated chemical agent) and soot from a diesel engine (the simulated aerosol for biological agents). Large volumes of purification by the plasma flame will free mankind from the threat of airborne warfare agents. The plasma flame may also effectively purify air that is contaminated with volatile organic compounds, in addition to eliminating soot from diesel engines as an environmental application.

  18. Chemical agents for conversion of chrysotile asbestos into non-hazardous materials

    DOE Patents [OSTI]

    Sugama, Toshifumi; Petrakis, Leon

    1998-06-09

    A composition and methods for converting a chrysotile asbestos-containing material to a non-regulated environmentally benign solid which comprises a fluoro acid decomposing agent capable of dissociating the chrysotile asbestos to non-regulated components, wherein non-regulated components are non-reactive with the environment, and a binding agent which binds the non-regulated components to form an environmentally benign solid.

  19. Chemical agents for conversion of chrysotile asbestos into non-hazardous materials

    DOE Patents [OSTI]

    Sugama, Toshifumi; Petrakis, L.

    1998-06-09

    A composition and methods are disclosed for converting a chrysotile asbestos-containing material to a non-regulated environmentally benign solid which comprises a fluoro acid decomposing agent capable of dissociating the chrysotile asbestos to non-regulated components, wherein non-regulated components are non-reactive with the environment, and a binding agent which binds the non-regulated components to form an environmentally benign solid. 2 figs.

  20. Valorization of titanium metal wastes as tanning agent used in leather industry

    SciTech Connect (OSTI)

    Crudu, Marian; Deselnicu, Viorica; Deselnicu, Dana Corina; Albu, Luminita

    2014-10-15

    Highlights: • Valorization of titanium wastes which cannot be recycled in metallurgical industry. • Transferring Ti waste into raw materials for obtaining Ti based tanning agent. • Characterization of new Ti based tanning agents and leather tanned with them. • Characterization of sewage waste water and sludge resulted from leather manufacture. • Analysis of the impact of main metal component of Ti waste. - Abstract: The development of new tanning agents and new technologies in the leather sector is required to cope with the increasingly higher environmental pressure on the current tanning materials and processes such as tanning with chromium salts. In this paper, the use of titanium wastes (cuttings) resulting from the process of obtaining highly pure titanium (ingots), for the synthesis of new tanning agent and tanning bovine hides with new tanning agent, as alternative to tanning with chromium salts are investigated. For this purpose, Ti waste and Ti-based tanning agent were characterized for metal content by inductively coupled plasma mass spectrometry (ICP-MS) and chemical analysis; the tanned leather (wet white leather) was characterized by Scanning Electron Microscope/Energy Dispersive Using X-ray (Analysis). SEM/EDX analysis for metal content; Differential scanning calorimetric (DSC), Micro-Hot-Table and standard shrinkage temperature showing a hydrothermal stability (ranged from 75.3 to 77 °C) and chemical analysis showing the leather is tanned and can be processed through the subsequent mechanical operations (splitting, shaving). On the other hand, an analysis of major minor trace substances from Ti-end waste (especially vanadium content) in new tanning agent and wet white leather (not detected) and residue stream was performed and showed that leachability of vanadium is acceptable. The results obtained show that new tanning agent obtained from Ti end waste can be used for tanning bovine hides, as eco-friendly alternative for chrome tanning.

  1. Heavy Alcohols as a Fuel Blending Agent for Compression Ignition Engine

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Applications | Department of Energy Alcohols as a Fuel Blending Agent for Compression Ignition Engine Applications Heavy Alcohols as a Fuel Blending Agent for Compression Ignition Engine Applications Blends of Phytol and diesel (by volume) were compared against baseline diesel experiments and simulations p-21_ramirez.pdf (351.23 KB) More Documents & Publications HD Applications of Significantly Downsized SI Engines Using Alcohol DI for Knock Avoidance Characterization of Dual-Fuel

  2. Method for preparing radionuclide-labeled chelating agent-ligand complexes

    DOE Patents [OSTI]

    Meares, Claude F.; Li, Min; DeNardo, Sally J.

    1999-01-01

    Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as .sup.90 Y or .sup.111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.

  3. Raidiation-Induced Fragmentation of Diamide Extraction Agents in Ionic Liquid Diluents

    SciTech Connect (OSTI)

    Bell, Jason R; Dai, Sheng; Shkrob, Ilya A.; Marin, Timothy W.; Luo, Huimin; Hatcher, Jasmine; Rimmer, R. Dale; Wishart, James F.

    2012-01-01

    N,N,N',N'-Tetraalkyldiglycolamides are extracting agents that are used for liquid-liquid extraction of trivalent metal ions in wet processing of spent nuclear fuel. This application places such agents in contact with the decaying radionuclides, causing radiolysis of the agent in the organic diluent. Recent research seeks to replace common molecular diluents (such as n-dodecane) with hydrophobic room-temperature ionic liquids (ILs), which have superior solvation properties. In alkane diluents, rapid radiolytic deterioration of diglycolamide agents can be inhibited by addition of an aromatic cosolvent that scavenges highly reactive alkane radical cations before these oxidize the extracting agent. Do aromatic ILs exhibit a similar radioprotective effect? To answer this question, we used electron paramagnetic resonance spectroscopy to study the fragmentation pathways in radiolysis of neat diglycolamides, their model compounds, and their solutions in the ILs. Our study indicates that aromatic ILs do not protect these types of solutes from extensive radiolytic damage. Previous research indicated a similar lack of protection for crown ethers, whereas the ILs readily protected di- and trialkyl phosphates (another large class of metal-extracting agents). Our analysis of these unanticipated failures suggests that new types of organic anions are required in order to formulate ILs capable of radioprotection for these classes of solutes. This study is a cautionary tale of the fallacy of analogical thinking when applied to an entirely new and insufficiently understood class of chemical materials.

  4. Mass spectrometry in identification of ecotoxicants including chemical and biological warfare agents

    SciTech Connect (OSTI)

    Lebedev, Albert T. . E-mail: lebedev@org.chem.msu.ru

    2005-09-01

    Mass spectrometry is a unique tool to detect and identify trace levels of organic and bioorganic compounds as well as microorganisms in the environment. The range of potential chemical warfare (CW) and biological warfare (BW) agents is very broad. An important advantage of mass spectrometry over other techniques involves potential for full spectrum detection of chemical and biological agents including mid-spectrum materials (i.e. bioactive peptides, toxins, etc.) for which biological approaches are inadequate. Being very fast (seconds and minutes), extremely sensitive (zeptomoles 10{sup -21}), and informative (detailed qualitative and quantitative composition of mixtures containing hundreds of chemicals), mass spectrometry is a principal analytical tool at the sites of destruction of CW. Due to its unique features, mass spectrometry is applied not only for the detection of CW agents, but for the analysis of products of metabolism and degradation of these agents in organisms or environment as well. The present paper deals with some examples of successful application of mass spectrometry for the analyses of ecotoxicants, chemical warfare agents, explosives, and microorganisms including biology warfare agents.

  5. Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents

    SciTech Connect (OSTI)

    Yadav, N.; Kumar, S.; Marlowe, T.; Chaudhary, A. K.; Kumar, R.; Wang, J.; O'Malley, J.; Boland, P. M.; Jayanthi, S.; Kumar, T. K. S.; Yadava, N.; Chandra, D.

    2015-11-05

    Cancer cells tend to develop resistance to various types of anticancer agents, whether they adopt similar or distinct mechanisms to evade cell death in response to a broad spectrum of cancer therapeutics is not fully defined. Current study concludes that DNA-damaging agents (etoposide and doxorubicin), ER stressor (thapsigargin), and histone deacetylase inhibitor (apicidin) target oxidative phosphorylation (OXPHOS) for apoptosis induction, whereas other anticancer agents including staurosporine, taxol, and sorafenib induce apoptosis in an OXPHOS-independent manner. DNA-damaging agents promoted mitochondrial biogenesis accompanied by increased accumulation of cellular and mitochondrial ROS, mitochondrial protein-folding machinery, and mitochondrial unfolded protein response. Induction of mitochondrial biogenesis occurred in a caspase activation-independent mechanism but was reduced by autophagy inhibition and p53-deficiency. Abrogation of complex-I blocked DNA-damage-induced caspase activation and apoptosis, whereas inhibition of complex-II or a combined deficiency of OXPHOS complexes I, III, IV, and V due to impaired mitochondrial protein synthesis did not modulate caspase activity. Mechanistic analysis revealed that inhibition of caspase activation in response to anticancer agents associates with decreased release of mitochondrial cytochrome c in complex-I-deficient cells compared with wild type (WT) cells. Gross OXPHOS deficiencies promoted increased release of apoptosis-inducing factor from mitochondria compared with WT or complex-I-deficient cells, suggesting that cells harboring defective OXPHOS trigger caspase-dependent as well as caspase-independent apoptosis in response to anticancer agents. Interestingly, DNA-damaging agent doxorubicin showed strong binding to mitochondria, which was disrupted by complex-I-deficiency but not by complex-II-deficiency. Thapsigargin-induced caspase activation was reduced upon abrogation of complex-I or gross OXPHOS deficiency

  6. Fate and control of blistering chemical warfare agents in Kuwait`s desalination industry

    SciTech Connect (OSTI)

    Khordagui, H.K.

    1997-01-01

    Kuwait, as most of the other states located along the Western shores of the Arabian Gulf, relies upon the Gulf as its main drinking water resource via desalination. In case of seawater contamination with blistering chemical warfare agents, traces of the agents and/or degradation products in the finished water might pose a serious health hazard. The objective of the present review is to study the potential contamination, transport, fate, effect and control of blistering chemical warfare agents (CWAs), in the Kuwaiti desalination industry. In general, all the environmental factors involved in the aquatic degradation of CWAs in Kuwait marine environment except for the high salinity in case of blistering agents such as sulphur mustard, and in favor of a fast degradation process. In case of massive releases of CWAs near the Kuwaiti shorelines, turbulence resulting from tidal cycles and high temperature will affect the dissolution process and extend the toxicity of the insoluble agent. Post- and pre-chlorination during the course of seawater desalination will catalyze and significantly accelerate the hydrolysis processes of the CWAs. The heat exerted on CWAs during the power generation-desalination processes is not expected to thermally decompose them. However, the steam heat will augment the agent`s rate of hydrolysis with subsequent acceleration in their rate of detoxification. Conventional pretreatment of feed seawater for reverse-osmosis desalination is theoretically capable of reducing the concentration of CWAs by coprecipitation and adsorption on flocs formed during coagulation. Prechlorination and prolonged detention in time in pretreatment units will simultaneously promote hydrolysis reactions. 50 refs.

  7. Anaerobic treatment of aircraft de-icing agent using the SNC-LAVALIN Multiplate Reactor

    SciTech Connect (OSTI)

    Mulligan, C.; Chebib, J.; Safi, B.

    1997-12-31

    A system for the anaerobic treatment of aircraft de-icing agent has been developed by SNC Research Corp., a subsidiary of the SNC-LAVALIN Group (Montreal, Canada). The de-icing agent used in the evaluation contains 54% ethylene glycol, 46% water and trace additives such as surfactants and colorants. The process is comprised of a buffer tank and the SNC-LAVALIN Multiplate Reactor and is as follows. The effluent containing the aircraft de-icing agent with ethylene glycol as the major component enters the buffer tank where the temperature and pH adjustment and the addition of nutrients takes place. The water is then sent to the SNC-LAVALIN Multiplate Reactor. Here, the de-icing agent is converted to biogas which contains 80% methane and the liquid effluent which is essentially ethylene glycol free is discharged. The biogas can be either burned in a flare or used for heating purposes. The following results are typical for the aircraft de-icing agent: Greater than 90% total COD and 99% ethylene glycol removal at an organic load of 15 kg COD/m{sup 3}-day. The de-icing agent can be collected and subsequently treated on-site using the SNC-LAVALIN system. The advantages of the SNC-LAVALIN system are low capital and operating costs, possibility of treating a wide range of de-icing agent concentrations and other liquid effluents unlike evaporation processes, potential recuperation of the biogas and a gentle technology for the environment without generation of VOCs.

  8. Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yadav, N.; Kumar, S.; Marlowe, T.; Chaudhary, A. K.; Kumar, R.; Wang, J.; O'Malley, J.; Boland, P. M.; Jayanthi, S.; Kumar, T. K. S.; et al

    2015-11-05

    Cancer cells tend to develop resistance to various types of anticancer agents, whether they adopt similar or distinct mechanisms to evade cell death in response to a broad spectrum of cancer therapeutics is not fully defined. Current study concludes that DNA-damaging agents (etoposide and doxorubicin), ER stressor (thapsigargin), and histone deacetylase inhibitor (apicidin) target oxidative phosphorylation (OXPHOS) for apoptosis induction, whereas other anticancer agents including staurosporine, taxol, and sorafenib induce apoptosis in an OXPHOS-independent manner. DNA-damaging agents promoted mitochondrial biogenesis accompanied by increased accumulation of cellular and mitochondrial ROS, mitochondrial protein-folding machinery, and mitochondrial unfolded protein response. Induction of mitochondrialmore » biogenesis occurred in a caspase activation-independent mechanism but was reduced by autophagy inhibition and p53-deficiency. Abrogation of complex-I blocked DNA-damage-induced caspase activation and apoptosis, whereas inhibition of complex-II or a combined deficiency of OXPHOS complexes I, III, IV, and V due to impaired mitochondrial protein synthesis did not modulate caspase activity. Mechanistic analysis revealed that inhibition of caspase activation in response to anticancer agents associates with decreased release of mitochondrial cytochrome c in complex-I-deficient cells compared with wild type (WT) cells. Gross OXPHOS deficiencies promoted increased release of apoptosis-inducing factor from mitochondria compared with WT or complex-I-deficient cells, suggesting that cells harboring defective OXPHOS trigger caspase-dependent as well as caspase-independent apoptosis in response to anticancer agents. Interestingly, DNA-damaging agent doxorubicin showed strong binding to mitochondria, which was disrupted by complex-I-deficiency but not by complex-II-deficiency. Thapsigargin-induced caspase activation was reduced upon abrogation of complex-I or gross OXPHOS

  9. Reevaluation of 1999 Health-Based Environmental Screening Levels (HBESLs) for Chemical Warfare Agents

    SciTech Connect (OSTI)

    Watson, Annetta Paule; Dolislager, Fredrick G

    2007-05-01

    This report evaluates whether new information and updated scientific models require that changes be made to previously published health-based environmental soil screening levels (HBESLs) and associated environmental fate/breakdown information for chemical warfare agents (USACHPPM 1999). Specifically, the present evaluation describes and compares changes that have been made since 1999 to U.S. Environmental Protection Agency (EPA) risk assessment models, EPA exposure assumptions, as well as to specific chemical warfare agent parameters (e.g., toxicity values). Comparison was made between screening value estimates recalculated with current assumptions and earlier health-based environmental screening levels presented in 1999. The chemical warfare agents evaluated include the G-series and VX nerve agents and the vesicants sulfur mustard (agent HD) and Lewisite (agent L). In addition, key degradation products of these agents were also evaluated. Study findings indicate that the combined effect of updates and/or changes to EPA risk models, EPA default exposure parameters, and certain chemical warfare agent toxicity criteria does not result in significant alteration to the USACHPPM (1999) health-based environmental screening level estimates for the G-series and VX nerve agents or the vesicant agents HD and L. Given that EPA's final position on separate Tier 1 screening levels for indoor and outdoor worker screening assessments has not yet been released as of May 2007, the study authors find that the 1999 screening level estimates (see Table ES.1) are still appropriate and protective for screening residential as well as nonresidential sites. As such, risk management decisions made on the basis of USACHPPM (1999) recommendations do not require reconsideration. While the 1999 HBESL values are appropriate for continued use as general screening criteria, the updated '2007' estimates (presented below) that follow the new EPA protocols currently under development are also

  10. Method for improved selectivity in photo-activation of molecular agents

    DOE Patents [OSTI]

    Fisher, Walter G.; Wachter, Eric A.; Dees, H. Craig

    1999-01-01

    A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

  11. Method for improved selectivity in photo-activation of molecular agents

    DOE Patents [OSTI]

    Fisher, W.G.; Wachter, E.A.; Dees, H.C.

    1998-11-03

    A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material. 23 figs.

  12. Method for improved selectivity in photo-activation of molecular agents

    DOE Patents [OSTI]

    Fisher, Walter G.; Wachter, Eric A.; Dees, H. Craig

    1998-01-01

    A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

  13. Novel Cleanup Agents Designed Exclusively for Oil Field Membrane Filtration Systems Low Cost Field Demonstrations of Cleanup Agents in Controlled Experimental Environments

    SciTech Connect (OSTI)

    David Burnett; Harold Vance

    2007-08-31

    The goal of our project is to develop innovative processes and novel cleaning agents for water treatment facilities designed to remove fouling materials and restore micro-filter and reverse osmosis (RO) membrane performance. This project is part of Texas A&M University's comprehensive study of the treatment and reuse of oilfield brine for beneficial purposes. Before waste water can be used for any beneficial purpose, it must be processed to remove contaminants, including oily wastes such as residual petroleum hydrocarbons. An effective way of removing petroleum from brines is the use of membrane filters to separate oily waste from the brine. Texas A&M and its partners have developed highly efficient membrane treatment and RO desalination for waste water including oil field produced water. We have also developed novel and new cleaning agents for membrane filters utilizing environmentally friendly materials so that the water from the treatment process will meet U.S. EPA drinking water standards. Prototype micellar cleaning agents perform better and use less clean water than alternate systems. While not yet optimized, the new system restores essentially complete membrane flux and separation efficiency after cleaning. Significantly the amount of desalinated water that is required to clean the membranes is reduced by more than 75%.

  14. System configured for applying a modifying agent to a non-equidimensional substrate

    DOE Patents [OSTI]

    Janikowski, Stuart K.; Toth, William J.; Ginosar, Daniel M.; Allen, Charles A.; Argyle, Mark D.; Fox, Robert V.; Propp, W. Alan; Miller, David L.

    2003-09-23

    The present invention is related to systems and methods for modifying various non-equidimensional substrates with modifying agents. The system comprises a processing chamber configured for passing the non-equidimensional substrate therethrough, wherein the processing chamber is further configured to accept a treatment mixture into the chamber during movement of the non-equidimensional substrate through the processing chamber. The treatment mixture can comprise of the modifying agent in a carrier medium, wherein the carrier medium is selected from the group consisting of a supercritical fluid, a near-critical fluid, a superheated fluid, a superheated liquid, and a liquefied gas. Thus, the modifying agent can be applied to the non-equidimensional substrate upon contact between the treatment mixture and the non-equidimensional substrate.

  15. Architectural considerations for agent-based national scale policy models : LDRD final report.

    SciTech Connect (OSTI)

    Backus, George A.; Strip, David R.

    2007-09-01

    The need to anticipate the consequences of policy decisions becomes ever more important as the magnitude of the potential consequences grows. The multiplicity of connections between the components of society and the economy makes intuitive assessments extremely unreliable. Agent-based modeling has the potential to be a powerful tool in modeling policy impacts. The direct mapping between agents and elements of society and the economy simplify the mapping of real world functions into the world of computation assessment. Our modeling initiative is motivated by the desire to facilitate informed public debate on alternative policies for how we, as a nation, provide healthcare to our population. We explore the implications of this motivation on the design and implementation of a model. We discuss the choice of an agent-based modeling approach and contrast it to micro-simulation and systems dynamics approaches.

  16. Market power analysis in the EEX electricity market : an agent-based simulation approach.

    SciTech Connect (OSTI)

    Wang, J.; Botterud, A.; Conzelmann, G.; Koritarov, V.; Decision and Information Sciences

    2008-01-01

    In this paper, an agent-based modeling and simulation (ABMS) approach is used to model the German wholesale electricity market. The spot market prices in the European Energy Exchange (EEX) are studied as the wholesale market prices. Each participant in the market is modeled as an individual rationality-bounded agent whose objective is to maximize its own profit. By simulating the market clearing process, the interaction among agents is captured. The market clearing price formed by agentspsila production cost bidding is regarded as the reference marginal cost. The gap between the marginal cost and the real market price is measured as an indicator of possible market power exertion. Various bidding strategies such as physical withholding and economic withholding can be simulated to represent strategic bidding behaviors of the market participants. The preliminary simulation results show that some generation companies (GenCos) are in the position of exerting market power by strategic bidding.

  17. System configured for applying a modifying agent to a non-equidimensional substrate

    DOE Patents [OSTI]

    Janikowski; Stuart K. , Argyle; Mark D. , Fox; Robert V. , Propp; W. Alan , Toth; William J. , Ginosar; Daniel M. , Allen; Charles A. , Miller; David L.

    2007-07-10

    The present invention is related to systems and methods for modifying various non-equidimensional substrates with modifying agents. The system comprises a processing chamber configured for passing the non-equidimensional substrate therethrough, wherein the processing chamber is further configured to accept a treatment mixture into the chamber during movement of the non-equidimensional substrate through the processing chamber. The treatment mixture can comprise of the modifying agent in a carrier medium, wherein the carrier medium is selected from the group consisting of a supercritical fluid, a near-critical fluid, a superheated fluid, a superheated liquid, and a liquefied gas. Thus, the modifying agent can be applied to the non-equidimensional substrate upon contact between the treatment mixture and the non-equidimensional substrate.

  18. Methods and kits for predicting a response to an erythropoietic agent

    DOE Patents [OSTI]

    Merchant, Michael L.; Klein, Jon B.; Brier, Michael E.; Gaweda, Adam E.

    2015-06-16

    Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17.

  19. A mobile-agent based wireless sensing network for structural monitoring applications

    SciTech Connect (OSTI)

    Taylor, Stuart G; Farinholt, Kevin M; Figueiredo, Eloi; Park, Gyuhae; Farrar, Charles R; Flynn, Eric B; Mascarenas, David L; Todd, Michael D

    2008-01-01

    A new wireless sensing network paradigm is presented for structural monitoring applications. In this approach, both power and data interrogation commands are conveyed via a mobile agent that is sent to sensor nodes to perform intended interrogations, which can alleviate several limitations of the traditional sensing networks. Furthermore, the mobile agent provides computational power to make near real-time assessments on the structural conditions. This paper will discuss such prototype systems, which are used to interrogate impedance-based sensors for structural health monitoring applications. Our wireless sensor node is specifically designed to accept various energy sources, including wireless energy transmission, and to be wirelessly triggered on an as-needed basis by the mobile agent or other sensor nodes. The capabilities of this proposed sensing network paradigm are demonstrated in the laboratory and the field.

  20. Genetic Algorithms for Agent-Based Infrastructure Interdependency Modeling and Analysis

    SciTech Connect (OSTI)

    May Permann

    2007-03-01

    Today’s society relies greatly upon an array of complex national and international infrastructure networks such as transportation, electric power, telecommunication, and financial networks. This paper describes initial research combining agent-based infrastructure modeling software and genetic algorithms (GAs) to help optimize infrastructure protection and restoration decisions. This research proposes to apply GAs to the problem of infrastructure modeling and analysis in order to determine the optimum assets to restore or protect from attack or other disaster. This research is just commencing and therefore the focus of this paper is the integration of a GA optimization method with a simulation through the simulation’s agents.

  1. Multirate delivery of multiple therapeutic agents from metal-organic frameworks

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    McKinlay, Alistair C.; Allan, Phoebe K.; Renouf, Catherine L.; Duncan, Morven J.; Wheatley, Paul S.; Warrender, Stewart J.; Dawson, Daniel; Ashbrook, Sharon E.; Gil, Barbara; Marszalek, Bartosz; et al

    2014-12-01

    The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

  2. Spatial process and data models : toward integration of agent-based models and GIS.

    SciTech Connect (OSTI)

    Brown, D. G.; North, M. J.; Robinson, D. T.; Riolo, R.; Rand, W.; Decision and Information Sciences; Univ. of Michigan

    2007-10-01

    The use of object-orientation for both spatial data and spatial process models facilitates their integration, which can allow exploration and explanation of spatial-temporal phenomena. In order to better understand how tight coupling might proceed and to evaluate the possible functional and efficiency gains from such a tight coupling, we identify four key relationships affecting how geographic data (fields and objects) and agent-based process models can interact: identity, causal, temporal and topological. We discuss approaches to implementing tight integration, focusing on a middleware approach that links existing GIS and ABM development platforms, and illustrate the need and approaches with example agent-based models.

  3. Method and apparatus for the gas phase decontamination of chemical and biological agents

    DOE Patents [OSTI]

    O'Neill, Hugh J.; Brubaker, Kenneth L.

    2003-10-07

    An apparatus and method for decontaminating chemical and biological agents using the reactive properties of both the single atomic oxygen and the hydroxyl radical for the decontamination of chemical and biological agents. The apparatus is self contained and portable and allows for the application of gas reactants directly at the required decontamination point. The system provides for the use of ultraviolet light of a specific spectral range to photolytically break down ozone into molecular oxygen and hydroxyl radicals where some of the molecular oxygen is in the first excited state. The excited molecular oxygen will combine with water vapor to produce two hydroxyl radicals.

  4. General guidelines for medically screening mixed population groups potentially exposed to nerve or vesicant agents

    SciTech Connect (OSTI)

    Watson, A.P.; Munro, N.B.; Sidell, F.R.; Leffingwell, S.S.

    1992-01-01

    A number of state and local planners have requested guidance on screening protocols and have expressed interest in sampling body fluids from exposed or potentially exposed individuals as a means of estimating agent dose. These guidelines have been developed to provide a clear statement that could be used by state and local emergency response personnel in the event of a nerve or vesicant agent incident resulting in off-post contamination; maximum protection from harm is the goal. The assumption is that any population group so exposed would be heterogeneous for age, gender, reproductive status, and state of health.

  5. Tissue-based water quality biosensors for detecting chemical warfare agents

    DOE Patents [OSTI]

    Greenbaum, Elias; Sanders, Charlene A.

    2003-05-27

    A water quality sensor for detecting the presence of at least one chemical or biological warfare agent includes: a cell; apparatus for introducing water into the cell and discharging water from the cell adapted for analyzing photosynthetic activity of naturally occurring, free-living, indigenous photosynthetic organisms in water; a fluorometer for measuring photosynthetic activity of naturally occurring, free-living, indigenous photosynthetic organisms drawn into the cell; and an electronics package that analyzes raw data from the fluorometer and emits a signal indicating the presence of at least one chemical or biological warfare agent in the water.

  6. Operating Experience Level 3, NRC Notice: Antifreeze Agents in Fire Water Sprinkler Systems

    Broader source: Energy.gov [DOE]

    This Operating Experience Level 3 (OE-3) document provides information about safety concerns identified by the Nuclear Regulatory Commission (NRC) that could potentially apply to work performed at Department of Energy (DOE) facilities. These concerns were identified in NRC Information Notice (IN) 2015-02, Antifreeze Agents in Fire Water Sprinkler Systems.

  7. EA-2026: Biomedical Research at Existing Biosafety Level 3 Laboratories with Registered Select Agent Programs

    Broader source: Energy.gov [DOE]

    This EA will evaluate the environmental consequences resulting from DOE’s proposed action for Pacific Northwest National Laboratory-affiliated staff to access and use existing, operating biosafety level 3 (BSL-3) facilities with select agent registration to conduct biomedical research.

  8. Method for forming an extraction agent for the separation of actinides from lanthanides

    DOE Patents [OSTI]

    Klaehn, John R.; Harrup, Mason K.; Law, Jack D.; Peterman, Dean R.

    2010-04-27

    An extraction agent for the separation of trivalent actinides from lanthanides in an acidic media and a method for forming same are described, and wherein the methodology produces a stable regiospecific and/or stereospecific dithiophosphinic acid that can operate in an acidic media having a pH of less than about 7.

  9. Disposal of chemical agents and munitions stored at Pine Bluff Arsenal, Pine Bluff, Arkansas

    SciTech Connect (OSTI)

    Ensminger, J.T.; Hillsman, E.L.; Johnson, R.D.; Morrisey, J.A.; Staub, W.P.; Boston, C.R.; Hunsaker, D.B.; Leibsch, E.; Rickert, L.W.; Tolbert, V.R.; Zimmerman, G.P.

    1991-09-01

    The Pine Bluff Arsenal (PBA) near Pine Bluff, Arkansas, is one of eight continental United States (CONUS) Army installations where lethal unitary chemical agents and munitions are stored and where destruction of agents and munitions is proposed under the Chemical Stockpile Disposal Program (CSDP). The chemical agent inventory at PBA consists of approximately 12%, by weight, of the total US stockpile. The destruction of the stockpile is necessary to eliminate the risk to the public from continued storage and to dispose of obsolete and leaking munitions. In 1988 the US Army issued a Final Programmatic Environmental Impact Statement (FPEIS) for the CSDP that identified on-site disposal of agents and munitions as the environmentally preferred alternative (i.e., the alternative with the least potential to cause significant adverse impacts). The purpose of this report is to examine the proposed implementation of on-site disposal at PBA in light of more recent and more detailed data than those on which the FPEIS is based. New population data were used to compute fatalities using the same computation methods and values for all other parameters as in the FPEIS. Results indicate that all alternatives are indistinguishable when the potential health impacts to the PBA community are considered. However, risks from on-site disposal are in all cases equal to or less than risks from other alternatives. Furthermore, no unique resources with the potential to prevent or delay implementation of on-site disposal at PBA have been identified.

  10. Conduct and Approval of Select Agent and Toxin Work at Department of Energy Sites

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-06-05

    The purpose of this policy is to establish the Departments expectations for the establishment and operation of DOE research laboratories utilizing select agents and toxins (as regulated by the United States Department of Health and Human Services), hereinafter called LABS, and to ensure future policy needs for the operation, coordination, and oversight of these LABS. . Canceled by DOE P 434.1A.

  11. ActivitySim: large-scale agent based activity generation for infrastructure simulation

    SciTech Connect (OSTI)

    Gali, Emmanuel; Eidenbenz, Stephan; Mniszewski, Sue; Cuellar, Leticia; Teuscher, Christof

    2008-01-01

    The United States' Department of Homeland Security aims to model, simulate, and analyze critical infrastructure and their interdependencies across multiple sectors such as electric power, telecommunications, water distribution, transportation, etc. We introduce ActivitySim, an activity simulator for a population of millions of individual agents each characterized by a set of demographic attributes that is based on US census data. ActivitySim generates daily schedules for each agent that consists of a sequence of activities, such as sleeping, shopping, working etc., each being scheduled at a geographic location, such as businesses or private residences that is appropriate for the activity type and for the personal situation of the agent. ActivitySim has been developed as part of a larger effort to understand the interdependencies among national infrastructure networks and their demand profiles that emerge from the different activities of individuals in baseline scenarios as well as emergency scenarios, such as hurricane evacuations. We present the scalable software engineering principles underlying ActivitySim, the socia-technical modeling paradigms that drive the activity generation, and proof-of-principle results for a scenario in the Twin Cities, MN area of 2.6 M agents.

  12. Survey: Destruction of chemical agent simulants in supercritical water oxidation. Master's thesis

    SciTech Connect (OSTI)

    Blank, M.R.

    1992-07-01

    The supercritical water oxidation (SCWO) process exhibits distinct advantages for destruction of toxic wastes. Examples of these wastes are two chemical agent simulants, dimethyl methylphosphonate (DMMP) and thiodiglycol (2,2'-thiodiethanol). DMMP is similar to the nerve agent GB Sarin in structure, and thiodiglycol is a hydrolysis product of the blister agent HD Sulfur Mustard. Both simulants are miscible in water and relatively non-toxic in comparison to the actual chemical agents. Using a Laboratory-scale, batch three temperatures were investigated: 425 deg C, 450 deg C, and 500 deg C with an initial concentration of one percent by volume, 11,450 mg/L for DMMP and 12,220 mg/L for thiodiglycol. Residence times investigated were: 1, 2, 3, 6, and 8 minutes. Reactor beat-up (H.U.) was determined to be one minute. Both pyrolysis and oxidation tests were conducted. Oxygen levels were uniformly set at 200% of stoichiometric requirements for the parent compounds.

  13. Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making

    DOE Patents [OSTI]

    Gakh, Andrei A; Vovk, Mykhaylo V; Mel& #x27; nychenko, Nina V; Sukach, Volodymyr A

    2012-10-23

    The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.

  14. Standardization of Chemical Protective Equipment for Protective Forces and Special Agents

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-03-29

    This Notice provides requirements for the standardization and procurement of chemical protective equipment for use by Department of Energy (DOE) protective forces and Special Agents of the Transportation Safeguards Division (TSD). DOE N 251.40, dated 5/3/01, extends this directive until 12/31/01. Does not cancel other directives.

  15. Zirconium doped nano-dispersed oxides of Fe, Al and Zn for destruction of warfare agents

    SciTech Connect (OSTI)

    Stengl, Vaclav; Houskova, Vendula; Bakardjieva, Snejana; Murafa, Nataliya; Marikova, Monika; Oplustil, Frantisek; Nemec, Tomas

    2010-11-15

    Zirconium doped nano dispersive oxides of Fe, Al and Zn were prepared by a homogeneous hydrolysis of the respective sulfate salts with urea in aqueous solutions. Synthesized metal oxide hydroxides were characterized using Brunauer-Emmett-Teller (BET) surface area and Barrett-Joiner-Halenda porosity (BJH), X-ray diffraction (XRD), infrared spectroscopy (IR), scanning electron microscopy (SEM) and energy-dispersive X-ray microanalysis (EDX). These oxides were taken for an experimental evaluation of their reactivity with sulfur mustard (HD or bis(2-chloroethyl)sulfide), soman (GD or (3,3'-Dimethylbutan-2-yl)-methylphosphonofluoridate) and VX agent (S-[2-(diisopropylamino)ethyl]-O-ethyl-methylphosphonothionate). The presence of Zr{sup 4+} dopant can increase both the surface area and the surface hydroxylation of the resulting doped oxides, decreases their crystallites' sizes thereby it may contribute in enabling the substrate adsorption at the oxide surface thus it can accelerate the rate of degradation of warfare agents. Addition of Zr{sup 4+} converts the product of the reaction of ferric sulphate with urea from ferrihydrite to goethite. We found out that doped oxo-hydroxides Zr-FeO(OH) - being prepared by a homogeneous hydrolysis of ferric and zirconium oxo-sulfates mixture in aqueous solutions - exhibit a comparatively higher degradation activity towards chemical warfare agents (CWAs). Degradation of soman or VX agent on Zr-doped FeO(OH) containing ca. 8.3 wt.% of zirconium proceeded to completion within 30 min.

  16. Conduct and Approval of Select Agent and Toxin Work at Department of Energy Sites

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-04-18

    This directive provides the Department's expectations for the establishment and operation of DOE research laboratories utilizing select agents and toxins (as regulated by the United States Department of Health and Human Services), and to address future policy needs for the operation, coordination, and oversight of these laboratories.

  17. Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries

    SciTech Connect (OSTI)

    Tewari-Singh, Neera; Jain, Anil K.; Inturi, Swetha; Ammar, David A.; Agarwal, Chapla; Tyagi, Puneet; Kompella, Uday B.; Enzenauer, Robert W.; Petrash, J. Mark; Agarwal, Rajesh

    2012-10-01

    There are no effective and approved therapies against devastating ocular injuries caused by vesicating chemical agents sulfur mustard (SM) and nitrogen mustard (NM). Herein, studies were carried out in rabbit corneal cultures to establish relevant ocular injury biomarkers with NM for screening potential efficacious agents in laboratory settings. NM (100 nmol) exposure of the corneas for 2 h (cultured for 24 h), showed increases in epithelial thickness, ulceration, apoptotic cell death, epithelial detachment microbullae formation, and the levels of VEGF, cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9). Employing these biomarkers, efficacy studies were performed with agent treatments 2 h and every 4 h thereafter, for 24 h following NM exposure. Three agents were evaluated, including prescription drugs dexamethasone (0.1%; anti-inflammatory steroid) and doxycycline (100 nmol; antibiotic and MMP inhibitor) that have been studied earlier for treating vesicant-induced eye injuries. We also examined silibinin (100 ?g), a non-toxic natural flavanone found to be effective in treating SM analog-induced skin injuries in our earlier studies. Treatments of doxycycline + dexamethasone, and silibinin were more effective than doxycycline or dexamethasone alone in reversing NM-induced epithelial thickening, microbullae formation, apoptotic cell death, and MMP-9 elevation. However, dexamethasone and silibinin alone were more effective in reversing NM-induced VEGF levels. Doxycycline, dexamethasone and silibinin were all effective in reversing NM-induced COX-2 levels. Apart from therapeutic efficacy of doxycycline and dexamethasone, these results show strong multifunctional efficacy of silibinin in reversing NM-induced ocular injuries, which could help develop effective and safe therapeutics against ocular injuries by vesicants. -- Highlights: ? Established injury biomarkers in rabbit corneal culture with nitrogen mustard (NM) ? This NM model is a cost effective

  18. Exogenous contrast agents for thermoacoustic imaging: An investigation into the underlying sources of contrast

    SciTech Connect (OSTI)

    Ogunlade, Olumide Beard, Paul

    2015-01-15

    Purpose: Thermoacoustic imaging at microwave excitation frequencies is limited by the low differential contrast exhibited by high water content tissues. To overcome this, exogenous thermoacoustic contrast agents based on gadolinium compounds, iron oxide, and single wall carbon nanotubes have previously been suggested and investigated. However, these previous studies did not fully characterize the electric, magnetic, and thermodynamic properties of these agents thus precluding identification of the underlying sources of contrast. To address this, measurements of the complex permittivity, complex permeability, DC conductivity, and Grüneisen parameter have been made. These measurements allowed the origins of the contrast provided by each substance to be identified. Methods: The electric and magnetic properties of the contrast agents were characterized at 3 GHz using two rectangular waveguide cavities. The DC conductivity was measured separately using a conductivity meter. Thermoacoustic signals were then acquired and compared to those generated in water. Finally, 3D electromagnetic simulations were used to decouple the different contributions to the absorbed power density. Results: It was found that the gadolinium compounds provided appreciable electric contrast but not originating from the gadolinium itself. The contrast was either due to dissociation of the gadolinium salt which increased ionic conductivity or its nondissociated polar fraction which increased dielectric polarization loss or a combination of both. In addition, very high concentrations were required to achieve appreciable contrast, to the extent that the Grüneisen parameter increased significantly and became a source of contrast. Iron oxide particles were found to produce low but measurable dielectric contrast due to dielectric polarization loss, but this is attributed to the coating of the particles not the iron oxide. Single wall carbon nanotubes did not provide measurable contrast of any type

  19. Role of pH in metal adsorption from aqueous solutions containing chelating agents on chitosan

    SciTech Connect (OSTI)

    Wu, F.C.; Tseng, R.L.; Juang, R.S.

    1999-01-01

    The role of pH in adsorption of Cu(II) from aqueous solutions containing chelating agents on chitosan was emphasized. Four chelating agents including ethylenediaminetetraacetic acid (EDTA), citric acid, tartaric acid, and sodium gluconate were used. It was shown that the adsorption ability of Cu(II) on chitosan from its chelated solutions varied significantly with pH variations. The competition between coordination of Cu(II) with unprotonated chitosan and electrostatic interaction of the Cu(II) chelates with protonated chitosan took place because of the change in solution pH during adsorption. The maximum adsorption capacity was obtained within each optimal pH range determined from titration curves of the chelated solutions. Coordination of Cu(II) with the unprotonated chitosan was found to dominate at pH below such an optimal pH value.

  20. Chemistry of destroying chemical warfare agents in flame. Technical project report, April 1994-May 1995

    SciTech Connect (OSTI)

    Korobeinichev, O.P.; Chernov, A.A.; Shvartsberg, V.M.; Il`in, S.B.; Mokrushin, V.V.

    1995-05-01

    The goal of the research is to increase our understanding of flame chemistry of organophosphorus compounds (OPC). This class of chemicals includes chemical warfare agents. (CWAs) such as the nerve agents GB GD and VX, stockpiles of which in the United States and Former Soviet Union are scheduled for destruction by incineration or other technologies. Although high CWA destruction efficiency has been demonstrated in incinerator tests in the U.S. it is necessary to improve technology for achievement higher efficiency and lower level of pollutants. The knowledge of detailed destruction chemistry of the CWA and simulants can be obtained by studying the structure of flames, doped with simulants and CWA and by the development of the combustion model which will include the chemical mechanism of destroying CWA in flame. Alkyl phosphates and alkyl phosphonates are typical organophosphorus compounds, that are simulants of sarin.

  1. Effects of biradical deuteration on the performance of DNP: Towards better performing polarizing agents

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Perras, Frédéric A.; Reinig, Regina R.; Slowing, Igor I.; Sadow, Aaron D.; Pruski, Marek

    2015-11-20

    We study the effects of the deuteration of biradical polarizing agents on the efficiency of dynamic nuclear polarization (DNP) via the cross-effect. To this end, we synthesized a series of bTbK and TOTAPol biradicals with systematically increased deuterium substitution. The deuteration increases the radicals' relaxation time, thus contributing to a higher saturation factor and larger DNP enhancement, and reduces the pool of protons within the so-called spin diffusion barrier. Notably, we report that full or partial deuteration leads to improved DNP enhancement factors in standard samples, but also slows down the build-up of hyperpolarization. Improvements in DNP enhancements factors ofmore » up to 70% and time savings of up to 38% are obtained upon full deuteration. As a result, it is foreseen that this approach may be applied to other DNP polarizing agents thus enabling further sensitivity improvements.« less

  2. Portable Analytical Systems for On-Site Diagnosis of Exposure to Pesticides and Nerve Agents

    SciTech Connect (OSTI)

    Lin, Yuehe; Wang, Jun; Liu, Guodong; Timchalk, Chuck

    2009-12-01

    In this chapter, we summarize recent work in our laboratory on the development of sensitive portable analytical systems for use in on-site detection of exposure to organophosphate (OP) pesticides and chemical nerve agents. These systems are based on various nanomaterials functioning as transducers; recognition agents or labels and various elelectrochemical/immunoassay techniques. The studied nanomaterials included functionalized carbon nanotubes (CNT), zirconia nanoparticles (NPs) and quantum dots (QDs). Three biomarkers e.g. the free OPs, metabolites of OPs and protein-OP adducts in biological matrices have been employed for biomonitoring of OP exposure with our developed system. It has been found that the nanomaterial-based portable analytical systems have high sensitivity for the detection of the biomarkers, which suggest that these technologies offer great promise for the rapid and on-site detection and evaluation of OP exposure.

  3. Integrated Agent-Based and Production Cost Modeling Framework for Renewable Energy Studies: Preprint

    SciTech Connect (OSTI)

    Gallo, Giulia

    2015-10-07

    The agent-based framework for renewable energy studies (ARES) is an integrated approach that adds an agent-based model of industry actors to PLEXOS and combines the strengths of the two to overcome their individual shortcomings. It can examine existing and novel wholesale electricity markets under high penetrations of renewables. ARES is demonstrated by studying how increasing levels of wind will impact the operations and the exercise of market power of generation companies that exploit an economic withholding strategy. The analysis is carried out on a test system that represents the Electric Reliability Council of Texas energy-only market in the year 2020. The results more realistically reproduce the operations of an energy market under different and increasing penetrations of wind, and ARES can be extended to address pressing issues in current and future wholesale electricity markets.

  4. The use of software agents and distributed objects to integrate enterprises: Compatible or competing technologies?

    SciTech Connect (OSTI)

    Pancerella, C.M.

    1998-04-01

    Distributed object and software agent technologies are two integration methods for connecting enterprises. The two technologies have overlapping goals--interoperability and architectural support for integrating software components--though to date little or no integration of the two technologies has been made at the enterprise level. The primary difference between these two technologies is that distributed object technologies focus on the problems inherent in connecting distributed heterogeneous systems whereas software agent technologies focus on the problems involved with coordination and knowledge exchange across domain boundaries. This paper addresses the integration of these technologies in support of enterprise integration across organizational and geographic boundaries. The authors discuss enterprise integration issues, review their experiences with both technologies, and make recommendations for future work. Neither technology is a panacea. Good software engineering techniques must be applied to integrate an enterprise because scalability and a distributed software development team are realities.

  5. Disposal of chemical agents and munitions stored at Umatilla Depot Activity, Hermiston, Oregon

    SciTech Connect (OSTI)

    Zimmerman, G.P.; Hillsman, E.L.; Johnson, R.O.; Miller, R.L.; Patton, T.G.; Schoepfle, G.M.; Tolbert, V.R.; Feldman, D.L.; Hunsaker, D.B. Jr.; Kroodsma, R.L.; Morrissey, J.; Rickert, L.W.; Staub, W.P.; West, D.C.

    1993-02-01

    The Umatilla Depot Activity (UMDA) near Hermiston, Oregon, is one of eight US Army installations in the continental United States where lethal unitary chemical agents and munitions are stored, and where destruction of agents and munitions is proposed under the Chemical Stockpile Disposal Program (CSDP). The chemical agent inventory at UMDA consists of 11.6%, by weight, of the total US stockpile. The destruction of the stockpile is necessary to eliminate the risk to the public from continued storage and to dispose of obsolete and leaking munitions. In 1988 the US Army issued a Final Programmatic Environmental Impact Statement (FPEIS) for the CSDP that identified on-site disposal of agents and munitions as the environmentally preferred alternative (i.e., the alternative with the least potential to cause significant adverse impacts), using a method based on five measures of risk for potential human health and ecosystem/environmental effects; the effectiveness and adequacy of emergency preparedness capabilities also played a key role in the FPEIS selection methodology. In some instances, the FPEIS included generic data and assumptions that were developed to allow a consistent comparison of potential impacts among programmatic alternatives and did not include detailed conditions at each of the eight installations. The purpose of this Phase 1 report is to examine the proposed implementation of on-site disposal at UMDA in light of more recent and more detailed data than those included in the FPEIS. Specifically, this Phase 1 report is intended to either confirm or reject the validity of on-site disposal for the UMDA stockpile. Using the same computation methods as in the FPEIS, new population data were used to compute potential fatalities from hypothetical disposal accidents. Results indicate that onsite disposal is clearly preferable to either continued storage at UMDA or transportation of the UMDA stockpile to another depot for disposal.

  6. Solution mining dawsonite from hydrocarbon containing formations with a chelating agent

    DOE Patents [OSTI]

    Vinegar, Harold J. (Bellaire, TX)

    2009-07-07

    A method for treating an oil shale formation comprising dawsonite includes providing heat from one or more heaters to the formation to heat the formation. Hydrocarbon fluids are produced from the formation. At least some dawsonite in the formation is decomposed with the provided heat. A chelating agent is provided to the formation to dissolve at least some dawsonite decomposition products. The dissolved dawsonite decomposition products are produced from the formation.

  7. Kinetic study of treatment of wastewater contains food preservative agent by anaerobic baffled reactor : An overview

    SciTech Connect (OSTI)

    Sumantri, Indro; Purwanto,; Budiyono

    2015-12-29

    The characteristic of wastewater of food industries with preservative substances is high content of organic substances, degradable and high total suspended solid. High organic content in this waste forced the treatment is biologically and pointed out to anaerobic treatment. Anaerobic showed the better performance of degradation than aerobic for high content organic and also for toxic materials. During that day the treatment of food wastewater is aerobically which is high consume of energy required and high volume of sludge produced. The advantage of anaerobic is save high energy, less product of sludge, less requirement of nutrients of microorganism and high efficiency reduction of organic load. The high efficiency of reduction will reduce the load of further treatment, so that, the threshold limit based on the regulation would be easy to achieve. Research of treatment of wastewater of food industries would be utilized by both big scale industries and small industries using addition of preservative substances. The type reactor of anaerobic process is anaerobic baffled reactor that will give better contact between wastewater and microorganism in the sludge. The variables conducted in this research are the baffled configuration, sludge height, preservative agent contents, hydralic retention time and influence of micro nutrients. The respons of this research are the COD effluent, remaining preservative agent, pH, formation of volatile fatty acid and total suspended solid. The result of this research is kinetic model of the anaerobic baffled reactor, reaction kinetic of preservative agent degradation and technology of treatment wastewater contains preservative agent. The benefit of this research is to solve the treatment of wastewater of food industries with preservative substance in order to achieve wastewater limit regulation and also to prevent the environmental deterioration.

  8. Disposal of chemical agents and munitions stored at Anniston Army Depot, Anniston, Alabama

    SciTech Connect (OSTI)

    Hunsaker, D.B. Jr.; Zimmerman, G.P.; Hillsman, E.L.; Miller, R.L.; Schoepfle, G.M.; Johnson, R.O.; Tolbert, V.R.; Kroodsma, R.L.; Rickert, L.W.; Rogers, G.O.; Staub, W.P.

    1990-09-01

    The purpose of this Phase I report is to examined the proposed implementation of on-site disposal at Anniston Army Depot (ANAD) in light of more detailed and more recent data than those included in the Final Programmatic Environmental Impact Statement (EPEIS). Two principal issues are addressed: (1) whether or not the new data would result in identification of on-site disposal at ANAD as the environmentally preferred alternative (using the same selection method and data analysis tools as in the FPEIS), and (2) whether or not the new data indicate the presence of significant environmental resources that could be affected by on-site disposal at ANAD. In addition, a status report is presented on the maturity of the disposal technology (and now it could affect on-site disposal at ANAD). Inclusion of these more recent data into the FPEIS decision method resulted in confirmation of on-site disposal for ANAD. No unique resources with the potential to prevent or delay implementation of on-site disposal at ANAD have been identified. A review of the technology status identified four principal technology developments that have occurred since publication of the FPEIS and should be of value in the implementation of on-site disposal at ANAD: the disposal of nonlethal agent at Pine Bluff Arsenal, located near Pine Bluff, Arkansas; construction and testing of facilities for disposal of stored lethal agent at Johnston Atoll, located about 1300 km (800 miles) southwest of Hawaii in the Pacific Ocean; lethal agent disposal tests at the chemical agent pilot plant operations at Tooele Army Depot, located near Salt Lake City, Utah; and equipment advances. 18 references, 13 figs., 10 tabs.

  9. SMART II : the spot market agent research tool version 2.0.

    SciTech Connect (OSTI)

    North, M. J. N.

    2000-12-14

    Argonne National Laboratory (ANL) has worked closely with Western Area Power Administration (Western) over many years to develop a variety of electric power marketing and transmission system models that are being used for ongoing system planning and operation as well as analytic studies. Western markets and delivers reliable, cost-based electric power from 56 power plants to millions of consumers in 15 states. The Spot Market Agent Research Tool Version 2.0 (SMART II) is an investigative system that partially implements some important components of several existing ANL linear programming models, including some used by Western. SMART II does not implement a complete model of the Western utility system but it does include several salient features of this network for exploratory purposes. SMART II uses a Swarm agent-based framework. SMART II agents model bulk electric power transaction dynamics with recognition for marginal costs as well as transmission and generation constraints. SMART II uses a sparse graph of nodes and links to model the electric power spot market. The nodes represent power generators and consumers with distinct marginal decision curves and varying investment capital as well individual learning parameters. The links represent transmission lines with individual capacities taken from a range of central distribution, outlying distribution and feeder line types. The application of SMART II to electric power systems studies has produced useful results different from those often found using more traditional techniques. Use of the advanced features offered by the Swarm modeling environment simplified the creation of the SMART II model.

  10. A novel nanoparticle-based disposable electrochemical immunosensor for diagnosis of exposure to toxic organophosphorus agents

    SciTech Connect (OSTI)

    Lu, Donglai; Wang, Jun; Wang, Limin; Du, Dan; Timchalk, Charles; Barry, Richard C.; Lin, Yuehe

    2011-11-15

    We present a novel disposable electrochemical immunosensor for highly selective and sensitive detection of organophosphorylated butyrylcholinesterase (OP-BChE), a specific biomarker for exposure to toxic organophosphorus agents. In our new approach, the zirconia nanoparticles (ZrO-2) were employed to selectively capture the OP moiety of OP-BChE adducts, and followed by quantum dot (QD)-tagged anti-BChE antibodies for amplified quantification. The captured CdSe-QD tags can be sensitively detected by stripping voltammetry using in situ bismuth-plating method. The OP agent, diisopropylfluorophosphate (DFP), was selected to prepare OP-BChE adducts in various matrices. The formation of OP-BChE adducts in plasma sample was confirmed using mass spectroscopy. The developed electrochemical immunosensor demonstrates a highly linear voltammetric response over the range of 0.1 to 30 nM OP-BChE. Moreover, the immunosensor has been successfully applied for the detection of OP-BChE adducts in the plasma samples. This novel nanoparticle-based electrochemical immunosensor thus provides an alternative way for designing simple, fast, sensitive, and cost-effective sensing platform for on-site screening/evaluating exposure to a variety of OP agents.