National Library of Energy BETA

Sample records for regulations remain unchanged

  1. Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Merlevede, Jane; Droin, Nathalie; Qin, Tingting; Meldi, Kristen; Yoshida, Kenichi; Morabito, Margot; Chautard, Emilie; Auboeuf, Didier; Fenaux, Pierre; Braun, Thorsten; et al

    2016-02-24

    The cytidine analogues azacytidine and 5-aza-2’-deoxycytidine (decitabine) are commonly used to treat myelodysplastic syndromes, with or without a myeloproliferative component. It remains unclear whether the response to these hypomethylating agents results from a cytotoxic or an epigenetic effect. In this study, we address this question in chronic myelomonocytic leukaemia. We describe a comprehensive analysis of the mutational landscape of these tumours, combining whole-exome and whole-genome sequencing. We identify an average of 14 ± 5 somatic mutations in coding sequences of sorted monocyte DNA and the signatures of three mutational processes. Serial sequencing demonstrates that the response to hypomethylating agents ismore » associated with changes in DNA methylation and gene expression, without any decrease in the mutation allele burden, nor prevention of new genetic alteration occurence. Lastly, our findings indicate that cytosine analogues restore a balanced haematopoiesis without decreasing the size of the mutated clone, arguing for a predominantly epigenetic effect.« less

  2. Residential propane price is unchanged

    U.S. Energy Information Administration (EIA) Indexed Site

    13, 2014 Residential propane price is unchanged The average retail price for propane is 2.40 per gallon, down one-tenth of a cent from last week, based on the residential heating ...

  3. Residential heating oil prices virtually unchanged

    U.S. Energy Information Administration (EIA) Indexed Site

    heating oil prices virtually unchanged The average retail price for home heating oil fell 4-tenths of a penny from a week ago to 3.95 per gallon. That's down 8-tenths of a penny...

  4. Residential heating oil prices virtually unchanged

    U.S. Energy Information Administration (EIA) Indexed Site

    4 Residential heating oil prices virtually unchanged The average retail price for home heating oil rose 2-tenths of a cent from a week ago to 4.24 per gallon. That's up 8.2 cents ...

  5. Residential heating oil price virtually unchanged

    U.S. Energy Information Administration (EIA) Indexed Site

    heating oil price virtually unchanged The average retail price for home heating oil fell 1-tenth of a cent from a week ago to 2.13 per gallon. That's down 76 cents from a year ...

  6. Three-dimensional Invasion of Human Glioblastoma Cells Remains Unchanged by X-ray and Carbon Ion Irradiation In Vitro

    SciTech Connect (OSTI)

    Eke, Iris; Storch, Katja; Kaestner, Ina; Vehlow, Anne; Faethe, Christina; Mueller-Klieser, Wolfgang; Taucher-Scholz, Gisela; Temme, Achim; Schackert, Gabriele; Department of Radiation Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden

    2012-11-15

    Purpose: Cell invasion represents one of the major determinants that treatment has failed for patients suffering from glioblastoma. Contrary findings have been reported for cell migration upon exposure to ionizing radiation. Here, the migration and invasion capability of glioblastoma cells on and in collagen type I were evaluated upon irradiation with X-rays or carbon ions. Methods and Materials: Migration on and invasion in collagen type I were evaluated in four established human glioblastoma cell lines exposed to either X-rays or carbon ions. Furthermore, clonogenic radiation survival, proliferation (5-bromo-2-deoxyuridine positivity), DNA double-strand breaks ({gamma}H2AX/53BP1-positive foci), and expression of invasion-relevant proteins (eg, {beta}1 integrin, FAK, MMP2, and MMP9) were explored. Migration and invasion assays for primary glioblastoma cells also were carried out with X-ray irradiation. Results: Neither X-ray nor carbon ion irradiation affected glioblastoma cell migration and invasion, a finding similarly observed in primary glioblastoma cells. Intriguingly, irradiated cells migrated unhampered, despite DNA double-strand breaks and reduced proliferation. Clonogenic radiation survival was increased when cells had contact with extracellular matrix. Specific inhibition of the {beta}1 integrin or proliferation-associated signaling molecules revealed a critical function of JNK, PI3K, and p38 MAPK in glioblastoma cell invasion. Conclusions: These findings indicate that X-rays and carbon ion irradiation effectively reduce proliferation and clonogenic survival without modifying the migration and invasion ability of glioblastoma cells in a collagen type I environment. Addition of targeted agents against members of the MAPK and PI3K signaling axis to conventional chemoradiation therapy seems potentially useful to optimize glioblastoma therapy.

  7. U.S. gasoline prices unchanged (short version)

    U.S. Energy Information Administration (EIA) Indexed Site

    showed no movement from last week. The average price remained flat at 3.70 a gallon on Monday, based on the weekly price survey by the U.S. Energy Information Administration. This

  8. U.S. gasoline prices remain steady (short version)

    U.S. Energy Information Administration (EIA) Indexed Site

    average retail price for regular gasoline remained unchanged this week at 2.78 a gallon on Monday, based on the weekly price survey by the U.S. Energy Information Administration

  9. Remaining Challenges: Flicker

    Energy Savers [EERE]

    Naomi J. Miller, FIES, FIALD November 2015 DesignerSenior Staff Scientist Pacific Northwest National Laboratory Remaining Challenges: Flicker DOE SSL Workshop - Portland OR Dr....

  10. RCW - 68.50 Human Remains | Open Energy Information

    Open Energy Info (EERE)

    68.50 Human Remains Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: RCW - 68.50 Human RemainsLegal Published NA Year...

  11. Concentration and density changes at an electrode surface and the principle of unchanging total concentration

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Stephen W. Feldberg; Lewis, Ernie R.

    2016-02-17

    In this study, the principle of unchanging total concentration as described by Oldham and Feldberg [J. Phys. Chem. B, 103, 1699 (1999)] is invoked to analyze systems comprising a redox pair (Xz11 and Xz22) plus one or more non-electroactive species (Xz33,Xz44...Xzjmaxjmax) where Xzjj is the jth species with charge zj and concentration; cj. The principle states that if the diffusion coefficients for all species are identical and mass transport is governed by the Nernst-Planck expression, the total concentration does not change during any electrochemical perturbation, i.e.: Σjmaxj=1[Xzjj]=Σjmaxj=1 cj = SP With this principle we deduce the electrochemically induced difference betweenmore » the surface and bulk concentrations for each species. Those concentration differences are translated into density differences which are a function of the density of the solvent and of the concentration differences, molecular masses and the standard partial molar volumes of all species. Those density differences in turn can induce convection that will ultimately modify the observed current. However, we did not attempt to quantify details of the natural convection and current modification produced by those density differences.« less

  12. Acquisition Letters Remaining In Effect

    Broader source: Energy.gov [DOE]

    From Acquisition Letter (Acquisition Letters (AL) that remain in effect are identified below. All other previously issued Als have been superseded by a formal rule-making, incorporated into other guidance, and/or canceled.)

  13. Diesel prices remain fairly stable

    U.S. Energy Information Administration (EIA) Indexed Site

    Diesel prices remain fairly stable The U.S. average retail price for on-highway diesel fuel slightly fell to $3.85 a gallon on Monday. That's down 6-tenths of a penny from a week ago, based on the weekly price survey by the U.S. Energy Information Administration. Diesel prices were highest in the New England region at 3.99 a gallon, down 7-tenths of a penny from a week ago. Prices were lowest in the Gulf Coast region at 3.74 a gallon, down 2.2 cents

  14. Los Alamos supercomputer remains fastest in world

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    world Los Alamos supercomputer remains fastest in world The latest list of the TOP500 computers in the world continued to place the Roadrunner supercomputer as fastest in the world...

  15. AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT Acquisition Letters (AL) that remain in effect are identified below. All other...

  16. AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT AL 2014-06 ACQUISITION LETTERS REMAINING IN EFFECT Acquisition Letters (AL)...

  17. UC 9-8-309 - Human Remains | Open Energy Information

    Open Energy Info (EERE)

    9 - Human Remains Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: UC 9-8-309 - Human RemainsLegal Abstract Governs discovery of...

  18. ORISE: Study finds foreign doctorate recipients' stay rates remain high

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Study finds rate of foreign doctorate recipients staying in the United States remains high No evidence that visa restrictions are reducing stay rates, according to report FOR IMMEDIATE RELEASE Jan. 18, 2012 FY12-12 OAK RIDGE, Tenn.-The number of foreign students pursuing science and engineering doctorates in the United States continues to trend upward, and the rates at which they remain in the United States to work after graduation are at or near the highest levels observed for the various

  19. NNSA Partnership Successfully Removes All Remaining HEU from Uzbekistan |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration Partnership Successfully Removes All Remaining HEU from Uzbekistan September 29, 2015 WASHINGTON, DC - Today, the Department of Energy's National Nuclear Security Administration (DOE/NNSA) announced the successful return of the final 5 kilograms (approximately 11 pounds) of highly enriched uranium (HEU) spent fuel from the IIN-3M "Foton" research reactor in Tashkent, Uzbekistan to Russia. This is the eighth shipment of HEU from Uzbekistan

  20. United States Collaborates with Switzerland to Remove Last Remaining

    National Nuclear Security Administration (NNSA)

    Separated Plutonium | National Nuclear Security Administration United States Collaborates with Switzerland to Remove Last Remaining Separated Plutonium March 03, 2016 (WASHINGTON, D.C.) - The Department of Energy's National Nuclear Security Administration (NNSA), working in collaboration with the Government of Switzerland, announced that approximately 20 kilograms of separated plutonium have been transported from Switzerland to the United States. The successful transport of this plutonium

  1. Residential heating oil prices virtually unchanged

    U.S. Energy Information Administration (EIA) Indexed Site

    0, 2014 Residential heating oil price decreases The average retail price for home heating oil fell 1.9 cents from a week ago to 4.23 per gallon. That's up 5.1 cents from a year ...

  2. Residential heating oil prices virtually unchanged

    U.S. Energy Information Administration (EIA) Indexed Site

    4 Residential heating oil price decreases The average retail price for home heating oil fell 3.1 cents from a week ago to 4.20 per gallon. That's up 13.6 cents from a year ago, ...

  3. Residential heating oil prices virtually unchanged

    U.S. Energy Information Administration (EIA) Indexed Site

    9, 2014 Residential heating oil price decreases The average retail price for home heating oil fell 7.2 cents from a week ago to 4.12 per gallon. That's up 9.4 cents from a year ...

  4. Residential heating oil prices virtually unchanged

    U.S. Energy Information Administration (EIA) Indexed Site

    5, 2014 Residential heating oil price decreases The average retail price for home heating oil fell 1.6 cents from a week ago to 4.23 per gallon. That's up 14.9 cents from a year ...

  5. UC 9-9-403 - Native American Remains | Open Energy Information

    Open Energy Info (EERE)

    9-403 - Native American Remains Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: UC 9-9-403 - Native American RemainsLegal...

  6. UC 9-9-405 - Native American Remains Review | Open Energy Information

    Open Energy Info (EERE)

    5 - Native American Remains Review Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: UC 9-9-405 - Native American Remains...

  7. Medical Examiner/Coroner on the Handling of a Body/Human Remains...

    Office of Environmental Management (EM)

    Medical ExaminerCoroner on the Handling of a BodyHuman Remains that are Potentially Radiologically Contaminated Medical ExaminerCoroner on the Handling of a BodyHuman Remains...

  8. Microsoft Word - AL 2010-07 Acquistion Letters Remaining in Effect...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2010-07 Acquistion Letters Remaining in Effect May 2010 revision 1 June 2010 Microsoft Word - AL 2010-07 Acquistion Letters Remaining in Effect May 2010 revision 1 June 2010...

  9. A National Forum on Demand Response: What Remains to Be Done...

    Office of Environmental Management (EM)

    A National Forum on Demand Response: What Remains to Be Done to Achieve Its Potential A National Forum on Demand Response: What Remains to Be Done to Achieve Its Potential In July ...

  10. Recommendation 215: Recommendation on Remaining Legacy Materials on the Oak Ridge Reservation

    Broader source: Energy.gov [DOE]

    The Oak Ridge Site Specific Advisory Board approved the enclosed recommendation on remaining legacy materials on the Oak Ridge Reservation.

  11. Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Information Center Regulations Regulations Personnel Security Regulations Click Here FOIA Regulations Click Here Privacy Act Regulations Click Here Whistleblower Protection ...

  12. VOLTAGE REGULATOR

    DOE Patents [OSTI]

    Von Eschen, R.L.; Scheele, P.F.

    1962-04-24

    A transistorized voltage regulator which provides very close voitage regulation up to about 180 deg F is described. A diode in the positive line provides a constant voltage drop from the input to a regulating transistor emitter. An amplifier is coupled to the positive line through a resistor and is connected between a difference circuit and the regulating transistor base which is negative due to the difference in voltage drop across thc diode and the resistor so that a change in the regulator output causes the amplifier to increase or decrease the base voltage and current and incrcase or decrease the transistor impedance to return the regulator output to normal. (AEC)

  13. Current Size and Remaining Market Potential of the U.S. Energy Service

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Company Industry | Department of Energy Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry The study analyzes the size, growth and trends in the U.S. energy service company (ESCO) industry, drawing on information provided by industry executives and experts in 2012. The report also provides a preliminary estimate of remaining investment potential and annual blended

  14. Hand-Held Analyzer Quickly Detects Buried Human Remains - Energy Innovation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Portal Early Stage R&D Early Stage R&D Advanced Materials Advanced Materials Find More Like This Return to Search Hand-Held Analyzer Quickly Detects Buried Human Remains Oak Ridge National Laboratory Contact ORNL About This Technology Technology Marketing SummaryA lightweight hand-held analyzer invented by ORNL researchers uses visual and auditory cues to quickly alert investigators to the presence of buried human remains. The Lightweight Analyzer for Buried Remains And Decomposition

  15. Severe Weather Update: JLab Remains in HPC-2 for Nor'easter ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Severe Weather Update: JLab Remains in HPC-2 for Nor'easter & Hurricane Jefferson Lab's Emergency Management Severe Weather Team continues monitoring the forecasts and conditions...

  16. Decontamination and Management of Human Remains Following Incidents of Hazardous Chemical Release

    SciTech Connect (OSTI)

    Hauschild, Veronique; Watson, Annetta Paule; Bock, Robert Eldon

    2012-01-01

    Abstract Objective: To provide specific procedural guidance and resources for identification, assessment, control, and mitigation of compounds that may contaminate human remains resulting from chemical attack or release. Design: A detailed technical, policy, and regulatory review is summarized. Setting: Guidance is suitable for civilian or military settings where human remains potentially contaminated with hazardous chemicals may be present. Settings would include sites of transportation accidents, natural disasters, terrorist or military operations, mortuary affairs or medical examiner processing and decontamination points, and similar. Patients, Participants: While recommended procedures have not been validated with actual human remains, guidance has been developed from data characterizing controlled experiments with fabrics, materiel, and laboratory animals. Main Outcome Measure(s): Presentation of logic and specific procedures for remains management, protection and decontamination of mortuary affairs personnel, as well as decision criteria for determining when remains are sufficiently decontaminated so as to pose no chemical health hazard. Results: Established procedures and existing equipment/materiel available for decontamination and verification provide appropriate and reasonable means to mitigate chemical hazards from remains. Extensive characterization of issues related to remains decontamination indicates that supra-lethal concentrations of liquid chemical warfare agent VX may prove difficult to decontaminate and verify in a timely fashion. Specialized personnel can and should be called upon to assist with monitoring necessary to clear decontaminated remains for transport and processing. Conclusions: Once appropriate decontamination and verification have been accomplished, normal procedures for remains processing and transport to the decedent s family and the continental United States can be followed.

  17. HIGH PRESSURE GAS REGULATOR

    DOE Patents [OSTI]

    Ramage, R.W.

    1962-05-01

    A gas regulator operating on the piston and feedback principle is described. The device is particularly suitable for the delicate regulation of high pressure, i.e., 10,000 psi and above, gas sources, as well as being perfectly adaptable for use on gas supplies as low as 50 psi. The piston is adjustably connected to a needle valve and the movement of the piston regulates the flow of gas from the needle valve. The gas output is obtained from the needle valve. Output pressure is sampled by a piston feedback means which, in turn, regulates the movement of the main piston. When the output is other than the desired value, the feedback system initiates movement of the main piston to allow the output pressure to be corrected or to remain constant. (AEC)

  18. 2013-07 "Realign Remaining Milestones in the Consent Order" | Department of

    Office of Environmental Management (EM)

    Energy 7 "Realign Remaining Milestones in the Consent Order" 2013-07 "Realign Remaining Milestones in the Consent Order" It is the intent of this NNMCAB recommendation to encourage LANL to review all remaining tasks of the Consent Order and formulate a "Path Forward" for completion of these tasks in a manner which is both timely and most protective of human health and environment. This Path Forward shall be presented to the NNMCAB, NMED and public for comment,

  19. Calculation notes that support accident scenario and consequence development for the subsurface leak remaining subsurface accident

    SciTech Connect (OSTI)

    Ryan, G.W., Westinghouse Hanford

    1996-07-12

    This document supports the development and presentation of the following accident scenario in the TWRS Final Safety Analysis Report: Subsurface Leak Remaining Subsurface. The calculations needed to quantify the risk associated with this accident scenario are included within.

  20. Calculation notes that support accident scenario and consequence development for the subsurface leak remaining subsurface accident

    SciTech Connect (OSTI)

    Ryan, G.W., Westinghouse Hanford

    1996-09-19

    This document supports the development and presentation of the following accident scenario in the TWRS Final Safety Analysis Report: Subsurface Leak Remaining Subsurface. The calculations needed to quantify the risk associated with this accident scenario are included within.

  1. Natural gas inventories to remain high at end of winter heating...

    U.S. Energy Information Administration (EIA) Indexed Site

    Natural gas inventories to remain high at end of winter heating season Despite the jump in natural gas use to meet heating demand during the recent winter storm that walloped the ...

  2. Italy makes U-turn on nuclear power, but hurdles remain

    SciTech Connect (OSTI)

    2009-05-15

    A consortium consisting of ENEL and EDF in partnership with others including Edison, a major generator, and possibly a number of heavy industrial electricity users could invest in nuclear plants. But many technical, political, regulatory, and financial hurdles remain.

  3. MCA 22-3-801 - Human Skeletal Remains and Burial Site Protection...

    Open Energy Info (EERE)

    22-3-801 - Human Skeletal Remains and Burial Site Protection Act Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: MCA 22-3-801 -...

  4. Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry

    Broader source: Energy.gov [DOE]

    "This report contains information on Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry, prepared for the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy, Weatherization and Intergovernmental Program."

  5. White House: D'Agostino To Remain as NNSA Administrator | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy House: D'Agostino To Remain as NNSA Administrator White House: D'Agostino To Remain as NNSA Administrator September 3, 2009 - 12:00am Addthis WASHINGTON, DC - Today, President Barack Obama announced that Thomas Paul D'Agostino, Under Secretary for Nuclear Security of the Department of Energy and Administrator for Nuclear Security of the National Nuclear Security Administration, will continue serving in his current role. The following is a quote from the President included in today's

  6. A National Forum on Demand Response: What Remains to Be Done to Achieve Its

    Energy Savers [EERE]

    Potential | Department of Energy A National Forum on Demand Response: What Remains to Be Done to Achieve Its Potential A National Forum on Demand Response: What Remains to Be Done to Achieve Its Potential In July 2011, the Federal Energy Regulatory Commission's (FERC) staff and the Department of Energy (DOE) jointly submitted to Congress a required "Implementation Proposal for the National Action Plan on Demand Response." The Implementation Proposal was for FERC's June 2010

  7. Energy Department Issues Remaining $1.8 Billion in Loan Guarantees for

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Vogtle Advanced Nuclear Energy Project | Department of Energy Issues Remaining $1.8 Billion in Loan Guarantees for Vogtle Advanced Nuclear Energy Project Energy Department Issues Remaining $1.8 Billion in Loan Guarantees for Vogtle Advanced Nuclear Energy Project June 24, 2015 - 9:20am Addthis NEWS MEDIA CONTACT (202) 586-4940 To further support the construction of two advanced nuclear reactors at the Alvin W. Vogtle Electric Generating Plant, the Department of Energy announced today it will

  8. Grantee Performance Required to Release the Hold on Remaining 50% of Obligated Recovery Act Funds

    Broader source: Energy.gov [DOE]

    U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Weatherization Assistance Program Notice 10-05 deals with performance requirements for program grantees„states and U.S. territories„to receive the remaining 50% of obligated funds under the 2009 American Reinvestment and Recovery Act.

  9. Analysis of solids remaining following chemical cleaning in tank 6F

    SciTech Connect (OSTI)

    Poirier, Michael R.; Fondeur, Fernando F.; Missimer, David M.; Summer, Michael E.; Fink, Samuel D.

    2010-02-05

    Following chemical cleaning, a solid sample was collected and submitted to Savannah River National Laboratory (SRNL) for analysis. SRNL analyzed this sample by X-ray Diffraction (XRD) and scanning electron microscopy (SEM) to determine the composition of the solids remaining in Tank 6F and to assess the effectiveness of the chemical cleaning process.

  10. Evaluation of remaining life of the double-shell tank waste systems

    SciTech Connect (OSTI)

    Schwenk, E.B.

    1995-05-04

    A remaining life assessment of the DSTs (double-shell tanks) and their associated waste transfer lines, for continued operation over the next 10 years, was favorable. The DST assessment was based on definition of significant loads, evaluation of data for possible material degradation and geometric changes and evaluation of structural analyses. The piping assessment was based primarily on service experience.

  11. Acquisition Regulation

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... for DOE until such time as the DOE Acquisition Regulation (DEAR) is amended to ... 2015. The clause provides the necessary language to require M&O contractors (to include ...

  12. U.S. gasoline prices unchanged (short version)

    Gasoline and Diesel Fuel Update (EIA)

    (short version) The U.S. average retail price for regular gasoline fell for the 5 th week in a row to 3.52 a gallon on Monday. That's down 2.4 cents from a week ago and...

  13. U.S. gasoline prices unchanged (short version)

    U.S. Energy Information Administration (EIA) Indexed Site

    gasoline fell 4.2 cents from a week ago to 3.59 a gallon on Monday. This marks the first time since early April that prices have dipped below 3.60, based on the weekly price...

  14. U.S. gasoline prices unchanged (short version)

    U.S. Energy Information Administration (EIA) Indexed Site

    gasoline prices decrease (short version) The U.S. average retail price for regular gasoline fell to $3.68 a gallon on Monday. That's down 2.6 cents from a week ago, based on the weekly price survey by the U.S. Energy Information Administration. This is Amerine Woodyard, with EIA, in Washington

  15. Enhanced Contaminated Human Remains Pouch: initial development and preliminary performance assessments

    SciTech Connect (OSTI)

    Iseli, A.M.; Kwen, H.D.; Ul-Alam, M.; Balasubramanian, M.; Rajagopalan, S.

    2011-11-07

    The objective is to produce a proof of concept prototype Enhanced Contaminated Human Remains Pouch (ECHRP) with self-decontamination capability to provide increased protection to emergency response personnel. The key objective was to decrease the concentration of toxic chemicals through the use of an absorbent and reactive nanocellulose liner. Additionally, nanomaterials with biocidal properties were developed and tested as a 'stand-alone' treatment. The setting was a private company research laboratory. The main outcome measures were production of a functional prototype. A functional prototype capable of mitigating the threats due to sulfur mustard, Soman, and a large variety of liquid and vapor toxic industrial chemicals was produced. Stand-alone biocidal treatment efficacy was validated. The ECHRP provides superior protection from both chemical and biological hazards to various emergency response personnel and human remains handlers.

  16. Acquisition Regulation

    Energy Savers [EERE]

    5 Date 05/12/2015 ACQUISITION LETTER This Acquisition Letter is issued under the authority of the DOE and NNSA Senior Procurement Executives. Acquisition Letters (AL) that remain in effect are identified below. All other previously issued ALs have been superseded by a formal rule-making, incorporated into other guidance, and/or canceled. ** ************** ACQUISITION LETTERS REMAINING IN EFFECT NUMBER DATE SUBJECT 93-4 04/07/1993 Displaced Workers Benefits Program 94-19 12/09/1994 Basic Labor

  17. Method and apparatus to predict the remaining service life of an operating system

    DOE Patents [OSTI]

    Greitzer, Frank L.; Kangas, Lars J.; Terrones, Kristine M.; Maynard, Melody A.; Pawlowski, Ronald A. , Ferryman; Thomas A.; Skorpik, James R.; Wilson, Bary W.

    2008-11-25

    A method and computer-based apparatus for monitoring the degradation of, predicting the remaining service life of, and/or planning maintenance for, an operating system are disclosed. Diagnostic information on degradation of the operating system is obtained through measurement of one or more performance characteristics by one or more sensors onboard and/or proximate the operating system. Though not required, it is preferred that the sensor data are validated to improve the accuracy and reliability of the service life predictions. The condition or degree of degradation of the operating system is presented to a user by way of one or more calculated, numeric degradation figures of merit that are trended against one or more independent variables using one or more mathematical techniques. Furthermore, more than one trendline and uncertainty interval may be generated for a given degradation figure of merit/independent variable data set. The trendline(s) and uncertainty interval(s) are subsequently compared to one or more degradation figure of merit thresholds to predict the remaining service life of the operating system. The present invention enables multiple mathematical approaches in determining which trendline(s) to use to provide the best estimate of the remaining service life.

  18. Prognostication of LED Remaining Useful Life and Color Stability in the Presence of Contamination

    SciTech Connect (OSTI)

    Lall, Pradeep; Zang, Hao; Davis, J Lynn

    2015-06-22

    The reliability of LED products may be affected by both luminous flux drop and color shift. Previous research on the topic focuses on either luminous maintenance or color shift. However, luminous flux degradation usually takes very long time to observe in LEDs under normal operating conditions. In this paper, the impact of a VOC (volatile organic compound) contaminated luminous flux and color stability are examined. As a result, both luminous degradation and color shift had been recorded in a short time. Test samples are white, phosphorconverted, high-power LED packages. Absolute radiant flux is measured with integrating sphere system to calculate the luminous flux. Luminous flux degradation and color shift distance were plotted versus aging time to show the degradation pattern. A prognostic health management (PHM) method based on the state variables and state estimator have been proposed in this paper. In this PHM framework, unscented kalman filter (UKF) was deployed as the carrier of all states. During the estimation process, third order dynamic transfer function was used to implement the PHM framework. Both of the luminous flux and color shift distance have been used as the state variable with the same PHM framework to exam the robustness of the method. Predicted remaining useful life is calculated at every measurement point to compare with the tested remaining useful life. The result shows that state estimator can be used as the method for the PHM of LED degradation with respect to both luminous flux and color shift distance. The prediction of remaining useful life of LED package, made by the states estimator and data driven approach, falls in the acceptable errorbounds (20%) after a short training of the estimator.

  19. Liquid ash corrosion, remaining life estimation and superheater/reheater replacement strategy in coal fired boilers

    SciTech Connect (OSTI)

    Alice, J.A.; Janiszewski, J.A.

    1985-01-01

    The liquid ash corrosion of superheater and reheater tubing in coal fired boilers is commonly accepted to be caused by the action of liquid sodium and potassium iron trisulfates Na/sub 3/Fe(SO/sub 4/) and K/sub 3/Fe(SO/sub 4/)/sub 3/. These species melt at temperatures between 1030/sup 0/F and 1160/sup 0/F (555-625/sup 0/C) depending on the relative amounts of sodium and potassium. Rapid tube wastage begins when the tube metal temperature reaches the trisulfate melting point. The key to improved availability in fossil boilers is to identify and replace, during a planned outage, tubes which are likely to fail before the next planned outage. The authors have developed a computerized method for estimating the remaining life of superheater/reheater tubes based on accelerated liquid ash corrosion. The scheme of analysis employs the following logic: (1) measurement of tube wastage from several removed samples, (2) estimation of tube metal temperature from I.D. scale thickness and thermocouple data, (3) estimation of trisulfate melting point from chemical analysis of the ash deposit and (4) using the computer model to calculate remaining life as a function of tube wastage rate metal temperature. The practical application of this strategy is presented for a coal fired boiler in the GPU system.

  20. Neutron measurements of the fuel remaining in the TMI II once-through steam generators (OTSG'S)

    SciTech Connect (OSTI)

    Geelhood, B.D.; Abel, K.H.

    1989-02-01

    Polypropylene tubes containing a string of 18 copper rods were inserted into the lower head region and each J-leg of the two once-through steam generators (OTSG) of the unit two reactor at Three Mile Island. The object was to measure the neutron flux present in those regions and estimate the amount of residual fuel remaining in each OTSG. The neutron flux from any residual fuel induces a radioisotope, /sup 64/Cu, in the copper coupons. The /sup 64/Cu activity is detected by coincidence counting the two 511-keV gamma rays produced by the annihilation of the positron emitted in the decay of /sup 64/Cu. The copper coupons were placed between two 6-inch diameter, 6-inch long NaI(Tl) crystals and the electronics produced a coincidence count whenever the two gamma rays were uniquely detected. The net coincidence count is proportional to the amount of /sup 64/Cu activity in the coupon. This document discusses calculation methods, statistical methods, and results of this research. 3 figs., 30 tabs.

  1. Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants – Interim Study FY13

    SciTech Connect (OSTI)

    Simmons, Kevin L.; Fifield, Leonard S.; Westman, Matthew P.; Ramuhalli, Pradeep; Pardini, Allan F.; Tedeschi, Jonathan R.; Jones, Anthony M.

    2013-09-27

    The most important criterion for cable performance is its ability to withstand a design-basis accident. With nearly 1000 km of power, control, instrumentation, and other cables typically found in an NPP, it would be a significant undertaking to inspect all of the cables. Degradation of the cable jacket, electrical insulation, and other cable components is a key issue that is likely to affect the ability of the currently installed cables to operate safely and reliably for another 20 to 40 years beyond the initial operating life. The development of one or more nondestructive evaluation (NDE) techniques and supporting models that could assist in determining the remaining life expectancy of cables or their current degradation state would be of significant interest. The ability to nondestructively determine material and electrical properties of cable jackets and insulation without disturbing the cables or connections has been deemed essential. Currently, the only technique accepted by industry to measure cable elasticity (the gold standard for determining cable insulation degradation) is the indentation measurement. All other NDE techniques are used to find flaws in the cable and do not provide information to determine the current health or life expectancy. There is no single NDE technique that can satisfy all of the requirements needed for making a life-expectancy determination, but a wide range of methods have been evaluated for use in NPPs as part of a continuous evaluation program. The commonly used methods are indentation and visual inspection, but these are only suitable for easily accessible cables. Several NDE methodologies using electrical techniques are in use today for flaw detection but there are none that can predict the life of a cable. There are, however, several physical and chemical ptoperty changes in cable insulation as a result of thermal and radiation damage. In principle, these properties may be targets for advanced NDE methods to provide early warning of aging and degradation. Examples of such key indicators include changes in chemical structure, mechanical modulus, and dielectric permittivity. While some of these indicators are the basis of currently used technologies, there is a need to increase the volume of cable that may be inspected with a single measurement, and if possible, to develop techniques for in-situ inspection (i.e., while the cable is in operation). This is the focus of the present report.

  2. Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations Regulations Security Reviews Click Here FOIA Appeals Click Here Whistleblower Protection Click Here Procedural Regulations Click Here Browse Title 10 Energy Click Here

  3. Charge regulation circuit

    DOE Patents [OSTI]

    Ball, Don G. (Livermore, CA)

    1992-01-01

    A charge regulation circuit provides regulation of an unregulated voltage supply in the range of 0.01%. The charge regulation circuit is utilized in a preferred embodiment in providing regulated voltage for controlling the operation of a laser.

  4. Regulation of Meiotic Recombination

    SciTech Connect (OSTI)

    Gregory p. Copenhaver

    2011-11-09

    Meiotic recombination results in the heritable rearrangement of DNA, primarily through reciprocal exchange between homologous chromosome or gene conversion. In plants these events are critical for ensuring proper chromosome segregation, facilitating DNA repair and providing a basis for genetic diversity. Understanding this fundamental biological mechanism will directly facilitate trait mapping, conventional plant breeding, and development of genetic engineering techniques that will help support the responsible production and conversion of renewable resources for fuels, chemicals, and the conservation of energy (1-3). Substantial progress has been made in understanding the basal recombination machinery, much of which is conserved in organisms as diverse as yeast, plants and mammals (4, 5). Significantly less is known about the factors that regulate how often and where that basal machinery acts on higher eukaryotic chromosomes. One important mechanism for regulating the frequency and distribution of meiotic recombination is crossover interference - or the ability of one recombination event to influence nearby events. The MUS81 gene is thought to play an important role in regulating the influence of interference on crossing over. The immediate goals of this project are to use reverse genetics to identify mutants in two putative MUS81 homologs in the model plant Arabidopsis thaliana, characterize those mutants and initiate a novel forward genetic screen for additional regulators of meiotic recombination. The long-term goal of the project is to understand how meiotic recombination is regulated in higher eukaryotes with an emphasis on the molecular basis of crossover interference. The ability to monitor recombination in all four meiotic products (tetrad analysis) has been a powerful tool in the arsenal of yeast geneticists. Previously, the qrt mutant of Arabidopsis, which causes the four pollen products of male meiosis to remain attached, was developed as a facile system for assaying recombination using tetrad analysis in a higher eukaryotic system (6). This system enabled the measurement of the frequency and distribution of recombination events at a genome wide level in wild type Arabidopsis (7), construction of genetic linkage maps which include positions for each centromere (8), and modeling of the strength and pattern of interference (9). This proposal extends the use of tetrad analysis in Arabidopsis by using it as the basis for assessing the phenotypes of mutants in genes important for recombination and the regulation of crossover interference and performing a novel genetic screen. In addition to broadening our knowledge of a classic genetic problem - the regulation of recombination by crossover interference - this proposal also provides broader impact by: generating pedagogical tools for use in hands-on classroom experience with genetics, building interdisciplinary collegial partnerships, and creating a platform for participation by junior scientists from underrepresented groups. There are three specific aims: (1) Isolate mutants in Arabidopsis MUS81 homologs using T-DNA and TILLING (2) Characterize recombination levels and interference in mus81 mutants (3) Execute a novel genetic screen, based on tetrad analysis, for genes that regulate meiotic recombination

  5. Regulators, Requirements, Statutes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulators, Requirements, Statutes Regulators, Requirements, Statutes The Laboratory must comply with environmental laws and regulations that apply to Laboratory operations. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email Environmental laws and regulations LANL complies with more than 30 state and federal regulations and policies designed to protect human health and the environment. Regulators Regulators Environmental

  6. GAO-07-1036, CRITICAL INFRASTRUCTURE PROTECTION: Multiple Efforts to Secure Control Systems Are Under Way, but Challenges Remain

    Energy Savers [EERE]

    Congressional Requesters CRITICAL INFRASTRUCTURE PROTECTION Multiple Efforts to Secure Control Systems Are Under Way, but Challenges Remain September 2007 GAO-07-1036 What GAO Found United States Government Accountability Office Why GAO Did This Study Highlights Accountability Integrity Reliability September 2007 CRITICAL INFRASTRUCTURE PROTECTION Multiple Efforts to Secure Control Systems Are Under Way, but Challenges Remain Highlights of GAO-07-1036, a report to congressional requesters

  7. An overview of remaining life assessment methods for high temperature components operating in the power and petrochemical industries

    SciTech Connect (OSTI)

    Middleton, C.J.; Townsend, R.D.

    1998-12-31

    The capability to assess the secure remaining life of components operating in the creep range, thereby assuring integrity between inspection intervals, has become a major factor in the economic operation of power and petrochemical plant which has passed the original design life, frequently by a considerable margin. An overview is given of the nature of remaining life assessment and examples given of methods developed for headers, seam-welded pipe and fired heaters. The more common problems associated with weldments are also reviewed.

  8. An evaluation of known remaining oil resources in the state of California: Project on advanced oil recovery and the states. Volume 2

    SciTech Connect (OSTI)

    1993-11-01

    The Interstate Oil and Gas Compact Commission (IOGCC) has conducted a series of studies to evaluate the known, remaining oil resource in twenty-three (23) states. The primary objective of die IOGCC`s effort is to examine the potential impact of an aggressive and focused program of research, development, and demonstration (RD&D) and technology transfer on future oil recovery in the United States. As part of a larger effort by the IOGCC, this report focuses on the potential economic benefits of improved oil recovery in the state of California. Individual reports for seven other oil producing states and a national report have been separately published by the IOGCC. Several major technical insights for state and Federal policymakers and regulators can be reached from this analysis. Overall, well abandonments and more stringent environmental regulations could limit economic access to the nation`s known, remaining oil resource. The high risk of near-term abandonment and the significant benefits of future application of improved oil recovery technoloy, clearly point to a need for more aggressive transfer of currently available technologies to domestic oil producers. Development and application of advanced oil recovery technologies could leave even greater benefits to the nation. A collaborative, focused RD&D effort, integrating the resources and expertise of industry, state and local governments, and the Federal government, is clearly warranted. With effective RD&D and a program of aggressive technology transfer to widely disseminate its results, California oil production could be maximized. The resulting increase and improvement in production rates, employment, operator profits, state and Federal tax revenues, energy security will benefit both the state of California and the nation as a whole.

  9. Confusion reigns over industrial stormwater regulations

    SciTech Connect (OSTI)

    Bishop, J.

    1993-01-01

    More than five years after Congress mandated controls for industrial and municipal stormwater discharges, many in the regulated community remain unclear about how the rules apply to them. The regulations' progress since the 1987 CWA amendments opened the door for their development often has been shaky and marked by setbacks. According to a federal appeals court decision issued last summer, that struggle is likely to continue. Although the original stormwater rules issued by EPA in November 1990 appeared to focus on heavy manufacturing facilities, as well as municipalities, the appellate court cleared a path that could draw light industrial plants and small construction sites within the regulations' domain. The rules in dispute bring under their umbrella any stormwater discharges associated with industrial activity to surface waters or municipal storm sewer systems. However, the regulations distinguish between facilities engaged in heavy industry and light, or enclosed industrial facilities, based on the probability that stormwater discharges will be contaminated and require regulation.

  10. Apparatus for determining past-service conditions and remaining life of thermal barrier coatings and components having such coatings

    DOE Patents [OSTI]

    Srivastava, Alok Mani; Setlur, Anant Achyut; Comanzo, Holly Ann; Devitt, John William; Ruud, James Anthony; Brewer, Luke Nathaniel

    2004-05-04

    An apparatus for determining past-service conditions and/or remaining useful life of a component of a combustion engine and/or a thermal barrier coating ("TBC") of the component comprises a radiation source that provides the exciting radiation to the TBC to excite a photoluminescent ("PL") material contained therein, a radiation detector for detecting radiation emitted by the PL material, and means for relating a characteristic of an emission spectrum of the PL material to the amount of a crystalline phase in the TBC, thereby inferring the past-service conditions or the remaining useful life of the component or the TBC.

  11. Multimedia regulated chemicals

    SciTech Connect (OSTI)

    Lee, C.C.; Huffman, G.L.; Mao, Y.L.

    1999-10-01

    This article examines those chemicals that are listed in either environmental laws or regulations. Its objective is to help readers determine which laws regulate what types of chemicals and which types of chemicals are regulated by what laws. It is multimedia in scope, describing the various chemicals that are regulated in the different media (i.e., air, water, or land).

  12. Implementation of Remaining Useful Lifetime Transformer Models in the Fleet-Wide Prognostic and Health Management Suite

    SciTech Connect (OSTI)

    Agarwal, Vivek; Lybeck, Nancy J.; Pham, Binh; Rusaw, Richard; Bickford, Randall

    2015-02-01

    Research and development efforts are required to address aging and reliability concerns of the existing fleet of nuclear power plants. As most plants continue to operate beyond the license life (i.e., towards 60 or 80 years), plant components are more likely to incur age-related degradation mechanisms. To assess and manage the health of aging plant assets across the nuclear industry, the Electric Power Research Institute has developed a web-based Fleet-Wide Prognostic and Health Management (FW-PHM) Suite for diagnosis and prognosis. FW-PHM is a set of web-based diagnostic and prognostic tools and databases, comprised of the Diagnostic Advisor, the Asset Fault Signature Database, the Remaining Useful Life Advisor, and the Remaining Useful Life Database, that serves as an integrated health monitoring architecture. The main focus of this paper is the implementation of prognostic models for generator step-up transformers in the FW-PHM Suite. One prognostic model discussed is based on the functional relationship between degree of polymerization, (the most commonly used metrics to assess the health of the winding insulation in a transformer) and furfural concentration in the insulating oil. The other model is based on thermal-induced degradation of the transformer insulation. By utilizing transformer loading information, established thermal models are used to estimate the hot spot temperature inside the transformer winding. Both models are implemented in the Remaining Useful Life Database of the FW-PHM Suite. The Remaining Useful Life Advisor utilizes the implemented prognostic models to estimate the remaining useful life of the paper winding insulation in the transformer based on actual oil testing and operational data.

  13. Remaining Sites Verification Package for 132-DR-1, 1608-DR Effluent Pumping Station, Waste Site Reclassification Form 2005-035

    SciTech Connect (OSTI)

    R. A. Carlson

    2005-09-22

    Radiological characterization, decommissioning and demolition of the 132-DR-1 site, 1608-DR Effluent Pumping Station was performed in 1987. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. Residual concentrations support future land uses that can be represented by a rural-residential scenario and pose no threat to groundwater or the Columbia River based on RESRAD modeling.

  14. An evaluation of known remaining oil resources in the state of California. Volume 2, Project on Advanced Oil Recovery and the States

    SciTech Connect (OSTI)

    Not Available

    1994-10-01

    The Interstate Oil and Gas Compact Commission (IOGCC) has conducted a series of studies to evaluate the known, remaining oil resource in twenty-three (23) states. The primary objective of the IOGCC`s effort is to examine the potential impact of an aggressive and focused program of research, development, and demonstration (RD&D) and technology transfer on future oil recovery in the United States. As a part of this larger effort by the IOGCC, this report focuses on the potential economic benefits of improved oil recovery in the state of California. Individual reports for seven other oil producing states and a national report have been separately published by the IOGCC. The analysis presented in this report is based on the databases and models available in the Tertiary Oil Recovery Information System (TORIS). Overall, well abandonments and more stringent environmental regulations could limit economic access to California`s known, remaining oil resource. The high risk of near-term abandonment and the significant benefits of future application of improved oil recovery technology, clearly point to a need for more aggressive transfer of currently available technologies to oil producers. Development and application of advanced oil recovery technologies could have even greater benefits to the state and the nation. A collaborative, focused RD&D effort, integrating the resources and expertise of industry, state and local governments, and the Federal government, is clearly warranted. With effective RD&D and a program of aggressive technology transfer to widely disseminate its results, California oil production could be maximized. The resulting increase in production rates, employment, operator profits, state and Federal tax revenues, and energy security will benefit both the state of California and the nation as a whole.

  15. Analysis of long-term impacts of TRU waste remaining at generator/storage sites for No Action Alternative 2

    SciTech Connect (OSTI)

    Buck, J.W.; Bagaasen, L.M.; Bergeron, M.P.; Streile, G.P.

    1997-09-01

    This report is a supplement to the Waste Isolation Pilot Plant Disposal-Phase Final Supplemental Environmental Impact Statement (SEIS-II). Described herein are the underlying information, data, and assumptions used to estimate the long-term human-health impacts from exposure to radionuclides and hazardous chemicals in transuranic (TRU) waste remaining at major generator/storage sites after loss of institutional control under No Action Alternative 2. Under No Action Alternative 2, TRU wastes would not be emplaced at the Waste Isolation Pilot Plant (WIPP) but would remain at generator/storage sites in surface or near-surface storage. Waste generated at smaller sites would be consolidated at the major generator/storage sites. Current TRU waste management practices would continue, but newly generated waste would be treated to meet the WIPP waste acceptance criteria. For this alternative, institutional control was assumed to be lost 100 years after the end of the waste generation period, with exposure to radionuclides and hazardous chemicals in the TRU waste possible from direct intrusion and release to the surrounding environment. The potential human-health impacts from exposure to radionuclides and hazardous chemicals in TRU waste were analyzed for two different types of scenarios. Both analyses estimated site-specific, human-health impacts at seven major generator/storage sites: the Hanford Site (Hanford), Idaho National Engineering and Environmental Laboratory (INEEL), Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Oak Ridge National Laboratory (ORNL), Rocky Flats Environmental Technology Site (RFETS), and Savannah River Site (SRS). The analysis focused on these seven sites because 99 % of the estimated TRU waste volume and inventory would remain there under the assumptions of No Action Alternative 2.

  16. Remaining Sites Verification Package for the 100-B-24 Spillway, Waste Site Reclassification Form 2006-051

    SciTech Connect (OSTI)

    L. M. Dittmer

    2006-09-18

    The 100-B-24 Spillway is a spillway that was designed to serve as an emergency discharge point for the 116-B-7 outfall in the event that the 100-B-15 river effluent pipelines were blocked, damaged, or undergoing maintenance. The site meets the remedial action objectives specified in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  17. Dependence of waterflood remaining oil saturation on relative permeability, capillary pressure, and reservoir parameters in mixed wet, turbidite sands

    SciTech Connect (OSTI)

    Hirasaki, G.J.

    1995-12-31

    The dependence of waterflood oil recovery on relative permeability, capillary pressure, and reservoir parameters was investigated by numerical simulation. The relative permeability and capillary pressure curves were based on laboratory measurements on unconsolidated sands and were evaluated for water-wet and mixed wet states. The reservoir model was a prototype turbidite sand with a range of thickness and permeability values. The economic oil recovery was based on an economic limit water cut of 50%. The remaining oil saturation in the swept region for the water-wet cases was close to the residual oil saturation. The remaining oil saturation of the mixed wet cases ranged from low values near the residual oil saturation to far above the residual oil saturation. It is dependent on the reservoir parameters that govern: (1) the vertical {open_quotes}film surface drainage{close_quotes} of oil by gravity, (2) accumulation of a high oil saturation and thus a high relative permeability under the cap rock, (3) updip migration of the oil that accumulated under the cap rock. The dependence on the reservoir parameters can be summarized by dimensionless groups. There is a dimensionless time for the vertical displacement of oil by gravity. The accumulation of a high oil saturation under the cap rock is dependent on the ratio of the capillary transition zone and the sand thickness. The updip migration is dependent on a combination of the gravity number and the end point mobility ratio.

  18. Load regulating expansion fixture

    DOE Patents [OSTI]

    Wagner, L.M.; Strum, M.J.

    1998-12-15

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils is disclosed. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located therebetween. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components. 1 fig.

  19. Load regulating expansion fixture

    DOE Patents [OSTI]

    Wagner, Lawrence M.; Strum, Michael J.

    1998-01-01

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located therebetween. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components.

  20. Remaining Sites Verification Package for the 100-F-54 Animal Farm Pastures, Waste Site Reclassification Form 2008-015

    SciTech Connect (OSTI)

    J. M. Capron

    2008-04-17

    The 100-F-54 waste site, part of the 100-FR-2 Operable Unit, is the soil associated with the former pastures for holding domestic farm animals used in experimental toxicology studies. Evaluation of historical information resulted in identification of the experimental animal farm pastures as having potential residual soil contamination due to excrement from experimental animals. The 100-F-54 animal farm pastures confirmatory sampling results support a reclassification of this site to No Action. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  1. Pressure reducing regulator

    DOE Patents [OSTI]

    Whitehead, John C. (Davis, CA); Dilgard, Lemoyne W. (Willits, CA)

    1995-01-01

    A pressure reducing regulator that controls its downstream or outlet pressure to a fixed fraction of its upstream or inlet pressure. The regulator includes a housing which may be of a titanium alloy, within which is located a seal or gasket at the outlet end which may be made of annealed copper, a rod, and piston, each of which may be made of high density graphite. The regulator is insensitive to temperature by virtue of being without a spring or gas sealed behind a diaphragm, and provides a reference for a system in which it is being used. The rod and piston of the regulator are constructed, for example, to have a 1/20 ratio such that when the downstream pressure is less than 1/20 of the upstream pressure the regulator opens and when the downstream pressure exceeds 1/20 of the upstream pressure the regulator closes.

  2. Pressure reducing regulator

    DOE Patents [OSTI]

    Whitehead, J.C.; Dilgard, L.W.

    1995-10-10

    A pressure reducing regulator that controls its downstream or outlet pressure to a fixed fraction of its upstream or inlet pressure is disclosed. The regulator includes a housing which may be of a titanium alloy, within which is located a seal or gasket at the outlet end which may be made of annealed copper, a rod, and piston, each of which may be made of high density graphite. The regulator is insensitive to temperature by virtue of being without a spring or gas sealed behind a diaphragm, and provides a reference for a system in which it is being used. The rod and piston of the regulator are constructed, for example, to have a 1/20 ratio such that when the downstream pressure is less than 1/20 of the upstream pressure the regulator opens and when the downstream pressure exceeds 1/20 of the upstream pressure the regulator closes. 10 figs.

  3. Resources for Utility Regulators

    SciTech Connect (OSTI)

    SEE Action

    2012-06-01

    Provides a summary of State and Local Energy Efficiency Action Network (SEE Action) information resources available to utility regulators, organized by topic.

  4. Policy and Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations Policy and Regulations map-1019833_960_720.jpg

  5. Report for Westinghouse Hanford Company: Makeup procedures and characterization data for modified DSSF and modified remaining inventory simulated tank waste

    SciTech Connect (OSTI)

    Lokken, R.O.

    1996-03-01

    The majority of defense wastes generated from reprocessing spent reactor fuel at Hanford are stored in underground Double-Shell Tanks (DST) and in older Single-Shell Tanks (SST). The Tank Waste Remediation System (TWRS) Program has the responsibility of safely managing and immobilizing these tank wastes for disposal. A reference process flowsheet is being developed that includes waste retrieval, pretreatment, and vitrification. Melter technologies for vitrifying low-level tank wastes are being evaluated by Westinghouse Hanford Company. Chemical simulants are being used in the technology testing. For the first phase of low-level waste (LLW) vitrification simulant development, two waste stream compositions were investigated. The first waste simulant was based on the analyses of six tanks of double-shell slurry feed (DSSF) waste and on the projected composition of the wastes exiting the pretreatment operations. A simulant normalized to 6 M sodium was based on the anticipated chemical concentrations after ion exchange and initial separations. The same simulant concentrated to 10 M sodium would represent a waste that had been concentrated by evaporation to reduce the overall volume. The second LLW simulant, referred to as the remaining inventory (RI), included wastes not included in the DSSF tanks and the projected LLW fraction of single-shell tank wastes.

  6. Remaining Sites Verification Package for the 100-F-50 Stormwater Runoff Culvert, Waste Site Reclassification Form 2007-001

    SciTech Connect (OSTI)

    J. M. Capron

    2008-04-15

    The 100-F-50 waste site, part of the 100-FR-2 Operable Unit, is a steel stormwater runoff culvert that runs between two railroad grades in the south-central portion of the 100-F Area. The culvert exiting the west side of the railroad grade is mostly encased in concrete and surrounded by a concrete stormwater collection depression partially filled with soil and vegetation. The drain pipe exiting the east side of the railroad grade embankment is partially filled with soil and rocks. The 100-F-50 stormwater diversion culvert confirmatory sampling results support a reclassification of this site to no action. The current site conditions achieve the remedial action objectives and corresponding remedial action goals established in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  7. WIPP Documents - Federal Regulations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Federal Regulations 40 CFR Part 191 Environmental radiation protection standards for management and disposal of spent nuclear fuel, high-level and transuranic radioactive wastes. 40 CFR Part 194 Criteria for the certification and re-certification of the Waste Isolation Pilot Plant's compliance with the 40 CFR Part 191 disposal regulations.

  8. Dependence of waterflood remaining oil saturation on relative permeability, capillary pressure, and reservoir parameters in mixed-wet turbidite sands

    SciTech Connect (OSTI)

    Hirasaki, G.J.

    1996-05-01

    The dependence of waterflood oil recovery on relative permeability, capillary pressure, and reservoir parameters was investigated by numerical simulation. The relative permeability and capillary pressure curves were based on laboratory measurements on unconsolidated sands. The water-wet case is based on the assumption that the system is water-wet and measurements were made with refined oil. The mixed-wet case assumed that the system is mixed-wet and restored-state measurements were made with crude oil. The reservoir model was a prototype turbidite sand with a range of thickness and permeability values. The economic oil recovery was based on an economic limit water cut of 50%. The remaining oil saturation (ROS) in the swept region for the water-wet cases was close to the residual oil saturation. The ROS of the mixed-wet cases ranged from low values near the residual oil saturation to far above the residual oil saturation. It is dependent on the reservoir parameters that govern (1) the vertical film surface drainage of oil by gravity, (2) accumulation of a high oil saturation and thus a high relative permeability under the caprock, and (3) up-dip migration of the oil that accumulated under the caprock. The dependence on the reservoir parameters can be summarized by dimensionless groups. There is a dimensionless time for the vertical displacement of oil by gravity. The accumulation of a high oil saturation under the caprock is dependent on the ratio of the capillary transition zone and the sand thickness. The updip migration is dependent on a combination of the gravity number and the endpoint mobility ratio.

  9. Of Refrigerators & Regulations

    Broader source: Energy.gov [DOE]

    Editor's Note: This entry has been cross-posted from The White House Blog. The President took a moment during his speech to put the debate over regulation in a different perspective.

  10. Regulating for the long term: SMCRA and acid mine drainage

    SciTech Connect (OSTI)

    Shea, C.W.

    1995-12-31

    With the passage of the Surface Mining Control and Reclamation Act of 1977 (SMCRA), regulators and industry representatives expected to solve the problem of pollution of the Nation`s waterways caused by acidic discharges from coal mines. Eighteen years after the passage of SMCRA, hard issues of predicting, regulating and treating acid mine drainage remain. Acid mine drainage is most common in the coal seams of the Midwest and Appalachia: Pennsylvania, West Virginia, Maryland, Ohio, Illinois, and Tennessee. This article discusses regulation of coal mines and acid mine drainage for the long term.

  11. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit...

  12. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Auxin Regulation Mechanism Discovered Print Wednesday, 29 August 2007 00:00 The plant hormone auxin regulates many plant growth and development processes, including shoot growth,...

  13. Reviving regulation - and antitrust

    SciTech Connect (OSTI)

    Shepherd, W.G.

    1994-06-01

    The ills of utility regulation have been overstated by interested players and at least some academics. One can have the best features of both competition and regulation by a paradigm that combines some regulation with stronger antitrust enforcement. It is now obvious that the success of deregulation actually depends crucially on whether antitrust policy is effective in preventing monopoly. In fact, antitrust policies have been extremely weak since 1980, under a deliberate Reagan administration withdrawal of enforcement. Where deregulation has led to market dominance, which antitrust cannot well cure, the policy changes of the 1980`s may have created costly and irreversible mistakes in a number of major sectors. Yet fast-paced events are currently creating a frenzy of even more deregulation, supposedly to fit new {open_quotes}revolutions{close_quotes} in technology and the impacts of large mergers. Instead it is time for particular caution in electricity.

  14. Litigation, Regulation and Enforcement | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    General Counsel for Legislation, Regulation and Energy Efficiency (GC-33) Litigation, Regulation and Enforcement Litigation Enforcement Legislation, Regulation and Energy ...

  15. Categorical Exclusion Determinations: Natural Gas Regulation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Natural Gas Regulation Categorical Exclusion Determinations: Natural Gas Regulation Categorical Exclusion Determinations issued by Natural Gas Regulation. DOCUMENTS AVAILABLE FOR ...

  16. Acquisition Letters Remaining In Effect

    Broader source: Energy.gov [DOE]

    Acquisition Letter (AL) 2010-07 has been issued. It lists ALs currently in effect and the discontinued ALs along with the reason why the AL is no longer in effect.

  17. Acquisition Letters Remaining In Effect

    Broader source: Energy.gov [DOE]

    Acquisition Letter (AL) 2012-01 has been issued. It lists ALs currently in effect and the discontinued ALs, along with the reason why the AL is no longer in effect.

  18. Evolving Role of the Power Sector Regulator: A Clean Energy Regulators Initiative Report

    SciTech Connect (OSTI)

    Zinaman, O.; Miller, M.; Bazilian, M.

    2014-04-01

    This paper seeks to briefly characterize the evolving role of power sector regulation. Given current global dynamics, regulation of the power sector is undergoing dramatic changes. This transformation is being driven by various factors including technological advances and cost reductions in renewable energy, energy efficiency, and demand management; increasing air pollution and climate change concerns; and persistent pressure for ensuring sustainable economic development and increased access to energy services by the poor. These issues add to the already complex task of power sector regulation, of which the fundamental remit remains to objectively and transparently ensure least-cost service delivery at high quality. While no single regulatory task is trivial to undertake, it is the prioritization and harmonization of a multitude of objectives that exemplifies the essential challenge of power sector regulation. Evolving regulatory roles can be understood through the concept of existing objectives and an additional layer of emerging objectives. Following this categorization, we describe seven existing objectives of power sector regulators and nine emerging objectives, highlighting key challenges and outlining interdependencies. This essay serves as a preliminary installment in the Clean Energy Regulatory Initiative (CERI) series, and aims to lay the groundwork for subsequent reports and case studies that will explore these topics in more depth.

  19. ELECTRON EMISSION REGULATING MEANS

    DOE Patents [OSTI]

    Brenholdt, I.R.

    1957-11-19

    >An electronic regulating system is described for controlling the electron emission of a cathode, for example, the cathode in a mass spectrometer. The system incorporates a transformer having a first secondary winding for the above-mentioned cathode and a second secondary winding for the above-mentioned cathode and a second secondary winding load by grid controlled vacuum tubes. A portion of the electron current emitted by the cathode is passed through a network which develops a feedback signal. The system arrangement is completed by using the feedback signal to control the vacuum tubes in the second secondary winding through a regulator tube. When a change in cathode emission occurs, the feedback signal acts to correct this change by adjusting the load on the transformer.

  20. Interrelationship of Program Regulations and Financial Assistance Regulations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1980-04-24

    The purpose of this Order is to set forth the interrelationship between all program regulations which will result in assistance awards (Program Regulations) and the Department of Energy Assistance Regulations (DOE-AR, 10 CRF Part 600), including procedures for exceptions, deviations or waivers.

  1. Remaining Sites Verification Package for the 100-C-9:2 Sanitary Sewer Pipelines, Waste Site Reclassification Form 2004-013

    SciTech Connect (OSTI)

    L. M. Dittmer

    2007-07-11

    The 100-C-9:2 sanitary sewer pipelines include the feeder pipelines associated with the 1607-B8, the 1607-B9, the 1607-B10 and the 1607-B11 septic systems. Contaminated soil and piping from the feeder lines to the septic systems were removed and disposed of. The remaining soil in the excavations has been shown to meet the remedial action objectives specified in the Remaining Sites ROD. The results of verification sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  2. Self-regulating valve

    DOE Patents [OSTI]

    Humphreys, D.A.

    1982-07-20

    A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.

  3. Temperature controlled high voltage regulator

    DOE Patents [OSTI]

    Chiaro, Jr., Peter J. (Clinton, TN); Schulze, Gerald K. (Knoxville, TN)

    2004-04-20

    A temperature controlled high voltage regulator for automatically adjusting the high voltage applied to a radiation detector is described. The regulator is a solid state device that is independent of the attached radiation detector, enabling the regulator to be used by various models of radiation detectors, such as gas flow proportional radiation detectors.

  4. Phased Construction Completion Report for Bldg. K-1401 of the Remaining Facilities Demolition Project at the East Tennessee Technology Park, Oak Ridge, Tennessee

    SciTech Connect (OSTI)

    Bechtel Jacobs

    2008-10-01

    This Phased Construction Completion Report documents the demolition of Bldg. K-1401, Maintenance Building, addressed in the Action Memorandum for the Remaining Facilities Demolition Project at East Tennessee Technology Park, Oak Ridge, Tennessee (DOE 2003a) as a Comprehensive Environmental Response, Compensation, and Liability Act of 1980 non-time-critical removal action. The objectives of the removal action (DOE 2003a) - to eliminate the source of potential contamination, to eliminate the threat of potential future releases, and/or to eliminate the threats to the general public and the environment - were met. The end state of this action is for the slab to remain with all penetrations sealed and grouted or backfilled. The basement and pits remain open. There is residual radiological and polychlorinated biphenyl contamination on the slab and basement. A fixative was applied to the area on the pad contaminated with polychlorinated biphenyls. Interim land-use controls will be maintained until final remediation decisions are made under the Zone 2 Record of Decision (DOE 2005a).

  5. Phased Construction Completion Report for Building K-1401 of the Remaining Facilities Demolition Project at the East Tennessee Technology Park Oak Ridge, Tennessee

    SciTech Connect (OSTI)

    Garland S.

    2008-03-01

    This Phased Construction Completion Report documents the demolition of Bldg. K-1401, Maintenance Building, addressed in the Action Memorandum for the Remaining Facilities Demolition Project at East Tennessee Technology Park, Oak Ridge, Tennessee (DOE 2003a) as a Comprehensive Environmental Response, Compensation, and Liability Act of 1980 non-time-critical removal action. The objectives of the removal action (DOE 2003a) - to eliminate the source of potential contamination, to eliminate the threat of potential future releases, and/or to eliminate the threats to the general public and the environment - were met. The end state of this action is for the slab to remain with all penetrations sealed and grouted or backfilled. The basement and pits remain open. There is residual radiological and polychlorinated biphenyl contamination on the slab and basement. A fixative was applied to the area on the pad contaminated with polychlorinated biphenyls. Interim land-use controls will be maintained until final remediation decisions are made under the Zone 2 Record of Decision (DOE 2005a).

  6. Vermont Hazardous Waste Management Regulations | Open Energy...

    Open Energy Info (EERE)

    Hazardous Waste Management Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Vermont Hazardous Waste Management...

  7. Regulators, Boards, Councils - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    About Hanford Cleanup Regulators, Boards, Councils About Us About Hanford Cleanup Regulators, Boards, Councils Hanford Advisory Board Hanford Natural Resource Trustee Council Environmental Protection Agency Washington State Department of Ecology Defense Nuclear Facilities Safety Board Hanford History Hanford Site Wide Programs Contact Us Regulators, Boards, Councils Email Email Page | Print Print Page |Text Increase Font Size Decrease Font Size There are numerous entities involved in Hanford

  8. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Unique Auxin Regulation Mechanism Discovered Print Wednesday, 29 August 2007 00:00 The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction

  9. Remaining Sites Verification Package for the 100-B-1 Surface Chemical and Solid Waste Dumping Area, Waste Site Reclassification Form 2006-003

    SciTech Connect (OSTI)

    R. A. Carlson

    2006-04-24

    The 100-B-1 waste site was a dumping site that was divided into two areas. One area was used as a laydown area for construction materials, and the other area was used as a chemical dumping area. The 100-B-1 Surface Chemical and Solid Waste Dumping Area site meets the remedial action objectives specified in the Remaining Sites ROD. The results demonstrate that residual contaminant concentrations support future unrestricted land uses that can be represented by a rural-residential scenario. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  10. Collegiate Wind Competition Rules and Regulations | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Collegiate Wind Competition Rules and Regulations Collegiate Wind Competition Rules and Regulations The competition challenges interdisciplinary teams of undergraduate students ...

  11. Street sweeping and stormwater regulations

    SciTech Connect (OSTI)

    Not Available

    1993-10-01

    This article examines the role of street sweeping in meeting the requirements of the Clean Water Act stormwater regulations. The article identifies those industrial and municipal activities which are covered by the regulations and cites frequent sweeping of site surfaces for industry and street sweeping for municipalities as an integral part of compliance plans.

  12. Remaining Sites Verification Package for the 100-F-44:2, Discovery Pipeline Near 108-F Building, Waste Site Reclassification Form 2007-006

    SciTech Connect (OSTI)

    J. M. Capron

    2008-05-30

    The 100-F-44:2 waste site is a steel pipeline that was discovered in a junction box during confirmatory sampling of the 100-F-26:4 pipeline from December 2004 through January 2005. The 100-F-44:2 pipeline feeds into the 100-F-26:4 subsite vitrified clay pipe (VCP) process sewer pipeline from the 108-F Biology Laboratory at the junction box. In accordance with this evaluation, the confirmatory sampling results support a reclassification of this site to No Action. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. The results of confirmatory sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

  13. Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

    SciTech Connect (OSTI)

    Simmons, K.L.; Ramuhali, P.; Brenchley, D.L.; Coble, J.B.; Hashemian, H.M.; Konnick, R.; Ray, S.

    2012-09-01

    Executive Summary [partial] The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. A workshop was held to gather subject matter experts to develop the NDE R&D Roadmap for Cables. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, and NDE instrumentation development from the U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), universities, commercial NDE service vendors and cable manufacturers, and the Electric Power Research Institute (EPRI).

  14. Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

    SciTech Connect (OSTI)

    Simmons, Kevin L.; Ramuhalli, Pradeep; Brenchley, David L.; Coble, Jamie B.; Hashemian, Hash; Konnik, Robert; Ray, Sheila

    2012-09-14

    The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), NDE instrumentation development, universities, commercial NDE services and cable manufacturers, and Electric Power Research Institute (EPRI). The motivation for the R&D roadmap comes from the need to address the aging management of in-containment cables at nuclear power plants (NPPs).

  15. Alternative Fuels Data Center: Conversion Regulations

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    Conversion Regulations to someone by E-mail Share Alternative Fuels Data Center: Conversion Regulations on Facebook Tweet about Alternative Fuels Data Center: Conversion Regulations on Twitter Bookmark Alternative Fuels Data Center: Conversion Regulations on Google Bookmark Alternative Fuels Data Center: Conversion Regulations on Delicious Rank Alternative Fuels Data Center: Conversion Regulations on Digg Find More places to share Alternative Fuels Data Center: Conversion Regulations on

  16. APPARATUS FOR REGULATING HIGH VOLTAGE

    DOE Patents [OSTI]

    Morrison, K.G.

    1951-03-20

    This patent describes a high-voltage regulator of the r-f type wherein the modulation of the r-f voltage is accomplished at a high level, resulting in good stabilization over a large range of load conditions.

  17. Environmental Regulations | Open Energy Information

    Open Energy Info (EERE)

    Regulations Jump to: navigation, search To do: add table This article is a stub. You can help OpenEI by expanding it. Retrieved from "http:en.openei.orgwindex.php?titleEnviron...

  18. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction machinery system) was identified as a receptor for auxin. Now, an

  19. Federal Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Regulations Federal Regulations keyboard-621831_960_720.jpg Cybersecurity Atomic Energy Act of 1954 (pdf) Computer Fraud and Abuse Act of 1986 Electronic Communications Privacy Act of 1986 Federal Information Security Management Act of 2002 (Title III of E-Gov) Homeland Security Act of 2002 (includes Cyber Security Act of 2002 and Critical Infrastructure Act of 2002) Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act Cyber

  20. Federal Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Regulations Federal Regulations NOTE: Adobe Acrobat Reader may be necessary to view PDF documents listed below. Accessibility Section 508 of the Rehabilitation Act - Electronic and Information Technology Accessibility Standards Section 504 of the Rehabilitation Act - Nondiscrimination Under Federal Grants and Programs Federal Records Act Freedom of Information Act (as amended) Freedom of Information Act Updates Privacy Act of 1974 (as amended) Privacy Act Overview Cyber Security Atomic

  1. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction machinery system) was identified as a receptor for auxin. Now, an

  2. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction machinery system) was identified as a receptor for auxin. Now, an

  3. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unique Auxin Regulation Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms, and flowering. But how such a simple molecule elicits such a variety of cellular responses has been a mystery. An important breakthrough came in 2005, wh en a conserved plant protein known as TIR1 (part of a protein destruction machinery system) was identified as a receptor for auxin. Now, an

  4. The mapping and differentiation of biological and environmental elemental signatures in the fossil remains of a 50 million year old bird

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Egerton, Victoria M.; Wogelius, Roy A.; Norell, Mark A.; Edwards, Nicholas P.; Sellers, William I.; Bergmann, Uwe; Sokaras, Dimosthenis; Alonso-Mori, Roberto; Ignatyev, Konstantin; van Veelen, Arjen; et al

    2015-01-22

    The preservation of fossils reflects the interplay of inorganic and organic chemical processes, which should be clearly differentiated to make interpretations about the biology of extinct organisms. A new coliiformes bird (mouse bird) from the ~50 million year old Green River Formation (Wyoming, USA) has here been analysed using synchrotron X-ray fluorescence and environmental scanning electron microscopy with an attached X-ray energy dispersive system (ESEM-EDS). The concentration and distribution of 16 elements (Si, P, S, Cl, K, Ca, Ti, Mg, Fe, Ni, Cu, Zn, As, Br, Ba, Hg) has been mapped for individual points on the sample. S, Cu andmore » Zn map distinctly within visibly preserved feathers and X-ray Absorption Spectroscopy (XAS) shows that S and Cu within the feathers are organically bound in a similar manner to modern feathers. The morphological preservation of the feathers, on both macro- and microscopic scales, is variable throughout the fossil and the differences in the lateral microfacies have resulted in a morphological preservation gradient. This study clearly differentiates endogenous organic remains from those representing exogenous overprinted geochemical precipitates and illustrates the chemical complexity of the overall taphonomic process.« less

  5. The mapping and differentiation of biological and environmental elemental signatures in the fossil remains of a 50 million year old bird

    SciTech Connect (OSTI)

    Egerton, Victoria M.; Wogelius, Roy A.; Norell, Mark A.; Edwards, Nicholas P.; Sellers, William I.; Bergmann, Uwe; Sokaras, Dimosthenis; Alonso-Mori, Roberto; Ignatyev, Konstantin; van Veelen, Arjen; Anné, Jennifer; van Dongen, Bart; Knoll, Fabien; Manning, Phillip L.

    2015-01-22

    The preservation of fossils reflects the interplay of inorganic and organic chemical processes, which should be clearly differentiated to make interpretations about the biology of extinct organisms. A new coliiformes bird (mouse bird) from the ~50 million year old Green River Formation (Wyoming, USA) has here been analysed using synchrotron X-ray fluorescence and environmental scanning electron microscopy with an attached X-ray energy dispersive system (ESEM-EDS). The concentration and distribution of 16 elements (Si, P, S, Cl, K, Ca, Ti, Mg, Fe, Ni, Cu, Zn, As, Br, Ba, Hg) has been mapped for individual points on the sample. S, Cu and Zn map distinctly within visibly preserved feathers and X-ray Absorption Spectroscopy (XAS) shows that S and Cu within the feathers are organically bound in a similar manner to modern feathers. The morphological preservation of the feathers, on both macro- and microscopic scales, is variable throughout the fossil and the differences in the lateral microfacies have resulted in a morphological preservation gradient. This study clearly differentiates endogenous organic remains from those representing exogenous overprinted geochemical precipitates and illustrates the chemical complexity of the overall taphonomic process.

  6. Post regulation circuit with energy storage

    DOE Patents [OSTI]

    Ball, Don G.; Birx, Daniel L.; Cook, Edward G.

    1992-01-01

    A charge regulation circuit provides regulation of an unregulated voltage supply and provides energy storage. The charge regulation circuit according to the present invention provides energy storage without unnecessary dissipation of energy through a resistor as in prior art approaches.

  7. Output-Based Regulations: A Handbook for Air Regulators (U.S...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Output-Based Regulations: A Handbook for Air Regulators (U.S. EPA), August 2004 Output-Based Regulations: A Handbook for Air Regulators (U.S. EPA), August 2004 The U.S. ...

  8. Regulations, Guidelines and Codes and Standards | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Safety, Codes & Standards Current Approaches to Safety, Codes & Standards Regulations, Guidelines and Codes and Standards Regulations, Guidelines and Codes and Standards Many ...

  9. Alaska ADEC Wetlands Regulation | Open Energy Information

    Open Energy Info (EERE)

    Wetlands Regulation Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Alaska ADEC Wetlands Regulation Author Alaska Division of Water Published Alaska...

  10. Fish Habitat Regulations | Open Energy Information

    Open Energy Info (EERE)

    Fish Habitat Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Fish Habitat Regulations Author Alaska Department of Fish & Game Published...

  11. International Electricity Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation International Electricity Regulation U.S. trade in electric energy with Canada and Mexico is rising, bringing economic and reliability benefits to the United States and ...

  12. ISOs: The new antitrust regulators?

    SciTech Connect (OSTI)

    Raskin, D.B.

    1998-04-01

    Fear of seller market power in emerging electricity markets has led regulators to sanction use of independent system operators as private market police. A more restrained approach is likely to yield better results without the chilling effects of private regulation. This new industry regulatory paradigm has received little critical attention to date. This is unfortunate because ISO antitrust regulation raises serious legal and policy concerns. The California and New England Power Pool (NEPOOL) plans are quite intrusive. They require the ISO to make difficult distinctions between acceptable and unacceptable market behavior. They create considerable risk that desirable competitive behavior will be chilled and that market participants will incur significant explicit and implicit costs to meet regulatory requirements.

  13. Chapter 2 of the Wyoming Public Service Commission Regulations...

    Open Energy Info (EERE)

    2 of the Wyoming Public Service Commission Regulations: General Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation:...

  14. Frequency regulator for synchronous generators

    DOE Patents [OSTI]

    Karlicek, Robert F.

    1982-01-01

    The present invention is directed to a novel frequency regulator which controls a generator output frequency for variations in both the input power to the generator and the power supplied to an uncontrolled external load. The present invention further includes over current and current balance protection devices which are relatively inexpensive to manufacture, which may be encapsulated to provide protection from the operating environment and which respond more quickly than previously known electromechanical devices.

  15. Photomultiplier tube gain regulating system

    DOE Patents [OSTI]

    Johnson, Wayne F.

    1976-01-01

    This invention relates to an improved system for regulating the gain of a photomultiplier tube, and was designed for use with the photomultiplier tubes of a GeMSAEC fast analyzers. It has the following advantages over the prior system: noise is virtually eliminated; sample analysis can begin after 3 to 4 revolutions of the rotor; fluorescent and light scattering solutions can be used as a reference; and the reference solution can be in any cuvette on the rotor.

  16. GP-8 LAWS AND REGULATIONS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    40-DOP (5-2011) Supersedes (7-2010) issue DECLARATION of OCCUPATIONAL MEDICINE PROVIDER GENERAL INFORMATION PURPOSE All Contractors and their lower-tier subcontractors must comply with the Department of Energy's Worker Safety and Health Program regulation, 10 CFR 851, "Worker Safety and Health Program (WSHP). The WSHP enforces worker safety and health requirements including, but not limited to, standards of the Occupational Safety and Health Administration (OSHA), American National

  17. Frequency regulator for synchronous generators

    DOE Patents [OSTI]

    Karlicek, R.F.

    1982-08-10

    The present invention is directed to a novel frequency regulator which controls a generator output frequency for variations in both the input power to the generator and the power supplied to an uncontrolled external load. The present invention further includes over current and current balance protection devices which are relatively inexpensive to manufacture, which may be encapsulated to provide protection from the operating environment and which respond more quickly than previously known electromechanical devices. 11 figs.

  18. NRC - regulator of nuclear safety

    SciTech Connect (OSTI)

    1997-05-01

    The U.S. Nuclear Regulatory Commission (NRC) was formed in 1975 to regulate the various commercial and institutional uses of nuclear energy, including nuclear power plants. The agency succeeded the Atomic Energy Commission, which previously had responsibility for both developing and regulating nuclear activities. Federal research and development work for all energy sources, as well as nuclear weapons production, is now conducted by the U.S. Department of Energy. Under its responsibility to protect public health and safety, the NRC has three principal regulatory functions: (1) establish standards and regulations, (2) issue licenses for nuclear facilities and users of nuclear materials, and (3) inspect facilities and users of nuclear materials to ensure compliance with the requirements. These regulatory functions relate to both nuclear power plants and to other uses of nuclear materials - like nuclear medicine programs at hospitals, academic activities at educational institutions, research work, and such industrial applications as gauges and testing equipment. The NRC places a high priority on keeping the public informed of its work. The agency recognizes the interest of citizens in what it does through such activities as maintaining public document rooms across the country and holding public hearings, public meetings in local areas, and discussions with individuals and organizations.

  19. Output-Based Regulations: A Handbook for Air Regulators (U.S. EPA), August 2004

    Broader source: Energy.gov [DOE]

    Handbook providing practical information to help regulators decide if they want to use output-based regulations and explains how to develop an output-based emission standard

  20. Colorado Code of Regulations 4 CCR 723-3, Rules Regulating Electric...

    Open Energy Info (EERE)

    Colorado Code of Regulations 4 CCR 723-3, Rules Regulating Electric Utilities Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  1. Code of Colorado Regulations 4 CCR 723-3, Rules Regulating Electric...

    Open Energy Info (EERE)

    Code of Colorado Regulations 4 CCR 723-3, Rules Regulating Electric Utilities Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  2. Surface mine regulations complicate reclamation

    SciTech Connect (OSTI)

    Seltz-Patrash, A.

    1980-09-01

    The Surface Mining Control and Reclamation Act of 1977 is a landmark environmental law intended to protect U.S. lands from stripmining effects. However, coal mine operators claim that some SMCRA regulations are misguidedcosting time and money, but yielding no substantial environmental benefit. Unlike other environmental acts, SMCRA details specifically the goals of reclamation and the methods that must be implemented to meet these goals. Coal industry representatives believe that this discourages innovation, promotes inefficiency by ignoring regional differences among sites, and results in unnecessary expense to the industry. Reclamation practices and progress among western coal mining companies are evaluated. (1 map, 5 photos)

  3. Clean Water Act and Regulations (EPA)

    Broader source: Energy.gov [DOE]

    The Clean Water Act (CWA; 33 U.S.C. §1251 et seq.) establishes the basic structure for regulating discharges of pollutants into the waters of the United States and regulating quality standards for surface waters.

  4. Investment and regulation: the Dutch experience

    SciTech Connect (OSTI)

    Haffner, Robert; Helmer, Dorine; van Til, Harry

    2010-06-15

    Theoretical studies on the relationship between incentive regulation and investment in network industries generally point out that incentive regulation has a negative impact on investment. However, empirical evidence in this area is scarce. An analysis suggests that in the Dutch electricity and gas networks since 2001, incentive regulation has ensured a more rational and professional approach towards investments, with investment levels coming down somewhat at the start of the regulation but picking up later on. (author)

  5. certification, compliance and enforcement regulations for Commercial...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PDF icon certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) More Documents & Publications Regulatory Burden RFI Executive Order ...

  6. Regulations for beneficial use changing nationwide

    SciTech Connect (OSTI)

    Goss, D.

    2008-07-01

    Regulations on the use of coal combustion products (CCPs) that are being considered by various US states are reviewed.

  7. Environmental Laws and Regulations | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Record Files Natural Resource Damage Assessments Environmental Laws and Regulations More Documents & Publications Paducah Public Involvement Plan Portsmouth Removal Actions...

  8. certification, compliance and enforcement regulations for Commercial

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Refrigeration Equipment (CRE) | Department of Energy certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) The current certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) "simply makes no sense". The regulations define the basic model as any product that has a different energy use or efficiency

  9. Geothermal developers remain optimistic | Department of Energy

    Energy Savers [EERE]

    and shrinks capital available for renewable energy projects of all types, the outlook for ... or Wilderness Study Areas because these areas are off-limits to new leasing by law. ...

  10. Remaining Barriers to LED Street Lighting

    Energy Savers [EERE]

    ownership, involving multiple decision-makers * Utilities own 60-70% of street lighting inventory in U.S. * Sometimes more than one utility present in a given metro area * Often...

  11. Staff Listing - Office of Regulation and International Engagement, Division

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Natural Gas Regulation, Division of International Engagement | Department of Energy Staff Listing - Office of Regulation and International Engagement, Division of Natural Gas Regulation, Division of International Engagement Staff Listing - Office of Regulation and International Engagement, Division of Natural Gas Regulation, Division of International Engagement Office of Regulation and International Engagement Mailing Address: Office of Regulation and International Engagement Office of

  12. 18 CFR 380 Regulations Implementing the National Environmental...

    Open Energy Info (EERE)

    380 Regulations Implementing the National Environmental Policy Act Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 18 CFR...

  13. Chapter 9 of the Wyoming Public Service Commission Regulations...

    Open Energy Info (EERE)

    9 of the Wyoming Public Service Commission Regulations: General Forms Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation:...

  14. Key Publications - Natural Gas Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Services Natural Gas Regulation Key Publications - Natural Gas Regulation Key Publications - Natural Gas Regulation Natural Gas Imports and Exports - Quarterly Reports May ...

  15. Title 27 California Code of Regulations: Environmental Protection...

    Open Energy Info (EERE)

    7 California Code of Regulations: Environmental Protection Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Title 27...

  16. Staff Listing - Office of Regulation and International Engagement...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Staff Listing - Office of Regulation and International Engagement, Division of Natural Gas Regulation, Division of International Engagement Staff Listing - Office of Regulation and ...

  17. Rules and Regulations of the Wyoming Industrial Siting Council...

    Open Energy Info (EERE)

    Document- RegulationRegulation: Rules and Regulations of the Wyoming Industrial Siting Council - Chapter 1Legal Abstract Industrial development information and siting rules and...

  18. Advisory Council on Historic Preservation - Section 106 Regulations...

    Open Energy Info (EERE)

    OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Advisory Council on Historic Preservation - Section 106 RegulationsLegal Abstract Section 106 requires...

  19. Rules and Regulations of the Wyoming Industrial Siting Council...

    Open Energy Info (EERE)

    Document- RegulationRegulation: Rules and Regulations of the Wyoming Industrial Siting Council - Chapter 2Legal Abstract Rules of practice and proceedures of the Industrial Siting...

  20. Rules and Regulations of the Industrial Siting Council, Chapter...

    Open Energy Info (EERE)

    Industrial Siting Council, Chapter 1 Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Rules and Regulations of the...

  1. WAC - 173-303 Dangerous Waste Regulations | Open Energy Information

    Open Energy Info (EERE)

    03 Dangerous Waste Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC - 173-303 Dangerous Waste...

  2. 2011 Air Quality Regulations Report | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Air Quality Regulations Report 2011 Air Quality Regulations Report PDF icon 2011 Air Quality Regulations Report120111.pdf More Documents & Publications 2011:...

  3. 2011: Air Quality Regulations Report | Department of Energy

    Office of Environmental Management (EM)

    : Air Quality Regulations Report 2011: Air Quality Regulations Report PDF icon 2011 Air Quality Regulations ReportA120911.pdf More Documents & Publications 2011...

  4. Regulations for Implementing the Procedural Provisions of NEPA...

    Energy Savers [EERE]

    Regulations for Implementing the Procedural Provisions of NEPA Regulations for Implementing the Procedural Provisions of NEPA PDF icon CEQ Regulations for Implementing the...

  5. Quantifying and Generalizing Hydrologic Responses to Dam Regulation using a Statistical Modeling Approach

    SciTech Connect (OSTI)

    McManamay, Ryan A

    2014-01-01

    Despite the ubiquitous existence of dams within riverscapes, much of our knowledge about dams and their environmental effects remains context-specific. Hydrology, more than any other environmental variable, has been studied in great detail with regard to dam regulation. While much progress has been made in generalizing the hydrologic effects of regulation by large dams, many aspects of hydrology show site-specific fidelity to dam operations, small dams (including diversions), and regional hydrologic regimes. A statistical modeling framework is presented to quantify and generalize hydrologic responses to varying degrees of dam regulation. Specifically, the objectives were to 1) compare the effects of local versus cumulative dam regulation, 2) determine the importance of different regional hydrologic regimes in influencing hydrologic responses to dams, and 3) evaluate how different regulation contexts lead to error in predicting hydrologic responses to dams. Overall, model performance was poor in quantifying the magnitude of hydrologic responses, but performance was sufficient in classifying hydrologic responses as negative or positive. Responses of some hydrologic indices to dam regulation were highly dependent upon hydrologic class membership and the purpose of the dam. The opposing coefficients between local and cumulative-dam predictors suggested that hydrologic responses to cumulative dam regulation are complex, and predicting the hydrology downstream of individual dams, as opposed to multiple dams, may be more easy accomplished using statistical approaches. Results also suggested that particular contexts, including multipurpose dams, high cumulative regulation by multiple dams, diversions, close proximity to dams, and certain hydrologic classes are all sources of increased error when predicting hydrologic responses to dams. Statistical models, such as the ones presented herein, show promise in their ability to model the effects of dam regulation effects at large spatial scales as to generalize the directionality of hydrologic responses.

  6. EPA Regulation Compliance | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EPA Regulation Compliance EPA Regulation Compliance OE offers technical assistance on implementing the new and pending EPA air rules affecting the electric utility industry. Examples of typical assistance include technical information on cost and performance of the various power plant pollution retrofit control technologies; technical information on generation, demand-side or transmission alternatives for any replacement power needed for retiring generating units; and assistance to regulators

  7. Small Self-Regulating Fission Reactor System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    359 This document is approved for public release; further dissemination unlimited Small Self-Regulating Fission Reactor System ANTICIPATED IMPACT PATH FORWARD DESCRIPTION BACKGROUND & MOTIVATION INNOVATION A power system for special government applications Point of Contact: Patrick McClure, NEN-5, pmcclure@lanl.gov (505)667-9534 Small Self-Regulating Fission Reactor System A small self- regulating fission reactor made with U 235 . LANL and NASA with the support of NSTec performed a proof of

  8. WYDOT - Utility Accommodation Regulation Manual | Open Energy...

    Open Energy Info (EERE)

    Regulation ManualPermittingRegulatory GuidanceGuideHandbook Abstract This manual sets forth the processes and procedures for utility accommodation on WYDOT rights-of-way. Author...

  9. Council on Environmental Quality - Regulations for Implementing...

    Open Energy Info (EERE)

    Implementing the Procedural Provisions of the NEPALegal Abstract These regulations set forth the processes and procedures of the National Environmental Policy Act. Published NA...

  10. Exporting licensing regulations affecting US geothermal firms

    SciTech Connect (OSTI)

    Not Available

    1988-08-01

    This document presents a brief introduction and overview of the Department of Commerce's Export Administration Regulations which might affect potential US geothermal goods exporters. It is intended to make US geothermal firms officials aware of the existence of such regulations and to provide them with references, contacts and phone numbers where they can obtain specific and detailed information and assistance. It must be stressed however, that the ultimate responsibility for complying with the above mentioned regulations lies with the exporter who must consult the complete version of the regulations.

  11. ACHP - Section 106 Regulations Flowchart Explanatory Material...

    Open Energy Info (EERE)

    Explanatory Material Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: ACHP - Section 106 Regulations Flowchart Explanatory Material Abstract This...

  12. EPA Regulations Overview Website | Open Energy Information

    Open Energy Info (EERE)

    Overview Website Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: EPA Regulations Overview Website Abstract This website contains information about...

  13. Alaska Special Area Regulations | Open Energy Information

    Open Energy Info (EERE)

    to library Web Site: Alaska Special Area Regulations Author Alaska Department of Fish & Game Published Publisher Not Provided, 2014 DOI Not Provided Check for DOI...

  14. Texas Railroad Commission - Pollution Discharge Regulations ...

    Open Energy Info (EERE)

    Not Provided DOI Not Provided Check for DOI availability: http:crossref.org Online Internet link for Texas Railroad Commission - Pollution Discharge Regulations Citation...

  15. Controlling Wind Turbines for Secondary Frequency Regulation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Controlling Wind Turbines for Secondary Frequency Regulation: An Analysis of AGC ... Workshop on Large-Scale Integration of Wind Power Into Power Systems as Well as on ...

  16. 5 CCR 1002-62 Colorado Regulations for Effluent Limitations ...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 5 CCR 1002-62 Colorado Regulations for Effluent LimitationsLegal Abstract Regulations...

  17. UAC R307 - Air Quality Regulations | Open Energy Information

    Open Energy Info (EERE)

    07 - Air Quality Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: UAC R307 - Air Quality RegulationsLegal...

  18. Rainwater harvesting state regulations and technical resources

    SciTech Connect (OSTI)

    Loper, Susan A.

    2015-06-01

    Pacific Northwest National Laboratory (PNNL) conducted in-depth research of state-level rainwater harvesting regulations for the Federal Energy Management Program (FEMP) to help federal agencies strategically identify locations conducive to rainwater harvesting projects. Currently, rainwater harvesting is not regulated by the federal government but rather it is up to individual states to regulate the collection and use of rainwater. There is no centralized information on state-level regulations on rainwater harvesting maintained by a federal agency or outside organization. To fill this information gap, PNNL performed detailed internet searches for each state, which included state agencies, universities, Cooperative Extension Offices, city governments, and related organizations. The state-by-state information on rainwater harvesting regulations was compiled and assembled into an interactive map that is color coded by state regulations. The map provides a visual representation of the general types of rainwater harvesting policies across the country as well as general information on the state programs if applicable. The map allows the user to quickly discern where rainwater harvesting is supported and regulated by the state. This map will be available on the FEMP website by September 2015.

  19. Searchable Electronic Department of Energy Acquisition Regulation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PDF icon EDEAR July 2 2013 final.pdf More Documents & Publications Microsoft Word - PART 970.doc Department of Energy Acquisition Regulation (DEAR) Final Rule for Subchapters A, B, ...

  20. Regulation of geothermal energy development in Colorado

    SciTech Connect (OSTI)

    Coe, B.A.; Forman, N.A.

    1980-01-01

    The regulatory system is presented in a format to help guide geothermal energy development. State, local, and federal agencies, legislation, and regulations are presented. Information sources are listed. (MHR)

  1. Policy, Regulation, and Codes Technical Assistance

    Broader source: Energy.gov [DOE]

    Policy, regulation, and codes technical assistance includes information and guidance for Indian tribes and Alaska Native villages on energy governance issues. Below is a list of the various options for this type of technical assistance.

  2. Exceptions to DOE Rules and Regulations

    Broader source: Energy.gov [DOE]

    The Department of Energy (DOE) issues test procedures and regulations covering a number of products, but does provide for exceptions to these rules under certain circumstances. Any person, as...

  3. Statutes, Regulations, and Directives for Classification Program |

    Energy Savers [EERE]

    Department of Energy Statutes, Regulations, and Directives for Classification Program Statutes, Regulations, and Directives for Classification Program Classification Atomic Energy Act of 1954 - Establishes Government-wide policies for classifying, safeguarding, and declassifying Restricted Data information. 10 CFR Part 1045, Nuclear Classification and Declassification - Establishes the Government-wide policies and procedures for implementing sections 141 and 142 of the Atomic Energy Act of

  4. Department of Energy Acquisition Regulation (DEAR)

    Broader source: Energy.gov [DOE]

    To ensure that you are using the most recent version of the Department of Energy Acquisition Regulation (DEAR), use one of the electronic versions at one of the following websites: DOE Procurement - http://management.energy.gov/DEAR.htm; Electronic Code of Federal Regulations - http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?c=ecfr&tpl=/ecfrbrowse/Tit... or Hill Air Force Base - http://farsite.hill.af.mil/vfdoea.htm.

  5. International Electricity Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation International Electricity Regulation U.S. trade in electric energy with Canada and Mexico is rising, bringing economic and reliability benefits to the United States and its trading partners. Within the Office of Electricity Delivery & Energy Reliability, the Permitting, Siting and Analysis Division is responsible for authorizing exports of electric energy and issuing Presidential permits for the construction, operation, maintenance and connection of electric transmission

  6. Searchable Electronic Department of Energy Acquisition Regulation |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Searchable Electronic Department of Energy Acquisition Regulation Searchable Electronic Department of Energy Acquisition Regulation Updated July 2, 2013. The EDEAR is current through the Final Rule published May 3, 2013 at 78 FR 25817 If you have any questions concerning this page, please contact Barbara Binney in the Contract and Financial Assistance Policy Division, Office of Acquisition and Project Management. PDF icon EDEAR July 2 2013 final.pdf More Documents &

  7. EVALUATION OF ACTIVATION PRODUCTS IN REMAINING IN REMAINING K-, L- AND C-REACTOR STRUCTURES

    SciTech Connect (OSTI)

    Vinson, D.; Webb, R.

    2010-09-30

    An analytic model and calculational methodology was previously developed for P-reactor and R-reactor to quantify the radioisotopes present in Savannah River Site (SRS) reactor tanks and the surrounding structural materials as a result of neutron activation of the materials during reactor operation. That methodology has been extended to K-reactor, L-reactor, and C-reactor. The analysis was performed to provide a best-estimate source term input to the Performance Assessment for an in-situ disposition strategy by Site Decommissioning and Demolition (SDD). The reactor structure model developed earlier for the P-reactor and R-reactor analyses was also used for the K-reactor and L-reactor. The model was suitably modified to handle the larger Creactor tank and associated structures. For all reactors, the structure model consisted of 3 annular zones, homogenized by the amount of structural materials in the zone, and 5 horizontal layers. The curie content on an individual radioisotope basis and total basis for each of the regions was determined. A summary of these results are provided herein. The efficacy of this methodology to accurately predict the radioisotopic content of the reactor systems in question has been demonstrated and is documented in Reference 1. As noted in that report, results for one reactor facility cannot be directly extrapolated to other SRS reactors.

  8. No Sunset and Extended Policies Cases (released in AEO2010)

    Reports and Publications (EIA)

    2010-01-01

    The Annual Energy Outlook 2010 Reference case is best described as a current laws and regulations case, because it generally assumes that existing laws and fully promulgated regulations will remain unchanged throughout the projection period, unless the legislation establishing them specifically calls for them to end or change. The Reference case often serves as a starting point for the analysis of proposed legislative or regulatory changes, a task that would be difficult if the Reference case included projected legislative or regulatory changes.

  9. REGULATIONS ON PHOTOVOLTAIC MODULE DISPOSAL AND RECYCLING.

    SciTech Connect (OSTI)

    FTHENAKIS,V.

    2001-01-29

    Environmental regulations can have a significant impact on product use, disposal, and recycling. This report summarizes the basic aspects of current federal, state and international regulations which apply to end-of-life photovoltaic (PV) modules and PV manufacturing scrap destined for disposal or recycling. It also discusses proposed regulations for electronics that may set the ground of what is to be expected in this area in the near future. In the US, several states have started programs to support the recycling of electronic equipment, and materials destined for recycling often are excepted from solid waste regulations during the collection, transfer, storage and processing stages. California regulations are described separately because they are different from those of most other states. International agreements on the movement of waste between different countries may pose barriers to cross-border shipments. Currently waste moves freely among country members of the Organization of Economic Cooperation and Development (OECD), and between the US and the four countries with which the US has bilateral agreements. However, it is expected, that the US will adopt the rules of the Basel Convention (an agreement which currently applies to 128 countries but not the US) and that the Convection's waste classification system will influence the current OECD waste-handling system. Some countries adopting the Basel Convention consider end-of-life electronics to be hazardous waste, whereas the OECD countries consider them to be non-hazardous. Also, waste management regulations potentially affecting electronics in Germany and Japan are mentioned in this report.

  10. Smart Grid Newsletter ? The Regulators Role in Grid Modernization...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Title: "The Regulator's Role in Grid Modernization" Sponsor: The Modern Grid Strategy is a DOE-funded project conducted by the National Energy Technology Laboratory Leadership from...

  11. Form:Federal Oil and Gas Regulation | Open Energy Information

    Open Energy Info (EERE)

    Federal Oil and Gas Regulation Jump to: navigation, search Federal Oil and Gas Regulation This is the "Federal Oil and Gas Regulation" form. To create a page with this form, enter...

  12. Title 48 CFR 1 Federal Acquisition Regulations System | Open...

    Open Energy Info (EERE)

    8 CFR 1 Federal Acquisition Regulations System Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- Federal RegulationFederal Regulation: Title 48 CFR...

  13. WAC - 173-360 Underground Storage Tank Regulations | Open Energy...

    Open Energy Info (EERE)

    60 Underground Storage Tank Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC - 173-360 Underground Storage...

  14. Rules and Regulations of the Board of Land Commissioners, Chapter...

    Open Energy Info (EERE)

    Board of Land Commissioners, Chapter 3 - Easements Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Rules and Regulations of...

  15. WAC 173-400 - General Regulations for Air Pollution Sources ...

    Open Energy Info (EERE)

    400 - General Regulations for Air Pollution Sources Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC 173-400 - General...

  16. WAC - 173-400 General Regulations for Air Pollution Sources ...

    Open Energy Info (EERE)

    400 General Regulations for Air Pollution Sources Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC - 173-400 General...

  17. Category:Federal Oil and Gas Regulations | Open Energy Information

    Open Energy Info (EERE)

    Regulations Jump to: navigation, search Add a new Federal Oil and Gas Regulation This category currently contains no pages or media. Retrieved from "http:en.openei.orgw...

  18. Idaho IS 61 Public Utility Regulation | Open Energy Information

    Open Energy Info (EERE)

    Regulation (2013). Retrieved from "http:en.openei.orgwindex.php?titleIdahoIS61PublicUtilityRegulation&oldid722586" Feedback Contact needs updating Image needs...

  19. Regulation Indentifier Number Title/Subject/Purpose Rule Type

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1991-AB73 Property Management Regulation: Update and eliminate inconsistencies and redundancies in DOE's personal property management regulations at 41 CFR 109. NOPR Drafting 1991...

  20. 5 CCR 1002-61 Colorado Discharge Permit System Regulations |...

    Open Energy Info (EERE)

    Discharge Permit System RegulationsLegal Abstract Regulations implementing the Colorado Water Quality Control Act applying to all operations discharging to waters of the state...

  1. SERN Policy and Regulation Database | Open Energy Information

    Open Energy Info (EERE)

    SERN Policy and Regulation Database Jump to: navigation, search Tool Summary Name: SERN Policy and Regulation Database AgencyCompany Organization: Renewable Energy and Energy...

  2. California Regulations on Renewble Hydrogen and Low Carbon Technologie...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations on Renewble Hydrogen and Low Carbon Technologies California Regulations on ... Transportation and Stationary Power Integration Workshop: A California Perspective Vision ...

  3. EO 13211: Regulations That Significantly Affect Energy Supply...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EO 13211: Regulations That Significantly Affect Energy Supply, Distribution, or Use EO 13211: Regulations That Significantly Affect Energy Supply, Distribution, or Use I am...

  4. Class Deviation from the Federal Acquisition Regulation (FAR...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation (FAR) 13.5, Test Program for Certain Commercial Items Class Deviation from the Federal Acquisition Regulation (FAR) 13.5, Test Program for Certain Commercial ...

  5. Memorandum: Participation of the EM SSAB, Stakeholders, and Regulators...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Participation of the EM SSAB, Stakeholders, and Regulators in EM Budget Requests Memorandum: Participation of the EM SSAB, Stakeholders, and Regulators in EM Budget Requests From: ...

  6. SUMMARY OF REGULATIONS IMPLEMENTING FEDERAL POWER ACT SECTION...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    SUMMARY OF REGULATIONS IMPLEMENTING FEDERAL POWER ACT SECTION 216 SUMMARY OF REGULATIONS IMPLEMENTING FEDERAL POWER ACT SECTION 216 The Energy Policy Act of 2005 added section ...

  7. New Mexico Public Regulation Commission | Open Energy Information

    Open Energy Info (EERE)

    Public Regulation Commission Name: New Mexico Public Regulation Commission Address: 33 Plaza La Prensa Place: Santa Fe, New Mexico Zip: 87507 Website: www.nmprc.state.nm.us...

  8. Natural Gas Regulation - Other Gas-Related Information Sources...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Natural Gas Regulation - Other Gas-Related Information Sources Natural Gas Regulation - Other Gas-Related Information Sources The single largest source of energy information...

  9. Sandia Energy - Self-Regulated Fabrication of Size-Controlled...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Self-Regulated Fabrication of Size-Controlled Quantum Nanostructures Home Highlights - Energy Research Self-Regulated Fabrication of Size-Controlled Quantum Nanostructures Previous...

  10. Building Codes and Regulations for Solar Water Heating Systems...

    Office of Environmental Management (EM)

    Building Codes and Regulations for Solar Water Heating Systems Building Codes and Regulations for Solar Water Heating Systems June 24, 2012 - 1:50pm Addthis Photo Credit:...

  11. Update on Diesel Exhaust Emission Control Technology and Regulations...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Control Technology and Regulations Update on Diesel Exhaust Emission Control Technology and Regulations 2004 Diesel Engine Emissions Reduction (DEER) Conference Presentation: ...

  12. Notification of Regulated Waste Activity | Open Energy Information

    Open Energy Info (EERE)

    Notification of Regulated Waste Activity Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: Notification of Regulated Waste...

  13. Guide to Federal Regulation of Sales of Imported Electricity...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the ...

  14. June 24 Webinar Will Discuss How Environmental Laws and Regulations...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Will Discuss How Environmental Laws and Regulations Affect Tribal Energy Projects June 24 Webinar Will Discuss How Environmental Laws and Regulations Affect Tribal Energy...

  15. Renewable Energy Terms of Reference: Laws, Policies and Regulations...

    Open Energy Info (EERE)

    Laws, Policies and Regulations Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Renewable Energy Terms of Reference: Laws, Policies and Regulations AgencyCompany...

  16. Federal Register Notices for DOE NEPA Guidelines and Regulations...

    Office of Environmental Management (EM)

    Notices for DOE NEPA Guidelines and Regulations Federal Register Notices for DOE NEPA Guidelines and Regulations Historical compilation of Federal Register notices for DOE NEPA...

  17. Historical impacts of environmental regulation of silver

    SciTech Connect (OSTI)

    Purcell, T.W.; Peters, J.J.

    1999-01-01

    Exposure to silver, and hence its possible environmental effects, has been regulated since the 1960s. Rules were first developed in the United States to protect against potential negative effects to humans due to ingestion of drinking water containing silver. As regulations for other environmental media were developed, silver was generally included because of its designation as a drinking water chemical of concern. Ambient water quality criteria were developed based on the toxic action of ionic silver. In the early 1990s the US Environmental Protection Agency`s Office of Drinking Water downgraded silver from a primary to a secondary maximum contaminant level because the effects of exposure to silver were judged to be cosmetic. Regulations pertaining to solid waste, surface waters, and occupational exposure have not been changed, but may be changed in the near future as the fate and toxic mechanisms of silver become better understood.

  18. Coal mining and the environment: Does SMCRA give regulators appropriate enforcement tools?

    SciTech Connect (OSTI)

    Shea, C.W.

    1994-12-31

    The Surface Mining Control and Reclamation Act of 1977 (SMCRA), 30 U.S.C. 1201 et seq (1990), reshaped the regulation of coal mining and affored government regulators a comprehensive set of enforcement tools. Major controveries remain, such as the definitions haping the Application Violator System, and the extent of federal authority to oversee the states` primary enforcement responsibility. Despite these contentious issues the federal and state programs have fundamentally succeeded in enforcing SMCRA and have successfully altered the landscape of coal mining. The structure of SMCRA`s enforcement provisions is a critical factor in this success. The article discusses in more detain the following areas: the core of SMCRA: permits and Bonds; Maintaining Standards: inspections and sanction for noncompliance; the applicant violator system; other enforcement tools.

  19. Environmental regulations handbook for enhanced oil recovery

    SciTech Connect (OSTI)

    Madden, M.P. ); Blatchford, R.P.; Spears, R.B. )

    1991-12-01

    This handbook is intended to assist owners and operators of enhanced oil recovery (EOR) operations in acquiring some introductory knowledge of the various state agencies, the US Environmental Protection Agency, and the many environmental laws, rules and regulations which can have jurisdiction over their permitting and compliance activities. It is a compendium of summarizations of environmental rules. It is not intended to give readers specific working details of what is required from them, nor can it be used in that manner. Readers of this handbook are encouraged to contact environmental control offices nearest to locations of interest for current regulations affecting them.

  20. Cell shape regulates global histone acetylation in human mammaryepithelial cells

    SciTech Connect (OSTI)

    Le Beyec, Johanne; Xu, Ren; Lee, Sun-Young; Nelson, Celeste M.; Rizki, Aylin; Alcaraz, Jordi; Bissell, Mina J.

    2007-02-28

    Extracellular matrix (ECM) regulates cell morphology and gene expression in vivo; these relationships are maintained in three-dimensional (3D) cultures of mammary epithelial cells. In the presence of laminin-rich ECM (lrECM), mammary epithelial cells round up and undergo global histone deacetylation, a process critical for their functional differentiation. However, it remains unclear whether lrECM-dependent cell rounding and global histone deacetylation are indeed part of a common physical-biochemical pathway. Using 3D cultures as well as nonadhesive and micropatterned substrata, here we showed that the cell 'rounding' caused by lrECM was sufficient to induce deacetylation of histones H3 and H4 in the absence of biochemical cues. Microarray and confocal analysis demonstrated that this deacetylation in 3D culture is associated with a global increase in chromatin condensation and a reduction in gene expression. Whereas cells cultured on plastic substrata formed prominent stress fibers, cells grown in 3D lrECM or on micropatterns lacked these structures. Disruption of the actin cytoskeleton with cytochalasin D phenocopied the lrECM-induced cell rounding and histone deacetylation. These results reveal a novel link between ECM-controlled cell shape and chromatin structure, and suggest that this link is mediated by changes in the actin cytoskeleton.

  1. Coping with uncertainties of mercury regulation

    SciTech Connect (OSTI)

    Reich, K.

    2006-09-15

    The thermometer is rising as coal-fired plants cope with the uncertainties of mercury regulation. The paper deals with a diagnosis and a suggested cure. It describes the state of mercury emission rules in the different US states, many of which had laws or rules in place before the Clean Air Mercury Rule (CAMR) was promulgated.

  2. Src regulates the activity of SIRT2

    SciTech Connect (OSTI)

    Choi, You Hee; Kim, Hangun; Lee, Sung Ho; Jin, Yun-Hye; Lee, Kwang Youl

    2014-07-25

    Highlights: Src decreases the protein levels of Sirt2. Src inhibitor and knockdown of Src increase the protein levels of Sirt2. Src interacts with and phosphorylates Sirt2. Src regulate the activity of Sirt2. - Abstract: SIRT2 is a mammalian member of the Sirtuin family of NAD{sup +}-dependent protein deacetylases. The tyrosine kinase Src is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganization. The function of SIRT2 is modulated by post-translational modifications; however, the precise molecular signaling mechanism of SIRT2 through interactions with c-Src has not yet been established. In this study, we investigated the potential regulation of SIRT2 function by c-Src. We found that the protein levels of SIRT2 were decreased by c-Src, and subsequently rescued by the addition of a Src specific inhibitor, SU6656, or by siRNA-mediated knockdown of c-Src. The c-Src interacts with and phosphorylates SIRT2 at Tyr104. c-Src also showed the ability to regulate the deacetylation activity of SIRT2. Investigation on the phosphorylation of SIRT2 suggested that this was the method of c-Src-mediated SIRT2 regulation.

  3. State-federal interactions in nuclear regulation

    SciTech Connect (OSTI)

    Pasternak, A.D.; Budnitz, R.J.

    1987-12-01

    The Atomic Energy Act of 1954 established, and later Congressional amendments have confirmed, that except in areas which have been explicitly granted to the states, the federal government possesses preemptive authority to regulate radiation hazards associated with the development and use of atomic energy. Since the passage of the original Act, numerous decisions by the courts have reaffirmed the legitimacy of federal preemption, and have defined and redefined its scope. In this study, the aim is to explore the underlying issues involved in federal preemption of radiation-hazard regulation, and to recommend actions that the Department of Energy and other agencies and groups should consider undertaking in the near term to protect the preemption principle. Appropriate roles of the states are discussed, as well as recent state-level activities and their rationale, and several current arenas in which state-federal conflicts about regulation of hazards are being played out. The emphasis here is on four particular arenas that are now important arenas of conflict, but the issues discussed are far broader in scope. These four arenas are: state-level moratorium activity; emergency planning for reactors; conflicts arising from state financial regulation; and inroads in federal preemption through litigation under state law.

  4. Method for regulation of plant lignin composition

    DOE Patents [OSTI]

    Chapple, Clint (West Lafayette, IN)

    1999-01-01

    A method is disclosed for the regulation of lignin composition in plant tissue. Plants are transformed with a gene encoding an active F5H gene. The expression of the F5H gene results in increased levels of syringyl monomer providing a lignin composition more easily degraded with chemicals and enzymes.

  5. Voltage regulation in linear induction accelerators

    DOE Patents [OSTI]

    Parsons, William M.

    1992-01-01

    Improvement in voltage regulation in a Linear Induction Accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance.

  6. Voltage regulation in linear induction accelerators

    DOE Patents [OSTI]

    Parsons, W.M.

    1992-12-29

    Improvement in voltage regulation in a linear induction accelerator wherein a varistor, such as a metal oxide varistor, is placed in parallel with the beam accelerating cavity and the magnetic core is disclosed. The non-linear properties of the varistor result in a more stable voltage across the beam accelerating cavity than with a conventional compensating resistance. 4 figs.

  7. 49 CFR Parts 171-177: Hazardous Materials Regulations (DOT)

    Broader source: Energy.gov [DOE]

    The U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration regulates the transport of hazardous materials through Title 49 of the Code of Federal Regulations (49 CFR), Subchapter C, "Hazardous Materials Regulations." Parts 171-177 provide general information on hazardous materials and regulation for their packaging and their shipment by rail, air, vessel, and public highway.

  8. Federal Regulations | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Federal Regulations Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review Boards (IRBs) Education and Resources Regulations and Requirements Ethical Principles Federal Regulations DOE Special Requirements Health Insurance Portability and Accountability Act (HIPAA) Glossary Abbreviations Contact BER Home Contact Information Human Subjects Protection Program U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 Regulations and

  9. Collegiate Wind Competition 2014 Rules and Regulations | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy 2014 Rules and Regulations Collegiate Wind Competition 2014 Rules and Regulations This document outlines the rules and regulations for the inaugural Collegiate Wind Competition in 2014. PDF icon U.S. Department of Energy Collegiate Wind Competition 2014 Rules and Regulations More Documents & Publications Collegiate Wind Competition Rules and Regulations Team roster: Andrew Dallas, Aerospace Engineering; Mario Mondal, Aerospace Engineering; Atif Salahudeen, Aerospace Engineering;

  10. Notice of 2009 Guidance on Energy Efficiency Enforcement Regulations |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 2009 Guidance on Energy Efficiency Enforcement Regulations Notice of 2009 Guidance on Energy Efficiency Enforcement Regulations Notice - DOE Guidance on Energy Efficiency Enforcement Regulations, Federal Register Vol. 74, No. 197 October 14, 2009. This notice sets forth the Department of Energy's (DOE's) interpretation of its energy efficiency enforcement regulations. These regulations provide for manufacturer submission of compliance statements and certification reports

  11. Regulation of flexible arms under gravity

    SciTech Connect (OSTI)

    De Luca, A.; Siciliano, B.

    1993-08-01

    A simple controller is presented for the regulation problem of robot arms with flexible links under gravity. It consists of a joint PD feedback plus a constant feedforward. Global asymptotic stability of the reference equilibrium state is shown under a structural assumption about link elasticity and a mild condition on the proportional gain. The result holds also in the absence of internal damping of the flexible arm. A numerical case study is presented.

  12. Environmental Regulation Impacts on Eastern Interconnection Performance

    SciTech Connect (OSTI)

    Markham, Penn N; Liu, Yilu; Young II, Marcus Aaron

    2013-07-01

    In the United States, recent environmental regulations will likely result in the removal of nearly 30 GW of oil and coal-fired generation from the power grid, mostly in the Eastern Interconnection (EI). The effects of this transition on voltage stability and transmission line flows have previously not been studied from a system-wide perspective. This report discusses the results of power flow studies designed to simulate the evolution of the EI over the next few years as traditional generation sources are replaced with environmentally friendlier ones such as natural gas and wind.

  13. Self-regulating flow control device

    DOE Patents [OSTI]

    Humphreys, Duane A.

    1984-01-01

    A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.

  14. Ligand-specific regulation of the extracellular surface of a...

    Office of Scientific and Technical Information (OSTI)

    Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor Citation Details In-Document Search Title: Ligand-specific regulation of the extracellular ...

  15. 5 CCR 1002-64 Biosolids Regulation | Open Energy Information

    Open Energy Info (EERE)

    to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: 5 CCR 1002-64 Biosolids RegulationLegal Abstract Regulations implementing the Colorado...

  16. RCRA Notification of Regulated Waste Activity (EPA Form 8700...

    Open Energy Info (EERE)

    Notification of Regulated Waste Activity (EPA Form 8700-12) Jump to: navigation, search OpenEI Reference LibraryAdd to library Form: RCRA Notification of Regulated Waste Activity...

  17. Colorado Parks and Wildlife Rules and Regulations | Open Energy...

    Open Energy Info (EERE)

    Rules and Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Colorado Parks and Wildlife Rules and Regulations Abstract This web page lists...

  18. Code of Federal Regulations TRESPASSING ON DEPARTMENT OF ENERGY PROPERTY |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy TRESPASSING ON DEPARTMENT OF ENERGY PROPERTY Code of Federal Regulations TRESPASSING ON DEPARTMENT OF ENERGY PROPERTY The regulations in this part are issued for the protection and security of facilities, installations and real property subject to the jurisdiction or administration, or in the custody of, the Department of Energy. PDF icon Code of Federal Regulations TRESPASSING ON DEPARTMENT OF ENERGY PROPERTY More Documents & Publications Code of Federal Regulations

  19. Contacts for the Assistant General Counsel for Legislation, Regulation, and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Efficiency | Department of Energy Legislation, Regulation, and Energy Efficiency Contacts for the Assistant General Counsel for Legislation, Regulation, and Energy Efficiency Office of the Assistant General Counsel for Legislation, Regulation & Energy Efficiency (GC-33) Daniel Cohen, Assistant General Counsel for Legislation, Regulation, & Energy Efficiency 202-586-9523 daniel.cohen@hq.doe.gov Catherine Goshe, Attorney-Adviser 202-586-7053 Preeti Chaudhari, Attorney-Adviser

  20. Method to determine transcriptional regulation pathways in organisms

    Office of Scientific and Technical Information (OSTI)

    (Patent) | SciTech Connect Method to determine transcriptional regulation pathways in organisms Citation Details In-Document Search Title: Method to determine transcriptional regulation pathways in organisms The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for

  1. Using regulations.gov to find dockets and documents

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    regulations.gov to find dockets and documents Regulations.gov is a web-based repository of Federal regulatory documents. Publicly accessible documents associated with DOE Appliance and Equipment Standards rulemakings and related Federal Register notices are now accessible on regulations.gov On regulations.gov, you can: View Proposed and Final Rules and other regulatory documents or notices Read public comments, as well as public meeting presentations and transcripts These documents are part of a

  2. North America: Regulation of International Electricity Trade | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy America: Regulation of International Electricity Trade North America: Regulation of International Electricity Trade North America: Regulation of International Electricity Trade prepared by North American Energy Working Group on December 2002. PDF icon North America: Regulation of International Electricity Trade More Documents & Publications Regulatory Side-by-Side Governing Permitting of Cross-Border Electricity Transmission Facilities Between the United States and Canada Guide

  3. DOE Review of Regulations - Center for Regulatory Effectiveness Comments |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Review of Regulations - Center for Regulatory Effectiveness Comments DOE Review of Regulations - Center for Regulatory Effectiveness Comments The Center for Regulatory Effectiveness (CRE) is pleased to submit these comments to the Department of Energy (DOE) on how DOE can best review its existing regulations and to identify whether any of its existing regulations should be modified, streamlined, expanded or repealed. PDF icon

  4. EA-1631: Beacon Power Corporation Frequency Regulation Facility in

    Energy Savers [EERE]

    Stephentown, NY | Department of Energy 1: Beacon Power Corporation Frequency Regulation Facility in Stephentown, NY EA-1631: Beacon Power Corporation Frequency Regulation Facility in Stephentown, NY February 2, 2009 EA-1631: Final Environmental Assessment Loan Guarantee for Beacon Power Corporation Frequency Regulation Facility in Stephentown, New York February 27, 2009 EA-1631: Finding of No Significant Impact Loan Guarantee for Beacon Power Corporation Frequency Regulation Facility in

  5. QB1 - Stochastic Gene Regulation Munsky, Brian [Los Alamos National

    Office of Scientific and Technical Information (OSTI)

    FACILITIES; FLUCTUATIONS; GENE REGULATION; KINETICS; QUANTIZATION; SIMULATION; SWITCHES Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present...

  6. NARUC Releases Cybersecurity Primer for Utility Regulators (June 2012) |

    Energy Savers [EERE]

    Department of Energy NARUC Releases Cybersecurity Primer for Utility Regulators (June 2012) NARUC Releases Cybersecurity Primer for Utility Regulators (June 2012) June 14, 2012 - 4:50pm Addthis The National Association of Regulatory Utility Commissioners (NARUC) has released "Cybersecurity for State Regulators," a primer that explains conceptual cybersecurity basics and points to additional resources that can help regulators develop internal cybersecurity expertise, ask questions

  7. Guidance Regarding NEPA Regulations (CEQ, 1983) | Department of Energy

    Energy Savers [EERE]

    NEPA Regulations (CEQ, 1983) Guidance Regarding NEPA Regulations (CEQ, 1983) This document provides Council on Environmental Quality guidance on several topics: scoping, categorical exclusions, adoption procedures, contracting provisions, selection of alternatives in licensing and permitting situations, and tiering. PDF icon Guidance Regarding NEPA Regulations More Documents & Publications Final Guidance for Effective Use of Programmatic NEPA Review Forty Most Asked Questions Concerning

  8. Regulation of Viable and Optimal Cohorts

    SciTech Connect (OSTI)

    Aubin, Jean-Pierre

    2015-10-15

    This study deals with the evolution of (scalar) attributes (resources or income in evolutionary demography or economics, position in traffic management, etc.) of a population of “mobiles” (economic agents, vehicles, etc.). The set of mobiles sharing the same attributes is regarded as an instantaneous cohort described by the number of its elements. The union of instantaneous cohorts during a mobile window between two attributes is a cohort. Given a measure defining the number of instantaneous cohorts, the accumulation of the mobile attributes on a evolving mobile window is the measure of the cohort on this temporal mobile window. Imposing accumulation constraints and departure conditions, this study is devoted to the regulation of the evolutions of the attributes which are1.viable in the sense that the accumulations constraints are satisfied at each instant;2.and, among them, optimal, in the sense that both the duration of the temporal mobile window is maximum and that the accumulation on this temporal mobile window is the largest viable one. This value is the “accumulation valuation” function. Viable and optimal evolutions under accumulation constraints are regulated by an “implicit Volterra integro-differential inclusion” built from the accumulation valuation function, solution to an Hamilton–Jacobi–Bellman partial differential equation under constraints which is constructed for this purpose.

  9. Insight in the multilevel regulation of NER

    SciTech Connect (OSTI)

    Dijk, Madelon; Typas, Dimitris; Mullenders, Leon; Pines, Alex

    2014-11-15

    Nucleotide excision repair (NER) is a key component of the DNA damage response (DDR) and it is essential to safeguard genome integrity against genotoxic insults. The regulation of NER is primarily mediated by protein post-translational modifications (PTMs). The NER machinery removes a wide spectrum of DNA helix distorting lesions, including those induced by solar radiation, through two sub-pathways: global genome nucleotide excision repair (GG-NER) and transcription coupled nucleotide excision repair (TC-NER). Severe clinical consequences associated with inherited NER defects, including premature ageing, neurodegeneration and extreme cancer-susceptibility, underscore the biological relevance of NER. In the last two decades most of the core NER machinery has been elaborately described, shifting attention to molecular mechanisms that either facilitate NER in the context of chromatin or promote the timely and accurate interplay between NER factors and various post-translational modifications. In this review, we summarize and discuss the latest findings in NER. In particular, we focus on emerging factors and novel molecular mechanisms by which NER is regulated.

  10. Dancing with the regulations - Part Deux

    SciTech Connect (OSTI)

    Nitschke, R.L.

    1995-12-31

    The disposal of low-level radioactive waste (LLW) in the United States has long been subjected to two very similar regulations depending upon the location. Disposal sites located on Department of Energy (DOE) Reservations are subject to DOE Order 5820.2A {open_quotes}Radioactive Waste Management,{close_quotes} while disposal sites located elsewhere are subject to the Nuclear Regulatory Commission regulation 10 CFR 61 {open_quotes}Licensing Requirements for Land Disposal of Radioactive Waste.{close_quotes} While life was not necessarily good, there was only one sheet of music to dance to. Recently a new player, named CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act), has ridden into those DOE towns, and for those whose disposal facilities lie within or adjacent to Superfund sites, she has brought along a different drum to dance to. This paper discusses the differences and similarities between the different dance partners and their associated musical scores (i.e., the performance assessment (PA) required by the DOE order and the baseline risk assessment (BRA) required by CERCLA). The paper then provides a brief discussion on the latest dancer to cut in: the Defense Nuclear Facilities Safety Board (DNFSB). This discussion should help to alleviate the confusion while dancing on the LLW disposal regulatory ballroom floor.

  11. P70S6K 1 regulation of angiogenesis through VEGF and HIF-1{alpha} expression

    SciTech Connect (OSTI)

    Bian, Chuan-Xiu; Shi, Zhumei; Meng, Qiao; Jiang, Yue; Liu, Ling-Zhi; Jiang, Bing-Hua; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107

    2010-07-30

    Research highlights: {yields} P70S6K1 regulates VEGF expression; {yields} P70S6K1 induces transcriptional activation through HIF-1{alpha} binding site; {yields} P70S6K1 regulates HIF-1{alpha}, but not HIF-1{beta} protein expression; {yields} P70S6K1 mediates tumor growth and angiogenesis through HIF-1{alpha} and VEGF expression. -- Abstract: The 70 kDa ribosomal S6 kinase 1 (p70S6K1), a downstream target of phosphoinositide 3-kinase (PI3K) and ERK mitogen-activated protein kinase (MAPK), is an important regulator of cell cycle progression, and cell proliferation. Recent studies indicated an important role of p70S6K1 in PTEN-negative and AKT-overexpressing tumors. However, the mechanism of p70S6K1 in tumor angiogenesis remains to be elucidated. In this study, we specifically inhibited p70S6K1 activity in ovarian cancer cells using vector-based small interfering RNA (siRNA) against p70S6K1. We found that knockdown of p70S6K1 significantly decreased VEGF protein expression and VEGF transcriptional activation through the HIF-1{alpha} binding site at its enhancer region. The expression of p70S6K1 siRNA specifically inhibited HIF-1{alpha}, but not HIF-1{beta} protein expression. We also found that p70S6K1 down-regulation inhibited ovarian tumor growth and angiogenesis, and decreased cell proliferation and levels of VEGF and HIF-1{alpha} expression in tumor tissues. Our results suggest that p70S6K1 is required for tumor growth and angiogenesis through HIF-1{alpha} and VEGF expression, providing a molecular mechanism of human ovarian cancer mediated by p70S6K1 signaling.

  12. Is anyone regulating naturally occurring radioactive material? A state survey

    SciTech Connect (OSTI)

    Gross, E.M.; Barisas, S.G.

    1993-08-01

    As far as we know, naturally occurring radioactive material (NORM) has surrounded humankind since the beginning of time. However, recent data demonstrating that certain activities concentrate NORM have increased concern regarding its proper handling and disposal and precipitated the development of new NORM-related regulations. The regulation of NORM affects the management of government facilities as well as a broad range of industrial processes. Recognizing that NORM regulation at the federal level is extremely limited, Argonne National Laboratory (ANL) conducted a 50-state survey to determine the extent to which states have assumed the responsibility for regulating NORM as well as the NORM standards that are currently being applied at the state level. Though the survey indicates that NORM regulation comprises a broad spectrum of controls from full licensing requirements to virtually no regulation at afl, a trend is emerging toward recognition of the need for increased regulation of potential NORM hazards, particularly in the absence of federal standards.

  13. When regulations go too far the taking of private property by environmental regulations

    SciTech Connect (OSTI)

    Plott, D.M.

    1995-12-01

    Seventy years ago Justice Oliver Wendell Homes wrote in an Opinion of the United States Supreme Court that{open_quotes}...while property may be regulated to a certain extent, if regulation goes too far it will be recognized as a taking.{close_quotes} Pennsylvania Coal Co. v. Mahon, 260 U.S. 393 (1992) The Fifth Amendment of the United States Constitution provides that private property shall not be {open_quotes}taken for public use, without just compensation{close_quotes}. After lying dormant for half a century, the {open_quotes}takings{close_quotes} clause of the United States constitution is being invoked to challenge environmental regulations throughout the country. In essence, property owners are saying that if the government wants to regulate to protect wetlands, wildlife habitat and other natural resources it must pay just compensation to the property owners for the restrictions imposed upon the use of their land. During the past ten years, the U.S. Supreme Court has decided several takings cases. While the judicial branch of government has become increasingly active in takings cases, the U.S. Congress and State legislatures have also been extremely active in efforts to protect private property rights. Typically, these legislative requires a takings impact analysis by the government to determine if its actions are likely to result in the compensable taking of private property or require compensation if property values are reduced by a certain percentage. This paper reviews the judicial standards that have been established for reviewing taking claims and sets forth a framework for analyzing when a regulation goes {open_quotes}too far{close_quotes} so as to require payment of compensation.

  14. System and method for regulating resonant inverters

    DOE Patents [OSTI]

    Stevanovic, Ljubisa Dragoljub (Clifton Park, NY); Zane, Regan Andrew (Superior, CO)

    2007-08-28

    A technique is provided for direct digital phase control of resonant inverters based on sensing of one or more parameters of the resonant inverter. The resonant inverter control system includes a switching circuit for applying power signals to the resonant inverter and a sensor for sensing one or more parameters of the resonant inverter. The one or more parameters are representative of a phase angle. The resonant inverter control system also includes a comparator for comparing the one or more parameters to a reference value and a digital controller for determining timing of the one or more parameters and for regulating operation of the switching circuit based upon the timing of the one or more parameters.

  15. Body temperature regulation during euthermia and hyperthermia

    SciTech Connect (OSTI)

    Shimada, S.G.; Stitt, J.T.

    1981-10-01

    In this paper we have presented a few fundamental principles which are essential for an understanding of how microwaves might affect body temperature regulation. Application of the heat balance equation requires an accounting of all heat losses and heat gains. Thus, experimental measurements of these two processes are usually required to explain any thermoregulatory response. Knowledge of the individual elements of the thermoregulatory system and their integrative operation is imperative. Without such information one cannot hope to analyze or predict the consequences of microwave irradiation, or to separate simple heating effects from possible nonthermal effects. Finally, we have tried to emphasize that hyperthermia can be produced in different ways. Thus, there may be several forms of microwave hyperthermia, differing in their causality. Deposition of microwave energy in deep tissues might produce a response similar to exercise hyperthermia.

  16. Economics and regulation of petroleum futures markets

    SciTech Connect (OSTI)

    Not Available

    1980-08-01

    Because the futures market in petroleum products is a relatively recent phenomenon, the implications of public policies formulated for that market have not yet been fully explored. To provide the Office of Competition of the Department of Energy (DOE) with sufficient information to assess policy alternatives, Resource Planning Associates, Inc. (RPA) was asked to analyze the development of the futures market in No. 2 oil, assess the potential for futures markets in other petroleum products, and identify policy alternatives available to DOE. To perform this analysis, the criteria for a viable futures market was established first. Then, the experience to date with the 18-month-old futures market in No. 2 oil was examined, and the potential for viable futures markets in No. 6 oil, gasoline, jet fuel, and crude oil was assessed. Finally, how existing DOE regulations and prospective actions might affect petroleum futures market development was investigated.

  17. Colorado geothermal institutional handbook: a user's guide of agencies regulations, permits, and aids for geothermal development

    SciTech Connect (OSTI)

    Coe, B.A.; Forman, N.A.

    1980-01-01

    The following are included: principal state agencies, applicable state legislation, applicable state regulations, local agencies and regulations, federal agencies and regulations, information sources, and agencies and individuals. (MHR)

  18. Incentive regulation of investor-owned nuclear power plants by public utility regulators. Revision 1

    SciTech Connect (OSTI)

    McKinney, M.D.; Seely, H.E.; Merritt, C.R.; Baker, D.C.

    1995-04-01

    The US Nuclear Regulatory Commission (NRC) periodically surveys the Federal Energy Regulatory Commission (FERC) and state regulatory commissions that regulate utility owners of nuclear power plants. The NRC is interested in identifying states that have established economic or performance incentive programs applicable to nuclear power plants, how the programs are being implemented, and in determining the financial impact of the programs on the utilities. The NRC interest stems from the fact that such programs have the potential to adversely affect the safety of nuclear power plants. The current report is an update of NUREG/CR-5975, Incentive Regulation of Investor-Owned Nuclear Power Plants by Public Utility Regulators, published in January 1993. The information in this report was obtained from interviews conducted with each state regulatory agency that administers an incentive program and each utility that owns at least 10% of an affected nuclear power plant. The agreements, orders, and settlements that form the basis for each incentive program were reviewed as required. The interviews and supporting documentation form the basis for the individual state reports describing the structure and financial impact of each incentive program.

  19. Chapter 1 - Acquisition Regulations System | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    - Acquisition Regulations System Chapter 1 - Acquisition Regulations System PDF icon 1.1_Acquisition_Regulation_System_0.pdf PDF icon 1.2_Head_of_Contracting_Activity_(HCA)_Authority,_Functions,_and_Responsibilities.pdf PDF icon DOE Procurement Directors' Directory PDF icon Other DOE HCA List May 26 2015.pdf PDF icon 1.2_Attachment_Tables_I-IV_0.pdf PDF icon 1.3_Balanced_Scorecard_Assessment_Program_0.pdf PDF icon

  20. Code of Federal Regulations OCCUPATIONAL RADIATION PROTECTION | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy OCCUPATIONAL RADIATION PROTECTION Code of Federal Regulations OCCUPATIONAL RADIATION PROTECTION The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities. PDF icon Code of Federal Regulations OCCUPATIONAL RADIATION PROTECTION More Documents & Publications Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A - General

  1. Contacts for the Deputy General Counsel for Litigation, Regulation and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Enforcement (GC-30) | Department of Energy Litigation, Regulation and Enforcement (GC-30) Contacts for the Deputy General Counsel for Litigation, Regulation and Enforcement (GC-30) Anne Harkavy, Deputy General Counsel for Litigation, Regulation, and Enforcement 202-586-8700 anne.harkavy@hq.doe.gov Margie L. Washington, Administrative Support Specialist 202-586-8700 202-586-3437 (fax) margie.washington@hq.doe.gov

  2. Estrogen induced {beta}-1,4-galactosyltransferase 1 expression regulates

    Office of Scientific and Technical Information (OSTI)

    proliferation of human breast cancer MCF-7 cells (Journal Article) | SciTech Connect Estrogen induced {beta}-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells Citation Details In-Document Search Title: Estrogen induced {beta}-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells Highlights: Black-Right-Pointing-Pointer We examined the regulation and biological functions of B4GALT1 expression induced

  3. Natural Gas Regulation - Other Gas-Related Information Sources | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Natural Gas Regulation - Other Gas-Related Information Sources Natural Gas Regulation - Other Gas-Related Information Sources The single largest source of energy information available is the Department of Energy's Energy Information Administration (EIA). The EIA publishes extensive reports on natural gas and other energy sources. Domestic natural gas markets are regulated in part by the Federal Energy Regulatory Commission. The commission's chief area of concern is the interstate

  4. Building Codes and Regulations for Solar Water Heating Systems | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Codes and Regulations for Solar Water Heating Systems Building Codes and Regulations for Solar Water Heating Systems Photo Credit: iStockphoto Photo Credit: iStockphoto Before installing a solar water heating system, you should investigate local building codes, zoning ordinances, and subdivision covenants, as well as any special regulations pertaining to the site. You will probably need a building permit to install a solar energy system onto an existing building. Not every

  5. Harmonization of Federal and International Regulations | Department of

    Energy Savers [EERE]

    Energy Harmonization of Federal and International Regulations Harmonization of Federal and International Regulations Update of the U.S. Department of Transportation (DOT) Pipeline and Hazardous Materials Safety Administration (PHMSA). PDF icon Harmonization of Federal and International Regulations More Documents & Publications DOE-STD-5507-2013 Department of Transportation Pipeline and Hazardous Materials Safety Administration Activities FAQS Reference Guide - NNSA Package Certification

  6. Vehicle Technologies Office: Regulated Fleets | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Alternative Fuels » Vehicle Technologies Office: Regulated Fleets Vehicle Technologies Office: Regulated Fleets The Office of Energy Efficiency and Renewable Energy (EERE) manages several programs designed to fulfill the requirements of the original and amended versions of the Energy Policy Act of 1992 (EPAct) that regulate and guide specific types of fleets with the goal of reducing the United States' petroleum consumption. EERE's Vehicle Technologies Office (VTO) implements the EPAct

  7. Office of the Assistant General Counsel for Legislation, Regulation and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Efficiency | Department of Energy Legislation, Regulation and Energy Efficiency Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency The Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency (GC-33) provides legal support and advice on legislative matters throughout the Department. It participates in the development of DOE views on pending legislation, drafts DOE legislative proposals and supporting documents,

  8. Energy Department Revises NEPA Regulations to Improve Efficiency |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Revises NEPA Regulations to Improve Efficiency Energy Department Revises NEPA Regulations to Improve Efficiency October 3, 2011 - 12:39pm Addthis Washington, D.C. -- The U.S. Department of Energy will save time and money in its environmental reviews of many proposed energy projects under revised regulations approved September 27, 2011, to implement the National Environmental Policy Act (NEPA). The revisions focus on the Department's categorical exclusion provisions, and

  9. Photoperiodic Regulation of the Seasonal Pattern of Photosynthetic Capacity and the Implications for Carbon Cycling

    SciTech Connect (OSTI)

    Bauerle, William L.; Oren, Ram; Way, Danielle A.; Qian, Song S.; Stoy, Paul C.; Thornton, Peter E; Bowden, Joseph D.; Hoffman, Forrest M; Reynolds, Robert F.

    2012-01-01

    Although temperature is an important driver of seasonal changes in photosynthetic physiology, photoperiod also regulates leaf activity. Climate change will extend growing seasons if temperature cues predominate, but photoperiod-controlled species will show limited responsiveness to warming. We show that photoperiod explains more seasonal variation in photosynthetic activity across 23 tree species than temperature. Although leaves remain green, photosynthetic capacity peaks just after summer solstice and declines with decreasing photoperiod, before air temperatures peak. In support of these findings, saplings grown at constant temperature but exposed to an extended photoperiod maintained high photosynthetic capacity, but photosynthetic activity declined in saplings experiencing a naturally shortening photoperiod; leaves remained equally green in both treatments. Incorporating a photoperiodic correction of photosynthetic physiology into a global-scale terrestrial carbon-cycle model significantly improves predictions of seasonal atmospheric CO{sub 2} cycling, demonstrating the benefit of such a function in coupled climate system models. Accounting for photoperiod-induced seasonality in photosynthetic parameters reduces modeled global gross primary production 2.5% ({approx}4 PgC y{sup -1}), resulting in a >3% ({approx}2 PgC y{sup -1}) decrease of net primary production. Such a correction is also needed in models estimating current carbon uptake based on remotely sensed greenness. Photoperiod-associated declines in photosynthetic capacity could limit autumn carbon gain in forests, even if warming delays leaf senescence.

  10. 50 CFR 216 - Regulations Governing the Taking and Importing of...

    Open Energy Info (EERE)

    50 CFR 216 - Regulations Governing the Taking and Importing of Marine Mammals Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  11. A Utility Regulator's Guide to Data Access for Commercial Building...

    Broader source: Energy.gov (indexed) [DOE]

    use data to help commercial customers manage energy costs through building energy benchmarking. A Utility Regulator's Guide to Data Access for Commercial Building Energy...

  12. DOE's Program Regulating Liquefied Natural Gas Export Applications...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DOE's Program Regulating Liquefied Natural Gas Export Applications June 18, 2013 - 10:15am Addthis Statement of Christopher Smith, Acting Assistant Secretary for Fossil Energy ...

  13. USACE Engineer Regulation 1110-2-1454 Corps Responsibilities...

    Open Energy Info (EERE)

    USACE Engineer Regulation 1110-2-1454 Corps Responsibilities for Non-Federal Hydroelectric Power Development under the Federal Power Act Jump to: navigation, search OpenEI...

  14. Chapter 1 of the Wyoming Public Service Commission Regulations...

    Open Energy Info (EERE)

    of the Wyoming Public Service Commission Regulations: Rules of Practice and Procedure Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  15. Title 22 California Code of Regulations | Open Energy Information

    Open Energy Info (EERE)

    Abstract Title 22 California Code of Regulations, current through August 7, 2014. Published NA Year Signed or Took Effect 2014 Legal Citation Title 22 California Code...

  16. Rules and Regulations of the Department of Transportation, Chapter...

    Open Energy Info (EERE)

    of Transportation, Chapter 13 - Access FacilitiesLegal Abstract This chapter sets forth Department of Transportation rules and regulations governing access facilities....

  17. TEEIC Laws and Regulations Applicable to Energy Transmission...

    Open Energy Info (EERE)

    TEEIC Laws and Regulations Applicable to Energy Transmission Development Website Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: TEEIC Laws and...

  18. Geothermal Regulations in Colorado - Land Ownership is the Key...

    Open Energy Info (EERE)

    Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Paper: Geothermal Regulations in Colorado - Land Ownership is the Key Abstract Geothermal resources in...

  19. Biomass Boiler and Furnace Emissions and Safety Regulations in...

    Open Energy Info (EERE)

    in the Northeast States Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Biomass Boiler and Furnace Emissions and Safety Regulations in the Northeast States Agency...

  20. Applicable EPA Regulations and Description Website | Open Energy...

    Open Energy Info (EERE)

    provides information regarding EPA regulations that apply to brownfields grants. Author Environmental Protection Agency Published EPA, Date Not Provided DOI Not Provided Check...

  1. A Regulator's Perspective on Interpretation of Performance and...

    Office of Environmental Management (EM)

    Interpretation of Performance and Risk Assessment Results A Regulator's Perspective on Interpretation of Performance and Risk Assessment Results Presentation from the 2015 Annual...

  2. Comments Received on Proposed Rulemaking for regulation implementing...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    section 216(h): Coordination of Federal Transmission Permitting on Federal Lands Comments Received on Proposed Rulemaking for regulation implementing section 216(h): Coordination ...

  3. EO 13211: Regulations That Significantly Affect Energy Supply...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Executive Order 13211 of May 18, 2001 Actions Concerning Regulations That Significantly ... present the related submission under Executive Order 12866 of September 30, 1993, or ...

  4. ADR Provisions in Federal Acquisition Regulation (FAR) | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation (FAR) More Documents & Publications Microsoft Word - ADR-Provisions-FederalAcquisitionReg.doc ACQUISITION LETTER DEAR Part 933 Microsoft Word - ACQUISITION LETTER.doc...

  5. Providing Minute-to-Minute Regulation from Wind Plants: Preprint

    SciTech Connect (OSTI)

    Kirby, B.; Milligan, M.; Ela, E.

    2010-10-01

    In this paper, we extend the previous analysis using time series data from existing wind plants, system loads, and regulation and energy markets.

  6. Control and regulation of modern distribution system, ForskEL...

    Open Energy Info (EERE)

    system, ForskEL (Smart Grid Project) Jump to: navigation, search Project Name Control and regulation of modern distribution system, ForskEL Country Denmark Coordinates...

  7. Distribution System Voltage Regulation by Distributed Energy Resources

    SciTech Connect (OSTI)

    Ceylan, Oguzhan; Liu, Guodong; Xu, Yan; Tomsovic, Kevin

    2014-01-01

    This paper proposes a control method to regulate voltages in 3 phase unbalanced electrical distribution systems. A constrained optimization problem to minimize voltage deviations and maximize distributed energy resource (DER) active power output is solved by harmony search algorithm. IEEE 13 Bus Distribution Test System was modified to test three different cases: a) only voltage regulator controlled system b) only DER controlled system and c) both voltage regulator and DER controlled system. The simulation results show that systems with both voltage regulators and DER control provide better voltage profile.

  8. Council on Environmental Quality (CEQ) NEPA Regulations: 40 CFR...

    Open Energy Info (EERE)

    LibraryAdd to library Legal Document- Secondary Legal SourceSecondary Legal Source: Council on Environmental Quality (CEQ) NEPA Regulations: 40 CFR 1500 - 1518Legal Author CEQ...

  9. Effective Regulatory Institutions: The Regulator's Role in the...

    Open Energy Info (EERE)

    Regulatory Institutions: The Regulator's Role in the Policy Process, Including Issues of Regulatory Independence Jump to: navigation, search Tool Summary LAUNCH TOOL Name:...

  10. Strategic Energy Management for Regulators of Ratepayer-Funded Programs

    SciTech Connect (OSTI)

    Existing Commercial Buildings Working Group

    2012-05-23

    Provides regulators with information on how to design and implement whole-building, continuous-improvement energy management programs for commercial buildings.

  11. Policy Flash 2013-23 Department of Energy Acquisition Regulation...

    Broader source: Energy.gov (indexed) [DOE]

    Attached is Policy Flash 2013-23 Department of Energy Acquisition Regulation (DEAR) Final Rule for changes to Parts 908, 945, 952, and 970 regarding Government Property. Questions...

  12. Activation of 200 MW refusegenerated CHP upward regulation effect...

    Open Energy Info (EERE)

    regulation effect Country Denmark Headquarters Location Thisted, Denmark Coordinates 56.959167, 8.703492 Loading map... "minzoom":false,"mappingservice":"googlemaps3","typ...

  13. Standards for Municipal Small Wind Regulations and Model Ordinance

    Broader source: Energy.gov [DOE]

    In July 2008, New Hampshire enacted legislation designed to prevent municipalities from adopting ordinances or regulations that place unreasonable limits on or hinder the performance of wind energy...

  14. Acquisition Guide Chapter 1.0- Acquisition Regulations System

    Broader source: Energy.gov [DOE]

    This section discusses the Civilian Agency Acquisition Council, agency acquisition regulations, deviations from the FAR and DEAR, ratification of unauthorized commitments, and Contracting Officers and their representatives.

  15. Re: Request for Information on Regulatory Burden of DOE Regulations...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PDF icon Re: Request for Information on Regulatory Burden of DOE Regulations More Documents & Publications Edison Electric Institute (EEI) Reducing Regulatory Burden RFI, 77 Fed. ...

  16. 5 CCR 1002-82 401 Certification Regulation | Open Energy Information

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 5 CCR 1002-82 401 Certification RegulationLegal Abstract Implementing regulations that...

  17. 10 V.S.A. Chapter 41 Regulation of Stream Flow | Open Energy...

    Open Energy Info (EERE)

    1 Regulation of Stream Flow Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 10 V.S.A. Chapter 41 Regulation of Stream...

  18. Title 10 Chapter 41 Regulation of Stream Flow | Open Energy Informatio...

    Open Energy Info (EERE)

    41 Regulation of Stream Flow Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Title 10 Chapter 41 Regulation of Stream...

  19. cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction

    SciTech Connect (OSTI)

    Son, Jieun; Lee, Jong-Ho; Kim, Ha-Neui; Ha, Hyunil Lee, Zang Hee

    2010-07-23

    Research highlights: {yields} CREB is highly expressed in advanced breast cancer cells. {yields} Tumor-related factors such as TGF-{beta} further elevate CREB expression. {yields} CREB upregulation stimulates metastatic potential of breast cancer cells. {yields} CREB signaling is required for breast cancer-induced bone destruction. -- Abstract: cAMP-response-element-binding protein (CREB) signaling has been reported to be associated with cancer development and poor clinical outcome in various types of cancer. However, it remains to be elucidated whether CREB is involved in breast cancer development and osteotropism. Here, we found that metastatic MDA-MB-231 breast cancer cells exhibited higher CREB expression than did non-metastatic MCF-7 cells and that CREB expression was further increased by several soluble factors linked to cancer progression, such as IL-1, IGF-1, and TGF-{beta}. Using wild-type CREB and a dominant-negative form (K-CREB), we found that CREB signaling positively regulated the proliferation, migration, and invasion of MDA-MB-231 cells. In addition, K-CREB prevented MDA-MB-231 cell-induced osteolytic lesions in a mouse model of cancer metastasis. Furthermore, CREB signaling in cancer cells regulated the gene expression of PTHrP, MMPs, and OPG, which are closely involved in cancer metastasis and bone destruction. These results indicate that breast cancer cells acquire CREB overexpression during their development and that this CREB upregulation plays an important role in multiple steps of breast cancer bone metastasis.

  20. Emerging Latin American air quality regulation

    SciTech Connect (OSTI)

    Hosmer, A.W.; Vitale, E.M.; Guerrero, C.R.; Solorzano-Vincent, L.

    1998-12-31

    Latin America is the most urbanized region in the developing world. In recent years, significant economic growth has resulted in population migration from rural areas to urban centers, as well as in a substantial rise in the standard of living within the Region. These changes have impacted the air quality of Latin American countries as increased numbers of industrial facilities and motor vehicles release pollutants into the air. With the advent of new free trade agreements such as MERCOSUR and NAFTA, economic activity and associated pollutant levels can only be expected to continue to expand in the future. In order to address growing air pollution problems, many Latin America countries including Argentina, Brazil, Chile, Columbia, Costa Rica, and Mexico have passed, or will soon pass, new legislation to develop and strengthen their environmental frameworks with respect to air quality. As a first step toward understanding the impacts that this increased environmental regulation will have, this paper will examine the regulatory systems in six Latin American countries with respect to ambient air quality and for each of these countries: review a short history of the air quality problems within the country; outline the legal and institutional framework including key laws and implementing institutions; summarize in brief the current status of the country in terms of program development and implementation; and identify projected future trends. In addition, the paper will briefly review the international treaties that have bearing on Latin American air quality. Finally, the paper will conclude by identifying and exploring emerging trends in individual countries and the region as a whole.

  1. Experimental validation of advanced regulations for superconducting magnet cooling undergoing periodic heat loads

    SciTech Connect (OSTI)

    Lagier, B.; Rousset, B.; Hoa, C.; Bonnay, P.

    2014-01-29

    Superconducting magnets used in tokamaks undergo periodic heat load caused by cycling plasma operations inducing AC losses, neutrons fluxes and eddy currents in magnet structures. In the cryogenic system of JT60-SA tokamak, the Auxiliary Cold Box (ACB) distributes helium from the refrigerator to the cryogenic users and in particular to the superconducting magnets. ACB comprises a saturated helium bath with immersed heat exchangers, extracting heat from independent cooling loops. The supercritical helium flow in each cooling loop is driven by a cold circulator. In order to safely operate the refrigerator during plasma pulses, the interface between the ACB and the refrigerator shall be as stable as possible, with well-balanced bath inlet and outlet mass flows during cycling operation. The solution presented in this paper relies on a combination of regulations to smooth pulsed heat loads and to keep a constant refrigeration power during all the cycle. Two smoothing strategies are presented, both regulating the outlet mass flow of the bath: the first one using the bath as a thermal buffer and the second one storing energy in the loop by varying the cold circulator speed. The bath outlet mass flow is also controlled by an immersed resistive heater which enables a constant evaporation rate in the bath when power coming from the loops is decreasing. The refrigeration power is controlled so that the compensating power remains within an acceptable margin. Experimental validation is achieved using the HELIOS facility. This facility running at CEA Grenoble since 2010 is a scaled down model of the ACB bath and Central Solenoid magnet cooling loop of the JT60-SA tokamak. Test results show performances and robustness of the regulations.

  2. Mechanically stimulated bone cells secrete paracrine factors that regulate

    Office of Scientific and Technical Information (OSTI)

    osteoprogenitor recruitment, proliferation, and differentiation (Journal Article) | SciTech Connect Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation Citation Details In-Document Search Title: Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation Bone formation requires the recruitment, proliferation and osteogenic

  3. Federal Regulations for Natural Gas Imports and Exports | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Federal Regulations for Natural Gas Imports and Exports Federal Regulations for Natural Gas Imports and Exports PDF icon Section 3 of the Natural Gas Act More Documents & Publications Appendix B Patent and copyright cases 42 USC 17013

  4. US Removes Last Remaining HEU from Czech Republic, Sets Nonproliferati...

    National Nuclear Security Administration (NNSA)

    never acquire a nuclear weapon, and our work ... into low enriched uranium (LEU) for use in power reactors. ... NNSA maintains and enhances the safety, security, ...

  5. FAL 2006-04, Financial Assistance Letters Remaining in Effect

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Letters Discontinued Number Date Subject Disposition 2004-03 02122004 Intellectual Property Moved to the Guide to Financial Assistance 2004-06 11022004 Award Terms Moved ...

  6. EM's Cleanup Mission: 16 Sites in 11 States Remaining

    Broader source: Energy.gov [DOE]

    At the end of fiscal year 2013, EM completed cleanup and closed 90 sites in 28 states. This included cleanup and closure of 85 smaller sites and five major nuclear sites: Rocky Flats, Fernald, Mound, Pinellas, and Weldon Spring.

  7. U.S. gasoline prices remain steady (long version)

    U.S. Energy Information Administration (EIA) Indexed Site

    Prices were lowest in the Gulf Coast states at 2.54 a gallon, up 5.3 cents. This is Marlana Anderson, with EIA, in Washington. For more information, contact Marlana Anderson, ...

  8. United States, International Partners Remove Last Remaining Weapons...

    Broader source: Energy.gov (indexed) [DOE]

    on a broad range of nuclear security and nonproliferation activities. These include border security and export control cooperation, safeguards information management, and...

  9. NNSA Partnership Successfully Removes All Remaining HEU from...

    National Nuclear Security Administration (NNSA)

    ... application of nuclear science. NNSA maintains and enhances the safety, security, reliability and performance of the U.S. nuclear weapons stockpile without nuclear testing; works ...

  10. U.S. diesel fuel prices remain stable

    U.S. Energy Information Administration (EIA) Indexed Site

    That's up 1.3 cents from a week ago, based on the weekly price survey by the U.S. Energy Information Administration. Diesel prices were highest in the West Coast states at 2.33 a ...

  11. U.S. diesel fuel prices remain stable

    U.S. Energy Information Administration (EIA) Indexed Site

    That's based on the weekly price survey by the U.S. Energy Information Administration. Diesel prices were highest in the West Coast states at 2.32 a gallon, up 2-tenths of a penny ...

  12. A National Forum on Demand Response: Results on What Remains...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Part of the July 2011 Implementation Proposal called for a "National Forum" on demand response to be conducted by DOE and FERC. Given the rapid development of the demand response ...

  13. Questions remain on funding for cleanup of Oak Ridge Reservation

    Broader source: Energy.gov [DOE]

    There is great uncertainty on what the looming federal budget cuts will be and what effect they will have on funding for the Department of Energys (DOE) Environmental Management (EM) program at the Oak Ridge Reservation (ORR).

  14. Investment in generation is heavy, but important needs remain

    SciTech Connect (OSTI)

    Maize, K.

    2007-01-15

    Forecasting the direction of the US electric power industry for 2007, much less the distant future, is like defining a velocity vector; doing so requires a direction and speed to delineate progress. In this special report, the paper looks at current industry indicators and draws conclusions based on more than 100 years of experience. To borrow verbatim the title of basketball legend Charles Barkely's book 'I may be wrong but I doubt it'. The forecast takes into consideration USDOE's National Electric Transmission Congestion Study (August 2006),a summary of industry data prepared by Industrial Info Resources (IIR) and NERC's 2006 Long-Term Reliability Assessment (October 2006). It also reports opinions of industry specialists. 3 figs., 4 tabs.

  15. United States Collaborates with Switzerland to Remove Last Remaining...

    National Nuclear Security Administration (NNSA)

    ... NNSA maintains and enhances the safety, security, and effectiveness of the U.S. nuclear weapons stockpile without nuclear explosive testing; works to reduce the global danger from ...

  16. Voltage Regulator Chip: Power Supplies on a Chip

    SciTech Connect (OSTI)

    2010-09-01

    ADEPT Project: CPES at Virginia Tech is finding ways to save real estate on a computer's motherboard that could be used for other critical functions. Every computer processor today contains a voltage regulator that automatically maintains a constant level of electricity entering the device. These regulators contain bulky components and take up about 30% of a computer's motherboard. CPES at Virginia Tech is developing a voltage regulator that uses semiconductors made of gallium nitride on silicon (GaN-on-Si) and high-frequency soft magnetic material. These materials are integrated on a small, 3D chip that can handle the same amount of power as traditional voltage regulators at 1/10 the size and with improved efficiency. The small size also frees up to 90% of the motherboard space occupied by current voltage regulators.

  17. Immunities from the antitrust laws for regulated entities

    SciTech Connect (OSTI)

    Jones, M.B.

    1985-05-30

    Just as regulation is an ever-present and crucial factor in most of the day-to-day operating decisions of regulated natural gas transmission and distribution companies, it is also an important factor to consider in assessing the application of the antitrust laws to the conduct of these regulated entities. The legal guidelines are far from clear and are evolving. However, as regulated entities find themselves in an ever more competitive environment, it becomes necessary for their legal counsel to monitor closely the developments in the law concerning immunities from the antitrust laws by virtue of regulation imposed by government. The author hopes that this article will provide a useful starting point for that analysis.

  18. A regulator`s perspective on NRC`s participation in the operations & maintenance committees

    SciTech Connect (OSTI)

    Wessman, R.H.

    1996-12-01

    As a regulator fairly new to the American Society of Mechanical Engineers (ASME) Operations and Maintenance (O&M) Committee process, the author does not have a personal historical perspective as do many of the longer-term, and highly respected, members of the O&M Committee. However, as Branch Chief of the Mechanical Engineering Branch, Division of Engineering, in the Office of Nuclear Reactor Regulation at the NRC for just over two years, he has responsibility for the regulatory agency`s review of licensee actions involving the products that come from the efforts of the O&M Committee, as well as responsibility for portions of the activities of interest to other ASME Code groups such as Section III, Section XI, and Qualification of Mechanical Equipment. As a result, the author has learned a great deal about the code process in a short time. Here he gives his perspectives on the process and provides a few thoughts on the direction for the future.

  19. Structure-based functional characterization of repressor of toxin (Rot), a central regulator of staphylococcus aureus virulence

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Killikelly, April; Jakoncic, Jean; Benson, Meredith A.; Ohneck, Elizabeth A.; Sampson, Jared M.; Spurrier, Brett; Torres, Victoer J.; Kong, Xian -Peng

    2014-10-20

    Staphylococcus aureus is responsible for a large number of diverse infections worldwide. In order to support its pathogenic lifestyle, S. aureus has to regulate the expression of virulence factors in a coordinated fashion. One of the central regulators of the S. aureus virulence regulatory networks is the transcription factor repressor of toxin (Rot). Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors. However, the mechanism by which Rot mediates gene regulation has remained elusive. Here, we have determined the crystal structure ofmore » Rot and used this information to probe the contribution made by specific residues to Rot function. Rot was found to form a dimer, with each monomer harboring a winged helix-turn-helix (WHTH) DNA-binding motif. Despite an overall acidic pI, the asymmetric electrostatic charge profile suggests that Rot can orient the WHTH domain to bind DNA. Structure-based site-directed mutagenesis studies demonstrated that R91, at the tip of the wing, plays an important role in DNA binding, likely through interaction with the minor groove. We also found that Y66, predicted to bind within the major groove, contributes to Rot interaction with target promoters. Evaluation of Rot binding to different activated and repressed promoters revealed that certain mutations on Rot exhibit promoter-specific effects, suggesting for the first time that Rot differentially interacts with target promoters. As a result, this work provides insight into a precise mechanism by which Rot controls virulence factor regulation in S. aureus.« less

  20. Structure-based functional characterization of Repressor of Toxin (Rot), a central regulator of Staphylococcus aureus virulence

    SciTech Connect (OSTI)

    Killikelly, April [New York Univ. School of Medicine, NY (United States). Dept. of Biochemistry and Molecular Pharmacology; Jakoncic, Jean [Brookhaven National Laboratory (BNL), Upton, NY (United States). Photon Sciences Directorate; Benson, Meredith A. [New York Univ. School of Medicine, NY (United States). Dept. of Microbiology; Ohneck, Elizabeth A. [New York Univ. School of Medicine, NY (United States). Dept. of Microbiology; Sampson, Jared M. [New York Univ. School of Medicine, NY (United States). Dept. of Biochemistry and Molecular Pharmacology; Spurrier, Brett [New York Univ. School of Medicine, NY (United States). Dept. of Biochemistry and Molecular Pharmacology; Torres, Victoer J. [New York Univ. School of Medicine, NY (United States). Dept. of Microbiology; Kong, Xian-Peng [New York Univ. School of Medicine, NY (United States). Dept. of Biochemistry and Molecular Pharmacology

    2014-10-20

    Staphylococcus aureus is responsible for a large number of diverse infections worldwide. In order to support its pathogenic lifestyle, S. aureus has to regulate the expression of virulence factors in a coordinated fashion. One of the central regulators of the S. aureus virulence regulatory networks is the transcription factor repressor of toxin (Rot). Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors. However, the mechanism by which Rot mediates gene regulation has remained elusive. Here, we have determined the crystal structure of Rot and used this information to probe the contribution made by specific residues to Rot function. Rot was found to form a dimer, with each monomer harboring a winged helix-turn-helix (WHTH) DNA-binding motif. Despite an overall acidic pI, the asymmetric electrostatic charge profile suggests that Rot can orient the WHTH domain to bind DNA. Structure-based site-directed mutagenesis studies demonstrated that R91, at the tip of the wing, plays an important role in DNA binding, likely through interaction with the minor groove. We also found that Y66, predicted to bind within the major groove, contributes to Rot interaction with target promoters. Evaluation of Rot binding to different activated and repressed promoters revealed that certain mutations on Rot exhibit promoter-specific effects, suggesting for the first time that Rot differentially interacts with target promoters. This work provides insight into a precise mechanism by which Rot controls virulence factor regulation in S. aureus.

  1. A primer on incentive regulation for electric utilities

    SciTech Connect (OSTI)

    Hill, L.J.

    1995-10-01

    In contemplating a regulatory approach, the challenge for regulators is to develop a model that provides incentives for utilities to engage in socially desirable behavior. In this primer, we provide guidance on this process by discussing (1) various models of economic regulation, (2) problems implementing these models, and (3) the types of incentives that various models of regulation provide electric utilities. We address five regulatory models in depth. They include cost-of-service regulation in which prudently incurred costs are reflected dollar-for-dollar in rates and four performance-based models: (1) price-cap regulation, in which ceilings are placed on the average price that a utility can charge its customers; (2) revenue-cap regulation, in which a ceiling is placed on revenues; (3) rate-of-return bandwidth regulation, in which a utility`s rates are adjusted if earnings fall outside a {open_quotes}band{close_quotes} around equity returns; and (4) targeted incentives, in which a utility is given incentives to improve specific components of its operations. The primary difference between cost-of-service and performance-based approaches is the latter sever the tie between costs and prices. A sixth, {open_quotes}mixed approach{close_quotes} combines two or more of the five basic ones. In the recent past, a common mixed approach has been to combine targeted incentives with cost-of-service regulation. A common example is utilities that are subject to cost-of-service regulation are given added incentives to increase the efficiency of troubled electric-generating units.

  2. State and federal regulation of OTEC plants in Hawaii

    SciTech Connect (OSTI)

    Keith, K.M.

    1980-09-01

    The advantages of ocean thermal energy conversion (OTEC) for Hawaii, its institutional support, projected contributions of OTEC in the future, and environmental concerns are discussed. Three experimental OTEC facilities in Hawaii are described, and the many regulations that must be observed and permits needed are described. Applicability of existing federal laws in regulating commercial-scale OTEC plants is examined, and applicable Coast Guard regulations and maritime laws are discussed briefly. Questions of state-federal relations, particularly regarding Hawaii's archipelagic claims and coastal zone, are addressed. (LEW)

  3. Enforcement Regulations and Directives - Worker Safety and Health |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Worker Safety and Health Enforcement Regulations and Directives - Worker Safety and Health Regulations 10 C.F.R. Part 851 - Worker Safety and Health Program; Final Rule 10 C.F.R. Part 850 - Chronic Beryllium Disease Prevention Program; Final Rule 29 C.F.R. Part 1910 - Occupational Safety and Health Standards (OSHA) 29 C.F.R. Part 1926 - Safety and Health Regulations for Construction (OSHA) 29 C.F.R. Part 1904 - Reporting and Reporting Occupational Injuries and Illnesses

  4. Industry Self-Regulation as a Means to Promote Nonproliferation

    SciTech Connect (OSTI)

    Hund, Gretchen; Elkhamri, Oksana O.

    2005-10-01

    Companies within numerous industries that have been “early adopters” of self-regulation concept, considering the environment and society alongside business issues, have realized several benefits and some competitive advantage while substantially improving their environmental performance. Given that proliferation prevention is also a public good, our premise is that the experience gained and lessons learned from the self-regulation initiative in other industries and more broadly in the arena of sustainable development provide a basis for examining the feasibility of developing self-regulation mechanisms applicable to industries involved with sensitive technologies (nuclear, radiological source, and other dual-use industries)

  5. Environmental regulation of coal mining, SMCRA`s second decade

    SciTech Connect (OSTI)

    McElfish, J.M.; Beier, A.E.

    1990-12-31

    This controversial book examines environmental regulation of coal mining in the United States over the 1979-1989 period. The Surface Mining Control and Reclamation Act of 1977 (SMCRA) established federal regulation of the environmental effects of coal mining. The permanent regulatory program implementing SMCRA was initiated in 1979. This book looks at the first ten years of SMCRA, seeking to draw lessons from experience that will improve regulation, so that the objectives of the law may be achieved in SMCRA`s second decade.

  6. Environmental Regulation of the Nuclear Industry in England and Wales in an era of Restructuring and Accelerated Decommissioning

    SciTech Connect (OSTI)

    Parker, I.W.; Weedon, C. J.

    2006-07-01

    In 2005 a large part of the UK Nuclear Industry was restructured with a new national body, the Nuclear Decommissioning Authority (NDA), being responsible for all the assets and liabilities of the nationally owned reactors and fuel cycle facilities. The former owners are now operating and in many cases decommissioning the facilities under contract to the NDA. As the body responsible for enforcing most environmental legislation in England and Wales, the Environment Agency has reviewed its regulatory approach to the Industry. This is to ensure that our responsibility to protect and enhance the environment is met whilst considering appropriately other key drivers impacting on all sectors of environmental regulation. Factors influencing this review include: - Greater public interest and concern over nuclear issues; - Greater transparency of strategies, plans and decisions in the nuclear industry; - The need to ensure that sustainable protection of the environment remains a constant feature of environmental regulation; - The need for a proportionate approach to regulation in the non-prescriptive UK legislative system; - Being effective and efficient in a period when all types of regulation are under Government and public scrutiny; - The aim of the NDA to achieve safe, secure, cost-effective, accelerated and environmentally responsible decommissioning and clean up in part by competing the management of the facilities. This has involved - Constructive liaison with the NDA both before and after its commencement to ensure we are both aware of each other's concerns; - Taking a strong influencing role at strategic and operational levels; - Putting in position arrangements for our involvement in the competitive process; - Liaison at an early stage with the industry's plans for future work; - Establishing greater clarity in our strategy and plans, notably with re-examination of the requirements of our authorisations and permits; - Establishing a new assessment resource (the Nuclear Waste Assessment Team, NWAT) to enable us to examine proposals for waste management while awaiting the establishment of a national strategy; - Seeking the modernising of legislation and exerting pressure on UK government for relevant legislative/policy changes; - Improved links to safety and security regulators; - Developing our own Environmental Assessment Principles to assist regulators and the industry on the issues to be addressed; - Speeding up, where possible, our processes for determination of applications and transfers of authorisations, to allow industry restructuring. The position is dynamic and we continue to work with Industry, the NDA and other regulators to ensure we meet our respective goals. (authors)

  7. Activation of 200 MW refusegenerated CHP upward regulation effect...

    Open Energy Info (EERE)

    EU Smart Grid Projects Map1 Overview Waste CHP plants can be used in the electricity market for upward regulation by bypassing the steam turbine. The technical design for this...

  8. Y-12 and emerging environmental regulations in 1985

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    emerging environmental regulations in 1985 In Y-12's early days of its first mission, to separate Uranium 235 from natural uranium, the peak population hit 22,482 on August 21,...

  9. Title 14 CCR, Division 2, Chapter 4 - Development, Regulation...

    Open Energy Info (EERE)

    4 CCR, Division 2, Chapter 4 - Development, Regulation, and Conservation of Oil and Gas Resources Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  10. Structural Insight into the Regulation of the SNARE Assembly...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insight into the Regulation of the SNARE Assembly by the Cell Polarity Protein Sro7 The cells that comprise many tissues are polarized, meaning that they have distinct 'sides' with...

  11. Ligand-specific regulation of the extracellular surface of a...

    Office of Scientific and Technical Information (OSTI)

    surface of a G-protein-coupled receptor Citation Details In-Document Search Title: Ligand-specific regulation of the extracellular surface of a G-protein-coupled ...

  12. Microsoft PowerPoint - Regulating Energy Commodities.ppt [Compatibilit...

    U.S. Energy Information Administration (EIA) Indexed Site

    Deanna Newcomb, MWE Regulatory & Compliance Analyst g y p y April 6, 2010 Where do you ... have a Compliance Program, do a review. y p g , The regulators are going to ask - What ...

  13. OAR 632-020 - Geothermal Regulations | Open Energy Information

    Open Energy Info (EERE)

    - Geothermal RegulationsLegal Published NA Year Signed or Took Effect 1972 Legal Citation OAR 632-020 (1972) DOI Not Provided Check for DOI availability: http:crossref.org...

  14. Staff Listing - Office of Regulation and International Engagement...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DC 20585 Director of the Office of Regulation and International Engagement John A. Anderson, Director Room 3E-052 Telephone (202) 586-0521 FAX (202) 586-6050 Division of...

  15. Groundwater Quantity Regulation in Vermont: A Path Forward |...

    Open Energy Info (EERE)

    Groundwater Quantity Regulation in Vermont: A Path Forward Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- Secondary Legal SourceSecondary Legal...

  16. Issues in federal preemption of state appliance energy efficiency regulations

    SciTech Connect (OSTI)

    Fang, J.M.; Balistocky, S.; Schaefler, A.M.

    1982-12-01

    The findings and conclusions of the analysis of the various issues involved in the federal preemption of state regulations for the DOE no standard rule on covered appliances are summarized. The covered products are: refrigerators, refrigerator-freezers, freezers, clothes dryers, kitchen ranges and ovens, water heaters (excluding heat pump water heaters), room air conditioners, central air conditioners (excluding heat pumps), and furnaces. A detailed discussion of the rationale for the positions of groups offering comment for the record is presneted. The pertinent categories of state and local regulations and programs are explained, then detailed analysis is conducted on the covered products and regulations. Issues relating to the timing of preemption of state regulations are discussed, as well as issues relating to burden of proof, contents of petitions for exemptions from preemption, criteria for evaluating petitions, and procedural and other issues. (LEW)

  17. Rules and Regulations for the Management and Control of Designated...

    Open Energy Info (EERE)

    the Management and Control of Designated Ground Water Jump to: navigation, search OpenEI Reference LibraryAdd to library Reference: Rules and Regulations for the Management and...

  18. Title 40 Code of Federal Regulations Chapter I, Subchapter C...

    Open Energy Info (EERE)

    Page Edit with form History Title 40 Code of Federal Regulations Chapter I, Subchapter C - Air Programs Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal...

  19. Cascaded'' pilot regulators help reduce LPG loss in hot weather

    SciTech Connect (OSTI)

    Not Available

    1994-08-08

    Fina Oil and Chemical Co. and Fisher Controls International used engineering resourcefulness to overcome heat-induced product loss from LPG storage bullets at Fina's Port Arthur, Tex., refinery. Fina had installed Fisher's Easy Joe 399A-6365, a pilot-operated, back-pressure-type regulator, on its LPG storage facility in 1991 as part of a fuel products modernization project. The regulators helped control the accumulation of noncondensible vapors, which collect in the storage bullets above the LPG. But summer heat extremes and surges in the tanks and lines made it possible for the operating pressure to increase so that the safety relief valve was activated before the pilot regulator was able to stabilize the pressure. The installation of pilot-type regulators, in cascaded, or series, formation, reduced product venting through relief valves.

  20. Arrangement between the Office for Nuclear Regulation of Great...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Arrangement between the Office for Nuclear Regulation of Great Britain and the United States Department of Energy for the Exchange of Information and Co-operation in the Area of ...

  1. Oak Ridge EM Program Collaborates with Regulators on Groundwater Strategy

    Broader source: Energy.gov [DOE]

    OAK RIDGE, Tenn. – The Oak Ridge EM program has joined state and federal regulators in a series of workshops to address contaminated groundwater on the Oak Ridge Reservation.

  2. Elucidating the Molecular Basis and Regulation of Chromium (VI...

    Office of Scientific and Technical Information (OSTI)

    by Shewanella oneidensis MR-1. We have identified and characterized (in the case of DNA-binding response regulator SO2426 and a putative azoreductase SO3585) the genes and ...

  3. Contacts for the Assistant General Counsel for Legislation, Regulation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Daniel Cohen, Assistant General Counsel for Legislation, Regulation, & Energy Efficiency 202-586-9523 daniel.cohen@hq.doe.gov Catherine Goshe, Attorney-Adviser 202-586-7053 Preeti ...

  4. Current and proposed regulations for salt water disposal wells

    SciTech Connect (OSTI)

    Moody, T.

    1994-09-01

    In recent years, all aspects of hydrocarbon exploration and production (E & P) activities have drawn closer scrutiny in terms of existing and potential impairment of the environment. In addition to drilling, production, and transportation activities, the USEPA has focused on the nature of E & P generated wastes, and the subsequent management of both hazardous and nonhazardous E & P wastes. Approximately 98% of all of the volume of wastes generated by E & P activities is salt water associated with the recovery of hydrocarbons. By far the majority of this waste is disposed of in class II salt water disposal wells. Due to the tremendous volume of salt water generated, the USEPA continues to reevaluate the federal class II salt water injection well program, offering comments, revising its interpretation of existing regulations, and promulgating new regulations. The purpose of the presentation will be to provide a review of existing class II federal regulations, and to provide an overview of potential or newly promulgated regulations.

  5. Current and proposed regulations for salt-water disposal wells

    SciTech Connect (OSTI)

    Moody, T.

    1994-12-31

    In recent years, all aspects of hydrocarbon exploration and production (E&P) activities have drawn closer scrutiny in terms of existing and potential impairment of the environment. In addition to drilling, production, and transportation activities, the United States Environmental Protection Agency (USEPA) has focused on the nature of E&P wastes. Approximately 98% of the volume of wastes generated by E&P activities is salt water associated with the recovery of hydrocarbons. By far the majority of this waste is reinjected in Class II wells as a nonhazardous waste. Due to the tremendous volume of salt water disposed of in Class II injection wells, the USEPA continues to reevaluate the Federal salt-water injection well program, offering comments, revising its interpretation of existing regulations, and promulgating new regulations. The purpose of this paper is to provide a review of existing Federal Class II injection well regulations and to provide an overview of potential of newly promulgated regulations.

  6. Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy PART 835-OCCUPATIONAL RADIATION PROTECTION Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION General. The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities. PDF icon Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION More Documents & Publications Order Module--NNSA OCCUPATIONAL RADIATION

  7. Comments Received on Proposed Rulemaking for regulation implementing

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    section 216(h): Coordination of Federal Transmission Permitting on Federal Lands | Department of Energy Received on Proposed Rulemaking for regulation implementing section 216(h): Coordination of Federal Transmission Permitting on Federal Lands Comments Received on Proposed Rulemaking for regulation implementing section 216(h): Coordination of Federal Transmission Permitting on Federal Lands Section 1221(a) of EPAct 2005, which added section 216(h) to the Federal Power Act, stated that the

  8. Method to determine transcriptional regulation pathways in organisms

    Office of Scientific and Technical Information (OSTI)

    (Patent) | SciTech Connect Method to determine transcriptional regulation pathways in organisms Citation Details In-Document Search Title: Method to determine transcriptional regulation pathways in organisms × You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and is provided as a public service. Visit OSTI to utilize additional information resources in energy science and

  9. Code of Federal Regulations Nuclear Activities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Code of Federal Regulations Nuclear Activities Code of Federal Regulations Nuclear Activities April 24,2010 This part sets forth the procedures to govern the conduct of persons involved in DOE nuclear activities and, in particular, to achieve compliance with the DOE Nuclear Safety Requirements by all persons subject to those requirements. 10 C.F.R. 820, Procedural Rules for DOE Nuclear Activities, sets forth the procedures to implement the provisions of the Price-Anderson Amendments Act of 1988

  10. Collegiate Wind Competition Rules and Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Collegiate Wind Competition Rules and Regulations Collegiate Wind Competition Rules and Regulations The competition challenges interdisciplinary teams of undergraduate students from a variety of academic programs to offer unique solutions to complex wind-energy-related problems. To fulfill the requirements, each team must perform the following multifaceted tasks: Develop and deliver a market-research-supported business plan that shapes the design and development of the team's turbine and load

  11. DOE Proposes Regulations for Loan Guarantee Program | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations for Loan Guarantee Program DOE Proposes Regulations for Loan Guarantee Program May 10, 2007 - 12:45pm Addthis Program to spur clean, innovative energy technologies WASHINGTON, DC - The U.S. Department of Energy (DOE) today issued a Notice of Proposed Rulemaking (NOPR) for its Loan Guarantee program, which will help spur investment in projects that employ new, clean energy technologies. Projects within DOE's Loan Guarantee program will help sustain economic growth, yield environmental

  12. QB1 - Stochastic Gene Regulation (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Conference: QB1 - Stochastic Gene Regulation Citation Details In-Document Search Title: QB1 - Stochastic Gene Regulation Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present in the cell - Random motion and competition between reactants, Low copy, quantization of reactants, Upstream processes; (2) Fluctuations may be very important - Cell-to-cell variability, Cell fate decisions (switches), Signal amplification or damping, stochastic resonances; and (3) Some tools

  13. RNA-guided transcriptional regulation (Patent) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Patent: RNA-guided transcriptional regulation Citation Details In-Document Search Title: RNA-guided transcriptional regulation Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided

  14. New methods for tightly regulated gene expression and highly efficient

    Office of Scientific and Technical Information (OSTI)

    chromosomal integration of cloned genes for Methanosarcina species (Journal Article) | SciTech Connect New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species Citation Details In-Document Search Title: New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species A highly efficient method for chromosomal integration of cloned DNA into

  15. Regulations.gov - Proposed Rule Document | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations.gov - Proposed Rule Document Regulations.gov - Proposed Rule Document In response to your phone call and e-mail below the proposed rule that you reference below regarding energy efficiency standards for manufactured housing has not been issued yet by the Department of Energy (DOE) and therefore we are still in the process of drafting a proposed rule and any necessary definitions. PDF icon Proposed Rule Email More Documents & Publications ISSUANCE 2015-02-04: Energy Conservation

  16. Department of Energy Acquisition Regulation (DEAR) Subpart 903.9:

    Energy Savers [EERE]

    Whistleblower Protections for Contractor Employees | Department of Energy Department of Energy Acquisition Regulation (DEAR) Subpart 903.9: Whistleblower Protections for Contractor Employees Department of Energy Acquisition Regulation (DEAR) Subpart 903.9: Whistleblower Protections for Contractor Employees Stakeholders: DOE Contractor employees Scope: This subpart of DEAR implements the DOE Contractor Employee Protection Program as set forth at 10 CFR part 708. This establishes the criteria

  17. Medical and biofuel advances possible with new gene regulation tool

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Medical and biofuel advances possible with new gene regulation tool Medical and biofuel advances possible with new gene regulation tool The key is a tunable switch made from a small non-coding RNA molecule that could have value for medical and even biofuel production purposes. August 20, 2015 Scientists at Los Alamos National Laboratory have manufactured molecular "dimmer" switches to control cellular metabolism with exquisite precision. The research has potential widespread

  18. NNSA Updates Export Control Regulation | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration Updates Export Control Regulation February 24, 2015 WASHINGTON, D.C. - The National Nuclear Security Administration (NNSA) updated the Federal rule (10 CFR Part 810, or Part 810) that regulates the export of unclassified nuclear technology and assistance. The final rule was published in the Federal Register on Feb. 23 and will go into effect on March 25, 2015. Part 810 enables civil nuclear trade by ensuring that nuclear technology and assistance exported from the United

  19. Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Subpart A - General Provisions | Department of Energy PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A - General Provisions Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A - General Provisions The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities. PDF icon Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION

  20. Synthesis of segmented silica rods by growth temperature regulation

    Office of Scientific and Technical Information (OSTI)

    (Journal Article) | SciTech Connect segmented silica rods by growth temperature regulation Citation Details In-Document Search Title: Synthesis of segmented silica rods by growth temperature regulation Authors: Sharma, Jaswinder K [1] ; Datskos, Panos G [1] + Show Author Affiliations ORNL Publication Date: 2014-01-01 OSTI Identifier: 1115377 DOE Contract Number: DE-AC05-00OR22725 Resource Type: Journal Article Resource Relation: Journal Name: Angewandte Chemie International Edition; Journal

  1. A Simpler, Smarter and More Cost Effective Approach to Regulation |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy A Simpler, Smarter and More Cost Effective Approach to Regulation A Simpler, Smarter and More Cost Effective Approach to Regulation May 26, 2011 - 9:17am Addthis Sean Lev Sean Lev Acting General Counsel & Deputy General Counsel, Environment & Nuclear Programs What does this mean for me? The Department projects a more than 90% reduction in the paperwork burden imposed on recipients of the Department of Energy's financial assistance. The Department is also working

  2. California Regulations on Renewble Hydrogen and Low Carbon Technologies |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Regulations on Renewble Hydrogen and Low Carbon Technologies California Regulations on Renewble Hydrogen and Low Carbon Technologies Presentation at the Renewable Hydrogen Workshop, Nov. 16, 2009, in Palm Springs, CA PDF icon renewable_hydrogen_workshop_nov16_achtelik.pdf More Documents & Publications Transportation and Stationary Power Integration Workshop: A California Perspective Vision for Rollout of Fuel Cell Vehicles and Hydrogen Fuel Stations State of the

  3. Compensated gain control circuit for buck regulator command charge circuit

    DOE Patents [OSTI]

    Barrett, David M.

    1996-01-01

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit.

  4. Compensated gain control circuit for buck regulator command charge circuit

    DOE Patents [OSTI]

    Barrett, D.M.

    1996-11-05

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit. 5 figs.

  5. Rab proteins: The key regulators of intracellular vesicle transport

    SciTech Connect (OSTI)

    Bhuin, Tanmay; Roy, Jagat Kumar

    2014-10-15

    Vesicular/membrane trafficking essentially regulates the compartmentalization and abundance of proteins within the cells and contributes in many signalling pathways. This membrane transport in eukaryotic cells is a complex process regulated by a large and diverse array of proteins. A large group of monomeric small GTPases; the Rabs are essential components of this membrane trafficking route. Most of the Rabs are ubiquitously expressed proteins and have been implicated in vesicle formation, vesicle motility/delivery along cytoskeleton elements and docking/fusion at target membranes through the recruitment of effectors. Functional impairments of Rabs affecting transport pathways manifest different diseases. Rab functions are accompanied by cyclical activation and inactivation of GTP-bound and GDP-bound forms between the cytosol and membranes which is regulated by upstream regulators. Rab proteins are characterized by their distinct sub-cellular localization and regulate a wide variety of endocytic, transcytic and exocytic transport pathways. Mutations of Rabs affect cell growth, motility and other biological processes. - Highlights: Rab proteins regulate different signalling pathways. Deregulation of Rabs is the fundamental causes of a variety of human diseases. This paper gives potential directions in developing therapeutic targets. This paper also gives ample directions for modulating pathways central to normal physiology. These are the huge challenges for drug discovery and delivery in near future.

  6. Hazardous waste identification: A guide to changing regulations

    SciTech Connect (OSTI)

    Stults, R.G. )

    1993-03-01

    The Resource Conservation and Recovery Act (RCRA) was enacting in 1976 and amended in 1984 by the Hazardous and Solid Waste Amendments (HSWA). Since then, federal regulations have generated a profusion of terms to identify and describe hazardous wastes. Regulations that5 define and govern management of hazardous wastes are codified in Title 40 of the code of Federal Regulations, Protection of the environment''. Title 40 regulations are divided into chapters, subchapters and parts. To be defined as hazardous, a waste must satisfy the definition of solid waste any discharged material not specifically excluded from regulation or granted a regulatory variance by the EPA Administrator. Some wastes and other materials have been identified as non-hazardous and are listed in 40 CFR 261.4(a) and 261.4(b). Certain wastes that satisfy the definition of hazardous waste nevertheless are excluded from regulation as hazardous if they meet specific criteria. Definitions and criteria for their exclusion are found in 40 CFR 261.4(c)-(f) and 40 CFR 261.5.

  7. Consumer attitudes toward potentially restrictive energy conservation regulations

    SciTech Connect (OSTI)

    Merfeld, M.K.

    1984-01-01

    A sample of 893 Oregon individuals from a Western Regional Agricultural Experiment Station Project (W-159 Consequences of Energy Conservation Policies for Western Region Households) was used to analyze consumer attitudes toward potentially restrictive energy conservation regulations. Belief in the seriousness of the energy problem, a psychological measure of internal control (internality), and eight socio-demographic characteristics were examined in relation to consumer attitudes toward these regulations. Those who did not believe in the seriousness of the energy problem were over 50 years of age, male, had less than a college degree, and opposed mandatory energy conservation regulations related to home thermostat settings. Homeowners opposed the regulation requiring their homes to pass an energy audit. Opposition to regulations appeared to be related only to an individual's perception of the consequences of the regulation, and not to belief in the enregy problem or locus of control. Those with low internality scores included females, rural residents, respondents over 50, and those with less than a college degree.

  8. This Week In Petroleum Printer-Friendly Version

    Gasoline and Diesel Fuel Update (EIA)

    after the final out in the 2006 World Series is recorded. Residential Heating Oil and Propane Prices Remain Relatively Unchanged Residential heating oil prices increased very...

  9. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... (IA) (United States) USDOE Office of Management and Administration (United States) ... Importantly, the behavior of the devices remained unchanged under varying bending ...

  10. Extracellular calmodulin regulates growth and cAMP-mediated chemotaxis in Dictyostelium discoideum

    SciTech Connect (OSTI)

    O'Day, Danton H.; Huber, Robert J.; Suarez, Andres

    2012-09-07

    Highlights: Black-Right-Pointing-Pointer Extracellular calmodulin is present throughout growth and development in Dictyostelium. Black-Right-Pointing-Pointer Extracellular calmodulin localizes within the ECM during development. Black-Right-Pointing-Pointer Extracellular calmodulin inhibits cell proliferation and increases chemotaxis. Black-Right-Pointing-Pointer Extracellular calmodulin exists in eukaryotic microbes. Black-Right-Pointing-Pointer Extracellular calmodulin may be functionally as important as intracellular calmodulin. -- Abstract: The existence of extracellular calmodulin (CaM) has had a long and controversial history. CaM is a ubiquitous calcium-binding protein that has been found in every eukaryotic cell system. Calcium-free apo-CaM and Ca{sup 2+}/CaM exert their effects by binding to and regulating the activity of CaM-binding proteins (CaMBPs). Most of the research done to date on CaM and its CaMBPs has focused on their intracellular functions. The presence of extracellular CaM is well established in a number of plants where it functions in proliferation, cell wall regeneration, gene regulation and germination. While CaM has been detected extracellularly in several animal species, including frog, rat, rabbit and human, its extracellular localization and functions are less well established. In contrast the study of extracellular CaM in eukaryotic microbes remains to be done. Here we show that CaM is constitutively expressed and secreted throughout asexual development in Dictyostelium where the presence of extracellular CaM dose-dependently inhibits cell proliferation but increases cAMP mediated chemotaxis. During development, extracellular CaM localizes within the slime sheath where it coexists with at least one CaMBP, the matricellular CaM-binding protein CyrA. Coupled with previous research, this work provides direct evidence for the existence of extracellular CaM in the Dictyostelium and provides insight into its functions in this model amoebozoan.

  11. Discoidin domain receptor 2 (DDR2) regulates proliferation of endochondral cells in mice

    SciTech Connect (OSTI)

    Kawai, Ikuma; Hisaki, Tomoka; Sugiura, Koji; Naito, Kunihiko; Kano, Kiyoshi; Biomedical Science Center for Translational Research , The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515

    2012-10-26

    Highlights: Black-Right-Pointing-Pointer Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase. Black-Right-Pointing-Pointer DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. Black-Right-Pointing-Pointer We produced in vitro and in vivo model to better understand the role of DDR2. Black-Right-Pointing-Pointer DDR2 might play an inhibitory role in the proliferation of chondrocyte. -- Abstract: Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in murine preosteoblastic cells, but the functions of DDR2 in chondrogenic cellular proliferation remain unclear. To better understand the role of DDR2 signaling in cellular proliferation in endochondral ossification, we inhibited Ddr2 expression via the inhibitory effect of miRNA on Ddr2 mRNA (miDdr2) and analyzed the cellular proliferation and differentiation in the prechondrocyte ATDC5 cell lines. To investigate DDR2's molecular role in endochondral cellular proliferation in vivo, we also produced transgenic mice in which the expression of truncated, kinase dead (KD) DDR2 protein is induced, and evaluated the DDR2 function in cellular proliferation in chondrocytes. Although the miDdr2-transfected ATDC5 cell lines retained normal differentiation ability, DDR2 reduction finally promoted cellular proliferation in proportion to the decreasing ratio of Ddr2 expression, and it also promoted earlier differentiation to cartilage cells by insulin induction. The layer of hypertrophic chondrocytes in KD Ddr2 transgenic mice was not significantly thicker than that of normal littermates, but the layer of proliferative chondrocytes in KD-Ddr2 transgenic mice was significantly thicker than that of normal littermates. Taken together, our data demonstrated that DDR2 might play a local and essential role in the proliferation of chondrocytes.

  12. O.A.R. 340-045 - Regulations Pertaining to NPDES and WPCF Permits...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: O.A.R. 340-045 - Regulations Pertaining to NPDES and WPCF PermitsLegal Abstract These...

  13. NMAC 1.2.2 Public Regulations Commission Rules of Procedure ...

    Open Energy Info (EERE)

    NMAC 1.2.2 Public Regulations Commission Rules of Procedure Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: NMAC 1.2.2...

  14. 1 NMAC 2.2 - Public Regulation Commission Rules of Procedure...

    Open Energy Info (EERE)

    NMAC 2.2 - Public Regulation Commission Rules of Procedure Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 1 NMAC 2.2 -...

  15. Code of Colorado Regulations 2 CCR 601-1, State Highway Access...

    Open Energy Info (EERE)

    Code of Colorado Regulations 2 CCR 601-1, State Highway Access Code Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Code of...

  16. Colorado Code of Regulations 2 CCR 601-18, State Utility Accommodation...

    Open Energy Info (EERE)

    Colorado Code of Regulations 2 CCR 601-18, State Utility Accommodation Code Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation:...

  17. WAC 332-17 Geothermal Drilling Rules and Regulations | Open Energy...

    Open Energy Info (EERE)

    17 Geothermal Drilling Rules and Regulations Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC 332-17 Geothermal Drilling...

  18. Colorado 4 CCR 723-3001, Definitions for Rules Regulating Electric...

    Open Energy Info (EERE)

    4 CCR 723-3001, Definitions for Rules Regulating Electric Utilities Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation:...

  19. 4 Code of Colorado Regulations (CCR) 723-3 | Open Energy Information

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: 4 Code of Colorado Regulations (CCR) 723-3Legal Abstract Colorado Public Utilities...

  20. H.A.R. 13-171 - Designation and Regulation of Water Management...

    Open Energy Info (EERE)

    search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: H.A.R. 13-171 - Designation and Regulation of Water Management AreasLegal Published NA Year...

  1. Prediction of epigenetically regulated genes in breast cancer cell lines

    SciTech Connect (OSTI)

    Loss, Leandro A; Sadanandam, Anguraj; Durinck, Steffen; Nautiyal, Shivani; Flaucher, Diane; Carlton, Victoria EH; Moorhead, Martin; Lu, Yontao; Gray, Joe W; Faham, Malek; Spellman, Paul; Parvin, Bahram

    2010-05-04

    Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation of CpG islands may silence associated genes. Therefore, using high-throughput microarrays to measure CpG island methylation will lead to better understanding of tumor pathobiology and progression, while revealing potentially new biomarkers. We have examined a recently developed high-throughput technology for measuring genome-wide methylation patterns called mTACL. Here, we propose a computational pipeline for integrating gene expression and CpG island methylation profles to identify epigenetically regulated genes for a panel of 45 breast cancer cell lines, which is widely used in the Integrative Cancer Biology Program (ICBP). The pipeline (i) reduces the dimensionality of the methylation data, (ii) associates the reduced methylation data with gene expression data, and (iii) ranks methylation-expression associations according to their epigenetic regulation. Dimensionality reduction is performed in two steps: (i) methylation sites are grouped across the genome to identify regions of interest, and (ii) methylation profles are clustered within each region. Associations between the clustered methylation and the gene expression data sets generate candidate matches within a fxed neighborhood around each gene. Finally, the methylation-expression associations are ranked through a logistic regression, and their significance is quantified through permutation analysis. Our two-step dimensionality reduction compressed 90% of the original data, reducing 137,688 methylation sites to 14,505 clusters. Methylation-expression associations produced 18,312 correspondences, which were used to further analyze epigenetic regulation. Logistic regression was used to identify 58 genes from these correspondences that showed a statistically signifcant negative correlation between methylation profles and gene expression in the panel of breast cancer cell lines. Subnetwork enrichment of these genes has identifed 35 common regulators with 6 or more predicted markers. In addition to identifying epigenetically regulated genes, we show evidence of differentially expressed methylation patterns between the basal and luminal subtypes. Our results indicate that the proposed computational protocol is a viable platform for identifying epigenetically regulated genes. Our protocol has generated a list of predictors including COL1A2, TOP2A, TFF1, and VAV3, genes whose key roles in epigenetic regulation is documented in the literature. Subnetwork enrichment of these predicted markers further suggests that epigenetic regulation of individual genes occurs in a coordinated fashion and through common regulators.

  2. Implications of Carbon Regulation for Green Power Markets

    SciTech Connect (OSTI)

    Bird, Lori; Holt, Ed; Carroll, Ghita

    2007-04-01

    This paper examines the potential effects that emerging mandatory carbon markets have for voluntary markets for renewable energy, or green power markets. In an era of carbon regulation, green power markets will continue to play an important role because many consumers may be interested in supporting renewable energy development beyond what is supported through mandates or other types of policy support. The paper examines the extent to which GHG benefits motivate consumers to make voluntary renewable energy purchases and summarizes key issues emerging as a result of these overlapping markets, such as the implications of carbon regulation for renewable energy marketing claims, the demand for and price of renewable energy certificates (RECs), and the use of RECs in multiple markets (disaggregation of attributes). It describes carbon regulation programs under development in the Northeast and California, and how these might affect renewable energy markets in these regions, as well as the potential interaction between voluntary renewable energy markets and voluntary carbon markets, such as the Chicago Climate Exchange (CCX). It also briefly summarizes the experience in the European Union, where carbon is already regulated. Finally, the paper presents policy options for policymakers and regulators to consider in designing carbon policies to enable carbon markets and voluntary renewable energy markets to work together.

  3. Environmental regulations and changes in petroleum refining operations

    SciTech Connect (OSTI)

    Lidderdale, T.C.M.

    1996-03-01

    The U.S. petroleum industry has responded to four major new federal rules on motor gasoline product quality in the last 6 years: Phase 1 Summer Volatility (Rvp) Regulation, June 1989; Phase 2 Summer Volatility (Rvp) regulation, May 1992; oxygenated Gasoline, November 1992; and reformulated Gasoline Phase I Simple Model, December 1994. These regulations have generated significant changes in domestic refinery operations, affecting marginal production costs and market prices, refinery yields, and the seasonality of production. Some changes have been dramatic. The price of motor gasoline has increased by as much as 60 {cents}/gal due to regulations. Refinery yields of motor gasoline (refinery output of motor gasoline as a fraction of refinery inputs or total refinery output), which historically peaked in the early summer to meet high summer driving demand, now are highest during the winter months. These changes in domestic refining operations are identified and related to the vapor pressure, oxygenated and reformulated gasoline (RFG) product quality regulations. This analysis uses linear regression equations from the Energy Information Administration`s (EIA) Short-Term Integrated Forecasting System (STIFS). The STIFS model is used for producing forecasts appearing in the EIA`s Short-Term Energy Outlook.

  4. Air-flow regulation system for a coal gasifier

    DOE Patents [OSTI]

    Fasching, George E.

    1984-01-01

    An improved air-flow regulator for a fixed-bed coal gasifier is provided which allows close air-flow regulation from a compressor source even though the pressure variations are too rapid for a single primary control loop to respond. The improved system includes a primary controller to control a valve in the main (large) air supply line to regulate large slow changes in flow. A secondary controller is used to control a smaller, faster acting valve in a secondary (small) air supply line parallel to the main line valve to regulate rapid cyclic deviations in air flow. A low-pass filter with a time constant of from 20 to 50 seconds couples the output of the secondary controller to the input of the primary controller so that the primary controller only responds to slow changes in the air-flow rate, the faster, cyclic deviations in flow rate sensed and corrected by the secondary controller loop do not reach the primary controller due to the high frequency rejection provided by the filter. This control arrangement provides at least a factor of 5 improvement in air-flow regulation for a coal gasifier in which air is supplied by a reciprocating compressor through a surge tank.

  5. JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells

    SciTech Connect (OSTI)

    Das, Amitabh; Chai, Jin Choul; Jung, Kyoung Hwa; Das, Nando Dulal; Kang, Sung Chul; Lee, Young Seek; Seo, Hyemyung; Chai, Young Gyu

    2014-11-01

    JMJD2A is a lysine trimethyl-specific histone demethylase that is highly expressed in a variety of tumours. The role of JMJD2A in tumour progression remains unclear. The objectives of this study were to identify JMJD2A-regulated genes and understand the function of JMJD2A in p53-null neuroectodermal stem cells (p53{sup −/−} NE-4Cs). We determined the effect of LPS as a model of inflammation in p53{sup −/−} NE-4Cs and investigated whether the epigenetic modifier JMJD2A alter the expression of tumourigenic inflammatory genes. Global gene expression was measured in JMJD2A knockdown (kd) p53{sup −/−} NE-4Cs and in LPS-stimulated JMJD2A-kd p53{sup −/−} NE-4C cells. JMJD2A attenuation significantly down-regulated genes were Cdca2, Ccnd2, Ccnd1, Crebbp, IL6rα, and Stat3 related with cell cycle, proliferation, and inflammatory-disease responses. Importantly, some tumour-suppressor genes including Dapk3, Timp2 and TFPI were significantly up-regulated but were not affected by silencing of the JMJD2B. Furthermore, we confirmed the attenuation of JMJD2A also down-regulated Cdca2, Ccnd2, Crebbp, and Rest in primary NSCs isolated from the forebrains of E15 embryos of C57/BL6J mice with effective p53 inhibitor pifithrin-α (PFT-α). Transcription factor (TF) motif analysis revealed known binding patterns for CDC5, MYC, and CREB, as well as three novel motifs in JMJD2A-regulated genes. IPA established molecular networks. The molecular network signatures and functional gene-expression profiling data from this study warrants further investigation as an effective therapeutic target, and studies to elucidate the molecular mechanism of JMJD2A-kd-dependent effects in neuroectodermal stem cells should be performed. - Highlights: • Significant up-regulation of epigenetic modifier JMJD2A mRNA upon LPS treatment. • Inhibition of JMJD2A attenuated key inflammatory and tumourigenic genes. • Establishing IPA based functional genomics in JMJD2A-attenuated p53{sup −/−} NE4C cells. • Finding JMJD2A-based molecular targets and crucial pathways in p53{sup −/−} NE4C cells.

  6. Ion-acoustic shocks with self-regulated ion reflection and acceleratio...

    Office of Scientific and Technical Information (OSTI)

    Ion-acoustic shocks with self-regulated ion reflection and acceleration Citation Details ... Title: Ion-acoustic shocks with self-regulated ion reflection and acceleration Authors: ...

  7. Montana Rule 36.25.4 Geothermal Rules and Regulations | Open...

    Open Energy Info (EERE)

    Geothermal Rules and RegulationsLegal Abstract Montana regulation governing administration of geothermal resources in the state. Published NA Year Signed or Took Effect...

  8. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    SciTech Connect (OSTI)

    Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong

    2013-04-05

    Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  9. Feedback regulated induction heater for a flowing fluid

    DOE Patents [OSTI]

    Migliori, A.; Swift, G.W.

    1984-06-13

    A regulated induction heater for heating a stream of flowing fluid to a predetermined desired temperature. The heater includes a radiofrequency induction coil which surrounds a glass tube through which the fluid flows. A heating element consisting of a bundle of approximately 200 stainless steel capillary tubes located within the glass tube couples the output of the induction coil to the fluid. The temperature of the fluid downstream from the heating element is sensed with a platinum resistance thermometer, the output of which is applied to an adjustable porportional and integral feedback control circuit which regulates the power applied to the induction coil. The heater regulates the fluid temperature to within 0.005/sup 0/C at a flow rate of 50 cm/sup 3//sec with a response time of less than 0.1 second, and can accommodate changes in heat load up to 1500 watts.

  10. Feedback regulated induction heater for a flowing fluid

    DOE Patents [OSTI]

    Migliori, Albert; Swift, Gregory W.

    1985-01-01

    A regulated induction heater for heating a stream of flowing fluid to a predetermined desired temperature. The heater includes a radiofrequency induction coil which surrounds a glass tube through which the fluid flows. A heating element consisting of a bundle of approximately 200 stainless steel capillary tubes located within the glass tube couples the output of the induction coil to the fluid. The temperature of the fluid downstream from the heating element is sensed with a platinum resistance thermometer, the output of which is applied to an adjustable proportional and integral feedback control circuit which regulates the power applied to the induction coil. The heater regulates the fluid temperature to within 0.005.degree. C. at a flow rate of 50 cm.sup.3 /second with a response time of less than 0.1 second, and can accommodate changes in heat load up to 1500 watts.

  11. MTBreg: The Database of Conditionally Regulated Proteins in Mycobacterium Tuberculosis

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kaufman, Markus; Pal, Debnath; Eisenberg, David

    Proteins up- and down- regulated in Mycobacterium tuberculosis grown under conditions mimicking infection are included in this database. It also includes information on proteins that are regulated by selected transcription factors or other regulatory proteins. The literature data provided here is complimentary to the databases provided by Michael Strong that include recent TB computational functional linkages and the Prolinks Database by Peter Bowers. The experimental condition, the experimental dataset and a literature reference will be displayed, including links to the computationally linked proteins in the Prolinks Database and the entry in the Mycobacterium tuberculosis Structural Genomics Database.[Copied from information at http://www.doe-mbi.ucla.edu/Services/MTBreg/

  12. Will regulation impede the market for emissions allowances

    SciTech Connect (OSTI)

    Anderson, B.S.; Casey, W.T.

    1994-03-15

    Title IV of the Clean Air Act Amendments of 1990 allow for trading of allowances for SO[sub 2] emissions. For this process to be efficient and to achieve the goal of reducing emissions by 10 million tons from 1980 levels, a freely functioning market in allowance trading needs to exist. This market could be threatened by some state regulations that require utilities to obtain prior approval from state commissions before selling property. There are several solutions for state regulators to employ to avoid inadvertently interfering with the allowance trading market. This article describes some of those possible solutions.

  13. Emission Regulations Reduced Impact of Climate Change in CA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Emission Regulations Reduced Impact of Climate Change in CA Emission Regulations Reduced Impact of Climate Change in CA Study shows clean diesel programs slashed black carbon, a powerful short-term contributor to global warming June 13, 2013 Jon Weiner 510-486-4014 jrweiner@lbl.gov CA-BC-graphic.jpg Sacramento - Reductions in emissions of black carbon since the late 1980s, mostly from diesel engines as a result of air quality programs, have resulted in a measurable reduction of concentrations of

  14. DOE - Office of Legacy Management -- Minneapolis-Honeywell Regulator Co -

    Office of Legacy Management (LM)

    PA 30 Minneapolis-Honeywell Regulator Co - PA 30 FUSRAP Considered Sites Site: MINNEAPOLIS-HONEYWELL REGULATOR CO (PA.30 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: Brown Instrument Division PA.30-1 Location: Wayne and Roberts Avenue , Philadelphia , Pennsylvania PA.30-2 Evaluation Year: 1987 PA.30-3 Site Operations: Research/Development and Testing - small-scale thermal conductivity test on uranium rods - early 1950s. PA.30-1 PA.30-2

  15. Multi-Pollutant Legislation and Regulations (released in AEO2005)

    Reports and Publications (EIA)

    2005-01-01

    The 108th Congress proposed and debated a variety of bills addressing pollution control at electric power plants but did not pass any of them into law. In addition, the Environmental Protection Agency (EPA) currently is preparing two regulations-a proposed Clean Air Interstate Rule (pCAIR) and a Clean Air Mercury Rule (CAMR)-to address emissions from coal-fired power plants. Several states also have taken legislative actions to limit pollutants from power plants in their jurisdictions. This section discusses three Congressional air pollution bills and the EPA's pCAIR and CAMR regulations.

  16. Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1

    SciTech Connect (OSTI)

    Popko-Scibor, Anita E.; Lindberg, Mikael J.; Hansson, Magnus L.; Holmlund, Teresa; Wallberg, Annika E.

    2011-12-16

    Highlights: Black-Right-Pointing-Pointer p300 acetylates conserved lysines within Notch1 C-terminal nuclear localization signal. Black-Right-Pointing-Pointer MAML1 and CSL, components of Notch transcription complex, increase Notch acetylation. Black-Right-Pointing-Pointer MAML1-dependent acetylation of Notch1 by p300 decreases the ubiquitination of Notch1. Black-Right-Pointing-Pointer CDK8 inhibits Notch acetylation and Notch transcription enhanced by p300. -- Abstract: Earlier studies demonstrated the involvement of the p300 histone acetyltransferase in Notch signaling but the precise mechanisms by which p300 might modulate Notch function remains to be investigated. In this study, we show that p300 acetylates Notch1 ICD in cell culture assay and in vitro, and conserved lysines located within the Notch C-terminal nuclear localization signal are essential for Notch acetylation. MAML1 and CSL, which are components of the Notch transcription complex, enhance Notch acetylation and we suggest that MAML1 increases Notch acetylation by potentiating p300 autoacetylation. Furthermore, MAML1-dependent acetylation of Notch1 ICD by p300 decreases the ubiquitination of Notch1 ICD in cellular assays. CDK8 has been shown to target Notch1 for ubiquitination and proteosomal degradation. We show that CDK8 inhibits Notch acetylation and Notch transcription enhanced by p300. Therefore, we speculate that acetylation of Notch1 might be a mechanism to regulate Notch activity by interfering with ubiquitin-dependent pathways.

  17. Harmonization - Two Years' of Transportation Regulation Lessons Learned

    SciTech Connect (OSTI)

    Colborn, K.

    2007-07-01

    The U.S. Department of Transportation issued modifications to the Hazardous Materials Regulations in October, 2004 as part of an ongoing effort to 'harmonize' U.S. regulations with those of the International Atomic Energy Agency. The harmonization effort had several predictable effects on low level radioactive materials shipment that were anticipated even prior to their implementation. However, after two years' experience with the new regulations, transporters have identified several effects on transportation which were not entirely apparent when the regulations were first implemented. This paper presents several case studies in the transportation of low level radioactive materials since the harmonization rules took effect. In each case, an analysis of the challenge posed by the regulatory revision is provided. In some cases, more than one strategy for compliance was considered, and the advantages and disadvantages of each are discussed. In several cases, regulatory interpretations were sought and obtained, and these are presented to clarify the legitimacy of the compliance approach. The presentation of interpretations will be accompanied by reports of clarifying discussions with the U.S. DOT about the interpretation and scope of the regulatory change. Specific transportation issues raised by the revised hazardous materials regulations are reviewed, including: The new definition of radioactive material in accordance with isotope-specific concentration and total activity limits. The new hazardous materials regulations (HMR) created a new definition for radioactive material. A case study is presented for soils contaminated with low levels of Th-230. These soils had been being shipped for years as exempt material under the old 2,000 pCi/g concentration limit. Under the new HMR, these same soils were radioactive material. Further, in rail-car quantities their activity exceeded an A2 value, so shipment of the material in gondolas appeared to require an IP-2 package. Interpretations, discussions, and an exemption were obtained to secure the continued shipment of this material. A provision to allow 'natural' radioactive materials to be exempt from the requirements of the HMR at up to 10x the listed isotopic concentrations. The revised HMR exempts certain natural materials and ores from regulation as radioactive material at concentrations up to 10x that allowed if the materials are not natural. The term 'natural' is not well defined, and initial attempts to qualify for this exemption were thwarted by concerns over what degree of material processing, if any, materials could experience and still be considered 'natural'. The presentation includes an example from a project involving post-processed tungsten ore, and includes interpretations from the US DOT as well as clarifying language from current and drafted IAEA regulation and guidance. New packaging descriptions allowing the use of cargo containers as IP-2 and IP-3 packages in some applications. The revised HMR provides an alternate certification procedure under which standard cargo containers can be used as IP-2 and IP-3 containers. There has been some confusion about how this high level of certification can apply to standard cargo containers when other sections of the regulations make this certification available only to considerably more stout containers after rigorous testing. The discussion includes interpretive guidance from the US DOT, and from the UK Department of Transport clarifying the same provision in IAEA regulations. A new definition of contamination with apparently broad impact on the shipment of empty containers and conveyances. The revised HMR presented a definition of contamination not referenced by any other part of the HMR. The preamble to the revised HMR provides confusing guidance on the application of the definition to shipment of empty containers, and subsequent interpretive guidance letters appear to conflict with the preamble as well as with each other. The definition also has the effect of regulating materials for transport as radioactive even when US

  18. Differences in the regulation of chemicals and radionuclides

    SciTech Connect (OSTI)

    Travis, C.C.

    1993-12-01

    Government regulations limiting public exposure to radionuclides and chemicals have historically been developed by regulatory agencies using different approaches with the result that levels of protection vary for the two classes of contaminants. These differences create difficulties in determining equitable regulatory measures when both radionuclides and chemical pollutants are involved. Generally, radiation exposure is not regulated as stringently as chemical exposure (Travis et al, 1989). The International commission on Radiological Protection (ICRP) recommends limiting excess environmental radiation exposure to the general public to 100 millirem per year (mrem/yr) (ICRP, 1991), a lifetime cancer risk of about 3.5E-3. An acceptable level of risk for chemical exposures is generally considered to be below 1E-6. Differences in regulatory approach for radionuclides and chemicals evoke debate over why they are different and which regulation strategy is better. Because these pollutants often coexist (mixed waste sites, contaminated metals and facilities, etc.), it is important to analyze inconsistencies in the regulation of chemicals and radionuclides and establish a more consistent approach to defining an acceptable level of exposure for these contaminants.

  19. Crafting regulations in emerging geothermal countries: The Peru example

    SciTech Connect (OSTI)

    Armstrong, A.J.

    1996-12-31

    Conventional wisdom holds that no prudent investor or lender will ante up a penny of investment money in a geothermal project unless and until there is a geothermal resources law in place. Since every law depends on a regulatory regime to make the law work in actual practice, implemented regulations are equally important conditions precedent for geothermal development. In recognition of the importance of assisting geothermal regulatory development in the emerging geothermal countries of Latin America, during the 1995 to 1996 timeframe, the Geothermal Energy Association has acted in an advisory capacity to the Ministry of Energy and Mines of Peru, in the drafting of geothermal regulations for Peru. These regulations are designed to promote developmental investment in the geothermal resources of Peru, while simultaneously establishing reasonable standards for the protection of the people and the environment of the country. While these regulations are specific to Peru, they may well serve as a model for other countries of Latin America. Thus, the lessons learned in crafting the Peru regulatory regime may have applicability in other countries in which the geothermal industry is now working or may work in the future.

  20. Cell fate regulation governed by a repurposed bacterial histidine kinase

    SciTech Connect (OSTI)

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy; Stock, Ann M.

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.

  1. NUCLEAR REGULATOR%'-C~fiMls6N REGION I

    Office of Legacy Management (LM)

    jNrTED ST&ye I ) r P, NUCLEAR REGULATOR%'-CfiMls6N REGION I 63I PIIRK AVENUE Wcs:in;kcse Elecric Coroorrzion ATTiN: 2. F:. jhaw I-- Zivision Piant Manaaer wm.1.1 I SJeszi ...

  2. OSHA safety regulation calls for step-by-step approach

    SciTech Connect (OSTI)

    Bellomo, P.J. (Arthur D. Little Inc., Houston, TX (US))

    1992-06-01

    The U.S. Occupational Safety and Health Administration's long-awaited process safety management (PSM) regulation mandates the implementation of a PSM program at facilities handling highly hazardous materials, including oil refineries and petrochemical plants. This article presents a step-by-step PSM program compliance strategy, delineated and explored through practical examples.

  3. State Regulators Promote Consumer Choice in Retail Gas Markets

    Reports and Publications (EIA)

    1996-01-01

    Restructuring of interstate pipeline companies has created new choices and challenges for local distribution companies (LDCs), their regulators, and their customers. The process of separating interstate pipeline gas sales from transportation service has been completed and has resulted in greater gas procurement options for LDCs.

  4. Cell fate regulation governed by a repurposed bacterial histidine kinase

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy; Stock, Ann M.

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interactionmore » between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.« less

  5. Mandatory petroleum price and allocation regulations: a history and analysis

    SciTech Connect (OSTI)

    Lane, W.C. Jr.

    1981-05-05

    This study is a history and analysis of Federal controls over petroleum price and allocation decisions throughout the 1970's. It relies in large part on the many analyses and comments written by academics, government officials and others who have studied the topic over the past nine years. The first part of this study outlines the conditions in the domestic petroleum market that led to the imposition of first price, and then allocation controls on the oil industry. The second part explores the operation and effectiveness of the regulations during periods of oil supply disruptions - the Arab embargo of 1973-1974 and the 1979 shortfall attendant to the revolution in Iran. The third part describes many of the more important changes made to the regulations during non-disrupted periods, and examines the effect the regulations had on the operation and structure of the domestic oil industry. The last part analyzes the overall effects of the regulations on consumer prices and national welfare.

  6. Marine Hydrokinetic Energy Regulators Workshop: Lessons from Wind

    SciTech Connect (OSTI)

    Baring-Gould, E. Ian

    2015-09-03

    Ian Baring-Gould presented these lessons learned from wind energy to an audience of marine hydrokinetic regulators. Lessons learned spanned the areas of technology advances, using collaborative approaches to involve key stakeholders; using baseline studies to measure and prioritize wildlife impacts, and look at avoidance and mitigation options early in the process.

  7. Effects of new environmental regulations on coal-fired generation

    SciTech Connect (OSTI)

    LaCount, R.

    1999-07-01

    As restructuring of the electricity industry places downward pressure on power production costs, new environmental regulations are having the opposite effect. Although power plants may be subject to a variety of environmental regulations over the next ten years including reductions in mercury, toxics, and carbon dioxide, new regulations for sulfur dioxide (SO2) and nitrogen oxides (NOX) are poised to impact the electricity industry in the very short term. The cost for coal-fired power plants to comply with these new regulations has the potential to alter their competitive position. January 1, 2000 marks the beginning of Phase II for the Environmental Protection Agency's SO2 allowance market. Starting in January, all coal and oil plants above 25 MW will be required to comply with the federal SO2 provisions. Regulatory deadlines for NOX are also fast approaching; though the ultimate requirements are still subject to change. On May 1, 1999, a NOX allowance market began for states within the Northeast Ozone Transport Commission (OTC). A second phase of this program is scheduled to begin in 2003 that will lower the overall cap for allowable NOX emissions in the participating states. EPA is also working to expand the reach of regional NOX reductions in 2003 through its NOX SIP call. This program, which is currently subject to litigation, would require NOX reductions in 14 states outside of the OTC. A new study by Resource Data International (RDI), Coal-Fired Generation in Competitive Power Markets, assessed the potential impact that the new SO2 and NOX regulations may have on the competitiveness of coal-fired generation. Overall, the study shows that coal-fired generation will continue to grow despite significant environmental costs and competition from natural gas-fired units. The new environmental regulations have the effect of increasing the dispatch cost of coal-fired units from $0.65/MWh on average in the WSCC to $4.14/MWh on average in the MAAC region. The addition of environmental adders for SO2 and NOX pushes some coal-fired units above the fuel cost of combined cycle gas-fired units, especially those coal-fired units with poor heat rates and/or high delivered fuel costs. This presentation will review the current regulatory status of both the new SO2 and NOX regulations and address the key findings from RDI's new study.

  8. Photoreactive synthetic regulator of protein function and methods of use thereof

    DOE Patents [OSTI]

    Trauner, Dirk; Isacoff, Ehud Y; Kramer, Richard H; Banghart, Matthew R; Fortin, Doris L; Mourot, Alexandre

    2015-03-31

    The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

  9. 49 CFR Subchapter C, Parts 171-177: Hazardous Materials Regulations

    Broader source: Energy.gov [DOE]

    The U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration regulates the transport of hazardous materials through Title 49 of the Code of Federal Regulations (49 CFR), Subchapter C, "Hazardous Materials Regulations." Parts 171-177 provide general information on hazardous materials and regulation for their packaging and their shipment by rail, air, vessel, and public highway.

  10. Projections of air toxic emissions from coal-fired utility combustion: Input for hazardous air pollutant regulators

    SciTech Connect (OSTI)

    Szpunar, C.B.

    1993-08-01

    The US Environmental Protection Agency (EPA) is required by the 1990 CAAA to promulgate rules for all ``major`` sources of any of these HAPs. According to the HAPs section of the new Title III, any stationary source emitting 10 tons per year (TPY) of one HAP or 25 TPY of a combination of HAPs will be considered and designated a major source. In contrast to the original National Emission Standards for Hazardous Air Pollutants (NESHAP), which were designed to protect public health to ``an ample margin of safety,`` the new Title III, in its first phase, will regulate by industrial category those sources emitting HAPs in excess of the 10/25-TPY threshold levels, regardless of health risks. The trace elements normally associated with coal mineral matter and the various compounds formed during coal combustion have the potential to produce hazardous air toxic emissions from coal-fired electric utilities. Under Title III, the EPA is required to perform certain studies, prior to any regulation of electric utilities; these studies are currently underway. Also, the US Department of Energy (DOE) maintains a vested interest in addressing those energy policy questions affecting electric utility generation, coal mining, and steel producing critical to this country`s economic well-being, where balancing the costs to the producers and users of energy with the benefits of environmental protection to the workers and the general populace remains of significant concern.

  11. RNA Helicase DDX5 Regulates MicroRNA Expression and Contributes to Cytoskeletal Reorganization in Basal Breast Cancer Cells

    SciTech Connect (OSTI)

    Wang, Daojing; Huang, Jing; Hu, Zhi

    2011-11-15

    RNA helicase DDX5 (also p68) is involved in all aspects of RNA metabolism and serves as a transcriptional co-regulator, but its functional role in breast cancer remains elusive. Here, we report an integrative biology study of DDX5 in breast cancer, encompassing quantitative proteomics, global MicroRNA profiling, and detailed biochemical characterization of cell lines and human tissues. We showed that protein expression of DDX5 increased progressively from the luminal to basal breast cancer cell lines, and correlated positively with that of CD44 in the basal subtypes. Through immunohistochemistry analyses of tissue microarrays containing over 200 invasive human ductal carcinomas, we observed that DDX5 was upregulated in the majority of malignant tissues, and its expression correlated strongly with those of Ki67 and EGFR in the triple-negative tumors. We demonstrated that DDX5 regulated a subset of MicroRNAs including miR-21 and miR-182 in basal breast cancer cells. Knockdown of DDX5 resulted in reorganization of actin cytoskeleton and reduction of cellular proliferation. The effects were accompanied by upregulation of tumor suppressor PDCD4 (a known miR-21 target); as well as upregulation of cofilin and profilin, two key proteins involved in actin polymerization and cytoskeleton maintenance, as a consequence of miR-182 downregulation. Treatment with miR-182 inhibitors resulted in morphologic phenotypes resembling those induced by DDX5 knockdown. Using bioinformatics tools for pathway and network analyses, we confirmed that the network for regulation of actin cytoskeleton was predominantly enriched for the predicted downstream targets of miR-182. Our results reveal a new functional role of DDX5 in breast cancer via the DDX5?miR-182?actin cytoskeleton pathway, and suggest the potential clinical utility of DDX5 and its downstream MicroRNAs in the theranostics of breast cancer.

  12. Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS

    SciTech Connect (OSTI)

    Yoon, Sung-Jin; Park, Jun-Young; Choi, Song; Lee, Jin-Bong; Jung, Haiyoung; Kim, Tae-Don; Yoon, Suk Ran; Choi, Inpyo; Shim, Sungbo; Park, Young-Jun

    2015-08-07

    Ginsenoside Rg3, a specific biological effector, is well-known as a major bioactive ingredient of Panax ginseng. However, its role in the inflammasome activation process remains unclear. In this report, we demonstrate that ginsenosides 20(R)-Rg3 and 20(S)-Rg3 are capable of suppressing both lethal endotoxic shock and the S-nitrosylation of the NLRP3 inflammasome by inhibiting nitric oxide (NO) production through the regulation of inducible nitric oxide synthase (iNOS) expression. In response to lipopolysaccharide (LPS), the reducing effect of 20(S)-Rg3 and 20(R)-Rg3 on nitric oxide led to an increase in the survival time of mice after lethal endotoxin-induced shock, and excess levels of NO inhibited IL-1β production via the S-nitrosylation of the NLRP3 inflammasome. In addition, ginsenosides 20(R)-Rg3 and 20(S)-Rg3 had suppressive effects on the LPS- or UV-irradiation-induced reactive oxygen species (ROS) levels in macrophage and HaCaT cells and thereby prevented apoptosis of spleen cells in mice. Altogether, these results demonstrate that ginsenoside 20(R)-Rg3 and 20(S)-Rg3, a naturally occurring compound, might act as a dual therapeutic regulator for the treatment of inflammatory and oxidative stress-related diseases. - Highlights: • Ginsenosides Rg3 inhibits NO production through the regulation of iNOS expression. • Ginsenosides Rg3 inhibits the S-nitrosylation of the NLRP3 inflammasome. • Ginsenosides Rg3 suppress on the LPS- or UV-irradiation-induced ROS levels in cells.

  13. Legal nature of LPG (liquefied petroleum gas) regulation

    SciTech Connect (OSTI)

    Liddell, G.

    1986-08-01

    The commercial exploitation of Liquefied Petroleum Gas (LPG) in New Zealand has occurred without a particular and comprehensive concern for any legal implications. The paper in Part I examines definitional questions, assesses in Part II the ability of courts and quasi-courts to evaluate risks associated with the product, examines in Part III the utility of common law remedies for injuries or associated with or arising from LPG, analyzes in Part IV the statutory regulation of LPG, concentrating particularly on the Dangerous Goods (Class 2 - Gases) Regulations 1980, discusses in Part V recent planning case-law concerning LPG development, and concludes that some reform is necessary to produce a more-coherent and precise regulatory regime that takes into account both the needs of developers and those affected by the development of LPG.

  14. Regulators caught in fierce crossfire on new generation

    SciTech Connect (OSTI)

    2008-07-15

    Efforts of several utilities to construct new power plants not based on conventional coal but rather coal-gasification technology or nuclear fission are described. Several have been canceled because of rising costs. State regulators are faced with trying to protect customers from high rates and unsound investments by utilities. Critics maintain that ratepayers should not be forced to pay higher rates for plants that may never be built.

  15. Enforcement Regulations and Directives - Security | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Security Enforcement Regulations and Directives - Security Classified Information Security 10 C.F.R Part 824 - Procedural Rules for the Assessment of Civil Penalties for Classified Information Security Violations 10 C.F.R Part 1016 - Safeguarding of Restricted Data 10 C.F.R Part 1045 - Nuclear Classification and Declassification DOE Directives and NNSA Policy Letters Enforceable under 10 C.F.R. Part 824

  16. New insights into regulating the gut's microbial community | Argonne

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    National Laboratory insights into regulating the gut's microbial community August 27, 2015 Tweet EmailPrint The human body is home to billions of microbial cells, a number roughly three to 10 times greater than the number of human cells. Many of these microbes reside in the gastrointestinal system, or gut, and form a symbiotic relationship with their human hosts. These "commensal" organisms do not causes illness and in fact provide us with crucial metabolic and nutritional benefits

  17. NREL: Technology Deployment - Fleets Regulated by the Energy Policy Act

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fleets Regulated by the Energy Policy Act NREL supports the U.S. Department of Energy's (DOE) regulatory activities involving requirements under the Energy Policy Act (EPAct) for federal, state, and alternative fuel provider fleets. Congress passed EPAct in 1992 to reduce U.S. petroleum consumption through the use of alternative fuels, alternative fuel vehicles (AFVs), and other petroleum-displacement methods. DOE's primary means of achieving this goal in the transportation sector has been to

  18. DOE's Program Regulating Liquefied Natural Gas Export Applications |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 19, 2013 - 2:52pm Addthis Statement of Christopher Smith, Acting Assistant Secretary for Fossil Energy before the House Committee on Oversight and Government Reform, Subcommittee on Energy Policy, Health Care, and Entitlements View the archived Congressional Hearing on YouTube Thank you Chairman Lankford, Ranking Member Speier, and members of the Committee; I appreciate the opportunity to be here today to discuss the Department of Energy's (DOE) program regulating the

  19. DOE's Program Regulating Liquefied Natural Gas Export Applications |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 25, 2014 - 2:49pm Addthis Statement of Paula Gant, Deputy Assistant Secretary for Oil and Natural Gas, Before the House Subcommittee on Energy and Power, Committee on Energy and Commerce Thank you Chairman Whitfield, Ranking Member Rush, and members of the Subcommittee; I appreciate the opportunity to be here today to discuss the Department of Energy's (DOE) program regulating the export of liquefied natural gas (LNG), and to answer questions about H.R. 6, the

  20. Application of EPA regulations to low-level radioactive waste

    SciTech Connect (OSTI)

    Bowerman, B.S.; Piciulo, P.L.

    1985-01-01

    The survey reported here was conducted with the intent of identifying categories of low-level radioactive wastes which would be classified under EPA regulations 40 CFR Part 261 as hazardous due to the chemical properties of the waste. Three waste types are identified under these criteria as potential radioactive mixed wastes: wastes containing organic liquids; wastes containing lead metal; and wastes containing chromium. The survey also indicated that certain wastes, specific to particular generators, may also be radioactive mixed wastes. Ultimately, the responsibility for determining whether a facility's wastes are mixed wastes rest with the generator. However, the uncertainties as to which regulations are applicable, and the fact that no legal definition of mixed wastes exists, make such a determination difficult. In addition to identifying mixed wastes, appropriate methods for the management of mixed wastes must be defined. In an ongoing study, BNL is evaluating options for the management of mixed wastes. These options will include segregation, substitution, and treatments to reduce or eliminate chemical hazards associated with the wastes listed above. The impacts of the EPA regulations governing hazardous wastes on radioactive mixed waste cannot be assessed in detail until the applicability of these regulations is agreed upon. This issue is still being discussed by EPA and NRC and should be resolved in the near future. Areas of waste management which may affect generators of mixed wastes include: monitoring/tracking of wastes before shipment; chemical testing of wastes; permits for treatment of storage of wastes; and additional packaging requirements. 3 refs., 1 fig., 2 tabs.

  1. Regulation Services with Demand Response - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulation Services with Demand Response Pacific Northwest National Laboratory Contact PNNL About This Technology Using grid frequency information, researchers have created algorithms that intelligently control power demand while meeting consumer objectives (i.e. target pricing). Using grid frequency information, researchers have created algorithms that intelligently control power demand while meeting consumer objectives (i.e. target pricing). Technology Marketing Summary Grid Friendly(tm)

  2. Code of Federal Regulations Occupational Radiation Protection; Final Rule |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Occupational Radiation Protection; Final Rule Code of Federal Regulations Occupational Radiation Protection; Final Rule The Department of Energy (DOE) is amending its primary standards for occupational radiation protection. This final rule is the culmination of a systematic analysis to identify the elements of a comprehensive radiation protection program and determine those elements of such a program that should be codified as DOE continues its transition from a system

  3. Environmental regulation of coal mining. SMCRA`s Second Decade

    SciTech Connect (OSTI)

    McElfish, J.M.; Beier, A.E.

    1990-12-31

    If you find yourself involved in the workings of the Surface Mining Control and Reclamation Act of 1977 (SMCRA), let ELI`s guide take you through SMCRA`s second decade. Environmental Regulation of Coal mining: SMCRA`s Second Decade gives you a clear picture of SMCRA`s statutory and regulatory requirements, and identifies the key policy disputes and problems that will be confronted in the years ahead.

  4. Physiology and Regulation of Calcium Channels in Stomatal Guard Cells

    SciTech Connect (OSTI)

    Schroeder, Julian I.

    2007-05-02

    Stomatal pores in the epidermis of leaves regulate the diffusion of CO2 into leaves for photosynthetic carbon fixation and control water loss of plants during drought periods. Guard cells sense CO2, water status, light and other environmental conditions to regulate stomatal apertures for optimization of CO2 intake and plant growth under drought stress. The cytosolic second messenger calcium contributes to stomatal movements by transducing signals and regulating ion channels in guard cells. Studies suggest that both plasma membrane Ca2+ influx channels and vacuolar/organellar Ca2+ release channels contribute to ABA-induced Ca2+ elevations in guard cells. Recent research in the P.I.'s laboratory has led to identification of a novel major cation-selective Ca2+-permeable influx channel (Ica) in the plasma membrane of Arabidopsis guard cells. These advances will allow detailed characterization of Ica plasma membrane Ca2+ influx channels in guard cells. The long term goal of this research project is to gain a first detailed characterization of these novel plasma membrane Ca2+-permeable channel currents in Arabidopsis guard cells. The proposed research will investigate the hypothesis that Ica represents an important Ca2+ influx pathway for ABA and CO2 signal transduction in Arabidopsis guard cells. These studies will lead to elucidation of key signal transduction mechanisms by which plants balance CO2 influx into leaves and transpirational water loss and may contribute to future strategies for manipulating gas exchange for improved growth of crop plants and for biomass production.

  5. Comparative genomics of transcriptional regulation of methionine metabolism in proteobacteria

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Leyn, Semen A.; Suvorova, Inna A.; Kholina, Tatiana D.; Sherstneva, Sofia S.; Novichkov, Pavel S.; Gelfand, Mikhail S.; Rodionov, Dmitry A.; Kuipers, Oscar P.

    2014-11-20

    Methionine metabolism and uptake genes in Proteobacteria are controlled by a variety of RNA and DNA regulatory systems. We have applied comparative genomics to reconstruct regulons for three known transcription factors, MetJ, MetR, and SahR, and three known riboswitch motifs, SAH, SAM-SAH, and SAM_alpha, in ~200 genomes from 22 taxonomic groups of Proteobacteria. We also identified two novel regulons: a SahR-like transcription factor SamR controlling various methionine biosynthesis genes in the Xanthomonadales group, and a potential RNA regulatory element with terminator-antiterminator mechanism controlling the metX or metZ genes in beta-proteobacteria. For each analyzed regulator we identified the core, taxon-specific andmore » genome-specific regulon members. By analyzing the distribution of these regulators in bacterial genomes and by comparing their regulon contents we elucidated possible evolutionary scenarios for the regulation of the methionine metabolism genes in Proteobacteria.« less

  6. DC switching regulated power supply for driving an inductive load

    DOE Patents [OSTI]

    Dyer, G.R.

    1983-11-29

    A dc switching regulated power supply for driving an inductive load is provided. The regulator basic circuit is a bridge arrangement of diodes and transistors. First and second opposite legs of the bridge are formed by first and second parallel-connected transistor arrays, respectively, while the third and fourth legs of the bridge are formed by appropriately connected first and second parallel connected diode arrays, respectively. A dc power supply is connected to the input of the bridge and the output is connected to the load. A servo controller is provided to control the switching rate of the transistors to maintain a desired current to the load. The regulator may be operated in three stages or modes: (1) for current runup in the load, both first and second transistor switch arrays are turned on and current is supplied to the load through both transistor arrays. (2) When load current reaches the desired level, the first switch is turned off, and load current flywheels through the second switch array and the fourth leg diode array connecting the second switch array in series with the load. Current is maintained by alternating between modes 1 and 2 at a suitable duty cycle and switching rate set by the controller. (3) Rapid current rundown is accomplished by turning both switch arrays off, allowing load current to be dumped back into the source through the third and fourth diode arrays connecting the source in series opposition with the load to recover energy from the inductive load.

  7. DC switching regulated power supply for driving an inductive load

    DOE Patents [OSTI]

    Dyer, George R.

    1986-01-01

    A power supply for driving an inductive load current from a dc power supply hrough a regulator circuit including a bridge arrangement of diodes and switching transistors controlled by a servo controller which regulates switching in response to the load current to maintain a selected load current. First and second opposite legs of the bridge are formed by first and second parallel-connected transistor arrays, respectively, while the third and fourth legs of the bridge are formed by appropriately connected first and second parallel connected diode arrays, respectively. The regulator may be operated in three "stages" or modes: (1) For current runup in the load, both first and second transistor switch arrays are turned "on" and current is supplied to the load through both transistor arrays. (2) When load current reaches the desired level, the first switch is turned "off", and load current "flywheels" through the second switch array and the fourth leg diode array connecting the second switch array in series with the load. Current is maintained by alternating between modes 1 and 2 at a suitable duty cycle and switching rate set by the controller. (3) Rapid current rundown is accomplished by turning both switch arrays "off", allowing load current to be dumped back into the source through the third and fourth diode arrays connecting the source in series opposition with the load to recover energy from the inductive load. The three operating states are controlled automatically by the controller.

  8. Comparative genomics of transcriptional regulation of methionine metabolism in proteobacteria

    SciTech Connect (OSTI)

    Leyn, Semen A.; Suvorova, Inna A.; Kholina, Tatiana D.; Sherstneva, Sofia S.; Novichkov, Pavel S.; Gelfand, Mikhail S.; Rodionov, Dmitry A.; Kuipers, Oscar P.

    2014-11-20

    Methionine metabolism and uptake genes in Proteobacteria are controlled by a variety of RNA and DNA regulatory systems. We have applied comparative genomics to reconstruct regulons for three known transcription factors, MetJ, MetR, and SahR, and three known riboswitch motifs, SAH, SAM-SAH, and SAM_alpha, in ~200 genomes from 22 taxonomic groups of Proteobacteria. We also identified two novel regulons: a SahR-like transcription factor SamR controlling various methionine biosynthesis genes in the Xanthomonadales group, and a potential RNA regulatory element with terminator-antiterminator mechanism controlling the metX or metZ genes in beta-proteobacteria. For each analyzed regulator we identified the core, taxon-specific and genome-specific regulon members. By analyzing the distribution of these regulators in bacterial genomes and by comparing their regulon contents we elucidated possible evolutionary scenarios for the regulation of the methionine metabolism genes in Proteobacteria.

  9. Final Report for Regulation of Embryonic Development in Higher Plants

    SciTech Connect (OSTI)

    Harada, John J.

    2013-10-22

    The overall goal of the project was to define the cellular processes that underlie embryo development in plants at a mechanistic level. Our studies focused on a critical transcriptional regulator, Arabidopsis LEAFY COTYLEDON (LEC1), that is necessary and sufficient to induce processes required for embryo development. Because LEC1 regulates lipid accumulation during the maturation phase of embryo development, information about LEC1 may be useful in designing approaches to enhance biofuel production in plants. During the tenure of this project, we determined the molecular mechanisms by which LEC1 acts as a transcription factor in embryos. We also identified genes directly regulated by LEC1 and showed that many of these genes are involved in maturation processes. This information has been useful in dissecting the gene regulatory networks controlling embryo development. Finally, LEC1 is a novel isoform of a transcription factor that is conserved among eukaryotes, and LEC1 is active primarily in seeds. Therefore, we determined that the LEC1-type transcription factors first appeared in lycophytes during land plant evolution. Together, this study provides basic information that has implications for biofuel production.

  10. Structure-based functional characterization of repressor of toxin (Rot), a central regulator of staphylococcus aureus virulence

    SciTech Connect (OSTI)

    Killikelly, April; Jakoncic, Jean; Benson, Meredith A.; Ohneck, Elizabeth A.; Sampson, Jared M.; Spurrier, Brett; Torres, Victoer J.; Kong, Xian -Peng

    2014-10-20

    Staphylococcus aureus is responsible for a large number of diverse infections worldwide. In order to support its pathogenic lifestyle, S. aureus has to regulate the expression of virulence factors in a coordinated fashion. One of the central regulators of the S. aureus virulence regulatory networks is the transcription factor repressor of toxin (Rot). Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors. However, the mechanism by which Rot mediates gene regulation has remained elusive. Here, we have determined the crystal structure of Rot and used this information to probe the contribution made by specific residues to Rot function. Rot was found to form a dimer, with each monomer harboring a winged helix-turn-helix (WHTH) DNA-binding motif. Despite an overall acidic pI, the asymmetric electrostatic charge profile suggests that Rot can orient the WHTH domain to bind DNA. Structure-based site-directed mutagenesis studies demonstrated that R91, at the tip of the wing, plays an important role in DNA binding, likely through interaction with the minor groove. We also found that Y66, predicted to bind within the major groove, contributes to Rot interaction with target promoters. Evaluation of Rot binding to different activated and repressed promoters revealed that certain mutations on Rot exhibit promoter-specific effects, suggesting for the first time that Rot differentially interacts with target promoters. As a result, this work provides insight into a precise mechanism by which Rot controls virulence factor regulation in S. aureus.

  11. Price Incentivised Electric Vehicle Charge Control for Community Voltage Regulation

    SciTech Connect (OSTI)

    Kelly, Damian; Baroncelli, Fabio; Fowler, Christopher; Boundy, David; Pratt, Annabelle

    2014-11-03

    With the growing availability of Electric Vehicles, there is a significant opportunity to use battery 'smart-charging' for voltage regulation. This work designs and experimentally evaluates a system for price-incentivised electric vehicle charging. The system is designed to eliminate negative impacts to the user while minimising the cost of charging and achieving a more favourable voltage behaviour throughout the local grid over time. The practical issues associated with a real-life deployment are identified and resolved. The efficacy of the system is evaluated in the challenging scenario in which EVs are deployed in six closely distributed homes, serviced by the same low voltage residential distribution feeder.

  12. Enforcement Regulations and Directives - Nuclear Safety | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Nuclear Safety Enforcement Regulations and Directives - Nuclear Safety 10 C.F.R. Part 820 and Amendments 10 C.F.R. Part 820 - Procedural Rules for DOE Nuclear Activities 10 C.F.R. Part 820 - Procedural Rules for DOE Nuclear Activities; General Statement of Enforcement Policy; Final rule; amendment of enforcement policy statement and confirmation of interim rule Enforcement Guidance Supplements 10 C.F.R. Part 830 10 C.F.R. Part 830 - Nuclear Safety Management; Final Rule Office of

  13. Department of Energy Federal Acquisition Regulation Clause Usage Guide

    Broader source: Energy.gov [DOE]

    Attached for your information is a corrected Department of Energy Federal Acquisition Regulation Clause Usage Guide. This corrected clause matrix is also being posted to the Stripes library. The earlier edition incorrectly designated 52.223-4 Recovered Material Certification and 52.223-9 Estimate of Percentage of Recovered Material Content for EPA-Designated Items, as Not Applicable under management and operating contracts and other facility management contracts. They are actually required clauses as 52.223-17 requires the use of such products in service and construction contracts. They are also being designated as required under the service and construction contract columns.

  14. Structure, Function and Regulation of the Clostridium cellulovorans Cellulosome

    SciTech Connect (OSTI)

    Doi, Roy H

    2008-06-01

    Our major goal for this project (2004-2008) was to obtain an understanding ofthe structure, function, and regulation of the Clostridium cellulovorans cellulosomes. Our specific goals were to select genes for cellulosomal and non-cellulosomal enzymes and characterize their products, to study the synergistic action between cellulosomal and non-cellulosomal enzymes, to study the composition of cellulosomes when cells were grown with different carbon sources, continue our studies on the scaffolding protein and examine heterologous expression of cellulosomal genes in Bacillus subtilis. We fulfilled the specific goals of our proposal.

  15. REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST...

    Office of Scientific and Technical Information (OSTI)

    REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW ... Title: REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW ...

  16. 2 CCR 402-10 - Rules and Regulations for Geothermal Well Permitting...

    Open Energy Info (EERE)

    2 CCR 402-10 - Rules and Regulations for Geothermal Well PermittingLegal Abstract Sets forth regulation for issuance of geothermal well permits by the Division of Water Resources....

  17. Division of Natural Gas Regulation (Import/Export) - E-Filing...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Division of Natural Gas Regulation (ImportExport) - E-Filing Division of Natural Gas Regulation (ImportExport) - E-Filing E-File Your Application Welcome to the Division of ...

  18. State Air Emission Regulations That Affect Electric Power Producers (Update) (released in AEO2006)

    Reports and Publications (EIA)

    2006-01-01

    Several states have recently enacted air emission regulations that will affect the electricity generation sector. The regulations govern emissions of NOx, SO2, CO2, and mercury from power plants.

  19. "A Regulator's Privacy Guide to Third-Party Data Access for Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    "A Regulator's Privacy Guide to Third-Party Data Access for Energy Efficiency" Now Available "A Regulator's Privacy Guide to Third-Party Data Access for Energy Efficiency" Now...

  20. DOE-SPEC-3019-96; Valve-Regulated Type Lead-Acid Storage Batteries

    Office of Environmental Management (EM)

    DOE SPECIFICATION VALVE-REGULATED TYPE LEAD-ACID STORAGE BATTERIES U.S. Department of ... valve-regulated type lead-acid storage batteries, organized as follows: &21; Parts 1 through ...

  1. NMR Characterization of C3H and HCT Down-Regulated Alfalfa Lignin...

    Office of Scientific and Technical Information (OSTI)

    NMR Characterization of C3H and HCT Down-Regulated Alfalfa Lignin Citation Details In-Document Search Title: NMR Characterization of C3H and HCT Down-Regulated Alfalfa Lignin ...

  2. 2012 CERTS LAAR Program Peer Review - Scoping Study on Industrial Regulation - Nasr Alkadi, ORNL

    Energy Savers [EERE]

    Nasr Alkadi, Ph.D. Michael Starke, PhD Oak Ridge National Laboratory CERTS Internal Program Review FY12 DOE-CERTS Transmission Reliability R&D at Lawrence Berkeley National Laboratory. Scoping Study on Industrial Regulation September 20, 2012 2 Managed by UT-Battelle for the U.S. Department of Energy Project objective: Scoping of Regulation Reserves in Industrial Sector 2 Alcoa's Smelting Process is a significant regulation asset at Warrick, IN. * Alcoa has demonstrated Regulation Band in

  3. DOE Seeks Public Views On How Best To Streamline Existing Regulations |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Public Views On How Best To Streamline Existing Regulations DOE Seeks Public Views On How Best To Streamline Existing Regulations January 31, 2011 - 5:53pm Addthis The Department of Energy today announced two immediate steps to implement the Obama Administration's Executive Order on Improving Regulation and Regulatory Review, which directs federal agencies to review existing regulations and determine whether they are still necessary and crafted effectively to solve

  4. "Cybersecurity for State Regulators" - NARUC Primer (June 2012) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy "Cybersecurity for State Regulators" - NARUC Primer (June 2012) "Cybersecurity for State Regulators" - NARUC Primer (June 2012) The National Association of Regulatory Utility Commissioners (NARUC) released "Cybersecurity for State Regulators," a primer that explains conceptual cybersecurity basics and points to additional resources that can help regulators develop internal cybersecurity expertise, ask questions of their utilities, engage in

  5. 40 CFR 1500-1508: CEQ Regulations for Implementing the Procedural

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Provisions of NEPA | Department of Energy 40 CFR 1500-1508: CEQ Regulations for Implementing the Procedural Provisions of NEPA 40 CFR 1500-1508: CEQ Regulations for Implementing the Procedural Provisions of NEPA PDF icon CEQ Regulations for Implementing the Procedural Provisions of NEPA (40 CFR 1500-1508) More Documents & Publications Effective Public Participation (DOE, 1998) Forty Most Asked Questions Concerning CEQ's National Environmental Policy Act Regulations (CEQ, 1986) A

  6. Guide to Federal Regulation of Sales of Imported Electricity in Canada,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Mexico and the United States | Department of Energy Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States A Publication of The North American Energy Working Group on January 2005 PDF icon Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States More Documents & Publications North America: Regulation of

  7. Regulations and Requirements | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulations and Requirements Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review Boards (IRBs) Education and Resources Regulations and Requirements Ethical Principles Federal Regulations DOE Special Requirements Health Insurance Portability and Accountability Act (HIPAA) Glossary Abbreviations Contact BER Home Contact Information Human Subjects Protection Program U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585

  8. MEIS1 functions as a potential AR negative regulator

    SciTech Connect (OSTI)

    Cui, Liang; Yang, Yutao; Hang, Xingyi; Cui, Jiajun; Gao, Jiangping

    2014-10-15

    The androgen receptor (AR) plays critical roles in human prostate carcinoma progression and transformation. However, the activation of AR is regulated by co-regulators. MEIS1 protein, the homeodomain transcription factor, exhibited a decreased level in poor-prognosis prostate tumors. In this study, we investigated a potential interaction between MEIS1 and AR. We found that overexpression of MEIS1 inhibited the AR transcriptional activity and reduced the expression of AR target gene. A potential proteinprotein interaction between AR and MEIS1 was identified by the immunoprecipitation and GST pull-down assays. Furthermore, MEIS1 modulated AR cytoplasm/nucleus translocation and the recruitment to androgen response element in prostate specific antigen (PSA) gene promoter sequences. In addition, MEIS1 promoted the recruitment of NCoR and SMRT in the presence of R1881. Finally, MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells. Taken together, our data suggests that MEIS1 functions as a novel AR co-repressor. - Highlights: A potential interaction was identified between MEIS1 and AR signaling. Overexpression of MEIS1 reduced the expression of AR target gene. MEIS1 modulated AR cytoplasm/nucleus translocation. MEIS1 inhibited the proliferation and anchor-independent growth of LNCaP cells.

  9. New Tax Regulations Help Further Low Income Solar | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Tax Regulations Help Further Low Income Solar New Tax Regulations Help Further Low Income Solar April 1, 2016 - 2:50pm Addthis Newly published regulations from the IRS will help more low-income residents benefit from solar installations. The IRS issued temporary rules to clarify the Low-Income Housing Tax Credit's (LIHTC) utility allowance regulations, which allow people who fall into the low-income category to receive a tax credit. The final regulations state that utility costs paid by a tenant

  10. Structural basis of AMPK regulation by adenine nucleotides and glycogen

    SciTech Connect (OSTI)

    Li, Xiaodan; Wang, Lili; Zhou, X. Edward; Ke, Jiyuan; de Waal, Parker W.; Gu, Xin; Tan, M. H. Eileen; Wang, Dongye; Wu, Donghai; Xu, H. Eric; Melcher, Karsten

    2014-11-21

    AMP-activated protein kinase (AMPK) is a central cellular energy sensor and regulator of energy homeostasis, and a promising drug target for the treatment of diabetes, obesity, and cancer. Here we present low-resolution crystal structures of the human α1β2γ1 holo-AMPK complex bound to its allosteric modulators AMP and the glycogen-mimic cyclodextrin, both in the phosphorylated (4.05 Å) and non-phosphorylated (4.60 Å) state. In addition, we have solved a 2.95 Å structure of the human kinase domain (KD) bound to the adjacent autoinhibitory domain (AID) and have performed extensive biochemical and mutational studies. Altogether, these studies illustrate an underlying mechanism of allosteric AMPK modulation by AMP and glycogen, whose binding changes the equilibria between alternate AID (AMP) and carbohydrate-binding module (glycogen) interactions.

  11. Regulation and Function of Adult Neurogenesis. From Genes to Cognition

    SciTech Connect (OSTI)

    Aimone, J. B.; Li, Y.; Lee, S. W.; Clemenson, G. D.; Deng, W.; Gage, F. H.

    2014-10-01

    Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. Our review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. Furthermore, the increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.

  12. Regulation and Function of Adult Neurogenesis. From Genes to Cognition

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Aimone, J. B.; Li, Y.; Lee, S. W.; Clemenson, G. D.; Deng, W.; Gage, F. H.

    2014-10-01

    Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. Our review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages ofmore » maturation, ultimately integrating into the adult dentate gyrus network. Furthermore, the increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.« less

  13. GATA-1 directly regulates Nanog in mouse embryonic stem cells

    SciTech Connect (OSTI)

    Li, Wen-Zhong; Ai, Zhi-Ying; Wang, Zhi-Wei; Chen, Lin-Lin; Guo, Ze-Kun; Zhang, Yong

    2015-09-25

    Nanog safeguards pluripotency in mouse embryonic stem cells (mESCs). Insight into the regulation of Nanog is important for a better understanding of the molecular mechanisms that control pluripotency of mESCs. In a silico analysis, we identify four GATA-1 putative binding sites in Nanog proximal promoter. The Nanog promoter activity can be significantly repressed by ectopic expression of GATA-1 evidenced by a promoter reporter assay. Mutation studies reveal that one of the four putative binding sites counts for GATA-1 repressing Nanog promoter activity. Direct binding of GATA-1 on Nanog proximal promoter is confirmed by electrophoretic mobility shift assay and chromatin immunoprecipitation. Our data provide new insights into the expanded regulatory circuitry that coordinates Nanog expression. - Highlights: • The Nanog proximal promoter conceives functional element for GATA-1. • GATA-1 occupies the Nanog proximal promoter in vitro and in vivo. • GATA-1 transcriptionally suppresses Nanog.

  14. Structural basis of AMPK regulation by adenine nucleotides and glycogen

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Xiaodan; Wang, Lili; Zhou, X. Edward; Ke, Jiyuan; de Waal, Parker W.; Gu, Xin; Tan, M. H. Eileen; Wang, Dongye; Wu, Donghai; Xu, H. Eric; et al

    2014-11-21

    AMP-activated protein kinase (AMPK) is a central cellular energy sensor and regulator of energy homeostasis, and a promising drug target for the treatment of diabetes, obesity, and cancer. Here we present low-resolution crystal structures of the human α1β2γ1 holo-AMPK complex bound to its allosteric modulators AMP and the glycogen-mimic cyclodextrin, both in the phosphorylated (4.05 Å) and non-phosphorylated (4.60 Å) state. In addition, we have solved a 2.95 Å structure of the human kinase domain (KD) bound to the adjacent autoinhibitory domain (AID) and have performed extensive biochemical and mutational studies. Altogether, these studies illustrate an underlying mechanism of allostericmore » AMPK modulation by AMP and glycogen, whose binding changes the equilibria between alternate AID (AMP) and carbohydrate-binding module (glycogen) interactions.« less

  15. Federal Air Emissions Regulations (released in AEO2006)

    Reports and Publications (EIA)

    2006-01-01

    In 2005, the Environmental Protection Agency (EPA) finalized two regulations, the Clean Air Interstate Rule (CAIR) and the Clean Air Mercury Rule CAMR, that would reduce emissions from coal-fired power plants in the United States. Both CAIR and CAMR are included in the Annual Energy Outlook 2006 reference case. The EPA has received 11 petitions for reconsideration of CAIR and has provided an opportunity for public comment on reconsidering certain aspects of CAIR. Public comments were accepted until January 13, 2006. The EPA has also received 14 petitions for reconsideration of CAMR and is willing to reconsider certain aspects of the rule. Public comments were accepted for 45 days after publication of the reconsideration notice in the Federal Register. Several states and organizations have filed lawsuits against CAMR. The ultimate decision of the courts will have a significant impact on the implementation of CAMR.

  16. Regulation control and energy management scheme for wireless power transfer

    SciTech Connect (OSTI)

    Miller, John M.

    2015-12-29

    Power transfer rate at a charging facility can be maximized by employing a feedback scheme. The state of charge (SOC) and temperature of the regenerative energy storage system (RESS) pack of a vehicle is monitored to determine the load due to the RESS pack. An optimal frequency that cancels the imaginary component of the input impedance for the output signal from a grid converter is calculated from the load of the RESS pack, and a frequency offset f* is made to the nominal frequency f.sub.0 of the grid converter output based on the resonance frequency of a magnetically coupled circuit. The optimal frequency can maximize the efficiency of the power transfer. Further, an optimal grid converter duty ratio d* can be derived from the charge rate of the RESS pack. The grid converter duty ratio d* regulates wireless power transfer (WPT) power level.

  17. Educational program on potential impacts of regulated underground storage tanks

    SciTech Connect (OSTI)

    Titus, E.W.

    1995-12-01

    This paper defines a brief (three to four hours) and effective method of educating future environmental professionals, concerned citizens of the community, or local government officials about the long term residual contamination potential posed by underground storage tank sites (UST`s). The format will be designed so that the student will have a clear understanding of the function and capabilities of UST systems, the required monitoring and maintenance, and the extensive commitments necessary to remediate a contaminated site. Subject material covered will include regulation overview, system design and installation, current remediation technologies and future trends. The curriculum will be presented in lecture/workshop format, and will feature color photographs, sites studies and relevant maps. Hypothetical statistical and chemical analytical results will be supplied for interpretation. The student will synthesize, in participatory work groups, the information using some of the various types of UST evaluation systems and formats currently in use by the individual states. This approach exposes the student to participatory group planning and decision making. This type of learning experience would be of significant value because UST`s have left an indelible mark on many street corners across the country. A variety of factors, such as population shifts from urban to suburban areas, governmental regulations, and overhead costs, caused many business owners to want to close their existing UST sites and sell the property. With these closed or abandoned sites comes the potential for soil and groundwater contamination due to petroleum product spillage, or leaking UST`s still under the surface of the site. The goal of this comprehensive approach is to enable the student to make informed judgements as to both the current and long term risks of UST systems. As an additional benefit these individuals will gain a better understanding about their local environment.

  18. REGULATION OF THE SPECTRAL PEAK IN GAMMA-RAY BURSTS

    SciTech Connect (OSTI)

    Beloborodov, Andrei M.

    2013-02-20

    Observations indicate that the peak of a gamma-ray burst spectrum forms in the opaque region of an ultrarelativistic jet. Recent radiative transfer calculations support this picture and show that the spectral peak is inherited from initially thermal radiation, which is changed by heating into a broad photon distribution with a high-energy tail. We discuss the processes that regulate the observed position of the spectral peak E {sub pk}. The opaque jet has three radial zones: (1) the Planck zone r < R {sub P} where a blackbody spectrum is enforced; this zone ends where the Thomson optical depth decreases to {tau} Almost-Equal-To 10{sup 5}, (2) the Wien zone R {sub P} < r < R {sub W} with a Kompaneets parameter y >> 1 where radiation has a Bose-Einstein spectrum, and (3) the Comptonization zone r > R {sub W} where the radiation spectrum develops a high-energy tail. Besides the initial jet temperature, an important factor regulating E {sub pk} is internal dissipation (of bulk motions and magnetic energy) at large distances from the central engine. Dissipation in the Planck zone reduces E {sub pk}, and dissipation in the Wien zone can increase E {sub pk}. In jets with subdominant magnetic fields, the predicted E {sub pk} varies around 1 MeV up to a maximum value of about 10 MeV. If the jet carries an energetically important magnetic field, E {sub pk} can be additionally increased by dissipation of magnetic energy. This increase is suggested by observations, which show E {sub pk} up to about 20 MeV. We also consider magnetically dominated jets; then a simple model of magnetic dissipation gives E {sub pk} Almost-Equal-To 30 {Gamma}{sub W} keV where {Gamma}{sub W} is the jet Lorentz factor at the Wien radius R {sub W}.

  19. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect (OSTI)

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  20. A linear MOSFET regulator for improving performance of the booster ramping power supplies at the APS.

    SciTech Connect (OSTI)

    Feng, G.; Deriy, B.; Wang, J.; Accelerator Systems Division

    2008-01-01

    The APS booster ring uses ramping power supplies to power the sextupole, quadrupole, and dipole magnets as the beam energy ramps up linearly to 7 GeV. Due to the circuit topology used, those supplies are unable to follow the linear ramp to the desired accuracy. The best regulation achieved is 0.25% while 0.1% is desired. In addition to the unsatisfying regulation, those supplies are sensitive to AC line perturbation and are not able to reject AC line noises of more than a few tens of hertz. To improve the performance, a linear MOSFET regulation system using paralleled MOSFET devices in series with the power supply is proposed. The system uses a realtime current feedback loop to force the MOSFETs to work in the linear operation mode. By using this linear MOSFET regulator, the voltage drop on MOSFETs, and hence the voltage imposed on magnets, can be regulated very quickly. As a result, the regulation of the magnet current can be improved significantly. So far the simulation results show that with the linear regulator, the current regulation can be improved to better than 0.1%. Because of the high bandwidth of the linear regulator, it can reduce the harmonic content in the output current as well as reject the AC line disturbance. This paper discusses the circuit topology, the regulation method, and the simulation results.

  1. Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and ?-catenin signaling pathway

    SciTech Connect (OSTI)

    Li, Hongzhong; Huang, Jing; Yang, Bing; Xiang, Tingxiu; Yin, Xuedong; Peng, Weiyan; Cheng, Wei; Wan, Jingyuan; Luo, Fuling; Li, Hongyuan; Ren, Guosheng

    2013-10-01

    Although mangiferin which is a naturally occurring glucosylxanthone has exhibited promising anticancer activities, the detailed molecular mechanism of mangiferin on cancers still remains enigmatic. In this study, the anticancer activity of mangiferin was evaluated in breast cancer cell line-based in vitro and in vivo models. We showed that mangiferin treatment resulted in decreased cell viability and suppression of metastatic potential in breast cancer cells. Further mechanistic investigation revealed that mangiferin induced decreased matrix metalloproteinase (MMP)-7 and -9, and reversal of epithelialmesenchymal transition (EMT). Moreover, it was demonstrated that mangiferin significantly inhibited the activation of ?-catenin pathway. Subsequent experiments showed that inhibiting ?-catenin pathway might play a central role in mangiferin-induced anticancer activity through modulation of MMP-7 and -9, and EMT. Consistent with these findings in vitro, the antitumor potential was also verified in mangiferin-treated MDA-MB-231 xenograft mice where significantly decreased tumor volume, weight and proliferation, and increased apoptosis were obtained, with lower expression of MMP-7 and -9, vimentin and active ?-catenin, and higher expression of E-cadherin. Taken together, our study suggests that mangiferin might be used as an effective chemopreventive agent against breast cancer. - Highlights: Mangiferin inhibits growth and metastatic potential in breast cancer cells. Mangiferin down-regulates MMP-7 and -9 in breast cancer cells. Mangiferin induces the reversal of EMT in metastatic breast cancer cells. Mangiferin inhibits the activation of ?-catenin pathway in breast cancer cells. Inhibiting ?-catenin is responsible for the antitumor activity of mangiferin.

  2. Regulations, Policies and Strategies for LLRW Management in Bangladesh - 12368

    SciTech Connect (OSTI)

    Mollah, A.S.

    2012-07-01

    Low level radioactive waste (LLW) is generated from various nuclear applications in Bangladesh. The major sources of radioactive waste in the country are at present: (a) the 3 MW TRIGA Mark-II research reactor; (b) the radioisotope production facility; (c) the medical, industrial and research facilities that use radionuclides; and (d) the industrial facility for processing monazite sands. Radioactive waste needs to be safely managed because it is potentially hazardous to human health and the environment. According to Nuclear Safety and Radiation Control Act-93, the Bangladesh Atomic Energy Commission (BAEC) is the governmental body responsible for the receipt and final disposal of radioactive wastes in the whole country. Waste management policy has become an important environmental, social, and economical issue for LLW in Bangladesh. Policy and strategies will serve as a basic guide for radioactive waste management in Bangladesh. The waste generator is responsible for on-site collection, conditioning and temporary storage of the waste arising from his practice. The Central Waste Processing and Storage Unit (CWPSU) of BAEC is the designated national facility with the requisite facility for the treatment, conditioning and storage of radioactive waste until a final disposal facility is established and becomes operational. The Regulatory Authority is responsible for the enforcement of compliance with provisions of the waste management regulation and other relevant requirements by the waste generator and the CWPSU. The objective of this paper is to present, in a concise form, basic information about the radioactive waste management infrastructure, regulations, policies and strategies including the total inventory of low level radioactive waste in the country. For improvement and strengthening in terms of operational capability, safety and security of RW including spent radioactive sources and overall security of the facility (CWPSF), the facility is expected to serve waste management need in the country and, in the course of time, the facility may be turned into a regional level training centre. It is essential for safe conduction and culture of research and application in nuclear science and technology maintaining the relevant safety of man and environment and future generations to come. (authors)

  3. Fast Responding Voltage Regulator and Dynamic VAR Compensator

    SciTech Connect (OSTI)

    Divan, Deepak; Moghe, Rohit; Tholomier, Damien

    2014-12-31

    The objectives of this project were to develop a dynamic VAR compensator (DVC) for voltage regulation through VAR support to demonstrate the ability to achieve greater levels of voltage control on electricity distribution networks, and faster response compared to existing grid technology. The goal of the project was to develop a prototype Fast Dynamic VAR Compensator (Fast DVC) hardware device, and this was achieved. In addition to developing the dynamic VAR compensator device, Varentec in partnership with researchers at North Carolina State University (NCSU) successfully met the objectives to model the potential positive impact of such DVCs on representative power networks. This modeling activity validated the ability of distributed dynamic VAR compensators to provide fast voltage regulation and reactive power control required to respond to grid disturbances under high penetration of fluctuating and intermittent distributed energy resources (DERs) through extensive simulation studies. Specifically the following tasks were set to be accomplished: 1) Development of dynamic VAR compensator to support dynamic voltage variations on the grid through VAR control 2) Extensive testing of the DVC in the lab environment 3) Present the operational DVC device to the DOE at Varentec’s lab 4) Formulation of a detailed specification sheet, unit assembly document, test setup document, unit bring-up plan, and test plan 5) Extensive simulations of the DVC in a system with high PV penetration. Understanding the operation with many DVC on a single distribution system 6) Creation and submittal of quarterly and final reports conveying the design documents, unit performance data, modeling simulation charts and diagrams, and summary explanations of the satisfaction of program goals. This report details the various efforts that led to the development of the Fast DVC as well as the modeling & simulation results. The report begins with the introduction in Section II which outlines the problems associated with increasing penetration of renewable resources on the grid and what are the challenges in solving these issues. Section III provides a brief summary of the initial concepts that were explored before the final Fast DVC prototype was developed. Section IV and V present the hardware, controls, communication, and mechanical architecture and features of the Fast DVC. Section VI presents the procedure for assembling the Fast DVC. The test plan and lab setup are expounded in Section VII and VIII. Section IX presents the results from testing the Fast DVC in the lab, several results are presented along with some pictures of the developed unit. Section X details the pilot demonstration activities. Finally, section XI showcases the efforts associated with the simulation and modeling of the Fast DVC in various scenarios with DERs and its impact in all these scenarios.

  4. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Texas. Preliminary background report

    SciTech Connect (OSTI)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities in Texas is generally vested in the Public Utilities Commission. The Commission is comprised of three members appointed by the governor, with the advice of at least two-thirds of the senate, for a six-year term. Prior to the passage of the Texas Public Utility Regulatory Act (PURA) in 1975, the power to regulate public utilities was vested almost exclusively in municipalities. Under PURA, municipalities retain exclusive original jurisdiction over all electric, water, and sewer utilities within the municipality. PURA provides that all regulations pertaining to public utilities promulgated by local regulatory agencies remain in effect unless they are superceded by Commission rules. The municipality's governing body is required to exercise its regulatory authority under rules and standards consistent with those promulgated by the Commission. The Commission has exclusive appellate jurisdiction to review orders and ordinances of regulatory municipalities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  5. Notification of Concurrence - K-25/K-27 D&D Project, ETTP - Change Number of EMWMF Waste Lots in the Waste Handling Plan for Demolition of the K-25 and K-27 Building Structures and Remaining Components Located at the ETTP, Oak Ridge, TN From Two to Three

    SciTech Connect (OSTI)

    Trice K.D.

    2009-02-11

    Section 5.1 of the approved Waste Handling Plan for Demolition ofthe K-25 and K-2 7 Building Structures and Remaining Components Located at the East Tennessee Technology Park, Oak Ridge, Tennessee (WHP) includes two Environmental Management Waste Management (EMWMF) waste lots: (1) Asbestos-contaminated roofing/transite; and (2) Construction debris, such as nonasbestos roofing, structural steel/miscellaneous metal/equipment, nonradiological piping, wood, and miscellaneous small quantities of concrete. This concurrence form adds an additional EMWMF waste lot 6.47 for lavatory sink drains. Based on an analysis of the building structure characterization data, the only individual building structure with either an analytic carcinogenic or Hazard Index (HI) sum-of-fractions (SOF) greater than 1 is the lavatory sink drains (Table 1). The HI SOF for the lavatory sink drains is 1.34 (Table 2). When all media are combined with the material of construction calculations, the HI SOF is 1.22 (Table 3). However, when the lavatory sink drains are segregated from all other media, the HI SOF is only 0.256, which is well below the EMWMF waste acceptance criteria SOF limit of 1 (Table 4). Given the large volume (124, 625 cubic yards) of other building structure media with a small HI SOF of 0.256 and the small volume (one cubic yard) of lavatory sink drains with a large HI SOF of 1.34, a separate waste lot for lavatory sink drains is recommended. Lead is the primary contributor to the large HI SOF in the lavatory sink drains. Lead in the lavatory sink drains was shown using the Wilcoxon rank-sum test statistically to have higher concentrations than all other building structure media combined. Other analytes having statistically different median concentrations in the lavatory sink drains compared to all other media are antimony, arsenic, boron, cadmium, selenium, solver, vanadium, zinc, mercury, strontium, and Uranium-233/234 (Table 5). A separate waste lot for the lavatory sink drains minimizes the volume weighted sum-of fractions since a much smaller volume of waste will have the higher HI SOF of 1.34, while a much larger volume of waste will have a small HI SOF of 0.256.

  6. HDAC3 regulates stability of estrogen receptor ? mRNA

    SciTech Connect (OSTI)

    Oie, Shohei; Matsuzaki, Kazuya; Yokoyama, Wataru; Murayama, Akiko; Yanagisawa, Junn

    2013-03-08

    Highlights: ? HDAC inhibitors decrease the stability of ER? mRNA in MCF-7 cells. ? HDAC3 is involved in maintaining ER? mRNA stability in MCF-7 cells. ? ER? mRNA instability by knockdown of HDAC3 reduces the estrogen-dependent proliferation of ER?-positive MCF-7 cells. ? HDAC3 specific inhibitor will be one of new drugs for ER?-positive breast cancers. -- Abstract: Estrogen receptor alpha (ER?) expression is a risk factor for breast cancer. HDAC inhibitors have been demonstrated to down-regulate ER? expression in ER?-positive breast cancer cell lines, but the molecular mechanisms are poorly understood. Here, we showed that HDAC inhibitors decrease the stability of ER? mRNA, and that knockdown of HDAC3 decreases the stability of ER? mRNA and suppresses estrogen-dependent proliferation of ER?-positive MCF-7 breast cancer cells. In the Oncomine database, expression levels of HDAC3 in ER?-positive tumors are higher than those in ER?-negative tumors, thus suggesting that HDAC3 is necessary for ER? mRNA stability, and is involved in the estrogen-dependent proliferation of ER?-positive tumors.

  7. Federal program for regulating highly hazardous materials finally takes off

    SciTech Connect (OSTI)

    Lessard, P.C. [Block Environmental Services Inc., Pleasant Hill, CA (United States)

    1996-11-01

    The Risk Management Program (RMP) rule, Section 112(r) of the Clean Air Act (CAA), was signed on May 24 and finalized on June 20. RMP is one of the most comprehensive, technically based regulatory programs for preventing, detecting and responding to accidental hazardous materials releases to have been issued in recent times. Although facilities have three years to comply, EPA estimates that the rule will affect an estimated 66,000 facilities that store highly hazardous or acutely toxic materials. The 1990 CAA Amendments are designed to prevent accidental releases of highly hazardous chemicals from stationary sources. Two significant regulatory programs that have emerged from the revised CAA are the Process Safety Management (PSM) standard and RMP. PSM is designed to protect employees and regulated by the Occupational Safety and Health Administration. RMP`s purpose is to protect the public and the environment from highly hazardous chemicals. It authorizes EPA to create a list of substances (distinct from the list generated under PSM) known to cause serious adverse effects and to implement a program for accidental chemical release prevention.

  8. Fact Sheet: Beacon Power 20 MW Flywheel Frequency Regulation Plant (August

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2013) | Department of Energy Beacon Power 20 MW Flywheel Frequency Regulation Plant (August 2013) Fact Sheet: Beacon Power 20 MW Flywheel Frequency Regulation Plant (August 2013) Beacon Power will design, build, and operate a utility-scale 20 MW flywheel energy storage plant at the Humboldt Industrial Park in Hazle Township, PA for Hazle Spindle LLC. The plant will provide frequency regulation services to grid operator PJM Interconnection. For more information about how OE performs research

  9. System and method for regulating EGR cooling using a rankine cycle

    DOE Patents [OSTI]

    Ernst, Timothy C.; Morris, Dave

    2015-12-22

    This disclosure relates to a waste heat recovery (WHR) system and method for regulating exhaust gas recirculation (EGR) cooling, and more particularly, to a Rankine cycle WHR system and method, including a recuperator bypass arrangement to regulate EGR exhaust gas cooling for engine efficiency improvement and thermal management. This disclosure describes other unique bypass arrangements for increased flexibility in the ability to regulate EGR exhaust gas cooling.

  10. Methods, systems and apparatus for synchronous current regulation of a five-phase machine

    DOE Patents [OSTI]

    Gallegos-Lopez, Gabriel; Perisic, Milun

    2012-10-09

    Methods, systems and apparatus are provided for controlling operation of and regulating current provided to a five-phase machine when one or more phases has experienced a fault or has failed. In one implementation, the disclosed embodiments can be used to synchronously regulate current in a vector controlled motor drive system that includes a five-phase AC machine, a five-phase inverter module coupled to the five-phase AC machine, and a synchronous current regulator.

  11. Improving the regulation of safety at DOE nuclear facilities. Final report

    SciTech Connect (OSTI)

    1995-12-01

    The report strongly recommends that, with the end of the Cold War, safety and health at DOE facilities should be regulated by outside agencies rather than by DOE itself. The three major recommendations are: under any regulatory scheme, DOE must maintain a strong internal safety management system; essentially all aspects of safety at DOE`s nuclear facilities should be externally regulated; and existing agencies rather than a new one should be responsible for external regulation.

  12. Improving the regulation of safety at DOE nuclear facilities. Final report: Appendices

    SciTech Connect (OSTI)

    1995-12-01

    The report strongly recommends that, with the end of the Cold War, safety and health at DOE facilities should be regulated by outside agencies rather than by any regulatory scheme, DOE must maintain a strong internal safety management system; essentially all aspects of safety at DOE`s nuclear facilities should be externally regulated; and existing agencies rather than a new one should be responsible for external regulation.

  13. Colorado Code of Regulations 2 CCR 601-18, State Utility Accommodation...

    Open Energy Info (EERE)

    Colorado Code of Regulations 2 CCR 601-18, State Utility Accommodation Code (Redirected from CDOT - Rules Pertaining to Accommodating Utilities in the State Highway Rights of Way)...

  14. New York State`s regulations for low-level radioactive waste disposal facilities

    SciTech Connect (OSTI)

    Youngberg, B.; Merges, P.; Owen, K.

    1994-12-31

    The New York State Department of Environmental Conservation`s (NYSDEC) regulations for low-level radioactive waste (LLRW) disposal facilities set primarily performance-based criteria for LLRW disposal facilities. The regulations (Part 383 of Title 6 of the New York State Codes of Rules and Regulations) set requirements for design, construction, operation, monitoring, site safety planning, financial assurance, closure, post closure monitoring and maintenance, and institutional control. The regulations are unique in their detail and in presenting specific requirements for below ground disposal units, above ground disposal units, and underground mined repositories.

  15. Code of Colorado Regulations 5 CCR 1002-61, Colorado Discharge...

    Open Energy Info (EERE)

    Code of Colorado Regulations 5 CCR 1002-61, Colorado Discharge Permit System Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document-...

  16. 33 CFR Part 221 USACE Regulations for Work for Others | Open...

    Open Energy Info (EERE)

    Abstract This Part of the US Army Corps of Engineers' regulations provides procedures for working with other agencies including, processes for cooperating with FERC when...

  17. Is Tritium over-regulated by DOE? Should the TFG support NA-1 SD G 1027

    Office of Environmental Management (EM)

    tritium values? | Department of Energy over-regulated by DOE? Should the TFG support NA-1 SD G 1027 tritium values? Is Tritium over-regulated by DOE? Should the TFG support NA-1 SD G 1027 tritium values? Presentation from the 32nd Tritium Focus Group Meeting held in Germantown, Maryland on April 23-25, 2013. PDF icon Is Tritium over-regulated by DOE? Should the TFG support NA-1 SD G 1027 tritium values? More Documents & Publications Is Tritium Over-Regulated, Part 2 Should The TFG

  18. Acquisition Guide Chapter 1.1- Acquisition Regulations System- (March 2004)

    Broader source: Energy.gov [DOE]

    This section discusses the Civilian Agency Acquisition Council, agency acquisition regulations, deviations from the FAR and DEAR, ratification of unauthorized commitments, and Contracting Officers and their representatives.

  19. Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency

    Broader source: Energy.gov [DOE]

    The Office of the Assistant General Counsel for Legislation, Regulation and Energy Efficiency (GC-33) provides legal support and advice on legislative matters throughout the Department. It...

  20. REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST...

    Office of Scientific and Technical Information (OSTI)

    REGULATION OF CARBON SEQUESTRATION AND WATER USE IN A OZARK FOREST: PROPOSING A NEW STRATEGICALLY LOCATED AMERIFLUX TOWER SITE IN MISSOURI Pallardy, Stephen G 59 BASIC BIOLOGICAL...

  1. Survey of environmental regulations applying to geothermal exploration, development, and use.

    SciTech Connect (OSTI)

    Beeland, G.V.

    1984-03-01

    Federal, State, and local environmental laws and regulations that apply to geothermal energy development are summarized. Most attention is given to those regulations which deal with air pollution, water pollution, solid wastes and impact assessments. Analyses are made of the regulations with respect to resource definition, pollutants currently not controlled, duplicity and overlap in permit and impact assessment requirements, the lack of uniformity of regulations between states, and the probable future approaches to the regulatory problems. This project updates a similar document (EPA/600/7-78-014) dated February 1978.

  2. Smart Grid Newsletter …TheRegulators Role in Grid ModernizationŽ or Leadership from State Regulators can make the Smart G

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Title: "The Regulator's Role in Grid Modernization" Sponsor: The Modern Grid Strategy is a DOE-funded project conducted by the National Energy Technology Laboratory Leadership from state regulators can make the Smart Grid a reality In previous articles we discussed the principal characteristics that define a Modern (Smart) Grid. Armed with a much clearer understanding of what is a modern grid, and what technologies it will employ, we can now address a number of less technical issues.

  3. Implications of a stochastic approach to air-quality regulations

    SciTech Connect (OSTI)

    Witten, A.J.; Kornegay, F.C.; Hunsaker, D.B. Jr.; Long, E.C. Jr.; Sharp, R.D.; Walsh, P.J.; Zeighami, E.A.; Gordon, J.S.; Lin, W.L.

    1982-09-01

    This study explores the viability of a stochastic approach to air quality regulations. The stochastic approach considered here is one which incorporates the variability which exists in sulfur dioxide (SO/sub 2/) emissions from coal-fired power plants. Emission variability arises from a combination of many factors including variability in the composition of as-received coal such as sulfur content, moisture content, ash content, and heating value, as well as variability which is introduced in power plant operations. The stochastic approach as conceived in this study addresses variability by taking the SO/sub 2/ emission rate to be a random variable with specified statistics. Given the statistical description of the emission rate and known meteorological conditions, it is possible to predict the probability of a facility exceeding a specified emission limit or violating an established air quality standard. This study also investigates the implications of accounting for emissions variability by allowing compliance to be interpreted as an allowable probability of occurrence of given events. For example, compliance with an emission limit could be defined as the probability of exceeding a specified emission value, such as 1.2 lbs SO/sub 2//MMBtu, being less than 1%. In contrast, compliance is currently taken to mean that this limit shall never be exceeded, i.e., no exceedance probability is allowed. The focus of this study is on the economic benefits offered to facilities through the greater flexibility of the stochastic approach as compared with possible changes in air quality and health effects which could result.

  4. Volume regulation by human lymphocytes. Role of calcium

    SciTech Connect (OSTI)

    Grinstein, S.; Dupre, A.; Rothstein, A.

    1982-05-01

    Human peripheral blood lymphocytes regulate their volumes in hypotonic solutions. In hypotonic media in which Na+ is the predominant cation, an initial swelling phase is followed by a regulatory volume decrease (RVD) associated with a net loss of cellular K+. In media in which K+ is the predominant cation, the rapid initial swelling is followed by a slower second swelling phase. /sup 86/Rb+ fluxes increased during RVD and returned to normal when the original volume was approximately regained. Effects similar to those induced by hypotonic stress could also be produced by raising the intracellular Ca++ level. In isotonic, Ca++-containing media cells were found to shrink upon addition of the Ca++ ionophore A23187 in K+-free media, but to swell in K+-rich media. Exposure to Ca++ plus A23187 also increased /sup 86/Rb+ fluxes. Quinine (75 microM), an inhibitor of the Ca++-activated K+ pathway in other systems blocked RVD, the associated K+ loss, and the increase in /sup 86/Rb+ efflux. Quinine also inhibited the volume changes and the increased /sup 86/Rb fluxes induced by Ca++ plus ionophore. The calmodulin inhibitors trifluoperazine, pimozide and chlorpromazine blocked RVD as well as Ca++ plus A23187-induced volume changes. Trifluoperazine also prevented the increase in /sup 86/Rb+ fluxes and K+ loss induced by hypotonicity. Chlorpromazine sulfoxide, a relatively ineffective calmodulin antagonist, was considerably less potent as an inhibitor of RVD than chlorpromazine. It is suggested than an elevation in cytoplasmic (Ca++), triggered by cell swelling, increases the plasma membrane permeability to K+, the ensuing increased efflux of K+, associated anions, and osmotically obliged water, leading to cell shrinking (RVD).

  5. Brassinosteroid regulated kinases (BRKs) that mediate brassinosteroid signal transduction and uses thereof

    DOE Patents [OSTI]

    Wang, Zhi-Yong; Tang, Wenqiang

    2013-09-24

    The present invention identifies a novel family of kinases regulated by brassinosteroids, referred to as BRKs (brassinosteroid regulated kinases) or BSKs (brassinosteroid signaling kinases). The present invention provides methods for modulating the response of a plant cell to a brassinosteroid using BRKs.

  6. Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR alpha

    SciTech Connect (OSTI)

    Genoux, Annelise; Dehondt, Helene; Helleboid-Chapman, Audrey; Duhem, Christian; Hum, Dean W.; Martin, Genevieve; Pennacchio, Len; Staels, Bart; Fruchart-Najib, Jamila; Fruchart, Jean-Charles

    2004-10-01

    Apolipoprotein A5 has recently been identified as a crucial determinant of plasma triglyceride levels. Our results showed that RORa up-regulates human APOA5 but has no effect on mouse apoa5 promoter. These data suggest an additional important physiological role for RORa in the regulation of genes involved in plasma triglyceride homeostasis in human and probably in the development of atherosclerosis

  7. Impact of federal regulations on the small coal mine in Appalachia. Final report

    SciTech Connect (OSTI)

    Davis, B.; Ferrell, R.

    1980-11-01

    This report contains the results of a study of the total costs of compliance with federal regulations of coal mines in Eastern Kentucky. The mines were stratified by tonnage per year and employment. Mail and personal interview surveys were conducted for each stratum. Survey results attempt to suggest the competitive position of small concerns and to form a basis for necessary modifications in regulations.

  8. The impact of environmental regulation on productivity in the US fossil-fueled power plants

    SciTech Connect (OSTI)

    Whang, J.

    1993-12-31

    The purpose of this dissertation is to examine the impact of environmental regulation on productivity in the U.S. fossil fueled electric generating industry. With the oil shocks, environmental regulation has been considered as one of the main culprits for the apparent productivity slowdown during the 1970`s. Even though new pieces of legislation are continuously enacted to regulate hazardous pollutants emitted, it is difficult to find thorough and meaningful analyses on the effects of regulation. Without exact measurement of regulation effects, it is not easy to design socially efficient environmental policies to reconcile several conflicting goals. Using plant-level production and environmental data for the last two decades, the effects of differentiated environmental regulation are carefully examined. Since unbalanced panel data set is used, fixed-effects and random-effects models are also examined. The estimated impact of environmental regulation explains 6 to 10 percent of the variation of total factor productivity growth rates. This appears to be a relatively mild effect compared with several previous studies.

  9. Regulation of store-operated Ca{sup 2+} entry activity by cell cycle dependent up-regulation of Orai2 in brain capillary endothelial cells

    SciTech Connect (OSTI)

    Kito, Hiroaki; Yamamura, Hisao; Suzuki, Yoshiaki; Yamamura, Hideto; Ohya, Susumu; Asai, Kiyofumi; Imaizumi, Yuji

    2015-04-10

    Store-operated Ca{sup 2+} entry (SOCE) via Orai1 and STIM1 complex is supposed to have obligatory roles in the regulation of cellular functions of vascular endothelial cells, while little is known about the contribution of Orai2. Quantitative PCR and Western blot analyses indicated the expression of Orai2 and STIM2, in addition to Orai1 and STIM1 in bovine brain capillary endothelial cell line, t-BBEC117. During the exponential growth of t-BBEC117, the knockdown of Orai1 and STIM1 significantly reduced the SOCE activity, whereas Orai2 and STIM2 siRNAs had no effect. To examine whether endogenous SOCE activity contributes to the regulation of cell cycle progression, t-BBEC117 were synchronized using double thymidine blockage. At the G2/M phase, Ca{sup 2+} influx via SOCE was decreased and Orai2 expression was increased compared to the G0/G1 phase. When Orai2 was knocked down at the G2/M phase, the decrease in SOCE was removed, and cell proliferation was partly attenuated. Taken together, Orai1 significantly contributes to cell proliferation via the functional expression, which is presumably independent of the cell cycle phases. In construct, Orai2 is specifically up-regulated during the G2/M phase, negatively modulates the SOCE activity, and may contribute to the regulation of cell cycle progression in brain capillary endothelial cells. - Highlights: • Orai1 is essential for SOCE activity in brain capillary endothelial cells (BCECs). • Cell cycle independent expression of Orai1 regulated SOCE and cell proliferation. • Orai2 was up-regulated only at G2/M phase and this consequently reduced SOCE. • Orai2 as well as Orai1 is a key player controlling SOCE and proliferation in BCECs.

  10. Coordinated Regulation of Virulence during Systemic Infection of Salmonella enterica serovar Typhimurium

    SciTech Connect (OSTI)

    Yoon, Hyunjin; McDermott, Jason E.; Porwollik, Steffen; Mcclelland, Michael; Heffron, Fred

    2009-02-20

    Salmonella must respond to a myriad of environmental cues during infection of a mouse and express specific subsets of genes in a temporal and spatial manner to subvert the host defense mechanisms but these regulatory pathways are poorly established. To unravel how micro-environmental signals are processed and integrated into coordinated action, we constructed in-frame non-polar deletions of 84 regulators inferred to play a role in Salmonella typhimurium virulence and tested them in three virulence assays (intraperitoneal (i.p.), and intragastric (i.g.) infection in BALB/c mice, and persistence in SvJ129 mice). Overall 36 regulators were identified that were less virulent in at least one assay, and of those, 15 regulators were required for systemic mouse infection in an acute infection model. As a first step towards understanding the interplay between a pathogen and its host from a systems biology standpoint we focused on these 15 genes. Transcriptional profiles were obtained for each of these 15 regulators from strains grown under four different environmental conditions. These results as well as publicly available transcriptional profiles were analyzed using both network inference and cluster analysis algorithms. The analysis predicts a regulatory network in which all 15 regulators control a specific set of genes necessary for Salmonella to cause systemic infection. We tested the regulatory model by expressing a subset of the regulators in trans and monitoring transcription of 7 known virulence factors located within Salmonella pathogenicity island 2 (SPI-2). These experiments validated the regulatory model and showed that, for these 7 genes, the response regulator SsrB and the marR type regulator SlyA co-regulate in a regulatory cascade by integrating multiple signals.

  11. Regulation of brain copper homeostasis by the brain barrier systems: Effects of Fe-overload and Fe-deficiency

    SciTech Connect (OSTI)

    Monnot, Andrew D.; Behl, Mamta; Ho, Sanna; Zheng, Wei

    2011-11-15

    Maintaining brain Cu homeostasis is vital for normal brain function. The role of systemic Fe deficiency (FeD) or overload (FeO) due to metabolic diseases or environmental insults in Cu homeostasis in the cerebrospinal fluid (CSF) and brain tissues remains unknown. This study was designed to investigate how blood-brain barrier (BBB) and blood-SCF barrier (BCB) regulated Cu transport and how FeO or FeD altered brain Cu homeostasis. Rats received an Fe-enriched or Fe-depleted diet for 4 weeks. FeD and FeO treatment resulted in a significant increase (+ 55%) and decrease (- 56%) in CSF Cu levels (p < 0.05), respectively; however, neither treatment had any effect on CSF Fe levels. The FeD, but not FeO, led to significant increases in Cu levels in brain parenchyma and the choroid plexus. In situ brain perfusion studies demonstrated that the rate of Cu transport into the brain parenchyma was significantly faster in FeD rats (+ 92%) and significantly slower (- 53%) in FeO rats than in controls. In vitro two chamber Transwell transepithelial transport studies using primary choroidal epithelial cells revealed a predominant efflux of Cu from the CSF to blood compartment by the BCB. Further ventriculo-cisternal perfusion studies showed that Cu clearance by the choroid plexus in FeD animals was significantly greater than control (p < 0.05). Taken together, our results demonstrate that both the BBB and BCB contribute to maintain a stable Cu homeostasis in the brain and CSF. Cu appears to enter the brain primarily via the BBB and is subsequently removed from the CSF by the BCB. FeD has a more profound effect on brain Cu levels than FeO. FeD increases Cu transport at the brain barriers and prompts Cu overload in the CNS. The BCB plays a key role in removing the excess Cu from the CSF.

  12. Wind/PV Generation for Frequency Regulation and Oscillation Damping in the Eastern Interconnection

    SciTech Connect (OSTI)

    Liu, Yong; Gracia, Jose R; Hadley, Stanton W; Liu, Yilu

    2013-12-01

    This report presents the control of renewable energy sources, including the variable-speed wind generators and solar photovoltaic (PV) generators, for frequency regulation and inter-area oscillation damping in the U.S. Eastern Interconnection (EI). In this report, based on the user-defined wind/PV generator electrical control model and the 16,000-bus Eastern Interconnection dynamic model, the additional controllers for frequency regulation and inter-area oscillation damping are developed and incorporated and the potential contributions of renewable energy sources to the EI system frequency regulation and inter-area oscillation damping are evaluated.

  13. Market effects of environmental regulation: coal, railroads, and the 1990 Clean Air Act

    SciTech Connect (OSTI)

    Busse, M.R.; Keohane, N.O.

    2007-01-01

    Many environmental regulations encourage the use of 'clean' inputs. When the suppliers of such an input have market power, environmental regulation will affect not only the quantity of the input used but also its price. We investigate the effect of the Title IV emissions trading program for sulfur dioxide on the market for low-sulfur coal. We find that the two railroads transporting coal were able to price discriminate on the basis of environmental regulation and geographic location. Delivered prices rose for plants in the trading program relative to other plants, and by more at plants near a low-sulfur coal source.

  14. Update on State Air Emission Regulations That Affect Electric Power Producers (released in AEO2005)

    Reports and Publications (EIA)

    2005-01-01

    Several states have recently enacted air emission regulations that will affect the electricity generation sector. The regulations are intended to improve air quality in the states and assist them in complying with the revised 1997 National Ambient Air Quality Standards (NAAQS) for ground-level ozone and fine particulates. The affected states include Connecticut, Massachusetts, Maine, Missouri, New Hampshire, New Jersey, New York, North Carolina, Oregon, Texas, and Washington. The regulations govern emissions of NOx, SO2, CO2, and mercury from power plants.

  15. ORS 517.705 Exploration Permit Regulations for Mining and Mining...

    Open Energy Info (EERE)

    .705 Exploration Permit Regulations for Mining and Mining Claims Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: ORS 517.705...

  16. DOE specification: Valve-regulated type lead-acid storage batteries

    SciTech Connect (OSTI)

    1996-08-01

    This document contains a ``fill-in-the-blanks`` guide specification for procurement of sealed valve-regulated type lead-acid storage batteries, for uninterruptible power supply applications.

  17. Structural insight into the regulation of MOF in the male-specific...

    Office of Scientific and Technical Information (OSTI)

    Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex Citation Details In-Document Search Title: Structural insight ...

  18. Isolated yeast promoter sequence and a method of regulated heterologous expression

    DOE Patents [OSTI]

    Gao, Johnway; Skeen, Rodney S.; Hooker, Brian S.; Anderson, Daniel B.

    2005-05-31

    The present invention provides the promoter clone discovery of a glucoamylase gene of a starch utilizing yeast strain Schwanniomyces castellii. The isolated glucoamylase promoter is an inducible promoter, which can regulate strong gene expression in starch culture medium.

  19. Title 18 CFR 292 Regulations Under Sections 201 and 210 of the...

    Open Energy Info (EERE)

    Act of 1978 With Regard to Small Power Production and Cogeneration, Forms under Title 18: Conservation of Power and Water Resources of the U.S. Code of Federal Regulations, current...

  20. Title 16 USC 796 Regulation of the Development of Water Power...

    Open Energy Info (EERE)

    6 Regulation of the Development of Water Power and Resources Definitions Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Title 16...