National Library of Energy BETA

Sample records for regulation induced climate

  1. Emission Regulations Reduced Impact of Climate Change in CA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Emission Regulations Reduced Impact of Climate Change in CA Emission Regulations Reduced Impact of Climate Change in CA Study shows clean diesel programs slashed black carbon, a powerful short-term contributor to global warming June 13, 2013 Jon Weiner 510-486-4014 jrweiner@lbl.gov CA-BC-graphic.jpg Sacramento - Reductions in emissions of black carbon since the late 1980s, mostly from diesel engines as a result of air quality programs, have resulted in a measurable reduction of concentrations of

  2. Research on Greenhouse-Gas-Induced Climate Change

    SciTech Connect (OSTI)

    Schlesinger, M. E.

    2001-07-15

    During the 5 years of NSF grant ATM 95-22681 (Research on Greenhouse-Gas-Induced Climate Change, $1,605,000, 9/15/1995 to 8/31/2000) we have performed work which we are described in this report under three topics: (1) Development and Application of Atmosphere, Ocean, Photochemical-Transport, and Coupled Models; (2) Analysis Methods and Estimation; and (3) Climate-Change Scenarios, Impacts and Policy.

  3. Human-Induced Climate Change Reduces Chance of Flooding in Okavango...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human-Induced Climate Change Reduces Chance of Flooding in Okavango Delta Human-Induced Climate Change Reduces Chance of Flooding in Okavango Delta Africa.gif Why it Matters: The...

  4. Human-induced climate change reduces chance of flooding in Okavango...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human-induced climate change reduces chance of flooding in Okavango Delta Human-induced climate change reduces chance of flooding in Okavango Delta March 27, 2014 University of ...

  5. Emission Regulations Reduced Impact of Climate Change in CA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    It is the first comprehensive regional assessment of the climate impact of black carbon on California. In conducting the study, scientists used computer models and air pollution ...

  6. EEI Presentation: The Utility Challenge 2010-2020- Environmental and Climate Regulation, Legislation and Litigation (October 29, 2010)

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation before the Electricity Advisory Committee, October 29, 2010 on The Utility Challenge 2010-2020: Environmental and Climate Regulation, Legislation and Litigation by the Edison Electric...

  7. Climate Induced Spillover and Implications for U.S. Security.

    SciTech Connect (OSTI)

    Tidwell, Vincent C.; Naugle, Asmeret Bier; Backus, George A.; Lott, Kathryn Marie; Keller, Elizabeth; Kobos, Peter H.; Villa, Daniel

    2015-11-01

    Developing nations incur a greater risk to climate change than the developed world due to poorly managed human/natural resources, unreliable infrastructure and brittle governing/economic institutions. These vulnerabilities often give rise to a climate induced “domino effect” of reduced natural resource production-leading to economic hardship, social unrest, and humanitarian crises. Integral to this cascading set of events is increased human migration, leading to the “spillover” of impacts to adjoining areas with even broader impact on global markets and security. Given the complexity of factors influencing human migration and the resultant spill-over effect, quantitative tools are needed to aid policy analysis. Toward this need, a series of migration models were developed along with a system dynamics model of the spillover effect. The migration decision models were structured according to two interacting paths, one that captured long-term “chronic” impacts related to protracted deteriorating quality of life and a second focused on short-term “acute” impacts of disaster and/or conflict. Chronic migration dynamics were modeled for two different cases; one that looked only at emigration but at a national level for the entire world; and a second that looked at both emigration and immigration but focused on a single nation. Model parameterization for each of the migration models was accomplished through regression analysis using decadal data spanning the period 1960-2010. A similar approach was taken with acute migration dynamics except regression analysis utilized annual data sets limited to a shorter time horizon (2001-2013). The system dynamics spillover model was organized around two broad modules, one simulating the decision dynamics of migration and a second module that treats the changing environmental conditions that influence the migration decision. The environmental module informs the migration decision, endogenously simulating interactions

  8. Climate Induced Changes in Biogenic Emissions: Global Chemical...

    Office of Scientific and Technical Information (OSTI)

    Sponsoring Org: USDOE Country of Publication: United States Language: English Subject: 54 ENVIRONMENTAL SCIENCES; CLIMATIC CHANGE; EMISSION; PLANTS; ANIMALS; GLOBAL ASPECTS; ...

  9. Vegetation regulation on streamflow intra-annual variability through adaption to climate variations

    SciTech Connect (OSTI)

    Ye, Sheng; Li, Hongyi; Li, Shuai; Leung, Lai-Yung R.; Demissie, Yonas; Ran, Qihua; Blschl, Gnter

    2015-12-16

    This study aims to provide a mechanistic explanation of the empirical patterns of streamflow intra-annual variability revealed by watershed-scale hydrological data across the contiguous United States. A mathematical extension of the Budyko formula with explicit account for the soil moisture storage change is used to show that, in catchments with a strong seasonal coupling between precipitation and potential evaporation, climate aridity has a dominant control on intra-annual streamflow variability, but in other catchments, additional factors related to soil water storage change also have important controls on how precipitation seasonality propagates to streamflow. More importantly, use of leaf area index as a direct and indirect indicator of the above ground biomass and plant root system, respectively, reveals the vital role of vegetation in regulating soil moisture storage and hence streamflow intra-annual variability under different climate conditions.

  10. Climate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SunShot Grand Challenge: Regional Test Centers Climate HomeTag:Climate Electricity use by water service sector and county. Shown are electricity use by (a) large-scale ...

  11. Agent Model Development for Assessing Climate-Induced Geopolitical Instability.

    SciTech Connect (OSTI)

    Boslough, Mark B.; Backus, George A.

    2005-12-01

    We present the initial stages of development of new agent-based computational methods to generate and test hypotheses about linkages between environmental change and international instability. This report summarizes the first year's effort of an originally proposed three-year Laboratory Directed Research and Development (LDRD) project. The preliminary work focused on a set of simple agent-based models and benefited from lessons learned in previous related projects and case studies of human response to climate change and environmental scarcity. Our approach was to define a qualitative model using extremely simple cellular agent models akin to Lovelock's Daisyworld and Schelling's segregation model. Such models do not require significant computing resources, and users can modify behavior rules to gain insights. One of the difficulties in agent-based modeling is finding the right balance between model simplicity and real-world representation. Our approach was to keep agent behaviors as simple as possible during the development stage (described herein) and to ground them with a realistic geospatial Earth system model in subsequent years. This work is directed toward incorporating projected climate data--including various C02 scenarios from the Intergovernmental Panel on Climate Change (IPCC) Third Assessment Report--and ultimately toward coupling a useful agent-based model to a general circulation model.3

  12. Human-induced climate change reduces chance of flooding in Okavango Delta

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human-induced climate change reduces chance of flooding in Okavango Delta Human-induced climate change reduces chance of flooding in Okavango Delta March 27, 2014 University of Cape Town: Berkeley Lab / NERSC: Riana Geldenhuys Linda Vu Office Tel: +27 21 650 4846 | Mobile: +27 82 460 5554 Office Tel: +1 510 533 5502 riana.geldenhuys@uct.ac.za lvu@lbl.gov OkavangoDeltainnorthernBotswana.jpg This image is a compilation of three images from Envisat's radar and shows where southwestern Africa's

  13. Research project on CO{sub 2}-induced climate change. Annual progress report, March 1, 1994--February 28, 1995

    SciTech Connect (OSTI)

    Cess, R.D.; Hameed, S.

    1995-01-01

    This summarizes current progress in the research project at SUNY Stony Brook on CO2-induced climate change. Three tasks are described, corresponding to the task categories in the USDOE/PRC CAS cooperative project on climate change. Task 1, led by Dr. Robert Cess, concerns the intercomparison of CO2 related climatic warming in contemporary general circulation models. Task 2, directed by Dr. Sultan Hameed, looks at understanding the natural variability in climatic data and comparing its significant features between observations and model simulations. Task 3, also directed by Dr. Hameed focuses on analysis of historical climate data developed at the institute of Geography of the Chinese Academy of Sciences.

  14. Climate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy Nuclear

  15. Climate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy Nuclear

  16. Climate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy Nuclear

  17. Climate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5 - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy Nuclear

  18. Estimates of the long-term U.S. economic impacts of global climate change-induced drought.

    SciTech Connect (OSTI)

    Ehlen, Mark Andrew; Loose, Verne W.; Warren, Drake E.; Vargas, Vanessa N.

    2010-01-01

    While climate-change models have done a reasonable job of forecasting changes in global climate conditions over the past decades, recent data indicate that actual climate change may be much more severe. To better understand some of the potential economic impacts of these severe climate changes, Sandia economists estimated the impacts to the U.S. economy of climate change-induced impacts to U.S. precipitation over the 2010 to 2050 time period. The economists developed an impact methodology that converts changes in precipitation and water availability to changes in economic activity, and conducted simulations of economic impacts using a large-scale macroeconomic model of the U.S. economy.

  19. MicroRNA Regulation of Ionizing Radiation-Induced Premature Senescence

    SciTech Connect (OSTI)

    Wang Yong; Scheiber, Melissa N.; Neumann, Carola; Calin, George A.; Zhou Daohong

    2011-11-01

    Purpose: MicroRNAs (miRNAs) have emerged as critical regulators of many cellular pathways. Ionizing radiation (IR) exposure causes DNA damage and induces premature senescence. However, the role of miRNAs in IR-induced senescence has not been well defined. Thus, the purpose of this study was to identify and characterize senescence-associated miRNAs (SA-miRNAs) and to investigate the role of SA-miRNAs in IR-induced senescence. Methods and Materials: In human lung (WI-38) fibroblasts, premature senescence was induced either by IR or busulfan (BU) treatment, and replicative senescence was accomplished by serial passaging. MiRNA microarray were used to identify SA-miRNAs, and real-time reverse transcription (RT)-PCR validated the expression profiles of SA-miRNAs in various senescent cells. The role of SA-miRNAs in IR-induced senescence was characterized by knockdown of miRNA expression, using anti-miRNA oligonucleotides or by miRNA overexpression through the transfection of pre-miRNA mimics. Results: We identified eight SA-miRNAs, four of which were up-regulated (miR-152, -410, -431, and -493) and four which were down-regulated (miR-155, -20a, -25, and -15a), that are differentially expressed in both prematurely senescent (induced by IR or BU) and replicatively senescent WI-38 cells. Validation of the expression of these SA-miRNAs indicated that down-regulation of miR-155, -20a, -25, and -15a is a characteristic miRNA expression signature of cellular senescence. Functional analyses revealed that knockdown of miR-155 or miR-20a, but not miR-25 or miR-15a, markedly enhanced IR-induced senescence, whereas ectopic overexpression of miR-155 or miR-20a significantly inhibited senescence induction. Furthermore, our studies indicate that miR-155 modulates IR-induced senescence by acting downstream of the p53 and p38 mitogen-activated protein kinase (MAPK) pathways and in part via regulating tumor protein 53-induced nuclear protein 1 (TP53INP1) expression. Conclusion: Our

  20. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

    SciTech Connect (OSTI)

    Fairman, James Wesley; Wijerathna, Sanath Ranjan; Ahmad, Md Faiz; Xu, Hai; Nakano, Ryo; Jha, Shalini; Prendergast, Jay; Welin, R. Martin; Flodin, Susanne; Roos, Annette; Nordlund, Pr; Li, Zongli; Walz, Thomas; Dealwis, Chris Godfrey

    2011-07-25

    Ribonucleotide reductase (RR) is an {alpha}{sub n}{beta}{sub n} (RR1-RR2) complex that maintains balanced dNTP pools by reducing NDPs to dNDPs. RR1 is the catalytic subunit, and RR2 houses the free radical required for catalysis. RR is allosterically regulated by its activator ATP and its inhibitor dATP, which regulate RR activity by inducing oligomerization of RR1. Here, we report the first X-ray structures of human RR1 bound to TTP alone, dATP alone, TTP-GDP, TTP-ATP, and TTP-dATP. These structures provide insights into regulation of RR by ATP or dATP. At physiological dATP concentrations, RR1 forms inactive hexamers. We determined the first X-ray structure of the RR1-dATP hexamer and used single-particle electron microscopy to visualize the {alpha}{sub 6}-{beta}{beta}'-dATP holocomplex. Site-directed mutagenesis and functional assays confirm that hexamerization is a prerequisite for inhibition by dATP. Our data indicate a mechanism for regulating RR activity by dATP-induced oligomerization.

  1. Structural Basis for Allosteric Regulation of Human Ribonucleotide Reductase by Nucleotide-induced Oligomerization

    SciTech Connect (OSTI)

    J Fairman; S Wijerathna; M Ahmad; H Xu; R nakano; S jha; J Prendergast; R Welin; S Flodin; et al.

    2011-12-31

    Ribonucleotide reductase (RR) is an {alpha}{sub n}{beta}{sub n} (RR1-RR2) complex that maintains balanced dNTP pools by reducing NDPs to dNDPs. RR1 is the catalytic subunit, and RR2 houses the free radical required for catalysis. RR is allosterically regulated by its activator ATP and its inhibitor dATP, which regulate RR activity by inducing oligomerization of RR1. Here, we report the first X-ray structures of human RR1 bound to TTP alone, dATP alone, TTP-GDP, TTP-ATP, and TTP-dATP. These structures provide insights into regulation of RR by ATP or dATP. At physiological dATP concentrations, RR1 forms inactive hexamers. We determined the first X-ray structure of the RR1-dATP hexamer and used single-particle electron microscopy to visualize the {alpha}{sub 6}-{beta}{beta}'-dATP holocomplex. Site-directed mutagenesis and functional assays confirm that hexamerization is a prerequisite for inhibition by dATP. Our data indicate a mechanism for regulating RR activity by dATP-induced oligomerization.

  2. PKC{eta} is a negative regulator of AKT inhibiting the IGF-I induced proliferation

    SciTech Connect (OSTI)

    Shahaf, Galit; Rotem-Dai, Noa; Koifman, Gabriela; Raveh-Amit, Hadas; Frost, Sigal A.; Livneh, Etta

    2012-04-15

    The PI3K-AKT pathway is frequently activated in human cancers, including breast cancer, and its activation appears to be critical for tumor maintenance. Some malignant cells are dependent on activated AKT for their survival; tumors exhibiting elevated AKT activity show sensitivity to its inhibition, providing an Achilles heel for their treatment. Here we show that the PKC{eta} isoform is a negative regulator of the AKT signaling pathway. The IGF-I induced phosphorylation on Ser473 of AKT was inhibited by the PKC{eta}-induced expression in MCF-7 breast adenocarcinoma cancer cells. This was further confirmed in shRNA PKC{eta}-knocked-down MCF-7 cells, demonstrating elevated phosphorylation on AKT Ser473. While PKC{eta} exhibited negative regulation on AKT phosphorylation it did not alter the IGF-I induced ERK phosphorylation. However, it enhanced ERK phosphorylation when stimulated by PDGF. Moreover, its effects on IGF-I/AKT and PDGF/ERK pathways were in correlation with cell proliferation. We further show that both PKC{eta} and IGF-I confer protection against UV-induced apoptosis and cell death having additive effects. Although the protective effect of IGF-I involved activation of AKT, it was not affected by PKC{eta} expression, suggesting that PKC{eta} acts through a different route to increase cell survival. Hence, our studies show that PKC{eta} provides negative control on AKT pathway leading to reduced cell proliferation, and further suggest that its presence/absence in breast cancer cells will affect cell death, which could be of therapeutic value.

  3. Epigenetic regulation leading to induced pluripotency drives cancer development in vivo

    SciTech Connect (OSTI)

    Ohnishi, Kotaro; Semi, Katsunori; Yamada, Yasuhiro

    2014-12-05

    Highlights: • Epigenetic regulation of failed reprogramming-associated cancer cells is discussed. • Similarity between pediatric cancer and reprogramming-associated cancer is discussed. • Concept for epigenetic cancer is discussed. - Abstract: Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by the transient expression of reprogramming factors. During the reprogramming process, somatic cells acquire the ability to undergo unlimited proliferation, which is also an important characteristic of cancer cells, while their underlying DNA sequence remains unchanged. Based on the characteristics shared between pluripotent stem cells and cancer cells, the potential involvement of the factors leading to reprogramming toward pluripotency in cancer development has been discussed. Recent in vivo reprogramming studies provided some clues to understanding the role of reprogramming-related epigenetic regulation in cancer development. It was shown that premature termination of the in vivo reprogramming result in the development of tumors that resemble pediatric cancers. Given that epigenetic modifications play a central role during reprogramming, failed reprogramming-associated cancer development may have provided a proof of concept for epigenetics-driven cancer development in vivo.

  4. Glaciers, ice sheets, and sea level: effect of a CO/sub 2/-induced climatic change

    SciTech Connect (OSTI)

    1985-09-01

    The workshop examined the basic questions of how much water has been exchanged between land ice and ocean during the last century, what is happening now, and, given existing climate-modeling prediction, how much exchange can be expected in the next century. In addition, the evidence for exchange was examined and gaps in that evidence were identified. The report includes the 23 presentations made at the workshop, summarizes the workshop discussion, and presents the Committee's findings and recommendations. Separate abstracts have been prepared for the 23 presentations.

  5. IL-33 inhibits RANKL-induced osteoclast formation through the regulation of Blimp-1 and IRF-8 expression

    SciTech Connect (OSTI)

    Kiyomiya, Hiroyasu; Ariyoshi, Wataru; Okinaga, Toshinori; Kaneuji, Takeshi; Mitsugi, Sho; Sakurai, Takuma; Habu, Manabu; Yoshioka, Izumi; Tominaga, Kazuhiro; and others

    2015-05-01

    Interleukin (IL)-33 is a recently discovered proinflammatory cytokine that belongs to the IL-1 family. Several studies have reported that IL-33 inhibits osteoclast differentiation. However, the mechanism of IL-33 regulation of osteoclastogenesis remains unclear. In the present study, we examined the effect of IL-33 on osteoclast formation in vitro. IL-33 suppressed osteoclast formation in both mouse bone marrow cells and monocyte/macrophage cell line RAW264.7 cells induced by receptor activator of NF-κB ligand (RANKL) and/or macrophage stimulating factor (M-CSF). IL-33 also inhibited the expression of RANKL-induced nuclear factor of activated T-cell cytoplasmic 1 (NFATc1), thereby decreasing the expression of osteoclastogenesis-related marker genes, including Cathepsin K, Osteoclast stimulatory transmembrane protein (Oc-stamp) and Tartrate-resistant acid phosphatase (Trap). Blockage of IL-33-ST2 binding suppressed the IL-33-mediated inhibition of NFATc1. RANKL-induced B-lymphocyte-induced maturation protein-1 (Blimp-1) expression was also suppressed by IL-33, which was followed by the stimulation of anti-osteoclastic genes such as interferon regulatory factor-8 (IRF-8). These results suggest that IL-33-ST2 interactions down-regulate both RANKL-induced NFATc1 activation and osteoclast differentiation via the regulation of Blimp-1 and IRF-8 expression. - Highlights: • IL-33 inhibits RANKL-induced osteoclast formation. • IL-33 has inhibitory effect on the RANKL-induced NFATc1 expression. • IL-33-induced NFATc1 suppression depends on the regulation of Blimp-1 and IRF-8.

  6. Identification and preliminary characterization of global water resource issues which may be affected by CO/sub 2/-induced climate change

    SciTech Connect (OSTI)

    Callaway, J.M.; Cohen, M.L.; Currie, J.W.

    1984-04-01

    The objectives were to: (1) identify, characterize, and define existing or projected regional and global water resource management issues which may be affected by CO/sub 2/-induced climate changes; and (2) develop research priorities for acquiring additional information about the potential effects of a CO/sub 2/-induced climate change on the availability and allocation of freshwater supplies. The research was broken into four work elements: (1) identification of water resource management issues on a global and regional basis; (2) identification of a subset of generic CO/sub 2/-related water resource management issues believed to have the highest probability of being affected, beneficially or adversely, by a CO/sub 2/-induced climate change; (3) selection of specific sites for examining the potential effect of a CO/sub 2/-induced climate change on these issues; and (4) conducting detailed case studies at these sites, the results from which will be used to identify future research and data needs in the area of water resources. This report summarizes the research related to the first three work elements. 6 figures, 9 tables.

  7. Climate & Earth Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human-Induced Climate Change Reduces Chance of Flooding in Okavango Delta Energy Science Engineering Science Environmental Science Fusion Science Math & Computer Science Nuclear...

  8. Effects of soot-induced snow albedo change on snowpack and hydrological cycle in western United States based on Weather Research and Forecasting chemistry and regional climate simulations

    SciTech Connect (OSTI)

    Qian, Yun; Gustafson, William I.; Leung, Lai-Yung R.; Ghan, Steven J.

    2009-02-14

    Radiative forcing induced by soot on snow is a major anthropogenic forcing affecting the global climate. However, it is uncertain how the soot-induced snow albedo perturbation affects regional snowpack and the hydrological cycle. In this study we simulated the deposition of soot aerosol on snow and investigated the resulting impact on snowpack and the surface water budget in the western United States. A yearlong simulation was performed using the chemistry version of the Weather Research and Forecasting model (WRF-Chem) to determine an annual budget of soot deposition, followed by two regional climate simulations using WRF in meteorology-only mode, with and without the soot-induced snow albedo perturbations. The chemistry simulation shows large spatial variability in soot deposition that reflects the localized emissions and the influence of the complex terrain. The soot-induced snow albedo perturbations increase the net solar radiation flux at the surface during late winter to early spring, increase the surface air temperature, reduce snow water equivalent amount, and lead to reduced snow accumulation and less spring snowmelt. These effects are stronger over the central Rockies and southern Alberta, where soot deposition and snowpack overlap the most. The indirect forcing of soot accelerates snowmelt and alters stream flows, including a trend toward earlier melt dates in the western United States. The soot-induced albedo reduction initiates a positive feedback process whereby dirty snow absorbs more solar radiation, heating the surface and warming the air. This warming causes reduced snow depth and fraction, which further reduces the regional surface albedo for the snow covered regions. Our simulations indicate that the change of maximum snow albedo induced by soot on snow contributes to 60% of the net albedo reduction over the central Rockies. Snowpack reduction accounts for the additional 40%.

  9. Bone morphogenic protein-2 regulates the myogenic differentiation of PMVECs in CBDL rat serum-induced pulmonary microvascular remodeling

    SciTech Connect (OSTI)

    Liu, Chang; Chen, Lin; Zeng, Jing; Cui, Jian; Ning, Jiao-nin; Wang, Guan-song; Belguise, Karine; Wang, Xiaobo; Qian, Gui-sheng; Lu, Kai-zhi; Yi, Bin

    2015-08-01

    Hepatopulmonary syndrome (HPS) is characterized by an arterial oxygenation defect induced by intrapulmonary vasodilation (IPVD) that increases morbidity and mortality. In our previous study, it was determined that both the proliferation and the myogenic differentiation of pulmonary microvascular endothelial cells (PMVECs) play a key role in the development of IPVD. However, the molecular mechanism underlying the relationship between IPVD and the myogenic differentiation of PMVECs remains unknown. Additionally, it has been shown that bone morphogenic protein-2 (BMP2), via the control of protein expression, may regulate cell differentiation including cardiomyocyte differentiation, neuronal differentiation and odontoblastic differentiation. In this study, we observed that common bile duct ligation (CBDL)-rat serum induced the upregulation of the expression of several myogenic proteins (SM-α-actin, calponin, SM-MHC) and enhanced the expression levels of BMP2 mRNA and protein in PMVECs. We also observed that both the expression levels of Smad1/5 and the activation of phosphorylated Smad1/5 were significantly elevated in PMVECs following exposure to CBDL-rat serum, which was accompanied by the down-regulation of Smurf1. The blockage of the BMP2/Smad signaling pathway with Noggin inhibited the myogenic differentiation of PMVECs, a process that was associated with relatively low expression levels of both SM-α-actin and calponin in the setting of CBDL-rat serum exposure, although SM-MHC expression was not affected. These findings suggested that the BMP2/Smad signaling pathway is involved in the myogenic differentiation of the PMVECs. In conclusion, our data highlight the pivotal role of BMP2 in the CBDL-rat serum-induced myogenic differentiation of PMVECs via the activation of both Smad1 and Smad5 and the down-regulation of Smurf1, which may represent a potential therapy for HPS-induced pulmonary vascular remodeling. - Highlights: • CBDL-rat serum promotes the myogenic

  10. Climate Perspectives

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Perspectives Climate Perspectives: Change in the Terrestrial Arctic Rising temperatures are rapidly reshaping the terrestrial Arctic. Climate Perspectives: Change in the Terrestrial Arctic is an interactive look at Arctic climate change and climate science through the eyes of scientists and artists. Climate Perspectives slide 1 Climate Perspectives Climate Perspectives is interactive. This slideshow represents a sample of the content within the exhibit. Climate Perspectives slide 2

  11. Transforming growth factor β-activated kinase 1 negatively regulates interleukin-1α-induced stromal-derived factor-1 expression in vascular smooth muscle cells

    SciTech Connect (OSTI)

    Yang, Bin; Li, Wei; Zheng, Qichang; Qin, Tao; Wang, Kun; Li, Jinjin; Guo, Bing; Yu, Qihong; Wu, Yuzhe; Gao, Yang; Cheng, Xiang; Hu, Shaobo; Kumar, Stanley Naveen; Liu, Sanguang; Song, Zifang

    2015-07-17

    Stromal-derived Factor-1 (SDF-1) derived from vascular smooth muscle cells (VSMCs) contributes to vascular repair and remodeling in various vascular diseases. In this study, the mechanism underlying regulation of SDF-1 expression by interleukin-1α (IL-1α) was investigated in primary rat VSMCs. We found IL-1α promotes SDF-1 expression by up-regulating CCAAT-enhancer-binding protein β (C/EBPβ) in an IκB kinase β (IKKβ) signaling-dependent manner. Moreover, IL-1α-induced expression of C/EBPβ and SDF-1 was significantly potentiated by knockdown of transforming growth factor β-activated kinase 1 (TAK1), an upstream activator of IKKβ signaling. In addition, we also demonstrated that TAK1/p38 mitogen-activated protein kinase (p38 MAPK) signaling exerted negative effect on IL-1α-induced expression of C/EBPβ and SDF-1 through counteracting ROS-dependent up-regulation of nuclear factor erythroid 2-related factor 2 (NRF2). In conclusion, TAK1 acts as an important regulator of IL-1α-induced SDF-1 expression in VSMCs, and modulating activity of TAK1 may serve as a potential strategy for modulating vascular repair and remodeling. - Highlights: • IL-1α induces IKKβ signaling-dependent SDF-1 expression by up-regulating C/EBPβ. • Activation of TAK1 by IL-1α negatively regulates C/EBPβ-dependent SDF-1 expression. • IL-1α-induced TAK1/p38 MAPK signaling counteracts ROS-dependent SDF-1 expression. • TAK1 counteracts IL-1α-induced SDF-1 expression by attenuating NRF2 up-regulation.

  12. Response of a tundra ecosytem to elevated atmospheric carbon dioxide and CO{sub 2}-induced climate change. Final report

    SciTech Connect (OSTI)

    Oechel, W.C.

    1996-11-01

    The overall objective of this research was to document current patterns of CO{sub 2} flux in selected locations of the circumpolar arctic, and to develop the information necessary to predict how these fluxes may be affected by climate change. In fulfillment of these objectives, net CO{sub 2} flux was measured at several sites on the North Slope of Alaska during the 1990-94 growing season (June-August) to determine the local and regional patterns, of seasonal CO{sub 2} exchange. In addition, net CO{sub 2} flux was measured in the Russian and Icelandic Arctic to determine if the patterns of CO{sub 2} exchange observed in Arctic Alaska were representative of the circumpolar arctic, while cold-season CO{sub 2} flux measurements were carried out during the 1993-94 winter season to determine the magnitude of CO{sub 2} efflux not accounted for by the growing season measurements. Manipulations of soil water table depth and surface temperature, which were identified from the extensive measurements as being the most important variables in determining the magnitude and direction of net CO{sub 2} exchange, were carried out during the 1993-94 growing seasons in tussock and wet sedge tundra ecosystems. Finally, measurements of CH{sub 4} flux were also measured at several of the North Slope study sites during the 1990-91 growing seasons. Measurements were made on small (e.g. 0.5 m{sup 2}) plots using a portable gas-exchange system and cuvette. The sample design allowed frequent measurements of net CO{sub 2} exchange and respiration over diurnal and seasonal cycles, and a large spatial extent that incorporated both locally and regionally diverse tundra surface types. Measurements both within and between ecosystem types typically extended over soil water table depth and temperature gradients, allowing for the indirect analysis of the effects of anticipated climate change scenarios on net CO{sub 2} exchange. In situ experiments provided a direct means for testing hypotheses.

  13. Response of a tundra ecosystem to elevated atmospheric carbon dioxide and CO{sub 2}-induced climate change. Final report

    SciTech Connect (OSTI)

    Oechel, W.C.

    1996-11-01

    The overall objective of this research was to document current patterns of CO{sub 2} flux in selected locations of the circumpolar arctic, and to develop the information necessary to predict how these fluxes may be affected by climate change. In fulfillment of these objectives, net CO{sub 2} flux was measured at several sites on the North Slope of Alaska during the 1990--94 growing season (June--August) to determine the local and regional patterns of seasonal CO{sub 2} exchange. In addition, net CO{sub 2} flux was measured in the Russian and Icelandic Arctic to determine if the patterns of CO{sub 2} exchange observed in Arctic Alaska were representative of the circumpolar Arctic, while cold-season CO{sub 2} flux measurements were carried out during the 1993--94 winter season to determine the magnitude of CO{sub 2} efflux not accounted for by the growing season measurements. Manipulations of soil water table depth and surface temperature, which were identified from the extensive measurements as being the most important variables in determining the magnitude and direction of net CO{sub 2} exchange, were carried out during the 1993--94 growing seasons in tussock and wet sedge tundra ecosystems. Finally, measurements of CH{sub 4} flux were also measured at several of the North Slope study sites during the 1990--91 growing seasons.

  14. Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis

    SciTech Connect (OSTI)

    Meng, Qiang; Chen, Xin-li; Wang, Chang-yuan; Liu, Qi; Sun, Hui-jun; Sun, Peng-yuan; Huo, Xiao-kui; Liu, Zhi-hao; Yao, Ji-hong; Liu, Ke-xin

    2015-03-15

    Intrahepatic cholestasis is a clinical syndrome with systemic and intrahepatic accumulation of excessive toxic bile acids that ultimately cause hepatobiliary injury. Appropriate regulation of bile acids in hepatocytes is critically important for protection against liver injury. In the present study, we characterized the protective effect of alisol B 23-acetate (AB23A), a natural triterpenoid, on alpha-naphthylisothiocyanate (ANIT)-induced liver injury and intrahepatic cholestasis in mice and further elucidated the mechanisms in vivo and in vitro. AB23A treatment dose-dependently protected against liver injury induced by ANIT through reducing hepatic uptake and increasing efflux of bile acid via down-regulation of hepatic uptake transporters (Ntcp) and up-regulation of efflux transporter (Bsep, Mrp2 and Mdr2) expression. Furthermore, AB23A reduced bile acid synthesis through repressing Cyp7a1 and Cyp8b1, increased bile acid conjugation through inducing Bal, Baat and bile acid metabolism through an induction in gene expression of Sult2a1. We further demonstrate the involvement of farnesoid X receptor (FXR) in the hepatoprotective effect of AB23A. The changes in transporters and enzymes, as well as ameliorative liver histology in AB23A-treated mice were abrogated by FXR antagonist guggulsterone in vivo. In vitro evidences also directly demonstrated the effect of AB23A on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells. In conclusion, AB23A produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes. - Highlights: • AB23A has at least three roles in protection against ANIT-induced liver injury. • AB23A decreases Ntcp, and increases Bsep, Mrp2 and Mdr2 expression. • AB23A represses Cyp7a1 and Cyp8b1 through inducing Shp and Fgf15 expression. • AB23A increases bile acid metabolism through inducing Sult2a1 expression. • FXR activation is involved

  15. Regulation of ozone-induced lung inflammation and injury by the β-galactoside-binding lectin galectin-3

    SciTech Connect (OSTI)

    Sunil, Vasanthi R.; Francis, Mary; Vayas, Kinal N.; Cervelli, Jessica A.; Choi, Hyejeong; Laskin, Jeffrey D.; Laskin, Debra L.

    2015-04-15

    Macrophages play a dual role in ozone toxicity, contributing to both pro- and anti-inflammatory processes. Galectin-3 (Gal-3) is a lectin known to regulate macrophage activity. Herein, we analyzed the role of Gal-3 in the response of lung macrophages to ozone. Bronchoalveolar lavage (BAL) and lung tissue were collected 24–72 h after exposure (3 h) of WT and Gal-3{sup -/-} mice to air or 0.8 ppm ozone. In WT mice, ozone inhalation resulted in increased numbers of proinflammatory (Gal-3{sup +}, iNOS{sup +}) and anti-inflammatory (MR-1{sup +}) macrophages in the lungs. While accumulation of iNOS{sup +} macrophages was attenuated in Gal-3{sup -/-} mice, increased numbers of enlarged MR-1{sup +} macrophages were noted. This correlated with increased numbers of macrophages in BAL. Flow cytometric analysis showed that these cells were CD11b{sup +} and consisted mainly (> 97%) of mature (F4/80{sup +}CD11c{sup +}) proinflammatory (Ly6GLy6C{sup hi}) and anti-inflammatory (Ly6GLy6C{sup lo}) macrophages. Increases in both macrophage subpopulations were observed following ozone inhalation. Loss of Gal-3 resulted in a decrease in Ly6C{sup hi} macrophages, with no effect on Ly6C{sup lo} macrophages. CD11b{sup +}Ly6G{sup +}Ly6C{sup +} granulocytic (G) and monocytic (M) myeloid derived suppressor cells (MDSC) were also identified in the lung after ozone. In Gal-3{sup -/-} mice, the response of G-MDSC to ozone was attenuated, while the response of M-MDSC was heightened. Changes in inflammatory cell populations in the lung of ozone treated Gal-3{sup -/-} mice were correlated with reduced tissue injury as measured by cytochrome b5 expression. These data demonstrate that Gal-3 plays a role in promoting proinflammatory macrophage accumulation and toxicity in the lung following ozone exposure. - Highlights: • Multiple monocytic-macrophage subpopulations accumulate in the lung after ozone inhalation. • Galectin-3 plays a proinflammatory role in ozone-induced lung injury. • In the

  16. Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues

    SciTech Connect (OSTI)

    Tong, Bei; Dou, Yannong; Wang, Ting; Yu, Juntao; Wu, Xin; Lu, Qian; Chou, Guixin; Wang, Zhengtao; Kong, Lingyi; Dai, Yue; Xia, Yufeng

    2015-01-01

    Norisoboldine (NOR), the main active ingredient of the dry root of Lindera aggregata, was previously proven to have substantial therapeutic effects on collagen-induced arthritis (CIA) in mice by oral administration. However, it exhibited a very poor bioavailability in normal rats. The pharmacokinetic–pharmacodynamics disconnection attracts us to explore its anti-arthritic mechanism in more detail. In this study, NOR, administered orally, markedly attenuated the pathological changes in CIA rats, which was accompanied by the down-regulation of pro-inflammatory cytokines and the up-regulation of anti-inflammatory cytokine IL-10. Pharmacokinetic studies demonstrated that the plasma concentration of NOR was moderately elevated in CIA rats compared with normal rats, but it was still far lower than the minimal effective concentration required for inhibiting the proliferation and activation of T lymphocytes in vitro. Interestingly, NOR was shown to regulate the balance between Th17 and regulatory T (Treg) cells in the intestinal lymph nodes more strikingly than in other tissues. It could increase the expression of Foxp3 mRNA in both gut and joints, and markedly up-regulate the number of integrin α4β7 (a marker of gut source)-positive Foxp3{sup +} cells in the joints of CIA rats. These results suggest that the gut might be the primary action site of NOR, and NOR exerts anti-arthritis effect through regulating the balance between Th17 and Treg cells in intestinal lymph nodes and yielding a trafficking of lymphocytes (especially Treg cells) from the gut to joint. The findings of the present study also provide a plausible explanation for the anti-arthritic effects of poorly absorbed compounds like NOR. - Highlights: • Norisoboldine, administered orally, markedly attenuates the clinical signs of CIA. • Norisoboldine regulates the balance of Th17/Treg cells in the intestinal lymph node. • Norisoboldine induces the migration of Treg cells from the gut to joint.

  17. Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

    SciTech Connect (OSTI)

    Kwok, Hoi-Hin; Chan, Lai-Sheung; Poon, Po-Ying; Yue, Patrick Ying-Kit; Wong, Ricky Ngok-Shun

    2015-09-15

    Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by

  18. ARM - Climate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Climate Climate refers to the long-term changes in ...

  19. JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats

    SciTech Connect (OSTI)

    Guo, Xinjin; Meng, Qiang; Liu, Qi; Wang, Changyuan; Sun, Huijun; Peng, Jinyong; Ma, Xiaochi; Kaku, Taiichi; Liu, Kexin

    2013-09-01

    We investigated the effects of JBP485 (an anti-inflammatory dipeptide and a substrate of OAT) on regulation of the expression and function of renal Oat1 and Oat3, which can accelerate the excretion of accumulated uremic toxins (e.g. indoxyl sulfate) in the kidney to improve gentamicin-induced ARF in rats. JBP485 caused a significant decrease in the accumulation of endogenous substances (creatinine, blood urea nitrogen and indoxyl sulfate) in vivo, an increase in the excretion of exogenous compounds (lisinopril and inulin) into urine, and up-regulation of the expressions of renal Oat1 and Oat3 in the kidney tissues and slices via substrate induction. To determine the effect of JBP485 on the accelerated excretion of uremic toxins mediated by Oat1 and Oat3, the mRNA and protein expression levels of renal basolateral Oats were assessed by quantitative real-time PCR, western blot, immunohistochemical analysis and an immunofluorescence method. Gentamicin down-regulated the expression of Oats mRNA and protein in rat kidney, and these effects were reversed after administration of JBP485. In addition, JBP485 caused a significant decrease in MPO and MDA levels in the kidney, and improved the pathological condition of rat kidney. These results indicated that JBP485 improved acute renal failure by increasing the expression and function of Oat1 and Oat3, and by decreasing overoxidation of the kidney in gentamicin-induced ARF rats. - Highlights: • JBP485 could up-regulate function and expression of Oat1 and Oat3 in kidney. • Effects of JBP485 on ARF are mediated by stimulating excretion of uremic toxins. • JBP485 protected against gentamicin-induced ARF by decreasing MPO and MDA.

  20. Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-{kappa}B translocation and ROS production in synoviocytes

    SciTech Connect (OSTI)

    Hu, Fen; Yang, Shuang; Zhao, Dan; Zhu, Shuyan; Wang, Yuxiang; Li, Junying

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Moderate extracellular acidification regulates intracellular Ca{sup 2+} mobilization. Black-Right-Pointing-Pointer Moderate acidification activates NF-{kappa}B nuclear translocation in synoviocytes. Black-Right-Pointing-Pointer Moderate acidification depresses the ROS production induced by capsaicin. Black-Right-Pointing-Pointer Moderate acidification inhibits capsaicin-caused synoviocyte death. -- Abstract: We previously show the expression of transient receptor potential vanilloid 1 (TRPV1) in primary synoviocytes from collagen-induced arthritis (CIA) rats. Capsaicin and lowered extracellular pH from 7.4 to 5.5 induce cell death through TRPV1-mediated Ca{sup 2+} entry and reactive oxygen species (ROS) production. However, under the pathological condition in rheumatoid arthritis, the synovial fluid is acidified to a moderate level (about pH 6.8). In the present study, we examined the effects of pH 6.8 on the TRPV1-mediated cell death. Our finding is different or even opposite from what was observed at pH 5.5. We found that the moderate extracellular acidification (from pH 7.4 to 6.8) inhibited the capsaicin-induced Ca{sup 2+} entry through attenuating the activity of TRPV1. In the mean time, it triggered a phospholipse C (PLC)-related Ca{sup 2+} release from intracellular stores. The nuclear translocation of NF-{kappa}B was found at pH 6.8, and this also depends on PLC activation. Moreover, the capsaicin-evoked massive ROS production and cell death were depressed at pH 6.8, both of which are dependent on the activation of PLC and NF-{kappa}B. Taken together, these results suggested that the moderate extracellular acidification inhibited the capsaicin-induced synoviocyte death through regulating Ca{sup 2+} mobilization, activating NF-{kappa}B nuclear translocation and depressing ROS production.

  1. Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells

    SciTech Connect (OSTI)

    Bustos, Rodrigo I.; Jensen, Erik L.; Ruiz, Lina M.; Rivera, Salvador; Ruiz, Sebastin; Simon, Felipe; Riedel, Claudia; Millennium Institute of Immunology and Immunotherapy, Santiago ; Ferrick, David; Elorza, Alvaro A.

    2013-08-02

    Highlights: In copper deficiency, cell proliferation is not affected. In turn, cell differentiation is impaired. Enlarged mitochondria are due to up-regulation of MNF2 and OPA1. Mitochondria turn off respiratory chain and ROS production. Energy metabolism switch from mitochondria to glycolysis. -- Abstract: Copper is essential in cell physiology, participating in numerous enzyme reactions. In mitochondria, copper is a cofactor for respiratory complex IV, the cytochrome c oxidase. Low copper content is associated with anemia and the appearance of enlarged mitochondria in erythropoietic cells. These findings suggest a connection between copper metabolism and bioenergetics, mitochondrial dynamics and erythropoiesis, which has not been explored so far. Here, we describe that bathocuproine disulfonate-induced copper deficiency does not alter erythropoietic cell proliferation nor induce apoptosis. However it does impair erythroid differentiation, which is associated with a metabolic switch between the two main energy-generating pathways. That is, from mitochondrial function to glycolysis. Switching off mitochondria implies a reduction in oxygen consumption and ROS generation along with an increase in mitochondrial membrane potential. Mitochondrial fusion proteins MFN2 and OPA1 were up-regulated along with the ability of mitochondria to fuse. Morphometric analysis of mitochondria did not show changes in total mitochondrial biomass but rather bigger mitochondria because of increased fusion. Similar results were also obtained with human CD34+, which were induced to differentiate into red blood cells. In all, we have shown that adequate copper levels are important for maintaining proper mitochondrial function and for erythroid differentiation where the energy metabolic switch plus the up-regulation of fusion proteins define an adaptive response to copper deprivation to keep cells alive.

  2. Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury

    SciTech Connect (OSTI)

    Chen, Jiao; Shetty, Sreerama; Zhang, Ping; Gao, Rong; Hu, Yuxin; Wang, Shuxia; Li, Zhenyu; Fu, Jian

    2014-06-01

    The presence of endotoxin in blood can lead to acute kidney injury (AKI) and septic shock. Resolvins, the endogenous lipid mediators derived from docosahexaenoic acid, have been reported to exhibit potent anti-inflammatory action. Using a mouse model of lipopolysaccharide (LPS)-induced AKI, we investigated the effects of aspirin-triggered resolvin D1 (AT-RvD1) on inflammatory kidney injury. Administration of AT-RvD1 1 h after LPS challenge protected the mice from kidney injury as indicated by the measurements of blood urea nitrogen, serum creatinine, and morphological alterations associated with tubular damage. The protective effects were evidenced by decreased neutrophil infiltration in the kidney indicating reduction in inflammation. AT-RvD1 treatment restored kidney cell junction protein claudin-4 expression, which was otherwise reduced after LPS challenge. AT-RvD1 treatment inhibited endotoxin-induced NF-κB activation and suppressed LPS-induced ICAM-1 and VCAM-1 expression in the kidney. Moreover, AT-RvD1 treatment markedly decreased LPS-induced IL-6 level in the kidney and blocked IL-6-mediated signaling including STAT3 and ERK phosphorylation. Our findings demonstrate that AT-RvD1 is a potent anti-inflammatory mediator in LPS-induced kidney injury, and AT-RvD1 has therapeutic potential against AKI during endotoxemia.

  3. Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2

    SciTech Connect (OSTI)

    Eum, Sung Yong Jaraki, Dima; András, Ibolya E.; Toborek, Michal

    2015-09-15

    Occludin is an essential integral transmembrane protein regulating tight junction (TJ) integrity in brain endothelial cells. Phosphorylation of occludin is associated with its localization to TJ sites and incorporation into intact TJ assembly. The present study is focused on the role of lipid rafts in polychlorinated biphenyl (PCB)-induced disruption of occludin and endothelial barrier function. Exposure of human brain endothelial cells to 2,2′,4,4′,5,5′-hexachlorobiphenyl (PCB153) induced dephosphorylation of threonine residues of occludin and displacement of occludin from detergent-resistant membrane (DRM)/lipid raft fractions within 1 h. Moreover, lipid rafts modulated the reduction of occludin level through activation of matrix metalloproteinase 2 (MMP-2) after 24 h PCB153 treatment. Inhibition of protein phosphatase 2A (PP2A) activity by okadaic acid or fostriecin markedly protected against PCB153-induced displacement of occludin and increased permeability of endothelial cells. The implication of lipid rafts and PP2A signaling in these processes was further defined by co-immunoprecipitation of occludin with PP2A and caveolin-1, a marker protein of lipid rafts. Indeed, a significant MMP-2 activity was observed in lipid rafts and was increased by exposure to PCB153. The pretreatment of MMP-2 inhibitors protected against PCB153-induced loss of occludin and disruption of lipid raft structure prevented the increase of endothelial permeability. Overall, these results indicate that lipid raft-associated processes, such as PP2A and MMP-2 activation, participate in PCB153-induced disruption of occludin function in brain endothelial barrier. This study contributes to a better understanding of the mechanisms leading to brain endothelial barrier dysfunction in response to exposure to environmental pollutants, such as ortho-substituted PCBs. - Highlights: • PCB153 disturbed human brain endothelial barrier through disruption of occludin. • Lipid raft-associated PP

  4. Climate Change

    Broader source: Energy.gov [DOE]

    The Energy Department is fighting climate change with research, clean fossil energy technology, domestic renewable energy development and more energy efficient appliances, homes, businesses and vehicles.

  5. Arctic Climate Measurements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable ... Arctic Climate Measurements Global Climate Models Software Sustainable Subsurface ...

  6. Global Climate Models

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable ... Climate & Earth Systems Climate Measurement & Modeling Arctic Climate Measurements Global ...

  7. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect (OSTI)

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  8. EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes

    SciTech Connect (OSTI)

    Han, Sung Gu; Department of Animal and Food Sciences, College of Agriculture, University of Kentucky, Lexington, KY 40536 ; Han, Seong-Su; Toborek, Michal; Hennig, Bernhard; Department of Animal and Food Sciences, College of Agriculture, University of Kentucky, Lexington, KY 40536

    2012-06-01

    Tea flavonoids such as epigallocatechin gallate (EGCG) protect against vascular diseases such as atherosclerosis via their antioxidant and anti-inflammatory functions. Persistent and widespread environmental pollutants, including polychlorinated biphenyls (PCB), can induce oxidative stress and inflammation in vascular endothelial cells. Even though PCBs are no longer produced, they are still detected in human blood and tissues and thus considered a risk for vascular dysfunction. We hypothesized that EGCG can protect endothelial cells against PCB-induced cell damage via its antioxidant and anti-inflammatory properties. To test this hypothesis, primary vascular endothelial cells were pretreated with EGCG, followed by exposure to the coplanar PCB 126. Exposure to PCB 126 significantly increased cytochrome P450 1A1 (Cyp1A1) mRNA and protein expression and superoxide production, events which were significantly attenuated following pretreatment with EGCG. Similarly, EGCG also reduced DNA binding of NF-κB and downstream expression of inflammatory markers such as monocyte chemotactic protein-1 (MCP-1) and vascular cell adhesion protein-1 (VCAM-1) after PCB exposure. Furthermore, EGCG decreased endogenous or base-line levels of Cyp1A1, MCP-1 and VCAM-1 in endothelial cells. Most of all, treatment of EGCG upregulated expression of NF-E2-related factor 2 (Nrf2)-controlled antioxidant genes, including glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1), in a dose-dependent manner. In contrast, silencing of Nrf2 increased Cyp1A1, MCP-1 and VCAM-1 and decreased GST and NQO1 expression, respectively. These data suggest that EGCG can inhibit AhR regulated genes and induce Nrf2-regulated antioxidant enzymes, thus providing protection against PCB-induced inflammatory responses in endothelial cells. -- Highlights: ► PCBs cause endothelial inflammation and subsequent atherosclerosis. ► Nutrition can modulate toxicity by environmental pollutants. ► We

  9. Role of p53–fibrinolytic system cross-talk in the regulation of quartz-induced lung injury

    SciTech Connect (OSTI)

    Bhandary, Yashodhar P.; Shetty, Shwetha K.; Marudamuthu, Amarnath S.; Fu, Jian; Pinson, Barbara M.; Levin, Jeffrey; Shetty, Sreerama

    2015-03-01

    Silica is the major component of airborne dust generated by wind, manufacturing and/or demolition. Chronic occupational inhalation of silica dust containing crystalline quartz is by far the predominant form of silicosis in humans. Silicosis is a progressive lung disease that typically arises after a very long latency and is a major occupational concern with no known effective treatment. The mechanism of silicosis is not clearly understood. However, silicosis is associated with increased cell death, expression of redox enzymes and pro-fibrotic cytokines and chemokines. Since alveolar epithelial cell (AEC) death and disruption of alveolar fibrinolysis is often associated with both acute and chronic lung injuries, we explored whether p53-mediated changes in the urokinase-type plasminogen activator (uPA) system contributes to silica-induced lung injury. We further sought to determine whether caveolin-1 scaffolding domain peptide (CSP), which inhibits p53 expression, mitigates lung injury associated with exposure to silica. Lung tissues and AECs isolated from wild-type (WT) mice exposed to silica exhibit increased apoptosis, p53 and PAI-1, and suppression of uPA expression. Treatment of WT mice with CSP inhibits PAI-1, restores uPA expression and prevents AEC apoptosis by suppressing p53, which is otherwise induced in mice exposed to silica. The process involves CSP-mediated inhibition of serine-15 phosphorylation of p53 by inhibition of protein phosphatase 2A-C (PP2A-C) interaction with silica-induced caveolin-1 in AECs. These observations suggest that changes in the p53–uPA fibrinolytic system cross-talk contribute to lung injury caused by inhalation of silica dust containing crystalline quartz and is protected by CSP by targeting this pathway. - Highlights: • Chronic exposure to quartz dusts is a major cause of lung injury and silicosis. • The survival of patients with silicosis is bleak due to lack of effective treatments. • This study defines a new role of

  10. Radiation-Induced Upregulation of Gene Expression From Adenoviral Vectors Mediated by DNA Damage Repair and Regulation

    SciTech Connect (OSTI)

    Nokisalmi, Petri; Rajecki, Maria; Pesonen, Sari; Escutenaire, Sophie; Soliymani, Rabah; Tenhunen, Mikko; Ahtiainen, Laura; Hemminki, Akseli

    2012-05-01

    Purpose: In the present study, we evaluated the combination of replication-deficient adenoviruses and radiotherapy in vitro. The purpose of the present study was to analyze the mechanism of radiation-mediated upregulation of adenoviral transgene expression. Methods and Materials: Adenoviral transgene expression (luciferase or green fluorescent protein) was studied with and without radiation in three cell lines: breast cancer M4A4-LM3, prostate cancer PC-3MM2, and lung cancer LNM35/enhanced green fluorescent protein. The effect of the radiation dose, modification of the viral capsid, and five different transgene promoters were studied. The cellular responses were studied using mass spectrometry and immunofluorescence analysis. Double strand break repair was modulated by inhibitors of heat shock protein 90, topoisomerase-I, and DNA protein kinase, and transgene expression was measured. Results: We found that a wide range of radiation doses increased adenoviral transgene expression regardless of the cell line, transgene, promoter, or viral capsid modification. Treatment with adenovirus, radiation, and double strand break repair inhibitors resulted in persistence of double strand breaks and subsequent increases in adenovirus transgene expression. Conclusions: Radiation-induced enhancement of adenoviral transgene expression is linked to DNA damage recognition and repair. Radiation induces a global cellular response that results in increased production of RNA and proteins, including adenoviral transgene products. This study provides a mechanistic rationale for combining radiation with adenoviral gene delivery.

  11. Climate Zones

    Broader source: Energy.gov [DOE]

    Building America determines building practices based on climate zones to achieve the most energy savings in a home. This page offers some general guidelines on the definitions of the various...

  12. Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear translocation in bone metastasis from breast carcinoma

    SciTech Connect (OSTI)

    Maroni, Paola; Matteucci, Emanuela; Drago, Lorenzo; Banfi, Giuseppe; Bendinelli, Paola; Desiderio, Maria Alfonsina

    2015-01-15

    The present study deals with the molecular mechanisms involved in the regulation of E-cadherin expression under hypoxia, because the adjustment of the amount of E-cadherin due to physical stimuli of the microenvironment might influence the colonization of metastasis to skeleton. We analyzed the effect of 1% oxygen tension, that is similar to that encountered in the bone marrow by metastatic cells spreading from breast carcinoma. The purpose was to evaluate the hypoxia-orchestrated control of E-cadherin transactivation via hypoxia inducible factor-1 (HIF-1) and peroxisome proliferator activated receptor-γ (PPARγ), and the involvement of Hippo pathway members, as regulators of transcription factors. To give a translational significance to the study, we took into consideration human pair-matched ductal breast carcinoma and bone metastasis: E-cadherin and Wwox were expressed in bone metastasis but not in breast carcinoma, while HIF-1α and TAZ seemed localized principally in nuclei of metastasis and were found in all cell compartments of breast carcinoma. A close examination of the regulatory mechanisms underlying E-cadherin expression in bone metastasis was done in 1833 clone derived from MDA-MB231 cells. Hypoxia induced E-cadherin only in 1833 clone, but not in parental cells, through HIF-1 and PPARγ activities, while Wwox decreased. Since Wwox was highly expressed in bone metastasis, the effect of ectopic Wwox was evaluated, and we showed E-cadherin transactivation and enhanced invasiveness in WWOX transfected 1833 cells. Also, hypoxia was additive with ectopic Wwox remarkably enhancing HIF-1α nuclear shuttle and accumulation due to the lengthening of the half-life of HIF-1α protein; under this experimental condition HIF-1α appeared as a slower migrated band compared with control, in agreement with the phosphorylation state. The in vitro data strongly supported the almost exclusive presence of HIF-1α in nuclei of human-bone metastasis. Thus, we identified

  13. Activation of PPAR{delta} up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic {beta}-cells

    SciTech Connect (OSTI)

    Wan, Jun; Jiang, Li; Lue, Qingguo; Ke, Linqiu; Li, Xiaoyu; Tong, Nanwei

    2010-01-15

    Recent evidence indicates that decreased oxidative capacity, lipotoxicity, and mitochondrial aberrations contribute to the development of insulin resistance and type 2 diabetes. The goal of this study was to investigate the effects of peroxisome proliferator-activated receptor {delta} (PPAR{delta}) activation on lipid oxidation, mitochondrial function, and insulin secretion in pancreatic {beta}-cells. After HIT-T15 cells (a {beta}-cell line) were exposed to high concentrations of palmitate and GW501516 (GW; a selective agonist of PPAR{delta}), we found that administration of GW increased the expression of PPAR{delta} mRNA. GW-induced activation of PPAR{delta} up-regulated carnitine palmitoyltransferase 1 (CPT1), long-chain acyl-CoA dehydrogenase (LCAD), pyruvate dehydrogenase kinase 4 (PDK4), and uncoupling protein 2 (UCP2); alleviated mitochondrial swelling; attenuated apoptosis; and reduced basal insulin secretion induced by increased palmitate in HIT cells. These results suggest that activation of PPAR{delta} plays an important role in protecting pancreatic {beta}-cells against aberrations caused by lipotoxicity in metabolic syndrome and diabetes.

  14. THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death

    SciTech Connect (OSTI)

    Balakrishnan, Meenakshi P.; Cilenti, Lucia; Ambivero, Camilla; Goto, Yamafumi; Takata, Minoru; Turkson, James; Li, Xiaoman Shawn; Zervos, Antonis S.

    2011-01-07

    Research highlights: {yields} THAP5 is a DNA-binding protein and a transcriptional repressor. {yields} THAP5 is induced in melanoma cells upon exposure to UV or treatment with cisplatin. {yields} THAP5 induction correlates with the degree of apoptosis in melanoma cell population. {yields} THAP5 is a pro-apoptotic protein involved in melanoma cell death. -- Abstract: THAP5 was originally isolated as a specific interactor and substrate of the mitochondrial pro-apoptotic Omi/HtrA2 protease. It is a human zinc finger protein characterized by a restricted pattern of expression and the lack of orthologs in mouse and rat. The biological function of THAP5 is unknown but our previous studies suggest it could regulate G2/M transition in kidney cells and could be involved in human cardiomyocyte cell death associated with coronary artery disease (CAD). In this report, we expanded our studies on the properties and function of THAP5 in human melanoma cells. THAP5 was expressed in primary human melanocytes as well as in all melanoma cell lines that were tested. THAP5 protein level was significantly induced by UV irradiation or cisplatin treatment, conditions known to cause DNA damage. The induction of THAP5 correlated with a significant increase in apoptotic cell death. In addition, we show that THAP5 is a nuclear protein that could recognize and bind a specific DNA motif. THAP5 could also repress the transcription of a reporter gene in a heterologous system. Our work suggests that THAP5 is a DNA-binding protein and a transcriptional repressor. Furthermore, THAP5 has a pro-apoptotic function and it was induced in melanoma cells under conditions that promoted cell death.

  15. Climate Change Response

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Addressing the Impact of Climate Change on America's Water, Land, and Other Natural and Cultural Resources Energy and Climate Change Council DOI Climate Science Centers ...

  16. Special Lecture - Climate Prisms: Understanding Climate Change...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Special Lecture - Climate Prisms Special Lecture - Climate Prisms: Understanding Climate Change for All WHEN: Feb 17, 2015 5:30 PM - 7:00 PM WHERE: Bradbury Science Museum, 1350...

  17. Carbon Dioxide Effects Research and Assessment Program. Workshop on environmental and societal consequences of a possible CO/sub 2/-induced climate change

    SciTech Connect (OSTI)

    1980-10-01

    The Workshop was part of a process of elucidating areas of uncertainty where research is needed before meaningful forecasts and sound decisions can be made about the CO/sub 2/ issue. The conferees were divided into five panels dealing with the ocean and the cryosphere: the less managed biosphere; the managed biosphere (chiefly agricultural, forest, and grazing lands); the ways society and its institutions might respond to climate changes; and issues involving the economic and geopolitical consequences of CO/sub 2/ build-up. Also, 28 papers or discussion drafts dealing with a wide variety of topics were contributed to the conference.

  18. Climate SIGNATURES

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SIGNATURES Fingerprints of a Dynamic Planet A Science of Signatures Plan 2 Climate Signatures for National Security Century of Change Los Alamos National Laboratory's charge is to develop science and technology that will make the Nation safer and enhance our global standing. This breadth of mission scope requires careful planning and effective cooperation with partners and other governmental agencies. The document you are holding is one of the products of ongoing efforts that are designed to

  19. Future warming patterns linked to today’s climate variability

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dai, Aiguo

    2016-01-11

    The reliability of model projections of greenhouse gas (GHG)-induced future climate change is often assessed based on models’ ability to simulate the current climate, but there has been little evidence that connects the two. In fact, this practice has been questioned because the GHG-induced future climate change may involve additional physical processes that are not important for the current climate. Here I show that the spatial patterns of the GHG-induced future warming in the 21st century is highly correlated with the patterns of the year-to-year variations of surface air temperature for today’s climate, with areas of larger variations during 1950–1979more » having more GHG-induced warming in the 21st century in all climate models. Such a relationship also exists in other climate fields such as atmospheric water vapor, and it is evident in observed temperatures from 1950–2010. The results suggest that many physical processes may work similarly in producing the year-to-year climate variations in the current climate and the GHG-induced long-term changes in the 21st century in models and in the real world. Furthermore, they support the notion that models that simulate present-day climate variability better are likely to make more reliable predictions of future climate change.« less

  20. Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells

    SciTech Connect (OSTI)

    Gorgani-Firuzjaee, Sattar; Adeli, Khosrow; Meshkani, Reza

    2015-08-21

    The serine–threonine kinase Akt regulates proliferation and survival by phosphorylating a network of protein substrates; however, the role of a negative regulator of the Akt pathway, the SH2-domain-containing inositol 5-phosphatase (SHIP2) in apoptosis of the hepatocytes, remains unknown. In the present study, we studied the molecular mechanisms linking SHIP2 expression to apoptosis using overexpression or suppression of SHIP2 gene in HepG2 cells exposed to palmitate (0.5 mM). Overexpression of the dominant negative mutant SHIP2 (SHIP2-DN) significantly reduced palmitate-induced apoptosis in HepG2 cells, as these cells had increased cell viability, decreased apoptotic cell death and reduced the activity of caspase-3, cytochrome c and poly (ADP-ribose) polymerase. Overexpression of the wild-type SHIP2 gene led to a massive apoptosis in HepG2 cells. The protection from palmitate-induced apoptosis by SHIP2 inhibition was accompanied by a decrease in the generation of reactive oxygen species (ROS). In addition, SHIP2 inhibition was accompanied by an increased Akt and FOXO-1 phosphorylation, whereas overexpression of the wild-type SHIP2 gene had the opposite effects. Taken together, these findings suggest that SHIP2 expression level is an important determinant of hepatic lipoapotosis and its inhibition can potentially be a target in treatment of hepatic lipoapoptosis in diabetic patients. - Highlights: • Lipoapoptosis is the major contributor to the development of NAFLD. • The PI3-K/Akt pathway regulates apoptosis in different cells. • The role of negative regulator of this pathway, SHIP2 in lipoapoptosis is unknown. • SHIP2 inhibition significantly reduces palmitate-induced apoptosis in HepG2 cells. • SHIP2 inhibition prevents palmitate induced-apoptosis by regulating Akt/FOXO1 pathway.

  1. Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression

    SciTech Connect (OSTI)

    Changchien, Jung-Jung; Chen, Ying-Jung; Huang, Chia-Hui; Cheng, Tian-Lu; Lin, Shinne-Ren; Chang, Long-Sen

    2015-04-01

    Although previous studies have revealed the anti-cancer activity of quinacrine, its effect on leukemia is not clearly resolved. We sought to explore the cytotoxic effect and mechanism of quinacrine action in human leukemia K562 cells. Quinacrine induced K562 cell apoptosis accompanied with ROS generation, mitochondrial depolarization, and down-regulation of BCL2L1 and BCL2. Upon exposure to quinacrine, ROS-mediated p38 MAPK activation and ERK inactivation were observed in K562 cells. Quinacrine-induced cell death and mitochondrial depolarization were suppressed by the p38MAPK inhibitor SB202190 and constitutively active MEK1 over-expression. Activation of p38 MAPK was shown to promote BCL2 degradation. Further, ERK inactivation suppressed c-Jun-mediated transcriptional expression of BCL2L1. Over-expression of BCL2L1 and BCL2 attenuated quinacrine-evoked mitochondrial depolarization and rescued the viability of quinacrine-treated cells. Taken together, our data indicate that quinacrine-induced K562 cell apoptosis is mediated through mitochondrial alterations triggered by p38 MAPK-mediated BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. - Highlights: • Quinacrine induces K562 cell apoptosis via down-regulation of BCL2 and BCL2L1. • Quinacrine induces p38 MAPK activation and ERK inactivation in K562 cells. • Quinacrine elicits p38 MAPK-mediated BCL2 down-regulation. • Quinacrine suppresses ERK/c-Jun-mediated BCL2L1 expression.

  2. Response of a tundra ecosystem to elevated atmospheric carbon dioxide and CO{sub 2}-induced climate change. Annual technical report

    SciTech Connect (OSTI)

    Oechel, W.C.

    1992-04-01

    Northern ecosystems contain up to 455 Gt of C in the soil active layer and upper permafrost. The soil carbon in these layers is equivalent to approximately 60% of the carbon currently in the atmosphere as CO{sub 2}. Much of this carbon is stored in the soil as dead organic matter. Its fate is subject to the net effects of global change on the plant and soil systems of northern ecosystems. The arctic alone contains about 60 Gt C, 90% of which is present in the soil active layer and upper permafrost. The arctic is assumed to have been a sink for CO{sub 2} during the historic and recent geologic past. The arctic has the potential to be a very large, long-term source or sink of CO{sub 2} with respect to the atmosphere. In situ experimental manipulations of atmospheric CO{sub 2}, indicated that there is little effect of elevated atmospheric CO{sub 2} on leaf level photosynthesis or whole-ecosystem CO{sub 2} flux over the course of weeks to years, respectively. However, there may be longer- term ecosystem responses to elevated CO{sub 2} that could ultimately affect ecosystem CO{sub 2} balance. In addition to atmospheric CO{sub 2}, climate may affect net ecosystem carbon balance. Recent results indicate that the arctic has become a source of CO{sub 2} to the atmosphere. This change coincides with recent climatic variation in the arctic, and suggests a positive feedback of arctic ecosystems on atmospheric CO{sub 2} and global change. The research proposed in this application has four principal aspects: (A) Long-term response of arctic plants and ecosystems to elevated atmospheric CO{sub 2}; (B) Circumpolar patterns of net ecosystem CO{sub 2} flux; (C) In situ controls by temperature and moisture on net ecosystem CO{sub 2} flux; (D) Scaling of CO{sub 2} flux from plot, to landscape, to regional scales (In conjunction with research proposed for NSF support).

  3. Tribal Climate Change Webinars: BIA's Climate Change Competitive...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Tribal Climate Change Webinars: BIA's Climate Change Competitive Award Process Overview Tribal Climate Change Webinars: BIA's Climate Change Competitive Award Process Overview...

  4. MCA4Climate - Guidance for scientifically sound climate change...

    Open Energy Info (EERE)

    MCA4Climate - Guidance for scientifically sound climate change planning Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Multicriteria Analysis for Climate (MCA4climate)...

  5. Detecting the climatic effects of increasing carbon dioxide

    SciTech Connect (OSTI)

    MacCracken, M C; Luther, F M

    1985-12-01

    This report documents what is known about detecting the CO2-induced changes in climate, and describes the uncertainties and unknowns associated with this monitoring and analysis effort. The various approaches for detecting CO2-induced climate changes are discussed first, followed by a review of applications of these strategies to the various climatic variables that are expected to be changing. Recommendations are presented for research and analysis activities. Separate abstracts have been prepared for the individual papers. (ACR)

  6. Climate Leadership Conference

    Broader source: Energy.gov [DOE]

    The annual Climate Leadership Conference convenes a global audience of climate, energy, and sustainability professionals to address climate change through policy, innovation, and business solutions. Now in its fifth year, the 2016 event will host the first U.S. climate conference post-Paris to further accelerate climate solutions and a low-carbon economy.

  7. Climate Data Operators (CDO)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Data Operators (CDO) Climate Data Operators (CDO) Description and Overview CDO is a large tool set for working on climate data. NetCDF 34, GRIB including SZIP compression, ...

  8. Assessing Climate Uncertainty

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Uncertainty The uncertainty in climate change and in its impacts is of great concern to the international community. While the ever-growing body of scientific evidence substantiates present climate change, the driving concern about this issue lies in the consequences it poses to humanity. Policy makers will most likely need to make decisions about climate policy before climate scientists have quantified all relevant uncertainties about the impacts of climate change. Sandia scientists

  9. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 ARM Climate Research Facility Quarterly Ingest Status Report A Koontz C Sivaraman ... DOESC-ARM-14-003 ARM Climate Research Facility Quarterly Ingest Report First Quarter: ...

  10. Global Climate & Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SunShot Grand Challenge: Regional Test Centers Global Climate & Energy HomeTag:Global Climate & Energy Electricity use by water service sector and county. Shown are electricity ...

  11. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 ARM Climate Research Facility Quarterly Ingest Status Report A Koontz C Sivaraman ... DOESC-ARM-14-028 ARM Climate Research Facility Quarterly Ingest Report Fourth Quarter: ...

  12. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 ARM Climate Research Facility Quarterly Ingest Status Report A Koontz C Sivaraman ... DOESC-ARM-15-003 ARM Climate Research Facility Quarterly Ingest Report First Quarter: ...

  13. Climate change cripples forests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate change cripples forests Climate change cripples forests A team of scientists concluded that in the warmer and drier Southwest of the near future, widespread tree mortality ...

  14. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOESC-ARM-15-019 ARM Climate Research Facility Quarterly Value-Added Product Report ... implemented by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. ...

  15. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOESC-ARM-15-020 ARM Climate Research Facility Quarterly Ingest Report Second Quarter: ... maintained by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. ...

  16. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ARM Climate Research Facility Quarterly Ingest Status Report A Koontz C Sivaraman April ... DOESC-ARM-14-014 ARM Climate Research Facility Quarterly Ingest Report Second Quarter: ...

  17. Global Climate & Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Team Attends World Water Week in Stockholm Climate, Energy, Global Climate & Energy, Modeling, Modeling & Analysis, News, News & Events, Water Security Sandia Team Attends World ...

  18. Climate change cripples forests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    during years with abnormally wet winters While we cannot observe future climate, Williams said, we can consider projections of future climate trends produced by a collection of...

  19. Climate change cripples forests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Change Cripples Forests Climate change cripples forests A team of scientists concluded that in the warmer and drier Southwest of the near future, widespread tree mortality...

  20. Climate selection and development of climate indicators

    SciTech Connect (OSTI)

    Bowen, W.M.; Moreno, S.; Olsen, A.R.

    1982-09-01

    A climate analysis procedure for selecting climate locations which would represent the variation in climate conditions throughout the United States is documented. Separate energy analysis projects for three building categories were to use the results of the climate location project. The categories are: commercial buildings (including multifamily residences), single family residences, and mobile homes. The overall objectives, approach, and method used for all three categories are presented, then the specific application of the general method to each building category is discussed. Climate selection results, conclusions, recommendations, and limits for each building category are presented within the description of the application of the method for that category. (LEW)

  1. Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin

    SciTech Connect (OSTI)

    Pratheeshkumar, Poyil; Son, Young-Ok; Wang, Xin; Divya, Sasidharan Padmaja; Joseph, Binoy; Hitron, John Andrew; Wang, Lei; Kim, Donghern; Yin, Yuanqin; Roy, Ram Vinod; Lu, Jian; Zhang, Zhuo; Wang, Yitao; and others

    2014-10-01

    Skin cancer is one of the most commonly diagnosed cancers in the United States. Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is present in various vegetables and fruits especially in edible berries, and displays potent antioxidant and anticarcinogenic properties. In this study, we have assessed the in vivo effects of C3G on UVB irradiation induced chronic inflammatory responses in SKH-1 hairless mice, a well-established model for UVB-induced skin carcinogenesis. Here, we show that C3G inhibited UVB-induced skin damage and inflammation in SKH-1 hairless mice. Our results indicate that C3G inhibited glutathione depletion, lipid peroxidation and myeloperoxidation in mouse skin by chronic UVB exposure. C3G significantly decreased the production of UVB-induced pro-inflammatory cytokines, such as IL-6 and TNF-α, associated with cutaneous inflammation. Likewise, UVB-induced inflammatory responses were diminished by C3G as observed by a remarkable reduction in the levels of phosphorylated MAP kinases, Erk1/2, p38, JNK1/2 and MKK4. Furthermore, C3G also decreased UVB-induced cyclooxygenase-2 (COX-2), PGE{sub 2} and iNOS levels, which are well-known key mediators of inflammation and cancer. Treatment with C3G inhibited UVB-induced nuclear translocation of NF-κB and degradation of IκBα in mice skin. Immunofluorescence assay revealed that topical application of C3G inhibited the expression of 8-hydroxy-2′-deoxyguanosine, proliferating cell nuclear antigen, and cyclin D1 in chronic UVB exposed mouse skin. Collectively, these data indicates that C3G can provide substantial protection against the adverse effects of UVB radiation by modulating UVB-induced MAP kinase and NF-κB signaling pathways. - Highlights: • C3G inhibited UVB-induced oxidative damage and inflammation. • C3G inhibited UVB-induced COX-2, iNOS and PGE{sub 2} production. • C3G

  2. Climate Leadership Conference

    Broader source: Energy.gov [DOE]

    Hosted and organized by the Association of Climate Change Officers (ACCO), Center for Climate and Energy Solutions (C2ES), and the Climate Registry, the three-day conference will showcase how new business opportunities, current policies, technologies, climate solutions and energy transformation will drive our low-carbon future.

  3. Global Climate & Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CRF_climatechange Permalink Gallery Understanding Hazardous Combustion Byproducts Reduces Factors Impacting Climate Change CRF, Global Climate & Energy, News, News & Events, Transportation Energy Understanding Hazardous Combustion Byproducts Reduces Factors Impacting Climate Change By Micheal Padilla Researchers at Sandia's Combustion Research Facility are developing the understanding necessary to build cleaner combustion technologies that will in turn reduce climate impact. Their work

  4. EPA Climate Leadership Conference

    Broader source: Energy.gov [DOE]

    The U.S. Environmental Protection Agency (EPA), in collaboration with the Association of Climate Change Officers (ACCO), Center for Climate and Energy Solutions (C2ES), and the Climate Registry, is hosting the Climate Leadership Conference in Washington, D.C., on Feb. 23-25, 2015.

  5. Acquisition Regulation

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Career Development, Contracting Authority and Responsibilities Acquisition Regulation ... file, except for any documents required by regulation to be maintained in paper copy. ...

  6. NREL: Climate Neutral Research Campuses - Implementing the Climate...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Implementing the Climate Action Plan When implementing climate action plans on research campuses, two important and related questions must be answered. How do we pay for climate ...

  7. Formulating Climate Change Scenarios to Inform Climate - Resilient...

    Open Energy Info (EERE)

    Formulating Climate Change Scenarios to Inform Climate - Resilient Development Strategies Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Formulating Climate Change...

  8. TROPICAL METEOROLOGY & Climate: Hadley Circulation

    SciTech Connect (OSTI)

    Lu, Jian; Vecchi, Gabriel A.

    2015-01-30

    The Hadley circulation, a prominent circulation feature characterized by rising air near the Equator and sinking air in the subtropics, defines the position of dry subtropical areas and is a fundamental regulator of the earth’s energy and momentum budgets. The character of the Hadley circulation, and its related precipitation regimes, exhibits variation and change in response to both climate variability and radiative forcing changes. The strength and position of the Hadley circulation change from year to year paced by El Niño and La Niña events. Over the last few decades of the twentieth century, the Hadley cell has expanded poleward in both hemispheres, with changes in atmospheric composition (including stratospheric ozone depletion and greenhouse gas increases) thought to have contributed to its expansion. This article introduces the basic phenomenology and driving mechanism of the Hadley circulation and discusses its variations under both natural and anthropogenic climate forcings.

  9. Climatic Solar | Open Energy Information

    Open Energy Info (EERE)

    Climatic Solar Jump to: navigation, search Logo: Climatic Solar Name: Climatic Solar Address: 650 2nd Lane Place: Vero Beach, Florida Zip: 32962 Sector: Solar Product: solar energy...

  10. Eos Climate | Open Energy Information

    Open Energy Info (EERE)

    Eos Climate Place: South San Francisco, California Zip: 94080 Product: California-based firm focused on developing climate change mitigation strategies. References: Eos Climate1...

  11. Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Information Center Regulations Regulations Personnel Security Regulations Click Here FOIA Regulations Click Here Privacy Act Regulations Click Here Whistleblower Protection ...

  12. VOLTAGE REGULATOR

    DOE Patents [OSTI]

    Von Eschen, R.L.; Scheele, P.F.

    1962-04-24

    A transistorized voltage regulator which provides very close voitage regulation up to about 180 deg F is described. A diode in the positive line provides a constant voltage drop from the input to a regulating transistor emitter. An amplifier is coupled to the positive line through a resistor and is connected between a difference circuit and the regulating transistor base which is negative due to the difference in voltage drop across thc diode and the resistor so that a change in the regulator output causes the amplifier to increase or decrease the base voltage and current and incrcase or decrease the transistor impedance to return the regulator output to normal. (AEC)

  13. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9 ARM Climate Research Facility Quarterly Value-Added Product Report C Sivaraman April ... DOESC-ARM-14-009 ARM Climate Research Facility Quarterly Value-Added Product Report First ...

  14. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 ARM Climate Research Facility Quarterly Value-Added Product Report C Sivaraman January ... DOESC-ARM-14-002 ARM Climate Research Facility Quarterly Value-Added Product Report First ...

  15. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7 ARM Climate Research Facility Quarterly Value-Added Product Report C Sivaraman October ... DOESC-ARM-14-027 ARM Climate Research Facility Quarterly Value-Added Product Report ...

  16. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 ARM Climate Research Facility Quarterly Value-Added Product Report Chitra Sivaraman ... DOESC-ARM-11-023 ARM Climate Research Facility Quarterly Value-Added Product Report ...

  17. ARM - Climate Change

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Climate Change A Student's Guide to Global Climate Change ...

  18. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 ARM Climate Research Facility Quarterly Ingest Status Report A Koontz C Sivaraman July ... DOESC-ARM-14-023 ARM Climate Research Facility Quarterly Ingest Report Third Quarter: ...

  19. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 ARM Climate Research Facility Quarterly Value-Added Product Report C Sivaraman July 2015 ... DOESC-ARM-15-038 ARM Climate Research Facility Quarterly Value-Added Product Report Third ...

  20. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 ARM Climate Research Facility Quarterly Value-Added Product Report C Sivaraman January ... DOESC-ARM-15-002 ARM Climate Research Facility Quarterly Value-Added Product Report First ...

  1. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 ARM Climate Research Facility Quarterly Value-Added Product Report C Sivaraman July 2014 ... DOESC-ARM-14-020 ARM Climate Research Facility Quarterly Value-Added Product Report Third ...

  2. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 ARM Climate Research Facility Quarterly Value-Added Product Report C Sivaraman February ... DOESC-ARM-12-002 ARM Climate Research Facility Quarterly Value-Added Product Report First ...

  3. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 ARM Climate Research Facility Quarterly Value-Added Product Report Chitra Sivaraman ... DOESC-ARM-11-021 ARM Climate Research Facility Quarterly Value-Added Product Report Third ...

  4. Climate Leadership Conference

    Broader source: Energy.gov [DOE]

    The Climate Leadership Conference is your annual exchange for addressing global climate change through policy, innovation, and business solutions. Forward-thinking lead­ers from busi­ness, gov­ern...

  5. Indigenous Climate Justice Symposium

    Broader source: Energy.gov [DOE]

    The Indigenous Climate Justice Symposium brings together Native speakers who are working to keep fossil fuels in the ground, by stopping coals terminals, oil trains and fracking, and protecting treaty resources from the threat of climate change.

  6. Global Climate & Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sandia Participated in the 2013 Domenici Public Policy Conference Carbon Capture & Storage, Carbon Storage, Climate, Earth Sciences Research Center, Energy, Global Climate & Energy, Global Climate & Energy, News, News & Events, Systems Analysis, Systems Engineering, Water Security Sandia Participated in the 2013 Domenici Public Policy Conference Marianne Walck, Director of Sandia's Geoscience, Climate, and Consequence Effects Center, spoke on "Hydraulic Fracturing: The Role

  7. ACCO Climate Change Adaptation Workshop

    Broader source: Energy.gov [DOE]

    The Association of Climate Change Officers (ACCO) is hosting a two-day training workshop titled, "Climate Change Adaptation" to cover climate science, impacts from severe climate events, tools to screen and access vulnerabilities, and strategies to lead organizational change.

  8. {gamma}-aminobutyric acid{sub A} (GABA{sub A}) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of Methyl Tert-Butyl Ether (MTBE)-induced impairment of spatial memory

    SciTech Connect (OSTI)

    Zheng Gang; Zhang Wenbin; Zhang Yun; Chen Yaoming; Liu Mingchao; Yao Ting; Yang Yanxia; Zhao Fang; Li Jingxia; Huang Chuanshu; Luo Wenjing Chen Jingyuan

    2009-04-15

    Experimental and occupational exposure to Methyl Tert-Butyl Ether (MTBE) has been reported to induce neurotoxicological and neurobehavioral effects, such as headache, nausea, dizziness, and disorientation, etc. However, the molecular mechanisms involved in MTBE-induced neurotoxicity are still not well understood. In the present study, we investigated the effects of MTBE on spatial memory and the expression and function of GABA{sub A} receptor in the hippocampus. Our results demonstrated that intraventricular injection of MTBE impaired the performance of the rats in a Morris water maze task, and significantly increased the expression of GABA{sub A} receptor {alpha}1 subunit in the hippocampus. The phosphorylation of ERK1/2 decreased after the MTBE injection. Furthermore, the decreased ability of learning and the reduction of phosphorylated ERK1/2 level of the MTBE-treated rats was partly reversed by bicuculline injected 30 min before the training. These results suggested that MTBE exposure could result in impaired spatial memory. GABA{sub A} receptor may play an important role in the MTBE-induced impairment of learning and memory by regulating the phosphorylation of ERK in the hippocampus.

  9. Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function During Nanoparticle-Induced Oxidative Stress

    SciTech Connect (OSTI)

    Duan, Jicheng; Kodali, Vamsi K.; Gaffrey, Matthew J.; Guo, Jia; Chu, Rosalie K.; Camp, David G.; Smith, Richard D.; Thrall, Brian D.; Qian, Weijun

    2015-12-23

    Engineered nanoparticles (ENPs) are emerging functional materials increasingly utilized for commercial and medical applications. Due to the potential hazard effects of ENPs to human health, it is significant to assess and understand the underlying mechanisms of nanotoxicity. Herein, we investigate protein S-glutathionylation (SSG) as an underlying regulatory mechanism for ENP-induced oxidative stress in macrophages by applying a recently developed quantitative redox proteomics approach for site-specific measurements of SSG. Three high-volume production ENPs (SiO2, Fe3O4 and CoO) were selected as representative ENPs with low, moderate, and high reactive oxygen species (ROS) activity, respectively. Among these nanoparticles, we observe that CoO led to the most significant dose-dependent oxidative stress and increase of protein SSG modifications in macrophages. Our site-specific SSG changes highlighted a broad set of redox sensitive proteins and their specific Cys residues potentially implicated in stress response. Functional analysis revealed that the most significantly enriched functional categories for SSG-modified proteins were stress response, cellular structure change, and cell death or survival. Moreover, ENPs-induce oxidative stress levels (CoO > Fe3O4 > SiO2) were found to correlate well with the levels of impairment of macrophage phagocytic activity and the overall degrees of increases in SSG. RNA silencing knockdown experiment of glutaredoxin 1 (Grx1) also led to a decreased phagocytic activity in macrophages, which suggested a regulatory role of SSG in phagocytosis. Together, the results provided valuable insights of protein SSG as a potential regulatory mechanism in response to nanomaterial-induced oxidative stress and immunity dysfunction.

  10. Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function During Nanoparticle-Induced Oxidative Stress

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Duan, Jicheng; Kodali, Vamsi K.; Gaffrey, Matthew J.; Guo, Jia; Chu, Rosalie K.; Camp, David G.; Smith, Richard D.; Thrall, Brian D.; Qian, Wei-Jun

    2015-12-23

    Engineered nanoparticles (ENPs) are emerging functional materials increasingly utilized for commercial and medical applications. Due to the potential hazard effects of ENPs to human health, it is significant to assess and understand the underlying mechanisms of nanotoxicity. Here, we investigate protein S-glutathionylation (SSG) as an underlying regulatory mechanism for ENP-induced oxidative stress in macrophages by applying a recently developed quantitative redox proteomics approach for site-specific measurements of SSG. Three high-volume production ENPs (SiO2, Fe3O4 and CoO) were selected as representative ENPs with low, moderate, and high reactive oxygen species (ROS) activity, respectively. Among these nanoparticles, we observe that CoO ledmore » to the most significant dose-dependent oxidative stress and increase of protein SSG modifications in macrophages. Our site-specific SSG changes highlighted a broad set of redox sensitive proteins and their specific Cys residues potentially implicated in stress response. Functional analysis revealed that the most significantly enriched functional categories for SSG-modified proteins were stress response, cellular structure change, and cell death or survival. Moreover, ENPs-induce oxidative stress levels (CoO > Fe3O4 > SiO2) were found to correlate well with the levels of impairment of macrophage phagocytic activity and the overall degrees of increases in SSG. RNA silencing knockdown experiment of glutaredoxin 1 (Grx1) also led to a decreased phagocytic activity in macrophages, which suggested a regulatory role of SSG in phagocytosis. Together, the results provided valuable insights of protein SSG as a potential regulatory mechanism in response to nanomaterial-induced oxidative stress and immunity dysfunction.« less

  11. Reciprocal Regulation of Hypoxia-Inducible Factor 2α and GLI1 Expression Associated With the Radioresistance of Renal Cell Carcinoma

    SciTech Connect (OSTI)

    Zhou, Jiancheng; Wu, Kaijie; Gao, Dexuan; Zhu, Guodong; Wu, Dapeng; Wang, Xinyang; Chen, Yule; Du, Yuefeng; Song, Wenbin; Ma, Zhenkun; Authement, Craig; Saha, Debabrata; Hsieh, Jer-Tsong; He, Dalin

    2014-11-15

    Purpose: Renal cell carcinoma (RCC) is often considered a radioresistant tumor, but the molecular mechanism underlying its radioresistance is poorly understood. This study explored the roles of hypoxia-inducible factor 2α (HIF2α) and sonic hedgehog (SHH)-GLI1 signaling in mediating the radioresistance of RCC cells and to unveil the interaction between these 2 signaling pathways. Methods and Materials: The activities of SHH-GLI1 signaling pathway under normoxia and hypoxia in RCC cells were examined by real-time polymerase chain reaction, Western blot, and luciferase reporter assay. The expression of HIF2α and GLI1 in RCC patients was examined by immunohistochemistry, and their correlation was analyzed. Furthermore, RCC cells were treated with HIF2α-specific shRNA (sh-HIF2α), GLI1 inhibitor GANT61, or a combination to determine the effect of ionizing radiation (IR) on RCC cells based on clonogenic assay and double-strand break repair assay. Results: RCC cells exhibited elevated SHH-GLI1 activities under hypoxia, which was mediated by HIF2α. Hypoxia induced GLI1 activation through SMO-independent pathways that could be ablated by PI3K inhibitor or MEK inhibitor. Remarkably, the SHH-GLI1 pathway also upregulated HIF2α expression in normoxia. Apparently, there was a positive correlation between HIF2α and GLI1 expression in RCC patients. The combination of sh-HIF2α and GLI1 inhibitor significantly sensitized RCC cells to IR. Conclusions: Cross-talk between the HIF2α and SHH-GLI1 pathways was demonstrated in RCC. Cotargeting these 2 pathways, significantly sensitizing RCC cells to IR, provides a novel strategy for RCC treatment.

  12. Assessing climate impacts of planning policies-An estimation for the urban region of Leipzig (Germany)

    SciTech Connect (OSTI)

    Schwarz, Nina Bauer, Annette Haase, Dagmar

    2011-03-15

    Local climate regulation by urban green areas is an important urban ecosystem service, as it reduces the extent of the urban heat island and therefore enhances quality of life. Local and regional planning policies can control land use changes in an urban region, which in turn alter local climate regulation. Thus, this paper describes a method for estimating the impacts of current land uses as well as local and regional planning policies on local climate regulation, using evapotranspiration and land surface emissivity as indicators. This method can be used by practitioners to evaluate their policies. An application of this method is demonstrated for the case study Leipzig (Germany). Results for six selected planning policies in Leipzig indicate their distinct impacts on climate regulation and especially the role of their spatial extent. The proposed method was found to easily produce a qualitative assessment of impacts of planning policies on climate regulation.

  13. Climate Change Response

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Interior Climate Change Response "From the Everglades to the Great Lakes to Alaska and everywhere in between, climate change is a leading threat to natural and cultural resources across America, and tribal communities are often the hardest hit by severe weather events such as droughts, floods and wildfires" - Secretary of the Interior Sally Jewell "Impacts of climate change are increasingly evident for American Indian and Alaska Native communities and, in some cases, threaten

  14. Climate Data Operators (CDO)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Change: Effects on Our Energy Climate Change: Effects on Our Energy July 11, 2013 - 9:00am Addthis The Energy Sector's Vulnerabilities to Climatic Conditions x Impacts Due to... Increasing Temperatures Decreasing Water Availability Increasing Storms, Flooding, and Sea Level Rise See All Impacts Map locations are approximate. Find out more about this data here. Click and drag the map to read about each location. April Saylor April Saylor Former Digital Outreach Strategist, Office of

  15. Climate Change Webinar Series

    Broader source: Energy.gov [DOE]

    Experts will provide findings from the Quadrennial Energy Review (QER) and outline federal energy policy objectives, proposals, and actions as they relate to climate change and resilience for...

  16. Climate Time-Machine

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Time-Machine Climate Time-Machine 20th Century Reanalysis Project Explores Earth's Past and Future Climate January 25, 2011 Berkeley Lab Contact: Jon Bashor, jbashor@lbl.gov, +1 510 486 5849 Wiley-Blackwell Contact: Ben Norman, lifesciencenews@wiley.com,+44(0)1243 770 375 Science Contact: Jeffrey Whitaker, Jeffrey.S.Whitaker@noaa.gov, +1 303 497 6313 2011-01-25-20C-Climate.jpg A dust storm approaching Stratford, TX on April 18, 1935. The 20th Century Reanalysis Project will provide

  17. Climate Change Adaptation | Department of Energy

    Energy Savers [EERE]

    Climate Change Adaptation Climate Change Adaptation DOE is adapting to climate change by applying a risk-based resiliency approach to identify and minimize climate-related...

  18. NREL Climate Activities | Open Energy Information

    Open Energy Info (EERE)

    NREL Climate Activities (Redirected from Climate Activities at NREL) Jump to: navigation, search Logo: Climate Activities at NREL Name Climate Activities at NREL AgencyCompany...

  19. Regional Climate Change Webinar Presentation | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Climate Change Webinar Presentation Regional Climate Change Webinar Presentation Regional Climate Change Webinar presentation dated August 6, 2015. Regional Climate Change Webinar ...

  20. European Climate Foundation (ECF) | Open Energy Information

    Open Energy Info (EERE)

    European Climate Foundation (ECF) (Redirected from European Climate Foundation) Jump to: navigation, search Logo: European Climate Foundation (ECF) Name: European Climate...

  1. ClimateChangeLIVE Webcast: Join the Climate Conversation

    Broader source: Energy.gov [DOE]

    Join ClimateChangeLIVE's webcast, bringing together students and climate experts for a discussion about climate change and what students and classes around the country are doing to be part of the climate solution. Students will be able to interact with climate scientists and experts online through Facebook and Twitter. A GreenWorks! grant will be offered to help schools with climate action projects.

  2. Indigenous Climate Justice Symposium

    Broader source: Energy.gov [DOE]

    The Indigenous Climate Justice Symposium brings together Native speakers who are working to keep fossil fuels in the ground, by stopping coals terminals, oil trains and fracking, and protecting treaty resources from the threat of climate change. All events are free and open to Evergreen students and the public.

  3. NERSC Climate PIs Telecon!

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Applications at NERSC Climate Projects --- 2 --- 75 Climate Projects at NERSC (AY2015) * Awards a re p ublished a t: - h%ps://www.nersc.gov/users/accounts/awarded---projects/2015--- alloca<on---awards/ * Or y ou c an s earch i n N IM * 29 p rojects u se C ESM o r C ESM c omponents. 2 47 u sers * 16 p rojects u se W RF. 3 6 u sers. --- 3 --- Climate Projects at NERSC (AY2015)-1 Repo Project T itle PI OrganizaMon Codes mp9 Climate C hange S imula<ons w ith C ESM: M oderate a nd H igh

  4. Economic impact of climate

    SciTech Connect (OSTI)

    Eddy, A.

    1980-05-01

    This volume summarizes the first two of a series of six workshops to investigate the economic impact of climate. These two workshops dealt mainly with input-output and econometric models. Potential for introducing weather and climate variables was discussed. A listing of topics and authors follows: Economic Models and the Identification of Climatic Effects on Economic Processes, Stan Johnson; Economic Modeling, Jim Morgan; Econometric Modeling: State of the Arts for the US Agricultural Industry, Abner Womack; Regional Input-Output Models: Understanding Their Application, Charles Lamphear; Measuring Regional Economic Impact Associated With Unfavorable Conditions During Crop Production Periods: A concept Paper, Charles Lamphear; Possible Applications of Input-Output Models in Climatic Impact Analysis, William Cooter; and Aspects of Input-Output Analysis Pertinent to Climate-Economic Modeling: Three Short Notes, William Cooter. (PSB)

  5. Climate Advisers | Open Energy Information

    Open Energy Info (EERE)

    and climate-related forest conservation. Climate Advisers is known for its vision, policy expertise, political acumen, and access to senior policymakers in the United States...

  6. IP_Climate_Poster 121312

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Title: Northern New Mexico Climate, Water Year 2012 at Los Alamos National Laboratory, ... The water year is a more hydrologically sound measure of climate and hydrological activity ...

  7. Changing Climate Doug Sisterson Environmental ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Change Minds about our Changing Climate Doug Sisterson Environmental Science Division, ... We are regularly confronted with arguments that deny climate change is happening or is a ...

  8. OPEN HOUSE - Climate Prisms: Arctic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    An interactive exploration of Arctic climate science through prisms of the visual arts, literary arts, info-vis, scientific presentations and more. Climate Prisms: Arctic is...

  9. Climate Energy | Open Energy Information

    Open Energy Info (EERE)

    Climate Energy Jump to: navigation, search Name: Climate Energy Place: Witham, England, United Kingdom Zip: CM8 3UN Sector: Efficiency Product: Essex, UK, based provider of advice...

  10. Refining climate models

    ScienceCinema (OSTI)

    Warren, Jeff; Iversen, Colleen; Brooks, Jonathan; Ricciuto, Daniel

    2014-06-26

    Using dogwood trees, Oak Ridge National Laboratory researchers are gaining a better understanding of the role photosynthesis and respiration play in the atmospheric carbon dioxide cycle. Their findings will aid computer modelers in improving the accuracy of climate simulations.

  11. Refining climate models

    SciTech Connect (OSTI)

    Warren, Jeff; Iversen, Colleen; Brooks, Jonathan; Ricciuto, Daniel

    2012-10-31

    Using dogwood trees, Oak Ridge National Laboratory researchers are gaining a better understanding of the role photosynthesis and respiration play in the atmospheric carbon dioxide cycle. Their findings will aid computer modelers in improving the accuracy of climate simulations.

  12. Climate Change Adaptation Planning

    Broader source: Energy.gov [DOE]

    This course provides an introduction to planning for climate change impacts, with examples of tribes that have been going through the adaptation planning process. The course is intended for tribal...

  13. Arctic Climate Measurements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Measurements - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear

  14. Global Climate & Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sandians Published in American Chemical Society's Environmental Science & Technology Analysis, Climate, Energy, Global Climate & Energy, Modeling, Modeling & Analysis, News, News & Events, Systems Analysis, Water Security Sandians Published in American Chemical Society's Environmental Science & Technology Electricity use by water service sector and county. Shown are electricity use by (a) large-scale conveyance, (b) groundwater irrigation pumping, (c) surface water irrigation

  15. Climate change cripples forests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate change cripples forests Climate change cripples forests A team of scientists concluded that in the warmer and drier Southwest of the near future, widespread tree mortality will cause forest and species distributions to change substantially. October 1, 2012 A dead pinon at the edge of the Grand Canyon, harbinger of the future for trees in the Southwest United States. Photo courtesy A. Park Williams. A dead pinon at the edge of the Grand Canyon, harbinger of the future for trees in the

  16. Climate Action Champion: Technical

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    energy.gov/betterbuildings Climate Action Champion: Technical Assistance to the City of Seattle Planning for Seattle's new Building Energy Code Overview The City of Seattle, identified as a Climate Action Champion (CAC) by the Department of Energy (DOE), is revising its 2012 Energy Code, already one of the most progressive in the country. Seattle has made a pledge to be carbon neutral by 2050. Seattle received technical assistance from the Pacific Northwest National Laboratory in order to

  17. Climate change cripples forests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Change Cripples Forests Climate change cripples forests A team of scientists concluded that in the warmer and drier Southwest of the near future, widespread tree mortality will cause forest and species distributions to change substantially. October 1, 2012 A dead pinon at the edge of the Grand Canyon, harbinger of the future for trees in the Southwest United States. Photo courtesy A. Park Williams. A dead pinon at the edge of the Grand Canyon, harbinger of the future for trees in the

  18. Climate change cripples forests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Change Cripples Forests Climate change cripples forests A team of scientists concluded that in the warmer and drier Southwest of the near future, widespread tree mortality will cause forest and species distributions to change substantially. October 1, 2012 A dead pinon at the edge of the Grand Canyon, harbinger of the future for trees in the Southwest United States. Photo courtesy A. Park Williams. A dead pinon at the edge of the Grand Canyon, harbinger of the future for trees in the

  19. Climate Action Champions: Southeast Florida Regional Climate Change

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Compact, FL | Department of Energy Southeast Florida Regional Climate Change Compact, FL Climate Action Champions: Southeast Florida Regional Climate Change Compact, FL The Southeast Florida Regional Climate Change Compact was executed by Broward, Miami-Dade, Monroe, and Palm Beach Counties in January 2010 to coordinate mitigation and adaptation efforts across county lines. The Compact represents a new form of regional climate governance designed to allow local governments to set the agenda

  20. Uptake of donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light by recipient dendritic cells induces CD4{sup +}CD25{sup +}Foxp3{sup +} regulatory T cells and down-regulates cardiac allograft rejection

    SciTech Connect (OSTI)

    Zheng, De-Hua; Dou, Li-Ping; Wei, Yu-Xiang; Du, Guo-Sheng; Zou, Yi-Ping; Song, Ji-Yong; Zhu, Zhi-Dong; Cai, Ming; Qian, Ye-Yong; Shi, Bing-Yi

    2010-05-14

    Extracorporeal photopheresis (ECP) is an effective immunomodulatory therapy and has been demonstrated to be beneficial for graft-vs-host disease and solid-organ allograft rejection. ECP involves reinfusion of a patient's autologous peripheral blood leukocytes treated ex vivo with 8-methoxypsoralen and UVA light radiation (PUVA). Previous studies focused only on ECP treatment of recipient immune cells. Our study is the first to extend the target of ECP treatment to donor immune cells. The results of in vitro co-culture experiments demonstrate uptake of donor PUVA-treated splenic lymphocytes (PUVA-SPs) by recipient immature dendritic cells (DCs). Phagocytosis of donor PUVA-SPs does not stimulate phenotype maturation of recipient DCs. In the same co-culture system, donor PUVA-SPs enhanced production of interleukin-10 and interferon-{gamma} by recipient DCs and impaired the subsequent capability of recipient DCs to stimulate recipient naive T cells. Phagocytosis of donor PUVA-SP (PUVA-SP DCs) by recipient DCs shifted T-cell responses in favor of T helper 2 cells. Infusion of PUVA-SP DCs inhibited cardiac allograft rejection in an antigen-specific manner and induced CD4{sup +}CD25{sup high}Foxp3{sup +} regulatory T cells. In conclusion, PUVA-SP DCs simultaneously deliver the donor antigen and the regulatory signal to the transplant recipient, and thus can be used to develop a novel DC vaccine for negative immune regulation and immune tolerance induction.

  1. Variation in Estimated Ozone-Related Health Impacts of Climate Change due to Modeling Choices and Assumptions

    SciTech Connect (OSTI)

    Post, Ellen S.; Grambsch, A.; Weaver, C. P.; Morefield, Philip; Huang, Jin; Leung, Lai-Yung R.; Nolte, Christopher G.; Adams, P. J.; Liang, Xin-Zhong; Zhu, J.; Mahoney, Hardee

    2012-11-01

    Future climate change may cause air quality degradation via climate-induced changes in meteorology, atmospheric chemistry, and emissions into the air. Few studies have explicitly modeled the potential relationships between climate change, air quality, and human health, and fewer still have investigated the sensitivity of estimates to the underlying modeling choices.

  2. World agriculture and climate change: Current modeling issues

    SciTech Connect (OSTI)

    Darwin, R.

    1996-12-31

    Recent studies suggest that although global increases in temperature and changes in precipitation patterns during the next century will affect world agriculture, farmer adaptations are likely to prevent climate change from jeopardizing world food production. The costs and benefits of global climate change, however, are not equally distributed around the world. Agricultural production may increase in high latitude and alpine areas, but decrease in tropical and some other areas. Also, land use changes that accompany climate-induced shifts in cropland and permanent pasture are likely to raise additional social and environmental issues. Despite these advances, some important aspects of climate change have not been adequately simulated in global models. These include the effects that climate-induced changes in water resources are likely to have on agricultural production, the well-documented beneficial effects of higher concentrations of atmospheric carbon dioxide on plant growth and water use, and the cooling effects of tropospheric emissions of sulfur dioxide. In addition, past research generally relied on equilibrium climates based on a doubling of atmospheric carbon dioxide. Now, however, results from transient climate change experiments are available.

  3. Geoengineering the Earth's Climate

    ScienceCinema (OSTI)

    Google Tech Talks

    2009-09-01

    Emergency preparedness is generally considered to be a good thing, yet there is no plan regarding what we might do should we be faced with a climate emergency. Such an emergency could take the form of a rapid shift in precipitation patterns, a collapse of the great ice sheets, the imminent triggering of strong climate system feedbacks, or perhaps the loss of valuable ecosystems. Over the past decade, we have used climate models to investigate the potential to reverse some of the effects of greenhouse gases in the atmosphere by deflecting some incoming sunlight back to space. This would probably be most cost-effectively achieved with the placement of small particles in or above the stratosphere. Our model simulations indicate that such geoengineering approaches could potentially bring our climate closer to the state is was in prior to the introduction of greenhouse gases. This talk will present much of what is known about such geoengineering approaches, and raise a range of issues likely to stimulate lively discussion. Speaker: Ken Caldeira Ken Caldeira is a scientist at the Carnegie Institution Department of Global Ecology and a Professor (by courtesy) at the Stanford University Department of Environmental and Earth System Sciences. Previously, he worked for 12 years in the Energy and Environment Directorate at the Lawrence Livermore National Laboratory (Department of Energy). His research interests include the numerical simulation of Earth's climate, carbon, and biogeochemistry; ocean acidification; climate emergency response systems; evaluating approaches to supplying environmentally-friendly energy services; ocean carbon sequestration; long-term evolution of climate and geochemical cycles; and marine biogeochemical cycles. Caldeira has a B.A. in Philosophy from Rutgers College and an M.S. and Ph.D. in Atmospheric Sciences from New York University.

  4. Acquisition Regulation

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    6 Rev. 1 Date 09/09/2015 Department of Energy No. FAL 2015-04 Rev. 1 Date 09/09/2015 Financial Assistance Regulations ACQUISITION/FINANCIAL ASSISTANCE LETTER This Acquisition/Financial Assistance Letter is issued under the authority of the Senior Procurement Executive of DOE. It is intended for use by procurement professionals of DOE, primarily Contracting Officers, and other officials of DOE that are involved in the acquisition process. Other parties are welcome to its information, but

  5. Environmental and societal consequences of a possible CO/sub 2/-induced climate change. Volume II, Part 8. Impacts of rising atmospheric carbon dioxide levels on agricultural growing seasons and crop water use efficiencies

    SciTech Connect (OSTI)

    Newman, J. E.

    1982-09-01

    The researchable areas addressed relate to the possible impacts of climate change on agricultural growing seasons and crop adaptation responses on a global basis. The research activities proposed are divided into the following two main areas of investigation: anticipated climate change impacts on the physical environmental characteristics of the agricultural growing seasons and, the most probable food crop responses to the possible changes in atmospheric CO/sub 2/ levels in plant environments. The main physical environmental impacts considered are the changes in temperature, or more directly, thermal energy levels and the growing season evapotranspiration-precipitation balances. The resulting food crop, commercial forest and rangeland species response impacts addressed relate to potential geographical shifts in agricultural growing seasons as determined by the length in days of the frost free period, thermal energy changes and water balance changes. In addition, the interaction of possible changes in plant water use efficiencies during the growing season in relationship to changing atmospheric CO/sub 2/ concentrations, is also considered under the scenario of global warming due to increases in atmospheric CO/sub 2/ concentration. These proposed research investigations are followed by adaptive response evaluations.

  6. Climate Change Science Program Issues Report on Climate Models | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Climate Change Science Program Issues Report on Climate Models Climate Change Science Program Issues Report on Climate Models July 31, 2008 - 2:40pm Addthis WASHINGTON, DC - The U.S. Climate Change Science Program (CCSP) today announced the release of the report "Climate Models: An Assessment of Strengths and Limitations," the 10th in a series of 21 Synthesis and Assessment Products (SAPs) managed by U.S. federal agencies. Developed under the leadership of the U.S.

  7. The effect of climate change, population distribution, and climate...

    Office of Scientific and Technical Information (OSTI)

    and China Citation Details In-Document Search Title: The effect of climate change, population distribution, and climate mitigation on building energy use in the U.S. and China A ...

  8. Laser-Induced Fluorescence

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Induced Fluorescence - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear

  9. NREL Climate Activities | Open Energy Information

    Open Energy Info (EERE)

    NREL Climate Activities Jump to: navigation, search Logo: Climate Activities at NREL Name Climate Activities at NREL AgencyCompany Organization National Renewable Energy...

  10. Regional Climate Change Webinar Presentation | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    Regional Climate Change Webinar presentation dated August 6, 2015. Regional Climate Change Webinar Presentation More Documents & Publications Regional Climate Change Webinar...

  11. Climate Change Assessment | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Climate Change Assessment Climate Change Assessment Climate Change Assessment 66climornlsalev2mjs.ppt (11.1 MB) More Documents & Publications 2014 Water Power Program Peer ...

  12. Climate Adaptation for Transportation | Open Energy Information

    Open Energy Info (EERE)

    Climate Adaptation for Transportation (Redirected from 03 Climate Adaptation for Transportation) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: 03 Climate Adaptation...

  13. European Climate Foundation (ECF) | Open Energy Information

    Open Energy Info (EERE)

    European Climate Foundation (ECF) Jump to: navigation, search Logo: European Climate Foundation (ECF) Name: European Climate Foundation (ECF) Address: Tournooiveld 4 2511 CX Place:...

  14. Climate Change Press Release | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Climate Change Press Release Community Leaders Institutes (CLIs) to be conducted to promote awareness of climate change impacts. CLI Climate Change Press Release (118.51 KB) More ...

  15. Climate System Response to External Forcings and Climate Change Projections

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in CCSM4 | Argonne Leadership Computing Facility Climate System Response to External Forcings and Climate Change Projections in CCSM4 Authors: Meehl, G.A., Washington, WM, Arblaster, JM, Hu, A., Teng, H., Tebaldi, C., White III, J.B., Strand Jr., WG Results are presented from experiments performed with the Community Climate System Model version 4 (CCSM4) for the Coupled Model Intercomparison Project phase 5 (CMIP5). These include multiple ensemble members of 20th century climate with

  16. ARM Climate Research Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages

    banner Home | People | Site Index Atmospheric Radiation Measurement Climate Research Facility US Department of Energy About Science Campaigns Sites Instruments Measurements Data News Publications Education Become a User Recovery Act Mission FAQ Outreach Displays History Organization Participants Facility Statistics Forms Contacts Research Themes LES ARM Symbiotic Simulation and Observation Workflow Research Highlights Journal Articles Collaborations Atmospheric System Research (ASR) ARM Science

  17. Climate Consulting | Open Energy Information

    Open Energy Info (EERE)

    Indonesia and China, gives assistance to companies and governments in climate change strategy plan. References: Climate Consulting1 This article is a stub. You can help OpenEI...

  18. OPEN HOUSE - Climate Prisms: Arctic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    OPEN HOUSE - Climate Prisms: Arctic OPEN HOUSE - Climate Prisms: Arctic WHEN: Jul 17, 2015 12:00 PM - 1:00 PM WHERE: Bradbury Science Museum 1350 Central Ave, Los Alamos, NM 87544, ...

  19. Climate Care | Open Energy Information

    Open Energy Info (EERE)

    Climate Care Jump to: navigation, search Name: Climate Care Place: Oxford, England, United Kingdom Zip: OX4 1RQ Sector: Carbon Product: Oxford-based carbon offsetting firm- making...

  20. Climate Policies | Open Energy Information

    Open Energy Info (EERE)

    Climate Policies Jump to: navigation, search This article is a stub. You can help OpenEI by expanding it. Retrieved from "http:en.openei.orgwindex.php?titleClimatePolicies&ol...

  1. ARM - Predictions of Climate Change

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TeachersTopic ListPredictions of Climate Change Outreach Home Room News Publications Traditional Knowledge Kiosks Barrow, Alaska Tropical Western Pacific Site Tours Contacts Students Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Predictions of Climate Change There are no accurate predictions of what will happen to earth's climate with an increase in greenhouse gases. The climate system is very complex, so that scientists

  2. Climate Vulnerabilities | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Climate Vulnerabilities Climate Vulnerabilities The Energy Sector's Vulnerabilities to Climatic Conditions x Impacts Due to... Increasing Temperatures Decreasing Water Availability Increasing Storms, Flooding, and Sea Level Rise See All Impacts Map locations are approximate. Find out more about this data here. Click and drag the map to read about each location

  3. Regulations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulations Regulations Security Reviews Click Here FOIA Appeals Click Here Whistleblower Protection Click Here Procedural Regulations Click Here Browse Title 10 Energy Click Here

  4. Atmospheric Radiation Measurement Climate Research Facility Operations...

    Office of Scientific and Technical Information (OSTI)

    Title: Atmospheric Radiation Measurement Climate Research Facility Operations Quarterly ... Atmospheric Radiation Measurement (ARM) Climate Research Facility fixed and mobile sites ...

  5. Climate Financing Options | Open Energy Information

    Open Energy Info (EERE)

    Guidemanual, Training materials Website: www.climatefinanceoptions.orgcfo Language: English References: Climate Finance Options1 New climate finance tool for...

  6. SEAB Climate Action Plan | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    SEAB Climate Action Plan SEAB Climate Action Plan A presentation on the Climate Action Plan presented by Dr. Jonathan Pershing, Deputy Assistant Secretary for Climate Change at the U.S. Department of Energy. Climate Action Plan (pdf) (998.5 KB) More Documents & Publications U.S. Energy Sector Vulnerabilities to Climate Change and Extreme Weather Climate Change and the U.S. Energy Sector: Regional Vulnerabilities and Resilience Solutions Climate Change: Energy and Community Impacts

  7. Princeton Plasma Physics Lab - Climate change

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    climate-change Climate change en Using powerful computers, physicists uncover mechanism that stabilizes plasma within tokamaks...

  8. Climate Funds Update | Open Energy Information

    Open Energy Info (EERE)

    Political Foundation Sector Climate Topics Finance Resource Type Training materials, Lessons learnedbest practices Website http:www.climatefundsupdate. References Climate...

  9. Drought-induced tree mortality accelerating in forests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Drought-induced tree mortality accelerating in forests Drought-induced tree mortality accelerating in forests Researchers at Los Alamos National Laboratory have found that drought and heat-induced tree mortality is accelerating in many forest biomes as a consequence of a warming climate in their paper published in the journal Nature Climate Change. May 19, 2015 Nathan McDowell examines an old, large tree, which could be impacted by future droughts. Nathan McDowell examines an old, large tree,

  10. Climate-Energy Nexus

    SciTech Connect (OSTI)

    Sayler, Gary; Gentry, Randall; Zhuang, Jie

    2010-07-01

    The 140-page published proceedings of the workshop include individual articles and PowerPoint slides for all workshop presentations. The proceedings also contain pertinent background information on the China-US Joint Research Center, partnering organizations, and workshop goals and objectives. Overall, the workshop increased the understanding of the impacts of climate change on energy use and renewable energy production as well as the complex relationships among land use, energy production, and ecological restoration. The workshop served as an international platform for scientists and students of different research backgrounds to develop a unified perspective on energy and climate relationships. Such understanding will benefit future cooperation between China and the US in mitigating global climate change. The workshop’s agenda, which is highly interdisciplinary, explored many potential opportunities for international collaboration in ecosystem management, climate modeling, greenhouse gas emissions, and bioenergy sustainability. International research groups have been suggested in the areas of genomes and biotechnology of energy plants, sustainable management of soil and water resources, carbon sequestration, and microbial processes for ecological cycles. The project has attracted considerable attention from institutes beyond the China-US Joint Research Center partners, and several of them (such as Institute of Qing-Tibet Plateau Research, Institute of Soil and Water Conservation, Institute of Applied Ecology, CAS) have expressed interest in joining the partnership. In addition, the workshop played a significant role in facilitating establishment of private-public partnerships between government and private bioenergy companies (such as L.R. Shugarts and Associates, Inc.), including seed providers (Blade Energy Crops, Thousand Oaks, CA), pilot demonstration projects at coal-producing cities (e.g., Huaibei, Anhui province, China), and the development of methodology

  11. Global Climate Models

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Page 2 - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy

  12. Climate Measurement & Modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Measurement & Modeling - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced

  13. Global Climate Models

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy Nuclear Energy

  14. Carbon dioxide and climate

    SciTech Connect (OSTI)

    Not Available

    1990-10-01

    Scientific and public interest in greenhouse gases, climate warming, and global change virtually exploded in 1988. The Department's focused research on atmospheric CO{sub 2} contributed sound and timely scientific information to the many questions produced by the groundswell of interest and concern. Research projects summarized in this document provided the data base that made timely responses possible, and the contributions from participating scientists are genuinely appreciated. In the past year, the core CO{sub 2} research has continued to improve the scientific knowledge needed to project future atmospheric CO{sub 2} concentrations, to estimate climate sensitivity, and to assess the responses of vegetation to rising concentrations of CO{sub 2} and to climate change. The Carbon Dioxide Research Program's goal is to develop sound scientific information for policy formulation and governmental action in response to changes of atmospheric CO{sub 2}. The Program Summary describes projects funded by the Carbon Dioxide Research Program during FY 1990 and gives a brief overview of objectives, organization, and accomplishments.

  15. Charge regulation circuit

    DOE Patents [OSTI]

    Ball, Don G.

    1992-01-01

    A charge regulation circuit provides regulation of an unregulated voltage supply in the range of 0.01%. The charge regulation circuit is utilized in a preferred embodiment in providing regulated voltage for controlling the operation of a laser.

  16. Variable temperature seat climate control system

    DOE Patents [OSTI]

    Karunasiri, Tissa R.; Gallup, David F.; Noles, David R.; Gregory, Christian T.

    1997-05-06

    A temperature climate control system comprises a variable temperature seat, at least one heat pump, at least one heat pump temperature sensor, and a controller. Each heat pump comprises a number of Peltier thermoelectric modules for temperature conditioning the air in a main heat exchanger and a main exchanger fan for passing the conditioned air from the main exchanger to the variable temperature seat. The Peltier modules and each main fan may be manually adjusted via a control switch or a control signal. Additionally, the temperature climate control system may comprise a number of additional temperature sensors to monitor the temperature of the ambient air surrounding the occupant as well as the temperature of the conditioned air directed to the occupant. The controller is configured to automatically regulate the operation of the Peltier modules and/or each main fan according to a temperature climate control logic designed both to maximize occupant comfort during normal operation, and minimize possible equipment damage, occupant discomfort, or occupant injury in the event of a heat pump malfunction.

  17. Dynamics of Arctic and Sub-Arctic Climate and Atmospheric Circulation: Diagnosis of Mechanisms and Biases Using Data Assimilation

    SciTech Connect (OSTI)

    Eric T. DeWeaver

    2010-02-17

    The overall goal of work performed under this grant is to enhance understanding of simulations of present-day climate and greenhouse gas-induced climate change. The examination of present-day climate also includes diagnostic intercomparison of model simulations and observed mean climate and climate variability using reanalysis and satellite datasets. Enhanced understanding is desirable 1) as a prerequisite for improving simulations; 2) for assessing the credibility of model simulations and their usefulness as tools for decision support; and 3) as a means to identify robust behaviors which commonly occur over a wide range of models, and may yield insights regarding the dominant physical mechanisms which determine mean climate and produce climate change. A further objective is to investigate the use of data assimilation as a means for examining and correcting model biases. Our primary focus is on the Arctic, but the scope of the work was expanded to include the global climate system.

  18. Playing the odds: Climate change risks transform utility plans

    SciTech Connect (OSTI)

    Tennis, M.W.

    1996-12-31

    Cost and uncertainty analyses conducted jointly by the Union of Concerned Scientists and World Resource Institute regarding climate change policy and regulations are presented in this paper. A utility model was developed to help determine whether action was required in the near term by the electric industry and policy makers to reduce carbon emissions. The cost and carbon dioxide emissions resulting from four case studies are tabulated. Analysis of the results shows that explicit consideration of climate change uncertainty can provide an economic justification for investing in low carbon resources at above market costs. A number of specific recommendations are made in the paper. 2 figs., 3 tabs.

  19. U.S. Mayor's Climate Protection Agreement: Climate Action Handbook...

    Open Energy Info (EERE)

    Action Handbook offers examples of actions that local governments can take to reduce global warming emissions and implement the commitments for climate protection called out...

  20. Regulators, Requirements, Statutes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Regulators, Requirements, Statutes Regulators, Requirements, Statutes The Laboratory must comply with environmental laws and regulations that apply to Laboratory operations. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email Environmental laws and regulations LANL complies with more than 30 state and federal regulations and policies designed to protect human health and the environment. Regulators Regulators Environmental

  1. Climate change effects on international stability : a white paper.

    SciTech Connect (OSTI)

    Murphy, Kathryn; Taylor, Mark A.; Fujii, Joy; Malczynski, Leonard A.; McNamara, Laura A.; Reinert, Rhonda K.; Sprigg, James A.; Backus, George A.; Boslough, Mark Bruce Elrick

    2004-12-01

    This white paper represents a summary of work intended to lay the foundation for development of a climatological/agent model of climate-induced conflict. The paper combines several loosely-coupled efforts and is the final report for a four-month late-start Laboratory Directed Research and Development (LDRD) project funded by the Advanced Concepts Group (ACG). The project involved contributions by many participants having diverse areas of expertise, with the common goal of learning how to tie together the physical and human causes and consequences of climate change. We performed a review of relevant literature on conflict arising from environmental scarcity. Rather than simply reviewing the previous work, we actively collected data from the referenced sources, reproduced some of the work, and explored alternative models. We used the unfolding crisis in Darfur (western Sudan) as a case study of conflict related to or triggered by climate change, and as an exercise for developing a preliminary concept map. We also outlined a plan for implementing agents in a climate model and defined a logical progression toward the ultimate goal of running both types of models simultaneously in a two-way feedback mode, where the behavior of agents influences the climate and climate change affects the agents. Finally, we offer some ''lessons learned'' in attempting to keep a diverse and geographically dispersed group working together by using Web-based collaborative tools.

  2. Climate Change | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Science & Innovation » Climate Change Climate Change May 31, 2016 Global Energy Leaders Gather in California to Drive Clean Energy Development and Deployment Goal of meetings will be to expand international collaboration in clean energy research, development, demonstration and deployment to combat climate change. May 27, 2016 Secretary Moniz sits with Under Secretary of Commerce for Oceans & Atmosphere and NOAA Administrator Dr. Kathy Sullivan (center) and Energy Department Senior

  3. Climate Consultant | Open Energy Information

    Open Energy Info (EERE)

    Climate Consultant AgencyCompany Organization: United States Department of Energy Sector: Energy Focus Area: Buildings, Energy Efficiency, Solar, Wind Resource Type: Dataset,...

  4. Climate Strategy | Open Energy Information

    Open Energy Info (EERE)

    Strategy Jump to: navigation, search Name: Climate Strategy Place: Madrid, Spain Zip: 28006 Sector: Efficiency Product: Madrid-based consulting firm specialising in projects in...

  5. Renewable Energy and Climate Change

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Renewable Energy and Climate Change Symposium in Honor of 2009 and 2010 ACS Fellows in ... Engineering Chemistry -- Cellulose and Renewable Materials, Chemicals, Fuels, and Energy ...

  6. Climate Change | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Highlights substantial growing efforts to support developing countries in the global response to climate change. Also details the financial assistance, education programs, and ...

  7. Climate Leadership Conference (Seattle, WA)

    Broader source: Energy.gov [DOE]

    Sustainability leaders from the private, public, academic, and non-profit communities meet to explore market transformation, carbon management, and building climate resilience on an annual basis.

  8. Climate change and the Arctic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate change and the Arctic Climate change and the Arctic WHEN: May 19, 2016 5:30 PM - 7:00 PM WHERE: UnQuarked Wine Room 145 Central Park Square, Los Alamos, New Mexico 87544 USA CONTACT: Linda Anderman (505) 665-9196 CATEGORY: Bradbury INTERNAL: Calendar Login Event Description Join us for convivial discussion on May 19 at 5:30 p.m. at UnQuarked Cathy Wilson, who heads the Lab's Atmosphere, Climate and Ecosystem Science team, is working to better understand what happens when warming climate

  9. Electric vehicle climate control

    SciTech Connect (OSTI)

    Dauvergne, J.

    1994-04-01

    EVs have insufficient energy sources for a climatic comfort system. The heat rejection of the drivetrain is dispersed in the vehicle (electric motor, batteries, electronic unit for power control). Its level is generally low (no more than 2-kW peaks) and variable according to the trip profile, with no heat rejection at rest and a maximum during regenerative braking. Nevertheless, it must be used for heating. It is not realistic to have the A/C compressor driven by the electric traction motor: the motor does not operate when the vehicle is at rest, precisely when maximum cooling power is required. The same is true for hybrid vehicles during electric operation. It is necessary to develop solutions that use stored onboard energy either from the traction batteries or specific storage source. In either case, it is necessary to design the climate control system to use the energy efficiently to maximize range and save weight. Heat loss through passenger compartment seals and the walls of the passenger compartment must be limited. Plastic body panes help to reduce heat transfer, and heat gain is minimized with insulating glazing. This article describes technical solutions to solve the problem of passenger thermal comfort. However, the heating and A/C systems of electrically operated vehicles may have marginal performance at extreme outside temperatures.

  10. Climate Model Output Rewriter

    Energy Science and Technology Software Center (OSTI)

    2004-06-21

    CMOR comprises a set of FORTRAN 90 dunctions that can be used to produce CF-compliant netCDF files. The structure of the files created by CMOR and the metadata they contain fulfill the requirements of many of the climate community’s standard model experiments (which are referred to here as "MIPS", which stands for "model intercomparison project", including, for example, AMIP, CMIP, CFMIP, PMIP, APE, and IPCC scenario runs), CMOR was not designed to serve as anmore » all-purpose wfiter of CF-compliant netCDF files, but simply to reduce the effort required to prepare and manage MIP data. Although MIPs encourage systematic analysis of results across models, this is only easy to do if the model output is written in a common format with files structured similarly and with sufficient metadata uniformly stored according to a common standard. Individual modeling groups store their data in different ways. but if a group can read its own data with FORTRAN, then it should easily be able to transform the data, using CMOR, into the common format required by the MIPs, The adoption of CMOR as a standard code for exchanging climate data will facilitate participation in MIPs because after learning how to satisfy the output requirements of one MIP, it will be easy to prepare output for the other MIPs.« less

  11. Climate Change and National Security

    SciTech Connect (OSTI)

    Malone, Elizabeth L.

    2013-02-01

    Climate change is increasingly recognized as having national security implications, which has prompted dialogue between the climate change and national security communities – with resultant advantages and differences. Climate change research has proven useful to the national security community sponsors in several ways. It has opened security discussions to consider climate as well as political factors in studies of the future. It has encouraged factoring in the stresses placed on societies by climate changes (of any kind) to help assess the potential for state stability. And it has shown that, changes such as increased heat, more intense storms, longer periods without rain, and earlier spring onset call for building climate resilience as part of building stability. For the climate change research community, studies from a national security point of view have revealed research lacunae, for example, such as the lack of usable migration studies. This has also pushed the research community to consider second- and third-order impacts of climate change, such as migration and state stability, which broadens discussion of future impacts beyond temperature increases, severe storms, and sea level rise; and affirms the importance of governance in responding to these changes. The increasing emphasis in climate change science toward research in vulnerability, resilience, and adaptation also frames what the intelligence and defense communities need to know, including where there are dependencies and weaknesses that may allow climate change impacts to result in security threats and where social and economic interventions can prevent climate change impacts and other stressors from resulting in social and political instability or collapse.

  12. Task Force on Climate Preparedness and Resilience Announces Tribal...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Task Force on Climate Preparedness and Resilience Announces Tribal Climate Resilience Program Task Force on Climate Preparedness and Resilience Announces Tribal Climate Resilience ...

  13. China-Climate Change Research Center | Open Energy Information

    Open Energy Info (EERE)

    China-Climate Change Research Center (Redirected from ClimateWorks-China Climate Change Research Center) Jump to: navigation, search Name China-Climate Change Research Center...

  14. Adams County, Washington ASHRAE 169-2006 Climate Zone | Open...

    Open Energy Info (EERE)

    ASHRAE 169-2006 Climate Zone Jump to: navigation, search County Climate Zone Place Adams County, Washington ASHRAE Standard ASHRAE 169-2006 Climate Zone Number Climate Zone...

  15. Climate VISION Progress Report 2007 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Climate VISION Progress Report 2007 Climate VISION Progress Report 2007 There is a growing recognition that climate change cannot be dealt with effectively in isolation Climate ...

  16. Evaluating climate models: Should we use weather or climate observations?

    SciTech Connect (OSTI)

    Oglesby, Robert J; Erickson III, David J

    2009-12-01

    Calling the numerical models that we use for simulations of climate change 'climate models' is a bit of a misnomer. These 'general circulation models' (GCMs, AKA global climate models) and their cousins the 'regional climate models' (RCMs) are actually physically-based weather simulators. That is, these models simulate, either globally or locally, daily weather patterns in response to some change in forcing or boundary condition. These simulated weather patterns are then aggregated into climate statistics, very much as we aggregate observations into 'real climate statistics'. Traditionally, the output of GCMs has been evaluated using climate statistics, as opposed to their ability to simulate realistic daily weather observations. At the coarse global scale this may be a reasonable approach, however, as RCM's downscale to increasingly higher resolutions, the conjunction between weather and climate becomes more problematic. We present results from a series of present-day climate simulations using the WRF ARW for domains that cover North America, much of Latin America, and South Asia. The basic domains are at a 12 km resolution, but several inner domains at 4 km have also been simulated. These include regions of complex topography in Mexico, Colombia, Peru, and Sri Lanka, as well as a region of low topography and fairly homogeneous land surface type (the U.S. Great Plains). Model evaluations are performed using standard climate analyses (e.g., reanalyses; NCDC data) but also using time series of daily station observations. Preliminary results suggest little difference in the assessment of long-term mean quantities, but the variability on seasonal and interannual timescales is better described. Furthermore, the value-added by using daily weather observations as an evaluation tool increases with the model resolution.

  17. Pacific Northwest Climate Science Conference

    Broader source: Energy.gov [DOE]

    The Pacific Northwest Climate Science Conference brings together more than 250 researchers and practitioners from around the region to discuss science results, challenges, and solutions related to the impacts of climate on people, natural resources, and infrastructure in the Pacific Northwest.

  18. Mississippi Climate & Hydrology Conference

    SciTech Connect (OSTI)

    Lawford, R.; Huang, J.

    2002-05-01

    The GEWEX Continental International Project (GCIP), which started in 1995 and completed in 2001, held its grand finale conference in New Orleans, LA in May 2002. Participants at this conference along with the scientists funded through the GCIP program are invited to contribute a paper to a special issue of Journal of Geophysical Research (JGR). This special JGR issue (called GCIP3) will serve as the final report on scientific research conducted by GCIP investigators. Papers are solicited on the following topical areas, but are not limited to, (1) water energy budget studies; (2) warm season precipitation; (3) predictability and prediction system; (4) coupled land-atmosphere models; (5) climate and water resources applications. The research areas cover observations, modeling, process studies and water resources applications.

  19. Climate Zone Number 5 | Open Energy Information

    Open Energy Info (EERE)

    Climate Zone Number 5 Jump to: navigation, search A type of climate defined in the ASHRAE 169-2006 standard. Climate Zone Number 5 is defined as Cool- Humid(5A) with IP Units 5400...

  20. City of Boulder- Climate Action Plan Fund

    Broader source: Energy.gov [DOE]

    Note: As of 2015, the Climate Action Plan is now referred to as the Climate Commitment. In November 2015, Boulder voters approved an extension of the  Climate Action Plan tax through 2020, with...

  1. DOE Climate Change Adaptation Training (Richland, WA)

    Office of Energy Efficiency and Renewable Energy (EERE)

    This free training is a primer on climate science, identifying climate hazards, conducting vulnerability assessments, leveraging climate change data and tools and understanding the energy-water-food nexus.

  2. ATNI Tribal Leaders Summit on Climate Change

    Broader source: Energy.gov [DOE]

    The Affiliated Tribes of Northwest Indians is hosting the Tribal Leaders Summit on Climate Change. This two-day conference will discuss climate change impacts, policy on climate change, tribal...

  3. ATNI Tribal Leaders Summit on Climate Change

    Broader source: Energy.gov [DOE]

    The Affiliated Tribes of Northwest Indians is hosting the Tribal Leaders Summit on Climate Change. This two-day conference will discuss climate change impacts, policy on climate change, tribal needs, funding opportunities, and more.

  4. 2014 DOE Climate Change Adaptation Plan

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    4 U.S. Department of Energy June 2014 DOE Climate Change Adaptation Plan Table of Contents Climate Change Adaptation Plan ................................................................................................................................2 Impetus for Action ..................................................................................................................................................2 The DOE Mission and Climate Change Adaptation

  5. Climate variability and climate change vulnerability and adaptation. Workshop summary

    SciTech Connect (OSTI)

    Bhatti, N.; Cirillo, R.R.; Dixon, R.K.

    1995-12-31

    Representatives from fifteen countries met in Prague, Czech Republic, on September 11-15, 1995, to share results from the analysis of vulnerability and adaptation to global climate change. The workshop focused on the issues of global climate change and its impacts on various sectors of a national economy. The U.N. Framework Convention on Climate Change (FCCC), which has been signed by more than 150 governments worldwide, calls on signatory parties to develop and communicate measures they are implementing to respond to global climate change. An analysis of a country`s vulnerability to changes in the climate helps it identify suitable adaptation measures. These analyses are designed to determine the extent of the impacts of global climate change on sensitive sectors such as agricultural crops, forests, grasslands and livestock, water resources, and coastal areas. Once it is determined how vulnerable a country may be to climate change, it is possible to identify adaptation measures for ameliorating some or all of the effects.The objectives of the vulnerability and adaptation workshop were to: The objectives of the vulnerability and adaptation workshop were to: Provide an opportunity for countries to describe their study results; Encourage countries to learn from the experience of the more complete assessments and adjust their studies accordingly; Identify issues and analyses that require further investigation; and Summarize results and experiences for governmental and intergovernmental organizations.

  6. Climate Action Champions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Initiatives » Climate Action Champions Climate Action Champions Climate Action Champions The White House launched the Climate Action Champions (CAC) Initiative in December 2014 with the U.S. Department of Energy (DOE) as lead Agency. The Administration expanded the Initiative in December 2015 through a strategic partnership with the Corporation for National Community Service (CNCS). PROGRAM POLICY OBJECTIVES The Climate Action Champions Initiative supports local and tribal government climate

  7. Atmospheric Radiation Measurement Climate Research Facility | Argonne

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    National Laboratory Atmospheric Radiation Measurement Climate Research Facility Argonne scientists study climate change 1 of 22 Argonne scientists study climate change The U.S. Department of Energy's Office of Science provided $60 million in ARRA funding for climate research to the Atmospheric Radiation Measurement (ARM) Climate Research Facility, a DOE national user facility that has been operating climate observing sites around the world for nearly two decades. These sites help scientists

  8. Climate Change Adaptation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Climate Change Adaptation Climate Change Adaptation Mission The Climate Change Adaption team affirms the overall DOE commitment to plan for and manage the short- and long-term effects of climate change, as deemed appropriate for LM operations and approved by LM, as defined in: Executive Order (EO) 13693, Planning for Federal Sustainability in the Next Decade, and EO 13653, Preparing the United States for the Impacts of Climate Change The team endorses the President's Climate Action Plan,

  9. Climate Change: Science and Policy Robert...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Entering the Cauldron of Climate Change: Science and Policy Robert Rosner University of ... of the American Physical Society "climate statement" - I chaired the Panel on ...

  10. Climate, Ocean and Sea Ice Modeling (COSIM)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Earth, Space Sciences Climate, Ocean and Sea Ice Modeling (COSIM) Climate, Ocean and Sea Ice Modeling (COSIM) The COSIM project develops advanced ocean and ice models for ...

  11. Climate Perspectives: Change in the Terrestrial Arctic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Perspectives: Change in the Terrestrial Arctic Climate Perspectives An interactive exploration of Arctic climate science through prisms of the visual arts, literary arts, info-vis, ...

  12. Climate Change Adaptation Technical Fact Sheet: Contaminated...

    Office of Environmental Management (EM)

    of potential climate change vulnerabilities and (2) presenting possible adaptation measures that may be considered to increase a remedy's resilience to climate change impacts. ...

  13. Regional Climate Vulnerabilities and Resilience Solutions | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regional Climate Vulnerabilities and Resilience Solutions Regional Climate Vulnerabilities and Resilience Solutions This interactive map is not viewable in your browser. Please ...

  14. Climate Action Plan | OpenEI Community

    Open Energy Info (EERE)

    actions that the administration believes will mitigate the environmental and economic costs of climate change. Obama's six Climate Action Initiatives: 1. Phasing out Fossil Fuels...

  15. California Climate Action Registry | Open Energy Information

    Open Energy Info (EERE)

    Climate Action Registry Jump to: navigation, search Name: California Climate Action Registry Place: Los Angeles, California Zip: 90014 Product: Los Angeles-based NPO which develops...

  16. The Climate Registry | Open Energy Information

    Open Energy Info (EERE)

    North America should partner with The Climate Registry as a cost effective central repository or clearinghouse for reporting andor tracking GHG data." "Members of The Climate...

  17. Atmospheric Radiation Measurement Climate Research Facility Operations...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    27 Atmospheric Radiation Measurement Climate Research Facility Operations Quarterly Report ... DOESC-ARM-16-027 Atmospheric Radiation Measurement Climate Research Facility Operations ...

  18. AUDIT REPORT Atmospheric Radiation Measurement Climate Research...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Atmospheric Radiation Measurement Climate Research Facility OAI-M-16-10 May 2016 U.S. ... Audit Report on the "Atmospheric Radiation Measurement Climate Research Facility" ...

  19. Atmospheric Radiation Measurement Climate Research Facility Operations...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7 Atmospheric Radiation Measurement Climate Research Facility Operations Quarterly Report ... DOESC-ARM-16-037 Atmospheric Radiation Measurement Climate Research Facility Operations ...

  20. Atmospheric Radiation Measurement Climate Research Facility Operations...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    01 Atmospheric Radiation Measurement Climate Research Facility Operations Quarterly Report ... DOESC-ARM-16-001 Atmospheric Radiation Measurement Climate Research Facility Operations ...

  1. Atmospheric Radiation Measurement Climate Research Facility Operations...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9 Atmospheric Radiation Measurement Climate Research Facility Operations Quarterly Report ... DOESC-ARM-15-069 Atmospheric Radiation Measurement Climate Research Facility Operations ...

  2. Climate Financing for Cities | Open Energy Information

    Open Energy Info (EERE)

    Framework1 "Cities in a Post-2012 Climate Policy Framework: Climate Financing for City Development? Views from Local Governments, Experts, and Businesses" This study...

  3. Climate Technology Initiative Training Courses | Open Energy...

    Open Energy Info (EERE)

    Training Courses Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Climate Technology Initiative Training Courses AgencyCompany Organization: Climate Technology...

  4. Climate Investment Funds | Open Energy Information

    Open Energy Info (EERE)

    Climate Fund (SCF), Forest Investment Program (FIP) Pilot Program for Climate Resilience (PPCR) Program for Scaling Up Renewable Energy in Low Income Countries (SREP)...

  5. Uncertainty Quantification in Climate Modeling - Discovering...

    Office of Scientific and Technical Information (OSTI)

    in Climate Modeling - Discovering Sparsity and Building Surrogates. Citation Details In-Document Search Title: Uncertainty Quantification in Climate Modeling - Discovering ...

  6. Climate Technology Initiative (CTI) | Open Energy Information

    Open Energy Info (EERE)

    search Logo: Climate Technology Initiative Name: Climate Technology Initiative Place: Japan Year Founded: 1995 Website: www.climatetech.net Coordinates: 36.204824,...

  7. Assessing Climate Change Impacts, Vulnerability and Adaptation...

    Open Energy Info (EERE)

    Climate Change Impacts, Vulnerability and Adaptation: The Case of Pantabangan-Carranglan Watershed Jump to: navigation, search Name Assessing Climate Change Impacts, Vulnerability...

  8. Climate Change Simulations with CCSM & CESM

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Change Simulations with CCSM & CESM Climate Change Simulations with CCSM & CESM Key Challenges: Perform fundamental research on the processes that influence the natural...

  9. Committee on Climate Change | Open Energy Information

    Open Energy Info (EERE)

    Committee on Climate Change Jump to: navigation, search Name: Committee on Climate Change Place: United Kingdom Product: String representation "As a key part o ... 2020 and 2050."...

  10. London Climate Change Agency | Open Energy Information

    Open Energy Info (EERE)

    Climate Change Agency Jump to: navigation, search Name: London Climate Change Agency Place: London, Greater London, United Kingdom Zip: SE1 8AA Product: Agency responsible for...

  11. Global Climate Change Institute | Open Energy Information

    Open Energy Info (EERE)

    Change Institute Jump to: navigation, search Name: Global Climate Change Institute Place: Tsinghua University, Beijing Municipality, China Zip: 100084 Product: Global Climate...

  12. Brazil Interministerial Commission on Global Climate Change ...

    Open Energy Info (EERE)

    Interministerial Commission on Global Climate Change Jump to: navigation, search Name: Brazil Interministerial Commission on Global Climate Change Place: Distrito Federal...

  13. Buildings and Climate Change | Open Energy Information

    Open Energy Info (EERE)

    and Climate Change Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Buildings and Climate Change AgencyCompany Organization: United Nations Environment Programme...

  14. Technologies for Climate Change Mitigation: Transport Sector...

    Open Energy Info (EERE)

    Technologies for Climate Change Mitigation: Transport Sector Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Technologies for Climate Change Mitigation: Transport Sector...

  15. Mainstreaming Climate Change Adaptation into Development Planning...

    Open Energy Info (EERE)

    Climate Change Adaptation into Development Planning: A Guide for Practitioners Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Mainstreaming Climate Change Adaptation...

  16. Office of Climate Change | Open Energy Information

    Open Energy Info (EERE)

    Change Jump to: navigation, search Name: Office of Climate Change Place: United Kingdom Product: UK government organisation that supports analytical work on climate change and the...

  17. Atmospheric Radiation Measurement Climate Research Facility Annual...

    Office of Scientific and Technical Information (OSTI)

    Atmospheric Radiation Measurement Climate Research Facility Annual Report 2006 Citation Details In-Document Search Title: Atmospheric Radiation Measurement Climate Research ...

  18. Symbiosis: Addressing Biomass Production Challenges and Climate...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Symbiosis: Addressing Biomass Production Challenges and Climate Change Symbiosis: Addressing Biomass Production Challenges and Climate Change This presentation was the opening ...

  19. Climate Energy LLC | Open Energy Information

    Open Energy Info (EERE)

    Climate Energy LLC Jump to: navigation, search Name: Climate Energy LLC Place: Medfield, Massachusetts Zip: 2052 Product: Develops and markets micro-combined heat power systems for...

  20. Presidential Climate Action Project | Open Energy Information

    Open Energy Info (EERE)

    Page Edit with form History Presidential Climate Action Project Jump to: navigation, search Name: Presidential Climate Action Project Place: Denver, Colorado Zip: 80217-3364...

  1. Climate Adaptation for Transportation | Open Energy Information

    Open Energy Info (EERE)

    Climate Adaptation for Transportation Jump to: navigation, search Tool Summary LAUNCH TOOL Name: 03 Climate Adaptation for Transportation AgencyCompany Organization: AASHTO...

  2. Atmosclear Climate Club | Open Energy Information

    Open Energy Info (EERE)

    Atmosclear Climate Club Jump to: navigation, search Name: Atmosclear Climate Club Place: Northborough, Massachusetts Zip: 1532 Product: AtmosClear is an offset provider that sells...

  3. Climate Bridge Ltd | Open Energy Information

    Open Energy Info (EERE)

    Bridge Ltd Jump to: navigation, search Name: Climate Bridge Ltd Place: Shanghai, Shanghai Municipality, China Zip: 200031 Product: Climate Bridge Ltd is an international company...

  4. E ON Climate Renewables | Open Energy Information

    Open Energy Info (EERE)

    ON Climate Renewables Jump to: navigation, search Name: E.ON Climate & Renewables Place: Dusseldorf, North Rhine-Westphalia, Germany Sector: Renewable Energy Product:...

  5. ARM - Lesson Plans: Historical Climate Statistics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Historical Climate Statistics Outreach Home Room News Publications Traditional Knowledge ... Teachers' Toolbox Lesson Plans Lesson Plans: Historical Climate Statistics Objective The ...

  6. Climate Action Tracker | Open Energy Information

    Open Energy Info (EERE)

    References: Climate Action Tracker1 "This "Climate Action Tracker" is an independent science-based assessment, which tracks the emission commitments and actions of countries. The...

  7. Natural Climate Systems | Open Energy Information

    Open Energy Info (EERE)

    search Name: Natural Climate Systems Place: Spain Product: Develops bioclimatic architecture projects. References: Natural Climate Systems1 This article is a stub. You can...

  8. Training for Climate Adaptation in Conservation

    Broader source: Energy.gov [DOE]

    The Wildlife Conservation Society and the Northern Institute of Applied Climate Science are hosting this two-day training for climate adaptation.

  9. Plants found to regulate leaf temperature to boost carbon uptake

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Plants found to regulate leaf temperature to boost carbon uptake Plants found to regulate leaf temperature to boost carbon uptake The research offers promise for refining Earth system models that help predict climate change impacts and feedbacks. August 30, 2016 The thermal traits of a leaf, critical for photosynthesis, may be under strong evolutionary selection that occurs in response to environmental temperatures. Here a thermal leaf image details temperature variation, which greatly affects

  10. Photoperiodic Regulation of the Seasonal Pattern of Photosynthetic Capacity and the Implications for Carbon Cycling

    SciTech Connect (OSTI)

    Bauerle, William L.; Oren, Ram; Way, Danielle A.; Qian, Song S.; Stoy, Paul C.; Thornton, Peter E; Bowden, Joseph D.; Hoffman, Forrest M; Reynolds, Robert F.

    2012-01-01

    Although temperature is an important driver of seasonal changes in photosynthetic physiology, photoperiod also regulates leaf activity. Climate change will extend growing seasons if temperature cues predominate, but photoperiod-controlled species will show limited responsiveness to warming. We show that photoperiod explains more seasonal variation in photosynthetic activity across 23 tree species than temperature. Although leaves remain green, photosynthetic capacity peaks just after summer solstice and declines with decreasing photoperiod, before air temperatures peak. In support of these findings, saplings grown at constant temperature but exposed to an extended photoperiod maintained high photosynthetic capacity, but photosynthetic activity declined in saplings experiencing a naturally shortening photoperiod; leaves remained equally green in both treatments. Incorporating a photoperiodic correction of photosynthetic physiology into a global-scale terrestrial carbon-cycle model significantly improves predictions of seasonal atmospheric CO{sub 2} cycling, demonstrating the benefit of such a function in coupled climate system models. Accounting for photoperiod-induced seasonality in photosynthetic parameters reduces modeled global gross primary production 2.5% ({approx}4 PgC y{sup -1}), resulting in a >3% ({approx}2 PgC y{sup -1}) decrease of net primary production. Such a correction is also needed in models estimating current carbon uptake based on remotely sensed greenness. Photoperiod-associated declines in photosynthetic capacity could limit autumn carbon gain in forests, even if warming delays leaf senescence.