Sample records for red blood cells

  1. Viscoelastic transient of confined Red Blood Cells

    E-Print Network [OSTI]

    Gaël Prado; Alexander Farutin; Chaouqi Misbah; Lionel Bureau

    2014-09-17T23:59:59.000Z

    The unique ability of a red blood cell to flow through extremely small microcapillaries depends on the viscoelastic properties of its membrane. Here, we study in vitro the response time upon flow startup exhibited by red blood cells confined into microchannels. We show that the characteristic transient time depends on the imposed flow strength, and that such a dependence gives access to both the effective viscosity and the elastic modulus controlling the temporal response of red cells. A simple theoretical analysis of our experimental data, validated by numerical simulations, further allows us to compute an estimate for the two-dimensional membrane viscosity of red blood cells, $\\eta_{mem}^{2D}\\sim 10^{-7}$ N$\\cdot$s$\\cdot$m$^{-1}$. By comparing our results with those from previous studies, we discuss and clarify the origin of the discrepancies found in the literature regarding the determination of $\\eta_{mem}^{2D}$, and reconcile seemingly conflicting conclusions from previous works.

  2. Red Blood Cell Segmentation from SEM Images Joost Vromen

    E-Print Network [OSTI]

    McCane, Brendan

    Red Blood Cell Segmentation from SEM Images Joost Vromen Human Media Interaction University Microscope image of red blood cells. We use a second order polynomial model and a simple Bayesian approach sample images involving more than 11000 red blood cells. I. INTRODUCTION There is considerable evidence

  3. Reversibility of Red blood Cell deformation

    E-Print Network [OSTI]

    Maria Zeitz; Pierre Sens

    2011-11-22T23:59:59.000Z

    The ability of cells to undergo reversible shape changes is often crucial to their survival. For Red Blood Cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may react irreversibly to mechanical perturbations because of tensile stress in their cytoskeleton. The transient polymerization of protein fibers inside the cell seen in sickle cell anemia or a transient external force can trigger the formation of a cytoskeleton-free membrane protrusion of micrometer dimensions. The complex relaxation kinetics of the cell shape is shown to be responsible for selecting the final state once the perturbation is removed, thereby controlling the reversibility of the deformation. In some case, tubular protrusion are expected to relax via a peculiar "pearling instability".

  4. Microfluidic devices for analysis of red blood cell mechanical properties

    E-Print Network [OSTI]

    Bow, Hansen Chang

    2010-01-01T23:59:59.000Z

    Decreased deformability of human red blood cells (RBCs) is both a cause of disease and biomarker for disease (1). To traverse blood capillaries, the biconcave disk-shaped RBC must deform dramatically, since the diameter ...

  5. Anisotropic light scattering of individual sickle red blood cells

    E-Print Network [OSTI]

    Kim, Youngchan

    We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped sickle RBCs ...

  6. Deformability of Plasmodium falciparum parasitized red blood cells

    E-Print Network [OSTI]

    Mills, John Philip, Ph. D. Massachusetts Institute of Technology

    2007-01-01T23:59:59.000Z

    The biophysical properties of the human red blood cell (RBC) permit large deformations required for passage through narrow capillaries and spleen sinusoids. Several pathologic conditions alter RBC deformability that can ...

  7. Lipid bilayer and cytoskeletal interactions in a red blood cell

    E-Print Network [OSTI]

    Peng, Zhangli

    We study the biomechanical interactions between the lipid bilayer and the cytoskeleton in a red blood cell (RBC) by developing a general framework for mesoscopic simulations. We treated the lipid bilayer and the cytoskeleton ...

  8. Kit for the selective labeling of red blood cells in whole blood with .sup.9 TC

    DOE Patents [OSTI]

    Srivastava, Suresh C. (Setauket, NY); Babich, John W. (Redhill Surrey, GB2); Straub, Rita (Brookhaven, NY); Richards, Powell (New Bern, NC)

    1992-01-01T23:59:59.000Z

    Disclosed herein are a method and kit for the preparation of .sup.99m Tc labeled red blood cells using whole blood in a closed sterile system containing stannous tin in a form such that it will enter the red blood cells and be available therein for reduction of technetium.

  9. Kit for the selective labeling of red blood cells in whole blood with [sup 99]Tc

    DOE Patents [OSTI]

    Srivastava, S.C.; Babich, J.W.; Straub, R.; Richards, P.

    1992-05-26T23:59:59.000Z

    Disclosed herein are a method and kit for the preparation of [sup 99m]Tc labeled red blood cells using whole blood in a closed sterile system containing stannous tin in a form such that it will enter the red blood cells and be available therein for reduction of technetium. No Drawings

  10. Method for determining properties of red blood cells

    DOE Patents [OSTI]

    Gourley, Paul L. (Albuquerque, NM)

    2001-01-01T23:59:59.000Z

    A method for quantifying the concentration of hemoglobin in a cell, and indicia of anemia, comprises determining the wavelength of the longitudinal mode of a liquid in a laser microcavity; determining the wavelength of the fundamental transverse mode of a red blood cell in the liquid in the laser microcavity; and determining if the cell is anemic from the difference between the wavelength of the longitudinal mode and the fundamental transverse mode. In addition to measuring hemoglobin, the invention includes a method using intracavity laser spectroscopy to measure the change in spectra as a function of time for measuring the influx of water into a red blood cell and the cell's subsequent rupture.

  11. Blood pressure and red blood cell magnesium, potassium, and calcium responses to dietary fats 

    E-Print Network [OSTI]

    Wehrman, Noreen Elaine

    1993-01-01T23:59:59.000Z

    for the degree of MASTER OF SCIENCE August 1993 Major Subject: Nutrition BLOOD PRESSURE AND RED BLOOD CELL MAGNESIUM, POTASSIUM, AND CALCIUM RESPONSES TO DIETARY FATS A Thesis by NOREEN ELAINE WEHRMAN Submitted to Texas A&M University in partial.... Edwards (Head of Department) August 1993 Major Subject: Nutrition ABSTRACT Blood Pressure and Red Blood Cell Magnesium, Potassium, and Calcium Responses to Dietary Fats, (August 1993) Noreen Elaine Wehrman, B. S. , Pennsylvania State University...

  12. Non-linear mechanical response of the Red Blood Cell

    E-Print Network [OSTI]

    Young-Zoon Yoon; Jurij Kotar; Gilwon Yoon; Pietro Cicuta

    2007-10-17T23:59:59.000Z

    We measure the dynamical mechanical properties of human red blood cells. Single cell response is measured with optical tweezers. We investigate both the stress relaxation following a fast deformation, and the effect of varying the strain rate. We find a power law decay of the stress as a function of time, down to a plateau stress, and a power law increase of the cell's elasticity as a function of the strain rate. Interestingly, the exponents of these quantities violate the linear superposition principle, indicating a nonlinear response. We propose that this is due to breaking of a fraction of the crosslinks during the deformation process. The Soft Glassy Rheology Model accounts for the relation between the exponents we observe experimentally. This picture is consistent with recent models of bond remodeling in the red blood cell's molecular structure. Our results imply that the blood cell's mechanical behavior depends critically on the deformation process.

  13. Multiscale Modeling of Red Blood Cell Mechanics and Blood Flow in Malaria

    E-Print Network [OSTI]

    Fedosov, Dmitry A.

    Red blood cells (RBCs) infected by a Plasmodium parasite in malaria may lose their membrane deformability with a relative membrane stiffening more than ten-fold in comparison with healthy RBCs leading to potential capillary ...

  14. The relevance of red blood cell deformability in the pathophysiology of blood disorders

    E-Print Network [OSTI]

    Huang, Sha, Ph. D. Massachusetts Institute of Technology

    2014-01-01T23:59:59.000Z

    Red blood cells (RBCs) play a crucial role in delivering oxygen to the body tissues. During the 120 days of their lifespan, average RBCs would circulate for approximately 500,000 times and undergo repeated deformations in ...

  15. Modeling Red Blood Cell and Iron Dynamics in Patients with Chronic Kidney Disease

    E-Print Network [OSTI]

    Modeling Red Blood Cell and Iron Dynamics in Patients with Chronic Kidney Disease H. T. Banks1, that stimulates red blood cell (RBC) production. Without intervention, patients suffer from anemia. Patients treatment. Keywords: mathematical model, mathematical biology, erythropoiesis, erythrocyte, red blood cell

  16. Modeling Red Blood Cell and Iron Dynamics in Patients Undergoing Periodic EPO and Iron Treatments

    E-Print Network [OSTI]

    Modeling Red Blood Cell and Iron Dynamics in Patients Undergoing Periodic EPO and Iron Treatments H in the kidneys, that stimulates red blood cell (RBC) production. Without intervention, patients suffer from, erythrocyte, red blood cell, chronic kidney disease, dialysis, iron, neocytolysis, hepcidin, EPO, hemoglobin e

  17. Method using CO for extending the useful shelf-life of refrigerated red blood cells

    DOE Patents [OSTI]

    Bitensky, M.W.

    1995-12-19T23:59:59.000Z

    A method is disclosed using CO for extending the useful shelf-life of refrigerated red blood cells. Carbon monoxide is utilized for stabilizing hemoglobin in red blood cells to be stored at low temperature. Changes observed in the stored cells are similar to those found in normal red cell aging in the body, the extent thereof being directly related to the duration of refrigerated storage. Changes in cell buoyant density, vesiculation, and the tendency of stored cells to bind autologous IgG antibody directed against polymerized band 3 IgG, all of which are related to red blood cell senescence and increase with refrigerated storage time, have been substantially slowed when red blood cells are treated with CO. Removal of the carbon monoxide from the red blood cells is readily and efficiently accomplished by photolysis in the presence of oxygen so that the stored red blood cells may be safely transfused into a recipient. 5 figs.

  18. Method using CO for extending the useful shelf-life of refrigerated red blood cells

    DOE Patents [OSTI]

    Bitensky, Mark W. (Los Alamos, NM)

    1995-01-01T23:59:59.000Z

    Method using CO for extending the useful shelf-life of refrigerated red blood cells. Carbon monoxide is utilized for stabilizing hemoglobin in red blood cells to be stored at low temperature. Changes observed in the stored cells are similar to those found in normal red cell aging in the body, the extent thereof being directly related to the duration of refrigerated storage. Changes in cell buoyant density, vesiculation, and the tendency of stored cells to bind autologous IgG antibody directed against polymerized band 3 IgG, all of which are related to red blood cell senescence and increase with refrigerated storage time, have been substantially slowed when red blood cells are treated with CO. Removal of the carbon monoxide from the red blood cells is readily and efficiently accomplished by photolysis in the presence of oxygen so that the stored red blood cells may be safely transfused into a recipient.

  19. Direct In Vivo Electrochemical Detection of Haemoglobin in Red Blood Cells

    E-Print Network [OSTI]

    Toh, Rou Jun

    The electrochemical behavior of iron ion in haemoglobin provides insight to the chemical activity in the red blood cell which is important in the field of hematology. Herein, the detection of haemoglobin in human red blood ...

  20. General coarse-grained red blood cell models: I. Mechanics

    E-Print Network [OSTI]

    Fedosov, Dmitry A; Karniadakis, George E

    2009-01-01T23:59:59.000Z

    We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which lead to accurate mechanical properties of realistic RBCs. Based on a semi-analytic theory linear and non-linear elastic properties of the RBC membrane can be matched with those obtained in optical tweezers stretching experiments. In addition, we develop a nearly stress-free model which avoids a number of pitfalls of existing RBC models, such as non-biconcave equilibrium shape and dependence of RBC mechanical properties on the triangulation quality. The proposed RBC model is suitable for use in many existing numerical methods, such as Lattice Boltzmann, Multiparticle Collision Dynamics, Immersed Boundary, etc.

  1. General coarse-grained red blood cell models: I. Mechanics

    E-Print Network [OSTI]

    Dmitry A. Fedosov; Bruce Caswell; George E. Karniadakis

    2009-05-01T23:59:59.000Z

    We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which lead to accurate mechanical properties of realistic RBCs. Based on a semi-analytic theory linear and non-linear elastic properties of the RBC membrane can be matched with those obtained in optical tweezers stretching experiments. In addition, we develop a nearly stress-free model which avoids a number of pitfalls of existing RBC models, such as non-biconcave equilibrium shape and dependence of RBC mechanical properties on the triangulation quality. The proposed RBC model is suitable for use in many existing numerical methods, such as Lattice Boltzmann, Multiparticle Collision Dynamics, Immersed Boundary, etc.

  2. Blood, sweat and tears : a case study of the development of cultured red blood cells for transfusion 

    E-Print Network [OSTI]

    King, Emma Katharine

    2013-11-27T23:59:59.000Z

    This thesis is an in-depth case study of an interdisciplinary, paradigm breaking, research team who are seeking to develop cultured red blood cells (RBCs) for transfusion using stem cells (known as the BloodPharma project). ...

  3. Method and kit for the selective labeling of red blood cells in whole blood with TC-99M

    DOE Patents [OSTI]

    Srivastava, Suresh C. (Setauket, NY); Babich, John W. (Redhill, GB2); Straub, Rita (Brookhaven, NY); Richards, Powell (New Bern, NC)

    1988-01-01T23:59:59.000Z

    Disclosed herein are a method and kit for the preparation of .sup.99m Tc labeled red blood cells using whole blood in a closed sterile system containing stannous tin in a form such that it will enter the red blood cells and be available therein for the reduction of technetium.

  4. Method and kit for the selective labeling of red blood cells in whole blood with Tc-99m

    DOE Patents [OSTI]

    Srivastava, S.C.; Babich, J.W.; Straub, R.; Richards, P.

    1988-07-05T23:59:59.000Z

    Disclosed herein are a method and kit for the preparation of [sup 99m]Tc labeled red blood cells using whole blood in a closed sterile system containing stannous tin in a form such that it will enter the red blood cells and be available for the reduction of technetium. No Drawings

  5. A model for red blood cells in simulations of large-scale blood flows

    E-Print Network [OSTI]

    Simone Melchionna

    2011-07-25T23:59:59.000Z

    Red blood cells (RBCs) are an essential component of blood. A method to include the particulate nature of blood is introduced here with the goal of studying circulation in large-scale realistic vessels. The method uses a combination of the Lattice Boltzmann method (LBM) to account for the plasma motion, and a modified Molecular Dynamics scheme for the cellular motion. Numerical results illustrate the quality of the model in reproducing known rheological properties of blood as much as revealing the effect of RBC structuring on the wall shear stress, with consequences on the development of cardiovascular diseases.

  6. CALCULATIONS OF OXYGEN TRANSPORT BY RED BLOOD CELLS

    E-Print Network [OSTI]

    Popel, Aleksander S.

    of RBCs (hematocrit) in the blood is small, in sickle cell anemia, for perioperative uses in surgery

  7. Rheology of dilute suspensions of vesicles and red blood cells

    E-Print Network [OSTI]

    Victoria Vitkova; Maud-Alix Mader; Chaouqi Misbah; Thomas Podgorski

    2007-07-29T23:59:59.000Z

    We present rheology experiments on dilute solutions of vesicles and red blood cells (RBC). Varying the viscosity ratio $\\lambda$ between internal and external fluids, the microscopic dynamics of suspended objects can be qualitatively changed from tank-treading ($tt$) to tumbling ($tb$). We find that in the tt regime the viscosity $\\eta$, decreases when $\\lambda$ increases, in contrast with droplet emulsions and elastic capsule theories which are sometimes invoked to model RBC dynamics. At a critical $\\lambda$ (close to the tt-tb transition) $\\eta$ exhibits a minimum before it increases in the tb regime. This is consistent with a recent theory for vesicles. This points to the nontrivial fact that the cytoskeleton in RBC does not alter the qualitative evolution of $\\eta$ and that, as far as rheology is concerned, vesicle models might be a better description.

  8. Euler buckling-induced folding and rotation of red blood cells in an optical trap

    E-Print Network [OSTI]

    Sharma, Shobhona

    Euler buckling-induced folding and rotation of red blood cells in an optical trap A Ghosha 005, India Abstract. We investigate the physics of an optically-driven micromotor of biological origin. When a single, live red blood cell is placed in an optical trap, the normal biconcave disk shape

  9. Quantifying the biophysical characteristics of Plasmodium-falciparum- parasitized red blood cells in microcirculation

    E-Print Network [OSTI]

    Fedosov, D. A.

    The pathogenicity of Plasmodium falciparum (Pf) malaria results from the stiffening of red blood cells (RBCs) and its ability to adhere to endothelial cells (cytoadherence). The dynamics of Pf-parasitized RBCs is studied ...

  10. Radiolabeled red blood cells: status, problems, and prospects

    SciTech Connect (OSTI)

    Srivastava, S.C.

    1983-01-01T23:59:59.000Z

    Radionuclidic labels for red cells can be divided into two main categories - cohort or pulse labels, and random labels. The random labels are incorporated into circulating cells of all ages and the labeling process is usually carried out in vitro. The red cell labels in predominant use involve random labeling and employ technetium-99m, chromium-51, indium-111, and gallium-68, roughly in that order. The extent of usefulness depends on the properties of the label such as the half-life, decay mode, and in-vivo stability, etc. Labeled cells can be used for red cell survival measurements when the half-life of the radionuclide is sufficiently long. The major portion of this article deals with random labels.

  11. Dynamic Modes of Red Blood Cells in Oscillatory Shear Flow

    E-Print Network [OSTI]

    Hiroshi Noguchi

    2010-06-12T23:59:59.000Z

    The dynamics of red blood cells (RBCs) in oscillatory shear flow was studied using differential equations of three variables: a shape parameter, the inclination angle $\\theta$, and phase angle $\\phi$ of the membrane rotation. In steady shear flow, three types of dynamics occur depending on the shear rate and viscosity ratio. i) tank-treading (TT): $\\phi$ rotates while the shape and $\\theta$ oscillate. ii) tumbling (TB): $\\theta$ rotates while the shape and $\\phi$ oscillate. iii) intermediate motion: both $\\phi$ and $\\theta$ rotate synchronously or intermittently. In oscillatory shear flow, RBCs show various dynamics based on these three motions. For a low shear frequency with zero mean shear rate, a limit-cycle oscillation occurs, based on the TT or TB rotation at a high or low shear amplitude, respectively. This TT-based oscillation well explains recent experiments. In the middle shear amplitude, RBCs show an intermittent or synchronized oscillation. As shear frequency increases, the vesicle oscillation becomes delayed with respect to the shear oscillation. At a high frequency, multiple limit-cycle oscillations coexist. For a high mean shear rate with small shear oscillation, the shape and $\\theta$ oscillate in the TT motion but only one attractor exists even at high shear frequencies. The measurement of these oscillatory modes is a promising tool for quantifying the viscoelasticity of RBCs and synthetic capsules.

  12. Combined Simulation and Experimental Study of Large Deformation of Red Blood Cells in Microfluidic Systems

    E-Print Network [OSTI]

    Quinn, David J.

    We investigate the biophysical characteristics of healthy human red blood cells (RBCs) traversing microfluidic channels with cross-sectional areas as small as 2.7 × 3 ?m. We combine single RBC optical tweezers and flow ...

  13. In Vivo Volume and Hemoglobin Dynamics of Human Red Blood Cells

    E-Print Network [OSTI]

    Malka, Roy

    Human red blood cells (RBCs) lose ~30% of their volume and ~20% of their hemoglobin (Hb) content during their ~100-day lifespan in the bloodstream. These observations are well-documented, but the mechanisms for these volume ...

  14. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

    DOE Patents [OSTI]

    Bitensky, M.W.; Yoshida, Tatsuro

    1997-04-29T23:59:59.000Z

    A method is disclosed using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time is achieved by removing oxygen from the red blood cells at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate. 4 figs.

  15. Applying a microfluidic 'deformability cytometry' to measure stiffness of malaria-infected red blood cells at body and febrile temperatures

    E-Print Network [OSTI]

    Huang, Sha, Ph. D. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    Red blood cells (RBCs) undergo repeated deformation as they traverse blood vessel, capillaries and splenic cords; RBC deformability is therefore crucial in maintaining normal blood circulation. During falciparum malaria, ...

  16. Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell Nathalie Lemonne1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Pointe-à-Pitre, 97157 Pointe-à-Pitre, Guadeloupe Running head: Avascular necrosis and sickle cell anemia in sickle cell anemia (SCA) remains unknown. Blood hyper-viscosity has been suggested as a factor involved1 Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell

  17. Blood . Author manuscript Does increased red blood cell deformability raise the risk for

    E-Print Network [OSTI]

    Boyer, Edmond

    for osteonecrosis in sickle cell anemia? Nathalie Lemonne 1 , Yann Lamarre 2 , Marc Romana 2 , Martin Mukisi The pathogenesis of osteonecrosis in sickle cell anemia (SCA) remains unknown. Blood hyper-viscosity has been

  18. Prolonged cold storage of red blood cells by oxygen removal and additive usage

    DOE Patents [OSTI]

    Bitensky, Mark W. (Boston, MA); Yoshida, Tatsuro (Newton, MA)

    1998-01-01T23:59:59.000Z

    Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials.

  19. Prolonged cold storage of red blood cells by oxygen removal and additive usage

    DOE Patents [OSTI]

    Bitensky, M.W.; Yoshida, Tatsuro

    1998-08-04T23:59:59.000Z

    Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4 C storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4 C for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials. 8 figs.

  20. Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas

    DOE Patents [OSTI]

    Bitensky, Mark W. (Los Alamos, NM); Yoshida, Tatsuro (Los Alamos, NM)

    1997-01-01T23:59:59.000Z

    Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.

  1. Torque-generating malaria-infected red blood cells in an optical trap

    E-Print Network [OSTI]

    Sharma, Shobhona

    Torque-generating malaria-infected red blood cells in an optical trap J.A. Dharmadhikari, S. Roy, A 005, India # atmol1@tifr.res.in Abstract: We have used optical tweezers to trap normal and Plasmodium emerge from our experiments. Firstly, while the optical field modifies both types of RBCs in the same

  2. Rotational behavior of red blood cells in suspension---a mesoscale simulation study

    E-Print Network [OSTI]

    Florian Janoschek; Francesca Mancini; Jens Harting; Federico Toschi

    2010-10-29T23:59:59.000Z

    The nature of blood as a suspension of red blood cells makes computational hemodynamics a demanding task. Our coarse-grained blood model, which builds on a lattice Boltzmann method for soft particle suspensions, enables the study of the collective behavior of the order of 10^6 cells in suspension. After demonstrating the viscosity measurement in Kolmogorov flow, we focus on the statistical analysis of the cell orientation and rotation in Couette flow. We quantify the average inclination with respect to the flow and the nematic order as a function of shear rate and hematocrit. We further record the distribution of rotation periods around the vorticity direction and find a pronounced peak in the vicinity of the theoretical value for free model cells even though cell-cell interactions manifest themselves in a substantial width of the distribution.

  3. Hyperemic peripheral red marrow in a patient with sickle cell anemia demonstrated on Tc-99m labeled red blood cell venography

    SciTech Connect (OSTI)

    Heiden, R.A.; Locko, R.C.; Stent, T.R. (Columbia Univ. College of Physicians and Surgeons, New York, NY (USA))

    1991-03-01T23:59:59.000Z

    A 25-year-old gravid woman, homozygous for sickle cell anemia, with a history of recent deep venous thrombosis, was examined using Tc-99m labeled red blood cell venography for recurrent thrombosis. Although negative for thrombus, the study presented an unusual incidental finding: the patient's peripheral bone marrow was hyperemic in a distribution consistent with peripheral red bone marrow expansion. Such a pattern has not been documented before using this technique. This report supports other literature that has demonstrated hyperemia of peripheral red bone marrow in other hemolytic anemias. This finding may ultimately define an additional role of scintigraphy in assessing the pathophysiologic status of the sickle cell patient.

  4. On study of nonlinear viscoelastic behavior of red blood cell membrane

    E-Print Network [OSTI]

    Horacio Castellini; Bibiana Riquelme; Patricia Foresto

    2007-03-15T23:59:59.000Z

    The linear viscoelastic behavior of the red blood cell membrane of mammal and human was studied in previous works proposing different experimental methods to determine their viscoelastic parameters. In the present work the nonlinear component of dynamic viscosity of the red blood cell membrane by nonlinear time series analysis is used. For such aim, it obtained time series of test in vitro of samples of humans and rats red blood cells using the Erythrodeformeter in oscillating regime. The signal filtrate suppresses any linear behavior as well as represented by a system of linear ordinary differential equations. The test shown as much in humans as in rats resonance frequencies associated to an attractor of unknown nature independently of excitation in the physiological range. The preliminary studies shown that attractor could be correspond to a complex form bull. These results allow to extend the present knowledge on dynamic of the cellular membrane to similar stimulus which happens in the blood circulation and it will allows to make better models of the same one.

  5. Cytoskeleton mediated effective elastic properties of model red blood cell membranes

    E-Print Network [OSTI]

    Rui Zhang; Frank L. H. Brown

    2008-06-24T23:59:59.000Z

    The plasma membrane of human red blood cells consists of a lipid bilayer attached to a regular network of underlying cytoskeletal polymers. We model this system at a dynamic coarse-grained level, treating the bilayer as an elastic sheet and the cytoskeletal network as a series of phantom entropic springs. In contrast to prior simulation efforts, we explicitly account for dynamics of the cytoskeletal network, both via motion of the protein anchors that attach the cytoskeleton to the bilayer and through breaking and reconnection of individual cytoskeletal filaments. Simulation results are explained in the context of a simple mean-field percolation model and comparison is made to experimental measurements of red blood cell fluctuation amplitudes.

  6. Surface-emitting superconductor laser spectroscopy for characterizing normal and sickled red blood cells

    SciTech Connect (OSTI)

    Gourley, P.L.; Meissner, K.E.; Brennan, T.M.; Hammons, B.E. [Sandia National Labs., Albuquerque, NM (United States); Gourley, M.F. [National Institutes of Health, Bethesda, MD (United States)

    1995-02-01T23:59:59.000Z

    We have developed a new intracavity laser technique that uses a living or a fixed cell as an integral component of the laser. The cells are placed on an AlGaAs/GaAs surface-emitting semiconductor wafer and covered with a glass dielectric mirror to form a laser resonator. In this arrangement, the cells serve as optical waveguides (or lens elements) to confine (or focus) light generated in the resonator by the semiconductor. Because of the high transparency, the cells aid the lasing process to generate laser light. This ultra sensitive laser provides a novel imaging/spectroscopic technique for histologic examination which we demonstrate with normal and sickled human red blood cells. Extremely high contrast microscopic images of the cells are observed near 830-850 nm. These images correspond to electromagnetic modes of cell structures and are sensitive to shape of the cell. Using a high resolution spectrometer, we resolve the light emitted from these images into very narrow spectral peaks associated with the lasing modes. Analysis of the spectra reveals that the distribution of peaks is quite different for normal and sickled red blood cells. This technique, in a more developed form, may be useful for the rapid analysis of other kinds of normal and abnormal cells.

  7. Lift and down-gradient shear-induced diffusion in Red Blood Cell suspensions

    E-Print Network [OSTI]

    Xavier Grandchamp; Gwennou Coupier; Aparna Srivastav; Christophe Minetti; Thomas Podgorski

    2013-02-24T23:59:59.000Z

    The distribution of Red Blood Cells in a confined channel flow is inhomogeneous and shows a marked depletion near the walls due to a competition between migration away from the walls and shear-induced diffusion resulting from interactions between particles. We investigated the lift of RBCs in a shear flow near a wall and measured a significant lift velocity despite the tumbling motion of cells. We also provide values for the collective and anisotropic shear-induced diffusion of a cloud of RBCs, both in the direction of shear and in the direction of vorticity. A generic down-gradient subdiffusion characterized by an exponent 1/3 is highlighted.

  8. How does confinement affect the dynamics of viscous vesicles and red blood cells?

    E-Print Network [OSTI]

    Badr Kaoui; Timm Krüger; Jens Harting

    2012-07-16T23:59:59.000Z

    Despite its significance in microfluidics, the effect of confinement on the transition from the tank-treading (steady motion) to the tumbling (unsteady motion) dynamical state of deformable micro-particles has not been studied in detail. In this paper, we investigate the dynamics of a single viscous vesicle under confining shear as a general model system for red blood cells, capsules, or viscous droplets. The transition from tank-treading to tumbling motion can be triggered by the ratio between internal and external fluid viscosities. Here, we show that the transition can be induced solely by reducing the confinement, keeping the viscosity contrast constant. The observed dynamics results from the variation of the relative importance of viscous-, pressure-, and lubrication-induced torques exerted upon the vesicle. Our findings are of interest for designing future experiments or microfluidic devices: the possibility to trigger the tumbling-to-tank-treading transition either by geometry or viscosity contrast alone opens attractive possibilities for microrheological measurements as well as the detection and diagnosis of diseased red blood cells in confined flow.

  9. Euler buckling in red blood cells: An optically driven biological micromotor

    E-Print Network [OSTI]

    A. Ghosh; Supurna Sinha; J. A. Dharmadhikari; S. Roy; A. K. Dharmadhikari; J. Samuel; S. Sharma; D. Mathur

    2005-07-28T23:59:59.000Z

    We investigate the physics of an optically-driven micromotor of biological origin. A single, live red blood cell, when placed in an optical trap folds into a rod-like shape. If the trapping laser beam is circularly polarized, the folded RBC rotates. A model based on the concept of buckling instabilities captures the folding phenomenon; the rotation of the cell is simply understood using the Poincar\\`e sphere. Our model predicts that (i) at a critical intensity of the trapping beam the RBC shape undergoes large fluctuations and (ii) the torque is proportional to the intensity of the laser beam. These predictions have been tested experimentally. We suggest a possible mechanism for emergence of birefringent properties in the RBC in the folded state.

  10. Blood pressure and red blood cell magnesium, potassium, and calcium responses to dietary fats

    E-Print Network [OSTI]

    Wehrman, Noreen Elaine

    1993-01-01T23:59:59.000Z

    of hypertension. The role of dietary fats in blood pressure regulation is being studied more closely, with careful consideration to their actions on prostaglandin synthesis, membrane fluidity and permeability, and electrolyte balance. This study examined... Page 111 . V1 V11 . 1X Problem Identification. Electrolytes. Magnesium . The Role of Magnesium and Ion Transport . The Relationship Between Magnesium and Potassium. The Relationship Between Magnesium and Calcium. The Relationship Between...

  11. Homeostasis and volume regulation in the Plasmodium falciparum infected red blood cell

    E-Print Network [OSTI]

    Mauritz, Jakob Martin Andreas

    2011-06-07T23:59:59.000Z

    enabled individual cells to be trapped and manipulated optomechanically in microfluidic channels. Combined, these methods offered a unique insight into the homeostatic and rheological behaviour of malaria-infected red cells. The results were analysed...

  12. artificial red blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    as long-circulating drug carriers 3. RBC as red blood cells to evade the immune system Ronnie Hongbo Fang, Che-Ming Jack Hu & Liangfang Zhang-circulating entities, red blood...

  13. Stiffening of Red Blood Cells Induced by Disordered Cytoskeleton Structures: A Joint Theory-experiment Study

    E-Print Network [OSTI]

    Lipeng Lai; Xiaofeng Xu; Chwee Teck Lim; Jianshu Cao

    2015-02-14T23:59:59.000Z

    The functions and elasticities of the cell are largely related to the structures of the cytoskeletons underlying the lipid bi-layer. Among various cell types, the Red Blood Cell (RBC) possesses a relatively simple cytoskeletal structure. Underneath the membrane, the RBC cytoskeleton takes the form of a two dimensional triangular network, consisting of nodes of actins (and other proteins) and edges of spectrins. Recent experiments focusing on the malaria infected RBCs (iRBCs) showed that there is a correlation between the elongation of spectrins in the cytoskeletal network and the stiffening of the iRBCs. Here we rationalize the correlation between these two observations by combining the worm-like chain (WLC) model for single spectrins and the Effective Medium Theory (EMT) for the network elasticity. We specifically focus on how the disorders in the cytoskeletal network affect its macroscopic elasticity. Analytical and numerical solutions from our model reveal that the stiffness of the membrane increases with increasing end-to-end distances of spectrins, but have a non-monotonic dependence on the variance of the end-to-end distance distributions. These predictions are verified quantitively by our AFM and micropipette aspiration measurements of iRBCs. The model may, from a molecular level, provide guidelines for future identification of new treatment methods for RBC related diseases, such as malaria infection.

  14. High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction tomography

    E-Print Network [OSTI]

    Kim, Kyoohyun

    We present high-resolution optical tomographic images of human red blood cells (RBC) parasitized by malaria-inducing Plasmodium falciparum (Pf)-RBCs. Three-dimensional (3-D) refractive index (RI) tomograms are reconstructed ...

  15. amphiuma red blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    clay) with human red blood cells Engineering Websites Summary: in the manufacture of oil adsorbants as fertilizer carriers, and as an additive to liquid suspensions; however,...

  16. adjunct red blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    clay) with human red blood cells Engineering Websites Summary: in the manufacture of oil adsorbants as fertilizer carriers, and as an additive to liquid suspensions; however,...

  17. autologous red blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    clay) with human red blood cells Engineering Websites Summary: in the manufacture of oil adsorbants as fertilizer carriers, and as an additive to liquid suspensions; however,...

  18. Shear-response of the spectrin dimer-tetramer equilibrium in the red blood cell membrane

    SciTech Connect (OSTI)

    An, Xiuli; Lecomte, M. Christine; Chasis, Joel Anne; Mohandas, Narla; Gratzer, Walter

    2003-06-18T23:59:59.000Z

    The red cell membrane derives its elasticity and resistance to mechanical stresses from the membrane skeleton, a network composed of spectrin tetramers. These are formed by the head-to-head association of pairs of heterodimers attached at their ends to junctional complexes of several proteins. Here we examine the dynamics of the spectrin dimer-dimer association in the intact membrane. We show that univalent fragments of spectrin, containing the dimer self-association site, will bind to spectrin on the membrane and thereby disrupt the continuity of the protein network. This results in impairment of the mechanical stability of the membrane. When, moreover, the cells are subjected to a continuous low level of shear, even at room temperature, the incorporation of the fragments and the consequent destabilization of the membrane are greatly accentuated. It follows that a modest shearing force, well below that experienced by the red cell in the circulation, is sufficient to sever dimer-dimer links in the network. Our results imply (1) that the membrane accommodates the enormous distortions imposed on it during the passage of the cell through the micro vasculature by means of local dissociation of spectrin tetramers to dimers, (2) that the network in situ is in a dynamic state and under goes a ''breathing'' action of tetramer dissociation and re-formation.

  19. Predicting dynamics and rheology of blood flow: A comparative study of multiscale and low-dimensional models of red blood cells

    SciTech Connect (OSTI)

    Pan, Wenxiao; Fedosov, Dmitry A.; Caswell, Bruce; Karniadakis, George E.

    2011-05-27T23:59:59.000Z

    In this work we compare the predictive capability of two mathematical models for red blood cells (RBCs) focusing on blood flow in capillaries and arterioles. Both RBC models as well as their corresponding blood flows are based on the dissipative particle dynamics (DPD) method, a coarse-grained molecular dynamics approach. The first model employs a multiscale description of the RBC (MS-RBC), with its membrane represented by hundreds or even thousands of DPD-particles connected by springs into a triangular network in combination with out-of-plane elastic bending resistance. Extra dissipation within the network accounts for membrane viscosity, while the characteristic biconcave RBC shape is achieved by imposition of constraints for constant membrane area and constant cell volume. The second model is based on a low-dimensional description (LD-RBC) constructed as a closed torus-like ring of only 10 large DPD colloidal particles. They are connected into a ring by worm-like chain (WLC) springs combined with bending resistance. The LD-RBC model can be fitted to represent the entire range of nonlinear elastic deformations as measured by optical-tweezers for healthy and for infected RBCs in malaria. MS-RBCs suspensions model the dynamics and rheology of blood flow accurately for any size vessel but this approach is computationally expensive above 100 microns. Surprisingly, the much more economical suspensions of LD-RBCs also capture the blood flow dynamics and rheology accurately except for vessels with sizes comparable to RBC diameter. In particular, the LD-RBC suspensions are shown to properly capture the experimental data for the apparent viscosity of blood and its cell-free layer (CFL) in tube flow. Taken together, these findings suggest a hierarchical approach in modeling blood flow in the arterial tree, whereby the MS-RBC model should be employed for capillaries and arterioles below 100 microns, the LD-RBC model for arterioles, and the continuum description for arteries.

  20. Red blood cells and other non-spherical capsules in shear flow: oscillatory dynamics and the tank-treading-to-tumbling transition

    E-Print Network [OSTI]

    J. M. Skotheim; T. W. Secomb

    2006-05-26T23:59:59.000Z

    We consider the motion of red blood cells and other non-spherical microcapsules dilutely suspended in a simple shear flow. Our analysis indicates that depending on the viscosity, membrane elasticity, geometry and shear rate, the particle exhibits either tumbling, tank-treading of the membrane about the viscous interior with periodic oscillations of the orientation angle, or intermittent behavior in which the two modes occur alternately. For red blood cells, we compute the complete phase diagram and identify a novel tank-treading-to-tumbling transition at low shear rates. Observations of such motions coupled with our theoretical framework may provide a sensitive means of assessing capsule properties.

  1. PHYSICAL REVIEW E 85, 051904 (2012) Reversibility of red blood cell deformation

    E-Print Network [OSTI]

    Sens, Pierre

    2012-01-01T23:59:59.000Z

    inside the cell seen in sickle cell anemia or a transient external force can trigger the formation deformation are reversible. In sickle cell anemia, a mutation in the hemoglobin (Hg) gene leads

  2. Combined Simulation and Experimental Study of Large Deformation of Red Blood Cells in Microfluidic Systems

    E-Print Network [OSTI]

    Dao, Ming

    such as spherocytosis, elliptocytosis, and ovalocytosis, as well as diseases such as diabetes, sickle cell anemia

  3. Effects of carbon dioxide and pH variations in vitro on blood respiratory functions, red blood cell volume, transmembrane pH gradients, and sickling in sickle cell anemia

    SciTech Connect (OSTI)

    Ueda, Y.; Bookchin, R.M.

    1984-08-01T23:59:59.000Z

    An examination was made of the O/sub 2/ affinity, Bohr effect, transmembrane pH gradient, mean cell hemoglobin concentration, and red blood cell sickling at half O/sub 2/ saturation in whole sickle cell (SS) and normal (AA) blood during CO/sub 2/ titration and acid-base titration at three Pco/sub 2/ levels, 10, 40, and 80 mm Hg. The CO/sub 2/-induced Bohr effect of SS blood was considerably larger than normal (maximum, 0.91, referred to cell pH) and similar to that found with acid-base titration at Pco/sub 2/ of 40. In contrast to AA blood, SS blood showed an increased O/sub 2/ affinity when Pco/sub 2/ was raised from 40 to 80, and at half O/sub 2/ saturation showed biphasic or sigmoid Bohr curves, a fall in transmembrane pH gradient with rising Pco/sub 2/, and an absence of the normal cell volume increase at low pH and Pco/sub 2/. Sickling of SS cells at half O/sub 2/ saturation was partly inhibited by increasing Pc/sub 2/, particularly in the higher pH ranges. These complex differences in the behavior of SS blood are interpreted in terms of the balancing of several effects: the lowering of hemoglobin O/sub 2/-affinity by polymerization, low pH and increased CO/sub 2/ binding, inhibition of hemoglobin S polymerization by CO/sub 2/ binding to ..beta../sup s/-chain amino termini, differences between hemoglobin S and A in competitive binding of CO/sub 2/ and 2,3-diphosphoglycerate at different pH levels, and an increased net negative charge exhibited by intracellular deoxyhemoglobin S polymers. From a clinical standpoint, in the absence of hypoxia or acidosis, an increased blood Pco/sub 2/ might have a beneficial effect by inhibiting red blood cell sickling, whereas a metabolic acidosis, with low blood pH and Pco/sub 2/, would be very hazardous.

  4. adsol-preserved red blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    clay) with human red blood cells Engineering Websites Summary: in the manufacture of oil adsorbants as fertilizer carriers, and as an additive to liquid suspensions; however,...

  5. RESEARCH ARTICLE Open Access Impact of Herpes simplex virus load and red blood

    E-Print Network [OSTI]

    Boyer, Edmond

    RESEARCH ARTICLE Open Access Impact of Herpes simplex virus load and red blood cells in cerebrospinal fluid upon herpes simplex meningo-encephalitis outcome Julien Poissy1* , Karen Champenois2 , Anny Background: Herpes simplex encephalitis (HSE) often leads to severe disability or death. Factors usually

  6. A spectral boundary integral method for flowing blood cells Hong Zhao a

    E-Print Network [OSTI]

    Olson, Luke

    A spectral boundary integral method for flowing blood cells Hong Zhao a , Amir H.G. Isfahani January 2010 Keywords: Stokes flow Particle-mesh Ewald Red blood cells Spherical harmonics Boundary element methods a b s t r a c t A spectral boundary integral method for simulating large numbers of blood

  7. Osmotic water permeability of human red cells

    SciTech Connect (OSTI)

    Terwilliger, T.C.; Solomon, A.K.

    1981-05-01T23:59:59.000Z

    The osmotic water permeability of human red cells has been reexamined with a stopped-flow device and a new perturbation technique. Small osmotic gradients are used to minimize the systematic error caused by nonlinearities in the relationship between cell volume and light scattering. Corrections are then made for residual systematic error. Our results show that the hydraulic conductivity, Lp, is essentially independent of the direction of water flow and of osmolality in the range 184-365 mosM. the mean value of Lp obtained obtained was 1.8 +/- 0.1 (SEM) X 10-11 cm3 dyne -1 s-1.

  8. American Red Cross Blood Drive Hanford Health and Safety Exposition

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisiting the TWP TWPAlumni Alumni PARC/I-CARES CERTIFICATE INofNuclearAmericanLeoRed

  9. Effect of red blood cells on platelet aggregation

    E-Print Network [OSTI]

    Karniadakis, George E.

    This study briefly reviews the model that describes platelet behavior resulting in aggregation and thrombus formation. This is followed by an overview of the basics of the dissipative particle dynamics (DPD), the simulation ...

  10. 1. Introduction 2. Red blood cell (RBC)-based

    E-Print Network [OSTI]

    Zhang, Liangfang

    materials directly derived from RBCs. This method has been demonstrated to prolong particle systemic by the macrophages of the mononuclear phagocyte system (MPS). The advent of `stealth' nanoparticles has had a great

  11. Errata: Observation of dynamic subdomains in red blood cells

    E-Print Network [OSTI]

    Popescu, Gabriel

    This article was originally published online on 18 July 2006 without Michael S. Feld in the author list. In addition, there were errors in Eq. 3. The corrected equation appears below. All online versions of the article ...

  12. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, Charles L. (Downers Grove, IL); Thilly, William G. (Winchester, MA)

    1985-01-01T23:59:59.000Z

    A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.

  13. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    SciTech Connect (OSTI)

    Wu, Zhigang; Willing, Ben; Bjerketorp, Joakim; Jansson, Janet K.; Hjort, Klas

    2009-01-05T23:59:59.000Z

    We developed a new approach to separate bacteria from human blood cells based on soft inertial force induced migration with flow defined curved and focused sample flow inside a microfluidic device. This approach relies on a combination of an asymmetrical sheath flow and proper channel geometry to generate a soft inertial force on the sample fluid in the curved and focused sample flow segment to deflect larger particles away while the smaller ones are kept on or near the original flow streamline. The curved and focused sample flow and inertial effect were visualized and verified using a fluorescent dye primed in the device. First the particle behavior was studied in detail using 9.9 and 1.0 {micro}m particles with a polymer-based prototype. The prototype device is compact with an active size of 3 mm{sup 2}. The soft inertial effect and deflection distance were proportional to the fluid Reynolds number (Re) and particle Reynolds number (Re{sub p}), respectively. We successfully demonstrated separation of bacteria (Escherichia coli) from human red blood cells at high cell concentrations (above 10{sup 8}/mL), using a sample flow rate of up to 18 {micro}L/min. This resulted in at least a 300-fold enrichment of bacteria at a wide range of flow rates with a controlled flow spreading. The separated cells were proven to be viable. Proteins from fractions before and after cell separation were analyzed by gel electrophoresis and staining to verify the removal of red blood cell proteins from the bacterial cell fraction. This novel microfluidic process is robust, reproducible, simple to perform, and has a high throughput compared to other cell sorting systems. Microfluidic systems based on these principles could easily be manufactured for clinical laboratory and biomedical applications.

  14. Expansion of Human Cord Blood Hematopoietic Stem Cells for Transplantation

    E-Print Network [OSTI]

    Chou, Song

    A recent Science paper reported a purine derivative that expands human cord blood hematopoietic stem cells in culture ( Boitano et al., 2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome ...

  15. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, C.L.; Thilly, W.G.

    1999-08-10T23:59:59.000Z

    The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics. 3 figs.

  16. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, Charles L. (Marblehead, MA); Thilly, William G. (Winchester, MA)

    1999-01-01T23:59:59.000Z

    The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.

  17. The Centre for Blood Research Seminar Series

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Seminar Series Wednesday, April 24th, 2013 LSC 3 - Life Sciences Red Blood Cells" The glycoprotein, Band 3 or anion exchanger 1 (AE1) catalyzes the electro per cell, similar to Glycophorin A with which it interacts forming the Wright (Wr) blood group antigen

  18. New method for the selective labeling of erythrocytes in whole blood with Tc-99m

    DOE Patents [OSTI]

    Srivastava, S.C.; Babich, J.W.; Straub, R.; Richards, P.

    1984-01-27T23:59:59.000Z

    Method and kit are described for the preparation of /sup 99m/Tc labeled red blood cells using whole blood in a closed sterile system containing stannous tin in a form such that it will enter the red blood cells and be available therein for the reduction of technetium.

  19. The Centre for Blood Research Mohandas Narla DSc

    E-Print Network [OSTI]

    Strynadka, Natalie

    . Sickle cell anemia is a common inherited red cell disorder with high morbidity. We created mice found in humans with sickle cell disease including irreversibly sickled cells in peripheral blood, reduced red cell life span and resultant anemia and multiorgan pathology including renal and liver

  20. Increased phorbol 12,13-dibutyrate (PDBu) receptor function associated with sickle red cell membrane ghosts

    SciTech Connect (OSTI)

    Ramachandran, M.; Nair, C.N.; Abraham, E.C.

    1987-05-01T23:59:59.000Z

    The biological receptor for tumor-promoting phorbol esters has been identified as the CaS /phospholipid dependent enzyme, protein kinase C. In the red cell, this enzyme is mainly cytosolic but becomes translocated to the membrane if the cellular CaS is allowed to rise. Since cellular CaS in sickle red cells is high, it was reasoned that this enzyme may become more membrane-bound. In fact, the authors noticed a four-fold increase in the binding of TH-PDBu by membrane ghosts isolated from sickle red cells compared to normal red cells (pmoles PDBu bound/mg protein; normal = 0.3 vs sickle cell = 1.4). Attempts to assay the enzyme directly as phospholipid-activated TSP incorporation into the acid-precipitable membrane proteins also indicated a two-fold increase in the radiolabelling of sickle cell membrane ghosts. Autophosphorylation of membrane proteins and analysis of the phosphorylation profile by SDS-PAGE and autoradiography revealed phosphorylation predominantly of bands 3, 4.1 and 4.9 which are known protein kinase C substrates for the red cell enzyme. The increased membrane-associated protein kinase C in sickle red cells may have a bearing on the altered membrane properties reported in this condition.

  1. Physiological relevance of the changes in hemodynamics for circulating blood cells in

    E-Print Network [OSTI]

    103 Chapter 5 Physiological relevance of the changes in hemodynamics for circulating blood cells that these changes in the mechanical stimuli might have on the activation state of circulating blood cells have never the magnitude and duration of the shear stresses acting on blood cells circulating inside AAAs

  2. Mathematical Modeling of Blood Clotting: The Interplay of Coagulation Chemistry,

    E-Print Network [OSTI]

    Ciocan-Fontanine, Ionut

    Mathematical Modeling of Blood Clotting: The Interplay of Coagulation Chemistry, Platelet of a blood clot inside of a blood vessel, a process known as thrombosis, involves the intertwined processes, of aggregated platelets, fibrin polymer mesh, and trapped red and white blood cells. Thrombosis can be initiated

  3. Meandering through southern Spain, the Rio Tinto's blood red colour warns that this

    E-Print Network [OSTI]

    Gray, Matthew

    in Woods Hole to wonder how these microalgae prosper in acid (p. 2569). Messerli assumed that the acid if the microalgae maintain a neutral pH inside their cells. When they loaded a fluorescent pH-sensitive dye the microalgae deal with the onslaught of protons from the Rio Tinto, the team measured the microalgae

  4. Design of a numerical model for simulation of blood microcirculation and study of sickle cell disease

    E-Print Network [OSTI]

    Le Floch-Yin, François T. (François Thomas)

    2010-01-01T23:59:59.000Z

    Sickle cell disease is nowadays one of the most challenging blood diseases, where patients suffer from both chronic and acute episodes of painful medical conditions. In particular, unpredictable crises due to blood vessel ...

  5. ORIGINAL ARTICLE Blood Transfus DOI 10.2450/2012.0099-11

    E-Print Network [OSTI]

    Thomas, David D.

    blood bank cold storage, red cells progressively lose deformability and elasticity due to irreversible between the number of days of cold storage of packed red blood cells (PRBC) and adverse outcomes major biochemical events occurring during cold storage, in order to determine which changes may underlie

  6. Cerebral blood flow in sickle cell cerebrovascular disease

    SciTech Connect (OSTI)

    Huttenlocher, P.R.; Moohr, J.W.; Johns, L.; Brown, F.D.

    1984-05-01T23:59:59.000Z

    Cerebral blood flow (CBF) has been studied by the xenon-133 (/sup 133/Xe) inhalation method in 16 children with suspected sickle cell cerebrovascular disease. Abnormalities consisting of decreases in total, hemispheral, or regional CBF were found in 17 of 26 studies. Eleven studies performed immediately after stroke, transient ischemic attack, or depression of state of alertness showed abnormalities. In addition to confirming regional cerebrovascular insufficiency in children with stroke due to major cerebral artery occlusion, the method detected diffuse decrease in CBF in children with stupor, coma, and seizures who had normal angiographic findings. In contrast, six of seven studies obtained after exchange transfusion or during maintenance on hypertransfusion therapy showed normal findings. The difference between results in patients with acute neurologic disturbances and those receiving transfusion therapy was statistically significant (P less than .005). The data indicate that the /sup 133/Xe method reliably demonstrates cerebrovascular impairment in sickle cell disease. They also suggest that CBF changes in patients with sickle cell disease can be reversed by exchange transfusion and by hypertransfusion therapy. The /sup 133/Xe CBF method may be useful for following up children with sickle cell disease who are at high risk for recurrent stroke.

  7. Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae

    E-Print Network [OSTI]

    Krasnow, Mark A.

    Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae October 18, 2007) Insects have an open circulatory system in which the heart pumps blood (hemolymph) into the body cavity, where it directly bathes the internal organs and epidermis. The blood contains free

  8. Blood Circulatory System The circulatory system consists of

    E-Print Network [OSTI]

    Cochran-Stafira, D. Liane

    oxygen from the lungs and deliver it to tissues of the body. To pick up carbon dioxide from the tissues and unload it in the lungs. Red blood cells They contain many molecules of hemoglobin. Hemoglobin. When blood containing bicarbonate ions reaches the lungs, carbon dioxide diffuses out of the blood

  9. Investigation of blood cells migration in large stenosed artery 

    E-Print Network [OSTI]

    Shuib, Anis Suhaila

    2012-06-25T23:59:59.000Z

    Atherosclerosis is one of the main diseases responsible for the high global mortality rate involving heart and blood vessel disorders. The build-up of fatty materials in the inner wall of the human artery prevents ...

  10. Calcium accumulated by sickle cell anemia red cells does not affect their potassium (86Rb+) flux components

    SciTech Connect (OSTI)

    Ortiz, O.E.; Lew, V.L.; Bookchin, R.M.

    1986-03-01T23:59:59.000Z

    We investigate here the hypothesis that the high Ca content of sickle cell anemia (SS) red cells may produce a sustained activation of the Ca2+-dependent K+ permeability (Gardos effect) and that the particularly high Ca levels in the dense SS cell fraction rich in irreversibly sickled cells (ISCs) might account for the Na pump inhibition observed in these cells. We measured active and passive 86Rb+ influx (as a marker for K+) in density-fractionated SS cells before and after extraction of their excess Ca by exposure to the Ca ionophore (A23187) and ethylene glycol tetra-acetic acid and with or without adenosine triphosphate depletion or addition of quinine. None of these maneuvers revealed any evidence of a Ca2+-dependent K leak in SS discocytes or dense cells. Na pump inhibition in the dense SS cells was associated with normal activation by external K+ and a low Vmax that persisted after Ca extraction from the cells. These results are consistent with our recent findings that the excess Ca in these cells is compartmentalized in intracellular inside-out vesicles and unavailable as free Ca2+ to the inner membrane surface. Although the steady-state free cytoplasmic Ca2+ in oxygenated SS cells must be below the levels needed to activate the K+ channel, possible brief activation of the channels of some SS cells resulting from transient elevations of cell Ca2+ during deoxygenation-induced sickling cannot be excluded. The dense, ISC-rich SS cell fraction showed a Ca2+-independent increase in the ouabain-resistant, nonsaturable component of 86Rb+ influx that, if uncompensated by Na+ gain, could contribute to the dehydration of these cells.

  11. The effects of peritoneal dialysis fluid and its components on the differentiation of white blood cells into fibrocytes 

    E-Print Network [OSTI]

    Starke, Hannah

    2012-04-12T23:59:59.000Z

    the blood and develop into cells called fibrocytes. A blood protein called serum amyloid P (SAP) inhibits the development of fibrocytes. I investigated how the dialysis fluid and its separate salt components affect the development of fibrocytes. I found...

  12. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

    E-Print Network [OSTI]

    Chen, Qingfeng

    Adoptive transfer of human hematopoietic stem cells (HSCs) into mice lacking T, B and natural killer (NK) cells leads to development of human-blood lineage cells in the recipient mice (humanized mice). Although human B ...

  13. Technetium-99m white blood cell imaging: False-negative result in salmonella osteomyelitis associated with sickle cell disease

    SciTech Connect (OSTI)

    Guze, B.H.; Hawkins, R.A.; Marcus, C.S.

    1989-02-01T23:59:59.000Z

    The authors report a case of sickle cell anemia associated osteomyelitis where the Tc-99m white blood cell imaging was negative, and bone imaging showed increased uptake in the region in question. The reasons for the possible false-negative image are discussed.

  14. From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood-brain barrier?

    E-Print Network [OSTI]

    Liu, Linan; Eckert, Mark A; Riazifar, Hamidreza; Kang, Dong-Ku; Agalliu, Dritan; Zhao, Weian

    2013-01-01T23:59:59.000Z

    and function of the blood-brain barrier,” Neurobiology ofV. Zlokovic, “The blood-brain barrier in health and chroniccell biology of the blood- brain barrier,” Annual Review of

  15. ParaView Red Blood Cell Tutorial | Argonne Leadership Computing Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)IntegratedSpeeding access toTestPhysics LabInterconnection RiskMarch Study

  16. Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient

    E-Print Network [OSTI]

    Dao, Ming

    . 1. Introduction Sickle cell disease (SCD) or sickle cell anemia is an inherited autosomal bloodOptical measurement of biomechanical properties of individual erythrocytes from a sickle cell July 2012 Available online 20 July 2012 Keywords: Sickle cell disease Red blood cell Cell biomechanics

  17. Peripheral blood derived mononuclear cells enhance osteoarthritic human chondrocyte migration

    E-Print Network [OSTI]

    Hopper, Niina; Henson, Frances; Brooks, Roger; Ali, Erden; Rushton, Neil; Wardale, John

    2015-01-01T23:59:59.000Z

    gradients [44, 45]. Experiments in young animals have shown that chondrocyte migration affects tissue-engineered cartilage integration by activating the signal transduction pathways involving Src, PLC?1, and ERK1/2 [46]. In order to begin to investigate... from the National Institute for Health Research. Abbreviations ACTB, actin beta; B2M, beta-2 microglobulin; BMP, bone morphogenic protein; CAPN, calpain; CI, cell index; ECM, extracellular matrix; ERK, extracellular signal regulated kinases; FBS...

  18. Predicting human blood viscosity in silico

    SciTech Connect (OSTI)

    Fedosov, Dmitry A.; Pan, Wenxiao; Caswell, Bruce; Gompper, Gerhard; Karniadakis, George E.

    2011-07-19T23:59:59.000Z

    Cellular suspensions such as blood are a part of living organisms and their rheological and ?ow characteristics determine and affect majority of vital functions. The rheological and ?ow properties of cell suspensions are determined by collective dynamics of cells, their structure or arrangement, cell properties and interactions. We study these relations for blood in silico using a mesoscopic particle-based method and two different models (multi-scale/low-dimensional) of red blood cells. The models yield accurate quantitative predictions of the dependence of blood viscosity on shear rate and hematocrit. We explicitly model cell aggregation interactions and demonstrate the formation of reversible rouleaux structures resulting in a tremendous increase of blood viscosity at low shear rates and yield stress, in agreement with experiments. The non-Newtonian behavior of such cell suspensions (e.g., shear thinning, yield stress) is analyzed and related to the suspension’s microstructure, deformation and dynamics of single cells. We provide the ?rst quantitative estimates of normal stress differences and magnitude of aggregation forces in blood. Finally, the ?exibility of the cell models allows them to be employed for quantitative analysis of a much wider class of complex ?uids including cell, capsule, and vesicle suspensions.

  19. Severe proliferative retinopathy is associated with blood hyperviscosity in sickle cell hemoglobin-C disease but not in sickle cell anemia

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    -C disease but not in sickle cell anemia Clément Lemaire1 , Yann Lamarre2 , Nathalie Lemonne3 , Xavier Waltz2 with homozygous SCD (sickle cell anemia; SCA) and 27 with sickle cell hemoglobin-C disease (SCC). The patients with sickle cell anemia (SCA) [9]. The greater whole blood viscosity usually reported in SCC patients

  20. Separation of cancer cells from peripheral blood mononuclear cells using pH control and dielectrophoresis

    E-Print Network [OSTI]

    Pattanaik, Malisha

    2009-01-01T23:59:59.000Z

    DEP. According to theories on tumor cell survival in acidicproposed theory of increased cancer cell survival comparedzero percent survival. Therefore, according to the theory of

  1. ABO, D Blood Typing and Subtyping Using Plug-Based Microfluidics

    E-Print Network [OSTI]

    Ismagilov, Rustem F.

    ABO, D Blood Typing and Subtyping Using Plug-Based Microfluidics Timothy R. Kline, Matthew K-based microfluidic approach was used to perform multiple agglutination assays in parallel without cross-chip, a microfluidic device was designed to combine aqueous streams of antibody, buffer, and red blood cells (RBCs

  2. HEART AND BLOOD VESSELS CARDIOVASCULARCARDIOVASCULAR

    E-Print Network [OSTI]

    Cochran-Stafira, D. Liane

    HEART AND BLOOD VESSELS CARDIOVASCULARCARDIOVASCULAR SYSTEMSYSTEM SYSTEM COMPONENTS · Heart pumps blood though blood vessels where exchanges can take place with the interstitial fluid (between cells) · Heart and blood vessels regulate blood flow according to the needs of the body

  3. Radiation-Induced Micro-RNA Expression Changes in Peripheral Blood Cells of Radiotherapy Patients

    SciTech Connect (OSTI)

    Templin, Thomas; Paul, Sunirmal; Amundson, Sally A.; Young, Erik F. [Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Barker, Christopher A.; Wolden, Suzanne L. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Smilenov, Lubomir B., E-mail: lbs5@columbia.ed [Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States)

    2011-06-01T23:59:59.000Z

    Purpose: MicroRNAs (miRNAs), a class of noncoding small RNAs that regulate gene expression, are involved in numerous physiologic processes in normal and malignant cells. Our in vivo study measured miRNA and gene expression changes in human blood cells in response to ionizing radiation, to develop miRNA signatures that can be used as biomarkers for radiation exposure. Methods and Materials: Blood from 8 radiotherapy patients in complete remission 1 or 2 was collected immediately before and 4 hours after total body irradiation with 1.25 Gy x-rays. Both miRNA and gene expression changes were measured by means of quantitative polymerase chain reaction and microarray hybridization, respectively. Hierarchic clustering, multidimensional scaling, class prediction, and gene ontology analysis were performed to investigate the potential of miRNAs to serve as radiation biomarkers and to elucidate their likely physiologic roles in the radiation response. Results: The expression levels of 45 miRNAs were statistically significantly upregulated 4 hours after irradiation with 1.25 Gy x-rays, 27 of them in every patient. Nonirradiated and irradiated samples form separate clusters in hierarchic clustering and multidimensional scaling. Out of 223 differentially expressed genes, 37 were both downregulated and predicted targets of the upregulated miRNAs. Paired and unpaired miRNA-based classifiers that we developed can predict the class membership of a sample with unknown irradiation status, with accuracies of 100% when all 45 upregulated miRNAs are included. Both miRNA control of and gene involvement in biologic processes such as hemopoiesis and the immune response are increased after irradiation, whereas metabolic processes are underrepresented among all differentially expressed genes and the genes controlled by miRNAs. Conclusions: Exposure to ionizing radiation leads to the upregulation of the expression of a considerable proportion of the human miRNAome of peripheral blood cells. These miRNA expression signatures can be used as biomarkers of radiation exposure.

  4. Simulations of Blood Flow in Plain Cylindrical and Constricted Vessels with Single Cell Resolution

    E-Print Network [OSTI]

    Florian Janoschek; Federico Toschi; Jens Harting

    2011-05-31T23:59:59.000Z

    Understanding the physics of blood is challenging due to its nature as a suspension of soft particles and the fact that typical problems involve different scales. This is valid also for numerical investigations. In fact, many computational studies either neglect the existence of discrete cells or resolve relatively few cells very accurately. The authors recently developed a simple and highly efficient yet still particulate model with the aim to bridge the gap between currently applied methods. The present work focuses on its applicability to confined flows in vessels of diameters up to 100 micrometres. For hematocrit values below 30 percent, a dependence of the apparent viscosity on the vessel diameter in agreement with experimental literature data is found.

  5. Variation in DNA content of blood cells of largemouth bass from contaminated and uncontaminated waters

    SciTech Connect (OSTI)

    Lingenfelser, S.F. [Fish and Wildlife Service, White Marsh, VA (United States); Dallas, C.E. [Univ. of Georgia, Athens, GA (United States). Dept. of Pharmacology and Toxicology; Jagoe, C.H.; Smith, M.H.; Brisbin, I.L. Jr.; Chesser, R.K. [Savannah River Ecology Lab., Aiken, SC (United States)

    1997-10-01T23:59:59.000Z

    Largemouth bass (Micropterus salmoides) were collected from locations with and without documented histories of pollution in Georgia and South Carolina. Whole blood samples were collected from over 3,000 bass and analyzed by flow cytometry to measure changes in cellular DNA content and cell cycle distribution. The coefficient of variation (CV) of the cell cycle phase G{sub 0}G{sub 1} peak was used as a measure of variation in DNA content within an individual. The mean CV varied significantly among locations, and some locations with known chemical or radioactive contaminants had higher CVs. Plotting the frequency distribution of CV values for each site revealed greater skewness and kurtosis in most locations with known contaminants. In each case, a right skewness indicated higher proportions of bass with unusually high CV in these locations. Aneuploid-like patterns were detected in the DNA histograms of five fish, all from locations with histories of contamination. The percentage of cells distributed among phases of the cell cycle (G{sub 0}/G{sub 1}, S, and G{sub 2}M) varied significantly among locations, but there was no apparent relationship to contaminant distribution. Differences in CV and frequency of aneuploids among sites with and without histories of pollution were generally small, but increased variation in DNA content may be associated with contaminant exposure at some locations.

  6. From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood-brain barrier?

    E-Print Network [OSTI]

    Liu, Linan; Eckert, Mark A; Riazifar, Hamidreza; Kang, Dong-Ku; Agalliu, Dritan; Zhao, Weian

    2013-01-01T23:59:59.000Z

    cited. Systemically infused mesenchymal stem cells (MSCs)whether systemically infused MSCs are able to activelywhether systemically infused MSCs can actively migrate

  7. Pitchfork bifurcations in blood-cell shaped dipolar Bose-Einstein condensates

    E-Print Network [OSTI]

    Stefan Rau; Jörg Main; Patrick Köberle; Günter Wunner

    2010-01-08T23:59:59.000Z

    We demonstrate that the method of coupled Gaussian wave packets is a full-fledged alternative to direct numerical solutions of the Gross-Pitaevskii equation of condensates with electromagnetically induced attractive 1/r interaction, or with dipole-dipole interaction. Moreover, Gaussian wave packets are superior in that they are capable of producing both stable and unstable stationary solutions, and thus of giving access to yet unexplored regions of the space of solutions of the Gross-Pitaevskii equation. We apply the method to clarify the theoretical nature of the collapse mechanism of blood-cell shaped dipolar condensates: On the route to collapse the condensate passes through a pitchfork bifurcation, where the ground state itself turns unstable, before it finally vanishes in a tangent bifurcation.

  8. Comparison of blood flow and cell function in ischemic skin flaps

    SciTech Connect (OSTI)

    Bean, D.; Rees, R.S.; O'Leary, J.P.; Lynch, J.B.

    1984-07-01T23:59:59.000Z

    Cellular function and blood flow in acute, steroid-treated, and surgically delayed random skin flaps have been examined. In these studies, the period following flap elevation could be divided into early (0-2 hr), intermediate (4-6 hr), and late (12 hr) periods of ischemia, based on the cutaneous blood flow and cellular function measured by thallium-201 uptake. There was a close correlation between blood flow and cellular function during the early period of ischemia which became worse with time. Blood flow studies demonstrated a significant difference between the early and intermediate periods of ischemia which was abolished by surgical delay. Improvement in cellular function was accomplished by improved blood flow in the surgically delayed flaps, while steroid-treated flaps enhanced cellular metabolism by another mechanism. Cellular function approximated blood flow during the early and immediate period of ischemia. Steroids may augment cellular function without improving blood flow, while surgical delay improves cellular function by improving blood flow.

  9. Red blood cell dynamics: from spontaneous fluctuations to non-linear response Young Zoon Yoon,ab

    E-Print Network [OSTI]

    Cicuta, Pietro

    to its ability to deform and flow through small spaces in the lungs and peripheral circulatory system

  10. Unusual expression of red fluorescence at M phase induced by anti-microtubule agents in HeLa cells expressing the fluorescent ubiquitination-based cell cycle indicator (Fucci)

    SciTech Connect (OSTI)

    Honda-Uezono, Asumi [Section of Oral Radiation Oncology, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan) [Section of Oral Radiation Oncology, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan); Section of Maxillofacial Surgery, Department of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan); Kaida, Atsushi [Section of Oral Radiation Oncology, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan)] [Section of Oral Radiation Oncology, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan); Michi, Yasuyuki; Harada, Kiyoshi [Section of Maxillofacial Surgery, Department of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan)] [Section of Maxillofacial Surgery, Department of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan); Hayashi, Yoshiki; Hayashi, Yoshio [Department of Medicinal Chemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392 (Japan)] [Department of Medicinal Chemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392 (Japan); Miura, Masahiko, E-mail: masa.mdth@tmd.ac.jp [Section of Oral Radiation Oncology, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan)] [Section of Oral Radiation Oncology, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549 (Japan)

    2012-11-16T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Fucci visualizes cell cycle by green and red fluorescence. Black-Right-Pointing-Pointer Plinabulin, induced unusual red fluorescence at M-phase in HeLa-Fucci cells. Black-Right-Pointing-Pointer The unusual pattern was followed by mitotic catastrophe. Black-Right-Pointing-Pointer The unusual pattern may be an early indicator of cell death in HeLa cells. -- Abstract: Plinabulin (NPI-2358) is a novel microtubule-depolymerizing agent. In HeLa cells, plinabulin arrests the cell-cycle at M phase and subsequently induces mitotic catastrophe. To better understand the effects on this compound on the cell-cycle, we used the fluorescent ubiquitination-based cell cycle indicator (Fucci), which normally enables G1 and S/G2/M cells to emit red and green fluorescence, respectively. When HeLa-Fucci cells were treated with 50 nM plinabulin, cells began to fluoresce both green and red in an unusual pattern; most cells exhibited the new pattern after 24 h of treatment. X-irradiation efficiently induced G2 arrest in plinabulin-treated cells and significantly retarded the emergence of the unusual pattern, suggesting that entering M phase is essential for induction of the pattern. By simultaneously visualizing chromosomes with GFP-histone H2B, we established that the pattern emerges after nuclear envelope breakdown but before metaphase. Pedigree assay revealed a significant relationship between the unusual expression and mitotic catastrophe. Nocodazole, KPU-133 (a more potent derivative of plinabulin), and paclitaxel also exerted similar effects. From these data, we conclude that the unusual pattern may be associated with dysregulation of late M phase-specific E3 ligase activity and mitotic catastrophe following treatment with anti-microtubule agents.

  11. Association Between White Blood Cell Count Following Radiation Therapy With Radiation Pneumonitis in Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Tang, Chad; Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wang, Hongmei [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou (China); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang, Yan [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Xu, Ting; Nguyen, Quynh; Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-02-01T23:59:59.000Z

    Purpose: Radiation pneumonitis (RP) is an inflammatory response to radiation therapy (RT). We assessed the association between RP and white blood cell (WBC) count, an established metric of systemic inflammation, after RT for non-small cell lung cancer. Methods and Materials: We retrospectively analyzed 366 patients with non-small cell lung cancer who received ?60 Gy as definitive therapy. The primary endpoint was whether WBC count after RT (defined as 2 weeks through 3 months after RT completion) was associated with grade ?3 or grade ?2 RP. Median lung volume receiving ?20 Gy (V{sub 20}) was 31%, and post-RT WBC counts ranged from 1.7 to 21.2 × 10{sup 3} WBCs/?L. Odds ratios (ORs) associating clinical variables and post-RT WBC counts with RP were calculated via logistic regression. A recursive-partitioning algorithm was used to define optimal post-RT WBC count cut points. Results: Post-RT WBC counts were significantly higher in patients with grade ?3 RP than without (P<.05). Optimal cut points for post-RT WBC count were found to be 7.4 and 8.0 × 10{sup 3}/?L for grade ?3 and ?2 RP, respectively. Univariate analysis revealed significant associations between post-RT WBC count and grade ?3 (n=46, OR=2.6, 95% confidence interval [CI] 1.4?4.9, P=.003) and grade ?2 RP (n=164, OR=2.0, 95% CI 1.2?3.4, P=.01). This association held in a stepwise multivariate regression. Of note, V{sub 20} was found to be significantly associated with grade ?2 RP (OR=2.2, 95% CI 1.2?3.4, P=.01) and trended toward significance for grade ?3 RP (OR=1.9, 95% CI 1.0-3.5, P=.06). Conclusions: Post-RT WBC counts were significantly and independently associated with RP and have potential utility as a diagnostic or predictive marker for this toxicity.

  12. Possible causes of reddish discoloration of urine ("red water") as it involves cattle

    E-Print Network [OSTI]

    Lynd, Frederick Theodore

    1959-01-01T23:59:59.000Z

    produces a severe hssoglobinaaia, uhich is the result of hesolysis of circulating red blood cells by action of tosins or nitro?organisns, the free pageant srceeds the capacity of the reticulo-endothslial systaa ~ nd the henoglobfn is encreted... dilated with a bile snd the walls thickened With fibrous connective tissue. Otaat areas of hepatic tissue in all, stages of necrosis were reticulated with enlarged prominent gupffer cells containing yellow granular pigment. The spleen showed reticulo...

  13. The identification of blood group alleles using antisera produced in non-related populations

    E-Print Network [OSTI]

    Fanguy, Roy Charles, 1929-

    1958-01-01T23:59:59.000Z

    of red blood cells of line 50 birds tested against selected refer? ence reagents. (F^ generation). . ............. 53 IIIo Iso-immunizations made within line 50 to obtain allele-specific A locus reagents iso-immunizations used to produce pure B locus reagents in line 50 b i r d...

  14. Environmental and age effects on methylation changes in human brain and blood cells

    E-Print Network [OSTI]

    Giguzinsky, Orit

    2014-01-01T23:59:59.000Z

    Previous studies have shown that DNA methylation may 1 e associated with disease, aging, the rate of aging and genetics. In this thesis, age is accurately predicted from DNA methylation in brain and blood tissues using two ...

  15. Red Sky with Red Mesa

    ScienceCinema (OSTI)

    None

    2014-06-23T23:59:59.000Z

    The Red Sky/Red Mesa supercomputing platform dramatically reduces the time required to simulate complex fuel models, from 4-6 months to just 4 weeks, allowing researchers to accelerate the pace at which they can address these complex problems. Its speed also reduces the need for laboratory and field testing, allowing for energy reduction far beyond data center walls.

  16. A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells

    E-Print Network [OSTI]

    Du, Pingwu

    We describe ZRL1, a turn-on colorimetric and red fluorescent zinc ion sensor. The Zn2+-promoted ring opening of the rhodamine spirolactam ring in ZRL1 evokes a 220-fold fluorescence turn-on response. In aqueous media, ZRL1 ...

  17. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    E-Print Network [OSTI]

    Wu, Zhigang

    2009-01-01T23:59:59.000Z

    Soft inertial microfluidics for high throughput separation1 Introduction Microfluidics has gained significant advancesof mammalian cells using microfluidics 3,4 , there have been

  18. Decoding the Regulatory Network for Blood Development from Single-Cell Gene Expression Measurements

    E-Print Network [OSTI]

    Moignard, Victoria; Woodhouse, Steven; Haghverdi, Laleh; Lilly, Andrew J.; Tanaka, Yosuke; Wilkinson, Adam C.; Buettner, Florian; Macaulay, Iain C.; Jawaid, Wajid; Diamanti, Evangelia; Nishikawa, Shin-Ichi; Piterman, Nir; Kouskoff, Valerie; Theis, Fabian J.; Fisher, Jasmin; Göttgens, Berthold

    2015-02-09T23:59:59.000Z

    Hbb-bH1 and cell surface markers such as Cdh5 (VE-Cadherin) and Itga2b (CD41), as well as four reference housekeeping genes in all 3,934 cells using microfluidic qRT-PCR technology7 (Supplementary Table 1), which resulted in >150,000 quantitative...

  19. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

    SciTech Connect (OSTI)

    Katika, Madhumohan R. [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands) [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands); Department of Health Risk Analysis and Toxicology, Maastricht University (Netherlands); Netherlands Toxicogenomics Centre (Netherlands)] [Netherlands; Hendriksen, Peter J.M. [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands) [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands); Netherlands Toxicogenomics Centre (Netherlands)] [Netherlands; Shao, Jia [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands) [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands); Department of Health Risk Analysis and Toxicology, Maastricht University (Netherlands); Netherlands Toxicogenomics Centre (Netherlands)] [Netherlands; Loveren, Henk van [Department of Health Risk Analysis and Toxicology, Maastricht University (Netherlands) [Department of Health Risk Analysis and Toxicology, Maastricht University (Netherlands); National Institute for Public Health and the Environment (RIVM), Bilthoven (Netherlands); Netherlands Toxicogenomics Centre (Netherlands)] [Netherlands; Peijnenburg, Ad, E-mail: ad.peijnenburg@wur.nl [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands) [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands); Netherlands Toxicogenomics Centre (Netherlands)] [Netherlands

    2012-10-01T23:59:59.000Z

    Deoxynivalenol (DON) or vomitoxin is a commonly encountered type-B trichothecene mycotoxin, produced by Fusarium species predominantly found in cereals and grains. DON is known to exert toxic effects on the gastrointestinal, reproductive and neuroendocrine systems, and particularly on the immune system. Depending on dose and exposure time, it can either stimulate or suppress immune function. The main objective of this study was to obtain a deeper insight into DON-induced effects on lymphoid cells. For this, we exposed the human T-lymphocyte cell line Jurkat and human peripheral blood mononuclear cells (PBMCs) to various concentrations of DON for various times and examined gene expression changes by DNA microarray analysis. Jurkat cells were exposed to 0.25 and 0.5 ?M DON for 3, 6 and 24 h. Biological interpretation of the microarray data indicated that DON affects various processes in these cells: It upregulates genes involved in ribosome structure and function, RNA/protein synthesis and processing, endoplasmic reticulum (ER) stress, calcium-mediated signaling, mitochondrial function, oxidative stress, the NFAT and NF-?B/TNF-? pathways, T cell activation and apoptosis. The effects of DON on the expression of genes involved in ER stress, NFAT activation and apoptosis were confirmed by qRT-PCR. Other biochemical experiments confirmed that DON activates calcium-dependent proteins such as calcineurin and M-calpain that are known to be involved in T cell activation and apoptosis. Induction of T cell activation was also confirmed by demonstrating that DON activates NFATC1 and induces its translocation from the cytoplasm to the nucleus. For the gene expression profiling of PBMCs, cells were exposed to 2 and 4 ?M DON for 6 and 24 h. Comparison of the Jurkat microarray data with those obtained with PBMCs showed that most of the processes affected by DON in the Jurkat cell line were also affected in the PBMCs. -- Highlights: ? The human T cell line Jurkat and human PBMCs were exposed to DON. ? Whole-genome microarray experiments were performed. ? Microarray data indicates that DON affects ribosome and RNA/protein synthesis. ? DON treatment induces ER stress, calcium mediated signaling, NFAT and NF-?B. ? Exposure to DON induces T cell activation, oxidative stress and apoptosis.

  20. Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease

    E-Print Network [OSTI]

    Boyer, Edmond

    and painful vaso-occlusive crises in children with sickle cell anemia and hemoglobin SC disease. Design with sickle cell anemia, but not in children with hemoglobin SC disease; 2) a higher steady-state red blood with hemoglobin SC disease and boys with sickle cell anemia. Conclusion: Our results indicate for the first time

  1. Multiscale Simulation of Blood Flow in Brain Arteries with an Aneurysm

    SciTech Connect (OSTI)

    Leopold Grinberg; Vitali Morozov; Dmitry A. Fedosov; Joseph Insley; Michael Papka; Kalyan Kumaran; George Karniadakis

    2013-04-24T23:59:59.000Z

    Multi-scale modeling of arterial blood flow can shed light on the interaction between events happening at micro- and meso-scales (i.e., adhesion of red blood cells to the arterial wall, clot formation) and at macro-scales (i.e., change in flow patterns due to the clot). Coupled numerical simulations of such multi-scale flow require state-of-the-art computers and algorithms, along with techniques for multi-scale visualizations. This animation presents results of studies used in the development of a multi-scale visualization methodology. First we use streamlines to show the path the flow is taking as it moves through the system, including the aneurysm. Next we investigate the process of thrombus (blood clot) formation, which may be responsible for the rupture of aneurysms, by concentrating on the platelet blood cells, observing as they aggregate on the wall of the aneurysm

  2. Effects of Exercise and Diet- induced Weight Loss in Overweight/Obese Women on Characterization of Serum/White Blood Cells, microRNAs and Cytokine Gene Transcription

    E-Print Network [OSTI]

    Simbo, Sunday Yamo

    2013-12-11T23:59:59.000Z

    -min circuit resistance-training (3 days/wk) and 30 min walking program on non-workout days. DEXA body composition, fitness, and serum/white blood cells samples were obtained at 0, 4, 8 and 12 wks. The expression of microRNA (21 and 146a...

  3. Method of freezing living cells and tissues with improved subsequent survival

    DOE Patents [OSTI]

    Senkan, Selim M. (Oak Ridge, TN); Hirsch, Gerald P. (Oak Ridge, TN)

    1980-01-01T23:59:59.000Z

    This invention relates to an improved method for freezing red blood cells, ther living cells, or tissues with improved subsequent survival, wherein constant-volume freezing is utilized that results in significantly improved survival compared with constant-pressure freezing; optimization is attainable through the use of different vessel geometries, cooling baths and warming baths, and sample concentrations.

  4. January Blood Drive Announcement | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Red Cross Blood Drive will take place Tuesday, January 27th from 10 a.m.-4 p.m. in CEBAF Center, Room F113. New and repeat donors are encouraged to attend. To schedule an...

  5. Infra-red Microspectral Classification of Cell Populations Under Different Growth Conditions, and Correlations with Genomic Expression Data

    E-Print Network [OSTI]

    -dUTP) for 8735 gene products. #12;The genes may be classified by a clustering algorithm (k-means to Fe metabolism. Figure 2. k-means clustering of ~800 genes showing notable correlated changes from the control mRNA sample for comparison. 2. Spectroscopic Protocols The mammalian cells were

  6. Red River Compact (Texas)

    Broader source: Energy.gov [DOE]

    The Red River Compact Commission administers the Red River Compact to ensure that Texas receives its equitable share of quality water from the Red River and its tributaries as apportioned by the...

  7. Neuron, Vol. 36, 11951210, December 19, 2002, Copyright 2002 by Cell Press Sustained Negative BOLD, Blood Flow and Oxygen

    E-Print Network [OSTI]

    , Blood Flow and Oxygen Consumption Response and Its Coupling to the Positive Response in the Human Brain Several previous human PET (Shulman et al., 1997;Minneapolis, Minnesota 55455 and others) and f

  8. Dietary polyunsaturated fatty acids modify plasma lipids and red blood cell membrane composition but do not induce ?6 desaturase mediated conversions in the domestic feline

    E-Print Network [OSTI]

    McClure, Melena Kathleen

    2009-05-15T23:59:59.000Z

    diets consisted of a commercial diet, supplemented with 8g oil/100g kibble. Oil supplements and subsequent diets were: high-oleic sunflower (H diet) with 82% oleic acid (18:1n-9), Menhaden fish (M diet) with LCn-3FA, and safflower (S diet) with 75% 18:2n...

  9. Dietary polyunsaturated fatty acids modify plasma lipids and red blood cell membrane composition but do not induce ?6 desaturase mediated conversions in the domestic feline 

    E-Print Network [OSTI]

    McClure, Melena Kathleen

    2009-05-15T23:59:59.000Z

    This study explored the effects of dietary unsaturated fatty acids on feline lipid metabolism. It was hypothesized that high dietary linoleic acid (18:2n-6, LA) would enhance conversion to arachidonic acid (20:4n-6), enrichment of dietary long chain...

  10. Relationships between systemic vascular resistance, blood rheology and nitric oxide in children with sickle cell anemia or sickle cell-hemoglobin C disease.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    with sickle cell anemia or sickle cell-hemoglobin C disease. Yann Lamarre1 , Marie-Dominique Hardy-Dessources1 vascular resistance in two main SCD syndromes in children: sickle cell anemia (SCA) and sickle cell, 32]. Sickle cell anemia (SCA) and sickle cell hemoglobin C disease (SCC) are the most frequent forms

  11. A fractal approach to the rheology of concentrated cell suspensions

    E-Print Network [OSTI]

    Andreea Iordan; Alain Duperray; Claude Verdier

    2007-09-23T23:59:59.000Z

    Results on the rheological behavior of novel CHO cell suspensions in a large range of concentrations are reported. The concentration dependent yield stress and elastic plateau modulus are formalized in the context of fractal aggregates under shear, and quite different exponents are found as compared to the case of red blood cell suspensions. This is explained in terms of intrinsic microscopic parameters such as the cell-cell adhesion energy and cell elasticity but also the cell individual dynamic properties, found to correlate well with viscoelastic data at large concentrations (phi>0.5).

  12. Genetic modulation of sickle cell anemia

    SciTech Connect (OSTI)

    Steinberg, M.H. [Univ. of Mississippi School of Medicine, Jackson, MS (United States)

    1995-05-01T23:59:59.000Z

    Sickle cell anemia, a common disorder associated with reduced life span of the red blood cell and vasoocclusive events, is caused by a mutation in the {Beta}-hemoglobin gene. Yet, despite this genetic homogeneity, the phenotype of the disease is heterogeneous. This suggests the modulating influence of associated inherited traits. Some of these may influence the accumulation of fetal hemoglobin, a hemoglobin type that interferes with the polymerization of sickle hemoglobin. Another inherited trait determines the accumulation of {alpha}-globin chains. This review focuses on potential genetic regulators of the phenotype of sickle cell anemia. 125 refs., 6 figs., 3 tabs.

  13. Circadian rhythms and glucocorticoids in a cell culture model of bipolar disorder

    E-Print Network [OSTI]

    Darvish, Ryan Mitchell

    2011-01-01T23:59:59.000Z

    in children with acute lymphoblastic leukemia. Blood 109,genes in acute lymphoblastic leukemia cells. (2007). Blood

  14. Red Harvester Ants

    E-Print Network [OSTI]

    Drees, Bastiaan M.

    2006-04-24T23:59:59.000Z

    Red harvester ants are one of the more noticeable and larger ants in open areas in Texas. However, their populations are declining and this has affected an animal that preys upon the ants--the threatened Texas horned lizard....

  15. Monoclonal antibodies to human hemoglobin S and cell lines for the production thereof

    DOE Patents [OSTI]

    Jensen, R.H.; Vanderlaan, M.; Bigbee, W.L.; Stanker, L.H.; Branscomb, E.W.; Grabske, R.J.

    1984-11-29T23:59:59.000Z

    The present invention provides monoclonal antibodies specific to and distinguishing between hemoglobin S and hemoglobin A and methods for their production and use. These antibodies are capable of distinguishing between two hemoglobin types which differ from each other by only a single amino acid residue. The antibodies produced according to the present method are useful as immunofluorescent markers to enumerate circulating red blood cells which have the property of altered expression of the hemoglobin gene due to somatic mutation in stem cells. Such a measurement is contemplated as an assay for in vivo cellular somatic mutations in humans. Since the monoclonal antibodies produced in accordance with the instant invention exhibit a high degree of specificity to and greater affinity for hemoglobin S, they are suitable for labeling human red blood cells for flow cytometric detection of hemoglobin genotype. 4 figs.

  16. Monoclonal antibodies to human hemoglobin S and cell lines for the production thereof

    DOE Patents [OSTI]

    Jensen, Ronald H. (Livermore, CA); Vanderlaan, Martin (San Ramon, CA); Bigbee, William L. (Livermore, CA); Stanker, Larry H. (Livermore, CA); Branscomb, Elbert W. (Walnut Creek, CA); Grabske, Robert J. (Berkeley, CA)

    1988-01-01T23:59:59.000Z

    The present invention provides monoclonal antibodies specific to and distinguish between hemoglobin S and hemoglobin A and methods for their production and use. These antibodies are capable of distinguishing between two hemoglobin types which differ from each other by only a single amino acid residue. The antibodies produced according to the present method are useful as immunofluorescent markers to enumerate circulating red blood cells which have the property of altered expression of the hemoglobin gene due to somatic mutation in stem cells. Such a measurement is contemplated as an assay for in vivo cellular somatic mutations in humans. Since the monoclonal antibodies produced in accordance with the instant invention exhibit a high degree of specificity to and greater affinity for hemoglobin S, they are suitable for labeling human red blood cells for flow cytometric detection of hemoglobin genotype.

  17. Mesoporous silica nanoparticles as smart and safe devices for regulating blood biomolecule levels

    SciTech Connect (OSTI)

    Zhao, Yan

    2011-05-15T23:59:59.000Z

    Stimuli-responsive end-capped MSN materials are promising drug carriers that securely deliver a large payload of drug molecules without degradation or premature release. A general review of the recent progress in this field is presented, including a summary of a series of hard and soft caps for drug encapsulation and a variety of internal and external stimuli for controlled release of different therapeutics, a discussion of the biocompatibility of MSN both in vitro and in vivo, and a description of the sophisticated stimuli-responsive systems with novel capping agents and controlled release mechanism. The unique internal and external surfaces of MSN were utilized for the development of a glucose-responsive double delivery system end-capped with insulin. This unique system consists of functionalized MSNs capable of releasing insulin when the concentration of sugar in blood exceeds healthy levels. The insulin-free nanoparticles are then up taken by pancreatic cells, and release inside of them another biomolecule that stimulates the production of more insulin. The in vivo application of this system for the treatment of diabetes requires further understanding on the biological behaviors of these nanoparticles in blood vessels. The research presented in this dissertation demonstrated the size and surface effects on the interaction of MSNs with red blood cell membranes, and discovered how the surface of the nanoparticles can be modified to improve their compatibility with red blood cells and avoid their dangerous side effects. In order to optimize the properties of MSN for applying them as efficient intracellular drug carriers it is necessary to understand the factors that can regulate their internalization into and exocytosis out of the cells. The correlation between the particle morphology and aggregation of MSNs to the effectiveness of cellular uptake is discussed and compared with different cell lines. The differences in the degree of exocytosis of MSNs between healthy and cancer cells is reported and found to be responsible for the asymmetric transfer of the particles between both cell types. The fundamental studies on the hemocompatibility, endo- and exocytosis of MSN along with its ability to sequentially release multiple therapeutics in response to different stimuli, allow us to propose MSN as an intravascular vehicle with a great potential for various biomedical applications.

  18. Development and Validation of a Prognostic Model Using Blood Biomarker Information for Prediction of Survival of Non-Small-Cell Lung Cancer Patients Treated With Combined Chemotherapy and Radiation or Radiotherapy Alone (NCT00181519, NCT00573040, and NCT00572325)

    SciTech Connect (OSTI)

    Dehing-Oberije, Cary, E-mail: cary.dehing@maastro.nl [Department of Radiation Oncology (MAASTRO Clinic), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht (Netherlands); Aerts, Hugo [Department of Radiation Oncology (MAASTRO Clinic), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht (Netherlands); Yu Shipeng [Siemens Medical Solutions, Malvern, PA (United States); De Ruysscher, Dirk [Department of Radiation Oncology (MAASTRO Clinic), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht (Netherlands); Menheere, Paul [Department of Clinical Chemistry, Maastricht University Medical Centre, Maastricht (Netherlands); Hilvo, Mika [Institute of Medical Technology, University of Tampere, Tampere (Finland); VTT Technical Research Centre of Finland, Espoo (Finland); Weide, Hiska van der [Department of Radiation Oncology (MAASTRO Clinic), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht (Netherlands); Rao, Bharat [Siemens Medical Solutions, Malvern, PA (United States); Lambin, Philippe [Department of Radiation Oncology (MAASTRO Clinic), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht (Netherlands)

    2011-10-01T23:59:59.000Z

    Purpose: Currently, prediction of survival for non-small-cell lung cancer patients treated with (chemo)radiotherapy is mainly based on clinical factors. The hypothesis of this prospective study was that blood biomarkers related to hypoxia, inflammation, and tumor load would have an added prognostic value for predicting survival. Methods and Materials: Clinical data and blood samples were collected prospectively (NCT00181519, NCT00573040, and NCT00572325) from 106 inoperable non-small-cell lung cancer patients (Stages I-IIIB), treated with curative intent with radiotherapy alone or combined with chemotherapy. Blood biomarkers, including lactate dehydrogenase, C-reactive protein, osteopontin, carbonic anhydrase IX, interleukin (IL) 6, IL-8, carcinoembryonic antigen (CEA), and cytokeratin fragment 21-1, were measured. A multivariate model, built on a large patient population (N = 322) and externally validated, was used as a baseline model. An extended model was created by selecting additional biomarkers. The model's performance was expressed as the area under the curve (AUC) of the receiver operating characteristic and assessed by use of leave-one-out cross validation as well as a validation cohort (n = 52). Results: The baseline model consisted of gender, World Health Organization performance status, forced expiratory volume, number of positive lymph node stations, and gross tumor volume and yielded an AUC of 0.72. The extended model included two additional blood biomarkers (CEA and IL-6) and resulted in a leave-one-out AUC of 0.81. The performance of the extended model was significantly better than the clinical model (p = 0.004). The AUC on the validation cohort was 0.66 and 0.76, respectively. Conclusions: The performance of the prognostic model for survival improved markedly by adding two blood biomarkers: CEA and IL-6.

  19. Red Raider Orientation COLLEGE DISMISSAL

    E-Print Network [OSTI]

    Rock, Chris

    Communications, etc.) #12;#12;RED RAIDER ORIENTATION Business Administration Accounting Energy Commerce Finance General Business International Business Management Management Information Systems Marketing Visual &Performing Arts Art Dance VPA General Studies Music Theatre Arts #12;RED RAIDER ORIENTATION

  20. Red Rice Research and Control. 

    E-Print Network [OSTI]

    Baker, John B.; Baldwin, Ford L.; Bourgeois, W.J.; Cox, Clodis H.; Craigmiles, Julian P.; Dishman, William D.; Eastin, E. Ford; Helpert, Charles W.; Hill, Lewis C.; Huey, Bobby A.; Klosterboer, Arlen D.; Sonnier, Earl A.

    1980-01-01T23:59:59.000Z

    ...................................... 10 E. A. Sonnier RED RICE CONTROL IN ALTERNATE CROPS ................................ 16 F. L. Baldwin ..# RED RICE CONTROL ..................................................lg B. A. Huey and F. L. Baldwin RED RICE HERBICIDE SCREENING TESTS...-to-date information available on a subject of major concern to rice producers. E. F. Eastin, editor The Texas Agricultural Experiment Station Beaumont INTRODUCTION J. P. Craigmiles The purpose of t h i s red r i c e symposium i s straightforward and simple...

  1. Understanding Blood Pressure

    E-Print Network [OSTI]

    Understanding Blood Pressure · Monitorathomewithadigitalmonitor. · Useleftarmwithcorrectsizecuff. · Avoidcaffeine,alcohol,andtobacco. Steps to Follow FOR AN ACCURATE MEASUREMENT Blood pressure is the measurement of the force of blood on the walls of the arteries. Bottom number = Diastolic (force between heart beats) Top

  2. The Centre for Blood Research Wolfgang R. Mayr Prof. Dr. Dr. h.c.

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Wolfgang R. Mayr Prof. Dr. Dr. h.c. Department for Blood Group Affairs, Canadian Blood Services A chimera is an organism consisting of two (or more) zygotes. Two types (transplacental passage of blood cells from the mother to the child and vice versa) or permanent (blood chimerism

  3. Pokeberries Provide Boost for Solar Cells

    Broader source: Energy.gov [DOE]

    Red dye from the pokeberry weed makes their low-cost, fiber-based solar cells even more energy efficient.

  4. Chili with Red Beans Ingredients

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    tender, about three minutes. 4. Open kidney beans and pour into a colander. Rinse under cool waterChili with Red Beans Ingredients: 1/2 pound ground beef, extra lean 1 medium onion, chopped 4 cups red kidney beans, soaked overnight or 2 cans, rinsed 3 cups tomatoes, chopped, or 28 ounces, canned 1

  5. Reprogramming peripheral blood mononuclear cells using an efficient feeder-free, non-integration method to generate iPS cells and the effect of immunophenotype and epigenetic state on HSPC fate 

    E-Print Network [OSTI]

    Liu, Jing

    2014-11-28T23:59:59.000Z

    Background and objectives In 2006 Shinya Yamanaka successfully reprogrammed mouse fibroblasts back to an embryonic stem cell-like state (called induced pluripotent cells, iPS cells) using retrovirus to introduce four ...

  6. This section of Journal of Materials Research is reserved for papers that are reviews of literature in a given area. Mechanical response of human red blood cells in health and

    E-Print Network [OSTI]

    Suresh, Subra

    and computational biology, bio- physics, biochemistry, biomedical engineering, medi- cine, and genomics. These developments, along with substantial progress in bioim- aging and genomics, have collectively provided new ca

  7. LONG-CHAIN POLYUNSATURATED FATTY ACID INTAKE AND ITS RELATIONSHIP TO RED BLOOD CELL AND SERUM LONG-CHAIN POLYUNSATURATED FATTY ACIDS IN WOMEN AT HIGH RISK FOR BREAST CANCER

    E-Print Network [OSTI]

    Harvey, Katherine

    2010-04-27T23:59:59.000Z

    questionnaire (DHQ). The mean age of the subjects was 47 ± 9.9 years, and the mean body mass index (BMI) was 25 ± 4.4. The mean 5-year Gail risk was 2.7 ± 2.2%. Twenty-two (48%) of the subjects were premenopausal and 24 (52%) were postmenopausal. Fifteen (33...

  8. Jamaican red clay tobacco pipes

    E-Print Network [OSTI]

    Heidtke, Kenan Paul

    1992-01-01T23:59:59.000Z

    JAMAICAN RED CLAY TOBACCO PIPES A Thesis by KENAN PAUL HEIDTKE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF ARTS December 1992 Major Subject...: Anthropology JAMAICAN RED CLAY TOBACCO PIPES A Thesis by KENAN PAUL HEIDTKE Approved as to style and content by: Dorm L. Hamilton (Chair of Committee) Frederick H. van Doorninck, J (Member) enry C. Schmidt (Member) Vaughn M. Bryant (Head...

  9. Computational Biorheology of Human Blood Flow in Health and Disease DMITRY A. FEDOSOV,1

    E-Print Network [OSTI]

    Dao, Ming

    with results obtained using this computational framework for blood flow in malaria and sickle cell anemia in the later stages of the intra-cell parasite development.36 Sickle cell anemia is another blood disorder. Keywords--Hematologic disorders, Dissipative particle dynamics, Coarse-graining, Malaria, Sickle cell

  10. Red Means Go Information Technology

    E-Print Network [OSTI]

    Projects ·Budget Issues #12;Red Means Go Strategic Operations Plan (SOP) ·Articulate the OIT vision, planning, and other business functions · Scope: Project will impact university data users (executive Means Go Directions and Opportunities for OIT ·Three Phase Plan for IT Improvement ·Develop Strategic

  11. EA-1692: Red River Environmental Products, LLC Activated Carbon...

    Office of Environmental Management (EM)

    2: Red River Environmental Products, LLC Activated Carbon Manufacturing Facility, Red River Parish, LA EA-1692: Red River Environmental Products, LLC Activated Carbon Manufacturing...

  12. Microsoft Word - Red Detector Tests _3_.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Red Detector Tests May 5 ed -2006 1. Black Body @ 900F, Comparison between red and blue detectors: Table 1: Detector's signal with and without filters -BB at 900F Filter(micron)...

  13. In Vivo Blood Characterization from Bioimpedance Spectroscopy of Blood

    E-Print Network [OSTI]

    Adler, Andy

    In Vivo Blood Characterization from Bioimpedance Spectroscopy of Blood Pooling Tao Dai Department@sce.carleton.ca Abstract Characterization of blood impedance properties is important to estimate clinical diagnos- tic in the measurement field, rather than the blood individually. This paper describes a novel in vivo measurement

  14. Variation in sister chromatid exchange frequencies between human and pig whole blood, plasma leukocyte, and mononuclear leukocyte cultures

    SciTech Connect (OSTI)

    Larramendy, M.L.; Reigosa, M.A.

    1986-01-01T23:59:59.000Z

    Sister chromatid exchange (SCE) induction by ultraviolet (UV) light was studied in both human and pig whole blood cultures (WBC) and plasma leukocyte cultures (PLC). No variation in SCE frequency was observed between pig WBC and PLC in control as well as in treated cells. Conversely, SCE frequencies of human PLC were consistently higher than those of WBC in control and UV-exposed cells. Thus, red blood cells (RBCs) do not influence the sensitivity of lymphocytes to UV LIGHT exposure, and there must be some different culture condition(s) in the inducation of SCEs between human WBC and PLC but not in swine lymphocyte cultures. Since the BrdUrd/lymphocyte ratio of WBC was halved in PLC, the effect of BrdUrd concentration in inducing the SCE baseline frequency of PLC may be ruled out. Neither the cell separation technique nor polymorphonuclear leukocytes had a significant role in the elevated SCE frequency of human PLC or MLC. Experiments where human RBCs were titrated into human PLC showed that the induction of an elevated SCE frequency of PLC was suppressed in a dose-dependent manner by the presence of RBCs in the culture medium. Since the incorporation of pig or human RBCs into human PLC as well as into MLC reduced the SCE frequency to that of WBC, a common component and/or function existing in these cells is suggested. Analysis of different RBC components showed that RBCs, specifically RBC ghosts, release a diffusible but not dialyzable corrective factor into culture medium that is able to reduce the SCE frequencies of PLC.

  15. Red Rice Research and Control.

    E-Print Network [OSTI]

    Baker, John B.; Baldwin, Ford L.; Bourgeois, W.J.; Cox, Clodis H.; Craigmiles, Julian P.; Dishman, William D.; Eastin, E. Ford; Helpert, Charles W.; Hill, Lewis C.; Huey, Bobby A.; Klosterboer, Arlen D.; Sonnier, Earl A.

    1980-01-01T23:59:59.000Z

    -to-date information available on a subject of major concern to rice producers. E. F. Eastin, editor The Texas Agricultural Experiment Station Beaumont INTRODUCTION J. P. Craigmiles The purpose of t h i s red r i c e symposium i s straightforward and simple... - t o discuss the l a t e s t f indings and procedures f o r con t ro l l ing red r i c e . In accom- pl ishing t h i s we want two-way communication s o t h a t all present w i l l become current on t h i s most noxious weed of r i c e...

  16. Blood Pressure Medicine: Special Instructions

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Blood Pressure Medicine: Special Instructions: U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute · What is my blood pressure reading in numbers? · What is my goal blood pressure? · Is there a healthy eating plan that I should follow to help

  17. BLOOD SAMPLING SYSTEM TROUBLESHOOTING TIPS

    E-Print Network [OSTI]

    Kay, Mark A.

    SAFESET TM BLOOD SAMPLING SYSTEM SAFESETTM TROUBLESHOOTING TIPS TO PREVENT BLOOD BACKING UP IN LINE that all air bubbles have been eliminated when priming o Invert and tap blood sampling ports to remove air volume o Reinfuse the patient's blood slowly, no faster than 1mL per second, by pressing the plunger back

  18. Chemical Engineering Education232 lood is a complex fluid composed of cells and other

    E-Print Network [OSTI]

    Simmons, Craig A.

    of blood are altered under certain pathological conditions, such as sickle cell anemia where abnormalities

  19. Red Mesa | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-f < RAPID‎ | Roadmap Jump to:bJumpRed Bank, New Jersey:Mesa Jump to:

  20. Broadband Dielectric Spectroscopy on Human Blood

    E-Print Network [OSTI]

    M. Wolf; R. Gulich; P. Lunkenheimer; A. Loidl

    2011-05-25T23:59:59.000Z

    Dielectric spectra of human blood reveal a rich variety of dynamic processes. Achieving a better characterization and understanding of these processes not only is of academic interest but also of high relevance for medical applications as, e.g., the determination of absorption rates of electromagnetic radiation by the human body. The dielectric properties of human blood are studied using broadband dielectric spectroscopy, systematically investigating the dependence on temperature and hematocrit value. By covering a frequency range from 1 Hz to 40 GHz, information on all the typical dispersion regions of biological matter is obtained. We find no evidence for a low-frequency relaxation (alpha-relaxation) caused, e.g., by counterion diffusion effects as reported for some types of biological matter. The analysis of a strong Maxwell-Wagner relaxation arising from the polarization of the cell membranes in the 1-100 MHz region (beta-relaxation) allows for the test of model predictions and the determination of various intrinsic cell properties. In the microwave region beyond 1 GHz, the reorientational motion of water molecules in the blood plasma leads to another relaxation feature (gamma-relaxation). Between beta- and gamma-relaxation, significant dispersion is observed, which, however, can be explained by a superposition of these relaxation processes and is not due to an additional delta-relaxation often found in biological matter. Our measurements provide dielectric data on human blood of so far unsurpassed precision for a broad parameter range. All data are provided in electronic form to serve as basis for the calculation of the absorption rate of electromagnetic radiation and other medical purposes. Moreover, by investigating an exceptionally broad frequency range, valuable new information on the dynamic processes in blood is obtained.

  1. Blood Conservation in Cardiac Surgery 

    E-Print Network [OSTI]

    Slight, Robert

    2008-01-01T23:59:59.000Z

    Cardiac surgery is traditionally a heavy user of blood and blood products. Until recently, the benefits of transfusion have been largely assumed and the risks relatively ignored. This has prompted us to examine new ways ...

  2. MyRED Mobiles Student Views

    E-Print Network [OSTI]

    Farritor, Shane

    tap on Shopping Cart, then select term. Tap on Class Search to find courses to place in your shoppingMyRED Mobiles Student Views Mar 2014 Page 1 Login/Sign-in Enter your MyRED /TrueYou credentials. Tap on any Term bar to view a schedule for the selected term. Home Screen/Main Menu Class Schedule

  3. BLOOD CHARACTERIZATION FROM PULSATILE BIOIMPEDANCE SPECTROSCOPY

    E-Print Network [OSTI]

    Adler, Andy

    BLOOD CHARACTERIZATION FROM PULSATILE BIOIMPEDANCE SPECTROSCOPY Tao Dai Systems and Computer of blood using three measuring frequencies. Characterization of blood bioimpedance properties; however, Current bioimpedance spectroscopy measurements of blood are ei- ther in vitro[6

  4. Combinatorial Screening Of Inorganic And Organometallic Materials

    DOE Patents [OSTI]

    Li, Yi (Miami, FL), Li, Jing (Miami, FL), Britton, Ted W. (Sunrise, FL)

    2002-06-25T23:59:59.000Z

    A method for differentiating and enumerating nucleated red blood cells in a blood sample is described. The method includes the steps of lysing red blood cells of a blood sample with a lytic reagent, measuring nucleated blood cells by DC impedance measurement in a non-focused flow aperture, differentiating nucleated red blood cells from other cell types, and reporting nucleated red blood cells in the blood sample. The method further includes subtracting nucleated red blood cells and other interference materials from the count of remaining blood cells, and reporting a corrected white blood cell count of the blood sample. Additionally, the method further includes measuring spectrophotometric absorbance of the sample mixture at a predetermined wavelength of a hemoglobin chromogen formed upon lysing the blood sample, and reporting hemoglobin concentration of the blood sample.

  5. U-200: Red Hat Directory Server Information Disclosure Security...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    0: Red Hat Directory Server Information Disclosure Security Issue and Vulnerability U-200: Red Hat Directory Server Information Disclosure Security Issue and Vulnerability June 27,...

  6. T-678: Red Hat Enterprise Virtualization Hypervisor VLAN Packet...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    8: Red Hat Enterprise Virtualization Hypervisor VLAN Packet Processing Flaw Lets Remote Users Deny Service T-678: Red Hat Enterprise Virtualization Hypervisor VLAN Packet...

  7. The RenalCountercurrentMechanism Ttre function of the kidney is to regulate the composition of the blood

    E-Print Network [OSTI]

    Olufsen, Mette Sofie

    of the blood plasrna.The plasma is the part of the blood that rernains when the cells been removed. We shall consider only the regulation of the Nai cblood plasma, but the rea.dershoulJ keep in mind an organism with a variable diet, the kidney can achieve a constalt I ' , concentration in blood plasma only

  8. On Bitcoin and Red Balloons

    E-Print Network [OSTI]

    Babaioff, Moshe; Oren, Sigal; Zohar, Aviv

    2011-01-01T23:59:59.000Z

    We study scenarios in which the goal is to ensure that some information will propagate through a large network of nodes. In these scenarios all nodes that are aware of the information compete for the same prize, and thus have an incentive not to propagate information. One example for such a scenario is the 2009 DARPA Network Challenge (finding red balloons). We give special attention to a second domain, Bitcoin, a decentralized electronic currency system. Bitcoin, which has been getting a large amount of public attention over the last year, represents a radical new approach to monetary systems which has appeared in policy discussions and in the popular press. Its cryptographic fundamentals have largely held up even as its usage has become increasingly widespread. We find, however, that it exhibits a fundamental problem of a different nature, based on how its incentives are structured. We propose a modification to the protocol that can fix this problem. Bitcoin relies on a peer-to-peer network to track transac...

  9. Red Fluorescent Protein pH Biosensor to Detect Concentrative Nucleoside Transport*S

    E-Print Network [OSTI]

    Campbell, Robert E.

    Red Fluorescent Protein pH Biosensor to Detect Concentrative Nucleoside Transport*S Received concentrative nucleoside transporter, hCNT3, medi- ates Na /nucleoside and H /nucleoside co-transport. We describe a new approach to monitor H /uridine co-transport in cultured mammalian cells, using a p

  10. Right Turn on Red! | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    benefits for the country, helping us all save money by saving energy. Prior to the 1970's, some states already allowed drivers to turn right on a red light, but many others -...

  11. Redding Electric- Earth Advantage Rebate Program

    Broader source: Energy.gov [DOE]

    The Earth Advantage Rebate Program was designed to offer rebates to residential and business customers of Redding Electric Utility (REU) for solar PV, solar thermal, and geothermal heat pump...

  12. THE TEMPERATURES OF RED SUPERGIANTS

    SciTech Connect (OSTI)

    Davies, Ben [Astrophysics Research Institute, Liverpool John Moores University, Egerton Wharf, Birkenhead CH41 1LD (United Kingdom)] [Astrophysics Research Institute, Liverpool John Moores University, Egerton Wharf, Birkenhead CH41 1LD (United Kingdom); Kudritzki, Rolf-Peter; Gazak, Zach [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)] [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Plez, Bertrand [Laboratoire Univers et Particules de Montpellier, Universite Montpellier 2, CNRS, F-34095 Montpellier (France)] [Laboratoire Univers et Particules de Montpellier, Universite Montpellier 2, CNRS, F-34095 Montpellier (France); Trager, Scott [Kapteyn Institute, University of Groningen, P.O. Box 800, 9700-AV Groningen (Netherlands)] [Kapteyn Institute, University of Groningen, P.O. Box 800, 9700-AV Groningen (Netherlands); Lancon, Ariane [Observatoire Astronomique and CNRS UMR 7550, Universite de Strasbourg, F-67000 Strasbourg (France)] [Observatoire Astronomique and CNRS UMR 7550, Universite de Strasbourg, F-67000 Strasbourg (France); Bergemann, Maria [Max-Planck-Institute for Astrophysics, Karl-Schwarzschild-Str. 1, D-85741 Garching (Germany)] [Max-Planck-Institute for Astrophysics, Karl-Schwarzschild-Str. 1, D-85741 Garching (Germany); Evans, Chris [UK Astronomy Technology Centre, Royal Observatory Edinburgh, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom)] [UK Astronomy Technology Centre, Royal Observatory Edinburgh, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Chiavassa, Andrea [CNRS Laboratoire Lagrange, Universite de Nice Sophia-Antipolis, Observatoire de la Cote d'Azur, BP 4229, F-06304 Nice Cedex 4 (France)] [CNRS Laboratoire Lagrange, Universite de Nice Sophia-Antipolis, Observatoire de la Cote d'Azur, BP 4229, F-06304 Nice Cedex 4 (France)

    2013-04-10T23:59:59.000Z

    We present a re-appraisal of the temperatures of red supergiants (RSGs) using their optical and near-infrared spectral energy distributions (SEDs). We have obtained data of a sample of RSGs in the Magellanic Clouds using VLT+XSHOOTER, and we fit MARCS model atmospheres to different regions of the spectra, deriving effective temperatures for each star from (1) the TiO bands, (2) line-free continuum regions of the SEDs, and (3) the integrated fluxes. We show that the temperatures derived from fits to the TiO bands are systematically lower than the other two methods by several hundred kelvin. The TiO fits also dramatically overpredict the flux in the near-IR, and imply extinctions which are anomalously low compared to neighboring stars. In contrast, the SED temperatures provide good fits to the fluxes at all wavelengths other than the TiO bands, are in agreement with the temperatures from the flux integration method, and imply extinctions consistent with nearby stars. After considering a number of ways to reconcile this discrepancy, we conclude that three-dimensional effects (i.e., granulation) are the most likely cause, as they affect the temperature structure in the upper layers where the TiO lines form. The continuum, however, which forms at much deeper layers, is apparently more robust to such effects. We therefore conclude that RSG temperatures are much warmer than previously thought. We discuss the implications of this result for stellar evolution and supernova progenitors, and provide relations to determine the bolometric luminosities of RSGs from single-band photometry.

  13. POPULATION BIOLOGY OF RED ABAWNES, HALIOTIS RUFESCENS, IN SOUTHERN CALIFORNIA AND MANAGEMENT OF THE RED AND

    E-Print Network [OSTI]

    ABSTRACT Population dynamics of red abalones. Hal·wti.s rufeSC611,8 Swainson. were studied at Johnsons Lee

  14. MFR PAPER 1229 Red Snappers of the Carolina Coast

    E-Print Network [OSTI]

    Coast to the Campeche Banks. A closely related species, the Caribbean red snapper, Lutjanus pur- pureus

  15. Improved ``Optical Highlighter'' Probes Derived from Discosoma Red Fluorescent Protein

    E-Print Network [OSTI]

    Marchant, Jonathan

    , Minneapolis, Minnesota ABSTRACT The tetrameric red fluorescent protein, DsRed, undergoes a rapid red to green-emitting species of DsRed and an enhancement of emission from the ``immature'' green species, likely caused by dequenching of fluorescence resonance energy transfer occurring within the protein tetramer. Here, we have

  16. Newtonian gravity, red shift, confinement, asymptotic freedom and quarks oscillations

    E-Print Network [OSTI]

    G. Quznetsov

    2008-10-18T23:59:59.000Z

    Quarks oscillations give the Newtonian gravity law, the red shift, the confinement and the asymptotic freedom.

  17. Red Cross honors LLNL as biggest blood donor west of Mississippi | National

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA Approved: 5-13-14 FEDERALAmerica TreatyWastewantsRequests||Nuclear Security

  18. May 12 EXPO Event Schedule 8:00-11:00 Red Cross Blood Drive Bloodmobile

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHighand Retrievals from a NewCuneo Matthew1, 2012 1:00 - 2:00 p.m. ToMay 12

  19. Consanguine Calculations Input File: blood.in

    E-Print Network [OSTI]

    California at Berkeley, University of

    1 of 20 Problem A+ Consanguine Calculations Input File: blood.in Every person's blood has 2 markers in a particular ABO blood type for that person. Combination ABO Blood Type AA A AB AB AO A BB B BO B OO O Likewise, every person has two alleles for the blood Rh factor, represented by the characters + and -. Someone who

  20. The development of an automated system for electrical characterization of cells using a novel force balance method

    E-Print Network [OSTI]

    Su, Hao-Wei

    2012-01-01T23:59:59.000Z

    Dielectrophoresis (DEP), a cell separation technique based on the dielectric properties, has significantly advanced biomedical research in diverse applications ranging from blood stem cells purification to cancer cells ...

  1. Development and examination of blood substitute media for application in simulated blood circulation

    E-Print Network [OSTI]

    Berlin,Technische Universität

    IAbstract Development and examination of blood substitute media for application in simulated blood and evaluates the applicability of potentially possible blood substitutes and their influence parameters behaviour of bio-degradable polymers. Furthermore, information about used blood substitutes, influencing

  2. The Centre for Blood Research Dr. Peter Schubert

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Dr. Peter Schubert Clinical Associate Professor Pathology & Laboratory Medicine Research Associate, Canadian Blood Services "Transfusion science of blood safety" As a blood banking organization, Canadian Blood Services is committed to blood component quality and safety

  3. Conserving Scotland's Red Squirrels Scotland supports an estimated 75% of the UK red squirrel population. Although one

    E-Print Network [OSTI]

    to save the red squirrel for future generations. We will continue to be involved with wider partnerships is co-ordinated nationwide. Public involvement is crucial to saving red squirrels in Scotland and we are delighted to support this through projects such as Saving Scotland's Red Squirrels, Red Squirrels

  4. 7X performance results - final report : ASCI Red vs Red Storm.

    SciTech Connect (OSTI)

    Dinge, Dennis C. (Cray Inc., Albuquerque, NM); Davis, Michael E. (Cray Inc., Albuquerque, NM); Haskell, Karen H.; Ballance, Robert A.; Gardiner, Thomas Anthony; Stevenson, Joel O.; Noe, John P.

    2011-04-01T23:59:59.000Z

    The goal of the 7X performance testing was to assure Sandia National Laboratories, Cray Inc., and the Department of Energy that Red Storm would achieve its performance requirements which were defined as a comparison between ASCI Red and Red Storm. Our approach was to identify one or more problems for each application in the 7X suite, run those problems at multiple processor sizes in the capability computing range, and compare the results between ASCI Red and Red Storm. The first part of this report describes the two computer systems, the applications in the 7X suite, the test problems, and the results of the performance tests on ASCI Red and Red Storm. During the course of the testing on Red Storm, we had the opportunity to run the test problems in both single-core mode and dual-core mode and the second part of this report describes those results. Finally, we reflect on lessons learned in undertaking a major head-to-head benchmark comparison.

  5. CUTTING SOLAR RED TAPECUTTING SOLAR RED TAPE Evergreen State Solar PartnershipEvergreen State Solar Partnership

    E-Print Network [OSTI]

    CUTTING SOLAR RED TAPECUTTING SOLAR RED TAPE Evergreen State Solar PartnershipEvergreen State Solar Partnership Rooftop Solar Challenge 1 Sunshot #12;WASHINGTON PV CONTEXTWASHINGTON PV CONTEXT 285 cities, 39 Installations happen where process is easier #12;EVERGREEN STATE SOLAR PARTNERSHIP Commerce NWSEEDEdmonds

  6. Red mud characterization using nuclear analytical techniques

    SciTech Connect (OSTI)

    Obhodas, J.; Sudac, D.; Matjacic, L. [Dept. of Experimental Physics, Inst. Ruder Boskovic, Zagreb (Croatia); Valkovic, V. [A.C.T.d.o.o., Prilesje 4, Zagreb (Croatia)

    2011-07-01T23:59:59.000Z

    Red mud is a toxic waste left as a byproduct in aluminum production Bayer process. Since it contains significant concentrations of other chemical elements interesting for industry, including REE, it is also potential secondary ore source. Recent events in some countries have shown that red mud presents a serious environmental hazard if not properly stored. The subject of our study is the red mud from an ex-aluminum plant in Obrovac, Croatia, left from processing of bauxite mined during late 70's and early 80's at the eastern Adriatic coast and since than stored in open concrete basins for more than 30 years. We have used energy dispersive x-ray fluorescence analysis (both tube and radioactive source excitation), fast neutron activation analysis and passive gamma spectrometry to identify a number of elements present in the red mud, their concentration levels and radioactivity in the red mud. The high concentrations of Al, Si, Ca, Ti and Fe have been measured. Chemical elements Sc, Cr, Mn, Co, Ni, Cu, Zn, Ga, As, Se, Br, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Pb, Th and U were found in lower concentrations. No significant levels of radioactivity have been measured. (authors)

  7. Simple filter microchip for rapid separation of plasma and viruses from whole blood

    E-Print Network [OSTI]

    Demirci, Utkan

    Sample preparation is a significant challenge for detection and sensing technologies, since the presence of blood cells can interfere with the accuracy and reliability of virus detection at the nanoscale for point-of-care ...

  8. Blood Banking in Living Droplets

    E-Print Network [OSTI]

    Samot, Josh

    Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification has shown advantages over traditional ...

  9. Microfluidic Devices for Blood Fractionation

    E-Print Network [OSTI]

    Hou, Han Wei

    Blood, a complex biological fluid, comprises 45% cellular components suspended in protein rich plasma. These different hematologic components perform distinct functions in vivo and thus the ability to efficiently fractionate ...

  10. Red River Biodiesel Ltd | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-f < RAPID‎ | Roadmap Jump to:bJumpRed Bank, New Jersey:Mesa Jump to:Red

  11. Redding, Connecticut: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt Ltd Jump to: navigation, searchRay County,OpenCounty, Texas:RedRedbird,Redding,

  12. Cell-intrinsic Transforming Growth Factor-[beta] signaling mediates virus-specific CD8? T cell deletion and lymphocytic choriomeningitis virus persistence in vivo

    E-Print Network [OSTI]

    Tinoco, Roberto

    2010-01-01T23:59:59.000Z

    Persistent numbers of tetramer+ CD8(+) T cells, but loss ofepitopes were monitored by tetramer staining throughout theof peripheral blood tetramer-positive CD8 + T cells were

  13. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

    SciTech Connect (OSTI)

    Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

    2012-07-01T23:59:59.000Z

    Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

  14. Watch for the red dot indicating

    E-Print Network [OSTI]

    > http:// > Watch for the red dot indicating expanded stories online sdm.mit.edu/pulse continued its facilities by constructing the European Extremely Large Telescope (E-ELT) on a mountain in Chile isolated from the grid. The planned construction of the E-ELT and the challenges faced by the current

  15. Author Proof Plants on red alert

    E-Print Network [OSTI]

    Schaefer, Martin

    Author Proof A Plants on red alert: do insects pay attention? H. Martin Schaefer* and Gregor Rolshausen Summary Two recent hypotheses have proposed that non-green plant colouration evolved as a defence against herbi- vores, either as protective colouration promoting handi- cap signals indicating plant

  16. The FIRST-2MASS Red Quasar Survey

    SciTech Connect (OSTI)

    Glikman, E; Helfand, D J; White, R L; Becker, R H; Gregg, M D; Lacy, M

    2007-06-28T23:59:59.000Z

    Combining radio observations with optical and infrared color selection--demonstrated in our pilot study to be an efficient selection algorithm for finding red quasars--we have obtained optical and infrared spectroscopy for 120 objects in a complete sample of 156 candidates from a sky area of 2716 square degrees. Consistent with our initial results, we find our selection criteria--J-K > 1.7,R-K > 4.0--yield a {approx} 50% success rate for discovering quasars substantially redder than those found in optical surveys. Comparison with UVX- and optical color-selected samples shows that {approx}> 10% of the quasars are missed in a magnitude-limited survey. Simultaneous two-frequency radio observations for part of the sample indicate that a synchrotron continuum component is ruled out as a significant contributor to reddening the quasars spectra. We go on to estimate extinctions for our objects assuming their red colors are caused by dust. Continuum fits and Balmer decrements suggest E(B-V) values ranging from near zero to 2.5 magnitudes. Correcting the K-band magnitudes for these extinctions, we find that for K {le} 14.0, red quasars make up between 25% and 60% of the underlying quasar population; owing to the incompleteness of the 2MASS survey at fainter K-band magnitudes, we can only set a lower limit to the radio-detected red quasar population of > 20-30%.

  17. Carta de Servicios Red de Bibliotecas

    E-Print Network [OSTI]

    Bibliotecas que pueden pertenecer a la Red, en la que se realizan los trabajos técnicos precisos para bibliotecarios que permitan el acceso a la información, ya sea de forma presencial o a distancia. servicios para trabajo en grupo. · Préstamo personal Permite a los usuarios utilizar las colecciones de su

  18. The Red Planet Mars is noticeable

    E-Print Network [OSTI]

    Walter, Frederick M.

    the melting polar ice, and ­ to distribute the water among the oases #12;Camille Flammarion (1884) #12;Chesley Viewed through a telescope: ·Mars has white polar caps ·Mars has dark (greenish) and bright (red;Northern Polar Cap in Spring #12;The Facts of Mars · mass = 0.11M · radius = 0.53 R · density = 3.9 gm/cm3

  19. Healthy Plate Red onion, rhubarb, radicchio,

    E-Print Network [OSTI]

    Bogyo, Matthew

    , bananas, kiwi, figs, watermelon Whole Grains & Fruit Combination Ideas: Poultry, fish, beans, lentils Beans + Spinach + Tomato Sauce Wild Rice + Lentils + Red Onion + Summer Squash Spring Rolls (recipe ROASTED LENTILS For the Rolls Rice wrapping paper Pan of water Veggies of choice (i.e. carrots, jalapeños

  20. MODELING BLOOD FLOW IN THE CARDIOVASCULAR

    E-Print Network [OSTI]

    Olufsen, Mette Sofie

    MODELING BLOOD FLOW IN THE CARDIOVASCULAR SYSTEM MA432 ­ Spring 2013 Department of Mathematics (Greek),...; Two distinct types of blood were thought to exist: § "Nutritive blood" was thought to be made by the liver and carried through veins to the organs, where it was consumed § "Vital blood

  1. Blood Management Using Approximate Linear Programming

    E-Print Network [OSTI]

    Shenoy, Prashant

    Blood Management Using Approximate Linear Programming Marek Petrik and Shlomo Zilberstein January 13th, 2009 Marek Petrik and Shlomo Zilberstein () Blood Management Using Approximate Linear ProgrammingJanuary 13th, 2009 1 / 36 #12;Blood Inventory Management Problem Regional blood banks: Aggregate

  2. The Centre for Blood Research Seminar Series

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Seminar Series Wednesday, March 13th, 2013 LSC 3 - Life Sciences "PARticipating in Metalloprotease Signaling in Blood Vessels" When plaques coating blood vessel walls rupture and expose collagen, platelets spring into action to form a blood clot at the damaged site. Dr. Kuliopulois

  3. MODELING BLOOD FLOW IN THE CARDIOVASCULAR

    E-Print Network [OSTI]

    Olufsen, Mette Sofie

    MODELING BLOOD FLOW IN THE CARDIOVASCULAR SYSTEM MA325 ­ Spring 2013 Department of Mathematics (Greek),...; Two distinct types of blood were thought to exist: § Nutritive blood was thought to be made by the liver and carried through veins to the organs, where it was consumed § Vital blood was thought

  4. E-Print Network 3.0 - aux red oils Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Environmental Sciences and Ecology 22 Red Leaf Resources and the Commercialization of Oil Shale Summary: Red Leaf Resources and the Commercialization of Oil Shale 12;About Red...

  5. WHEN THE BLUE-GREEN WATERS TURN RED

    E-Print Network [OSTI]

    WHEN THE BLUE-GREEN WATERS TURN RED Historical Flooding in Havasu Creek, Arizona U.S. GEOLOGICAL OF RECLAMATION #12;WHEN THE BLUE-GREEN WATERS TURN RED Historical Flooding in Havasu Creek, Arizona By THEODORE S

  6. Red-luminescent europium (III) doped silica nanoshells: synthesis,

    E-Print Network [OSTI]

    Kummel, Andrew C.

    Red-luminescent europium (III) doped silica nanoshells: synthesis, characterization(6), 066012 (June 2011) Red-luminescent europium (III) doped silica nanoshells: synthesis, characterization (SPIE). [DOI: 10.1117/1.3593003] Keywords: europium; silica; luminescent; nanoshells; endocytosis. Paper

  7. Introduction Operations Management of Blood Banking Systems Blood Banking Systems Network Design Supply Chain Network

    E-Print Network [OSTI]

    Nagurney, Anna

    Introduction Operations Management of Blood Banking Systems Blood Banking Systems Network Design Supply Chain Network Operations Management and Design of A Sustainable Blood Banking System Amir Masoumi of Massachusetts Amherst #12;Introduction Operations Management of Blood Banking Systems Blood Banking Systems

  8. Relative Changes of Cerebral Arterial and Venous Blood Volumes During Increased Cerebral Blood Flow

    E-Print Network [OSTI]

    Duong, Timothy Q.

    Relative Changes of Cerebral Arterial and Venous Blood Volumes During Increased Cerebral Blood Flow-Gi Kim1* Measurement of cerebral arterial and venous blood volumes during increased cerebral blood flow, and neuronally active conditions. In particular, the change in venous blood volume induced by neural activity

  9. Regulatory roles of endothelial cells in cancer

    E-Print Network [OSTI]

    Franses, Joseph W. (Joseph Wang)

    2011-01-01T23:59:59.000Z

    This thesis describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view ...

  10. Is the Missing Ultra-Red Material Colorless Ice?

    E-Print Network [OSTI]

    W. M. Grundy

    2008-11-14T23:59:59.000Z

    The extremely red colors of some transneptunian objects and Centaurs are not seen among the Jupiter family comets which supposedly derive from them. Could this mismatch result from sublimation loss of colorless ice? Radiative transfer models show that mixtures of volatile ice and nonvolatile organics could be extremely red, but become progressively darker and less red as the ice sublimates away.

  11. `Save Our Squirrels' (SOS) A Red Alert North England Project

    E-Print Network [OSTI]

    `Save Our Squirrels' (SOS) A Red Alert North England Project objectives The red squirrel is Britain in England. Action is needed if numbers are to be stabilised. The `Save Our Squirrels' Project (SOS) was set targeted area works with partners and woodland owners to fight to save the red squirrel. We

  12. Red Leaf Resources and the Commercialization of Oil Shale

    E-Print Network [OSTI]

    Utah, University of

    Red Leaf Resources and the Commercialization of Oil Shale #12;About Red Leaf Resources 2006 Company commercial development field activities #12;Highlights Proven, Revolutionary Oil Shale Extraction Process Technology Significant Owned Oil Shale Resource #12;· The executive management team of Red Leaf Resources

  13. Identification and analysis of cellular factors involved in v-Abl transformation of B lineage cells

    E-Print Network [OSTI]

    Yu, Jason

    2013-01-01T23:59:59.000Z

    children with acute lymphoblastic leukemia. Blood 97, 3925-B-cell lineage acute lymphoblastic leukemia. Cancer Res. 70,the response of acute lymphoblastic leukemia cells to

  14. Carta de Servicios Red de Bibliotecas

    E-Print Network [OSTI]

    pertenecer a la Red, en la que se realizan los trabajos técnicos precisos para proporcionar a los usuarios el a la información, ya sea de forma presencial o a distancia. servicios Información, orientación y también con salas para fondos especiales, de investigadores o para trabajo en grupo. · Préstamo personal

  15. From Red Tally to Yellow Paper

    E-Print Network [OSTI]

    Uebach, Helga

    2008-01-01T23:59:59.000Z

    by the convocation of many male able-bodied adults for registration (pha-los mang-pho). – Year 718/719: The establishment of the Red Tally of the former principality of Dags-po marks its complete inclusion... number of tallies for its files. In concluding it can be said that the fact that paper was officially introduced in Tibet for administrative purposes in the military organisation does not come as a surprise, since her power was built on her military...

  16. The Application of Flow Cytometry to Examine Damage Clearance in Stem Cells From Whole-Body Irradiated Mice

    SciTech Connect (OSTI)

    Marples, Brian; Kovalchuk, Olga; McGonagle, Michele; Martinez, Alvaro; Wilson, George, D.

    2010-02-26T23:59:59.000Z

    The bone marrow contains many types of cells. Approximately 1-2% of these cells are critical for life, these are the so-called ‘bone marrow stem cells’ which divide indefinitely to produce platelets, red blood cells and white blood cells. Death of the bone marrow stem cells results in a diminished ability of the organism to make new blood cell components and can be fatal without medical intervention, such as a bone marrow transplant. Bone marrow stem cells are considered to be particularly sensitive to radiation injury. Therefore, it is important to understand how these cells response to total body radiation exposure and how these cells can be protected from radiation damage. The aim of this project was to determine if these critical cells in the bone marrow are susceptible to short-term and long-term injury after a whole-body exposure to a sub-lethal low dose of ionizing radiation. The overall aims were to determine if the extent of injury produced by the sub-lethal radiation exposure would be cleared from the stem cells and therefore present no long- term genetic risk to the organism, or if the radiation injury persisted and had an adverse long-term consequences for the cell genome. This research question is of interest in order to define the risks to exposed persons after occupational, accidental or terrorism-related sub-lethal low-dose radiation exposures. The novel aspect of this project was the methodology used to obtain the bone marrow stem cell-like cells and examining the outcomes of sub-lethal low-dose radiation in a mammalian animal model. Four radiation treatments were used: single treatments of 0.01Gy, 0.1 Gy, 1 Gy and ten treatments of 0.1 Gy given over 10 days. Bone marrow stem cell-like cells were then harvested 6 hours, 24 hours and 24 days later. The levels of radiation-induced cell death, damage to DNA and permanent changes to cellular DNA were measured in the isolated stem cell-like cells after each radiation treatment and time point and then the results were compared. As expected, the largest radiation dose produced the greatest level of damage but a linear relationship did not exist between cellular effects and radiation dose. The low dose exposures appeared to be more efficient at producing damage than the highest dose when normalized for the initial extent of damage. Additionally, immune stimulation given prior to radiation exposure appeared to protect the critical bone marrow stem cell population from radiation injury. The data suggest that the response of bone marrow stem-cell like cells to radiation injury is dependent on the extent of the initial levels of damage and the effects of total-body low-dose exposures can not be predicted by extrapolating from high dose exposures. This research has provided new information about the radiation sensitivity of bone marrow stem cell-like cells following total-body exposures, and suggests that these critical cells might be more sensitive to radiation than more mature cells in the bone marrow. Further work is need with intermediate radiation doses to confirm this conclusion.

  17. How to make dried blood dots for genetic studies

    E-Print Network [OSTI]

    Schall, Joseph J.

    How to make dried blood dots for genetic studies If a vertebrate is in-hand, and blood being taken, it is easy to make both a blood smear and dried blood dots. Modern research on malaria parasites demands that BOTH a blood smear and blood samples be taken. Blood can be stored in lysis buffers of various kinds

  18. Differential white cell count by centrifugal microfluidics.

    SciTech Connect (OSTI)

    Sommer, Gregory Jon; Tentori, Augusto M.; Schaff, Ulrich Y.

    2010-07-01T23:59:59.000Z

    We present a method for counting white blood cells that is uniquely compatible with centrifugation based microfluidics. Blood is deposited on top of one or more layers of density media within a microfluidic disk. Spinning the disk causes the cell populations within whole blood to settle through the media, reaching an equilibrium based on the density of each cell type. Separation and fluorescence measurement of cell types stained with a DNA dye is demonstrated using this technique. The integrated signal from bands of fluorescent microspheres is shown to be proportional to their initial concentration in suspension. Among the current generation of medical diagnostics are devices based on the principle of centrifuging a CD sized disk functionalized with microfluidics. These portable 'lab on a disk' devices are capable of conducting multiple assays directly from a blood sample, embodied by platforms developed by Gyros, Samsung, and Abaxis. [1,2] However, no centrifugal platform to date includes a differential white blood cell count, which is an important metric complimentary to diagnostic assays. Measuring the differential white blood cell count (the relative fraction of granulocytes, lymphocytes, and monocytes) is a standard medical diagnostic technique useful for identifying sepsis, leukemia, AIDS, radiation exposure, and a host of other conditions that affect the immune system. Several methods exist for measuring the relative white blood cell count including flow cytometry, electrical impedance, and visual identification from a stained drop of blood under a microscope. However, none of these methods is easily incorporated into a centrifugal microfluidic diagnostic platform.

  19. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Coronary Heart Disease C oronary is available from the National Heart, Lung, and Blood Institute (NHLBI) Web site at www.nhlbi.nih.gov (under

  20. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Atherosclerosis A therosclerosis, Lung, and Blood Institute (NHLBI) Web site at www.nhlbi.nih.gov (under Health Information

  1. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : What You Need To Know About High on lowering cholesterol is available from the National Heart, Lung, and Blood Institute (NHLBI) Web site

  2. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Healthy Sleep S leep is not just information on healthy sleep and sleep disorders is available from the National Heart, Lung, and Blood

  3. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Facts About Healthy Weight Why indicator of your risk for a variety of diseases. To check your BMI, use the National Heart, Lung, and Blood

  4. artificial blood vessel: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: HEART AND BLOOD VESSELS CARDIOVASCULARCARDIOVASCULAR SYSTEMSYSTEM SYSTEM COMPONENTS Heart pumps blood though blood vessels where exchanges can take place...

  5. Blood Peptidome-Degradome Profile of Breast Cancer. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Blood Peptidome-Degradome Profile of Breast Cancer. Blood Peptidome-Degradome Profile of Breast Cancer. Abstract: We report on the degradomic-peptidomic insights into blood plasma...

  6. Blood guilt and its legacy

    E-Print Network [OSTI]

    Claxton, Christy Paige Louise

    1992-01-01T23:59:59.000Z

    Shange, Although the introduction is not the main body of this thesis, it is a frame clarifying the drama. TABLE OF CONTENTS ABSTRACT TABLE OF CONTENTS. . INTRODUCTION. . BLOOD GUILT. WORKS CONSULTED. . . VITA. . Page 111 23 95 97..., " brought on by the patriarchal assumptions of society is being put to the public's attention more and more (63-64). Even so, it is easier to change public structures than private attitudes. My play is an attempt to bring the problem of gender violence...

  7. Elec 331 -Blood Pressure Heart Valves

    E-Print Network [OSTI]

    Pulfrey, David L.

    Elec 331 - Blood Pressure 1 Heart Valves · Atrio-Ventricular (AV) ­ Bicuspid / Mitral (left - Blood Pressure 2 Phases of the Heart · Systole (Max BP) ­ Ventricle contracted ­ Aorta inflated 331 - Blood Pressure 3 Korotkov Phases / Sounds S D P P Nothing Sharp Swish Faint Nothing 0 1 2-3 4 5

  8. Using PPG Morphology to Detect Blood Sequestration

    E-Print Network [OSTI]

    Linder, Stephen

    Using PPG Morphology to Detect Blood Sequestration Stephen P. Linder1 , Suzanne M. Wendelken, Susan been shown to vary with the respiratory cycle, but changes in the morphology caused by blood of changes in blood sequestration cause by changes in posture by monitor- ing how the shape of individual

  9. Blue, green, orange, and red upconversion laser

    DOE Patents [OSTI]

    Xie, Ping (San Jose, CA); Gosnell, Timothy R. (Sante Fe, NM)

    1998-01-01T23:59:59.000Z

    A laser for outputting visible light at the wavelengths of blue, green, orange and red light. This is accomplished through the doping of a substrate, such as an optical fiber or waveguide, with Pr.sup.3+ ions and Yb.sup.3+ ions. A light pump such as a diode laser is used to excite these ions into energy states which will produce lasing at the desired wavelengths. Tuning elements such as prisms and gratings can be employed to select desired wavelengths for output.

  10. Blue, green, orange, and red upconversion laser

    DOE Patents [OSTI]

    Xie, P.; Gosnell, T.R.

    1998-09-08T23:59:59.000Z

    A laser is disclosed for outputting visible light at the wavelengths of blue, green, orange and red light. This is accomplished through the doping of a substrate, such as an optical fiber or waveguide, with Pr{sup 3+} ions and Yb{sup 3+} ions. A light pump such as a diode laser is used to excite these ions into energy states which will produce lasing at the desired wavelengths. Tuning elements such as prisms and gratings can be employed to select desired wavelengths for output. 11 figs.

  11. Red Sun Energy | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit with form History Facebook iconQuito,JumpReactionEnergy Data JamReconceptRed Sun

  12. RedFlow | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit with form History Facebook iconQuito,JumpReactionEnergy Data JamReconceptRed

  13. Red Canyon Wind Farm | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-f < RAPID‎ | Roadmap Jump to:bJumpRed Bank, New Jersey: EnergyCanyon

  14. Red Hills Wind Farm | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-f < RAPID‎ | Roadmap Jump to:bJumpRed Bank, New Jersey:

  15. Science On Tap - Red Wine and Mars

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiationImplementingnpitcheResearch BriefsTenney, OfficeScienceEarlyScience On Tap - Red

  16. HRC Exec. Recomm./FDA/Blood Ban End Discrimination against Gay and Bisexual Blood Donors

    E-Print Network [OSTI]

    Khan, Javed I.

    HRC Exec. Recomm./FDA/Blood Ban End Discrimination against Gay and Bisexual Blood Donors Issue with men ("MSM") from donating blood is discriminatory and medically unnecessary. Short Answer The FDA's Center for Biologics Evaluation and Research ("CBER") should abolish its blood donation deferral policy

  17. Blood Pressure and Blood Flow Variation during Postural Change from Sitting to Standing: Model

    E-Print Network [OSTI]

    1 Blood Pressure and Blood Flow Variation during Postural Change from Sitting to Standing: Model that regulates blood pressure, and cerebral autoregulation that maintains cerebral perfusion. We present a mathematical model that can predict dynamic changes observed in beat-to-beat arterial blood pressure and middle

  18. Red Band Needle Blight Programme Red Band Needle Blight of Pine Programme Group

    E-Print Network [OSTI]

    and that the private 1 | Paper 1 - Minutes | Debbie Erskine | 23/01/2009 #12;Red Band Needle Blight Programme Group Group England Working Group Wales Working Group RBNB Operational GB Working Group (including private Groups would only meet on an ad hoc basis and the structure was agreed. Action: Jim/Roddie to re

  19. RED MOUNTAIN BAR PUMPED STOR AGE PR OJEC T Red Mountain Bar Pumped Storage Project

    E-Print Network [OSTI]

    Laughlin, Robert B.

    a pumped storage project to generate electricity during peak demand. The proposed Red Mountain Bar Pumped from a lower reservoir to an upper reservoir when demand and price for electricity is low. Water the next day. These projects are uniquely suited for generating power when demand for electricity is high

  20. Summer Enrollment Blue=Old Program, Red=New Program

    E-Print Network [OSTI]

    Gering, Jon C.

    Summer Enrollment Blue=Old Program, Red=New Program 1559 14181358 1304 1166 1245 0 200 400 600 800;Summer Sections Offered Blue=Old Program, Red=New Program 142 135 160158 180 200 0 50 100 150 200 250 Generated Blue=Old Program, Red=New Program 5643 5983.5 5463 4953 5985.5 6961 0 1000 2000 3000 4000 5000

  1. Red rice control in rice using herbicides plus safeners

    E-Print Network [OSTI]

    Price, James Bain

    1977-01-01T23:59:59.000Z

    RED RICE CONTROL IN RICE USING HERBICIDES PLUS SAFENERS A Thesis by JAMES BAIN PRICE, IV Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE May 1977 Major... Subject: Agronomy RED RICE CONTROL IN RICE USING HERBICIDES PLUS SAFENERS A Thesis by JAMES BAIN PRICE, IV Approved as to style and content by: (Chairman of Committee Head of Department (Member) (Member) Memb May 1977 ABSTRACT Red Rice...

  2. Infra-Red Surface-Plasmon-Resonance technique for biological studies

    E-Print Network [OSTI]

    V. Lirtsman; M. Golosovsky; D. Davidov

    2007-11-18T23:59:59.000Z

    We report on a Surface-Plasmon-Resonance (SPR) technique based on Fourier -Transform - Infra - Red (FTIR) spectrometer. In contrast to the conventional surface plasmon technique, operating at a fixed wavelength and a variable angle of incidence, our setup allows the wavelength and the angle of incidence to be varied simultaneously. We explored the potential of the SPR technique in the infrared for biological studies involving aqueous solutions. Using computer simulations, we found the optimal combination of parameters (incident angle, wavelength) for performing this task. Our experiments with physiologically important glucose concentrations in water and in human plasma verified our computer simulations. Importantly, we demonstrated that the sensitivity of the SPR technique in the infrared range is not lower and in fact is even higher than that for visible light. We emphasize the advantages of infra red SPR for studying glucose and other biological molecules in living cells.

  3. The Centre for Blood Research Jos Lpez, MD

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research José López, MD Executive Vice-President of Research Puget Sound Blood for Blood Research Von Willebrand factor (VWF) is the largest protein in the blood and involved in both

  4. Integrated Culture of Seaweeds and Red Abalone in Monterey Harbor

    E-Print Network [OSTI]

    Graham, Michael H.

    2008-01-01T23:59:59.000Z

    Project Hypotheses (1) Red algae and kelp can be effectivelydiets are superior to all kelp diets in enhancing farmedlaboratory methods for seeding kelp zoospores onto string

  5. Nationwide: Slashing Red Tape To Speed Solar Deployment for Homes...

    Broader source: Energy.gov (indexed) [DOE]

    Slashing Red Tape To Speed Solar Deployment for Homes and Businesses While solar panels, inverters and other hardware are more affordable than ever before (the average cost of...

  6. aqaba northern red: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for a population of extremely red stellar objects extracted from the point-source catalogue of the INT Photometric H-Alpha Survey (IPHAS) of the northern galactic...

  7. NNSA Releases UPF "Red Team" Report | National Nuclear Security...

    National Nuclear Security Administration (NNSA)

    UPF "Red Team" Report | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering the...

  8. Redding Electric- Residential and Commercial Energy Efficiency Rebate Program

    Broader source: Energy.gov [DOE]

    Redding Electric Utility offers a variety of financial incentives for energy efficiency through its Earth Advantage Rebate Program. Rebates are for weatherization measures, HVAC equipment, and...

  9. american red squirrels: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    274 www.redsquirrelsofthehighlands.co.uk RED SQUIRRRELS OF THE HIGHLANDS End of Project Renewable Energy Websites Summary: by internal FCS process Training for health...

  10. aqaba red sea: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    is uncertain due to global warming and repeated bleaching a century. Keywords: climate change, coral bleaching, coral reefs, Gulf of Aqaba, Red Sea Received 9 January. The latter,...

  11. Solid State Solar Cells Based On Tio2 Sensitized With Natural Pigment Extracted From the Anthurium

    E-Print Network [OSTI]

    G. R. A. Kumara

    Abstract: The purpose of this experiment was to create functional dye-sensitized solid state solar cells using natural pigments extracted from the blood red Anthurium as the electron donating species. Natural dye was extracted and adsorbed onto a nano-porous titania substrate. Platinum coated glass was used as the counter electrode. The cells were prepared using drop coating method to get a thickness around 10?m using 25 nm size TiO2 particles. Using the extracted natural dye we have been able to obtain high efficiencies with CuSCN over CuI hole conductor. The prepared cells show open circuit voltage (Voc) of 0.46 V and 0.43 of fill factor (FF) with an overall efficiency (?) of 0.34 % for CuSCN over the CuI hole conductor. Nevertheless short circuit current density (Jsc) was 2.37 mA cm-2 for CuI, it was 1.73 mA cm-2 for CuSCN. Key words: Dye Sensitized Solid State Solar Cells, Cyanidin, Anthurium, hole conductor. 1.

  12. Microsphere estimates of blood flow: Methodological considerations

    SciTech Connect (OSTI)

    von Ritter, C.; Hinder, R.A.; Womack, W.; Bauerfeind, P.; Fimmel, C.J.; Kvietys, P.R.; Granger, D.N.; Blum, A.L. (Univ. of the Witwatersrand, Johannesburg (South Africa) Louisianna State Univ. Medical Center, Shreveport (USA) Universitaire Vaudois (Switzerland))

    1988-02-01T23:59:59.000Z

    The microsphere technique is a standard method for measuring blood flow in experimental animals. Sporadic reports have appeared outlining the limitations of this method. In this study the authors have systematically assessed the effect of blood withdrawals for reference sampling, microsphere numbers, and anesthesia on blood flow estimates using radioactive microspheres in dogs. Experiments were performed on 18 conscious and 12 anesthetized dogs. Four blood flow estimates were performed over 120 min using 1 {times} 10{sup 6} microspheres each time. The effects of excessive numbers of microspheres pentobarbital sodium anesthesia, and replacement of volume loss for reference samples with dextran 70 were assessed. In both conscious and anesthetized dogs a progressive decrease in gastric mucosal blood flow and cardiac output was observed over 120 min. This was also observed in the pancreas in conscious dogs. The major factor responsible for these changes was the volume loss due to the reference sample withdrawals. Replacement of the withdrawn blood with dextran 70 led to stable blood flows to all organs. The injection of excessive numbers of microspheres did not modify hemodynamics to a greater extent than did the injection of 4 million microspheres. Anesthesia exerted no influence on blood flow other than raising coronary flow. The authors conclude that although blood flow to the gastric mucosa and the pancreas is sensitive to the minor hemodynamic changes associated with the microsphere technique, replacement of volume loss for reference samples ensures stable blood flow to all organs over a 120-min period.

  13. Red Shift in a Laboraory Environment

    E-Print Network [OSTI]

    Yuriy A. Yatsunenko; Julian A. Budagov

    2011-03-04T23:59:59.000Z

    A hypotheses of energy loss for polarization of e-e+ vacuum by a photon passing interstellar space is considered. An excitation and relaxation of vacuum can't run with speed of light due to very small but finite fraction of e-e+ pair mass that creates a retardment in recuperation of deposited energy back to photon. This "forgotten" by many photons energy is finally splashed out in real space as a Relic Radiation. An assumption that such energy loss is proportional to a photon energy conforms to Hubble low of Red Shift and experimental data treated as accelerated expansion of Universe. A possibility of an observation of this type energy loss is considered at high-energy accelerators where energy deposition may reach up hundreds MeV in second.

  14. ACARYOCHLORIS EXPLAINING THE RIDDLE OF CHLOROPHYLL D IN RED ALGAE AND EXPANDING PAR FOR OXYGENIC PHOTOSYNTHESIS

    E-Print Network [OSTI]

    Oregon, University of

    ACARYOCHLORIS ­ EXPLAINING THE RIDDLE OF CHLOROPHYLL D IN RED ALGAE AND EXPANDING PAR FOR OXYGENIC strain is shown to live epi- phytically on the red alga Gelidium caulacantheum, which itself is harvested by the red alga. Availability of far red light, however, is relatively unaffected by DOM or red

  15. Checking Your Blood Sugar The only way to be sure your blood sugar is "just right" is to

    E-Print Network [OSTI]

    Checking Your Blood Sugar The only way to be sure your blood sugar is "just right" is to check it. Your blood sugar can be high and you may feel fine. If your blood sugar is high, it is damaging your blood vessels and hurting your body, even if you feel fine. #12; How can you check your blood sugar? One

  16. Ris-R-1513(EN) The "Red" Decline of Norway

    E-Print Network [OSTI]

    Risø-R-1513(EN) The "Red" Decline of Norway Spruce or "Røde Rødgraner" ­ Is it Ammonium Overload. Engvild Title: The "Red" Decline of Norway Spruce or "Røde Rødgraner" ­ Is it Ammonium Overload or Top" decline of Norway spruce (Picea abies) became a serious problem in plantations in Jutland on poor, sandy

  17. Natural England Commissioned Report NECR019 Review of red squirrel

    E-Print Network [OSTI]

    and offers expert and timely advice for future work programmes. Control of grey squirrels is identified and effective. Improve the way in which grey squirrel control, central to any red squirrel conservation project Laboratory, Sand Hutton, York YO41 1LZ (Consortium leader) Keywords - Red squirrel, grey squirrel, wildlife

  18. INHIBITION OF PHOTOSYNTHESIS IN CERTAIN ALGAE BY EXTREME RED LIGHT

    E-Print Network [OSTI]

    Govindjee

    INHIBITION OF PHOTOSYNTHESIS IN CERTAIN ALGAE BY EXTREME RED LIGHT GOVINDJEE, EUGENE RABINOWITCH. INTRODUCTION It was shown in preceding papers (9, 10) that when the unicellular red alga Por- phyridium), these algae, when exposed to monochromatic light (bands isolated by a grating monochromator, band half

  19. Molecular Cell, Volume 45 Supplemental Information

    E-Print Network [OSTI]

    van Oudenaarden, Alexander

    imaging of (A) FLO11 and PWR1, (A) FLO11 and ICR1, and (C) ICR1 and PWR1 transcripts in individual cells) and PWR1 (Cy5; red dots) transcripts in fields of intact individual WT cells. DAPI staining (blue) shows the locations of nuclei. (C) Merged fluorescence and DIC microscopy images show ICR1 (TMR; green dots) and PWR

  20. Light Induced Guard Cell Sunando Roy

    E-Print Network [OSTI]

    Albert, Réka

    Light Induced Guard Cell Signaling Sunando Roy #12;Guard cells and the stomata The tradeoff between water and carbon dioxide Roelfsema et. al. New Phytologist (2005) 167: 665 - 691 #12;The Light Signaling features · The blue light signaling carried out through ion channels · The red light signaling occurs

  1. Thermodynamics, Entropy, Information and the Efficiency of Solar Cells

    E-Print Network [OSTI]

    Abrams, Zeev R.

    2012-01-01T23:59:59.000Z

    IR Infra-Red I sc Short-circuit current I-V Current vs.contributes to the short-circuit current of the solar cell.term. Since the short-circuit current is directly

  2. The tumor microenvironment of B-cell chronic lymphocytic leukemia

    E-Print Network [OSTI]

    Chang, Hsu-Hsiang

    2008-01-01T23:59:59.000Z

    pathway distinct from that of SDF-1?. Blood. 2005; 106:1012-a proliferation-inducing ligand SDF – stromal cell-derivedstromal-cell derived factor-1 (SDF-1, also known as CXCL12)

  3. Detecting and molecular profiling cancer cells in patients

    E-Print Network [OSTI]

    Peterson, Vanessa M. (Vanessa Marie)

    2013-01-01T23:59:59.000Z

    Although tumor cells obtained from human patients by surgical biopsy, image-guided intervention, blood draws or fluid drainage (paracentesis, thoracentesis) are a valuable source for analyzing tumor cells, conventional ...

  4. FCS Guidance Note 33: Forest operations and red squirrels: November 2006 Forest operations and red squirrels in Scottish forests

    E-Print Network [OSTI]

    impacts on red squirrels. The survey, forest design and operational planning practices set outFCS Guidance Note 33: Forest operations and red squirrels: November 2006 1 Forest operations Guidance Note: Forest operations and wildlife in Scottish forests. This note sets out further advice on how

  5. Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

    E-Print Network [OSTI]

    Zervantonakisa, Ioannis K.

    Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although significant progress has been made in visualizing tumor cell motility in vivo, the underlying mechanism of cancer cell intravasation ...

  6. RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical...

    Broader source: Energy.gov (indexed) [DOE]

    RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical Challenges. RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical Challenges. RedSeal Comments...

  7. Device and method for automated separation of a sample of whole blood into aliquots

    DOE Patents [OSTI]

    Burtis, Carl A. (Oak Ridge, TN); Johnson, Wayne F. (Loudon, TN)

    1989-01-01T23:59:59.000Z

    A device and a method for automated processing and separation of an unmeasured sample of whole blood into multiple aliquots of plasma. Capillaries are radially oriented on a rotor, with the rotor defining a sample chamber, transfer channels, overflow chamber, overflow channel, vent channel, cell chambers, and processing chambers. A sample of whole blood is placed in the sample chamber, and when the rotor is rotated, the blood moves outward through the transfer channels to the processing chambers where the blood is centrifugally separated into a solid cellular component and a liquid plasma component. When the rotor speed is decreased, the plasma component backfills the capillaries resulting in uniform aliquots of plasma which may be used for subsequent analytical procedures.

  8. American Heart Month National High Blood

    E-Print Network [OSTI]

    FEBRUARY American Heart Month MAY National High Blood Pressure Education Month SEPTEMBER National Cholesterol Education Month Texas AgriLife Extension Service Texas A&M University System Eat Smart for Heart for Heart Health # P2-2 Risk Factors - High Blood Pressure # P2-3 Sodium is needed to. . . # P2-4 Sources

  9. Diabetes Education Program Blood Glucose Monitoring

    E-Print Network [OSTI]

    Oliver, Douglas L.

    Diabetes Education Program Blood Glucose Monitoring Self Blood Glucose Monitoring is an easy way to assess your diabetes control. This information will help you and your doctor see how your treatment plan in a very short amount of time with a simple finger prick. Your diabetes educator will help you select

  10. U-159: Red Hat Enterprise MRG Messaging Qpid Bug Lets Certain...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    9: Red Hat Enterprise MRG Messaging Qpid Bug Lets Certain Remote Users Bypass Authentication U-159: Red Hat Enterprise MRG Messaging Qpid Bug Lets Certain Remote Users Bypass...

  11. OBSERVATIONAL CONSTRAINTS ON RED AND BLUE HELIUM BURNING SEQUENCES

    SciTech Connect (OSTI)

    McQuinn, Kristen B. W.; Skillman, Evan D. [Department of Astronomy, School of Physics and Astronomy, 116 Church Street, S.E., University of Minnesota, Minneapolis, MN 55455 (United States); Dalcanton, Julianne J.; Weisz, Daniel R.; Williams, Benjamin F. [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Dolphin, Andrew E. [Raytheon Company, 1151 E. Hermans Road, Tucson, AZ 85706 (United States); Holtzman, Jon, E-mail: kmcquinn@astro.umn.edu [Department of Astronomy, New Mexico State University, Box 30001-Department 4500, 1320 Frenger Street, Las Cruces, NM 88003 (United States)

    2011-10-10T23:59:59.000Z

    We derive the optical luminosity, colors, and ratios of the blue and red helium burning (HeB) stellar populations from archival Hubble Space Telescope observations of nineteen starburst dwarf galaxies and compare them with theoretical isochrones from Padova stellar evolution models across metallicities from Z = 0.001 to 0.009. We find that the observational data and the theoretical isochrones for both blue and red HeB populations overlap in optical luminosities and colors and the observed and predicted blue to red HeB ratios agree for stars older than 50 Myr over the time bins studied. These findings confirm the usefulness of applying isochrones to interpret observations of HeB populations. However, there are significant differences, especially for the red HeB population. Specifically, we find (1) offsets in color between the observations and theoretical isochrones of order 0.15 mag (0.5 mag) for the blue (red) HeB populations brighter than M{sub V} {approx} -4 mag, which cannot be solely due to differential extinction; (2) blue HeB stars fainter than M{sub V} {approx} -3 mag are bluer than predicted; (3) the slope of the red HeB sequence is shallower than predicted by a factor of {approx}3; and (4) the models overpredict the ratio of the most luminous blue to red HeB stars corresponding to ages {approx}< 50 Myr. Additionally, we find that for the more metal-rich galaxies in our sample (Z {approx}> 0.5 Z{sub sun}), the red HeB stars overlap with the red giant branch stars in the color-magnitude diagrams, thus reducing their usefulness as indicators of star formation for ages {approx}> 100 Myr.

  12. TOWARD AUTOMATIC BLOOD SPATTER ANALYSIS IN CRIME SCENES

    E-Print Network [OSTI]

    Martin, Ralph R.

    TOWARD AUTOMATIC BLOOD SPATTER ANALYSIS IN CRIME SCENES A.R. Shen, G.J. Brostow, R. Cipolla: Blood Spatter, Origin Localisation, Metrology Abstract Some scenes of violent crime contain blood stains. Blood spatter stains occur when blood falls passively due to force being applied to a body

  13. Blood mixer -Optimix Plus Plasma storage freezer -Forma 8097

    E-Print Network [OSTI]

    Strynadka, Natalie

    Equipment: Blood mixer - Optimix Plus Plasma storage freezer - Forma 8097 Blood storage cabinet - Forma 3632 Platelet storage shaker- Forma 4720 Tubing heat sealer - Hematron III Centrifuge for blood allows for the safe collection of blood, the separation and storage of blood components, and for analysis

  14. Infra-Red Process for Colour Fixation on Fabrics

    E-Print Network [OSTI]

    Biau, D.; Raymond, D. J.

    1983-01-01T23:59:59.000Z

    Infra-red radiations find wide application in industrial processes as heating, drying, stoving and forming. The results are often far better than those from the other techniques: convection oven, gas IR etc . They come from the electric IR specific...

  15. Red Ink : open source financial analytics for people & communities

    E-Print Network [OSTI]

    O'Toole, Ryan (Ryan Michael)

    2010-01-01T23:59:59.000Z

    Red Ink is an open source social-financial web-service that enables people to share, aggregate, analyze, visualize and publish their financial transactions as individuals and ad-hoc groups, through data sharing campaigns. ...

  16. Buoyancy-driven circulation in the Red Sea

    E-Print Network [OSTI]

    Zhai, Ping, Ph. D. Massachusetts Institute of Technology

    2014-01-01T23:59:59.000Z

    This thesis explores the buoyancy-driven circulation in the Red Sea, using a combination of observations, as well as numerical modeling and analytical method. The first part of the thesis investigates the formation mechanism ...

  17. area red sea: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to compiling a Red Data Book of Threatened Biotopes of the Baltic Sea Area. The assessment has been made by numerous experts on marine and coastal ecology and taxonomy from...

  18. CAPTURING TAGGED RED SALMON WITH PULSED DIRECT CURRENT

    E-Print Network [OSTI]

    the electrodes were forced to move towards the positive electrode, placed in slack water 3 feet deep close pressing problems now facing biologists working on research and man- agement of our salmon resources. Red

  19. Red River Valley REA- Heat Pump Loan Program

    Broader source: Energy.gov [DOE]

    The Red River Valley Rural Electric Association (RRVREA) offers a loan program to its members for air-source and geothermal heat pumps. Loans are available for geothermal heat pumps at a 5% fixed...

  20. Infra-Red Process for Colour Fixation on Fabrics 

    E-Print Network [OSTI]

    Biau, D.; Raymond, D. J.

    1983-01-01T23:59:59.000Z

    Infra-red radiations find wide application in industrial processes as heating, drying, stoving and forming. The results are often far better than those from the other techniques: convection oven, gas IR etc . They come from the electric IR specific...

  1. Imazethapyr: red rice control and resistance, and environmental fate

    E-Print Network [OSTI]

    Avila, Luis Antonio de

    2005-11-01T23:59:59.000Z

    Imazethapyr was recently approved for use in rice, but limited information is available regarding its efficacy, environmental fate or potential red rice resistance. Therefore, experiments were conducted to 1) determine the effect of flooding time...

  2. SEISMIC DIAGNOSTICS OF RED GIANTS: FIRST COMPARISON WITH STELLAR MODELS

    SciTech Connect (OSTI)

    Montalban, J.; Miglio, A.; Noels, A.; Scuflaire, R. [Institut d'Astrophysique et Geophysique de l'Universite de Liege, Allee du six Aout, 17 B-4000 Liege (Belgium); Ventura, P. [Osservatorio Astronomico di Roma-INAF, via Frascati 33, Monteporzio Catone, Rome (Italy)

    2010-10-01T23:59:59.000Z

    The clear detection with CoRoT and KEPLER of radial and non-radial solar-like oscillations in many red giants paves the way for seismic inferences on the structure of such stars. We present an overview of the properties of the adiabatic frequencies and frequency separations of radial and non-radial oscillation modes for an extended grid of models. We highlight how their detection allows a deeper insight into the internal structure and evolutionary state of red giants. In particular, we find that the properties of dipole modes constitute a promising seismic diagnostic tool of the evolutionary state of red giant stars. We compare our theoretical predictions with the first 34 days of KEPLER data and predict the frequency diagram expected for red giants in the CoRoT exofield in the galactic center direction.

  3. Interpreting the Clustering of Distant Red Galaxies

    SciTech Connect (OSTI)

    Tinker, Jeremy L.; /BCCP, Berkeley; Wechsler, Risa H.; /KIPAC, Menlo Park /SLAC; Zheng, Zheng; /Princeton, Inst. Advanced Study

    2009-08-03T23:59:59.000Z

    We analyze the angular clustering of z {approx} 2.3 distant red galaxies (DRGs) measured by Quadri et al. (2008). We find that, with robust estimates of the measurement errors and realistic halo occupation distribution modeling, the measured clustering can be well fit within standard halo occupation models, in contrast to previous results. However, in order to fit the strong break in w({theta}) at {theta} = 10{double_prime}, nearly all satellite galaxies in the DRG luminosity range are required to be DRGs. Within this luminosity-threshold sample, the fraction of galaxies that are DRGs is {approx} 44%, implying that the formation of DRGs is more efficient for satellite galaxies than for central galaxies. Despite the evolved stellar populations contained within DRGs at z = 2.3, 90% of satellite galaxies in the DRG luminosity range have been accreted within 500 Myr. Thus, satellite DRGs must have known they would become satellites well before the time of their accretion. This implies that the formation of DRGs correlates with large-scale environment at fixed halo mass, although the large-scale bias of DRGs can be well fit without such assumptions. Further data are required to resolve this issue. Using the observational estimate that {approx} 30% of DRGs have no ongoing star formation, we infer a timescale for star formation quenching for satellite galaxies of 450 Myr, although the uncertainty on this number is large. However, unless all non-star forming satellite DRGs were quenched before accretion, the quenching timescale is significantly shorter than z {approx} 0 estimates. Down to the completeness limit of the Quadri et al sample, we find that the halo masses of central DRGs are {approx} 50% higher than non-DRGs in the same luminosity range, but at the highest halo masses the central galaxies are DRGs only {approx} 2/3 of the time.

  4. Analysis of records of embryo production in Red Brahman cows

    E-Print Network [OSTI]

    Riano Rocha, Edgar Hernando

    2005-11-01T23:59:59.000Z

    ANALYSIS OF RECORDS OF EMBRYO PRODUCTION IN RED BRAHMAN COWS A Thesis by EDGAR HERNANDO RIANO ROCHA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... August 2005 Major Subject: Physiology of Reproduction ANALYSIS OF RECORDS OF EMBRYO PRODUCTION IN RED BRAHMAN COWS A Thesis by EDGAR HERNANDO RIANO ROCHA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment...

  5. Inheritance of some characters in red rice (Oryza sativa L.)

    E-Print Network [OSTI]

    Livore, Alberto Blas

    1985-01-01T23:59:59.000Z

    INHERITANCE OF SOME CHARACTERS IN RED RICE (ORYZA SATIVA L. ) A Thesis ALBERTO BLAS LIVORE Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1985... Major Subject: Plant Breeding INHERITANCE OF SOME CHARACTERS IN RED RICE (ORYZA SATIVA L. ) A Thesis ALBERTO BLAS LIVORE Approved as to style and content by: J. Bockholt Co-Chairman) James W. Stansel (Co-Chairman) Charles N. Bollich (Member...

  6. Increasing herbicide selectivity between rice and red rice

    E-Print Network [OSTI]

    Koetz, Paul Howard

    1982-01-01T23:59:59.000Z

    INCREASING HERBICIDE SEIZCTIVITY BETWEEN RICE AND RED RICE A Thesis by PAUL HOWARD KOETZ Submitted to the Graduate College of Texas AAN University 'n partial fulfillment of the requirement for the degree of' WASTER OF SCIENCE August 1982... major Subject: Agronomy INCREASING HERBICIDE SELECTIVITY BETWEEN RICE AND RED RICE A Thesis by PAUL HOWARD KOETZ Approved as to style and content by (Chairman of Committee) (Member (Member) (Head of Departmen August l982 ABSTRACT Increasing...

  7. automatic blood pressure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    o Reinfuse the patient's blood slowly, no faster than 1mL per second, by pressing the plunger back Kay, Mark A. 325 Automatic Detection of Blood versus non-Blood Regions on...

  8. varicose veins smoking obesity swine flu high blood pressure

    E-Print Network [OSTI]

    Diggle, Peter J.

    varicose veins smoking obesity swine flu high blood pressure parkinson's stress depression muscle stiffness heart attack asthma low blood pressure alzheimer's cancer diabetes kidney failure dementia smoking obesity swine flu high blood pressure parkinson's stress depression muscle stiffness heart attack

  9. Clinical feasibility of Raman spectroscopy for quantitative blood glucose measurement

    E-Print Network [OSTI]

    Kong, Chae-Ryon

    2011-01-01T23:59:59.000Z

    Diabetes mellitus is a leading cause of morbidity and mortality worldwide, and close monitoring of blood glucose levels is crucial for its diagnosis and management. Currently, blood glucose monitoring is done by blood ...

  10. Red Storm usage model :Version 1.12.

    SciTech Connect (OSTI)

    Jefferson, Karen L.; Sturtevant, Judith E.

    2005-12-01T23:59:59.000Z

    Red Storm is an Advanced Simulation and Computing (ASC) funded massively parallel supercomputer located at Sandia National Laboratories (SNL). The Red Storm Usage Model (RSUM) documents the capabilities and the environment provided for the FY05 Tri-Lab Level II Limited Availability Red Storm User Environment Milestone and the FY05 SNL Level II Limited Availability Red Storm Platform Milestone. This document describes specific capabilities, tools, and procedures to support both local and remote users. The model is focused on the needs of the ASC user working in the secure computing environments at Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and SNL. Additionally, the Red Storm Usage Model maps the provided capabilities to the Tri-Lab ASC Computing Environment (ACE) requirements. The ACE requirements reflect the high performance computing requirements for the ASC community and have been updated in FY05 to reflect the community's needs. For each section of the RSUM, Appendix I maps the ACE requirements to the Limited Availability User Environment capabilities and includes a description of ACE requirements met and those requirements that are not met in that particular section. The Red Storm Usage Model, along with the ACE mappings, has been issued and vetted throughout the Tri-Lab community.

  11. adjusted blood requirement: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood agar because of the high cost and inhospitable conditions for raising wool sheep or horses to supply blood. Many pathogens either fail to grow entirely or exhibit...

  12. ambulatory blood pressure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    regulation is achieved for pre-loop blood glucose control using dual subcutaneous infusion of insulin and glucagon in ambulatory diabetic 3 Understanding Blood Pressure...

  13. alter systemic blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Physics and Astronomy Yodh, Arjun G. 127 Photoacoustic microscopy of blood pulse Chenghung Yeh Engineering Websites Summary: , by simultaneously monitoring blood flow...

  14. Assessment of Biomass Energy Opportunities for the Red Lake Band of Chippewa Indians

    SciTech Connect (OSTI)

    Scott Haase (McNeil Technologies, Inc)

    2005-09-30T23:59:59.000Z

    Assessment of biomass energy and biobased product manufacturing opportunities for the Red Lake Tribe.

  15. Control of blood clotting using gold nanorods

    E-Print Network [OSTI]

    De Puig Guixé, Helena

    2013-01-01T23:59:59.000Z

    We have developed a method to externally control blood clotting using gold nanoparticles. Gold nanorods (NRs) have unique size and shape-dependent optical properties that can be used for externally controlled release of ...

  16. The Intravenous Route to Blood Glucose Control

    E-Print Network [OSTI]

    Peppas, Nicholas A.

    or continuous infusion of insulin. A review of these methods of blood glucose control by Cobelli, et al elevated glucose concentrations in the early morning hours. The continuous infusion insulin pump allows

  17. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Physical Activity and Your Heart benefits. It can strengthen your heart and improve lung func- tion, and it may help prevent certain types

  18. Plasmacytoid Dendritic Cells Capture and Cross-Present Viral Antigens from Influenza-Virus Exposed Cells

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , France Abstract Among the different subsets of dendritic cells (DC), plasmacytoid dendritic cells (PDC, with human primary blood PDC and with a PDC cell line, that PDC display poor endocytic capacity for soluble or cellular antigens when compared to monocyte-derived myeloid DC. However, immature PDC efficiently take up

  19. Crystallographic study of red fluorescent protein eqFP578 and its far-red variant

    E-Print Network [OSTI]

    cause lesser damage to cells. The most favorable ``optical window'' for the visualization in living, Frederick, Maryland 21702 4 Synchrotron Radiation Research Section, Macromolecular Crystallography of FPs in cell biology, biotech- nology, and biomedical studies enabled optical imag- ing of gene

  20. Current Transients in CdS/CdTe Solar Cells Alan Fahrenbruch

    E-Print Network [OSTI]

    Sites, James R.

    a red (630 nm) LED with an output equivalent to 1 sun for light data. Red (630 nm) and blue (470 nmCurrent Transients in CdS/CdTe Solar Cells Alan Fahrenbruch Colorado State University Department is completely reversible, with a decay to the DS state. The current/time data were taken using an HP 7090A A

  1. Red phosphors for use in high CRI fluorescent lamps

    DOE Patents [OSTI]

    Srivastava, Alok; Comanzo, Holly; Manivannan, Vankatesan; Setlur, Anant Achyut

    2005-11-15T23:59:59.000Z

    Novel red emitting phosphors for use in fluorescent lamps resulting in superior color rendering index values compared to conventional red phosphors. Also disclosed is a fluorescent lamp including a phosphor layer comprising blends of one or more of a blue phosphor, a blue-green phosphor, a green phosphor and a red a phosphor selected from the group consisting of SrY.sub.2 O.sub.4 :Eu.sup.3+, (Y,Gd)Al.sub.3 B.sub.4 O.sub.12 :Eu.sup.3+, and [(Y.sub.1-x-y-m La.sub.y)Gd.sub.x ]BO.sub.3 :Eu.sub.m wherein y<0.50 and m=0.001-0.3. The phosphor layer can optionally include an additional deep red phosphor and a yellow emitting phosphor. The resulting lamp will exhibit a white light having a color rendering index of 90 or higher with a correlated color temperature of from 2500 to 10000 Kelvin. The use of the disclosed red phosphors in phosphor blends of lamps results in high CRI light sources with increased stability and acceptable lumen maintenance over the course of the lamp life.

  2. Ages of White Dwarf-Red Subdwarf Systems

    E-Print Network [OSTI]

    Hektor Monteiro; Wei-Chun Jao; Todd Henry; John Subasavage; Thom Beaulieu

    2005-10-12T23:59:59.000Z

    We provide the first age estimates for two recently discovered white dwarf-red subdwarf systems, LHS 193AB and LHS 300AB. These unusual systems provide a new opportunity for linking the reliable age estimates for the white dwarfs to the (measurable) metallicities of the red subdwarfs. We have obtained precise photometry in the $V_{J}R_{KC}I_{KC}JH$ bands and spectroscopy covering from 6000\\AA to 9000\\AA for the two new systems, as well as for a comparison white dwarf-main sequence red dwarf system, GJ 283 AB. Using model grids available in the literature, we estimate the cooling age as well as temperature, surface gravity, mass, progenitor mass and {\\it total} lifetimes of the white dwarfs. The results indicate that the two new systems are probably ancient thick disk objects with ages of at least 6-9 Gyr. We also conduct searches of red dwarf and white dwarf compendia from SDSS data and the L{\\'e}pine Shara Proper Motion (LSPM) catalog for additional common proper motion white dwarf-red subdwarf systems. Only seven new candidate systems are found, which indicates the rarity of these systems.

  3. Blood storage device and method for oxygen removal

    DOE Patents [OSTI]

    Bitensky, Mark W. (Waban, MA); Yoshida, Tatsuro (Newton, MA)

    2000-01-01T23:59:59.000Z

    The present invention relates to a storage device and method for the long-term storage of blood and, more particularly, to a blood storage device and method capable of removing oxygen from the stored blood and thereby prolonging the storage life of the deoxygenated blood.

  4. The Centre for Blood Research Dr. Tanya Petraszko

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Dr. Tanya Petraszko Medical Consultant Canadian Blood Services At Canadian Blood Services" This Seminar is sponsored by: Refreshments will be served 10 minutes before followed by some provincial statistics on blood distribution and utilization. Time permitting we may

  5. Magnetic particle imaging of blood coagulation

    SciTech Connect (OSTI)

    Murase, Kenya, E-mail: murase@sahs.med.osaka-u.ac.jp; Song, Ruixiao; Hiratsuka, Samu [Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, Osaka 565-0871 (Japan)

    2014-06-23T23:59:59.000Z

    We investigated the feasibility of visualizing blood coagulation using a system for magnetic particle imaging (MPI). A magnetic field-free line is generated using two opposing neodymium magnets and transverse images are reconstructed from the third-harmonic signals received by a gradiometer coil, using the maximum likelihood-expectation maximization algorithm. Our MPI system was used to image the blood coagulation induced by adding CaCl{sub 2} to whole sheep blood mixed with magnetic nanoparticles (MNPs). The “MPI value” was defined as the pixel value of the transverse image reconstructed from the third-harmonic signals. MPI values were significantly smaller for coagulated blood samples than those without coagulation. We confirmed the rationale of these results by calculating the third-harmonic signals for the measured viscosities of samples, with an assumption that the magnetization and particle size distribution of MNPs obey the Langevin equation and log-normal distribution, respectively. We concluded that MPI can be useful for visualizing blood coagulation.

  6. Reliable noninvasive measurement of blood gases

    DOE Patents [OSTI]

    Thomas, Edward V. (Albuquerque, NM); Robinson, Mark R. (Albuquerque, NM); Haaland, David M. (Albuquerque, NM); Alam, Mary K. (Albuquerque, NM)

    1994-01-01T23:59:59.000Z

    Methods and apparatus for, preferably, determining noninvasively and in vivo at least two of the five blood gas parameters (i.e., pH, PCO.sub.2, [HCO.sub.3.sup.- ], PO.sub.2, and O.sub.2 sat.) in a human. The non-invasive method includes the steps of: generating light at three or more different wavelengths in the range of 500 nm to 2500 nm; irradiating blood containing tissue; measuring the intensities of the wavelengths emerging from the blood containing tissue to obtain a set of at least three spectral intensities v. wavelengths; and determining the unknown values of at least two of pH, [HCO.sub.3.sup.- ], PCO.sub.2 and a measure of oxygen concentration. The determined values are within the physiological ranges observed in blood containing tissue. The method also includes the steps of providing calibration samples, determining if the spectral intensities v. wavelengths from the tissue represents an outlier, and determining if any of the calibration samples represents an outlier. The determination of the unknown values is performed by at least one multivariate algorithm using two or more variables and at least one calibration model. Preferably, there is a separate calibration for each blood gas parameter being determined. The method can be utilized in a pulse mode and can also be used invasively. The apparatus includes a tissue positioning device, a source, at least one detector, electronics, a microprocessor, memory, and apparatus for indicating the determined values.

  7. nature medicine volume 18 | number 4 | april 2012 475 Microfluidic chips promise better diagnosis for sickle cell disease

    E-Print Network [OSTI]

    Bhatia, Sangeeta

    for signs of the debilitating blood disease sickle cell anemia. Existing blood tests can accurately diagnose diagnosis for sickle cell disease As part of routine newborn screening programs, babies are checked predict the likelihood of clot formation, a dangerous complication of sickle cell disease. In one design

  8. Varieties of Cotton in the Red Prairies of Northwest Texas.

    E-Print Network [OSTI]

    Quinby, John Roy

    1927-01-01T23:59:59.000Z

    . NORTHCUTT. JR., B. S.. Feed Inspedor SIDNEY D. REYNOLDS. JR.. Feed Inspector P. A. MOORE, Feed Inspector SUBSTATIONS No. 1 Beerille, Bee County: R. A. HALL, B. S.. Superintendent o. 10. Ftsdfng and Breeding Station. near College Station. Brazos Connty... OF COTTON IN THE RED PRAIRIES OF NORTH- WEST TEXAS Substation No. 12 of the Texas Agricultural Experiment Station is located in the eastern part of Hardeman County southwest of Chilli- cothe about midway between the Red and Pease Rivers, and in the seo...

  9. Improving the Infra-red of Holographic Descriptions of QCD

    E-Print Network [OSTI]

    Nick Evans; Andrew Tedder; Tom Waterson

    2007-01-03T23:59:59.000Z

    A surprisingly good holographic description of QCD can be obtained from naive five dimensional gauge theory on a truncated AdS space. We seek to improve the infra-red description of QCD in such models by using a more sophisticated metric and an action derived from string theory duals of chiral symmetry breaking. Our metric is smooth into the infra-red and the chiral condensate is a prediction of the dynamics. The theory reproduces QCD meson data at the 10% level.

  10. RedShift Systems Corporation | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt Ltd Jump to: navigation, searchRay County,OpenCounty, Texas:Red RiverRedShift

  11. Blood Gas, Oxygen Saturation, pH, and Lactate Values in Elasmobranch Blood Measured with a Commercially Available

    E-Print Network [OSTI]

    Miami, University of

    Blood Gas, Oxygen Saturation, pH, and Lactate Values in Elasmobranch Blood Measured Research Laboratory, New England Aquarium, Central Wharf, Boston, Massachusetts 02110, USA Abstract.--Blood often be most valuable when blood samples are analyzed immediately after collection. Portable clinical

  12. ENVIRONMENTAL ASSESSMENT DOE/EA-0821 FOR THE OPERATION OF THE...

    Broader source: Energy.gov (indexed) [DOE]

    square inch Point-Plume plutonium public law potency factor or unit cancer risk Regional Air Pollution Control Agency red blood cells Resource Conservation and Recovery Act...

  13. New red phosphor for near-ultraviolet light-emitting diodes with high color-purity

    SciTech Connect (OSTI)

    Wang, Zhengliang, E-mail: wzhl_ww@yahoo.com.cn [School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming, Yunnan 650031 (China)] [School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming, Yunnan 650031 (China); He, Pei; Wang, Rui [School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510275 (China)] [School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510275 (China); Zhao, Jishou [School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming, Yunnan 650031 (China)] [School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming, Yunnan 650031 (China); Gong, Menglian [School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510275 (China)] [School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510275 (China)

    2010-02-15T23:59:59.000Z

    New red phosphors, Na{sub 5}Eu(MoO{sub 4}){sub 4} doped with boron oxide were prepared by the solid-state reaction. Their structure and photo-luminescent properties were investigated. With the introduction of boron oxide, the red emission intensity of the phosphors under 395 nm excitation is strengthened, with high color-purity (x = 0.673, y = 0.327). The single red light-emitting diode was obtained by combining InGaN chip with the red phosphor, bright red light can be observed by naked eyes from the red light-emitting diodes under a forward bias of 20 mA.

  14. Method for measuring lead concentrations in blood

    DOE Patents [OSTI]

    Nogar, Nicholas S. (Los Alamos, NM)

    2001-01-01T23:59:59.000Z

    Method for measuring lead concentrations in blood. The present invention includes the use of resonant laser ablation to analyze .ltoreq.1 .mu.L (or equivalent mass) samples of blood for lead content. A typical finger prick, for example, yields about 10 .mu.L. Solid samples may also readily be analyzed by resonant laser ablation. The sample is placed on a lead-free, electrically conducting substrate and irradiated with a single, focused laser beam which simultaneously vaporizes, atomizes, and resonantly ionizes an analyte of interest in a sample. The ions are then sorted, collected and detected using a mass spectrometer.

  15. A few nascent methods for measuring mechanical properties of the biological cell.

    SciTech Connect (OSTI)

    Thayer, Gayle Echo; de Boer, Maarten Pieter; Corvalan, Carlos (Purdue University, West Lafayette, IN); Corwin, Alex David; Campanella, Osvaldo H. (Purdue University, West Lafayette, IN); Nivens, David (Purdue University, West Lafayette, IN); Werely, Steven (Purdue University, West Lafayette, IN); Sumali, Anton Hartono; Koch, Steven John

    2006-01-01T23:59:59.000Z

    This report summarizes a survey of several new methods for obtaining mechanical and rheological properties of single biological cells, in particular: (1) The use of laser Doppler vibrometry (LDV) to measure the natural vibrations of certain cells. (2) The development of a novel micro-electro-mechanical system (MEMS) for obtaining high-resolution force-displacement curves. (3) The use of the atomic force microscope (AFM) for cell imaging. (4) The adaptation of a novel squeezing-flow technique to micro-scale measurement. The LDV technique was used to investigate the recent finding reported by others that the membranes of certain biological cells vibrate naturally, and that the vibration can be detected clearly with recent instrumentation. The LDV has been reported to detect motions of certain biological cells indirectly through the motion of a probe. In this project, trials on Saccharomyces cerevisiae tested and rejected the hypothesis that the LDV could measure vibrations of the cell membranes directly. The MEMS investigated in the second technique is a polysilicon surface-micromachined force sensor that is able to measure forces to a few pN in both air and water. The simple device consists of compliant springs with force constants as low as 0.3 milliN/m and Moire patterns for nanometer-scale optical displacement measurement. Fields from an electromagnet created forces on magnetic micro beads glued to the force sensors. These forces were measured and agreed well with finite element prediction. It was demonstrated that the force sensor was fully functional when immersed in aqueous buffer. These results show the force sensors can be useful for calibrating magnetic forces on magnetic beads and also for direct measurement of biophysical forces on-chip. The use of atomic force microscopy (AFM) for profiling the geometry of red blood cells was the third technique investigated here. An important finding was that the method commonly used for attaching the cells to a substrate actually modified the mechanical properties of the cell membrane. Thus, the use of the method for measuring the mechanical properties of the cell may not be completely appropriate without significant modifications. The latest of the studies discussed in this report is intended to overcome the drawback of the AFM as a means of measuring mechanical and rheological properties. The squeezing-flow AFM technique utilizes two parallel plates, one stationary and the other attached to an AFM probe. Instead of using static force-displacement curves, the technique takes advantage of frequency response functions from force to velocity. The technique appears to be quite promising for obtaining dynamic properties. More research is required to develop this technique.

  16. Microfluidic Platforms for Capturing Circulating Tumor Cells

    E-Print Network [OSTI]

    Tang, William C

    Microfluidic Platforms for Capturing Circulating Tumor Cells Sweta Gupta, Allison C. Baker-cost microfluidic device that can be used to isolate and capture circulating tumor cells (CTCs) from whole blood. The device was made from polydimethylsiloxane (PDMS) consisting of a microfluidic channel with microposts

  17. Deciphering a Kit-Shp2-Kit axis in regulation of adult hematopoietic stem and progenitor cells

    E-Print Network [OSTI]

    Zhu, He

    2011-01-01T23:59:59.000Z

    leukemogenesis in childhood acute leukemia. Blood 104, 307-syndromes and acute myeloid leukemia. Nat Genet 34, 148-150.proliferation in acute myeloblastic leukemia cell lines. J

  18. InsideBauer RED Labs: Start Me Up

    E-Print Network [OSTI]

    Azevedo, Ricardo

    : Lithuania 38 Bauer Recognized for Exemplary Internal Audit Program 41 RED Labs: Start Me Up 42 A Unique Adrenaline Rush 62 Cover: The Changing Landscape of Higher Education 64 A Whole New Venture 68 Energy Lecture Opens Doors 72 Bauer's Sales Excellence Institute Named Top University Sales Program 73 Our

  19. Resource Stewardship Tips for 2012 Recreational Red Snapper Season

    E-Print Network [OSTI]

    Watson, Craig A.

    trying to catch a bigger fish may have unintended consequences when water temperatures approach the mid creating a thermocline. The result is temperature shock and possibly death for the fish which remains rebuild and are reflected by the numerous large fish landed. Red Snapper dominate many Gulf of Mexico

  20. Alcian Blue Alizarin Red Skeletal Staining October 2003

    E-Print Network [OSTI]

    De Robertis, Eddy M.

    Alcian Blue ­ Alizarin Red Skeletal Staining October 2003 Eddy M. De Robertis 1. Dissect mice damage. 3. Replace 95% ethanol with Alcian blue staining solution for 1-3 days slowly rocking at room days. 4. Replace Alcian blue solution with 95% ethanol for 6 hours slowly rocking at room temperature

  1. HISTORY OF RED LAKES FISHERY, With Observations on

    E-Print Network [OSTI]

    was presented of the artificial propagation of the walleye and whitefish from 1918 through 1938. NOTE Average catch per lift 20 The walleyes of Lower Red Lake 25 Length -frequency distributions 25 Rate bass 50 Artificial propagation 50 Walleye 51 Whitefish 57 Brook, brown, rainbow, and lake trout 60

  2. The Hermeneutics and Genesis of the Red Cow Ritual

    E-Print Network [OSTI]

    MacDonald, Nathan

    2012-07-11T23:59:59.000Z

    HTR 105:3 (2012) 351–71 The Hermeneutics and Genesis of the Red Cow Ritual* Nathan MacDonald University of Göttingen / University of St. Andrews Q#3;Introduction 7KH#3;GLIÀFXOWLHV#3;ZLWK#3;WKH#3;UHG#3;FRZ#3;ULWXDO#3;KDYH#3;ORQJ#3;H[HUFLVHG#3;UHDGHUV...

  3. Thermo Exam 1 pg 1 Fall 2010 RED barcode here

    E-Print Network [OSTI]

    Hart, Gus

    Thermo Exam 1 ­ pg 1 Fall 2010 RED barcode here Physics 123 section 2 Exam 1 Colton 2-3669 Please otherwise instructed, give all numerical answers for the worked problems in SI units, to 3 or 4 significant not get this test booklet back. #12;Thermo Exam 1 ­ pg 2 (15 pts) Problem 1: Multiple choice conceptual

  4. Thermo Exam 2 pg 1 Fall 2010 RED barcode here

    E-Print Network [OSTI]

    Hart, Gus

    Thermo Exam 2 ­ pg 1 Fall 2010 RED barcode here Physics 123 section 2 Exam 2 Colton 2-3669 Please in SI units, to 3 or 4 significant digits. For answers that rely on intermediate results, remember to write down your CID at the top of the page? _________ #12;Thermo Exam 1 ­ pg 2 (15 pts) Problem 1

  5. ORIGINAL PAPER Responses of red deer (Cervus elaphus) to regular

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ORIGINAL PAPER Responses of red deer (Cervus elaphus) to regular disturbance by hill walkers Angela calving rates in elk Cervus elaphus canadensis have been linked to human disturbance (Philips-recognised that the effect of disturbance can vary with its predictability; unexpected events, such as hill walkers

  6. INTEGRATED LIDAR & PHOTOGRAMMETRIC DOCUMENTATION OF THE RED GULCH DINOSAUR

    E-Print Network [OSTI]

    Falkingham, Peter

    101 INTEGRATED LIDAR & PHOTOGRAMMETRIC DOCUMENTATION OF THE RED GULCH DINOSAUR TRACKSITE (WYOMING Resource Technology Section, National Operations Center, Bu- reau of Land Management, Bldg. 50 Denver, CO of successful schemes is testament to the advances made in attitudes and approaches to fossil site management

  7. The Centre for Blood Research Seminar Series

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Seminar Series Wednesday, July 17th, 2013 LSC 3 - Life Sciences. The latter represents challenges in regard to cost, safety, ecological friendliness, and process equipment that including >50 mM salts such as NaCitrate with 8 to 10% (w/w) solutions of PAA allowed for almost complete

  8. American Heart Month National High Blood

    E-Print Network [OSTI]

    FEBRUARY American Heart Month MAY National High Blood Pressure Education Month SEPTEMBER National Cholesterol Education Month Texas AgriLife Extension Service Texas A&M University System Eat Smart for Heart-1 Eat Smart for Heart Health - Cholesterol/Saturated Fat # P3-2 Cardiovascular Disease Statistics # P3

  9. American Heart Month National High Blood

    E-Print Network [OSTI]

    FEBRUARY American Heart Month MAY National High Blood Pressure Education Month SEPTEMBER National Cholesterol Education Month Texas AgriLife Extension Service Texas A&M University System Eat Smart for Heart Health Heart Health - Lesson 1 Contents: Lesson - Heart Health Power Point # P1-1 Eat Smart for Heart

  10. Reliable noninvasive measurement of blood gases

    DOE Patents [OSTI]

    Thomas, Edward V. (Albuquerque, NM); Robinson, Mark R. (Albuquerque, NM); Haaland, David M. (Albuquerque, NM); Alam, Mary K. (Cedar Crest, NM)

    1997-05-20T23:59:59.000Z

    This invention relates to methods and apparatus for, preferably, determining non-invasively and in vivo at least two of the five blood gas parameters (i.e., pH, [HCO.sub.3.sup.- ], PCO.sub.2, PO.sub.2, and O.sub.2 sat.) in a human.

  11. National Heart, Lung, and Blood Institute

    E-Print Network [OSTI]

    Bandettini, Peter A.

    National Heart, Lung, and Blood Institute A T - A - G L A N C E : Asthma A sthma is a chronic (longterm) lung dis ease that inflames and narrows the air ways. This makes the airways swollen and very, the muscles around them tighten. This causes the airways to nar row, and less air flows to your lungs

  12. Increased Blood Glucose is Related to Disturbed Cerebrovascular Pressure Reactivity After Traumatic Brain Injury

    E-Print Network [OSTI]

    Donnelly, Joseph; Sudhan, Nazneen; Varsos, Georgios V.; Nasr, Nathalie; Jalloh, Ibrahim; Liu, Xiuyun; Dias, Celeste; Sekhon, Mypinder; Carpenter, Keri L. H.; Menon, David K.; Hutchinson, Peter J.; Smielewski, Peter; Czosnyka, Marek

    2014-08-15T23:59:59.000Z

    of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada 6 Institute of Electronic Systems, Warsaw University of Technology, Warsaw, Poland Running title: Glucose and pressure reactivity after traumatic... acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology. J Cereb Blood Flow Metab 1981;1:297–311. 7. Diaz-Parejo P, Ståhl N, Xu W, Reinstrup P, Ungerstedt U, Nordström C-H. Cerebral energy metabolism during transient hyperglycemia...

  13. Method and device for supporting blood vessels during anastomosis

    DOE Patents [OSTI]

    Doss, J.D.

    1985-05-20T23:59:59.000Z

    A device and method for preventing first and second severed blood vessels from collapsing during attachment to each other. The device comprises a dissolvable non-toxic stent that is sufficiently rigid to prevent the blood vessels from collapsing during anastomosis. The stent can be hollow or have passages to permit blood flow before it dissolves. A single stent can be inserted with an end in each of the two blood vessels or separate stents can be inserted into each blood vessel. The stent may include a therapeutically effective amount of a drug which is slowly released into the blood stream as the stent dissolves. 12 figs.

  14. Evaluation of Critical Habitat for the California red-legged frog (Rana aurora draytonii)

    E-Print Network [OSTI]

    Allen, Michael F.; Tennant, Tracy

    2000-01-01T23:59:59.000Z

    With Comparisons to Rana Aurora and Rana Pretiosa. ” Copeia.M. Jennings. May 1996. “Rana aurora- Red -legged Frog” [WebRed- Legged Frog, Rana aurora, Tadpoles. ” Animal Behaviour

  15. adjustable red-green-blue led: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    or by combining green and red phosphors on a background consisting of a blue-light emitting diode (LED) or by employing nanocrystals (NCs) of the three primary colors (red,...

  16. Aerosol effects on red blue ratio of clear sky images, and impact on solar forecasting

    E-Print Network [OSTI]

    Ghonima, Mohamed Sherif

    2011-01-01T23:59:59.000Z

    DIEGO Aerosol effects on Red Blue Ratio of Clear Sky Images,decision image (green: cloudy, blue: clear). The figure wasAerosol effects on Red Blue Ratio of Clear Sky Images, and

  17. Evaluation of various sulphur amino acid compounds in the diet of red drum, Sciaenops ocellatus

    E-Print Network [OSTI]

    Goff, Jonathan B

    2003-01-01T23:59:59.000Z

    Refinement of diet formulations to enhance the efficiency of red drum production continues to be pursued. Based on previous studies, the sulfur amino acid (SAA) requirement of red drum for methionine plus cystine appears to be most limiting, which...

  18. Adaptive Tuning of RED Using On-line Simulation Tao Ye, Shivkumar Kalyanaraman

    E-Print Network [OSTI]

    Kalyanaraman, Shivkumar

    on the proposed RED optimization scheme, a general automatic network management system, i.e., on-line simulation

  19. Noninvasive Monitoring of MurineTumor Blood Flow During and After PhotodynamicTherapy Provides EarlyAssessment of

    E-Print Network [OSTI]

    Yodh, Arjun G.

    that localizes in tumor tissue and is subsequently activated by exposure to optical radiation. The photo (DCS) was used to measure blood flow continuously in radiation-induced fibrosarcoma murine tumors cause necrosis and apoptosis of cells (2), activation of the host immune system (3), and vascular damage

  20. "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2

    E-Print Network [OSTI]

    Watson, Craig A.

    VM85 "Red Sore Disease"in Game Fish1 Peggy Reed and Ruth Francis-Floyd2 1. This document is VM85 fish is generically referred to as "red sore disease." This problem usually occurs in the spring on their fish. Typically, "red sore disease" is caused by two organisms, Aeromonas hydrophila , a bacterium

  1. Understanding Blue-to-Red Conversion in Monomeric Fluorescent Timers and Hydrolytic Degradation of Their

    E-Print Network [OSTI]

    Verkhusha, Vladislav V.

    Understanding Blue-to-Red Conversion in Monomeric Fluorescent Timers and Hydrolytic Degradation-FT (chromophore Met66-Tyr67-Gly68) and its precursor with blocked blue-to- red conversion Blue102 (chromophore Leu data suggest that blue-to-red conversion, taking place in Fast-FT and in related FTs, is associated

  2. Constraints on origin and evolution of Red Sea brines from helium and argon isotopes

    E-Print Network [OSTI]

    Winckler, Gisela

    Constraints on origin and evolution of Red Sea brines from helium and argon isotopes Gisela November 2000 Abstract Brines from three depressions along the axis of the Red Sea, the Atlantis II II and the Discovery brines originating from locations in the central Red Sea show 4 He

  3. Red Algae Lose Key Mitochondrial Genes in Response to Becoming Parasitic

    E-Print Network [OSTI]

    Lane, Chris

    Red Algae Lose Key Mitochondrial Genes in Response to Becoming Parasitic Lillian Hancock1 , Lynda independently evolved hundreds of times among the floridiophyte red algae. Much is known about the life history class of red algae, Plocamiocolax puvinata, has lost the atp8 gene entirely, indicating that this gene

  4. Evolutionary Ecology, 1987, 1, 59-94 Red Queens and ESS

    E-Print Network [OSTI]

    Brown, Joel S.

    Evolutionary Ecology, 1987, 1, 59-94 Red Queens and ESS: the coevolution of evolutionary rates coevolutionary rates of zero is that of evolutio- narily stable strategies (ESS). Red Queen assumes that the more of such a phenotypic trait value. Such traits are the key to the Red Queen prediction of progressive coevolution. ESS

  5. Upper Middle Mainstem Columbia River Subbasin Focal Species Information, Red-winged Blackbird

    E-Print Network [OSTI]

    Appendix C Upper Middle Mainstem Columbia River Subbasin Focal Species Information, Red-winged Blackbird Introduction The red-winged black bird is one of the most abundant birds in North America (Marshall et al. 2003). Red-winged Blackbirds are extremely adaptable; successfully colonizing many small

  6. Alternate Explosions: Collapse and Accretion Events with Red Holes instead of Black Holes

    E-Print Network [OSTI]

    James S. Graber

    1999-08-10T23:59:59.000Z

    A red hole is "just like a black hole" except it lacks an event horizon and a singularity. As a result, a red hole emits much more energy than a black hole during a collapse or accretion event. We consider how a red hole solution can solve the "energy crisis" and power extremely energetic gamma ray bursts and hypernovae.

  7. Original article Differences between blood and plasma concentrations

    E-Print Network [OSTI]

    Boyer, Edmond

    porte / ruminant / sang / plasma 1. INTRODUCTION Many studies in ruminant nutrition focus- ies have already focused on differences between blood and plasma concentrations of various metabolitesOriginal article Differences between blood and plasma concentrations of acetate, &beta

  8. abo blood incompatibility: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Behra Rajshree; Joshi Yogi Raj 4 ABO, D Blood Typing and Subtyping Using Plug-Based Microfluidics Chemistry Websites Summary: ABO, D Blood Typing and Subtyping Using Plug-Based...

  9. abo blood system: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Behra Rajshree; Joshi Yogi Raj 2 ABO, D Blood Typing and Subtyping Using Plug-Based Microfluidics Chemistry Websites Summary: ABO, D Blood Typing and Subtyping Using Plug-Based...

  10. automated blood bank: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Blood Banking in Living Droplets MIT - DSpace Summary: Blood banking has a broad public health impact...

  11. activates human blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    o Reinfuse the patient's blood slowly, no faster than 1mL per second, by pressing the plunger back Kay, Mark A. 451 Blood monocytes consist of two principal subsets with...

  12. ankle blood pressure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    o Reinfuse the patient's blood slowly, no faster than 1mL per second, by pressing the plunger back Kay, Mark A. 304 Modeling of Pulsatile Blood flow in a weak magnetic field...

  13. automated blood pressure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    o Reinfuse the patient's blood slowly, no faster than 1mL per second, by pressing the plunger back Kay, Mark A. 334 Modeling of Pulsatile Blood flow in a weak magnetic field...

  14. adult blood pressure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    o Reinfuse the patient's blood slowly, no faster than 1mL per second, by pressing the plunger back Kay, Mark A. 197 Modeling of Pulsatile Blood flow in a weak magnetic field...

  15. Blood oxygen transport and depletion : the key of consummate divers

    E-Print Network [OSTI]

    Meir, Jessica Ulrika

    2009-01-01T23:59:59.000Z

    and Dill, D. B. (1935). Oxygen dissociation curves of birdE. (1964). A venous blood oxygen reservoir in the divingand Torrance, J. D. (1977). Oxygen-Affinity of Avian Blood.

  16. Blood markers for the diagnosis and prognosis of stroke 

    E-Print Network [OSTI]

    Whiteley, William Nichol

    2011-07-05T23:59:59.000Z

    Many blood markers have been associated with stroke. I set out to determine whether blood markers can be applied to: (i) improve the accuracy of the clinical diagnosis of stroke or TIA, and/or (ii) improve the prediction ...

  17. Cholecystokinin Protects Pancreatic Beta-Cells From Stress-Induced Cell Death

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    were immunostained for DAPI (blue) and insulin (red). Quantitative analysis demonstrated increased). Quantitative analysis (E) reveals reduced beta-cell death in MIP-CCK mice on day 8. Funding Acknowledgements UW population at increased risk for type 2 diabetes. · Cholecystokinin (CCK) is a gut hormone released

  18. The growth of luminous red galaxies by merging

    E-Print Network [OSTI]

    Morad Masjedi; David W. Hogg; Michael R. Blanton

    2007-08-23T23:59:59.000Z

    We study the role of major and minor mergers in the mass growth of luminous red galaxies. We present small-scale ($0.01luminous early-type galaxies from the Sloan Digital Sky Survey (SDSS) Luminous Red Galaxy (LRG) sample ($0.16luminous than $\\Lstar$. We integrate the luminosity accretion rate from mergers over all companion galaxy subsamples and find that LRGs are growing by $[1.7\\pm 0.1]$ percent per $\\Gyr$, on average, from merger activity at redshift $z\\sim 0.25$. This rate is almost certainly an over-estimate because we have assumed that all close pairs are merging as quickly as dynamical friction allows; nonetheless it is on the low side of the panoply of measurements in the literature, and lower than any rate predicted from theory.

  19. Eleccion simulador de red 4 de mayo de 2012

    E-Print Network [OSTI]

    Elecci´on simulador de red 4 de mayo de 2012 La simulaci´on es una herramienta poderosa para el an representativos mediante simulaciones no es una tarea sencilla. Hay dos aspectos claves que se deben evaluar antes de la realizaci´on de las simulaciones: Una es la utilizaci´on del modelo correcto. La simulaci´on de

  20. Chemistry & Biology Hemoglobin Digestion in Blood-Feeding Ticks

    E-Print Network [OSTI]

    Bogyo, Matthew

    Chemistry & Biology Article Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase: mares@uochb.cas.cz DOI 10.1016/j.chembiol.2009.09.009 SUMMARY Hemoglobin digestion is an essential transmission is linked to the physiology of blood feeding and digestion. Blood provides a rich source

  1. The Centre for Blood Research Dr. Scott Tebbutt

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Dr. Scott Tebbutt Associate Professor, UBC Chief Scientific Officer, October 3, 2012 12:00 pm in LSC3 Life Sciences Centre 2350 Health Sciences Mall "Blood-based signatures, CBR Director, Professor of Medicine, UBC Peripheral whole blood is often the sample of choice

  2. RETINAL BLOOD VESSEL SEGMENTATION USING GEODESIC VOTING METHODS Youssef Rouchdy

    E-Print Network [OSTI]

    Cohen, Laurent

    RETINAL BLOOD VESSEL SEGMENTATION USING GEODESIC VOTING METHODS Youssef Rouchdy and Laurent D to segment retinal blood vessels are presented. Many authors have used minimal cost paths, or similarly on the use of a set of such geodesic paths to extract retinal blood vessels, using minimal interaction

  3. Blood Impedance Characterization from Pulsatile Measurements School of Information Technology

    E-Print Network [OSTI]

    Adler, Andy

    Blood Impedance Characterization from Pulsatile Measurements Tao Dai School of Information of blood excluding the contributions from surround- ing tissues, based on analysis of the pulsatile MHz. The finger is modeled as three parts: arterial blood, surrounding tissues and incremental in

  4. Healthline.com New Sensor Screens Your Blood

    E-Print Network [OSTI]

    Bigelow, Stephen

    Healthline.com New Sensor Screens Your Blood for Drugs in Real-Time Written and illegal drugs in human blood. It's every doctor's dream--a small, wearable sensor that can monitor levels of, say, the heart drug digoxin in a patient's blood, and make sure that he or she gets

  5. Continuous Non-Invasive Blood-Pressure Measurements

    E-Print Network [OSTI]

    Campbell, Sarah J.

    Continuous Non-Invasive Blood-Pressure Measurements Tony Birch Chris Breward Sarah Campbell Igor, September 2007 Tony Birch et. al. Continuous Non-Invasive Blood-Pressure Measurements #12;Overview: Finapres. al. Continuous Non-Invasive Blood-Pressure Measurements #12;The Problem Under normal resting

  6. Keep the Beat: Control Your High Blood Pressure

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Keep the Beat: Control Your High Blood Pressure Healthy Hearts, Healthy Homes #12;Read other The NHLBI Information Center is a service of the National Heart, Lung, and Blood Institute (NHLBI, patients, and the public about the treatment, diagnosis, and prevention of heart, lung, and blood diseases

  7. Blood Drive Coordinator Packet Massachusetts General Hospital pg.2

    E-Print Network [OSTI]

    Mootha, Vamsi K.

    1 Blood Drive Coordinator Packet Massachusetts General Hospital pg.2 The MGH Bloodmobile pg.3 Facts about Blood Donation pg.4 Spreading the Word pg.5 Frequently Asked Questions and Tips pg.7 Schedule a Blood Drive pg.10 Eligibility Guidelines pg.11 #12;2 Massachusetts General Hospital

  8. Umbilical cord blood gas analysis at the time of

    E-Print Network [OSTI]

    Aickelin, Uwe

    Umbilical cord blood gas analysis at the time of delivery Maureen Harris, Sarah L. Beckley, Jonathan M. Garibaldi, Robert D. E Keith and Keith R. Greene Aims: it is now recommended that cord blood. In this paper our experience of cord blood analysis is described and the literature is reviewed to: (I) provide

  9. Large Blood Vessels 1.1 Introduction --The Cardiovascular System

    E-Print Network [OSTI]

    Luo, Xiaoyu

    Chapter 1 Large Blood Vessels 1.1 Introduction -- The Cardiovascular System The heart is a pump that circulates blood to the lungs for oxygenation (pul- monary circulation) and then throughout the systemic arterial system with a total cycle time of about one minute. From the left ventricle of the heart, blood

  10. Supply Chain Network Design of a Sustainable Blood Banking System

    E-Print Network [OSTI]

    Nagurney, Anna

    Supply Chain Network Design of a Sustainable Blood Banking System Anna Nagurney and Amir H. Masoumi a sustainable network design / redesign model for the complex supply chain of human blood, which is a valuable yet highly perish- able product. Specifically, we consider the optimal design (or redesign) of a blood

  11. FDA's MSM Blood Donation Policy: Did You Know??

    E-Print Network [OSTI]

    Khan, Javed I.

    FDA's MSM Blood Donation Policy: Did You Know?? Permanent ban on any male who has had sex NOT support the FDA's current MSM blood donation policy. The time it takes to test for HIV with the Nucleic, Japan, Italy, Spain, France and Sweden are countries that have all modified their blood donation

  12. Modeling Torsion of Blood Vessels in Surgical Simulation and Planning

    E-Print Network [OSTI]

    Leow, Wee Kheng

    Modeling Torsion of Blood Vessels in Surgical Simulation and Planning Hao LI a,1 , Wee Kheng LEOW a hybrid approach for modeling torsion of blood vessels that undergo deformation and joining. The proposed model takes 3D mesh of the blood vessel as input. It first fits a generalized cylinder to extract

  13. The Blood Transfusion Service Joel Umlas and Christopher P. Stowell

    E-Print Network [OSTI]

    Mootha, Vamsi K.

    319 Chapter The Blood Transfusion Service Joel Umlas and Christopher P. Stowell Transfusion in France using lamb's blood (1). A fourth patient died, apparently as a direct result of the procedure, which led to the banning of transfusions by the French Parliament (2). Blood banking, the stor- age

  14. The Centre for Blood Research Dr. Christian Kastrup

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Dr. Christian Kastrup Assistant Professor, Michael Smith Laboratories Centre 2350 Health Sciences Mall "Understanding and Controlling Blood Coagulation Using Models, Materials for Blood Research Having just begun my independent career at UBC, the purpose of this talk will be to give

  15. The Color of Blood: Between Sensory Experience and Epistemic Significance

    E-Print Network [OSTI]

    Bertoloni Meli, Domenico

    4 The Color of Blood: Between Sensory Experience and Epistemic Significance domenico bertoloni meli Si¯na¯-- known in the West as Avicenna--discussed the nature and composition of blood with regard to its role in nutrition. In an important passage, he argued that blood is a humor consisting of four

  16. Atrioventricular blood flow simulation based on patient-specific data

    E-Print Network [OSTI]

    Sussman, Mark

    Atrioventricular blood flow simulation based on patient-specific data Viorel Mihalef1 , Dimitris blood flow in- side the heart, usable with geometric models of the heart from patient- specific data. The method is geared toward realistic simulation of blood flow, taking into account not only heart wall

  17. Blood Flow Magnetic Resonance Imaging of Retinal Degeneration

    E-Print Network [OSTI]

    Duong, Timothy Q.

    Blood Flow Magnetic Resonance Imaging of Retinal Degeneration Yingxia Li,1 Haiying Cheng,1 Qiang. Duong1,2,3,4,5,6,7 PURPOSE. This study aims to investigate quantitative basal blood flow as well as hypercapnia- and hyperoxia-induced blood flow changes in the retinas of the Royal College of Surgeons (RCS

  18. Special Article Elucidating Nature's Solutions to Heart, Lung, and Blood

    E-Print Network [OSTI]

    Storz, Jay F.

    Special Article Elucidating Nature's Solutions to Heart, Lung, and Blood Diseases and Sleep defenses, and oxygen transport. In 2006, the National Heart, Lung, and Blood Institute released a funding understanding of nature's solutions to heart, lung, blood, and sleep disorders through future research

  19. Oxygen isotopic ratios in intermediate-mass red giants

    E-Print Network [OSTI]

    Lebzelter, Thomas; Hinkle, Kenneth; Nowotny, Walter; Aringer, Bernhard

    2015-01-01T23:59:59.000Z

    Context. The abundances of the three main isotopes of oxygen are altered in the course of the CNO-cycle. When the first dredge-up mixes the burning products to the surface, the nucleosynthesis processes can be probed by measuring oxygen isotopic ratios. Aims. By measuring 16O/17O and 16O/18O in red giants of known mass we compare the isotope ratios with predictions from stellar and galactic evolution modelling. Methods. Oxygen isotopic ratios were derived from the K-band spectra of six red giants. The sample red giants are open cluster members with known masses of between 1.8 and 4.5 Msun . The abundance determination employs synthetic spectra calculated with the COMARCS code. The effect of uncertainties in the nuclear reaction rates, the mixing length, and of a change in the initial abundance of the oxygen isotopes was determined by a set of nucleosynthesis and mixing models using the FUNS code. Results. The observed 16O/17O ratios are in good agreement with the model results, even if the measured values do ...

  20. Powered by 500 Trillion Calculations

    Broader source: Energy.gov [DOE]

    Argonne's supercomputer is using its superpowers to map the movement of red blood cells -- which will hopefully lead to better diagnoses and treatments for patients with blood flow complications.

  1. NaLaF{sub 4}:Pr{sup 3+},Yb{sup 3+}, an efficient blue to near infra-red quantum cutter

    SciTech Connect (OSTI)

    Guille, A.; Pereira, A.; Moine, B., E-mail: bernard.moine@univ-lyon1.fr [Université Lyon 1, CNRS UMR 5306, Institut Lumière Matière, Université de Lyon, F-69622 Villeurbanne (France)

    2013-12-01T23:59:59.000Z

    In order to reduce the thermalization losses in solar cells, down-conversion of blue photons into near infra-red photons is a promising solution. In the present paper, we analyse the energy transfer processes between Pr{sup 3+} and Yb{sup 3+} in NaLaF{sub 4} and we show that an efficient quantum-cutting process occurs. Nevertheless, we also show that a back transfer from Yb{sup 3+} toward the {sup 1}G{sub 4} level of Pr{sup 3+} ion leading to emission beyond 1??m reduces the potentiality of this material as a quantum cutter for Si solar cells.

  2. Application of Computational Physics: Blood Vessel Constrictions and Medical Infuses

    E-Print Network [OSTI]

    Suprijadi; Mohamad Rendi; Petrus Subekti; Sparisoma Viridi

    2013-12-14T23:59:59.000Z

    Application of computation in many fields are growing fast in last two decades. Increasing on computation performance helps researchers to understand natural phenomena in many fields of science and technology including in life sciences. Computational fluid dynamic is one of numerical methods which is very popular used to describe those phenomena. In this paper we propose moving particle semi-implicit (MPS) and molecular dynamics (MD) to describe different phenomena in blood vessel. The effect of increasing the blood pressure on vessel wall will be calculate using MD methods, while the two fluid blending dynamics will be discussed using MPS. Result from the first phenomenon shows that around 80% of constriction on blood vessel make blood vessel increase and will start to leak on vessel wall, while from the second phenomenon the result shows the visualization of two fluids mixture (drugs and blood) influenced by ratio of drugs debit to blood debit. Keywords: molecular dynamic, blood vessel, fluid dynamic, moving particle semi implicit.

  3. Application of Computational Physics: Blood Vessel Constrictions and Medical Infuses

    E-Print Network [OSTI]

    Suprijadi,; Subekti, Petrus; Viridi, Sparisoma

    2013-01-01T23:59:59.000Z

    Application of computation in many fields are growing fast in last two decades. Increasing on computation performance helps researchers to understand natural phenomena in many fields of science and technology including in life sciences. Computational fluid dynamic is one of numerical methods which is very popular used to describe those phenomena. In this paper we propose moving particle semi-implicit (MPS) and molecular dynamics (MD) to describe different phenomena in blood vessel. The effect of increasing the blood pressure on vessel wall will be calculate using MD methods, while the two fluid blending dynamics will be discussed using MPS. Result from the first phenomenon shows that around 80% of constriction on blood vessel make blood vessel increase and will start to leak on vessel wall, while from the second phenomenon the result shows the visualization of two fluids mixture (drugs and blood) influenced by ratio of drugs debit to blood debit. Keywords: molecular dynamic, blood vessel, fluid dynamic, movin...

  4. Computational and in vitro studies of blast-induced blood-brain barrier disruption

    E-Print Network [OSTI]

    Del Razo, Mauricio J; Meabon, James S; Huber, B Russell; Peskind, Elaine R; Banks, William A; Mourad, Pierre D; Leveque, Randall J; Cook, David G

    2015-01-01T23:59:59.000Z

    There is growing concern that blast-exposed individuals are at risk of developing neurological disorders later in life. Therefore, it is important to understand the dynamic properties of blast forces on brain cells, including the endothelial cells that maintain the blood-brain barrier (BBB), which regulates the passage of nutrients into the brain and protects it from toxins in the blood. To better understand the effect of shock waves on the BBB we have investigated an {\\em in vitro} model in which BBB endothelial cells are grown in transwell vessels and exposed in a shock tube, confirming that BBB integrity is directly related to shock wave intensity. It is difficult to directly measure the forces acting on these cells in the transwell container during the experiments, and so a computational tool has been developed and presented in this paper. Two-dimensional axisymmetric Euler equations with the Tammann equation of state were used to model the transwell materials, and a high-resolution finite volume method b...

  5. Inhibition of Photosynthesis in Some Algae by Extreme-Red Light Author(s): Eugene Rabinowitch, Govindjee, Jan B. Thomas

    E-Print Network [OSTI]

    Govindjee

    Inhibition of Photosynthesis in Some Algae by Extreme-Red Light Author(s): Eugene Rabinowitch://www.jstor.org #12;Inhibition of Photosynthesis in Some Algae by Extreme"Red Light Abstract. Photosynthesis produced by far-red light (about 700 m,b) is reversibly inhibited in some algae by extreme-red light ( 750 m

  6. Blood Pressure U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Your Blood Pressure Lowering Guide to U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute #12;Your Guide to Lowering Blood Pressure 2 What Are High Blood Pressure and Prehypertension? Blood pressure is the force of blood against

  7. Time-course correlation of biofilm properties and electrochemical performance in single-chamber microbial fuel cells

    E-Print Network [OSTI]

    Mench, Matthew M.

    -chamber microbial fuel cells Zhiyong Ren a,c , Ramaraja P. Ramasamy b,1 , Susan Red Cloud-Owen b , Hengjing Yan 2010 Keywords: Microbial fuel cell Electricity Biofilm Electrochemical impedance spectroscopy a b s t r in microbial fuel cells (MFCs) was analyzed by time-course sampling of parallel single-bottle MFCs operated

  8. Reference Sheet for Blood Culture Draws Blood Cultures are drawn to identify a pathogen that causes an infection such as sepsis, endocarditis, or a fever of

    E-Print Network [OSTI]

    Kim, Duck O.

    Reference Sheet for Blood Culture Draws Blood Cultures are drawn to identify a pathogen that causes in an effective and timely way the policy and procedure for obtaining the blood cultures must be followed which on each unit. Focus Fact Rationale Number of blood culture bottles A set of blood cultures = 2 bottles

  9. The Soils of Bowie, Denton, Freestone, and Red River Counties.

    E-Print Network [OSTI]

    Fraps, G. S. (George Stronach)

    1928-01-01T23:59:59.000Z

    (The *Fertilizer Green Book, December, 1922). The corn possibility is a convenient way of comparing amounts of various foods in the soil. For example, with the Bowie very fine sandy loam of Red River County, the corn possibility for active.... Thirty-four ty~es mere mapped, divided into seventeen series. A key to the classifi- cation of the soils is given below. The Susquehaniia very fine -sandy loam occupies 18.0 per cent of the county, the Bowie very fine sandy loam 11.5 per cent...

  10. The near-infra-red spectra of ferric acetylacetonate

    E-Print Network [OSTI]

    Owen, James Travis

    1965-01-01T23:59:59.000Z

    high, smooth output in the near-infra-red region. This source, Model IG-1(A), is a coiled Tungsten filament in a Quartz jacket, Its high output is maintained throughout its life by a small amount of iodine vapor, which effectively "cleaned..." the Quartz jacket of its layer of sputtered tungsten which would be expected to lower the Lumens-per-Hatt output of a normal tungsten source, No iodine spectrum was noted, but the output of the lamp does fall off a few hours before failure, A Quartz...

  11. Earth fissures of the Red Light Bolson, Hudspeth County, Texas

    E-Print Network [OSTI]

    Sherrier, Michael Perry

    1994-01-01T23:59:59.000Z

    in the laboratory techniques used during the soil analyses. Finally, I would like to thank the people of Sierra Blanca who went out of their way to make me feel welcome. A very special and heart-felt thanks goes to the family of R. Ramirez. The Ramirez household... in engineering design. Studies of the life history of individual or sets of fissures can lead to designing preemptive mitigation measures. Earth fissures are actively forming in the Red Light Bolson south of Sierra Blanca, Texas, the county seat of Hudspeth...

  12. MHK Technologies/RED HAWK | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal Pwer Plant Jump to:LandownersLuther, Oklahoma:EnergyECO Auger < MHK TechnologiesProteusRED

  13. The Spitzer Archival Far-InfraRed Extragalactic Survey

    E-Print Network [OSTI]

    Hanish, D; Teplitz, H; Desai, V; Armus, L; Brinkworth, C; Brooke, T; Colbert, J; Edwards, L; Fadda, D; Frayer, D; Huynh, M; Lacy, M; Murphy, E; Noriega-Crespo, A; Paladini, R; Scarlata, C; Shenoy, S

    2015-01-01T23:59:59.000Z

    We present the Spitzer Archival Far-InfraRed Extragalactic Survey (SAFIRES). This program produces refined mosaics and source lists for all far-infrared extragalactic data taken during the more than six years of the cryogenic operation of the Spitzer Space Telescope. The SAFIRES products consist of far-infrared data in two wavelength bands (70 um and 160 um) across approximately 180 square degrees of sky, with source lists containing far-infrared fluxes for almost 40,000 extragalactic point sources. Thus, SAFIRES provides a large, robust archival far-infrared data set suitable for many scientific goals.

  14. Overview of ''Red Oil'' Frequency Analyses for F-Canyon

    SciTech Connect (OSTI)

    Lux, C.R.

    2000-07-19T23:59:59.000Z

    A very small potential exists in the Savannah River Site (SRS) separations operations for an uncontrolled reaction between tri-n-butyl phosphate (TBP) and nitric acid that could result in unacceptable damage to separations facilities and a significant release of radioactive materials. The recent ''red oil'' (TBP and nitric acid) accident in Tomsk, Russia, resulted in considerable damage and radioactive release. Explosions have also occurred at SRS during the early years of operations. While the SRS separations facilities have operated without incident for many years, it is prudent to revisit the SRS defense-in-depth approach to preventing such an accident and to upgrade preventive procedures and hardware as appropriate.

  15. Red Bank, New Jersey: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-f < RAPID‎ | Roadmap Jump to:bJumpRed Bank, New Jersey: Energy

  16. Red Cliffs Campground, Cedar City District, Utah | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreakingMay 2015 < prevQuick Guide:U.N.June 8,Past OpportunitiesRed Cliffs

  17. City of Red Bud, Illinois (Utility Company) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof EnergyInnovationin UrbanCity of Okolona,Plummer, IdahoCity ofRed Bud, Illinois

  18. City of Red Cloud, Nebraska (Utility Company) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof EnergyInnovationin UrbanCity of Okolona,Plummer, IdahoCity ofRed Bud, IllinoisCity

  19. Town of Red Springs, North Carolina (Utility Company) | Open Energy

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit withTianlin Baxin Hydropower Station JumpOpenEITownTown ofTownInformation Red

  20. Red Bank, New Jersey: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt Ltd Jump to: navigation, searchRay County,Open EnergyRecent contentRecycledRed

  1. Red River Valley Rrl Elec Assn | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt Ltd Jump to: navigation, searchRay County,OpenCounty, Texas:Red River Valley

  2. Red Willow County, Nebraska: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt Ltd Jump to: navigation, searchRay County,OpenCounty, Texas:Red River

  3. City of Redding, California (Utility Company) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand JumpConceptual Model, clickInformation Smyrna Beach, FloridaCity ofCity of Rayne,Redding,

  4. Engineering functional blood vessels in vivo

    E-Print Network [OSTI]

    Au, Pakwai

    2008-01-01T23:59:59.000Z

    At the present time, there are many hurdles to overcome in order to create a long-lasting and engineered tissue for tissue transplant in patients. The challenges include the isolation and expansion of appropriate cells, ...

  5. Reversible harmless interruption of testicular blood supply in the ram

    SciTech Connect (OSTI)

    van Vliet, J.; De Ruiter-Bootsma, A.L.; Oei, Y.H.; Hoekstra, A.; De Rooij, D.G.; Wensing, C.J.

    1987-03-01T23:59:59.000Z

    An effective method of interrupting testicular blood flow temporarily and repeatedly in the ram has been developed. Blockade of flow has been achieved mechanically by an inflatable occluder placed around the testicular artery at the level of the spermatic cord. The effect of the blockade on total testicular blood supply was investigated using Doppler flowmetry and a percutaneous Xenon-133 injection method. With both approaches, the blood flow changes after inflation or deflation of the occluders could be estimated satisfactorily. A substantial decrease of testicular blood flow was achieved in eight of the 10 testes with inflated occluders. However, there were indications that in the remaining two testes blockade of the arterial flow was not complete. After deflation of the occluders, blood flow was restored rapidly and completely in all testes. Macro- and microscopic examinations revealed no long-term damage to the testis after blood flow interruptions lasting 30 or 60 minutes.

  6. APPLICATION OF THE THEORY OF INTERACTING CONTINUA TO BLOOD FLOW

    SciTech Connect (OSTI)

    Massoudi, Mehrdad; Kim, Jeongho; Hund, Samuel J.; Antaki, James F.

    2011-01-01T23:59:59.000Z

    Micro-scale investigations of the flow and deformation of blood and its formed elements have been studied for many years. Early in vitro investigations in the rotational viscometers or small glass tubes revealed important rheological properties such as the reduced blood apparent viscosity, Fahraeus effect and Fahraeus-Lindqvist effect [1], exhibiting the nonhomogeneous property of blood in microcirculation. We have applied Mixture Theory, also known as Theory of Interacting Continua, to study and model this property of blood [2, 3]. This approach holds great promise for predicting the trafficking of RBCs in micro-scale flows (such as the depletion layer near the wall), and other unique hemorheological phenomena relevant to blood trauma. The blood is assumed to be composed of an RBC component modeled as a nonlinear fluid, suspended in plasma, modeled as a linearly viscous fluid.

  7. Sedimentary processes of the Red River between Denison Dam, TX and Alexandria, LA

    E-Print Network [OSTI]

    Weirich, Thomas Moody - Kenyon

    1990-01-01T23:59:59.000Z

    Figure 1. Location map of study area along the Red River. . . . . . . . . . . . . 2 Figure 2. Location map of reach blocked by the natural raft. . . . . . . . . 12 Figure 3. Suspended sediment concentration and volumetric flow diagram. Figure 4... and sinuosity values between Temple, AR and Alexandria, LA. Table 3. Sinuosity values of the Red River course 1892, 1938, 1983. . 62 Table 4. Sieve analysis of alluvial flood plain samples. . . . . . . . . . . . . . . 76 INTRODUCTION The Red River...

  8. Compositional changes in red and violet smoke mixes after combustion

    SciTech Connect (OSTI)

    Buchanan, M.V.; Rubin, I.B.; Moneyhun, J.H.

    1983-01-01T23:59:59.000Z

    Anthraquinone-derived dyes are commonly used in colored dye mixes prepared for signal smoke grenades. Biological studies have shown, however, that a number of these dyes exhibit bacterial mutagenicity. In addition, these dyes are similar in structure to several polycyclic aromatic hydrocarbons which are well-known carcinogens. The grenades contain not only anthraquinone-derived dyes, but also a pyrotechnic fuel and cooling and starting mixes consisting primarily of potassium chlorate and nitrate, sodium bicarbonate, and sulfur. These dyes are volatilized at temperatures up to 550/sup 0/C during the detonation of the grenade, which could subject the dyes to oxidative and pyrolytic reactions that could result in a variety of reaction by-products. As part of a program to investigate possible environmental and occupational risks of the colored smoke dyes and in signal grenades, two colored smoke mixes, red and violet, have been studied both before and after detonation to evaluate any differences in composition due to the combustion process. This report focuses primarily on the separation and identification of the components of the original and combusted red and violet smoke mixes. The conditions for the detonation of the smoke grenades and sampling of the combusted smoke mixes are also discussed.

  9. Identification of Sites Within a Monomeric Red Fluorescent Protein that Tolerate Peptide Insertion and Testing of

    E-Print Network [OSTI]

    Campbell, Robert E.

    as dsFP583 and DsRed) has proven to be a particularly fruitful progenitor of variants with biochemical

  10. Red-white and blue baby: a case of phacomatosis pigmentovascularis type V

    E-Print Network [OSTI]

    Byrom, Lisa; Surjana, Devita; Yoong, Corinne; Zappala, Tania

    2015-01-01T23:59:59.000Z

    vignette Red-white and blue baby: a case of phacomatosisextensive greyish-blue patches (dermal melanocytosis)addition, marble-like reddish- blue patches consistent with

  11. Surface dust wipes are the best predictors of blood leads in young children with elevated blood lead levels

    SciTech Connect (OSTI)

    Gulson, Brian, E-mail: brian.gulson@mq.edu.au [Graduate School of the Environment, Macquarie University, North Ryde NSW 2109 (Australia) [Graduate School of the Environment, Macquarie University, North Ryde NSW 2109 (Australia); CSIRO Earth Science and Resource Engineering, North Ryde NSW 2113 (Australia); Anderson, Phil [Information and Statistics Group, Australian Institute of Health and Welfare, Canberra ACT 2601 (Australia) [Information and Statistics Group, Australian Institute of Health and Welfare, Canberra ACT 2601 (Australia); Faculty of Health, University of Canberra, Canberra ACT 2601 (Australia); Taylor, Alan [Department of Psychology, Macquarie University, Sydney NSW 2109 (Australia)] [Department of Psychology, Macquarie University, Sydney NSW 2109 (Australia)

    2013-10-15T23:59:59.000Z

    Background: As part of the only national survey of lead in Australian children, which was undertaken in 1996, lead isotopic and lead concentration measurements were obtained from children from 24 dwellings whose blood lead levels were ?15 µg/dL in an attempt to determine the source(s) of their elevated blood lead. Comparisons were made with data for six children with lower blood lead levels (<10 µg/dL). Methods: Thermal ionisation and isotope dilution mass spectrometry were used to determine high precision lead isotopic ratios ({sup 208}Pb/{sup 206}Pb, {sup 207}Pb/{sup 206}Pb and {sup 206}Pb/{sup 204}Pb) and lead concentrations in blood, dust from floor wipes, soil, drinking water and paint (where available). Evaluation of associations between blood and the environmental samples was based on the analysis of individual cases, and Pearson correlations and multiple regression analyses based on the whole dataset. Results and discussion: The correlations showed an association for isotopic ratios in blood and wipes (r=0.52, 95% CI 0.19–0.74), blood and soil (r=0.33, 95% CI ?0.05–0.62), and blood and paint (r=0.56, 95% CI 0.09–0.83). The regression analyses indicated that the only statistically significant relationship for blood isotopic ratios was with dust wipes (B=0.65, 95% CI 0.35–0.95); there were no significant associations for lead concentrations in blood and environmental samples. There is a strong isotopic correlation of soils and house dust (r=0.53, 95% CI 0.20–0.75) indicative of a common source(s) for lead in soil and house dust. In contrast, as with the regression analyses, no such association is present for bulk lead concentrations (r=?0.003, 95% CI ?0.37–0.36), the most common approach employed in source investigations. In evaluation of the isotopic results on a case by case basis, the strongest associations were for dust wipes and blood. -- Highlights: • Children with elevated blood lead ?15 µg/dL compared with a group with <10 µg/dL. • High precision lead isotopic ratios in blood, house dust wipes, soil, water, paint. • Associations for isotopic measures of blood and dust, blood and soil, blood and paint. • Regressions gave significance for isotopic measures of blood/dust and dust/soil.

  12. Hemodynamic profile, compensation deficit, and ambulatory blood pressure

    E-Print Network [OSTI]

    Ottaviani, C; Shapiro, D; Goldstein, I B; James, J E; Weiss, R

    2006-01-01T23:59:59.000Z

    1999). Hemodynamic profile of stress-induced anticipationdifferences in hemodynamic profile and blood pressureG. A. (1995). Circadian profile of systemic hemodynamics.

  13. autologous peripheral blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  14. allogeneic peripheral blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  15. adult peripheral blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  16. abnormal blood flow: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  17. aortic blood flow: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  18. allogenic peripheral blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  19. atrial blood flow: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  20. altered blood flow: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  1. artery blood flow: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  2. arterial blood flow: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    blood flow speed and cardiac pulsation using a combined PAM-electrocardiogra- phy (ECG) system, we demonstrated the first in vivo photoa- coustic measurement of the PWV in...

  3. Photoacoustic removal of occlusions from blood vessels

    DOE Patents [OSTI]

    Visuri, Steven R. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Celliers, Peter M. (Berkeley, CA); London, Richard A. (Orinda, CA); Maitland, IV, Duncan J. (Lafayette, CA); Esch, Victor C. (San Francisco, CA)

    2002-01-01T23:59:59.000Z

    Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.

  4. In situ reduction and oxidation of nickel from solid oxide fuel cells in a Titan ETEM

    E-Print Network [OSTI]

    Dunin-Borkowski, Rafal E.

    In situ reduction and oxidation of nickel from solid oxide fuel cells in a Titan ETEM A. Faes1, Denmark antonin.faes@epfl.ch Keywords: In situ ETEM, nickel oxide, reduction, RedOx, SOFC Solid Oxide Fuel. C. Singhal, K. Kendall, High Temperature Solid Oxide Fuel Cell - Fundamentals, Design

  5. Oncolytic measles virus and mesenchymal stromal cells

    E-Print Network [OSTI]

    Jones, Peter JS

    to acute lymphoblastic leukaemia (ALL) ­ a disseminated haematological malignancy. Anti MV antibody titres lymphoblastic leukemia in the presence of humoral immunity. Blood. 2014 Feb 27;123(9):1327-35. doi: 10 AK. Human mesenchymal stromal cells efficiently deliver systemic oncolytic MV to treat acute

  6. 3-amino thioacridone inhibits DNA synthesis and induces DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner

    E-Print Network [OSTI]

    2005-01-01T23:59:59.000Z

    T-lineage acute lymphoblastic leukemia. Blood 91:735-746,damage in T-cell acute lymphoblastic leukemia (T-ALL) in arelapse in T-cell acute lymphoblastic leukemia patients with

  7. Malaria parasite-infected erythrocytes inhibit glucose utilization in uninfected red cells

    E-Print Network [OSTI]

    Sharma, Shobhona

    [2-13 C]glucose and nuclear magnetic resonance, the glucose utilization rate and 2 glycolytic enzyme phospho- fructokinase. This downregulation of the glucose utilization rate in the majority

  8. Computational design of a red fluorophore ligase for site-specific protein labeling in living cells

    E-Print Network [OSTI]

    Drennan, Catherine L.

    Chemical fluorophores offer tremendous size and photophysical advantages over fluorescent proteins but are much more challenging to target to specific cellular proteins. Here, we used Rosetta-based computation to design a ...

  9. Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells

    SciTech Connect (OSTI)

    Guo, Li-Wu [Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States)] [Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States); Wu, Qiangen [Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States)] [Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States); Green, Bridgett; Nolen, Greg [Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States)] [Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States); Shi, Leming [Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States)] [Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States); LoSurdo, Jessica [Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 (United States)] [Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 (United States); Deng, Helen [Arkansas Department of Health, Little Rock, AR 72205 (United States)] [Arkansas Department of Health, Little Rock, AR 72205 (United States); Bauer, Steven [Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 (United States)] [Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 (United States); Fang, Jia-Long, E-mail: jia-long.fang@fda.hhs.gov [Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States)] [Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States); Ning, Baitang, E-mail: baitang.ning@fda.hhs.gov [Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States)] [Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 (United States)

    2012-07-15T23:59:59.000Z

    Humans at all ages are continually exposed to triclosan (TCS), a widely used antimicrobial agent that can be found in many daily hygiene products, such as toothpastes and shampoos; however, the toxicological and biological effects of TCS in the human body after long-term and low-concentration exposure are far from being well understood. In the current study, we investigated the effects of TCS on the differentiation of human mesenchymal stem cells (hMSCs) by measuring the cytotoxicity, morphological changes, lipid accumulation, and the expression of adipocyte differentiation biomarkers during 21-day adipogenesis. Significant cytotoxicity was observed in un-induced hMSCs treated with high-concentration TCS (? 5.0 ?M TCS), but not with low-concentration treatments (? 2.5 ?M TCS). TCS inhibited adipocyte differentiation of hMSCs in a concentration-dependent manner in the 0.156 to 2.5 ?M range as indicated by morphological changes with Oil Red O staining, which is an index of lipid accumulation. The inhibitory effect was confirmed by a decrease in gene expression of specific adipocyte differentiation biomarkers including adipocyte protein 2, lipoprotein lipase, and adiponectin. Our study demonstrates that TCS inhibits adipocyte differentiation of hMSCs under concentrations that are not cytotoxic and in the range observed in human blood. -- Highlights: ? TCS is cytotoxic to un-induced hMSCs at concentrations ? 5.0 ?M. ? TCS at concentrations ? 2.5 ?M is not cytotoxic to induced hMSCs. ? TCS at non-cytotoxic concentrations inhibits lipid formation in induced hMSCs. ? TCS decreases the expression of specific biomarkers of adipocyte differentiation. ? TCS at concentrations observed in human blood inhibits adipogenesis of hMSCs.

  10. Magnetic Field Geometry in "Red" and "Blue" BL Lacs

    E-Print Network [OSTI]

    P. Kharb; D. C. Gabuzda; P. Shastri

    2003-01-06T23:59:59.000Z

    We compare the systematics of the magnetic field geometry in the "red" low-energy peaked BL Lacs (LBLs) and "blue" high-energy peaked BL Lacs (HBLs) using VLBI polarimetric images. The LBLs are primarily "radio--selected" BL Lacs and the HBLs are primarily "X-ray selected". In contrast to the LBLs, which show predominantly transverse jet magnetic fields, the HBLs show predominantly longitudinal fields. Thus, while the SED peaks of core-dominated quasars, LBLs and HBLs form a sequence of increasing frequency, the magnetic field geometry does not follow an analogous sequence. We briefly investigate possible connections between the observed parsec-scale magnetic field structures and circular polarization measurements in the literature on various spatial scales.

  11. Cosmological Constraints from the SDSS Luminous Red Galaxies

    E-Print Network [OSTI]

    M Tegmark; D Eisenstein; M Strauss; D Weinberg; M Blanton; J Frieman; M Fukugita; J Gunn; A Hamilton; G Knapp; R Nichol; J Ostriker; N Padmanabhan; W Percival; D Schlegel; D Schneider; R Scoccimarro; U Seljak; H Seo; M Swanson; A Szalay; M Vogeley; J Yoo; I Zehavi; K Abazajian; S Anderson; J Annis; N Bahcall; B Bassett; A Berlind; J Brinkmann; T Budavari; F Castander; A Connolly; I Csabai; M Doi; D Finkbeiner; B Gillespie; K Glazebrook; G Hennessy; D Hogg; Z Ivezic; B Jain; D Johnston; S Kent; D Lamb; B Lee; H Lin; J Loveday; R Lupton; J Munn; K Pan; C Park; J Peoples; J Pier; A Pope; M Richmond; C Rockosi; R Scranton; R Sheth; A Stebbins; C Stoughton; I Szapudi; D Tucker; D Vanden Berk; B Yanny; D York

    2006-10-30T23:59:59.000Z

    We measure the large-scale real-space power spectrum P(k) using luminous red galaxies (LRGs) in the Sloan Digital Sky Survey (SDSS) and use this measurement to sharpen constraints on cosmological parameters from the Wilkinson Microwave Anisotropy Probe (WMAP). We employ a matrix-based power spectrum estimation method using Pseudo-Karhunen-Loeve eigenmodes, producing uncorrelated minimum-variance measurements in 20 k-bands of both the clustering power and its anisotropy due to redshift-space distortions, with narrow and well-behaved window functions in the range 0.01h/Mpc 0.1h/Mpc and associated nonlinear complications, yet agree well with more aggressive published analyses where nonlinear modeling is crucial.

  12. Continuum and line emission of flares on red dwarf stars

    E-Print Network [OSTI]

    Morchenko, Egor; Livshits, Moisey

    2015-01-01T23:59:59.000Z

    The emission spectrum has been calculated of a homogeneous pure hydrogen layer, which parameters are typical for a flare on a red dwarf. The ionization and excitation states were determined by the solution of steady-state equations taking into account the continuum and all discrete hydrogen levels. We consider the following elementary processes: electron-impact transitions, spontaneous and induced radiative transitions, and ionization by the bremsstrahlung and recombination radiation of the layer itself. The Biberman--Holstein approximation was used to calculate the scattering of line radiation. Asymptotic formulae for the escape probability are obtained for a symmetric line profile taking into account the Stark and Doppler effects. The approximation for the core of the H$-\\alpha$ line by a gaussian curve has been substantiated. The spectral intensity of the continuous spectrum, the intensity of the lines of the Balmer series and the magnitude of the Balmer jump have been calculated. The conditions have been ...

  13. MAGNESIUM ISOTOPE RATIOS IN {omega} CENTAURI RED GIANTS

    SciTech Connect (OSTI)

    Da Costa, G. S.; Norris, John E.; Yong, David [Research School of Astronomy and Astrophysics, Australian National University, Canberra, ACT 0200 (Australia)

    2013-05-20T23:59:59.000Z

    We have used the high-resolution observations obtained at the Anglo-Australian Telescope with Ultra-High Resolution Facility (R {approx} 100,000) and at Gemini-S with b-HROS (R {approx} 150,000) to determine magnesium isotope ratios for seven {omega} Cen red giants that cover a range in iron abundance from [Fe/H] = -1.78 to -0.78 dex, and for two red giants in M4 (NGC 6121). The {omega} Cen stars sample both the ''primordial'' (i.e., O-rich, Na- and Al-poor) and the ''extreme'' (O-depleted, Na- and Al-rich) populations in the cluster. The primordial population stars in both {omega} Cen and M4 show ({sup 25}Mg, {sup 26}Mg)/{sup 24}Mg isotopic ratios that are consistent with those found for the primordial population in other globular clusters with similar [Fe/H] values. The isotopic ratios for the {omega} Cen extreme stars are also consistent with those for extreme population stars in other clusters. The results for the extreme population stars studied indicate that the {sup 26}Mg/{sup 24}Mg ratio is highest at intermediate metallicities ([Fe/H] < -1.4 dex), and for the highest [Al/Fe] values. Further, the relative abundance of {sup 26}Mg in the extreme population stars is notably higher than that of {sup 25}Mg, in contrast to model predictions. The {sup 25}Mg/{sup 24}Mg isotopic ratio in fact does not show any obvious dependence on either [Fe/H] or [Al/Fe] nor, intriguingly, any obvious difference between the primordial and extreme population stars.

  14. PROCESSING TIP . . . BACK TO BASICS: REVISITING BLOOD COLLECTION

    E-Print Network [OSTI]

    Navara, Kristen

    MAY 2009 PROCESSING TIP . . . BACK TO BASICS: REVISITING BLOOD COLLECTION Technological advances it is often a good idea to periodically step back from the small details and revisit the basics. One that approximately 50% of the blood in the carcass will drain out. This represents about 3-4% of total body weight

  15. Radiohalogenated thienylethylamine derivatives for evaluating local cerebral blood flow

    DOE Patents [OSTI]

    Goodman, Mark M. (Knoxville, TN); Knapp, Jr., Furn F. (Oak Ridge, TN)

    1990-01-01T23:59:59.000Z

    Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation or regional blood flow by radioimaging of the brain.

  16. INTRODUCTION Red wood ants play an important role in the ecology of

    E-Print Network [OSTI]

    Thomas, Len

    INTRODUCTION Red wood ants play an important role in the ecology of woodland ecosystems by virtue the ecological impor- tance of red wood ants (Gösswald, 1989) and the conser- vation concern for some species.borkin@clear.net.nz 2 Royal Society for the Protection of Birds, Etive House, Beechwood Park, Inverness, IV2 3BW, UK; e

  17. On Bitcoin and Red Balloons Moshe Babaioff, Microsoft Research, Silicon Valley.

    E-Print Network [OSTI]

    Fiat, Amos

    X On Bitcoin and Red Balloons Moshe Babaioff, Microsoft Research, Silicon Valley. moshe (finding red balloons). We focus on another prominent scenario: Bitcoin, a decentralized electronic currency system. Bitcoin represents a radical new approach to monetary systems. It has been getting a large

  18. Identification of heat source fields from infra-red thermography: Determination of

    E-Print Network [OSTI]

    Identification of heat source fields from infra-red thermography: Determination of `self-heating;Identification of heat source fields from infra-red thermography: Determination of `self-heating' in a dual this goal, and its application to an experimental case of self-heating at a single load level is shown

  19. CHANGES IN QUANTUM YIELD OF PHOTOSYNTHESIS IN THE RED ALGA Porphyridium cruentum

    E-Print Network [OSTI]

    Govindjee

    CHANGES IN QUANTUM YIELD OF PHOTOSYNTHESIS IN THE RED ALGA Porphyridium cruentum CAUSED BY STEPWISE From the Photosynthesis Research Laboratory, Botany Department, University of Illinois, Urbana. Dr of photosynthesis in the red alga Porphyridium cruentum, and the spectral compo- sition of light, changed

  20. REACU V. 1.1 07/02/2011 Red Espaola de Agencias

    E-Print Network [OSTI]

    Fraguela, Basilio B.

    REACU V. 1.1 ­ 07/02/2011 REACU Red Española de Agencias de Calidad Universitaria Evaluación para.1 - 07/02/2011 REACU Red Española de Agencias de Calidad Universitaria INTRODUCCIÓN El Real Decreto 861 criterios y estándares de calidad establecidos por la Comisión Europea mediante la superación de una

  1. Regulation of Thyrotropin mRNA Expression in Red Drum, Sciaenops ocellatus

    E-Print Network [OSTI]

    Jones, Richard Alan

    2012-10-19T23:59:59.000Z

    , circulates with a robust daily rhythm in the sciaenid fish, red drum. Previous research has suggested that the red drum T? cycle is circadian in nature, driven by TSH secretion in the early photophase and inhibited by T? feedback in the early scotophase...

  2. Bright red electroluminescent devices using novel second-ligand-contained europium complexes as emitting layers

    E-Print Network [OSTI]

    Huang, Yanyi

    Bright red electroluminescent devices using novel second-ligand- contained europium complexes) and 1-ethyl-2-(2-pyridyl)benzimidazole (EPBM), two europium complexes, Eu(DBM)3HPBM and Eu(DBM)3EPBM/TPD/Eu(DBM)3EPBM/AlQ/Al emit red light originating from the europium complexes. The EL luminance of Eu(DBM)3

  3. Rheology of human blood plasma: Viscoelastic versus Newtonian behavior

    E-Print Network [OSTI]

    M. Brust; C. Schaefer; L. Pan; M. Garcia; P. E. Arratia; C Wagner

    2013-02-17T23:59:59.000Z

    We investigate the rheological characteristics of human blood plasma in shear and elongational flows. While we can confirm a Newtonian behavior in shear flow within experimental resolution, we find a viscoelastic behavior of blood plasma in the pure extensional flow of a capillary break-up rheometer. The influence of the viscoelasticity of blood plasma on capillary blood flow is tested in a microfluidic device with a contraction-expansion geometry. Differential pressure measurements revealed that the plasma has a pronounced flow resistance compared to that of pure water. Supplementary measurements indicate that the viscoelasticity of the plasma might even lead to viscoelastic instabilities under certain conditions. Our findings show that the viscoelastic properties of plasma should not be ignored in future studies on blood flow.

  4. What is Diabetes? Diabetes is a disease that causes you to have high blood sugar.

    E-Print Network [OSTI]

    What is Diabetes? Diabetes is a disease that causes you to have high blood sugar. DIABETES IS HIGH BLOOD SUGAR We all have sugar in our blood. When you have diabetes you have too much sugar in your blood muscles can then use sugar for fuel. Insulin keeps blood sugar in balance. #12; If you have diabetes

  5. The Effects of Estrogen on Theiler’s Virus Infection of Endothelial Cells

    E-Print Network [OSTI]

    Maher, Steven M.

    2011-01-11T23:59:59.000Z

    the effects of estrogen on Theiler’s virus infection of cells that form the blood-brain barrier (BBB): cerebral vascular endothelial (CVE) cells in vitro. The hypotheses to be tested were that (1) estrogen would have a protective effect on the CVE cells...

  6. Making and Staining a Blood Smear A well-made blood smear is a beauty to behold, and likely to yield interesting and

    E-Print Network [OSTI]

    Schall, Joseph J.

    1 Making and Staining a Blood Smear A well-made blood smear is a beauty to behold, and likely are shown on the website. Dried blood samples for genetic studies should always be made at the same time the microscope with molecular methods. The technique for making and storing dried blood samples is given

  7. The National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Studies (Retrovirus Epidemiology Donor Study and Retrovirus Epidemiology Donor Study-II): Twenty Years of Research to Advance Blood Product Safety and Availability

    E-Print Network [OSTI]

    Kleinman, SH; King, M; Busch, MP; Murphy, EL; Glynn, SA

    2012-01-01T23:59:59.000Z

    BLOOD PRODUCT SAFETY AND AVAILABILITY early primary HIV-1DJ. Increasing blood availability by changing donationBLOOD PRODUCT SAFETY AND AVAILABILITY empathetic concern and

  8. Policy Experimentation and the Search for Institutional Change: The Politics of Red-Green Reform in Germany

    E-Print Network [OSTI]

    Ziegler, J. Nicholas; Leslie, John C.

    2006-01-01T23:59:59.000Z

    the first four years of Germany first Red-Green coalition.OF RED-GREEN REFORM IN GERMANY June 2006 J. Nicholas Zieglercoalition government in Germany between Social Democrats and

  9. An early Miocene age for a high-temperature event in gneisses from Zabargad Island (Red Sea, Egypt): mantle diapirism?

    E-Print Network [OSTI]

    Demouchy, Sylvie

    An early Miocene age for a high-temperature event in gneisses from Zabargad Island (Red Sea, Egypt outcropping on Zabargad Island (Red Sea, Egypt). This island, though of limited size (& 4 km2 ), has an almost

  10. The dependence of Pb distribution in brain cells on the interactions of astroglia and neurons

    E-Print Network [OSTI]

    Bird, Laura C

    2013-02-22T23:59:59.000Z

    Lead (Pb) is a ubiquitous environmental contaminant which has been linked to neurobehavioral deficits, primarily in young children. A current hypothesis for Pb distribution among brain cells is that astroglia, which are interposed between the blood...

  11. Annexin A2 is Required for Endothelial Cell Junctional Response to S1P 

    E-Print Network [OSTI]

    Smith, Rebecca

    2014-01-14T23:59:59.000Z

    Endothelial cell (EC) junctions are critical for angiogenesis, the sprouting and growth of new blood vessels from existing vessels. Sphingosine 1-phosphate (S1P) is a proangiogenic factor that potently stimulates sprouting, fortifies EC junctions...

  12. ARM: Shortwave Array Spectroradiometer-Hemispheric, Near-InfraRed channel, high-sun angles [a0 data is uncalibrated

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Flynn, Connor

    Shortwave Array Spectroradiometer-Hemispheric, Near-InfraRed channel, high-sun angles [a0 data is uncalibrated

  13. ARM: Shortwave Array Spectroradiometer-Hemispheric, Near-InfraRed channel, low-sun angles [a0 data is uncalibrated

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Flynn, Connor

    Shortwave Array Spectroradiometer-Hemispheric, Near-InfraRed channel, low-sun angles [a0 data is uncalibrated

  14. JURO Application Editing Sample Please edit the following passage for style and content. Make edits in red or blue ink.

    E-Print Network [OSTI]

    Arnold, Jonathan

    in red or blue ink. American citizens eat unhealthily all the time. America increasing rely on foreign

  15. The U.S. Department of Energy's Brookhaven National Laboratory P.O. Box 5000, Upton NY 11973 631 344-2345 www.bnl.gov Office of Technology Commercialization

    E-Print Network [OSTI]

    Ohta, Shigemi

    diagnostics and homeland security; and catalysts for producing methanol-powered fuel cells. Sponsored Research Brookhaven Lab for DOE. A few of the licensed products include red-blood- cell labeling kits that are used

  16. Author's personal copy Cellular and physiological mechanisms underlying blood flow regulation in the

    E-Print Network [OSTI]

    Newman, Eric A.

    Author's personal copy Cellular and physiological mechanisms underlying blood flow regulation n f o Article history: Available online 3 May 2012 Keywords: Blood flow Retina Choroid Regulation review the cellular and physiological mechanisms responsible for the regulation of blood flow

  17. Fuel Cells

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fuel Cells Converting chemical energy of hydrogenated fuels into electricity Project Description Invented in 1839, fuels cells powered the Gemini and Apollo space missions, as well...

  18. Origin of the high sensitivity of Chinese red clay soils to drought: significance of the clay characteristics

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Origin of the high sensitivity of Chinese red clay soils to drought: significance of the clay d'Ulm 75230, Paris, France *Corresponding author: Ary.Bruand@univ-orleans.fr Abstract The red clay but the origin of this high sensitivity to drought remains unclear. Several red clay soils were selected

  19. UBC Social Ecological Economic Development Studies (SEEDS) Student Report An Investigation into the Red Listed Material: Pressure Treated Wood

    E-Print Network [OSTI]

    into the Red Listed Material: Pressure Treated Wood (Preservative Infused) and Possible Alternatives Abby Yuen of a project/report". #12;APSC 261 An Investigation into the Red Listed Material: Pressure Treated Wood. Pressure treated wood, a commonly used building material in British Columbia, is a red-listed material

  20. Cell Stem Cell Clinical Progress

    E-Print Network [OSTI]

    Zandstra, Peter W.

    Cell Stem Cell Clinical Progress Rapid Expansion of Human Hematopoietic Stem Cells by Automated of Toronto, Toronto, ON M5G 1L7, Canada 6McEwen Centre for Regenerative Medicine, University Health Network

  1. Spectroscopic Study on the Beryllium Abundances of Red Giant Stars

    E-Print Network [OSTI]

    Takeda, Yoichi

    2014-01-01T23:59:59.000Z

    An extensive spectroscopic study was carried out for the beryllium abundances of 200 red giants (mostly of late G and early K type), which were determined from the near-UV Be II 3131.066 line based on high-dispersion spectra obtained by Subaru/HDS, with an aim of investigating the nature of surface Be contents in these evolved giants; e.g., dependence upon stellar parameters, degree of peculiarity along with its origin and build-up timing. We found that Be is considerably deficient (to widely different degree from star to star) in the photosphere of these evolved giants by ~1-3 dex (or more) compared to the initial abundance. While the resulting Be abundances (A(Be)) appear to weakly depend upon T_eff, log g, [Fe/H], M, age, and v_sin i, this may be attributed to the metallicity dependence of A(Be) coupled with the mutual correlation between these stellar parameters, since such tendencies almost disappear in the metallicity-scaled Be abundance ([Be/Fe]). By comparing the Be abundances (as well as their correl...

  2. The Photophysics of the Carrier of Extended Red Emission

    E-Print Network [OSTI]

    Tracy L. Smith; Adolf N. Witt

    2001-09-26T23:59:59.000Z

    Interstellar dust contains a component which reveals its presence by emitting a broad, unstructured band of light in the 540 to 950 nm wavelength range, referred to as Extended Red Emission (ERE). The presence of interstellar dust and ultraviolet photons are two necessary conditions for ERE to occur. This is the basis for suggestions which attribute ERE to an interstellar dust component capable of photoluminescence. In this study, we have collected all published ERE observations with absolute-calibrated spectra for interstellar environments, where the density of ultraviolet photons can be estimated reliably. In each case, we determined the band-integrated ERE intensity, the wavelength of peak emission in the ERE band, and the efficiency with which absorbed ultraviolet photons are contributing to the ERE. The data show that radiation is not only driving the ERE, as expected for a photoluminescence process, but is modifying the ERE carrier as manifested by a systematic increase in the ERE band's peak wavelength and a general decrease in the photon conversion efficiency with increasing densities of the prevailing exciting radiation. The overall spectral characteristics of the ERE and the observed high quantum efficiency of the ERE process are currently best matched by the recently proposed silicon nanoparticle (SNP) model. Using the experimentally established fact that ionization of semiconductor nanoparticles quenches their photoluminescence, we proceeded to test the SNP model by developing a quantitative model for the excitation and ionization equilibrium of SNPs under interstellar conditions for a wide range of radiation field densities.

  3. YELLOW AND RED SUPERGIANTS IN THE LARGE MAGELLANIC CLOUD

    SciTech Connect (OSTI)

    Neugent, Kathryn F.; Massey, Philip; Skiff, Brian [Lowell Observatory, 1400 W Mars Hill Road, Flagstaff, AZ 86001 (United States); Meynet, Georges, E-mail: kneugent@lowell.edu, E-mail: phil.massey@lowell.edu, E-mail: bas@lowell.edu, E-mail: georges.meynet@unige.ch [Geneva Observatory, Geneva University, CH-1290 Versoix (Switzerland)

    2012-04-20T23:59:59.000Z

    Due to their transitionary nature, yellow supergiants (YSGs) provide a critical challenge for evolutionary modeling. Previous studies within M31 and the Small Magellanic Cloud show that the Geneva evolutionary models do a poor job at predicting the lifetimes of these short-lived stars. Here, we extend this study to the Large Magellanic Cloud (LMC) while also investigating the galaxy's red supergiant (RSG) content. This task is complicated by contamination by Galactic foreground stars that color and magnitude criteria alone cannot weed out. Therefore, we use proper-motions and the LMC's large systemic radial velocity ({approx}278 km s{sup -1}) to separate out these foreground dwarfs. After observing nearly 2000 stars, we identified 317 probable YSGs, 6 possible YSGs, and 505 probable RSGs. Foreground contamination of our YSG sample was {approx}80%, while that of the RSG sample was only 3%. By placing the YSGs on the Hertzsprung-Russell diagram and comparing them against the evolutionary tracks, we find that new Geneva evolutionary models do an exemplary job at predicting both the locations and the lifetimes of these transitory objects.

  4. The Unidentified InfraRed Features after ISO

    E-Print Network [OSTI]

    E. Peeters; L. J. Allamandola; D. M. Hudgins; S. Hony; A. G. G. M. Tielens

    2003-12-06T23:59:59.000Z

    The Infrared Space Observatory (ISO) has provided the first complete mid-IR spectra for a wide range of objects. Almost all of these spectra are dominated by the well-known infrared emission features at 3.3, 6.2, 7.7, and 11.2 $\\mu$m, the so-called Unidentified Infra-Red (UIR) features. Besides the major features, there is an array of minor features and broad plateaux stretching from 3 to 20 $\\mu$m which reveal subtle details of conditions in the emission zones and properties of the carriers. Generally attributed to the vibrational relaxation of UV-pumped Polycyclic Aromatic Hydrocarbon molecules (PAHs) containing some 50--100 C-atoms, these UIR spectra are a treasure trove of information. The ISO spectra have, for the first time, allowed a systematic analysis of the spectral characteristics of the UIR features in a wide variety of environments. The peak positions, profiles, and relative strengths of the major features vary from source to source and spatially within sources. These specific profiles are not unique to certain object types but can occur within each individual source. Here, we review ISO and recent ground-based observations and assess some of their implications.

  5. Modelling of Blood Diseases November 5-9, 2007, Lyon, France

    E-Print Network [OSTI]

    Maume-Deschamps, Véronique

    Workshop Modelling of Blood Diseases November 5-9, 2007, Lyon, France Scientific committee: M (CNRS) Topics: Blood coagulation Hemophilia Leukemia Atherosclerosis Stroke Angiogenesis Plenary

  6. Promoting Blood Donation in Sub-Saharan Africa: Role of Culture and Interventions

    E-Print Network [OSTI]

    Appiah, Bernard

    2013-12-13T23:59:59.000Z

    , both to identify barriers to blood donation and to obtain some recommendations for designing interventions to boost blood donation. Literature searching yielded 3020 publications, including conference abstracts...

  7. Defect Mass in Gravitational Field and Red Shift of Atomic and Nuclear Radiation Spectra

    E-Print Network [OSTI]

    Kh. M. Beshtoev

    2000-04-19T23:59:59.000Z

    It is shown, that radiation spectrum of atoms (or nuclei) in the gravitational field has a red shift since the effective mass of radiating electrons (or nucleons) changes in this field. This red shift is equal to the red shift of radiation spectrum in the gravitational field measured in existence experiments. The same shift must arise when the photon (or $ \\gamma $ quantum) is passing through the gravitational field if it participates in gravitational interactions (photon has no rest mass). The absence of the double effect in the experiments, probably, means that photons (or $ \\gamma $ quanta) are passing through the gravitational field without interactions.

  8. abnormal portal blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Effect of the site of infusion of para-aminohippuric acid (PAH) on portal blood flow Physics Websites Summary:...

  9. Hemorrhagic stress effects on blood in irradiated rats

    E-Print Network [OSTI]

    Elissalde, Marcel Howell

    1966-01-01T23:59:59.000Z

    conditions the leukocyte, platelet and reticulo- cyte counts in the circulating blood of the human are back to norsml within two weeks following hemorrhage (26). Because of the gradual readjustment of circulatory volume and the general vasoconstriction...

  10. axial flow blood: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the case of an aneurism. Delestre, Olivier 2012-01-01 193 Blood-Flow Modelling Along and Trough a Braided Multi-Layer Metallic Stent CERN Preprints Summary: In this work we study...

  11. airway blood flow: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    lungs. Paolo Pelosi; Patricia Rm Rocco 2007-01-01 146 Blood-Flow Modelling Along and Trough a Braided Multi-Layer Metallic Stent CERN Preprints Summary: In this work we study...

  12. adenocarcinoma blood concentrations: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Walter J. Rogan 2005-01-01 20 Vitamin E concentration in blood plasma of goats fed palm oil leaves Computer Technologies and Information Sciences Websites Summary: pens and given...

  13. applying blood fix: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    o Reinfuse the patient's blood slowly, no faster than 1mL per second, by pressing the plunger back Kay, Mark A. 249 Lecture 4: Fixed Points September 19, 2007 Computer...

  14. abnormal blood pressure: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to flow through the artery, the measurement of which determines the systolic pressure. Pulse rate is also sensed at this time. The measurement taken when the blood flow is no...

  15. Modeling the growth and dissolution of clots in flowing blood 

    E-Print Network [OSTI]

    Mohan, Anand

    2006-10-30T23:59:59.000Z

    Multiple interacting mechanisms control the formation and dissolution of clots to maintain blood in a state of delicate balance. In addition to a myriad of biochemical reactions, rheological factors also play a crucial role in modulating...

  16. SWIRE: The SIRTF Wide-area InfraRed Extragalactic Survey

    E-Print Network [OSTI]

    Carol J. Lonsdale; Harding E. Smith; Michael Rowan-Robinson; Jason Surace; David Shupe; Cong Xu; Seb Oliver; Deborah Padgett; Fan Fang; Alberto Franceschini; Nick Gautier; Matt Griffin; Frank Masci; Glenn Morrison; JoAnn O'Linger; Ismael Perez-Fournon; Marguerite Pierre; Richard Puetter; Gordon Stacey

    2003-05-20T23:59:59.000Z

    The SIRTF Wide-area InfraRed Extragalactic survey (SWIRE), the largest SIRTF Legacy program, is a wide-area, imaging survey to trace the evolution of dusty, star-forming galaxies, evolved stellar populations, and AGN as a function of environment, from redshifts z~3 to the current epoch. SWIRE will survey 7 high-latitude fields, totaling 60 - 65 sq. deg. in all 7 SIRTF bands: IRAC 3.6, 4.5, 5.6, 8 microns and MIPS 24, 70, 160 microns. The Legacy Extragalactic Catalog may contain in excess of 2 million IR-selected galaxies, dominated by (1) ~150,000 luminous infrared galaxies (LIRGs: L{FIR}>10^11 L_sun), ~7000 of these with z>2; (2) 1 million early-type galaxies, ~10,000 with z>2; and (3) \\~20,000 classical AGN, plus significantly more dust-obscured QSO/AGN among the LIRGs. SWIRE will provide an unprecedented view of the evolution of galaxies, structure, and AGN. The key scientific goals of SWIRE are: (1) to determine the evolution of actively star-forming and passively evolving galaxies in order to understand the history of galaxy formation in the context of cosmic structure formation; (2) to determine the evolution of the spatial distribution and clustering of evolved galaxies, starbursts and AGN in the key redshift range, 0.5cells that we can resolve the star formation history as a function of epoch and environment The large volume is also optimised for finding rare objects.

  17. Radial Velocity Curves of Ellipsoidal Red Giant Binaries in the Large Magellanic Cloud

    E-Print Network [OSTI]

    Nie, J D

    2015-01-01T23:59:59.000Z

    Ellipsoidal red giant binaries are close binary systems where an unseen, relatively close companion distorts the red giant, leading to light variations as the red giant moves around its orbit. These binaries are likely to be the immediate evolutionary precursors of close binary planetary nebula and post-asymptotic giant branch and post-red giant branch stars. Due to the MACHO and OGLE photometric monitoring projects, the light variability nature of these ellipsoidal variables has been well studied. However, due to the lack of radial velocity curves, the nature of their masses, separations, and other orbital details has so far remained largely unknown. In order to improve this situation, we have carried out spectral monitoring observations of a large sample of 80 ellipsoidal variables in the Large Magellanic Cloud and we have derived radial velocity curves. At least 12 radial velocity points with good quality were obtained for most of the ellipsoidal variables. The radial velocity data are provided with this p...

  18. The Ratchet and the Red Queen: the maintenance of sex in parasites

    E-Print Network [OSTI]

    Howard, Stephen

    The Ratchet and the Red Queen: the maintenance of sex in parasites R. S. HOWARD* & C. M. LIVELY for the stochastic accumulation of mutations in the finite parasite populations (Muller's Ratchet). We found that

  19. Microsoft Word - CX-Franklin-BadgerCanyonGrandview-RedMtnsDisconnectSw...

    Broader source: Energy.gov (indexed) [DOE]

    8, 2012 REPLY TO ATTN OF: KEPR-4 SUBJECT: Environmental Clearance Memorandum Richard Heredia Project Manager - TEP-TPP-1 Proposed Action: Franklin-Badger Canyon and Grandview-Red...

  20. Characteristics of warm season precipitating storms in the Arkansas–Red River basin

    E-Print Network [OSTI]

    Tucker, Donna F.; Li, Xingong

    2009-07-16T23:59:59.000Z

    [1] Analysis of a multisensor precipitation product enables us to extract the precipitation from individual storms in the Arkansas–Red River drainage basin over a period of 11 years. We examine the year-to-year and ...

  1. redMaPPer IV: Photometric Membership Identification of Cluster Galaxies with 1% Precision

    E-Print Network [OSTI]

    Rozo, Eduardo; Becker, Matthew; Reddick, Rachel M; Wechsler, Risa H

    2014-01-01T23:59:59.000Z

    In order to study the galaxy population of galaxy clusters with photometric data one must be able to accurately discriminate between cluster members and non-members. The redMaPPer cluster finding algorithm treats this problem probabilistically. Here, we utilize SDSS and GAMA spectroscopic membership rates to validate the redMaPPer membership probability estimates for clusters with $z\\in[0.1,0.3]$. We find small - but correctable - biases, sourced by three different systematics. The first two were expected a priori, namely blue cluster galaxies and correlated structure along the line of sight. The third systematic is new: the redMaPPer template fitting exhibits a non-trivial dependence on photometric noise, which biases the original redMaPPer probabilities when utilizing noisy data. After correcting for these effects, we find exquisite agreement ($\\approx 1\\%$) between the photometric probability estimates and the spectroscopic membership rates, demonstrating that we can robustly recover cluster membership est...

  2. Interaction of temperature, dissolved oxygen and feed energy on ecophysiological performance of juvenile red drum 

    E-Print Network [OSTI]

    Fontaine, Lance Pierre

    2008-10-10T23:59:59.000Z

    The red drum (Sciaenops ocellatus) is important for recreational fishing and aquacultural production in Texas' coastal waters and elsewhere in the nearshore Gulf of Mexico and in subtemperate to subtropical areas of the ...

  3. Study of Midgut Bacteria in the Red Imported Fire Ant, Solenopsis invicta Büren (Hymenoptera: Formicidae)

    E-Print Network [OSTI]

    Medina, Freder

    2011-08-08T23:59:59.000Z

    that manipulate insect reproduction, development and even provide defense against parasitoids and pathogens. In this study we investigated the presence of bacteria inside the Red Imported Fire Ant midgut using molecular tools and transmission electron microscopy...

  4. Red River Stream Improvement Final Design Nez Perce National Forest.

    SciTech Connect (OSTI)

    Watershed Consulting, LLC

    2007-03-15T23:59:59.000Z

    This report details the final stream improvement design along the reach of Red River between the bridge below Dawson Creek, upstream for approximately 2 miles, Idaho County, Idaho. Geomorphic mapping, hydrologic profiles and cross-sections were presented along with existing fish habitat maps in the conceptual design report. This information is used to develop a stream improvement design intended to improve aquatic habitat and restore riparian health in the reach. The area was placer mined using large bucket dredges between 1938 and 1957. This activity removed most of the riparian vegetation in the stream corridor and obliterated the channel bed and banks. The reach was also cut-off from most valley margin tributaries. In the 50 years since large-scale dredging ceased, the channel has been re-established and parts of the riparian zone have grown in. However, the recruitment of large woody debris to the stream has been extremely low and overhead cover is poor. Pool habitat makes up more than 37% of the reach, and habitat diversity is much better than the project reach on Crooked River. There is little large woody debris in the stream to provide cover for spawning and juvenile rearing, because the majority of the woody debris does not span a significant part of the channel, but is mainly on the side slopes of the stream. Most of the riparian zone has very little soil or subsoil left after the mining and so now consists primarily of unconsolidated cobble tailings or heavily compacted gravel tailings. Knapweed and lodgepole pine are the most successful colonizers of these post mining landforms. Tributary fans which add complexity to many other streams in the region, have been isolated from the main reach due to placer mining and road building.

  5. RED TERICA, EVOLUCIN TERICA Y HOLONES EN ARQUEOLOGA Autor: Magster. Mara Virginia Ferro

    E-Print Network [OSTI]

    Boyer, Edmond

    1 RED TE�RICA, EVOLUCI�N TE�RICA Y HOLONES EN ARQUEOLOGÍA Autor: Magster. María Virginia Ferro desde conceptos de evolución teórica, redes teóricas y holones en el desarrollo de la arqueología. Primera Parte: Evolución y red teórica; holones desde metateoría. Siguiendo a Balzer, Moulines y Sneed

  6. Evaluation of glufosinate for the control of red rice (Oryza sativa) in commercial rice (Oryza sativa) 

    E-Print Network [OSTI]

    Hessler, Melanie Dawn

    1999-01-01T23:59:59.000Z

    EVALUATION OF GLUFOSINATK FOR THE CONTROL OF RED RICE (Orna sativa) IN COMMERCIAL RICK (Oryta sativa) A Thesis by MELANIE DAWN HESSLER Submitted to the OIIice of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1999 Major Subject; Agronomy EVALUATION OF GLUFOSINATE FOR THE CONTROL OF RED RICK (Oryza siva) IN COMMERCIAL RICK (Orna su&a) A Thesis by MELANIE DAWN HESSLER Submitted to the Ofiice of Graduate...

  7. A Preliminary Microsatellite Linkage Map of the Red Drum (Sciaenops ocellatus)

    E-Print Network [OSTI]

    Hollenbeck, Christopher

    2011-01-11T23:59:59.000Z

    A PRELIMINARY MICROSATELLITE LINKAGE MAP OF THE RED DRUM (SCIAENOPS OCELLATUS) Major: Biology April 2009 Submitted to the Office of Undergraduate Research Texas A&M University in partial fulfillment of the requirements... for the designation as UNDERGRADUATE RESEARCH SCHOLAR A Senior Scholars Thesis by CHRISTOPHER M. HOLLENBECK A PRELIMINARY MICROSATELLITE LINKAGE MAP OF THE RED DRUM (SCIAENOPS OCELLATUS) Approved by: Research Advisor: John R. Gold Associate...

  8. The effects of selected sound pressure levels on the color discrimination of red, yellow, and green

    E-Print Network [OSTI]

    Stone, Raymond Bruce

    1972-01-01T23:59:59.000Z

    THE EFFECTS OF SELECTED SOUND PRESSURE LEVELS ON THE COLOR DISCRIMINATION OF RED, YELLOW AND GREEN A Thesis by RAYMOND BRUCE STONE Submitted to the Graduate College of Texas AB, M University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE August, 1972 Major Subject: Industrial Safety THE EFFECTS OF SELECTED SOUND PRESSURE LEVELS ON THE COLOR DISCRIMINATION OF RED, YELLOW AND GREEN A Thesis by RAYMOND BRUCE STONE Approved as to style and content by: C...

  9. Identification and evaluation of volatile compounds associated with vacuum and modified atmosphere packaged fresh red meats

    E-Print Network [OSTI]

    Jackson, Timothy Court

    1989-01-01T23:59:59.000Z

    IDENTIFICATION AND EVALUATION OF VOLATILE COMPOUNDS ASSOCIATED WITH VACUUM AND MODIFIED ATMOSPHERE PACKAGED FRESH RED MEATS A Thesis by TIMOTHY COURT JACKSON Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE August 1989 Major Subject: Food Science and Technology IDENTIFICATION AND EVALUATION OF VOLATILE COMPOUNDS ASSOCIATED WITH VACUUM AND MODIFIED ATMOSPHERE PACKAGED FRESH RED MEATS A...

  10. Blueshift Without Blueshift: Red Hole Gamma-Ray Burst Models Explain the Peak energy Distribution

    E-Print Network [OSTI]

    James S. Graber

    1999-12-15T23:59:59.000Z

    Gamma-ray bursts are still a puzzle. In particular, the central engine, the total energy and the very narrow distribution of peak energies challenge model builders. We consider here an extreme model of gamma-ray bursts based on highly red- and blue-shifted positron annihilation radiation. The burst emerges from inside the red hole created by the complete gravitational collapse of the GRB progenitor.

  11. Blood-flow magnetic resonance imaging of the retina Yingxia Li,a,1

    E-Print Network [OSTI]

    Duong, Timothy Q.

    Blood-flow magnetic resonance imaging of the retina Yingxia Li,a,1 Haiying Cheng,a,1 and Timothy Q 1 November 2007 This study describes a novel MRI application to image basal blood flow, physiologically induced blood-flow changes, and the effects of isoflurane concentration on blood flow

  12. Predictive Simulation of Bidirectional Glenn Shunt Using a Hybrid Blood Vessel Model

    E-Print Network [OSTI]

    Leow, Wee Kheng

    Predictive Simulation of Bidirectional Glenn Shunt Using a Hybrid Blood Vessel Model Hao Li1 to model the deformation of blood vessels. The hybrid blood vessel model consists of a reference Cosserat rod and a surface mesh. The reference Cosserat rod models the blood vessel's global bending

  13. Biomedical Applications for Correlation Di usion 5.1 Blood Flow Monitoring

    E-Print Network [OSTI]

    Chapter 5 Biomedical Applications for Correlation Di usion 5.1 Blood Flow Monitoring Near-infraredspectroscopy(NIRS)has long beenused to non-invasivelymeasurepulse rate 8, 9, 10] and blood oxygenation 5, 6, 7, 10] and recently to measure blood ow 19, 121]. The advantage of NIRS over laser Doppler blood owmetry (LDBF

  14. Blood Glucose Level Prediction using Physiological Models and Support Vector Regression

    E-Print Network [OSTI]

    Bunescu, Razvan C.

    Blood Glucose Level Prediction using Physiological Models and Support Vector Regression Razvan continually monitor their blood glucose levels and adjust insulin doses, striving to keep blood glucose levels as close to normal as possible. Blood glucose levels that deviate from the normal range can lead to serious

  15. The Centre for Blood Research Athan Kuliopulos, MD, PhD

    E-Print Network [OSTI]

    Strynadka, Natalie

    The Centre for Blood Research Athan Kuliopulos, MD, PhD Director, Hemostasis & Thrombosis coating blood vessel walls rupture and expose collagen, platelets spring into action to form a blood clot, according to the researchers. Compared to other diseases, blood clotting has been very well understood

  16. RESEARCH ARTICLE Blood longitudinal (T1) and transverse (T2) relaxation time

    E-Print Network [OSTI]

    Duong, Timothy Q.

    RESEARCH ARTICLE Blood longitudinal (T1) and transverse (T2) relaxation time constants at 11 The goal of the study was to determine blood T1 and T2 values as functions of oxygen saturation (Y), tem on physiological measurements, including cerebral blood flow (CBF), blood volume (CBV) and oxygenation

  17. A Mathematical Model for Blood Clotting Sumanth Swaminathan David A. Edwards

    E-Print Network [OSTI]

    Edwards, David A.

    A Mathematical Model for Blood Clotting Sumanth Swaminathan David A. Edwards Department that they play in a given system. Vascular blood flow is characterized by convective, diffusive, and reactive processes. Specifically, blood clot formation involves platelet convection within the blood stream

  18. Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    sickle cell anemia (SS) patients. Results: Muscle microvascular oxygenation was reduced in SS patients;4 Introduction Patients with sickle cell disease (SCD) are characterized by anemia and altered blood rheology1 Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced

  19. SUPERNOVA 2008bk AND ITS RED SUPERGIANT PROGENITOR

    SciTech Connect (OSTI)

    Van Dyk, Schuyler D.; Elias-Rosa, Nancy [Spitzer Science Center/Caltech, Mailcode 220-6, Pasadena, CA 91125 (United States); Davidge, Tim J., E-mail: vandyk@ipac.caltech.edu, E-mail: tim.davidge@nrc.ca [Herzberg Institute of Astrophysics, National Research Council of Canada, Victoria, B.C., V9E 2E7 (Canada); and others

    2012-01-15T23:59:59.000Z

    We have obtained limited photometric and spectroscopic data for supernova (SN) 2008bk in NGC 7793, primarily at {approx}> 150 days after explosion. We find that it is a Type II-Plateau (II-P) SN that most closely resembles the low-luminosity SN 1999br in NGC 4900. Given the overall similarity between the observed light curves and colors of SNe 2008bk and 1999br, we infer that the total visual extinction to SN 2008bk (A{sub V} = 0.065 mag) must be almost entirely due to the Galactic foreground, similar to what has been assumed for SN 1999br. We confirm the identification of the putative red supergiant (RSG) progenitor star of the SN in high-quality g'r'i' images we had obtained in 2007 at the Gemini-South 8 m telescope. Little ambiguity exists in this progenitor identification, qualifying it as the best example to date, next to the identification of the star Sk -69 Degree-Sign 202 as the progenitor of SN 1987A. From a combination of photometry of the Gemini images with that of archival, pre-SN, Very Large Telescope JHK{sub s} images, we derive an accurate observed spectral energy distribution (SED) for the progenitor. We find from nebular strong-intensity emission-line indices for several H II regions near the SN that the metallicity in the environment is likely subsolar (Z Almost-Equal-To 0.6 Z{sub Sun }). The observed SED of the star agrees quite well with synthetic SEDs obtained from model RSG atmospheres with effective temperature T{sub eff} = 3600 {+-} 50 K. We find, therefore, that the star had a bolometric luminosity with respect to the Sun of log (L{sub bol}/L{sub Sun} ) = 4.57 {+-} 0.06 and radius R{sub *} = 496 {+-} 34 R{sub Sun} at {approx}6 months prior to explosion. Comparing the progenitor's properties with theoretical massive-star evolutionary models, we conclude that the RSG progenitor had an initial mass in the range of 8-8.5 M{sub Sun }. This mass is consistent with, albeit at the low end of, the inferred range of initial masses for SN II-P progenitors. It is also consistent with the estimated upper limit on the initial mass of the progenitor of SN 1999br, and it agrees with the low initial masses found for the RSG progenitors of other low-luminosity SNe II-P.

  20. Peridural anesthesia and the distribution of blood in supine humans

    SciTech Connect (OSTI)

    Arndt, J.O.; Hoeck, A.S.; Stanton-Hicks, M.; Stuehmeier, K.D.

    1985-12-01T23:59:59.000Z

    To determine the effects of vasomotor tone on intrathoracic and splanchnic blood volume, the distribution of radioactively (/sup 99m/Tc) labeled erythrocytes was recorded by whole body scintigraphy before and during peridural anesthesia (PDA) in eight supine men. The radioactivity was recorded with a gamma camera and its distribution determined in the thorax, abdomen, and limbs. Arterial and central venous pressure, heart rate, and calf volume and flow also were measured. During PDA with a sensory block up to T4/5, radioactivity increased only in the denervated legs, whereas it decreased in all other regions, i.e., in the thorax, the innervated upper limbs, and in the splanchnic vasculature. However, in two of the subjects, after an initial decrease, splanchnic blood content increased while intrathoracic blood volume decreased further. The effects of PDA on thoracic and splanchnic filling could be duplicated by the sequestration of about 500-600 ml of blood in both legs. In supine humans high peridural anesthesia evokes the same decrease in intrathoracic blood volume as orthostasis. Potential circulatory collapse may ensue when the vasoconstrictor response fails in the splanchnic circulation.